-- dump date 20140620_083116 -- class Genbank::misc_feature -- table misc_feature_note -- id note 511691000001 oriT 511691000002 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 511691000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511691000004 Walker A motif; other site 511691000005 ATP binding site [chemical binding]; other site 511691000006 Walker B motif; other site 511691000007 arginine finger; other site 511691000008 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 511691000009 DnaA box-binding interface [nucleotide binding]; other site 511691000010 DNA polymerase III subunit beta; Validated; Region: PRK05643 511691000011 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 511691000012 putative DNA binding surface [nucleotide binding]; other site 511691000013 dimer interface [polypeptide binding]; other site 511691000014 beta-clamp/clamp loader binding surface; other site 511691000015 beta-clamp/translesion DNA polymerase binding surface; other site 511691000016 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 511691000017 GTP-binding protein YchF; Reviewed; Region: PRK09601 511691000018 YchF GTPase; Region: YchF; cd01900 511691000019 G1 box; other site 511691000020 GTP/Mg2+ binding site [chemical binding]; other site 511691000021 Switch I region; other site 511691000022 G2 box; other site 511691000023 Switch II region; other site 511691000024 G3 box; other site 511691000025 G4 box; other site 511691000026 G5 box; other site 511691000027 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 511691000028 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 511691000029 putative active site [active] 511691000030 catalytic residue [active] 511691000031 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 511691000032 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 511691000033 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 511691000034 ATP binding site [chemical binding]; other site 511691000035 putative Mg++ binding site [ion binding]; other site 511691000036 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511691000037 nucleotide binding region [chemical binding]; other site 511691000038 ATP-binding site [chemical binding]; other site 511691000039 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 511691000040 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 511691000041 RNA binding surface [nucleotide binding]; other site 511691000042 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 511691000043 Septum formation initiator; Region: DivIC; pfam04977 511691000044 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 511691000045 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 511691000046 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 511691000047 Ligand Binding Site [chemical binding]; other site 511691000048 TilS substrate C-terminal domain; Region: TilS_C; smart00977 511691000049 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511691000050 active site 511691000051 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 511691000052 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511691000053 Walker A motif; other site 511691000054 ATP binding site [chemical binding]; other site 511691000055 Walker B motif; other site 511691000056 arginine finger; other site 511691000057 Peptidase family M41; Region: Peptidase_M41; pfam01434 511691000058 amino acid transporter; Region: 2A0306; TIGR00909 511691000059 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 511691000060 rod shape-determining protein MreC; Provisional; Region: PRK13922 511691000061 rod shape-determining protein MreC; Region: MreC; pfam04085 511691000062 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 511691000063 Surface antigen [General function prediction only]; Region: COG3942 511691000064 CHAP domain; Region: CHAP; pfam05257 511691000065 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269 511691000066 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 511691000067 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511691000068 active site 511691000069 aromatic amino acid aminotransferase; Validated; Region: PRK07309 511691000070 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 511691000071 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511691000072 homodimer interface [polypeptide binding]; other site 511691000073 catalytic residue [active] 511691000074 Recombination protein O N terminal; Region: RecO_N; pfam11967 511691000075 DNA repair protein RecO; Region: reco; TIGR00613 511691000076 Recombination protein O C terminal; Region: RecO_C; pfam02565 511691000077 putative phosphate acyltransferase; Provisional; Region: PRK05331 511691000078 acyl carrier protein; Provisional; Region: PRK12449 511691000079 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511691000080 Walker A/P-loop; other site 511691000081 ATP binding site [chemical binding]; other site 511691000082 ABC transporter; Region: ABC_tran; pfam00005 511691000083 Q-loop/lid; other site 511691000084 ABC transporter signature motif; other site 511691000085 Walker B; other site 511691000086 D-loop; other site 511691000087 H-loop/switch region; other site 511691000088 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 511691000089 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 511691000090 ATP binding site [chemical binding]; other site 511691000091 active site 511691000092 substrate binding site [chemical binding]; other site 511691000093 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 511691000094 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 511691000095 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 511691000096 dimerization interface [polypeptide binding]; other site 511691000097 ATP binding site [chemical binding]; other site 511691000098 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 511691000099 dimerization interface [polypeptide binding]; other site 511691000100 ATP binding site [chemical binding]; other site 511691000101 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 511691000102 putative active site [active] 511691000103 catalytic triad [active] 511691000104 A new structural DNA glycosylase; Region: AlkD_like; cl11434 511691000105 HEAT repeats; Region: HEAT_2; pfam13646 511691000106 active site 511691000107 amidophosphoribosyltransferase; Provisional; Region: PRK07272 511691000108 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 511691000109 active site 511691000110 tetramer interface [polypeptide binding]; other site 511691000111 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511691000112 active site 511691000113 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 511691000114 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 511691000115 dimerization interface [polypeptide binding]; other site 511691000116 putative ATP binding site [chemical binding]; other site 511691000117 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 511691000118 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 511691000119 active site 511691000120 substrate binding site [chemical binding]; other site 511691000121 cosubstrate binding site; other site 511691000122 catalytic site [active] 511691000123 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 511691000124 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 511691000125 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 511691000126 purine monophosphate binding site [chemical binding]; other site 511691000127 dimer interface [polypeptide binding]; other site 511691000128 putative catalytic residues [active] 511691000129 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 511691000130 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 511691000131 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 511691000132 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 511691000133 hypothetical protein; Provisional; Region: PHA03335 511691000134 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 511691000135 Abi-like protein; Region: Abi_2; pfam07751 511691000136 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 511691000137 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 511691000138 Mg2+ binding site [ion binding]; other site 511691000139 G-X-G motif; other site 511691000140 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 511691000141 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511691000142 ATP binding site [chemical binding]; other site 511691000143 Mg2+ binding site [ion binding]; other site 511691000144 G-X-G motif; other site 511691000145 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 511691000146 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 511691000147 active site 511691000148 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 511691000149 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 511691000150 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 511691000151 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 511691000152 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 511691000153 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 511691000154 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 511691000155 ATP-grasp domain; Region: ATP-grasp; pfam02222 511691000156 P-loop containing region of AAA domain; Region: AAA_29; cl17516 511691000157 AAA domain; Region: AAA_13; pfam13166 511691000158 adenylosuccinate lyase; Provisional; Region: PRK07492 511691000159 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 511691000160 tetramer interface [polypeptide binding]; other site 511691000161 active site 511691000162 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 511691000163 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 511691000164 active site 511691000165 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 511691000166 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511691000167 non-specific DNA binding site [nucleotide binding]; other site 511691000168 salt bridge; other site 511691000169 sequence-specific DNA binding site [nucleotide binding]; other site 511691000170 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 511691000171 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 511691000172 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511691000173 Walker A motif; other site 511691000174 ATP binding site [chemical binding]; other site 511691000175 Walker B motif; other site 511691000176 arginine finger; other site 511691000177 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 511691000178 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 511691000179 Low molecular weight phosphatase family; Region: LMWPc; cd00115 511691000180 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 511691000181 Acyltransferase family; Region: Acyl_transf_3; pfam01757 511691000182 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 511691000183 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 511691000184 catalytic triad [active] 511691000185 catalytic triad [active] 511691000186 oxyanion hole [active] 511691000187 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 511691000188 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 511691000189 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511691000190 catalytic residue [active] 511691000191 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 511691000192 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 511691000193 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 511691000194 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 511691000195 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 511691000196 catalytic core [active] 511691000197 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 511691000198 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 511691000199 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 511691000200 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 511691000201 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 511691000202 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 511691000203 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 511691000204 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 511691000205 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 511691000206 substrate binding [chemical binding]; other site 511691000207 active site 511691000208 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 511691000209 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 511691000210 Laminin G domain; Region: Laminin_G_2; pfam02210 511691000211 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 511691000212 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 511691000213 substrate binding [chemical binding]; other site 511691000214 active site 511691000215 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 511691000216 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 511691000217 GrpE; Region: GrpE; pfam01025 511691000218 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 511691000219 dimer interface [polypeptide binding]; other site 511691000220 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 511691000221 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 511691000222 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 511691000223 nucleotide binding site [chemical binding]; other site 511691000224 NEF interaction site [polypeptide binding]; other site 511691000225 SBD interface [polypeptide binding]; other site 511691000226 chaperone protein DnaJ; Provisional; Region: PRK14276 511691000227 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 511691000228 HSP70 interaction site [polypeptide binding]; other site 511691000229 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 511691000230 substrate binding site [polypeptide binding]; other site 511691000231 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 511691000232 Zn binding sites [ion binding]; other site 511691000233 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 511691000234 dimer interface [polypeptide binding]; other site 511691000235 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 511691000236 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 511691000237 dimerization interface 3.5A [polypeptide binding]; other site 511691000238 active site 511691000239 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 511691000240 dimer interface [polypeptide binding]; other site 511691000241 substrate binding site [chemical binding]; other site 511691000242 ATP binding site [chemical binding]; other site 511691000243 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 511691000244 hypothetical protein; Provisional; Region: PRK13690 511691000245 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 511691000246 Mechanosensitive ion channel; Region: MS_channel; pfam00924 511691000247 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 511691000248 trigger factor; Provisional; Region: tig; PRK01490 511691000249 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 511691000250 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 511691000251 Methyltransferase domain; Region: Methyltransf_31; pfam13847 511691000252 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511691000253 S-adenosylmethionine binding site [chemical binding]; other site 511691000254 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 511691000255 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 511691000256 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 511691000257 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 511691000258 S-ribosylhomocysteinase; Provisional; Region: PRK02260 511691000259 Predicted transcriptional regulator [Transcription]; Region: COG1959 511691000260 Transcriptional regulator; Region: Rrf2; pfam02082 511691000261 Transcriptional regulator; Region: Rrf2; cl17282 511691000262 Nitrate/nitrite transporter [Inorganic ion transport and metabolism]; Region: NarK; COG2223 511691000263 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511691000264 Plasmid replication protein; Region: Rep_2; pfam01719 511691000265 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 511691000266 Int/Topo IB signature motif; other site 511691000267 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 511691000268 CTP synthetase; Validated; Region: pyrG; PRK05380 511691000269 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 511691000270 Catalytic site [active] 511691000271 active site 511691000272 UTP binding site [chemical binding]; other site 511691000273 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 511691000274 active site 511691000275 putative oxyanion hole; other site 511691000276 catalytic triad [active] 511691000277 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 511691000278 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 511691000279 intersubunit interface [polypeptide binding]; other site 511691000280 active site 511691000281 zinc binding site [ion binding]; other site 511691000282 Na+ binding site [ion binding]; other site 511691000283 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 511691000284 active site 511691000285 phosphorylation site [posttranslational modification] 511691000286 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 511691000287 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 511691000288 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 511691000289 active pocket/dimerization site; other site 511691000290 active site 511691000291 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 511691000292 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 511691000293 putative active site [active] 511691000294 putative catalytic site [active] 511691000295 Transcriptional regulators [Transcription]; Region: PurR; COG1609 511691000296 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 511691000297 DNA binding site [nucleotide binding] 511691000298 domain linker motif; other site 511691000299 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 511691000300 dimerization interface [polypeptide binding]; other site 511691000301 ligand binding site [chemical binding]; other site 511691000302 sodium binding site [ion binding]; other site 511691000303 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 511691000304 frameshift of SMU.107 511691000305 frameshift of SMU.108 511691000306 H+ Antiporter protein; Region: 2A0121; TIGR00900 511691000307 Helix-turn-helix domain; Region: HTH_19; pfam12844 511691000308 sequence-specific DNA binding site [nucleotide binding]; other site 511691000309 salt bridge; other site 511691000310 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 511691000311 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 511691000312 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 511691000313 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 511691000314 putative active site [active] 511691000315 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 511691000316 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 511691000317 putative substrate binding site [chemical binding]; other site 511691000318 putative ATP binding site [chemical binding]; other site 511691000319 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 511691000320 active site 511691000321 P-loop; other site 511691000322 phosphorylation site [posttranslational modification] 511691000323 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 511691000324 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 511691000325 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 511691000326 active site 511691000327 phosphorylation site [posttranslational modification] 511691000328 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK04161 511691000329 S-formylglutathione hydrolase; Region: PLN02442 511691000330 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 511691000331 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 511691000332 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 511691000333 substrate binding site [chemical binding]; other site 511691000334 catalytic Zn binding site [ion binding]; other site 511691000335 NAD binding site [chemical binding]; other site 511691000336 structural Zn binding site [ion binding]; other site 511691000337 dimer interface [polypeptide binding]; other site 511691000338 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 511691000339 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 511691000340 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 511691000341 DNA polymerase III PolC; Validated; Region: polC; PRK00448 511691000342 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 511691000343 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 511691000344 generic binding surface II; other site 511691000345 generic binding surface I; other site 511691000346 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 511691000347 active site 511691000348 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 511691000349 active site 511691000350 catalytic site [active] 511691000351 substrate binding site [chemical binding]; other site 511691000352 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 511691000353 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 511691000354 MarR family; Region: MarR; pfam01047 511691000355 Predicted flavoprotein [General function prediction only]; Region: COG0431 511691000356 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 511691000357 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 511691000358 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 511691000359 tetramer interface [polypeptide binding]; other site 511691000360 TPP-binding site [chemical binding]; other site 511691000361 heterodimer interface [polypeptide binding]; other site 511691000362 phosphorylation loop region [posttranslational modification] 511691000363 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 511691000364 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 511691000365 alpha subunit interface [polypeptide binding]; other site 511691000366 TPP binding site [chemical binding]; other site 511691000367 heterodimer interface [polypeptide binding]; other site 511691000368 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 511691000369 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 511691000370 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 511691000371 E3 interaction surface; other site 511691000372 lipoyl attachment site [posttranslational modification]; other site 511691000373 e3 binding domain; Region: E3_binding; pfam02817 511691000374 e3 binding domain; Region: E3_binding; pfam02817 511691000375 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 511691000376 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 511691000377 E3 interaction surface; other site 511691000378 lipoyl attachment site [posttranslational modification]; other site 511691000379 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 511691000380 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 511691000381 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 511691000382 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 511691000383 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 511691000384 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 511691000385 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 511691000386 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 511691000387 metal binding site [ion binding]; metal-binding site 511691000388 dimer interface [polypeptide binding]; other site 511691000389 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511691000390 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511691000391 putative substrate translocation pore; other site 511691000392 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 511691000393 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 511691000394 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 511691000395 active site 511691000396 catalytic residues [active] 511691000397 metal binding site [ion binding]; metal-binding site 511691000398 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 511691000399 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 511691000400 ligand binding site [chemical binding]; other site 511691000401 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 511691000402 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511691000403 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 511691000404 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 511691000405 putative catalytic cysteine [active] 511691000406 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 511691000407 putative active site [active] 511691000408 metal binding site [ion binding]; metal-binding site 511691000409 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 511691000410 16S/18S rRNA binding site [nucleotide binding]; other site 511691000411 S13e-L30e interaction site [polypeptide binding]; other site 511691000412 25S rRNA binding site [nucleotide binding]; other site 511691000413 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 511691000414 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 511691000415 RNase E interface [polypeptide binding]; other site 511691000416 trimer interface [polypeptide binding]; other site 511691000417 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 511691000418 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 511691000419 RNase E interface [polypeptide binding]; other site 511691000420 trimer interface [polypeptide binding]; other site 511691000421 active site 511691000422 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 511691000423 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 511691000424 RNA binding site [nucleotide binding]; other site 511691000425 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 511691000426 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 511691000427 trimer interface [polypeptide binding]; other site 511691000428 active site 511691000429 substrate binding site [chemical binding]; other site 511691000430 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 511691000431 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 511691000432 active site 511691000433 HIGH motif; other site 511691000434 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 511691000435 KMSKS motif; other site 511691000436 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 511691000437 tRNA binding surface [nucleotide binding]; other site 511691000438 anticodon binding site; other site 511691000439 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 511691000440 active site 511691000441 metal binding site [ion binding]; metal-binding site 511691000442 dimerization interface [polypeptide binding]; other site 511691000443 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 511691000444 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 511691000445 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 511691000446 DNA binding residues [nucleotide binding] 511691000447 dimer interface [polypeptide binding]; other site 511691000448 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 511691000449 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 511691000450 Predicted transcriptional regulators [Transcription]; Region: COG1695 511691000451 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 511691000452 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 511691000453 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 511691000454 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 511691000455 EDD domain protein, DegV family; Region: DegV; TIGR00762 511691000456 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 511691000457 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 511691000458 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511691000459 non-specific DNA binding site [nucleotide binding]; other site 511691000460 salt bridge; other site 511691000461 sequence-specific DNA binding site [nucleotide binding]; other site 511691000462 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 511691000463 23S rRNA interface [nucleotide binding]; other site 511691000464 L3 interface [polypeptide binding]; other site 511691000465 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 511691000466 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 511691000467 PemK-like protein; Region: PemK; pfam02452 511691000468 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 511691000469 PGAP1-like protein; Region: PGAP1; pfam07819 511691000470 Predicted flavoprotein [General function prediction only]; Region: COG0431 511691000471 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 511691000472 Predicted flavoprotein [General function prediction only]; Region: COG0431 511691000473 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 511691000474 FMN-binding domain; Region: FMN_bind; cl01081 511691000475 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 511691000476 L-aspartate oxidase; Provisional; Region: PRK06175 511691000477 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 511691000478 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 511691000479 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 511691000480 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 511691000481 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 511691000482 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 511691000483 ABC-ATPase subunit interface; other site 511691000484 dimer interface [polypeptide binding]; other site 511691000485 putative PBP binding regions; other site 511691000486 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 511691000487 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 511691000488 metal binding site [ion binding]; metal-binding site 511691000489 frameshift of SMU.185 511691000490 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 511691000491 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 511691000492 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 511691000493 FeoA domain; Region: FeoA; pfam04023 511691000494 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 511691000495 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 511691000496 FMN binding site [chemical binding]; other site 511691000497 active site 511691000498 catalytic residues [active] 511691000499 substrate binding site [chemical binding]; other site 511691000500 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 511691000501 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 511691000502 dimerization interface [polypeptide binding]; other site 511691000503 domain crossover interface; other site 511691000504 redox-dependent activation switch; other site 511691000505 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 511691000506 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 511691000507 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 511691000508 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 511691000509 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 511691000510 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 511691000511 putative Zn2+ binding site [ion binding]; other site 511691000512 putative DNA binding site [nucleotide binding]; other site 511691000513 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 511691000514 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 511691000515 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 511691000516 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 511691000517 ABC-ATPase subunit interface; other site 511691000518 dimer interface [polypeptide binding]; other site 511691000519 putative PBP binding regions; other site 511691000520 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 511691000521 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 511691000522 active site 511691000523 HIGH motif; other site 511691000524 dimer interface [polypeptide binding]; other site 511691000525 KMSKS motif; other site 511691000526 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 511691000527 RNA binding surface [nucleotide binding]; other site 511691000528 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 511691000529 Transglycosylase; Region: Transgly; pfam00912 511691000530 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 511691000531 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 511691000532 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 511691000533 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 511691000534 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 511691000535 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 511691000536 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 511691000537 RPB1 interaction site [polypeptide binding]; other site 511691000538 RPB10 interaction site [polypeptide binding]; other site 511691000539 RPB11 interaction site [polypeptide binding]; other site 511691000540 RPB3 interaction site [polypeptide binding]; other site 511691000541 RPB12 interaction site [polypeptide binding]; other site 511691000542 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 511691000543 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 511691000544 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 511691000545 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 511691000546 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 511691000547 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 511691000548 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 511691000549 G-loop; other site 511691000550 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 511691000551 DNA binding site [nucleotide binding] 511691000552 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 511691000553 Protein of unknown function (DUF1033); Region: DUF1033; pfam06279 511691000554 Type II/IV secretion system protein; Region: T2SE; pfam00437 511691000555 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 511691000556 Walker A motif; other site 511691000557 ATP binding site [chemical binding]; other site 511691000558 Walker B motif; other site 511691000559 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 511691000560 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 511691000561 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 511691000562 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 511691000563 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 511691000564 Type II secretory pathway pseudopilin; Region: PulG; pfam11773 511691000565 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 511691000566 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 511691000567 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511691000568 S-adenosylmethionine binding site [chemical binding]; other site 511691000569 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 511691000570 propionate/acetate kinase; Provisional; Region: PRK12379 511691000571 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511691000572 non-specific DNA binding site [nucleotide binding]; other site 511691000573 salt bridge; other site 511691000574 sequence-specific DNA binding site [nucleotide binding]; other site 511691000575 CAAX protease self-immunity; Region: Abi; pfam02517 511691000576 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 511691000577 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 511691000578 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 511691000579 glutamyl aminopeptidase; Region: glu_aminopep; TIGR03107 511691000580 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 511691000581 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 511691000582 catalytic residues [active] 511691000583 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 511691000584 putative tRNA-binding site [nucleotide binding]; other site 511691000585 MarR family; Region: MarR_2; cl17246 511691000586 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 511691000587 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 511691000588 active site residue [active] 511691000589 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 511691000590 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 511691000591 dimer interface [polypeptide binding]; other site 511691000592 ssDNA binding site [nucleotide binding]; other site 511691000593 tetramer (dimer of dimers) interface [polypeptide binding]; other site 511691000594 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 511691000595 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 511691000596 ligand binding site [chemical binding]; other site 511691000597 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 511691000598 Histidine kinase; Region: HisKA_3; pfam07730 511691000599 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 511691000600 ATP binding site [chemical binding]; other site 511691000601 Mg2+ binding site [ion binding]; other site 511691000602 G-X-G motif; other site 511691000603 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 511691000604 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511691000605 active site 511691000606 phosphorylation site [posttranslational modification] 511691000607 intermolecular recognition site; other site 511691000608 dimerization interface [polypeptide binding]; other site 511691000609 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 511691000610 DNA binding residues [nucleotide binding] 511691000611 dimerization interface [polypeptide binding]; other site 511691000612 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 511691000613 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 511691000614 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 511691000615 active pocket/dimerization site; other site 511691000616 active site 511691000617 phosphorylation site [posttranslational modification] 511691000618 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 511691000619 active site 511691000620 phosphorylation site [posttranslational modification] 511691000621 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 511691000622 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 511691000623 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 511691000624 oligomerisation interface [polypeptide binding]; other site 511691000625 mobile loop; other site 511691000626 roof hairpin; other site 511691000627 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 511691000628 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 511691000629 ring oligomerisation interface [polypeptide binding]; other site 511691000630 ATP/Mg binding site [chemical binding]; other site 511691000631 stacking interactions; other site 511691000632 hinge regions; other site 511691000633 Predicted membrane protein [Function unknown]; Region: COG4640 511691000634 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 511691000635 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 511691000636 active site 511691000637 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 511691000638 Transglycosylase; Region: Transgly; pfam00912 511691000639 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 511691000640 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 511691000641 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 511691000642 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 511691000643 putative homodimer interface [polypeptide binding]; other site 511691000644 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 511691000645 heterodimer interface [polypeptide binding]; other site 511691000646 homodimer interface [polypeptide binding]; other site 511691000647 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 511691000648 putative metal binding residues [ion binding]; other site 511691000649 signature motif; other site 511691000650 dimer interface [polypeptide binding]; other site 511691000651 active site 511691000652 polyP binding site; other site 511691000653 substrate binding site [chemical binding]; other site 511691000654 acceptor-phosphate pocket; other site 511691000655 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 511691000656 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 511691000657 HIGH motif; other site 511691000658 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 511691000659 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 511691000660 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 511691000661 active site 511691000662 KMSKS motif; other site 511691000663 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 511691000664 tRNA binding surface [nucleotide binding]; other site 511691000665 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 511691000666 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 511691000667 substrate binding pocket [chemical binding]; other site 511691000668 membrane-bound complex binding site; other site 511691000669 hinge residues; other site 511691000670 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 511691000671 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 511691000672 hypothetical protein; Provisional; Region: PRK06446 511691000673 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 511691000674 metal binding site [ion binding]; metal-binding site 511691000675 dimer interface [polypeptide binding]; other site 511691000676 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 511691000677 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 511691000678 Walker A/P-loop; other site 511691000679 ATP binding site [chemical binding]; other site 511691000680 Q-loop/lid; other site 511691000681 ABC transporter signature motif; other site 511691000682 Walker B; other site 511691000683 D-loop; other site 511691000684 H-loop/switch region; other site 511691000685 NIL domain; Region: NIL; pfam09383 511691000686 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 511691000687 dimer interface [polypeptide binding]; other site 511691000688 conserved gate region; other site 511691000689 ABC-ATPase subunit interface; other site 511691000690 Predicted amidohydrolase [General function prediction only]; Region: COG0388 511691000691 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 511691000692 putative active site [active] 511691000693 catalytic triad [active] 511691000694 putative dimer interface [polypeptide binding]; other site 511691000695 Uncharacterized conserved protein [Function unknown]; Region: COG1912 511691000696 hypothetical protein; Provisional; Region: PRK13661 511691000697 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 511691000698 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 511691000699 Walker A/P-loop; other site 511691000700 ATP binding site [chemical binding]; other site 511691000701 Q-loop/lid; other site 511691000702 ABC transporter signature motif; other site 511691000703 Walker B; other site 511691000704 D-loop; other site 511691000705 H-loop/switch region; other site 511691000706 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 511691000707 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 511691000708 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 511691000709 Walker A/P-loop; other site 511691000710 ATP binding site [chemical binding]; other site 511691000711 Q-loop/lid; other site 511691000712 ABC transporter signature motif; other site 511691000713 Walker B; other site 511691000714 D-loop; other site 511691000715 H-loop/switch region; other site 511691000716 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 511691000717 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 511691000718 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511691000719 S-adenosylmethionine binding site [chemical binding]; other site 511691000720 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 511691000721 heat shock protein HtpX; Provisional; Region: PRK04897 511691000722 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 511691000723 FtsX-like permease family; Region: FtsX; pfam02687 511691000724 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 511691000725 FtsX-like permease family; Region: FtsX; pfam02687 511691000726 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 511691000727 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 511691000728 Walker A/P-loop; other site 511691000729 ATP binding site [chemical binding]; other site 511691000730 Q-loop/lid; other site 511691000731 ABC transporter signature motif; other site 511691000732 Walker B; other site 511691000733 D-loop; other site 511691000734 H-loop/switch region; other site 511691000735 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 511691000736 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 511691000737 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 511691000738 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 511691000739 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 511691000740 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511691000741 active site 511691000742 phosphorylation site [posttranslational modification] 511691000743 intermolecular recognition site; other site 511691000744 dimerization interface [polypeptide binding]; other site 511691000745 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 511691000746 DNA binding site [nucleotide binding] 511691000747 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 511691000748 ATP cone domain; Region: ATP-cone; pfam03477 511691000749 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 511691000750 primosomal protein DnaI; Reviewed; Region: PRK08939 511691000751 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 511691000752 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511691000753 Walker A motif; other site 511691000754 ATP binding site [chemical binding]; other site 511691000755 Walker B motif; other site 511691000756 GTP-binding protein Der; Reviewed; Region: PRK00093 511691000757 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 511691000758 G1 box; other site 511691000759 GTP/Mg2+ binding site [chemical binding]; other site 511691000760 Switch I region; other site 511691000761 G2 box; other site 511691000762 Switch II region; other site 511691000763 G3 box; other site 511691000764 G4 box; other site 511691000765 G5 box; other site 511691000766 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 511691000767 G1 box; other site 511691000768 GTP/Mg2+ binding site [chemical binding]; other site 511691000769 Switch I region; other site 511691000770 G2 box; other site 511691000771 G3 box; other site 511691000772 Switch II region; other site 511691000773 G4 box; other site 511691000774 G5 box; other site 511691000775 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 511691000776 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 511691000777 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 511691000778 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511691000779 active site 511691000780 phosphorylation site [posttranslational modification] 511691000781 intermolecular recognition site; other site 511691000782 dimerization interface [polypeptide binding]; other site 511691000783 LytTr DNA-binding domain; Region: LytTR; pfam04397 511691000784 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 511691000785 COMC family; Region: ComC; pfam03047 511691000786 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 511691000787 IS861 fragment 511691000788 COMC family; Region: ComC; pfam03047 511691000789 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 511691000790 catalytic residues [active] 511691000791 HlyD family secretion protein; Region: HlyD_3; pfam13437 511691000792 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 511691000793 