-- dump date 20140620_083621 -- class Genbank::misc_feature -- table misc_feature_note -- id note 927666000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 927666000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 927666000003 Walker A motif; other site 927666000004 ATP binding site [chemical binding]; other site 927666000005 Walker B motif; other site 927666000006 arginine finger; other site 927666000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 927666000008 DnaA box-binding interface [nucleotide binding]; other site 927666000009 DNA polymerase III subunit beta; Validated; Region: PRK05643 927666000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 927666000011 putative DNA binding surface [nucleotide binding]; other site 927666000012 dimer interface [polypeptide binding]; other site 927666000013 beta-clamp/clamp loader binding surface; other site 927666000014 beta-clamp/translesion DNA polymerase binding surface; other site 927666000015 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 927666000016 GTP-binding protein YchF; Reviewed; Region: PRK09601 927666000017 YchF GTPase; Region: YchF; cd01900 927666000018 G1 box; other site 927666000019 GTP/Mg2+ binding site [chemical binding]; other site 927666000020 Switch I region; other site 927666000021 G2 box; other site 927666000022 Switch II region; other site 927666000023 G3 box; other site 927666000024 G4 box; other site 927666000025 G5 box; other site 927666000026 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 927666000027 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 927666000028 putative active site [active] 927666000029 catalytic residue [active] 927666000030 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 927666000031 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 927666000032 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 927666000033 ATP binding site [chemical binding]; other site 927666000034 putative Mg++ binding site [ion binding]; other site 927666000035 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 927666000036 nucleotide binding region [chemical binding]; other site 927666000037 ATP-binding site [chemical binding]; other site 927666000038 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 927666000039 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 927666000040 RNA binding surface [nucleotide binding]; other site 927666000041 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 927666000042 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 927666000043 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 927666000044 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 927666000045 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 927666000046 Ligand Binding Site [chemical binding]; other site 927666000047 TilS substrate C-terminal domain; Region: TilS_C; smart00977 927666000048 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 927666000049 active site 927666000050 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 927666000051 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 927666000052 Walker A motif; other site 927666000053 ATP binding site [chemical binding]; other site 927666000054 Walker B motif; other site 927666000055 arginine finger; other site 927666000056 Peptidase family M41; Region: Peptidase_M41; pfam01434 927666000057 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 927666000058 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 927666000059 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 927666000060 GDP-binding site [chemical binding]; other site 927666000061 ACT binding site; other site 927666000062 IMP binding site; other site 927666000063 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 927666000064 nucleoside/Zn binding site; other site 927666000065 dimer interface [polypeptide binding]; other site 927666000066 catalytic motif [active] 927666000067 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 927666000068 trimer interface [polypeptide binding]; other site 927666000069 active site 927666000070 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 927666000071 catalytic core [active] 927666000072 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 927666000073 DNA repair protein RadA; Provisional; Region: PRK11823 927666000074 Walker A motif; other site 927666000075 ATP binding site [chemical binding]; other site 927666000076 Walker B motif; other site 927666000077 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 927666000078 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 927666000079 active site clefts [active] 927666000080 zinc binding site [ion binding]; other site 927666000081 dimer interface [polypeptide binding]; other site 927666000082 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269 927666000083 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 927666000084 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 927666000085 active site 927666000086 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 927666000087 Predicted membrane protein [Function unknown]; Region: COG2855 927666000088 aromatic amino acid aminotransferase; Validated; Region: PRK07309 927666000089 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 927666000090 pyridoxal 5'-phosphate binding site [chemical binding]; other site 927666000091 homodimer interface [polypeptide binding]; other site 927666000092 catalytic residue [active] 927666000093 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 927666000094 Recombination protein O N terminal; Region: RecO_N; pfam11967 927666000095 Recombination protein O C terminal; Region: RecO_C; pfam02565 927666000096 putative phosphate acyltransferase; Provisional; Region: PRK05331 927666000097 Phosphopantetheine attachment site; Region: PP-binding; cl09936 927666000098 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 927666000099 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 927666000100 putative active site [active] 927666000101 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 927666000102 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 927666000103 Walker A/P-loop; other site 927666000104 ATP binding site [chemical binding]; other site 927666000105 Q-loop/lid; other site 927666000106 ABC transporter signature motif; other site 927666000107 Walker B; other site 927666000108 D-loop; other site 927666000109 H-loop/switch region; other site 927666000110 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 927666000111 HlyD family secretion protein; Region: HlyD_3; pfam13437 927666000112 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 927666000113 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 927666000114 ATP binding site [chemical binding]; other site 927666000115 active site 927666000116 substrate binding site [chemical binding]; other site 927666000117 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 927666000118 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 927666000119 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 927666000120 dimerization interface [polypeptide binding]; other site 927666000121 ATP binding site [chemical binding]; other site 927666000122 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 927666000123 dimerization interface [polypeptide binding]; other site 927666000124 ATP binding site [chemical binding]; other site 927666000125 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 927666000126 putative active site [active] 927666000127 catalytic triad [active] 927666000128 amidophosphoribosyltransferase; Provisional; Region: PRK07272 927666000129 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 927666000130 active site 927666000131 tetramer interface [polypeptide binding]; other site 927666000132 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 927666000133 active site 927666000134 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 927666000135 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 927666000136 dimerization interface [polypeptide binding]; other site 927666000137 putative ATP binding site [chemical binding]; other site 927666000138 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 927666000139 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 927666000140 active site 927666000141 substrate binding site [chemical binding]; other site 927666000142 cosubstrate binding site; other site 927666000143 catalytic site [active] 927666000144 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 927666000145 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 927666000146 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 927666000147 purine monophosphate binding site [chemical binding]; other site 927666000148 dimer interface [polypeptide binding]; other site 927666000149 putative catalytic residues [active] 927666000150 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 927666000151 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 927666000152 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 927666000153 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 927666000154 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 927666000155 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 927666000156 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 927666000157 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 927666000158 ATP-grasp domain; Region: ATP-grasp; pfam02222 927666000159 AIPR protein; Region: AIPR; pfam10592 927666000160 adenylosuccinate lyase; Provisional; Region: PRK07492 927666000161 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 927666000162 tetramer interface [polypeptide binding]; other site 927666000163 active site 927666000164 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 927666000165 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 927666000166 N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525 927666000167 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 927666000168 active site 927666000169 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 927666000170 active site 927666000171 G5 domain; Region: G5; pfam07501 927666000172 G5 domain; Region: G5; pfam07501 927666000173 G5 domain; Region: G5; pfam07501 927666000174 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 927666000175 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 927666000176 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 927666000177 DNA-binding site [nucleotide binding]; DNA binding site 927666000178 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 927666000179 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 927666000180 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 927666000181 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 927666000182 active site 927666000183 phosphorylation site [posttranslational modification] 927666000184 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 927666000185 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 927666000186 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 927666000187 active pocket/dimerization site; other site 927666000188 active site 927666000189 phosphorylation site [posttranslational modification] 927666000190 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 927666000191 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 927666000192 dimer interface [polypeptide binding]; other site 927666000193 active site 927666000194 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 927666000195 putative active site [active] 927666000196 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 927666000197 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 927666000198 active site 927666000199 catalytic residues [active] 927666000200 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 927666000201 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 927666000202 putative metal binding site [ion binding]; other site 927666000203 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 927666000204 active site 927666000205 Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169 927666000206 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 927666000207 putative homodimer interface [polypeptide binding]; other site 927666000208 putative homotetramer interface [polypeptide binding]; other site 927666000209 putative metal binding site [ion binding]; other site 927666000210 putative homodimer-homodimer interface [polypeptide binding]; other site 927666000211 putative allosteric switch controlling residues; other site 927666000212 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 927666000213 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 927666000214 active site residue [active] 927666000215 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 927666000216 active site residue [active] 927666000217 maltose O-acetyltransferase; Provisional; Region: PRK10092 927666000218 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 927666000219 active site 927666000220 substrate binding site [chemical binding]; other site 927666000221 trimer interface [polypeptide binding]; other site 927666000222 CoA binding site [chemical binding]; other site 927666000223 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 927666000224 putative metal binding residues [ion binding]; other site 927666000225 signature motif; other site 927666000226 dimer interface [polypeptide binding]; other site 927666000227 active site 927666000228 polyP binding site; other site 927666000229 substrate binding site [chemical binding]; other site 927666000230 acceptor-phosphate pocket; other site 927666000231 Domain of unknown function (DUF4353); Region: DUF4353; pfam14262 927666000232 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 927666000233 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 927666000234 Walker A/P-loop; other site 927666000235 ATP binding site [chemical binding]; other site 927666000236 Q-loop/lid; other site 927666000237 ABC transporter signature motif; other site 927666000238 Walker B; other site 927666000239 D-loop; other site 927666000240 H-loop/switch region; other site 927666000241 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 927666000242 ABC-2 type transporter; Region: ABC2_membrane; cl17235 927666000243 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 927666000244 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 927666000245 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 927666000246 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 927666000247 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 927666000248 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 927666000249 TrkA-N domain; Region: TrkA_N; pfam02254 927666000250 TrkA-C domain; Region: TrkA_C; pfam02080 927666000251 Fibronectin-binding repeat; Region: SSURE; pfam11966 927666000252 Fibronectin-binding repeat; Region: SSURE; pfam11966 927666000253 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 927666000254 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 927666000255 active site 927666000256 phosphorylation site [posttranslational modification] 927666000257 intermolecular recognition site; other site 927666000258 dimerization interface [polypeptide binding]; other site 927666000259 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 927666000260 DNA binding site [nucleotide binding] 927666000261 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 927666000262 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 927666000263 dimerization interface [polypeptide binding]; other site 927666000264 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 927666000265 dimer interface [polypeptide binding]; other site 927666000266 phosphorylation site [posttranslational modification] 927666000267 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 927666000268 ATP binding site [chemical binding]; other site 927666000269 Mg2+ binding site [ion binding]; other site 927666000270 G-X-G motif; other site 927666000271 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 927666000272 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 927666000273 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 927666000274 RNA binding surface [nucleotide binding]; other site 927666000275 truncation; prophage Sa05, site-specific recombinase phage integrase family protein 927666000276 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 927666000277 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 927666000278 Walker A motif; other site 927666000279 ATP binding site [chemical binding]; other site 927666000280 Walker B motif; other site 927666000281 arginine finger; other site 927666000282 Protein of unknown function with HXXEE motif; Region: HXXEE; pfam13787 927666000283 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 927666000284 prophage relict 927666000285 Replication initiation factor; Region: Rep_trans; pfam02486 927666000286 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 927666000287 Int/Topo IB signature motif; other site 927666000288 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 927666000289 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 927666000290 6-phosphogluconate dehydratase; Region: edd; TIGR01196 927666000291 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 927666000292 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 927666000293 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 927666000294 non-specific DNA binding site [nucleotide binding]; other site 927666000295 salt bridge; other site 927666000296 sequence-specific DNA binding site [nucleotide binding]; other site 927666000297 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 927666000298 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 927666000299 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 927666000300 dimer interface [polypeptide binding]; other site 927666000301 motif 1; other site 927666000302 active site 927666000303 motif 2; other site 927666000304 motif 3; other site 927666000305 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 927666000306 anticodon binding site; other site 927666000307 CAAX protease self-immunity; Region: Abi; pfam02517 927666000308 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 927666000309 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 927666000310 dimer interface [polypeptide binding]; other site 927666000311 anticodon binding site; other site 927666000312 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 927666000313 homodimer interface [polypeptide binding]; other site 927666000314 motif 1; other site 927666000315 active site 927666000316 motif 2; other site 927666000317 GAD domain; Region: GAD; pfam02938 927666000318 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 927666000319 motif 3; other site 927666000320 Uncharacterized conserved protein [Function unknown]; Region: COG1284 927666000321 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 927666000322 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 927666000323 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 927666000324 Transcriptional regulators [Transcription]; Region: PurR; COG1609 927666000325 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 927666000326 DNA binding site [nucleotide binding] 927666000327 domain linker motif; other site 927666000328 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 927666000329 putative dimerization interface [polypeptide binding]; other site 927666000330 putative ligand binding site [chemical binding]; other site 927666000331 Predicted integral membrane protein [Function unknown]; Region: COG5521 927666000332 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 927666000333 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 927666000334 dimer interface [polypeptide binding]; other site 927666000335 conserved gate region; other site 927666000336 putative PBP binding loops; other site 927666000337 ABC-ATPase subunit interface; other site 927666000338 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 927666000339 dimer interface [polypeptide binding]; other site 927666000340 conserved gate region; other site 927666000341 putative PBP binding loops; other site 927666000342 ABC-ATPase subunit interface; other site 927666000343 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 927666000344 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 927666000345 4-alpha-glucanotransferase; Provisional; Region: PRK14508 927666000346 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 927666000347 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 927666000348 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 927666000349 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 927666000350 S-adenosylmethionine binding site [chemical binding]; other site 927666000351 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 927666000352 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 927666000353 active site 927666000354 HIGH motif; other site 927666000355 dimer interface [polypeptide binding]; other site 927666000356 KMSKS motif; other site 927666000357 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 927666000358 RNA binding surface [nucleotide binding]; other site 927666000359 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 927666000360 Transglycosylase; Region: Transgly; pfam00912 927666000361 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 927666000362 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 927666000363 EamA-like transporter family; Region: EamA; pfam00892 927666000364 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 927666000365 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 927666000366 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 927666000367 trimer interface [polypeptide binding]; other site 927666000368 active site 927666000369 substrate binding site [chemical binding]; other site 927666000370 CoA binding site [chemical binding]; other site 927666000371 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 927666000372 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 927666000373 metal binding site [ion binding]; metal-binding site 927666000374 putative dimer interface [polypeptide binding]; other site 927666000375 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 927666000376 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 927666000377 Rhomboid family; Region: Rhomboid; pfam01694 927666000378 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 927666000379 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 927666000380 active site 927666000381 tetramer interface; other site 927666000382 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 927666000383 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 927666000384 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 927666000385 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 927666000386 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 927666000387 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 927666000388 Walker A/P-loop; other site 927666000389 ATP binding site [chemical binding]; other site 927666000390 Q-loop/lid; other site 927666000391 ABC