-- dump date 20140620_083213 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1302863000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 1302863000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1302863000003 Walker A motif; other site 1302863000004 ATP binding site [chemical binding]; other site 1302863000005 Walker B motif; other site 1302863000006 arginine finger; other site 1302863000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1302863000008 DnaA box-binding interface [nucleotide binding]; other site 1302863000009 DNA polymerase III subunit beta; Validated; Region: PRK05643 1302863000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1302863000011 putative DNA binding surface [nucleotide binding]; other site 1302863000012 dimer interface [polypeptide binding]; other site 1302863000013 beta-clamp/clamp loader binding surface; other site 1302863000014 beta-clamp/translesion DNA polymerase binding surface; other site 1302863000015 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 1302863000016 Protein of unknown function (DUF1307); Region: DUF1307; cl01981 1302863000017 GTP-binding protein YchF; Reviewed; Region: PRK09601 1302863000018 YchF GTPase; Region: YchF; cd01900 1302863000019 G1 box; other site 1302863000020 GTP/Mg2+ binding site [chemical binding]; other site 1302863000021 Switch I region; other site 1302863000022 G2 box; other site 1302863000023 Switch II region; other site 1302863000024 G3 box; other site 1302863000025 G4 box; other site 1302863000026 G5 box; other site 1302863000027 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1302863000028 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1302863000029 putative active site [active] 1302863000030 catalytic residue [active] 1302863000031 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 1302863000032 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1302863000033 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1302863000034 ATP binding site [chemical binding]; other site 1302863000035 putative Mg++ binding site [ion binding]; other site 1302863000036 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1302863000037 nucleotide binding region [chemical binding]; other site 1302863000038 ATP-binding site [chemical binding]; other site 1302863000039 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1302863000040 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1302863000041 RNA binding surface [nucleotide binding]; other site 1302863000042 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1302863000043 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1302863000044 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1302863000045 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1302863000046 Ligand Binding Site [chemical binding]; other site 1302863000047 TilS substrate C-terminal domain; Region: TilS_C; smart00977 1302863000048 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1302863000049 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1302863000050 active site 1302863000051 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 1302863000052 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1302863000053 Walker A motif; other site 1302863000054 ATP binding site [chemical binding]; other site 1302863000055 Walker B motif; other site 1302863000056 arginine finger; other site 1302863000057 Peptidase family M41; Region: Peptidase_M41; pfam01434 1302863000058 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1302863000059 rod shape-determining protein MreC; Provisional; Region: PRK13922 1302863000060 rod shape-determining protein MreC; Region: MreC; pfam04085 1302863000061 rod shape-determining protein MreD; Region: MreD; cl01087 1302863000062 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 1302863000063 CHD5-like protein; Region: CHD5; pfam04420 1302863000064 Surface antigen [General function prediction only]; Region: COG3942 1302863000065 CHAP domain; Region: CHAP; pfam05257 1302863000066 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269 1302863000067 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1302863000068 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1302863000069 active site 1302863000070 aromatic amino acid aminotransferase; Validated; Region: PRK07309 1302863000071 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1302863000072 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302863000073 homodimer interface [polypeptide binding]; other site 1302863000074 catalytic residue [active] 1302863000075 Recombination protein O N terminal; Region: RecO_N; pfam11967 1302863000076 DNA repair protein RecO; Region: reco; TIGR00613 1302863000077 Recombination protein O C terminal; Region: RecO_C; pfam02565 1302863000078 putative phosphate acyltransferase; Provisional; Region: PRK05331 1302863000079 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1302863000080 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 1302863000081 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 1302863000082 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 1302863000083 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 1302863000084 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 1302863000085 Surface antigen [General function prediction only]; Region: COG3942 1302863000086 CHAP domain; Region: CHAP; pfam05257 1302863000087 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1302863000088 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1302863000089 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1302863000090 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1302863000091 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1302863000092 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1302863000093 ATP-grasp domain; Region: ATP-grasp; pfam02222 1302863000094 aspartate racemase; Region: asp_race; TIGR00035 1302863000095 Aspartate racemase [Cell envelope biogenesis, outer membrane]; Region: RacX; COG1794 1302863000096 adenylosuccinate lyase; Provisional; Region: PRK07492 1302863000097 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 1302863000098 tetramer interface [polypeptide binding]; other site 1302863000099 active site 1302863000100 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1302863000101 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1302863000102 DNA-binding site [nucleotide binding]; DNA binding site 1302863000103 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1302863000104 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 1302863000105 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 1302863000106 Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364 1302863000107 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1302863000108 active site 1302863000109 phosphorylation site [posttranslational modification] 1302863000110 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 1302863000111 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 1302863000112 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1302863000113 active pocket/dimerization site; other site 1302863000114 active site 1302863000115 phosphorylation site [posttranslational modification] 1302863000116 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 1302863000117 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1302863000118 dimer interface [polypeptide binding]; other site 1302863000119 active site 1302863000120 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 1302863000121 putative active site [active] 1302863000122 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1302863000123 active site 1302863000124 catalytic residues [active] 1302863000125 yiaA/B two helix domain; Region: YiaAB; pfam05360 1302863000126 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1302863000127 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1302863000128 Walker A motif; other site 1302863000129 ATP binding site [chemical binding]; other site 1302863000130 Walker B motif; other site 1302863000131 arginine finger; other site 1302863000132 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1302863000133 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1302863000134 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1302863000135 active site 1302863000136 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 1302863000137 MORN repeat; Region: MORN; cl14787 1302863000138 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1302863000139 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1302863000140 active site 1302863000141 catalytic triad [active] 1302863000142 oxyanion hole [active] 1302863000143 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1302863000144 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1302863000145 putative catalytic cysteine [active] 1302863000146 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1302863000147 putative active site [active] 1302863000148 metal binding site [ion binding]; metal-binding site 1302863000149 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1302863000150 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1302863000151 non-specific DNA binding site [nucleotide binding]; other site 1302863000152 salt bridge; other site 1302863000153 sequence-specific DNA binding site [nucleotide binding]; other site 1302863000154 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1302863000155 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1302863000156 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 1302863000157 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1302863000158 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 1302863000159 putative active site cavity [active] 1302863000160 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1302863000161 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1302863000162 Walker A/P-loop; other site 1302863000163 ATP binding site [chemical binding]; other site 1302863000164 Q-loop/lid; other site 1302863000165 ABC transporter signature motif; other site 1302863000166 Walker B; other site 1302863000167 D-loop; other site 1302863000168 H-loop/switch region; other site 1302863000169 TOBE domain; Region: TOBE_2; pfam08402 1302863000170 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1302863000171 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1302863000172 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1302863000173 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1302863000174 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302863000175 putative PBP binding loops; other site 1302863000176 dimer interface [polypeptide binding]; other site 1302863000177 ABC-ATPase subunit interface; other site 1302863000178 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1302863000179 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302863000180 dimer interface [polypeptide binding]; other site 1302863000181 conserved gate region; other site 1302863000182 putative PBP binding loops; other site 1302863000183 ABC-ATPase subunit interface; other site 1302863000184 Domain of unknown function (DUF386); Region: DUF386; pfam04074 1302863000185 Protein of unknown function, DUF624; Region: DUF624; pfam04854 1302863000186 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1302863000187 Class I aldolases; Region: Aldolase_Class_I; cl17187 1302863000188 catalytic residue [active] 1302863000189 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1302863000190 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1302863000191 nucleotide binding site [chemical binding]; other site 1302863000192 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 1302863000193 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1302863000194 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1302863000195 putative active site [active] 1302863000196 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1302863000197 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1302863000198 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1302863000199 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1302863000200 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302863000201 catalytic residue [active] 1302863000202 ribonuclease; Region: Ribonuclease; pfam00545 1302863000203 active site 1302863000204 GAD-like domain; Region: GAD-like; pfam08887 1302863000205 Domain of unknown function (DUF1851); Region: DUF1851; pfam08906 1302863000206 Protein of unknown function, DUF600; Region: DUF600; cl04640 1302863000207 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1302863000208 Protein of unknown function, DUF600; Region: DUF600; cl04640 1302863000209 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1302863000210 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 1302863000211 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1302863000212 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1302863000213 motif II; other site 1302863000214 YcxB-like protein; Region: YcxB; pfam14317 1302863000215 DNA polymerase I; Provisional; Region: PRK05755 1302863000216 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1302863000217 active site 1302863000218 metal binding site 1 [ion binding]; metal-binding site 1302863000219 putative 5' ssDNA interaction site; other site 1302863000220 metal binding site 3; metal-binding site 1302863000221 metal binding site 2 [ion binding]; metal-binding site 1302863000222 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1302863000223 putative DNA binding site [nucleotide binding]; other site 1302863000224 putative metal binding site [ion binding]; other site 1302863000225 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 1302863000226 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1302863000227 active site 1302863000228 DNA binding site [nucleotide binding] 1302863000229 catalytic site [active] 1302863000230 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1302863000231 hypothetical protein; Provisional; Region: PRK06762 1302863000232 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 1302863000233 SecA binding site; other site 1302863000234 Preprotein binding site; other site 1302863000235 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 1302863000236 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 1302863000237 Protein of unknown function (DUF975); Region: DUF975; cl10504 1302863000238 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1302863000239 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1302863000240 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1302863000241 active site 1302863000242 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1302863000243 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1302863000244 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1302863000245 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1302863000246 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1302863000247 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1302863000248 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1302863000249 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1302863000250 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1302863000251 putative translocon binding site; other site 1302863000252 protein-rRNA interface [nucleotide binding]; other site 1302863000253 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1302863000254 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1302863000255 G-X-X-G motif; other site 1302863000256 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1302863000257 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1302863000258 23S rRNA interface [nucleotide binding]; other site 1302863000259 5S rRNA interface [nucleotide binding]; other site 1302863000260 putative antibiotic binding site [chemical binding]; other site 1302863000261 L25 interface [polypeptide binding]; other site 1302863000262 L27 interface [polypeptide binding]; other site 1302863000263 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1302863000264 23S rRNA interface [nucleotide binding]; other site 1302863000265 putative translocon interaction site; other site 1302863000266 signal recognition particle (SRP54) interaction site; other site 1302863000267 L23 interface [polypeptide binding]; other site 1302863000268 trigger factor interaction site; other site 1302863000269 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1302863000270 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1302863000271 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1302863000272 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1302863000273 RNA binding site [nucleotide binding]; other site 1302863000274 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1302863000275 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1302863000276 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1302863000277 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 1302863000278 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1302863000279 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1302863000280 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1302863000281 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1302863000282 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1302863000283 5S rRNA interface [nucleotide binding]; other site 1302863000284 L27 interface [polypeptide binding]; other site 1302863000285 23S rRNA interface [nucleotide binding]; other site 1302863000286 L5 interface [polypeptide binding]; other site 1302863000287 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1302863000288 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1302863000289 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1302863000290 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1302863000291 23S rRNA binding site [nucleotide binding]; other site 1302863000292 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1302863000293 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1302863000294 SecY translocase; Region: SecY; pfam00344 1302863000295 adenylate kinase; Reviewed; Region: adk; PRK00279 1302863000296 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1302863000297 AMP-binding site [chemical binding]; other site 1302863000298 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1302863000299 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1302863000300 rRNA binding site [nucleotide binding]; other site 1302863000301 predicted 30S ribosome binding site; other site 1302863000302 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 1302863000303 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 1302863000304 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1302863000305 30S ribosomal protein S11; Validated; Region: PRK05309 1302863000306 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1302863000307 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1302863000308 alphaNTD homodimer interface [polypeptide binding]; other site 1302863000309 alphaNTD - beta interaction site [polypeptide binding]; other site 1302863000310 alphaNTD - beta' interaction site [polypeptide binding]; other site 1302863000311 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1302863000312 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1302863000313 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 1302863000314 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1302863000315 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1302863000316 putative Zn2+ binding site [ion binding]; other site 1302863000317 putative DNA binding site [nucleotide binding]; other site 1302863000318 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1302863000319 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1302863000320 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1302863000321 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1302863000322 ABC-ATPase subunit interface; other site 1302863000323 dimer interface [polypeptide binding]; other site 1302863000324 putative PBP binding regions; other site 1302863000325 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1302863000326 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 1302863000327 metal binding site [ion binding]; metal-binding site 1302863000328 YodA lipocalin-like domain; Region: YodA; pfam09223 1302863000329 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 1302863000330 Penicillinase repressor; Region: Pencillinase_R; pfam03965 1302863000331 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 1302863000332 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1302863000333 metal-binding site [ion binding] 1302863000334 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1302863000335 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1302863000336 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1302863000337 metal-binding site [ion binding] 1302863000338 potential frameshift: common BLAST hit: gi|125717026|ref|YP_001034159.1| sugar ABC transporter ATP-binding protein 1302863000339 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1302863000340 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1302863000341 S-adenosylmethionine binding site [chemical binding]; other site 1302863000342 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1302863000343 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1302863000344 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1302863000345 motif II; other site 1302863000346 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1302863000347 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1302863000348 active site 1302863000349 HIGH motif; other site 1302863000350 dimer interface [polypeptide binding]; other site 1302863000351 KMSKS motif; other site 1302863000352 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1302863000353 RNA binding surface [nucleotide binding]; other site 1302863000354 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 1302863000355 Transglycosylase; Region: Transgly; pfam00912 1302863000356 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1302863000357 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1302863000358 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1302863000359 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1302863000360 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1302863000361 RPB1 interaction site [polypeptide binding]; other site 1302863000362 RPB10 interaction site [polypeptide binding]; other site 1302863000363 RPB11 interaction site [polypeptide binding]; other site 1302863000364 RPB3 interaction site [polypeptide binding]; other site 1302863000365 RPB12 interaction site [polypeptide binding]; other site 1302863000366 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 1302863000367 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1302863000368 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1302863000369 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1302863000370 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1302863000371 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1302863000372 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 1302863000373 G-loop; other site 1302863000374 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1302863000375 DNA binding site [nucleotide binding] 1302863000376 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1302863000377 potential frameshift: common BLAST hit: gi|125717072|ref|YP_001034205.1| CAAX amino terminal protease family protein 1302863000378 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1302863000379 dihydropteroate synthase; Region: DHPS; TIGR01496 1302863000380 substrate binding pocket [chemical binding]; other site 1302863000381 dimer interface [polypeptide binding]; other site 1302863000382 inhibitor binding site; inhibition site 1302863000383 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1302863000384 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1302863000385 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1302863000386 GTP cyclohydrolase I; Provisional; Region: folE; PRK09347 1302863000387 active site 1302863000388 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1302863000389 homooctamer interface [polypeptide binding]; other site 1302863000390 active site 1302863000391 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1302863000392 catalytic center binding site [active] 1302863000393 ATP binding site [chemical binding]; other site 1302863000394 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1302863000395 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1302863000396 Walker A/P-loop; other site 1302863000397 ATP binding site [chemical binding]; other site 1302863000398 Q-loop/lid; other site 1302863000399 ABC transporter signature motif; other site 1302863000400 Walker B; other site 1302863000401 D-loop; other site 1302863000402 H-loop/switch region; other site 1302863000403 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1302863000404 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1302863000405 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302863000406 active site 1302863000407 phosphorylation site [posttranslational modification] 1302863000408 intermolecular recognition site; other site 1302863000409 dimerization interface [polypeptide binding]; other site 1302863000410 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1302863000411 DNA binding site [nucleotide binding] 1302863000412 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1302863000413 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1302863000414 dimer interface [polypeptide binding]; other site 1302863000415 phosphorylation site [posttranslational modification] 1302863000416 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302863000417 ATP binding site [chemical binding]; other site 1302863000418 Mg2+ binding site [ion binding]; other site 1302863000419 G-X-G motif; other site 1302863000420 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1302863000421 non-specific DNA binding site [nucleotide binding]; other site 1302863000422 salt bridge; other site 1302863000423 sequence-specific DNA binding site [nucleotide binding]; other site 1302863000424 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 1302863000425 hypothetical protein; Provisional; Region: PRK13663 1302863000426 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1302863000427 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 1302863000428 oligomer interface [polypeptide binding]; other site 1302863000429 active site 1302863000430 metal binding site [ion binding]; metal-binding site 1302863000431 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1302863000432 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1302863000433 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1302863000434 catalytic residues [active] 1302863000435 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1302863000436 putative tRNA-binding site [nucleotide binding]; other site 1302863000437 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1302863000438 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1302863000439 dimer interface [polypeptide binding]; other site 1302863000440 ssDNA binding site [nucleotide binding]; other site 1302863000441 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1302863000442 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4842 1302863000443 Domain of unknown function (DUF4176); Region: DUF4176; cl01867 1302863000444 LXG domain of WXG superfamily; Region: LXG; pfam04740 1302863000445 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 1302863000446 potential frameshift: common BLAST hit: gi|386337211|ref|YP_006033380.1| transposase, Gram-positive bacteria 1302863000447 Domain of unknown function (DUF4176); Region: DUF4176; cl01867 1302863000448 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 1302863000449 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868 1302863000450 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 1302863000451 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1302863000452 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1302863000453 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1302863000454 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 1302863000455 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1302863000456 Zn2+ binding site [ion binding]; other site 1302863000457 Mg2+ binding site [ion binding]; other site 1302863000458 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1302863000459 synthetase active site [active] 1302863000460 NTP binding site [chemical binding]; other site 1302863000461 metal binding site [ion binding]; metal-binding site 1302863000462 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1302863000463 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1302863000464 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1302863000465 putative active site [active] 1302863000466 dimerization interface [polypeptide binding]; other site 1302863000467 putative tRNAtyr binding site [nucleotide binding]; other site 1302863000468 potential frameshift: common BLAST hit: gi|157149664|ref|YP_001450226.1| CDP-diglyceride synthetase 1302863000469 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1302863000470 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1302863000471 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1302863000472 CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473 1302863000473 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 1302863000474 prenyltransferase; Provisional; Region: ubiA; PRK13592 1302863000475 UbiA prenyltransferase family; Region: UbiA; pfam01040 1302863000476 phosphoenolpyruvate synthase; Validated; Region: PRK06241 1302863000477 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1302863000478 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1302863000479 G5 domain; Region: G5; pfam07501 1302863000480 zinc metalloproteinase 18-residue repeat; Region: zmp_18_rpt; TIGR04227 1302863000481 zinc metalloproteinase 18-residue repeat; Region: zmp_18_rpt; TIGR04227 1302863000482 zinc metalloproteinase 18-residue repeat; Region: zmp_18_rpt; TIGR04227 1302863000483 zinc metalloproteinase 18-residue repeat; Region: zmp_18_rpt; TIGR04227 1302863000484 zinc metalloproteinase 18-residue repeat; Region: zmp_18_rpt; TIGR04227 1302863000485 zinc metalloproteinase 18-residue repeat; Region: zmp_18_rpt; TIGR04227 1302863000486 zinc metalloproteinase 18-residue repeat; Region: zmp_18_rpt; TIGR04227 1302863000487 zinc metalloproteinase 18-residue repeat; Region: zmp_18_rpt; TIGR04227 1302863000488 zinc metalloproteinase 18-residue repeat; Region: zmp_18_rpt; TIGR04227 1302863000489 zinc metalloproteinase 18-residue repeat; Region: zmp_18_rpt; TIGR04227 1302863000490 zinc metalloproteinase 18-residue repeat; Region: zmp_18_rpt; TIGR04227 1302863000491 zinc metalloproteinase 18-residue repeat; Region: zmp_18_rpt; TIGR04227 1302863000492 zinc metalloproteinase 18-residue repeat; Region: zmp_18_rpt; TIGR04227 1302863000493 zinc metalloproteinase 18-residue repeat; Region: zmp_18_rpt; TIGR04227 1302863000494 G5 domain; Region: G5; pfam07501 1302863000495 G5 domain; Region: G5; pfam07501 1302863000496 G5 domain; Region: G5; pfam07501 1302863000497 G5 domain; Region: G5; pfam07501 1302863000498 G5 domain; Region: G5; pfam07501 1302863000499 M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342 1302863000500 M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580 1302863000501 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1302863000502 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1302863000503 Coenzyme A binding pocket [chemical binding]; other site 1302863000504 hypothetical protein; Provisional; Region: PRK02268 1302863000505 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1302863000506 MarR family; Region: MarR; pfam01047 1302863000507 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1302863000508 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1302863000509 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1302863000510 FeoA domain; Region: FeoA; pfam04023 1302863000511 Protein of unknown function (DUF3114); Region: DUF3114; pfam11311 1302863000512 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1302863000513 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1302863000514 active site 1302863000515 motif I; other site 1302863000516 motif II; other site 1302863000517 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1302863000518 NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841 1302863000519 active site 1302863000520 catalytic triad [active] 1302863000521 oxyanion hole [active] 1302863000522 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1302863000523 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1302863000524 Coenzyme A binding pocket [chemical binding]; other site 1302863000525 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1302863000526 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 1302863000527 PYR/PP interface [polypeptide binding]; other site 1302863000528 dimer interface [polypeptide binding]; other site 1302863000529 tetramer interface [polypeptide binding]; other site 1302863000530 TPP binding site [chemical binding]; other site 1302863000531 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1302863000532 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1302863000533 TPP-binding site [chemical binding]; other site 1302863000534 potential frameshift: common BLAST hit: gi|157151619|ref|YP_001449616.1| 6-phospho-beta-glucosidase 1302863000535 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1302863000536 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302863000537 active site 1302863000538 phosphorylation site [posttranslational modification] 1302863000539 intermolecular recognition site; other site 1302863000540 dimerization interface [polypeptide binding]; other site 1302863000541 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1302863000542 DNA binding site [nucleotide binding] 1302863000543 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1302863000544 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1302863000545 dimer interface [polypeptide binding]; other site 1302863000546 phosphorylation site [posttranslational modification] 1302863000547 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1302863000548 ATP binding site [chemical binding]; other site 1302863000549 Mg2+ binding site [ion binding]; other site 1302863000550 G-X-G motif; other site 1302863000551 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1302863000552 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1302863000553 ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268 1302863000554 Walker A/P-loop; other site 1302863000555 ATP binding site [chemical binding]; other site 1302863000556 Q-loop/lid; other site 1302863000557 ABC transporter signature motif; other site 1302863000558 Walker B; other site 1302863000559 D-loop; other site 1302863000560 H-loop/switch region; other site 1302863000561 aminodeoxychorismate synthase; Provisional; Region: PRK07508 1302863000562 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 1302863000563 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 1302863000564 substrate-cofactor binding pocket; other site 1302863000565 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1302863000566 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302863000567 catalytic residue [active] 1302863000568 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1302863000569 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1302863000570 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1302863000571 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1302863000572 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1302863000573 ATP binding site [chemical binding]; other site 1302863000574 putative Mg++ binding site [ion binding]; other site 1302863000575 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1302863000576 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 1302863000577 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1302863000578 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1302863000579 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1302863000580 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1302863000581 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 1302863000582 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1302863000583 non-specific DNA binding site [nucleotide binding]; other site 1302863000584 salt bridge; other site 1302863000585 sequence-specific DNA binding site [nucleotide binding]; other site 1302863000586 Domain of unknown function (DUF955); Region: DUF955; pfam06114 1302863000587 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1302863000588 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1302863000589 THF binding site; other site 1302863000590 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1302863000591 substrate binding site [chemical binding]; other site 1302863000592 THF binding site; other site 1302863000593 zinc-binding site [ion binding]; other site 1302863000594 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1302863000595 FAD binding site [chemical binding]; other site 1302863000596 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 1302863000597 Predicted ATPase [General function prediction only]; Region: COG3899 1302863000598 AAA ATPase domain; Region: AAA_16; pfam13191 1302863000599 formimidoylglutamase; Provisional; Region: PRK13775 1302863000600 Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988 1302863000601 putative active site [active] 1302863000602 putative metal binding site [ion binding]; other site 1302863000603 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 1302863000604 active sites [active] 1302863000605 tetramer interface [polypeptide binding]; other site 1302863000606 amino acid transporter; Region: 2A0306; TIGR00909 1302863000607 HutD; Region: HutD; pfam05962 1302863000608 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1302863000609 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1302863000610 Potassium binding sites [ion binding]; other site 1302863000611 Cesium cation binding sites [ion binding]; other site 1302863000612 potential frameshift: common BLAST hit: gi|125717300|ref|YP_001034433.1| methenyltetrahydrofolate cyclohydrolase 1302863000613 Glutamate formiminotransferase [Amino acid transport and metabolism]; Region: COG3643 1302863000614 Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837 1302863000615 Formiminotransferase domain; Region: FTCD; pfam02971 1302863000616 urocanate hydratase; Provisional; Region: PRK05414 1302863000617 imidazolonepropionase; Validated; Region: PRK09356 1302863000618 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 1302863000619 active site 1302863000620 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1302863000621 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1302863000622 Ligand binding site; other site 1302863000623 Putative Catalytic site; other site 1302863000624 DXD motif; other site 1302863000625 GtrA-like protein; Region: GtrA; pfam04138 1302863000626 serine/threonine transporter SstT; Provisional; Region: PRK13628 1302863000627 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1302863000628 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1302863000629 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1302863000630 Predicted transcriptional regulator [Transcription]; Region: COG2378 1302863000631 HTH domain; Region: HTH_11; pfam08279 1302863000632 WYL domain; Region: WYL; pfam13280 1302863000633 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 1302863000634 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 1302863000635 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 1302863000636 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 1302863000637 GrpE; Region: GrpE; pfam01025 1302863000638 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1302863000639 dimer interface [polypeptide binding]; other site 1302863000640 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1302863000641 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1302863000642 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1302863000643 nucleotide binding site [chemical binding]; other site 1302863000644 NEF interaction site [polypeptide binding]; other site 1302863000645 SBD interface [polypeptide binding]; other site 1302863000646 chaperone protein DnaJ; Provisional; Region: PRK14276 1302863000647 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1302863000648 HSP70 interaction site [polypeptide binding]; other site 1302863000649 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1302863000650 substrate binding site [polypeptide binding]; other site 1302863000651 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1302863000652 Zn binding sites [ion binding]; other site 1302863000653 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1302863000654 dimer interface [polypeptide binding]; other site 1302863000655 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1302863000656 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1302863000657 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 1302863000658 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1302863000659 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1302863000660 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1302863000661 hypothetical protein; Provisional; Region: PRK13667 1302863000662 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1302863000663 Glycoprotease family; Region: Peptidase_M22; pfam00814 1302863000664 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1302863000665 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1302863000666 Coenzyme A binding pocket [chemical binding]; other site 1302863000667 UGMP family protein; Validated; Region: PRK09604 1302863000668 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 1302863000669 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 1302863000670 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1302863000671 Predicted membrane protein [Function unknown]; Region: COG4392 1302863000672 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1302863000673 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1302863000674 S-adenosylmethionine binding site [chemical binding]; other site 1302863000675 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 1302863000676 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1302863000677 DNA binding residues [nucleotide binding] 1302863000678 dimer interface [polypeptide binding]; other site 1302863000679 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 1302863000680 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1302863000681 putative active site [active] 1302863000682 nucleotide binding site [chemical binding]; other site 1302863000683 nudix motif; other site 1302863000684 putative metal binding site [ion binding]; other site 1302863000685 HI0933-like protein; Region: HI0933_like; pfam03486 1302863000686 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1302863000687 Chromate resistance exported protein; Region: Chrome_Resist; cl01744 1302863000688 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1302863000689 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1302863000690 active site 1302863000691 catalytic tetrad [active] 1302863000692 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1302863000693 16S/18S rRNA binding site [nucleotide binding]; other site 1302863000694 S13e-L30e interaction site [polypeptide binding]; other site 1302863000695 25S rRNA binding site [nucleotide binding]; other site 1302863000696 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1302863000697 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1302863000698 glutaminase active site [active] 1302863000699 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1302863000700 dimer interface [polypeptide binding]; other site 1302863000701 active site 1302863000702 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1302863000703 dimer interface [polypeptide binding]; other site 1302863000704 active site 1302863000705 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1302863000706 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1302863000707 Walker A motif; other site 1302863000708 ATP binding site [chemical binding]; other site 1302863000709 Walker B motif; other site 1302863000710 arginine finger; other site 1302863000711 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1302863000712 Walker A motif; other site 1302863000713 ATP binding site [chemical binding]; other site 1302863000714 Walker B motif; other site 1302863000715 arginine finger; other site 1302863000716 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1302863000717 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1302863000718 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1302863000719 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1302863000720 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1302863000721 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1302863000722 active site 1302863000723 metal binding site [ion binding]; metal-binding site 1302863000724 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 1302863000725 potential frameshift: common BLAST hit: gi|125718981|ref|YP_001036114.1| ATP-dependent Clp protease, ATP-binding subunit 1302863000726 putative acetyltransferase; Provisional; Region: PRK03624 1302863000727 