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 511691000794 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511691000795 Walker A/P-loop; other site 511691000796 ATP binding site [chemical binding]; other site 511691000797 Q-loop/lid; other site 511691000798 ABC transporter signature motif; other site 511691000799 Walker B; other site 511691000800 D-loop; other site 511691000801 H-loop/switch region; other site 511691000802 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 511691000803 putative active site [active] 511691000804 COMC family; Region: ComC; pfam03047 511691000805 Integrase core domain; Region: rve_3; cl15866 511691000806 seryl-tRNA synthetase; Provisional; Region: PRK05431 511691000807 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 511691000808 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 511691000809 dimer interface [polypeptide binding]; other site 511691000810 active site 511691000811 motif 1; other site 511691000812 motif 2; other site 511691000813 motif 3; other site 511691000814 Acyltransferase family; Region: Acyl_transf_3; pfam01757 511691000815 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 511691000816 Domain of unknown function (DUF956); Region: DUF956; pfam06115 511691000817 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 511691000818 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 511691000819 putative active site [active] 511691000820 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 511691000821 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511691000822 Walker A/P-loop; other site 511691000823 ATP binding site [chemical binding]; other site 511691000824 Q-loop/lid; other site 511691000825 ABC transporter signature motif; other site 511691000826 Walker B; other site 511691000827 D-loop; other site 511691000828 H-loop/switch region; other site 511691000829 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 511691000830 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 511691000831 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 511691000832 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 511691000833 active pocket/dimerization site; other site 511691000834 active site 511691000835 phosphorylation site [posttranslational modification] 511691000836 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 511691000837 active site 511691000838 phosphorylation site [posttranslational modification] 511691000839 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 511691000840 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 511691000841 DNA binding site [nucleotide binding] 511691000842 AAA domain; Region: AAA_30; pfam13604 511691000843 Family description; Region: UvrD_C_2; pfam13538 511691000844 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 511691000845 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 511691000846 Catalytic site [active] 511691000847 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 511691000848 ribonuclease HIII; Provisional; Region: PRK00996 511691000849 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 511691000850 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 511691000851 RNA/DNA hybrid binding site [nucleotide binding]; other site 511691000852 active site 511691000853 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 511691000854 Colicin V production protein; Region: Colicin_V; pfam02674 511691000855 CAAX protease self-immunity; Region: Abi; pfam02517 511691000856 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 511691000857 MutS domain III; Region: MutS_III; pfam05192 511691000858 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 511691000859 Walker A/P-loop; other site 511691000860 ATP binding site [chemical binding]; other site 511691000861 Q-loop/lid; other site 511691000862 ABC transporter signature motif; other site 511691000863 Walker B; other site 511691000864 D-loop; other site 511691000865 H-loop/switch region; other site 511691000866 Smr domain; Region: Smr; pfam01713 511691000867 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 511691000868 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 511691000869 catalytic residues [active] 511691000870 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 511691000871 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 511691000872 catalytic Zn binding site [ion binding]; other site 511691000873 NAD(P) binding site [chemical binding]; other site 511691000874 structural Zn binding site [ion binding]; other site 511691000875 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 511691000876 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 511691000877 minor groove reading motif; other site 511691000878 helix-hairpin-helix signature motif; other site 511691000879 substrate binding pocket [chemical binding]; other site 511691000880 active site 511691000881 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 511691000882 DNA binding and oxoG recognition site [nucleotide binding] 511691000883 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 511691000884 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 511691000885 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 511691000886 ssDNA binding site [nucleotide binding]; other site 511691000887 dimer interface [polypeptide binding]; other site 511691000888 tetramer (dimer of dimers) interface [polypeptide binding]; other site 511691000889 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 511691000890 IS861 fragment 511691000891 TraX protein; Region: TraX; cl05434 511691000892 LytTr DNA-binding domain; Region: LytTR; pfam04397 511691000893 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 511691000894 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 511691000895 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 511691000896 Cl binding site [ion binding]; other site 511691000897 oligomer interface [polypeptide binding]; other site 511691000898 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 511691000899 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 511691000900 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 511691000901 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 511691000902 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 511691000903 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 511691000904 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 511691000905 active site 511691000906 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 511691000907 catalytic motif [active] 511691000908 Zn binding site [ion binding]; other site 511691000909 Ion transport protein; Region: Ion_trans; pfam00520 511691000910 Ion channel; Region: Ion_trans_2; pfam07885 511691000911 elongation factor P; Validated; Region: PRK00529 511691000912 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 511691000913 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 511691000914 RNA binding site [nucleotide binding]; other site 511691000915 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 511691000916 RNA binding site [nucleotide binding]; other site 511691000917 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 511691000918 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 511691000919 putative RNA binding site [nucleotide binding]; other site 511691000920 Transcriptional regulators [Transcription]; Region: PurR; COG1609 511691000921 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 511691000922 DNA binding site [nucleotide binding] 511691000923 domain linker motif; other site 511691000924 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 511691000925 dimerization interface [polypeptide binding]; other site 511691000926 ligand binding site [chemical binding]; other site 511691000927 sodium binding site [ion binding]; other site 511691000928 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 511691000929 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 511691000930 substrate binding [chemical binding]; other site 511691000931 active site 511691000932 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 511691000933 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 511691000934 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 511691000935 active site turn [active] 511691000936 phosphorylation site [posttranslational modification] 511691000937 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 511691000938 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 511691000939 HPr interaction site; other site 511691000940 glycerol kinase (GK) interaction site [polypeptide binding]; other site 511691000941 active site 511691000942 phosphorylation site [posttranslational modification] 511691000943 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 511691000944 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 511691000945 nucleotide binding site [chemical binding]; other site 511691000946 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 511691000947 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 511691000948 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 511691000949 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 511691000950 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511691000951 nucleotide binding region [chemical binding]; other site 511691000952 ATP-binding site [chemical binding]; other site 511691000953 SEC-C motif; Region: SEC-C; pfam02810 511691000954 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; cl17260 511691000955 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 511691000956 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 511691000957 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 511691000958 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 511691000959 alanine racemase; Reviewed; Region: alr; PRK00053 511691000960 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 511691000961 active site 511691000962 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 511691000963 dimer interface [polypeptide binding]; other site 511691000964 substrate binding site [chemical binding]; other site 511691000965 catalytic residues [active] 511691000966 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 511691000967 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 511691000968 generic binding surface II; other site 511691000969 ssDNA binding site; other site 511691000970 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 511691000971 ATP binding site [chemical binding]; other site 511691000972 putative Mg++ binding site [ion binding]; other site 511691000973 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511691000974 nucleotide binding region [chemical binding]; other site 511691000975 ATP-binding site [chemical binding]; other site 511691000976 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 511691000977 active site 511691000978 homotetramer interface [polypeptide binding]; other site 511691000979 homodimer interface [polypeptide binding]; other site 511691000980 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511691000981 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 511691000982 active site 511691000983 motif I; other site 511691000984 motif II; other site 511691000985 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511691000986 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4696 511691000987 metal binding site [ion binding]; metal-binding site 511691000988 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 511691000989 Ligand Binding Site [chemical binding]; other site 511691000990 BioY family; Region: BioY; pfam02632 511691000991 aminotransferase AlaT; Validated; Region: PRK09265 511691000992 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 511691000993 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511691000994 homodimer interface [polypeptide binding]; other site 511691000995 catalytic residue [active] 511691000996 transcriptional repressor CodY; Validated; Region: PRK04158 511691000997 CodY GAF-like domain; Region: CodY; pfam06018 511691000998 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 511691000999 dimerization interface [polypeptide binding]; other site 511691001000 putative Zn2+ binding site [ion binding]; other site 511691001001 putative DNA binding site [nucleotide binding]; other site 511691001002 Isochorismatase family; Region: Isochorismatase; pfam00857 511691001003 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 511691001004 catalytic triad [active] 511691001005 conserved cis-peptide bond; other site 511691001006 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 511691001007 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 511691001008 dimer interface [polypeptide binding]; other site 511691001009 anticodon binding site; other site 511691001010 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 511691001011 homodimer interface [polypeptide binding]; other site 511691001012 motif 1; other site 511691001013 active site 511691001014 motif 2; other site 511691001015 GAD domain; Region: GAD; pfam02938 511691001016 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 511691001017 active site 511691001018 motif 3; other site 511691001019 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 511691001020 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 511691001021 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 511691001022 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 511691001023 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 511691001024 GatB domain; Region: GatB_Yqey; pfam02637 511691001025 ISSpy1 511691001026 frameshift mutation 511691001027 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 511691001028 nucleic acid binding site [nucleotide binding]; other site 511691001029 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 511691001030 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 511691001031 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511691001032 active site 511691001033 phosphorylation site [posttranslational modification] 511691001034 intermolecular recognition site; other site 511691001035 dimerization interface [polypeptide binding]; other site 511691001036 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 511691001037 DNA binding site [nucleotide binding] 511691001038 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 511691001039 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 511691001040 dimer interface [polypeptide binding]; other site 511691001041 phosphorylation site [posttranslational modification] 511691001042 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511691001043 ATP binding site [chemical binding]; other site 511691001044 Mg2+ binding site [ion binding]; other site 511691001045 G-X-G motif; other site 511691001046 IS1193D 511691001047 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 511691001048 Helix-turn-helix domain; Region: HTH_38; pfam13936 511691001049 Transposase; Region: DDE_Tnp_ISL3; pfam01610 511691001050 ISSth1 fragment 511691001051 Type-A lantibiotic; Region: L_biotic_typeA; pfam04604 511691001052 Type-A lantibiotic; Region: L_biotic_typeA; pfam04604 511691001053 Type-A lantibiotic; Region: L_biotic_typeA; pfam04604 511691001054 Type-A lantibiotic; Region: L_biotic_typeA; pfam04604 511691001055 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 511691001056 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 511691001057 active site 511691001058 zinc binding site [ion binding]; other site 511691001059 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 511691001060 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39F; cd02425 511691001061 putative active site [active] 511691001062 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 511691001063 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511691001064 Walker A/P-loop; other site 511691001065 ATP binding site [chemical binding]; other site 511691001066 Q-loop/lid; other site 511691001067 ABC transporter signature motif; other site 511691001068 Walker B; other site 511691001069 D-loop; other site 511691001070 H-loop/switch region; other site 511691001071 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 511691001072 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511691001073 Walker A/P-loop; other site 511691001074 ATP binding site [chemical binding]; other site 511691001075 Q-loop/lid; other site 511691001076 ABC transporter signature motif; other site 511691001077 Walker B; other site 511691001078 D-loop; other site 511691001079 H-loop/switch region; other site 511691001080 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 511691001081 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 511691001082 EamA-like transporter family; Region: EamA; pfam00892 511691001083 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 511691001084 glycosyltransferase, MGT family; Region: MGT; TIGR01426 511691001085 active site 511691001086 TDP-binding site; other site 511691001087 acceptor substrate-binding pocket; other site 511691001088 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 511691001089 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 511691001090 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 511691001091 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 511691001092 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511691001093 active site 511691001094 motif I; other site 511691001095 motif II; other site 511691001096 GTPase YqeH; Provisional; Region: PRK13796 511691001097 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 511691001098 GTP/Mg2+ binding site [chemical binding]; other site 511691001099 G4 box; other site 511691001100 G5 box; other site 511691001101 G1 box; other site 511691001102 Switch I region; other site 511691001103 G2 box; other site 511691001104 G3 box; other site 511691001105 Switch II region; other site 511691001106 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 511691001107 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 511691001108 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 511691001109 active site 511691001110 (T/H)XGH motif; other site 511691001111 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 511691001112 Zn2+ binding site [ion binding]; other site 511691001113 Mg2+ binding site [ion binding]; other site 511691001114 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 511691001115 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 511691001116 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511691001117 S-adenosylmethionine binding site [chemical binding]; other site 511691001118 hypothetical protein; Provisional; Region: PRK13670 511691001119 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 511691001120 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 511691001121 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 511691001122 DNA binding residues [nucleotide binding] 511691001123 dimer interface [polypeptide binding]; other site 511691001124 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 511691001125 hypothetical protein; Provisional; Region: PRK12378 511691001126 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 511691001127 catalytic residues [active] 511691001128 preprotein translocase subunit YajC; Validated; Region: yajC; PRK06531 511691001129 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 511691001130 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 511691001131 catalytic residue [active] 511691001132 putative FPP diphosphate binding site; other site 511691001133 putative FPP binding hydrophobic cleft; other site 511691001134 dimer interface [polypeptide binding]; other site 511691001135 putative IPP diphosphate binding site; other site 511691001136 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 511691001137 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 511691001138 RIP metalloprotease RseP; Region: TIGR00054 511691001139 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 511691001140 active site 511691001141 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 511691001142 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 511691001143 protein binding site [polypeptide binding]; other site 511691001144 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 511691001145 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 511691001146 putative substrate binding region [chemical binding]; other site 511691001147 prolyl-tRNA synthetase; Provisional; Region: PRK09194 511691001148 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 511691001149 dimer interface [polypeptide binding]; other site 511691001150 motif 1; other site 511691001151 active site 511691001152 motif 2; other site 511691001153 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 511691001154 putative deacylase active site [active] 511691001155 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 511691001156 active site 511691001157 motif 3; other site 511691001158 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 511691001159 anticodon binding site; other site 511691001160 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 511691001161 hypothetical protein; Provisional; Region: PRK13662 511691001162 recombination regulator RecX; Provisional; Region: recX; PRK14135 511691001163 TRAM domain; Region: TRAM; cl01282 511691001164 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 511691001165 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 511691001166 flavoprotein NrdI; Provisional; Region: PRK02551 511691001167 Domain of unknown function (DUF1912); Region: DUF1912; pfam08930 511691001168 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 511691001169 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 511691001170 Methyltransferase domain; Region: Methyltransf_26; pfam13659 511691001171 Virulence protein [General function prediction only]; Region: COG3943 511691001172 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 511691001173 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 511691001174 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 511691001175 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 511691001176 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 511691001177 Part of AAA domain; Region: AAA_19; pfam13245 511691001178 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 511691001179 AAA domain; Region: AAA_12; pfam13087 511691001180 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 511691001181 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 511691001182 active site 511691001183 HIGH motif; other site 511691001184 nucleotide binding site [chemical binding]; other site 511691001185 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 511691001186 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 511691001187 active site 511691001188 KMSKS motif; other site 511691001189 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 511691001190 tRNA binding surface [nucleotide binding]; other site 511691001191 anticodon binding site; other site 511691001192 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 511691001193 deoxyguanosinetriphosphate triphosphohydrolase, putative; Region: dGTP_triPase; TIGR01353 511691001194 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 511691001195 Zn2+ binding site [ion binding]; other site 511691001196 Mg2+ binding site [ion binding]; other site 511691001197 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 511691001198 SERine Proteinase INhibitors (serpins) exhibit conformational polymorphism shifting from native to cleaved, latent, delta, or polymorphic forms. Many serpins, such as antitrypsin and antichymotrypsin, function as serine protease inhibitors which regulate...; Region: SERPIN; cl00137 511691001199 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 511691001200 VbhA antitoxin and related proteins; Region: VbhA_like; cd11586 511691001201 FIC domain binding interface [polypeptide binding]; other site 511691001202 Fic/DOC family; Region: Fic; pfam02661 511691001203 aspartate kinase; Reviewed; Region: PRK09034 511691001204 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 511691001205 putative catalytic residues [active] 511691001206 putative nucleotide binding site [chemical binding]; other site 511691001207 putative aspartate binding site [chemical binding]; other site 511691001208 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 511691001209 allosteric regulatory residue; other site 511691001210 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 511691001211 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 511691001212 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511691001213 motif II; other site 511691001214 enoyl-CoA hydratase; Provisional; Region: PRK07260 511691001215 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 511691001216 substrate binding site [chemical binding]; other site 511691001217 oxyanion hole (OAH) forming residues; other site 511691001218 trimer interface [polypeptide binding]; other site 511691001219 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 511691001220 MarR family; Region: MarR_2; pfam12802 511691001221 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 511691001222 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 511691001223 dimer interface [polypeptide binding]; other site 511691001224 active site 511691001225 CoA binding pocket [chemical binding]; other site 511691001226 acyl carrier protein; Provisional; Region: acpP; PRK00982 511691001227 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 511691001228 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 511691001229 FMN binding site [chemical binding]; other site 511691001230 substrate binding site [chemical binding]; other site 511691001231 putative catalytic residue [active] 511691001232 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 511691001233 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 511691001234 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 511691001235 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511691001236 NAD(P) binding site [chemical binding]; other site 511691001237 active site 511691001238 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 511691001239 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 511691001240 dimer interface [polypeptide binding]; other site 511691001241 active site 511691001242 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 511691001243 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 511691001244 carboxyltransferase (CT) interaction site; other site 511691001245 biotinylation site [posttranslational modification]; other site 511691001246 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 511691001247 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 511691001248 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 511691001249 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 511691001250 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 511691001251 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 511691001252 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 511691001253 acetyl-CoA carboxylase subunit alpha; Provisional; Region: PRK12319 511691001254 SWIM zinc finger; Region: SWIM; pfam04434 511691001255 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 511691001256 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 511691001257 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 511691001258 ATP binding site [chemical binding]; other site 511691001259 putative Mg++ binding site [ion binding]; other site 511691001260 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 511691001261 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511691001262 nucleotide binding region [chemical binding]; other site 511691001263 ATP-binding site [chemical binding]; other site 511691001264 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 511691001265 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 511691001266 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 511691001267 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 511691001268 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 511691001269 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511691001270 Coenzyme A binding pocket [chemical binding]; other site 511691001271 YceG-like family; Region: YceG; pfam02618 511691001272 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 511691001273 dimerization interface [polypeptide binding]; other site 511691001274 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 511691001275 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 511691001276 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 511691001277 OxaA-like protein precursor; Provisional; Region: PRK02463 511691001278 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 511691001279 acylphosphatase; Provisional; Region: PRK14434 511691001280 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 511691001281 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 511691001282 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 511691001283 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 511691001284 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 511691001285 Zn2+ binding site [ion binding]; other site 511691001286 Mg2+ binding site [ion binding]; other site 511691001287 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 511691001288 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 511691001289 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 511691001290 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 511691001291 active site 511691001292 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 511691001293 substrate binding site [chemical binding]; other site 511691001294 catalytic residues [active] 511691001295 dimer interface [polypeptide binding]; other site 511691001296 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 511691001297 glutamate racemase; Provisional; Region: PRK00865 511691001298 putative deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein; Reviewed; Region: PRK02491 511691001299 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 511691001300 active site 511691001301 dimerization interface [polypeptide binding]; other site 511691001302 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 511691001303 active site 511691001304 metal binding site [ion binding]; metal-binding site 511691001305 homotetramer interface [polypeptide binding]; other site 511691001306 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 511691001307 FOG: CBS domain [General function prediction only]; Region: COG0517 511691001308 site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436 511691001309 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 511691001310 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 511691001311 active site 511691001312 catalytic residues [active] 511691001313 DNA binding site [nucleotide binding] 511691001314 Int/Topo IB signature motif; other site 511691001315 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 511691001316 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 511691001317 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 511691001318 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 511691001319 RNA binding surface [nucleotide binding]; other site 511691001320 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 511691001321 active site 511691001322 hypothetical protein; Validated; Region: PRK00041 511691001323 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 511691001324 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 511691001325 TrkA-N domain; Region: TrkA_N; pfam02254 511691001326 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 511691001327 TrkA-C domain; Region: TrkA_C; pfam02080 511691001328 TrkA-N domain; Region: TrkA_N; pfam02254 511691001329 TrkA-C domain; Region: TrkA_C; pfam02080 511691001330 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 511691001331 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 511691001332 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 511691001333 Predicted membrane protein [Function unknown]; Region: COG4709 511691001334 Predicted transcriptional regulators [Transcription]; Region: COG1695 511691001335 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 511691001336 Predicted membrane protein [Function unknown]; Region: COG3601 511691001337 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 511691001338 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 511691001339 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 511691001340 active site 511691001341 LrgA family; Region: LrgA; pfam03788 511691001342 LrgB-like family; Region: LrgB; pfam04172 511691001343 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 511691001344 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 511691001345 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 511691001346 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511691001347 Walker A/P-loop; other site 511691001348 ATP binding site [chemical binding]; other site 511691001349 Q-loop/lid; other site 511691001350 ABC transporter signature motif; other site 511691001351 Walker B; other site 511691001352 D-loop; other site 511691001353 H-loop/switch region; other site 511691001354 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 511691001355 Domain of unknown function DUF20; Region: UPF0118; pfam01594 511691001356 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 511691001357 Domain of unknown function DUF21; Region: DUF21; pfam01595 511691001358 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 511691001359 Transporter associated domain; Region: CorC_HlyC; smart01091 511691001360 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 511691001361 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511691001362 FeS/SAM binding site; other site 511691001363 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 511691001364 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 511691001365 acyl-activating enzyme (AAE) consensus motif; other site 511691001366 AMP binding site [chemical binding]; other site 511691001367 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 511691001368 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 511691001369 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 511691001370 DltD N-terminal region; Region: DltD_N; pfam04915 511691001371 DltD central region; Region: DltD_M; pfam04918 511691001372 DltD C-terminal region; Region: DltD_C; pfam04914 511691001373 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 511691001374 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 511691001375 DHHA2 domain; Region: DHHA2; pfam02833 511691001376 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 511691001377 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 511691001378 Predicted transcriptional regulator [Transcription]; Region: COG2378 511691001379 HTH domain; Region: HTH_11; pfam08279 511691001380 WYL domain; Region: WYL; pfam13280 511691001381 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 511691001382 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 511691001383 conserved cys residue [active] 511691001384 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 511691001385 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 511691001386 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 511691001387 substrate binding site [chemical binding]; other site 511691001388 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 511691001389 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 511691001390 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 511691001391 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 511691001392 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 511691001393 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 511691001394 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 511691001395 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 511691001396 cystathionine gamma-synthase; Reviewed; Region: PRK07269 511691001397 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 511691001398 homodimer interface [polypeptide binding]; other site 511691001399 substrate-cofactor binding pocket; other site 511691001400 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511691001401 catalytic residue [active] 511691001402 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 511691001403 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 511691001404 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511691001405 homodimer interface [polypeptide binding]; other site 511691001406 catalytic residue [active] 511691001407 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511691001408 active site 511691001409 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 511691001410 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 511691001411 oligomer interface [polypeptide binding]; other site 511691001412 active site residues [active] 511691001413 Protein of unknown function (DUF964); Region: DUF964; pfam06133 511691001414 hypothetical protein; Provisional; Region: PRK02302 511691001415 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 511691001416 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 511691001417 putative ligand binding site [chemical binding]; other site 511691001418 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 511691001419 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 511691001420 TM-ABC transporter signature motif; other site 511691001421 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 511691001422 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 511691001423 TM-ABC transporter signature motif; other site 511691001424 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 511691001425 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 511691001426 Walker A/P-loop; other site 511691001427 ATP binding site [chemical binding]; other site 511691001428 Q-loop/lid; other site 511691001429 ABC transporter signature motif; other site 511691001430 Walker B; other site 511691001431 D-loop; other site 511691001432 H-loop/switch region; other site 511691001433 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 511691001434 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 511691001435 Walker A/P-loop; other site 511691001436 ATP binding site [chemical binding]; other site 511691001437 Q-loop/lid; other site 511691001438 ABC transporter signature motif; other site 511691001439 Walker B; other site 511691001440 D-loop; other site 511691001441 H-loop/switch region; other site 511691001442 FOG: CBS domain [General function prediction only]; Region: COG0517 511691001443 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 511691001444 thymidylate kinase; Validated; Region: tmk; PRK00698 511691001445 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 511691001446 TMP-binding site; other site 511691001447 ATP-binding site [chemical binding]; other site 511691001448 DNA polymerase III subunit delta'; Validated; Region: PRK07276 511691001449 DNA polymerase III subunit delta'; Validated; Region: PRK08485 511691001450 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 511691001451 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 511691001452 Predicted methyltransferases [General function prediction only]; Region: COG0313 511691001453 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 511691001454 putative SAM binding site [chemical binding]; other site 511691001455 putative homodimer interface [polypeptide binding]; other site 511691001456 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 511691001457 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 511691001458 Nitrogen regulatory protein P-II; Region: P-II; smart00938 511691001459 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 511691001460 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 511691001461 catalytic residue [active] 511691001462 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 511691001463 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 511691001464 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511691001465 Coenzyme A binding pocket [chemical binding]; other site 511691001466 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 511691001467 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 511691001468 putative ligand binding site [chemical binding]; other site 511691001469 putative NAD binding site [chemical binding]; other site 511691001470 putative catalytic site [active] 511691001471 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 511691001472 L-serine binding site [chemical binding]; other site 511691001473 ACT domain interface; other site 511691001474 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 511691001475 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 511691001476 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 511691001477 DNA binding site [nucleotide binding] 511691001478 active site 511691001479 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 511691001480 ArsC family; Region: ArsC; pfam03960 511691001481 putative ArsC-like catalytic residues; other site 511691001482 putative TRX-like catalytic residues [active] 511691001483 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 511691001484 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 511691001485 minor groove reading motif; other site 511691001486 helix-hairpin-helix signature motif; other site 511691001487 substrate binding pocket [chemical binding]; other site 511691001488 active site 511691001489 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 511691001490 active site 511691001491 putative catalytic site [active] 511691001492 DNA binding site [nucleotide binding] 511691001493 putative phosphate binding site [ion binding]; other site 511691001494 metal binding site A [ion binding]; metal-binding site 511691001495 AP binding site [nucleotide binding]; other site 511691001496 metal binding site B [ion binding]; metal-binding site 511691001497 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 511691001498 dimerization interface [polypeptide binding]; other site 511691001499 putative DNA binding site [nucleotide binding]; other site 511691001500 putative Zn2+ binding site [ion binding]; other site 511691001501 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 511691001502 SdpI/YhfL protein family; Region: SdpI; pfam13630 511691001503 tellurite resistance protein TehB; Provisional; Region: PRK12335 511691001504 Domain of unknown function (DUF1971); Region: DUF1971; pfam09313 511691001505 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511691001506 S-adenosylmethionine binding site [chemical binding]; other site 511691001507 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 511691001508 Predicted membrane protein [Function unknown]; Region: COG2323 511691001509 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 511691001510 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 511691001511 active site 511691001512 HIGH motif; other site 511691001513 KMSKS motif; other site 511691001514 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 511691001515 tRNA binding surface [nucleotide binding]; other site 511691001516 anticodon binding site; other site 511691001517 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 511691001518 dimer interface [polypeptide binding]; other site 511691001519 putative tRNA-binding site [nucleotide binding]; other site 511691001520 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 511691001521 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 511691001522 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 511691001523 Substrate binding site; other site 511691001524 Mg++ binding site; other site 511691001525 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 511691001526 active site 511691001527 substrate binding site [chemical binding]; other site 511691001528 CoA binding site [chemical binding]; other site 511691001529 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 511691001530 dimer interface [polypeptide binding]; other site 511691001531 ADP-ribose binding site [chemical binding]; other site 511691001532 active site 511691001533 nudix motif; other site 511691001534 metal binding site [ion binding]; metal-binding site 511691001535 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 511691001536 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 511691001537 active site 511691001538 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 511691001539 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 511691001540 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 511691001541 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 511691001542 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 511691001543 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 511691001544 23S rRNA interface [nucleotide binding]; other site 511691001545 L7/L12 interface [polypeptide binding]; other site 511691001546 putative thiostrepton binding site; other site 511691001547 L25 interface [polypeptide binding]; other site 511691001548 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 511691001549 mRNA/rRNA interface [nucleotide binding]; other site 511691001550 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 511691001551 putative nucleotide binding site [chemical binding]; other site 511691001552 uridine monophosphate binding site [chemical binding]; other site 511691001553 homohexameric interface [polypeptide binding]; other site 511691001554 ribosome recycling factor; Reviewed; Region: frr; PRK00083 511691001555 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 511691001556 hinge region; other site 511691001557 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 511691001558 S1 domain; Region: S1_2; pfam13509 511691001559 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 511691001560 methionine sulfoxide reductase A; Provisional; Region: PRK14054 511691001561 hypothetical protein; Provisional; Region: PRK13672 511691001562 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 511691001563 PhoH-like protein; Region: PhoH; pfam02562 511691001564 metal-binding heat shock protein; Provisional; Region: PRK00016 511691001565 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 511691001566 GTPase Era; Reviewed; Region: era; PRK00089 511691001567 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 511691001568 G1 box; other site 511691001569 GTP/Mg2+ binding site [chemical binding]; other site 511691001570 Switch I region; other site 511691001571 G2 box; other site 511691001572 Switch II region; other site 511691001573 G3 box; other site 511691001574 G4 box; other site 511691001575 G5 box; other site 511691001576 KH domain; Region: KH_2; pfam07650 511691001577 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 511691001578 nudix motif; other site 511691001579 DinB superfamily; Region: DinB_2; pfam12867 511691001580 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 511691001581 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 511691001582 DNA binding site [nucleotide binding] 511691001583 catalytic residue [active] 511691001584 H2TH interface [polypeptide binding]; other site 511691001585 putative catalytic residues [active] 511691001586 turnover-facilitating residue; other site 511691001587 intercalation triad [nucleotide binding]; other site 511691001588 8OG recognition residue [nucleotide binding]; other site 511691001589 putative reading head residues; other site 511691001590 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 511691001591 