transporter signature motif; other site 927666000392 Walker B; other site 927666000393 D-loop; other site 927666000394 H-loop/switch region; other site 927666000395 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 927666000396 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 927666000397 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 927666000398 Walker A/P-loop; other site 927666000399 ATP binding site [chemical binding]; other site 927666000400 Q-loop/lid; other site 927666000401 ABC transporter signature motif; other site 927666000402 Walker B; other site 927666000403 D-loop; other site 927666000404 H-loop/switch region; other site 927666000405 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 927666000406 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 927666000407 catalytic triad [active] 927666000408 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 927666000409 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 927666000410 active site 927666000411 dimer interface [polypeptide binding]; other site 927666000412 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 927666000413 dimer interface [polypeptide binding]; other site 927666000414 active site 927666000415 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 927666000416 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 927666000417 active site 927666000418 HIGH motif; other site 927666000419 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 927666000420 active site 927666000421 KMSKS motif; other site 927666000422 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 927666000423 active site 927666000424 catalytic motif [active] 927666000425 Zn binding site [ion binding]; other site 927666000426 Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954 927666000427 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 927666000428 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 927666000429 pyridoxal 5'-phosphate binding site [chemical binding]; other site 927666000430 catalytic residue [active] 927666000431 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 927666000432 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 927666000433 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 927666000434 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 927666000435 motif II; other site 927666000436 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 927666000437 Transcriptional regulators [Transcription]; Region: MarR; COG1846 927666000438 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 927666000439 putative DNA binding site [nucleotide binding]; other site 927666000440 putative Zn2+ binding site [ion binding]; other site 927666000441 Predicted membrane protein [Function unknown]; Region: COG3759 927666000442 Protein of unknown function (DUF975); Region: DUF975; pfam06161 927666000443 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 927666000444 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 927666000445 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 927666000446 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 927666000447 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 927666000448 catalytic triad [active] 927666000449 catalytic triad [active] 927666000450 oxyanion hole [active] 927666000451 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 927666000452 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 927666000453 active site 927666000454 dimer interface [polypeptide binding]; other site 927666000455 Protein of unknown function (DUF1033); Region: DUF1033; pfam06279 927666000456 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 927666000457 Walker A motif; other site 927666000458 ATP binding site [chemical binding]; other site 927666000459 Walker B motif; other site 927666000460 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 927666000461 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 927666000462 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 927666000463 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 927666000464 Type II secretory pathway pseudopilin; Region: PulG; pfam11773 927666000465 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 927666000466 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 927666000467 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 927666000468 Putative methyltransferase; Region: Methyltransf_4; cl17290 927666000469 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 927666000470 S-adenosylmethionine binding site [chemical binding]; other site 927666000471 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 927666000472 propionate/acetate kinase; Provisional; Region: PRK12379 927666000473 ribonuclease P; Reviewed; Region: rnpA; PRK00499 927666000474 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 927666000475 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 927666000476 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 927666000477 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 927666000478 G-X-X-G motif; other site 927666000479 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 927666000480 RxxxH motif; other site 927666000481 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 927666000482 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 927666000483 TPP-binding site [chemical binding]; other site 927666000484 dimer interface [polypeptide binding]; other site 927666000485 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 927666000486 PYR/PP interface [polypeptide binding]; other site 927666000487 dimer interface [polypeptide binding]; other site 927666000488 TPP binding site [chemical binding]; other site 927666000489 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 927666000490 preprotein translocase subunit YajC; Validated; Region: yajC; PRK06531 927666000491 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 927666000492 Low molecular weight phosphatase family; Region: LMWPc; cd00115 927666000493 active site 927666000494 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 927666000495 MORN repeat; Region: MORN; cl14787 927666000496 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 927666000497 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 927666000498 putative catalytic cysteine [active] 927666000499 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 927666000500 putative active site [active] 927666000501 metal binding site [ion binding]; metal-binding site 927666000502 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 927666000503 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 927666000504 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 927666000505 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 927666000506 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 927666000507 active site 927666000508 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 927666000509 Transglycosylase; Region: Transgly; pfam00912 927666000510 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 927666000511 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 927666000512 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 927666000513 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 927666000514 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 927666000515 putative homodimer interface [polypeptide binding]; other site 927666000516 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 927666000517 heterodimer interface [polypeptide binding]; other site 927666000518 homodimer interface [polypeptide binding]; other site 927666000519 DNA polymerase III PolC; Validated; Region: polC; PRK00448 927666000520 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 927666000521 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 927666000522 generic binding surface II; other site 927666000523 generic binding surface I; other site 927666000524 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 927666000525 active site 927666000526 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 927666000527 active site 927666000528 catalytic site [active] 927666000529 substrate binding site [chemical binding]; other site 927666000530 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 927666000531 putative PHP Thumb interface [polypeptide binding]; other site 927666000532 active site 927666000533 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 927666000534 AAA domain; Region: AAA_22; pfam13401 927666000535 Walker A motif; other site 927666000536 ATP binding site [chemical binding]; other site 927666000537 Walker B motif; other site 927666000538 arginine finger; other site 927666000539 Predicted transcriptional regulator [Transcription]; Region: COG2378 927666000540 HTH domain; Region: HTH_11; cl17392 927666000541 WYL domain; Region: WYL; pfam13280 927666000542 Protein of unknown function DUF262; Region: DUF262; pfam03235 927666000543 Uncharacterized conserved protein [Function unknown]; Region: COG1479 927666000544 Protein of unknown function DUF262; Region: DUF262; pfam03235 927666000545 Uncharacterized conserved protein [Function unknown]; Region: COG1479 927666000546 Protein of unknown function DUF262; Region: DUF262; pfam03235 927666000547 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 927666000548 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 927666000549 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 927666000550 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 927666000551 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 927666000552 RNA binding surface [nucleotide binding]; other site 927666000553 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 927666000554 active site 927666000555 uracil binding [chemical binding]; other site 927666000556 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 927666000557 trimer interface [polypeptide binding]; other site 927666000558 active site 927666000559 G bulge; other site 927666000560 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 927666000561 ATPase, P-type (transporting), HAD superfamily, subfamily IC; Region: ATPase_P-type; TIGR01494 927666000562 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 927666000563 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 927666000564 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 927666000565 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 927666000566 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 927666000567 active pocket/dimerization site; other site 927666000568 active site 927666000569 phosphorylation site [posttranslational modification] 927666000570 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 927666000571 active site 927666000572 phosphorylation site [posttranslational modification] 927666000573 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 927666000574 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 927666000575 active site 927666000576 motif I; other site 927666000577 motif II; other site 927666000578 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 927666000579 CAAX protease self-immunity; Region: Abi; pfam02517 927666000580 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 927666000581 dihydropteroate synthase; Region: DHPS; TIGR01496 927666000582 substrate binding pocket [chemical binding]; other site 927666000583 dimer interface [polypeptide binding]; other site 927666000584 inhibitor binding site; inhibition site 927666000585 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 927666000586 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 927666000587 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 927666000588 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 927666000589 homodecamer interface [polypeptide binding]; other site 927666000590 GTP cyclohydrolase I; Provisional; Region: PLN03044 927666000591 active site 927666000592 putative catalytic site residues [active] 927666000593 zinc binding site [ion binding]; other site 927666000594 GTP-CH-I/GFRP interaction surface; other site 927666000595 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 927666000596 homooctamer interface [polypeptide binding]; other site 927666000597 active site 927666000598 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 927666000599 catalytic center binding site [active] 927666000600 ATP binding site [chemical binding]; other site 927666000601 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 927666000602 catabolite control protein A; Region: ccpA; TIGR01481 927666000603 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 927666000604 DNA binding site [nucleotide binding] 927666000605 domain linker motif; other site 927666000606 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 927666000607 dimerization interface [polypeptide binding]; other site 927666000608 effector binding site; other site 927666000609 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 927666000610 active site 927666000611 homotetramer interface [polypeptide binding]; other site 927666000612 homodimer interface [polypeptide binding]; other site 927666000613 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 927666000614 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 927666000615 active site 927666000616 motif I; other site 927666000617 motif II; other site 927666000618 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 927666000619 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4696 927666000620 metal binding site [ion binding]; metal-binding site 927666000621 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 927666000622 Ligand Binding Site [chemical binding]; other site 927666000623 aminotransferase AlaT; Validated; Region: PRK09265 927666000624 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 927666000625 pyridoxal 5'-phosphate binding site [chemical binding]; other site 927666000626 homodimer interface [polypeptide binding]; other site 927666000627 catalytic residue [active] 927666000628 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 927666000629 Amino acid permease; Region: AA_permease_2; pfam13520 927666000630 K+ potassium transporter; Region: K_trans; cl15781 927666000631 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 927666000632 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 927666000633 active site 927666000634 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 927666000635 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 927666000636 putative active site [active] 927666000637 putative metal binding site [ion binding]; other site 927666000638 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 927666000639 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 927666000640 short chain dehydrogenase; Provisional; Region: PRK06197 927666000641 NAD(P) binding site [chemical binding]; other site 927666000642 active site 927666000643 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 927666000644 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 927666000645 S-adenosylmethionine binding site [chemical binding]; other site 927666000646 GTPase RsgA; Reviewed; Region: PRK00098 927666000647 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 927666000648 RNA binding site [nucleotide binding]; other site 927666000649 homodimer interface [polypeptide binding]; other site 927666000650 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 927666000651 GTPase/Zn-binding domain interface [polypeptide binding]; other site 927666000652 GTP/Mg2+ binding site [chemical binding]; other site 927666000653 G4 box; other site 927666000654 G5 box; other site 927666000655 G1 box; other site 927666000656 Switch I region; other site 927666000657 G2 box; other site 927666000658 G3 box; other site 927666000659 Switch II region; other site 927666000660 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 927666000661 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 927666000662 substrate binding site [chemical binding]; other site 927666000663 hexamer interface [polypeptide binding]; other site 927666000664 metal binding site [ion binding]; metal-binding site 927666000665 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 927666000666 Thiamine pyrophosphokinase; Region: TPK; cd07995 927666000667 active site 927666000668 dimerization interface [polypeptide binding]; other site 927666000669 thiamine binding site [chemical binding]; other site 927666000670 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 927666000671 RmuC family; Region: RmuC; pfam02646 927666000672 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 927666000673 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 927666000674 generic binding surface II; other site 927666000675 generic binding surface I; other site 927666000676 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 927666000677 Zn2+ binding site [ion binding]; other site 927666000678 Mg2+ binding site [ion binding]; other site 927666000679 pur operon repressor; Provisional; Region: PRK09213 927666000680 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 927666000681 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 927666000682 active site 927666000683 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 927666000684 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 927666000685 active site 927666000686 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 927666000687 substrate binding site [chemical binding]; other site 927666000688 catalytic residues [active] 927666000689 dimer interface [polypeptide binding]; other site 927666000690 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 927666000691 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 927666000692 FeS/SAM binding site; other site 927666000693 OxaA-like protein precursor; Provisional; Region: PRK02463 927666000694 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 927666000695 acylphosphatase; Provisional; Region: PRK14434 927666000696 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 927666000697 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 927666000698 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 927666000699 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 927666000700 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 927666000701 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 927666000702 dimer interface [polypeptide binding]; other site 927666000703 active site 927666000704 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 927666000705 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 927666000706 S-adenosylmethionine binding site [chemical binding]; other site 927666000707 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 927666000708 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 927666000709 active site 927666000710 (T/H)XGH motif; other site 927666000711 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 927666000712 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 927666000713 protein binding site [polypeptide binding]; other site 927666000714 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 927666000715 Protein of unknown function (DUF1146); Region: DUF1146; pfam06612 927666000716 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 927666000717 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 927666000718 hinge; other site 927666000719 active site 927666000720 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 927666000721 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 927666000722 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; pfam01223 927666000723 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 927666000724 Domain of unknown function DUF21; Region: DUF21; pfam01595 927666000725 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 927666000726 Transporter associated domain; Region: CorC_HlyC; smart01091 927666000727 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 927666000728 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 927666000729 peptide binding site [polypeptide binding]; other site 927666000730 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 927666000731 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 927666000732 dimer interface [polypeptide binding]; other site 927666000733 conserved gate region; other site 927666000734 putative PBP binding loops; other site 927666000735 ABC-ATPase subunit interface; other site 927666000736 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 927666000737 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 927666000738 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 927666000739 dimer interface [polypeptide binding]; other site 927666000740 conserved gate region; other site 927666000741 putative PBP binding loops; other site 927666000742 ABC-ATPase subunit interface; other site 927666000743 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 927666000744 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 927666000745 Walker A/P-loop; other site 927666000746 ATP binding site [chemical binding]; other site 927666000747 Q-loop/lid; other site 927666000748 ABC transporter signature motif; other site 927666000749 Walker B; other site 927666000750 D-loop; other site 927666000751 H-loop/switch region; other site 927666000752 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 927666000753 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 927666000754 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 927666000755 Walker A/P-loop; other site 927666000756 ATP binding site [chemical binding]; other site 927666000757 Q-loop/lid; other site 927666000758 ABC transporter signature motif; other site 927666000759 Walker B; other site 927666000760 D-loop; other site 927666000761 H-loop/switch region; other site 927666000762 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 927666000763 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 927666000764 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 927666000765 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 927666000766 TrkA-N domain; Region: TrkA_N; pfam02254 927666000767 TrkA-C domain; Region: TrkA_C; pfam02080 927666000768 TrkA-N domain; Region: TrkA_N; pfam02254 927666000769 TrkA-C domain; Region: TrkA_C; pfam02080 927666000770 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 927666000771 Predicted membrane protein [Function unknown]; Region: COG3601 927666000772 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 927666000773 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 927666000774 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 927666000775 active site 927666000776 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 927666000777 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 927666000778 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 927666000779 dimer interface [polypeptide binding]; other site 927666000780 motif 1; other site 927666000781 active site 927666000782 motif 2; other site 927666000783 motif 3; other site 927666000784 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 927666000785 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 927666000786 Coenzyme A binding pocket [chemical binding]; other site 927666000787 