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1302863000728 Coenzyme A binding pocket [chemical binding]; other site 1302863000729 Herpesvirus latent membrane protein 1 (LMP1); Region: Herpes_LMP1; pfam05297 1302863000730 nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526 1302863000731 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1302863000732 active site 1302863000733 nucleotide binding site [chemical binding]; other site 1302863000734 HIGH motif; other site 1302863000735 KMSKS motif; other site 1302863000736 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1302863000737 nicotinamide mononucleotide transporter PnuC; Region: NMN_trans_PnuC; TIGR01528 1302863000738 ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051 1302863000739 nudix motif; other site 1302863000740 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1302863000741 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1302863000742 FMN binding site [chemical binding]; other site 1302863000743 active site 1302863000744 catalytic residues [active] 1302863000745 substrate binding site [chemical binding]; other site 1302863000746 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1302863000747 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1302863000748 dimerization interface [polypeptide binding]; other site 1302863000749 domain crossover interface; other site 1302863000750 redox-dependent activation switch; other site 1302863000751 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1302863000752 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1302863000753 catalytic residues [active] 1302863000754 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 1302863000755 amphipathic channel; other site 1302863000756 Asn-Pro-Ala signature motifs; other site 1302863000757 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 1302863000758 oligoendopeptidase F; Region: pepF; TIGR00181 1302863000759 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1302863000760 Zn binding site [ion binding]; other site 1302863000761 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1302863000762 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1302863000763 RNase E interface [polypeptide binding]; other site 1302863000764 trimer interface [polypeptide binding]; other site 1302863000765 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1302863000766 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1302863000767 RNase E interface [polypeptide binding]; other site 1302863000768 trimer interface [polypeptide binding]; other site 1302863000769 active site 1302863000770 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1302863000771 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1302863000772 RNA binding site [nucleotide binding]; other site 1302863000773 domain interface; other site 1302863000774 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 1302863000775 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1302863000776 trimer interface [polypeptide binding]; other site 1302863000777 active site 1302863000778 substrate binding site [chemical binding]; other site 1302863000779 CoA binding site [chemical binding]; other site 1302863000780 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 1302863000781 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 1302863000782 NADP+ binding site [chemical binding]; other site 1302863000783 RibD C-terminal domain; Region: RibD_C; cl17279 1302863000784 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1302863000785 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1302863000786 active site 1302863000787 HIGH motif; other site 1302863000788 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1302863000789 KMSKS motif; other site 1302863000790 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1302863000791 tRNA binding surface [nucleotide binding]; other site 1302863000792 anticodon binding site; other site 1302863000793 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1302863000794 active site 1302863000795 metal binding site [ion binding]; metal-binding site 1302863000796 dimerization interface [polypeptide binding]; other site 1302863000797 Amino acid permease; Region: AA_permease_2; pfam13520 1302863000798 Predicted membrane protein [Function unknown]; Region: COG4129 1302863000799 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1302863000800 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 1302863000801 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 1302863000802 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1302863000803 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 1302863000804 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1302863000805 Walker A/P-loop; other site 1302863000806 ATP binding site [chemical binding]; other site 1302863000807 Q-loop/lid; other site 1302863000808 ABC transporter signature motif; other site 1302863000809 Walker B; other site 1302863000810 D-loop; other site 1302863000811 H-loop/switch region; other site 1302863000812 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 1302863000813 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1302863000814 potential frameshift: common BLAST hit: gi|387784384|ref|YP_006070467.1| ABC transporter permease 1302863000815 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1302863000816 Coenzyme A binding pocket [chemical binding]; other site 1302863000817 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1302863000818 Colicin V production protein; Region: Colicin_V; pfam02674 1302863000819 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 1302863000820 MutS domain III; Region: MutS_III; pfam05192 1302863000821 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 1302863000822 Walker A/P-loop; other site 1302863000823 ATP binding site [chemical binding]; other site 1302863000824 Q-loop/lid; other site 1302863000825 ABC transporter signature motif; other site 1302863000826 Walker B; other site 1302863000827 D-loop; other site 1302863000828 H-loop/switch region; other site 1302863000829 Smr domain; Region: Smr; pfam01713 1302863000830 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1302863000831 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1302863000832 catalytic residues [active] 1302863000833 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1302863000834 HIT family signature motif; other site 1302863000835 catalytic residue [active] 1302863000836 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1302863000837 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1302863000838 Walker A/P-loop; other site 1302863000839 ATP binding site [chemical binding]; other site 1302863000840 Q-loop/lid; other site 1302863000841 ABC transporter signature motif; other site 1302863000842 Walker B; other site 1302863000843 D-loop; other site 1302863000844 H-loop/switch region; other site 1302863000845 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 1302863000846 Thiamine kinase and related kinases [Coenzyme transport and metabolism]; Region: ycfN; COG0510 1302863000847 Phosphotransferase enzyme family; Region: APH; pfam01636 1302863000848 substrate binding site [chemical binding]; other site 1302863000849 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1302863000850 S-adenosylmethionine binding site [chemical binding]; other site 1302863000851 legume lectins; Region: lectin_L-type; cd01951 1302863000852 homotetramer interaction site [polypeptide binding]; other site 1302863000853 carbohydrate binding site [chemical binding]; other site 1302863000854 metal binding site [ion binding]; metal-binding site 1302863000855 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 1302863000856 MucBP domain; Region: MucBP; pfam06458 1302863000857 MucBP domain; Region: MucBP; pfam06458 1302863000858 MucBP domain; Region: MucBP; pfam06458 1302863000859 MucBP domain; Region: MucBP; pfam06458 1302863000860 MucBP domain; Region: MucBP; pfam06458 1302863000861 MucBP domain; Region: MucBP; pfam06458 1302863000862 MucBP domain; Region: MucBP; pfam06458 1302863000863 hypothetical protein; Provisional; Region: PRK12378 1302863000864 epoxyqueuosine reductase; Region: TIGR00276 1302863000865 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1302863000866 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1302863000867 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1302863000868 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1302863000869 nucleotide binding region [chemical binding]; other site 1302863000870 ATP-binding site [chemical binding]; other site 1302863000871 SEC-C motif; Region: SEC-C; pfam02810 1302863000872 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; cl17260 1302863000873 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1302863000874 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; cl17260 1302863000875 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1302863000876 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1302863000877 alanine racemase; Reviewed; Region: alr; PRK00053 1302863000878 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1302863000879 active site 1302863000880 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1302863000881 dimer interface [polypeptide binding]; other site 1302863000882 substrate binding site [chemical binding]; other site 1302863000883 catalytic residues [active] 1302863000884 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1302863000885 Y-family of DNA polymerases; Region: PolY; cl12025 1302863000886 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1302863000887 ssDNA binding site; other site 1302863000888 generic binding surface II; other site 1302863000889 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1302863000890 ATP binding site [chemical binding]; other site 1302863000891 putative Mg++ binding site [ion binding]; other site 1302863000892 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1302863000893 nucleotide binding region [chemical binding]; other site 1302863000894 ATP-binding site [chemical binding]; other site 1302863000895 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1302863000896 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1302863000897 active site 1302863000898 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 1302863000899 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1302863000900 homodimer interface [polypeptide binding]; other site 1302863000901 NAD binding pocket [chemical binding]; other site 1302863000902 ATP binding pocket [chemical binding]; other site 1302863000903 Mg binding site [ion binding]; other site 1302863000904 active-site loop [active] 1302863000905 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 1302863000906 trimer interface [polypeptide binding]; other site 1302863000907 active site 1302863000908 G bulge; other site 1302863000909 Integrase core domain; Region: rve_2; pfam13333 1302863000910 Integrase core domain; Region: rve; pfam00665 1302863000911 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1302863000912 Homeodomain-like domain; Region: HTH_23; cl17451 1302863000913 Transposase; Region: HTH_Tnp_1; cl17663 1302863000914 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1302863000915 DNA binding site [nucleotide binding] 1302863000916 active site 1302863000917 Int/Topo IB signature motif; other site 1302863000918 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1302863000919 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1302863000920 DHH family; Region: DHH; pfam01368 1302863000921 DHHA1 domain; Region: DHHA1; pfam02272 1302863000922 flavodoxin; Validated; Region: PRK07308 1302863000923 Chorismate mutase type II; Region: CM_2; cl00693 1302863000924 Chorismate mutase type II; Region: CM_2; cl00693 1302863000925 camphor resistance protein CrcB; Provisional; Region: PRK14221 1302863000926 camphor resistance protein CrcB; Provisional; Region: PRK14229 1302863000927 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1302863000928 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1302863000929 CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203 1302863000930 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1302863000931 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09651 1302863000932 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 1302863000933 potential frameshift: common BLAST hit: gi|387785562|ref|YP_006250658.1| CRISPR-associated protein csd1 1302863000934 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465 1302863000935 CRISPR-associated protein Cas4 (RecB family exonuclease) [Defense mechanisms]; Region: COG1468 1302863000936 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 1302863000937 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 1302863000938 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302863000939 dimer interface [polypeptide binding]; other site 1302863000940 conserved gate region; other site 1302863000941 putative PBP binding loops; other site 1302863000942 ABC-ATPase subunit interface; other site 1302863000943 potential frameshift: common BLAST hit: gi|289168137|ref|YP_003446406.1| amino acid ABC transporter ATP-binding protein 1302863000944 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1302863000945 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1302863000946 substrate binding pocket [chemical binding]; other site 1302863000947 membrane-bound complex binding site; other site 1302863000948 hinge residues; other site 1302863000949 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1302863000950 Cation efflux family; Region: Cation_efflux; pfam01545 1302863000951 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1302863000952 Part of AAA domain; Region: AAA_19; pfam13245 1302863000953 Family description; Region: UvrD_C_2; pfam13538 1302863000954 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 1302863000955 nudix motif; other site 1302863000956 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 1302863000957 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1302863000958 homodimer interface [polypeptide binding]; other site 1302863000959 substrate-cofactor binding pocket; other site 1302863000960 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302863000961 catalytic residue [active] 1302863000962 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1302863000963 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1302863000964 Ligand binding site; other site 1302863000965 Putative Catalytic site; other site 1302863000966 DXD motif; other site 1302863000967 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 1302863000968 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 1302863000969 NADP binding site [chemical binding]; other site 1302863000970 active site 1302863000971 putative substrate binding site [chemical binding]; other site 1302863000972 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1302863000973 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1302863000974 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1302863000975 active site 1302863000976 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1302863000977 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1302863000978 active site 1302863000979 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 1302863000980 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1302863000981 Ligand binding site; other site 1302863000982 Putative Catalytic site; other site 1302863000983 DXD motif; other site 1302863000984 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1302863000985 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1302863000986 active site 1302863000987 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1302863000988 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1302863000989 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1302863000990 active site 1302863000991 Rhamnan synthesis protein F; Region: RgpF; pfam05045 1302863000992 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1302863000993 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1302863000994 Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913 1302863000995 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1302863000996 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1302863000997 potential frameshift: common BLAST hit: gi|125718321|ref|YP_001035454.1| rhamnosyltransferase 1302863000998 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1302863000999 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196 1302863001000 Probable Catalytic site; other site 1302863001001 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1302863001002 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1302863001003 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 1302863001004 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1302863001005 Walker A/P-loop; other site 1302863001006 ATP binding site [chemical binding]; other site 1302863001007 Q-loop/lid; other site 1302863001008 ABC transporter signature motif; other site 1302863001009 Walker B; other site 1302863001010 D-loop; other site 1302863001011 H-loop/switch region; other site 1302863001012 Rhamnan synthesis protein F; Region: RgpF; pfam05045 1302863001013 Sulfatase; Region: Sulfatase; pfam00884 1302863001014 potential frameshift: common BLAST hit: gi|337281790|ref|YP_004621261.1| pore forming protein 1302863001015 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 1302863001016 cytidylate kinase; Provisional; Region: cmk; PRK00023 1302863001017 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1302863001018 CMP-binding site; other site 1302863001019 The sites determining sugar specificity; other site 1302863001020 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1302863001021 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1302863001022 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1302863001023 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1302863001024 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1302863001025 23S rRNA binding site [nucleotide binding]; other site 1302863001026 L21 binding site [polypeptide binding]; other site 1302863001027 L13 binding site [polypeptide binding]; other site 1302863001028 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 1302863001029 catalytic motif [active] 1302863001030 Zn binding site [ion binding]; other site 1302863001031 Tetratricopeptide repeat; Region: TPR_12; pfam13424 1302863001032 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1302863001033 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1302863001034 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1302863001035 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1302863001036 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1302863001037 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1302863001038 hinge; other site 1302863001039 active site 1302863001040 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1302863001041 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1302863001042 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 1302863001043 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1302863001044 DNA-binding site [nucleotide binding]; DNA binding site 1302863001045 DRTGG domain; Region: DRTGG; pfam07085 1302863001046 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 1302863001047 active site 2 [active] 1302863001048 active site 1 [active] 1302863001049 Thioesterase superfamily; Region: 4HBT; pfam03061 1302863001050 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1302863001051 active site 1302863001052 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 1302863001053 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1302863001054 MarR family; Region: MarR_2; pfam12802 1302863001055 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 1302863001056 B3/4 domain; Region: B3_4; pfam03483 1302863001057 Predicted membrane protein [Function unknown]; Region: COG2246 1302863001058 GtrA-like protein; Region: GtrA; pfam04138 1302863001059 Predicted membrane protein [Function unknown]; Region: COG4708 1302863001060 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1302863001061 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1302863001062 nucleotide binding pocket [chemical binding]; other site 1302863001063 K-X-D-G motif; other site 1302863001064 catalytic site [active] 1302863001065 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1302863001066 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1302863001067 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1302863001068 Dimer interface [polypeptide binding]; other site 1302863001069 BRCT sequence motif; other site 1302863001070 putative lipid kinase; Reviewed; Region: PRK13055 1302863001071 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1302863001072 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 1302863001073 carbohydrate binding site [chemical binding]; other site 1302863001074 pullulanase, type I; Region: pulA_typeI; TIGR02104 1302863001075 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1302863001076 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 1302863001077 Ca binding site [ion binding]; other site 1302863001078 active site 1302863001079 catalytic site [active] 1302863001080 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1302863001081 Sulfatase; Region: Sulfatase; pfam00884 1302863001082 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 1302863001083 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1302863001084 putative RNA binding site [nucleotide binding]; other site 1302863001085 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1302863001086 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1302863001087 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1302863001088 active site 1302863001089 catalytic residue [active] 1302863001090 dimer interface [polypeptide binding]; other site 1302863001091 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1302863001092 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1302863001093 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1302863001094 shikimate binding site; other site 1302863001095 NAD(P) binding site [chemical binding]; other site 1302863001096 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1302863001097 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 1302863001098 active site 1302863001099 dimer interface [polypeptide binding]; other site 1302863001100 metal binding site [ion binding]; metal-binding site 1302863001101 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1302863001102 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1302863001103 Tetramer interface [polypeptide binding]; other site 1302863001104 active site 1302863001105 FMN-binding site [chemical binding]; other site 1302863001106 prephenate dehydrogenase; Validated; Region: PRK06545 1302863001107 prephenate dehydrogenase; Validated; Region: PRK08507 1302863001108 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 1302863001109 hypothetical protein; Provisional; Region: PRK13676 1302863001110 Thioesterase-like superfamily; Region: 4HBT_2; pfam13279 1302863001111 Family of unknown function (DUF695); Region: DUF695; pfam05117 1302863001112 Protein of unknown function (DUF1260); Region: DUF1260; pfam06877 1302863001113 potential protein location (hypothetical protein I872_02095 [Streptococcus oligofermentans AS 1.3089]) that overlaps RNA (tRNA-S) 1302863001114 LrgA family; Region: LrgA; pfam03788 1302863001115 LrgB-like family; Region: LrgB; pfam04172 1302863001116 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1302863001117 Predicted flavoprotein [General function prediction only]; Region: COG0431 1302863001118 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1302863001119 MarR family; Region: MarR; pfam01047 1302863001120 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 1302863001121 aspartate aminotransferase; Provisional; Region: PRK05764 1302863001122 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1302863001123 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302863001124 homodimer interface [polypeptide binding]; other site 1302863001125 catalytic residue [active] 1302863001126 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 1302863001127 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1302863001128 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1302863001129 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 1302863001130 putative dimer interface [polypeptide binding]; other site 1302863001131 putative anticodon binding site; other site 1302863001132 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1302863001133 homodimer interface [polypeptide binding]; other site 1302863001134 motif 1; other site 1302863001135 motif 2; other site 1302863001136 active site 1302863001137 motif 3; other site 1302863001138 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302863001139 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1302863001140 putative substrate translocation pore; other site 1302863001141 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1302863001142 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1302863001143 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1302863001144 Walker A/P-loop; other site 1302863001145 ATP binding site [chemical binding]; other site 1302863001146 Q-loop/lid; other site 1302863001147 ABC transporter signature motif; other site 1302863001148 Walker B; other site 1302863001149 D-loop; other site 1302863001150 H-loop/switch region; other site 1302863001151 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1302863001152 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1302863001153 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1302863001154 Walker A/P-loop; other site 1302863001155 ATP binding site [chemical binding]; other site 1302863001156 Q-loop/lid; other site 1302863001157 ABC transporter signature motif; other site 1302863001158 Walker B; other site 1302863001159 D-loop; other site 1302863001160 H-loop/switch region; other site 1302863001161 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1302863001162 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1302863001163 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1302863001164 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1302863001165 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1302863001166 Walker A/P-loop; other site 1302863001167 ATP binding site [chemical binding]; other site 1302863001168 Q-loop/lid; other site 1302863001169 ABC transporter signature motif; other site 1302863001170 Walker B; other site 1302863001171 D-loop; other site 1302863001172 H-loop/switch region; other site 1302863001173 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1302863001174 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1302863001175 substrate binding pocket [chemical binding]; other site 1302863001176 membrane-bound complex binding site; other site 1302863001177 hinge residues; other site 1302863001178 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1302863001179 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1302863001180 substrate binding pocket [chemical binding]; other site 1302863001181 membrane-bound complex binding site; other site 1302863001182 hinge residues; other site 1302863001183 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1302863001184 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302863001185 dimer interface [polypeptide binding]; other site 1302863001186 conserved gate region; other site 1302863001187 putative PBP binding loops; other site 1302863001188 ABC-ATPase subunit interface; other site 1302863001189 CAAX protease self-immunity; Region: Abi; pfam02517 1302863001190 excinuclease ABC subunit B; Provisional; Region: PRK05298 1302863001191 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1302863001192 ATP binding site [chemical binding]; other site 1302863001193 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1302863001194 nucleotide binding region [chemical binding]; other site 1302863001195 ATP-binding site [chemical binding]; other site 1302863001196 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1302863001197 UvrB/uvrC motif; Region: UVR; pfam02151 1302863001198 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 1302863001199 Protein of unknown function (DUF1697); Region: DUF1697; pfam08002 1302863001200 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1302863001201 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1302863001202 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1302863001203 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1302863001204 recombination protein RecR; Reviewed; Region: recR; PRK00076 1302863001205 RecR protein; Region: RecR; pfam02132 1302863001206 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1302863001207 putative active site [active] 1302863001208 putative metal-binding site [ion binding]; other site 1302863001209 tetramer interface [polypeptide binding]; other site 1302863001210 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1302863001211 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1302863001212 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1302863001213 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1302863001214 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1302863001215 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1302863001216 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 1302863001217 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 1302863001218 nudix motif; other site 1302863001219 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 1302863001220 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 1302863001221 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1302863001222 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1302863001223 G1 box; other site 1302863001224 putative GEF interaction site [polypeptide binding]; other site 1302863001225 GTP/Mg2+ binding site [chemical binding]; other site 1302863001226 Switch I region; other site 1302863001227 G2 box; other site 1302863001228 G3 box; other site 1302863001229 Switch II region; other site 1302863001230 G4 box; other site 1302863001231 G5 box; other site 1302863001232 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1302863001233 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 1302863001234 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1302863001235 Cl binding site [ion binding]; other site 1302863001236 oligomer interface [polypeptide binding]; other site 1302863001237 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 1302863001238 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1302863001239 Walker A/P-loop; other site 1302863001240 ATP binding site [chemical binding]; other site 1302863001241 Q-loop/lid; other site 1302863001242 ABC transporter signature motif; other site 1302863001243 Walker B; other site 1302863001244 D-loop; other site 1302863001245 H-loop/switch region; other site 1302863001246 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1302863001247 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1302863001248 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1302863001249 putative nucleotide binding site [chemical binding]; other site 1302863001250 uridine monophosphate binding site [chemical binding]; other site 1302863001251 homohexameric interface [polypeptide binding]; other site 1302863001252 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1302863001253 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1302863001254 hinge region; other site 1302863001255 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 1302863001256 S1 domain; Region: S1_2; pfam13509 1302863001257 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 1302863001258 potential frameshift: common BLAST hit: gi|24379344|ref|NP_721299.1| type I restriction-modification system DNA methylase 1302863001259 Virulence protein [General function prediction only]; Region: COG3943 1302863001260 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 1302863001261 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1302863001262 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1302863001263 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1302863001264 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1302863001265 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1302863001266 AAA domain; Region: AAA_13; pfam13166 1302863001267 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1302863001268 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1302863001269 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1302863001270 ATP binding site [chemical binding]; other site 1302863001271 putative Mg++ binding site [ion binding]; other site 1302863001272 hypothetical protein; Provisional; Region: PRK13672 1302863001273 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1302863001274 PhoH-like protein; Region: PhoH; pfam02562 1302863001275 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1302863001276 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1302863001277 dimer interface [polypeptide binding]; other site 1302863001278 putative radical transfer pathway; other site 1302863001279 diiron center [ion binding]; other site 1302863001280 tyrosyl radical; other site 1302863001281 Protein of unknown function (DUF4238); Region: DUF4238; pfam14022 1302863001282 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 1302863001283 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1302863001284 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1302863001285 active site 1302863001286 dimer interface [polypeptide binding]; other site 1302863001287 catalytic residues [active] 1302863001288 effector binding site; other site 1302863001289 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1302863001290 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1302863001291 catalytic residues [active] 1302863001292 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1302863001293 dimerization domain swap beta strand [polypeptide binding]; other site 1302863001294 regulatory protein interface [polypeptide binding]; other site 1302863001295 active site 1302863001296 regulatory phosphorylation site [posttranslational modification]; other site 1302863001297 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1302863001298 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1302863001299 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1302863001300 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1302863001301 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1302863001302 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1302863001303 NAD(P) binding site [chemical binding]; other site 1302863001304 catalytic residues [active] 1302863001305 glycogen branching enzyme; Provisional; Region: PRK12313 1302863001306 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1302863001307 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1302863001308 active site 1302863001309 catalytic site [active] 1302863001310 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1302863001311 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 1302863001312 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1302863001313 ligand binding site; other site 1302863001314 oligomer interface; other site 1302863001315 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1302863001316 dimer interface [polypeptide binding]; other site 1302863001317 N-terminal domain interface [polypeptide binding]; other site 1302863001318 sulfate 1 binding site; other site 1302863001319 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 1302863001320 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1302863001321 active site 1302863001322 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1302863001323 dimer interface [polypeptide binding]; other site 1302863001324 N-terminal domain interface [polypeptide binding]; other site 1302863001325 sulfate 1 binding site; other site 1302863001326 glycogen synthase; Provisional; Region: glgA; PRK00654 1302863001327 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1302863001328 ADP-binding pocket [chemical binding]; other site 1302863001329 homodimer interface [polypeptide binding]; other site 1302863001330 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1302863001331 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1302863001332 active site 1302863001333 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1302863001334 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1302863001335 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1302863001336 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1302863001337 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1302863001338 binding surface 1302863001339 TPR motif; other site 1302863001340 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1302863001341 binding surface 1302863001342 TPR motif; other site 1302863001343 Domain of unknown function (DUF4298); Region: DUF4298; pfam14131 1302863001344 hypothetical protein; Provisional; Region: PRK07329 1302863001345 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1302863001346 active site 1302863001347 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 1302863001348 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 1302863001349 Domain of unknown function (DUF814); Region: DUF814; pfam05670 1302863001350 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 1302863001351 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1302863001352 zinc binding site [ion binding]; other site 1302863001353 putative ligand binding site [chemical binding]; other site 1302863001354 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1302863001355 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1302863001356 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1302863001357 dimer interface [polypeptide binding]; other site 1302863001358 motif 1; other site 1302863001359 active site 1302863001360 motif 2; other site 1302863001361 motif 3; other site 1302863001362 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1302863001363 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1302863001364 Coenzyme A binding pocket [chemical binding]; other site 1302863001365 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1302863001366 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1302863001367 putative tRNA-binding site [nucleotide binding]; other site 1302863001368 B3/4 domain; Region: B3_4; pfam03483 1302863001369 tRNA synthetase B5 domain; Region: B5; smart00874 1302863001370 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1302863001371 dimer interface [polypeptide binding]; other site 1302863001372 motif 1; other site 1302863001373 motif 3; other site 1302863001374 motif 2; other site 1302863001375 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1302863001376 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 1302863001377 Bacterial lipoprotein; Region: DUF3642; pfam12182 1302863001378 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1302863001379 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1302863001380 FtsX-like permease family; Region: FtsX; pfam02687 1302863001381 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1302863001382 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1302863001383 Walker A/P-loop; other site 1302863001384 ATP binding site [chemical binding]; other site 1302863001385 Q-loop/lid; other site 1302863001386 ABC transporter signature motif; other site 1302863001387 Walker B; other site 1302863001388 D-loop; other site 1302863001389 H-loop/switch region; other site 1302863001390 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1302863001391 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1302863001392 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1302863001393 G1 box; other site 1302863001394 GTP/Mg2+ binding site [chemical binding]; other site 1302863001395 Switch I region; other site 1302863001396 G2 box; other site 1302863001397 Switch II region; other site 1302863001398 G3 box; other site 1302863001399 G4 box; other site 1302863001400 G5 box; other site 1302863001401 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1302863001402 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1302863001403 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1302863001404 active site 1302863001405 dimer interface [polypeptide binding]; other site 1302863001406 phosphopentomutase; Provisional; Region: PRK05362 1302863001407 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1302863001408 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1302863001409 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1302863001410 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 1302863001411 Cl- selectivity filter; other site 1302863001412 Cl- binding residues [ion binding]; other site 1302863001413 pore gating glutamate residue; other site 1302863001414 dimer interface [polypeptide binding]; other site 1302863001415 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1302863001416 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl09873 1302863001417 NAD-dependent deacetylase; Provisional; Region: PRK00481 1302863001418 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 1302863001419 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 1302863001420 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 1302863001421 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652 1302863001422 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680 1302863001423 CRISPR-associated protein Cas10/Csm1, subtype III-A/MTUBE; Region: cas_TM1811_Csm1; TIGR02578 1302863001424 CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cl00622 1302863001425 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214 1302863001426 CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cl17438 1302863001427 CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cl17437 1302863001428 CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl09873 1302863001429 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1302863001430 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1302863001431 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1302863001432 dimerization interface [polypeptide binding]; other site 1302863001433 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 1302863001434 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 1302863001435 FAD binding pocket [chemical binding]; other site 1302863001436 FAD binding motif [chemical binding]; other site 1302863001437 phosphate binding motif [ion binding]; other site 1302863001438 beta-alpha-beta structure motif; other site 1302863001439 NAD binding pocket [chemical binding]; other site 1302863001440 Iron coordination center [ion binding]; other site 1302863001441 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1302863001442 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 1302863001443 heterodimer interface [polypeptide binding]; other site 1302863001444 active site 1302863001445 FMN binding site [chemical binding]; other site 1302863001446 homodimer interface [polypeptide binding]; other site 1302863001447 substrate binding site [chemical binding]; other site 1302863001448 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1302863001449 active site 1302863001450 dimer interface [polypeptide binding]; other site 1302863001451 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1302863001452 active site 1302863001453 conserved hypothetical integral membrane protein; Region: TIGR03766 1302863001454 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1302863001455 ligand binding site [chemical binding]; other site 1302863001456 active site 1302863001457 UGI interface [polypeptide binding]; other site 1302863001458 catalytic site [active] 1302863001459 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1302863001460 putative active site [active] 1302863001461 nucleotide binding site [chemical binding]; other site 1302863001462 nudix motif; other site 1302863001463 putative metal binding site [ion binding]; other site 1302863001464 dihydroorotase; Validated; Region: pyrC; PRK09357 1302863001465 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1302863001466 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 1302863001467 active site 1302863001468 NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530 1302863001469 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408 1302863001470 putative active site [active] 1302863001471 putative metal binding site [ion binding]; other site 1302863001472 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1302863001473 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1302863001474 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 1302863001475 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302863001476 Mg2+ binding site [ion binding]; other site 1302863001477 G-X-G motif; other site 1302863001478 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1302863001479 anchoring element; other site 1302863001480 dimer interface [polypeptide binding]; other site 1302863001481 ATP binding site [chemical binding]; other site 1302863001482 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1302863001483 active site 1302863001484 putative metal-binding site [ion binding]; other site 1302863001485 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1302863001486 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 1302863001487 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 1302863001488 