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 511691001592 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 511691001593 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 511691001594 CoA-binding site [chemical binding]; other site 511691001595 ATP-binding [chemical binding]; other site 511691001596 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511691001597 S-adenosylmethionine binding site [chemical binding]; other site 511691001598 drug efflux system protein MdtG; Provisional; Region: PRK09874 511691001599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511691001600 putative substrate translocation pore; other site 511691001601 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 511691001602 ribonuclease R; Region: RNase_R; TIGR02063 511691001603 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 511691001604 RNB domain; Region: RNB; pfam00773 511691001605 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 511691001606 RNA binding site [nucleotide binding]; other site 511691001607 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 511691001608 SmpB-tmRNA interface; other site 511691001609 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511691001610 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511691001611 putative substrate translocation pore; other site 511691001612 Predicted transcriptional regulators [Transcription]; Region: COG1695 511691001613 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 511691001614 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 511691001615 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 511691001616 dimer interface [polypeptide binding]; other site 511691001617 active site 511691001618 metal binding site [ion binding]; metal-binding site 511691001619 glutathione binding site [chemical binding]; other site 511691001620 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 511691001621 dimer interface [polypeptide binding]; other site 511691001622 FMN binding site [chemical binding]; other site 511691001623 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 511691001624 beta-galactosidase; Region: BGL; TIGR03356 511691001625 cellobiose phosphotransferase system IIB component; Reviewed; Region: celB; PRK09590 511691001626 active site 511691001627 P-loop; other site 511691001628 phosphorylation site [posttranslational modification] 511691001629 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 511691001630 HTH domain; Region: HTH_11; pfam08279 511691001631 Mga helix-turn-helix domain; Region: Mga; pfam05043 511691001632 PRD domain; Region: PRD; pfam00874 511691001633 PRD domain; Region: PRD; pfam00874 511691001634 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 511691001635 active site 511691001636 P-loop; other site 511691001637 phosphorylation site [posttranslational modification] 511691001638 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 511691001639 active site 511691001640 phosphorylation site [posttranslational modification] 511691001641 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 511691001642 methionine cluster; other site 511691001643 active site 511691001644 phosphorylation site [posttranslational modification] 511691001645 metal binding site [ion binding]; metal-binding site 511691001646 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 511691001647 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 511691001648 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 511691001649 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 511691001650 active site 511691001651 zinc binding site [ion binding]; other site 511691001652 Putative integral membrane protein DUF46; Region: DUF46; cl17511 511691001653 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 511691001654 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 511691001655 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 511691001656 active site 511691001657 catabolite control protein A; Region: ccpA; TIGR01481 511691001658 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 511691001659 DNA binding site [nucleotide binding] 511691001660 domain linker motif; other site 511691001661 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 511691001662 dimerization interface [polypeptide binding]; other site 511691001663 effector binding site; other site 511691001664 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 511691001665 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 511691001666 active site 511691001667 Na/Ca binding site [ion binding]; other site 511691001668 catalytic site [active] 511691001669 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 511691001670 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 511691001671 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 511691001672 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 511691001673 putative ADP-binding pocket [chemical binding]; other site 511691001674 AAA domain; Region: AAA_17; pfam13207 511691001675 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 511691001676 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 511691001677 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 511691001678 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 511691001679 active site 511691001680 dimer interface [polypeptide binding]; other site 511691001681 motif 1; other site 511691001682 motif 2; other site 511691001683 motif 3; other site 511691001684 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 511691001685 anticodon binding site; other site 511691001686 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 511691001687 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 511691001688 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511691001689 Walker A motif; other site 511691001690 ATP binding site [chemical binding]; other site 511691001691 Walker B motif; other site 511691001692 arginine finger; other site 511691001693 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 511691001694 Protein of unknown function (DUF3272); Region: DUF3272; pfam11676 511691001695 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 511691001696 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 511691001697 DNA-binding site [nucleotide binding]; DNA binding site 511691001698 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 511691001699 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 511691001700 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 511691001701 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 511691001702 Domain of unknown function DUF87; Region: DUF87; pfam01935 511691001703 HerA helicase [Replication, recombination, and repair]; Region: COG0433 511691001704 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 511691001705 S-adenosylmethionine synthetase; Validated; Region: PRK05250 511691001706 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 511691001707 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 511691001708 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 511691001709 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 511691001710 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 511691001711 hinge; other site 511691001712 active site 511691001713 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 511691001714 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 511691001715 Walker A/P-loop; other site 511691001716 ATP binding site [chemical binding]; other site 511691001717 Q-loop/lid; other site 511691001718 ABC transporter signature motif; other site 511691001719 Walker B; other site 511691001720 D-loop; other site 511691001721 H-loop/switch region; other site 511691001722 TOBE domain; Region: TOBE_2; pfam08402 511691001723 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 511691001724 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511691001725 dimer interface [polypeptide binding]; other site 511691001726 conserved gate region; other site 511691001727 putative PBP binding loops; other site 511691001728 ABC-ATPase subunit interface; other site 511691001729 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511691001730 dimer interface [polypeptide binding]; other site 511691001731 conserved gate region; other site 511691001732 ABC-ATPase subunit interface; other site 511691001733 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 511691001734 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 511691001735 Transcriptional regulators [Transcription]; Region: PurR; COG1609 511691001736 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 511691001737 DNA binding site [nucleotide binding] 511691001738 domain linker motif; other site 511691001739 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 511691001740 putative dimerization interface [polypeptide binding]; other site 511691001741 putative ligand binding site [chemical binding]; other site 511691001742 4-alpha-glucanotransferase; Provisional; Region: PRK14508 511691001743 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 511691001744 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 511691001745 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 511691001746 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 511691001747 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 511691001748 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 511691001749 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 511691001750 Soluble P-type ATPase [General function prediction only]; Region: COG4087 511691001751 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 511691001752 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 511691001753 TrkA-N domain; Region: TrkA_N; pfam02254 511691001754 TrkA-C domain; Region: TrkA_C; pfam02080 511691001755 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 511691001756 TrkA-N domain; Region: TrkA_N; pfam02254 511691001757 TrkA-C domain; Region: TrkA_C; pfam02080 511691001758 Predicted membrane protein [Function unknown]; Region: COG2510 511691001759 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 511691001760 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 511691001761 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 511691001762 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 511691001763 DNA-binding site [nucleotide binding]; DNA binding site 511691001764 DRTGG domain; Region: DRTGG; pfam07085 511691001765 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 511691001766 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 511691001767 active site 511691001768 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 511691001769 EXLDI protein; Region: EXLDI; TIGR04342 511691001770 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 511691001771 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 511691001772 Walker A/P-loop; other site 511691001773 ATP binding site [chemical binding]; other site 511691001774 Q-loop/lid; other site 511691001775 ABC transporter signature motif; other site 511691001776 Walker B; other site 511691001777 D-loop; other site 511691001778 H-loop/switch region; other site 511691001779 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 511691001780 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 511691001781 Histidine kinase; Region: HisKA_3; pfam07730 511691001782 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511691001783 ATP binding site [chemical binding]; other site 511691001784 Mg2+ binding site [ion binding]; other site 511691001785 G-X-G motif; other site 511691001786 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 511691001787 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511691001788 active site 511691001789 phosphorylation site [posttranslational modification] 511691001790 intermolecular recognition site; other site 511691001791 dimerization interface [polypeptide binding]; other site 511691001792 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 511691001793 DNA binding residues [nucleotide binding] 511691001794 dimerization interface [polypeptide binding]; other site 511691001795 Predicted membrane protein [Function unknown]; Region: COG2246 511691001796 GtrA-like protein; Region: GtrA; pfam04138 511691001797 Predicted membrane protein [Function unknown]; Region: COG4708 511691001798 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 511691001799 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 511691001800 nucleotide binding pocket [chemical binding]; other site 511691001801 K-X-D-G motif; other site 511691001802 catalytic site [active] 511691001803 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 511691001804 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 511691001805 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 511691001806 Dimer interface [polypeptide binding]; other site 511691001807 BRCT sequence motif; other site 511691001808 putative lipid kinase; Reviewed; Region: PRK13055 511691001809 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 511691001810 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 511691001811 carbohydrate binding site [chemical binding]; other site 511691001812 pullulanase, type I; Region: pulA_typeI; TIGR02104 511691001813 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 511691001814 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 511691001815 Ca binding site [ion binding]; other site 511691001816 active site 511691001817 catalytic site [active] 511691001818 glycogen branching enzyme; Provisional; Region: PRK12313 511691001819 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 511691001820 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 511691001821 active site 511691001822 catalytic site [active] 511691001823 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 511691001824 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 511691001825 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 511691001826 ligand binding site; other site 511691001827 oligomer interface; other site 511691001828 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 511691001829 dimer interface [polypeptide binding]; other site 511691001830 N-terminal domain interface [polypeptide binding]; other site 511691001831 sulfate 1 binding site; other site 511691001832 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 511691001833 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 511691001834 active site 511691001835 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 511691001836 dimer interface [polypeptide binding]; other site 511691001837 N-terminal domain interface [polypeptide binding]; other site 511691001838 sulfate 1 binding site; other site 511691001839 glycogen synthase; Provisional; Region: glgA; PRK00654 511691001840 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 511691001841 ADP-binding pocket [chemical binding]; other site 511691001842 homodimer interface [polypeptide binding]; other site 511691001843 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 511691001844 homodimer interface [polypeptide binding]; other site 511691001845 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 511691001846 active site pocket [active] 511691001847 F0F1 ATP synthase subunit C; Provisional; Region: PRK13467 511691001848 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 511691001849 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 511691001850 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 511691001851 ATP synthase, F0 subunit b; Region: ATP_synt_b; TIGR01144 511691001852 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 511691001853 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 511691001854 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 511691001855 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 511691001856 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 511691001857 beta subunit interaction interface [polypeptide binding]; other site 511691001858 Walker A motif; other site 511691001859 ATP binding site [chemical binding]; other site 511691001860 Walker B motif; other site 511691001861 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 511691001862 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 511691001863 core domain interface [polypeptide binding]; other site 511691001864 delta subunit interface [polypeptide binding]; other site 511691001865 epsilon subunit interface [polypeptide binding]; other site 511691001866 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 511691001867 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 511691001868 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 511691001869 alpha subunit interaction interface [polypeptide binding]; other site 511691001870 Walker A motif; other site 511691001871 ATP binding site [chemical binding]; other site 511691001872 Walker B motif; other site 511691001873 inhibitor binding site; inhibition site 511691001874 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 511691001875 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 511691001876 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 511691001877 gamma subunit interface [polypeptide binding]; other site 511691001878 epsilon subunit interface [polypeptide binding]; other site 511691001879 LBP interface [polypeptide binding]; other site 511691001880 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 511691001881 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 511691001882 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 511691001883 hinge; other site 511691001884 active site 511691001885 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 511691001886 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 511691001887 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 511691001888 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511691001889 dimer interface [polypeptide binding]; other site 511691001890 conserved gate region; other site 511691001891 putative PBP binding loops; other site 511691001892 ABC-ATPase subunit interface; other site 511691001893 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511691001894 dimer interface [polypeptide binding]; other site 511691001895 conserved gate region; other site 511691001896 putative PBP binding loops; other site 511691001897 ABC-ATPase subunit interface; other site 511691001898 bifunctional adhesin/ABC transporter aspartate/glutamate-binding protein; Reviewed; Region: PRK11917 511691001899 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 511691001900 substrate binding pocket [chemical binding]; other site 511691001901 membrane-bound complex binding site; other site 511691001902 hinge residues; other site 511691001903 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 511691001904 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 511691001905 Walker A/P-loop; other site 511691001906 ATP binding site [chemical binding]; other site 511691001907 Q-loop/lid; other site 511691001908 ABC transporter signature motif; other site 511691001909 Walker B; other site 511691001910 D-loop; other site 511691001911 H-loop/switch region; other site 511691001912 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 511691001913 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511691001914 active site 511691001915 phosphorylation site [posttranslational modification] 511691001916 intermolecular recognition site; other site 511691001917 dimerization interface [polypeptide binding]; other site 511691001918 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 511691001919 DNA binding site [nucleotide binding] 511691001920 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 511691001921 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 511691001922 putative active site [active] 511691001923 heme pocket [chemical binding]; other site 511691001924 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 511691001925 dimer interface [polypeptide binding]; other site 511691001926 phosphorylation site [posttranslational modification] 511691001927 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511691001928 ATP binding site [chemical binding]; other site 511691001929 Mg2+ binding site [ion binding]; other site 511691001930 G-X-G motif; other site 511691001931 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 511691001932 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 511691001933 ribonuclease III; Reviewed; Region: rnc; PRK00102 511691001934 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 511691001935 dimerization interface [polypeptide binding]; other site 511691001936 active site 511691001937 metal binding site [ion binding]; metal-binding site 511691001938 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 511691001939 dsRNA binding site [nucleotide binding]; other site 511691001940 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 511691001941 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 511691001942 Walker A/P-loop; other site 511691001943 ATP binding site [chemical binding]; other site 511691001944 Q-loop/lid; other site 511691001945 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 511691001946 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 511691001947 ABC transporter signature motif; other site 511691001948 Walker B; other site 511691001949 D-loop; other site 511691001950 H-loop/switch region; other site 511691001951 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 511691001952 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 511691001953 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 511691001954 dimer interface [polypeptide binding]; other site 511691001955 motif 1; other site 511691001956 active site 511691001957 motif 2; other site 511691001958 motif 3; other site 511691001959 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 511691001960 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511691001961 Coenzyme A binding pocket [chemical binding]; other site 511691001962 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 511691001963 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 511691001964 putative tRNA-binding site [nucleotide binding]; other site 511691001965 B3/4 domain; Region: B3_4; pfam03483 511691001966 tRNA synthetase B5 domain; Region: B5; smart00874 511691001967 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 511691001968 dimer interface [polypeptide binding]; other site 511691001969 motif 1; other site 511691001970 motif 3; other site 511691001971 motif 2; other site 511691001972 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 511691001973 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 511691001974 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511691001975 non-specific DNA binding site [nucleotide binding]; other site 511691001976 salt bridge; other site 511691001977 sequence-specific DNA binding site [nucleotide binding]; other site 511691001978 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 511691001979 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511691001980 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 511691001981 FeS/SAM binding site; other site 511691001982 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 511691001983 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 511691001984 putative efflux protein, MATE family; Region: matE; TIGR00797 511691001985 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 511691001986 WYL domain; Region: WYL; pfam13280 511691001987 helicase Cas3; Provisional; Region: PRK09694 511691001988 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 511691001989 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 511691001990 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cl08044 511691001991 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09731 511691001992 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cl09608 511691001993 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 511691001994 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756 511691001995 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727 511691001996 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 511691001997 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09755 511691001998 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 511691001999 active site 511691002000 catalytic site [active] 511691002001 substrate binding site [chemical binding]; other site 511691002002 ATP-dependent nuclease subunit B; Region: rexB_recomb; TIGR02774 511691002003 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 511691002004 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 511691002005 Family description; Region: UvrD_C_2; pfam13538 511691002006 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 511691002007 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 511691002008 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 511691002009 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 511691002010 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 511691002011 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 511691002012 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 511691002013 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 511691002014 putative substrate binding site [chemical binding]; other site 511691002015 putative ATP binding site [chemical binding]; other site 511691002016 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 511691002017 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 511691002018 active site 511691002019 methionine cluster; other site 511691002020 phosphorylation site [posttranslational modification] 511691002021 metal binding site [ion binding]; metal-binding site 511691002022 phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394 511691002023 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 511691002024 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 511691002025 active site 511691002026 P-loop; other site 511691002027 phosphorylation site [posttranslational modification] 511691002028 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 511691002029 beta-galactosidase; Region: BGL; TIGR03356 511691002030 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 511691002031 active site 511691002032 catalytic residues [active] 511691002033 Protein of unknown function (DUF3884); Region: DUF3884; pfam13024 511691002034 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 511691002035 substrate binding site [chemical binding]; other site 511691002036 THF binding site; other site 511691002037 zinc-binding site [ion binding]; other site 511691002038 hypothetical protein; Provisional; Region: PRK07329 511691002039 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 511691002040 active site 511691002041 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511691002042 Walker A motif; other site 511691002043 ATP binding site [chemical binding]; other site 511691002044 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 511691002045 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 511691002046 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 511691002047 Predicted acetyltransferase [General function prediction only]; Region: COG3981 511691002048 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 511691002049 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 511691002050 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 511691002051 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 511691002052 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 511691002053 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 511691002054 HflX GTPase family; Region: HflX; cd01878 511691002055 G1 box; other site 511691002056 GTP/Mg2+ binding site [chemical binding]; other site 511691002057 Switch I region; other site 511691002058 G2 box; other site 511691002059 G3 box; other site 511691002060 Switch II region; other site 511691002061 G4 box; other site 511691002062 G5 box; other site 511691002063 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 511691002064 ribonuclease Z; Region: RNase_Z; TIGR02651 511691002065 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 511691002066 classical (c) SDRs; Region: SDR_c; cd05233 511691002067 NAD(P) binding site [chemical binding]; other site 511691002068 active site 511691002069 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 511691002070 DHH family; Region: DHH; pfam01368 511691002071 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 511691002072 Predicted transcriptional regulator [Transcription]; Region: COG2378 511691002073 HTH domain; Region: HTH_11; pfam08279 511691002074 WYL domain; Region: WYL; pfam13280 511691002075 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 511691002076 Protein of unknown function (DUF1706); Region: DUF1706; cl01748 511691002077 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511691002078 active site 511691002079 Homoserine O-succinyltransferase; Region: HTS; pfam04204 511691002080 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 511691002081 proposed active site lysine [active] 511691002082 conserved cys residue [active] 511691002083 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 511691002084 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 511691002085 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 511691002086 Family of unknown function (DUF633); Region: DUF633; pfam04816 511691002087 Uncharacterized conserved protein [Function unknown]; Region: COG0327 511691002088 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 511691002089 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 511691002090 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 511691002091 substrate binding site; other site 511691002092 tetramer interface; other site 511691002093 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 511691002094 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 511691002095 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 511691002096 NAD binding site [chemical binding]; other site 511691002097 substrate binding site [chemical binding]; other site 511691002098 homodimer interface [polypeptide binding]; other site 511691002099 active site 511691002100 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 511691002101 putative active site [active] 511691002102 nucleotide binding site [chemical binding]; other site 511691002103 nudix motif; other site 511691002104 putative metal binding site [ion binding]; other site 511691002105 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 511691002106 Domain of unknown function DUF20; Region: UPF0118; pfam01594 511691002107 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 511691002108 binding surface 511691002109 TPR motif; other site 511691002110 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 511691002111 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 511691002112 binding surface 511691002113 TPR motif; other site 511691002114 acetolactate synthase; Reviewed; Region: PRK08617 511691002115 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 511691002116 PYR/PP interface [polypeptide binding]; other site 511691002117 dimer interface [polypeptide binding]; other site 511691002118 TPP binding site [chemical binding]; other site 511691002119 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 511691002120 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 511691002121 TPP-binding site [chemical binding]; other site 511691002122 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 511691002123 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 511691002124 Spore germination protein; Region: Spore_permease; cl17796 511691002125 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 511691002126 Domain of unknown function (DUF814); Region: DUF814; pfam05670 511691002127 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 511691002128 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 511691002129 zinc binding site [ion binding]; other site 511691002130 putative ligand binding site [chemical binding]; other site 511691002131 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 511691002132 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 511691002133 TM-ABC transporter signature motif; other site 511691002134 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 511691002135 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511691002136 Walker A/P-loop; other site 511691002137 ATP binding site [chemical binding]; other site 511691002138 Q-loop/lid; other site 511691002139 ABC transporter signature motif; other site 511691002140 Walker B; other site 511691002141 D-loop; other site 511691002142 H-loop/switch region; other site 511691002143 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 511691002144 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 511691002145 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 511691002146 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 511691002147 CHY zinc finger; Region: zf-CHY; pfam05495 511691002148 S-formylglutathione hydrolase; Region: PLN02442 511691002149 Predicted esterase [General function prediction only]; Region: COG0627 511691002150 Protein of unknown function (DUF1307); Region: DUF1307; pfam06998 511691002151 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 511691002152 active site 511691002153 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 511691002154 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 511691002155 active site 511691002156 homodimer interface [polypeptide binding]; other site 511691002157 Protein gp23 (Bacteriophage A118); Region: Phage_Gp23; pfam10669 511691002158 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 511691002159 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 511691002160 DXD motif; other site 511691002161 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 511691002162 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 511691002163 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 511691002164 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 511691002165 ABC transporter; Region: ABC_tran_2; pfam12848 511691002166 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 511691002167 ABC transporter; Region: ABC_tran_2; pfam12848 511691002168 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 511691002169 catalytic triad [active] 511691002170 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 511691002171 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 511691002172 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 511691002173 Uncharacterized conserved protein [Function unknown]; Region: COG1624 511691002174 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 511691002175 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 511691002176 YbbR-like protein; Region: YbbR; pfam07949 511691002177 YbbR-like protein; Region: YbbR; pfam07949 511691002178 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 511691002179 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 511691002180 active site 511691002181 substrate binding site [chemical binding]; other site 511691002182 metal binding site [ion binding]; metal-binding site 511691002183 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 511691002184 Clp amino terminal domain; Region: Clp_N; pfam02861 511691002185 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511691002186 Walker A motif; other site 511691002187 ATP binding site [chemical binding]; other site 511691002188 Walker B motif; other site 511691002189 arginine finger; other site 511691002190 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511691002191 Walker A motif; other site 511691002192 ATP binding site [chemical binding]; other site 511691002193 Walker B motif; other site 511691002194 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 511691002195 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 511691002196 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 511691002197 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 511691002198 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 511691002199 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 511691002200 tetramer interface [polypeptide binding]; other site 511691002201 TPP-binding site [chemical binding]; other site 511691002202 heterodimer interface [polypeptide binding]; other site 511691002203 phosphorylation loop region [posttranslational modification] 511691002204 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 511691002205 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 511691002206 alpha subunit interface [polypeptide binding]; other site 511691002207 TPP binding site [chemical binding]; other site 511691002208 heterodimer interface [polypeptide binding]; other site 511691002209 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 511691002210 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 511691002211 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 511691002212 E3 interaction surface; other site 511691002213 lipoyl attachment site [posttranslational modification]; other site 511691002214 e3 binding domain; Region: E3_binding; pfam02817 511691002215 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 511691002216 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 511691002217 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 511691002218 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 511691002219 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 511691002220 WHG domain; Region: WHG; pfam13305 511691002221 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 511691002222 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511691002223 FeS/SAM binding site; other site 511691002224 HemN C-terminal domain; Region: HemN_C; pfam06969 511691002225 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 511691002226 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 511691002227 active site 511691002228 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 511691002229 active site 2 [active] 511691002230 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 511691002231 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 511691002232 nudix motif; other site 511691002233 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 511691002234 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511691002235 active site 511691002236 motif I; other site 511691002237 motif II; other site 511691002238 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511691002239 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 511691002240 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 511691002241 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 511691002242 Walker A/P-loop; other site 511691002243 ATP binding site [chemical binding]; other site 511691002244 Q-loop/lid; other site 511691002245 ABC transporter signature motif; other site 511691002246 Walker B; other site 511691002247 D-loop; other site 511691002248 H-loop/switch region; other site 511691002249 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 511691002250 FtsX-like permease family; Region: FtsX; pfam02687 511691002251 hypothetical protein; Validated; Region: PRK07121 511691002252 Predicted oxidoreductase [General function prediction only]; Region: COG3573 511691002253 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 511691002254 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511691002255 Predicted flavoprotein [General function prediction only]; Region: COG0431 511691002256 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 511691002257 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 511691002258 CRISPR/Cas system-associated protein Cas9; Region: Csn1; cd09643 511691002259 CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720 511691002260 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 511691002261 CRISPR/Cas system-associated protein Csn2; Region: Csn2; cd09758 511691002262 CRISPR type II-A/NMEMI-associated protein Csn2; Region: cas_Csn2; TIGR01866 511691002263 tetramer interface [polypeptide binding]; other site 511691002264 putative DNA binding site [nucleotide binding]; other site 511691002265 Ca binding site [ion binding]; other site 511691002266 Ca binding site [ion binding]; other site 511691002267 YcfA-like protein; Region: YcfA; pfam07927 511691002268 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 511691002269 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511691002270 non-specific DNA binding site [nucleotide binding]; other site 511691002271 salt bridge; other site 511691002272 sequence-specific DNA binding site [nucleotide binding]; other site 511691002273 Predicted transcriptional regulator [Transcription]; Region: COG2932 511691002274 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 511691002275 Catalytic site [active] 511691002276 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 511691002277 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511691002278 non-specific DNA binding site [nucleotide binding]; other site 511691002279 salt bridge; other site 511691002280 sequence-specific DNA binding site [nucleotide binding]; other site 511691002281 Glucan-binding protein C; Region: GbpC; pfam08363 511691002282 GTP-binding protein LepA; Provisional; Region: PRK05433 511691002283 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 511691002284 G1 box; other site 511691002285 putative GEF interaction site [polypeptide binding]; other site 511691002286 GTP/Mg2+ binding site [chemical binding]; other site 511691002287 Switch I region; other site 511691002288 G2 box; other site 511691002289 G3 box; other site 511691002290 Switch II region; other site 511691002291 G4 box; other site 511691002292 G5 box; other site 511691002293 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 511691002294 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 511691002295 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 511691002296 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 511691002297 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 511691002298 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511691002299 Coenzyme A binding pocket [chemical binding]; other site 511691002300 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 511691002301 active site 511691002302 metal-binding site [ion binding] 511691002303 active site 511691002304 nucleotide-binding site [chemical binding]; other site 511691002305 nucleotide-binding site [chemical binding]; other site 511691002306 DEAD-like helicases superfamily; Region: DEXDc; smart00487 511691002307 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 511691002308 ATP binding site [chemical binding]; other site 511691002309 putative Mg++ binding site [ion binding]; other site 511691002310 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511691002311 nucleotide binding region [chemical binding]; other site 511691002312 ATP-binding site [chemical binding]; other site 511691002313 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 511691002314 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 511691002315 LabA_like proteins; Region: LabA_like; cd06167 511691002316 putative metal binding site [ion binding]; other site 511691002317 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 511691002318 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 511691002319 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 511691002320 Sugar specificity; other site 511691002321 Pyrimidine base specificity; other site 511691002322 ATP-binding site [chemical binding]; other site 511691002323 2-isopropylmalate synthase; Validated; Region: PRK00915 511691002324 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 511691002325 active site 511691002326 catalytic residues [active] 511691002327 metal binding site [ion binding]; metal-binding site 511691002328 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 511691002329 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 511691002330 tartrate dehydrogenase; Region: TTC; TIGR02089 511691002331 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 511691002332 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 511691002333 substrate binding site [chemical binding]; other site 511691002334 ligand binding site [chemical binding]; other site 511691002335 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 511691002336 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 511691002337 substrate binding site [chemical binding]; other site 511691002338 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 511691002339 active site 511691002340 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 511691002341 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 511691002342 Methyltransferase domain; Region: Methyltransf_31; pfam13847 511691002343 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511691002344 S-adenosylmethionine binding site [chemical binding]; other site 511691002345 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 511691002346 catalytic triad [active] 511691002347 active site nucleophile [active] 511691002348 epoxyqueuosine reductase; Region: TIGR00276 511691002349 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 511691002350 PCRF domain; Region: PCRF; pfam03462 511691002351 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 511691002352 RF-1 domain; Region: RF-1; pfam00472 511691002353 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 511691002354 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511691002355 Walker A/P-loop; other site 511691002356 ATP binding site [chemical binding]; other site 511691002357 Q-loop/lid; other site 511691002358 ABC transporter signature motif; other site 511691002359 Walker B; other site 511691002360 D-loop; other site 511691002361 H-loop/switch region; other site 511691002362 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 511691002363 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 511691002364 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 511691002365 acetoin reductase; Validated; Region: PRK08643 511691002366 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 511691002367 NAD binding site [chemical binding]; other site 511691002368 homotetramer interface [polypeptide binding]; other site 511691002369 homodimer interface [polypeptide binding]; other site 511691002370 active site 511691002371 substrate binding site [chemical binding]; other site 511691002372 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 511691002373 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 511691002374 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13540 511691002375 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 511691002376 Walker A/P-loop; other site 511691002377 ATP binding site [chemical binding]; other site 511691002378 Q-loop/lid; other site 511691002379 ABC transporter signature motif; other site 511691002380 Walker B; other site 511691002381 D-loop; other site 511691002382 H-loop/switch region; other site 511691002383 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 511691002384 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK07246 511691002385 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 511691002386 active site 511691002387 catalytic site [active] 511691002388 substrate binding site [chemical binding]; other site 511691002389 DEAD/DEAH box helicase; Region: DEAD; pfam00270 511691002390 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 511691002391 aspartate aminotransferase; Provisional; Region: PRK05764 511691002392 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 511691002393 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511691002394 homodimer