-- dump date 20140620_083145 -- class Genbank::misc_feature -- table misc_feature_note -- id note 210007000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 210007000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 210007000003 Walker A motif; other site 210007000004 ATP binding site [chemical binding]; other site 210007000005 Walker B motif; other site 210007000006 arginine finger; other site 210007000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 210007000008 DnaA box-binding interface [nucleotide binding]; other site 210007000009 DNA polymerase III subunit beta; Validated; Region: PRK05643 210007000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 210007000011 putative DNA binding surface [nucleotide binding]; other site 210007000012 dimer interface [polypeptide binding]; other site 210007000013 beta-clamp/clamp loader binding surface; other site 210007000014 beta-clamp/translesion DNA polymerase binding surface; other site 210007000015 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 210007000016 GTP-binding protein YchF; Reviewed; Region: PRK09601 210007000017 YchF GTPase; Region: YchF; cd01900 210007000018 G1 box; other site 210007000019 GTP/Mg2+ binding site [chemical binding]; other site 210007000020 Switch I region; other site 210007000021 G2 box; other site 210007000022 Switch II region; other site 210007000023 G3 box; other site 210007000024 G4 box; other site 210007000025 G5 box; other site 210007000026 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 210007000027 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 210007000028 putative active site [active] 210007000029 catalytic residue [active] 210007000030 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 210007000031 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 210007000032 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 210007000033 ATP binding site [chemical binding]; other site 210007000034 putative Mg++ binding site [ion binding]; other site 210007000035 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 210007000036 nucleotide binding region [chemical binding]; other site 210007000037 ATP-binding site [chemical binding]; other site 210007000038 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 210007000039 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 210007000040 RNA binding surface [nucleotide binding]; other site 210007000041 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 210007000042 Septum formation initiator; Region: DivIC; pfam04977 210007000043 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 210007000044 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 210007000045 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 210007000046 Ligand Binding Site [chemical binding]; other site 210007000047 TilS substrate C-terminal domain; Region: TilS_C; smart00977 210007000048 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 210007000049 active site 210007000050 FtsH Extracellular; Region: FtsH_ext; pfam06480 210007000051 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 210007000052 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 210007000053 Walker A motif; other site 210007000054 ATP binding site [chemical binding]; other site 210007000055 Walker B motif; other site 210007000056 arginine finger; other site 210007000057 Peptidase family M41; Region: Peptidase_M41; pfam01434 210007000058 amino acid transporter; Region: 2A0306; TIGR00909 210007000059 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 210007000060 rod shape-determining protein MreC; Provisional; Region: PRK13922 210007000061 rod shape-determining protein MreC; Region: MreC; pfam04085 210007000062 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 210007000063 Surface antigen [General function prediction only]; Region: COG3942 210007000064 CHAP domain; Region: CHAP; pfam05257 210007000065 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269 210007000066 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 210007000067 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 210007000068 active site 210007000069 aromatic amino acid aminotransferase; Validated; Region: PRK07309 210007000070 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 210007000071 pyridoxal 5'-phosphate binding site [chemical binding]; other site 210007000072 homodimer interface [polypeptide binding]; other site 210007000073 catalytic residue [active] 210007000074 Recombination protein O N terminal; Region: RecO_N; pfam11967 210007000075 DNA repair protein RecO; Region: reco; TIGR00613 210007000076 Recombination protein O C terminal; Region: RecO_C; pfam02565 210007000077 putative phosphate acyltransferase; Provisional; Region: PRK05331 210007000078 acyl carrier protein; Provisional; Region: PRK12449 210007000079 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 210007000080 Walker A/P-loop; other site 210007000081 ATP binding site [chemical binding]; other site 210007000082 ABC transporter; Region: ABC_tran; pfam00005 210007000083 Q-loop/lid; other site 210007000084 ABC transporter signature motif; other site 210007000085 Walker B; other site 210007000086 D-loop; other site 210007000087 H-loop/switch region; other site 210007000088 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 210007000089 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 210007000090 ATP binding site [chemical binding]; other site 210007000091 active site 210007000092 substrate binding site [chemical binding]; other site 210007000093 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 210007000094 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 210007000095 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 210007000096 dimerization interface [polypeptide binding]; other site 210007000097 ATP binding site [chemical binding]; other site 210007000098 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 210007000099 dimerization interface [polypeptide binding]; other site 210007000100 ATP binding site [chemical binding]; other site 210007000101 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 210007000102 putative active site [active] 210007000103 catalytic triad [active] 210007000104 A new structural DNA glycosylase; Region: AlkD_like; cl11434 210007000105 HEAT repeats; Region: HEAT_2; pfam13646 210007000106 active site 210007000107 amidophosphoribosyltransferase; Provisional; Region: PRK07272 210007000108 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 210007000109 active site 210007000110 tetramer interface [polypeptide binding]; other site 210007000111 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 210007000112 active site 210007000113 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 210007000114 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 210007000115 dimerization interface [polypeptide binding]; other site 210007000116 putative ATP binding site [chemical binding]; other site 210007000117 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 210007000118 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 210007000119 active site 210007000120 substrate binding site [chemical binding]; other site 210007000121 cosubstrate binding site; other site 210007000122 catalytic site [active] 210007000123 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 210007000124 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 210007000125 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 210007000126 purine monophosphate binding site [chemical binding]; other site 210007000127 dimer interface [polypeptide binding]; other site 210007000128 putative catalytic residues [active] 210007000129 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 210007000130 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 210007000131 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 210007000132 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 210007000133 hypothetical protein; Provisional; Region: PHA03335 210007000134 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 210007000135 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 210007000136 Abi-like protein; Region: Abi_2; pfam07751 210007000137 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 210007000138 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589 210007000139 Mg2+ binding site [ion binding]; other site 210007000140 G-X-G motif; other site 210007000141 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 210007000142 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 210007000143 ATP binding site [chemical binding]; other site 210007000144 Mg2+ binding site [ion binding]; other site 210007000145 G-X-G motif; other site 210007000146 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 210007000147 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 210007000148 active site 210007000149 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 210007000150 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 210007000151 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 210007000152 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 210007000153 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 210007000154 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 210007000155 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 210007000156 ATP-grasp domain; Region: ATP-grasp; pfam02222 210007000157 aspartate racemase; Region: asp_race; TIGR00035 210007000158 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 210007000159 adenylosuccinate lyase; Provisional; Region: PRK07492 210007000160 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 210007000161 tetramer interface [polypeptide binding]; other site 210007000162 active site 210007000163 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 210007000164 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 210007000165 active site 210007000166 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 210007000167 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 210007000168 non-specific DNA binding site [nucleotide binding]; other site 210007000169 salt bridge; other site 210007000170 sequence-specific DNA binding site [nucleotide binding]; other site 210007000171 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 210007000172 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 210007000173 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 210007000174 Walker A motif; other site 210007000175 ATP binding site [chemical binding]; other site 210007000176 Walker B motif; other site 210007000177 arginine finger; other site 210007000178 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 210007000179 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 210007000180 Low molecular weight phosphatase family; Region: LMWPc; cd00115 210007000181 active site 210007000182 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 210007000183 Acyltransferase family; Region: Acyl_transf_3; pfam01757 210007000184 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 210007000185 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 210007000186 catalytic triad [active] 210007000187 catalytic triad [active] 210007000188 oxyanion hole [active] 210007000189 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 210007000190 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 210007000191 pyridoxal 5'-phosphate binding site [chemical binding]; other site 210007000192 catalytic residue [active] 210007000193 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 210007000194 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 210007000195 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 210007000196 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 210007000197 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 210007000198 catalytic core [active] 210007000199 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 210007000200 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 210007000201 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 210007000202 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 210007000203 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 210007000204 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 210007000205 Cadherin-like beta sandwich domain; Region: Cadherin-like; pfam12733 210007000206 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 210007000207 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 210007000208 substrate binding [chemical binding]; other site 210007000209 active site 210007000210 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 210007000211 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 210007000212 Laminin G domain; Region: Laminin_G_2; pfam02210 210007000213 Glycosyl hydrolases family 32; Region: Glyco_32; smart00640 210007000214 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 210007000215 substrate binding [chemical binding]; other site 210007000216 active site 210007000217 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 210007000218 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 210007000219 GrpE; Region: GrpE; pfam01025 210007000220 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 210007000221 dimer interface [polypeptide binding]; other site 210007000222 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 210007000223 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 210007000224 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 210007000225 nucleotide binding site [chemical binding]; other site 210007000226 NEF interaction site [polypeptide binding]; other site 210007000227 SBD interface [polypeptide binding]; other site 210007000228 chaperone protein DnaJ; Provisional; Region: PRK14276 210007000229 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 210007000230 HSP70 interaction site [polypeptide binding]; other site 210007000231 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 210007000232 substrate binding site [polypeptide binding]; other site 210007000233 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 210007000234 Zn binding sites [ion binding]; other site 210007000235 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 210007000236 dimer interface [polypeptide binding]; other site 210007000237 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 210007000238 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 210007000239 dimerization interface 3.5A [polypeptide binding]; other site 210007000240 active site 210007000241 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 210007000242 dimer interface [polypeptide binding]; other site 210007000243 substrate binding site [chemical binding]; other site 210007000244 ATP binding site [chemical binding]; other site 210007000245 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 210007000246 hypothetical protein; Provisional; Region: PRK13690 210007000247 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 210007000248 Mechanosensitive ion channel; Region: MS_channel; pfam00924 210007000249 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 210007000250 trigger factor; Provisional; Region: tig; PRK01490 210007000251 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 210007000252 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 210007000253 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 210007000254 CTP synthetase; Validated; Region: pyrG; PRK05380 210007000255 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 210007000256 Catalytic site [active] 210007000257 active site 210007000258 UTP binding site [chemical binding]; other site 210007000259 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 210007000260 active site 210007000261 putative oxyanion hole; other site 210007000262 catalytic triad [active] 210007000263 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 210007000264 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 210007000265 intersubunit interface [polypeptide binding]; other site 210007000266 active site 210007000267 zinc binding site [ion binding]; other site 210007000268 Na+ binding site [ion binding]; other site 210007000269 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 210007000270 active site 210007000271 phosphorylation site [posttranslational modification] 210007000272 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 210007000273 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 210007000274 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 210007000275 active pocket/dimerization site; other site 210007000276 active site 210007000277 phosphorylation site [posttranslational modification] 210007000278 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 210007000279 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 210007000280 putative active site [active] 210007000281 putative catalytic site [active] 210007000282 Transcriptional regulators [Transcription]; Region: PurR; COG1609 210007000283 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 210007000284 DNA binding site [nucleotide binding] 210007000285 domain linker motif; other site 210007000286 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 210007000287 dimerization interface [polypeptide binding]; other site 210007000288 ligand binding site [chemical binding]; other site 210007000289 sodium binding site [ion binding]; other site 210007000290 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 210007000291 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 210007000292 S-adenosylmethionine binding site [chemical binding]; other site 210007000293 H+ Antiporter protein; Region: 2A0121; TIGR00900 210007000294 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 210007000295 non-specific DNA binding site [nucleotide binding]; other site 210007000296 salt bridge; other site 210007000297 sequence-specific DNA binding site [nucleotide binding]; other site 210007000298 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 210007000299 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 210007000300 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 210007000301 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 210007000302 putative active site [active] 210007000303 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 210007000304 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 210007000305 putative substrate binding site [chemical binding]; other site 210007000306 putative ATP binding site [chemical binding]; other site 210007000307 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 210007000308 active site 210007000309 P-loop; other site 210007000310 phosphorylation site [posttranslational modification] 210007000311 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 210007000312 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 210007000313 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 210007000314 active site 210007000315 phosphorylation site [posttranslational modification] 210007000316 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK04161 210007000317 S-formylglutathione hydrolase; Region: PLN02442 210007000318 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 210007000319 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 210007000320 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 210007000321 substrate binding site [chemical binding]; other site 210007000322 catalytic Zn binding site [ion binding]; other site 210007000323 NAD binding site [chemical binding]; other site 210007000324 structural Zn binding site [ion binding]; other site 210007000325 dimer interface [polypeptide binding]; other site 210007000326 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 210007000327 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 210007000328 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 210007000329 DNA polymerase III PolC; Validated; Region: polC; PRK00448 210007000330 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 210007000331 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 210007000332 generic binding surface II; other site 210007000333 generic binding surface I; other site 210007000334 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 210007000335 active site 210007000336 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 210007000337 active site 210007000338 catalytic site [active] 210007000339 substrate binding site [chemical binding]; other site 210007000340 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 210007000341 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 210007000342 MarR family; Region: MarR; pfam01047 210007000343 Predicted flavoprotein [General function prediction only]; Region: COG0431 210007000344 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 210007000345 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 210007000346 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 210007000347 tetramer interface [polypeptide binding]; other site 210007000348 TPP-binding site [chemical binding]; other site 210007000349 heterodimer interface [polypeptide binding]; other site 210007000350 phosphorylation loop region [posttranslational modification] 210007000351 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 210007000352 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 210007000353 alpha subunit interface [polypeptide binding]; other site 210007000354 TPP binding site [chemical binding]; other site 210007000355 heterodimer interface [polypeptide binding]; other site 210007000356 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 210007000357 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 210007000358 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 210007000359 E3 interaction surface; other site 210007000360 lipoyl attachment site [posttranslational modification]; other site 210007000361 e3 binding domain; Region: E3_binding; pfam02817 210007000362 e3 binding domain; Region: E3_binding; pfam02817 210007000363 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 210007000364 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 210007000365 E3 interaction surface; other site 210007000366 lipoyl attachment site [posttranslational modification]; other site 210007000367 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 210007000368 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 210007000369 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 210007000370 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 210007000371 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 210007000372 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 210007000373 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 210007000374 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 210007000375 metal binding site [ion binding]; metal-binding site 210007000376 dimer interface [polypeptide binding]; other site 210007000377 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 210007000378 Major Facilitator Superfamily; Region: MFS_1; pfam07690 210007000379 putative substrate translocation pore; other site 210007000380 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 210007000381 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 210007000382 Transcriptional regulator [Transcription]; Region: LysR; COG0583 210007000383 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 210007000384 The substrate binding domain of LysR-type transcriptional regulator MleR which required for malolactic fermentation, contains type 2 periplasmic binidning fold; Region: PBP2_MleR; cd08437 210007000385 putative dimerization interface [polypeptide binding]; other site 210007000386 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 210007000387 non-specific DNA binding site [nucleotide binding]; other site 210007000388 salt bridge; other site 210007000389 sequence-specific DNA binding site [nucleotide binding]; other site 210007000390 malate dehydrogenase; Provisional; Region: PRK13529 210007000391 Malic enzyme, N-terminal domain; Region: malic; pfam00390 210007000392 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 210007000393 NAD(P) binding site [chemical binding]; other site 210007000394 Membrane transport protein; Region: Mem_trans; cl09117 210007000395 bicupin, oxalate decarboxylase family; Region: bicupin_oxalic; TIGR03404 210007000396 Cupin; Region: Cupin_1; smart00835 210007000397 Cupin; Region: Cupin_1; smart00835 210007000398 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 210007000399 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 210007000400 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 210007000401 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 210007000402 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 210007000403 active site 210007000404 catalytic residues [active] 210007000405 metal binding site [ion binding]; metal-binding site 210007000406 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 210007000407 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 210007000408 ligand binding site [chemical binding]; other site 210007000409 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 210007000410 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 210007000411 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 210007000412 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 210007000413 putative catalytic cysteine [active] 210007000414 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 210007000415 putative active site [active] 210007000416 metal binding site [ion binding]; metal-binding site 210007000417 Transposase IS200 like; Region: Y1_Tnp; pfam01797 210007000418 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 210007000419 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 210007000420 16S/18S rRNA binding site [nucleotide binding]; other site 210007000421 S13e-L30e interaction site [polypeptide binding]; other site 210007000422 25S rRNA binding site [nucleotide binding]; other site 210007000423 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 210007000424 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 210007000425 RNase E interface [polypeptide binding]; other site 210007000426 trimer interface [polypeptide binding]; other site 210007000427 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 210007000428 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 210007000429 RNase E interface [polypeptide binding]; other site 210007000430 trimer interface [polypeptide binding]; other site 210007000431 active site 210007000432 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 210007000433 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 210007000434 RNA binding site [nucleotide binding]; other site 210007000435 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 210007000436 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 210007000437 trimer interface [polypeptide binding]; other site 210007000438 active site 210007000439 substrate binding site [chemical binding]; other site 210007000440 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 210007000441 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 210007000442 active site 210007000443 HIGH motif; other site 210007000444 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 210007000445 KMSKS motif; other site 210007000446 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 210007000447 tRNA binding surface [nucleotide binding]; other site 210007000448 anticodon binding site; other site 210007000449 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 210007000450 active site 210007000451 metal binding site [ion binding]; metal-binding site 210007000452 dimerization interface [polypeptide binding]; other site 210007000453 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 210007000454 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 210007000455 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 210007000456 DNA binding residues [nucleotide binding] 210007000457 dimer interface [polypeptide binding]; other site 210007000458 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 210007000459 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 210007000460 Predicted transcriptional regulators [Transcription]; Region: COG1695 210007000461 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 210007000462 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 210007000463 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 210007000464 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 210007000465 EDD domain protein, DegV family; Region: DegV; TIGR00762 210007000466 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 210007000467 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 210007000468 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 210007000469 non-specific DNA binding site [nucleotide binding]; other site 210007000470 salt bridge; other site 210007000471 sequence-specific DNA binding site [nucleotide binding]; other site 210007000472 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 210007000473 23S rRNA interface [nucleotide binding]; other site 210007000474 L3 interface [polypeptide binding]; other site 210007000475 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 210007000476 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 210007000477 PemK-like protein; Region: PemK; pfam02452 210007000478 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 210007000479 active site 210007000480 NTP binding site [chemical binding]; other site 210007000481 metal binding triad [ion binding]; metal-binding site 210007000482 antibiotic binding site [chemical binding]; other site 210007000483 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 210007000484 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 210007000485 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 210007000486 PGAP1-like protein; Region: PGAP1; pfam07819 210007000487 Predicted flavoprotein [General function prediction only]; Region: COG0431 210007000488 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 210007000489 Predicted flavoprotein [General function prediction only]; Region: COG0431 210007000490 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 210007000491 FMN-binding domain; Region: FMN_bind; cl01081 210007000492 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 210007000493 L-aspartate oxidase; Provisional; Region: PRK06175 210007000494 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 210007000495 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 210007000496 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 210007000497 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 210007000498 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 210007000499 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 210007000500 ABC-ATPase subunit interface; other site 210007000501 dimer interface [polypeptide binding]; other site 210007000502 putative PBP binding regions; other site 210007000503 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 210007000504 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 210007000505 metal binding site [ion binding]; metal-binding site 210007000506 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 210007000507 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 210007000508 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 210007000509 FeoA domain; Region: FeoA; pfam04023 210007000510 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 210007000511 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 210007000512 FMN binding site [chemical binding]; other site 210007000513 active site 210007000514 catalytic residues [active] 210007000515 substrate binding site [chemical binding]; other site 210007000516 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 210007000517 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 210007000518 dimerization interface [polypeptide binding]; other site 210007000519 domain crossover interface; other site 210007000520 redox-dependent activation switch; other site 210007000521 integrase; Provisional; Region: int; PHA02601 210007000522 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 210007000523 Int/Topo IB signature motif; other site 210007000524 Domain of unknown function (DUF3173); Region: DUF3173; pfam11372 210007000525 Domain of Unknown Function with PDB structure (DUF3850); Region: DUF3850; pfam12961 210007000526 CHAP domain; Region: CHAP; pfam05257 210007000527 Fez1; Region: Fez1; pfam06818 210007000528 AAA-like domain; Region: AAA_10; pfam12846 210007000529 TcpE family; Region: TcpE; pfam12648 210007000530 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 210007000531 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 210007000532 non-specific DNA binding site [nucleotide binding]; other site 210007000533 salt bridge; other site 210007000534 sequence-specific DNA binding site [nucleotide binding]; other site 210007000535 Replication initiation factor; Region: Rep_trans; pfam02486 210007000536 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 210007000537 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 210007000538 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 210007000539 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 210007000540 non-specific DNA binding site [nucleotide binding]; other site 210007000541 salt bridge; other site 210007000542 sequence-specific DNA binding site [nucleotide binding]; other site 210007000543 Domain of unknown function (DUF955); Region: DUF955; pfam06114 210007000544 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 210007000545 Int/Topo IB signature motif; other site 210007000546 Domain of unknown function (DUF771); Region: DUF771; cl09962 210007000547 phosphoglycolate phosphatase; Provisional; Region: PRK01158 210007000548 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 210007000549 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 210007000550 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 210007000551 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 210007000552 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 210007000553 DAK2 domain; Region: Dak2; pfam02734 210007000554 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07282 210007000555 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 210007000556 PYR/PP interface [polypeptide binding]; other site 210007000557 dimer interface [polypeptide binding]; other site 210007000558 TPP binding site [chemical binding]; other site 210007000559 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 210007000560 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 210007000561 TPP-binding site [chemical binding]; other site 210007000562 dimer interface [polypeptide binding]; other site 210007000563 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 210007000564 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 210007000565 putative valine binding site [chemical binding]; other site 210007000566 dimer interface [polypeptide binding]; other site 210007000567 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 210007000568 ketol-acid reductoisomerase; Provisional; Region: PRK05479 210007000569 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 210007000570 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 210007000571 threonine dehydratase; Validated; Region: PRK08639 210007000572 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 210007000573 tetramer interface [polypeptide binding]; other site 210007000574 pyridoxal 5'-phosphate binding site [chemical binding]; other site 210007000575 catalytic residue [active] 210007000576 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 210007000577 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 210007000578 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 210007000579 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 210007000580 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 210007000581 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 210007000582 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 210007000583 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 210007000584 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 210007000585 Walker A/P-loop; other site 210007000586 ATP binding site [chemical binding]; other site 210007000587 Q-loop/lid; other site 210007000588 ABC transporter signature motif; other site 210007000589 Walker B; other site 210007000590 D-loop; other site 210007000591 H-loop/switch region; other site 210007000592 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 210007000593 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 210007000594 Walker A/P-loop; other site 210007000595 ATP binding site [chemical binding]; other site 210007000596 Q-loop/lid; other site 210007000597 ABC transporter signature motif; other site 210007000598 Walker B; other site 210007000599 D-loop; other site 210007000600 H-loop/switch region; other site 210007000601 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 210007000602 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 210007000603 substrate binding pocket [chemical binding]; other site 210007000604 membrane-bound complex binding site; other site 210007000605 hinge residues; other site 210007000606 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 210007000607 dimer interface [polypeptide binding]; other site 210007000608 conserved gate region; other site 210007000609 putative PBP binding loops; other site 210007000610 ABC-ATPase subunit interface; other site 210007000611 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 210007000612 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 210007000613 adaptor protein; Provisional; Region: PRK02315 210007000614 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 210007000615 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 210007000616 Mg++ binding site [ion binding]; other site 210007000617 putative catalytic motif [active] 210007000618 substrate binding site [chemical binding]; other site 210007000619 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 210007000620 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 210007000621 Walker A/P-loop; other site 210007000622 ATP binding site [chemical binding]; other site 210007000623 Q-loop/lid; other site 210007000624 ABC transporter signature motif; other site 210007000625 Walker B; other site 210007000626 D-loop; other site 210007000627 H-loop/switch region; other site 210007000628 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 210007000629 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 210007000630 FeS assembly protein SufD; Region: sufD; TIGR01981 210007000631 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 210007000632 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 210007000633 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 210007000634 catalytic residue [active] 210007000635 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 210007000636 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 210007000637 trimerization site [polypeptide binding]; other site 210007000638 active site 210007000639 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 210007000640 FeS assembly protein SufB; Region: sufB; TIGR01980 210007000641 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 210007000642 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 210007000643 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 210007000644 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 210007000645 peptide binding site [polypeptide binding]; other site 210007000646 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 210007000647 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 210007000648 dimer interface [polypeptide binding]; other site 210007000649 conserved gate region; other site 210007000650 putative PBP binding loops; other site 210007000651 ABC-ATPase subunit interface; other site 210007000652 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 210007000653 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 210007000654 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 210007000655 dimer interface [polypeptide binding]; other site 210007000656 conserved gate region; other site 210007000657 putative PBP binding loops; other site 210007000658 ABC-ATPase subunit interface; other site 210007000659 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 210007000660 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 210007000661 Walker A/P-loop; other site 210007000662 ATP binding site [chemical binding]; other site 210007000663 Q-loop/lid; other site 210007000664 ABC transporter signature motif; other site 210007000665 Walker B; other site 210007000666 D-loop; other site 210007000667 H-loop/switch region; other site 210007000668 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 210007000669 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 210007000670 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 210007000671 Walker A/P-loop; other site 210007000672 ATP binding site [chemical binding]; other site 210007000673 Q-loop/lid; other site 210007000674 ABC transporter signature motif; other site 210007000675 Walker B; other site 210007000676 D-loop; other site 210007000677 H-loop/switch region; other site 210007000678 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 210007000679 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 210007000680 dimer interface [polypeptide binding]; other site 210007000681 FMN binding site [chemical binding]; other site 210007000682 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 210007000683 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 210007000684 DNA binding residues [nucleotide binding] 210007000685 dimerization interface [polypeptide binding]; other site 210007000686 putrescine carbamoyltransferase; Provisional; Region: PRK02255 210007000687 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 210007000688 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 210007000689 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 210007000690 agmatine deiminase; Provisional; Region: PRK13551 210007000691 agmatine deiminase; Region: agmatine_aguA; TIGR03380 210007000692 carbamate kinase; Reviewed; Region: PRK12686 210007000693 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 210007000694 putative substrate binding site [chemical binding]; other site 210007000695 nucleotide binding site [chemical binding]; other site 210007000696 nucleotide binding site [chemical binding]; other site 210007000697 homodimer interface [polypeptide binding]; other site 210007000698 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 210007000699 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 210007000700 ATP-grasp domain; Region: ATP-grasp_4; cl17255 210007000701 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 210007000702 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 210007000703 GDP-binding site [chemical binding]; other site 210007000704 ACT binding site; other site 210007000705 IMP binding site; other site 210007000706 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 210007000707 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 210007000708 active site 210007000709 P-loop; other site 210007000710 phosphorylation site [posttranslational modification] 210007000711 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 210007000712 active site 210007000713 phosphorylation site [posttranslational modification] 210007000714 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 210007000715 active site 210007000716 dimer interface [polypeptide binding]; other site 210007000717 magnesium binding site [ion binding]; other site 210007000718 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 210007000719 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 210007000720 AP (apurinic/apyrimidinic) site pocket; other site 210007000721 DNA interaction; other site 210007000722 Metal-binding active site; metal-binding site 210007000723 L-ribulose-5-phosphate 4-epimerase; Provisional; Region: araD; PRK13145 210007000724 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 210007000725 intersubunit interface [polypeptide binding]; other site 210007000726 active site 210007000727 Zn2+ binding site [ion binding]; other site 210007000728 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 210007000729 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 210007000730 putative active site [active] 210007000731 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 210007000732 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 210007000733 Walker A/P-loop; other site 210007000734 ATP binding site [chemical binding]; other site 210007000735 Q-loop/lid; other site 210007000736 ABC transporter signature motif; other site 210007000737 Walker B; other site 210007000738 D-loop; other site 210007000739 H-loop/switch region; other site 210007000740 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 210007000741 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 210007000742 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 210007000743 PRD domain; Region: PRD; pfam00874 210007000744 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 210007000745 active site 210007000746 P-loop; other site 210007000747 phosphorylation site [posttranslational modification] 210007000748 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 210007000749 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 210007000750 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 210007000751 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 210007000752 TPP-binding site [chemical binding]; other site 210007000753 dimer interface [polypeptide binding]; other site 210007000754 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 210007000755 PYR/PP interface [polypeptide binding]; other site 210007000756 dimer interface [polypeptide binding]; other site 210007000757 TPP binding site [chemical binding]; other site 210007000758 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 210007000759 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 210007000760 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 210007000761 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 210007000762 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 210007000763 LytTr DNA-binding domain; Region: LytTR; pfam04397 210007000764 Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893 210007000765 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 210007000766 DNA polymerase I; Provisional; Region: PRK05755 210007000767 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 210007000768 active site 210007000769 metal binding site 1 [ion binding]; metal-binding site 210007000770 putative 5' ssDNA interaction site; other site 210007000771 metal binding site 3; metal-binding site 210007000772 metal binding site 2 [ion binding]; metal-binding site 210007000773 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 210007000774 putative DNA binding site [nucleotide binding]; other site 210007000775 putative metal binding site [ion binding]; other site 210007000776 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 210007000777 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 210007000778 active site 210007000779 DNA binding site [nucleotide binding] 210007000780 catalytic site [active] 210007000781 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 210007000782 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 210007000783 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 210007000784 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 210007000785 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 210007000786 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 210007000787 putative active site [active] 210007000788 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 210007000789 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 210007000790 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 210007000791 nucleoside/Zn binding