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1302863001489 CAP-like domain; other site 1302863001490 active site 1302863001491 primary dimer interface [polypeptide binding]; other site 1302863001492 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1302863001493 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 1302863001494 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1302863001495 homodimer interface [polypeptide binding]; other site 1302863001496 substrate-cofactor binding pocket; other site 1302863001497 catalytic residue [active] 1302863001498 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 1302863001499 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 1302863001500 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1302863001501 RNA binding site [nucleotide binding]; other site 1302863001502 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1302863001503 RNA binding site [nucleotide binding]; other site 1302863001504 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1302863001505 RNA binding site [nucleotide binding]; other site 1302863001506 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 1302863001507 RNA binding site [nucleotide binding]; other site 1302863001508 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 1302863001509 active site 1302863001510 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1302863001511 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1302863001512 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1302863001513 Walker A/P-loop; other site 1302863001514 ATP binding site [chemical binding]; other site 1302863001515 Q-loop/lid; other site 1302863001516 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1302863001517 ABC transporter signature motif; other site 1302863001518 Walker B; other site 1302863001519 D-loop; other site 1302863001520 ABC transporter; Region: ABC_tran_2; pfam12848 1302863001521 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1302863001522 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 1302863001523 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1302863001524 non-specific DNA binding site [nucleotide binding]; other site 1302863001525 salt bridge; other site 1302863001526 sequence-specific DNA binding site [nucleotide binding]; other site 1302863001527 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 1302863001528 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302863001529 putative substrate translocation pore; other site 1302863001530 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1302863001531 CoenzymeA binding site [chemical binding]; other site 1302863001532 subunit interaction site [polypeptide binding]; other site 1302863001533 PHB binding site; other site 1302863001534 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1302863001535 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1302863001536 motif II; other site 1302863001537 triosephosphate isomerase; Provisional; Region: PRK14567 1302863001538 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1302863001539 substrate binding site [chemical binding]; other site 1302863001540 dimer interface [polypeptide binding]; other site 1302863001541 catalytic triad [active] 1302863001542 potential frameshift: common BLAST hit: gi|125717703|ref|YP_001034836.1| N-acetylmuramidase/lysin 1302863001543 potential frameshift: common BLAST hit: gi|157151602|ref|YP_001451262.1| putative N-acetylmuramidase/lysin 1302863001544 FemAB family; Region: FemAB; pfam02388 1302863001545 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1302863001546 FemAB family; Region: FemAB; pfam02388 1302863001547 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 1302863001548 sugar phosphate phosphatase; Provisional; Region: PRK10513 1302863001549 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1302863001550 active site 1302863001551 motif I; other site 1302863001552 motif II; other site 1302863001553 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1302863001554 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 1302863001555 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1302863001556 Zn2+ binding site [ion binding]; other site 1302863001557 Mg2+ binding site [ion binding]; other site 1302863001558 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 1302863001559 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 1302863001560 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 1302863001561 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1302863001562 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1302863001563 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 1302863001564 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1302863001565 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1302863001566 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1302863001567 RF-1 domain; Region: RF-1; pfam00472 1302863001568 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 1302863001569 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1302863001570 Walker A/P-loop; other site 1302863001571 ATP binding site [chemical binding]; other site 1302863001572 Q-loop/lid; other site 1302863001573 ABC transporter signature motif; other site 1302863001574 Walker B; other site 1302863001575 D-loop; other site 1302863001576 H-loop/switch region; other site 1302863001577 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 1302863001578 FtsX-like permease family; Region: FtsX; pfam02687 1302863001579 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1302863001580 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK07246 1302863001581 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1302863001582 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1302863001583 ATP binding site [chemical binding]; other site 1302863001584 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1302863001585 Predicted membrane protein [Function unknown]; Region: COG2855 1302863001586 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1302863001587 DJ-1 family protein; Region: not_thiJ; TIGR01383 1302863001588 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1302863001589 conserved cys residue [active] 1302863001590 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1302863001591 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1302863001592 motif II; other site 1302863001593 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 1302863001594 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302863001595 Mg2+ binding site [ion binding]; other site 1302863001596 G-X-G motif; other site 1302863001597 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1302863001598 anchoring element; other site 1302863001599 dimer interface [polypeptide binding]; other site 1302863001600 ATP binding site [chemical binding]; other site 1302863001601 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1302863001602 active site 1302863001603 putative metal-binding site [ion binding]; other site 1302863001604 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1302863001605 septation ring formation regulator EzrA; Provisional; Region: PRK04778 1302863001606 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1302863001607 phosphoserine phosphatase SerB; Region: serB; TIGR00338 1302863001608 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1302863001609 motif II; other site 1302863001610 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1302863001611 Protein of unknown function (DUF1694); Region: DUF1694; pfam07997 1302863001612 enolase; Provisional; Region: eno; PRK00077 1302863001613 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1302863001614 dimer interface [polypeptide binding]; other site 1302863001615 metal binding site [ion binding]; metal-binding site 1302863001616 substrate binding pocket [chemical binding]; other site 1302863001617 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1302863001618 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1302863001619 Int/Topo IB signature motif; other site 1302863001620 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1302863001621 non-specific DNA binding site [nucleotide binding]; other site 1302863001622 salt bridge; other site 1302863001623 sequence-specific DNA binding site [nucleotide binding]; other site 1302863001624 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; cl09889 1302863001625 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 1302863001626 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1302863001627 Walker A motif; other site 1302863001628 ATP binding site [chemical binding]; other site 1302863001629 Walker B motif; other site 1302863001630 Immunoglobulin domain; Region: Ig; cl11960 1302863001631 Phage-related protein [Function unknown]; Region: COG4679 1302863001632 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1302863001633 non-specific DNA binding site [nucleotide binding]; other site 1302863001634 salt bridge; other site 1302863001635 sequence-specific DNA binding site [nucleotide binding]; other site 1302863001636 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1302863001637 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 1302863001638 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1302863001639 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1302863001640 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1302863001641 Walker A/P-loop; other site 1302863001642 ATP binding site [chemical binding]; other site 1302863001643 Q-loop/lid; other site 1302863001644 ABC transporter signature motif; other site 1302863001645 Walker B; other site 1302863001646 D-loop; other site 1302863001647 H-loop/switch region; other site 1302863001648 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1302863001649 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1302863001650 FtsX-like permease family; Region: FtsX; pfam02687 1302863001651 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1302863001652 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302863001653 active site 1302863001654 phosphorylation site [posttranslational modification] 1302863001655 intermolecular recognition site; other site 1302863001656 dimerization interface [polypeptide binding]; other site 1302863001657 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1302863001658 DNA binding site [nucleotide binding] 1302863001659 HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304 1302863001660 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1302863001661 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1302863001662 dimer interface [polypeptide binding]; other site 1302863001663 phosphorylation site [posttranslational modification] 1302863001664 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302863001665 ATP binding site [chemical binding]; other site 1302863001666 Mg2+ binding site [ion binding]; other site 1302863001667 G-X-G motif; other site 1302863001668 F0F1 ATP synthase subunit C; Provisional; Region: PRK13467 1302863001669 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1302863001670 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1302863001671 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1302863001672 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1302863001673 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1302863001674 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1302863001675 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1302863001676 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1302863001677 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1302863001678 beta subunit interaction interface [polypeptide binding]; other site 1302863001679 Walker A motif; other site 1302863001680 ATP binding site [chemical binding]; other site 1302863001681 Walker B motif; other site 1302863001682 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1302863001683 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1302863001684 core domain interface [polypeptide binding]; other site 1302863001685 delta subunit interface [polypeptide binding]; other site 1302863001686 epsilon subunit interface [polypeptide binding]; other site 1302863001687 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1302863001688 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1302863001689 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1302863001690 alpha subunit interaction interface [polypeptide binding]; other site 1302863001691 Walker A motif; other site 1302863001692 ATP binding site [chemical binding]; other site 1302863001693 Walker B motif; other site 1302863001694 inhibitor binding site; inhibition site 1302863001695 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1302863001696 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1302863001697 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1302863001698 gamma subunit interface [polypeptide binding]; other site 1302863001699 epsilon subunit interface [polypeptide binding]; other site 1302863001700 LBP interface [polypeptide binding]; other site 1302863001701 Protein of unknown function (DUF1146); Region: DUF1146; cl11486 1302863001702 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1302863001703 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1302863001704 hinge; other site 1302863001705 active site 1302863001706 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 1302863001707 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 1302863001708 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; pfam01223 1302863001709 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 1302863001710 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1302863001711 nucleotide binding site [chemical binding]; other site 1302863001712 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1302863001713 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1302863001714 dimerization interface [polypeptide binding]; other site 1302863001715 active site 1302863001716 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1302863001717 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1302863001718 folate binding site [chemical binding]; other site 1302863001719 NADP+ binding site [chemical binding]; other site 1302863001720 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1302863001721 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1302863001722 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1302863001723 Walker A motif; other site 1302863001724 ATP binding site [chemical binding]; other site 1302863001725 Walker B motif; other site 1302863001726 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1302863001727 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1302863001728 G1 box; other site 1302863001729 GTP/Mg2+ binding site [chemical binding]; other site 1302863001730 Switch I region; other site 1302863001731 G2 box; other site 1302863001732 G3 box; other site 1302863001733 Switch II region; other site 1302863001734 G4 box; other site 1302863001735 G5 box; other site 1302863001736 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1302863001737 homocysteine methyltransferase; Provisional; Region: mmuM; PRK09485 1302863001738 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1302863001739 Formate/nitrite transporter; Region: Form_Nir_trans; cl00927 1302863001740 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 1302863001741 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1302863001742 23S rRNA interface [nucleotide binding]; other site 1302863001743 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1302863001744 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1302863001745 core dimer interface [polypeptide binding]; other site 1302863001746 L10 interface [polypeptide binding]; other site 1302863001747 L11 interface [polypeptide binding]; other site 1302863001748 putative EF-Tu interaction site [polypeptide binding]; other site 1302863001749 putative EF-G interaction site [polypeptide binding]; other site 1302863001750 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1302863001751 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1302863001752 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1302863001753 Walker A/P-loop; other site 1302863001754 ATP binding site [chemical binding]; other site 1302863001755 Q-loop/lid; other site 1302863001756 ABC transporter signature motif; other site 1302863001757 Walker B; other site 1302863001758 D-loop; other site 1302863001759 H-loop/switch region; other site 1302863001760 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1302863001761 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1302863001762 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1302863001763 Walker A/P-loop; other site 1302863001764 ATP binding site [chemical binding]; other site 1302863001765 Q-loop/lid; other site 1302863001766 ABC transporter signature motif; other site 1302863001767 Walker B; other site 1302863001768 D-loop; other site 1302863001769 H-loop/switch region; other site 1302863001770 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 1302863001771 B3/4 domain; Region: B3_4; pfam03483 1302863001772 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1302863001773 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1302863001774 putative active site [active] 1302863001775 Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547 1302863001776 potential frameshift: common BLAST hit: gi|157150937|ref|YP_001450469.1| LPXTG cell wall surface protein 1302863001777 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1302863001778 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302863001779 active site 1302863001780 phosphorylation site [posttranslational modification] 1302863001781 intermolecular recognition site; other site 1302863001782 dimerization interface [polypeptide binding]; other site 1302863001783 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1302863001784 DNA binding site [nucleotide binding] 1302863001785 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1302863001786 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1302863001787 dimerization interface [polypeptide binding]; other site 1302863001788 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1302863001789 dimer interface [polypeptide binding]; other site 1302863001790 phosphorylation site [posttranslational modification] 1302863001791 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302863001792 ATP binding site [chemical binding]; other site 1302863001793 Mg2+ binding site [ion binding]; other site 1302863001794 G-X-G motif; other site 1302863001795 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1302863001796 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 1302863001797 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1302863001798 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1302863001799 catalytic residues [active] 1302863001800 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 1302863001801 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 1302863001802 SelR domain; Region: SelR; pfam01641 1302863001803 Response regulator receiver domain; Region: Response_reg; pfam00072 1302863001804 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302863001805 active site 1302863001806 phosphorylation site [posttranslational modification] 1302863001807 intermolecular recognition site; other site 1302863001808 dimerization interface [polypeptide binding]; other site 1302863001809 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1302863001810 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1302863001811 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1302863001812 Cache domain; Region: Cache_1; pfam02743 1302863001813 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1302863001814 dimerization interface [polypeptide binding]; other site 1302863001815 Histidine kinase; Region: His_kinase; pfam06580 1302863001816 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302863001817 ATP binding site [chemical binding]; other site 1302863001818 Mg2+ binding site [ion binding]; other site 1302863001819 G-X-G motif; other site 1302863001820 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 1302863001821 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1302863001822 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1302863001823 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1302863001824 catalytic residues [active] 1302863001825 Predicted flavoprotein [General function prediction only]; Region: COG0431 1302863001826 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1302863001827 PAS domain; Region: PAS_10; pfam13596 1302863001828 Predicted flavoprotein [General function prediction only]; Region: COG0431 1302863001829 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1302863001830 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 1302863001831 ApbE family; Region: ApbE; pfam02424 1302863001832 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 1302863001833 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1302863001834 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1302863001835 Protease prsW family; Region: PrsW-protease; pfam13367 1302863001836 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1302863001837 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1302863001838 Cl- selectivity filter; other site 1302863001839 Cl- binding residues [ion binding]; other site 1302863001840 pore gating glutamate residue; other site 1302863001841 dimer interface [polypeptide binding]; other site 1302863001842 H+/Cl- coupling transport residue; other site 1302863001843 TrkA-C domain; Region: TrkA_C; pfam02080 1302863001844 Imelysin; Region: Peptidase_M75; pfam09375 1302863001845 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1302863001846 High-affinity Fe2+/Pb2+ permease [Inorganic ion transport and metabolism]; Region: FTR1; COG0672 1302863001847 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 1302863001848 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 1302863001849 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 1302863001850 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1302863001851 active site 1302863001852 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1302863001853 active site 1302863001854 xanthine permease; Region: pbuX; TIGR03173 1302863001855 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1302863001856 multidrug efflux protein; Reviewed; Region: PRK01766 1302863001857 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1302863001858 cation binding site [ion binding]; other site 1302863001859 4-oxalocrotonate tautomerase; Provisional; Region: PRK02289 1302863001860 active site 1 [active] 1302863001861 dimer interface [polypeptide binding]; other site 1302863001862 hexamer interface [polypeptide binding]; other site 1302863001863 active site 2 [active] 1302863001864 thymidine kinase; Provisional; Region: PRK04296 1302863001865 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1302863001866 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1302863001867 RF-1 domain; Region: RF-1; pfam00472 1302863001868 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 1302863001869 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1302863001870 S-adenosylmethionine binding site [chemical binding]; other site 1302863001871 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1302863001872 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1302863001873 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1302863001874 dimer interface [polypeptide binding]; other site 1302863001875 active site 1302863001876 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1302863001877 folate binding site [chemical binding]; other site 1302863001878 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 1302863001879 Lysozyme-like; Region: Lysozyme_like; pfam13702 1302863001880 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1302863001881 GAF domain; Region: GAF_2; pfam13185 1302863001882 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 1302863001883 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1302863001884 Walker A motif; other site 1302863001885 ATP binding site [chemical binding]; other site 1302863001886 Walker B motif; other site 1302863001887 arginine finger; other site 1302863001888 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1302863001889 Protein of unknown function (DUF3272); Region: DUF3272; pfam11676 1302863001890 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1302863001891 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1302863001892 hinge; other site 1302863001893 active site 1302863001894 shikimate kinase; Reviewed; Region: aroK; PRK00131 1302863001895 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1302863001896 ADP binding site [chemical binding]; other site 1302863001897 magnesium binding site [ion binding]; other site 1302863001898 putative shikimate binding site; other site 1302863001899 prephenate dehydratase; Provisional; Region: PRK11898 1302863001900 Prephenate dehydratase; Region: PDT; pfam00800 1302863001901 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1302863001902 putative L-Phe binding site [chemical binding]; other site 1302863001903 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1302863001904 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1302863001905 TRAM domain; Region: TRAM; cl01282 1302863001906 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1302863001907 S-adenosylmethionine binding site [chemical binding]; other site 1302863001908 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1302863001909 homodimer interface [polypeptide binding]; other site 1302863001910 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1302863001911 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1302863001912 active site 1302863001913 homodimer interface [polypeptide binding]; other site 1302863001914 catalytic site [active] 1302863001915 Domain of unknown function (DUF4300); Region: DUF4300; pfam14133 1302863001916 Mga helix-turn-helix domain; Region: Mga; pfam05043 1302863001917 glycerol kinase; Provisional; Region: glpK; PRK00047 1302863001918 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1302863001919 N- and C-terminal domain interface [polypeptide binding]; other site 1302863001920 active site 1302863001921 MgATP binding site [chemical binding]; other site 1302863001922 catalytic site [active] 1302863001923 metal binding site [ion binding]; metal-binding site 1302863001924 glycerol binding site [chemical binding]; other site 1302863001925 homotetramer interface [polypeptide binding]; other site 1302863001926 homodimer interface [polypeptide binding]; other site 1302863001927 FBP binding site [chemical binding]; other site 1302863001928 protein IIAGlc interface [polypeptide binding]; other site 1302863001929 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1302863001930 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 1302863001931 amphipathic channel; other site 1302863001932 Asn-Pro-Ala signature motifs; other site 1302863001933 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1302863001934 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 1302863001935 putative oligomer interface [polypeptide binding]; other site 1302863001936 putative active site [active] 1302863001937 metal binding site [ion binding]; metal-binding site 1302863001938 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1302863001939 Serine hydrolase; Region: Ser_hydrolase; cl17834 1302863001940 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 1302863001941 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 1302863001942 active site 1302863001943 Na/Ca binding site [ion binding]; other site 1302863001944 catalytic site [active] 1302863001945 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 1302863001946 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 1302863001947 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482 1302863001948 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1302863001949 metal binding site [ion binding]; metal-binding site 1302863001950 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1302863001951 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1302863001952 Walker A/P-loop; other site 1302863001953 ATP binding site [chemical binding]; other site 1302863001954 Q-loop/lid; other site 1302863001955 ABC transporter signature motif; other site 1302863001956 Walker B; other site 1302863001957 D-loop; other site 1302863001958 H-loop/switch region; other site 1302863001959 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 1302863001960 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1302863001961 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 1302863001962 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 1302863001963 hypothetical protein; Validated; Region: PRK02101 1302863001964 TraX protein; Region: TraX; cl05434 1302863001965 topology modulation protein; Provisional; Region: PRK07261 1302863001966 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 1302863001967 active site 1302863001968 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1302863001969 pantothenate kinase; Provisional; Region: PRK05439 1302863001970 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1302863001971 ATP-binding site [chemical binding]; other site 1302863001972 CoA-binding site [chemical binding]; other site 1302863001973 Mg2+-binding site [ion binding]; other site 1302863001974 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 1302863001975 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1302863001976 S-adenosylmethionine binding site [chemical binding]; other site 1302863001977 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 1302863001978 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1302863001979 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1302863001980 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1302863001981 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1302863001982 intersubunit interface [polypeptide binding]; other site 1302863001983 active site 1302863001984 catalytic residue [active] 1302863001985 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1302863001986 active site 1302863001987 catalytic motif [active] 1302863001988 Zn binding site [ion binding]; other site 1302863001989 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 1302863001990 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 1302863001991 ligand binding site [chemical binding]; other site 1302863001992 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 1302863001993 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1302863001994 Walker A/P-loop; other site 1302863001995 ATP binding site [chemical binding]; other site 1302863001996 Q-loop/lid; other site 1302863001997 ABC transporter signature motif; other site 1302863001998 Walker B; other site 1302863001999 D-loop; other site 1302863002000 H-loop/switch region; other site 1302863002001 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1302863002002 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1302863002003 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1302863002004 TM-ABC transporter signature motif; other site 1302863002005 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1302863002006 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 1302863002007 TM-ABC transporter signature motif; other site 1302863002008 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1302863002009 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 1302863002010 putative active site [active] 1302863002011 putative metal binding site [ion binding]; other site 1302863002012 homoserine dehydrogenase; Provisional; Region: PRK06349 1302863002013 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1302863002014 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1302863002015 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1302863002016 homoserine kinase; Provisional; Region: PRK01212 1302863002017 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1302863002018 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1302863002019 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1302863002020 FAD binding domain; Region: FAD_binding_4; pfam01565 1302863002021 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1302863002022 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1302863002023 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 1302863002024 Walker A/P-loop; other site 1302863002025 ATP binding site [chemical binding]; other site 1302863002026 Q-loop/lid; other site 1302863002027 ABC transporter signature motif; other site 1302863002028 Walker B; other site 1302863002029 D-loop; other site 1302863002030 H-loop/switch region; other site 1302863002031 TOBE domain; Region: TOBE_2; pfam08402 1302863002032 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302863002033 dimer interface [polypeptide binding]; other site 1302863002034 conserved gate region; other site 1302863002035 putative PBP binding loops; other site 1302863002036 ABC-ATPase subunit interface; other site 1302863002037 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1302863002038 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302863002039 dimer interface [polypeptide binding]; other site 1302863002040 conserved gate region; other site 1302863002041 putative PBP binding loops; other site 1302863002042 ABC-ATPase subunit interface; other site 1302863002043 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1302863002044 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1302863002045 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 1302863002046 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1302863002047 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1302863002048 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 1302863002049 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1302863002050 dimer interface [polypeptide binding]; other site 1302863002051 active site 1302863002052 metal binding site [ion binding]; metal-binding site 1302863002053 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1302863002054 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1302863002055 active site 1302863002056 motif I; other site 1302863002057 motif II; other site 1302863002058 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1302863002059 gamma-glutamyl kinase; Provisional; Region: PRK05429 1302863002060 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1302863002061 nucleotide binding site [chemical binding]; other site 1302863002062 homotetrameric interface [polypeptide binding]; other site 1302863002063 putative phosphate binding site [ion binding]; other site 1302863002064 putative allosteric binding site; other site 1302863002065 PUA domain; Region: PUA; pfam01472 1302863002066 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1302863002067 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1302863002068 putative catalytic cysteine [active] 1302863002069 pyrroline-5-carboxylate reductase; Region: PLN02688 1302863002070 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 1302863002071 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 1302863002072 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 1302863002073 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1302863002074 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1302863002075 Coenzyme A binding pocket [chemical binding]; other site 1302863002076 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 1302863002077 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1302863002078 RNA binding site [nucleotide binding]; other site 1302863002079 active site 1302863002080 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 1302863002081 Glucan-binding protein C; Region: GbpC; pfam08363 1302863002082 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1302863002083 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1302863002084 active site 1302863002085 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1302863002086 binding surface 1302863002087 TPR repeat; Region: TPR_11; pfam13414 1302863002088 TPR motif; other site 1302863002089 peptidase T; Region: peptidase-T; TIGR01882 1302863002090 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1302863002091 metal binding site [ion binding]; metal-binding site 1302863002092 dimer interface [polypeptide binding]; other site 1302863002093 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 1302863002094 Protein of unknown function (DUF419); Region: DUF419; cl15265 1302863002095 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1302863002096 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1302863002097 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1302863002098 Walker A/P-loop; other site 1302863002099 ATP binding site [chemical binding]; other site 1302863002100 Q-loop/lid; other site 1302863002101 ABC transporter signature motif; other site 1302863002102 Walker B; other site 1302863002103 D-loop; other site 1302863002104 H-loop/switch region; other site 1302863002105 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 1302863002106 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1302863002107 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1302863002108 Walker A/P-loop; other site 1302863002109 ATP binding site [chemical binding]; other site 1302863002110 Q-loop/lid; other site 1302863002111 ABC transporter signature motif; other site 1302863002112 Walker B; other site 1302863002113 D-loop; other site 1302863002114 H-loop/switch region; other site 1302863002115 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1302863002116 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1302863002117 DNA-binding site [nucleotide binding]; DNA binding site 1302863002118 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1302863002119 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302863002120 homodimer interface [polypeptide binding]; other site 1302863002121 catalytic residue [active] 1302863002122 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 1302863002123 HTH domain; Region: HTH_11; pfam08279 1302863002124 3H domain; Region: 3H; pfam02829 1302863002125 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272 1302863002126 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 1302863002127 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1302863002128 PhnA protein; Region: PhnA; pfam03831 1302863002129 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 1302863002130 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1302863002131 active site 1302863002132 uracil transporter; Provisional; Region: PRK10720 1302863002133 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 1302863002134 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1302863002135 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1302863002136 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1302863002137 NH_3: A subgroup of nucleoside hydrolases. This group contains eukaryotic and bacterial proteins similar to nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes...; Region: nuc_hydro_3; cd02653 1302863002138 active site 1302863002139 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1302863002140 homotrimer interaction site [polypeptide binding]; other site 1302863002141 putative active site [active] 1302863002142 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 1302863002143 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1302863002144 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 1302863002145 dimer interface [polypeptide binding]; other site 1302863002146 phosphate binding site [ion binding]; other site 1302863002147 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 1302863002148 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 1302863002149 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 1302863002150 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1302863002151 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1302863002152 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 1302863002153 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1302863002154 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1302863002155 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1302863002156 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 1302863002157 Penicillinase repressor; Region: Pencillinase_R; pfam03965 1302863002158 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1302863002159 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1302863002160 S-adenosylmethionine binding site [chemical binding]; other site 1302863002161 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E_like proteins; Region: GAT1_Peptidase_E_like; cd03129 1302863002162 catalytic triad [active] 1302863002163 active site nucleophile [active] 1302863002164 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 1302863002165 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 1302863002166 Glucan-binding protein C; Region: GbpC; pfam08363 1302863002167 adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228 1302863002168 adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228 1302863002169 PrgI family protein; Region: PrgI; pfam12666 1302863002170 AAA-like domain; Region: AAA_10; pfam12846 1302863002171 Peptidase family M23; Region: Peptidase_M23; pfam01551 1302863002172 CHAP domain; Region: CHAP; pfam05257 1302863002173 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1302863002174 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1302863002175 Walker A motif; other site 1302863002176 ATP binding site [chemical binding]; other site 1302863002177 Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412 1302863002178 Walker B motif; other site 1302863002179 cell division protein MukB; Provisional; Region: mukB; PRK04863 1302863002180 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 1302863002181 Toprim-like; Region: Toprim_2; pfam13155 1302863002182 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 1302863002183 Domain of unknown function (DUF955); Region: DUF955; cl01076 1302863002184 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 1302863002185 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1302863002186 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1302863002187 P-loop; other site 1302863002188 Magnesium ion binding site [ion binding]; other site 1302863002189 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1302863002190 Magnesium ion binding site [ion binding]; other site 1302863002191 Fic family protein [Function unknown]; Region: COG3177 1302863002192 Fic/DOC family; Region: Fic; pfam02661 1302863002193 Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782 1302863002194 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1302863002195 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1302863002196 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 1302863002197 DNA primase, catalytic core; Region: dnaG; TIGR01391 1302863002198 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1302863002199 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1302863002200 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1302863002201 active site 1302863002202 metal binding site [ion binding]; metal-binding site 1302863002203 interdomain interaction site; other site 1302863002204 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1302863002205 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 1302863002206 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1302863002207 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1302863002208 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1302863002209 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1302863002210 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1302863002211 DNA binding residues [nucleotide binding] 1302863002212 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1302863002213 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1302863002214 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1302863002215 DNA-binding site [nucleotide binding]; DNA binding site 1302863002216 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1302863002217 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1302863002218 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 1302863002219 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1302863002220 DNA binding site [nucleotide binding] 1302863002221 domain linker motif; other site 1302863002222 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1302863002223 putative dimerization interface [polypeptide binding]; other site 1302863002224 putative ligand binding site [chemical binding]; other site 1302863002225 galactokinase; Provisional; Region: PRK05322 1302863002226 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1302863002227 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1302863002228 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1302863002229 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 1302863002230 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 1302863002231 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 1302863002232 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1302863002233 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1302863002234 NAD binding site [chemical binding]; other site 1302863002235 homodimer interface [polypeptide binding]; other site 1302863002236 active site 1302863002237 substrate binding site [chemical binding]; other site 1302863002238 