interface [polypeptide binding]; other site 511691002395 catalytic residue [active] 511691002396 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 511691002397 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 511691002398 putative dimer interface [polypeptide binding]; other site 511691002399 putative anticodon binding site; other site 511691002400 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 511691002401 homodimer interface [polypeptide binding]; other site 511691002402 motif 1; other site 511691002403 motif 2; other site 511691002404 active site 511691002405 motif 3; other site 511691002406 Glycerol dehydrogenase-like; Region: GlyDH-like2; cd08171 511691002407 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 511691002408 putative active site [active] 511691002409 metal binding site [ion binding]; metal-binding site 511691002410 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 511691002411 homotrimer interaction site [polypeptide binding]; other site 511691002412 putative active site [active] 511691002413 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 511691002414 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 511691002415 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 511691002416 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 511691002417 dimer interface [polypeptide binding]; other site 511691002418 phosphate binding site [ion binding]; other site 511691002419 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 511691002420 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 511691002421 Peptidase family C69; Region: Peptidase_C69; pfam03577 511691002422 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 511691002423 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 511691002424 metal binding site [ion binding]; metal-binding site 511691002425 YodA lipocalin-like domain; Region: YodA; pfam09223 511691002426 Methyltransferase domain; Region: Methyltransf_31; pfam13847 511691002427 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511691002428 S-adenosylmethionine binding site [chemical binding]; other site 511691002429 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 511691002430 Cupin domain; Region: Cupin_2; cl17218 511691002431 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 511691002432 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 511691002433 DHH family; Region: DHH; pfam01368 511691002434 DHHA1 domain; Region: DHHA1; pfam02272 511691002435 putative S-transferase; Provisional; Region: PRK11752 511691002436 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 511691002437 C-terminal domain interface [polypeptide binding]; other site 511691002438 GSH binding site (G-site) [chemical binding]; other site 511691002439 dimer interface [polypeptide binding]; other site 511691002440 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 511691002441 dimer interface [polypeptide binding]; other site 511691002442 N-terminal domain interface [polypeptide binding]; other site 511691002443 active site 511691002444 adenosine deaminase; Provisional; Region: PRK09358 511691002445 active site 511691002446 flavodoxin; Validated; Region: PRK07308 511691002447 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 511691002448 FeS assembly protein SufB; Region: sufB; TIGR01980 511691002449 Uncharacterized conserved protein [Function unknown]; Region: COG0398 511691002450 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 511691002451 hypothetical protein; Provisional; Region: PRK07248 511691002452 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 511691002453 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 511691002454 putative Cl- selectivity filter; other site 511691002455 putative pore gating glutamate residue; other site 511691002456 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 511691002457 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 511691002458 putative Cl- selectivity filter; other site 511691002459 putative pore gating glutamate residue; other site 511691002460 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 511691002461 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 511691002462 DNA binding residues [nucleotide binding] 511691002463 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 511691002464 putative dimer interface [polypeptide binding]; other site 511691002465 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511691002466 putative substrate translocation pore; other site 511691002467 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511691002468 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 511691002469 NADH(P)-binding; Region: NAD_binding_10; pfam13460 511691002470 NAD(P) binding site [chemical binding]; other site 511691002471 active site 511691002472 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 511691002473 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 511691002474 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 511691002475 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 511691002476 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 511691002477 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511691002478 motif II; other site 511691002479 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 511691002480 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511691002481 Mg2+ binding site [ion binding]; other site 511691002482 G-X-G motif; other site 511691002483 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 511691002484 anchoring element; other site 511691002485 dimer interface [polypeptide binding]; other site 511691002486 ATP binding site [chemical binding]; other site 511691002487 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 511691002488 active site 511691002489 putative metal-binding site [ion binding]; other site 511691002490 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 511691002491 septation ring formation regulator EzrA; Provisional; Region: PRK04778 511691002492 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 511691002493 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 511691002494 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511691002495 homodimer interface [polypeptide binding]; other site 511691002496 catalytic residue [active] 511691002497 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 511691002498 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 511691002499 dimer interface [polypeptide binding]; other site 511691002500 motif 1; other site 511691002501 active site 511691002502 motif 2; other site 511691002503 motif 3; other site 511691002504 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 511691002505 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 511691002506 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 511691002507 histidinol dehydrogenase; Region: hisD; TIGR00069 511691002508 NAD binding site [chemical binding]; other site 511691002509 dimerization interface [polypeptide binding]; other site 511691002510 product binding site; other site 511691002511 substrate binding site [chemical binding]; other site 511691002512 zinc binding site [ion binding]; other site 511691002513 catalytic residues [active] 511691002514 phosphoserine phosphatase SerB; Region: serB; TIGR00338 511691002515 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511691002516 motif II; other site 511691002517 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 511691002518 putative active site pocket [active] 511691002519 4-fold oligomerization interface [polypeptide binding]; other site 511691002520 metal binding residues [ion binding]; metal-binding site 511691002521 3-fold/trimer interface [polypeptide binding]; other site 511691002522 Protein of unknown function (DUF2568); Region: DUF2568; pfam10823 511691002523 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 511691002524 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 511691002525 putative active site [active] 511691002526 oxyanion strand; other site 511691002527 catalytic triad [active] 511691002528 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 511691002529 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 511691002530 catalytic residues [active] 511691002531 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 511691002532 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 511691002533 substrate binding site [chemical binding]; other site 511691002534 glutamase interaction surface [polypeptide binding]; other site 511691002535 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 511691002536 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 511691002537 metal binding site [ion binding]; metal-binding site 511691002538 DivIVA protein; Region: DivIVA; pfam05103 511691002539 PemK-like protein; Region: PemK; pfam02452 511691002540 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 511691002541 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 511691002542 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 511691002543 Presynaptic Site I dimer interface [polypeptide binding]; other site 511691002544 catalytic residues [active] 511691002545 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 511691002546 Synaptic Flat tetramer interface [polypeptide binding]; other site 511691002547 Synaptic Site I dimer interface [polypeptide binding]; other site 511691002548 DNA binding site [nucleotide binding] 511691002549 Homeodomain-like domain; Region: HTH_23; pfam13384 511691002550 N-terminal putative catalytic domain of uncharacterized HKD family nucleases fused to putative helicases from the Snf2-like family; Region: PLDc_N_Snf2_like; cd09178 511691002551 PLD-like domain; Region: PLDc_2; pfam13091 511691002552 putative homodimer interface [polypeptide binding]; other site 511691002553 putative active site [active] 511691002554 catalytic site [active] 511691002555 DEAD-like helicases superfamily; Region: DEXDc; smart00487 511691002556 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 511691002557 ATP binding site [chemical binding]; other site 511691002558 putative Mg++ binding site [ion binding]; other site 511691002559 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511691002560 nucleotide binding region [chemical binding]; other site 511691002561 ATP-binding site [chemical binding]; other site 511691002562 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 511691002563 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 511691002564 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511691002565 non-specific DNA binding site [nucleotide binding]; other site 511691002566 salt bridge; other site 511691002567 sequence-specific DNA binding site [nucleotide binding]; other site 511691002568 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 511691002569 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511691002570 motif II; other site 511691002571 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511691002572 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 511691002573 Coenzyme A binding pocket [chemical binding]; other site 511691002574 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 511691002575 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 511691002576 Protein of unknown function (DUF2681); Region: DUF2681; pfam10883 511691002577 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 511691002578 enolase; Provisional; Region: eno; PRK00077 511691002579 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 511691002580 dimer interface [polypeptide binding]; other site 511691002581 metal binding site [ion binding]; metal-binding site 511691002582 substrate binding pocket [chemical binding]; other site 511691002583 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 511691002584 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 511691002585 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 511691002586 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511691002587 active site 511691002588 motif I; other site 511691002589 motif II; other site 511691002590 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 511691002591 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 511691002592 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 511691002593 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 511691002594 GIY-YIG motif/motif A; other site 511691002595 active site 511691002596 catalytic site [active] 511691002597 putative DNA binding site [nucleotide binding]; other site 511691002598 metal binding site [ion binding]; metal-binding site 511691002599 UvrB/uvrC motif; Region: UVR; pfam02151 511691002600 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 511691002601 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 511691002602 dimer interface [polypeptide binding]; other site 511691002603 FMN binding site [chemical binding]; other site 511691002604 dipeptidase PepV; Reviewed; Region: PRK07318 511691002605 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 511691002606 active site 511691002607 metal binding site [ion binding]; metal-binding site 511691002608 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 511691002609 putative uracil binding site [chemical binding]; other site 511691002610 putative active site [active] 511691002611 SnoaL-like domain; Region: SnoaL_2; pfam12680 511691002612 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 511691002613 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 511691002614 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 511691002615 trmE is a tRNA modification GTPase; Region: trmE; cd04164 511691002616 G1 box; other site 511691002617 GTP/Mg2+ binding site [chemical binding]; other site 511691002618 Switch I region; other site 511691002619 G2 box; other site 511691002620 Switch II region; other site 511691002621 G3 box; other site 511691002622 G4 box; other site 511691002623 G5 box; other site 511691002624 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 511691002625 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 511691002626 tetramer (dimer of dimers) interface [polypeptide binding]; other site 511691002627 active site 511691002628 dimer interface [polypeptide binding]; other site 511691002629 phosphopentomutase; Provisional; Region: PRK05362 511691002630 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 511691002631 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 511691002632 purine nucleoside phosphorylase; Provisional; Region: PRK08202 511691002633 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 511691002634 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 511691002635 catalytic triad [active] 511691002636 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 511691002637 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 511691002638 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl09873 511691002639 Transcriptional regulator [Transcription]; Region: LysR; COG0583 511691002640 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511691002641 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 511691002642 dimerization interface [polypeptide binding]; other site 511691002643 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 511691002644 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 511691002645 FAD binding pocket [chemical binding]; other site 511691002646 FAD binding motif [chemical binding]; other site 511691002647 phosphate binding motif [ion binding]; other site 511691002648 beta-alpha-beta structure motif; other site 511691002649 NAD binding pocket [chemical binding]; other site 511691002650 Iron coordination center [ion binding]; other site 511691002651 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 511691002652 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 511691002653 heterodimer interface [polypeptide binding]; other site 511691002654 active site 511691002655 FMN binding site [chemical binding]; other site 511691002656 homodimer interface [polypeptide binding]; other site 511691002657 substrate binding site [chemical binding]; other site 511691002658 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 511691002659 active site 511691002660 dimer interface [polypeptide binding]; other site 511691002661 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511691002662 active site 511691002663 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 511691002664 substrate binding site [chemical binding]; other site 511691002665 Protein of unknown function (DUF419); Region: DUF419; pfam04237 511691002666 amidase; Provisional; Region: PRK06529 511691002667 Amidase; Region: Amidase; cl11426 511691002668 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 511691002669 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 511691002670 substrate binding pocket [chemical binding]; other site 511691002671 membrane-bound complex binding site; other site 511691002672 hinge residues; other site 511691002673 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 511691002674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511691002675 dimer interface [polypeptide binding]; other site 511691002676 conserved gate region; other site 511691002677 putative PBP binding loops; other site 511691002678 ABC-ATPase subunit interface; other site 511691002679 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 511691002680 ligand binding site [chemical binding]; other site 511691002681 active site 511691002682 UGI interface [polypeptide binding]; other site 511691002683 catalytic site [active] 511691002684 dihydroorotase; Validated; Region: pyrC; PRK09357 511691002685 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 511691002686 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 511691002687 active site 511691002688 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408 511691002689 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 511691002690 putative active site [active] 511691002691 putative metal binding site [ion binding]; other site 511691002692 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 511691002693 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 511691002694 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 511691002695 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511691002696 Mg2+ binding site [ion binding]; other site 511691002697 G-X-G motif; other site 511691002698 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 511691002699 anchoring element; other site 511691002700 dimer interface [polypeptide binding]; other site 511691002701 ATP binding site [chemical binding]; other site 511691002702 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 511691002703 active site 511691002704 putative metal-binding site [ion binding]; other site 511691002705 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 511691002706 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 511691002707 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 511691002708 CAP-like domain; other site 511691002709 active site 511691002710 primary dimer interface [polypeptide binding]; other site 511691002711 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 511691002712 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 511691002713 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 511691002714 homodimer interface [polypeptide binding]; other site 511691002715 substrate-cofactor binding pocket; other site 511691002716 catalytic residue [active] 511691002717 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 511691002718 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 511691002719 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 511691002720 RNA binding site [nucleotide binding]; other site 511691002721 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 511691002722 RNA binding site [nucleotide binding]; other site 511691002723 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 511691002724 RNA binding site [nucleotide binding]; other site 511691002725 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 511691002726 RNA binding site [nucleotide binding]; other site 511691002727 Uncharacterized conserved protein [Function unknown]; Region: COG0398 511691002728 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 511691002729 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 511691002730 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 511691002731 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 511691002732 Walker A/P-loop; other site 511691002733 ATP binding site [chemical binding]; other site 511691002734 Q-loop/lid; other site 511691002735 ABC transporter signature motif; other site 511691002736 Walker B; other site 511691002737 D-loop; other site 511691002738 H-loop/switch region; other site 511691002739 Predicted transcriptional regulators [Transcription]; Region: COG1725 511691002740 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 511691002741 DNA-binding site [nucleotide binding]; DNA binding site 511691002742 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279 511691002743 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 511691002744 active site 511691002745 PHP Thumb interface [polypeptide binding]; other site 511691002746 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 511691002747 generic binding surface II; other site 511691002748 generic binding surface I; other site 511691002749 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 511691002750 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 511691002751 active site 511691002752 ADP/pyrophosphate binding site [chemical binding]; other site 511691002753 dimerization interface [polypeptide binding]; other site 511691002754 allosteric effector site; other site 511691002755 fructose-1,6-bisphosphate binding site; other site 511691002756 pyruvate kinase; Provisional; Region: PRK05826 511691002757 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 511691002758 domain interfaces; other site 511691002759 active site 511691002760 Predicted membrane protein [Function unknown]; Region: COG2261 511691002761 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 511691002762 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 511691002763 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 511691002764 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 511691002765 glutaminase active site [active] 511691002766 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 511691002767 dimer interface [polypeptide binding]; other site 511691002768 active site 511691002769 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 511691002770 dimer interface [polypeptide binding]; other site 511691002771 active site 511691002772 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 511691002773 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 511691002774 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 511691002775 active site 511691002776 P-loop; other site 511691002777 phosphorylation site [posttranslational modification] 511691002778 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 511691002779 active site 511691002780 P-loop; other site 511691002781 phosphorylation site [posttranslational modification] 511691002782 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 511691002783 HTH domain; Region: HTH_11; pfam08279 511691002784 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 511691002785 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 511691002786 active site 511691002787 phosphorylation site [posttranslational modification] 511691002788 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 511691002789 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 511691002790 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 511691002791 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 511691002792 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 511691002793 PhnA protein; Region: PhnA; pfam03831 511691002794 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 511691002795 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511691002796 dimer interface [polypeptide binding]; other site 511691002797 conserved gate region; other site 511691002798 ABC-ATPase subunit interface; other site 511691002799 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 511691002800 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511691002801 Walker A/P-loop; other site 511691002802 ATP binding site [chemical binding]; other site 511691002803 Q-loop/lid; other site 511691002804 ABC transporter signature motif; other site 511691002805 Walker B; other site 511691002806 D-loop; other site 511691002807 H-loop/switch region; other site 511691002808 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 511691002809 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 511691002810 substrate binding pocket [chemical binding]; other site 511691002811 membrane-bound complex binding site; other site 511691002812 hinge residues; other site 511691002813 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 511691002814 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 511691002815 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 511691002816 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 511691002817 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 511691002818 Part of AAA domain; Region: AAA_19; pfam13245 511691002819 Family description; Region: UvrD_C_2; pfam13538 511691002820 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 511691002821 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 511691002822 homodimer interface [polypeptide binding]; other site 511691002823 substrate-cofactor binding pocket; other site 511691002824 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511691002825 catalytic residue [active] 511691002826 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 511691002827 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 511691002828 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 511691002829 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 511691002830 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 511691002831 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 511691002832 catalytic residues [active] 511691002833 IS199 511691002834 HTH-like domain; Region: HTH_21; pfam13276 511691002835 Integrase core domain; Region: rve; pfam00665 511691002836 Integrase core domain; Region: rve_3; pfam13683 511691002837 ISSdy1 511691002838 Transposase; Region: HTH_Tnp_1; pfam01527 511691002839 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 511691002840 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 511691002841 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 511691002842 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 511691002843 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 511691002844 Walker A/P-loop; other site 511691002845 ATP binding site [chemical binding]; other site 511691002846 Q-loop/lid; other site 511691002847 ABC transporter signature motif; other site 511691002848 Walker B; other site 511691002849 D-loop; other site 511691002850 H-loop/switch region; other site 511691002851 FtsX-like permease family; Region: FtsX; pfam02687 511691002852 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 511691002853 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 511691002854 FtsX-like permease family; Region: FtsX; pfam02687 511691002855 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 511691002856 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 511691002857 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 511691002858 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 511691002859 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511691002860 Walker A/P-loop; other site 511691002861 ATP binding site [chemical binding]; other site 511691002862 Q-loop/lid; other site 511691002863 ABC transporter signature motif; other site 511691002864 Walker B; other site 511691002865 D-loop; other site 511691002866 H-loop/switch region; other site 511691002867 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 511691002868 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 511691002869 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511691002870 Walker A/P-loop; other site 511691002871 ATP binding site [chemical binding]; other site 511691002872 Q-loop/lid; other site 511691002873 ABC transporter signature motif; other site 511691002874 Walker B; other site 511691002875 D-loop; other site 511691002876 H-loop/switch region; other site 511691002877 Abortive infection C-terminus; Region: Abi_C; pfam14355 511691002878 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 511691002879 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 511691002880 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 511691002881 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511691002882 Coenzyme A binding pocket [chemical binding]; other site 511691002883 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 511691002884 Uncharacterized conserved protein [Function unknown]; Region: COG2461 511691002885 Family of unknown function (DUF438); Region: DUF438; pfam04282 511691002886 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 511691002887 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 511691002888 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 511691002889 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 511691002890 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 511691002891 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 511691002892 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511691002893 ABC transporter signature motif; other site 511691002894 Walker B; other site 511691002895 D-loop; other site 511691002896 H-loop/switch region; other site 511691002897 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511691002898 Walker A/P-loop; other site 511691002899 ATP binding site [chemical binding]; other site 511691002900 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 511691002901 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511691002902 active site 511691002903 phosphorylation site [posttranslational modification] 511691002904 intermolecular recognition site; other site 511691002905 dimerization interface [polypeptide binding]; other site 511691002906 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 511691002907 DNA binding site [nucleotide binding] 511691002908 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 511691002909 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 511691002910 dimer interface [polypeptide binding]; other site 511691002911 phosphorylation site [posttranslational modification] 511691002912 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511691002913 ATP binding site [chemical binding]; other site 511691002914 Mg2+ binding site [ion binding]; other site 511691002915 G-X-G motif; other site 511691002916 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 511691002917 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 511691002918 RNA binding site [nucleotide binding]; other site 511691002919 active site 511691002920 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 511691002921 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 511691002922 active site 511691002923 Riboflavin kinase; Region: Flavokinase; smart00904 511691002924 ArsC family; Region: ArsC; pfam03960 511691002925 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 511691002926 putative catalytic residues [active] 511691002927 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 511691002928 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 511691002929 active site 511691002930 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 511691002931 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511691002932 S-adenosylmethionine binding site [chemical binding]; other site 511691002933 Uncharacterized conserved protein [Function unknown]; Region: COG3270 511691002934 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 511691002935 PBP superfamily domain; Region: PBP_like_2; cl17296 511691002936 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 511691002937 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511691002938 dimer interface [polypeptide binding]; other site 511691002939 conserved gate region; other site 511691002940 putative PBP binding loops; other site 511691002941 ABC-ATPase subunit interface; other site 511691002942 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 511691002943 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511691002944 dimer interface [polypeptide binding]; other site 511691002945 conserved gate region; other site 511691002946 putative PBP binding loops; other site 511691002947 ABC-ATPase subunit interface; other site 511691002948 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 511691002949 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 511691002950 Walker A/P-loop; other site 511691002951 ATP binding site [chemical binding]; other site 511691002952 Q-loop/lid; other site 511691002953 ABC transporter signature motif; other site 511691002954 Walker B; other site 511691002955 D-loop; other site 511691002956 H-loop/switch region; other site 511691002957 phosphate transporter ATP-binding protein; Provisional; Region: PRK14239 511691002958 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 511691002959 Walker A/P-loop; other site 511691002960 ATP binding site [chemical binding]; other site 511691002961 Q-loop/lid; other site 511691002962 ABC transporter signature motif; other site 511691002963 Walker B; other site 511691002964 D-loop; other site 511691002965 H-loop/switch region; other site 511691002966 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 511691002967 PhoU domain; Region: PhoU; pfam01895 511691002968 PhoU domain; Region: PhoU; pfam01895 511691002969 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 511691002970 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 511691002971 Zn binding site [ion binding]; other site 511691002972 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 511691002973 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511691002974 active site 511691002975 phosphorylation site [posttranslational modification] 511691002976 intermolecular recognition site; other site 511691002977 dimerization interface [polypeptide binding]; other site 511691002978 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 511691002979 DNA binding site [nucleotide binding] 511691002980 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 511691002981 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 511691002982 dimer interface [polypeptide binding]; other site 511691002983 phosphorylation site [posttranslational modification] 511691002984 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511691002985 ATP binding site [chemical binding]; other site 511691002986 Mg2+ binding site [ion binding]; other site 511691002987 G-X-G motif; other site 511691002988 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 511691002989 pantothenate kinase; Provisional; Region: PRK05439 511691002990 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 511691002991 ATP-binding site [chemical binding]; other site 511691002992 CoA-binding site [chemical binding]; other site 511691002993 Mg2+-binding site [ion binding]; other site 511691002994 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 511691002995 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511691002996 S-adenosylmethionine binding site [chemical binding]; other site 511691002997 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 511691002998 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 511691002999 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 511691003000 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 511691003001 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 511691003002 intersubunit interface [polypeptide binding]; other site 511691003003 active site 511691003004 catalytic residue [active] 511691003005 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 511691003006 active site 511691003007 catalytic motif [active] 511691003008 Zn binding site [ion binding]; other site 511691003009 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 511691003010 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 511691003011 ligand binding site [chemical binding]; other site 511691003012 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 511691003013 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 511691003014 Walker A/P-loop; other site 511691003015 ATP binding site [chemical binding]; other site 511691003016 Q-loop/lid; other site 511691003017 ABC transporter signature motif; other site 511691003018 Walker B; other site 511691003019 D-loop; other site 511691003020 H-loop/switch region; other site 511691003021 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 511691003022 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 511691003023 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 511691003024 TM-ABC transporter signature motif; other site 511691003025 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 511691003026 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 511691003027 TM-ABC transporter signature motif; other site 511691003028 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 511691003029 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 511691003030 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 511691003031 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 511691003032 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 511691003033 tetramer (dimer of dimers) interface [polypeptide binding]; other site 511691003034 NAD binding site [chemical binding]; other site 511691003035 dimer interface [polypeptide binding]; other site 511691003036 substrate binding site [chemical binding]; other site 511691003037 DNA gyrase subunit A; Validated; Region: PRK05560 511691003038 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 511691003039 CAP-like domain; other site 511691003040 active site 511691003041 primary dimer interface [polypeptide binding]; other site 511691003042 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 511691003043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 511691003044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 511691003045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 511691003046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 511691003047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 511691003048 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 511691003049 active site 511691003050 catalytic site [active] 511691003051 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 511691003052 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 511691003053 putative metal binding site [ion binding]; other site 511691003054 Predicted secreted protein [Function unknown]; Region: COG4086 511691003055 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 511691003056 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 511691003057 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511691003058 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 511691003059 active site 511691003060 motif I; other site 511691003061 motif II; other site 511691003062 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 511691003063 NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841 511691003064 active site 511691003065 catalytic triad [active] 511691003066 oxyanion hole [active] 511691003067 Histidine phosphatase superfamily (branch 1); Region: His_Phos_1; pfam00300 511691003068 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 511691003069 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 511691003070 catalytic core [active] 511691003071 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 511691003072 catalytic core [active] 511691003073 6-phospho-beta-glucosidase; Reviewed; Region: arb; PRK09593 511691003074 beta-galactosidase; Region: BGL; TIGR03356 511691003075 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 511691003076 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 511691003077 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 511691003078 putative NAD(P) binding site [chemical binding]; other site 511691003079 Transcriptional regulators [Transcription]; Region: MarR; COG1846 511691003080 MarR family; Region: MarR_2; pfam12802 511691003081 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 511691003082 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511691003083 Walker A/P-loop; other site 511691003084 ATP binding site [chemical binding]; other site 511691003085 Q-loop/lid; other site 511691003086 ABC transporter signature motif; other site 511691003087 Walker B; other site 511691003088 D-loop; other site 511691003089 H-loop/switch region; other site 511691003090 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511691003091 dimer interface [polypeptide binding]; other site 511691003092 conserved gate region; other site 511691003093 ABC-ATPase subunit interface; other site 511691003094 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 511691003095 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 511691003096 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 511691003097 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 511691003098 Walker A/P-loop; other site 511691003099 ATP binding site [chemical binding]; other site 511691003100 Q-loop/lid; other site 511691003101 ABC transporter signature motif; other site 511691003102 Walker B; other site 511691003103 D-loop; other site 511691003104 H-loop/switch region; other site 511691003105 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 511691003106 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 511691003107 FtsX-like permease family; Region: FtsX; pfam02687 511691003108 putative cross-wall-targeting lipoprotein signal; Region: strep_RK_lipo; TIGR03726 511691003109 Predicted flavoprotein [General function prediction only]; Region: COG0431 511691003110 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 511691003111 PAS domain; Region: PAS_10; pfam13596 511691003112 Predicted flavoprotein [General function prediction only]; Region: COG0431 511691003113 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 511691003114 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 511691003115 ApbE family; Region: ApbE; pfam02424 511691003116 4-oxalocrotonate tautomerase; Provisional; Region: PRK02289 511691003117 active site 1 [active] 511691003118 dimer interface [polypeptide binding]; other site 511691003119 hexamer interface [polypeptide binding]; other site 511691003120 active site 2 [active] 511691003121 thymidine kinase; Provisional; Region: PRK04296 511691003122 peptide chain release factor 1; Validated; Region: prfA; PRK00591 511691003123 This domain is found in peptide chain release factors; Region: PCRF; smart00937 511691003124 RF-1 domain; Region: RF-1; pfam00472 511691003125 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 511691003126 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511691003127 S-adenosylmethionine binding site [chemical binding]; other site 511691003128 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 511691003129 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 511691003130 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 511691003131 dimer interface [polypeptide binding]; other site 511691003132 active site 511691003133 glycine-pyridoxal phosphate binding site [chemical binding]; other site 511691003134 folate binding site [chemical binding]; other site 511691003135 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 511691003136 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 511691003137 N-acetyl-D-glucosamine binding site [chemical binding]; other site 511691003138 catalytic residue [active] 511691003139 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 511691003140 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 511691003141 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511691003142 Walker A/P-loop; other site 511691003143 ATP binding site [chemical binding]; other site 511691003144 Q-loop/lid; other site 511691003145 ABC transporter signature motif; other site 511691003146 Walker B; other site 511691003147 D-loop; other site 511691003148 H-loop/switch region; other site 511691003149 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 511691003150 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 511691003151 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 511691003152 Walker A/P-loop; other site 511691003153 ATP binding site [chemical binding]; other site 511691003154 Q-loop/lid; other site 511691003155 ABC transporter signature motif; other site 511691003156 Walker B; other site 511691003157 D-loop; other site 511691003158 H-loop/switch region; other site 511691003159 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 511691003160 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 511691003161 active site 511691003162 substrate binding site [chemical binding]; other site 511691003163 metal binding site [ion binding]; metal-binding site 511691003164 Predicted membrane protein [Function unknown]; Region: COG4684 511691003165 phosphopantothenoylcysteine decarboxylase, streptococcal; Region: coaC_strep; TIGR02113 511691003166 Flavoprotein; Region: Flavoprotein; pfam02441 511691003167 phosphopantothenate--cysteine ligase; Validated; Region: PRK06732 511691003168 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 511691003169 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 511691003170 Potassium binding sites [ion binding]; other site 511691003171 Cesium cation binding sites [ion binding]; other site 511691003172 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 511691003173 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 511691003174 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 511691003175 LytTr DNA-binding domain; Region: LytTR; pfam04397 511691003176 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 511691003177 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 511691003178 Walker A/P-loop; other site 511691003179 ATP binding site [chemical binding]; other site 511691003180 Q-loop/lid; other site 511691003181 ABC transporter signature motif; other site 511691003182 Walker B; other site 511691003183 D-loop; other site 511691003184 H-loop/switch region; other site 511691003185 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 511691003186 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 511691003187 GMP synthase; Reviewed; Region: guaA; PRK00074 511691003188 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 511691003189 AMP/PPi binding site [chemical binding]; other site 511691003190 candidate oxyanion hole; other site 511691003191 catalytic triad [active] 511691003192 potential glutamine specificity residues [chemical binding]; other site 511691003193 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 511691003194 ATP Binding subdomain [chemical binding]; other site 511691003195 Dimerization subdomain; other site 511691003196 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 511691003197 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 511691003198 DNA-binding site [nucleotide binding]; DNA binding site 511691003199 UTRA domain; Region: UTRA; pfam07702 511691003200 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 511691003201 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 511691003202 DNA-binding site [nucleotide binding]; DNA binding site 511691003203 TrkA-C domain; Region: TrkA_C; pfam02080 511691003204 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 511691003205 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 511691003206 Walker A/P-loop; other site 511691003207 ATP binding site [chemical binding]; other site 511691003208 Q-loop/lid; other site 511691003209 ABC transporter signature motif; other site 511691003210 Walker B; other site 511691003211 D-loop; other site 511691003212 H-loop/switch region; other site 511691003213 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 511691003214 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511691003215 dimer interface [polypeptide binding]; other site 511691003216 conserved gate region; other site 511691003217 putative PBP binding loops; other site 511691003218 ABC-ATPase subunit interface; other site 511691003219 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 511691003220 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 511691003221 putative DNA-binding protein; Validated; Region: PRK00118 511691003222 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 511691003223 signal recognition particle protein; Provisional; Region: PRK10867 511691003224 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 511691003225 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 511691003226 P loop; other site 511691003227 GTP binding site [chemical binding]; other site 511691003228 Signal peptide binding domain; Region: SRP_SPB; pfam02978 511691003229 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 511691003230 hypothetical protein; Reviewed; Region: PRK00024 511691003231 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 511691003232 MPN+ (JAMM) motif; other site 511691003233 Zinc-binding site [ion binding]; other site 511691003234 Peptidase C26; Region: Peptidase_C26; pfam07722 511691003235 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 511691003236 catalytic triad [active] 511691003237 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 511691003238 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 511691003239 CoA binding domain; Region: CoA_binding; pfam02629 511691003240 IS861 fragment 511691003241 Putative amino acid metabolism; Region: DUF1831; pfam08866 511691003242 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 511691003243 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 511691003244 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 511691003245 catalytic residue [active] 511691003246 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458 511691003247 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 511691003248 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511691003249 active site 511691003250 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 511691003251 putative active site [active] 511691003252 putative metal binding residues [ion binding]; other site 511691003253 signature motif; other site 511691003254 putative triphosphate binding site [ion binding]; other site 511691003255 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 511691003256 synthetase active site [active] 511691003257 NTP binding site [chemical binding]; other site 511691003258 metal binding site [ion binding]; metal-binding site 511691003259 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 511691003260 ATP-NAD kinase; Region: NAD_kinase; pfam01513 511691003261 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 511691003262 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 511691003263 active site 511691003264 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 511691003265 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 511691003266 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 511691003267 Walker A/P-loop; other site 511691003268 ATP binding site [chemical binding]; other site 511691003269 Q-loop/lid; other site 511691003270 ABC transporter signature motif; other site 511691003271 Walker B; other site 511691003272 D-loop; other site 511691003273 H-loop/switch region; other site 511691003274 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 511691003275 malonic semialdehyde reductase; Provisional; Region: PRK10538 511691003276 putative NAD(P) binding site [chemical binding]; other site 511691003277 homotetramer interface [polypeptide binding]; other site 511691003278 homodimer interface [polypeptide binding]; other site 511691003279 active site 511691003280 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 511691003281 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 511691003282 Ligand binding site; other site 511691003283 metal-binding site 511691003284 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 511691003285 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511691003286 active site 511691003287 phosphorylation site [posttranslational modification] 511691003288 intermolecular recognition site; other site 511691003289 dimerization interface [polypeptide binding]; other site 511691003290 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 511691003291 DNA binding site [nucleotide binding] 511691003292 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 511691003293 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 511691003294 dimer interface [polypeptide binding]; other site 511691003295 phosphorylation site [posttranslational modification] 511691003296 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511691003297 ATP binding site [chemical binding]; other site 511691003298 Mg2+ binding site [ion binding]; other site 511691003299 G-X-G motif; other site 511691003300 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 511691003301 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 511691003302 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511691003303 Walker A/P-loop; other site 511691003304 ATP binding site [chemical binding]; other site 511691003305 Q-loop/lid; other site 511691003306 ABC transporter signature motif; other site 511691003307 Walker B; other site 511691003308 D-loop; other site 511691003309 H-loop/switch region; other site 511691003310 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 511691003311 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 511691003312 active site 511691003313 DNA binding site [nucleotide binding] 511691003314 Int/Topo IB signature motif; other site 511691003315 ISScr1 511691003316 IS861 fragment 511691003317 oxaloacetate decarboxylase; Provisional; Region: PRK12331 511691003318 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 511691003319 active site 511691003320 catalytic residues [active] 511691003321 metal binding site [ion binding]; metal-binding site 511691003322 homodimer binding site [polypeptide binding]; other site 511691003323 2'-(5''-triphosphoribosyl)-3'- dephospho-CoA:apo-citrate lyase; Reviewed; Region: citX; PRK01392 511691003324 Citrate lyase, alpha subunit (CitF); Region: CitF; pfam04223 511691003325 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 511691003326 citrate lyase subunit gamma; Provisional; Region: PRK13253 511691003327 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; pfam04277 511691003328 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; pfam03977 511691003329 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549 511691003330 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 511691003331 carboxyltransferase (CT) interaction site; other site 511691003332 biotinylation site [posttranslational modification]; other site 511691003333 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 511691003334 Citrate transporter; Region: CitMHS; pfam03600 511691003335 Transcriptional regulators [Transcription]; Region: GntR; COG1802 511691003336 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 511691003337 DNA-binding site [nucleotide binding]; DNA binding site 511691003338 FCD domain; Region: FCD; pfam07729 511691003339 triphosphoribosyl-dephospho-CoA synthase CitG; Region: citrate_citG; TIGR03125 511691003340 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 511691003341 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 511691003342 putative active site [active] 511691003343 (T/H)XGH motif; other site 511691003344 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 511691003345 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511691003346 ATP binding site [chemical binding]; other site 511691003347 Mg2+ binding site [ion binding]; other site 511691003348 G-X-G motif; other site 511691003349 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 511691003350 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511691003351 active site 511691003352 phosphorylation site [posttranslational modification] 511691003353 intermolecular recognition site; other site 511691003354 dimerization interface [polypeptide binding]; other site 511691003355 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 511691003356 DNA binding site [nucleotide binding] 511691003357 FtsX-like permease family; Region: FtsX; pfam02687 511691003358 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 511691003359 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 511691003360 Walker A/P-loop; other site 511691003361 ATP binding site [chemical binding]; other site 511691003362 Q-loop/lid; other site 511691003363 ABC transporter signature motif; other site 511691003364 Walker B; other site 511691003365 D-loop; other site 511691003366 H-loop/switch region; other site 511691003367 Glycosyl hydrolase family 70; Region: Glyco_hydro_70; pfam02324 511691003368 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 511691003369 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 511691003370 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 511691003371 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 511691003372 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 511691003373 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 511691003374 Glycosyl hydrolase family 70; Region: Glyco_hydro_70; pfam02324 511691003375 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 511691003376 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 511691003377 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 511691003378 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 511691003379 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 511691003380 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 511691003381 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 511691003382 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 511691003383 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 511691003384 Glucose inhibited division protein A; Region: GIDA; pfam01134 511691003385 DNA topoisomerase I; Validated; Region: PRK05582 511691003386 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 511691003387 active site 511691003388 interdomain interaction site; other site 511691003389 putative metal-binding site [ion binding]; other site 511691003390 nucleotide binding site [chemical binding]; other site 511691003391 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 511691003392 domain I; other site 511691003393 DNA binding groove [nucleotide binding] 511691003394 phosphate binding site [ion binding]; other site 511691003395 domain II; other site 511691003396 domain III; other site 511691003397 nucleotide binding site [chemical binding]; other site 511691003398 catalytic site [active] 511691003399 domain IV; other site 511691003400 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 511691003401 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 511691003402 DNA protecting protein DprA; Region: dprA; TIGR00732 511691003403 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 511691003404 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 511691003405 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 511691003406 putative ligand binding residues [chemical binding]; other site 511691003407 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 511691003408 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 511691003409 Walker A/P-loop; other site 511691003410 ATP binding site [chemical binding]; other site 511691003411 Q-loop/lid; other site 511691003412 ABC transporter signature motif; other site 511691003413 Walker B; other site 511691003414 D-loop; other site 511691003415 H-loop/switch region; other site 511691003416 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 511691003417 ABC-ATPase subunit interface; other site 511691003418 dimer interface [polypeptide binding]; other site 511691003419 putative PBP binding regions; other site 511691003420 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 511691003421 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 511691003422 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 511691003423 ABC-ATPase subunit interface; other site 511691003424 dimer interface [polypeptide binding]; other site 511691003425 putative PBP binding regions; other site 511691003426 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 511691003427 RNA/DNA hybrid binding site [nucleotide binding]; other site 511691003428 active site 511691003429 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 511691003430 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 511691003431 GTP/Mg2+ binding site [chemical binding]; other site 511691003432 G4 box; other site 511691003433 G5 box; other site 511691003434 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 511691003435 G1 box; other site 511691003436 G1 box; other site 511691003437 GTP/Mg2+ binding site [chemical binding]; other site 511691003438 Switch I region; other site 511691003439 G2 box; other site 511691003440 G2 box; other site 511691003441 G3 box; other site 511691003442 G3 box; other site 511691003443 Switch II region; other site 511691003444 Switch II region; other site 511691003445 G5 box; other site 511691003446 ATP cone domain; Region: ATP-cone; pfam03477 511691003447 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 511691003448 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 511691003449 dimer interface [polypeptide binding]; other site 511691003450 active site 511691003451 catalytic residue [active] 511691003452 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 511691003453 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 511691003454 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 511691003455 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 511691003456 Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154 511691003457 putative active site [active] 511691003458 catalytic site [active] 511691003459 Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160 511691003460 putative active site [active] 511691003461 catalytic site [active] 511691003462 Collagen binding domain; Region: Collagen_bind; pfam05737 511691003463 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 511691003464 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511691003465 non-specific DNA binding site [nucleotide binding]; other site 511691003466 salt bridge; other site 511691003467 sequence-specific DNA binding site [nucleotide binding]; other site 511691003468 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 511691003469 beta-galactosidase; Region: BGL; TIGR03356 511691003470 CHAP domain; Region: CHAP; pfam05257 511691003471 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 511691003472 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 511691003473 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511691003474 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511691003475 Predicted peptidase [General function prediction only]; Region: COG4099 511691003476 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 511691003477 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 511691003478 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 511691003479 active site turn [active] 511691003480 phosphorylation site [posttranslational modification] 511691003481 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 511691003482 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 511691003483 HPr interaction site; other site 511691003484 glycerol kinase (GK) interaction site [polypeptide binding]; other site 511691003485 active site 511691003486 phosphorylation site [posttranslational modification] 511691003487 transcriptional antiterminator BglG; Provisional; Region: PRK09772 511691003488 CAT RNA binding domain; Region: CAT_RBD; smart01061 511691003489 PRD domain; Region: PRD; pfam00874 511691003490 PRD domain; Region: PRD; pfam00874 511691003491 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 511691003492 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 511691003493 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 511691003494 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511691003495 dimer interface [polypeptide binding]; other site 511691003496 conserved gate region; other site 511691003497 putative PBP binding loops; other site 511691003498 ABC-ATPase subunit interface; other site 511691003499 sulfate transport protein; Provisional; Region: cysT; CHL00187 511691003500 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511691003501 dimer interface [polypeptide binding]; other site 511691003502 conserved gate region; other site 511691003503 putative PBP binding loops; other site 511691003504 ABC-ATPase subunit interface; other site 511691003505 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 511691003506 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 511691003507 Walker A/P-loop; other site 511691003508 ATP binding site [chemical binding]; other site 511691003509 Q-loop/lid; other site 511691003510 ABC transporter signature motif; other site 511691003511 Walker B; other site 511691003512 D-loop; other site 511691003513 H-loop/switch region; other site 511691003514 TOBE domain; Region: TOBE_2; pfam08402 511691003515 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 511691003516 FAD binding domain; Region: FAD_binding_4; pfam01565 511691003517 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 511691003518 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 511691003519 catalytic center binding site [active] 511691003520 ATP binding site [chemical binding]; other site 511691003521 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 511691003522 homooctamer interface [polypeptide binding]; other site 511691003523 active site 511691003524 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 511691003525 dihydropteroate synthase; Region: DHPS; TIGR01496 511691003526 substrate binding pocket [chemical binding]; other site 511691003527 dimer interface [polypeptide binding]; other site 511691003528 inhibitor binding site; inhibition site 511691003529 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 511691003530 homodecamer interface [polypeptide binding]; other site 511691003531 GTP cyclohydrolase I; Provisional; Region: PLN03044 511691003532 active site 511691003533 putative catalytic site residues [active] 511691003534 zinc binding site [ion binding]; other site 511691003535 GTP-CH-I/GFRP interaction surface; other site 511691003536 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 511691003537 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 511691003538 homoserine kinase; Provisional; Region: PRK01212 511691003539 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 511691003540 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 511691003541 homoserine dehydrogenase; Provisional; Region: PRK06349 511691003542 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 511691003543 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 511691003544 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 511691003545 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 511691003546 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 511691003547 putative active site [active] 511691003548 putative metal binding site [ion binding]; other site 511691003549 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 511691003550 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 511691003551 active site 511691003552 Uncharacterized conserved protein [Function unknown]; Region: COG2128 511691003553 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 511691003554 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 511691003555 Int/Topo IB signature motif; other site 511691003556 Domain of unknown function (DUF3173); Region: DUF3173; pfam11372 511691003557 Plasmid replication protein; Region: Rep_2; pfam01719 511691003558 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 511691003559 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 511691003560 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 511691003561 active site 511691003562 NTP binding site [chemical binding]; other site 511691003563 metal binding triad [ion binding]; metal-binding site 511691003564 Predicted helicase [General function prediction only]; Region: COG4889 511691003565 Restriction endonuclease; Region: Mrr_cat_2; pfam13156 511691003566 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 511691003567 nucleotide binding region [chemical binding]; other site 511691003568 helicase superfamily c-terminal domain; Region: HELICc; smart00490 511691003569 ATP-binding site [chemical binding]; other site 511691003570 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 511691003571 core dimer interface [polypeptide binding]; other site 511691003572 L10 interface [polypeptide binding]; other site 511691003573 L11 interface [polypeptide binding]; other site 511691003574 putative EF-Tu interaction site [polypeptide binding]; other site 511691003575 putative EF-G interaction site [polypeptide binding]; other site 511691003576 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 511691003577 23S rRNA interface [nucleotide binding]; other site 511691003578 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 511691003579 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511691003580 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 511691003581 Walker A motif; other site 511691003582 ATP binding site [chemical binding]; other site 511691003583 Walker B motif; other site 511691003584 arginine finger; other site 511691003585 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511691003586 Walker A motif; other site 511691003587 ATP binding site [chemical binding]; other site 511691003588 Walker B motif; other site 511691003589 arginine finger; other site 511691003590 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 511691003591 Predicted membrane protein [Function unknown]; Region: COG4720 511691003592 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 511691003593 dimer interface [polypeptide binding]; other site 511691003594 pyridoxal binding site [chemical binding]; other site 511691003595 ATP binding site [chemical binding]; other site 511691003596 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 511691003597 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 511691003598 DNA-binding site [nucleotide binding]; DNA binding site 511691003599 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 511691003600 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511691003601 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 511691003602 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 511691003603 S-methylmethionine transporter; Provisional; Region: PRK11387 511691003604 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 511691003605 G1 box; other site 511691003606 GTP/Mg2+ binding site [chemical binding]; other site 511691003607 Switch I region; other site 511691003608 G2 box; other site 511691003609 G3 box; other site 511691003610 Switch II region; other site 511691003611 G4 box; other site 511691003612 G5 box; other site 511691003613 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 511691003614 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 511691003615 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511691003616 Walker A motif; other site 511691003617 ATP binding site [chemical binding]; other site 511691003618 Walker B motif; other site 511691003619 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 511691003620 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 511691003621 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 511691003622 folate binding site [chemical binding]; other site 511691003623 NADP+ binding site [chemical binding]; other site 511691003624 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 511691003625 thymidylate synthase; Reviewed; Region: thyA; PRK01827 511691003626 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 511691003627 dimerization interface [polypeptide binding]; other site 511691003628 active site 511691003629 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 511691003630 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 511691003631 dimer interface [polypeptide binding]; other site 511691003632 active site 511691003633 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 511691003634 homodimer interface [polypeptide binding]; other site 511691003635 catalytic residues [active] 511691003636 NAD binding site [chemical binding]; other site 511691003637 substrate binding pocket [chemical binding]; other site 511691003638 flexible flap; other site 511691003639 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 511691003640 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 511691003641 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 511691003642 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 511691003643 ISSdy1 (IS200S) 511691003644 Transposase IS200 like; Region: Y1_Tnp; pfam01797 511691003645 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 511691003646 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 511691003647 homotetramer interface [polypeptide binding]; other site 511691003648 FMN binding site [chemical binding]; other site 511691003649 homodimer contacts [polypeptide binding]; other site 511691003650 putative active site [active] 511691003651 putative substrate binding site [chemical binding]; other site 511691003652 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 511691003653 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 511691003654 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 511691003655 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 511691003656 diphosphomevalonate decarboxylase; Region: PLN02407 511691003657 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 511691003658 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 511691003659 Walker A/P-loop; other site 511691003660 ATP binding site [chemical binding]; other site 511691003661 Q-loop/lid; other site 511691003662 ABC transporter signature motif; other site 511691003663 Walker B; other site 511691003664 D-loop; other site 511691003665 H-loop/switch region; other site 511691003666 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 511691003667 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511691003668 dimer interface [polypeptide binding]; other site 511691003669 conserved gate region; other site 511691003670 putative PBP binding loops; other site 511691003671 ABC-ATPase subunit interface; other site 511691003672 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511691003673 dimer interface [polypeptide binding]; other site 511691003674 conserved gate region; other site 511691003675 putative PBP binding loops; other site 511691003676 ABC-ATPase subunit interface; other site 511691003677 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 511691003678 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 511691003679 substrate binding pocket [chemical binding]; other site 511691003680 membrane-bound complex binding site; other site 511691003681 hinge residues; other site 511691003682 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 511691003683 Transcriptional regulator [Transcription]; Region: LysR; COG0583 511691003684 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511691003685 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 511691003686 dimerization interface [polypeptide binding]; other site 511691003687 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 511691003688 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 511691003689 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 511691003690 dimer interface [polypeptide binding]; other site 511691003691 phosphorylation site [posttranslational modification] 511691003692 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511691003693 ATP binding site [chemical binding]; other site 511691003694 Mg2+ binding site [ion binding]; other site 511691003695 G-X-G motif; other site 511691003696 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 511691003697 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511691003698 active site 511691003699 phosphorylation site [posttranslational modification] 511691003700 intermolecular recognition site; other site 511691003701 dimerization interface [polypeptide binding]; other site 511691003702 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 511691003703 DNA binding site [nucleotide binding] 511691003704 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 511691003705 synthetase active site [active] 511691003706 NTP binding site [chemical binding]; other site 511691003707 metal binding site [ion binding]; metal-binding site 511691003708 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 511691003709 dimer interface [polypeptide binding]; other site 511691003710 catalytic triad [active] 511691003711 peroxidatic and resolving cysteines [active] 511691003712 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 511691003713 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 511691003714 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 511691003715 Walker A/P-loop; other site 511691003716 ATP binding site [chemical binding]; other site 511691003717 Q-loop/lid; other site 511691003718 ABC transporter signature motif; other site 511691003719 Walker B; other site 511691003720 D-loop; other site 511691003721 H-loop/switch region; other site 511691003722 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 511691003723 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 511691003724 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511691003725 Walker A/P-loop; other site 511691003726 ATP binding site [chemical binding]; other site 511691003727 Q-loop/lid; other site 511691003728 ABC transporter signature motif; other site 511691003729 Walker B; other site 511691003730 D-loop; other site 511691003731 H-loop/switch region; other site 511691003732 Transcriptional regulators [Transcription]; Region: MarR; COG1846 511691003733 MarR family; Region: MarR_2; pfam12802 511691003734 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 511691003735 Ligand Binding Site [chemical binding]; other site 511691003736 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 511691003737 active site 511691003738 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 511691003739 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 511691003740 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 511691003741 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 511691003742 glutamate dehydrogenase; Provisional; Region: PRK09414 511691003743 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 511691003744 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 511691003745 NAD(P) binding site [chemical binding]; other site 511691003746 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 511691003747 Glycosyl hydrolase family 70; Region: Glyco_hydro_70; pfam02324 511691003748 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 511691003749 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 511691003750 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 511691003751 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 511691003752 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 511691003753 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 511691003754 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 511691003755 Membrane transport protein; Region: Mem_trans; cl09117 511691003756 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 511691003757 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 511691003758 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 511691003759 Walker A/P-loop; other site 511691003760 ATP binding site [chemical binding]; other site 511691003761 Q-loop/lid; other site 511691003762 ABC transporter signature motif; other site 511691003763 Walker B; other site 511691003764 D-loop; other site 511691003765 H-loop/switch region; other site 511691003766 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 511691003767 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 511691003768 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511691003769 Walker A/P-loop; other site 511691003770 ATP binding site [chemical binding]; other site 511691003771 Q-loop/lid; other site 511691003772 ABC transporter signature motif; other site 511691003773 Walker B; other site 511691003774 D-loop; other site 511691003775 H-loop/switch region; other site 511691003776 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 511691003777 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511691003778 Walker A/P-loop; other site 511691003779 ATP binding site [chemical binding]; other site 511691003780 Q-loop/lid; other site 511691003781 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 511691003782 ABC transporter; Region: ABC_tran_2; pfam12848 511691003783 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 511691003784 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 511691003785 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 511691003786 active site 511691003787 NTP binding site [chemical binding]; other site 511691003788 metal binding triad [ion binding]; metal-binding site 511691003789 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 511691003790 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 511691003791 dihydrodipicolinate reductase; Provisional; Region: PRK00048 511691003792 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 511691003793 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 511691003794 EDD domain protein, DegV family; Region: DegV; TIGR00762 511691003795 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 511691003796 Protein of unknown function (DUF1149); Region: DUF1149; pfam06619 511691003797 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511691003798 ABC transporter signature motif; other site 511691003799 Walker B; other site 511691003800 D-loop; other site 511691003801 H-loop/switch region; other site 511691003802 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 511691003803 active site 511691003804 Beta-lactamase; Region: Beta-lactamase; pfam00144 511691003805 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 511691003806 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 511691003807 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 511691003808 NAD binding site [chemical binding]; other site 511691003809 homodimer interface [polypeptide binding]; other site 511691003810 active site 511691003811 substrate binding site [chemical binding]; other site 511691003812 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 511691003813 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 511691003814 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 511691003815 galactokinase; Provisional; Region: PRK05322 511691003816 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 511691003817 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 511691003818 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 511691003819 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 511691003820 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 511691003821 DNA binding site [nucleotide binding] 511691003822 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 511691003823 putative dimerization interface [polypeptide binding]; other site 511691003824 putative ligand binding site [chemical binding]; other site 511691003825 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 511691003826 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 511691003827 Ca binding site [ion binding]; other site 511691003828 active site 511691003829 catalytic site [active] 511691003830 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 511691003831 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 511691003832 Walker A/P-loop; other site 511691003833 ATP binding site [chemical binding]; other site 511691003834 Q-loop/lid; other site 511691003835 ABC transporter signature motif; other site 511691003836 Walker B; other site 511691003837 D-loop; other site 511691003838 H-loop/switch region; other site 511691003839 TOBE domain; Region: TOBE_2; pfam08402 511691003840 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 511691003841 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 511691003842 active site 511691003843 homodimer interface [polypeptide binding]; other site 511691003844 catalytic site [active] 511691003845 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 511691003846 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511691003847 dimer interface [polypeptide binding]; other site 511691003848 conserved gate region; other site 511691003849 putative PBP binding loops; other site 511691003850 ABC-ATPase subunit interface; other site 511691003851 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511691003852 dimer interface [polypeptide binding]; other site 511691003853 conserved gate region; other site 511691003854 putative PBP binding loops; other site 511691003855 ABC-ATPase subunit interface; other site 511691003856 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 511691003857 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 511691003858 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 511691003859 Melibiase; Region: Melibiase; pfam02065 511691003860 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 511691003861 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 511691003862 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511691003863 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511691003864 IS199 511691003865 HTH-like domain; Region: HTH_21; pfam13276 511691003866 Integrase core domain; Region: rve; pfam00665 511691003867 Integrase core domain; Region: rve_3; pfam13683 511691003868 ISSdy1 511691003869 Transposase; Region: HTH_Tnp_1; pfam01527 511691003870 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 511691003871 Integrase core domain; Region: rve; pfam00665 511691003872 Integrase core domain; Region: rve_2; pfam13333 511691003873 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 511691003874 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 511691003875 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 511691003876 FAD binding site [chemical binding]; other site 511691003877 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 511691003878 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 511691003879 THF binding site; other site 511691003880 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 511691003881 substrate binding site [chemical binding]; other site 511691003882 THF binding site; other site 511691003883 zinc-binding site [ion binding]; other site 511691003884 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 511691003885 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 511691003886 active site 511691003887 phosphorylation site [posttranslational modification] 511691003888 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 511691003889 active site 511691003890 P-loop; other site 511691003891 phosphorylation site [posttranslational modification] 511691003892 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 511691003893 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 511691003894 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 511691003895 putative substrate binding site [chemical binding]; other site 511691003896 putative ATP binding site [chemical binding]; other site 511691003897 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 511691003898 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 511691003899 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 511691003900 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 511691003901 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 511691003902 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 511691003903 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 511691003904 RimM N-terminal domain; Region: RimM; pfam01782 511691003905 PRC-barrel domain; Region: PRC; pfam05239 511691003906 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 511691003907 KH domain; Region: KH_4; pfam13083 511691003908 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 511691003909 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 511691003910 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 511691003911 FtsX-like permease family; Region: FtsX; pfam02687 511691003912 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 511691003913 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 511691003914 Walker A/P-loop; other site 511691003915 ATP binding site [chemical binding]; other site 511691003916 Q-loop/lid; other site 511691003917 ABC transporter signature motif; other site 511691003918 Walker B; other site 511691003919 D-loop; other site 511691003920 H-loop/switch region; other site 511691003921 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 511691003922 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 511691003923 HlyD family secretion protein; Region: HlyD_3; pfam13437 511691003924 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 511691003925 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 511691003926 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 511691003927 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 511691003928 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 511691003929 ATP-grasp domain; Region: ATP-grasp_4; cl17255 511691003930 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 511691003931 IMP binding site; other site 511691003932 dimer interface [polypeptide binding]; other site 511691003933 interdomain contacts; other site 511691003934 partial ornithine binding site; other site 511691003935 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 511691003936 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 511691003937 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 511691003938 catalytic site [active] 511691003939 subunit interface [polypeptide binding]; other site 511691003940 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 511691003941 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 511691003942 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 511691003943 uracil transporter; Provisional; Region: PRK10720 511691003944 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 511691003945 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511691003946 active site 511691003947 Uncharacterized conserved protein [Function unknown]; Region: COG0398 511691003948 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 511691003949 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 511691003950 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 511691003951 RNA binding surface [nucleotide binding]; other site 511691003952 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 511691003953 active site 511691003954 lipoprotein signal peptidase; Provisional; Region: PRK14797 511691003955 Transcriptional regulator [Transcription]; Region: LysR; COG0583 511691003956 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511691003957 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 511691003958 dimerization interface [polypeptide binding]; other site 511691003959 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 511691003960 putative NADH binding site [chemical binding]; other site 511691003961 putative active site [active] 511691003962 nudix motif; other site 511691003963 putative metal binding site [ion binding]; other site 511691003964 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 511691003965 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 511691003966 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 511691003967 Protein of unknown function (DUF464); Region: DUF464; pfam04327 511691003968 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 511691003969 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 511691003970 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511691003971 Coenzyme A binding pocket [chemical binding]; other site 511691003972 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 511691003973 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 511691003974 putative active site [active] 511691003975 putative metal binding site [ion binding]; other site 511691003976 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 511691003977 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 511691003978 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 511691003979 Ligand Binding Site [chemical binding]; other site 511691003980 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 511691003981 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 511691003982 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 511691003983 catalytic residue [active] 511691003984 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 511691003985 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 511691003986 glutathione reductase; Validated; Region: PRK06116 511691003987 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 511691003988 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 511691003989 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 511691003990 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 511691003991 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 511691003992 active site 511691003993 catalytic tetrad [active] 511691003994 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 511691003995 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 511691003996 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 511691003997 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 511691003998 Surface antigen [General function prediction only]; Region: COG3942 511691003999 CHAP domain; Region: CHAP; pfam05257 511691004000 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 511691004001 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 511691004002 Ligand binding site; other site 511691004003 Putative Catalytic site; other site 511691004004 DXD motif; other site 511691004005 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 511691004006 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 511691004007 Ligand binding site; other site 511691004008 Putative Catalytic site; other site 511691004009 DXD motif; other site 511691004010 Sulfatase; Region: Sulfatase; pfam00884 511691004011 Rhamnan synthesis protein F; Region: RgpF; pfam05045 511691004012 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 511691004013 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 511691004014 active site 511691004015 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 511691004016 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 511691004017 Walker A/P-loop; other site 511691004018 ATP binding site [chemical binding]; other site 511691004019 Q-loop/lid; other site 511691004020 