site; other site 210007000792 dimer interface [polypeptide binding]; other site 210007000793 catalytic motif [active] 210007000794 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 210007000795 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 210007000796 active site 210007000797 dimer interface [polypeptide binding]; other site 210007000798 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 210007000799 dimer interface [polypeptide binding]; other site 210007000800 active site 210007000801 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 210007000802 classical (c) SDRs; Region: SDR_c; cd05233 210007000803 NAD(P) binding site [chemical binding]; other site 210007000804 active site 210007000805 putative frv operon regulatory protein; Provisional; Region: PRK09863 210007000806 HTH domain; Region: HTH_11; pfam08279 210007000807 PRD domain; Region: PRD; pfam00874 210007000808 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 210007000809 active site 210007000810 P-loop; other site 210007000811 phosphorylation site [posttranslational modification] 210007000812 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 210007000813 active site 210007000814 phosphorylation site [posttranslational modification] 210007000815 Glucitol operon activator protein (GutM); Region: GutM; pfam06923 210007000816 PTS system enzyme II sorbitol-specific factor; Region: EII-GUT; pfam03608 210007000817 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 210007000818 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 210007000819 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 210007000820 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; pfam03829 210007000821 Class I aldolases; Region: Aldolase_Class_I; cl17187 210007000822 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 210007000823 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 210007000824 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 210007000825 putative trimer interface [polypeptide binding]; other site 210007000826 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 210007000827 putative CoA binding site [chemical binding]; other site 210007000828 putative trimer interface [polypeptide binding]; other site 210007000829 putative CoA binding site [chemical binding]; other site 210007000830 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 210007000831 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 210007000832 metal binding site [ion binding]; metal-binding site 210007000833 putative dimer interface [polypeptide binding]; other site 210007000834 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 210007000835 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 210007000836 Rhomboid family; Region: Rhomboid; pfam01694 210007000837 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 210007000838 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 210007000839 active site 210007000840 tetramer interface; other site 210007000841 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 210007000842 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 210007000843 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 210007000844 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 210007000845 trimer interface [polypeptide binding]; other site 210007000846 active site 210007000847 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 210007000848 catalytic triad [active] 210007000849 conserved cis-peptide bond; other site 210007000850 DNA repair protein RadA; Provisional; Region: PRK11823 210007000851 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 210007000852 Walker A motif/ATP binding site; other site 210007000853 ATP binding site [chemical binding]; other site 210007000854 Walker B motif; other site 210007000855 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 210007000856 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 210007000857 active site clefts [active] 210007000858 zinc binding site [ion binding]; other site 210007000859 dimer interface [polypeptide binding]; other site 210007000860 Uncharacterized conserved protein [Function unknown]; Region: COG2013 210007000861 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 210007000862 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 210007000863 active site 210007000864 HIGH motif; other site 210007000865 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 210007000866 active site 210007000867 KMSKS motif; other site 210007000868 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 210007000869 HTH domain; Region: HTH_11; pfam08279 210007000870 3H domain; Region: 3H; pfam02829 210007000871 Predicted membrane protein (DUF2232); Region: DUF2232; cl01728 210007000872 argininosuccinate synthase; Provisional; Region: PRK13820 210007000873 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 210007000874 ANP binding site [chemical binding]; other site 210007000875 Substrate Binding Site II [chemical binding]; other site 210007000876 Substrate Binding Site I [chemical binding]; other site 210007000877 argininosuccinate lyase; Provisional; Region: PRK00855 210007000878 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 210007000879 active sites [active] 210007000880 tetramer interface [polypeptide binding]; other site 210007000881 ribonuclease P; Reviewed; Region: rnpA; PRK00499 210007000882 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 210007000883 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 210007000884 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 210007000885 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 210007000886 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 210007000887 G-X-X-G motif; other site 210007000888 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 210007000889 RxxxH motif; other site 210007000890 Protein of unknown function (DUF998); Region: DUF998; pfam06197 210007000891 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 210007000892 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 210007000893 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 210007000894 active site 210007000895 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 210007000896 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 210007000897 putative active site [active] 210007000898 putative metal binding site [ion binding]; other site 210007000899 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 210007000900 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 210007000901 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 210007000902 Predicted transcriptional regulators [Transcription]; Region: COG1733 210007000903 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 210007000904 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 210007000905 dimer interface [polypeptide binding]; other site 210007000906 FMN binding site [chemical binding]; other site 210007000907 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 210007000908 nucleotide binding site/active site [active] 210007000909 HIT family signature motif; other site 210007000910 catalytic residue [active] 210007000911 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 210007000912 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 210007000913 S-adenosylmethionine binding site [chemical binding]; other site 210007000914 GTPase RsgA; Reviewed; Region: PRK00098 210007000915 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 210007000916 RNA binding site [nucleotide binding]; other site 210007000917 homodimer interface [polypeptide binding]; other site 210007000918 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 210007000919 GTPase/Zn-binding domain interface [polypeptide binding]; other site 210007000920 GTP/Mg2+ binding site [chemical binding]; other site 210007000921 G4 box; other site 210007000922 G1 box; other site 210007000923 Switch I region; other site 210007000924 G2 box; other site 210007000925 G3 box; other site 210007000926 Switch II region; other site 210007000927 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 210007000928 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 210007000929 substrate binding site [chemical binding]; other site 210007000930 hexamer interface [polypeptide binding]; other site 210007000931 metal binding site [ion binding]; metal-binding site 210007000932 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 210007000933 Thiamine pyrophosphokinase; Region: TPK; cd07995 210007000934 active site 210007000935 dimerization interface [polypeptide binding]; other site 210007000936 thiamine binding site [chemical binding]; other site 210007000937 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 210007000938 RmuC family; Region: RmuC; pfam02646 210007000939 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 210007000940 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 210007000941 generic binding surface II; other site 210007000942 generic binding surface I; other site 210007000943 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 210007000944 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 210007000945 Zn2+ binding site [ion binding]; other site 210007000946 Mg2+ binding site [ion binding]; other site 210007000947 pur operon repressor; Provisional; Region: PRK09213 210007000948 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 210007000949 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 210007000950 active site 210007000951 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 210007000952 S17 interaction site [polypeptide binding]; other site 210007000953 S8 interaction site; other site 210007000954 16S rRNA interaction site [nucleotide binding]; other site 210007000955 streptomycin interaction site [chemical binding]; other site 210007000956 23S rRNA interaction site [nucleotide binding]; other site 210007000957 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 210007000958 30S ribosomal protein S7; Validated; Region: PRK05302 210007000959 elongation factor G; Reviewed; Region: PRK00007 210007000960 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 210007000961 G1 box; other site 210007000962 putative GEF interaction site [polypeptide binding]; other site 210007000963 GTP/Mg2+ binding site [chemical binding]; other site 210007000964 Switch I region; other site 210007000965 G2 box; other site 210007000966 G3 box; other site 210007000967 Switch II region; other site 210007000968 G4 box; other site 210007000969 G5 box; other site 210007000970 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 210007000971 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 210007000972 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 210007000973 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 210007000974 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 210007000975 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 210007000976 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 210007000977 Phosphoglycerate kinase; Region: PGK; pfam00162 210007000978 substrate binding site [chemical binding]; other site 210007000979 hinge regions; other site 210007000980 ADP binding site [chemical binding]; other site 210007000981 catalytic site [active] 210007000982 Predicted membrane protein [Function unknown]; Region: COG4129 210007000983 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 210007000984 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 210007000985 DNA binding residues [nucleotide binding] 210007000986 putative dimer interface [polypeptide binding]; other site 210007000987 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 210007000988 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 210007000989 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 210007000990 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 210007000991 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 210007000992 active site 210007000993 dimer interface [polypeptide binding]; other site 210007000994 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 210007000995 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 210007000996 active site 210007000997 FMN binding site [chemical binding]; other site 210007000998 substrate binding site [chemical binding]; other site 210007000999 3Fe-4S cluster binding site [ion binding]; other site 210007001000 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 210007001001 domain interface; other site 210007001002 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 210007001003 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 210007001004 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 210007001005 Surface antigen [General function prediction only]; Region: COG3942 210007001006 CHAP domain; Region: CHAP; pfam05257 210007001007 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 210007001008 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 210007001009 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 210007001010 hypothetical protein; Provisional; Region: PRK13667 210007001011 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 210007001012 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 210007001013 Walker A/P-loop; other site 210007001014 ATP binding site [chemical binding]; other site 210007001015 Q-loop/lid; other site 210007001016 ABC transporter signature motif; other site 210007001017 Walker B; other site 210007001018 D-loop; other site 210007001019 H-loop/switch region; other site 210007001020 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 210007001021 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 210007001022 classical (c) SDRs; Region: SDR_c; cd05233 210007001023 NAD(P) binding site [chemical binding]; other site 210007001024 active site 210007001025 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 210007001026 active site 210007001027 putative substrate binding region [chemical binding]; other site 210007001028 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 210007001029 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 210007001030 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 210007001031 catalytic residue [active] 210007001032 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 210007001033 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 210007001034 non-specific DNA binding site [nucleotide binding]; other site 210007001035 salt bridge; other site 210007001036 sequence-specific DNA binding site [nucleotide binding]; other site 210007001037 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 210007001038 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 210007001039 active site 210007001040 catalytic tetrad [active] 210007001041 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 210007001042 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 210007001043 putative NADP binding site [chemical binding]; other site 210007001044 putative substrate binding site [chemical binding]; other site 210007001045 active site 210007001046 Transcriptional regulators [Transcription]; Region: MarR; COG1846 210007001047 MarR family; Region: MarR_2; pfam12802 210007001048 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 210007001049 Glycoprotease family; Region: Peptidase_M22; pfam00814 210007001050 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 210007001051 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 210007001052 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 210007001053 Coenzyme A binding pocket [chemical binding]; other site 210007001054 UGMP family protein; Validated; Region: PRK09604 210007001055 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 210007001056 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 210007001057 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 210007001058 Predicted membrane protein [Function unknown]; Region: COG4392 210007001059 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 210007001060 HI0933-like protein; Region: HI0933_like; pfam03486 210007001061 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 210007001062 Protein of unknown function, DUF536; Region: DUF536; pfam04394 210007001063 hypothetical protein; Validated; Region: PRK00153 210007001064 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 210007001065 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; pfam09168 210007001066 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 210007001067 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 210007001068 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 210007001069 amphipathic channel; other site 210007001070 Asn-Pro-Ala signature motifs; other site 210007001071 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 210007001072 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 210007001073 Beta-lactamase; Region: Beta-lactamase; pfam00144 210007001074 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444 210007001075 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 210007001076 Coenzyme A binding pocket [chemical binding]; other site 210007001077 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 210007001078 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 210007001079 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 210007001080 active site 210007001081 DNA polymerase IV; Validated; Region: PRK02406 210007001082 DNA binding site [nucleotide binding] 210007001083 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 210007001084 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 210007001085 non-specific DNA binding site [nucleotide binding]; other site 210007001086 salt bridge; other site 210007001087 sequence-specific DNA binding site [nucleotide binding]; other site 210007001088 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 210007001089 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 210007001090 active site 210007001091 motif I; other site 210007001092 motif II; other site 210007001093 Protein of unknown function (DUF1361); Region: DUF1361; pfam07099 210007001094 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 210007001095 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 210007001096 Transcriptional regulator [Transcription]; Region: LytR; COG1316 210007001097 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 210007001098 HIT family signature motif; other site 210007001099 catalytic residue [active] 210007001100 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 210007001101 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 210007001102 Walker A/P-loop; other site 210007001103 ATP binding site [chemical binding]; other site 210007001104 Q-loop/lid; other site 210007001105 ABC transporter signature motif; other site 210007001106 Walker B; other site 210007001107 D-loop; other site 210007001108 H-loop/switch region; other site 210007001109 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 210007001110 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 210007001111 Thiamine kinase and related kinases [Coenzyme transport and metabolism]; Region: ycfN; COG0510 210007001112 Phosphotransferase enzyme family; Region: APH; pfam01636 210007001113 substrate binding site [chemical binding]; other site 210007001114 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 210007001115 S-adenosylmethionine binding site [chemical binding]; other site 210007001116 ribosome maturation protein RimP; Reviewed; Region: PRK00092 210007001117 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 210007001118 putative oligomer interface [polypeptide binding]; other site 210007001119 putative RNA binding site [nucleotide binding]; other site 210007001120 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 210007001121 NusA N-terminal domain; Region: NusA_N; pfam08529 210007001122 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 210007001123 RNA binding site [nucleotide binding]; other site 210007001124 homodimer interface [polypeptide binding]; other site 210007001125 NusA-like KH domain; Region: KH_5; pfam13184 210007001126 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 210007001127 G-X-X-G motif; other site 210007001128 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 210007001129 putative RNA binding cleft [nucleotide binding]; other site 210007001130 hypothetical protein; Provisional; Region: PRK07283 210007001131 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 210007001132 translation initiation factor IF-2; Region: IF-2; TIGR00487 210007001133 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 210007001134 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 210007001135 G1 box; other site 210007001136 putative GEF interaction site [polypeptide binding]; other site 210007001137 GTP/Mg2+ binding site [chemical binding]; other site 210007001138 Switch I region; other site 210007001139 G2 box; other site 210007001140 G3 box; other site 210007001141 Switch II region; other site 210007001142 G4 box; other site 210007001143 G5 box; other site 210007001144 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 210007001145 Translation-initiation factor 2; Region: IF-2; pfam11987 210007001146 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 210007001147 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 210007001148 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 210007001149 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 210007001150 Penicillinase repressor; Region: Pencillinase_R; pfam03965 210007001151 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 210007001152 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 210007001153 metal-binding site [ion binding] 210007001154 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 210007001155 Soluble P-type ATPase [General function prediction only]; Region: COG4087 210007001156 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207 210007001157 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 210007001158 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 210007001159 active site 210007001160 motif I; other site 210007001161 motif II; other site 210007001162 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 210007001163 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 210007001164 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 210007001165 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 210007001166 Walker A/P-loop; other site 210007001167 ATP binding site [chemical binding]; other site 210007001168 Q-loop/lid; other site 210007001169 ABC transporter signature motif; other site 210007001170 Walker B; other site 210007001171 D-loop; other site 210007001172 H-loop/switch region; other site 210007001173 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 210007001174 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 210007001175 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 210007001176 LytTr DNA-binding domain; Region: LytTR; pfam04397 210007001177 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 210007001178 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 210007001179 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 210007001180 active site 210007001181 dimer interface [polypeptide binding]; other site 210007001182 putative transposase OrfB; Reviewed; Region: PHA02517 210007001183 HTH-like domain; Region: HTH_21; pfam13276 210007001184 Integrase core domain; Region: rve; pfam00665 210007001185 Integrase core domain; Region: rve_2; pfam13333 210007001186 Best Blastp Hit: gb|AAF73805.1|AF154034_2 (AF154034) hypothetical protein [Streptococcus pneumoniae] 210007001187 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 210007001188 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 210007001189 BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271 210007001190 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3580 210007001191 2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050 210007001192 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581 210007001193 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 210007001194 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 210007001195 Ligand-binding SRPBCC domain of Streptococcus mutans Smu.440 and related proteins; Region: SRPBCC_Smu440-like; cd08862 210007001196 putative hydrophobic ligand binding site [chemical binding]; other site 210007001197 Transcriptional regulators [Transcription]; Region: MarR; COG1846 210007001198 MarR family; Region: MarR; pfam01047 210007001199 MarR family; Region: MarR_2; cl17246 210007001200 hypothetical protein; Provisional; Region: PRK02268 210007001201 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 210007001202 dimer interface [polypeptide binding]; other site 210007001203 motif 1; other site 210007001204 active site 210007001205 motif 2; other site 210007001206 motif 3; other site 210007001207 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 210007001208 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 210007001209 DALR anticodon binding domain; Region: DALR_1; pfam05746 210007001210 hypothetical protein; Provisional; Region: PRK02539 210007001211 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 210007001212 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 210007001213 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 210007001214 nucleotide binding site [chemical binding]; other site 210007001215 homotetrameric interface [polypeptide binding]; other site 210007001216 putative phosphate binding site [ion binding]; other site 210007001217 putative allosteric binding site; other site 210007001218 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 210007001219 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 210007001220 putative catalytic cysteine [active] 210007001221 MraW methylase family; Region: Methyltransf_5; pfam01795 210007001222 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 210007001223 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 210007001224 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 210007001225 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 210007001226 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 210007001227 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 210007001228 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 210007001229 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 210007001230 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 210007001231 Mg++ binding site [ion binding]; other site 210007001232 putative catalytic motif [active] 210007001233 putative substrate binding site [chemical binding]; other site 210007001234 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 210007001235 DEAD-like helicases superfamily; Region: DEXDc; smart00487 210007001236 ATP binding site [chemical binding]; other site 210007001237 Mg++ binding site [ion binding]; other site 210007001238 motif III; other site 210007001239 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 210007001240 nucleotide binding region [chemical binding]; other site 210007001241 ATP-binding site [chemical binding]; other site 210007001242 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 210007001243 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 210007001244 substrate binding pocket [chemical binding]; other site 210007001245 membrane-bound complex binding site; other site 210007001246 hinge residues; other site 210007001247 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 210007001248 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 210007001249 dimer interface [polypeptide binding]; other site 210007001250 conserved gate region; other site 210007001251 putative PBP binding loops; other site 210007001252 ABC-ATPase subunit interface; other site 210007001253 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 210007001254 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 210007001255 Walker A/P-loop; other site 210007001256 ATP binding site [chemical binding]; other site 210007001257 Q-loop/lid; other site 210007001258 ABC transporter signature motif; other site 210007001259 Walker B; other site 210007001260 D-loop; other site 210007001261 H-loop/switch region; other site 210007001262 Protein of unknown function (DUF4059); Region: DUF4059; pfam13268 210007001263 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 210007001264 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 210007001265 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 210007001266 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 210007001267 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 210007001268 active site 210007001269 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 210007001270 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 210007001271 homodimer interface [polypeptide binding]; other site 210007001272 NAD binding pocket [chemical binding]; other site 210007001273 ATP binding pocket [chemical binding]; other site 210007001274 Mg binding site [ion binding]; other site 210007001275 active-site loop [active] 210007001276 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 210007001277 trimer interface [polypeptide binding]; other site 210007001278 active site 210007001279 G bulge; other site 210007001280 Transglycosylase; Region: Transgly; pfam00912 210007001281 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 210007001282 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 210007001283 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 210007001284 hypothetical protein; Provisional; Region: PRK13660 210007001285 cell division protein GpsB; Provisional; Region: PRK14127 210007001286 DivIVA domain; Region: DivI1A_domain; TIGR03544 210007001287 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 210007001288 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 210007001289 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 210007001290 S-ribosylhomocysteinase; Provisional; Region: PRK02260 210007001291 hypothetical protein; Provisional; Region: PRK00106 210007001292 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 210007001293 Zn2+ binding site [ion binding]; other site 210007001294 Mg2+ binding site [ion binding]; other site 210007001295 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 210007001296 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 210007001297 catalytic site [active] 210007001298 G-X2-G-X-G-K; other site 210007001299 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 210007001300 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 210007001301 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 210007001302 ATP binding site [chemical binding]; other site 210007001303 putative Mg++ binding site [ion binding]; other site 210007001304 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 210007001305 nucleotide binding region [chemical binding]; other site 210007001306 ATP-binding site [chemical binding]; other site 210007001307 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 210007001308 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 210007001309 putative active site [active] 210007001310 substrate binding site [chemical binding]; other site 210007001311 putative cosubstrate binding site; other site 210007001312 catalytic site [active] 210007001313 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 210007001314 substrate binding site [chemical binding]; other site 210007001315 16S rRNA methyltransferase B; Provisional; Region: PRK14902 210007001316 NusB family; Region: NusB; pfam01029 210007001317 putative RNA binding site [nucleotide binding]; other site 210007001318 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 210007001319 S-adenosylmethionine binding site [chemical binding]; other site 210007001320 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 210007001321 active site 210007001322 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 210007001323 Catalytic domain of Protein Kinases; Region: PKc; cd00180 210007001324 active site 210007001325 ATP binding site [chemical binding]; other site 210007001326 substrate binding site [chemical binding]; other site 210007001327 activation loop (A-loop); other site 210007001328 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 210007001329 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 210007001330 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 210007001331 PASTA domain; Region: PASTA; pfam03793 210007001332 Predicted membrane protein [Function unknown]; Region: COG4758 210007001333 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 210007001334 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 210007001335 Histidine kinase; Region: HisKA_3; pfam07730 210007001336 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 210007001337 ATP binding site [chemical binding]; other site 210007001338 Mg2+ binding site [ion binding]; other site 210007001339 G-X-G motif; other site 210007001340 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 210007001341 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 210007001342 active site 210007001343 phosphorylation site [posttranslational modification] 210007001344 intermolecular recognition site; other site 210007001345 dimerization interface [polypeptide binding]; other site 210007001346 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 210007001347 DNA binding residues [nucleotide binding] 210007001348 dimerization interface [polypeptide binding]; other site 210007001349 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 210007001350 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 210007001351 active site 210007001352 motif I; other site 210007001353 motif II; other site 210007001354 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 210007001355 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 210007001356 active site 210007001357 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 210007001358 hypothetical protein; Provisional; Region: PRK07252 210007001359 RNA binding site [nucleotide binding]; other site 210007001360 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 210007001361 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 210007001362 FeS/SAM binding site; other site 210007001363 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 210007001364 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 210007001365 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 210007001366 Pyruvate-formate lyase [Energy production and conversion]; Region: PflD; COG1882 210007001367 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 210007001368 dimer interface [polypeptide binding]; other site 210007001369 active site 210007001370 glycine loop; other site 210007001371 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 210007001372 active site 210007001373 intersubunit interactions; other site 210007001374 catalytic residue [active] 210007001375 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 210007001376 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 210007001377 dimer interface [polypeptide binding]; other site 210007001378 active site 210007001379 metal binding site [ion binding]; metal-binding site 210007001380 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 210007001381 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 210007001382 dimer interface [polypeptide binding]; other site 210007001383 pyridoxal 5'-phosphate binding site [chemical binding]; other site 210007001384 catalytic residue [active] 210007001385 Uncharacterized conserved protein [Function unknown]; Region: COG1739 210007001386 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 210007001387 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 210007001388 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 210007001389 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 210007001390 ATP binding site [chemical binding]; other site 210007001391 putative Mg++ binding site [ion binding]; other site 210007001392 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 210007001393 nucleotide binding region [chemical binding]; other site 210007001394 ATP-binding site [chemical binding]; other site 210007001395 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 210007001396 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 210007001397 active site 210007001398 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 210007001399 30S subunit binding site; other site 210007001400 Predicted membrane protein [Function unknown]; Region: COG4640 210007001401 DNA adenine methylase (dam); Region: dam; TIGR00571 210007001402 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 210007001403 DNA methylase; Region: N6_N4_Mtase; pfam01555 210007001404 DpnII restriction endonuclease; Region: DpnII; pfam04556 210007001405 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 210007001406 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 210007001407 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 210007001408 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 210007001409 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 210007001410 active site 210007001411 motif I; other site 210007001412 motif II; other site 210007001413 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 210007001414 motif II; other site 210007001415 Protein of unknown function (DUF419); Region: DUF419; cl15265 210007001416 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 210007001417 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 210007001418 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 210007001419 myosin-cross-reactive antigen; Provisional; Region: PRK13977 210007001420 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 210007001421 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 210007001422 S-adenosylmethionine binding site [chemical binding]; other site 210007001423 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 210007001424 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 210007001425 active site 210007001426 (T/H)XGH motif; other site 210007001427 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 210007001428 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 210007001429 protein binding site [polypeptide binding]; other site 210007001430 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 210007001431 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 210007001432 active site 210007001433 metal binding site [ion binding]; metal-binding site 210007001434 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 210007001435 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 210007001436 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 210007001437 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 210007001438 FeS/SAM binding site; other site 210007001439 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 210007001440 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 210007001441 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 210007001442 Walker A/P-loop; other site 210007001443 ATP binding site [chemical binding]; other site 210007001444 Q-loop/lid; other site 210007001445 ABC transporter signature motif; other site 210007001446 Walker B; other site 210007001447 D-loop; other site 210007001448 H-loop/switch region; other site 210007001449 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 210007001450 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 210007001451 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 210007001452 Walker A/P-loop; other site 210007001453 ATP binding site [chemical binding]; other site 210007001454 Q-loop/lid; other site 210007001455 ABC transporter signature motif; other site 210007001456 Walker B; other site 210007001457 D-loop; other site 210007001458 H-loop/switch region; other site 210007001459 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 210007001460 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 210007001461 DNA binding residues [nucleotide binding] 210007001462 drug binding residues [chemical binding]; other site 210007001463 dimer interface [polypeptide binding]; other site 210007001464 Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804 210007001465 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 210007001466 Uncharacterized conserved protein [Function unknown]; Region: COG1359 210007001467 Protein of unknown function (DUF975); Region: DUF975; pfam06161 210007001468 Chorismate mutase type II; Region: CM_2; smart00830 210007001469 anthranilate synthase component I; Provisional; Region: PRK13570 210007001470 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 210007001471 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 210007001472 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 210007001473 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 210007001474 glutamine binding [chemical binding]; other site 210007001475 catalytic triad [active] 210007001476 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 210007001477 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 210007001478 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 210007001479 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 210007001480 active site 210007001481 ribulose/triose binding site [chemical binding]; other site 210007001482 phosphate binding site [ion binding]; other site 210007001483 substrate (anthranilate) binding pocket [chemical binding]; other site 210007001484 product (indole) binding pocket [chemical binding]; other site 210007001485 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 210007001486 active site 210007001487 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 210007001488 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 210007001489 pyridoxal 5'-phosphate binding site [chemical binding]; other site 210007001490 catalytic residue [active] 210007001491 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 210007001492 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 210007001493 substrate binding site [chemical binding]; other site 210007001494 active site 210007001495 catalytic residues [active] 210007001496 heterodimer interface [polypeptide binding]; other site 210007001497 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 210007001498 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 210007001499 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 210007001500 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 210007001501 dimerization interface [polypeptide binding]; other site 210007001502 DPS ferroxidase diiron center [ion binding]; other site 210007001503 ion pore; other site 210007001504 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 210007001505 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 210007001506 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 210007001507 nucleotide binding site [chemical binding]; other site 210007001508 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 210007001509 active site residue [active] 210007001510 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 210007001511 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 210007001512 G1 box; other site 210007001513 putative GEF interaction site [polypeptide binding]; other site 210007001514 GTP/Mg2+ binding site [chemical binding]; other site 210007001515 Switch I region; other site 210007001516 G2 box; other site 210007001517 G3 box; other site 210007001518 Switch II region; other site 210007001519 G4 box; other site 210007001520 G5 box; other site 210007001521 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 210007001522 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 210007001523 Protein of unknown function (DUF3165); Region: DUF3165; pfam11364 210007001524 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 210007001525 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 210007001526 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 210007001527 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 210007001528 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 210007001529 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 210007001530 active site 210007001531 homodimer interface [polypeptide binding]; other site 210007001532 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 210007001533 Cell division protein FtsQ; Region: FtsQ; pfam03799 210007001534 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 210007001535 Cell division protein FtsA; Region: FtsA; smart00842 210007001536 Cell division protein FtsA; Region: FtsA; pfam14450 210007001537 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 210007001538 cell division protein FtsZ; Validated; Region: PRK09330 210007001539 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 210007001540 nucleotide binding site [chemical binding]; other site 210007001541 SulA interaction site; other site 210007001542 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 210007001543 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 210007001544 catalytic residue [active] 210007001545 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 210007001546 YGGT family; Region: YGGT; pfam02325 210007001547 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 210007001548 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 210007001549 RNA binding surface [nucleotide binding]; other site 210007001550 DivIVA protein; Region: DivIVA; pfam05103 210007001551 DivIVA domain; Region: DivI1A_domain; TIGR03544 210007001552 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 210007001553 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 210007001554 active site 210007001555 HIGH motif; other site 210007001556 nucleotide binding site [chemical binding]; other site 210007001557 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 210007001558 active site 210007001559 KMSKS motif; other site 210007001560 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 210007001561 tRNA binding surface [nucleotide binding]; other site 210007001562 anticodon binding site; other site 210007001563 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 210007001564 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 210007001565 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 210007001566 nudix motif; other site 210007001567 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 210007001568 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 210007001569 Walker A motif; other site 210007001570 ATP binding site [chemical binding]; other site 210007001571 Walker B motif; other site 210007001572 arginine finger; other site 210007001573 UvrB/uvrC motif; Region: UVR; pfam02151 210007001574 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 210007001575 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 210007001576 Walker A motif; other site 210007001577 ATP binding site [chemical binding]; other site 210007001578 Walker B motif; other site 210007001579 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 210007001580 ornithine carbamoyltransferase; Validated; Region: PRK02102 210007001581 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 210007001582 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 210007001583 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 210007001584 putative transposase OrfB; Reviewed; Region: PHA02517 210007001585 HTH-like domain; Region: HTH_21; pfam13276 210007001586 Integrase core domain; Region: rve; pfam00665 210007001587 Integrase core domain; Region: rve_2; pfam13333 210007001588 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 210007001589 Homeodomain-like domain; Region: HTH_23; cl17451 210007001590 Transposase; Region: HTH_Tnp_1; cl17663 210007001591 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 210007001592 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 210007001593 dimer interface [polypeptide binding]; other site 210007001594 conserved gate region; other site 210007001595 putative PBP binding loops; other site 210007001596 ABC-ATPase subunit interface; other site 210007001597 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 