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 927666000788 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 927666000789 putative tRNA-binding site [nucleotide binding]; other site 927666000790 B3/4 domain; Region: B3_4; pfam03483 927666000791 tRNA synthetase B5 domain; Region: B5; smart00874 927666000792 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 927666000793 dimer interface [polypeptide binding]; other site 927666000794 motif 1; other site 927666000795 motif 3; other site 927666000796 motif 2; other site 927666000797 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 927666000798 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 927666000799 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 927666000800 Walker A/P-loop; other site 927666000801 ATP binding site [chemical binding]; other site 927666000802 Q-loop/lid; other site 927666000803 ABC transporter signature motif; other site 927666000804 Walker B; other site 927666000805 D-loop; other site 927666000806 H-loop/switch region; other site 927666000807 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 927666000808 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 927666000809 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 927666000810 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 927666000811 Predicted membrane protein [Function unknown]; Region: COG4709 927666000812 Predicted transcriptional regulators [Transcription]; Region: COG1695 927666000813 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 927666000814 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 927666000815 23S rRNA interface [nucleotide binding]; other site 927666000816 L3 interface [polypeptide binding]; other site 927666000817 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 927666000818 Transcriptional regulator [Transcription]; Region: LysR; COG0583 927666000819 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 927666000820 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 927666000821 dimerization interface [polypeptide binding]; other site 927666000822 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 927666000823 sequence-specific DNA binding site [nucleotide binding]; other site 927666000824 salt bridge; other site 927666000825 malate dehydrogenase; Provisional; Region: PRK13529 927666000826 Malic enzyme, N-terminal domain; Region: malic; pfam00390 927666000827 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 927666000828 NAD(P) binding site [chemical binding]; other site 927666000829 Membrane transport protein; Region: Mem_trans; cl09117 927666000830 WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930 927666000831 type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929 927666000832 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 927666000833 type VII secretion protein EssA; Region: T7SS_EssA_Firm; TIGR03927 927666000834 YukD; Region: YukD; cl11566 927666000835 type VII secretion protein EssB; Region: T7_EssB; TIGR03926 927666000836 WXG100 protein secretion system (Wss), protein YukC; Region: YukC; pfam10140 927666000837 DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538 927666000838 Protein of unknown function, DUF484; Region: DUF484; cl17449 927666000839 type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928 927666000840 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 927666000841 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 927666000842 Walker A motif; other site 927666000843 ATP binding site [chemical binding]; other site 927666000844 Domain of unknown function (DUF4176); Region: DUF4176; cl01867 927666000845 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 927666000846 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 927666000847 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 927666000848 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 927666000849 Walker A/P-loop; other site 927666000850 ATP binding site [chemical binding]; other site 927666000851 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 927666000852 ABC transporter signature motif; other site 927666000853 Walker B; other site 927666000854 D-loop; other site 927666000855 H-loop/switch region; other site 927666000856 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 927666000857 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 927666000858 sequence-specific DNA binding site [nucleotide binding]; other site 927666000859 salt bridge; other site 927666000860 Predicted transcriptional regulator [Transcription]; Region: COG2932 927666000861 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 927666000862 Catalytic site [active] 927666000863 DNA polymerase IV; Reviewed; Region: PRK03103 927666000864 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 927666000865 active site 927666000866 DNA binding site [nucleotide binding] 927666000867 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 927666000868 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 927666000869 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 927666000870 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 927666000871 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 927666000872 Calx-beta domain; Region: Calx-beta; cl02522 927666000873 G5 domain; Region: G5; pfam07501 927666000874 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 927666000875 catalytic residues [active] 927666000876 dimer interface [polypeptide binding]; other site 927666000877 LXG domain of WXG superfamily; Region: LXG; pfam04740 927666000878 Protein of unknown function (DUF3278); Region: DUF3278; pfam11683 927666000879 Protein of unknown function (DUF3278); Region: DUF3278; pfam11683 927666000880 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 927666000881 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 927666000882 non-specific DNA binding site [nucleotide binding]; other site 927666000883 salt bridge; other site 927666000884 sequence-specific DNA binding site [nucleotide binding]; other site 927666000885 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 927666000886 MraW methylase family; Region: Methyltransf_5; pfam01795 927666000887 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 927666000888 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 927666000889 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 927666000890 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 927666000891 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 927666000892 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 927666000893 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 927666000894 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 927666000895 Mg++ binding site [ion binding]; other site 927666000896 putative catalytic motif [active] 927666000897 putative substrate binding site [chemical binding]; other site 927666000898 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 927666000899 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 927666000900 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 927666000901 Interdomain contacts; other site 927666000902 Cytokine receptor motif; other site 927666000903 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 927666000904 glutamate racemase; Provisional; Region: PRK00865 927666000905 putative deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein; Reviewed; Region: PRK02491 927666000906 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 927666000907 active site 927666000908 dimerization interface [polypeptide binding]; other site 927666000909 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 927666000910 active site 927666000911 metal binding site [ion binding]; metal-binding site 927666000912 homotetramer interface [polypeptide binding]; other site 927666000913 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 927666000914 FOG: CBS domain [General function prediction only]; Region: COG0517 927666000915 site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436 927666000916 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 927666000917 DNA binding site [nucleotide binding] 927666000918 Int/Topo IB signature motif; other site 927666000919 active site 927666000920 catalytic residues [active] 927666000921 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 927666000922 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 927666000923 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 927666000924 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 927666000925 RNA binding surface [nucleotide binding]; other site 927666000926 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 927666000927 active site 927666000928 hypothetical protein; Validated; Region: PRK00041 927666000929 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 927666000930 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 927666000931 oligomer interface [polypeptide binding]; other site 927666000932 active site 927666000933 metal binding site [ion binding]; metal-binding site 927666000934 Enterocin A Immunity; Region: EntA_Immun; pfam08951 927666000935 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 927666000936 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 927666000937 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 927666000938 PhoU domain; Region: PhoU; pfam01895 927666000939 PhoU domain; Region: PhoU; pfam01895 927666000940 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 927666000941 Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724 927666000942 Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with...; Region: GH85_ENGase; cd06547 927666000943 putative active site [active] 927666000944 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 927666000945 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 927666000946 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 927666000947 G5 domain; Region: G5; pfam07501 927666000948 G5 domain; Region: G5; pfam07501 927666000949 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 927666000950 SnoaL-like domain; Region: SnoaL_2; pfam12680 927666000951 Predicted transcriptional regulator [Transcription]; Region: COG2378 927666000952 HTH domain; Region: HTH_11; pfam08279 927666000953 WYL domain; Region: WYL; pfam13280 927666000954 Phosphoglycerate kinase; Region: PGK; pfam00162 927666000955 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 927666000956 substrate binding site [chemical binding]; other site 927666000957 hinge regions; other site 927666000958 ADP binding site [chemical binding]; other site 927666000959 catalytic site [active] 927666000960 putative cross-wall-targeting lipoprotein signal; Region: strep_RK_lipo; TIGR03726 927666000961 Streptococcal surface antigen repeat; Region: Strep_SA_rep; pfam06696 927666000962 Streptococcal surface antigen repeat; Region: Strep_SA_rep; pfam06696 927666000963 Streptococcal surface antigen repeat; Region: Strep_SA_rep; pfam06696 927666000964 Glucan-binding protein C; Region: GbpC; pfam08363 927666000965 adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228 927666000966 Predicted membrane protein [Function unknown]; Region: COG4129 927666000967 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 927666000968 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 927666000969 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 927666000970 DNA binding residues [nucleotide binding] 927666000971 putative dimer interface [polypeptide binding]; other site 927666000972 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 927666000973 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 927666000974 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 927666000975 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 927666000976 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 927666000977 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 927666000978 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 927666000979 GrpE; Region: GrpE; pfam01025 927666000980 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 927666000981 dimer interface [polypeptide binding]; other site 927666000982 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 927666000983 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 927666000984 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 927666000985 nucleotide binding site [chemical binding]; other site 927666000986 NEF interaction site [polypeptide binding]; other site 927666000987 SBD interface [polypeptide binding]; other site 927666000988 chaperone protein DnaJ; Provisional; Region: PRK14276 927666000989 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 927666000990 HSP70 interaction site [polypeptide binding]; other site 927666000991 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 927666000992 substrate binding site [polypeptide binding]; other site 927666000993 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 927666000994 Zn binding sites [ion binding]; other site 927666000995 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 927666000996 dimer interface [polypeptide binding]; other site 927666000997 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 927666000998 HIT family signature motif; other site 927666000999 catalytic residue [active] 927666001000 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 927666001001 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 927666001002 Walker A/P-loop; other site 927666001003 ATP binding site [chemical binding]; other site 927666001004 Q-loop/lid; other site 927666001005 ABC transporter signature motif; other site 927666001006 Walker B; other site 927666001007 D-loop; other site 927666001008 H-loop/switch region; other site 927666001009 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 927666001010 Phosphotransferase enzyme family; Region: APH; pfam01636 927666001011 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 927666001012 substrate binding site [chemical binding]; other site 927666001013 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 927666001014 S-adenosylmethionine binding site [chemical binding]; other site 927666001015 ribosome maturation protein RimP; Reviewed; Region: PRK00092 927666001016 Sm and related proteins; Region: Sm_like; cl00259 927666001017 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 927666001018 putative oligomer interface [polypeptide binding]; other site 927666001019 putative RNA binding site [nucleotide binding]; other site 927666001020 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 927666001021 NusA N-terminal domain; Region: NusA_N; pfam08529 927666001022 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 927666001023 RNA binding site [nucleotide binding]; other site 927666001024 homodimer interface [polypeptide binding]; other site 927666001025 NusA-like KH domain; Region: KH_5; pfam13184 927666001026 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 927666001027 G-X-X-G motif; other site 927666001028 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 927666001029 putative RNA binding cleft [nucleotide binding]; other site 927666001030 hypothetical protein; Provisional; Region: PRK07283 927666001031 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 927666001032 translation initiation factor IF-2; Region: IF-2; TIGR00487 927666001033 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 927666001034 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 927666001035 G1 box; other site 927666001036 putative GEF interaction site [polypeptide binding]; other site 927666001037 GTP/Mg2+ binding site [chemical binding]; other site 927666001038 Switch I region; other site 927666001039 G2 box; other site 927666001040 G3 box; other site 927666001041 Switch II region; other site 927666001042 G4 box; other site 927666001043 G5 box; other site 927666001044 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 927666001045 Translation-initiation factor 2; Region: IF-2; pfam11987 927666001046 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 927666001047 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 927666001048 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 927666001049 Uncharacterized conserved protein [Function unknown]; Region: COG2461 927666001050 Family of unknown function (DUF438); Region: DUF438; pfam04282 927666001051 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 927666001052 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 927666001053 putative active site [active] 927666001054 heme pocket [chemical binding]; other site 927666001055 Domain of unknown function (DUF1912); Region: DUF1912; pfam08930 927666001056 hypothetical protein; Provisional; Region: PRK07758 927666001057 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 927666001058 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 927666001059 Part of AAA domain; Region: AAA_19; pfam13245 927666001060 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 927666001061 hypothetical protein; Region: PHA00727 927666001062 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 927666001063 AAA domain; Region: AAA_12; pfam13087 927666001064 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 927666001065 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 927666001066 active site 927666001067 HIGH motif; other site 927666001068 nucleotide binding site [chemical binding]; other site 927666001069 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 927666001070 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 927666001071 active site 927666001072 KMSKS motif; other site 927666001073 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 927666001074 tRNA binding surface [nucleotide binding]; other site 927666001075 anticodon binding site; other site 927666001076 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 927666001077 sporadically distributed protein, TIGR04141 family; Region: TIGR04141 927666001078 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 927666001079 CTP synthetase; Validated; Region: pyrG; PRK05380 927666001080 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 927666001081 Catalytic site [active] 927666001082 active site 927666001083 UTP binding site [chemical binding]; other site 927666001084 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 927666001085 active site 927666001086 putative oxyanion hole; other site 927666001087 catalytic triad [active] 927666001088 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 927666001089 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 927666001090 catalytic residues [active] 927666001091 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 927666001092 putative tRNA-binding site [nucleotide binding]; other site 927666001093 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 927666001094 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 927666001095 NAD(P) binding site [chemical binding]; other site 927666001096 active site 927666001097 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 927666001098 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 927666001099 dimer interface [polypeptide binding]; other site 927666001100 ssDNA binding site [nucleotide binding]; other site 927666001101 tetramer (dimer of dimers) interface [polypeptide binding]; other site 927666001102 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 927666001103 oligomerisation interface [polypeptide binding]; other site 927666001104 mobile loop; other site 927666001105 roof hairpin; other site 927666001106 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 927666001107 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 927666001108 ring oligomerisation interface [polypeptide binding]; other site 927666001109 ATP/Mg binding site [chemical binding]; other site 927666001110 stacking interactions; other site 927666001111 hinge regions; other site 927666001112 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 927666001113 hypothetical protein; Provisional; Region: PRK13662 927666001114 recombination regulator RecX; Provisional; Region: recX; PRK14135 927666001115 TRAM domain; Region: TRAM; pfam01938 927666001116 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 927666001117 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 927666001118 S-adenosylmethionine binding site [chemical binding]; other site 927666001119 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 927666001120 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 927666001121 DNA-binding site [nucleotide binding]; DNA binding site 927666001122 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 927666001123 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 927666001124 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 927666001125 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 927666001126 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 927666001127 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 927666001128 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 927666001129 Melibiase; Region: Melibiase; pfam02065 927666001130 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 927666001131 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 927666001132 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 927666001133 dimer interface [polypeptide binding]; other site 927666001134 conserved gate region; other site 927666001135 putative PBP binding loops; other site 927666001136 ABC-ATPase subunit interface; other site 927666001137 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 927666001138 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 927666001139 dimer interface [polypeptide binding]; other site 927666001140 conserved gate region; other site 927666001141 putative PBP binding loops; other site 927666001142 ABC-ATPase subunit interface; other site 927666001143 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 927666001144 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 927666001145 active site 927666001146 homodimer interface [polypeptide binding]; other site 927666001147 catalytic site [active] 927666001148 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 927666001149 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 927666001150 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 927666001151 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 927666001152 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 927666001153 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 927666001154 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 927666001155 Walker A/P-loop; other site 927666001156 ATP binding site [chemical binding]; other site 927666001157 Q-loop/lid; other site 927666001158 ABC transporter signature motif; other site 927666001159 Walker B; other site 927666001160 D-loop; other site 927666001161 H-loop/switch region; other site 927666001162 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 927666001163 dimer interface [polypeptide binding]; other site 927666001164 conserved gate region; other site 927666001165 ABC-ATPase subunit interface; other site 927666001166 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 927666001167 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 