ABC transporter signature motif; other site 511691004021 Walker B; other site 511691004022 D-loop; other site 511691004023 H-loop/switch region; other site 511691004024 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 511691004025 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 511691004026 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 511691004027 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 511691004028 Probable Catalytic site; other site 511691004029 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 511691004030 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 511691004031 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 511691004032 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 511691004033 NADP binding site [chemical binding]; other site 511691004034 active site 511691004035 putative substrate binding site [chemical binding]; other site 511691004036 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 511691004037 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 511691004038 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 511691004039 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 511691004040 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 511691004041 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 511691004042 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 511691004043 DNA binding residues [nucleotide binding] 511691004044 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 511691004045 DNA primase; Validated; Region: dnaG; PRK05667 511691004046 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 511691004047 active site 511691004048 metal binding site [ion binding]; metal-binding site 511691004049 interdomain interaction site; other site 511691004050 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 511691004051 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 511691004052 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 511691004053 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 511691004054 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 511691004055 substrate binding pocket [chemical binding]; other site 511691004056 membrane-bound complex binding site; other site 511691004057 hinge residues; other site 511691004058 transaminase; Validated; Region: PRK07324 511691004059 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 511691004060 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511691004061 homodimer interface [polypeptide binding]; other site 511691004062 catalytic residue [active] 511691004063 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 511691004064 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 511691004065 substrate binding pocket [chemical binding]; other site 511691004066 membrane-bound complex binding site; other site 511691004067 hinge residues; other site 511691004068 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 511691004069 putative active site [active] 511691004070 nucleotide binding site [chemical binding]; other site 511691004071 nudix motif; other site 511691004072 putative metal binding site [ion binding]; other site 511691004073 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 511691004074 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511691004075 non-specific DNA binding site [nucleotide binding]; other site 511691004076 salt bridge; other site 511691004077 sequence-specific DNA binding site [nucleotide binding]; other site 511691004078 excinuclease ABC subunit B; Provisional; Region: PRK05298 511691004079 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 511691004080 ATP binding site [chemical binding]; other site 511691004081 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511691004082 nucleotide binding region [chemical binding]; other site 511691004083 ATP-binding site [chemical binding]; other site 511691004084 Ultra-violet resistance protein B; Region: UvrB; pfam12344 511691004085 CAAX protease self-immunity; Region: Abi; pfam02517 511691004086 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 511691004087 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 511691004088 substrate binding pocket [chemical binding]; other site 511691004089 membrane-bound complex binding site; other site 511691004090 hinge residues; other site 511691004091 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 511691004092 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 511691004093 substrate binding pocket [chemical binding]; other site 511691004094 membrane-bound complex binding site; other site 511691004095 hinge residues; other site 511691004096 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511691004097 dimer interface [polypeptide binding]; other site 511691004098 conserved gate region; other site 511691004099 putative PBP binding loops; other site 511691004100 ABC-ATPase subunit interface; other site 511691004101 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 511691004102 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 511691004103 Walker A/P-loop; other site 511691004104 ATP binding site [chemical binding]; other site 511691004105 Q-loop/lid; other site 511691004106 ABC transporter signature motif; other site 511691004107 Walker B; other site 511691004108 D-loop; other site 511691004109 H-loop/switch region; other site 511691004110 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 511691004111 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 511691004112 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 511691004113 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 511691004114 GTPase CgtA; Reviewed; Region: obgE; PRK12297 511691004115 GTP1/OBG; Region: GTP1_OBG; pfam01018 511691004116 Obg GTPase; Region: Obg; cd01898 511691004117 G1 box; other site 511691004118 GTP/Mg2+ binding site [chemical binding]; other site 511691004119 Switch I region; other site 511691004120 G2 box; other site 511691004121 G3 box; other site 511691004122 Switch II region; other site 511691004123 G4 box; other site 511691004124 G5 box; other site 511691004125 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 511691004126 Predicted thioesterase [General function prediction only]; Region: COG5496 511691004127 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 511691004128 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 511691004129 NADP binding site [chemical binding]; other site 511691004130 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 511691004131 active site 511691004132 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 511691004133 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 511691004134 CoenzymeA binding site [chemical binding]; other site 511691004135 subunit interaction site [polypeptide binding]; other site 511691004136 PHB binding site; other site 511691004137 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 511691004138 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511691004139 non-specific DNA binding site [nucleotide binding]; other site 511691004140 salt bridge; other site 511691004141 sequence-specific DNA binding site [nucleotide binding]; other site 511691004142 CAAX protease self-immunity; Region: Abi; pfam02517 511691004143 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 511691004144 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 511691004145 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511691004146 S-adenosylmethionine binding site [chemical binding]; other site 511691004147 Transcriptional regulator [Transcription]; Region: LytR; COG1316 511691004148 prephenate dehydratase; Provisional; Region: PRK11898 511691004149 Prephenate dehydratase; Region: PDT; pfam00800 511691004150 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 511691004151 putative L-Phe binding site [chemical binding]; other site 511691004152 shikimate kinase; Reviewed; Region: aroK; PRK00131 511691004153 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 511691004154 ADP binding site [chemical binding]; other site 511691004155 magnesium binding site [ion binding]; other site 511691004156 putative shikimate binding site; other site 511691004157 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 511691004158 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 511691004159 hinge; other site 511691004160 active site 511691004161 hypothetical protein; Provisional; Region: PRK13676 511691004162 prephenate dehydrogenase; Validated; Region: PRK06545 511691004163 prephenate dehydrogenase; Validated; Region: PRK08507 511691004164 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 511691004165 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 511691004166 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 511691004167 Tetramer interface [polypeptide binding]; other site 511691004168 active site 511691004169 FMN-binding site [chemical binding]; other site 511691004170 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 511691004171 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 511691004172 active site 511691004173 dimer interface [polypeptide binding]; other site 511691004174 metal binding site [ion binding]; metal-binding site 511691004175 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 511691004176 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 511691004177 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 511691004178 NAD(P) binding site [chemical binding]; other site 511691004179 shikimate binding site; other site 511691004180 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 511691004181 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 511691004182 active site 511691004183 catalytic residue [active] 511691004184 dimer interface [polypeptide binding]; other site 511691004185 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 511691004186 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 511691004187 putative RNA binding site [nucleotide binding]; other site 511691004188 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 511691004189 Sulfatase; Region: Sulfatase; pfam00884 511691004190 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 511691004191 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511691004192 motif II; other site 511691004193 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 511691004194 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 511691004195 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 511691004196 dimer interface [polypeptide binding]; other site 511691004197 putative anticodon binding site; other site 511691004198 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 511691004199 motif 1; other site 511691004200 active site 511691004201 motif 2; other site 511691004202 motif 3; other site 511691004203 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 511691004204 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 511691004205 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 511691004206 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 511691004207 Predicted peptidase [General function prediction only]; Region: COG4099 511691004208 manganese transport protein MntH; Reviewed; Region: PRK00701 511691004209 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 511691004210 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 511691004211 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 511691004212 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 511691004213 catalytic residue [active] 511691004214 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 511691004215 catalytic residues [active] 511691004216 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 511691004217 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 511691004218 peroxiredoxin; Region: AhpC; TIGR03137 511691004219 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 511691004220 dimer interface [polypeptide binding]; other site 511691004221 decamer (pentamer of dimers) interface [polypeptide binding]; other site 511691004222 catalytic triad [active] 511691004223 peroxidatic and resolving cysteines [active] 511691004224 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 511691004225 Peptidase family U32; Region: Peptidase_U32; pfam01136 511691004226 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 511691004227 Peptidase family U32; Region: Peptidase_U32; pfam01136 511691004228 Protein of unknown function (DUF3270); Region: DUF3270; pfam11674 511691004229 YtxH-like protein; Region: YtxH; pfam12732 511691004230 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 511691004231 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 511691004232 HPr kinase/phosphorylase; Provisional; Region: PRK05428 511691004233 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 511691004234 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 511691004235 Hpr binding site; other site 511691004236 active site 511691004237 homohexamer subunit interaction site [polypeptide binding]; other site 511691004238 PspC domain; Region: PspC; pfam04024 511691004239 hypothetical protein; Provisional; Region: PRK04351 511691004240 SprT homologues; Region: SprT; cl01182 511691004241 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 511691004242 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 511691004243 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 511691004244 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 511691004245 RNA binding site [nucleotide binding]; other site 511691004246 Predicted permeases [General function prediction only]; Region: COG0701 511691004247 Predicted membrane protein [Function unknown]; Region: COG3689 511691004248 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511691004249 putative substrate translocation pore; other site 511691004250 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511691004251 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511691004252 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 511691004253 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 511691004254 P loop; other site 511691004255 GTP binding site [chemical binding]; other site 511691004256 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511691004257 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 511691004258 active site 511691004259 motif I; other site 511691004260 motif II; other site 511691004261 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511691004262 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511691004263 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 511691004264 active site 511691004265 motif I; other site 511691004266 motif II; other site 511691004267 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 511691004268 Protein of unknown function (DUF3114); Region: DUF3114; pfam11311 511691004269 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 511691004270 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 511691004271 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 511691004272 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 511691004273 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 511691004274 Walker A/P-loop; other site 511691004275 ATP binding site [chemical binding]; other site 511691004276 Q-loop/lid; other site 511691004277 ABC transporter signature motif; other site 511691004278 Walker B; other site 511691004279 D-loop; other site 511691004280 H-loop/switch region; other site 511691004281 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 511691004282 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 511691004283 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 511691004284 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 511691004285 putative NAD(P) binding site [chemical binding]; other site 511691004286 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 511691004287 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 511691004288 DNA binding residues [nucleotide binding] 511691004289 putative dimer interface [polypeptide binding]; other site 511691004290 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 511691004291 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 511691004292 active site 511691004293 metal binding site [ion binding]; metal-binding site 511691004294 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 511691004295 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 511691004296 active site 511691004297 catalytic site [active] 511691004298 metal binding site [ion binding]; metal-binding site 511691004299 dimer interface [polypeptide binding]; other site 511691004300 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 511691004301 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 511691004302 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 511691004303 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 511691004304 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 511691004305 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 511691004306 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 511691004307 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 511691004308 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 511691004309 Zn2+ binding site [ion binding]; other site 511691004310 Mg2+ binding site [ion binding]; other site 511691004311 sugar phosphate phosphatase; Provisional; Region: PRK10513 511691004312 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511691004313 active site 511691004314 motif I; other site 511691004315 motif II; other site 511691004316 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511691004317 FemAB family; Region: FemAB; pfam02388 511691004318 FemAB family; Region: FemAB; pfam02388 511691004319 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 511691004320 triosephosphate isomerase; Provisional; Region: PRK14565 511691004321 substrate binding site [chemical binding]; other site 511691004322 dimer interface [polypeptide binding]; other site 511691004323 catalytic triad [active] 511691004324 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 511691004325 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 511691004326 Walker A/P-loop; other site 511691004327 ATP binding site [chemical binding]; other site 511691004328 Q-loop/lid; other site 511691004329 ABC transporter signature motif; other site 511691004330 Walker B; other site 511691004331 D-loop; other site 511691004332 H-loop/switch region; other site 511691004333 PQQ-like domain; Region: PQQ_2; pfam13360 511691004334 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 511691004335 active site 511691004336 C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cl00298 511691004337 active site 511691004338 elongation factor Tu; Reviewed; Region: PRK00049 511691004339 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 511691004340 G1 box; other site 511691004341 GEF interaction site [polypeptide binding]; other site 511691004342 GTP/Mg2+ binding site [chemical binding]; other site 511691004343 Switch I region; other site 511691004344 G2 box; other site 511691004345 G3 box; other site 511691004346 Switch II region; other site 511691004347 G4 box; other site 511691004348 G5 box; other site 511691004349 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 511691004350 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 511691004351 Antibiotic Binding Site [chemical binding]; other site 511691004352 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 511691004353 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 511691004354 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 511691004355 Inner membrane protein CreD; Region: CreD; cl01844 511691004356 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 511691004357 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 511691004358 active site 511691004359 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 511691004360 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 511691004361 amidase catalytic site [active] 511691004362 Zn binding residues [ion binding]; other site 511691004363 substrate binding site [chemical binding]; other site 511691004364 Predicted membrane protein [Function unknown]; Region: COG2035 511691004365 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 511691004366 putative deacylase active site [active] 511691004367 hypothetical protein; Provisional; Region: PRK11770 511691004368 Domain of unknown function (DUF307); Region: DUF307; pfam03733 511691004369 Domain of unknown function (DUF307); Region: DUF307; pfam03733 511691004370 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 511691004371 catalytic core [active] 511691004372 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 511691004373 23S rRNA binding site [nucleotide binding]; other site 511691004374 L21 binding site [polypeptide binding]; other site 511691004375 L13 binding site [polypeptide binding]; other site 511691004376 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 511691004377 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 511691004378 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 511691004379 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 511691004380 cytidylate kinase; Provisional; Region: cmk; PRK00023 511691004381 AAA domain; Region: AAA_17; pfam13207 511691004382 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 511691004383 CMP-binding site; other site 511691004384 The sites determining sugar specificity; other site 511691004385 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 511691004386 peptidase T; Region: peptidase-T; TIGR01882 511691004387 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 511691004388 metal binding site [ion binding]; metal-binding site 511691004389 dimer interface [polypeptide binding]; other site 511691004390 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 511691004391 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 511691004392 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 511691004393 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 511691004394 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 511691004395 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 511691004396 AtlA is an autolysin found in Gram-positive lactic acid bacteria that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. This family includes the AtlA and Aml...; Region: GH25_AtlA-like; cd06522 511691004397 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 511691004398 active site 511691004399 Flagellin N-methylase; Region: FliB; pfam03692 511691004400 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 511691004401 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 511691004402 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 511691004403 active site 511691004404 catalytic tetrad [active] 511691004405 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 511691004406 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 511691004407 active site 511691004408 catalytic tetrad [active] 511691004409 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 511691004410 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 511691004411 DNA binding residues [nucleotide binding] 511691004412 putative dimer interface [polypeptide binding]; other site 511691004413 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 511691004414 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 511691004415 tetrameric interface [polypeptide binding]; other site 511691004416 activator binding site; other site 511691004417 NADP binding site [chemical binding]; other site 511691004418 substrate binding site [chemical binding]; other site 511691004419 catalytic residues [active] 511691004420 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 511691004421 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 511691004422 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 511691004423 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 511691004424 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 511691004425 dimerization domain swap beta strand [polypeptide binding]; other site 511691004426 regulatory protein interface [polypeptide binding]; other site 511691004427 active site 511691004428 regulatory phosphorylation site [posttranslational modification]; other site 511691004429 Predicted membrane protein [Function unknown]; Region: COG4905 511691004430 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 511691004431 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 511691004432 isocitrate dehydrogenase; Validated; Region: PRK06451 511691004433 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 511691004434 dimer interface [polypeptide binding]; other site 511691004435 Citrate synthase; Region: Citrate_synt; pfam00285 511691004436 active site 511691004437 citrylCoA binding site [chemical binding]; other site 511691004438 oxalacetate/citrate binding site [chemical binding]; other site 511691004439 coenzyme A binding site [chemical binding]; other site 511691004440 catalytic triad [active] 511691004441 aconitate hydratase; Validated; Region: PRK09277 511691004442 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 511691004443 substrate binding site [chemical binding]; other site 511691004444 ligand binding site [chemical binding]; other site 511691004445 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 511691004446 substrate binding site [chemical binding]; other site 511691004447 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 511691004448 catalytic residues [active] 511691004449 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 511691004450 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 511691004451 Class I ribonucleotide reductase; Region: RNR_I; cd01679 511691004452 active site 511691004453 dimer interface [polypeptide binding]; other site 511691004454 catalytic residues [active] 511691004455 effector binding site; other site 511691004456 R2 peptide binding site; other site 511691004457 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 511691004458 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 511691004459 dimer interface [polypeptide binding]; other site 511691004460 putative radical transfer pathway; other site 511691004461 diiron center [ion binding]; other site 511691004462 tyrosyl radical; other site 511691004463 acetylornithine aminotransferase; Provisional; Region: PRK04260 511691004464 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 511691004465 inhibitor-cofactor binding pocket; inhibition site 511691004466 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511691004467 catalytic residue [active] 511691004468 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 511691004469 nucleotide binding site [chemical binding]; other site 511691004470 N-acetyl-L-glutamate binding site [chemical binding]; other site 511691004471 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 511691004472 heterotetramer interface [polypeptide binding]; other site 511691004473 active site pocket [active] 511691004474 cleavage site 511691004475 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 511691004476 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 511691004477 CAAX protease self-immunity; Region: Abi; pfam02517 511691004478 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511691004479 non-specific DNA binding site [nucleotide binding]; other site 511691004480 salt bridge; other site 511691004481 sequence-specific DNA binding site [nucleotide binding]; other site 511691004482 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 511691004483 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 511691004484 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 511691004485 dimer interface [polypeptide binding]; other site 511691004486 phosphorylation site [posttranslational modification] 511691004487 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511691004488 ATP binding site [chemical binding]; other site 511691004489 Mg2+ binding site [ion binding]; other site 511691004490 G-X-G motif; other site 511691004491 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 511691004492 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511691004493 active site 511691004494 phosphorylation site [posttranslational modification] 511691004495 intermolecular recognition site; other site 511691004496 dimerization interface [polypeptide binding]; other site 511691004497 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 511691004498 DNA binding site [nucleotide binding] 511691004499 TraX protein; Region: TraX; cl05434 511691004500 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 511691004501 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 511691004502 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511691004503 dimer interface [polypeptide binding]; other site 511691004504 conserved gate region; other site 511691004505 putative PBP binding loops; other site 511691004506 ABC-ATPase subunit interface; other site 511691004507 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 511691004508 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 511691004509 Walker A/P-loop; other site 511691004510 ATP binding site [chemical binding]; other site 511691004511 Q-loop/lid; other site 511691004512 ABC transporter signature motif; other site 511691004513 Walker B; other site 511691004514 D-loop; other site 511691004515 H-loop/switch region; other site 511691004516 NMT1-like family; Region: NMT1_2; pfam13379 511691004517 NMT1/THI5 like; Region: NMT1; pfam09084 511691004518 substrate binding pocket [chemical binding]; other site 511691004519 membrane-bound complex binding site; other site 511691004520 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 511691004521 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 511691004522 motif 1; other site 511691004523 active site 511691004524 motif 2; other site 511691004525 motif 3; other site 511691004526 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 511691004527 DHHA1 domain; Region: DHHA1; pfam02272 511691004528 Tubby C 2; Region: Tub_2; cl02043 511691004529 foldase protein PrsA; Reviewed; Region: prsA; PRK01326 511691004530 SurA N-terminal domain; Region: SurA_N; pfam09312 511691004531 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 511691004532 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 511691004533 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511691004534 S-adenosylmethionine binding site [chemical binding]; other site 511691004535 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 511691004536 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511691004537 motif II; other site 511691004538 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 511691004539 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 511691004540 active site 511691004541 Zn binding site [ion binding]; other site 511691004542 Competence protein CoiA-like family; Region: CoiA; pfam06054 511691004543 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 511691004544 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 511691004545 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 511691004546 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 511691004547 NAD(P) binding site [chemical binding]; other site 511691004548 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 511691004549 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 511691004550 DNA-binding site [nucleotide binding]; DNA binding site 511691004551 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 511691004552 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511691004553 homodimer interface [polypeptide binding]; other site 511691004554 catalytic residue [active] 511691004555 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511691004556 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 511691004557 Coenzyme A binding pocket [chemical binding]; other site 511691004558 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 511691004559 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 511691004560 RNA binding surface [nucleotide binding]; other site 511691004561 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 511691004562 active site 511691004563 uracil binding [chemical binding]; other site 511691004564 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 511691004565 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 511691004566 active site 511691004567 trimer interface [polypeptide binding]; other site 511691004568 allosteric site; other site 511691004569 active site lid [active] 511691004570 hexamer (dimer of trimers) interface [polypeptide binding]; other site 511691004571 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 511691004572 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 511691004573 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 511691004574 Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775 511691004575 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 511691004576 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 511691004577 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 511691004578 MarR family; Region: MarR_2; pfam12802 511691004579 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 511691004580 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 511691004581 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 511691004582 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 511691004583 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 511691004584 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 511691004585 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 511691004586 IS861 (fragment) 511691004587 putative transposase OrfB; Reviewed; Region: PHA02517 511691004588 HTH-like domain; Region: HTH_21; pfam13276 511691004589 Integrase core domain; Region: rve; pfam00665 511691004590 Integrase core domain; Region: rve_2; pfam13333 511691004591 ISSpn1 511691004592 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 511691004593 Homeodomain-like domain; Region: HTH_23; cl17451 511691004594 Transposase; Region: HTH_Tnp_1; cl17663 511691004595 IS861 511691004596 IS861 fragment 511691004597 Protein of unknown function (DUF805); Region: DUF805; cl01224 511691004598 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 511691004599 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 511691004600 Telomere length regulation protein; Region: Telomere_reg-2; pfam10193 511691004601 Competence protein; Region: Competence; pfam03772 511691004602 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 511691004603 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 511691004604 SLBB domain; Region: SLBB; pfam10531 511691004605 comEA protein; Region: comE; TIGR01259 511691004606 Helix-hairpin-helix motif; Region: HHH; pfam00633 511691004607 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 511691004608 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 511691004609 putative acyl-acceptor binding pocket; other site 511691004610 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 511691004611 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 511691004612 NodB motif; other site 511691004613 active site 511691004614 catalytic site [active] 511691004615 Zn binding site [ion binding]; other site 511691004616 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 511691004617 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 511691004618 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511691004619 S-adenosylmethionine binding site [chemical binding]; other site 511691004620 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 511691004621 GIY-YIG motif/motif A; other site 511691004622 putative active site [active] 511691004623 putative metal binding site [ion binding]; other site 511691004624 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 511691004625 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 511691004626 ATP binding site [chemical binding]; other site 511691004627 Mg++ binding site [ion binding]; other site 511691004628 motif III; other site 511691004629 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511691004630 nucleotide binding region [chemical binding]; other site 511691004631 ATP-binding site [chemical binding]; other site 511691004632 putative cross-wall-targeting lipoprotein signal; Region: strep_RK_lipo; TIGR03726 511691004633 Streptococcal surface antigen repeat; Region: Strep_SA_rep; pfam06696 511691004634 Streptococcal surface antigen repeat; Region: Strep_SA_rep; pfam06696 511691004635 Glucan-binding protein C; Region: GbpC; pfam08363 511691004636 adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228 511691004637 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 511691004638 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 511691004639 Bacterial SH3 domain; Region: SH3_5; pfam08460 511691004640 Bacterial SH3 domain; Region: SH3_5; pfam08460 511691004641 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 511691004642 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 511691004643 Bacterial SH3 domain; Region: SH3_5; pfam08460 511691004644 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 511691004645 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 511691004646 G1 box; other site 511691004647 putative GEF interaction site [polypeptide binding]; other site 511691004648 GTP/Mg2+ binding site [chemical binding]; other site 511691004649 Switch I region; other site 511691004650 G2 box; other site 511691004651 G3 box; other site 511691004652 Switch II region; other site 511691004653 G4 box; other site 511691004654 G5 box; other site 511691004655 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 511691004656 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 511691004657 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 511691004658 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 511691004659 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 511691004660 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 511691004661 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 511691004662 Sodium Bile acid symporter family; Region: SBF; cl17470 511691004663 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 511691004664 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 511691004665 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 511691004666 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 511691004667 recombination protein RecR; Reviewed; Region: recR; PRK00076 511691004668 RecR protein; Region: RecR; pfam02132 511691004669 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 511691004670 putative active site [active] 511691004671 putative metal-binding site [ion binding]; other site 511691004672 tetramer interface [polypeptide binding]; other site 511691004673 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 511691004674 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 511691004675 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 511691004676 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 511691004677 catalytic core [active] 511691004678 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 511691004679 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 511691004680 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 511691004681 active site 511691004682 FMN binding site [chemical binding]; other site 511691004683 substrate binding site [chemical binding]; other site 511691004684 catalytic residues [active] 511691004685 homodimer interface [polypeptide binding]; other site 511691004686 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 511691004687 metal binding site 2 [ion binding]; metal-binding site 511691004688 putative DNA binding helix; other site 511691004689 metal binding site 1 [ion binding]; metal-binding site 511691004690 dimer interface [polypeptide binding]; other site 511691004691 structural Zn2+ binding site [ion binding]; other site 511691004692 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 511691004693 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 511691004694 hypothetical protein; Provisional; Region: PRK14851 511691004695 IS861 fragment 511691004696 IS861 fragment 511691004697 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 511691004698 IHF dimer interface [polypeptide binding]; other site 511691004699 IHF - DNA interface [nucleotide binding]; other site 511691004700 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 511691004701 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 511691004702 active site 511691004703 catalytic triad [active] 511691004704 oxyanion hole [active] 511691004705 EDD domain protein, DegV family; Region: DegV; TIGR00762 511691004706 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 511691004707 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 511691004708 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 511691004709 Walker A/P-loop; other site 511691004710 ATP binding site [chemical binding]; other site 511691004711 Q-loop/lid; other site 511691004712 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 511691004713 ABC transporter signature motif; other site 511691004714 Walker B; other site 511691004715 D-loop; other site 511691004716 H-loop/switch region; other site 511691004717 Arginine repressor [Transcription]; Region: ArgR; COG1438 511691004718 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 511691004719 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 511691004720 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 511691004721 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 511691004722 RNA binding surface [nucleotide binding]; other site 511691004723 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 511691004724 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 511691004725 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 511691004726 substrate binding pocket [chemical binding]; other site 511691004727 chain length determination region; other site 511691004728 substrate-Mg2+ binding site; other site 511691004729 catalytic residues [active] 511691004730 aspartate-rich region 1; other site 511691004731 active site lid residues [active] 511691004732 aspartate-rich region 2; other site 511691004733 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 511691004734 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 511691004735 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 511691004736 generic binding surface II; other site 511691004737 generic binding surface I; other site 511691004738 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 511691004739 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 511691004740 GAF domain; Region: GAF_3; pfam13492 511691004741 Histidine kinase; Region: His_kinase; pfam06580 511691004742 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511691004743 ATP binding site [chemical binding]; other site 511691004744 Mg2+ binding site [ion binding]; other site 511691004745 G-X-G motif; other site 511691004746 two-component response regulator; Provisional; Region: PRK14084 511691004747 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511691004748 active site 511691004749 phosphorylation site [posttranslational modification] 511691004750 intermolecular recognition site; other site 511691004751 dimerization interface [polypeptide binding]; other site 511691004752 LytTr DNA-binding domain; Region: LytTR; pfam04397 511691004753 LrgA family; Region: LrgA; cl00608 511691004754 LrgB-like family; Region: LrgB; cl00596 511691004755 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 511691004756 putative substrate binding site [chemical binding]; other site 511691004757 putative ATP binding site [chemical binding]; other site 511691004758 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179 511691004759 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 511691004760 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 511691004761 homodimer interface [polypeptide binding]; other site 511691004762 NADP binding site [chemical binding]; other site 511691004763 substrate binding site [chemical binding]; other site 511691004764 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 511691004765 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 511691004766 G1 box; other site 511691004767 GTP/Mg2+ binding site [chemical binding]; other site 511691004768 Switch I region; other site 511691004769 G2 box; other site 511691004770 G3 box; other site 511691004771 Switch II region; other site 511691004772 G4 box; other site 511691004773 G5 box; other site 511691004774 Nucleoside recognition; Region: Gate; pfam07670 511691004775 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 511691004776 Nucleoside recognition; Region: Gate; pfam07670 511691004777 FeoA domain; Region: FeoA; pfam04023 511691004778 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 511691004779 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 511691004780 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 511691004781 Walker A/P-loop; other site 511691004782 ATP binding site [chemical binding]; other site 511691004783 Q-loop/lid; other site 511691004784 ABC transporter signature motif; other site 511691004785 Walker B; other site 511691004786 D-loop; other site 511691004787 H-loop/switch region; other site 511691004788 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 511691004789 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511691004790 dimer interface [polypeptide binding]; other site 511691004791 conserved gate region; other site 511691004792 putative PBP binding loops; other site 511691004793 ABC-ATPase subunit interface; other site 511691004794 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 511691004795 ornithine carbamoyltransferase; Validated; Region: PRK02102 511691004796 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 511691004797 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 511691004798 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511691004799 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 511691004800 Walker A motif; other site 511691004801 ATP binding site [chemical binding]; other site 511691004802 Walker B motif; other site 511691004803 arginine finger; other site 511691004804 UvrB/uvrC motif; Region: UVR; pfam02151 511691004805 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511691004806 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 511691004807 Walker A motif; other site 511691004808 ATP binding site [chemical binding]; other site 511691004809 Walker B motif; other site 511691004810 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 511691004811 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 511691004812 nudix motif; other site 511691004813 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 511691004814 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 511691004815 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 511691004816 active site 511691004817 HIGH motif; other site 511691004818 nucleotide binding site [chemical binding]; other site 511691004819 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 511691004820 active site 511691004821 KMSKS motif; other site 511691004822 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 511691004823 tRNA binding surface [nucleotide binding]; other site 511691004824 anticodon binding site; other site 511691004825 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 511691004826 DivIVA protein; Region: DivIVA; pfam05103 511691004827 DivIVA domain; Region: DivI1A_domain; TIGR03544 511691004828 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 511691004829 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 511691004830 