210007001598 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 210007001599 Walker A/P-loop; other site 210007001600 ATP binding site [chemical binding]; other site 210007001601 Q-loop/lid; other site 210007001602 ABC transporter signature motif; other site 210007001603 Walker B; other site 210007001604 D-loop; other site 210007001605 H-loop/switch region; other site 210007001606 FeoA domain; Region: FeoA; pfam04023 210007001607 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 210007001608 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 210007001609 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 210007001610 G1 box; other site 210007001611 GTP/Mg2+ binding site [chemical binding]; other site 210007001612 Switch I region; other site 210007001613 G2 box; other site 210007001614 G3 box; other site 210007001615 Switch II region; other site 210007001616 G4 box; other site 210007001617 G5 box; other site 210007001618 Nucleoside recognition; Region: Gate; pfam07670 210007001619 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 210007001620 Nucleoside recognition; Region: Gate; pfam07670 210007001621 TraL protein; Region: TraL; cl06278 210007001622 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179 210007001623 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 210007001624 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 210007001625 homodimer interface [polypeptide binding]; other site 210007001626 NADP binding site [chemical binding]; other site 210007001627 substrate binding site [chemical binding]; other site 210007001628 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 210007001629 putative substrate binding site [chemical binding]; other site 210007001630 putative ATP binding site [chemical binding]; other site 210007001631 LrgB-like family; Region: LrgB; cl00596 210007001632 LrgA family; Region: LrgA; cl00608 210007001633 two-component response regulator; Provisional; Region: PRK14084 210007001634 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 210007001635 active site 210007001636 phosphorylation site [posttranslational modification] 210007001637 intermolecular recognition site; other site 210007001638 dimerization interface [polypeptide binding]; other site 210007001639 LytTr DNA-binding domain; Region: LytTR; pfam04397 210007001640 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 210007001641 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 210007001642 GAF domain; Region: GAF_3; pfam13492 210007001643 Histidine kinase; Region: His_kinase; pfam06580 210007001644 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 210007001645 ATP binding site [chemical binding]; other site 210007001646 Mg2+ binding site [ion binding]; other site 210007001647 G-X-G motif; other site 210007001648 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 210007001649 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 210007001650 generic binding surface II; other site 210007001651 generic binding surface I; other site 210007001652 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 210007001653 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 210007001654 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 210007001655 substrate binding pocket [chemical binding]; other site 210007001656 chain length determination region; other site 210007001657 substrate-Mg2+ binding site; other site 210007001658 catalytic residues [active] 210007001659 aspartate-rich region 1; other site 210007001660 active site lid residues [active] 210007001661 aspartate-rich region 2; other site 210007001662 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 210007001663 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 210007001664 RNA binding surface [nucleotide binding]; other site 210007001665 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 210007001666 Arginine repressor [Transcription]; Region: ArgR; COG1438 210007001667 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 210007001668 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 210007001669 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 210007001670 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 210007001671 Walker A/P-loop; other site 210007001672 ATP binding site [chemical binding]; other site 210007001673 Q-loop/lid; other site 210007001674 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 210007001675 ABC transporter signature motif; other site 210007001676 Walker B; other site 210007001677 D-loop; other site 210007001678 H-loop/switch region; other site 210007001679 EDD domain protein, DegV family; Region: DegV; TIGR00762 210007001680 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 210007001681 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 210007001682 active site 210007001683 catalytic triad [active] 210007001684 oxyanion hole [active] 210007001685 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 210007001686 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 210007001687 IHF dimer interface [polypeptide binding]; other site 210007001688 IHF - DNA interface [nucleotide binding]; other site 210007001689 Integrase core domain; Region: rve_2; pfam13333 210007001690 hypothetical protein; Provisional; Region: PRK14851 210007001691 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 210007001692 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 210007001693 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 210007001694 metal binding site 2 [ion binding]; metal-binding site 210007001695 putative DNA binding helix; other site 210007001696 metal binding site 1 [ion binding]; metal-binding site 210007001697 dimer interface [polypeptide binding]; other site 210007001698 structural Zn2+ binding site [ion binding]; other site 210007001699 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 210007001700 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 210007001701 active site 210007001702 FMN binding site [chemical binding]; other site 210007001703 substrate binding site [chemical binding]; other site 210007001704 catalytic residues [active] 210007001705 homodimer interface [polypeptide binding]; other site 210007001706 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 210007001707 catalytic core [active] 210007001708 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 210007001709 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 210007001710 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 210007001711 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 210007001712 recombination protein RecR; Reviewed; Region: recR; PRK00076 210007001713 RecR protein; Region: RecR; pfam02132 210007001714 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 210007001715 putative active site [active] 210007001716 putative metal-binding site [ion binding]; other site 210007001717 tetramer interface [polypeptide binding]; other site 210007001718 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 210007001719 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 210007001720 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 210007001721 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 210007001722 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 210007001723 Sodium Bile acid symporter family; Region: SBF; cl17470 210007001724 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 210007001725 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 210007001726 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 210007001727 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 210007001728 TIR domain; Region: TIR_2; pfam13676 210007001729 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 210007001730 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 210007001731 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 210007001732 G1 box; other site 210007001733 putative GEF interaction site [polypeptide binding]; other site 210007001734 GTP/Mg2+ binding site [chemical binding]; other site 210007001735 Switch I region; other site 210007001736 G2 box; other site 210007001737 G3 box; other site 210007001738 Switch II region; other site 210007001739 G4 box; other site 210007001740 G5 box; other site 210007001741 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 210007001742 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 210007001743 Bacterial SH3 domain; Region: SH3_5; pfam08460 210007001744 Bacterial SH3 domain; Region: SH3_5; pfam08460 210007001745 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 210007001746 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 210007001747 Bacterial SH3 domain; Region: SH3_5; pfam08460 210007001748 putative cross-wall-targeting lipoprotein signal; Region: strep_RK_lipo; TIGR03726 210007001749 Streptococcal surface antigen repeat; Region: Strep_SA_rep; pfam06696 210007001750 Streptococcal surface antigen repeat; Region: Strep_SA_rep; pfam06696 210007001751 Glucan-binding protein C; Region: GbpC; pfam08363 210007001752 adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228 210007001753 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 210007001754 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 210007001755 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 210007001756 ATP binding site [chemical binding]; other site 210007001757 Mg++ binding site [ion binding]; other site 210007001758 motif III; other site 210007001759 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 210007001760 nucleotide binding region [chemical binding]; other site 210007001761 ATP-binding site [chemical binding]; other site 210007001762 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 210007001763 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 210007001764 S-adenosylmethionine binding site [chemical binding]; other site 210007001765 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 210007001766 GIY-YIG motif/motif A; other site 210007001767 putative active site [active] 210007001768 putative metal binding site [ion binding]; other site 210007001769 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 210007001770 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 210007001771 Catalytic NodB homology domain of Streptococcus mutans polysaccharide deacetylase PgdA, Bacillus subtilis YheN, and similar proteins; Region: CE4_SmPgdA_like; cd10944 210007001772 NodB motif; other site 210007001773 active site 210007001774 catalytic site [active] 210007001775 Zn binding site [ion binding]; other site 210007001776 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 210007001777 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 210007001778 putative acyl-acceptor binding pocket; other site 210007001779 SLBB domain; Region: SLBB; pfam10531 210007001780 comEA protein; Region: comE; TIGR01259 210007001781 Helix-hairpin-helix motif; Region: HHH; pfam00633 210007001782 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 210007001783 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 210007001784 Telomere length regulation protein; Region: Telomere_reg-2; pfam10193 210007001785 Competence protein; Region: Competence; pfam03772 210007001786 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 210007001787 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 210007001788 Protein of unknown function (DUF805); Region: DUF805; cl01224 210007001789 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 210007001790 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 210007001791 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 210007001792 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 210007001793 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 210007001794 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 210007001795 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 210007001796 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 210007001797 MarR family; Region: MarR_2; pfam12802 210007001798 Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775 210007001799 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 210007001800 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 210007001801 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 210007001802 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 210007001803 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 210007001804 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 210007001805 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 210007001806 active site 210007001807 trimer interface [polypeptide binding]; other site 210007001808 allosteric site; other site 210007001809 active site lid [active] 210007001810 hexamer (dimer of trimers) interface [polypeptide binding]; other site 210007001811 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 210007001812 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 210007001813 RNA binding surface [nucleotide binding]; other site 210007001814 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 210007001815 active site 210007001816 uracil binding [chemical binding]; other site 210007001817 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 210007001818 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 210007001819 Coenzyme A binding pocket [chemical binding]; other site 210007001820 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 210007001821 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 210007001822 DNA-binding site [nucleotide binding]; DNA binding site 210007001823 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 210007001824 pyridoxal 5'-phosphate binding site [chemical binding]; other site 210007001825 homodimer interface [polypeptide binding]; other site 210007001826 catalytic residue [active] 210007001827 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 210007001828 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 210007001829 NAD(P) binding site [chemical binding]; other site 210007001830 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 210007001831 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 210007001832 Competence protein CoiA-like family; Region: CoiA; pfam06054 210007001833 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 210007001834 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 210007001835 active site 210007001836 Zn binding site [ion binding]; other site 210007001837 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 210007001838 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 210007001839 motif II; other site 210007001840 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 210007001841 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 210007001842 S-adenosylmethionine binding site [chemical binding]; other site 210007001843 foldase protein PrsA; Reviewed; Region: prsA; PRK01326 210007001844 SurA N-terminal domain; Region: SurA_N; pfam09312 210007001845 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 210007001846 Tubby C 2; Region: Tub_2; cl02043 210007001847 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 210007001848 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 210007001849 motif 1; other site 210007001850 active site 210007001851 motif 2; other site 210007001852 motif 3; other site 210007001853 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 210007001854 DHHA1 domain; Region: DHHA1; pfam02272 210007001855 NMT1-like family; Region: NMT1_2; pfam13379 210007001856 NMT1/THI5 like; Region: NMT1; pfam09084 210007001857 substrate binding pocket [chemical binding]; other site 210007001858 membrane-bound complex binding site; other site 210007001859 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 210007001860 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 210007001861 Walker A/P-loop; other site 210007001862 ATP binding site [chemical binding]; other site 210007001863 Q-loop/lid; other site 210007001864 ABC transporter signature motif; other site 210007001865 Walker B; other site 210007001866 D-loop; other site 210007001867 H-loop/switch region; other site 210007001868 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 210007001869 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 210007001870 dimer interface [polypeptide binding]; other site 210007001871 conserved gate region; other site 210007001872 putative PBP binding loops; other site 210007001873 ABC-ATPase subunit interface; other site 210007001874 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 210007001875 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 210007001876 Walker A/P-loop; other site 210007001877 ATP binding site [chemical binding]; other site 210007001878 Q-loop/lid; other site 210007001879 ABC transporter signature motif; other site 210007001880 Walker B; other site 210007001881 D-loop; other site 210007001882 H-loop/switch region; other site 210007001883 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 210007001884 lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732 210007001885 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 210007001886 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 210007001887 TraX protein; Region: TraX; cl05434 210007001888 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 210007001889 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 210007001890 active site 210007001891 phosphorylation site [posttranslational modification] 210007001892 intermolecular recognition site; other site 210007001893 dimerization interface [polypeptide binding]; other site 210007001894 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 210007001895 DNA binding site [nucleotide binding] 210007001896 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 210007001897 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 210007001898 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 210007001899 dimer interface [polypeptide binding]; other site 210007001900 phosphorylation site [posttranslational modification] 210007001901 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 210007001902 ATP binding site [chemical binding]; other site 210007001903 Mg2+ binding site [ion binding]; other site 210007001904 G-X-G motif; other site 210007001905 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 210007001906 non-specific DNA binding site [nucleotide binding]; other site 210007001907 salt bridge; other site 210007001908 sequence-specific DNA binding site [nucleotide binding]; other site 210007001909 CAAX protease self-immunity; Region: Abi; pfam02517 210007001910 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 210007001911 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 210007001912 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 210007001913 heterotetramer interface [polypeptide binding]; other site 210007001914 active site pocket [active] 210007001915 cleavage site 210007001916 AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238 210007001917 nucleotide binding site [chemical binding]; other site 210007001918 N-acetyl-L-glutamate binding site [chemical binding]; other site 210007001919 acetylornithine aminotransferase; Provisional; Region: PRK04260 210007001920 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 210007001921 inhibitor-cofactor binding pocket; inhibition site 210007001922 pyridoxal 5'-phosphate binding site [chemical binding]; other site 210007001923 catalytic residue [active] 210007001924 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 210007001925 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 210007001926 dimer interface [polypeptide binding]; other site 210007001927 putative radical transfer pathway; other site 210007001928 diiron center [ion binding]; other site 210007001929 tyrosyl radical; other site 210007001930 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 210007001931 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 210007001932 Class I ribonucleotide reductase; Region: RNR_I; cd01679 210007001933 active site 210007001934 dimer interface [polypeptide binding]; other site 210007001935 catalytic residues [active] 210007001936 effector binding site; other site 210007001937 R2 peptide binding site; other site 210007001938 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 210007001939 catalytic residues [active] 210007001940 aconitate hydratase; Validated; Region: PRK09277 210007001941 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 210007001942 substrate binding site [chemical binding]; other site 210007001943 ligand binding site [chemical binding]; other site 210007001944 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 210007001945 substrate binding site [chemical binding]; other site 210007001946 Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110 210007001947 dimer interface [polypeptide binding]; other site 210007001948 Citrate synthase; Region: Citrate_synt; pfam00285 210007001949 active site 210007001950 citrylCoA binding site [chemical binding]; other site 210007001951 oxalacetate/citrate binding site [chemical binding]; other site 210007001952 coenzyme A binding site [chemical binding]; other site 210007001953 catalytic triad [active] 210007001954 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 210007001955 isocitrate dehydrogenase; Validated; Region: PRK06451 210007001956 Predicted membrane protein [Function unknown]; Region: COG4905 210007001957 Protein of unknown function (DUF1113); Region: DUF1113; pfam06541 210007001958 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 210007001959 dimerization domain swap beta strand [polypeptide binding]; other site 210007001960 regulatory protein interface [polypeptide binding]; other site 210007001961 active site 210007001962 regulatory phosphorylation site [posttranslational modification]; other site 210007001963 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 210007001964 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 210007001965 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 210007001966 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 210007001967 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 210007001968 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 210007001969 tetrameric interface [polypeptide binding]; other site 210007001970 activator binding site; other site 210007001971 NADP binding site [chemical binding]; other site 210007001972 substrate binding site [chemical binding]; other site 210007001973 catalytic residues [active] 210007001974 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 210007001975 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 210007001976 DNA binding residues [nucleotide binding] 210007001977 putative dimer interface [polypeptide binding]; other site 210007001978 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 210007001979 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 210007001980 active site 210007001981 catalytic tetrad [active] 210007001982 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 210007001983 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 210007001984 active site 210007001985 catalytic tetrad [active] 210007001986 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 210007001987 Macro domain, a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases). Some macro domains recognize poly...; Region: Macro; cl00019 210007001988 Dynamin family; Region: Dynamin_N; pfam00350 210007001989 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 210007001990 G1 box; other site 210007001991 GTP/Mg2+ binding site [chemical binding]; other site 210007001992 G2 box; other site 210007001993 Switch I region; other site 210007001994 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 210007001995 G2 box; other site 210007001996 Switch I region; other site 210007001997 G3 box; other site 210007001998 Switch II region; other site 210007001999 GTP/Mg2+ binding site [chemical binding]; other site 210007002000 G4 box; other site 210007002001 G5 box; other site 210007002002 Domain of unknown function DUF87; Region: DUF87; pfam01935 210007002003 AAA-like domain; Region: AAA_10; pfam12846 210007002004 A nuclease of the HNH/ENDO VII superfamily with conserved LHH; Region: LHH; pfam14411 210007002005 Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153 210007002006 Flagellin N-methylase; Region: FliB; pfam03692 210007002007 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 210007002008 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 210007002009 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 210007002010 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 210007002011 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 210007002012 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 210007002013 AtlA is an autolysin found in Gram-positive lactic acid bacteria that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. This family includes the AtlA and Aml...; Region: GH25_AtlA-like; cd06522 210007002014 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 210007002015 active site 210007002016 peptidase T; Region: peptidase-T; TIGR01882 210007002017 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 210007002018 metal binding site [ion binding]; metal-binding site 210007002019 dimer interface [polypeptide binding]; other site 210007002020 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 210007002021 cytidylate kinase; Provisional; Region: cmk; PRK00023 210007002022 AAA domain; Region: AAA_17; pfam13207 210007002023 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 210007002024 CMP-binding site; other site 210007002025 The sites determining sugar specificity; other site 210007002026 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 210007002027 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 210007002028 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 210007002029 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 210007002030 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 210007002031 23S rRNA binding site [nucleotide binding]; other site 210007002032 L21 binding site [polypeptide binding]; other site 210007002033 L13 binding site [polypeptide binding]; other site 210007002034 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 210007002035 catalytic core [active] 210007002036 hypothetical protein; Provisional; Region: PRK11770 210007002037 Domain of unknown function (DUF307); Region: DUF307; pfam03733 210007002038 Domain of unknown function (DUF307); Region: DUF307; pfam03733 210007002039 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 210007002040 putative deacylase active site [active] 210007002041 Predicted membrane protein [Function unknown]; Region: COG2035 210007002042 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 210007002043 amidase catalytic site [active] 210007002044 Zn binding residues [ion binding]; other site 210007002045 substrate binding site [chemical binding]; other site 210007002046 Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515 210007002047 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 210007002048 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 210007002049 active site 210007002050 Inner membrane protein CreD; Region: CreD; cl01844 210007002051 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 210007002052 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 210007002053 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 210007002054 elongation factor Tu; Reviewed; Region: PRK00049 210007002055 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 210007002056 G1 box; other site 210007002057 GEF interaction site [polypeptide binding]; other site 210007002058 GTP/Mg2+ binding site [chemical binding]; other site 210007002059 Switch I region; other site 210007002060 G2 box; other site 210007002061 G3 box; other site 210007002062 Switch II region; other site 210007002063 G4 box; other site 210007002064 G5 box; other site 210007002065 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 210007002066 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 210007002067 Antibiotic Binding Site [chemical binding]; other site 210007002068 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 210007002069 triosephosphate isomerase; Provisional; Region: PRK14565 210007002070 substrate binding site [chemical binding]; other site 210007002071 dimer interface [polypeptide binding]; other site 210007002072 catalytic triad [active] 210007002073 FemAB family; Region: FemAB; pfam02388 210007002074 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 210007002075 FemAB family; Region: FemAB; pfam02388 210007002076 sugar phosphate phosphatase; Provisional; Region: PRK10513 210007002077 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 210007002078 active site 210007002079 motif I; other site 210007002080 motif II; other site 210007002081 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 210007002082 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 210007002083 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 210007002084 Zn2+ binding site [ion binding]; other site 210007002085 Mg2+ binding site [ion binding]; other site 210007002086 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 210007002087 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 210007002088 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 210007002089 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 210007002090 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 210007002091 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 210007002092 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 210007002093 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 210007002094 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 210007002095 active site 210007002096 catalytic site [active] 210007002097 metal binding site [ion binding]; metal-binding site 210007002098 dimer interface [polypeptide binding]; other site 210007002099 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 210007002100 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 210007002101 active site 210007002102 metal binding site [ion binding]; metal-binding site 210007002103 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg3; cd01282 210007002104 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 210007002105 DNA binding residues [nucleotide binding] 210007002106 putative dimer interface [polypeptide binding]; other site 210007002107 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 210007002108 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 210007002109 putative NAD(P) binding site [chemical binding]; other site 210007002110 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 210007002111 looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439 210007002112 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 210007002113 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 210007002114 Walker A/P-loop; other site 210007002115 ATP binding site [chemical binding]; other site 210007002116 Q-loop/lid; other site 210007002117 ABC transporter signature motif; other site 210007002118 Walker B; other site 210007002119 D-loop; other site 210007002120 H-loop/switch region; other site 210007002121 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 210007002122 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 210007002123 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 210007002124 Protein of unknown function (DUF3114); Region: DUF3114; pfam11311 210007002125 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 210007002126 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 210007002127 active site 210007002128 motif I; other site 210007002129 motif II; other site 210007002130 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 210007002131 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 210007002132 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 210007002133 active site 210007002134 motif I; other site 210007002135 motif II; other site 210007002136 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 210007002137 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 210007002138 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 210007002139 P loop; other site 210007002140 GTP binding site [chemical binding]; other site 210007002141 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 210007002142 putative substrate translocation pore; other site 210007002143 Major Facilitator Superfamily; Region: MFS_1; pfam07690 210007002144 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 210007002145 Predicted membrane protein [Function unknown]; Region: COG3689 210007002146 Predicted permeases [General function prediction only]; Region: COG0701 210007002147 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 210007002148 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 210007002149 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 210007002150 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 210007002151 RNA binding site [nucleotide binding]; other site 210007002152 hypothetical protein; Provisional; Region: PRK04351 210007002153 SprT homologues; Region: SprT; cl01182 210007002154 PspC domain; Region: PspC; pfam04024 210007002155 HPr kinase/phosphorylase; Provisional; Region: PRK05428 210007002156 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 210007002157 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 210007002158 Hpr binding site; other site 210007002159 active site 210007002160 homohexamer subunit interaction site [polypeptide binding]; other site 210007002161 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 210007002162 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 210007002163 YtxH-like protein; Region: YtxH; pfam12732 210007002164 Protein of unknown function (DUF3270); Region: DUF3270; pfam11674 210007002165 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 210007002166 Peptidase family U32; Region: Peptidase_U32; pfam01136 210007002167 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 210007002168 Peptidase family U32; Region: Peptidase_U32; pfam01136 210007002169 peroxiredoxin; Region: AhpC; TIGR03137 210007002170 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 210007002171 dimer interface [polypeptide binding]; other site 210007002172 decamer (pentamer of dimers) interface [polypeptide binding]; other site 210007002173 catalytic triad [active] 210007002174 peroxidatic and resolving cysteines [active] 210007002175 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 210007002176 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 210007002177 catalytic residue [active] 210007002178 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 210007002179 catalytic residues [active] 210007002180 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 210007002181 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 210007002182 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 210007002183 Homeodomain-like domain; Region: HTH_23; cl17451 210007002184 Transposase; Region: HTH_Tnp_1; cl17663 210007002185 putative transposase OrfB; Reviewed; Region: PHA02517 210007002186 HTH-like domain; Region: HTH_21; pfam13276 210007002187 Integrase core domain; Region: rve; pfam00665 210007002188 Integrase core domain; Region: rve_2; pfam13333 210007002189 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 210007002190 manganese transport protein MntH; Reviewed; Region: PRK00701 210007002191 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 210007002192 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 210007002193 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 210007002194 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 210007002195 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 210007002196 Predicted peptidase [General function prediction only]; Region: COG4099 210007002197 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 210007002198 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 210007002199 dimer interface [polypeptide binding]; other site 210007002200 putative anticodon binding site; other site 210007002201 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 210007002202 motif 1; other site 210007002203 active site 210007002204 motif 2; other site 210007002205 motif 3; other site 210007002206 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 210007002207 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 210007002208 motif II; other site 210007002209 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 210007002210 Sulfatase; Region: Sulfatase; pfam00884 210007002211 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 210007002212 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 210007002213 putative RNA binding site [nucleotide binding]; other site 210007002214 Methyltransferase domain; Region: Methyltransf_26; pfam13659 210007002215 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 210007002216 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 210007002217 active site 210007002218 catalytic residue [active] 210007002219 dimer interface [polypeptide binding]; other site 210007002220 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 210007002221 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 210007002222 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 210007002223 NAD(P) binding site [chemical binding]; other site 210007002224 shikimate binding site; other site 210007002225 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 210007002226 active site 210007002227 dimer interface [polypeptide binding]; other site 210007002228 metal binding site [ion binding]; metal-binding site 210007002229 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 210007002230 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 210007002231 Tetramer interface [polypeptide binding]; other site 210007002232 active site 210007002233 FMN-binding site [chemical binding]; other site 210007002234 prephenate dehydrogenase; Validated; Region: PRK06545 210007002235 prephenate dehydrogenase; Validated; Region: PRK08507 210007002236 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 210007002237 hypothetical protein; Provisional; Region: PRK13676 210007002238 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 210007002239 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 210007002240 hinge; other site 210007002241 active site 210007002242 shikimate kinase; Reviewed; Region: aroK; PRK00131 210007002243 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 210007002244 ADP binding site [chemical binding]; other site 210007002245 magnesium binding site [ion binding]; other site 210007002246 putative shikimate binding site; other site 210007002247 prephenate dehydratase; Provisional; Region: PRK11898 210007002248 Prephenate dehydratase; Region: PDT; pfam00800 210007002249 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 210007002250 putative L-Phe binding site [chemical binding]; other site 210007002251 Transcriptional regulator [Transcription]; Region: LytR; COG1316 210007002252 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 210007002253 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 210007002254 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 210007002255 S-adenosylmethionine binding site [chemical binding]; other site 210007002256 CAAX protease self-immunity; Region: Abi; pfam02517 210007002257 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 210007002258 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 210007002259 non-specific DNA binding site [nucleotide binding]; other site 210007002260 salt bridge; other site 210007002261 sequence-specific DNA binding site [nucleotide binding]; other site 210007002262 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 210007002263 CoenzymeA binding site [chemical binding]; other site 210007002264 subunit interaction site [polypeptide binding]; other site 210007002265 PHB binding site; other site 210007002266 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 210007002267 active site 210007002268 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 210007002269 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 210007002270 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 210007002271 NADP binding site [chemical binding]; other site 210007002272 Predicted thioesterase [General function prediction only]; Region: COG5496 210007002273 GTPase CgtA; Reviewed; Region: obgE; PRK12297 210007002274 GTP1/OBG; Region: GTP1_OBG; pfam01018 210007002275 Obg GTPase; Region: Obg; cd01898 210007002276 G1 box; other site 210007002277 GTP/Mg2+ binding site [chemical binding]; other site 210007002278 Switch I region; other site 210007002279 G2 box; other site 210007002280 G3 box; other site 210007002281 Switch II region; other site 210007002282 G4 box; other site 210007002283 G5 box; other site 210007002284 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 210007002285 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 210007002286 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 210007002287 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 210007002288 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 210007002289 This domain contains a conserved N-terminal (F/Y)RG motif. It is functionally uncharacterised; Region: FRG; smart00901 210007002290 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 210007002291 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 210007002292 Walker A/P-loop; other site 210007002293 ATP binding site [chemical binding]; other site 210007002294 Q-loop/lid; other site 210007002295 ABC transporter signature motif; other site 210007002296 Walker B; other site 210007002297 D-loop; other site 210007002298 H-loop/switch region; other site 210007002299 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 210007002300 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 210007002301 substrate binding pocket [chemical binding]; other site 210007002302 membrane-bound complex binding site; other site 210007002303 hinge residues; other site 210007002304 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 210007002305 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 210007002306 substrate binding pocket [chemical binding]; other site 210007002307 membrane-bound complex binding site; other site 210007002308 hinge residues; other site 210007002309 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 210007002310 dimer interface [polypeptide binding]; other site 210007002311 conserved gate region; other site 210007002312 putative PBP binding loops; other site 210007002313 ABC-ATPase subunit interface; other site 210007002314 CAAX protease self-immunity; Region: Abi; pfam02517 210007002315 excinuclease ABC subunit B; Provisional; Region: PRK05298 210007002316 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 210007002317 ATP binding site [chemical binding]; other site 210007002318 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 210007002319 nucleotide binding region [chemical binding]; other site 210007002320 ATP-binding site [chemical binding]; other site 210007002321 Ultra-violet resistance protein B; Region: UvrB; pfam12344 210007002322 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 210007002323 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 210007002324 non-specific DNA binding site [nucleotide binding]; other site 210007002325 salt bridge; other site 210007002326 sequence-specific DNA binding site [nucleotide binding]; other site 210007002327 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 210007002328 putative active site [active] 210007002329 nucleotide binding site [chemical binding]; other site 210007002330 nudix motif; other site 210007002331 putative metal binding site [ion binding]; other site 210007002332 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 210007002333 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 210007002334 substrate binding pocket [chemical binding]; other site 210007002335 membrane-bound complex binding site; other site 210007002336 hinge residues; other site 210007002337 transaminase; Validated; Region: PRK07324 210007002338 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 210007002339 pyridoxal 5'-phosphate binding site [chemical binding]; other site 210007002340 homodimer interface [polypeptide binding]; other site 210007002341 catalytic residue [active] 210007002342 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 210007002343 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 210007002344 substrate binding pocket [chemical binding]; other site 210007002345 membrane-bound complex binding site; other site 210007002346 hinge residues; other site 210007002347 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 210007002348 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 210007002349 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 210007002350 DNA primase; Validated; Region: dnaG; PRK05667 210007002351 CHC2 zinc finger; Region: zf-CHC2; pfam01807 210007002352 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 210007002353 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 210007002354 active site 210007002355 metal binding site [ion binding]; metal-binding site 210007002356 interdomain interaction site; other site 210007002357 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 210007002358 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 210007002359 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 210007002360 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 210007002361 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 210007002362 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 210007002363 DNA binding residues [nucleotide binding] 210007002364 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 210007002365 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 210007002366 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 210007002367 NADP binding site [chemical binding]; other site 210007002368 active site 210007002369 putative substrate binding site [chemical binding]; other site 210007002370 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 210007002371 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 210007002372 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 210007002373 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 210007002374 Probable Catalytic site; other site 210007002375 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 210007002376 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 210007002377 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 210007002378 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 210007002379 Walker A/P-loop; other site 210007002380 ATP binding site [chemical binding]; other site 210007002381 Q-loop/lid; other site 210007002382 ABC transporter signature motif; other site 210007002383 Walker B; other site 210007002384 D-loop; other site 210007002385 H-loop/switch region; other site 210007002386 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 210007002387 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 210007002388 active site 210007002389 Rhamnan synthesis protein F; Region: RgpF; pfam05045 210007002390 Sulfatase; Region: Sulfatase; pfam00884 210007002391 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 210007002392 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 210007002393 Ligand binding site; other site 210007002394 Putative Catalytic site; other site 210007002395 DXD motif; other site 210007002396 glycosyltransferase, TIGR04182 family; Region: glyco_TIGR04182 210007002397 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 210007002398 Ligand binding site; other site 210007002399 Putative Catalytic site; other site 210007002400 DXD motif; other site 210007002401 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 210007002402 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 210007002403 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 210007002404 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 210007002405 Surface