927666001168 Cobalt transport protein; Region: CbiQ; cl00463 927666001169 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 927666001170 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 927666001171 Walker A/P-loop; other site 927666001172 ATP binding site [chemical binding]; other site 927666001173 Q-loop/lid; other site 927666001174 ABC transporter signature motif; other site 927666001175 Walker B; other site 927666001176 D-loop; other site 927666001177 H-loop/switch region; other site 927666001178 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 927666001179 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 927666001180 Walker A/P-loop; other site 927666001181 ATP binding site [chemical binding]; other site 927666001182 Q-loop/lid; other site 927666001183 ABC transporter signature motif; other site 927666001184 Walker B; other site 927666001185 D-loop; other site 927666001186 H-loop/switch region; other site 927666001187 Integrase core domain; Region: rve; pfam00665 927666001188 Lactococcus lactis RepB C-terminus; Region: L_lactis_RepB_C; pfam06430 927666001189 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 927666001190 nicotinamide mononucleotide transporter PnuC; Region: NMN_trans_PnuC; TIGR01528 927666001191 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 927666001192 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 927666001193 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 927666001194 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 927666001195 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 927666001196 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 927666001197 DNA binding site [nucleotide binding] 927666001198 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 927666001199 putative dimerization interface [polypeptide binding]; other site 927666001200 putative ligand binding site [chemical binding]; other site 927666001201 galactokinase; Provisional; Region: PRK05322 927666001202 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 927666001203 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 927666001204 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 927666001205 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 927666001206 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 927666001207 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 927666001208 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 927666001209 CoenzymeA binding site [chemical binding]; other site 927666001210 subunit interaction site [polypeptide binding]; other site 927666001211 PHB binding site; other site 927666001212 xanthine permease; Region: pbuX; TIGR03173 927666001213 Sulfate transporter family; Region: Sulfate_transp; pfam00916 927666001214 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 927666001215 active site 927666001216 Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349 927666001217 dimer interface [polypeptide binding]; other site 927666001218 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 927666001219 ligand binding site [chemical binding]; other site 927666001220 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 927666001221 active site 927666001222 putative catalytic site [active] 927666001223 DNA binding site [nucleotide binding] 927666001224 putative phosphate binding site [ion binding]; other site 927666001225 metal binding site A [ion binding]; metal-binding site 927666001226 AP binding site [nucleotide binding]; other site 927666001227 metal binding site B [ion binding]; metal-binding site 927666001228 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 927666001229 Predicted membrane protein [Function unknown]; Region: COG2323 927666001230 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 927666001231 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 927666001232 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 927666001233 Walker A/P-loop; other site 927666001234 ATP binding site [chemical binding]; other site 927666001235 Q-loop/lid; other site 927666001236 ABC transporter signature motif; other site 927666001237 Walker B; other site 927666001238 D-loop; other site 927666001239 H-loop/switch region; other site 927666001240 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 927666001241 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 927666001242 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 927666001243 Walker A/P-loop; other site 927666001244 ATP binding site [chemical binding]; other site 927666001245 Q-loop/lid; other site 927666001246 ABC transporter signature motif; other site 927666001247 Walker B; other site 927666001248 D-loop; other site 927666001249 H-loop/switch region; other site 927666001250 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 927666001251 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 927666001252 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 927666001253 inhibitor-cofactor binding pocket; inhibition site 927666001254 pyridoxal 5'-phosphate binding site [chemical binding]; other site 927666001255 catalytic residue [active] 927666001256 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 927666001257 catalytic residue [active] 927666001258 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 927666001259 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 927666001260 anthranilate synthase component I; Provisional; Region: PRK13570 927666001261 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 927666001262 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 927666001263 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 927666001264 Glutamine amidotransferase class-I; Region: GATase; pfam00117 927666001265 glutamine binding [chemical binding]; other site 927666001266 catalytic triad [active] 927666001267 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 927666001268 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 927666001269 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 927666001270 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 927666001271 active site 927666001272 ribulose/triose binding site [chemical binding]; other site 927666001273 phosphate binding site [ion binding]; other site 927666001274 substrate (anthranilate) binding pocket [chemical binding]; other site 927666001275 product (indole) binding pocket [chemical binding]; other site 927666001276 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 927666001277 active site 927666001278 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 927666001279 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 927666001280 pyridoxal 5'-phosphate binding site [chemical binding]; other site 927666001281 catalytic residue [active] 927666001282 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 927666001283 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 927666001284 substrate binding site [chemical binding]; other site 927666001285 active site 927666001286 catalytic residues [active] 927666001287 heterodimer interface [polypeptide binding]; other site 927666001288 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 927666001289 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 927666001290 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 927666001291 pseudaminic acid biosynthesis N-acetyl transferase; Region: PseH; TIGR03585 927666001292 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 927666001293 Coenzyme A binding pocket [chemical binding]; other site 927666001294 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 927666001295 Small integral membrane protein [Function unknown]; Region: COG5547 927666001296 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 927666001297 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 927666001298 Mga helix-turn-helix domain; Region: Mga; pfam05043 927666001299 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 927666001300 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 927666001301 short chain dehydrogenase; Provisional; Region: PRK12746 927666001302 NAD(P) binding site [chemical binding]; other site 927666001303 active site 927666001304 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 927666001305 TAP-like protein; Region: Abhydrolase_4; pfam08386 927666001306 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 927666001307 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 927666001308 putative NAD(P) binding site [chemical binding]; other site 927666001309 Transcriptional regulator; Region: Rrf2; pfam02082 927666001310 Rrf2 family protein; Region: rrf2_super; TIGR00738 927666001311 recombination factor protein RarA; Reviewed; Region: PRK13342 927666001312 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 927666001313 Walker A motif; other site 927666001314 ATP binding site [chemical binding]; other site 927666001315 Walker B motif; other site 927666001316 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 927666001317 arginine finger; other site 927666001318 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 927666001319 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 927666001320 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 927666001321 Peptidase family M50; Region: Peptidase_M50; pfam02163 927666001322 active site 927666001323 putative substrate binding region [chemical binding]; other site 927666001324 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 927666001325 nudix motif; other site 927666001326 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 927666001327 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 927666001328 Coenzyme A binding pocket [chemical binding]; other site 927666001329 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 927666001330 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 927666001331 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 927666001332 S-adenosylmethionine binding site [chemical binding]; other site 927666001333 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 927666001334 RNA methyltransferase, RsmE family; Region: TIGR00046 927666001335 oligoendopeptidase F; Region: pepF; TIGR00181 927666001336 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 927666001337 Zn binding site [ion binding]; other site 927666001338 Protein of unknown function, DUF576; Region: DUF576; cl04553 927666001339 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 927666001340 nucleophilic elbow; other site 927666001341 catalytic triad; other site 927666001342 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 927666001343 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 927666001344 amphipathic channel; other site 927666001345 Asn-Pro-Ala signature motifs; other site 927666001346 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 927666001347 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 927666001348 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 927666001349 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 927666001350 active site 927666001351 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 927666001352 Ligand Binding Site [chemical binding]; other site 927666001353 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 927666001354 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 927666001355 catalytic residues [active] 927666001356 MarR family; Region: MarR_2; pfam12802 927666001357 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 927666001358 LrgB-like family; Region: LrgB; pfam04172 927666001359 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 927666001360 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 927666001361 Walker A/P-loop; other site 927666001362 ATP binding site [chemical binding]; other site 927666001363 Q-loop/lid; other site 927666001364 ABC transporter signature motif; other site 927666001365 Walker B; other site 927666001366 D-loop; other site 927666001367 H-loop/switch region; other site 927666001368 Predicted transcriptional regulators [Transcription]; Region: COG1725 927666001369 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 927666001370 DNA-binding site [nucleotide binding]; DNA binding site 927666001371 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 927666001372 ATP cone domain; Region: ATP-cone; pfam03477 927666001373 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 927666001374 primosomal protein DnaI; Reviewed; Region: PRK08939 927666001375 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 927666001376 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 927666001377 Walker A motif; other site 927666001378 ATP binding site [chemical binding]; other site 927666001379 Walker B motif; other site 927666001380 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 927666001381 dimer interface [polypeptide binding]; other site 927666001382 FMN binding site [chemical binding]; other site 927666001383 NADPH bind site [chemical binding]; other site 927666001384 GTP-binding protein Der; Reviewed; Region: PRK00093 927666001385 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 927666001386 G1 box; other site 927666001387 GTP/Mg2+ binding site [chemical binding]; other site 927666001388 Switch I region; other site 927666001389 G2 box; other site 927666001390 Switch II region; other site 927666001391 G3 box; other site 927666001392 G4 box; other site 927666001393 G5 box; other site 927666001394 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 927666001395 G1 box; other site 927666001396 GTP/Mg2+ binding site [chemical binding]; other site 927666001397 Switch I region; other site 927666001398 G2 box; other site 927666001399 G3 box; other site 927666001400 Switch II region; other site 927666001401 G4 box; other site 927666001402 G5 box; other site 927666001403 Repair protein; Region: Repair_PSII; pfam04536 927666001404 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 927666001405 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 927666001406 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 927666001407 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 927666001408 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 927666001409 nucleotide binding region [chemical binding]; other site 927666001410 ATP-binding site [chemical binding]; other site 927666001411 SEC-C motif; Region: SEC-C; pfam02810 927666001412 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG0722 927666001413 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 927666001414 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; cl17260 927666001415 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 927666001416 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 927666001417 alanine racemase; Reviewed; Region: alr; PRK00053 927666001418 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 927666001419 active site 927666001420 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 927666001421 dimer interface [polypeptide binding]; other site 927666001422 substrate binding site [chemical binding]; other site 927666001423 catalytic residues [active] 927666001424 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 927666001425 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 927666001426 ssDNA binding site; other site 927666001427 generic binding surface II; other site 927666001428 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 927666001429 ATP binding site [chemical binding]; other site 927666001430 putative Mg++ binding site [ion binding]; other site 927666001431 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 927666001432 nucleotide binding region [chemical binding]; other site 927666001433 ATP-binding site [chemical binding]; other site 927666001434 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 927666001435 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 927666001436 Sialidase, N-terminal domain; Region: Sialidase; pfam02973 927666001437 calcium mediated ligand binding site; other site 927666001438 intermolecular salt bridges; other site 927666001439 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 927666001440 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 927666001441 Asp-box motif; other site 927666001442 catalytic site [active] 927666001443 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 927666001444 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 927666001445 putative active site cavity [active] 927666001446 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 927666001447 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 927666001448 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 927666001449 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 927666001450 dimer interface [polypeptide binding]; other site 927666001451 conserved gate region; other site 927666001452 putative PBP binding loops; other site 927666001453 ABC-ATPase subunit interface; other site 927666001454 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 927666001455 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 927666001456 dimer interface [polypeptide binding]; other site 927666001457 conserved gate region; other site 927666001458 putative PBP binding loops; other site 927666001459 ABC-ATPase subunit interface; other site 927666001460 Domain of unknown function (DUF386); Region: DUF386; pfam04074 927666001461 Protein of unknown function, DUF624; Region: DUF624; pfam04854 927666001462 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 927666001463 Class I aldolases; Region: Aldolase_Class_I; cl17187 927666001464 catalytic residue [active] 927666001465 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 927666001466 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 927666001467 nucleotide binding site [chemical binding]; other site 927666001468 Methyltransferase domain; Region: Methyltransf_31; pfam13847 927666001469 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 927666001470 S-adenosylmethionine binding site [chemical binding]; other site 927666001471 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 927666001472 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 927666001473 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 927666001474 putative active site [active] 927666001475 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 927666001476 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 927666001477 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 927666001478 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 927666001479 recombination protein RecR; Reviewed; Region: recR; PRK00076 927666001480 RecR protein; Region: RecR; pfam02132 927666001481 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 927666001482 putative active site [active] 927666001483 putative metal-binding site [ion binding]; other site 927666001484 tetramer interface [polypeptide binding]; other site 927666001485 TraB family; Region: TraB; cl12050 927666001486 LXG domain of WXG superfamily; Region: LXG; pfam04740 927666001487 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 927666001488 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 927666001489 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 927666001490 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 927666001491 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 927666001492 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 927666001493 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 927666001494 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 927666001495 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 927666001496 nudix motif; other site 927666001497 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 927666001498 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 927666001499 Cell division protein FtsA; Region: FtsA; smart00842 927666001500 Cell division protein FtsA; Region: FtsA; pfam14450 927666001501 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 927666001502 cell division protein FtsZ; Validated; Region: PRK09330 927666001503 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 927666001504 nucleotide binding site [chemical binding]; other site 927666001505 SulA interaction site; other site 927666001506 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 927666001507 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 927666001508 catalytic residue [active] 927666001509 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 927666001510 YGGT family; Region: YGGT; pfam02325 927666001511 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 927666001512 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 927666001513 RNA binding surface [nucleotide binding]; other site 927666001514 DivIVA protein; Region: DivIVA; pfam05103 927666001515 DivIVA domain; Region: DivI1A_domain; TIGR03544 927666001516 DivIVA protein; Region: DivIVA; pfam05103 927666001517 DivIVA domain; Region: DivI1A_domain; TIGR03544 927666001518 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 927666001519 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 927666001520 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 927666001521 active site 927666001522 HIGH motif; other site 927666001523 nucleotide binding site [chemical binding]; other site 927666001524 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 927666001525 active site 927666001526 KMSKS motif; other site 927666001527 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 927666001528 tRNA binding surface [nucleotide binding]; other site 927666001529 anticodon binding site; other site 927666001530 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 927666001531 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 927666001532 G5 domain; Region: G5; pfam07501 927666001533 G5 domain; Region: G5; pfam07501 927666001534 G5 domain; Region: G5; pfam07501 927666001535 G5 domain; Region: G5; pfam07501 927666001536 M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342 927666001537 M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580 927666001538 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 927666001539 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 927666001540 G5 domain; Region: G5; pfam07501 927666001541 M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342 927666001542 M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580 927666001543 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 927666001544 catalytic core [active] 927666001545 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 927666001546 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 927666001547 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 927666001548 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 927666001549 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 927666001550 Walker A/P-loop; other site 927666001551 ATP binding site [chemical binding]; other site 927666001552 Q-loop/lid; other site 927666001553 ABC transporter signature motif; other site 927666001554 Walker B; other site 927666001555 D-loop; other site 927666001556 H-loop/switch region; other site 927666001557 FtsX-like permease family; Region: FtsX; pfam02687 927666001558 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 927666001559 