RNA binding surface [nucleotide binding]; other site 511691004831 YGGT family; Region: YGGT; pfam02325 511691004832 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 511691004833 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 511691004834 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 511691004835 catalytic residue [active] 511691004836 cell division protein FtsZ; Validated; Region: PRK09330 511691004837 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 511691004838 nucleotide binding site [chemical binding]; other site 511691004839 SulA interaction site; other site 511691004840 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 511691004841 Cell division protein FtsA; Region: FtsA; smart00842 511691004842 Cell division protein FtsA; Region: FtsA; pfam14450 511691004843 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 511691004844 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 511691004845 Cell division protein FtsQ; Region: FtsQ; pfam03799 511691004846 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 511691004847 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 511691004848 active site 511691004849 homodimer interface [polypeptide binding]; other site 511691004850 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 511691004851 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 511691004852 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 511691004853 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 511691004854 Protein of unknown function (DUF3165); Region: DUF3165; pfam11364 511691004855 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 511691004856 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 511691004857 G1 box; other site 511691004858 putative GEF interaction site [polypeptide binding]; other site 511691004859 GTP/Mg2+ binding site [chemical binding]; other site 511691004860 Switch I region; other site 511691004861 G2 box; other site 511691004862 G3 box; other site 511691004863 Switch II region; other site 511691004864 G4 box; other site 511691004865 G5 box; other site 511691004866 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 511691004867 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 511691004868 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 511691004869 active site residue [active] 511691004870 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 511691004871 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 511691004872 nucleotide binding site [chemical binding]; other site 511691004873 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 511691004874 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 511691004875 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 511691004876 dimerization interface [polypeptide binding]; other site 511691004877 DPS ferroxidase diiron center [ion binding]; other site 511691004878 ion pore; other site 511691004879 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 511691004880 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 511691004881 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 511691004882 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 511691004883 substrate binding site [chemical binding]; other site 511691004884 active site 511691004885 catalytic residues [active] 511691004886 heterodimer interface [polypeptide binding]; other site 511691004887 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 511691004888 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 511691004889 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511691004890 catalytic residue [active] 511691004891 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 511691004892 active site 511691004893 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 511691004894 active site 511691004895 ribulose/triose binding site [chemical binding]; other site 511691004896 phosphate binding site [ion binding]; other site 511691004897 substrate (anthranilate) binding pocket [chemical binding]; other site 511691004898 product (indole) binding pocket [chemical binding]; other site 511691004899 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 511691004900 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 511691004901 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 511691004902 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 511691004903 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 511691004904 glutamine binding [chemical binding]; other site 511691004905 catalytic triad [active] 511691004906 anthranilate synthase component I; Provisional; Region: PRK13570 511691004907 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 511691004908 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 511691004909 Chorismate mutase type II; Region: CM_2; smart00830 511691004910 Protein of unknown function (DUF975); Region: DUF975; pfam06161 511691004911 Uncharacterized conserved protein [Function unknown]; Region: COG1359 511691004912 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 511691004913 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 511691004914 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 511691004915 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 511691004916 DNA binding residues [nucleotide binding] 511691004917 drug binding residues [chemical binding]; other site 511691004918 dimer interface [polypeptide binding]; other site 511691004919 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 511691004920 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 511691004921 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 511691004922 Walker A/P-loop; other site 511691004923 ATP binding site [chemical binding]; other site 511691004924 Q-loop/lid; other site 511691004925 ABC transporter signature motif; other site 511691004926 Walker B; other site 511691004927 D-loop; other site 511691004928 H-loop/switch region; other site 511691004929 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 511691004930 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 511691004931 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511691004932 Walker A/P-loop; other site 511691004933 ATP binding site [chemical binding]; other site 511691004934 Q-loop/lid; other site 511691004935 ABC transporter signature motif; other site 511691004936 Walker B; other site 511691004937 D-loop; other site 511691004938 H-loop/switch region; other site 511691004939 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 511691004940 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511691004941 FeS/SAM binding site; other site 511691004942 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 511691004943 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 511691004944 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 511691004945 active site 511691004946 metal binding site [ion binding]; metal-binding site 511691004947 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 511691004948 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 511691004949 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 511691004950 protein binding site [polypeptide binding]; other site 511691004951 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 511691004952 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 511691004953 active site 511691004954 (T/H)XGH motif; other site 511691004955 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 511691004956 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511691004957 S-adenosylmethionine binding site [chemical binding]; other site 511691004958 myosin-cross-reactive antigen; Provisional; Region: PRK13977 511691004959 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 511691004960 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 511691004961 AAA domain; Region: AAA_33; pfam13671 511691004962 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 511691004963 intersubunit interface [polypeptide binding]; other site 511691004964 active site 511691004965 zinc binding site [ion binding]; other site 511691004966 Na+ binding site [ion binding]; other site 511691004967 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 511691004968 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 511691004969 active site 511691004970 P-loop; other site 511691004971 phosphorylation site [posttranslational modification] 511691004972 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 511691004973 PRD domain; Region: PRD; pfam00874 511691004974 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 511691004975 active site 511691004976 P-loop; other site 511691004977 phosphorylation site [posttranslational modification] 511691004978 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 511691004979 active site 511691004980 phosphorylation site [posttranslational modification] 511691004981 Protein of unknown function (DUF419); Region: DUF419; cl15265 511691004982 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511691004983 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 511691004984 active site 511691004985 motif I; other site 511691004986 motif II; other site 511691004987 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511691004988 motif II; other site 511691004989 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 511691004990 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 511691004991 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 511691004992 DpnII restriction endonuclease; Region: DpnII; pfam04556 511691004993 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 511691004994 DNA methylase; Region: N6_N4_Mtase; pfam01555 511691004995 DNA adenine methylase (dam); Region: dam; TIGR00571 511691004996 Predicted membrane protein [Function unknown]; Region: COG4640 511691004997 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 511691004998 30S subunit binding site; other site 511691004999 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 511691005000 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511691005001 active site 511691005002 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 511691005003 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 511691005004 ATP binding site [chemical binding]; other site 511691005005 putative Mg++ binding site [ion binding]; other site 511691005006 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511691005007 nucleotide binding region [chemical binding]; other site 511691005008 ATP-binding site [chemical binding]; other site 511691005009 Uncharacterized conserved protein [Function unknown]; Region: COG1739 511691005010 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 511691005011 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 511691005012 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 511691005013 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 511691005014 dimer interface [polypeptide binding]; other site 511691005015 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511691005016 catalytic residue [active] 511691005017 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 511691005018 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 511691005019 dimer interface [polypeptide binding]; other site 511691005020 active site 511691005021 metal binding site [ion binding]; metal-binding site 511691005022 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 511691005023 active site 511691005024 intersubunit interactions; other site 511691005025 catalytic residue [active] 511691005026 Pyruvate-formate lyase [Energy production and conversion]; Region: PflD; COG1882 511691005027 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 511691005028 dimer interface [polypeptide binding]; other site 511691005029 active site 511691005030 glycine loop; other site 511691005031 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 511691005032 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 511691005033 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 511691005034 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 511691005035 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511691005036 FeS/SAM binding site; other site 511691005037 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 511691005038 hypothetical protein; Provisional; Region: PRK07252 511691005039 RNA binding site [nucleotide binding]; other site 511691005040 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511691005041 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 511691005042 active site 511691005043 motif I; other site 511691005044 motif II; other site 511691005045 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 511691005046 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 511691005047 active site 511691005048 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 511691005049 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 511691005050 active site 511691005051 phosphorylation site [posttranslational modification] 511691005052 intermolecular recognition site; other site 511691005053 dimerization interface [polypeptide binding]; other site 511691005054 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 511691005055 DNA binding residues [nucleotide binding] 511691005056 dimerization interface [polypeptide binding]; other site 511691005057 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 511691005058 Histidine kinase; Region: HisKA_3; pfam07730 511691005059 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 511691005060 ATP binding site [chemical binding]; other site 511691005061 Mg2+ binding site [ion binding]; other site 511691005062 G-X-G motif; other site 511691005063 Predicted membrane protein [Function unknown]; Region: COG4758 511691005064 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 511691005065 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 511691005066 Catalytic domain of Protein Kinases; Region: PKc; cd00180 511691005067 active site 511691005068 ATP binding site [chemical binding]; other site 511691005069 substrate binding site [chemical binding]; other site 511691005070 activation loop (A-loop); other site 511691005071 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 511691005072 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 511691005073 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 511691005074 PASTA domain; Region: PASTA; pfam03793 511691005075 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 511691005076 active site 511691005077 16S rRNA methyltransferase B; Provisional; Region: PRK14902 511691005078 NusB family; Region: NusB; pfam01029 511691005079 putative RNA binding site [nucleotide binding]; other site 511691005080 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511691005081 S-adenosylmethionine binding site [chemical binding]; other site 511691005082 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 511691005083 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 511691005084 putative active site [active] 511691005085 substrate binding site [chemical binding]; other site 511691005086 putative cosubstrate binding site; other site 511691005087 catalytic site [active] 511691005088 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 511691005089 substrate binding site [chemical binding]; other site 511691005090 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 511691005091 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 511691005092 ATP binding site [chemical binding]; other site 511691005093 putative Mg++ binding site [ion binding]; other site 511691005094 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511691005095 nucleotide binding region [chemical binding]; other site 511691005096 ATP-binding site [chemical binding]; other site 511691005097 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 511691005098 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 511691005099 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 511691005100 catalytic site [active] 511691005101 G-X2-G-X-G-K; other site 511691005102 hypothetical protein; Provisional; Region: PRK00106 511691005103 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 511691005104 Zn2+ binding site [ion binding]; other site 511691005105 Mg2+ binding site [ion binding]; other site 511691005106 S-ribosylhomocysteinase; Provisional; Region: PRK02260 511691005107 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 511691005108 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 511691005109 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 511691005110 cell division protein GpsB; Provisional; Region: PRK14127 511691005111 DivIVA domain; Region: DivI1A_domain; TIGR03544 511691005112 hypothetical protein; Provisional; Region: PRK13660 511691005113 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 511691005114 Transglycosylase; Region: Transgly; pfam00912 511691005115 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 511691005116 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 511691005117 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 511691005118 trimer interface [polypeptide binding]; other site 511691005119 active site 511691005120 G bulge; other site 511691005121 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 511691005122 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 511691005123 homodimer interface [polypeptide binding]; other site 511691005124 NAD binding pocket [chemical binding]; other site 511691005125 ATP binding pocket [chemical binding]; other site 511691005126 Mg binding site [ion binding]; other site 511691005127 active-site loop [active] 511691005128 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 511691005129 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 511691005130 active site 511691005131 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 511691005132 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 511691005133 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 511691005134 Protein of unknown function (DUF4059); Region: DUF4059; pfam13268 511691005135 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 511691005136 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 511691005137 Walker A/P-loop; other site 511691005138 ATP binding site [chemical binding]; other site 511691005139 Q-loop/lid; other site 511691005140 ABC transporter signature motif; other site 511691005141 Walker B; other site 511691005142 D-loop; other site 511691005143 H-loop/switch region; other site 511691005144 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 511691005145 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511691005146 dimer interface [polypeptide binding]; other site 511691005147 conserved gate region; other site 511691005148 putative PBP binding loops; other site 511691005149 ABC-ATPase subunit interface; other site 511691005150 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 511691005151 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 511691005152 substrate binding pocket [chemical binding]; other site 511691005153 membrane-bound complex binding site; other site 511691005154 hinge residues; other site 511691005155 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 511691005156 DEAD-like helicases superfamily; Region: DEXDc; smart00487 511691005157 ATP binding site [chemical binding]; other site 511691005158 Mg++ binding site [ion binding]; other site 511691005159 motif III; other site 511691005160 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 511691005161 nucleotide binding region [chemical binding]; other site 511691005162 ATP-binding site [chemical binding]; other site 511691005163 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 511691005164 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 511691005165 Mg++ binding site [ion binding]; other site 511691005166 putative catalytic motif [active] 511691005167 putative substrate binding site [chemical binding]; other site 511691005168 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 511691005169 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 511691005170 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 511691005171 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 511691005172 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 511691005173 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 511691005174 MraW methylase family; Region: Methyltransf_5; pfam01795 511691005175 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 511691005176 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 511691005177 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 511691005178 putative catalytic cysteine [active] 511691005179 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 511691005180 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 511691005181 nucleotide binding site [chemical binding]; other site 511691005182 homotetrameric interface [polypeptide binding]; other site 511691005183 putative phosphate binding site [ion binding]; other site 511691005184 putative allosteric binding site; other site 511691005185 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 511691005186 hypothetical protein; Provisional; Region: PRK02539 511691005187 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 511691005188 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 511691005189 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 511691005190 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 511691005191 dimer interface [polypeptide binding]; other site 511691005192 motif 1; other site 511691005193 active site 511691005194 motif 2; other site 511691005195 motif 3; other site 511691005196 hypothetical protein; Provisional; Region: PRK02268 511691005197 Transcriptional regulators [Transcription]; Region: MarR; COG1846 511691005198 MarR family; Region: MarR; pfam01047 511691005199 MarR family; Region: MarR_2; cl17246 511691005200 Ligand-binding SRPBCC domain of Streptococcus mutans Smu.440 and related proteins; Region: SRPBCC_Smu440-like; cd08862 511691005201 putative hydrophobic ligand binding site [chemical binding]; other site 511691005202 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 511691005203 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 511691005204 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 511691005205 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 511691005206 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 511691005207 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 511691005208 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 511691005209 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 511691005210 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 511691005211 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 511691005212 active site 511691005213 dimer interface [polypeptide binding]; other site 511691005214 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 511691005215 LytTr DNA-binding domain; Region: LytTR; pfam04397 511691005216 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 511691005217 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 511691005218 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 511691005219 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511691005220 Walker A/P-loop; other site 511691005221 ATP binding site [chemical binding]; other site 511691005222 Q-loop/lid; other site 511691005223 ABC transporter signature motif; other site 511691005224 Walker B; other site 511691005225 D-loop; other site 511691005226 H-loop/switch region; other site 511691005227 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 511691005228 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 511691005229 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511691005230 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 511691005231 active site 511691005232 motif I; other site 511691005233 motif II; other site 511691005234 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511691005235 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 511691005236 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 511691005237 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 511691005238 metal-binding site [ion binding] 511691005239 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 511691005240 Soluble P-type ATPase [General function prediction only]; Region: COG4087 511691005241 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 511691005242 Penicillinase repressor; Region: Pencillinase_R; pfam03965 511691005243 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 511691005244 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 511691005245 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 511691005246 translation initiation factor IF-2; Region: IF-2; TIGR00487 511691005247 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 511691005248 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 511691005249 G1 box; other site 511691005250 putative GEF interaction site [polypeptide binding]; other site 511691005251 GTP/Mg2+ binding site [chemical binding]; other site 511691005252 Switch I region; other site 511691005253 G2 box; other site 511691005254 G3 box; other site 511691005255 Switch II region; other site 511691005256 G4 box; other site 511691005257 G5 box; other site 511691005258 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 511691005259 Translation-initiation factor 2; Region: IF-2; pfam11987 511691005260 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 511691005261 hypothetical protein; Provisional; Region: PRK07283 511691005262 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 511691005263 putative RNA binding cleft [nucleotide binding]; other site 511691005264 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 511691005265 NusA N-terminal domain; Region: NusA_N; pfam08529 511691005266 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 511691005267 RNA binding site [nucleotide binding]; other site 511691005268 homodimer interface [polypeptide binding]; other site 511691005269 NusA-like KH domain; Region: KH_5; pfam13184 511691005270 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 511691005271 G-X-X-G motif; other site 511691005272 ribosome maturation protein RimP; Reviewed; Region: PRK00092 511691005273 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 511691005274 putative oligomer interface [polypeptide binding]; other site 511691005275 putative RNA binding site [nucleotide binding]; other site 511691005276 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511691005277 S-adenosylmethionine binding site [chemical binding]; other site 511691005278 Thiamine kinase and related kinases [Coenzyme transport and metabolism]; Region: ycfN; COG0510 511691005279 Phosphotransferase enzyme family; Region: APH; pfam01636 511691005280 substrate binding site [chemical binding]; other site 511691005281 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 511691005282 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 511691005283 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 511691005284 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 511691005285 Walker A/P-loop; other site 511691005286 ATP binding site [chemical binding]; other site 511691005287 Q-loop/lid; other site 511691005288 ABC transporter signature motif; other site 511691005289 Walker B; other site 511691005290 D-loop; other site 511691005291 H-loop/switch region; other site 511691005292 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 511691005293 HIT family signature motif; other site 511691005294 catalytic residue [active] 511691005295 Transcriptional regulator [Transcription]; Region: LytR; COG1316 511691005296 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 511691005297 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 511691005298 Protein of unknown function (DUF1361); Region: DUF1361; pfam07099 511691005299 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 511691005300 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 511691005301 active site 511691005302 motif I; other site 511691005303 motif II; other site 511691005304 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 511691005305 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511691005306 non-specific DNA binding site [nucleotide binding]; other site 511691005307 salt bridge; other site 511691005308 sequence-specific DNA binding site [nucleotide binding]; other site 511691005309 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 511691005310 active site 511691005311 DNA polymerase IV; Validated; Region: PRK02406 511691005312 DNA binding site [nucleotide binding] 511691005313 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 511691005314 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 511691005315 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 511691005316 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511691005317 Coenzyme A binding pocket [chemical binding]; other site 511691005318 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 511691005319 Beta-lactamase; Region: Beta-lactamase; pfam00144 511691005320 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 511691005321 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 511691005322 amphipathic channel; other site 511691005323 Asn-Pro-Ala signature motifs; other site 511691005324 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 511691005325 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; pfam09168 511691005326 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 511691005327 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 511691005328 hypothetical protein; Validated; Region: PRK00153 511691005329 Predicted transcriptional regulators [Transcription]; Region: COG1733 511691005330 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 511691005331 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 511691005332 dimer interface [polypeptide binding]; other site 511691005333 FMN binding site [chemical binding]; other site 511691005334 Protein of unknown function, DUF536; Region: DUF536; pfam04394 511691005335 HI0933-like protein; Region: HI0933_like; pfam03486 511691005336 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 511691005337 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 511691005338 Predicted membrane protein [Function unknown]; Region: COG4392 511691005339 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 511691005340 UGMP family protein; Validated; Region: PRK09604 511691005341 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 511691005342 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 511691005343 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 511691005344 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511691005345 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 511691005346 Coenzyme A binding pocket [chemical binding]; other site 511691005347 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 511691005348 Glycoprotease family; Region: Peptidase_M22; pfam00814 511691005349 Transcriptional regulators [Transcription]; Region: MarR; COG1846 511691005350 MarR family; Region: MarR_2; pfam12802 511691005351 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 511691005352 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 511691005353 putative NADP binding site [chemical binding]; other site 511691005354 putative substrate binding site [chemical binding]; other site 511691005355 active site 511691005356 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 511691005357 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 511691005358 active site 511691005359 catalytic tetrad [active] 511691005360 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 511691005361 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 511691005362 Walker A/P-loop; other site 511691005363 ATP binding site [chemical binding]; other site 511691005364 Q-loop/lid; other site 511691005365 ABC transporter signature motif; other site 511691005366 Walker B; other site 511691005367 D-loop; other site 511691005368 H-loop/switch region; other site 511691005369 hypothetical protein; Provisional; Region: PRK13667 511691005370 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 511691005371 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 511691005372 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 511691005373 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 511691005374 Surface antigen [General function prediction only]; Region: COG3942 511691005375 CHAP domain; Region: CHAP; pfam05257 511691005376 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 511691005377 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 511691005378 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 511691005379 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 511691005380 active site 511691005381 dimer interface [polypeptide binding]; other site 511691005382 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 511691005383 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 511691005384 active site 511691005385 FMN binding site [chemical binding]; other site 511691005386 substrate binding site [chemical binding]; other site 511691005387 3Fe-4S cluster binding site [ion binding]; other site 511691005388 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 511691005389 domain interface; other site 511691005390 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 511691005391 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 511691005392 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 511691005393 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 511691005394 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 511691005395 DNA binding residues [nucleotide binding] 511691005396 putative dimer interface [polypeptide binding]; other site 511691005397 Predicted membrane protein [Function unknown]; Region: COG4129 511691005398 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 511691005399 Phosphoglycerate kinase; Region: PGK; pfam00162 511691005400 substrate binding site [chemical binding]; other site 511691005401 hinge regions; other site 511691005402 ADP binding site [chemical binding]; other site 511691005403 catalytic site [active] 511691005404 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 511691005405 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 511691005406 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 511691005407 elongation factor G; Reviewed; Region: PRK00007 511691005408 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 511691005409 G1 box; other site 511691005410 putative GEF interaction site [polypeptide binding]; other site 511691005411 GTP/Mg2+ binding site [chemical binding]; other site 511691005412 Switch I region; other site 511691005413 G2 box; other site 511691005414 G3 box; other site 511691005415 Switch II region; other site 511691005416 G4 box; other site 511691005417 G5 box; other site 511691005418 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 511691005419 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 511691005420 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 511691005421 30S ribosomal protein S7; Validated; Region: PRK05302 511691005422 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 511691005423 S17 interaction site [polypeptide binding]; other site 511691005424 S8 interaction site; other site 511691005425 16S rRNA interaction site [nucleotide binding]; other site 511691005426 streptomycin interaction site [chemical binding]; other site 511691005427 23S rRNA interaction site [nucleotide binding]; other site 511691005428 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 511691005429 pur operon repressor; Provisional; Region: PRK09213 511691005430 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 511691005431 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 511691005432 active site 511691005433 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 511691005434 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 511691005435 generic binding surface II; other site 511691005436 generic binding surface I; other site 511691005437 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 511691005438 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 511691005439 Zn2+ binding site [ion binding]; other site 511691005440 Mg2+ binding site [ion binding]; other site 511691005441 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 511691005442 RmuC family; Region: RmuC; pfam02646 511691005443 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 511691005444 Thiamine pyrophosphokinase; Region: TPK; cd07995 511691005445 active site 511691005446 dimerization interface [polypeptide binding]; other site 511691005447 thiamine binding site [chemical binding]; other site 511691005448 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 511691005449 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 511691005450 substrate binding site [chemical binding]; other site 511691005451 hexamer interface [polypeptide binding]; other site 511691005452 metal binding site [ion binding]; metal-binding site 511691005453 GTPase RsgA; Reviewed; Region: PRK00098 511691005454 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 511691005455 RNA binding site [nucleotide binding]; other site 511691005456 homodimer interface [polypeptide binding]; other site 511691005457 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 511691005458 GTPase/Zn-binding domain interface [polypeptide binding]; other site 511691005459 GTP/Mg2+ binding site [chemical binding]; other site 511691005460 G4 box; other site 511691005461 G1 box; other site 511691005462 Switch I region; other site 511691005463 G2 box; other site 511691005464 G3 box; other site 511691005465 Switch II region; other site 511691005466 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 511691005467 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511691005468 S-adenosylmethionine binding site [chemical binding]; other site 511691005469 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 511691005470 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 511691005471 putative active site [active] 511691005472 putative NTP binding site [chemical binding]; other site 511691005473 putative nucleic acid binding site [nucleotide binding]; other site 511691005474 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 511691005475 nucleotide binding site/active site [active] 511691005476 HIT family signature motif; other site 511691005477 catalytic residue [active] 511691005478 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 511691005479 dimer interface [polypeptide binding]; other site 511691005480 FMN binding site [chemical binding]; other site 511691005481 Predicted transcriptional regulators [Transcription]; Region: COG1733 511691005482 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 511691005483 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 511691005484 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 511691005485 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 511691005486 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 511691005487 putative active site [active] 511691005488 putative metal binding site [ion binding]; other site 511691005489 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 511691005490 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 511691005491 active site 511691005492 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 511691005493 Protein of unknown function (DUF998); Region: DUF998; pfam06197 511691005494 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 511691005495 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 511691005496 G-X-X-G motif; other site 511691005497 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 511691005498 RxxxH motif; other site 511691005499 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 511691005500 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 511691005501 ribonuclease P; Reviewed; Region: rnpA; PRK00499 511691005502 argininosuccinate lyase; Provisional; Region: PRK00855 511691005503 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 511691005504 active sites [active] 511691005505 tetramer interface [polypeptide binding]; other site 511691005506 argininosuccinate synthase; Provisional; Region: PRK13820 511691005507 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 511691005508 ANP binding site [chemical binding]; other site 511691005509 Substrate Binding Site II [chemical binding]; other site 511691005510 Substrate Binding Site I [chemical binding]; other site 511691005511 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 511691005512 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 511691005513 HTH domain; Region: HTH_11; pfam08279 511691005514 3H domain; Region: 3H; pfam02829 511691005515 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 511691005516 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 511691005517 active site 511691005518 HIGH motif; other site 511691005519 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 511691005520 active site 511691005521 KMSKS motif; other site 511691005522 Uncharacterized conserved protein [Function unknown]; Region: COG2013 511691005523 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 511691005524 active site clefts [active] 511691005525 zinc binding site [ion binding]; other site 511691005526 dimer interface [polypeptide binding]; other site 511691005527 DNA repair protein RadA; Provisional; Region: PRK11823 511691005528 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 511691005529 Walker A motif/ATP binding site; other site 511691005530 ATP binding site [chemical binding]; other site 511691005531 Walker B motif; other site 511691005532 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 511691005533 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 511691005534 catalytic triad [active] 511691005535 conserved cis-peptide bond; other site 511691005536 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 511691005537 trimer interface [polypeptide binding]; other site 511691005538 active site 511691005539 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 511691005540 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 511691005541 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 511691005542 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 511691005543 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 511691005544 active site 511691005545 tetramer interface; other site 511691005546 Rhomboid family; Region: Rhomboid; pfam01694 511691005547 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 511691005548 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 511691005549 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 511691005550 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 511691005551 metal binding site [ion binding]; metal-binding site 511691005552 putative dimer interface [polypeptide binding]; other site 511691005553 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 511691005554 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 511691005555 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 511691005556 putative trimer interface [polypeptide binding]; other site 511691005557 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 511691005558 putative CoA binding site [chemical binding]; other site 511691005559 putative trimer interface [polypeptide binding]; other site 511691005560 putative CoA binding site [chemical binding]; other site 511691005561 Class I aldolases; Region: Aldolase_Class_I; cl17187 511691005562 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 511691005563 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 511691005564 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 511691005565 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 511691005566 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 511691005567 Glucitol operon activator protein (GutM); Region: GutM; pfam06923 511691005568 putative frv operon regulatory protein; Provisional; Region: PRK09863 511691005569 HTH domain; Region: HTH_11; pfam08279 511691005570 PRD domain; Region: PRD; pfam00874 511691005571 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 511691005572 active site 511691005573 P-loop; other site 511691005574 phosphorylation site [posttranslational modification] 511691005575 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 511691005576 active site 511691005577 phosphorylation site [posttranslational modification] 511691005578 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 511691005579 classical (c) SDRs; Region: SDR_c; cd05233 511691005580 NAD(P) binding site [chemical binding]; other site 511691005581 active site 511691005582 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 511691005583 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 511691005584 active site 511691005585 dimer interface [polypeptide binding]; other site 511691005586 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 511691005587 dimer interface [polypeptide binding]; other site 511691005588 active site 511691005589 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 511691005590 Isochorismatase family; Region: Isochorismatase; pfam00857 511691005591 catalytic triad [active] 511691005592 conserved cis-peptide bond; other site 511691005593 IS861 fragment 511691005594 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 511691005595 classical (c) SDRs; Region: SDR_c; cd05233 511691005596 NAD(P) binding site [chemical binding]; other site 511691005597 active site 511691005598 S-adenosylmethionine synthetase; Validated; Region: PRK05250 511691005599 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 511691005600 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 511691005601 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 511691005602 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 511691005603 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 511691005604 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 511691005605 FtsX-like permease family; Region: FtsX; pfam02687 511691005606 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 511691005607 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 511691005608 Walker A/P-loop; other site 511691005609 ATP binding site [chemical binding]; other site 511691005610 Q-loop/lid; other site 511691005611 ABC transporter signature motif; other site 511691005612 Walker B; other site 511691005613 D-loop; other site 511691005614 H-loop/switch region; other site 511691005615 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07769 511691005616 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 511691005617 acyl-activating enzyme (AAE) consensus motif; other site 511691005618 active site 511691005619 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 511691005620 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 511691005621 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511691005622 Walker A/P-loop; other site 511691005623 ATP binding site [chemical binding]; other site 511691005624 Q-loop/lid; other site 511691005625 ABC transporter signature motif; other site 511691005626 Walker B; other site 511691005627 D-loop; other site 511691005628 H-loop/switch region; other site 511691005629 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 511691005630 S-adenosylmethionine binding site [chemical binding]; other site 511691005631 Condensation domain; Region: Condensation; pfam00668 511691005632 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 511691005633 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 511691005634 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 