antigen [General function prediction only]; Region: COG3942 210007002406 CHAP domain; Region: CHAP; pfam05257 210007002407 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 210007002408 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 210007002409 active site 210007002410 catalytic tetrad [active] 210007002411 glutathione reductase; Validated; Region: PRK06116 210007002412 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 210007002413 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 210007002414 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 210007002415 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 210007002416 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 210007002417 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 210007002418 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 210007002419 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 210007002420 catalytic residue [active] 210007002421 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 210007002422 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 210007002423 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 210007002424 Ligand Binding Site [chemical binding]; other site 210007002425 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 210007002426 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 210007002427 putative active site [active] 210007002428 putative metal binding site [ion binding]; other site 210007002429 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 210007002430 Coenzyme A binding pocket [chemical binding]; other site 210007002431 Protein of unknown function (DUF1211); Region: DUF1211; pfam06736 210007002432 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 210007002433 Protein of unknown function (DUF464); Region: DUF464; pfam04327 210007002434 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 210007002435 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 210007002436 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 210007002437 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 210007002438 putative NADH binding site [chemical binding]; other site 210007002439 putative active site [active] 210007002440 nudix motif; other site 210007002441 putative metal binding site [ion binding]; other site 210007002442 Transcriptional regulator [Transcription]; Region: LysR; COG0583 210007002443 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 210007002444 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 210007002445 dimerization interface [polypeptide binding]; other site 210007002446 lipoprotein signal peptidase; Provisional; Region: PRK14797 210007002447 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 210007002448 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 210007002449 RNA binding surface [nucleotide binding]; other site 210007002450 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 210007002451 active site 210007002452 Uncharacterized conserved protein [Function unknown]; Region: COG0398 210007002453 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 210007002454 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 210007002455 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 210007002456 active site 210007002457 uracil transporter; Provisional; Region: PRK10720 210007002458 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 210007002459 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 210007002460 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 210007002461 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 210007002462 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 210007002463 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 210007002464 catalytic site [active] 210007002465 subunit interface [polypeptide binding]; other site 210007002466 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 210007002467 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 210007002468 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 210007002469 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 210007002470 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 210007002471 ATP-grasp domain; Region: ATP-grasp_4; cl17255 210007002472 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 210007002473 IMP binding site; other site 210007002474 dimer interface [polypeptide binding]; other site 210007002475 interdomain contacts; other site 210007002476 partial ornithine binding site; other site 210007002477 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 210007002478 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 210007002479 HlyD family secretion protein; Region: HlyD_3; pfam13437 210007002480 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 210007002481 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 210007002482 Walker A/P-loop; other site 210007002483 ATP binding site [chemical binding]; other site 210007002484 Q-loop/lid; other site 210007002485 ABC transporter signature motif; other site 210007002486 Walker B; other site 210007002487 D-loop; other site 210007002488 H-loop/switch region; other site 210007002489 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 210007002490 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 210007002491 FtsX-like permease family; Region: FtsX; pfam02687 210007002492 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 210007002493 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 210007002494 KH domain; Region: KH_4; pfam13083 210007002495 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 210007002496 RimM N-terminal domain; Region: RimM; pfam01782 210007002497 PRC-barrel domain; Region: PRC; pfam05239 210007002498 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 210007002499 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 210007002500 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 210007002501 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 210007002502 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 210007002503 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 210007002504 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 210007002505 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 210007002506 putative substrate binding site [chemical binding]; other site 210007002507 putative ATP binding site [chemical binding]; other site 210007002508 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 210007002509 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 210007002510 active site 210007002511 phosphorylation site [posttranslational modification] 210007002512 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 210007002513 active site 210007002514 P-loop; other site 210007002515 phosphorylation site [posttranslational modification] 210007002516 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 210007002517 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 210007002518 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 210007002519 THF binding site; other site 210007002520 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 210007002521 substrate binding site [chemical binding]; other site 210007002522 THF binding site; other site 210007002523 zinc-binding site [ion binding]; other site 210007002524 bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645 210007002525 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 210007002526 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 210007002527 FAD binding site [chemical binding]; other site 210007002528 Integrase core domain; Region: rve; pfam00665 210007002529 Integrase core domain; Region: rve_2; pfam13333 210007002530 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 210007002531 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 210007002532 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 210007002533 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 210007002534 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 210007002535 Melibiase; Region: Melibiase; pfam02065 210007002536 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 210007002537 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 210007002538 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 210007002539 dimer interface [polypeptide binding]; other site 210007002540 conserved gate region; other site 210007002541 putative PBP binding loops; other site 210007002542 ABC-ATPase subunit interface; other site 210007002543 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 210007002544 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 210007002545 dimer interface [polypeptide binding]; other site 210007002546 conserved gate region; other site 210007002547 putative PBP binding loops; other site 210007002548 ABC-ATPase subunit interface; other site 210007002549 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 210007002550 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 210007002551 active site 210007002552 homodimer interface [polypeptide binding]; other site 210007002553 catalytic site [active] 210007002554 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 210007002555 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 210007002556 Walker A/P-loop; other site 210007002557 ATP binding site [chemical binding]; other site 210007002558 Q-loop/lid; other site 210007002559 ABC transporter signature motif; other site 210007002560 Walker B; other site 210007002561 D-loop; other site 210007002562 H-loop/switch region; other site 210007002563 TOBE domain; Region: TOBE_2; pfam08402 210007002564 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 210007002565 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 210007002566 Ca binding site [ion binding]; other site 210007002567 active site 210007002568 catalytic site [active] 210007002569 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 210007002570 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 210007002571 DNA binding site [nucleotide binding] 210007002572 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 210007002573 putative dimerization interface [polypeptide binding]; other site 210007002574 putative ligand binding site [chemical binding]; other site 210007002575 galactokinase; Provisional; Region: PRK05322 210007002576 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 210007002577 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 210007002578 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 210007002579 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 210007002580 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 210007002581 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 210007002582 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 210007002583 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 210007002584 NAD binding site [chemical binding]; other site 210007002585 homodimer interface [polypeptide binding]; other site 210007002586 active site 210007002587 substrate binding site [chemical binding]; other site 210007002588 Beta-lactamase; Region: Beta-lactamase; pfam00144 210007002589 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 210007002590 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 210007002591 active site 210007002592 type I restriction system adenine methylase (hsdM); Region: hsdM; TIGR00497 210007002593 HsdM N-terminal domain; Region: HsdM_N; pfam12161 210007002594 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 210007002595 S-adenosylmethionine binding site [chemical binding]; other site 210007002596 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 210007002597 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 210007002598 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 210007002599 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 210007002600 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 210007002601 AAA domain; Region: AAA_13; pfam13166 210007002602 addiction module antitoxin, RelB/DinJ family; Region: RelB_DinJ; TIGR02384 210007002603 addiction module toxin, RelE/StbE family; Region: RelE_StbE; TIGR02385 210007002604 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 210007002605 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 210007002606 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 210007002607 ATP binding site [chemical binding]; other site 210007002608 putative Mg++ binding site [ion binding]; other site 210007002609 Protein of unknown function (DUF1149); Region: DUF1149; pfam06619 210007002610 EDD domain protein, DegV family; Region: DegV; TIGR00762 210007002611 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 210007002612 dihydrodipicolinate reductase; Provisional; Region: PRK00048 210007002613 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 210007002614 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 210007002615 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 210007002616 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 210007002617 active site 210007002618 NTP binding site [chemical binding]; other site 210007002619 metal binding triad [ion binding]; metal-binding site 210007002620 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 210007002621 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 210007002622 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 210007002623 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 210007002624 Walker A/P-loop; other site 210007002625 ATP binding site [chemical binding]; other site 210007002626 Q-loop/lid; other site 210007002627 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 210007002628 ABC transporter; Region: ABC_tran_2; pfam12848 210007002629 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 210007002630 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 210007002631 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 210007002632 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 210007002633 Walker A/P-loop; other site 210007002634 ATP binding site [chemical binding]; other site 210007002635 Q-loop/lid; other site 210007002636 ABC transporter signature motif; other site 210007002637 Walker B; other site 210007002638 D-loop; other site 210007002639 H-loop/switch region; other site 210007002640 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 210007002641 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 210007002642 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 210007002643 Walker A/P-loop; other site 210007002644 ATP binding site [chemical binding]; other site 210007002645 Q-loop/lid; other site 210007002646 ABC transporter signature motif; other site 210007002647 Walker B; other site 210007002648 D-loop; other site 210007002649 H-loop/switch region; other site 210007002650 Membrane transport protein; Region: Mem_trans; cl09117 210007002651 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 210007002652 Glycosyl hydrolase family 70; Region: Glyco_hydro_70; pfam02324 210007002653 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 210007002654 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 210007002655 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 210007002656 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 210007002657 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 210007002658 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 210007002659 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 210007002660 glutamate dehydrogenase; Provisional; Region: PRK09414 210007002661 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 210007002662 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 210007002663 NAD(P) binding site [chemical binding]; other site 210007002664 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 210007002665 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 210007002666 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 210007002667 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 210007002668 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 210007002669 active site 210007002670 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 210007002671 Ligand Binding Site [chemical binding]; other site 210007002672 Transcriptional regulators [Transcription]; Region: MarR; COG1846 210007002673 MarR family; Region: MarR_2; pfam12802 210007002674 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 210007002675 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 210007002676 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 210007002677 Walker A/P-loop; other site 210007002678 ATP binding site [chemical binding]; other site 210007002679 Q-loop/lid; other site 210007002680 ABC transporter signature motif; other site 210007002681 Walker B; other site 210007002682 D-loop; other site 210007002683 H-loop/switch region; other site 210007002684 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 210007002685 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 210007002686 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 210007002687 Walker A/P-loop; other site 210007002688 ATP binding site [chemical binding]; other site 210007002689 Q-loop/lid; other site 210007002690 ABC transporter signature motif; other site 210007002691 Walker B; other site 210007002692 D-loop; other site 210007002693 H-loop/switch region; other site 210007002694 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 210007002695 dimer interface [polypeptide binding]; other site 210007002696 catalytic triad [active] 210007002697 peroxidatic and resolving cysteines [active] 210007002698 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 210007002699 synthetase active site [active] 210007002700 NTP binding site [chemical binding]; other site 210007002701 metal binding site [ion binding]; metal-binding site 210007002702 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 210007002703 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 210007002704 active site 210007002705 phosphorylation site [posttranslational modification] 210007002706 intermolecular recognition site; other site 210007002707 dimerization interface [polypeptide binding]; other site 210007002708 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 210007002709 DNA binding site [nucleotide binding] 210007002710 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 210007002711 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 210007002712 dimer interface [polypeptide binding]; other site 210007002713 phosphorylation site [posttranslational modification] 210007002714 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 210007002715 ATP binding site [chemical binding]; other site 210007002716 Mg2+ binding site [ion binding]; other site 210007002717 G-X-G motif; other site 210007002718 Protein of unknown function (DUF1304); Region: DUF1304; cl01533 210007002719 Transcriptional regulator [Transcription]; Region: LysR; COG0583 210007002720 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 210007002721 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 210007002722 dimerization interface [polypeptide binding]; other site 210007002723 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 210007002724 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 210007002725 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 210007002726 substrate binding pocket [chemical binding]; other site 210007002727 membrane-bound complex binding site; other site 210007002728 hinge residues; other site 210007002729 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 210007002730 dimer interface [polypeptide binding]; other site 210007002731 conserved gate region; other site 210007002732 putative PBP binding loops; other site 210007002733 ABC-ATPase subunit interface; other site 210007002734 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 210007002735 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 210007002736 dimer interface [polypeptide binding]; other site 210007002737 conserved gate region; other site 210007002738 putative PBP binding loops; other site 210007002739 ABC-ATPase subunit interface; other site 210007002740 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 210007002741 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 210007002742 Walker A/P-loop; other site 210007002743 ATP binding site [chemical binding]; other site 210007002744 Q-loop/lid; other site 210007002745 ABC transporter signature motif; other site 210007002746 Walker B; other site 210007002747 D-loop; other site 210007002748 H-loop/switch region; other site 210007002749 diphosphomevalonate decarboxylase; Region: PLN02407 210007002750 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 210007002751 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 210007002752 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 210007002753 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 210007002754 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 210007002755 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 210007002756 homotetramer interface [polypeptide binding]; other site 210007002757 FMN binding site [chemical binding]; other site 210007002758 homodimer contacts [polypeptide binding]; other site 210007002759 putative active site [active] 210007002760 putative substrate binding site [chemical binding]; other site 210007002761 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 210007002762 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 210007002763 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 210007002764 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 210007002765 homodimer interface [polypeptide binding]; other site 210007002766 catalytic residues [active] 210007002767 NAD binding site [chemical binding]; other site 210007002768 substrate binding pocket [chemical binding]; other site 210007002769 flexible flap; other site 210007002770 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 210007002771 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 210007002772 dimer interface [polypeptide binding]; other site 210007002773 active site 210007002774 thymidylate synthase; Reviewed; Region: thyA; PRK01827 210007002775 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 210007002776 dimerization interface [polypeptide binding]; other site 210007002777 active site 210007002778 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 210007002779 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 210007002780 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 210007002781 folate binding site [chemical binding]; other site 210007002782 NADP+ binding site [chemical binding]; other site 210007002783 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 210007002784 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 210007002785 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 210007002786 Walker A motif; other site 210007002787 ATP binding site [chemical binding]; other site 210007002788 Walker B motif; other site 210007002789 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 210007002790 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 210007002791 G1 box; other site 210007002792 GTP/Mg2+ binding site [chemical binding]; other site 210007002793 Switch I region; other site 210007002794 G2 box; other site 210007002795 G3 box; other site 210007002796 Switch II region; other site 210007002797 G4 box; other site 210007002798 G5 box; other site 210007002799 S-methylmethionine transporter; Provisional; Region: PRK11387 210007002800 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 210007002801 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 210007002802 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 210007002803 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 210007002804 DNA-binding site [nucleotide binding]; DNA binding site 210007002805 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 210007002806 pyridoxal 5'-phosphate binding site [chemical binding]; other site 210007002807 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 210007002808 dimer interface [polypeptide binding]; other site 210007002809 pyridoxal binding site [chemical binding]; other site 210007002810 ATP binding site [chemical binding]; other site 210007002811 Predicted membrane protein [Function unknown]; Region: COG4720 210007002812 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 210007002813 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 210007002814 Walker A motif; other site 210007002815 ATP binding site [chemical binding]; other site 210007002816 Walker B motif; other site 210007002817 arginine finger; other site 210007002818 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 210007002819 Walker A motif; other site 210007002820 ATP binding site [chemical binding]; other site 210007002821 Walker B motif; other site 210007002822 arginine finger; other site 210007002823 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 210007002824 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 210007002825 23S rRNA interface [nucleotide binding]; other site 210007002826 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 210007002827 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 210007002828 core dimer interface [polypeptide binding]; other site 210007002829 L10 interface [polypeptide binding]; other site 210007002830 L11 interface [polypeptide binding]; other site 210007002831 putative EF-Tu interaction site [polypeptide binding]; other site 210007002832 putative EF-G interaction site [polypeptide binding]; other site 210007002833 Uncharacterized conserved protein [Function unknown]; Region: COG2128 210007002834 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 210007002835 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 210007002836 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 210007002837 active site 210007002838 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 210007002839 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 210007002840 putative active site [active] 210007002841 putative metal binding site [ion binding]; other site 210007002842 homoserine dehydrogenase; Provisional; Region: PRK06349 210007002843 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 210007002844 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 210007002845 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 210007002846 homoserine kinase; Provisional; Region: PRK01212 210007002847 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 210007002848 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 210007002849 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 210007002850 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 210007002851 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 210007002852 homodecamer interface [polypeptide binding]; other site 210007002853 GTP cyclohydrolase I; Provisional; Region: PLN03044 210007002854 active site 210007002855 putative catalytic site residues [active] 210007002856 zinc binding site [ion binding]; other site 210007002857 GTP-CH-I/GFRP interaction surface; other site 210007002858 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 210007002859 dihydropteroate synthase; Region: DHPS; TIGR01496 210007002860 substrate binding pocket [chemical binding]; other site 210007002861 dimer interface [polypeptide binding]; other site 210007002862 inhibitor binding site; inhibition site 210007002863 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 210007002864 homooctamer interface [polypeptide binding]; other site 210007002865 active site 210007002866 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 210007002867 catalytic center binding site [active] 210007002868 ATP binding site [chemical binding]; other site 210007002869 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 210007002870 FAD binding domain; Region: FAD_binding_4; pfam01565 210007002871 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 210007002872 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 210007002873 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 210007002874 Walker A/P-loop; other site 210007002875 ATP binding site [chemical binding]; other site 210007002876 Q-loop/lid; other site 210007002877 ABC transporter signature motif; other site 210007002878 Walker B; other site 210007002879 D-loop; other site 210007002880 H-loop/switch region; other site 210007002881 TOBE domain; Region: TOBE_2; pfam08402 210007002882 sulfate transport protein; Provisional; Region: cysT; CHL00187 210007002883 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 210007002884 dimer interface [polypeptide binding]; other site 210007002885 conserved gate region; other site 210007002886 putative PBP binding loops; other site 210007002887 ABC-ATPase subunit interface; other site 210007002888 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 210007002889 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 210007002890 dimer interface [polypeptide binding]; other site 210007002891 conserved gate region; other site 210007002892 putative PBP binding loops; other site 210007002893 ABC-ATPase subunit interface; other site 210007002894 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 210007002895 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 210007002896 PRD domain; Region: PRD; pfam00874 210007002897 PRD domain; Region: PRD; pfam00874 210007002898 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 210007002899 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 210007002900 active site turn [active] 210007002901 phosphorylation site [posttranslational modification] 210007002902 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 210007002903 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 210007002904 HPr interaction site; other site 210007002905 glycerol kinase (GK) interaction site [polypeptide binding]; other site 210007002906 active site 210007002907 phosphorylation site [posttranslational modification] 210007002908 Predicted peptidase [General function prediction only]; Region: COG4099 210007002909 Predicted peptidase [General function prediction only]; Region: COG4099 210007002910 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 210007002911 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 210007002912 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 210007002913 CHAP domain; Region: CHAP; pfam05257 210007002914 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 210007002915 beta-galactosidase; Region: BGL; TIGR03356 210007002916 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 210007002917 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 210007002918 non-specific DNA binding site [nucleotide binding]; other site 210007002919 salt bridge; other site 210007002920 sequence-specific DNA binding site [nucleotide binding]; other site 210007002921 Collagen binding domain; Region: Collagen_bind; pfam05737 210007002922 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 210007002923 Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154 210007002924 putative active site [active] 210007002925 catalytic site [active] 210007002926 Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160 210007002927 putative active site [active] 210007002928 catalytic site [active] 210007002929 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 210007002930 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 210007002931 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 210007002932 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 210007002933 dimer interface [polypeptide binding]; other site 210007002934 active site 210007002935 catalytic residue [active] 210007002936 ATP cone domain; Region: ATP-cone; pfam03477 210007002937 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 210007002938 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 210007002939 GTP/Mg2+ binding site [chemical binding]; other site 210007002940 G4 box; other site 210007002941 G5 box; other site 210007002942 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 210007002943 G1 box; other site 210007002944 G1 box; other site 210007002945 GTP/Mg2+ binding site [chemical binding]; other site 210007002946 Switch I region; other site 210007002947 G2 box; other site 210007002948 G2 box; other site 210007002949 G3 box; other site 210007002950 G3 box; other site 210007002951 Switch II region; other site 210007002952 Switch II region; other site 210007002953 G5 box; other site 210007002954 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 210007002955 RNA/DNA hybrid binding site [nucleotide binding]; other site 210007002956 active site 210007002957 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 210007002958 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 210007002959 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 210007002960 ABC-ATPase subunit interface; other site 210007002961 dimer interface [polypeptide binding]; other site 210007002962 putative PBP binding regions; other site 210007002963 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 210007002964 ABC-ATPase subunit interface; other site 210007002965 dimer interface [polypeptide binding]; other site 210007002966 putative PBP binding regions; other site 210007002967 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 210007002968 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 210007002969 Walker A/P-loop; other site 210007002970 ATP binding site [chemical binding]; other site 210007002971 Q-loop/lid; other site 210007002972 ABC transporter signature motif; other site 210007002973 Walker B; other site 210007002974 D-loop; other site 210007002975 H-loop/switch region; other site 210007002976 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 210007002977 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 210007002978 putative ligand binding residues [chemical binding]; other site 210007002979 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 210007002980 DNA protecting protein DprA; Region: dprA; TIGR00732 210007002981 DNA topoisomerase I; Validated; Region: PRK05582 210007002982 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 210007002983 active site 210007002984 interdomain interaction site; other site 210007002985 putative metal-binding site [ion binding]; other site 210007002986 nucleotide binding site [chemical binding]; other site 210007002987 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 210007002988 domain I; other site 210007002989 DNA binding groove [nucleotide binding] 210007002990 phosphate binding site [ion binding]; other site 210007002991 domain II; other site 210007002992 domain III; other site 210007002993 nucleotide binding site [chemical binding]; other site 210007002994 catalytic site [active] 210007002995 domain IV; other site 210007002996 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 210007002997 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 210007002998 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 210007002999 Glucose inhibited division protein A; Region: GIDA; pfam01134 210007003000 Glycosyl hydrolase family 70; Region: Glyco_hydro_70; pfam02324 210007003001 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 210007003002 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 210007003003 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 210007003004 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 210007003005 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 210007003006 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 210007003007 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 210007003008 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 210007003009 Glycosyl hydrolase family 70; Region: Glyco_hydro_70; pfam02324 210007003010 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 210007003011 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 210007003012 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 210007003013 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 210007003014 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 210007003015 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 210007003016 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 210007003017 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 210007003018 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 210007003019 Walker A/P-loop; other site 210007003020 ATP binding site [chemical binding]; other site 210007003021 Q-loop/lid; other site 210007003022 ABC transporter signature motif; other site 210007003023 Walker B; other site 210007003024 D-loop; other site 210007003025 H-loop/switch region; other site 210007003026 FtsX-like permease family; Region: FtsX; pfam02687 210007003027 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 210007003028 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 210007003029 active site 210007003030 phosphorylation site [posttranslational modification] 210007003031 intermolecular recognition site; other site 210007003032 dimerization interface [polypeptide binding]; other site 210007003033 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 210007003034 DNA binding site [nucleotide binding] 210007003035 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 210007003036 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 210007003037 ATP binding site [chemical binding]; other site 210007003038 Mg2+ binding site [ion binding]; other site 210007003039 G-X-G motif; other site 210007003040 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 210007003041 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 210007003042 putative active site [active] 210007003043 (T/H)XGH motif; other site 210007003044 triphosphoribosyl-dephospho-CoA synthase CitG; Region: citrate_citG; TIGR03125 210007003045 Transcriptional regulators [Transcription]; Region: GntR; COG1802 210007003046 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 210007003047 DNA-binding site [nucleotide binding]; DNA binding site 210007003048 FCD domain; Region: FCD; pfam07729 210007003049 H+/citrate symporter [Energy production and conversion]; Region: CitM; COG2851 210007003050 Citrate transporter; Region: CitMHS; pfam03600 210007003051 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549 210007003052 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 210007003053 carboxyltransferase (CT) interaction site; other site 210007003054 biotinylation site [posttranslational modification]; other site 210007003055 Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; pfam03977 210007003056 Oxaloacetate decarboxylase, gamma chain; Region: OAD_gamma; cl01458 210007003057 citrate lyase subunit gamma; Provisional; Region: PRK13253 210007003058 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 210007003059 Citrate lyase, alpha subunit (CitF); Region: CitF; pfam04223 210007003060 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 210007003061 2'-(5''-triphosphoribosyl)-3'- dephospho-CoA:apo-citrate lyase; Reviewed; Region: citX; PRK01392 210007003062 oxaloacetate decarboxylase; Provisional; Region: PRK12331 210007003063 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 210007003064 active site 210007003065 catalytic residues [active] 210007003066 metal binding site [ion binding]; metal-binding site 210007003067 homodimer binding site [polypeptide binding]; other site 210007003068 Integrase core domain; Region: rve_2; pfam13333 210007003069 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 210007003070 MarR family; Region: MarR_2; pfam12802 210007003071 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 210007003072 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 210007003073 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 210007003074 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 210007003075 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 210007003076 Helix-turn-helix domain; Region: HTH_16; pfam12645 210007003077 Excisionase from transposon Tn916; Region: Tn916-Xis; pfam09035 210007003078 DNA binding domain of tn916 integrase; Region: Integrase_DNA; pfam02920 210007003079 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 210007003080 Int/Topo IB signature motif; other site 210007003081 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 210007003082 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 210007003083 active site 210007003084 DNA binding site [nucleotide binding] 210007003085 Int/Topo IB signature motif; other site 210007003086 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 210007003087 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 210007003088 Walker A/P-loop; other site 210007003089 ATP binding site [chemical binding]; other site 210007003090 Q-loop/lid; other site 210007003091 ABC transporter signature motif; other site 210007003092 Walker B; other site 210007003093 D-loop; other site 210007003094 H-loop/switch region; other site 210007003095 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 210007003096 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 210007003097 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 210007003098 dimer interface [polypeptide binding]; other site 210007003099 phosphorylation site [posttranslational modification] 210007003100 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 210007003101 ATP binding site [chemical binding]; other site 210007003102 Mg2+ binding site [ion binding]; other site 210007003103 G-X-G motif; other site 210007003104 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 210007003105 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 210007003106 active site 210007003107 phosphorylation site [posttranslational modification] 210007003108 intermolecular recognition site; other site 210007003109 dimerization interface [polypeptide binding]; other site 210007003110 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 210007003111 DNA binding site [nucleotide binding] 210007003112 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 210007003113 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 210007003114 Ligand binding site; other site 210007003115 metal-binding site 210007003116 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 210007003117 malonic semialdehyde reductase; Provisional; Region: PRK10538 210007003118 putative NAD(P) binding site [chemical binding]; other site 210007003119 homotetramer interface [polypeptide binding]; other site 210007003120 homodimer interface [polypeptide binding]; other site 210007003121 active site 210007003122 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 210007003123 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 210007003124 Walker A/P-loop; other site 210007003125 ATP binding site [chemical binding]; other site 210007003126 Q-loop/lid; other site 210007003127 ABC transporter signature motif; other site 210007003128 Walker B; other site 210007003129 D-loop; other site 210007003130 H-loop/switch region; other site 210007003131 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 210007003132 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 210007003133 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 210007003134 active site 210007003135 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 210007003136 ATP-NAD kinase; Region: NAD_kinase; pfam01513 210007003137 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 210007003138 synthetase active site [active] 210007003139 NTP binding site [chemical binding]; other site 210007003140 metal binding site [ion binding]; metal-binding site 210007003141 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 210007003142 putative active site [active] 210007003143 putative metal binding residues [ion binding]; other site 210007003144 signature motif; other site 210007003145 putative triphosphate binding site [ion binding]; other site 210007003146 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458 210007003147 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 210007003148 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 210007003149 active site 210007003150 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 210007003151 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 210007003152 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 210007003153 catalytic residue [active] 210007003154 Putative amino acid metabolism; Region: DUF1831; pfam08866 210007003155 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 210007003156 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 210007003157 CoA binding domain; Region: CoA_binding; pfam02629 210007003158 Peptidase C26; Region: Peptidase_C26; pfam07722 210007003159 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 210007003160 catalytic triad [active] 210007003161 hypothetical protein; Reviewed; Region: PRK00024 210007003162 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 210007003163 MPN+ (JAMM) motif; other site 210007003164 Zinc-binding site [ion binding]; other site 210007003165 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 210007003166 signal recognition particle protein; Provisional; Region: PRK10867 210007003167 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 210007003168 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 210007003169 P loop; other site 210007003170 GTP binding site [chemical binding]; other site 210007003171 Signal peptide binding domain; Region: SRP_SPB; pfam02978 210007003172 putative DNA-binding protein; Validated; Region: PRK00118 210007003173 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 210007003174 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 210007003175 dimer interface [polypeptide binding]; other site 210007003176 conserved gate region; other site 210007003177 putative PBP binding loops; other site 210007003178 ABC-ATPase subunit interface; other site 210007003179 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 210007003180 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 210007003181 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 210007003182 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 210007003183 Walker A/P-loop; other site 210007003184 ATP binding site [chemical binding]; other site 210007003185 Q-loop/lid; other site 210007003186 ABC transporter signature motif; other site 210007003187 Walker B; other site 210007003188 D-loop; other site 210007003189 H-loop/switch region; other site 210007003190 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 210007003191 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 210007003192 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 210007003193 DNA-binding site [nucleotide binding]; DNA binding site 210007003194 TrkA-C domain; Region: TrkA_C; pfam02080 210007003195 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 210007003196 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 210007003197 DNA-binding site [nucleotide binding]; DNA binding site 210007003198 UTRA domain; Region: UTRA; pfam07702 210007003199 GMP synthase; Reviewed; Region: guaA; PRK00074 210007003200 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 210007003201 AMP/PPi binding site [chemical binding]; other site 210007003202 candidate oxyanion hole; other site 210007003203 catalytic triad [active] 210007003204 potential glutamine specificity residues [chemical binding]; other site 210007003205 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 210007003206 ATP Binding subdomain [chemical binding]; other site 210007003207 Dimerization subdomain; other site 210007003208 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 210007003209 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 210007003210 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 210007003211 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 210007003212 Walker A/P-loop; other site 210007003213 ATP binding site [chemical binding]; other site 210007003214 Q-loop/lid; other site 210007003215 ABC transporter signature motif; other site 210007003216 Walker B; other site 210007003217 D-loop; other site 210007003218 H-loop/switch region; other