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1302863002239 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1302863002240 active site 1302863002241 Riboflavin kinase; Region: Flavokinase; smart00904 1302863002242 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1302863002243 ArsC family; Region: ArsC; pfam03960 1302863002244 putative catalytic residues [active] 1302863002245 thiol/disulfide switch; other site 1302863002246 Uncharacterized protein family (UPF0223); Region: UPF0223; cl11484 1302863002247 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1302863002248 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1302863002249 active site 1302863002250 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 1302863002251 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1302863002252 S-adenosylmethionine binding site [chemical binding]; other site 1302863002253 Uncharacterized conserved protein [Function unknown]; Region: COG3270 1302863002254 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 1302863002255 phosphate binding protein; Region: ptsS_2; TIGR02136 1302863002256 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1302863002257 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1302863002258 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302863002259 dimer interface [polypeptide binding]; other site 1302863002260 conserved gate region; other site 1302863002261 putative PBP binding loops; other site 1302863002262 ABC-ATPase subunit interface; other site 1302863002263 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 1302863002264 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302863002265 dimer interface [polypeptide binding]; other site 1302863002266 conserved gate region; other site 1302863002267 putative PBP binding loops; other site 1302863002268 ABC-ATPase subunit interface; other site 1302863002269 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 1302863002270 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1302863002271 Walker A/P-loop; other site 1302863002272 ATP binding site [chemical binding]; other site 1302863002273 Q-loop/lid; other site 1302863002274 ABC transporter signature motif; other site 1302863002275 Walker B; other site 1302863002276 D-loop; other site 1302863002277 H-loop/switch region; other site 1302863002278 phosphate transporter ATP-binding protein; Provisional; Region: PRK14239 1302863002279 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1302863002280 Walker A/P-loop; other site 1302863002281 ATP binding site [chemical binding]; other site 1302863002282 Q-loop/lid; other site 1302863002283 ABC transporter signature motif; other site 1302863002284 Walker B; other site 1302863002285 D-loop; other site 1302863002286 H-loop/switch region; other site 1302863002287 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1302863002288 PhoU domain; Region: PhoU; pfam01895 1302863002289 PhoU domain; Region: PhoU; pfam01895 1302863002290 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 1302863002291 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 1302863002292 Zn binding site [ion binding]; other site 1302863002293 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1302863002294 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302863002295 active site 1302863002296 phosphorylation site [posttranslational modification] 1302863002297 intermolecular recognition site; other site 1302863002298 dimerization interface [polypeptide binding]; other site 1302863002299 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1302863002300 DNA binding site [nucleotide binding] 1302863002301 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1302863002302 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1302863002303 dimer interface [polypeptide binding]; other site 1302863002304 phosphorylation site [posttranslational modification] 1302863002305 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302863002306 ATP binding site [chemical binding]; other site 1302863002307 Mg2+ binding site [ion binding]; other site 1302863002308 G-X-G motif; other site 1302863002309 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1302863002310 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1302863002311 dimer interface [polypeptide binding]; other site 1302863002312 active site 1302863002313 metal binding site [ion binding]; metal-binding site 1302863002314 glutathione binding site [chemical binding]; other site 1302863002315 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1302863002316 Catalytic NodB homology domain of Streptococcus pneumoniae peptidoglycan deacetylase PgdA, Bacillus subtilis BsYjeA protein, and their bacterial homologs; Region: CE4_SpPgdA_BsYjeA_like; cd10947 1302863002317 NodB motif; other site 1302863002318 active site 1302863002319 catalytic site [active] 1302863002320 Zn binding site [ion binding]; other site 1302863002321 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1302863002322 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1302863002323 ATP binding site [chemical binding]; other site 1302863002324 putative Mg++ binding site [ion binding]; other site 1302863002325 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1302863002326 nucleotide binding region [chemical binding]; other site 1302863002327 ATP-binding site [chemical binding]; other site 1302863002328 potential frameshift: common BLAST hit: gi|125717802|ref|YP_001034935.1| oxidoreductase 1302863002329 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1302863002330 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1302863002331 Sugar specificity; other site 1302863002332 Pyrimidine base specificity; other site 1302863002333 ATP-binding site [chemical binding]; other site 1302863002334 Protein of unknown function (DUF1275); Region: DUF1275; pfam06912 1302863002335 Protein of unknown function (DUF443); Region: DUF443; cl04467 1302863002336 Domain of unknown function (DUF4176); Region: DUF4176; pfam13780 1302863002337 2-isopropylmalate synthase; Validated; Region: PRK00915 1302863002338 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1302863002339 active site 1302863002340 catalytic residues [active] 1302863002341 metal binding site [ion binding]; metal-binding site 1302863002342 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1302863002343 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1302863002344 tartrate dehydrogenase; Region: TTC; TIGR02089 1302863002345 Predicted membrane protein [Function unknown]; Region: COG3326 1302863002346 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1302863002347 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1302863002348 substrate binding site [chemical binding]; other site 1302863002349 ligand binding site [chemical binding]; other site 1302863002350 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 1302863002351 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1302863002352 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1302863002353 substrate binding site [chemical binding]; other site 1302863002354 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 1302863002355 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1302863002356 putative DNA binding site [nucleotide binding]; other site 1302863002357 putative Zn2+ binding site [ion binding]; other site 1302863002358 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1302863002359 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 1302863002360 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1302863002361 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1302863002362 Walker A/P-loop; other site 1302863002363 ATP binding site [chemical binding]; other site 1302863002364 Q-loop/lid; other site 1302863002365 ABC transporter signature motif; other site 1302863002366 Walker B; other site 1302863002367 D-loop; other site 1302863002368 H-loop/switch region; other site 1302863002369 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302863002370 dimer interface [polypeptide binding]; other site 1302863002371 conserved gate region; other site 1302863002372 putative PBP binding loops; other site 1302863002373 ABC-ATPase subunit interface; other site 1302863002374 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1302863002375 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 1302863002376 TfoX N-terminal domain; Region: TfoX_N; cl17592 1302863002377 potential frameshift: common BLAST hit: gi|392428708|ref|YP_006469719.1| ABC transporter ATPase/permease 1302863002378 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 1302863002379 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1302863002380 Predicted secreted protein [Function unknown]; Region: COG4086 1302863002381 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 1302863002382 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1302863002383 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1302863002384 Int/Topo IB signature motif; other site 1302863002385 Domain of unknown function (DUF3173); Region: DUF3173; pfam11372 1302863002386 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1302863002387 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1302863002388 non-specific DNA binding site [nucleotide binding]; other site 1302863002389 salt bridge; other site 1302863002390 sequence-specific DNA binding site [nucleotide binding]; other site 1302863002391 Zeta toxin; Region: Zeta_toxin; pfam06414 1302863002392 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185 1302863002393 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1302863002394 putative metalloenzyme radical SAM/SPASM domain maturase; Region: rSAM_Geo_metal; TIGR04311 1302863002395 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1302863002396 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1302863002397 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 1302863002398 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1302863002399 Walker A/P-loop; other site 1302863002400 ATP binding site [chemical binding]; other site 1302863002401 Q-loop/lid; other site 1302863002402 ABC transporter signature motif; other site 1302863002403 Walker B; other site 1302863002404 D-loop; other site 1302863002405 H-loop/switch region; other site 1302863002406 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 1302863002407 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1302863002408 GMP synthase; Reviewed; Region: guaA; PRK00074 1302863002409 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1302863002410 AMP/PPi binding site [chemical binding]; other site 1302863002411 candidate oxyanion hole; other site 1302863002412 catalytic triad [active] 1302863002413 potential glutamine specificity residues [chemical binding]; other site 1302863002414 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1302863002415 ATP Binding subdomain [chemical binding]; other site 1302863002416 Dimerization subdomain; other site 1302863002417 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1302863002418 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1302863002419 DNA-binding site [nucleotide binding]; DNA binding site 1302863002420 UTRA domain; Region: UTRA; pfam07702 1302863002421 putative DNA-binding protein; Validated; Region: PRK00118 1302863002422 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 1302863002423 signal recognition particle protein; Provisional; Region: PRK10867 1302863002424 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1302863002425 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1302863002426 P loop; other site 1302863002427 GTP binding site [chemical binding]; other site 1302863002428 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1302863002429 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 1302863002430 MepB protein; Region: MepB; pfam08877 1302863002431 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 1302863002432 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1302863002433 active site 1302863002434 DNA binding site [nucleotide binding] 1302863002435 Int/Topo IB signature motif; other site 1302863002436 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1302863002437 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 1302863002438 Walker A/P-loop; other site 1302863002439 ATP binding site [chemical binding]; other site 1302863002440 Q-loop/lid; other site 1302863002441 ABC transporter signature motif; other site 1302863002442 Walker B; other site 1302863002443 D-loop; other site 1302863002444 H-loop/switch region; other site 1302863002445 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 1302863002446 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 1302863002447 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1302863002448 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 1302863002449 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1302863002450 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1302863002451 E3 interaction surface; other site 1302863002452 lipoyl attachment site [posttranslational modification]; other site 1302863002453 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 1302863002454 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1302863002455 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1302863002456 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1302863002457 dihydrolipoamide acetyltransferase; Provisional; Region: PRK14843 1302863002458 e3 binding domain; Region: E3_binding; pfam02817 1302863002459 e3 binding domain; Region: E3_binding; pfam02817 1302863002460 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1302863002461 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1302863002462 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1302863002463 alpha subunit interface [polypeptide binding]; other site 1302863002464 TPP binding site [chemical binding]; other site 1302863002465 heterodimer interface [polypeptide binding]; other site 1302863002466 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1302863002467 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 1302863002468 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1302863002469 tetramer interface [polypeptide binding]; other site 1302863002470 TPP-binding site [chemical binding]; other site 1302863002471 heterodimer interface [polypeptide binding]; other site 1302863002472 phosphorylation loop region [posttranslational modification] 1302863002473 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 1302863002474 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 1302863002475 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1302863002476 Putative esterase; Region: Esterase; pfam00756 1302863002477 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 1302863002478 Glucose inhibited division protein A; Region: GIDA; pfam01134 1302863002479 DNA topoisomerase I; Validated; Region: PRK05582 1302863002480 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1302863002481 active site 1302863002482 interdomain interaction site; other site 1302863002483 putative metal-binding site [ion binding]; other site 1302863002484 nucleotide binding site [chemical binding]; other site 1302863002485 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1302863002486 domain I; other site 1302863002487 DNA binding groove [nucleotide binding] 1302863002488 phosphate binding site [ion binding]; other site 1302863002489 domain II; other site 1302863002490 domain III; other site 1302863002491 nucleotide binding site [chemical binding]; other site 1302863002492 catalytic site [active] 1302863002493 domain IV; other site 1302863002494 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1302863002495 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1302863002496 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1302863002497 DNA protecting protein DprA; Region: dprA; TIGR00732 1302863002498 maltose O-acetyltransferase; Provisional; Region: PRK10092 1302863002499 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1302863002500 active site 1302863002501 substrate binding site [chemical binding]; other site 1302863002502 trimer interface [polypeptide binding]; other site 1302863002503 CoA binding site [chemical binding]; other site 1302863002504 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1302863002505 RNA/DNA hybrid binding site [nucleotide binding]; other site 1302863002506 active site 1302863002507 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 1302863002508 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 1302863002509 GTP/Mg2+ binding site [chemical binding]; other site 1302863002510 G4 box; other site 1302863002511 G5 box; other site 1302863002512 G1 box; other site 1302863002513 Switch I region; other site 1302863002514 G2 box; other site 1302863002515 G3 box; other site 1302863002516 Switch II region; other site 1302863002517 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1302863002518 snRNA-activating protein of 50kDa MW C terminal; Region: zf-SNAP50_C; pfam12251 1302863002519 isovaleryl-CoA dehydrogenase; Region: PLN02519 1302863002520 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 1302863002521 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1302863002522 active site 1302863002523 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1302863002524 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1302863002525 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1302863002526 dimerization interface [polypeptide binding]; other site 1302863002527 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1302863002528 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 1302863002529 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 1302863002530 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1302863002531 substrate binding site [chemical binding]; other site 1302863002532 oxyanion hole (OAH) forming residues; other site 1302863002533 trimer interface [polypeptide binding]; other site 1302863002534 putative acyltransferase; Provisional; Region: PRK05790 1302863002535 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1302863002536 dimer interface [polypeptide binding]; other site 1302863002537 active site 1302863002538 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK05808 1302863002539 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1302863002540 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1302863002541 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1302863002542 acyl-coenzyme A oxidase; Region: PLN02526 1302863002543 active site 1302863002544 ATP cone domain; Region: ATP-cone; pfam03477 1302863002545 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1302863002546 Coenzyme A binding pocket [chemical binding]; other site 1302863002547 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1302863002548 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1302863002549 dimer interface [polypeptide binding]; other site 1302863002550 active site 1302863002551 catalytic residue [active] 1302863002552 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 1302863002553 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1302863002554 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 1302863002555 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 1302863002556 active site 1302863002557 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1302863002558 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1302863002559 Coenzyme A binding pocket [chemical binding]; other site 1302863002560 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 1302863002561 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 1302863002562 Potassium binding sites [ion binding]; other site 1302863002563 Cesium cation binding sites [ion binding]; other site 1302863002564 phosphopantothenate--cysteine ligase; Validated; Region: PRK06732 1302863002565 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313 1302863002566 Flavoprotein; Region: Flavoprotein; pfam02441 1302863002567 Predicted membrane protein [Function unknown]; Region: COG4684 1302863002568 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 1302863002569 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 1302863002570 active site 1302863002571 substrate binding site [chemical binding]; other site 1302863002572 metal binding site [ion binding]; metal-binding site 1302863002573 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1302863002574 catalytic residues [active] 1302863002575 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 1302863002576 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1302863002577 minor groove reading motif; other site 1302863002578 helix-hairpin-helix signature motif; other site 1302863002579 substrate binding pocket [chemical binding]; other site 1302863002580 active site 1302863002581 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1302863002582 DNA binding and oxoG recognition site [nucleotide binding] 1302863002583 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 1302863002584 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1302863002585 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1302863002586 active site 1302863002587 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 1302863002588 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1302863002589 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1302863002590 synthetase active site [active] 1302863002591 NTP binding site [chemical binding]; other site 1302863002592 metal binding site [ion binding]; metal-binding site 1302863002593 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 1302863002594 putative active site [active] 1302863002595 putative metal binding residues [ion binding]; other site 1302863002596 signature motif; other site 1302863002597 putative triphosphate binding site [ion binding]; other site 1302863002598 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458 1302863002599 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1302863002600 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1302863002601 active site 1302863002602 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1302863002603 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1302863002604 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1302863002605 catalytic residue [active] 1302863002606 Putative amino acid metabolism; Region: DUF1831; pfam08866 1302863002607 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 1302863002608 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 1302863002609 CoA binding domain; Region: CoA_binding; pfam02629 1302863002610 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1302863002611 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1302863002612 catalytic triad [active] 1302863002613 hypothetical protein; Reviewed; Region: PRK00024 1302863002614 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1302863002615 MPN+ (JAMM) motif; other site 1302863002616 Zinc-binding site [ion binding]; other site 1302863002617 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 1302863002618 active site 1302863002619 catalytic site [active] 1302863002620 DNA gyrase subunit A; Validated; Region: PRK05560 1302863002621 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1302863002622 CAP-like domain; other site 1302863002623 active site 1302863002624 primary dimer interface [polypeptide binding]; other site 1302863002625 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1302863002626 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1302863002627 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1302863002628 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1302863002629 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1302863002630 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1302863002631 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 1302863002632 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 1302863002633 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1302863002634 NAD binding site [chemical binding]; other site 1302863002635 dimer interface [polypeptide binding]; other site 1302863002636 substrate binding site [chemical binding]; other site 1302863002637 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1302863002638 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1302863002639 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1302863002640 peptide binding site [polypeptide binding]; other site 1302863002641 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 1302863002642 putative homodimer interface [polypeptide binding]; other site 1302863002643 putative homotetramer interface [polypeptide binding]; other site 1302863002644 putative metal binding site [ion binding]; other site 1302863002645 putative homodimer-homodimer interface [polypeptide binding]; other site 1302863002646 putative allosteric switch controlling residues; other site 1302863002647 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1302863002648 active site residue [active] 1302863002649 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1302863002650 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 1302863002651 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1302863002652 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1302863002653 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 1302863002654 active site residue [active] 1302863002655 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1302863002656 active site residue [active] 1302863002657 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1302863002658 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 1302863002659 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1302863002660 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 1302863002661 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1302863002662 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1302863002663 Ligand Binding Site [chemical binding]; other site 1302863002664 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1302863002665 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1302863002666 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1302863002667 catalytic residue [active] 1302863002668 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1302863002669 This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335 1302863002670 putative deacylase active site [active] 1302863002671 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 1302863002672 putative uracil binding site [chemical binding]; other site 1302863002673 putative active site [active] 1302863002674 dipeptidase PepV; Reviewed; Region: PRK07318 1302863002675 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1302863002676 active site 1302863002677 metal binding site [ion binding]; metal-binding site 1302863002678 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 1302863002679 dimer interface [polypeptide binding]; other site 1302863002680 FMN binding site [chemical binding]; other site 1302863002681 Domain of unknown function (DUF1911); Region: DUF1911; pfam08929 1302863002682 Protein of unknown function, DUF600; Region: DUF600; cl04640 1302863002683 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1302863002684 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 1302863002685 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1302863002686 active site 1302863002687 metal binding site [ion binding]; metal-binding site 1302863002688 Domain of unknown function (DUF4274); Region: DUF4274; pfam14096 1302863002689 Immunity protein Imm6; Region: Imm6; pfam14434 1302863002690 Immunity protein Imm6; Region: Imm6; pfam14434 1302863002691 Domain of unknown function (DUF4284); Region: DUF4284; pfam14112 1302863002692 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1302863002693 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 1302863002694 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1302863002695 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 1302863002696 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1302863002697 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1302863002698 GIY-YIG motif/motif A; other site 1302863002699 active site 1302863002700 catalytic site [active] 1302863002701 putative DNA binding site [nucleotide binding]; other site 1302863002702 metal binding site [ion binding]; metal-binding site 1302863002703 UvrB/uvrC motif; Region: UVR; pfam02151 1302863002704 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1302863002705 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 1302863002706 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1302863002707 C-terminal domain interface [polypeptide binding]; other site 1302863002708 active site 1302863002709 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1302863002710 active site 1302863002711 N-terminal domain interface [polypeptide binding]; other site 1302863002712 Protein of unknown function (DUF745); Region: DUF745; pfam05335 1302863002713 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 1302863002714 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 1302863002715 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 1302863002716 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 1302863002717 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 1302863002718 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1302863002719 metal binding site [ion binding]; metal-binding site 1302863002720 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1302863002721 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1302863002722 RimM N-terminal domain; Region: RimM; pfam01782 1302863002723 PRC-barrel domain; Region: PRC; pfam05239 1302863002724 conserved hypothetical protein; Region: TIGR02328 1302863002725 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013 1302863002726 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1302863002727 Coenzyme A binding pocket [chemical binding]; other site 1302863002728 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 1302863002729 TrkA-N domain; Region: TrkA_N; pfam02254 1302863002730 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1302863002731 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1302863002732 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 1302863002733 KH domain; Region: KH_4; pfam13083 1302863002734 G-X-X-G motif; other site 1302863002735 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 1302863002736 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 1302863002737 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1302863002738 motif II; other site 1302863002739 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 1302863002740 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1302863002741 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1302863002742 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 1302863002743 Flagellin N-methylase; Region: FliB; pfam03692 1302863002744 GTP-binding protein LepA; Provisional; Region: PRK05433 1302863002745 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1302863002746 G1 box; other site 1302863002747 putative GEF interaction site [polypeptide binding]; other site 1302863002748 GTP/Mg2+ binding site [chemical binding]; other site 1302863002749 Switch I region; other site 1302863002750 G2 box; other site 1302863002751 G3 box; other site 1302863002752 Switch II region; other site 1302863002753 G4 box; other site 1302863002754 G5 box; other site 1302863002755 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1302863002756 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1302863002757 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1302863002758 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1302863002759 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1302863002760 RNA binding surface [nucleotide binding]; other site 1302863002761 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1302863002762 active site 1302863002763 lipoprotein signal peptidase; Provisional; Region: PRK14797 1302863002764 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1302863002765 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1302863002766 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1302863002767 dimerization interface [polypeptide binding]; other site 1302863002768 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 1302863002769 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1302863002770 gating phenylalanine in ion channel; other site 1302863002771 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1302863002772 Coenzyme A binding pocket [chemical binding]; other site 1302863002773 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1302863002774 Coenzyme A binding pocket [chemical binding]; other site 1302863002775 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1302863002776 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1302863002777 Walker A/P-loop; other site 1302863002778 ATP binding site [chemical binding]; other site 1302863002779 Q-loop/lid; other site 1302863002780 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1302863002781 ABC transporter; Region: ABC_tran_2; pfam12848 1302863002782 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1302863002783 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 1302863002784 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1302863002785 active site 1302863002786 NTP binding site [chemical binding]; other site 1302863002787 metal binding triad [ion binding]; metal-binding site 1302863002788 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1302863002789 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 1302863002790 dihydrodipicolinate reductase; Provisional; Region: PRK00048 1302863002791 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1302863002792 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1302863002793 EDD domain protein, DegV family; Region: DegV; TIGR00762 1302863002794 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1302863002795 Protein of unknown function (DUF1149); Region: DUF1149; pfam06619 1302863002796 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1302863002797 metal ion-dependent adhesion site (MIDAS); other site 1302863002798 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1302863002799 active site 1302863002800 phosphorylation site [posttranslational modification] 1302863002801 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1302863002802 active site 1302863002803 P-loop; other site 1302863002804 phosphorylation site [posttranslational modification] 1302863002805 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425 1302863002806 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1302863002807 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1302863002808 putative substrate binding site [chemical binding]; other site 1302863002809 putative ATP binding site [chemical binding]; other site 1302863002810 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1302863002811 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1302863002812 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1302863002813 CAAX protease self-immunity; Region: Abi; pfam02517 1302863002814 Predicted membrane protein [Function unknown]; Region: COG4478 1302863002815 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 1302863002816 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1302863002817 active site 1302863002818 motif I; other site 1302863002819 motif II; other site 1302863002820 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1302863002821 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 1302863002822 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1302863002823 active site 1302863002824 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1302863002825 active site 2 [active] 1302863002826 active site 1 [active] 1302863002827 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 1302863002828 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1302863002829 FeS/SAM binding site; other site 1302863002830 HemN C-terminal domain; Region: HemN_C; pfam06969 1302863002831 Cupin domain; Region: Cupin_2; cl17218 1302863002832 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1302863002833 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1302863002834 NAD binding site [chemical binding]; other site 1302863002835 substrate binding site [chemical binding]; other site 1302863002836 homodimer interface [polypeptide binding]; other site 1302863002837 active site 1302863002838 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 1302863002839 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1302863002840 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1302863002841 substrate binding site; other site 1302863002842 tetramer interface; other site 1302863002843 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1302863002844 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1302863002845 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1302863002846 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1302863002847 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 1302863002848 Family of unknown function (DUF633); Region: DUF633; pfam04816 1302863002849 LXG domain of WXG superfamily; Region: LXG; pfam04740 1302863002850 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 1302863002851 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 1302863002852 Homoserine O-succinyltransferase; Region: HTS; pfam04204 1302863002853 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1302863002854 proposed active site lysine [active] 1302863002855 conserved cys residue [active] 1302863002856 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1302863002857 active site 1302863002858 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1302863002859 DHH family; Region: DHH; pfam01368 1302863002860 DHHA1 domain; Region: DHHA1; pfam02272 1302863002861 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 1302863002862 potential frameshift: common BLAST hit: gi|125718238|ref|YP_001035371.1| hydrolase 1302863002863 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1302863002864 active site 1302863002865 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 1302863002866 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 1302863002867 Domain of unknown function (DUF4356); Region: DUF4356; pfam14266 1302863002868 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 1302863002869 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1302863002870 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1302863002871 putative metal binding site [ion binding]; other site 1302863002872 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1302863002873 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1302863002874 putative metal binding site [ion binding]; other site 1302863002875 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 1302863002876 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 1302863002877 putative metal binding site [ion binding]; other site 1302863002878 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1302863002879 plasma-membrane calcium-translocating P-type ATPase; Region: ATPase-IIB_Ca; TIGR01517 1302863002880 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1302863002881 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1302863002882 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1302863002883 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1302863002884 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1302863002885 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1302863002886 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1302863002887 Helix-turn-helix domain; Region: HTH_38; pfam13936 1302863002888 Integrase core domain; Region: rve; pfam00665 1302863002889 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1302863002890 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1302863002891 S-adenosylmethionine binding site [chemical binding]; other site 1302863002892 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 1302863002893 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1302863002894 NAD(P) binding site [chemical binding]; other site 1302863002895 active site 1302863002896 ribonuclease Z; Region: RNase_Z; TIGR02651 1302863002897 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 1302863002898 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1302863002899 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1302863002900 HflX GTPase family; Region: HflX; cd01878 1302863002901 G1 box; other site 1302863002902 GTP/Mg2+ binding site [chemical binding]; other site 1302863002903 Switch I region; other site 1302863002904 G2 box; other site 1302863002905 G3 box; other site 1302863002906 Switch II region; other site 1302863002907 G4 box; other site 1302863002908 G5 box; other site 1302863002909 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1302863002910 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1302863002911 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1302863002912 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1302863002913 ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264 1302863002914 Walker A/P-loop; other site 1302863002915 ATP binding site [chemical binding]; other site 1302863002916 Q-loop/lid; other site 1302863002917 ABC transporter signature motif; other site 1302863002918 Walker B; other site 1302863002919 D-loop; other site 1302863002920 H-loop/switch region; other site 1302863002921 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1302863002922 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 1302863002923 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1302863002924 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302863002925 active site 1302863002926 phosphorylation site [posttranslational modification] 1302863002927 intermolecular recognition site; other site 1302863002928 dimerization interface [polypeptide binding]; other site 1302863002929 LytTr DNA-binding domain; Region: LytTR; pfam04397 1302863002930 LytTr DNA-binding domain; Region: LytTR; smart00850 1302863002931 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1302863002932 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1302863002933 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 1302863002934 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1302863002935 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1302863002936 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1302863002937 non-specific DNA binding site [nucleotide binding]; other site 1302863002938 salt bridge; other site 1302863002939 sequence-specific DNA binding site [nucleotide binding]; other site 1302863002940 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1302863002941 Predicted transcriptional regulator [Transcription]; Region: COG2932 1302863002942 Catalytic site [active] 1302863002943 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1302863002944 catalytic core [active] 1302863002945 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1302863002946 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1302863002947 metal binding site 2 [ion binding]; metal-binding site 1302863002948 putative DNA binding helix; other site 1302863002949 metal binding site 1 [ion binding]; metal-binding site 1302863002950 dimer interface [polypeptide binding]; other site 1302863002951 structural Zn2+ binding site [ion binding]; other site 1302863002952 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1302863002953 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302863002954 putative substrate translocation pore; other site 1302863002955 chlorohydrolase; Validated; Region: PRK06687 1302863002956 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1302863002957 active site 1302863002958 putative substrate binding pocket [chemical binding]; other site 1302863002959 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1302863002960 IHF dimer interface [polypeptide binding]; other site 1302863002961 IHF - DNA interface [nucleotide binding]; other site 1302863002962 EDD domain protein, DegV family; Region: DegV; TIGR00762 1302863002963 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1302863002964 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1302863002965 Rib/alpha-like repeat; Region: Rib; pfam08428 1302863002966 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 1302863002967 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1302863002968 active site 1302863002969 metal binding site [ion binding]; metal-binding site 1302863002970 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1302863002971 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1302863002972 Walker A/P-loop; other site 1302863002973 ATP binding site [chemical binding]; other site 1302863002974 Q-loop/lid; other site 1302863002975 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1302863002976 ABC transporter signature motif; other site 1302863002977 Walker B; other site 1302863002978 D-loop; other site 1302863002979 H-loop/switch region; other site 1302863002980 Arginine repressor [Transcription]; Region: ArgR; COG1438 1302863002981 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1302863002982 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1302863002983 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 1302863002984 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1302863002985 RNA binding surface [nucleotide binding]; other site 1302863002986 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1302863002987 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1302863002988 