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 927666001560 FtsX-like permease family; Region: FtsX; pfam02687 927666001561 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 927666001562 16S/18S rRNA binding site [nucleotide binding]; other site 927666001563 S13e-L30e interaction site [polypeptide binding]; other site 927666001564 25S rRNA binding site [nucleotide binding]; other site 927666001565 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 927666001566 Cadmium resistance transporter; Region: Cad; pfam03596 927666001567 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 927666001568 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 927666001569 ABC-ATPase subunit interface; other site 927666001570 dimer interface [polypeptide binding]; other site 927666001571 putative PBP binding regions; other site 927666001572 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 927666001573 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 927666001574 Walker A/P-loop; other site 927666001575 ATP binding site [chemical binding]; other site 927666001576 Q-loop/lid; other site 927666001577 ABC transporter signature motif; other site 927666001578 Walker B; other site 927666001579 D-loop; other site 927666001580 H-loop/switch region; other site 927666001581 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 927666001582 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 927666001583 intersubunit interface [polypeptide binding]; other site 927666001584 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 927666001585 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 927666001586 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 927666001587 putative acyl-acceptor binding pocket; other site 927666001588 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 927666001589 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 927666001590 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 927666001591 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 927666001592 motif II; other site 927666001593 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 927666001594 Family of unknown function (DUF633); Region: DUF633; pfam04816 927666001595 Uncharacterized conserved protein [Function unknown]; Region: COG0327 927666001596 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 927666001597 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 927666001598 UDP-glucose 4-epimerase; Region: PLN02240 927666001599 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 927666001600 NAD binding site [chemical binding]; other site 927666001601 homodimer interface [polypeptide binding]; other site 927666001602 active site 927666001603 substrate binding site [chemical binding]; other site 927666001604 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 927666001605 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 927666001606 Ligand binding site; other site 927666001607 Putative Catalytic site; other site 927666001608 DXD motif; other site 927666001609 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 927666001610 cytidylate kinase; Provisional; Region: cmk; PRK00023 927666001611 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 927666001612 CMP-binding site; other site 927666001613 The sites determining sugar specificity; other site 927666001614 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 927666001615 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 927666001616 folate binding site [chemical binding]; other site 927666001617 NADP+ binding site [chemical binding]; other site 927666001618 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 927666001619 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 927666001620 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 927666001621 Walker A motif; other site 927666001622 ATP binding site [chemical binding]; other site 927666001623 Walker B motif; other site 927666001624 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 927666001625 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 927666001626 G1 box; other site 927666001627 GTP/Mg2+ binding site [chemical binding]; other site 927666001628 Switch I region; other site 927666001629 G2 box; other site 927666001630 G3 box; other site 927666001631 Switch II region; other site 927666001632 G4 box; other site 927666001633 G5 box; other site 927666001634 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 927666001635 homotrimer interaction site [polypeptide binding]; other site 927666001636 putative active site [active] 927666001637 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 927666001638 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 927666001639 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 927666001640 dimer interface [polypeptide binding]; other site 927666001641 phosphate binding site [ion binding]; other site 927666001642 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 927666001643 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 927666001644 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 927666001645 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 927666001646 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 927666001647 Uncharacterized conserved protein [Function unknown]; Region: COG1624 927666001648 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 927666001649 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 927666001650 YbbR-like protein; Region: YbbR; pfam07949 927666001651 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 927666001652 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 927666001653 active site 927666001654 substrate binding site [chemical binding]; other site 927666001655 metal binding site [ion binding]; metal-binding site 927666001656 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4835 927666001657 EDD domain protein, DegV family; Region: DegV; TIGR00762 927666001658 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 927666001659 dihydrodipicolinate reductase; Provisional; Region: PRK00048 927666001660 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 927666001661 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 927666001662 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 927666001663 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 927666001664 active site 927666001665 NTP binding site [chemical binding]; other site 927666001666 metal binding triad [ion binding]; metal-binding site 927666001667 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 927666001668 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 927666001669 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 927666001670 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 927666001671 Walker A/P-loop; other site 927666001672 ATP binding site [chemical binding]; other site 927666001673 Q-loop/lid; other site 927666001674 ABC transporter signature motif; other site 927666001675 Walker B; other site 927666001676 D-loop; other site 927666001677 H-loop/switch region; other site 927666001678 ABC transporter; Region: ABC_tran_2; pfam12848 927666001679 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 927666001680 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 927666001681 Cation efflux family; Region: Cation_efflux; pfam01545 927666001682 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 927666001683 Acyltransferase family; Region: Acyl_transf_3; pfam01757 927666001684 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 927666001685 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 927666001686 Ligand binding site; other site 927666001687 Putative Catalytic site; other site 927666001688 DXD motif; other site 927666001689 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 927666001690 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 927666001691 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 927666001692 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 927666001693 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 927666001694 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 927666001695 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 927666001696 active site 927666001697 catalytic residues [active] 927666001698 metal binding site [ion binding]; metal-binding site 927666001699 hypothetical protein; Validated; Region: PRK02101 927666001700 Predicted flavoprotein [General function prediction only]; Region: COG0431 927666001701 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 927666001702 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 927666001703 MarR family; Region: MarR; pfam01047 927666001704 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 927666001705 aspartate aminotransferase; Provisional; Region: PRK05764 927666001706 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 927666001707 pyridoxal 5'-phosphate binding site [chemical binding]; other site 927666001708 homodimer interface [polypeptide binding]; other site 927666001709 catalytic residue [active] 927666001710 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 927666001711 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 927666001712 putative dimer interface [polypeptide binding]; other site 927666001713 putative anticodon binding site; other site 927666001714 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 927666001715 homodimer interface [polypeptide binding]; other site 927666001716 motif 1; other site 927666001717 motif 2; other site 927666001718 active site 927666001719 motif 3; other site 927666001720 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 927666001721 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 927666001722 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 927666001723 dimer interface [polypeptide binding]; other site 927666001724 ssDNA binding site [nucleotide binding]; other site 927666001725 tetramer (dimer of dimers) interface [polypeptide binding]; other site 927666001726 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 927666001727 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 927666001728 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 927666001729 Coenzyme A binding pocket [chemical binding]; other site 927666001730 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 927666001731 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 927666001732 active site 927666001733 homodimer interface [polypeptide binding]; other site 927666001734 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 927666001735 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 927666001736 DXD motif; other site 927666001737 Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351 927666001738 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 927666001739 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 927666001740 active site 927666001741 motif I; other site 927666001742 motif II; other site 927666001743 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 927666001744 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 927666001745 active site 927666001746 hypothetical protein; Provisional; Region: PRK07252 927666001747 general stress protein 13; Validated; Region: PRK08059 927666001748 RNA binding site [nucleotide binding]; other site 927666001749 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 927666001750 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 927666001751 S-adenosylmethionine binding site [chemical binding]; other site 927666001752 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 927666001753 GIY-YIG motif/motif A; other site 927666001754 putative active site [active] 927666001755 putative metal binding site [ion binding]; other site 927666001756 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 927666001757 DHH family; Region: DHH; pfam01368 927666001758 DHHA2 domain; Region: DHHA2; pfam02833 927666001759 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 927666001760 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 927666001761 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 927666001762 CsbD-like; Region: CsbD; cl17424 927666001763 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 927666001764 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 927666001765 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 927666001766 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 927666001767 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 927666001768 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 927666001769 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 927666001770 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 927666001771 peptide binding site [polypeptide binding]; other site 927666001772 cystathionine gamma-synthase; Reviewed; Region: PRK07269 927666001773 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 927666001774 homodimer interface [polypeptide binding]; other site 927666001775 substrate-cofactor binding pocket; other site 927666001776 pyridoxal 5'-phosphate binding site [chemical binding]; other site 927666001777 catalytic residue [active] 927666001778 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 927666001779 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 927666001780 pyridoxal 5'-phosphate binding site [chemical binding]; other site 927666001781 homodimer interface [polypeptide binding]; other site 927666001782 catalytic residue [active] 927666001783 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 927666001784 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 927666001785 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 927666001786 ATP binding site [chemical binding]; other site 927666001787 putative Mg++ binding site [ion binding]; other site 927666001788 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 927666001789 nucleotide binding region [chemical binding]; other site 927666001790 ATP-binding site [chemical binding]; other site 927666001791 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 927666001792 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 927666001793 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 927666001794 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 927666001795 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 927666001796 Coenzyme A binding pocket [chemical binding]; other site 927666001797 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 927666001798 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 927666001799 Coenzyme A binding pocket [chemical binding]; other site 927666001800 YceG-like family; Region: YceG; pfam02618 927666001801 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 927666001802 dimerization interface [polypeptide binding]; other site 927666001803 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 927666001804 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 927666001805 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 927666001806 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 927666001807 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 927666001808 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 927666001809 Coenzyme A binding pocket [chemical binding]; other site 927666001810 DNA methylase; Region: N6_N4_Mtase; cl17433 927666001811 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 927666001812 ATP binding site [chemical binding]; other site 927666001813 Mg2+ binding site [ion binding]; other site 927666001814 G-X-G motif; other site 927666001815 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 927666001816 non-specific DNA binding site [nucleotide binding]; other site 927666001817 salt bridge; other site 927666001818 sequence-specific DNA binding site [nucleotide binding]; other site 927666001819 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 927666001820 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 927666001821 active site 927666001822 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 927666001823 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 927666001824 homodimer interface [polypeptide binding]; other site 927666001825 NAD binding pocket [chemical binding]; other site 927666001826 ATP binding pocket [chemical binding]; other site 927666001827 Mg binding site [ion binding]; other site 927666001828 active-site loop [active] 927666001829 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 927666001830 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 927666001831 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 927666001832 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 927666001833 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 927666001834 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 927666001835 catalytic residues [active] 927666001836 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 927666001837 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 927666001838 SelR domain; Region: SelR; pfam01641 927666001839 Response regulator receiver domain; Region: Response_reg; pfam00072 927666001840 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 927666001841 active site 927666001842 phosphorylation site [posttranslational modification] 927666001843 intermolecular recognition site; other site 927666001844 dimerization interface [polypeptide binding]; other site 927666001845 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 927666001846 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 927666001847 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 927666001848 Cache domain; Region: Cache_1; pfam02743 927666001849 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 927666001850 dimerization interface [polypeptide binding]; other site 927666001851 Histidine kinase; Region: His_kinase; pfam06580 927666001852 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 927666001853 ATP binding site [chemical binding]; other site 927666001854 Mg2+ binding site [ion binding]; other site 927666001855 G-X-G motif; other site 927666001856 hypothetical protein; Provisional; Region: PRK13690 927666001857 aminodeoxychorismate synthase; Provisional; Region: PRK07508 927666001858 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 927666001859 substrate-cofactor binding pocket; other site 927666001860 homodimer interface [polypeptide binding]; other site 927666001861 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 927666001862 Aminotransferase class IV; Region: Aminotran_4; pfam01063 927666001863 pyridoxal 5'-phosphate binding site [chemical binding]; other site 927666001864 catalytic residue [active] 927666001865 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 927666001866 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 927666001867 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 927666001868 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 927666001869 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 927666001870 nucleotide binding site [chemical binding]; other site 927666001871 thymidylate synthase; Reviewed; Region: thyA; PRK01827 927666001872 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 927666001873 dimerization interface [polypeptide binding]; other site 927666001874 active site 927666001875 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 927666001876 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 927666001877 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 927666001878 GTPases [General function prediction only]; Region: HflX; COG2262 927666001879 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 927666001880 HflX GTPase family; Region: HflX; cd01878 927666001881 G1 box; other site 927666001882 GTP/Mg2+ binding site [chemical binding]; other site 927666001883 Switch I region; other site 927666001884 G2 box; other site 927666001885 G3 box; other site 927666001886 Switch II region; other site 927666001887 G4 box; other site 927666001888 G5 box; other site 927666001889 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 927666001890 ribonuclease Z; Region: RNase_Z; TIGR02651 927666001891 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 927666001892 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 927666001893 NAD(P) binding site [chemical binding]; other site 927666001894 active site 927666001895 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 927666001896 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 927666001897 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 927666001898 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 927666001899 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 927666001900 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 927666001901 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 927666001902 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 927666001903 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 927666001904 G5 domain; Region: G5; pfam07501 927666001905 G5 domain; Region: G5; pfam07501 927666001906 Cna protein B-type domain; Region: Cna_B; pfam05738 927666001907 Cna protein B-type domain; Region: Cna_B; pfam05738 927666001908 Cna protein B-type domain; Region: Cna_B; pfam05738 927666001909 Cna protein B-type domain; Region: Cna_B; pfam05738 927666001910 Cna protein B-type domain; Region: Cna_B; pfam05738 927666001911 Cna protein B-type domain; Region: Cna_B; pfam05738 927666001912 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 927666001913 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 927666001914 domain interaction interfaces [polypeptide binding]; other site 927666001915 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 927666001916 domain interaction interfaces [polypeptide binding]; other site 927666001917 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 927666001918 domain interaction interfaces [polypeptide binding]; other site 927666001919 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 927666001920 domain interaction interfaces [polypeptide binding]; other site 927666001921 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 927666001922 domain interaction interfaces [polypeptide binding]; other site 927666001923 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 927666001924 S-adenosylmethionine binding site [chemical binding]; other site 927666001925 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 927666001926 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 927666001927 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 927666001928 S-adenosylmethionine binding site [chemical binding]; other site 927666001929 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 927666001930 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 927666001931 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 927666001932 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 927666001933 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 927666001934 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 927666001935 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 927666001936 active site 927666001937 trimer interface [polypeptide binding]; other site 927666001938 allosteric site; other site 927666001939 active site lid [active] 927666001940 hexamer (dimer of trimers) interface [polypeptide binding]; other site 927666001941 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 927666001942 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 927666001943 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 927666001944 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 927666001945 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 927666001946 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 927666001947 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 927666001948 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 927666001949 HPr kinase/phosphorylase; Provisional; Region: PRK05428 927666001950 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 927666001951 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 927666001952 Hpr binding site; other site 927666001953 active site 927666001954 homohexamer subunit interaction site [polypeptide binding]; other site 927666001955 Prolipoprotein diacylglyceryl transferase; Region: LGT; cl00478 927666001956 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 927666001957 YtxH-like protein; Region: YtxH; pfam12732 927666001958 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 927666001959 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 927666001960 FeS/SAM binding site; other site 927666001961 HemN C-terminal domain; Region: HemN_C; pfam06969 927666001962 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 927666001963 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 927666001964 active site 927666001965 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 927666001966 active site 927666001967 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 927666001968 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 927666001969 active site 927666001970 motif I; other site 927666001971 motif II; other site 927666001972 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 927666001973 Predicted membrane protein [Function unknown]; Region: COG4478 927666001974 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 927666001975 ArsC family; Region: ArsC; pfam03960 927666001976 putative catalytic residues [active] 927666001977 thiol/disulfide switch; other site 927666001978 hypothetical protein; Provisional; Region: PRK04387 927666001979 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 927666001980 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 927666001981 active site 927666001982 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 927666001983 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 927666001984 S-adenosylmethionine binding site [chemical binding]; other site 927666001985 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 927666001986 phosphate binding protein; Region: ptsS_2; TIGR02136 927666001987 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 927666001988 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 927666001989 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 927666001990 dimer interface [polypeptide binding]; other site 927666001991 conserved gate region; other site 927666001992 putative PBP binding loops; other site 927666001993 ABC-ATPase subunit interface; other site 927666001994 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 927666001995 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 927666001996 dimer interface [polypeptide binding]; other site 927666001997 conserved gate region; other site 927666001998 putative PBP binding loops; other site 927666001999 ABC-ATPase subunit interface; other site 927666002000 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 927666002001 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 927666002002 Walker A/P-loop; other site 927666002003 ATP binding site [chemical binding]; other site 927666002004 Q-loop/lid; other site 927666002005 ABC transporter signature motif; other site 927666002006 Walker B; other site 927666002007 D-loop; other site 927666002008 H-loop/switch region; other site 927666002009 phosphate transporter ATP-binding protein; Provisional; Region: PRK14239 927666002010 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 927666002011 Walker A/P-loop; other site 927666002012 ATP binding site [chemical binding]; other site 927666002013 Q-loop/lid; other site 927666002014 ABC transporter signature motif; other site 927666002015 Walker B; other site 927666002016 D-loop; other site 927666002017 H-loop/switch region; other site 927666002018 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 927666002019 PhoU domain; Region: PhoU; pfam01895 927666002020 PhoU domain; Region: PhoU; pfam01895 927666002021 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 927666002022 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 927666002023 substrate binding pocket [chemical binding]; other site 927666002024 membrane-bound complex binding site; other site 927666002025 hinge residues; other site 927666002026 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 927666002027 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 927666002028 DNA-binding site [nucleotide binding]; DNA binding site 927666002029 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 927666002030 pyridoxal 5'-phosphate binding site [chemical binding]; other site 927666002031 homodimer interface [polypeptide binding]; other site 927666002032 catalytic residue [active] 927666002033 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 927666002034 Putative membrane peptidase family (DUF2324); Region: DUF2324; cl01810 927666002035 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 927666002036 FAD binding domain; Region: FAD_binding_4; pfam01565 927666002037 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 927666002038 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 927666002039 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 927666002040 Walker A/P-loop; other site 927666002041 ATP binding site [chemical binding]; other site 927666002042 Q-loop/lid; other site 927666002043 ABC transporter signature motif; other site 927666002044 Walker B; other site 927666002045 D-loop; other site 927666002046 H-loop/switch region; other site 927666002047 TOBE domain; Region: TOBE_2; pfam08402 927666002048 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 927666002049 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 927666002050 dimer interface [polypeptide binding]; other site 927666002051 conserved gate region; other site 927666002052 putative PBP binding loops; other site 927666002053 ABC-ATPase subunit interface; other site 927666002054 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 927666002055 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 927666002056 dimer interface [polypeptide binding]; other site 927666002057 conserved gate region; other site 927666002058 putative PBP binding loops; other site 927666002059 ABC-ATPase subunit interface; other site 927666002060 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 927666002061 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 927666002062 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 927666002063 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 927666002064 catalytic site [active] 927666002065 metal binding site [ion binding]; metal-binding site 927666002066 PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768 927666002067 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 927666002068 Tubby C 2; Region: Tub_2; cl02043 927666002069 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 927666002070 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 927666002071 motif 1; other site 927666002072 active site 927666002073 motif 2; other site 927666002074 motif 3; other site 927666002075 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 927666002076 DHHA1 domain; Region: DHHA1; pfam02272 927666002077 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 927666002078 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 927666002079 active site 927666002080 Na/Ca binding site [ion binding]; other site 927666002081 catalytic site [active] 927666002082 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 927666002083 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 927666002084 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 927666002085 putative RNA binding site [nucleotide binding]; other site 927666002086 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 927666002087 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 927666002088 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 927666002089 active site 927666002090 catalytic residue [active] 927666002091 dimer interface [polypeptide binding]; other site 927666002092 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 927666002093 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 927666002094 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 927666002095 shikimate binding site; other site 927666002096 NAD(P) binding site [chemical binding]; other site 927666002097 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 927666002098 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 927666002099 active site 927666002100 dimer interface [polypeptide binding]; other site 927666002101 metal binding site [ion binding]; metal-binding site 927666002102 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 927666002103 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 927666002104 Tetramer interface [polypeptide binding]; other site 927666002105 active site 927666002106 FMN-binding site [chemical binding]; other site 927666002107 prephenate dehydrogenase; Validated; Region: PRK06545 927666002108 prephenate dehydrogenase; Validated; Region: PRK08507 927666002109 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 927666002110 hypothetical protein; Provisional; Region: PRK13676 927666002111 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 927666002112 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 927666002113 hinge; other site 927666002114 active site 927666002115 shikimate kinase; Reviewed; Region: aroK; PRK00131 927666002116 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 927666002117 ADP binding site [chemical binding]; other site 927666002118 magnesium binding site [ion binding]; other site 927666002119 putative shikimate binding site; other site 927666002120 prephenate dehydratase; Provisional; Region: PRK11898 927666002121 Prephenate dehydratase; Region: PDT; pfam00800 927666002122 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 927666002123 putative L-Phe binding site [chemical binding]; other site 927666002124 Transcriptional regulator [Transcription]; Region: LytR; COG1316 927666002125 LPS biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3475 927666002126 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 927666002127 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 927666002128 active site 927666002129 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 927666002130 O-Antigen ligase; Region: Wzy_C; pfam04932 927666002131 LicD family; Region: LicD; cl01378 927666002132 LicD family; Region: LicD; pfam04991 927666002133 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 927666002134 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 927666002135 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 927666002136 adaptor protein; Provisional; Region: PRK02315 927666002137 homoserine dehydrogenase; Provisional; Region: PRK06349 927666002138 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 927666002139 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 927666002140 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 927666002141 homoserine kinase; Provisional; Region: PRK01212 927666002142 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 927666002143 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 927666002144 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 927666002145 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 927666002146 SelR domain; Region: SelR; pfam01641 927666002147 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 927666002148 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 927666002149 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 927666002150 Walker A/P-loop; other site 927666002151 ATP binding site [chemical binding]; other site 927666002152 Q-loop/lid; other site 927666002153 ABC transporter signature motif; other site 927666002154 Walker B; other site 927666002155 D-loop; other site 927666002156 H-loop/switch region; other site 927666002157 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 927666002158 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 927666002159 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 927666002160 Walker A/P-loop; other site 927666002161 ATP binding site [chemical binding]; other site 927666002162 Q-loop/lid; other site 927666002163 ABC transporter signature motif; other site 927666002164 Walker B; other site 927666002165 D-loop; other site 927666002166 H-loop/switch region; other site 927666002167 chlorohydrolase; Validated; Region: PRK06687 927666002168 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 927666002169 active site 927666002170 putative substrate binding pocket [chemical binding]; other site 927666002171 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 927666002172 23S rRNA interface [nucleotide binding]; other site 927666002173 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 927666002174 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 927666002175 core dimer interface [polypeptide binding]; other site 927666002176 L10 interface [polypeptide binding]; other site 927666002177 L11 interface [polypeptide binding]; other site 927666002178 putative EF-Tu interaction site [polypeptide binding]; other site 927666002179 putative EF-G interaction site [polypeptide binding]; other site 927666002180 Predicted Zn-dependent protease (DUF2268); Region: DUF2268; pfam10026 927666002181 EXLDI protein; Region: EXLDI; TIGR04342 927666002182 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 927666002183 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 927666002184 Coenzyme A binding pocket [chemical binding]; other site 927666002185 glutamate dehydrogenase; Provisional; Region: PRK09414 927666002186 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 927666002187 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 927666002188 NAD(P) binding site [chemical binding]; other site 927666002189 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 927666002190 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 927666002191 active site 927666002192 FMN binding site [chemical binding]; other site 927666002193 substrate binding site [chemical binding]; other site 927666002194 catalytic residues [active] 927666002195 homodimer interface [polypeptide binding]; other site 927666002196 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 927666002197 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 927666002198 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 927666002199 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 927666002200 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 927666002201 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 927666002202 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 927666002203 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 927666002204 FeS/SAM binding site; other site 927666002205 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 927666002206 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 927666002207 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 927666002208 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 927666002209 ABC transporter; Region: ABC_tran_2; pfam12848 927666002210 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 927666002211 Uncharacterized Zn-finger containing protein [General function prediction only]; Region: COG1645 927666002212 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 927666002213 active site 927666002214 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 927666002215 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 927666002216 KH domain; Region: KH_4; pfam13083 927666002217 G-X-X-G motif; other site 927666002218 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 927666002219 metal binding site [ion binding]; metal-binding site 927666002220 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 927666002221 EamA-like transporter family; Region: EamA; pfam00892 927666002222 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 927666002223 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 927666002224 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 927666002225 RimM N-terminal domain; Region: RimM; pfam01782 927666002226 PRC-barrel domain; Region: PRC; pfam05239 927666002227 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 927666002228 ATP cone domain; Region: ATP-cone; pfam03477 927666002229 C-terminal domain of eIF4-gamma/eIF5/eIF2b-epsilon; Region: W2; cl17013 927666002230 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 927666002231 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 927666002232 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 927666002233 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 927666002234 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 927666002235 glutathione reductase; Validated; Region: PRK06116 927666002236 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 927666002237 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 927666002238 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 927666002239 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 927666002240 HlyD family secretion protein; Region: HlyD_3; pfam13437 927666002241 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 927666002242 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 927666002243 Walker A/P-loop; other site 927666002244 ATP binding site [chemical binding]; other site 927666002245 Q-loop/lid; other site 927666002246 ABC transporter signature motif; other site 927666002247 Walker B; other site 927666002248 D-loop; other site 927666002249 H-loop/switch region; other site 927666002250 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 927666002251 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 927666002252 FtsX-like permease family; Region: FtsX; pfam02687 927666002253 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 927666002254 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 927666002255 active site 927666002256 HIGH motif; other site 927666002257 KMSKS motif; other site 927666002258 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 927666002259 tRNA binding surface [nucleotide binding]; other site 927666002260 anticodon binding site; other site 927666002261 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 927666002262 dimer interface [polypeptide binding]; other site 927666002263 putative tRNA-binding site [nucleotide binding]; other site 927666002264 topology modulation protein; Provisional; Region: PRK07261 927666002265 AAA domain; Region: AAA_17; pfam13207 927666002266 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 927666002267 pantothenate kinase; Provisional; Region: PRK05439 927666002268 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 927666002269 ATP-binding site [chemical binding]; other site 927666002270 CoA-binding site [chemical binding]; other site 927666002271 Mg2+-binding site [ion binding]; other site 927666002272 Methyltransferase domain; Region: Methyltransf_31; pfam13847 927666002273 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 927666002274 S-adenosylmethionine binding site [chemical binding]; other site 927666002275 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 927666002276 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 927666002277 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 927666002278 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 927666002279 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 927666002280 intersubunit interface [polypeptide binding]; other site 927666002281 active site 927666002282 catalytic residue [active] 927666002283 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 927666002284 active site 927666002285 catalytic motif [active] 927666002286 Zn binding site [ion binding]; other site 927666002287 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 927666002288 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 927666002289 ligand binding site [chemical binding]; other site 927666002290 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 927666002291 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 927666002292 Walker A/P-loop; other site 927666002293 ATP binding site [chemical binding]; other site 927666002294 Q-loop/lid; other site 927666002295 ABC transporter signature motif; other site 927666002296 Walker B; other site 927666002297 D-loop; other site 927666002298 H-loop/switch region; other site 927666002299 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 927666002300 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 927666002301 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 927666002302 TM-ABC transporter signature motif; other site 927666002303 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 927666002304 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 927666002305 TM-ABC transporter signature motif; other site 927666002306 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 927666002307 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 927666002308 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 927666002309 Mg2+ binding site [ion binding]; other site 927666002310 G-X-G motif; other site 927666002311 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 927666002312 anchoring element; other site 927666002313 dimer interface [polypeptide binding]; other site 927666002314 ATP binding site [chemical binding]; other site 927666002315 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 927666002316 active site 927666002317 putative metal-binding site [ion binding]; other site 927666002318 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 927666002319 Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439 927666002320 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 927666002321 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 927666002322 CAP-like domain; other site 927666002323 active site 927666002324 primary dimer interface [polypeptide binding]; other site 927666002325 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 927666002326 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 927666002327 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 927666002328 homodimer interface [polypeptide binding]; other site 927666002329 substrate-cofactor binding pocket; other site 927666002330 catalytic residue [active] 927666002331 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 927666002332 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 927666002333 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 