site 210007003219 LytTr DNA-binding domain; Region: LytTR; pfam04397 210007003220 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 210007003221 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 210007003222 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 210007003223 Coenzyme A binding pocket [chemical binding]; other site 210007003224 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 210007003225 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 210007003226 Potassium binding sites [ion binding]; other site 210007003227 Cesium cation binding sites [ion binding]; other site 210007003228 phosphopantothenate--cysteine ligase; Validated; Region: PRK06732 210007003229 phosphopantothenoylcysteine decarboxylase, streptococcal; Region: coaC_strep; TIGR02113 210007003230 Flavoprotein; Region: Flavoprotein; pfam02441 210007003231 Predicted membrane protein [Function unknown]; Region: COG4684 210007003232 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 210007003233 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 210007003234 active site 210007003235 substrate binding site [chemical binding]; other site 210007003236 metal binding site [ion binding]; metal-binding site 210007003237 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 210007003238 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 210007003239 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 210007003240 Walker A/P-loop; other site 210007003241 ATP binding site [chemical binding]; other site 210007003242 Q-loop/lid; other site 210007003243 ABC transporter signature motif; other site 210007003244 Walker B; other site 210007003245 D-loop; other site 210007003246 H-loop/switch region; other site 210007003247 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 210007003248 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 210007003249 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 210007003250 Walker A/P-loop; other site 210007003251 ATP binding site [chemical binding]; other site 210007003252 Q-loop/lid; other site 210007003253 ABC transporter signature motif; other site 210007003254 Walker B; other site 210007003255 D-loop; other site 210007003256 H-loop/switch region; other site 210007003257 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 210007003258 N-acetyl-D-glucosamine binding site [chemical binding]; other site 210007003259 catalytic residue [active] 210007003260 37-kD nucleoid-associated bacterial protein; Region: NA37; pfam04245 210007003261 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 210007003262 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 210007003263 dimer interface [polypeptide binding]; other site 210007003264 active site 210007003265 glycine-pyridoxal phosphate binding site [chemical binding]; other site 210007003266 folate binding site [chemical binding]; other site 210007003267 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 210007003268 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 210007003269 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 210007003270 S-adenosylmethionine binding site [chemical binding]; other site 210007003271 peptide chain release factor 1; Validated; Region: prfA; PRK00591 210007003272 This domain is found in peptide chain release factors; Region: PCRF; smart00937 210007003273 RF-1 domain; Region: RF-1; pfam00472 210007003274 thymidine kinase; Provisional; Region: PRK04296 210007003275 4-oxalocrotonate tautomerase; Provisional; Region: PRK02289 210007003276 active site 1 [active] 210007003277 dimer interface [polypeptide binding]; other site 210007003278 hexamer interface [polypeptide binding]; other site 210007003279 active site 2 [active] 210007003280 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 210007003281 ApbE family; Region: ApbE; pfam02424 210007003282 Predicted flavoprotein [General function prediction only]; Region: COG0431 210007003283 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 210007003284 Predicted flavoprotein [General function prediction only]; Region: COG0431 210007003285 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 210007003286 PAS domain; Region: PAS_10; pfam13596 210007003287 putative cross-wall-targeting lipoprotein signal; Region: strep_RK_lipo; TIGR03726 210007003288 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 210007003289 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 210007003290 FtsX-like permease family; Region: FtsX; pfam02687 210007003291 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 210007003292 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 210007003293 Walker A/P-loop; other site 210007003294 ATP binding site [chemical binding]; other site 210007003295 Q-loop/lid; other site 210007003296 ABC transporter signature motif; other site 210007003297 Walker B; other site 210007003298 D-loop; other site 210007003299 H-loop/switch region; other site 210007003300 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 210007003301 dimer interface [polypeptide binding]; other site 210007003302 conserved gate region; other site 210007003303 ABC-ATPase subunit interface; other site 210007003304 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 210007003305 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 210007003306 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 210007003307 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 210007003308 Walker A/P-loop; other site 210007003309 ATP binding site [chemical binding]; other site 210007003310 Q-loop/lid; other site 210007003311 ABC transporter signature motif; other site 210007003312 Walker B; other site 210007003313 D-loop; other site 210007003314 H-loop/switch region; other site 210007003315 Transcriptional regulators [Transcription]; Region: MarR; COG1846 210007003316 MarR family; Region: MarR_2; pfam12802 210007003317 Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243 210007003318 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 210007003319 putative NAD(P) binding site [chemical binding]; other site 210007003320 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 210007003321 6-phospho-beta-glucosidase; Reviewed; Region: arb; PRK09593 210007003322 beta-galactosidase; Region: BGL; TIGR03356 210007003323 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 210007003324 catalytic core [active] 210007003325 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 210007003326 catalytic core [active] 210007003327 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 210007003328 catalytic core [active] 210007003329 NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841 210007003330 active site 210007003331 catalytic triad [active] 210007003332 oxyanion hole [active] 210007003333 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 210007003334 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 210007003335 active site 210007003336 motif I; other site 210007003337 motif II; other site 210007003338 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 210007003339 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 210007003340 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 210007003341 Predicted secreted protein [Function unknown]; Region: COG4086 210007003342 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 210007003343 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 210007003344 putative metal binding site [ion binding]; other site 210007003345 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 210007003346 active site 210007003347 catalytic site [active] 210007003348 DNA gyrase subunit A; Validated; Region: PRK05560 210007003349 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 210007003350 CAP-like domain; other site 210007003351 active site 210007003352 primary dimer interface [polypeptide binding]; other site 210007003353 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 210007003354 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 210007003355 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 210007003356 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 210007003357 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 210007003358 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 210007003359 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 210007003360 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 210007003361 tetramer (dimer of dimers) interface [polypeptide binding]; other site 210007003362 NAD binding site [chemical binding]; other site 210007003363 dimer interface [polypeptide binding]; other site 210007003364 substrate binding site [chemical binding]; other site 210007003365 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 210007003366 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 210007003367 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 210007003368 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 210007003369 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 210007003370 TM-ABC transporter signature motif; other site 210007003371 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 210007003372 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 210007003373 TM-ABC transporter signature motif; other site 210007003374 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 210007003375 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 210007003376 Walker A/P-loop; other site 210007003377 ATP binding site [chemical binding]; other site 210007003378 Q-loop/lid; other site 210007003379 ABC transporter signature motif; other site 210007003380 Walker B; other site 210007003381 D-loop; other site 210007003382 H-loop/switch region; other site 210007003383 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 210007003384 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 210007003385 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 210007003386 ligand binding site [chemical binding]; other site 210007003387 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 210007003388 active site 210007003389 catalytic motif [active] 210007003390 Zn binding site [ion binding]; other site 210007003391 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 210007003392 intersubunit interface [polypeptide binding]; other site 210007003393 active site 210007003394 catalytic residue [active] 210007003395 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 210007003396 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 210007003397 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 210007003398 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 210007003399 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 210007003400 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 210007003401 S-adenosylmethionine binding site [chemical binding]; other site 210007003402 pantothenate kinase; Provisional; Region: PRK05439 210007003403 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 210007003404 ATP-binding site [chemical binding]; other site 210007003405 CoA-binding site [chemical binding]; other site 210007003406 Mg2+-binding site [ion binding]; other site 210007003407 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 210007003408 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 210007003409 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 210007003410 dimer interface [polypeptide binding]; other site 210007003411 phosphorylation site [posttranslational modification] 210007003412 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 210007003413 ATP binding site [chemical binding]; other site 210007003414 Mg2+ binding site [ion binding]; other site 210007003415 G-X-G motif; other site 210007003416 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 210007003417 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 210007003418 active site 210007003419 phosphorylation site [posttranslational modification] 210007003420 intermolecular recognition site; other site 210007003421 dimerization interface [polypeptide binding]; other site 210007003422 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 210007003423 DNA binding site [nucleotide binding] 210007003424 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 210007003425 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 210007003426 Zn binding site [ion binding]; other site 210007003427 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 210007003428 PhoU domain; Region: PhoU; pfam01895 210007003429 PhoU domain; Region: PhoU; pfam01895 210007003430 phosphate transporter ATP-binding protein; Provisional; Region: PRK14239 210007003431 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 210007003432 Walker A/P-loop; other site 210007003433 ATP binding site [chemical binding]; other site 210007003434 Q-loop/lid; other site 210007003435 ABC transporter signature motif; other site 210007003436 Walker B; other site 210007003437 D-loop; other site 210007003438 H-loop/switch region; other site 210007003439 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 210007003440 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 210007003441 Walker A/P-loop; other site 210007003442 ATP binding site [chemical binding]; other site 210007003443 Q-loop/lid; other site 210007003444 ABC transporter signature motif; other site 210007003445 Walker B; other site 210007003446 D-loop; other site 210007003447 H-loop/switch region; other site 210007003448 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 210007003449 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 210007003450 dimer interface [polypeptide binding]; other site 210007003451 conserved gate region; other site 210007003452 putative PBP binding loops; other site 210007003453 ABC-ATPase subunit interface; other site 210007003454 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 210007003455 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 210007003456 dimer interface [polypeptide binding]; other site 210007003457 conserved gate region; other site 210007003458 putative PBP binding loops; other site 210007003459 ABC-ATPase subunit interface; other site 210007003460 PBP superfamily domain; Region: PBP_like_2; cl17296 210007003461 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 210007003462 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 210007003463 S-adenosylmethionine binding site [chemical binding]; other site 210007003464 Uncharacterized conserved protein [Function unknown]; Region: COG3270 210007003465 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 210007003466 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 210007003467 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 210007003468 active site 210007003469 hypothetical protein; Provisional; Region: PRK04387 210007003470 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 210007003471 ArsC family; Region: ArsC; pfam03960 210007003472 putative catalytic residues [active] 210007003473 thiol/disulfide switch; other site 210007003474 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 210007003475 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 210007003476 active site 210007003477 Riboflavin kinase; Region: Flavokinase; smart00904 210007003478 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 210007003479 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 210007003480 RNA binding site [nucleotide binding]; other site 210007003481 active site 210007003482 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 210007003483 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 210007003484 dimer interface [polypeptide binding]; other site 210007003485 phosphorylation site [posttranslational modification] 210007003486 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 210007003487 ATP binding site [chemical binding]; other site 210007003488 Mg2+ binding site [ion binding]; other site 210007003489 G-X-G motif; other site 210007003490 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 210007003491 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 210007003492 active site 210007003493 phosphorylation site [posttranslational modification] 210007003494 intermolecular recognition site; other site 210007003495 dimerization interface [polypeptide binding]; other site 210007003496 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 210007003497 DNA binding site [nucleotide binding] 210007003498 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 210007003499 ABC transporter; Region: ABC_tran; pfam00005 210007003500 Q-loop/lid; other site 210007003501 ABC transporter signature motif; other site 210007003502 Walker B; other site 210007003503 D-loop; other site 210007003504 H-loop/switch region; other site 210007003505 lantibiotic protection ABC transporter permease subunit, MutG family; Region: lanti_perm_MutG; TIGR03733 210007003506 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 210007003507 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 210007003508 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 210007003509 Uncharacterized conserved protein [Function unknown]; Region: COG2461 210007003510 Family of unknown function (DUF438); Region: DUF438; pfam04282 210007003511 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 210007003512 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 210007003513 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 210007003514 Coenzyme A binding pocket [chemical binding]; other site 210007003515 Sir2-like: Prokaryotic group of uncharacterized Sir2-like proteins which lack certain key catalytic residues and conserved zinc binding cysteines; and are members of the SIR2 superfamily of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIR2-like; cd01406 210007003516 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 210007003517 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 210007003518 Abortive infection C-terminus; Region: Abi_C; pfam14355 210007003519 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 210007003520 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 210007003521 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 210007003522 Walker A/P-loop; other site 210007003523 ATP binding site [chemical binding]; other site 210007003524 Q-loop/lid; other site 210007003525 ABC transporter signature motif; other site 210007003526 Walker B; other site 210007003527 D-loop; other site 210007003528 H-loop/switch region; other site 210007003529 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 210007003530 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 210007003531 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 210007003532 Walker A/P-loop; other site 210007003533 ATP binding site [chemical binding]; other site 210007003534 Q-loop/lid; other site 210007003535 ABC transporter signature motif; other site 210007003536 Walker B; other site 210007003537 D-loop; other site 210007003538 H-loop/switch region; other site 210007003539 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 210007003540 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 210007003541 FtsX-like permease family; Region: FtsX; pfam02687 210007003542 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 210007003543 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 210007003544 FtsX-like permease family; Region: FtsX; pfam02687 210007003545 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 210007003546 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 210007003547 Walker A/P-loop; other site 210007003548 ATP binding site [chemical binding]; other site 210007003549 Q-loop/lid; other site 210007003550 ABC transporter signature motif; other site 210007003551 Walker B; other site 210007003552 D-loop; other site 210007003553 H-loop/switch region; other site 210007003554 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 210007003555 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 210007003556 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 210007003557 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 210007003558 catalytic residues [active] 210007003559 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 210007003560 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 210007003561 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 210007003562 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 210007003563 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 210007003564 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 210007003565 homodimer interface [polypeptide binding]; other site 210007003566 substrate-cofactor binding pocket; other site 210007003567 pyridoxal 5'-phosphate binding site [chemical binding]; other site 210007003568 catalytic residue [active] 210007003569 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 210007003570 Part of AAA domain; Region: AAA_19; pfam13245 210007003571 Family description; Region: UvrD_C_2; pfam13538 210007003572 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 210007003573 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 210007003574 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 210007003575 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 210007003576 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 210007003577 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 210007003578 substrate binding pocket [chemical binding]; other site 210007003579 membrane-bound complex binding site; other site 210007003580 hinge residues; other site 210007003581 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 210007003582 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 210007003583 Walker A/P-loop; other site 210007003584 ATP binding site [chemical binding]; other site 210007003585 Q-loop/lid; other site 210007003586 ABC transporter signature motif; other site 210007003587 Walker B; other site 210007003588 D-loop; other site 210007003589 H-loop/switch region; other site 210007003590 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 210007003591 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 210007003592 dimer interface [polypeptide binding]; other site 210007003593 conserved gate region; other site 210007003594 ABC-ATPase subunit interface; other site 210007003595 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 210007003596 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 210007003597 PhnA protein; Region: PhnA; pfam03831 210007003598 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 210007003599 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 210007003600 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 210007003601 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 210007003602 active site 210007003603 phosphorylation site [posttranslational modification] 210007003604 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 210007003605 HTH domain; Region: HTH_11; pfam08279 210007003606 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 210007003607 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 210007003608 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 210007003609 active site 210007003610 P-loop; other site 210007003611 phosphorylation site [posttranslational modification] 210007003612 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 210007003613 active site 210007003614 P-loop; other site 210007003615 phosphorylation site [posttranslational modification] 210007003616 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 210007003617 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 210007003618 glutaminase active site [active] 210007003619 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 210007003620 dimer interface [polypeptide binding]; other site 210007003621 active site 210007003622 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 210007003623 dimer interface [polypeptide binding]; other site 210007003624 active site 210007003625 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 210007003626 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 210007003627 Predicted membrane protein [Function unknown]; Region: COG2261 210007003628 pyruvate kinase; Provisional; Region: PRK05826 210007003629 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 210007003630 domain interfaces; other site 210007003631 active site 210007003632 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 210007003633 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 210007003634 active site 210007003635 ADP/pyrophosphate binding site [chemical binding]; other site 210007003636 dimerization interface [polypeptide binding]; other site 210007003637 allosteric effector site; other site 210007003638 fructose-1,6-bisphosphate binding site; other site 210007003639 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279 210007003640 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 210007003641 active site 210007003642 PHP Thumb interface [polypeptide binding]; other site 210007003643 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 210007003644 generic binding surface II; other site 210007003645 generic binding surface I; other site 210007003646 Predicted transcriptional regulators [Transcription]; Region: COG1725 210007003647 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 210007003648 DNA-binding site [nucleotide binding]; DNA binding site 210007003649 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 210007003650 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 210007003651 Walker A/P-loop; other site 210007003652 ATP binding site [chemical binding]; other site 210007003653 Q-loop/lid; other site 210007003654 ABC transporter signature motif; other site 210007003655 Walker B; other site 210007003656 D-loop; other site 210007003657 H-loop/switch region; other site 210007003658 Domain of Unknown Function with PDB structure (DUF3862); Region: DUF3862; pfam12978 210007003659 Uncharacterized conserved protein [Function unknown]; Region: COG0398 210007003660 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 210007003661 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 210007003662 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 210007003663 RNA binding site [nucleotide binding]; other site 210007003664 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 210007003665 RNA binding site [nucleotide binding]; other site 210007003666 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 210007003667 RNA binding site [nucleotide binding]; other site 210007003668 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 210007003669 RNA binding site [nucleotide binding]; other site 210007003670 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 210007003671 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 210007003672 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 210007003673 homodimer interface [polypeptide binding]; other site 210007003674 substrate-cofactor binding pocket; other site 210007003675 catalytic residue [active] 210007003676 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 210007003677 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 210007003678 CAP-like domain; other site 210007003679 active site 210007003680 primary dimer interface [polypeptide binding]; other site 210007003681 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 210007003682 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 210007003683 metal binding triad [ion binding]; metal-binding site 210007003684 Fic/DOC family; Region: Fic; cl00960 210007003685 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 210007003686 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 210007003687 Mg2+ binding site [ion binding]; other site 210007003688 G-X-G motif; other site 210007003689 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 210007003690 anchoring element; other site 210007003691 dimer interface [polypeptide binding]; other site 210007003692 ATP binding site [chemical binding]; other site 210007003693 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 210007003694 active site 210007003695 putative metal-binding site [ion binding]; other site 210007003696 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 210007003697 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 210007003698 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408 210007003699 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 210007003700 putative active site [active] 210007003701 putative metal binding site [ion binding]; other site 210007003702 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 210007003703 dihydroorotase; Validated; Region: pyrC; PRK09357 210007003704 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 210007003705 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 210007003706 active site 210007003707 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 210007003708 ligand binding site [chemical binding]; other site 210007003709 active site 210007003710 UGI interface [polypeptide binding]; other site 210007003711 catalytic site [active] 210007003712 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 210007003713 dimer interface [polypeptide binding]; other site 210007003714 conserved gate region; other site 210007003715 putative PBP binding loops; other site 210007003716 ABC-ATPase subunit interface; other site 210007003717 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 210007003718 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 210007003719 substrate binding pocket [chemical binding]; other site 210007003720 membrane-bound complex binding site; other site 210007003721 hinge residues; other site 210007003722 amidase; Provisional; Region: PRK06529 210007003723 Amidase; Region: Amidase; cl11426 210007003724 Protein of unknown function (DUF419); Region: DUF419; pfam04237 210007003725 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 210007003726 substrate binding site [chemical binding]; other site 210007003727 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 210007003728 active site 210007003729 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 210007003730 active site 210007003731 dimer interface [polypeptide binding]; other site 210007003732 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 210007003733 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 210007003734 heterodimer interface [polypeptide binding]; other site 210007003735 active site 210007003736 FMN binding site [chemical binding]; other site 210007003737 homodimer interface [polypeptide binding]; other site 210007003738 substrate binding site [chemical binding]; other site 210007003739 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 210007003740 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 210007003741 FAD binding pocket [chemical binding]; other site 210007003742 FAD binding motif [chemical binding]; other site 210007003743 phosphate binding motif [ion binding]; other site 210007003744 beta-alpha-beta structure motif; other site 210007003745 NAD binding pocket [chemical binding]; other site 210007003746 Iron coordination center [ion binding]; other site 210007003747 Transcriptional regulator [Transcription]; Region: LysR; COG0583 210007003748 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 210007003749 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 210007003750 dimerization interface [polypeptide binding]; other site 210007003751 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl09873 210007003752 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 210007003753 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 210007003754 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 210007003755 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 210007003756 catalytic triad [active] 210007003757 purine nucleoside phosphorylase; Provisional; Region: PRK08202 210007003758 Protein of unknown function (DUF1643); Region: DUF1643; pfam07799 210007003759 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 210007003760 phosphopentomutase; Provisional; Region: PRK05362 210007003761 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 210007003762 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 210007003763 tetramer (dimer of dimers) interface [polypeptide binding]; other site 210007003764 active site 210007003765 dimer interface [polypeptide binding]; other site 210007003766 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 210007003767 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 210007003768 trmE is a tRNA modification GTPase; Region: trmE; cd04164 210007003769 G1 box; other site 210007003770 GTP/Mg2+ binding site [chemical binding]; other site 210007003771 Switch I region; other site 210007003772 G2 box; other site 210007003773 Switch II region; other site 210007003774 G3 box; other site 210007003775 G4 box; other site 210007003776 G5 box; other site 210007003777 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 210007003778 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 210007003779 SnoaL-like domain; Region: SnoaL_2; pfam12680 210007003780 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 210007003781 putative uracil binding site [chemical binding]; other site 210007003782 putative active site [active] 210007003783 dipeptidase PepV; Reviewed; Region: PRK07318 210007003784 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 210007003785 active site 210007003786 metal binding site [ion binding]; metal-binding site 210007003787 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 210007003788 dimer interface [polypeptide binding]; other site 210007003789 FMN binding site [chemical binding]; other site 210007003790 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 210007003791 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 210007003792 GIY-YIG motif/motif A; other site 210007003793 active site 210007003794 catalytic site [active] 210007003795 putative DNA binding site [nucleotide binding]; other site 210007003796 metal binding site [ion binding]; metal-binding site 210007003797 UvrB/uvrC motif; Region: UVR; pfam02151 210007003798 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 210007003799 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; pfam06772 210007003800 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 210007003801 active site 210007003802 motif I; other site 210007003803 motif II; other site 210007003804 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 210007003805 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 210007003806 enolase; Provisional; Region: eno; PRK00077 210007003807 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 210007003808 dimer interface [polypeptide binding]; other site 210007003809 metal binding site [ion binding]; metal-binding site 210007003810 substrate binding pocket [chemical binding]; other site 210007003811 Protein of unknown function (DUF2681); Region: DUF2681; pfam10883 210007003812 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 210007003813 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 210007003814 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 210007003815 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 210007003816 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 210007003817 Coenzyme A binding pocket [chemical binding]; other site 210007003818 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 210007003819 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 210007003820 motif II; other site 210007003821 Domain of unknown function (DUF4325); Region: DUF4325; pfam14213 210007003822 Zeta toxin; Region: Zeta_toxin; pfam06414 210007003823 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 210007003824 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 210007003825 DivIVA protein; Region: DivIVA; pfam05103 210007003826 DivIVA domain; Region: DivI1A_domain; TIGR03544 210007003827 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 210007003828 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 210007003829 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 210007003830 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 210007003831 substrate binding site [chemical binding]; other site 210007003832 glutamase interaction surface [polypeptide binding]; other site 210007003833 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 210007003834 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 210007003835 catalytic residues [active] 210007003836 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 210007003837 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 210007003838 putative active site [active] 210007003839 oxyanion strand; other site 210007003840 catalytic triad [active] 210007003841 Protein of unknown function (DUF2568); Region: DUF2568; pfam10823 210007003842 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 210007003843 putative active site pocket [active] 210007003844 4-fold oligomerization interface [polypeptide binding]; other site 210007003845 metal binding residues [ion binding]; metal-binding site 210007003846 3-fold/trimer interface [polypeptide binding]; other site 210007003847 phosphoserine phosphatase SerB; Region: serB; TIGR00338 210007003848 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 210007003849 motif II; other site 210007003850 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 210007003851 histidinol dehydrogenase; Region: hisD; TIGR00069 210007003852 NAD binding site [chemical binding]; other site 210007003853 dimerization interface [polypeptide binding]; other site 210007003854 product binding site; other site 210007003855 substrate binding site [chemical binding]; other site 210007003856 zinc binding site [ion binding]; other site 210007003857 catalytic residues [active] 210007003858 ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686 210007003859 ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040 210007003860 ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443 210007003861 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 210007003862 dimer interface [polypeptide binding]; other site 210007003863 motif 1; other site 210007003864 active site 210007003865 motif 2; other site 210007003866 motif 3; other site 210007003867 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 210007003868 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 210007003869 pyridoxal 5'-phosphate binding site [chemical binding]; other site 210007003870 homodimer interface [polypeptide binding]; other site 210007003871 catalytic residue [active] 210007003872 septation ring formation regulator EzrA; Provisional; Region: PRK04778 210007003873 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 210007003874 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 210007003875 Mg2+ binding site [ion binding]; other site 210007003876 G-X-G motif; other site 210007003877 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 210007003878 anchoring element; other site 210007003879 dimer interface [polypeptide binding]; other site 210007003880 ATP binding site [chemical binding]; other site 210007003881 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 210007003882 active site 210007003883 putative metal-binding site [ion binding]; other site 210007003884 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 210007003885 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 210007003886 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 210007003887 motif II; other site 210007003888 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 210007003889 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 210007003890 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 210007003891 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 210007003892 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 210007003893 NADH(P)-binding; Region: NAD_binding_10; pfam13460 210007003894 NAD(P) binding site [chemical binding]; other site 210007003895 active site 210007003896 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 210007003897 Major Facilitator Superfamily; Region: MFS_1; pfam07690 210007003898 putative substrate translocation pore; other site 210007003899 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 210007003900 DNA binding residues [nucleotide binding] 210007003901 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 210007003902 putative dimer interface [polypeptide binding]; other site 210007003903 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 210007003904 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 210007003905 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 210007003906 putative Cl- selectivity filter; other site 210007003907 putative pore gating glutamate residue; other site 210007003908 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 210007003909 ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682 210007003910 putative Cl- selectivity filter; other site 210007003911 putative pore gating glutamate residue; other site 210007003912 hypothetical protein; Provisional; Region: PRK07248 210007003913 Uncharacterized conserved protein [Function unknown]; Region: COG0398 210007003914 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 210007003915 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 210007003916 FeS assembly protein SufB; Region: sufB; TIGR01980 210007003917 flavodoxin; Validated; Region: PRK07308 210007003918 adenosine deaminase; Provisional; Region: PRK09358 210007003919 active site 210007003920 putative S-transferase; Provisional; Region: PRK11752 210007003921 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 210007003922 C-terminal domain interface [polypeptide binding]; other site 210007003923 GSH binding site (G-site) [chemical binding]; other site 210007003924 dimer interface [polypeptide binding]; other site 210007003925 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 210007003926 dimer interface [polypeptide binding]; other site 210007003927 N-terminal domain interface [polypeptide binding]; other site 210007003928 active site 210007003929 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 210007003930 DHH family; Region: DHH; pfam01368 210007003931 DHHA1 domain; Region: DHHA1; pfam02272 210007003932 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 210007003933 Cupin domain; Region: Cupin_2; cl17218 210007003934 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 210007003935 Methyltransferase domain; Region: Methyltransf_31; pfam13847 210007003936 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 210007003937 S-adenosylmethionine binding site [chemical binding]; other site 210007003938 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 210007003939 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 210007003940 metal binding site [ion binding]; metal-binding site 210007003941 YodA lipocalin-like domain; Region: YodA; pfam09223 210007003942 Peptidase family C69; Region: Peptidase_C69; pfam03577 210007003943 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 210007003944 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 210007003945 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 210007003946 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 210007003947 dimer interface [polypeptide binding]; other site 210007003948 phosphate binding site [ion binding]; other site 210007003949 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 210007003950 Protein of unknown function (DUF1003); Region: DUF1003; pfam06210 210007003951 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 210007003952 homotrimer interaction site [polypeptide binding]; other site 210007003953 putative active site [active] 210007003954 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 210007003955 Glycerol dehydrogenase-like; Region: GlyDH-like2; cd08171 210007003956 putative active site [active] 210007003957 metal binding site [ion binding]; metal-binding site 210007003958 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 210007003959 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 210007003960 putative dimer interface [polypeptide binding]; other site 210007003961 putative anticodon binding site; other site 210007003962 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 210007003963 homodimer interface [polypeptide binding]; other site 210007003964 motif 1; other site 210007003965 motif 2; other site 210007003966 active site 210007003967 motif 3; other site 210007003968 aspartate aminotransferase; Provisional; Region: PRK05764 210007003969 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 210007003970 pyridoxal 5'-phosphate binding site [chemical binding]; other site 210007003971 homodimer interface [polypeptide binding]; other site 210007003972 catalytic residue [active] 210007003973 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK07246 210007003974 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 210007003975 active site 210007003976 catalytic site [active] 210007003977 substrate binding site [chemical binding]; other site 210007003978 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 210007003979 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 210007003980 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 210007003981 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13540 210007003982 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 210007003983 Walker A/P-loop; other site 210007003984 ATP binding site [chemical binding]; other site 210007003985 Q-loop/lid; other site 210007003986 ABC transporter signature motif; other site 210007003987 Walker B; other site 210007003988 D-loop; other site 210007003989 H-loop/switch region; other site 210007003990 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 210007003991 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 210007003992 acetoin reductase; Validated; Region: PRK08643 210007003993 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 210007003994 NAD binding site [chemical binding]; other site 210007003995 homotetramer interface [polypeptide binding]; other site 210007003996 homodimer interface [polypeptide binding]; other site 210007003997 active site 210007003998 substrate binding site [chemical binding]; other site 210007003999 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 210007004000 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 210007004001 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 210007004002 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 210007004003 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 210007004004 Walker A/P-loop; other site 210007004005 ATP binding site [chemical binding]; other site 210007004006 Q-loop/lid; other site 210007004007 ABC transporter signature motif; other site 210007004008 Walker B; other site 210007004009 D-loop; other site 210007004010 H-loop/switch region; other site 210007004011 PCRF domain; Region: PCRF; pfam03462 210007004012 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 210007004013 RF-1 domain; Region: RF-1; pfam00472 210007004014 epoxyqueuosine reductase; Region: TIGR00276 210007004015 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 210007004016 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 210007004017 Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612 210007004018 Transposase; Region: DDE_Tnp_ISL3; pfam01610 210007004019 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 210007004020 Transposase; Region: DDE_Tnp_ISL3; pfam01610 210007004021 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 210007004022 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 210007004023 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 210007004024 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 210007004025 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 210007004026 FMN binding site [chemical binding]; other site 210007004027 substrate binding site [chemical binding]; other site 210007004028 putative catalytic residue [active] 210007004029 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 210007004030 Acyl transferase domain; Region: Acyl_transf_1; cl08282 210007004031 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 