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1302863002989 substrate binding pocket [chemical binding]; other site 1302863002990 chain length determination region; other site 1302863002991 substrate-Mg2+ binding site; other site 1302863002992 catalytic residues [active] 1302863002993 aspartate-rich region 1; other site 1302863002994 active site lid residues [active] 1302863002995 aspartate-rich region 2; other site 1302863002996 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1302863002997 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1302863002998 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1302863002999 generic binding surface II; other site 1302863003000 generic binding surface I; other site 1302863003001 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1302863003002 putative substrate binding site [chemical binding]; other site 1302863003003 putative ATP binding site [chemical binding]; other site 1302863003004 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 1302863003005 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1302863003006 Walker A/P-loop; other site 1302863003007 ATP binding site [chemical binding]; other site 1302863003008 Q-loop/lid; other site 1302863003009 ABC transporter signature motif; other site 1302863003010 Walker B; other site 1302863003011 D-loop; other site 1302863003012 H-loop/switch region; other site 1302863003013 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 1302863003014 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1302863003015 Walker A/P-loop; other site 1302863003016 ATP binding site [chemical binding]; other site 1302863003017 Q-loop/lid; other site 1302863003018 ABC transporter signature motif; other site 1302863003019 Walker B; other site 1302863003020 D-loop; other site 1302863003021 H-loop/switch region; other site 1302863003022 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1302863003023 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1302863003024 TM-ABC transporter signature motif; other site 1302863003025 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1302863003026 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1302863003027 TM-ABC transporter signature motif; other site 1302863003028 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1302863003029 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 1302863003030 putative ligand binding site [chemical binding]; other site 1302863003031 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 1302863003032 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1302863003033 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1302863003034 oligomer interface [polypeptide binding]; other site 1302863003035 active site residues [active] 1302863003036 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1302863003037 active site 1302863003038 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1302863003039 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1302863003040 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1302863003041 P loop; other site 1302863003042 GTP binding site [chemical binding]; other site 1302863003043 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1302863003044 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1302863003045 motif II; other site 1302863003046 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1302863003047 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1302863003048 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1302863003049 active site 1302863003050 motif I; other site 1302863003051 motif II; other site 1302863003052 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1302863003053 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1302863003054 nucleoside/Zn binding site; other site 1302863003055 catalytic motif [active] 1302863003056 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1302863003057 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1302863003058 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1302863003059 Walker A/P-loop; other site 1302863003060 ATP binding site [chemical binding]; other site 1302863003061 Q-loop/lid; other site 1302863003062 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 1302863003063 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1302863003064 ABC transporter signature motif; other site 1302863003065 Walker B; other site 1302863003066 D-loop; other site 1302863003067 H-loop/switch region; other site 1302863003068 ribonuclease III; Reviewed; Region: rnc; PRK00102 1302863003069 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1302863003070 dimerization interface [polypeptide binding]; other site 1302863003071 active site 1302863003072 metal binding site [ion binding]; metal-binding site 1302863003073 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1302863003074 dsRNA binding site [nucleotide binding]; other site 1302863003075 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 1302863003076 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1302863003077 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1302863003078 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 1302863003079 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1302863003080 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1302863003081 putative active site [active] 1302863003082 heme pocket [chemical binding]; other site 1302863003083 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1302863003084 dimer interface [polypeptide binding]; other site 1302863003085 phosphorylation site [posttranslational modification] 1302863003086 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302863003087 ATP binding site [chemical binding]; other site 1302863003088 Mg2+ binding site [ion binding]; other site 1302863003089 G-X-G motif; other site 1302863003090 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1302863003091 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302863003092 active site 1302863003093 phosphorylation site [posttranslational modification] 1302863003094 intermolecular recognition site; other site 1302863003095 dimerization interface [polypeptide binding]; other site 1302863003096 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1302863003097 DNA binding site [nucleotide binding] 1302863003098 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1302863003099 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1302863003100 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1302863003101 active site 1302863003102 Predicted transcriptional regulator [Transcription]; Region: COG1959 1302863003103 Transcriptional regulator; Region: Rrf2; pfam02082 1302863003104 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1302863003105 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1302863003106 active site 1302863003107 metal binding site [ion binding]; metal-binding site 1302863003108 FtsX-like permease family; Region: FtsX; pfam02687 1302863003109 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1302863003110 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1302863003111 FtsX-like permease family; Region: FtsX; pfam02687 1302863003112 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1302863003113 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1302863003114 Walker A/P-loop; other site 1302863003115 ATP binding site [chemical binding]; other site 1302863003116 Q-loop/lid; other site 1302863003117 ABC transporter signature motif; other site 1302863003118 Walker B; other site 1302863003119 D-loop; other site 1302863003120 H-loop/switch region; other site 1302863003121 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1302863003122 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1302863003123 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1302863003124 Peptidase family U32; Region: Peptidase_U32; pfam01136 1302863003125 Protein of unknown function (DUF3270); Region: DUF3270; pfam11674 1302863003126 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1302863003127 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 1302863003128 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 1302863003129 HPr kinase/phosphorylase; Provisional; Region: PRK05428 1302863003130 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 1302863003131 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 1302863003132 Hpr binding site; other site 1302863003133 active site 1302863003134 homohexamer subunit interaction site [polypeptide binding]; other site 1302863003135 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 1302863003136 nudix motif; other site 1302863003137 PspC domain; Region: PspC; pfam04024 1302863003138 hypothetical protein; Provisional; Region: PRK04351 1302863003139 SprT homologues; Region: SprT; cl01182 1302863003140 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1302863003141 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1302863003142 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1302863003143 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1302863003144 RNA binding site [nucleotide binding]; other site 1302863003145 Predicted permeases [General function prediction only]; Region: COG0701 1302863003146 Predicted membrane protein [Function unknown]; Region: COG3689 1302863003147 potential frameshift: common BLAST hit: gi|125718839|ref|YP_001035972.1| arabinose efflux permease 1302863003148 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1302863003149 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1302863003150 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1302863003151 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 1302863003152 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1302863003153 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1302863003154 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1302863003155 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1302863003156 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1302863003157 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1302863003158 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1302863003159 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302863003160 homodimer interface [polypeptide binding]; other site 1302863003161 catalytic residue [active] 1302863003162 cystathionine gamma-synthase; Reviewed; Region: PRK07269 1302863003163 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1302863003164 homodimer interface [polypeptide binding]; other site 1302863003165 substrate-cofactor binding pocket; other site 1302863003166 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302863003167 catalytic residue [active] 1302863003168 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1302863003169 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 1302863003170 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 1302863003171 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1302863003172 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1302863003173 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1302863003174 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 1302863003175 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 1302863003176 DHH family; Region: DHH; pfam01368 1302863003177 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 1302863003178 DHHA2 domain; Region: DHHA2; pfam02833 1302863003179 Amino acid permease; Region: AA_permease_2; pfam13520 1302863003180 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1302863003181 mRNA/rRNA interface [nucleotide binding]; other site 1302863003182 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1302863003183 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1302863003184 23S rRNA interface [nucleotide binding]; other site 1302863003185 L7/L12 interface [polypeptide binding]; other site 1302863003186 putative thiostrepton binding site; other site 1302863003187 L25 interface [polypeptide binding]; other site 1302863003188 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 1302863003189 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1302863003190 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1302863003191 active site 1302863003192 metal binding site [ion binding]; metal-binding site 1302863003193 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1302863003194 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1302863003195 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1302863003196 PspC domain; Region: PspC; pfam04024 1302863003197 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1302863003198 nudix motif; other site 1302863003199 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1302863003200 active site 1302863003201 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1302863003202 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 1302863003203 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1302863003204 Predicted membrane protein [Function unknown]; Region: COG4640 1302863003205 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1302863003206 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1302863003207 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1302863003208 minor groove reading motif; other site 1302863003209 helix-hairpin-helix signature motif; other site 1302863003210 substrate binding pocket [chemical binding]; other site 1302863003211 active site 1302863003212 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1302863003213 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1302863003214 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1302863003215 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 1302863003216 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1302863003217 dimerization interface [polypeptide binding]; other site 1302863003218 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1302863003219 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1302863003220 Coenzyme A binding pocket [chemical binding]; other site 1302863003221 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1302863003222 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1302863003223 Coenzyme A binding pocket [chemical binding]; other site 1302863003224 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1302863003225 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1302863003226 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1302863003227 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1302863003228 SWIM zinc finger; Region: SWIM; pfam04434 1302863003229 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 1302863003230 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1302863003231 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1302863003232 ATP binding site [chemical binding]; other site 1302863003233 putative Mg++ binding site [ion binding]; other site 1302863003234 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1302863003235 nucleotide binding region [chemical binding]; other site 1302863003236 ATP-binding site [chemical binding]; other site 1302863003237 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1302863003238 30S subunit binding site; other site 1302863003239 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1302863003240 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1302863003241 active site 1302863003242 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1302863003243 CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587 1302863003244 ATP binding site [chemical binding]; other site 1302863003245 putative Mg++ binding site [ion binding]; other site 1302863003246 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1302863003247 nucleotide binding region [chemical binding]; other site 1302863003248 ATP-binding site [chemical binding]; other site 1302863003249 Uncharacterized conserved protein [Function unknown]; Region: COG1739 1302863003250 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1302863003251 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1302863003252 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1302863003253 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1302863003254 dimer interface [polypeptide binding]; other site 1302863003255 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302863003256 catalytic residue [active] 1302863003257 hypothetical protein; Provisional; Region: PRK07252 1302863003258 general stress protein 13; Validated; Region: PRK08059 1302863003259 RNA binding site [nucleotide binding]; other site 1302863003260 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1302863003261 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1302863003262 active site 1302863003263 motif I; other site 1302863003264 motif II; other site 1302863003265 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1302863003266 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 1302863003267 active site 1302863003268 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1302863003269 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302863003270 active site 1302863003271 phosphorylation site [posttranslational modification] 1302863003272 intermolecular recognition site; other site 1302863003273 dimerization interface [polypeptide binding]; other site 1302863003274 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1302863003275 DNA binding residues [nucleotide binding] 1302863003276 dimerization interface [polypeptide binding]; other site 1302863003277 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1302863003278 Histidine kinase; Region: HisKA_3; pfam07730 1302863003279 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302863003280 ATP binding site [chemical binding]; other site 1302863003281 Mg2+ binding site [ion binding]; other site 1302863003282 G-X-G motif; other site 1302863003283 Predicted membrane protein [Function unknown]; Region: COG4758 1302863003284 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 1302863003285 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 1302863003286 putative catalytic site [active] 1302863003287 putative metal binding site [ion binding]; other site 1302863003288 putative phosphate binding site [ion binding]; other site 1302863003289 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1302863003290 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 1302863003291 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1302863003292 active site turn [active] 1302863003293 phosphorylation site [posttranslational modification] 1302863003294 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 1302863003295 HPr interaction site; other site 1302863003296 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1302863003297 active site 1302863003298 phosphorylation site [posttranslational modification] 1302863003299 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1302863003300 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1302863003301 Walker A/P-loop; other site 1302863003302 ATP binding site [chemical binding]; other site 1302863003303 Q-loop/lid; other site 1302863003304 ABC transporter signature motif; other site 1302863003305 Walker B; other site 1302863003306 D-loop; other site 1302863003307 H-loop/switch region; other site 1302863003308 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1302863003309 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1302863003310 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1302863003311 Walker A/P-loop; other site 1302863003312 ATP binding site [chemical binding]; other site 1302863003313 Q-loop/lid; other site 1302863003314 ABC transporter signature motif; other site 1302863003315 Walker B; other site 1302863003316 D-loop; other site 1302863003317 H-loop/switch region; other site 1302863003318 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1302863003319 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1302863003320 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1302863003321 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302863003322 dimer interface [polypeptide binding]; other site 1302863003323 conserved gate region; other site 1302863003324 putative PBP binding loops; other site 1302863003325 ABC-ATPase subunit interface; other site 1302863003326 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302863003327 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1302863003328 dimer interface [polypeptide binding]; other site 1302863003329 conserved gate region; other site 1302863003330 putative PBP binding loops; other site 1302863003331 ABC-ATPase subunit interface; other site 1302863003332 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1302863003333 peptide binding site [polypeptide binding]; other site 1302863003334 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1302863003335 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 1302863003336 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 1302863003337 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 1302863003338 putative active site [active] 1302863003339 catalytic site [active] 1302863003340 putative metal binding site [ion binding]; other site 1302863003341 HTH domain; Region: HTH_11; cl17392 1302863003342 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1302863003343 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1302863003344 RNA binding surface [nucleotide binding]; other site 1302863003345 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1302863003346 active site 1302863003347 uracil binding [chemical binding]; other site 1302863003348 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302863003349 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1302863003350 putative substrate translocation pore; other site 1302863003351 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1302863003352 active site 1302863003353 catalytic residues [active] 1302863003354 metal binding site [ion binding]; metal-binding site 1302863003355 Predicted membrane protein [Function unknown]; Region: COG2261 1302863003356 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1302863003357 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1302863003358 DNA polymerase III PolC; Validated; Region: polC; PRK00448 1302863003359 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 1302863003360 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 1302863003361 generic binding surface II; other site 1302863003362 generic binding surface I; other site 1302863003363 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1302863003364 active site 1302863003365 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1302863003366 active site 1302863003367 catalytic site [active] 1302863003368 substrate binding site [chemical binding]; other site 1302863003369 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 1302863003370 Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225 1302863003371 pentamer interface [polypeptide binding]; other site 1302863003372 dodecaamer interface [polypeptide binding]; other site 1302863003373 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1302863003374 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1302863003375 dimer interface [polypeptide binding]; other site 1302863003376 motif 1; other site 1302863003377 active site 1302863003378 motif 2; other site 1302863003379 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1302863003380 putative deacylase active site [active] 1302863003381 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1302863003382 active site 1302863003383 motif 3; other site 1302863003384 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1302863003385 anticodon binding site; other site 1302863003386 RIP metalloprotease RseP; Region: TIGR00054 1302863003387 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1302863003388 active site 1302863003389 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 1302863003390 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1302863003391 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1302863003392 putative substrate binding region [chemical binding]; other site 1302863003393 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1302863003394 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1302863003395 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1302863003396 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1302863003397 catalytic residue [active] 1302863003398 putative FPP diphosphate binding site; other site 1302863003399 putative FPP binding hydrophobic cleft; other site 1302863003400 dimer interface [polypeptide binding]; other site 1302863003401 putative IPP diphosphate binding site; other site 1302863003402 preprotein translocase subunit YajC; Validated; Region: yajC; PRK06531 1302863003403 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 1302863003404 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1302863003405 TPP-binding site [chemical binding]; other site 1302863003406 dimer interface [polypeptide binding]; other site 1302863003407 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1302863003408 PYR/PP interface [polypeptide binding]; other site 1302863003409 dimer interface [polypeptide binding]; other site 1302863003410 TPP binding site [chemical binding]; other site 1302863003411 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 1302863003412 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 1302863003413 SelR domain; Region: SelR; pfam01641 1302863003414 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1302863003415 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1302863003416 dimer interface [polypeptide binding]; other site 1302863003417 phosphorylation site [posttranslational modification] 1302863003418 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302863003419 ATP binding site [chemical binding]; other site 1302863003420 Mg2+ binding site [ion binding]; other site 1302863003421 G-X-G motif; other site 1302863003422 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1302863003423 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302863003424 active site 1302863003425 phosphorylation site [posttranslational modification] 1302863003426 intermolecular recognition site; other site 1302863003427 dimerization interface [polypeptide binding]; other site 1302863003428 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486 1302863003429 DNA binding site [nucleotide binding] 1302863003430 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1302863003431 synthetase active site [active] 1302863003432 NTP binding site [chemical binding]; other site 1302863003433 metal binding site [ion binding]; metal-binding site 1302863003434 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 1302863003435 ArsC family; Region: ArsC; pfam03960 1302863003436 putative ArsC-like catalytic residues; other site 1302863003437 putative TRX-like catalytic residues [active] 1302863003438 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1302863003439 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1302863003440 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1302863003441 DNA binding site [nucleotide binding] 1302863003442 active site 1302863003443 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174 1302863003444 putative ligand binding site [chemical binding]; other site 1302863003445 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1302863003446 putative NAD binding site [chemical binding]; other site 1302863003447 putative catalytic site [active] 1302863003448 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1302863003449 L-serine binding site [chemical binding]; other site 1302863003450 ACT domain interface; other site 1302863003451 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 1302863003452 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1302863003453 catalytic residue [active] 1302863003454 Predicted methyltransferases [General function prediction only]; Region: COG0313 1302863003455 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1302863003456 putative SAM binding site [chemical binding]; other site 1302863003457 putative homodimer interface [polypeptide binding]; other site 1302863003458 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 1302863003459 DNA polymerase III subunit delta'; Validated; Region: PRK07276 1302863003460 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1302863003461 thymidylate kinase; Validated; Region: tmk; PRK00698 1302863003462 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1302863003463 TMP-binding site; other site 1302863003464 ATP-binding site [chemical binding]; other site 1302863003465 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1302863003466 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1302863003467 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1302863003468 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1302863003469 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1302863003470 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1302863003471 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1302863003472 dimer interface [polypeptide binding]; other site 1302863003473 ADP-ribose binding site [chemical binding]; other site 1302863003474 active site 1302863003475 nudix motif; other site 1302863003476 metal binding site [ion binding]; metal-binding site 1302863003477 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 1302863003478 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1302863003479 Substrate binding site; other site 1302863003480 Mg++ binding site; other site 1302863003481 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1302863003482 active site 1302863003483 substrate binding site [chemical binding]; other site 1302863003484 CoA binding site [chemical binding]; other site 1302863003485 Enterocin A Immunity; Region: EntA_Immun; pfam08951 1302863003486 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 1302863003487 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 1302863003488 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 1302863003489 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 1302863003490 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 1302863003491 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 1302863003492 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 1302863003493 GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481 1302863003494 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1302863003495 putative active site [active] 1302863003496 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1302863003497 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1302863003498 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1302863003499 Protein of unknown function (DUF4059); Region: DUF4059; pfam13268 1302863003500 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1302863003501 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1302863003502 Walker A/P-loop; other site 1302863003503 ATP binding site [chemical binding]; other site 1302863003504 Q-loop/lid; other site 1302863003505 ABC transporter signature motif; other site 1302863003506 Walker B; other site 1302863003507 D-loop; other site 1302863003508 H-loop/switch region; other site 1302863003509 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302863003510 dimer interface [polypeptide binding]; other site 1302863003511 conserved gate region; other site 1302863003512 putative PBP binding loops; other site 1302863003513 ABC-ATPase subunit interface; other site 1302863003514 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1302863003515 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1302863003516 ATP binding site [chemical binding]; other site 1302863003517 Mg++ binding site [ion binding]; other site 1302863003518 motif III; other site 1302863003519 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1302863003520 nucleotide binding region [chemical binding]; other site 1302863003521 ATP-binding site [chemical binding]; other site 1302863003522 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1302863003523 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1302863003524 Mg++ binding site [ion binding]; other site 1302863003525 putative catalytic motif [active] 1302863003526 putative substrate binding site [chemical binding]; other site 1302863003527 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1302863003528 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1302863003529 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1302863003530 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 1302863003531 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 1302863003532 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 1302863003533 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 1302863003534 MraW methylase family; Region: Methyltransf_5; pfam01795 1302863003535 heat shock protein HtpX; Provisional; Region: PRK04897 1302863003536 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 1302863003537 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1302863003538 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1302863003539 S-adenosylmethionine binding site [chemical binding]; other site 1302863003540 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 1302863003541 active site 1302863003542 putative catalytic site [active] 1302863003543 DNA binding site [nucleotide binding] 1302863003544 putative phosphate binding site [ion binding]; other site 1302863003545 metal binding site A [ion binding]; metal-binding site 1302863003546 AP binding site [nucleotide binding]; other site 1302863003547 metal binding site B [ion binding]; metal-binding site 1302863003548 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 1302863003549 dimer interface [polypeptide binding]; other site 1302863003550 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1302863003551 ligand binding site [chemical binding]; other site 1302863003552 hypothetical protein; Provisional; Region: PRK13670 1302863003553 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 1302863003554 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1302863003555 S-adenosylmethionine binding site [chemical binding]; other site 1302863003556 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 1302863003557 Isochorismatase family; Region: Isochorismatase; pfam00857 1302863003558 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 1302863003559 catalytic triad [active] 1302863003560 conserved cis-peptide bond; other site 1302863003561 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1302863003562 Zn2+ binding site [ion binding]; other site 1302863003563 Mg2+ binding site [ion binding]; other site 1302863003564 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1302863003565 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1302863003566 active site 1302863003567 (T/H)XGH motif; other site 1302863003568 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 1302863003569 GTPase YqeH; Provisional; Region: PRK13796 1302863003570 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 1302863003571 GTP/Mg2+ binding site [chemical binding]; other site 1302863003572 G4 box; other site 1302863003573 G5 box; other site 1302863003574 G1 box; other site 1302863003575 Switch I region; other site 1302863003576 G2 box; other site 1302863003577 G3 box; other site 1302863003578 Switch II region; other site 1302863003579 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 1302863003580 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1302863003581 active site 1302863003582 motif I; other site 1302863003583 motif II; other site 1302863003584 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1302863003585 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1302863003586 catalytic residues [active] 1302863003587 catalytic nucleophile [active] 1302863003588 Recombinase; Region: Recombinase; pfam07508 1302863003589 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 1302863003590 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 1302863003591 Domain of unknown function (DUF4368); Region: DUF4368; pfam14287 1302863003592 Replication-relaxation; Region: Replic_Relax; pfam13814 1302863003593 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1302863003594 AAA-like domain; Region: AAA_10; pfam12846 1302863003595 Walker A motif; other site 1302863003596 ATP binding site [chemical binding]; other site 1302863003597 Walker B motif; other site 1302863003598 Protein of unknown function (DUF2806); Region: DUF2806; cl12560 1302863003599 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1302863003600 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1302863003601 catalytic residues [active] 1302863003602 catalytic nucleophile [active] 1302863003603 Presynaptic Site I dimer interface [polypeptide binding]; other site 1302863003604 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1302863003605 Synaptic Flat tetramer interface [polypeptide binding]; other site 1302863003606 Synaptic Site I dimer interface [polypeptide binding]; other site 1302863003607 DNA binding site [nucleotide binding] 1302863003608 Helix-turn-helix domain; Region: HTH_38; pfam13936 1302863003609 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1302863003610 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1302863003611 Transcriptional regulator [Transcription]; Region: LytR; COG1316 1302863003612 putative acetyltransferase YhhY; Provisional; Region: PRK10140 1302863003613 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1302863003614 Coenzyme A binding pocket [chemical binding]; other site 1302863003615 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1302863003616 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1302863003617 Protein of unknown function (DUF1361); Region: DUF1361; pfam07099 1302863003618 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1302863003619 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1302863003620 active site 1302863003621 motif I; other site 1302863003622 motif II; other site 1302863003623 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 1302863003624 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1302863003625 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1302863003626 substrate binding pocket [chemical binding]; other site 1302863003627 membrane-bound complex binding site; other site 1302863003628 hinge residues; other site 1302863003629 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1302863003630 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1302863003631 Walker A/P-loop; other site 1302863003632 ATP binding site [chemical binding]; other site 1302863003633 Q-loop/lid; other site 1302863003634 ABC transporter signature motif; other site 1302863003635 Walker B; other site 1302863003636 D-loop; other site 1302863003637 H-loop/switch region; other site 1302863003638 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302863003639 dimer interface [polypeptide binding]; other site 1302863003640 conserved gate region; other site 1302863003641 putative PBP binding loops; other site 1302863003642 ABC-ATPase subunit interface; other site 1302863003643 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1302863003644 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302863003645 dimer interface [polypeptide binding]; other site 1302863003646 conserved gate region; other site 1302863003647 putative PBP binding loops; other site 1302863003648 ABC-ATPase subunit interface; other site 1302863003649 L-lactate oxidase; Region: L_lactate_ox; TIGR02708 1302863003650 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 1302863003651 teramer interface [polypeptide binding]; other site 1302863003652 active site 1302863003653 FMN binding site [chemical binding]; other site 1302863003654 catalytic residues [active] 1302863003655 Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253 1302863003656 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1302863003657 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1302863003658 active site 1302863003659 catalytic tetrad [active] 1302863003660 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1302863003661 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1302863003662 active site 1302863003663 dimer interface [polypeptide binding]; other site 1302863003664 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1302863003665 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1302863003666 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1302863003667 PhoU domain; Region: PhoU; pfam01895 1302863003668 PhoU domain; Region: PhoU; pfam01895 1302863003669 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 1302863003670 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 1302863003671 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1302863003672 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1302863003673 cell division protein GpsB; Provisional; Region: PRK14127 1302863003674 DivIVA domain; Region: DivI1A_domain; TIGR03544 1302863003675 hypothetical protein; Provisional; Region: PRK13660 1302863003676 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 1302863003677 Transglycosylase; Region: Transgly; pfam00912 1302863003678 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1302863003679 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1302863003680 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1302863003681 Homeodomain-like domain; Region: HTH_23; cl17451 1302863003682 Transposase; Region: HTH_Tnp_1; cl17663 1302863003683 Integrase core domain; Region: rve; pfam00665 1302863003684 Integrase core domain; Region: rve_2; pfam13333 1302863003685 potential frameshift: common BLAST hit: gi|325977913|ref|YP_004287629.1| phage integrase family site specific recombinase 1302863003686 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1302863003687 non-specific DNA binding site [nucleotide binding]; other site 1302863003688 salt bridge; other site 1302863003689 sequence-specific DNA binding site [nucleotide binding]; other site 1302863003690 Replication initiation factor; Region: Rep_trans; pfam02486 1302863003691 RelB antitoxin; Region: RelB; cl01171 1302863003692 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 1302863003693 GTPase CgtA; Reviewed; Region: obgE; PRK12297 1302863003694 GTP1/OBG; Region: GTP1_OBG; pfam01018 1302863003695 Obg GTPase; Region: Obg; cd01898 1302863003696 G1 box; other site 1302863003697 GTP/Mg2+ binding site [chemical binding]; other site 1302863003698 Switch I region; other site 1302863003699 G2 box; other site 1302863003700 G3 box; other site 1302863003701 Switch II region; other site 1302863003702 G4 box; other site 1302863003703 G5 box; other site 1302863003704 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 1302863003705 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 1302863003706 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1302863003707 active site 1302863003708 substrate binding site [chemical binding]; other site 1302863003709 metal binding site [ion binding]; metal-binding site 1302863003710 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 1302863003711 YbbR-like protein; Region: YbbR; pfam07949 1302863003712 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1302863003713 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1302863003714 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 1302863003715 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1302863003716 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 1302863003717 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 1302863003718 catalytic triad [active] 1302863003719 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1302863003720 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1302863003721 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1302863003722 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1302863003723 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1302863003724 active site 1302863003725 dimer interface [polypeptide binding]; other site 1302863003726 motif 1; other site 1302863003727 motif 2; other site 1302863003728 motif 3; other site 1302863003729 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1302863003730 anticodon binding site; other site 1302863003731 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 1302863003732 active site 1302863003733 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1302863003734 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 1302863003735 putative ADP-binding pocket [chemical binding]; other site 1302863003736 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1302863003737 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1302863003738 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 1302863003739 Family description; Region: UvrD_C_2; pfam13538 1302863003740 Family description; Region: UvrD_C_2; pfam13538 1302863003741 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1302863003742 ATP-dependent nuclease subunit B; Region: rexB_recomb; TIGR02774 1302863003743 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 1302863003744 elongation factor Tu; Reviewed; Region: PRK00049 1302863003745 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1302863003746 G1 box; other site 1302863003747 GEF interaction site [polypeptide binding]; other site 1302863003748 GTP/Mg2+ binding site [chemical binding]; other site 1302863003749 Switch I region; other site 1302863003750 G2 box; other site 1302863003751 G3 box; other site 1302863003752 Switch II region; other site 1302863003753 G4 box; other site 1302863003754 G5 box; other site 1302863003755 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1302863003756 