927666002334 RNA binding site [nucleotide binding]; other site 927666002335 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 927666002336 RNA binding site [nucleotide binding]; other site 927666002337 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 927666002338 RNA binding site [nucleotide binding]; other site 927666002339 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 927666002340 RNA binding site [nucleotide binding]; other site 927666002341 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 927666002342 GAF domain; Region: GAF_2; pfam13185 927666002343 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 927666002344 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 927666002345 Walker A motif; other site 927666002346 ATP binding site [chemical binding]; other site 927666002347 Walker B motif; other site 927666002348 arginine finger; other site 927666002349 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 927666002350 Protein of unknown function (DUF3272); Region: DUF3272; pfam11676 927666002351 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 927666002352 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 927666002353 Walker A/P-loop; other site 927666002354 ATP binding site [chemical binding]; other site 927666002355 Q-loop/lid; other site 927666002356 ABC transporter signature motif; other site 927666002357 Walker B; other site 927666002358 D-loop; other site 927666002359 H-loop/switch region; other site 927666002360 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 927666002361 FeS assembly protein SufD; Region: sufD; TIGR01981 927666002362 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 927666002363 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 927666002364 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 927666002365 catalytic residue [active] 927666002366 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 927666002367 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 927666002368 trimerization site [polypeptide binding]; other site 927666002369 active site 927666002370 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 927666002371 FeS assembly protein SufB; Region: sufB; TIGR01980 927666002372 amino acid transporter; Region: 2A0306; TIGR00909 927666002373 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 927666002374 Uncharacterized conserved protein [Function unknown]; Region: COG1284 927666002375 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 927666002376 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 927666002377 EDD domain protein, DegV family; Region: DegV; TIGR00762 927666002378 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 927666002379 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 927666002380 IHF dimer interface [polypeptide binding]; other site 927666002381 IHF - DNA interface [nucleotide binding]; other site 927666002382 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 927666002383 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 927666002384 tetramer (dimer of dimers) interface [polypeptide binding]; other site 927666002385 NAD binding site [chemical binding]; other site 927666002386 dimer interface [polypeptide binding]; other site 927666002387 substrate binding site [chemical binding]; other site 927666002388 DNA gyrase subunit A; Validated; Region: PRK05560 927666002389 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 927666002390 CAP-like domain; other site 927666002391 active site 927666002392 primary dimer interface [polypeptide binding]; other site 927666002393 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 927666002394 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 927666002395 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 927666002396 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 927666002397 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 927666002398 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 927666002399 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 927666002400 active site 927666002401 catalytic site [active] 927666002402 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 927666002403 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 927666002404 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 927666002405 homodimer interface [polypeptide binding]; other site 927666002406 substrate-cofactor binding pocket; other site 927666002407 pyridoxal 5'-phosphate binding site [chemical binding]; other site 927666002408 catalytic residue [active] 927666002409 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 927666002410 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 927666002411 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 927666002412 Domain of unknown function (DUF368); Region: DUF368; cl00893 927666002413 stage V sporulation protein K; Region: spore_V_K; TIGR02881 927666002414 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 927666002415 Walker A motif; other site 927666002416 ATP binding site [chemical binding]; other site 927666002417 Walker B motif; other site 927666002418 arginine finger; other site 927666002419 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 927666002420 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 927666002421 RNA binding site [nucleotide binding]; other site 927666002422 active site 927666002423 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 927666002424 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 927666002425 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 927666002426 Sugar specificity; other site 927666002427 Pyrimidine base specificity; other site 927666002428 ATP-binding site [chemical binding]; other site 927666002429 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 927666002430 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 927666002431 generic binding surface II; other site 927666002432 generic binding surface I; other site 927666002433 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 927666002434 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 927666002435 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 927666002436 substrate binding pocket [chemical binding]; other site 927666002437 chain length determination region; other site 927666002438 substrate-Mg2+ binding site; other site 927666002439 catalytic residues [active] 927666002440 aspartate-rich region 1; other site 927666002441 active site lid residues [active] 927666002442 aspartate-rich region 2; other site 927666002443 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 927666002444 S4 RNA-binding domain; Region: S4; smart00363 927666002445 RNA binding surface [nucleotide binding]; other site 927666002446 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 927666002447 Arginine repressor [Transcription]; Region: ArgR; COG1438 927666002448 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 927666002449 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 927666002450 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 927666002451 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 927666002452 Walker A/P-loop; other site 927666002453 ATP binding site [chemical binding]; other site 927666002454 Q-loop/lid; other site 927666002455 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 927666002456 Q-loop/lid; other site 927666002457 ABC transporter signature motif; other site 927666002458 Walker B; other site 927666002459 D-loop; other site 927666002460 H-loop/switch region; other site 927666002461 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 927666002462 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 927666002463 active site 927666002464 metal binding site [ion binding]; metal-binding site 927666002465 GTP-binding protein LepA; Provisional; Region: PRK05433 927666002466 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 927666002467 G1 box; other site 927666002468 putative GEF interaction site [polypeptide binding]; other site 927666002469 GTP/Mg2+ binding site [chemical binding]; other site 927666002470 Switch I region; other site 927666002471 G2 box; other site 927666002472 G3 box; other site 927666002473 Switch II region; other site 927666002474 G4 box; other site 927666002475 G5 box; other site 927666002476 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 927666002477 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 927666002478 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 927666002479 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 927666002480 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 927666002481 DNA protecting protein DprA; Region: dprA; TIGR00732 927666002482 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 927666002483 DNA topoisomerase I, bacterial; Region: topA_bact; TIGR01051 927666002484 active site 927666002485 interdomain interaction site; other site 927666002486 putative metal-binding site [ion binding]; other site 927666002487 nucleotide binding site [chemical binding]; other site 927666002488 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 927666002489 domain I; other site 927666002490 DNA binding groove [nucleotide binding] 927666002491 phosphate binding site [ion binding]; other site 927666002492 domain II; other site 927666002493 domain III; other site 927666002494 nucleotide binding site [chemical binding]; other site 927666002495 catalytic site [active] 927666002496 domain IV; other site 927666002497 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 927666002498 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 927666002499 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 927666002500 2-isopropylmalate synthase; Validated; Region: PRK00915 927666002501 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 927666002502 active site 927666002503 catalytic residues [active] 927666002504 metal binding site [ion binding]; metal-binding site 927666002505 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 927666002506 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 927666002507 tartrate dehydrogenase; Region: TTC; TIGR02089 927666002508 Predicted membrane protein [Function unknown]; Region: COG3326 927666002509 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 927666002510 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 927666002511 substrate binding site [chemical binding]; other site 927666002512 ligand binding site [chemical binding]; other site 927666002513 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 927666002514 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 927666002515 substrate binding site [chemical binding]; other site 927666002516 Telomere recombination; Region: Sua5_yciO_yrdC; cl00305 927666002517 GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401 927666002518 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 927666002519 Walker A motif; other site 927666002520 ATP binding site [chemical binding]; other site 927666002521 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 927666002522 McrBC 5-methylcytosine restriction system component [Defense mechanisms]; Region: McrC; COG4268 927666002523 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 927666002524 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 927666002525 active site 927666002526 ribonuclease III; Reviewed; Region: rnc; PRK00102 927666002527 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 927666002528 dimerization interface [polypeptide binding]; other site 927666002529 active site 927666002530 metal binding site [ion binding]; metal-binding site 927666002531 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 927666002532 dsRNA binding site [nucleotide binding]; other site 927666002533 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 927666002534 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 927666002535 Walker A/P-loop; other site 927666002536 ATP binding site [chemical binding]; other site 927666002537 Q-loop/lid; other site 927666002538 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 927666002539 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 927666002540 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 927666002541 ABC transporter signature motif; other site 927666002542 Walker B; other site 927666002543 D-loop; other site 927666002544 H-loop/switch region; other site 927666002545 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 927666002546 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 927666002547 active site 927666002548 Riboflavin kinase; Region: Flavokinase; smart00904 927666002549 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 927666002550 HsdM N-terminal domain; Region: HsdM_N; pfam12161 927666002551 Methyltransferase domain; Region: Methyltransf_26; pfam13659 927666002552 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 927666002553 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 927666002554 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 927666002555 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 927666002556 prophage relict 927666002557 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 927666002558 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 927666002559 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 927666002560 active site 927666002561 DNA binding site [nucleotide binding] 927666002562 Int/Topo IB signature motif; other site 927666002563 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 927666002564 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 927666002565 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 927666002566 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 927666002567 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 927666002568 ATP binding site [chemical binding]; other site 927666002569 putative Mg++ binding site [ion binding]; other site 927666002570 nucleotide binding region [chemical binding]; other site 927666002571 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 927666002572 ATP-binding site [chemical binding]; other site 927666002573 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 927666002574 Tetratricopeptide repeat; Region: TPR_12; pfam13424 927666002575 Predicted membrane protein [Function unknown]; Region: COG3689 927666002576 Predicted permeases [General function prediction only]; Region: COG0701 927666002577 Type III restriction/modification enzyme methylation subunit; Region: TypeIII_RM_meth; pfam12564 927666002578 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 927666002579 DNA methylase; Region: N6_N4_Mtase; pfam01555 927666002580 DNA methylase; Region: N6_N4_Mtase; pfam01555 927666002581 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3421 927666002582 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 927666002583 ATP binding site [chemical binding]; other site 927666002584 putative Mg++ binding site [ion binding]; other site 927666002585 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 927666002586 Walker A/P-loop; other site 927666002587 ATP binding site [chemical binding]; other site 927666002588 Q-loop/lid; other site 927666002589 AAA domain; Region: AAA_21; pfam13304 927666002590 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 927666002591 Walker B; other site 927666002592 D-loop; other site 927666002593 H-loop/switch region; other site 927666002594 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 927666002595 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 927666002596 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 927666002597 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 927666002598 RNA binding site [nucleotide binding]; other site 927666002599 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 927666002600 hypothetical protein; Provisional; Region: PRK04351 927666002601 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 927666002602 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 927666002603 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 927666002604 Walker A/P-loop; other site 927666002605 ATP binding site [chemical binding]; other site 927666002606 Q-loop/lid; other site 927666002607 ABC transporter signature motif; other site 927666002608 Walker B; other site 927666002609 D-loop; other site 927666002610 H-loop/switch region; other site 927666002611 FtsX-like permease family; Region: FtsX; pfam02687 927666002612 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 927666002613 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 927666002614 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 927666002615 active site 927666002616 motif I; other site 927666002617 motif II; other site 927666002618 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 927666002619 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 927666002620 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 927666002621 motif II; other site 927666002622 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 927666002623 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 927666002624 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 927666002625 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 927666002626 P loop; other site 927666002627 GTP binding site [chemical binding]; other site 927666002628 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 927666002629 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 927666002630 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 927666002631 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 927666002632 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 927666002633 Walker A/P-loop; other site 927666002634 ATP binding site [chemical binding]; other site 927666002635 Q-loop/lid; other site 927666002636 ABC transporter signature motif; other site 927666002637 Walker B; other site 927666002638 D-loop; other site 927666002639 H-loop/switch region; other site 927666002640 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 927666002641 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 927666002642 substrate binding pocket [chemical binding]; other site 927666002643 membrane-bound complex binding site; other site 927666002644 hinge residues; other site 927666002645 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 927666002646 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 927666002647 substrate binding pocket [chemical binding]; other site 927666002648 membrane-bound complex binding site; other site 927666002649 hinge residues; other site 927666002650 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 927666002651 dimer interface [polypeptide binding]; other site 927666002652 conserved gate region; other site 927666002653 putative PBP binding loops; other site 927666002654 ABC-ATPase subunit interface; other site 927666002655 excinuclease ABC subunit B; Provisional; Region: PRK05298 927666002656 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 927666002657 ATP binding site [chemical binding]; other site 927666002658 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 927666002659 nucleotide binding region [chemical binding]; other site 927666002660 ATP-binding site [chemical binding]; other site 927666002661 Ultra-violet resistance protein B; Region: UvrB; pfam12344 927666002662 UvrB/uvrC motif; Region: UVR; pfam02151 927666002663 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 927666002664 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 927666002665 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 927666002666 Coenzyme A binding pocket [chemical binding]; other site 927666002667 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 927666002668 putative active site [active] 927666002669 nucleotide binding site [chemical binding]; other site 927666002670 nudix motif; other site 927666002671 putative metal binding site [ion binding]; other site 927666002672 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 927666002673 HTH domain; Region: HTH_11; pfam08279 927666002674 3H domain; Region: 3H; pfam02829 927666002675 Predicted membrane protein [Function unknown]; Region: COG4684 927666002676 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313 927666002677 Flavoprotein; Region: Flavoprotein; pfam02441 927666002678 phosphopantothenate--cysteine ligase; Validated; Region: PRK06732 927666002679 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 927666002680 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 927666002681 Potassium binding sites [ion binding]; other site 927666002682 Cesium cation binding sites [ion binding]; other site 927666002683 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 927666002684 Part of AAA domain; Region: AAA_19; pfam13245 927666002685 Family description; Region: UvrD_C_2; pfam13538 927666002686 hypothetical protein; Reviewed; Region: PRK00024 927666002687 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 927666002688 MPN+ (JAMM) motif; other site 927666002689 Zinc-binding site [ion binding]; other site 927666002690 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 927666002691 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 927666002692 catalytic triad [active] 927666002693 AT-rich DNA-binding protein [General function prediction only]; Region: COG2344 927666002694 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 927666002695 CoA binding domain; Region: CoA_binding; pfam02629 927666002696 Putative amino acid metabolism; Region: DUF1831; pfam08866 927666002697 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 927666002698 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 927666002699 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 927666002700 catalytic residue [active] 927666002701 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458 927666002702 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 927666002703 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 927666002704 active site 927666002705 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 927666002706 putative active site [active] 927666002707 putative triphosphate binding site [ion binding]; other site 927666002708 putative metal binding residues [ion binding]; other site 927666002709 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 927666002710 synthetase active site [active] 927666002711 NTP binding site [chemical binding]; other site 927666002712 metal binding site [ion binding]; metal-binding site 927666002713 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 927666002714 ATP-NAD kinase; Region: NAD_kinase; pfam01513 927666002715 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 927666002716 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 927666002717 RNA binding surface [nucleotide binding]; other site 927666002718 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 927666002719 active site 927666002720 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 927666002721 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 927666002722 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 927666002723 minor groove reading motif; other site 927666002724 helix-hairpin-helix signature motif; other site 927666002725 substrate binding pocket [chemical binding]; other site 927666002726 