210007004032 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 210007004033 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 210007004034 H+ Antiporter protein; Region: 2A0121; TIGR00900 210007004035 putative substrate translocation pore; other site 210007004036 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 210007004037 Condensation domain; Region: Condensation; pfam00668 210007004038 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 210007004039 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 210007004040 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 210007004041 acyl-activating enzyme (AAE) consensus motif; other site 210007004042 AMP binding site [chemical binding]; other site 210007004043 active site 210007004044 CoA binding site [chemical binding]; other site 210007004045 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 210007004046 thioester reductase domain; Region: Thioester-redct; TIGR01746 210007004047 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 210007004048 NAD(P) binding site [chemical binding]; other site 210007004049 active site 210007004050 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 210007004051 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 210007004052 acyl-activating enzyme (AAE) consensus motif; other site 210007004053 AMP binding site [chemical binding]; other site 210007004054 active site 210007004055 CoA binding site [chemical binding]; other site 210007004056 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 210007004057 Condensation domain; Region: Condensation; pfam00668 210007004058 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 210007004059 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 210007004060 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 210007004061 acyl-activating enzyme (AAE) consensus motif; other site 210007004062 AMP binding site [chemical binding]; other site 210007004063 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 210007004064 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 210007004065 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 210007004066 acyl-activating enzyme (AAE) consensus motif; other site 210007004067 AMP binding site [chemical binding]; other site 210007004068 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 210007004069 Condensation domain; Region: Condensation; pfam00668 210007004070 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 210007004071 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 210007004072 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 210007004073 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 210007004074 acyl-activating enzyme (AAE) consensus motif; other site 210007004075 AMP binding site [chemical binding]; other site 210007004076 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 210007004077 Condensation domain; Region: Condensation; pfam00668 210007004078 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 210007004079 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 210007004080 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 210007004081 acyl-activating enzyme (AAE) consensus motif; other site 210007004082 AMP binding site [chemical binding]; other site 210007004083 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 210007004084 Condensation domain; Region: Condensation; pfam00668 210007004085 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 210007004086 Condensation domain; Region: Condensation; pfam00668 210007004087 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 210007004088 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 210007004089 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 210007004090 active site 210007004091 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 210007004092 Condensation domain; Region: Condensation; pfam00668 210007004093 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 210007004094 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 210007004095 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 210007004096 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 210007004097 The adenylation domain of nonribosomal peptide synthetases (NRPS) similar to mycosubtilin synthase subunit A (MycA); Region: A_NRPS_MycA_like; cd05908 210007004098 acyl-activating enzyme (AAE) consensus motif; other site 210007004099 putative AMP binding site [chemical binding]; other site 210007004100 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 210007004101 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 210007004102 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 210007004103 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 210007004104 FtsX-like permease family; Region: FtsX; pfam02687 210007004105 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 210007004106 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 210007004107 FtsX-like permease family; Region: FtsX; pfam02687 210007004108 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 210007004109 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 210007004110 Walker A/P-loop; other site 210007004111 ATP binding site [chemical binding]; other site 210007004112 Q-loop/lid; other site 210007004113 ABC transporter signature motif; other site 210007004114 Walker B; other site 210007004115 D-loop; other site 210007004116 H-loop/switch region; other site 210007004117 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 210007004118 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 210007004119 HTH-like domain; Region: HTH_21; pfam13276 210007004120 Integrase core domain; Region: rve; pfam00665 210007004121 Integrase core domain; Region: rve_3; cl15866 210007004122 Integrase core domain; Region: rve; pfam00665 210007004123 HTH-like domain; Region: HTH_21; pfam13276 210007004124 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 210007004125 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 210007004126 Transposase IS200 like; Region: Y1_Tnp; pfam01797 210007004127 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 210007004128 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 210007004129 FtsX-like permease family; Region: FtsX; pfam02687 210007004130 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 210007004131 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 210007004132 FtsX-like permease family; Region: FtsX; pfam02687 210007004133 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 210007004134 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 210007004135 Walker A/P-loop; other site 210007004136 ATP binding site [chemical binding]; other site 210007004137 Q-loop/lid; other site 210007004138 ABC transporter signature motif; other site 210007004139 Walker B; other site 210007004140 D-loop; other site 210007004141 H-loop/switch region; other site 210007004142 Methyltransferase domain; Region: Methyltransf_31; pfam13847 210007004143 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 210007004144 S-adenosylmethionine binding site [chemical binding]; other site 210007004145 Integrase core domain; Region: rve; pfam00665 210007004146 Integrase core domain; Region: rve_2; pfam13333 210007004147 Helix-turn-helix domain; Region: HTH_28; pfam13518 210007004148 Helix-turn-helix domain; Region: HTH_28; pfam13518 210007004149 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 210007004150 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 210007004151 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 210007004152 active site 210007004153 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 210007004154 Homeodomain-like domain; Region: HTH_23; cl17451 210007004155 Transposase; Region: HTH_Tnp_1; cl17663 210007004156 Best Blastp Hit: gb|AAF73806.1|AF154034_3 (AF154034) IS3-Spn1 transposase [Streptococcus pneumoniae] 210007004157 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 210007004158 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 210007004159 substrate binding site [chemical binding]; other site 210007004160 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 210007004161 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 210007004162 substrate binding site [chemical binding]; other site 210007004163 ligand binding site [chemical binding]; other site 210007004164 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 210007004165 tartrate dehydrogenase; Region: TTC; TIGR02089 210007004166 2-isopropylmalate synthase; Validated; Region: PRK00915 210007004167 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 210007004168 active site 210007004169 catalytic residues [active] 210007004170 metal binding site [ion binding]; metal-binding site 210007004171 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 210007004172 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 210007004173 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 210007004174 Sugar specificity; other site 210007004175 Pyrimidine base specificity; other site 210007004176 ATP-binding site [chemical binding]; other site 210007004177 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 210007004178 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 210007004179 LabA_like proteins; Region: LabA_like; cd06167 210007004180 putative metal binding site [ion binding]; other site 210007004181 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 210007004182 DEAD-like helicases superfamily; Region: DEXDc; smart00487 210007004183 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 210007004184 ATP binding site [chemical binding]; other site 210007004185 putative Mg++ binding site [ion binding]; other site 210007004186 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 210007004187 nucleotide binding region [chemical binding]; other site 210007004188 ATP-binding site [chemical binding]; other site 210007004189 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 210007004190 active site 210007004191 metal-binding site [ion binding] 210007004192 active site 210007004193 nucleotide-binding site [chemical binding]; other site 210007004194 nucleotide-binding site [chemical binding]; other site 210007004195 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 210007004196 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 210007004197 Coenzyme A binding pocket [chemical binding]; other site 210007004198 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 210007004199 GTP-binding protein LepA; Provisional; Region: PRK05433 210007004200 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 210007004201 G1 box; other site 210007004202 putative GEF interaction site [polypeptide binding]; other site 210007004203 GTP/Mg2+ binding site [chemical binding]; other site 210007004204 Switch I region; other site 210007004205 G2 box; other site 210007004206 G3 box; other site 210007004207 Switch II region; other site 210007004208 G4 box; other site 210007004209 G5 box; other site 210007004210 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 210007004211 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 210007004212 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 210007004213 Glucan-binding protein C; Region: GbpC; pfam08363 210007004214 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 210007004215 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 210007004216 non-specific DNA binding site [nucleotide binding]; other site 210007004217 salt bridge; other site 210007004218 sequence-specific DNA binding site [nucleotide binding]; other site 210007004219 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 210007004220 non-specific DNA binding site [nucleotide binding]; other site 210007004221 salt bridge; other site 210007004222 sequence-specific DNA binding site [nucleotide binding]; other site 210007004223 Predicted transcriptional regulator [Transcription]; Region: COG2932 210007004224 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 210007004225 Catalytic site [active] 210007004226 Periplasmic copper-binding protein (NosD); Region: NosD; pfam05048 210007004227 Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681 210007004228 CRISPR-associated protein (Cas_Csn2); Region: Cas_Csn2; pfam09711 210007004229 tetramer interface [polypeptide binding]; other site 210007004230 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638 210007004231 CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720 210007004232 Predicted CRISPR-associated nuclease, contains McrA/HNH-nuclease and RuvC-like nuclease domain [Defense mechanisms]; Region: COG3513 210007004233 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 210007004234 CRISPR/Cas system-associated protein Cas9; Region: Csn1; cd09643 210007004235 Predicted flavoprotein [General function prediction only]; Region: COG0431 210007004236 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 210007004237 putative transposase OrfB; Reviewed; Region: PHA02517 210007004238 HTH-like domain; Region: HTH_21; pfam13276 210007004239 Integrase core domain; Region: rve; pfam00665 210007004240 Integrase core domain; Region: rve_2; pfam13333 210007004241 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 210007004242 Homeodomain-like domain; Region: HTH_23; cl17451 210007004243 Transposase; Region: HTH_Tnp_1; cl17663 210007004244 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 210007004245 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 210007004246 Predicted oxidoreductase [General function prediction only]; Region: COG3573 210007004247 Major Facilitator Superfamily; Region: MFS_1; pfam07690 210007004248 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 210007004249 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 210007004250 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 210007004251 Walker A/P-loop; other site 210007004252 ATP binding site [chemical binding]; other site 210007004253 Q-loop/lid; other site 210007004254 ABC transporter signature motif; other site 210007004255 Walker B; other site 210007004256 D-loop; other site 210007004257 H-loop/switch region; other site 210007004258 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 210007004259 FtsX-like permease family; Region: FtsX; pfam02687 210007004260 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 210007004261 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 210007004262 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 210007004263 active site 210007004264 motif I; other site 210007004265 motif II; other site 210007004266 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 210007004267 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 210007004268 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 210007004269 nudix motif; other site 210007004270 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 210007004271 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 210007004272 active site 210007004273 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 210007004274 active site 2 [active] 210007004275 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 210007004276 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 210007004277 FeS/SAM binding site; other site 210007004278 HemN C-terminal domain; Region: HemN_C; pfam06969 210007004279 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 210007004280 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 210007004281 WHG domain; Region: WHG; pfam13305 210007004282 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 210007004283 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 210007004284 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 210007004285 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 210007004286 E3 interaction surface; other site 210007004287 lipoyl attachment site [posttranslational modification]; other site 210007004288 e3 binding domain; Region: E3_binding; pfam02817 210007004289 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 210007004290 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 210007004291 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 210007004292 alpha subunit interface [polypeptide binding]; other site 210007004293 TPP binding site [chemical binding]; other site 210007004294 heterodimer interface [polypeptide binding]; other site 210007004295 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 210007004296 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 210007004297 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 210007004298 tetramer interface [polypeptide binding]; other site 210007004299 TPP-binding site [chemical binding]; other site 210007004300 heterodimer interface [polypeptide binding]; other site 210007004301 phosphorylation loop region [posttranslational modification] 210007004302 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 210007004303 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 210007004304 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 210007004305 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 210007004306 Clp amino terminal domain; Region: Clp_N; pfam02861 210007004307 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 210007004308 Walker A motif; other site 210007004309 ATP binding site [chemical binding]; other site 210007004310 Walker B motif; other site 210007004311 arginine finger; other site 210007004312 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 210007004313 Walker A motif; other site 210007004314 ATP binding site [chemical binding]; other site 210007004315 Walker B motif; other site 210007004316 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 210007004317 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 210007004318 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 210007004319 active site 210007004320 substrate binding site [chemical binding]; other site 210007004321 metal binding site [ion binding]; metal-binding site 210007004322 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 210007004323 YbbR-like protein; Region: YbbR; pfam07949 210007004324 YbbR-like protein; Region: YbbR; pfam07949 210007004325 Uncharacterized conserved protein [Function unknown]; Region: COG1624 210007004326 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 210007004327 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 210007004328 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 210007004329 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 210007004330 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 210007004331 catalytic triad [active] 210007004332 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 210007004333 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 210007004334 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 210007004335 ABC transporter; Region: ABC_tran_2; pfam12848 210007004336 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 210007004337 ABC transporter; Region: ABC_tran_2; pfam12848 210007004338 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 210007004339 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 210007004340 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 210007004341 DXD motif; other site 210007004342 Protein gp23 (Bacteriophage A118); Region: Phage_Gp23; pfam10669 210007004343 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 210007004344 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 210007004345 active site 210007004346 homodimer interface [polypeptide binding]; other site 210007004347 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 210007004348 active site 210007004349 Protein of unknown function (DUF1307); Region: DUF1307; pfam06998 210007004350 S-formylglutathione hydrolase; Region: PLN02442 210007004351 Predicted esterase [General function prediction only]; Region: COG0627 210007004352 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 210007004353 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 210007004354 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 210007004355 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 210007004356 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 210007004357 Walker A/P-loop; other site 210007004358 ATP binding site [chemical binding]; other site 210007004359 Q-loop/lid; other site 210007004360 ABC transporter signature motif; other site 210007004361 Walker B; other site 210007004362 D-loop; other site 210007004363 H-loop/switch region; other site 210007004364 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 210007004365 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 210007004366 TM-ABC transporter signature motif; other site 210007004367 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 210007004368 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 210007004369 zinc binding site [ion binding]; other site 210007004370 putative ligand binding site [chemical binding]; other site 210007004371 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 210007004372 Domain of unknown function (DUF814); Region: DUF814; pfam05670 210007004373 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 210007004374 Spore germination protein; Region: Spore_permease; cl17796 210007004375 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 210007004376 acetolactate synthase; Reviewed; Region: PRK08617 210007004377 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 210007004378 PYR/PP interface [polypeptide binding]; other site 210007004379 dimer interface [polypeptide binding]; other site 210007004380 TPP binding site [chemical binding]; other site 210007004381 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 210007004382 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 210007004383 TPP-binding site [chemical binding]; other site 210007004384 Tetratricopeptide repeat; Region: TPR_12; pfam13424 210007004385 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 210007004386 binding surface 210007004387 TPR motif; other site 210007004388 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 210007004389 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 210007004390 binding surface 210007004391 TPR motif; other site 210007004392 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 210007004393 Domain of unknown function DUF20; Region: UPF0118; pfam01594 210007004394 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 210007004395 putative active site [active] 210007004396 nucleotide binding site [chemical binding]; other site 210007004397 nudix motif; other site 210007004398 putative metal binding site [ion binding]; other site 210007004399 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 210007004400 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 210007004401 NAD binding site [chemical binding]; other site 210007004402 substrate binding site [chemical binding]; other site 210007004403 homodimer interface [polypeptide binding]; other site 210007004404 active site 210007004405 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 210007004406 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 210007004407 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 210007004408 substrate binding site; other site 210007004409 tetramer interface; other site 210007004410 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 210007004411 Uncharacterized conserved protein [Function unknown]; Region: COG0327 210007004412 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 210007004413 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 210007004414 Family of unknown function (DUF633); Region: DUF633; pfam04816 210007004415 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 210007004416 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 210007004417 Homoserine O-succinyltransferase; Region: HTS; pfam04204 210007004418 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 210007004419 proposed active site lysine [active] 210007004420 conserved cys residue [active] 210007004421 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 210007004422 active site 210007004423 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 210007004424 Predicted transcriptional regulator [Transcription]; Region: COG2378 210007004425 HTH domain; Region: HTH_11; pfam08279 210007004426 WYL domain; Region: WYL; pfam13280 210007004427 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 210007004428 DHH family; Region: DHH; pfam01368 210007004429 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 210007004430 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 210007004431 classical (c) SDRs; Region: SDR_c; cd05233 210007004432 NAD(P) binding site [chemical binding]; other site 210007004433 active site 210007004434 ribonuclease Z; Region: RNase_Z; TIGR02651 210007004435 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 210007004436 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 210007004437 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 210007004438 HflX GTPase family; Region: HflX; cd01878 210007004439 G1 box; other site 210007004440 GTP/Mg2+ binding site [chemical binding]; other site 210007004441 Switch I region; other site 210007004442 G2 box; other site 210007004443 G3 box; other site 210007004444 Switch II region; other site 210007004445 G4 box; other site 210007004446 G5 box; other site 210007004447 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 210007004448 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 210007004449 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 210007004450 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 210007004451 Predicted acetyltransferase [General function prediction only]; Region: COG3981 210007004452 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 210007004453 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 210007004454 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 210007004455 Walker A motif; other site 210007004456 ATP binding site [chemical binding]; other site 210007004457 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 210007004458 hypothetical protein; Provisional; Region: PRK07329 210007004459 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 210007004460 active site 210007004461 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 210007004462 substrate binding site [chemical binding]; other site 210007004463 THF binding site; other site 210007004464 zinc-binding site [ion binding]; other site 210007004465 Protein of unknown function (DUF3884); Region: DUF3884; pfam13024 210007004466 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 210007004467 active site 210007004468 catalytic residues [active] 210007004469 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 210007004470 beta-galactosidase; Region: BGL; TIGR03356 210007004471 phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394 210007004472 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 210007004473 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 210007004474 active site 210007004475 P-loop; other site 210007004476 phosphorylation site [posttranslational modification] 210007004477 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 210007004478 active site 210007004479 methionine cluster; other site 210007004480 phosphorylation site [posttranslational modification] 210007004481 metal binding site [ion binding]; metal-binding site 210007004482 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 210007004483 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 210007004484 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 210007004485 putative substrate binding site [chemical binding]; other site 210007004486 putative ATP binding site [chemical binding]; other site 210007004487 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 210007004488 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 210007004489 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 210007004490 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 210007004491 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 210007004492 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 210007004493 Family description; Region: UvrD_C_2; pfam13538 210007004494 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 210007004495 ATP-dependent nuclease subunit B; Region: rexB_recomb; TIGR02774 210007004496 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 210007004497 Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083 210007004498 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 210007004499 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 210007004500 putative efflux protein, MATE family; Region: matE; TIGR00797 210007004501 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 210007004502 putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055 210007004503 FeS/SAM binding site; other site 210007004504 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 210007004505 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 210007004506 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 210007004507 non-specific DNA binding site [nucleotide binding]; other site 210007004508 salt bridge; other site 210007004509 sequence-specific DNA binding site [nucleotide binding]; other site 210007004510 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 210007004511 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 210007004512 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 210007004513 putative tRNA-binding site [nucleotide binding]; other site 210007004514 B3/4 domain; Region: B3_4; pfam03483 210007004515 tRNA synthetase B5 domain; Region: B5; smart00874 210007004516 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 210007004517 dimer interface [polypeptide binding]; other site 210007004518 motif 1; other site 210007004519 motif 3; other site 210007004520 motif 2; other site 210007004521 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 210007004522 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 210007004523 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 210007004524 Coenzyme A binding pocket [chemical binding]; other site 210007004525 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 210007004526 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 210007004527 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 210007004528 dimer interface [polypeptide binding]; other site 210007004529 motif 1; other site 210007004530 active site 210007004531 motif 2; other site 210007004532 motif 3; other site 210007004533 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 210007004534 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 210007004535 Walker A/P-loop; other site 210007004536 ATP binding site [chemical binding]; other site 210007004537 Q-loop/lid; other site 210007004538 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 210007004539 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 210007004540 ABC transporter signature motif; other site 210007004541 Walker B; other site 210007004542 D-loop; other site 210007004543 H-loop/switch region; other site 210007004544 ribonuclease III; Reviewed; Region: rnc; PRK00102 210007004545 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 210007004546 dimerization interface [polypeptide binding]; other site 210007004547 active site 210007004548 metal binding site [ion binding]; metal-binding site 210007004549 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 210007004550 dsRNA binding site [nucleotide binding]; other site 210007004551 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 210007004552 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 210007004553 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 210007004554 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 210007004555 putative active site [active] 210007004556 heme pocket [chemical binding]; other site 210007004557 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 210007004558 dimer interface [polypeptide binding]; other site 210007004559 phosphorylation site [posttranslational modification] 210007004560 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 210007004561 ATP binding site [chemical binding]; other site 210007004562 Mg2+ binding site [ion binding]; other site 210007004563 G-X-G motif; other site 210007004564 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 210007004565 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 210007004566 active site 210007004567 phosphorylation site [posttranslational modification] 210007004568 intermolecular recognition site; other site 210007004569 dimerization interface [polypeptide binding]; other site 210007004570 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 210007004571 DNA binding site [nucleotide binding] 210007004572 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 210007004573 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 210007004574 Walker A/P-loop; other site 210007004575 ATP binding site [chemical binding]; other site 210007004576 Q-loop/lid; other site 210007004577 ABC transporter signature motif; other site 210007004578 Walker B; other site 210007004579 D-loop; other site 210007004580 H-loop/switch region; other site 210007004581 bifunctional adhesin/ABC transporter aspartate/glutamate-binding protein; Reviewed; Region: PRK11917 210007004582 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 210007004583 substrate binding pocket [chemical binding]; other site 210007004584 membrane-bound complex binding site; other site 210007004585 hinge residues; other site 210007004586 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 210007004587 dimer interface [polypeptide binding]; other site 210007004588 conserved gate region; other site 210007004589 putative PBP binding loops; other site 210007004590 ABC-ATPase subunit interface; other site 210007004591 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 210007004592 dimer interface [polypeptide binding]; other site 210007004593 conserved gate region; other site 210007004594 putative PBP binding loops; other site 210007004595 ABC-ATPase subunit interface; other site 210007004596 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 210007004597 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 210007004598 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 210007004599 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 210007004600 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 210007004601 hinge; other site 210007004602 active site 210007004603 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 210007004604 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 210007004605 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 210007004606 gamma subunit interface [polypeptide binding]; other site 210007004607 epsilon subunit interface [polypeptide binding]; other site 210007004608 LBP interface [polypeptide binding]; other site 210007004609 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 210007004610 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 210007004611 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 210007004612 alpha subunit interaction interface [polypeptide binding]; other site 210007004613 Walker A motif; other site 210007004614 ATP binding site [chemical binding]; other site 210007004615 Walker B motif; other site 210007004616 inhibitor binding site; inhibition site 210007004617 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 210007004618 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 210007004619 core domain interface [polypeptide binding]; other site 210007004620 delta subunit interface [polypeptide binding]; other site 210007004621 epsilon subunit interface [polypeptide binding]; other site 210007004622 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 210007004623 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 210007004624 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 210007004625 beta subunit interaction interface [polypeptide binding]; other site 210007004626 Walker A motif; other site 210007004627 ATP binding site [chemical binding]; other site 210007004628 Walker B motif; other site 210007004629 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 210007004630 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 210007004631 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 210007004632 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 210007004633 ATP synthase, F0 subunit b; Region: ATP_synt_b; TIGR01144 210007004634 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 210007004635 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 210007004636 F0F1 ATP synthase subunit C; Provisional; Region: PRK13467 210007004637 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 210007004638 homodimer interface [polypeptide binding]; other site 210007004639 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 210007004640 active site pocket [active] 210007004641 glycogen synthase; Provisional; Region: glgA; PRK00654 210007004642 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 210007004643 ADP-binding pocket [chemical binding]; other site 210007004644 homodimer interface [polypeptide binding]; other site 210007004645 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 210007004646 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 210007004647 active site 210007004648 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 210007004649 dimer interface [polypeptide binding]; other site 210007004650 N-terminal domain interface [polypeptide binding]; other site 210007004651 sulfate 1 binding site; other site 210007004652 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 210007004653 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 210007004654 ligand binding site; other site 210007004655 oligomer interface; other site 210007004656 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 210007004657 dimer interface [polypeptide binding]; other site 210007004658 N-terminal domain interface [polypeptide binding]; other site 210007004659 sulfate 1 binding site; other site 210007004660 glycogen branching enzyme; Provisional; Region: PRK12313 210007004661 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 210007004662 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 210007004663 active site 210007004664 catalytic site [active] 210007004665 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 210007004666 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cl04227 210007004667 carbohydrate binding site [chemical binding]; other site 210007004668 pullulanase, type I; Region: pulA_typeI; TIGR02104 210007004669 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 210007004670 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 210007004671 Ca binding site [ion binding]; other site 210007004672 active site 210007004673 catalytic site [active] 210007004674 putative lipid kinase; Reviewed; Region: PRK13055 210007004675 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 210007004676 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 210007004677 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 210007004678 nucleotide binding pocket [chemical binding]; other site 210007004679 K-X-D-G motif; other site 210007004680 catalytic site [active] 210007004681 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 210007004682 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 210007004683 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 210007004684 Dimer interface [polypeptide binding]; other site 210007004685 BRCT sequence motif; other site 210007004686 Predicted membrane protein [Function unknown]; Region: COG4708 210007004687 Predicted membrane protein [Function unknown]; Region: COG2246 210007004688 GtrA-like protein; Region: GtrA; pfam04138 210007004689 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 210007004690 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 210007004691 active site 210007004692 phosphorylation site [posttranslational modification] 210007004693 intermolecular recognition site; other site 210007004694 dimerization interface [polypeptide binding]; other site 210007004695 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 210007004696 DNA binding residues [nucleotide binding] 210007004697 dimerization interface [polypeptide binding]; other site 210007004698 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 210007004699 Histidine kinase; Region: HisKA_3; pfam07730 210007004700 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 210007004701 ATP binding site [chemical binding]; other site 210007004702 Mg2+ binding site [ion binding]; other site 210007004703 G-X-G motif; other site 210007004704 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 210007004705 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 210007004706 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 210007004707 Walker A/P-loop; other site 210007004708 ATP binding site [chemical binding]; other site 210007004709 Q-loop/lid; other site 210007004710 ABC transporter signature motif; other site 210007004711 Walker B; other site 210007004712 D-loop; other site 210007004713 H-loop/switch region; other site 210007004714 EXLDI protein; Region: EXLDI; TIGR04342 210007004715 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 210007004716 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 210007004717 active site 210007004718 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 210007004719 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 210007004720 DNA-binding site [nucleotide binding]; DNA binding site 210007004721 DRTGG domain; Region: DRTGG; pfam07085 210007004722 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 210007004723 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 210007004724 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 210007004725 Predicted membrane protein [Function unknown]; Region: COG2510 210007004726 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 210007004727 TrkA-N domain; Region: TrkA_N; pfam02254 210007004728 TrkA-C domain; Region: TrkA_C; pfam02080 210007004729 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 210007004730 TrkA-N domain; Region: TrkA_N; pfam02254 210007004731 TrkA-C domain; Region: TrkA_C; pfam02080 210007004732 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 210007004733 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 210007004734 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 210007004735 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 210007004736 Soluble P-type ATPase [General function prediction only]; Region: COG4087 210007004737 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 210007004738 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 210007004739 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 210007004740 4-alpha-glucanotransferase; Provisional; Region: PRK14508 210007004741 Transcriptional regulators [Transcription]; Region: PurR; COG1609 210007004742 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 210007004743 DNA binding site [nucleotide binding] 210007004744 domain linker motif; other site 210007004745 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 210007004746 putative dimerization interface [polypeptide binding]; other site 210007004747 putative ligand binding site [chemical binding]; other site 210007004748 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 210007004749 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 210007004750 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 210007004751 dimer interface [polypeptide binding]; other site 210007004752 conserved gate region; other site 210007004753 ABC-ATPase subunit interface; other site 210007004754 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 210007004755 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 210007004756 dimer interface [polypeptide binding]; other site 210007004757 conserved gate region; other site 210007004758 putative PBP binding loops; other site 210007004759 ABC-ATPase subunit interface; other site 210007004760 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 210007004761 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 210007004762 Walker A/P-loop; other site 210007004763 ATP binding site [chemical binding]; other site 210007004764 Q-loop/lid; other site 210007004765 ABC transporter signature motif; other site 210007004766 Walker B; other site 210007004767 D-loop; other site 210007004768 H-loop/switch region; other site 210007004769 TOBE domain; Region: TOBE_2; pfam08402 210007004770 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 210007004771 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 210007004772 hinge; other site 210007004773 active site 210007004774 S-adenosylmethionine synthetase; Validated; Region: PRK05250 210007004775 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 210007004776 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 210007004777 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 210007004778 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 210007004779 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432 210007004780 DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481 210007004781 active site 210007004782 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 210007004783 ABC transporter signature motif; other site 210007004784 Walker B; other site 210007004785 D-loop; other site 210007004786 H-loop/switch region; other site 210007004787 Biotin operon repressor [Transcription]; Region: BirA; COG1654 210007004788 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 210007004789 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 210007004790 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 210007004791 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 210007004792 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 210007004793 Walker A motif; other site 210007004794 ATP binding site [chemical binding]; other site 210007004795 Walker B motif; other site 210007004796 arginine finger; other site 210007004797 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 210007004798 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 210007004799 myosin-cross-reactive antigen; Provisional; Region: PRK13977 210007004800 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 210007004801 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 210007004802 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 210007004803 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 210007004804 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 210007004805 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 210007004806 active site 210007004807 dimer interface [polypeptide binding]; other site 210007004808 motif 1; other site 210007004809 motif 2; other site 210007004810 motif 3; other site 210007004811 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 210007004812 anticodon binding site; other site 210007004813 AAA domain; Region: AAA_17; pfam13207 210007004814 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 210007004815 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 210007004816 putative ADP-binding pocket [chemical binding]; other site 210007004817 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 210007004818 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 210007004819 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 210007004820 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 210007004821 active site 210007004822 Na/Ca binding site [ion binding]; other site 210007004823 catalytic site [active] 210007004824 catabolite control protein A; Region: ccpA; TIGR01481 210007004825 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 210007004826 DNA binding site [nucleotide binding] 210007004827 domain linker motif; other site 210007004828 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 210007004829 dimerization interface [polypeptide binding]; other site 210007004830 effector binding site; other site 210007004831 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 210007004832 