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1302863003757 Antibiotic Binding Site [chemical binding]; other site 1302863003758 Sigma factor regulator C-terminal; Region: Sigma_reg_C; pfam13791 1302863003759 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1302863003760 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1302863003761 DNA binding residues [nucleotide binding] 1302863003762 Predicted membrane protein [Function unknown]; Region: COG3152 1302863003763 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1302863003764 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1302863003765 Competence protein; Region: Competence; pfam03772 1302863003766 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 1302863003767 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1302863003768 SLBB domain; Region: SLBB; pfam10531 1302863003769 comEA protein; Region: comE; TIGR01259 1302863003770 Helix-hairpin-helix motif; Region: HHH; pfam00633 1302863003771 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1302863003772 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1302863003773 putative acyl-acceptor binding pocket; other site 1302863003774 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1302863003775 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 1302863003776 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1302863003777 motif II; other site 1302863003778 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1302863003779 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1302863003780 S-adenosylmethionine binding site [chemical binding]; other site 1302863003781 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1302863003782 GIY-YIG motif/motif A; other site 1302863003783 putative active site [active] 1302863003784 putative metal binding site [ion binding]; other site 1302863003785 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 1302863003786 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1302863003787 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 1302863003788 putative substrate binding site [chemical binding]; other site 1302863003789 putative ATP binding site [chemical binding]; other site 1302863003790 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 1302863003791 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 1302863003792 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 1302863003793 catalytic residues [active] 1302863003794 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1302863003795 PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611 1302863003796 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1302863003797 active site 1302863003798 P-loop; other site 1302863003799 phosphorylation site [posttranslational modification] 1302863003800 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1302863003801 active site 1302863003802 phosphorylation site [posttranslational modification] 1302863003803 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1302863003804 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1302863003805 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1302863003806 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1302863003807 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1302863003808 ATP binding site [chemical binding]; other site 1302863003809 Mg++ binding site [ion binding]; other site 1302863003810 motif III; other site 1302863003811 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1302863003812 nucleotide binding region [chemical binding]; other site 1302863003813 ATP-binding site [chemical binding]; other site 1302863003814 pyruvate kinase; Provisional; Region: PRK05826 1302863003815 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1302863003816 domain interfaces; other site 1302863003817 active site 1302863003818 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1302863003819 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1302863003820 active site 1302863003821 ADP/pyrophosphate binding site [chemical binding]; other site 1302863003822 dimerization interface [polypeptide binding]; other site 1302863003823 allosteric effector site; other site 1302863003824 fructose-1,6-bisphosphate binding site; other site 1302863003825 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279 1302863003826 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 1302863003827 active site 1302863003828 PHP Thumb interface [polypeptide binding]; other site 1302863003829 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1302863003830 generic binding surface II; other site 1302863003831 generic binding surface I; other site 1302863003832 catabolite control protein A; Region: ccpA; TIGR01481 1302863003833 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1302863003834 DNA binding site [nucleotide binding] 1302863003835 domain linker motif; other site 1302863003836 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 1302863003837 dimerization interface [polypeptide binding]; other site 1302863003838 effector binding site; other site 1302863003839 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1302863003840 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1302863003841 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 1302863003842 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 1302863003843 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1302863003844 active site 1302863003845 Predicted membrane protein [Function unknown]; Region: COG2035 1302863003846 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1302863003847 putative deacylase active site [active] 1302863003848 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1302863003849 catalytic core [active] 1302863003850 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1302863003851 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1302863003852 dimer interface [polypeptide binding]; other site 1302863003853 putative anticodon binding site; other site 1302863003854 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1302863003855 motif 1; other site 1302863003856 active site 1302863003857 motif 2; other site 1302863003858 motif 3; other site 1302863003859 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1302863003860 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1302863003861 FtsX-like permease family; Region: FtsX; pfam02687 1302863003862 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1302863003863 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1302863003864 Walker A/P-loop; other site 1302863003865 ATP binding site [chemical binding]; other site 1302863003866 Q-loop/lid; other site 1302863003867 ABC transporter signature motif; other site 1302863003868 Walker B; other site 1302863003869 D-loop; other site 1302863003870 H-loop/switch region; other site 1302863003871 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1302863003872 HlyD family secretion protein; Region: HlyD_3; pfam13437 1302863003873 glutathione reductase; Validated; Region: PRK06116 1302863003874 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1302863003875 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1302863003876 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1302863003877 Integrase core domain; Region: rve; pfam00665 1302863003878 Integrase core domain; Region: rve_2; pfam13333 1302863003879 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1302863003880 Homeodomain-like domain; Region: HTH_23; cl17451 1302863003881 Transposase; Region: HTH_Tnp_1; cl17663 1302863003882 BioY family; Region: BioY; pfam02632 1302863003883 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 1302863003884 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1302863003885 Peptidase family U32; Region: Peptidase_U32; pfam01136 1302863003886 Peptidase family C69; Region: Peptidase_C69; cl17793 1302863003887 tellurite resistance protein TehB; Provisional; Region: PRK12335 1302863003888 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 1302863003889 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1302863003890 S-adenosylmethionine binding site [chemical binding]; other site 1302863003891 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1302863003892 SmpB-tmRNA interface; other site 1302863003893 ribonuclease R; Region: RNase_R; TIGR02063 1302863003894 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1302863003895 RNB domain; Region: RNB; pfam00773 1302863003896 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1302863003897 RNA binding site [nucleotide binding]; other site 1302863003898 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 1302863003899 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1302863003900 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302863003901 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1302863003902 putative substrate translocation pore; other site 1302863003903 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1302863003904 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1302863003905 CoA-binding site [chemical binding]; other site 1302863003906 ATP-binding [chemical binding]; other site 1302863003907 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1302863003908 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1302863003909 DNA binding site [nucleotide binding] 1302863003910 catalytic residue [active] 1302863003911 H2TH interface [polypeptide binding]; other site 1302863003912 putative catalytic residues [active] 1302863003913 turnover-facilitating residue; other site 1302863003914 intercalation triad [nucleotide binding]; other site 1302863003915 8OG recognition residue [nucleotide binding]; other site 1302863003916 putative reading head residues; other site 1302863003917 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1302863003918 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1302863003919 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1302863003920 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1302863003921 Coenzyme A binding pocket [chemical binding]; other site 1302863003922 DinB superfamily; Region: DinB_2; pfam12867 1302863003923 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 1302863003924 nudix motif; other site 1302863003925 GTPase Era; Reviewed; Region: era; PRK00089 1302863003926 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1302863003927 G1 box; other site 1302863003928 GTP/Mg2+ binding site [chemical binding]; other site 1302863003929 Switch I region; other site 1302863003930 G2 box; other site 1302863003931 Switch II region; other site 1302863003932 G3 box; other site 1302863003933 G4 box; other site 1302863003934 G5 box; other site 1302863003935 KH domain; Region: KH_2; pfam07650 1302863003936 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1302863003937 metal-binding heat shock protein; Provisional; Region: PRK00016 1302863003938 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1302863003939 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1302863003940 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 1302863003941 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 1302863003942 hexamer interface [polypeptide binding]; other site 1302863003943 ligand binding site [chemical binding]; other site 1302863003944 putative active site [active] 1302863003945 NAD(P) binding site [chemical binding]; other site 1302863003946 Protein of unknown function (DUF3267); Region: DUF3267; pfam11667 1302863003947 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 1302863003948 PspC domain; Region: PspC; pfam04024 1302863003949 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1302863003950 non-specific DNA binding site [nucleotide binding]; other site 1302863003951 salt bridge; other site 1302863003952 sequence-specific DNA binding site [nucleotide binding]; other site 1302863003953 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1302863003954 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1302863003955 motif 1; other site 1302863003956 active site 1302863003957 motif 2; other site 1302863003958 motif 3; other site 1302863003959 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1302863003960 DHHA1 domain; Region: DHHA1; pfam02272 1302863003961 Tubby C 2; Region: Tub_2; cl02043 1302863003962 foldase protein PrsA; Reviewed; Region: prsA; PRK01326 1302863003963 SurA N-terminal domain; Region: SurA_N_3; cl07813 1302863003964 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 1302863003965 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 1302863003966 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1302863003967 S-adenosylmethionine binding site [chemical binding]; other site 1302863003968 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 1302863003969 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 1302863003970 active site 1302863003971 Zn binding site [ion binding]; other site 1302863003972 Competence protein CoiA-like family; Region: CoiA; cl11541 1302863003973 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302863003974 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1302863003975 putative substrate translocation pore; other site 1302863003976 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1302863003977 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1302863003978 Domain of unknown function (DUF1958); Region: DUF1958; pfam09211 1302863003979 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1302863003980 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1302863003981 active site 1302863003982 trimer interface [polypeptide binding]; other site 1302863003983 allosteric site; other site 1302863003984 active site lid [active] 1302863003985 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1302863003986 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1302863003987 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1302863003988 Arginine repressor [Transcription]; Region: ArgR; COG1438 1302863003989 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1302863003990 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1302863003991 hypothetical protein; Provisional; Region: PRK07205 1302863003992 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 1302863003993 active site 1302863003994 metal binding site [ion binding]; metal-binding site 1302863003995 Predicted membrane protein [Function unknown]; Region: COG1288 1302863003996 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1302863003997 carbamate kinase; Reviewed; Region: PRK12686 1302863003998 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1302863003999 putative substrate binding site [chemical binding]; other site 1302863004000 nucleotide binding site [chemical binding]; other site 1302863004001 nucleotide binding site [chemical binding]; other site 1302863004002 homodimer interface [polypeptide binding]; other site 1302863004003 ornithine carbamoyltransferase; Validated; Region: PRK02102 1302863004004 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1302863004005 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1302863004006 arginine deiminase; Provisional; Region: PRK01388 1302863004007 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1302863004008 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1302863004009 ligand binding site [chemical binding]; other site 1302863004010 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1302863004011 non-specific DNA interactions [nucleotide binding]; other site 1302863004012 DNA binding site [nucleotide binding] 1302863004013 sequence specific DNA binding site [nucleotide binding]; other site 1302863004014 putative cAMP binding site [chemical binding]; other site 1302863004015 Protein of unknown function (DUF1648); Region: DUF1648; pfam07853 1302863004016 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1302863004017 dimerization interface [polypeptide binding]; other site 1302863004018 putative DNA binding site [nucleotide binding]; other site 1302863004019 putative Zn2+ binding site [ion binding]; other site 1302863004020 Putative membrane peptidase family (DUF2324); Region: DUF2324; pfam10086 1302863004021 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 1302863004022 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1302863004023 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1302863004024 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1302863004025 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1302863004026 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1302863004027 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 1302863004028 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1302863004029 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 1302863004030 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 1302863004031 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1302863004032 accessory Sec system translocase SecA2; Region: secA2; TIGR03714 1302863004033 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1302863004034 ATP binding site [chemical binding]; other site 1302863004035 putative Mg++ binding site [ion binding]; other site 1302863004036 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1302863004037 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 1302863004038 nucleotide binding region [chemical binding]; other site 1302863004039 ATP-binding site [chemical binding]; other site 1302863004040 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 1302863004041 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 1302863004042 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 1302863004043 SecY translocase; Region: SecY; pfam00344 1302863004044 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1302863004045 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 1302863004046 Ligand binding site; other site 1302863004047 metal-binding site 1302863004048 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 1302863004049 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1302863004050 FeS/SAM binding site; other site 1302863004051 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1302863004052 Domain of unknown function DUF21; Region: DUF21; pfam01595 1302863004053 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1302863004054 Transporter associated domain; Region: CorC_HlyC; pfam03471 1302863004055 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270 1302863004056 active site 1302863004057 metal-binding site [ion binding] 1302863004058 nucleotide-binding site [chemical binding]; other site 1302863004059 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1302863004060 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1302863004061 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 1302863004062 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 1302863004063 nudix motif; other site 1302863004064 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1302863004065 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1302863004066 active site 1302863004067 HIGH motif; other site 1302863004068 nucleotide binding site [chemical binding]; other site 1302863004069 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1302863004070 active site 1302863004071 KMSKS motif; other site 1302863004072 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1302863004073 tRNA binding surface [nucleotide binding]; other site 1302863004074 anticodon binding site; other site 1302863004075 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1302863004076 DivIVA protein; Region: DivIVA; pfam05103 1302863004077 DivIVA domain; Region: DivI1A_domain; TIGR03544 1302863004078 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 1302863004079 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1302863004080 RNA binding surface [nucleotide binding]; other site 1302863004081 YGGT family; Region: YGGT; pfam02325 1302863004082 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 1302863004083 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1302863004084 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1302863004085 catalytic residue [active] 1302863004086 cell division protein FtsZ; Validated; Region: PRK09330 1302863004087 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1302863004088 nucleotide binding site [chemical binding]; other site 1302863004089 SulA interaction site; other site 1302863004090 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 1302863004091 Cell division protein FtsA; Region: FtsA; smart00842 1302863004092 Cell division protein FtsA; Region: FtsA; pfam14450 1302863004093 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 1302863004094 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1302863004095 Cell division protein FtsQ; Region: FtsQ; pfam03799 1302863004096 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1302863004097 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1302863004098 homodimer interface [polypeptide binding]; other site 1302863004099 active site 1302863004100 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 1302863004101 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 1302863004102 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1302863004103 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1302863004104 Protein of unknown function (DUF3165); Region: DUF3165; pfam11364 1302863004105 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1302863004106 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1302863004107 G1 box; other site 1302863004108 putative GEF interaction site [polypeptide binding]; other site 1302863004109 GTP/Mg2+ binding site [chemical binding]; other site 1302863004110 Switch I region; other site 1302863004111 G2 box; other site 1302863004112 G3 box; other site 1302863004113 Switch II region; other site 1302863004114 G4 box; other site 1302863004115 G5 box; other site 1302863004116 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1302863004117 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1302863004118 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1302863004119 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1302863004120 RNA binding surface [nucleotide binding]; other site 1302863004121 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1302863004122 active site 1302863004123 uracil binding [chemical binding]; other site 1302863004124 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1302863004125 active site residue [active] 1302863004126 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 1302863004127 potential frameshift: common BLAST hit: gi|387880446|ref|YP_006310749.1| transposase 1302863004128 Integrase core domain; Region: rve; pfam00665 1302863004129 Integrase core domain; Region: rve_2; pfam13333 1302863004130 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1302863004131 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1302863004132 dimerization interface [polypeptide binding]; other site 1302863004133 DPS ferroxidase diiron center [ion binding]; other site 1302863004134 ion pore; other site 1302863004135 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1302863004136 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1302863004137 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1302863004138 substrate binding site [chemical binding]; other site 1302863004139 active site 1302863004140 catalytic residues [active] 1302863004141 heterodimer interface [polypeptide binding]; other site 1302863004142 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1302863004143 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1302863004144 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302863004145 catalytic residue [active] 1302863004146 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1302863004147 active site 1302863004148 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1302863004149 active site 1302863004150 ribulose/triose binding site [chemical binding]; other site 1302863004151 phosphate binding site [ion binding]; other site 1302863004152 substrate (anthranilate) binding pocket [chemical binding]; other site 1302863004153 product (indole) binding pocket [chemical binding]; other site 1302863004154 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1302863004155 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1302863004156 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1302863004157 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1302863004158 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1302863004159 glutamine binding [chemical binding]; other site 1302863004160 catalytic triad [active] 1302863004161 anthranilate synthase component I; Provisional; Region: PRK13570 1302863004162 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1302863004163 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1302863004164 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1302863004165 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1302863004166 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302863004167 catalytic residue [active] 1302863004168 VanZ like family; Region: VanZ; pfam04892 1302863004169 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 1302863004170 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1302863004171 FeS/SAM binding site; other site 1302863004172 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 1302863004173 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 1302863004174 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1302863004175 protein binding site [polypeptide binding]; other site 1302863004176 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1302863004177 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1302863004178 active site 1302863004179 (T/H)XGH motif; other site 1302863004180 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 1302863004181 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1302863004182 S-adenosylmethionine binding site [chemical binding]; other site 1302863004183 Probable N6-adenine methyltransferase; Region: N6-adenineMlase; pfam10237 1302863004184 hypothetical protein; Validated; Region: PRK00041 1302863004185 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1302863004186 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1302863004187 RNA binding surface [nucleotide binding]; other site 1302863004188 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 1302863004189 active site 1302863004190 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 1302863004191 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 1302863004192 site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436 1302863004193 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1302863004194 DNA binding site [nucleotide binding] 1302863004195 Int/Topo IB signature motif; other site 1302863004196 active site 1302863004197 catalytic residues [active] 1302863004198 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 1302863004199 FOG: CBS domain [General function prediction only]; Region: COG0517 1302863004200 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1302863004201 active site 1302863004202 metal binding site [ion binding]; metal-binding site 1302863004203 homotetramer interface [polypeptide binding]; other site 1302863004204 putative deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein; Reviewed; Region: PRK02491 1302863004205 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1302863004206 active site 1302863004207 dimerization interface [polypeptide binding]; other site 1302863004208 glutamate racemase; Provisional; Region: PRK00865 1302863004209 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 1302863004210 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 1302863004211 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1302863004212 active site 1302863004213 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1302863004214 substrate binding site [chemical binding]; other site 1302863004215 catalytic residues [active] 1302863004216 dimer interface [polypeptide binding]; other site 1302863004217 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1302863004218 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1302863004219 active site 1302863004220 HIGH motif; other site 1302863004221 nucleotide binding site [chemical binding]; other site 1302863004222 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1302863004223 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1302863004224 active site 1302863004225 KMSKS motif; other site 1302863004226 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1302863004227 tRNA binding surface [nucleotide binding]; other site 1302863004228 anticodon binding site; other site 1302863004229 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1302863004230 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1302863004231 Domain of unknown function (DUF1912); Region: DUF1912; pfam08930 1302863004232 Uncharacterized conserved protein [Function unknown]; Region: COG2461 1302863004233 Family of unknown function (DUF438); Region: DUF438; pfam04282 1302863004234 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 1302863004235 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1302863004236 putative active site [active] 1302863004237 heme pocket [chemical binding]; other site 1302863004238 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 1302863004239 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 1302863004240 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1302863004241 FMN binding site [chemical binding]; other site 1302863004242 substrate binding site [chemical binding]; other site 1302863004243 putative catalytic residue [active] 1302863004244 potential frameshift: common BLAST hit: gi|405761177|ref|YP_006701773.1| bacitracin transport ATP-binding protein bcrA 1302863004245 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1302863004246 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1302863004247 non-specific DNA binding site [nucleotide binding]; other site 1302863004248 salt bridge; other site 1302863004249 sequence-specific DNA binding site [nucleotide binding]; other site 1302863004250 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 1302863004251 TRAM domain; Region: TRAM; pfam01938 1302863004252 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 1302863004253 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1302863004254 S-adenosylmethionine binding site [chemical binding]; other site 1302863004255 recombination regulator RecX; Provisional; Region: recX; PRK14135 1302863004256 hypothetical protein; Provisional; Region: PRK13662 1302863004257 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 1302863004258 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1302863004259 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1302863004260 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1302863004261 dimerization interface [polypeptide binding]; other site 1302863004262 putative Zn2+ binding site [ion binding]; other site 1302863004263 putative DNA binding site [nucleotide binding]; other site 1302863004264 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1302863004265 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1302863004266 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1302863004267 ABC transporter; Region: ABC_tran_2; pfam12848 1302863004268 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1302863004269 FOG: CBS domain [General function prediction only]; Region: COG0517 1302863004270 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 1302863004271 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 1302863004272 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179 1302863004273 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1302863004274 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1302863004275 homodimer interface [polypeptide binding]; other site 1302863004276 NADP binding site [chemical binding]; other site 1302863004277 substrate binding site [chemical binding]; other site 1302863004278 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 1302863004279 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1302863004280 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1302863004281 Walker A motif; other site 1302863004282 ATP binding site [chemical binding]; other site 1302863004283 Walker B motif; other site 1302863004284 arginine finger; other site 1302863004285 UvrB/uvrC motif; Region: UVR; pfam02151 1302863004286 endopeptidase Clp ATP-binding regulatory subunit (clpX); Region: clpX; TIGR00382 1302863004287 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1302863004288 Walker A motif; other site 1302863004289 ATP binding site [chemical binding]; other site 1302863004290 Walker B motif; other site 1302863004291 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1302863004292 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1302863004293 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1302863004294 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1302863004295 S-adenosylmethionine binding site [chemical binding]; other site 1302863004296 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 1302863004297 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1302863004298 active site 1302863004299 DNA binding site [nucleotide binding] 1302863004300 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1302863004301 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 1302863004302 active site 1302863004303 Predicted membrane protein [Function unknown]; Region: COG3601 1302863004304 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1302863004305 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1302863004306 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1302863004307 TrkA-N domain; Region: TrkA_N; pfam02254 1302863004308 TrkA-C domain; Region: TrkA_C; pfam02080 1302863004309 TrkA-N domain; Region: TrkA_N; pfam02254 1302863004310 TrkA-C domain; Region: TrkA_C; pfam02080 1302863004311 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1302863004312 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1302863004313 Protein of unknown function, DUF600; Region: DUF600; cl04640 1302863004314 Domain of unknown function (DUF1910); Region: DUF1910; pfam08928 1302863004315 Domain of unknown function (DUF1911); Region: DUF1911; pfam08929 1302863004316 GAD-like domain; Region: GAD-like; pfam08887 1302863004317 Domain of unknown function (DUF1851); Region: DUF1851; pfam08906 1302863004318 Domain of unknown function (DUF1910); Region: DUF1910; pfam08928 1302863004319 Domain of unknown function (DUF1911); Region: DUF1911; pfam08929 1302863004320 LXG domain of WXG superfamily; Region: LXG; pfam04740 1302863004321 Domain of unknown function (DUF4176); Region: DUF4176; cl01867 1302863004322 hypothetical protein; Provisional; Region: PRK00106 1302863004323 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1302863004324 Zn2+ binding site [ion binding]; other site 1302863004325 Mg2+ binding site [ion binding]; other site 1302863004326 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1302863004327 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1302863004328 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302863004329 active site 1302863004330 phosphorylation site [posttranslational modification] 1302863004331 intermolecular recognition site; other site 1302863004332 dimerization interface [polypeptide binding]; other site 1302863004333 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1302863004334 DNA binding site [nucleotide binding] 1302863004335 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1302863004336 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1302863004337 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1302863004338 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1302863004339 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1302863004340 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1302863004341 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1302863004342 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 1302863004343 Zn2+ binding site [ion binding]; other site 1302863004344 Mg2+ binding site [ion binding]; other site 1302863004345 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1302863004346 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1302863004347 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1302863004348 acylphosphatase; Provisional; Region: PRK14434 1302863004349 OxaA-like protein precursor; Provisional; Region: PRK02463 1302863004350 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1302863004351 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 1302863004352 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 1302863004353 active site 1302863004354 FMN binding site [chemical binding]; other site 1302863004355 substrate binding site [chemical binding]; other site 1302863004356 catalytic residues [active] 1302863004357 homodimer interface [polypeptide binding]; other site 1302863004358 glutamate dehydrogenase; Provisional; Region: PRK09414 1302863004359 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1302863004360 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1302863004361 NAD(P) binding site [chemical binding]; other site 1302863004362 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1302863004363 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1302863004364 catalytic core [active] 1302863004365 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 1302863004366 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1302863004367 catalytic core [active] 1302863004368 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1302863004369 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 1302863004370 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 1302863004371 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1302863004372 active site 1302863004373 Zn binding site [ion binding]; other site 1302863004374 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 1302863004375 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1302863004376 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1302863004377 Coenzyme A binding pocket [chemical binding]; other site 1302863004378 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 1302863004379 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 1302863004380 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1302863004381 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1302863004382 Walker A motif; other site 1302863004383 ATP binding site [chemical binding]; other site 1302863004384 Walker B motif; other site 1302863004385 arginine finger; other site 1302863004386 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1302863004387 sequence-specific DNA binding site [nucleotide binding]; other site 1302863004388 salt bridge; other site 1302863004389 Replication initiation factor; Region: Rep_trans; pfam02486 1302863004390 Omega Transcriptional Repressor; Region: Omega_Repress; pfam07764 1302863004391 23S rRNA methylase leader peptide (ErmC); Region: ErmC; pfam06308 1302863004392 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 1302863004393 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1302863004394 S-adenosylmethionine binding site [chemical binding]; other site 1302863004395 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 1302863004396 Transposase; Region: DDE_Tnp_ISL3; pfam01610 1302863004397 Antirestriction protein (ArdA); Region: ArdA; pfam07275 1302863004398 TcpE family; Region: TcpE; pfam12648 1302863004399 AAA-like domain; Region: AAA_10; pfam12846 1302863004400 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 1302863004401 Haemolysin-III related; Region: HlyIII; cl03831 1302863004402 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1302863004403 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1302863004404 catalytic residue [active] 1302863004405 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1302863004406 NlpC/P60 family; Region: NLPC_P60; pfam00877 1302863004407 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 1302863004408 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 1302863004409 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 1302863004410 G1 box; other site 1302863004411 putative GEF interaction site [polypeptide binding]; other site 1302863004412 GTP/Mg2+ binding site [chemical binding]; other site 1302863004413 Switch I region; other site 1302863004414 G2 box; other site 1302863004415 G3 box; other site 1302863004416 Switch II region; other site 1302863004417 G4 box; other site 1302863004418 G5 box; other site 1302863004419 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 1302863004420 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 1302863004421 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 1302863004422 Cysteine-rich KTR; Region: Cys_rich_KTR; pfam14205 1302863004423 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1302863004424 non-specific DNA binding site [nucleotide binding]; other site 1302863004425 salt bridge; other site 1302863004426 sequence-specific DNA binding site [nucleotide binding]; other site 1302863004427 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1302863004428 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1302863004429 DNA binding residues [nucleotide binding] 1302863004430 Helix-turn-helix domain; Region: HTH_16; pfam12645 1302863004431 Excisionase from transposon Tn916; Region: Tn916-Xis; pfam09035 1302863004432 DNA binding domain of tn916 integrase; Region: Integrase_DNA; pfam02920 1302863004433 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 1302863004434 Int/Topo IB signature motif; other site 1302863004435 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1302863004436 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1302863004437 S-adenosylmethionine binding site [chemical binding]; other site 1302863004438 HNH endonuclease; Region: HNH; pfam01844 1302863004439 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1302863004440 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1302863004441 intersubunit interface [polypeptide binding]; other site 1302863004442 active site 1302863004443 zinc binding site [ion binding]; other site 1302863004444 Na+ binding site [ion binding]; other site 1302863004445 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1302863004446 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1302863004447 translation initiation factor IF-2; Region: IF-2; TIGR00487 1302863004448 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1302863004449 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1302863004450 G1 box; other site 1302863004451 putative GEF interaction site [polypeptide binding]; other site 1302863004452 GTP/Mg2+ binding site [chemical binding]; other site 1302863004453 Switch I region; other site 1302863004454 G2 box; other site 1302863004455 G3 box; other site 1302863004456 Switch II region; other site 1302863004457 G4 box; other site 1302863004458 G5 box; other site 1302863004459 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1302863004460 Translation-initiation factor 2; Region: IF-2; pfam11987 1302863004461 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1302863004462 hypothetical protein; Provisional; Region: PRK07283 1302863004463 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 1302863004464 putative RNA binding cleft [nucleotide binding]; other site 1302863004465 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 1302863004466 NusA N-terminal domain; Region: NusA_N; pfam08529 1302863004467 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1302863004468 RNA binding site [nucleotide binding]; other site 1302863004469 homodimer interface [polypeptide binding]; other site 1302863004470 NusA-like KH domain; Region: KH_5; pfam13184 1302863004471 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1302863004472 G-X-X-G motif; other site 1302863004473 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1302863004474 Sm and related proteins; Region: Sm_like; cl00259 1302863004475 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1302863004476 putative oligomer interface [polypeptide binding]; other site 1302863004477 putative RNA binding site [nucleotide binding]; other site 1302863004478 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1302863004479 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1302863004480 active site 1302863004481 ATP binding site [chemical binding]; other site 1302863004482 substrate binding site [chemical binding]; other site 1302863004483 activation loop (A-loop); other site 1302863004484 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 1302863004485 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1302863004486 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1302863004487 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 1302863004488 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1302863004489 active site 1302863004490 16S rRNA methyltransferase B; Provisional; Region: PRK14902 1302863004491 NusB family; Region: NusB; pfam01029 1302863004492 putative RNA binding site [nucleotide binding]; other site 1302863004493 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1302863004494 S-adenosylmethionine binding site [chemical binding]; other site 1302863004495 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1302863004496 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1302863004497 putative active site [active] 1302863004498 substrate binding site [chemical binding]; other site 1302863004499 putative cosubstrate binding site; other site 1302863004500 catalytic site [active] 1302863004501 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1302863004502 substrate binding site [chemical binding]; other site 1302863004503 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 1302863004504 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1302863004505 ATP binding site [chemical binding]; other site 1302863004506 putative Mg++ binding site [ion binding]; other site 1302863004507 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1302863004508 ATP-binding site [chemical binding]; other site 1302863004509 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 1302863004510 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1302863004511 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1302863004512 catalytic site [active] 1302863004513 G-X2-G-X-G-K; other site 1302863004514 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 1302863004515 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 1302863004516 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 1302863004517 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 1302863004518 classical (c) SDRs; Region: SDR_c; cd05233 1302863004519 NAD(P) binding site [chemical binding]; other site 1302863004520 active site 1302863004521 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 1302863004522 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 1302863004523 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1302863004524 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 1302863004525 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1302863004526 Coenzyme A binding pocket [chemical binding]; other site 1302863004527 amino acid transporter; Region: 2A0306; TIGR00909 1302863004528 FtsX-like permease family; Region: FtsX; pfam02687 1302863004529 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1302863004530 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1302863004531 Walker A/P-loop; other site 1302863004532 ATP binding site [chemical binding]; other site 1302863004533 Q-loop/lid; other site 1302863004534 ABC transporter signature motif; other site 1302863004535 Walker B; other site 1302863004536 D-loop; other site 1302863004537 H-loop/switch region; other site 1302863004538 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 1302863004539 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 1302863004540 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1302863004541 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1302863004542 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1302863004543 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 1302863004544 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 1302863004545 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 1302863004546 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 1302863004547 G5 domain; Region: G5; pfam07501 1302863004548 NrdI Flavodoxin like; Region: Flavodoxin_NdrI; pfam07972 1302863004549 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1302863004550 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1302863004551 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 1302863004552 LytTr DNA-binding domain; Region: LytTR; smart00850 1302863004553 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1302863004554 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1302863004555 Walker A/P-loop; other site 1302863004556 ATP binding site [chemical binding]; other site 1302863004557 Q-loop/lid; other site 1302863004558 ABC transporter signature motif; other site 1302863004559 Walker B; other site 1302863004560 D-loop; other site 1302863004561 H-loop/switch region; other site 1302863004562 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 1302863004563 FtsX-like permease family; Region: FtsX; pfam02687 1302863004564 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1302863004565 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1302863004566 Walker A/P-loop; other site 1302863004567 ATP binding site [chemical binding]; other site 1302863004568 Q-loop/lid; other site 1302863004569 ABC transporter signature motif; other site 1302863004570 Walker B; other site 1302863004571 D-loop; other site 1302863004572 H-loop/switch region; other site 1302863004573 TraX protein; Region: TraX; cl05434 1302863004574 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1302863004575 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302863004576 ATP binding site [chemical binding]; other site 1302863004577 Mg2+ binding site [ion binding]; other site 1302863004578 G-X-G motif; other site 1302863004579 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1302863004580 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302863004581 active site 1302863004582 phosphorylation site [posttranslational modification] 1302863004583 intermolecular recognition site; other site 1302863004584 dimerization interface [polypeptide binding]; other site 1302863004585 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1302863004586 DNA binding site [nucleotide binding] 1302863004587 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 1302863004588 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 1302863004589 nucleophilic elbow; other site 1302863004590 catalytic triad; other site 1302863004591 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1302863004592 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 1302863004593 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1302863004594 active site 1302863004595 HIGH motif; other site 1302863004596 KMSKS motif; other site 1302863004597 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1302863004598 tRNA binding surface [nucleotide binding]; other site 1302863004599 anticodon binding site; other site 1302863004600 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1302863004601 dimer interface [polypeptide binding]; other site 1302863004602 putative tRNA-binding site [nucleotide binding]; other site 1302863004603 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1302863004604 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1302863004605 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1302863004606 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1302863004607 Walker A/P-loop; other site 1302863004608 ATP binding site [chemical binding]; other site 1302863004609 Q-loop/lid; other site 1302863004610 ABC transporter signature motif; other site 1302863004611 Walker B; other site 1302863004612 D-loop; other site 1302863004613 H-loop/switch region; other site 1302863004614 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 1302863004615 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1302863004616 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1302863004617 Walker A/P-loop; other site 1302863004618 ATP binding site [chemical binding]; other site 1302863004619 Q-loop/lid; other site 1302863004620 ABC transporter signature motif; other site 1302863004621 Walker B; other site 1302863004622 D-loop; other site 1302863004623 H-loop/switch region; other site 1302863004624 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 1302863004625 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 1302863004626 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 1302863004627 putative active site [active] 1302863004628 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1302863004629 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1302863004630 Walker A/P-loop; other site 1302863004631 ATP binding site [chemical binding]; other site 1302863004632 Q-loop/lid; other site 1302863004633 ABC transporter signature motif; other site 1302863004634 Walker B; other site 1302863004635 D-loop; other site 1302863004636 H-loop/switch region; other site 1302863004637 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1302863004638 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1302863004639 Walker A/P-loop; other site 1302863004640 ATP binding site [chemical binding]; other site 1302863004641 Q-loop/lid; other site 1302863004642 ABC transporter signature motif; other site 1302863004643 Walker B; other site 1302863004644 D-loop; other site 1302863004645 H-loop/switch region; other site 1302863004646 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1302863004647 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1302863004648 catalytic residues [active] 1302863004649 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1302863004650 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1302863004651 non-specific DNA binding site [nucleotide binding]; other site 1302863004652 salt bridge; other site 1302863004653 sequence-specific DNA binding site [nucleotide binding]; other site 1302863004654 Domain of unknown function (DUF4299); Region: DUF4299; pfam14132 1302863004655 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1302863004656 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1302863004657 active site residue [active] 1302863004658 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 1302863004659 CAAX protease self-immunity; Region: Abi; pfam02517 1302863004660 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1302863004661 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1302863004662 non-specific DNA binding site [nucleotide binding]; other site 1302863004663 salt bridge; other site 1302863004664 sequence-specific DNA binding site [nucleotide binding]; other site 1302863004665 hypothetical protein; Provisional; Region: PRK13661 1302863004666 Uncharacterized conserved protein [Function unknown]; Region: COG1912 1302863004667 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 1302863004668 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 1302863004669 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 1302863004670 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1302863004671 Walker A/P-loop; other site 1302863004672 ATP binding site [chemical binding]; other site 1302863004673 Q-loop/lid; other site 1302863004674 ABC transporter signature motif; other site 1302863004675 Walker B; other site 1302863004676 D-loop; other site 1302863004677 H-loop/switch region; other site 1302863004678 NIL domain; Region: NIL; pfam09383 1302863004679 hypothetical protein; Provisional; Region: PRK06446 1302863004680 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 1302863004681 metal binding site [ion binding]; metal-binding site 1302863004682 dimer interface [polypeptide binding]; other site 1302863004683 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 1302863004684 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1302863004685 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1302863004686 substrate binding pocket [chemical binding]; other site 1302863004687 membrane-bound complex binding site; other site 1302863004688 hinge residues; other site 1302863004689 M20 Peptidase Aminoacyclase-1 YxeP-like proteins, including YxeP, YtnL, YjiB and HipO2; Region: M20_Acy1_YxeP_like; cd05669 1302863004690 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1302863004691 metal binding site [ion binding]; metal-binding site 1302863004692 dimer interface [polypeptide binding]; other site 1302863004693 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 1302863004694 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1302863004695 active site 1302863004696 catalytic residues [active] 1302863004697 metal binding site [ion binding]; metal-binding site 1302863004698 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1302863004699 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1302863004700 nucleotide binding site [chemical binding]; other site 1302863004701 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 1302863004702 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1302863004703 active site turn [active] 1302863004704 phosphorylation site [posttranslational modification] 1302863004705 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1302863004706 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1302863004707 HPr interaction site; other site 1302863004708 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1302863004709 active site 1302863004710 phosphorylation site [posttranslational modification] 1302863004711 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 1302863004712 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1302863004713 substrate binding [chemical binding]; other site 1302863004714 active site 1302863004715 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1302863004716 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1302863004717 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1302863004718 DNA binding site [nucleotide binding] 1302863004719 domain linker motif; other site 1302863004720 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 1302863004721 dimerization interface [polypeptide binding]; other site 1302863004722 ligand binding site [chemical binding]; other site 1302863004723 sodium binding site [ion binding]; other site 1302863004724 Helix-turn-helix domain; Region: HTH_38; pfam13936 1302863004725 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 1302863004726 Integrase core domain; Region: rve; pfam00665 1302863004727 Integrase core domain; Region: rve_3; cl15866 1302863004728 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 1302863004729 pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102 1302863004730 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 1302863004731 carbohydrate binding site [chemical binding]; other site 1302863004732 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 1302863004733 carbohydrate binding site [chemical binding]; other site 1302863004734 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1302863004735 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 1302863004736 Ca binding site [ion binding]; other site 1302863004737 active site 1302863004738 catalytic site [active] 1302863004739 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 1302863004740 putative RNA binding site [nucleotide binding]; other site 1302863004741 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1302863004742 elongation factor P; Validated; Region: PRK00529 1302863004743 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1302863004744 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1302863004745 RNA binding site [nucleotide binding]; other site 1302863004746 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1302863004747 RNA binding site [nucleotide binding]; other site 1302863004748 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1302863004749 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1302863004750 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1302863004751 active site 1302863004752 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1302863004753 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1302863004754 active site 1302863004755 motif I; other site 1302863004756 motif II; other site 1302863004757 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1302863004758 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545 1302863004759 putative nucleotide binding site [chemical binding]; other site 1302863004760 putative metal binding site [ion binding]; other site 1302863004761 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 1302863004762 active site 1302863004763 homotetramer interface [polypeptide binding]; other site 1302863004764 homodimer interface [polypeptide binding]; other site 1302863004765 hypothetical protein; Provisional; Region: PRK02539 1302863004766 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 1302863004767 DALR anticodon binding domain; Region: DALR_1; pfam05746 1302863004768 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1302863004769 dimer interface [polypeptide binding]; other site 1302863004770 motif 1; other site 1302863004771 active site 1302863004772 motif 2; other site 1302863004773 motif 3; other site 1302863004774 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 1302863004775 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1302863004776 active pocket/dimerization site; other site 1302863004777 active site 1302863004778 phosphorylation site [posttranslational modification] 1302863004779 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1302863004780 active site 1302863004781 phosphorylation site [posttranslational modification] 1302863004782 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1302863004783 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 1302863004784 Domain of unknown function (DUF956); Region: DUF956; cl01917 1302863004785 seryl-tRNA synthetase; Provisional; Region: PRK05431 1302863004786 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1302863004787 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1302863004788 dimer interface [polypeptide binding]; other site 1302863004789 active site 1302863004790 motif 1; other site 1302863004791 motif 2; other site 1302863004792 motif 3; other site 1302863004793 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1302863004794 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1302863004795 peptide binding site [polypeptide binding]; other site 1302863004796 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 1302863004797 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1302863004798 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1302863004799 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 1302863004800 FeS assembly protein SufB; Region: sufB; TIGR01980 1302863004801 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1302863004802 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1302863004803 trimerization site [polypeptide binding]; other site 1302863004804 active site 1302863004805 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1302863004806 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1302863004807 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1302863004808 catalytic residue [active] 1302863004809 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 1302863004810 FeS assembly protein SufD; Region: sufD; TIGR01981 1302863004811 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 1302863004812 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1302863004813 Walker A/P-loop; other site 1302863004814 ATP binding site [chemical binding]; other site 1302863004815 Q-loop/lid; other site 1302863004816 ABC transporter signature motif; other site 1302863004817 Walker B; other site 1302863004818 D-loop; other site 1302863004819 H-loop/switch region; other site 1302863004820 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1302863004821 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1302863004822 Mg++ binding site [ion binding]; other site 1302863004823 putative catalytic motif [active] 1302863004824 adaptor protein; Provisional; Region: PRK02315 1302863004825 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1302863004826 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 1302863004827 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1302863004828 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1302863004829 substrate binding pocket [chemical binding]; other site 1302863004830 membrane-bound complex binding site; other site 1302863004831 hinge residues; other site 1302863004832 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302863004833 dimer interface [polypeptide binding]; other site 1302863004834 conserved gate region; other site 1302863004835 putative PBP binding loops; other site 1302863004836 ABC-ATPase subunit interface; other site 1302863004837 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1302863004838 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1302863004839 Walker A/P-loop; other site 1302863004840 ATP binding site [chemical binding]; other site 1302863004841 Q-loop/lid; other site 1302863004842 ABC transporter signature motif; other site 1302863004843 Walker B; other site 1302863004844 D-loop; other site 1302863004845 H-loop/switch region; other site 1302863004846 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1302863004847 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 1302863004848 threonine dehydratase; Validated; Region: PRK08639 1302863004849 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1302863004850 tetramer interface [polypeptide binding]; other site 1302863004851 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302863004852 catalytic residue [active] 1302863004853 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 1302863004854 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1302863004855 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1302863004856 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1302863004857 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1302863004858 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1302863004859 putative valine binding site [chemical binding]; other site 1302863004860 dimer interface [polypeptide binding]; other site 1302863004861 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1302863004862 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07282 1302863004863 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1302863004864 PYR/PP interface [polypeptide binding]; other site 1302863004865 dimer interface [polypeptide binding]; other site 1302863004866 TPP binding site [chemical binding]; other site 1302863004867 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1302863004868 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1302863004869 TPP-binding site [chemical binding]; other site 1302863004870 dimer interface [polypeptide binding]; other site 1302863004871 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1302863004872 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302863004873 active site 1302863004874 phosphorylation site [posttranslational modification] 1302863004875 intermolecular recognition site; other site 1302863004876 dimerization interface [polypeptide binding]; other site 1302863004877 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1302863004878 DNA binding residues [nucleotide binding] 1302863004879 dimerization interface [polypeptide binding]; other site 1302863004880 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1302863004881 Histidine kinase; Region: HisKA_3; pfam07730 1302863004882 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302863004883 ATP binding site [chemical binding]; other site 1302863004884 Mg2+ binding site [ion binding]; other site 1302863004885 G-X-G motif; other site 1302863004886 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1302863004887 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1302863004888 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1302863004889 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1302863004890 Walker A/P-loop; other site 1302863004891 ATP binding site [chemical binding]; other site 1302863004892 Q-loop/lid; other site 1302863004893 ABC transporter signature motif; other site 1302863004894 Walker B; other site 1302863004895 D-loop; other site 1302863004896 H-loop/switch region; other site 1302863004897 Protein of unknown function (DUF1307); Region: DUF1307; cl01981 1302863004898 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 1302863004899 DAK2 domain; Region: Dak2; pfam02734 1302863004900 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1302863004901 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1302863004902 LytTr DNA-binding domain; Region: LytTR; smart00850 1302863004903 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 1302863004904 Predicted membrane protein [Function unknown]; Region: COG2323 1302863004905 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 1302863004906 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1302863004907 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1302863004908 Domain of unknown function (DUF389); Region: DUF389; pfam04087 1302863004909 Ion channel; Region: Ion_trans_2; pfam07885 1302863004910 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1302863004911 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1302863004912 23S rRNA interface [nucleotide binding]; other site 1302863004913 L3 interface [polypeptide binding]; other site 1302863004914 EDD domain protein, DegV family; Region: DegV; TIGR00762 1302863004915 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 1302863004916 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1302863004917 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1302863004918 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1302863004919 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1302863004920 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1302863004921 non-specific DNA binding site [nucleotide binding]; other site 1302863004922 salt bridge; other site 1302863004923 sequence-specific DNA binding site [nucleotide binding]; other site 1302863004924 trigger factor; Provisional; Region: tig; PRK01490 1302863004925 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1302863004926 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1302863004927 hypothetical protein; Provisional; Region: PRK13690 1302863004928 ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155 1302863004929 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 1302863004930 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1302863004931 substrate binding site [chemical binding]; other site 1302863004932 dimer interface [polypeptide binding]; other site 1302863004933 ATP binding site [chemical binding]; other site 1302863004934 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1302863004935 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1302863004936 dimerization interface 3.5A [polypeptide binding]; other site 1302863004937 active site 1302863004938 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1302863004939 nudix motif; other site 1302863004940 FtsX-like permease family; Region: FtsX; pfam02687 1302863004941 FtsX-like permease family; Region: FtsX; pfam02687 1302863004942 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1302863004943 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1302863004944 Walker A/P-loop; other site 1302863004945 ATP binding site [chemical binding]; other site 1302863004946 Q-loop/lid; other site 1302863004947 ABC transporter signature motif; other site 1302863004948 Walker B; other site 1302863004949 D-loop; other site 1302863004950 H-loop/switch region; other site 1302863004951 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1302863004952 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1302863004953 WHG domain; Region: WHG; pfam13305 1302863004954 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 1302863004955 HlyD family secretion protein; Region: HlyD_3; pfam13437 1302863004956 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 1302863004957 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 1302863004958 putative active site [active] 1302863004959 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1302863004960 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1302863004961 Walker A/P-loop; other site 1302863004962 ATP binding site [chemical binding]; other site 1302863004963 Q-loop/lid; other site 1302863004964 ABC transporter signature motif; other site 1302863004965 Walker B; other site 1302863004966 D-loop; other site 1302863004967 H-loop/switch region; other site 1302863004968 ribonuclease HIII; Provisional; Region: PRK00996 1302863004969 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 1302863004970 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 1302863004971 RNA/DNA hybrid binding site [nucleotide binding]; other site 1302863004972 active site 1302863004973 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1302863004974 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 1302863004975 Catalytic site [active] 1302863004976 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 1302863004977 Ras GTPase Activating Domain; Region: RasGAP; cl02569 1302863004978 AAA domain; Region: AAA_30; pfam13604 1302863004979 Family description; Region: UvrD_C_2; pfam13538 1302863004980 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1302863004981 active site 1302863004982 DNA polymerase IV; Validated; Region: PRK02406 1302863004983 DNA binding site [nucleotide binding] 1302863004984 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1302863004985 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1302863004986 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1302863004987 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1302863004988 Uncharacterized conserved protein [Function unknown]; Region: COG3610 1302863004989 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 1302863004990 homodimer interface [polypeptide binding]; other site 1302863004991 catalytic residues [active] 1302863004992 NAD binding site [chemical binding]; other site 1302863004993 substrate binding pocket [chemical binding]; other site 1302863004994 flexible flap; other site 1302863004995 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 1302863004996 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 1302863004997 dimer interface [polypeptide binding]; other site 1302863004998 active site 1302863004999 GTP-binding protein Der; Reviewed; Region: PRK00093 1302863005000 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1302863005001 G1 box; other site 1302863005002 GTP/Mg2+ binding site [chemical binding]; other site 1302863005003 Switch I region; other site 1302863005004 G2 box; other site 1302863005005 Switch II region; other site 1302863005006 G3 box; other site 1302863005007 G4 box; other site 1302863005008 G5 box; other site 1302863005009 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1302863005010 G1 box; other site 1302863005011 GTP/Mg2+ binding site [chemical binding]; other site 1302863005012 Switch I region; other site 1302863005013 G2 box; other site 1302863005014 G3 box; other site 1302863005015 Switch II region; other site 1302863005016 G4 box; other site 1302863005017 G5 box; other site 1302863005018 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1302863005019 dimer interface [polypeptide binding]; other site 1302863005020 FMN binding site [chemical binding]; other site 1302863005021 NADPH bind site [chemical binding]; other site 1302863005022 primosomal protein DnaI; Reviewed; Region: PRK08939 1302863005023 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 1302863005024 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1302863005025 Walker A motif; other site 1302863005026 ATP binding site [chemical binding]; other site 1302863005027 Walker B motif; other site 1302863005028 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 1302863005029 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1302863005030 ATP cone domain; Region: ATP-cone; pfam03477 1302863005031 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1302863005032 amino acid carrier protein; Region: agcS; TIGR00835 1302863005033 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1302863005034 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1302863005035 acetyl-CoA carboxylase subunit alpha; Provisional; Region: PRK12319 1302863005036 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1302863005037 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 1302863005038 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1302863005039 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1302863005040 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1302863005041 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1302863005042 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1302863005043 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1302863005044 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1302863005045 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1302863005046 carboxyltransferase (CT) interaction site; other site 1302863005047 biotinylation site [posttranslational modification]; other site 1302863005048 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1302863005049 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1302863005050 dimer interface [polypeptide binding]; other site 1302863005051 active site 1302863005052 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1302863005053 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1302863005054 NAD(P) binding site [chemical binding]; other site 1302863005055 homotetramer interface [polypeptide binding]; other site 1302863005056 homodimer interface [polypeptide binding]; other site 1302863005057 active site 1302863005058 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1302863005059 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1302863005060 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 1302863005061 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 1302863005062 FMN binding site [chemical binding]; other site 1302863005063 substrate binding site [chemical binding]; other site 1302863005064 putative catalytic residue [active] 1302863005065 acyl carrier protein; Provisional; Region: acpP; PRK00982 1302863005066 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1302863005067 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1302863005068 dimer interface [polypeptide binding]; other site 1302863005069 active site 1302863005070 CoA binding pocket [chemical binding]; other site 1302863005071 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1302863005072 MarR family; Region: MarR_2; cl17246 1302863005073 enoyl-CoA hydratase; Provisional; Region: PRK07260 1302863005074 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1302863005075 substrate binding site [chemical binding]; other site 1302863005076 oxyanion hole (OAH) forming residues; other site 1302863005077 trimer interface [polypeptide binding]; other site 1302863005078 aspartate kinase; Reviewed; Region: PRK09034 1302863005079 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 1302863005080 putative catalytic residues [active] 1302863005081 putative nucleotide binding site [chemical binding]; other site 1302863005082 putative aspartate binding site [chemical binding]; other site 1302863005083 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 1302863005084 allosteric regulatory residue; other site 1302863005085 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 1302863005086 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1302863005087 EamA-like transporter family; Region: EamA; pfam00892 1302863005088 Protein of unknown function (DUF2846); Region: DUF2846; pfam11008 1302863005089 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1302863005090 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1302863005091 GatB domain; Region: GatB_Yqey; pfam02637 1302863005092 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1302863005093 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1302863005094 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1302863005095 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1302863005096 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1302863005097 dimer interface [polypeptide binding]; other site 1302863005098 anticodon binding site; other site 1302863005099 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1302863005100 homodimer interface [polypeptide binding]; other site 1302863005101 motif 1; other site 1302863005102 active site 1302863005103 motif 2; other site 1302863005104 GAD domain; Region: GAD; pfam02938 1302863005105 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1302863005106 active site 1302863005107 motif 3; other site 1302863005108 Isochorismatase family; Region: Isochorismatase; pfam00857 1302863005109 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1302863005110 catalytic triad [active] 1302863005111 conserved cis-peptide bond; other site 1302863005112 Pleiotropic transcriptional repressor [Transcription]; Region: CodY; COG4465 1302863005113 CodY GAF-like domain; Region: CodY; pfam06018 1302863005114 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1302863005115 dimerization interface [polypeptide binding]; other site 1302863005116 putative Zn2+ binding site [ion binding]; other site 1302863005117 putative DNA binding site [nucleotide binding]; other site 1302863005118 aminotransferase AlaT; Validated; Region: PRK09265 1302863005119 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1302863005120 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1302863005121 homodimer interface [polypeptide binding]; other site 1302863005122 catalytic residue [active] 1302863005123 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1302863005124 Ligand Binding Site [chemical binding]; other site 1302863005125 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1302863005126 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1302863005127 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1302863005128 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1302863005129 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1302863005130 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 1302863005131 Cl binding site [ion binding]; other site 1302863005132 oligomer interface [polypeptide binding]; other site 1302863005133 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 1302863005134 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1302863005135 Coenzyme A binding pocket [chemical binding]; other site 1302863005136 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1302863005137 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1302863005138 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1302863005139 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1302863005140 dimer interface [polypeptide binding]; other site 1302863005141 ssDNA binding site [nucleotide binding]; other site 1302863005142 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1302863005143 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1302863005144 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 1302863005145 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 1302863005146 homotetramer interface [polypeptide binding]; other site 1302863005147 FMN binding site [chemical binding]; other site 1302863005148 homodimer contacts [polypeptide binding]; other site 1302863005149 putative active site [active] 1302863005150 putative substrate binding site [chemical binding]; other site 1302863005151 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 1302863005152 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1302863005153 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1302863005154 diphosphomevalonate decarboxylase; Region: PLN02407 1302863005155 diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240 1302863005156 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 1302863005157 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1302863005158 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1302863005159 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1302863005160 Beta-lactamase; Region: Beta-lactamase; pfam00144 1302863005161 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1302863005162 active site 1302863005163 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1302863005164 amphipathic channel; other site 1302863005165 Asn-Pro-Ala signature motifs; other site 1302863005166 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 1302863005167 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; pfam09168 1302863005168 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 1302863005169 hypothetical protein; Validated; Region: PRK00153 1302863005170 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1302863005171 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1302863005172 purine monophosphate binding site [chemical binding]; other site 1302863005173 dimer interface [polypeptide binding]; other site 1302863005174 putative catalytic residues [active] 1302863005175 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1302863005176 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1302863005177 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 1302863005178 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1302863005179 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1302863005180 active site 1302863005181 substrate binding site [chemical binding]; other site 1302863005182 cosubstrate binding site; other site 1302863005183 catalytic site [active] 1302863005184 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1302863005185 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1302863005186 dimerization interface [polypeptide binding]; other site 1302863005187 putative ATP binding site [chemical binding]; other site 1302863005188 amidophosphoribosyltransferase; Provisional; Region: PRK07272 1302863005189 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1302863005190 active site 1302863005191 tetramer interface [polypeptide binding]; other site 1302863005192 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1302863005193 active site 1302863005194 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 1302863005195 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 1302863005196 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1302863005197 dimerization interface [polypeptide binding]; other site 1302863005198 ATP binding site [chemical binding]; other site 1302863005199 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 1302863005200 dimerization interface [polypeptide binding]; other site 1302863005201 ATP binding site [chemical binding]; other site 1302863005202 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1302863005203 putative active site [active] 1302863005204 catalytic triad [active] 1302863005205 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1302863005206 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1302863005207 ATP binding site [chemical binding]; other site 1302863005208 active site 1302863005209 substrate binding site [chemical binding]; other site 1302863005210 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1302863005211 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1302863005212 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1302863005213 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 1302863005214 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 1302863005215 DNA binding residues [nucleotide binding] 1302863005216 putative dimer interface [polypeptide binding]; other site 1302863005217 Predicted membrane protein [Function unknown]; Region: COG4129 1302863005218 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 1302863005219 Phosphoglycerate kinase; Region: PGK; pfam00162 1302863005220 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1302863005221 substrate binding site [chemical binding]; other site 1302863005222 hinge regions; other site 1302863005223 ADP binding site [chemical binding]; other site 1302863005224 catalytic site [active] 1302863005225 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1302863005226 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1302863005227 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1302863005228 elongation factor G; Reviewed; Region: PRK00007 1302863005229 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1302863005230 G1 box; other site 1302863005231 putative GEF interaction site [polypeptide binding]; other site 1302863005232 GTP/Mg2+ binding site [chemical binding]; other site 1302863005233 Switch I region; other site 1302863005234 G2 box; other site 1302863005235 G3 box; other site 1302863005236 Switch II region; other site 1302863005237 G4 box; other site 1302863005238 G5 box; other site 1302863005239 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1302863005240 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1302863005241 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1302863005242 30S ribosomal protein S7; Validated; Region: PRK05302 1302863005243 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1302863005244 S17 interaction site [polypeptide binding]; other site 1302863005245 S8 interaction site; other site 1302863005246 16S rRNA interaction site [nucleotide binding]; other site 1302863005247 streptomycin interaction site [chemical binding]; other site 1302863005248 23S rRNA interaction site [nucleotide binding]; other site 1302863005249 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1302863005250 pur operon repressor; Provisional; Region: PRK09213 1302863005251 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 1302863005252 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1302863005253 active site 1302863005254 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 1302863005255 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 1302863005256 generic binding surface II; other site 1302863005257 generic binding surface I; other site 1302863005258 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1302863005259 Zn2+ binding site [ion binding]; other site 1302863005260 Mg2+ binding site [ion binding]; other site 1302863005261 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 1302863005262 RmuC family; Region: RmuC; pfam02646 1302863005263 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 1302863005264 Thiamine pyrophosphokinase; Region: TPK; cd07995 1302863005265 active site 1302863005266 dimerization interface [polypeptide binding]; other site 1302863005267 thiamine binding site [chemical binding]; other site 1302863005268 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1302863005269 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1302863005270 