511691005635 acyl-activating enzyme (AAE) consensus motif; other site 511691005636 AMP binding site [chemical binding]; other site 511691005637 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 511691005638 thioester reductase domain; Region: Thioester-redct; TIGR01746 511691005639 extended (e) SDRs, subgroup 1; Region: SDR_e1; cd05235 511691005640 putative NAD(P) binding site [chemical binding]; other site 511691005641 active site 511691005642 putative substrate binding site [chemical binding]; other site 511691005643 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 511691005644 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 511691005645 active site 511691005646 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 511691005647 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 511691005648 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 511691005649 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 511691005650 active site 511691005651 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 511691005652 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 511691005653 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 511691005654 Condensation domain; Region: Condensation; pfam00668 511691005655 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 511691005656 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 511691005657 acyl-activating enzyme (AAE) consensus motif; other site 511691005658 AMP binding site [chemical binding]; other site 511691005659 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 511691005660 Condensation domain; Region: Condensation; pfam00668 511691005661 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 511691005662 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 511691005663 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 511691005664 acyl-activating enzyme (AAE) consensus motif; other site 511691005665 AMP binding site [chemical binding]; other site 511691005666 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 511691005667 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511691005668 non-specific DNA binding site [nucleotide binding]; other site 511691005669 salt bridge; other site 511691005670 sequence-specific DNA binding site [nucleotide binding]; other site 511691005671 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 511691005672 nucleoside/Zn binding site; other site 511691005673 dimer interface [polypeptide binding]; other site 511691005674 catalytic motif [active] 511691005675 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 511691005676 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 511691005677 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 511691005678 putative active site [active] 511691005679 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 511691005680 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 511691005681 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 511691005682 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 511691005683 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 511691005684 DNA polymerase I; Provisional; Region: PRK05755 511691005685 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 511691005686 active site 511691005687 metal binding site 1 [ion binding]; metal-binding site 511691005688 putative 5' ssDNA interaction site; other site 511691005689 metal binding site 3; metal-binding site 511691005690 metal binding site 2 [ion binding]; metal-binding site 511691005691 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 511691005692 putative DNA binding site [nucleotide binding]; other site 511691005693 putative metal binding site [ion binding]; other site 511691005694 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 511691005695 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 511691005696 active site 511691005697 DNA binding site [nucleotide binding] 511691005698 catalytic site [active] 511691005699 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 511691005700 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 511691005701 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 511691005702 LytTr DNA-binding domain; Region: LytTR; pfam04397 511691005703 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 511691005704 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 511691005705 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 511691005706 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 511691005707 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 511691005708 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 511691005709 TPP-binding site [chemical binding]; other site 511691005710 dimer interface [polypeptide binding]; other site 511691005711 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 511691005712 PYR/PP interface [polypeptide binding]; other site 511691005713 dimer interface [polypeptide binding]; other site 511691005714 TPP binding site [chemical binding]; other site 511691005715 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 511691005716 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 511691005717 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 511691005718 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 511691005719 PRD domain; Region: PRD; pfam00874 511691005720 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 511691005721 active site 511691005722 P-loop; other site 511691005723 phosphorylation site [posttranslational modification] 511691005724 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 511691005725 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 511691005726 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 511691005727 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 511691005728 putative active site [active] 511691005729 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 511691005730 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511691005731 Walker A/P-loop; other site 511691005732 ATP binding site [chemical binding]; other site 511691005733 Q-loop/lid; other site 511691005734 ABC transporter signature motif; other site 511691005735 Walker B; other site 511691005736 D-loop; other site 511691005737 H-loop/switch region; other site 511691005738 L-ribulose-5-phosphate 4-epimerase; Provisional; Region: araD; PRK13145 511691005739 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 511691005740 intersubunit interface [polypeptide binding]; other site 511691005741 active site 511691005742 Zn2+ binding site [ion binding]; other site 511691005743 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 511691005744 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 511691005745 AP (apurinic/apyrimidinic) site pocket; other site 511691005746 DNA interaction; other site 511691005747 Metal-binding active site; metal-binding site 511691005748 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 511691005749 active site 511691005750 dimer interface [polypeptide binding]; other site 511691005751 magnesium binding site [ion binding]; other site 511691005752 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 511691005753 active site 511691005754 phosphorylation site [posttranslational modification] 511691005755 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 511691005756 active site 511691005757 P-loop; other site 511691005758 phosphorylation site [posttranslational modification] 511691005759 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 511691005760 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 511691005761 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 511691005762 GDP-binding site [chemical binding]; other site 511691005763 ACT binding site; other site 511691005764 IMP binding site; other site 511691005765 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 511691005766 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 511691005767 ATP-grasp domain; Region: ATP-grasp_4; cl17255 511691005768 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 511691005769 dimer interface [polypeptide binding]; other site 511691005770 FMN binding site [chemical binding]; other site 511691005771 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 511691005772 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 511691005773 Walker A/P-loop; other site 511691005774 ATP binding site [chemical binding]; other site 511691005775 Q-loop/lid; other site 511691005776 ABC transporter signature motif; other site 511691005777 Walker B; other site 511691005778 D-loop; other site 511691005779 H-loop/switch region; other site 511691005780 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 511691005781 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 511691005782 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 511691005783 Walker A/P-loop; other site 511691005784 ATP binding site [chemical binding]; other site 511691005785 Q-loop/lid; other site 511691005786 ABC transporter signature motif; other site 511691005787 Walker B; other site 511691005788 D-loop; other site 511691005789 H-loop/switch region; other site 511691005790 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 511691005791 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 511691005792 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 511691005793 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511691005794 dimer interface [polypeptide binding]; other site 511691005795 conserved gate region; other site 511691005796 putative PBP binding loops; other site 511691005797 ABC-ATPase subunit interface; other site 511691005798 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 511691005799 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511691005800 dimer interface [polypeptide binding]; other site 511691005801 conserved gate region; other site 511691005802 putative PBP binding loops; other site 511691005803 ABC-ATPase subunit interface; other site 511691005804 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 511691005805 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 511691005806 peptide binding site [polypeptide binding]; other site 511691005807 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 511691005808 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 511691005809 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 511691005810 FeS assembly protein SufB; Region: sufB; TIGR01980 511691005811 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 511691005812 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 511691005813 trimerization site [polypeptide binding]; other site 511691005814 active site 511691005815 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 511691005816 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 511691005817 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 511691005818 catalytic residue [active] 511691005819 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 511691005820 FeS assembly protein SufD; Region: sufD; TIGR01981 511691005821 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 511691005822 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 511691005823 Walker A/P-loop; other site 511691005824 ATP binding site [chemical binding]; other site 511691005825 Q-loop/lid; other site 511691005826 ABC transporter signature motif; other site 511691005827 Walker B; other site 511691005828 D-loop; other site 511691005829 H-loop/switch region; other site 511691005830 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 511691005831 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 511691005832 Mg++ binding site [ion binding]; other site 511691005833 putative catalytic motif [active] 511691005834 substrate binding site [chemical binding]; other site 511691005835 adaptor protein; Provisional; Region: PRK02315 511691005836 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 511691005837 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 511691005838 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 511691005839 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 511691005840 substrate binding pocket [chemical binding]; other site 511691005841 membrane-bound complex binding site; other site 511691005842 hinge residues; other site 511691005843 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511691005844 dimer interface [polypeptide binding]; other site 511691005845 conserved gate region; other site 511691005846 putative PBP binding loops; other site 511691005847 ABC-ATPase subunit interface; other site 511691005848 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 511691005849 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 511691005850 Walker A/P-loop; other site 511691005851 ATP binding site [chemical binding]; other site 511691005852 Q-loop/lid; other site 511691005853 ABC transporter signature motif; other site 511691005854 Walker B; other site 511691005855 D-loop; other site 511691005856 H-loop/switch region; other site 511691005857 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511691005858 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 511691005859 Walker A/P-loop; other site 511691005860 ATP binding site [chemical binding]; other site 511691005861 Q-loop/lid; other site 511691005862 ABC transporter signature motif; other site 511691005863 Walker B; other site 511691005864 D-loop; other site 511691005865 H-loop/switch region; other site 511691005866 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 511691005867 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 511691005868 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 511691005869 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 511691005870 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 511691005871 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 511691005872 threonine dehydratase; Validated; Region: PRK08639 511691005873 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 511691005874 tetramer interface [polypeptide binding]; other site 511691005875 pyridoxal 5'-phosphate binding site [chemical binding]; other site 511691005876 catalytic residue [active] 511691005877 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 511691005878 ketol-acid reductoisomerase; Provisional; Region: PRK05479 511691005879 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 511691005880 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 511691005881 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 511691005882 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 511691005883 putative valine binding site [chemical binding]; other site 511691005884 dimer interface [polypeptide binding]; other site 511691005885 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 511691005886 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07282 511691005887 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 511691005888 PYR/PP interface [polypeptide binding]; other site 511691005889 dimer interface [polypeptide binding]; other site 511691005890 TPP binding site [chemical binding]; other site 511691005891 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 511691005892 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 511691005893 TPP-binding site [chemical binding]; other site 511691005894 dimer interface [polypeptide binding]; other site 511691005895 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 511691005896 DAK2 domain; Region: Dak2; pfam02734 511691005897 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 511691005898 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 511691005899 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 511691005900 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 511691005901 phosphoglycolate phosphatase; Provisional; Region: PRK01158 511691005902 Domain of unknown function (DUF771); Region: DUF771; cl09962 511691005903 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 511691005904 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 511691005905 DNA binding site [nucleotide binding] 511691005906 active site 511691005907 Int/Topo IB signature motif; other site 511691005908 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 511691005909 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 511691005910 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 511691005911 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 511691005912 alphaNTD homodimer interface [polypeptide binding]; other site 511691005913 alphaNTD - beta interaction site [polypeptide binding]; other site 511691005914 alphaNTD - beta' interaction site [polypeptide binding]; other site 511691005915 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 511691005916 30S ribosomal protein S11; Validated; Region: PRK05309 511691005917 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 511691005918 30S ribosomal protein S13; Region: bact_S13; TIGR03631 511691005919 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 511691005920 rRNA binding site [nucleotide binding]; other site 511691005921 predicted 30S ribosome binding site; other site 511691005922 adenylate kinase; Reviewed; Region: adk; PRK00279 511691005923 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 511691005924 AMP-binding site [chemical binding]; other site 511691005925 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 511691005926 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 511691005927 SecY translocase; Region: SecY; pfam00344 511691005928 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 511691005929 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 511691005930 23S rRNA binding site [nucleotide binding]; other site 511691005931 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 511691005932 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 511691005933 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 511691005934 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 511691005935 5S rRNA interface [nucleotide binding]; other site 511691005936 L27 interface [polypeptide binding]; other site 511691005937 23S rRNA interface [nucleotide binding]; other site 511691005938 L5 interface [polypeptide binding]; other site 511691005939 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 511691005940 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 511691005941 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 511691005942 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 511691005943 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 511691005944 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 511691005945 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 511691005946 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 511691005947 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 511691005948 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 511691005949 RNA binding site [nucleotide binding]; other site 511691005950 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 511691005951 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 511691005952 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 511691005953 23S rRNA interface [nucleotide binding]; other site 511691005954 putative translocon interaction site; other site 511691005955 signal recognition particle (SRP54) interaction site; other site 511691005956 L23 interface [polypeptide binding]; other site 511691005957 trigger factor interaction site; other site 511691005958 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 511691005959 23S rRNA interface [nucleotide binding]; other site 511691005960 5S rRNA interface [nucleotide binding]; other site 511691005961 putative antibiotic binding site [chemical binding]; other site 511691005962 L25 interface [polypeptide binding]; other site 511691005963 L27 interface [polypeptide binding]; other site 511691005964 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 511691005965 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 511691005966 G-X-X-G motif; other site 511691005967 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 511691005968 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 511691005969 putative translocon binding site; other site 511691005970 protein-rRNA interface [nucleotide binding]; other site 511691005971 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 511691005972 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 511691005973 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 511691005974 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 511691005975 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 511691005976 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 511691005977 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 511691005978 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 511691005979 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511691005980 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 511691005981 non-specific DNA binding site [nucleotide binding]; other site 511691005982 salt bridge; other site 511691005983 sequence-specific DNA binding site [nucleotide binding]; other site 511691005984 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 511691005985 Catalytic site [active] 511691005986 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 511691005987 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 511691005988 active site 511691005989 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 511691005990 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511691005991 Walker A motif; other site 511691005992 ATP binding site [chemical binding]; other site 511691005993 Walker B motif; other site 511691005994 arginine finger; other site 511691005995 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511691005996 Walker A motif; other site 511691005997 ATP binding site [chemical binding]; other site 511691005998 Walker B motif; other site 511691005999 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 511691006000 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 511691006001 Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695 511691006002 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511691006003 Major Facilitator Superfamily; Region: MFS_1; pfam07690 511691006004 putative substrate translocation pore; other site 511691006005 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511691006006 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 511691006007 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 511691006008 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 511691006009 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 511691006010 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 511691006011 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 511691006012 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 511691006013 active site 511691006014 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 511691006015 Thioesterase domain; Region: Thioesterase; pfam00975 511691006016 Condensation domain; Region: Condensation; pfam00668 511691006017 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 511691006018 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 511691006019 acyl-activating enzyme (AAE) consensus motif; other site 511691006020 AMP binding site [chemical binding]; other site 511691006021 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 511691006022 Predicted nucleic-acid-binding protein containing a Zn-ribbon [General function prediction only]; Region: COG1545 511691006023 Rubredoxin-like zinc ribbon domain (DUF35_N); Region: DUF35_N; pfam12172 511691006024 acetyl-CoA acetyltransferase; Provisional; Region: PRK06064 511691006025 Thiolase domain associated with sterol carrier protein (SCP)-x isoform and related proteins; SCP-2 has multiple roles in intracellular lipid circulation and metabolism. The N-terminal presequence in the SCP-x isoform represents a peroxisomal...; Region: SCP-x_thiolase; cd00829 511691006026 active site 511691006027 hypothetical protein; Provisional; Region: PRK04262 511691006028 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 511691006029 dimer interface [polypeptide binding]; other site 511691006030 active site 511691006031 elongation factor Ts; Provisional; Region: tsf; PRK09377 511691006032 UBA/TS-N domain; Region: UBA; pfam00627 511691006033 Elongation factor TS; Region: EF_TS; pfam00889 511691006034 Elongation factor TS; Region: EF_TS; pfam00889 511691006035 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 511691006036 rRNA interaction site [nucleotide binding]; other site 511691006037 S8 interaction site; other site 511691006038 putative laminin-1 binding site; other site 511691006039 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 511691006040 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 511691006041 putative dimer interface [polypeptide binding]; other site 511691006042 catalytic triad [active] 511691006043 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 511691006044 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 511691006045 active site 511691006046 Zn binding site [ion binding]; other site 511691006047 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 511691006048 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 511691006049 Ca binding site [ion binding]; other site 511691006050 active site 511691006051 catalytic site [active] 511691006052 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 511691006053 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 511691006054 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 511691006055 active site turn [active] 511691006056 phosphorylation site [posttranslational modification] 511691006057 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 511691006058 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 511691006059 HPr interaction site; other site 511691006060 glycerol kinase (GK) interaction site [polypeptide binding]; other site 511691006061 active site 511691006062 phosphorylation site [posttranslational modification] 511691006063 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 511691006064 DNA-binding site [nucleotide binding]; DNA binding site 511691006065 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 511691006066 UTRA domain; Region: UTRA; pfam07702 511691006067 Glycosyl hydrolase family 66; Region: Glyco_hydro_66; pfam13199 511691006068 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 511691006069 putative active site [active] 511691006070 dimerization interface [polypeptide binding]; other site 511691006071 putative tRNAtyr binding site [nucleotide binding]; other site 511691006072 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 511691006073 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 511691006074 Zn2+ binding site [ion binding]; other site 511691006075 Mg2+ binding site [ion binding]; other site 511691006076 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 511691006077 synthetase active site [active] 511691006078 NTP binding site [chemical binding]; other site 511691006079 metal binding site [ion binding]; metal-binding site 511691006080 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 511691006081 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 511691006082 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 511691006083 putative catalytic site [active] 511691006084 putative metal binding site [ion binding]; other site 511691006085 putative phosphate binding site [ion binding]; other site 511691006086 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 511691006087 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 511691006088 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 511691006089 active site turn [active] 511691006090 phosphorylation site [posttranslational modification] 511691006091 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 511691006092 HPr interaction site; other site 511691006093 glycerol kinase (GK) interaction site [polypeptide binding]; other site 511691006094 active site 511691006095 phosphorylation site [posttranslational modification] 511691006096 Transcriptional regulators [Transcription]; Region: PurR; COG1609 511691006097 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 511691006098 DNA binding site [nucleotide binding] 511691006099 domain linker motif; other site 511691006100 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 511691006101 RNA methyltransferase, RsmE family; Region: TIGR00046 511691006102 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 511691006103 Methyltransferase domain; Region: Methyltransf_18; pfam12847 511691006104 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 511691006105 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 511691006106 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 511691006107 Coenzyme A binding pocket [chemical binding]; other site 511691006108 recombination factor protein RarA; Reviewed; Region: PRK13342 511691006109 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 511691006110 Walker A motif; other site 511691006111 ATP binding site [chemical binding]; other site 511691006112 Walker B motif; other site 511691006113 arginine finger; other site 511691006114 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 511691006115 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 511691006116 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 511691006117 Soluble P-type ATPase [General function prediction only]; Region: COG4087 511691006118 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 511691006119 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 511691006120 DNA binding residues [nucleotide binding] 511691006121 drug binding residues [chemical binding]; other site 511691006122 dimer interface [polypeptide binding]; other site 511691006123 Predicted membrane protein [Function unknown]; Region: COG2855 511691006124 Transcriptional regulator [Transcription]; Region: LysR; COG0583 511691006125 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 511691006126 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 511691006127 putative dimerization interface [polypeptide binding]; other site 511691006128 ferrochelatase; Reviewed; Region: hemH; PRK00035 511691006129 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 511691006130 C-terminal domain interface [polypeptide binding]; other site 511691006131 active site 511691006132 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 511691006133 active site 511691006134 N-terminal domain interface [polypeptide binding]; other site 511691006135 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 511691006136 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 511691006137 UDP-glucose 4-epimerase; Region: PLN02240 511691006138 NAD binding site [chemical binding]; other site 511691006139 homodimer interface [polypeptide binding]; other site 511691006140 active site 511691006141 substrate binding site [chemical binding]; other site 511691006142 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 511691006143 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 511691006144 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 511691006145 Ligand binding site; other site 511691006146 Putative Catalytic site; other site 511691006147 DXD motif; other site 511691006148 zinc transporter ZupT; Provisional; Region: PRK04201 511691006149 ZIP Zinc transporter; Region: Zip; pfam02535 511691006150 hypothetical protein; Validated; Region: PRK02101 511691006151 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 511691006152 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 511691006153 FeS/SAM binding site; other site 511691006154 Predicted acetyltransferase [General function prediction only]; Region: COG3981 511691006155 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 511691006156 Coenzyme A binding pocket [chemical binding]; other site 511691006157 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 511691006158 ATP cone domain; Region: ATP-cone; pfam03477 511691006159 Class III ribonucleotide reductase; Region: RNR_III; cd01675 511691006160 effector binding site; other site 511691006161 active site 511691006162 Zn binding site [ion binding]; other site 511691006163 glycine loop; other site 511691006164 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 511691006165 hypothetical protein; Provisional; Region: PRK13678 511691006166 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 511691006167 hypothetical protein; Provisional; Region: PRK05473 511691006168 LytTr DNA-binding domain; Region: LytTR; pfam04397 511691006169 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 511691006170 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 511691006171 ArsC family; Region: ArsC; pfam03960 511691006172 putative catalytic residues [active] 511691006173 thiol/disulfide switch; other site 511691006174 recombinase A; Provisional; Region: recA; PRK09354 511691006175 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 511691006176 hexamer interface [polypeptide binding]; other site 511691006177 Walker A motif; other site 511691006178 ATP binding site [chemical binding]; other site 511691006179 Walker B motif; other site 511691006180 competence damage-inducible protein A; Provisional; Region: PRK00549 511691006181 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 511691006182 putative MPT binding site; other site 511691006183 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 511691006184 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 511691006185 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 511691006186 RuvA N terminal domain; Region: RuvA_N; pfam01330 511691006187 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 511691006188 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 511691006189 ATP binding site [chemical binding]; other site 511691006190 Mg2+ binding site [ion binding]; other site 511691006191 G-X-G motif; other site 511691006192 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 511691006193 ATP binding site [chemical binding]; other site 511691006194 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 511691006195 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 511691006196 MutS domain I; Region: MutS_I; pfam01624 511691006197 MutS domain II; Region: MutS_II; pfam05188 511691006198 MutS domain III; Region: MutS_III; pfam05192 511691006199 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 511691006200 Walker A/P-loop; other site 511691006201 ATP binding site [chemical binding]; other site 511691006202 Q-loop/lid; other site 511691006203 ABC transporter signature motif; other site 511691006204 Walker B; other site 511691006205 D-loop; other site 511691006206 H-loop/switch region; other site 511691006207 Protein of unknown function (DUF964); Region: DUF964; cl01483 511691006208 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 511691006209 arginine repressor; Region: argR_whole; TIGR01529 511691006210 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 511691006211 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 511691006212 B3/4 domain; Region: B3_4; pfam03483 511691006213 Arginine repressor [Transcription]; Region: ArgR; COG1438 511691006214 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 511691006215 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 511691006216 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 511691006217 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 511691006218 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 511691006219 active site 511691006220 HIGH motif; other site 511691006221 KMSK motif region; other site 511691006222 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 511691006223 tRNA binding surface [nucleotide binding]; other site 511691006224 anticodon binding site; other site 511691006225 Uncharacterized conserved protein [Function unknown]; Region: COG1284 511691006226 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 511691006227 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 511691006228 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 511691006229 Uncharacterized conserved protein [Function unknown]; Region: COG1284 511691006230 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 511691006231 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 511691006232 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 511691006233 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 511691006234 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 511691006235 dimer interface [polypeptide binding]; other site 511691006236 anticodon binding site; other site 511691006237 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 511691006238 homodimer interface [polypeptide binding]; other site 511691006239 motif 1; other site 511691006240 active site 511691006241 motif 2; other site 511691006242 GAD domain; Region: GAD; pfam02938 511691006243 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 511691006244 motif 3; other site 511691006245 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 511691006246 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 511691006247 dimer interface [polypeptide binding]; other site 511691006248 motif 1; other site 511691006249 active site 511691006250 motif 2; other site 511691006251 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 511691006252 anticodon binding site; other site 511691006253 Amino acid permease; Region: AA_permease_2; pfam13520 511691006254 ISSdy1 fragment 511691006255 IS861 fragment 511691006256 IS862 fragment 511691006257 IS863 fragment 511691006258 ISSpn1 511691006259 Integrase core domain; Region: rve; pfam00665 511691006260 IS861 fragment 511691006261 IS861 fragment 511691006262 IS861 fragment 511691006263 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 511691006264 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 511691006265 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 511691006266 FtsX-like permease family; Region: FtsX; pfam02687 511691006267 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 511691006268 dimerization interface [polypeptide binding]; other site 511691006269 putative DNA binding site [nucleotide binding]; other site 511691006270 putative Zn2+ binding site [ion binding]; other site 511691006271 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 511691006272 putative substrate translocation pore; other site 511691006273 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 511691006274 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 511691006275 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 511691006276 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 511691006277 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 511691006278 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 511691006279 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 511691006280 catalytic core [active] 511691006281 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 511691006282 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 511691006283 DNA binding residues [nucleotide binding] 511691006284 putative dimer interface [polypeptide binding]; other site 511691006285 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 511691006286 classical (c) SDRs; Region: SDR_c; cd05233 511691006287 NAD(P) binding site [chemical binding]; other site 511691006288 active site 511691006289 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 511691006290 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 511691006291 Walker A/P-loop; other site 511691006292 ATP binding site [chemical binding]; other site 511691006293 Q-loop/lid; other site 511691006294 ABC transporter signature motif; other site 511691006295 Walker B; other site 511691006296 D-loop; other site 511691006297 H-loop/switch region; other site 511691006298 FOG: CBS domain [General function prediction only]; Region: COG0517 511691006299 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 511691006300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511691006301 dimer interface [polypeptide binding]; other site 511691006302 conserved gate region; other site 511691006303 putative PBP binding loops; other site 511691006304 ABC-ATPase subunit interface; other site 511691006305 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 511691006306 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 511691006307 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 511691006308 dimer interface [polypeptide binding]; other site 511691006309 conserved gate region; other site 511691006310 ABC-ATPase subunit interface; other site 511691006311 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 511691006312 active site 511691006313 DNA binding site [nucleotide binding] 511691006314 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350 511691006315 Predicted transcriptional regulators [Transcription]; Region: COG1733 511691006316 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 511691006317 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 511691006318 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 511691006319 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 511691006320 NAD(P) binding site [chemical binding]; other site 511691006321 catalytic residues [active] 511691006322 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 511691006323 Domain of unknown function DUF59; Region: DUF59; cl00941 511691006324 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 511691006325 gating phenylalanine in ion channel; other site 511691006326 Predicted membrane protein [Function unknown]; Region: COG1511 511691006327 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 511691006328 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 511691006329 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 511691006330 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 511691006331 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 511691006332 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 511691006333 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 511691006334 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 511691006335 RNA binding surface [nucleotide binding]; other site 511691006336 Uncharacterized protein conserved in bacteria [Function unknown]; Region: Veg; COG4466 511691006337 replicative DNA helicase; Provisional; Region: PRK05748 511691006338 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 511691006339 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 511691006340 Walker A motif; other site 511691006341 ATP binding site [chemical binding]; other site 511691006342 Walker B motif; other site 511691006343 DNA binding loops [nucleotide binding] 511691006344 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 511691006345 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 511691006346 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 511691006347 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 511691006348 DHH family; Region: DHH; pfam01368 511691006349 DHHA1 domain; Region: DHHA1; pfam02272 511691006350 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 511691006351 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 511691006352 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 511691006353 hypothetical protein; Provisional; Region: PRK09273 511691006354 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 511691006355 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 511691006356 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 511691006357 IS861 fragment 511691006358 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 511691006359 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 511691006360 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 511691006361 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13649 511691006362 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 511691006363 Walker A/P-loop; other site 511691006364 ATP binding site [chemical binding]; other site 511691006365 Q-loop/lid; other site 511691006366 ABC transporter signature motif; other site 511691006367 Walker B; other site 511691006368 D-loop; other site 511691006369 H-loop/switch region; other site 511691006370 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13650 511691006371 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 511691006372 Walker A/P-loop; other site 511691006373 ATP binding site [chemical binding]; other site 511691006374 Q-loop/lid; other site 511691006375 ABC transporter signature motif; other site 511691006376 Walker B; other site 511691006377 D-loop; other site 511691006378 H-loop/switch region; other site 511691006379 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 511691006380 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 511691006381 non-specific DNA binding site [nucleotide binding]; other site 511691006382 salt bridge; other site 511691006383 sequence-specific DNA binding site [nucleotide binding]; other site 511691006384 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 511691006385 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 511691006386 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 511691006387 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 511691006388 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 511691006389 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 511691006390 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 511691006391 recombination protein F; Reviewed; Region: recF; PRK00064 511691006392 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 511691006393 Walker A/P-loop; other site 511691006394 ATP binding site [chemical binding]; other site 511691006395 Q-loop/lid; other site 511691006396 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511691006397 ABC transporter signature motif; other site 511691006398 Walker B; other site 511691006399 D-loop; other site 511691006400 H-loop/switch region; other site 511691006401 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 511691006402 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 511691006403 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 511691006404 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 511691006405 active site 511691006406 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 511691006407 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 511691006408 active site 511691006409 HIGH motif; other site 511691006410 dimer interface [polypeptide binding]; other site 511691006411 KMSKS motif; other site 511691006412 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 511691006413 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 511691006414 Walker A/P-loop; other site 511691006415 ATP binding site [chemical binding]; other site 511691006416 Q-loop/lid; other site 511691006417 ABC transporter signature motif; other site 511691006418 Walker B; other site 511691006419 D-loop; other site 511691006420 H-loop/switch region; other site 511691006421 ABC transporter; Region: ABC_tran_2; pfam12848 511691006422 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 511691006423 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 511691006424 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 511691006425 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 511691006426 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 511691006427 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 511691006428 protein binding site [polypeptide binding]; other site 511691006429 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 511691006430 ParB-like nuclease domain; Region: ParBc; pfam02195 511691006431 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775