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 210007004833 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 210007004834 active site 210007004835 Putative integral membrane protein DUF46; Region: DUF46; cl17511 210007004836 Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338 210007004837 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 210007004838 active site 210007004839 zinc binding site [ion binding]; other site 210007004840 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 210007004841 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 210007004842 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 210007004843 methionine cluster; other site 210007004844 active site 210007004845 phosphorylation site [posttranslational modification] 210007004846 metal binding site [ion binding]; metal-binding site 210007004847 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 210007004848 HTH domain; Region: HTH_11; pfam08279 210007004849 Mga helix-turn-helix domain; Region: Mga; pfam05043 210007004850 PRD domain; Region: PRD; pfam00874 210007004851 PRD domain; Region: PRD; pfam00874 210007004852 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 210007004853 active site 210007004854 P-loop; other site 210007004855 phosphorylation site [posttranslational modification] 210007004856 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 210007004857 active site 210007004858 phosphorylation site [posttranslational modification] 210007004859 cellobiose phosphotransferase system IIB component; Reviewed; Region: celB; PRK09590 210007004860 active site 210007004861 P-loop; other site 210007004862 phosphorylation site [posttranslational modification] 210007004863 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 210007004864 beta-galactosidase; Region: BGL; TIGR03356 210007004865 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 210007004866 dimer interface [polypeptide binding]; other site 210007004867 FMN binding site [chemical binding]; other site 210007004868 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 210007004869 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 210007004870 dimer interface [polypeptide binding]; other site 210007004871 active site 210007004872 metal binding site [ion binding]; metal-binding site 210007004873 glutathione binding site [chemical binding]; other site 210007004874 Predicted transcriptional regulators [Transcription]; Region: COG1695 210007004875 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 210007004876 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 210007004877 Major Facilitator Superfamily; Region: MFS_1; pfam07690 210007004878 putative substrate translocation pore; other site 210007004879 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 210007004880 SmpB-tmRNA interface; other site 210007004881 ribonuclease R; Region: RNase_R; TIGR02063 210007004882 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 210007004883 RNB domain; Region: RNB; pfam00773 210007004884 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 210007004885 RNA binding site [nucleotide binding]; other site 210007004886 preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870 210007004887 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 210007004888 drug efflux system protein MdtG; Provisional; Region: PRK09874 210007004889 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 210007004890 putative substrate translocation pore; other site 210007004891 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 210007004892 S-adenosylmethionine binding site [chemical binding]; other site 210007004893 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 210007004894 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 210007004895 CoA-binding site [chemical binding]; other site 210007004896 ATP-binding [chemical binding]; other site 210007004897 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 210007004898 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 210007004899 DNA binding site [nucleotide binding] 210007004900 catalytic residue [active] 210007004901 H2TH interface [polypeptide binding]; other site 210007004902 putative catalytic residues [active] 210007004903 turnover-facilitating residue; other site 210007004904 intercalation triad [nucleotide binding]; other site 210007004905 8OG recognition residue [nucleotide binding]; other site 210007004906 putative reading head residues; other site 210007004907 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 210007004908 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 210007004909 DinB superfamily; Region: DinB_2; pfam12867 210007004910 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 210007004911 nudix motif; other site 210007004912 GTPase Era; Reviewed; Region: era; PRK00089 210007004913 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 210007004914 G1 box; other site 210007004915 GTP/Mg2+ binding site [chemical binding]; other site 210007004916 Switch I region; other site 210007004917 G2 box; other site 210007004918 Switch II region; other site 210007004919 G3 box; other site 210007004920 G4 box; other site 210007004921 G5 box; other site 210007004922 KH domain; Region: KH_2; pfam07650 210007004923 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 210007004924 metal-binding heat shock protein; Provisional; Region: PRK00016 210007004925 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 210007004926 PhoH-like protein; Region: PhoH; pfam02562 210007004927 hypothetical protein; Provisional; Region: PRK13672 210007004928 methionine sulfoxide reductase A; Provisional; Region: PRK14054 210007004929 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 210007004930 S1 domain; Region: S1_2; pfam13509 210007004931 ribosome recycling factor; Reviewed; Region: frr; PRK00083 210007004932 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 210007004933 hinge region; other site 210007004934 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 210007004935 putative nucleotide binding site [chemical binding]; other site 210007004936 uridine monophosphate binding site [chemical binding]; other site 210007004937 homohexameric interface [polypeptide binding]; other site 210007004938 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 210007004939 mRNA/rRNA interface [nucleotide binding]; other site 210007004940 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 210007004941 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 210007004942 23S rRNA interface [nucleotide binding]; other site 210007004943 L7/L12 interface [polypeptide binding]; other site 210007004944 putative thiostrepton binding site; other site 210007004945 L25 interface [polypeptide binding]; other site 210007004946 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 210007004947 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 210007004948 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 210007004949 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 210007004950 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 210007004951 active site 210007004952 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 210007004953 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 210007004954 dimer interface [polypeptide binding]; other site 210007004955 ADP-ribose binding site [chemical binding]; other site 210007004956 active site 210007004957 nudix motif; other site 210007004958 metal binding site [ion binding]; metal-binding site 210007004959 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 210007004960 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 210007004961 Substrate binding site; other site 210007004962 Mg++ binding site; other site 210007004963 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 210007004964 active site 210007004965 substrate binding site [chemical binding]; other site 210007004966 CoA binding site [chemical binding]; other site 210007004967 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 210007004968 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 210007004969 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 210007004970 active site 210007004971 HIGH motif; other site 210007004972 KMSKS motif; other site 210007004973 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 210007004974 tRNA binding surface [nucleotide binding]; other site 210007004975 anticodon binding site; other site 210007004976 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 210007004977 dimer interface [polypeptide binding]; other site 210007004978 putative tRNA-binding site [nucleotide binding]; other site 210007004979 Predicted membrane protein [Function unknown]; Region: COG2323 210007004980 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 210007004981 tellurite resistance protein TehB; Provisional; Region: PRK12335 210007004982 Domain of unknown function (DUF1971); Region: DUF1971; pfam09313 210007004983 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 210007004984 S-adenosylmethionine binding site [chemical binding]; other site 210007004985 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 210007004986 SdpI/YhfL protein family; Region: SdpI; pfam13630 210007004987 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 210007004988 dimerization interface [polypeptide binding]; other site 210007004989 putative DNA binding site [nucleotide binding]; other site 210007004990 putative Zn2+ binding site [ion binding]; other site 210007004991 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 210007004992 active site 210007004993 putative catalytic site [active] 210007004994 DNA binding site [nucleotide binding] 210007004995 putative phosphate binding site [ion binding]; other site 210007004996 metal binding site A [ion binding]; metal-binding site 210007004997 AP binding site [nucleotide binding]; other site 210007004998 metal binding site B [ion binding]; metal-binding site 210007004999 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 210007005000 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 210007005001 minor groove reading motif; other site 210007005002 helix-hairpin-helix signature motif; other site 210007005003 substrate binding pocket [chemical binding]; other site 210007005004 active site 210007005005 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 210007005006 ArsC family; Region: ArsC; pfam03960 210007005007 putative ArsC-like catalytic residues; other site 210007005008 putative TRX-like catalytic residues [active] 210007005009 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 210007005010 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 210007005011 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 210007005012 DNA binding site [nucleotide binding] 210007005013 active site 210007005014 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 210007005015 D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389 210007005016 putative ligand binding site [chemical binding]; other site 210007005017 putative NAD binding site [chemical binding]; other site 210007005018 putative catalytic site [active] 210007005019 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 210007005020 L-serine binding site [chemical binding]; other site 210007005021 ACT domain interface; other site 210007005022 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 210007005023 Coenzyme A binding pocket [chemical binding]; other site 210007005024 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 210007005025 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 210007005026 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 210007005027 catalytic residue [active] 210007005028 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 210007005029 Nitrogen regulatory protein P-II; Region: P-II; smart00938 210007005030 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 210007005031 Predicted methyltransferases [General function prediction only]; Region: COG0313 210007005032 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 210007005033 putative SAM binding site [chemical binding]; other site 210007005034 putative homodimer interface [polypeptide binding]; other site 210007005035 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 210007005036 Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774 210007005037 DNA polymerase III subunit delta'; Validated; Region: PRK07276 210007005038 DNA polymerase III subunit delta'; Validated; Region: PRK08485 210007005039 thymidylate kinase; Validated; Region: tmk; PRK00698 210007005040 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 210007005041 TMP-binding site; other site 210007005042 ATP-binding site [chemical binding]; other site 210007005043 FOG: CBS domain [General function prediction only]; Region: COG0517 210007005044 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 210007005045 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 210007005046 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 210007005047 Walker A/P-loop; other site 210007005048 ATP binding site [chemical binding]; other site 210007005049 Q-loop/lid; other site 210007005050 ABC transporter signature motif; other site 210007005051 Walker B; other site 210007005052 D-loop; other site 210007005053 H-loop/switch region; other site 210007005054 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 210007005055 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 210007005056 Walker A/P-loop; other site 210007005057 ATP binding site [chemical binding]; other site 210007005058 Q-loop/lid; other site 210007005059 ABC transporter signature motif; other site 210007005060 Walker B; other site 210007005061 D-loop; other site 210007005062 H-loop/switch region; other site 210007005063 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 210007005064 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 210007005065 TM-ABC transporter signature motif; other site 210007005066 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 210007005067 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 210007005068 TM-ABC transporter signature motif; other site 210007005069 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 210007005070 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 210007005071 putative ligand binding site [chemical binding]; other site 210007005072 hypothetical protein; Provisional; Region: PRK02302 210007005073 Protein of unknown function (DUF964); Region: DUF964; pfam06133 210007005074 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 210007005075 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 210007005076 oligomer interface [polypeptide binding]; other site 210007005077 active site residues [active] 210007005078 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 210007005079 active site 210007005080 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 210007005081 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 210007005082 pyridoxal 5'-phosphate binding site [chemical binding]; other site 210007005083 homodimer interface [polypeptide binding]; other site 210007005084 catalytic residue [active] 210007005085 cystathionine gamma-synthase; Reviewed; Region: PRK07269 210007005086 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 210007005087 homodimer interface [polypeptide binding]; other site 210007005088 substrate-cofactor binding pocket; other site 210007005089 pyridoxal 5'-phosphate binding site [chemical binding]; other site 210007005090 catalytic residue [active] 210007005091 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 210007005092 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 210007005093 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 210007005094 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 210007005095 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 210007005096 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 210007005097 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 210007005098 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 210007005099 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 210007005100 substrate binding site [chemical binding]; other site 210007005101 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 210007005102 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 210007005103 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 210007005104 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_3; cd03140 210007005105 conserved cys residue [active] 210007005106 Predicted transcriptional regulator [Transcription]; Region: COG2378 210007005107 HTH domain; Region: HTH_11; pfam08279 210007005108 WYL domain; Region: WYL; pfam13280 210007005109 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 210007005110 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 210007005111 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 210007005112 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 210007005113 DHHA2 domain; Region: DHHA2; pfam02833 210007005114 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 210007005115 DltD N-terminal region; Region: DltD_N; pfam04915 210007005116 DltD central region; Region: DltD_M; pfam04918 210007005117 DltD C-terminal region; Region: DltD_C; pfam04914 210007005118 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 210007005119 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 210007005120 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 210007005121 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 210007005122 acyl-activating enzyme (AAE) consensus motif; other site 210007005123 AMP binding site [chemical binding]; other site 210007005124 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 210007005125 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 210007005126 FeS/SAM binding site; other site 210007005127 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 210007005128 Domain of unknown function DUF21; Region: DUF21; pfam01595 210007005129 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 210007005130 Transporter associated domain; Region: CorC_HlyC; smart01091 210007005131 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 210007005132 Domain of unknown function DUF20; Region: UPF0118; pfam01594 210007005133 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 210007005134 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 210007005135 Walker A/P-loop; other site 210007005136 ATP binding site [chemical binding]; other site 210007005137 Q-loop/lid; other site 210007005138 ABC transporter signature motif; other site 210007005139 Walker B; other site 210007005140 D-loop; other site 210007005141 H-loop/switch region; other site 210007005142 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 210007005143 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 210007005144 LrgB-like family; Region: LrgB; pfam04172 210007005145 LrgA family; Region: LrgA; pfam03788 210007005146 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 210007005147 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 210007005148 active site 210007005149 Predicted membrane protein [Function unknown]; Region: COG3601 210007005150 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 210007005151 Predicted transcriptional regulators [Transcription]; Region: COG1695 210007005152 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 210007005153 Predicted membrane protein [Function unknown]; Region: COG4709 210007005154 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 210007005155 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 210007005156 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 210007005157 TrkA-N domain; Region: TrkA_N; pfam02254 210007005158 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 210007005159 TrkA-C domain; Region: TrkA_C; pfam02080 210007005160 TrkA-N domain; Region: TrkA_N; pfam02254 210007005161 TrkA-C domain; Region: TrkA_C; pfam02080 210007005162 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 210007005163 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 210007005164 hypothetical protein; Validated; Region: PRK00041 210007005165 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 210007005166 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 210007005167 RNA binding surface [nucleotide binding]; other site 210007005168 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 210007005169 active site 210007005170 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 210007005171 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 210007005172 site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436 210007005173 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 210007005174 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 210007005175 active site 210007005176 catalytic residues [active] 210007005177 DNA binding site [nucleotide binding] 210007005178 Int/Topo IB signature motif; other site 210007005179 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 210007005180 FOG: CBS domain [General function prediction only]; Region: COG0517 210007005181 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 210007005182 active site 210007005183 metal binding site [ion binding]; metal-binding site 210007005184 homotetramer interface [polypeptide binding]; other site 210007005185 putative deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein; Reviewed; Region: PRK02491 210007005186 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 210007005187 active site 210007005188 dimerization interface [polypeptide binding]; other site 210007005189 glutamate racemase; Provisional; Region: PRK00865 210007005190 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 210007005191 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 210007005192 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 210007005193 active site 210007005194 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 210007005195 substrate binding site [chemical binding]; other site 210007005196 catalytic residues [active] 210007005197 dimer interface [polypeptide binding]; other site 210007005198 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 210007005199 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 210007005200 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 210007005201 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 210007005202 Zn2+ binding site [ion binding]; other site 210007005203 Mg2+ binding site [ion binding]; other site 210007005204 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 210007005205 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 210007005206 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 210007005207 acylphosphatase; Provisional; Region: PRK14434 210007005208 OxaA-like protein precursor; Provisional; Region: PRK02463 210007005209 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 210007005210 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 210007005211 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 210007005212 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 210007005213 YceG-like family; Region: YceG; pfam02618 210007005214 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 210007005215 dimerization interface [polypeptide binding]; other site 210007005216 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 210007005217 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 210007005218 Coenzyme A binding pocket [chemical binding]; other site 210007005219 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 210007005220 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 210007005221 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 210007005222 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 210007005223 SWIM zinc finger; Region: SWIM; pfam04434 210007005224 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 210007005225 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 210007005226 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 210007005227 ATP binding site [chemical binding]; other site 210007005228 putative Mg++ binding site [ion binding]; other site 210007005229 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 210007005230 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 210007005231 nucleotide binding region [chemical binding]; other site 210007005232 ATP-binding site [chemical binding]; other site 210007005233 acetyl-CoA carboxylase subunit alpha; Provisional; Region: PRK12319 210007005234 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 210007005235 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 210007005236 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 210007005237 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 210007005238 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 210007005239 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 210007005240 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 210007005241 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 210007005242 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 210007005243 carboxyltransferase (CT) interaction site; other site 210007005244 biotinylation site [posttranslational modification]; other site 210007005245 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 210007005246 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 210007005247 dimer interface [polypeptide binding]; other site 210007005248 active site 210007005249 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 210007005250 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 210007005251 NAD(P) binding site [chemical binding]; other site 210007005252 homotetramer interface [polypeptide binding]; other site 210007005253 homodimer interface [polypeptide binding]; other site 210007005254 active site 210007005255 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 210007005256 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 210007005257 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 210007005258 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 210007005259 FMN binding site [chemical binding]; other site 210007005260 substrate binding site [chemical binding]; other site 210007005261 putative catalytic residue [active] 210007005262 acyl carrier protein; Provisional; Region: acpP; PRK00982 210007005263 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 210007005264 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 210007005265 dimer interface [polypeptide binding]; other site 210007005266 active site 210007005267 CoA binding pocket [chemical binding]; other site 210007005268 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 210007005269 MarR family; Region: MarR_2; pfam12802 210007005270 enoyl-CoA hydratase; Provisional; Region: PRK07260 210007005271 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 210007005272 substrate binding site [chemical binding]; other site 210007005273 oxyanion hole (OAH) forming residues; other site 210007005274 trimer interface [polypeptide binding]; other site 210007005275 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 210007005276 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 210007005277 motif II; other site 210007005278 aspartate kinase; Reviewed; Region: PRK09034 210007005279 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 210007005280 putative catalytic residues [active] 210007005281 putative nucleotide binding site [chemical binding]; other site 210007005282 putative aspartate binding site [chemical binding]; other site 210007005283 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 210007005284 allosteric regulatory residue; other site 210007005285 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 210007005286 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 210007005287 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 210007005288 potential frameshift: common BLAST hit: gi|337281888|ref|YP_004621359.1| CRISPR-associated protein cas1 210007005289 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 210007005290 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656 210007005291 CRISPR-associated protein Cas4 (RecB family exonuclease) [Defense mechanisms]; Region: COG1468 210007005292 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cd09689 210007005293 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004 210007005294 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004 210007005295 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09651 210007005296 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 210007005297 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 210007005298 CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203 210007005299 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 210007005300 WYL domain; Region: WYL; pfam13280 210007005301 PIN domain; Region: PIN_3; pfam13470 210007005302 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 210007005303 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 210007005304 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 210007005305 active site 210007005306 HIGH motif; other site 210007005307 nucleotide binding site [chemical binding]; other site 210007005308 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 210007005309 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 210007005310 active site 210007005311 KMSKS motif; other site 210007005312 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 210007005313 tRNA binding surface [nucleotide binding]; other site 210007005314 anticodon binding site; other site 210007005315 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 210007005316 Domain of unknown function (DUF1912); Region: DUF1912; pfam08930 210007005317 RelB antitoxin; Region: RelB; cl01171 210007005318 flavoprotein NrdI; Provisional; Region: PRK02551 210007005319 TRAM domain; Region: TRAM; cl01282 210007005320 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 210007005321 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 210007005322 recombination regulator RecX; Provisional; Region: recX; PRK14135 210007005323 hypothetical protein; Provisional; Region: PRK13662 210007005324 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 210007005325 prolyl-tRNA synthetase; Provisional; Region: PRK09194 210007005326 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 210007005327 dimer interface [polypeptide binding]; other site 210007005328 motif 1; other site 210007005329 active site 210007005330 motif 2; other site 210007005331 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 210007005332 putative deacylase active site [active] 210007005333 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 210007005334 active site 210007005335 motif 3; other site 210007005336 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 210007005337 anticodon binding site; other site 210007005338 RIP metalloprotease RseP; Region: TIGR00054 210007005339 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 210007005340 active site 210007005341 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 210007005342 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 210007005343 protein binding site [polypeptide binding]; other site 210007005344 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 210007005345 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 210007005346 putative substrate binding region [chemical binding]; other site 210007005347 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 210007005348 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 210007005349 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 210007005350 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 210007005351 catalytic residue [active] 210007005352 putative FPP diphosphate binding site; other site 210007005353 putative FPP binding hydrophobic cleft; other site 210007005354 dimer interface [polypeptide binding]; other site 210007005355 putative IPP diphosphate binding site; other site 210007005356 preprotein translocase subunit YajC; Validated; Region: yajC; PRK06531 210007005357 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 210007005358 catalytic residues [active] 210007005359 hypothetical protein; Provisional; Region: PRK12378 210007005360 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 210007005361 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 210007005362 DNA binding residues [nucleotide binding] 210007005363 dimer interface [polypeptide binding]; other site 210007005364 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 210007005365 hypothetical protein; Provisional; Region: PRK13670 210007005366 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 210007005367 3-ketoacyl-CoA synthase; Region: PLN02854 210007005368 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 210007005369 S-adenosylmethionine binding site [chemical binding]; other site 210007005370 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 210007005371 Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713 210007005372 Zn2+ binding site [ion binding]; other site 210007005373 Mg2+ binding site [ion binding]; other site 210007005374 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 210007005375 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 210007005376 active site 210007005377 (T/H)XGH motif; other site 210007005378 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 210007005379 GTPase YqeH; Provisional; Region: PRK13796 210007005380 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 210007005381 GTP/Mg2+ binding site [chemical binding]; other site 210007005382 G4 box; other site 210007005383 G5 box; other site 210007005384 G1 box; other site 210007005385 Switch I region; other site 210007005386 G2 box; other site 210007005387 G3 box; other site 210007005388 Switch II region; other site 210007005389 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 210007005390 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 210007005391 active site 210007005392 motif I; other site 210007005393 motif II; other site 210007005394 Protein of unknown function (DUF4230); Region: DUF4230; pfam14014 210007005395 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 210007005396 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 210007005397 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 210007005398 glycosyltransferase, MGT family; Region: MGT; TIGR01426 210007005399 active site 210007005400 TDP-binding site; other site 210007005401 acceptor substrate-binding pocket; other site 210007005402 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 210007005403 EamA-like transporter family; Region: EamA; pfam00892 210007005404 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 210007005405 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 210007005406 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 210007005407 Walker A/P-loop; other site 210007005408 ATP binding site [chemical binding]; other site 210007005409 Q-loop/lid; other site 210007005410 ABC transporter signature motif; other site 210007005411 Walker B; other site 210007005412 D-loop; other site 210007005413 H-loop/switch region; other site 210007005414 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 210007005415 Helix-turn-helix domain; Region: HTH_38; pfam13936 210007005416 Transposase; Region: DDE_Tnp_ISL3; pfam01610 210007005417 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 210007005418 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 210007005419 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 210007005420 dimer interface [polypeptide binding]; other site 210007005421 phosphorylation site [posttranslational modification] 210007005422 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 210007005423 ATP binding site [chemical binding]; other site 210007005424 Mg2+ binding site [ion binding]; other site 210007005425 G-X-G motif; other site 210007005426 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 210007005427 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 210007005428 active site 210007005429 phosphorylation site [posttranslational modification] 210007005430 intermolecular recognition site; other site 210007005431 dimerization interface [polypeptide binding]; other site 210007005432 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 210007005433 DNA binding site [nucleotide binding] 210007005434 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 210007005435 nucleic acid binding site [nucleotide binding]; other site 210007005436 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 210007005437 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 210007005438 GatB domain; Region: GatB_Yqey; pfam02637 210007005439 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 210007005440 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 210007005441 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 210007005442 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 210007005443 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 210007005444 dimer interface [polypeptide binding]; other site 210007005445 anticodon binding site; other site 210007005446 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 210007005447 homodimer interface [polypeptide binding]; other site 210007005448 motif 1; other site 210007005449 active site 210007005450 motif 2; other site 210007005451 GAD domain; Region: GAD; pfam02938 210007005452 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 210007005453 active site 210007005454 motif 3; other site 210007005455 Isochorismatase family; Region: Isochorismatase; pfam00857 210007005456 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 210007005457 catalytic triad [active] 210007005458 conserved cis-peptide bond; other site 210007005459 transcriptional repressor CodY; Validated; Region: PRK04158 210007005460 CodY GAF-like domain; Region: CodY; pfam06018 210007005461 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 210007005462 dimerization interface [polypeptide binding]; other site 210007005463 putative Zn2+ binding site [ion binding]; other site 210007005464 putative DNA binding site [nucleotide binding]; other site 210007005465 aminotransferase AlaT; Validated; Region: PRK09265 210007005466 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 210007005467 pyridoxal 5'-phosphate binding site [chemical binding]; other site 210007005468 homodimer interface [polypeptide binding]; other site 210007005469 catalytic residue [active] 210007005470 BioY family; Region: BioY; pfam02632 210007005471 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 210007005472 Ligand Binding Site [chemical binding]; other site 210007005473 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 210007005474 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 210007005475 active site 210007005476 motif I; other site 210007005477 motif II; other site 210007005478 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 210007005479 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4696 210007005480 metal binding site [ion binding]; metal-binding site 210007005481 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 210007005482 active site 210007005483 homotetramer interface [polypeptide binding]; other site 210007005484 homodimer interface [polypeptide binding]; other site 210007005485 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 210007005486 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 210007005487 generic binding surface II; other site 210007005488 ssDNA binding site; other site 210007005489 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 210007005490 ATP binding site [chemical binding]; other site 210007005491 putative Mg++ binding site [ion binding]; other site 210007005492 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 210007005493 nucleotide binding region [chemical binding]; other site 210007005494 ATP-binding site [chemical binding]; other site 210007005495 alanine racemase; Reviewed; Region: alr; PRK00053 210007005496 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 210007005497 active site 210007005498 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 210007005499 dimer interface [polypeptide binding]; other site 210007005500 substrate binding site [chemical binding]; other site 210007005501 catalytic residues [active] 210007005502 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 210007005503 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 210007005504 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 210007005505 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; cl17260 210007005506 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 210007005507 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 210007005508 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 210007005509 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 210007005510 nucleotide binding region [chemical binding]; other site 210007005511 ATP-binding site [chemical binding]; other site 210007005512 SEC-C motif; Region: SEC-C; pfam02810 210007005513 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 210007005514 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 210007005515 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 210007005516 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 210007005517 nucleotide binding site [chemical binding]; other site 210007005518 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 210007005519 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 210007005520 active site turn [active] 210007005521 phosphorylation site [posttranslational modification] 210007005522 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 210007005523 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 210007005524 HPr interaction site; other site 210007005525 glycerol kinase (GK) interaction site [polypeptide binding]; other site 210007005526 active site 210007005527 phosphorylation site [posttranslational modification] 210007005528 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 210007005529 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 210007005530 substrate binding [chemical binding]; other site 210007005531 active site 210007005532 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 210007005533 Transcriptional regulators [Transcription]; Region: PurR; COG1609 210007005534 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 210007005535 DNA binding site [nucleotide binding] 210007005536 domain linker motif; other site 210007005537 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 210007005538 dimerization interface [polypeptide binding]; other site 210007005539 ligand binding site [chemical binding]; other site 210007005540 sodium binding site [ion binding]; other site 210007005541 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 210007005542 putative RNA binding site [nucleotide binding]; other site 210007005543 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 210007005544 elongation factor P; Validated; Region: PRK00529 210007005545 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 210007005546 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 210007005547 RNA binding site [nucleotide binding]; other site 210007005548 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 210007005549 RNA binding site [nucleotide binding]; other site 210007005550 Ion transport protein; Region: Ion_trans; pfam00520 210007005551 Ion channel; Region: Ion_trans_2; pfam07885 210007005552 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 210007005553 catalytic motif [active] 210007005554 Zn binding site [ion binding]; other site 210007005555 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 210007005556 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 210007005557 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 210007005558 active site 210007005559 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 210007005560 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 210007005561 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 210007005562 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 210007005563 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 210007005564 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 210007005565 Cl binding site [ion binding]; other site 210007005566 oligomer interface [polypeptide binding]; other site 210007005567 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 210007005568 LytTr DNA-binding domain; Region: LytTR; pfam04397 210007005569 TraX protein; Region: TraX; cl05434 210007005570 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 210007005571 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 210007005572 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 210007005573 dimer interface [polypeptide binding]; other site 210007005574 ssDNA binding site [nucleotide binding]; other site 210007005575 tetramer (dimer of dimers) interface [polypeptide binding]; other site 210007005576 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 210007005577 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 210007005578 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 210007005579 minor groove reading motif; other site 210007005580 helix-hairpin-helix signature motif; other site 210007005581 substrate binding pocket [chemical binding]; other site 210007005582 active site 210007005583 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 210007005584 DNA binding and oxoG recognition site [nucleotide binding] 210007005585 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 210007005586 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 210007005587 catalytic Zn binding site [ion binding]; other site 210007005588 NAD(P) binding site [chemical binding]; other site 210007005589 structural Zn binding site [ion binding]; other site 210007005590 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 210007005591 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 210007005592 catalytic residues [active] 210007005593 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 210007005594 MutS domain III; Region: MutS_III; pfam05192 210007005595 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 210007005596 Walker A/P-loop; other site 210007005597 ATP binding site [chemical binding]; other site 210007005598 Q-loop/lid; other site 210007005599 ABC transporter signature motif; other site 210007005600 Walker B; other site 210007005601 D-loop; other site 210007005602 H-loop/switch region; other site 210007005603 Smr domain; Region: Smr; pfam01713 210007005604 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 210007005605 Colicin V production protein; Region: Colicin_V; pfam02674 210007005606 ribonuclease HIII; Provisional; Region: PRK00996 210007005607 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 210007005608 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 210007005609 RNA/DNA hybrid binding site [nucleotide binding]; other site 210007005610 active site 210007005611 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 210007005612 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 210007005613 Catalytic site [active] 210007005614 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 210007005615 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 210007005616 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 210007005617 DNA binding site [nucleotide binding] 210007005618 AAA domain; Region: AAA_30; pfam13604 210007005619 Family description; Region: UvrD_C_2; pfam13538 210007005620 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 210007005621 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 210007005622 active pocket/dimerization site; other site 210007005623 active site 210007005624 phosphorylation site [posttranslational modification] 210007005625 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 210007005626 active site 210007005627 phosphorylation site [posttranslational modification] 210007005628 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 210007005629 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 210007005630 