substrate binding site [chemical binding]; other site 1302863005271 hexamer interface [polypeptide binding]; other site 1302863005272 metal binding site [ion binding]; metal-binding site 1302863005273 GTPase RsgA; Reviewed; Region: PRK00098 1302863005274 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 1302863005275 RNA binding site [nucleotide binding]; other site 1302863005276 homodimer interface [polypeptide binding]; other site 1302863005277 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1302863005278 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1302863005279 GTP/Mg2+ binding site [chemical binding]; other site 1302863005280 G4 box; other site 1302863005281 G1 box; other site 1302863005282 Switch I region; other site 1302863005283 G2 box; other site 1302863005284 G3 box; other site 1302863005285 Switch II region; other site 1302863005286 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1302863005287 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1302863005288 S-adenosylmethionine binding site [chemical binding]; other site 1302863005289 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 1302863005290 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 1302863005291 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 1302863005292 putative active site [active] 1302863005293 putative metal binding site [ion binding]; other site 1302863005294 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 1302863005295 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1302863005296 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1302863005297 active site 1302863005298 Predicted transcriptional regulator [Transcription]; Region: COG3655 1302863005299 Domain of unknown function (DUF4173); Region: DUF4173; pfam13777 1302863005300 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 1302863005301 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 1302863005302 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 1302863005303 G-X-X-G motif; other site 1302863005304 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 1302863005305 RxxxH motif; other site 1302863005306 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 1302863005307 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1302863005308 ribonuclease P; Reviewed; Region: rnpA; PRK00499 1302863005309 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1302863005310 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1302863005311 active site 1302863005312 HIGH motif; other site 1302863005313 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1302863005314 active site 1302863005315 KMSKS motif; other site 1302863005316 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 1302863005317 Predicted esterase [General function prediction only]; Region: COG0627 1302863005318 S-formylglutathione hydrolase; Region: PLN02442 1302863005319 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 1302863005320 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1302863005321 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 1302863005322 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1302863005323 beta-galactosidase; Region: BGL; TIGR03356 1302863005324 TOBE domain; Region: TOBE; pfam03459 1302863005325 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1302863005326 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 1302863005327 Walker A/P-loop; other site 1302863005328 ATP binding site [chemical binding]; other site 1302863005329 Q-loop/lid; other site 1302863005330 ABC transporter signature motif; other site 1302863005331 Walker B; other site 1302863005332 D-loop; other site 1302863005333 H-loop/switch region; other site 1302863005334 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 1302863005335 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302863005336 active site 1302863005337 phosphorylation site [posttranslational modification] 1302863005338 intermolecular recognition site; other site 1302863005339 dimerization interface [polypeptide binding]; other site 1302863005340 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1302863005341 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1302863005342 Histidine kinase; Region: His_kinase; pfam06580 1302863005343 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302863005344 ATP binding site [chemical binding]; other site 1302863005345 Mg2+ binding site [ion binding]; other site 1302863005346 G-X-G motif; other site 1302863005347 Protein of unknown function, DUF624; Region: DUF624; cl02369 1302863005348 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1302863005349 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 1302863005350 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1302863005351 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302863005352 dimer interface [polypeptide binding]; other site 1302863005353 conserved gate region; other site 1302863005354 putative PBP binding loops; other site 1302863005355 ABC-ATPase subunit interface; other site 1302863005356 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1302863005357 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302863005358 dimer interface [polypeptide binding]; other site 1302863005359 conserved gate region; other site 1302863005360 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1302863005361 ABC-ATPase subunit interface; other site 1302863005362 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 1302863005363 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 1302863005364 putative active site [active] 1302863005365 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1302863005366 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1302863005367 nucleotide binding site [chemical binding]; other site 1302863005368 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 1302863005369 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 1302863005370 active site 1302863005371 metal binding site [ion binding]; metal-binding site 1302863005372 homodimer interface [polypeptide binding]; other site 1302863005373 catalytic site [active] 1302863005374 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 1302863005375 Uncharacterized conserved protein [Function unknown]; Region: COG3538 1302863005376 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 1302863005377 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 1302863005378 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 1302863005379 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 1302863005380 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 1302863005381 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 1302863005382 Calx-beta domain; Region: Calx-beta; cl02522 1302863005383 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 1302863005384 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1302863005385 catalytic Zn binding site [ion binding]; other site 1302863005386 NAD(P) binding site [chemical binding]; other site 1302863005387 structural Zn binding site [ion binding]; other site 1302863005388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 1302863005389 Small integral membrane protein [Function unknown]; Region: COG5547 1302863005390 Predicted membrane protein [Function unknown]; Region: COG2261 1302863005391 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 1302863005392 Mga helix-turn-helix domain; Region: Mga; pfam05043 1302863005393 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 1302863005394 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 1302863005395 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1302863005396 Walker A/P-loop; other site 1302863005397 ATP binding site [chemical binding]; other site 1302863005398 Q-loop/lid; other site 1302863005399 ABC transporter signature motif; other site 1302863005400 Walker B; other site 1302863005401 D-loop; other site 1302863005402 H-loop/switch region; other site 1302863005403 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1302863005404 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 1302863005405 TM-ABC transporter signature motif; other site 1302863005406 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 1302863005407 active site clefts [active] 1302863005408 zinc binding site [ion binding]; other site 1302863005409 dimer interface [polypeptide binding]; other site 1302863005410 Uncharacterized conserved protein [Function unknown]; Region: COG2013 1302863005411 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1302863005412 Walker A motif; other site 1302863005413 ATP binding site [chemical binding]; other site 1302863005414 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1302863005415 Walker B motif; other site 1302863005416 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1302863005417 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1302863005418 catalytic core [active] 1302863005419 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1302863005420 trimer interface [polypeptide binding]; other site 1302863005421 active site 1302863005422 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 1302863005423 putative active site [active] 1302863005424 nucleotide binding site [chemical binding]; other site 1302863005425 nudix motif; other site 1302863005426 putative metal binding site [ion binding]; other site 1302863005427 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 1302863005428 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1302863005429 catalytic triad [active] 1302863005430 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 1302863005431 RNA methyltransferase, RsmE family; Region: TIGR00046 1302863005432 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1302863005433 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1302863005434 S-adenosylmethionine binding site [chemical binding]; other site 1302863005435 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1302863005436 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1302863005437 Coenzyme A binding pocket [chemical binding]; other site 1302863005438 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 1302863005439 nudix motif; other site 1302863005440 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 1302863005441 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 1302863005442 recombination factor protein RarA; Reviewed; Region: PRK13342 1302863005443 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1302863005444 Walker A motif; other site 1302863005445 ATP binding site [chemical binding]; other site 1302863005446 Walker B motif; other site 1302863005447 arginine finger; other site 1302863005448 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1302863005449 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1302863005450 Int/Topo IB signature motif; other site 1302863005451 Domain of unknown function (DUF3173); Region: DUF3173; pfam11372 1302863005452 Replication initiation factor; Region: Rep_trans; pfam02486 1302863005453 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1302863005454 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1302863005455 non-specific DNA binding site [nucleotide binding]; other site 1302863005456 salt bridge; other site 1302863005457 sequence-specific DNA binding site [nucleotide binding]; other site 1302863005458 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 1302863005459 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1302863005460 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1302863005461 Coenzyme A binding pocket [chemical binding]; other site 1302863005462 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1302863005463 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1302863005464 ring oligomerisation interface [polypeptide binding]; other site 1302863005465 ATP/Mg binding site [chemical binding]; other site 1302863005466 stacking interactions; other site 1302863005467 hinge regions; other site 1302863005468 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1302863005469 oligomerisation interface [polypeptide binding]; other site 1302863005470 mobile loop; other site 1302863005471 roof hairpin; other site 1302863005472 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1302863005473 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1302863005474 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1302863005475 Walker A/P-loop; other site 1302863005476 ATP binding site [chemical binding]; other site 1302863005477 Q-loop/lid; other site 1302863005478 ABC transporter signature motif; other site 1302863005479 Walker B; other site 1302863005480 D-loop; other site 1302863005481 H-loop/switch region; other site 1302863005482 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1302863005483 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1302863005484 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1302863005485 Walker A/P-loop; other site 1302863005486 ATP binding site [chemical binding]; other site 1302863005487 Q-loop/lid; other site 1302863005488 ABC transporter signature motif; other site 1302863005489 Walker B; other site 1302863005490 D-loop; other site 1302863005491 H-loop/switch region; other site 1302863005492 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1302863005493 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1302863005494 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1302863005495 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1302863005496 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1302863005497 active site 1302863005498 tetramer interface; other site 1302863005499 Rhomboid family; Region: Rhomboid; pfam01694 1302863005500 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1302863005501 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 1302863005502 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 1302863005503 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 1302863005504 metal binding site [ion binding]; metal-binding site 1302863005505 putative dimer interface [polypeptide binding]; other site 1302863005506 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 1302863005507 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 1302863005508 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1302863005509 trimer interface [polypeptide binding]; other site 1302863005510 active site 1302863005511 substrate binding site [chemical binding]; other site 1302863005512 CoA binding site [chemical binding]; other site 1302863005513 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 1302863005514 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1302863005515 active site 1302863005516 dimer interface [polypeptide binding]; other site 1302863005517 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1302863005518 dimer interface [polypeptide binding]; other site 1302863005519 active site 1302863005520 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1302863005521 nucleoside/Zn binding site; other site 1302863005522 dimer interface [polypeptide binding]; other site 1302863005523 catalytic motif [active] 1302863005524 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1302863005525 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1302863005526 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1302863005527 Walker A/P-loop; other site 1302863005528 ATP binding site [chemical binding]; other site 1302863005529 Q-loop/lid; other site 1302863005530 ABC transporter signature motif; other site 1302863005531 Walker B; other site 1302863005532 D-loop; other site 1302863005533 H-loop/switch region; other site 1302863005534 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1302863005535 Acid Phosphatase; Region: Acid_PPase; cl17256 1302863005536 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1302863005537 motif II; other site 1302863005538 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1302863005539 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1302863005540 GDP-binding site [chemical binding]; other site 1302863005541 ACT binding site; other site 1302863005542 IMP binding site; other site 1302863005543 bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471 1302863005544 Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352 1302863005545 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1302863005546 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1302863005547 Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853 1302863005548 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1302863005549 dimer interface [polypeptide binding]; other site 1302863005550 catalytic triad [active] 1302863005551 peroxidatic and resolving cysteines [active] 1302863005552 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1302863005553 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1302863005554 metal binding site [ion binding]; metal-binding site 1302863005555 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1302863005556 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1302863005557 ABC-ATPase subunit interface; other site 1302863005558 dimer interface [polypeptide binding]; other site 1302863005559 putative PBP binding regions; other site 1302863005560 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1302863005561 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1302863005562 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 1302863005563 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 1302863005564 active site 1302863005565 Zn binding site [ion binding]; other site 1302863005566 Ion channel; Region: Ion_trans_2; pfam07885 1302863005567 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1302863005568 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1302863005569 HIGH motif; other site 1302863005570 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1302863005571 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1302863005572 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1302863005573 active site 1302863005574 KMSKS motif; other site 1302863005575 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1302863005576 tRNA binding surface [nucleotide binding]; other site 1302863005577 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 1302863005578 elongation factor Ts; Provisional; Region: tsf; PRK09377 1302863005579 UBA/TS-N domain; Region: UBA; pfam00627 1302863005580 Elongation factor TS; Region: EF_TS; pfam00889 1302863005581 Elongation factor TS; Region: EF_TS; pfam00889 1302863005582 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1302863005583 rRNA interaction site [nucleotide binding]; other site 1302863005584 S8 interaction site; other site 1302863005585 putative laminin-1 binding site; other site 1302863005586 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1302863005587 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1302863005588 putative homodimer interface [polypeptide binding]; other site 1302863005589 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1302863005590 heterodimer interface [polypeptide binding]; other site 1302863005591 homodimer interface [polypeptide binding]; other site 1302863005592 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 1302863005593 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 1302863005594 Transglycosylase; Region: Transgly; pfam00912 1302863005595 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 1302863005596 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1302863005597 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1302863005598 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1302863005599 active site 1302863005600 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1302863005601 nucleotide binding site [chemical binding]; other site 1302863005602 butyrate kinase; Provisional; Region: PRK03011 1302863005603 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1302863005604 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1302863005605 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 1302863005606 Type II secretory pathway pseudopilin; Region: PulG; pfam11773 1302863005607 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1302863005608 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 1302863005609 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1302863005610 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1302863005611 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1302863005612 Type II/IV secretion system protein; Region: T2SE; pfam00437 1302863005613 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1302863005614 Walker A motif; other site 1302863005615 ATP binding site [chemical binding]; other site 1302863005616 Walker B motif; other site 1302863005617 Protein of unknown function (DUF1033); Region: DUF1033; pfam06279 1302863005618 Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843 1302863005619 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1302863005620 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1302863005621 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1302863005622 NAD(P) binding site [chemical binding]; other site 1302863005623 active site 1302863005624 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1302863005625 substrate binding site; other site 1302863005626 dimer interface; other site 1302863005627 LicD family; Region: LicD; cl01378 1302863005628 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1302863005629 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1302863005630 active site 1302863005631 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1302863005632 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1302863005633 active site 1302863005634 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1302863005635 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1302863005636 NAD(P) binding site [chemical binding]; other site 1302863005637 active site 1302863005638 potential frameshift: common BLAST hit: gi|125719002|ref|YP_001036135.1| galactosyltransferase 1302863005639 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 1302863005640 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1302863005641 NAD(P) binding site [chemical binding]; other site 1302863005642 homodimer interface [polypeptide binding]; other site 1302863005643 substrate binding site [chemical binding]; other site 1302863005644 active site 1302863005645 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1302863005646 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1302863005647 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1302863005648 polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006 1302863005649 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 1302863005650 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 1302863005651 DNA polymerase processivity factor; Region: DNA_PPF; pfam02916 1302863005652 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 1302863005653 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 1302863005654 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1302863005655 FeS/SAM binding site; other site 1302863005656 Predicted acetyltransferase [General function prediction only]; Region: COG3981 1302863005657 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1302863005658 Coenzyme A binding pocket [chemical binding]; other site 1302863005659 Predicted acetyltransferase [General function prediction only]; Region: COG3981 1302863005660 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1302863005661 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 1302863005662 ATP cone domain; Region: ATP-cone; pfam03477 1302863005663 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1302863005664 effector binding site; other site 1302863005665 active site 1302863005666 Zn binding site [ion binding]; other site 1302863005667 glycine loop; other site 1302863005668 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1302863005669 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1302863005670 Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154 1302863005671 putative active site [active] 1302863005672 catalytic site [active] 1302863005673 Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160 1302863005674 putative active site [active] 1302863005675 catalytic site [active] 1302863005676 Bacterial lipoprotein; Region: DUF3642; pfam12182 1302863005677 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 1302863005678 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1302863005679 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1302863005680 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1302863005681 hypothetical protein; Provisional; Region: PRK05473 1302863005682 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 1302863005683 ArsC family; Region: ArsC; pfam03960 1302863005684 putative catalytic residues [active] 1302863005685 thiol/disulfide switch; other site 1302863005686 recombinase A; Provisional; Region: recA; PRK09354 1302863005687 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1302863005688 hexamer interface [polypeptide binding]; other site 1302863005689 Walker A motif; other site 1302863005690 ATP binding site [chemical binding]; other site 1302863005691 Walker B motif; other site 1302863005692 competence damage-inducible protein A; Provisional; Region: PRK00549 1302863005693 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1302863005694 putative MPT binding site; other site 1302863005695 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 1302863005696 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1302863005697 non-specific DNA binding site [nucleotide binding]; other site 1302863005698 salt bridge; other site 1302863005699 sequence-specific DNA binding site [nucleotide binding]; other site 1302863005700 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1302863005701 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1302863005702 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 1302863005703 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1302863005704 RuvA N terminal domain; Region: RuvA_N; pfam01330 1302863005705 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1302863005706 non-specific DNA binding site [nucleotide binding]; other site 1302863005707 salt bridge; other site 1302863005708 sequence-specific DNA binding site [nucleotide binding]; other site 1302863005709 RDD family; Region: RDD; pfam06271 1302863005710 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1302863005711 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1302863005712 ATP binding site [chemical binding]; other site 1302863005713 Mg2+ binding site [ion binding]; other site 1302863005714 G-X-G motif; other site 1302863005715 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1302863005716 ATP binding site [chemical binding]; other site 1302863005717 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1302863005718 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1302863005719 LytTr DNA-binding domain; Region: LytTR; smart00850 1302863005720 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 1302863005721 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1302863005722 MutS domain I; Region: MutS_I; pfam01624 1302863005723 MutS domain II; Region: MutS_II; pfam05188 1302863005724 MutS domain III; Region: MutS_III; pfam05192 1302863005725 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1302863005726 Walker A/P-loop; other site 1302863005727 ATP binding site [chemical binding]; other site 1302863005728 Q-loop/lid; other site 1302863005729 ABC transporter signature motif; other site 1302863005730 Walker B; other site 1302863005731 D-loop; other site 1302863005732 H-loop/switch region; other site 1302863005733 Arginine repressor [Transcription]; Region: ArgR; COG1438 1302863005734 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1302863005735 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1302863005736 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 1302863005737 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1302863005738 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1302863005739 active site 1302863005740 HIGH motif; other site 1302863005741 KMSK motif region; other site 1302863005742 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1302863005743 tRNA binding surface [nucleotide binding]; other site 1302863005744 anticodon binding site; other site 1302863005745 flavoprotein NrdI; Provisional; Region: PRK02551 1302863005746 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 1302863005747 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1302863005748 4-alpha-glucanotransferase; Provisional; Region: PRK14508 1302863005749 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 1302863005750 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1302863005751 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302863005752 dimer interface [polypeptide binding]; other site 1302863005753 conserved gate region; other site 1302863005754 putative PBP binding loops; other site 1302863005755 ABC-ATPase subunit interface; other site 1302863005756 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1302863005757 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302863005758 dimer interface [polypeptide binding]; other site 1302863005759 conserved gate region; other site 1302863005760 putative PBP binding loops; other site 1302863005761 ABC-ATPase subunit interface; other site 1302863005762 Predicted integral membrane protein [Function unknown]; Region: COG5521 1302863005763 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1302863005764 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1302863005765 DNA binding site [nucleotide binding] 1302863005766 domain linker motif; other site 1302863005767 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 1302863005768 putative dimerization interface [polypeptide binding]; other site 1302863005769 putative ligand binding site [chemical binding]; other site 1302863005770 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 1302863005771 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 1302863005772 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1302863005773 Ca binding site [ion binding]; other site 1302863005774 active site 1302863005775 catalytic site [active] 1302863005776 Uncharacterized conserved protein [Function unknown]; Region: COG1284 1302863005777 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1302863005778 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 1302863005779 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 1302863005780 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1302863005781 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1302863005782 dimer interface [polypeptide binding]; other site 1302863005783 anticodon binding site; other site 1302863005784 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1302863005785 homodimer interface [polypeptide binding]; other site 1302863005786 motif 1; other site 1302863005787 active site 1302863005788 motif 2; other site 1302863005789 GAD domain; Region: GAD; pfam02938 1302863005790 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1302863005791 active site 1302863005792 motif 3; other site 1302863005793 Protein of unknown function (DUF2185); Region: DUF2185; cl02019 1302863005794 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1302863005795 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1302863005796 Integrase core domain; Region: rve; pfam00665 1302863005797 HTH-like domain; Region: HTH_21; pfam13276 1302863005798 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1302863005799 Homeodomain-like domain; Region: HTH_23; cl17451 1302863005800 Transposase; Region: HTH_Tnp_1; cl17663 1302863005801 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 1302863005802 Domain of unknown function (DUF4299); Region: DUF4299; pfam14132 1302863005803 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 1302863005804 Domain of unknown function (DUF1910); Region: DUF1910; pfam08928 1302863005805 Domain of unknown function (DUF1911); Region: DUF1911; pfam08929 1302863005806 Protein of unknown function (DUF2185); Region: DUF2185; cl02019 1302863005807 Domain of unknown function (DUF1910); Region: DUF1910; pfam08928 1302863005808 Domain of unknown function (DUF1911); Region: DUF1911; pfam08929 1302863005809 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1302863005810 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1302863005811 dimer interface [polypeptide binding]; other site 1302863005812 motif 1; other site 1302863005813 active site 1302863005814 motif 2; other site 1302863005815 motif 3; other site 1302863005816 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1302863005817 anticodon binding site; other site 1302863005818 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1302863005819 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1302863005820 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1302863005821 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1302863005822 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1302863005823 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1302863005824 active site 1302863005825 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1302863005826 Walker A/P-loop; other site 1302863005827 ATP binding site [chemical binding]; other site 1302863005828 AAA domain; Region: AAA_21; pfam13304 1302863005829 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1302863005830 non-specific DNA binding site [nucleotide binding]; other site 1302863005831 salt bridge; other site 1302863005832 sequence-specific DNA binding site [nucleotide binding]; other site 1302863005833 AAA domain; Region: AAA_17; pfam13207 1302863005834 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1302863005835 Maf-like protein; Region: Maf; pfam02545 1302863005836 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1302863005837 active site 1302863005838 dimer interface [polypeptide binding]; other site 1302863005839 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1302863005840 non-specific DNA binding site [nucleotide binding]; other site 1302863005841 salt bridge; other site 1302863005842 sequence-specific DNA binding site [nucleotide binding]; other site 1302863005843 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 1302863005844 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1302863005845 probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366 1302863005846 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1302863005847 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 1302863005848 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1302863005849 putative substrate translocation pore; other site 1302863005850 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1302863005851 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 1302863005852 DltD N-terminal region; Region: DltD_N; pfam04915 1302863005853 DltD central region; Region: DltD_M; pfam04918 1302863005854 DltD C-terminal region; Region: DltD_C; pfam04914 1302863005855 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 1302863005856 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 1302863005857 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 1302863005858 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 1302863005859 acyl-activating enzyme (AAE) consensus motif; other site 1302863005860 AMP binding site [chemical binding]; other site 1302863005861 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 1302863005862 Predicted transcriptional regulators [Transcription]; Region: COG1695 1302863005863 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1302863005864 Predicted membrane protein [Function unknown]; Region: COG4709 1302863005865 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 1302863005866 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 1302863005867 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1302863005868 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1302863005869 motif II; other site 1302863005870 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 1302863005871 putative dimer interface [polypeptide binding]; other site 1302863005872 catalytic triad [active] 1302863005873 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 1302863005874 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 1302863005875 putative metal binding residues [ion binding]; other site 1302863005876 signature motif; other site 1302863005877 dimer interface [polypeptide binding]; other site 1302863005878 active site 1302863005879 polyP binding site; other site 1302863005880 substrate binding site [chemical binding]; other site 1302863005881 acceptor-phosphate pocket; other site 1302863005882 Predicted membrane protein [Function unknown]; Region: COG1511 1302863005883 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 1302863005884 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 1302863005885 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1302863005886 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1302863005887 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 1302863005888 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 1302863005889 Protein of unknown function (DUF1492); Region: DUF1492; pfam07374 1302863005890 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1302863005891 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1302863005892 non-specific DNA binding site [nucleotide binding]; other site 1302863005893 salt bridge; other site 1302863005894 sequence-specific DNA binding site [nucleotide binding]; other site 1302863005895 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1302863005896 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1302863005897 non-specific DNA binding site [nucleotide binding]; other site 1302863005898 salt bridge; other site 1302863005899 sequence-specific DNA binding site [nucleotide binding]; other site 1302863005900 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1302863005901 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 1302863005902 Int/Topo IB signature motif; other site 1302863005903 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1302863005904 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1302863005905 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1302863005906 RNA binding surface [nucleotide binding]; other site 1302863005907 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1302863005908 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1302863005909 Walker A/P-loop; other site 1302863005910 ATP binding site [chemical binding]; other site 1302863005911 Q-loop/lid; other site 1302863005912 ABC transporter signature motif; other site 1302863005913 Walker B; other site 1302863005914 D-loop; other site 1302863005915 H-loop/switch region; other site 1302863005916 NMT1/THI5 like; Region: NMT1; pfam09084 1302863005917 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 1302863005918 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1302863005919 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1302863005920 dimer interface [polypeptide binding]; other site 1302863005921 conserved gate region; other site 1302863005922 putative PBP binding loops; other site 1302863005923 ABC-ATPase subunit interface; other site 1302863005924 Uncharacterized conserved protein [Function unknown]; Region: COG0011 1302863005925 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 1302863005926 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1302863005927 active site 1302863005928 motif I; other site 1302863005929 motif II; other site 1302863005930 Uncharacterized protein conserved in bacteria [Function unknown]; Region: Veg; COG4466 1302863005931 replicative DNA helicase; Provisional; Region: PRK05748 1302863005932 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1302863005933 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1302863005934 Walker A motif; other site 1302863005935 ATP binding site [chemical binding]; other site 1302863005936 Walker B motif; other site 1302863005937 DNA binding loops [nucleotide binding] 1302863005938 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1302863005939 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1302863005940 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1302863005941 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 1302863005942 DHH family; Region: DHH; pfam01368 1302863005943 DHHA1 domain; Region: DHHA1; pfam02272 1302863005944 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1302863005945 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1302863005946 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1302863005947 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 1302863005948 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1302863005949 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1302863005950 Predicted membrane protein [Function unknown]; Region: COG4485 1302863005951 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1302863005952 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1302863005953 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1302863005954 ABC transporter; Region: ABC_tran_2; pfam12848 1302863005955 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1302863005956 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1302863005957 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1302863005958 active site 1302863005959 HIGH motif; other site 1302863005960 dimer interface [polypeptide binding]; other site 1302863005961 KMSKS motif; other site 1302863005962 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1302863005963 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1302863005964 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1302863005965 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1302863005966 active site 1302863005967 recombination protein F; Reviewed; Region: recF; PRK00064 1302863005968 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 1302863005969 Walker A/P-loop; other site 1302863005970 ATP binding site [chemical binding]; other site 1302863005971 Q-loop/lid; other site 1302863005972 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1302863005973 ABC transporter signature motif; other site 1302863005974 Walker B; other site 1302863005975 D-loop; other site 1302863005976 H-loop/switch region; other site 1302863005977 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 1302863005978 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1302863005979 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1302863005980 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1302863005981 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1302863005982 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1302863005983 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 1302863005984 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1302863005985 non-specific DNA binding site [nucleotide binding]; other site 1302863005986 salt bridge; other site 1302863005987 sequence-specific DNA binding site [nucleotide binding]; other site 1302863005988 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1302863005989 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13650 1302863005990 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1302863005991 Walker A/P-loop; other site 1302863005992 ATP binding site [chemical binding]; other site 1302863005993 Q-loop/lid; other site 1302863005994 ABC transporter signature motif; other site 1302863005995 Walker B; other site 1302863005996 D-loop; other site 1302863005997 H-loop/switch region; other site 1302863005998 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13649 1302863005999 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1302863006000 Walker A/P-loop; other site 1302863006001 ATP binding site [chemical binding]; other site 1302863006002 Q-loop/lid; other site 1302863006003 ABC transporter signature motif; other site 1302863006004 Walker B; other site 1302863006005 D-loop; other site 1302863006006 H-loop/switch region; other site 1302863006007 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1302863006008 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1302863006009 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 1302863006010 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 1302863006011 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 1302863006012 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 1302863006013 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1302863006014 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 1302863006015 putative L-serine binding site [chemical binding]; other site 1302863006016 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1302863006017 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1302863006018 active site 1302863006019 phosphorylation site [posttranslational modification] 1302863006020 intermolecular recognition site; other site 1302863006021 dimerization interface [polypeptide binding]; other site 1302863006022 LytTr DNA-binding domain; Region: LytTR; pfam04397 1302863006023 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 1302863006024 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 1302863006025 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1302863006026 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1302863006027 protein binding site [polypeptide binding]; other site 1302863006028 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1302863006029 ParB-like nuclease domain; Region: ParB; smart00470 1302863006030 KorB domain; Region: KorB; pfam08535