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 210007005631 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 210007005632 putative active site [active] 210007005633 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 210007005634 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 210007005635 Walker A/P-loop; other site 210007005636 ATP binding site [chemical binding]; other site 210007005637 Q-loop/lid; other site 210007005638 ABC transporter signature motif; other site 210007005639 Walker B; other site 210007005640 D-loop; other site 210007005641 H-loop/switch region; other site 210007005642 Domain of unknown function (DUF956); Region: DUF956; pfam06115 210007005643 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 210007005644 Acyltransferase family; Region: Acyl_transf_3; pfam01757 210007005645 seryl-tRNA synthetase; Provisional; Region: PRK05431 210007005646 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 210007005647 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 210007005648 dimer interface [polypeptide binding]; other site 210007005649 active site 210007005650 motif 1; other site 210007005651 motif 2; other site 210007005652 motif 3; other site 210007005653 Integrase core domain; Region: rve_3; cl15866 210007005654 putative transposase OrfB; Reviewed; Region: PHA02517 210007005655 HTH-like domain; Region: HTH_21; pfam13276 210007005656 Integrase core domain; Region: rve; pfam00665 210007005657 Integrase core domain; Region: rve_2; pfam13333 210007005658 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 210007005659 Homeodomain-like domain; Region: HTH_23; cl17451 210007005660 Transposase; Region: HTH_Tnp_1; cl17663 210007005661 COMC family; Region: ComC; pfam03047 210007005662 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 210007005663 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 210007005664 putative active site [active] 210007005665 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 210007005666 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 210007005667 Walker A/P-loop; other site 210007005668 ATP binding site [chemical binding]; other site 210007005669 ABC transporter; Region: ABC_tran; pfam00005 210007005670 Q-loop/lid; other site 210007005671 ABC transporter signature motif; other site 210007005672 Walker B; other site 210007005673 D-loop; other site 210007005674 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 210007005675 HlyD family secretion protein; Region: HlyD_3; pfam13437 210007005676 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 210007005677 catalytic residues [active] 210007005678 COMC family; Region: ComC; pfam03047 210007005679 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 210007005680 COMC family; Region: ComC; pfam03047 210007005681 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 210007005682 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 210007005683 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 210007005684 active site 210007005685 phosphorylation site [posttranslational modification] 210007005686 intermolecular recognition site; other site 210007005687 dimerization interface [polypeptide binding]; other site 210007005688 LytTr DNA-binding domain; Region: LytTR; pfam04397 210007005689 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 210007005690 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 210007005691 GTP-binding protein Der; Reviewed; Region: PRK00093 210007005692 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 210007005693 G1 box; other site 210007005694 GTP/Mg2+ binding site [chemical binding]; other site 210007005695 Switch I region; other site 210007005696 G2 box; other site 210007005697 Switch II region; other site 210007005698 G3 box; other site 210007005699 G4 box; other site 210007005700 G5 box; other site 210007005701 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 210007005702 G1 box; other site 210007005703 GTP/Mg2+ binding site [chemical binding]; other site 210007005704 Switch I region; other site 210007005705 G2 box; other site 210007005706 G3 box; other site 210007005707 Switch II region; other site 210007005708 G4 box; other site 210007005709 G5 box; other site 210007005710 primosomal protein DnaI; Reviewed; Region: PRK08939 210007005711 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 210007005712 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 210007005713 Walker A motif; other site 210007005714 ATP binding site [chemical binding]; other site 210007005715 Walker B motif; other site 210007005716 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 210007005717 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 210007005718 ATP cone domain; Region: ATP-cone; pfam03477 210007005719 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 210007005720 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 210007005721 active site 210007005722 phosphorylation site [posttranslational modification] 210007005723 intermolecular recognition site; other site 210007005724 dimerization interface [polypeptide binding]; other site 210007005725 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 210007005726 DNA binding site [nucleotide binding] 210007005727 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 210007005728 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 210007005729 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 210007005730 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 210007005731 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 210007005732 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 210007005733 Walker A/P-loop; other site 210007005734 ATP binding site [chemical binding]; other site 210007005735 Q-loop/lid; other site 210007005736 ABC transporter signature motif; other site 210007005737 Walker B; other site 210007005738 D-loop; other site 210007005739 H-loop/switch region; other site 210007005740 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 210007005741 FtsX-like permease family; Region: FtsX; pfam02687 210007005742 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 210007005743 FtsX-like permease family; Region: FtsX; pfam02687 210007005744 heat shock protein HtpX; Provisional; Region: PRK04897 210007005745 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 210007005746 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 210007005747 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 210007005748 S-adenosylmethionine binding site [chemical binding]; other site 210007005749 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 210007005750 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 210007005751 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 210007005752 Walker A/P-loop; other site 210007005753 ATP binding site [chemical binding]; other site 210007005754 Q-loop/lid; other site 210007005755 ABC transporter signature motif; other site 210007005756 Walker B; other site 210007005757 D-loop; other site 210007005758 H-loop/switch region; other site 210007005759 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 210007005760 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 210007005761 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 210007005762 Walker A/P-loop; other site 210007005763 ATP binding site [chemical binding]; other site 210007005764 Q-loop/lid; other site 210007005765 ABC transporter signature motif; other site 210007005766 Walker B; other site 210007005767 D-loop; other site 210007005768 H-loop/switch region; other site 210007005769 hypothetical protein; Provisional; Region: PRK13661 210007005770 Uncharacterized conserved protein [Function unknown]; Region: COG1912 210007005771 Predicted amidohydrolase [General function prediction only]; Region: COG0388 210007005772 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583 210007005773 putative active site [active] 210007005774 catalytic triad [active] 210007005775 putative dimer interface [polypeptide binding]; other site 210007005776 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 210007005777 dimer interface [polypeptide binding]; other site 210007005778 conserved gate region; other site 210007005779 ABC-ATPase subunit interface; other site 210007005780 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 210007005781 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 210007005782 Walker A/P-loop; other site 210007005783 ATP binding site [chemical binding]; other site 210007005784 Q-loop/lid; other site 210007005785 ABC transporter signature motif; other site 210007005786 Walker B; other site 210007005787 D-loop; other site 210007005788 H-loop/switch region; other site 210007005789 NIL domain; Region: NIL; pfam09383 210007005790 hypothetical protein; Provisional; Region: PRK06446 210007005791 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 210007005792 metal binding site [ion binding]; metal-binding site 210007005793 dimer interface [polypeptide binding]; other site 210007005794 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 210007005795 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 210007005796 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 210007005797 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 210007005798 substrate binding pocket [chemical binding]; other site 210007005799 membrane-bound complex binding site; other site 210007005800 hinge residues; other site 210007005801 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 210007005802 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 210007005803 HIGH motif; other site 210007005804 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 210007005805 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 210007005806 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 210007005807 active site 210007005808 KMSKS motif; other site 210007005809 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 210007005810 tRNA binding surface [nucleotide binding]; other site 210007005811 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 210007005812 putative metal binding residues [ion binding]; other site 210007005813 signature motif; other site 210007005814 dimer interface [polypeptide binding]; other site 210007005815 active site 210007005816 polyP binding site; other site 210007005817 substrate binding site [chemical binding]; other site 210007005818 acceptor-phosphate pocket; other site 210007005819 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 210007005820 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 210007005821 putative homodimer interface [polypeptide binding]; other site 210007005822 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 210007005823 heterodimer interface [polypeptide binding]; other site 210007005824 homodimer interface [polypeptide binding]; other site 210007005825 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 210007005826 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 210007005827 Transglycosylase; Region: Transgly; pfam00912 210007005828 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 210007005829 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 210007005830 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 210007005831 active site 210007005832 Predicted membrane protein [Function unknown]; Region: COG4640 210007005833 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 210007005834 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 210007005835 ring oligomerisation interface [polypeptide binding]; other site 210007005836 ATP/Mg binding site [chemical binding]; other site 210007005837 stacking interactions; other site 210007005838 hinge regions; other site 210007005839 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 210007005840 oligomerisation interface [polypeptide binding]; other site 210007005841 mobile loop; other site 210007005842 roof hairpin; other site 210007005843 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 210007005844 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 210007005845 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 210007005846 active site 210007005847 phosphorylation site [posttranslational modification] 210007005848 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 210007005849 active pocket/dimerization site; other site 210007005850 active site 210007005851 phosphorylation site [posttranslational modification] 210007005852 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 210007005853 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 210007005854 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 210007005855 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 210007005856 active site 210007005857 phosphorylation site [posttranslational modification] 210007005858 intermolecular recognition site; other site 210007005859 dimerization interface [polypeptide binding]; other site 210007005860 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 210007005861 DNA binding residues [nucleotide binding] 210007005862 dimerization interface [polypeptide binding]; other site 210007005863 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 210007005864 Histidine kinase; Region: HisKA_3; pfam07730 210007005865 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 210007005866 ATP binding site [chemical binding]; other site 210007005867 Mg2+ binding site [ion binding]; other site 210007005868 G-X-G motif; other site 210007005869 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 210007005870 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 210007005871 ligand binding site [chemical binding]; other site 210007005872 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 210007005873 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 210007005874 dimer interface [polypeptide binding]; other site 210007005875 ssDNA binding site [nucleotide binding]; other site 210007005876 tetramer (dimer of dimers) interface [polypeptide binding]; other site 210007005877 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 210007005878 active site residue [active] 210007005879 MarR family; Region: MarR_2; cl17246 210007005880 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 210007005881 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 210007005882 putative tRNA-binding site [nucleotide binding]; other site 210007005883 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 210007005884 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 210007005885 catalytic residues [active] 210007005886 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 210007005887 glutamyl aminopeptidase; Region: glu_aminopep; TIGR03107 210007005888 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 210007005889 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 210007005890 CAAX protease self-immunity; Region: Abi; pfam02517 210007005891 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 210007005892 non-specific DNA binding site [nucleotide binding]; other site 210007005893 salt bridge; other site 210007005894 sequence-specific DNA binding site [nucleotide binding]; other site 210007005895 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 210007005896 propionate/acetate kinase; Provisional; Region: PRK12379 210007005897 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 210007005898 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 210007005899 S-adenosylmethionine binding site [chemical binding]; other site 210007005900 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 210007005901 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 210007005902 Type II secretory pathway pseudopilin; Region: PulG; pfam11773 210007005903 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 210007005904 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 210007005905 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 210007005906 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 210007005907 Type II/IV secretion system protein; Region: T2SE; pfam00437 210007005908 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 210007005909 Walker A motif; other site 210007005910 ATP binding site [chemical binding]; other site 210007005911 Walker B motif; other site 210007005912 Protein of unknown function (DUF1033); Region: DUF1033; pfam06279 210007005913 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 210007005914 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 210007005915 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 210007005916 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 210007005917 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 210007005918 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 210007005919 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 210007005920 G-loop; other site 210007005921 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 210007005922 DNA binding site [nucleotide binding] 210007005923 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 210007005924 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 210007005925 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 210007005926 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 210007005927 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 210007005928 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 210007005929 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 210007005930 RPB1 interaction site [polypeptide binding]; other site 210007005931 RPB10 interaction site [polypeptide binding]; other site 210007005932 RPB11 interaction site [polypeptide binding]; other site 210007005933 RPB3 interaction site [polypeptide binding]; other site 210007005934 RPB12 interaction site [polypeptide binding]; other site 210007005935 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 210007005936 Transglycosylase; Region: Transgly; pfam00912 210007005937 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 210007005938 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 210007005939 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 210007005940 active site 210007005941 HIGH motif; other site 210007005942 dimer interface [polypeptide binding]; other site 210007005943 KMSKS motif; other site 210007005944 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 210007005945 RNA binding surface [nucleotide binding]; other site 210007005946 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 210007005947 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 210007005948 ABC-ATPase subunit interface; other site 210007005949 dimer interface [polypeptide binding]; other site 210007005950 putative PBP binding regions; other site 210007005951 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 210007005952 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 210007005953 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 210007005954 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 210007005955 putative Zn2+ binding site [ion binding]; other site 210007005956 putative DNA binding site [nucleotide binding]; other site 210007005957 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 210007005958 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 210007005959 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 210007005960 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 210007005961 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 210007005962 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 210007005963 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 210007005964 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 210007005965 alphaNTD homodimer interface [polypeptide binding]; other site 210007005966 alphaNTD - beta interaction site [polypeptide binding]; other site 210007005967 alphaNTD - beta' interaction site [polypeptide binding]; other site 210007005968 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 210007005969 30S ribosomal protein S11; Validated; Region: PRK05309 210007005970 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 210007005971 30S ribosomal protein S13; Region: bact_S13; TIGR03631 210007005972 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 210007005973 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 210007005974 rRNA binding site [nucleotide binding]; other site 210007005975 predicted 30S ribosome binding site; other site 210007005976 adenylate kinase; Reviewed; Region: adk; PRK00279 210007005977 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 210007005978 AMP-binding site [chemical binding]; other site 210007005979 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 210007005980 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 210007005981 SecY translocase; Region: SecY; pfam00344 210007005982 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 210007005983 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 210007005984 23S rRNA binding site [nucleotide binding]; other site 210007005985 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 210007005986 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 210007005987 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 210007005988 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 210007005989 5S rRNA interface [nucleotide binding]; other site 210007005990 L27 interface [polypeptide binding]; other site 210007005991 23S rRNA interface [nucleotide binding]; other site 210007005992 L5 interface [polypeptide binding]; other site 210007005993 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 210007005994 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 210007005995 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 210007005996 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 210007005997 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 210007005998 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 210007005999 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 210007006000 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 210007006001 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 210007006002 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 210007006003 RNA binding site [nucleotide binding]; other site 210007006004 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 210007006005 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 210007006006 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 210007006007 23S rRNA interface [nucleotide binding]; other site 210007006008 putative translocon interaction site; other site 210007006009 signal recognition particle (SRP54) interaction site; other site 210007006010 L23 interface [polypeptide binding]; other site 210007006011 trigger factor interaction site; other site 210007006012 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 210007006013 23S rRNA interface [nucleotide binding]; other site 210007006014 5S rRNA interface [nucleotide binding]; other site 210007006015 putative antibiotic binding site [chemical binding]; other site 210007006016 L25 interface [polypeptide binding]; other site 210007006017 L27 interface [polypeptide binding]; other site 210007006018 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 210007006019 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 210007006020 G-X-X-G motif; other site 210007006021 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 210007006022 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 210007006023 putative translocon binding site; other site 210007006024 protein-rRNA interface [nucleotide binding]; other site 210007006025 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 210007006026 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 210007006027 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 210007006028 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 210007006029 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 210007006030 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 210007006031 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 210007006032 Ribosomal protein S10p/S20e; Region: Ribosomal_S10; cl00314 210007006033 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 210007006034 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 210007006035 non-specific DNA binding site [nucleotide binding]; other site 210007006036 salt bridge; other site 210007006037 sequence-specific DNA binding site [nucleotide binding]; other site 210007006038 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 210007006039 Catalytic site [active] 210007006040 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 210007006041 Glycosyl hydrolase family 68, includes levansucrase, beta-fructofuranosidase and inulosucrase; Region: GH68; cd08997 210007006042 active site 210007006043 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 210007006044 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 210007006045 Walker A motif; other site 210007006046 ATP binding site [chemical binding]; other site 210007006047 Walker B motif; other site 210007006048 arginine finger; other site 210007006049 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 210007006050 Walker A motif; other site 210007006051 ATP binding site [chemical binding]; other site 210007006052 Walker B motif; other site 210007006053 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 210007006054 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 210007006055 elongation factor Ts; Provisional; Region: tsf; PRK09377 210007006056 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 210007006057 Elongation factor TS; Region: EF_TS; pfam00889 210007006058 Elongation factor TS; Region: EF_TS; pfam00889 210007006059 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 210007006060 rRNA interaction site [nucleotide binding]; other site 210007006061 S8 interaction site; other site 210007006062 putative laminin-1 binding site; other site 210007006063 Predicted integral membrane protein [Function unknown]; Region: COG5617 210007006064 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 210007006065 putative dimer interface [polypeptide binding]; other site 210007006066 catalytic triad [active] 210007006067 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 210007006068 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 210007006069 active site 210007006070 Zn binding site [ion binding]; other site 210007006071 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 210007006072 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 210007006073 Ca binding site [ion binding]; other site 210007006074 active site 210007006075 catalytic site [active] 210007006076 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 210007006077 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 210007006078 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 210007006079 active site turn [active] 210007006080 phosphorylation site [posttranslational modification] 210007006081 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 210007006082 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 210007006083 HPr interaction site; other site 210007006084 glycerol kinase (GK) interaction site [polypeptide binding]; other site 210007006085 active site 210007006086 phosphorylation site [posttranslational modification] 210007006087 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 210007006088 DNA-binding site [nucleotide binding]; DNA binding site 210007006089 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 210007006090 UTRA domain; Region: UTRA; pfam07702 210007006091 Glycosyl hydrolase family 66; Region: Glyco_hydro_66; pfam13199 210007006092 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 210007006093 putative active site [active] 210007006094 dimerization interface [polypeptide binding]; other site 210007006095 putative tRNAtyr binding site [nucleotide binding]; other site 210007006096 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 210007006097 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 210007006098 Zn2+ binding site [ion binding]; other site 210007006099 Mg2+ binding site [ion binding]; other site 210007006100 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 210007006101 synthetase active site [active] 210007006102 NTP binding site [chemical binding]; other site 210007006103 metal binding site [ion binding]; metal-binding site 210007006104 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 210007006105 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 210007006106 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 210007006107 putative catalytic site [active] 210007006108 putative metal binding site [ion binding]; other site 210007006109 putative phosphate binding site [ion binding]; other site 210007006110 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 210007006111 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 210007006112 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 210007006113 active site turn [active] 210007006114 phosphorylation site [posttranslational modification] 210007006115 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 210007006116 HPr interaction site; other site 210007006117 glycerol kinase (GK) interaction site [polypeptide binding]; other site 210007006118 active site 210007006119 phosphorylation site [posttranslational modification] 210007006120 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 210007006121 RNA methyltransferase, RsmE family; Region: TIGR00046 210007006122 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 210007006123 Methyltransferase domain; Region: Methyltransf_18; pfam12847 210007006124 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 210007006125 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 210007006126 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 210007006127 Coenzyme A binding pocket [chemical binding]; other site 210007006128 recombination factor protein RarA; Reviewed; Region: PRK13342 210007006129 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 210007006130 Walker A motif; other site 210007006131 ATP binding site [chemical binding]; other site 210007006132 Walker B motif; other site 210007006133 arginine finger; other site 210007006134 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 210007006135 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 210007006136 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 210007006137 Soluble P-type ATPase [General function prediction only]; Region: COG4087 210007006138 Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107 210007006139 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 210007006140 DNA binding residues [nucleotide binding] 210007006141 drug binding residues [chemical binding]; other site 210007006142 dimer interface [polypeptide binding]; other site 210007006143 Predicted membrane protein [Function unknown]; Region: COG2855 210007006144 Transcriptional regulator [Transcription]; Region: LysR; COG0583 210007006145 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 210007006146 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 210007006147 putative dimerization interface [polypeptide binding]; other site 210007006148 ferrochelatase; Reviewed; Region: hemH; PRK00035 210007006149 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 210007006150 C-terminal domain interface [polypeptide binding]; other site 210007006151 active site 210007006152 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 210007006153 active site 210007006154 N-terminal domain interface [polypeptide binding]; other site 210007006155 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 210007006156 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 210007006157 UDP-glucose 4-epimerase; Region: PLN02240 210007006158 NAD binding site [chemical binding]; other site 210007006159 homodimer interface [polypeptide binding]; other site 210007006160 active site 210007006161 substrate binding site [chemical binding]; other site 210007006162 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 210007006163 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 210007006164 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 210007006165 Ligand binding site; other site 210007006166 Putative Catalytic site; other site 210007006167 DXD motif; other site 210007006168 zinc transporter ZupT; Provisional; Region: PRK04201 210007006169 ZIP Zinc transporter; Region: Zip; pfam02535 210007006170 hypothetical protein; Validated; Region: PRK02101 210007006171 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 210007006172 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 210007006173 FeS/SAM binding site; other site 210007006174 Predicted acetyltransferase [General function prediction only]; Region: COG3981 210007006175 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 210007006176 Coenzyme A binding pocket [chemical binding]; other site 210007006177 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 210007006178 ATP cone domain; Region: ATP-cone; pfam03477 210007006179 Class III ribonucleotide reductase; Region: RNR_III; cd01675 210007006180 effector binding site; other site 210007006181 active site 210007006182 Zn binding site [ion binding]; other site 210007006183 glycine loop; other site 210007006184 Predicted membrane protein (DUF2079); Region: DUF2079; pfam09852 210007006185 hypothetical protein; Provisional; Region: PRK13678 210007006186 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 210007006187 hypothetical protein; Provisional; Region: PRK05473 210007006188 LytTr DNA-binding domain; Region: LytTR; pfam04397 210007006189 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 210007006190 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 210007006191 ArsC family; Region: ArsC; pfam03960 210007006192 putative catalytic residues [active] 210007006193 thiol/disulfide switch; other site 210007006194 recombinase A; Provisional; Region: recA; PRK09354 210007006195 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 210007006196 hexamer interface [polypeptide binding]; other site 210007006197 Walker A motif; other site 210007006198 ATP binding site [chemical binding]; other site 210007006199 Walker B motif; other site 210007006200 competence damage-inducible protein A; Provisional; Region: PRK00549 210007006201 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 210007006202 putative MPT binding site; other site 210007006203 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 210007006204 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 210007006205 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 210007006206 RuvA N terminal domain; Region: RuvA_N; pfam01330 210007006207 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 210007006208 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 210007006209 ATP binding site [chemical binding]; other site 210007006210 Mg2+ binding site [ion binding]; other site 210007006211 G-X-G motif; other site 210007006212 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 210007006213 ATP binding site [chemical binding]; other site 210007006214 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 210007006215 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 210007006216 MutS domain I; Region: MutS_I; pfam01624 210007006217 MutS domain II; Region: MutS_II; pfam05188 210007006218 MutS domain III; Region: MutS_III; pfam05192 210007006219 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 210007006220 Walker A/P-loop; other site 210007006221 ATP binding site [chemical binding]; other site 210007006222 Q-loop/lid; other site 210007006223 ABC transporter signature motif; other site 210007006224 Walker B; other site 210007006225 D-loop; other site 210007006226 H-loop/switch region; other site 210007006227 Protein of unknown function (DUF964); Region: DUF964; cl01483 210007006228 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 210007006229 arginine repressor; Region: argR_whole; TIGR01529 210007006230 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 210007006231 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 210007006232 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 210007006233 ligand binding site [chemical binding]; other site 210007006234 flexible hinge region; other site 210007006235 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 210007006236 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 210007006237 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 210007006238 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 210007006239 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 210007006240 active site 210007006241 HIGH motif; other site 210007006242 KMSK motif region; other site 210007006243 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 210007006244 tRNA binding surface [nucleotide binding]; other site 210007006245 anticodon binding site; other site 210007006246 Uncharacterized conserved protein [Function unknown]; Region: COG1284 210007006247 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 210007006248 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 210007006249 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 210007006250 Uncharacterized conserved protein [Function unknown]; Region: COG1284 210007006251 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 210007006252 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 210007006253 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 210007006254 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 210007006255 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 210007006256 dimer interface [polypeptide binding]; other site 210007006257 anticodon binding site; other site 210007006258 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 210007006259 homodimer interface [polypeptide binding]; other site 210007006260 motif 1; other site 210007006261 active site 210007006262 motif 2; other site 210007006263 GAD domain; Region: GAD; pfam02938 210007006264 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 210007006265 motif 3; other site 210007006266 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 210007006267 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 210007006268 dimer interface [polypeptide binding]; other site 210007006269 motif 1; other site 210007006270 active site 210007006271 motif 2; other site 210007006272 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 210007006273 anticodon binding site; other site 210007006274 Amino acid permease; Region: AA_permease_2; pfam13520 210007006275 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 210007006276 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 210007006277 NAD binding site [chemical binding]; other site 210007006278 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 210007006279 dimerization interface [polypeptide binding]; other site 210007006280 putative DNA binding site [nucleotide binding]; other site 210007006281 putative Zn2+ binding site [ion binding]; other site 210007006282 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 210007006283 putative substrate translocation pore; other site 210007006284 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 210007006285 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 210007006286 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 210007006287 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 210007006288 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 210007006289 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 210007006290 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 210007006291 catalytic core [active] 210007006292 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 210007006293 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 210007006294 DNA binding residues [nucleotide binding] 210007006295 putative dimer interface [polypeptide binding]; other site 210007006296 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 210007006297 classical (c) SDRs; Region: SDR_c; cd05233 210007006298 NAD(P) binding site [chemical binding]; other site 210007006299 active site 210007006300 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 210007006301 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 210007006302 Walker A/P-loop; other site 210007006303 ATP binding site [chemical binding]; other site 210007006304 Q-loop/lid; other site 210007006305 ABC transporter signature motif; other site 210007006306 Walker B; other site 210007006307 D-loop; other site 210007006308 H-loop/switch region; other site 210007006309 FOG: CBS domain [General function prediction only]; Region: COG0517 210007006310 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 210007006311 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 210007006312 dimer interface [polypeptide binding]; other site 210007006313 conserved gate region; other site 210007006314 putative PBP binding loops; other site 210007006315 ABC-ATPase subunit interface; other site 210007006316 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 210007006317 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 210007006318 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 210007006319 dimer interface [polypeptide binding]; other site 210007006320 conserved gate region; other site 210007006321 ABC-ATPase subunit interface; other site 210007006322 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 210007006323 active site 210007006324 DNA binding site [nucleotide binding] 210007006325 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2350 210007006326 Predicted transcriptional regulators [Transcription]; Region: COG1733 210007006327 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 210007006328 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 210007006329 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 210007006330 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 210007006331 NAD(P) binding site [chemical binding]; other site 210007006332 catalytic residues [active] 210007006333 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 210007006334 Domain of unknown function DUF59; Region: DUF59; cl00941 210007006335 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 210007006336 gating phenylalanine in ion channel; other site 210007006337 Predicted membrane protein [Function unknown]; Region: COG1511 210007006338 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 210007006339 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 210007006340 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 210007006341 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 210007006342 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 210007006343 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 210007006344 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 210007006345 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 210007006346 RNA binding surface [nucleotide binding]; other site 210007006347 Uncharacterized protein conserved in bacteria [Function unknown]; Region: Veg; COG4466 210007006348 replicative DNA helicase; Provisional; Region: PRK05748 210007006349 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 210007006350 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 210007006351 Walker A motif; other site 210007006352 ATP binding site [chemical binding]; other site 210007006353 Walker B motif; other site 210007006354 DNA binding loops [nucleotide binding] 210007006355 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 210007006356 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 210007006357 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 210007006358 hypothetical protein; Provisional; Region: PRK09273 210007006359 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 210007006360 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 210007006361 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 210007006362 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 210007006363 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 210007006364 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 210007006365 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13649 210007006366 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 210007006367 Walker A/P-loop; other site 210007006368 ATP binding site [chemical binding]; other site 210007006369 Q-loop/lid; other site 210007006370 ABC transporter signature motif; other site 210007006371 Walker B; other site 210007006372 D-loop; other site 210007006373 H-loop/switch region; other site 210007006374 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13650 210007006375 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 210007006376 Walker A/P-loop; other site 210007006377 ATP binding site [chemical binding]; other site 210007006378 Q-loop/lid; other site 210007006379 ABC transporter signature motif; other site 210007006380 Walker B; other site 210007006381 D-loop; other site 210007006382 H-loop/switch region; other site 210007006383 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 210007006384 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 210007006385 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 210007006386 non-specific DNA binding site [nucleotide binding]; other site 210007006387 salt bridge; other site 210007006388 sequence-specific DNA binding site [nucleotide binding]; other site 210007006389 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 210007006390 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 210007006391 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 210007006392 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 210007006393 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 210007006394 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 210007006395 recombination protein F; Reviewed; Region: recF; PRK00064 210007006396 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 210007006397 Walker A/P-loop; other site 210007006398 ATP binding site [chemical binding]; other site 210007006399 Q-loop/lid; other site 210007006400 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 210007006401 ABC transporter signature motif; other site 210007006402 Walker B; other site 210007006403 D-loop; other site 210007006404 H-loop/switch region; other site 210007006405 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 210007006406 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 210007006407 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 210007006408 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 210007006409 active site 210007006410 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 210007006411 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 210007006412 active site 210007006413 HIGH motif; other site 210007006414 dimer interface [polypeptide binding]; other site 210007006415 KMSKS motif; other site 210007006416 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 210007006417 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 210007006418 Walker A/P-loop; other site 210007006419 ATP binding site [chemical binding]; other site 210007006420 Q-loop/lid; other site 210007006421 ABC transporter signature motif; other site 210007006422 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 210007006423 Walker B; other site 210007006424 D-loop; other site 210007006425 H-loop/switch region; other site 210007006426 ABC transporter; Region: ABC_tran_2; pfam12848 210007006427 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 210007006428 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 210007006429 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 210007006430 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 210007006431 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 210007006432 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 210007006433 protein binding site [polypeptide binding]; other site 210007006434 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 210007006435 ParB-like nuclease domain; Region: ParBc; pfam02195 210007006436 Sugar-specific transcriptional regulator TrmB; Region: TrmB; cl17775