active site 927666002727 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 927666002728 DNA binding and oxoG recognition site [nucleotide binding] 927666002729 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 927666002730 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 927666002731 active site 927666002732 phosphorylation site [posttranslational modification] 927666002733 intermolecular recognition site; other site 927666002734 dimerization interface [polypeptide binding]; other site 927666002735 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 927666002736 DNA binding site [nucleotide binding] 927666002737 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 927666002738 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 927666002739 putative active site [active] 927666002740 heme pocket [chemical binding]; other site 927666002741 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 927666002742 dimer interface [polypeptide binding]; other site 927666002743 phosphorylation site [posttranslational modification] 927666002744 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 927666002745 ATP binding site [chemical binding]; other site 927666002746 Mg2+ binding site [ion binding]; other site 927666002747 G-X-G motif; other site 927666002748 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 927666002749 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 927666002750 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 927666002751 catalytic residues [active] 927666002752 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 927666002753 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 927666002754 active site 927666002755 substrate binding site [chemical binding]; other site 927666002756 metal binding site [ion binding]; metal-binding site 927666002757 Domain of unknown function (DUF4352); Region: DUF4352; pfam11611 927666002758 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 927666002759 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 927666002760 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 927666002761 ABC transporter; Region: ABC_tran_2; pfam12848 927666002762 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 927666002763 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 927666002764 non-specific DNA binding site [nucleotide binding]; other site 927666002765 salt bridge; other site 927666002766 sequence-specific DNA binding site [nucleotide binding]; other site 927666002767 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 927666002768 H+ Antiporter protein; Region: 2A0121; TIGR00900 927666002769 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 927666002770 putative substrate translocation pore; other site 927666002771 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 927666002772 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 927666002773 nucleotide binding pocket [chemical binding]; other site 927666002774 K-X-D-G motif; other site 927666002775 catalytic site [active] 927666002776 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 927666002777 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 927666002778 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 927666002779 Dimer interface [polypeptide binding]; other site 927666002780 BRCT sequence motif; other site 927666002781 pullulanase, type I; Region: pulA_typeI; TIGR02104 927666002782 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 927666002783 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 927666002784 Ca binding site [ion binding]; other site 927666002785 active site 927666002786 catalytic site [active] 927666002787 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 927666002788 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 927666002789 tetrameric interface [polypeptide binding]; other site 927666002790 activator binding site; other site 927666002791 NADP binding site [chemical binding]; other site 927666002792 substrate binding site [chemical binding]; other site 927666002793 catalytic residues [active] 927666002794 glycogen branching enzyme; Provisional; Region: PRK12313 927666002795 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 927666002796 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 927666002797 active site 927666002798 catalytic site [active] 927666002799 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 927666002800 glucose-1-phosphate adenylyltransferase; Region: glgC; TIGR02091 927666002801 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 927666002802 ligand binding site; other site 927666002803 oligomer interface; other site 927666002804 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 927666002805 dimer interface [polypeptide binding]; other site 927666002806 N-terminal domain interface [polypeptide binding]; other site 927666002807 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 927666002808 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 927666002809 active site 927666002810 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 927666002811 dimer interface [polypeptide binding]; other site 927666002812 N-terminal domain interface [polypeptide binding]; other site 927666002813 sulfate 1 binding site; other site 927666002814 glycogen synthase; Provisional; Region: glgA; PRK00654 927666002815 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 927666002816 ADP-binding pocket [chemical binding]; other site 927666002817 homodimer interface [polypeptide binding]; other site 927666002818 phosphoserine phosphatase SerB; Region: serB; TIGR00338 927666002819 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 927666002820 motif II; other site 927666002821 glycerate kinase; Region: TIGR00045 927666002822 Protein of unknown function (DUF1694); Region: DUF1694; cl02318 927666002823 enolase; Provisional; Region: eno; PRK00077 927666002824 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 927666002825 dimer interface [polypeptide binding]; other site 927666002826 metal binding site [ion binding]; metal-binding site 927666002827 substrate binding pocket [chemical binding]; other site 927666002828 Flagellin N-methylase; Region: FliB; pfam03692 927666002829 Helix-turn-helix domain; Region: HTH_18; pfam12833 927666002830 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 927666002831 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 927666002832 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 927666002833 Ligand binding site; other site 927666002834 Putative Catalytic site; other site 927666002835 DXD motif; other site 927666002836 Predicted membrane protein [Function unknown]; Region: COG2246 927666002837 GtrA-like protein; Region: GtrA; pfam04138 927666002838 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 927666002839 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 927666002840 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 927666002841 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 927666002842 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392 927666002843 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 927666002844 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 927666002845 AlwI restriction endonuclease; Region: RE_AlwI; pfam09491 927666002846 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 927666002847 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 927666002848 active site 927666002849 motif I; other site 927666002850 motif II; other site 927666002851 Domain of unknown function (DUF4336); Region: DUF4336; pfam14234 927666002852 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 927666002853 ligand binding site [chemical binding]; other site 927666002854 active site 927666002855 UGI interface [polypeptide binding]; other site 927666002856 catalytic site [active] 927666002857 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 927666002858 putative active site [active] 927666002859 nucleotide binding site [chemical binding]; other site 927666002860 nudix motif; other site 927666002861 putative metal binding site [ion binding]; other site 927666002862 dihydroorotase; Validated; Region: pyrC; PRK09357 927666002863 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 927666002864 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 927666002865 active site 927666002866 multidrug efflux protein; Reviewed; Region: PRK01766 927666002867 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 927666002868 cation binding site [ion binding]; other site 927666002869 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 927666002870 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 927666002871 tetramer interface [polypeptide binding]; other site 927666002872 TPP-binding site [chemical binding]; other site 927666002873 heterodimer interface [polypeptide binding]; other site 927666002874 phosphorylation loop region [posttranslational modification] 927666002875 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 927666002876 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 927666002877 alpha subunit interface [polypeptide binding]; other site 927666002878 TPP binding site [chemical binding]; other site 927666002879 heterodimer interface [polypeptide binding]; other site 927666002880 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 927666002881 dihydrolipoamide acetyltransferase; Provisional; Region: PRK14843 927666002882 e3 binding domain; Region: E3_binding; pfam02817 927666002883 e3 binding domain; Region: E3_binding; pfam02817 927666002884 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 927666002885 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 927666002886 E3 interaction surface; other site 927666002887 lipoyl attachment site [posttranslational modification]; other site 927666002888 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 927666002889 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 927666002890 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 927666002891 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 927666002892 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 927666002893 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 927666002894 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 927666002895 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 927666002896 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 927666002897 active site 927666002898 DNA binding site [nucleotide binding] 927666002899 Int/Topo IB signature motif; other site 927666002900 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 927666002901 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 927666002902 Cl- selectivity filter; other site 927666002903 Cl- binding residues [ion binding]; other site 927666002904 pore gating glutamate residue; other site 927666002905 dimer interface [polypeptide binding]; other site 927666002906 H+/Cl- coupling transport residue; other site 927666002907 TrkA-C domain; Region: TrkA_C; pfam02080 927666002908 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 927666002909 RNA/DNA hybrid binding site [nucleotide binding]; other site 927666002910 active site 927666002911 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 927666002912 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 927666002913 GTP/Mg2+ binding site [chemical binding]; other site 927666002914 G4 box; other site 927666002915 G5 box; other site 927666002916 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 927666002917 G1 box; other site 927666002918 G1 box; other site 927666002919 GTP/Mg2+ binding site [chemical binding]; other site 927666002920 Switch I region; other site 927666002921 G2 box; other site 927666002922 G2 box; other site 927666002923 Switch I region; other site 927666002924 G3 box; other site 927666002925 G3 box; other site 927666002926 Switch II region; other site 927666002927 Switch II region; other site 927666002928 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 927666002929 PemK-like protein; Region: PemK; pfam02452 927666002930 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 927666002931 Part of AAA domain; Region: AAA_19; pfam13245 927666002932 Family description; Region: UvrD_C_2; pfam13538 927666002933 Family description; Region: UvrD_C_2; pfam13538 927666002934 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 927666002935 ATP-dependent nuclease subunit B; Region: rexB_recomb; TIGR02774 927666002936 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 927666002937 hypothetical protein; Provisional; Region: PRK02268 927666002938 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 927666002939 MarR family; Region: MarR_2; pfam12802 927666002940 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 927666002941 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 927666002942 active site 927666002943 motif I; other site 927666002944 motif II; other site 927666002945 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 927666002946 motif II; other site 927666002947 TraX protein; Region: TraX; cl05434 927666002948 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 927666002949 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 927666002950 putative active site; other site 927666002951 catalytic triad [active] 927666002952 putative dimer interface [polypeptide binding]; other site 927666002953 agmatine deiminase; Provisional; Region: PRK13551 927666002954 agmatine deiminase; Region: agmatine_aguA; TIGR03380 927666002955 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 927666002956 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 927666002957 dimer interface [polypeptide binding]; other site 927666002958 active site 927666002959 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 927666002960 catalytic residues [active] 927666002961 substrate binding site [chemical binding]; other site 927666002962 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 927666002963 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; pfam01488 927666002964 spermidine synthase; Provisional; Region: PRK00811 927666002965 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 927666002966 S-adenosylmethionine binding site [chemical binding]; other site 927666002967 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 927666002968 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 927666002969 homodimer interface [polypeptide binding]; other site 927666002970 pyridoxal 5'-phosphate binding site [chemical binding]; other site 927666002971 catalytic residue [active] 927666002972 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 927666002973 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 927666002974 Domain of unknown function (DUF4300); Region: DUF4300; pfam14133 927666002975 maltodextrin glucosidase; Provisional; Region: PRK10785 927666002976 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 927666002977 homodimer interface [polypeptide binding]; other site 927666002978 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 927666002979 active site 927666002980 homodimer interface [polypeptide binding]; other site 927666002981 catalytic site [active] 927666002982 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 927666002983 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 927666002984 Protein of unknown function (DUF443); Region: DUF443; cl04467 927666002985 tandem five-transmembrane protein; Region: Gpos_tandem_5TM; TIGR01218 927666002986 tandem five-transmembrane protein; Region: Gpos_tandem_5TM; TIGR01218 927666002987 tandem five-transmembrane protein; Region: Gpos_tandem_5TM; TIGR01218 927666002988 tandem five-transmembrane protein; Region: Gpos_tandem_5TM; TIGR01218 927666002989 tandem five-transmembrane protein; Region: Gpos_tandem_5TM; TIGR01218 927666002990 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 927666002991 CAAX protease self-immunity; Region: Abi; pfam02517 927666002992 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 927666002993 conserved cys residue [active] 927666002994 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 927666002995 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 927666002996 TRAM domain; Region: TRAM; cl01282 927666002997 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 927666002998 S-adenosylmethionine binding site [chemical binding]; other site 927666002999 Predicted secreted protein [Function unknown]; Region: COG4086 927666003000 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 927666003001 C-terminal truncation, frameshift; conserved hypothetical protein 927666003002 Lysozyme-like; Region: Lysozyme_like; pfam13702 927666003003 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 927666003004 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 927666003005 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 927666003006 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 927666003007 dimer interface [polypeptide binding]; other site 927666003008 active site 927666003009 glycine-pyridoxal phosphate binding site [chemical binding]; other site 927666003010 folate binding site [chemical binding]; other site 927666003011 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 927666003012 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 927666003013 Coenzyme A binding pocket [chemical binding]; other site 927666003014 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 927666003015 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 927666003016 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 927666003017 S-adenosylmethionine binding site [chemical binding]; other site 927666003018 peptide chain release factor 1; Validated; Region: prfA; PRK00591 927666003019 This domain is found in peptide chain release factors; Region: PCRF; smart00937 927666003020 RF-1 domain; Region: RF-1; pfam00472 927666003021 thymidine kinase; Provisional; Region: PRK04296 927666003022 4-oxalocrotonate tautomerase; Provisional; Region: PRK02289 927666003023 active site 1 [active] 927666003024 dimer interface [polypeptide binding]; other site 927666003025 hexamer interface [polypeptide binding]; other site 927666003026 active site 2 [active] 927666003027 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 927666003028 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 927666003029 trmE is a tRNA modification GTPase; Region: trmE; cd04164 927666003030 G1 box; other site 927666003031 GTP/Mg2+ binding site [chemical binding]; other site 927666003032 Switch I region; other site 927666003033 G2 box; other site 927666003034 Switch II region; other site 927666003035 G3 box; other site 927666003036 G4 box; other site 927666003037 G5 box; other site 927666003038 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 927666003039 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 927666003040 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 927666003041 dimer interface [polypeptide binding]; other site 927666003042 active site 927666003043 catalytic residue [active] 927666003044 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 927666003045 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 927666003046 Predicted membrane protein [Function unknown]; Region: COG4708 927666003047 Predicted membrane protein [Function unknown]; Region: COG2246 927666003048 GtrA-like protein; Region: GtrA; pfam04138 927666003049 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 927666003050 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 927666003051 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 927666003052 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 927666003053 C-terminal domain interface [polypeptide binding]; other site 927666003054 active site 927666003055 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 927666003056 active site 927666003057 N-terminal domain interface [polypeptide binding]; other site 927666003058 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 927666003059 active site 927666003060 catalytic site [active] 927666003061 Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826 927666003062 active site 927666003063 catalytic site [active] 927666003064 T surface-antigen of pili; Region: FctA; cl16948 927666003065 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 927666003066 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 927666003067 Catalytic site [active] 927666003068 von Willebrand factor type A domain; Region: VWA_2; pfam13519 927666003069 peptidase T; Region: peptidase-T; TIGR01882 927666003070 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 927666003071 metal binding site [ion binding]; metal-binding site 927666003072 dimer interface [polypeptide binding]; other site 927666003073 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 927666003074 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 927666003075 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 927666003076 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 927666003077 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 927666003078 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 927666003079 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 927666003080 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 927666003081 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 927666003082 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 927666003083 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 927666003084 metal binding site [ion binding]; metal-binding site 927666003085 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 927666003086 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 927666003087 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 927666003088 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 927666003089 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 927666003090 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 927666003091 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 927666003092 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 927666003093 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 927666003094 dimerization domain swap beta strand [polypeptide binding]; other site 927666003095 regulatory protein interface [polypeptide binding]; other site 927666003096 active site 927666003097 regulatory phosphorylation site [posttranslational modification]; other site 927666003098 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 927666003099 catalytic residues [active] 927666003100 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 927666003101 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 927666003102 Class I ribonucleotide reductase; Region: RNR_I; cd01679 927666003103 active site 927666003104 dimer interface [polypeptide binding]; other site 927666003105 catalytic residues [active] 927666003106 effector binding site; other site 927666003107 R2 peptide binding site; other site 927666003108 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 927666003109 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 927666003110 dimer interface [polypeptide binding]; other site 927666003111 putative radical transfer pathway; other site 927666003112 diiron center [ion binding]; other site 927666003113 tyrosyl radical; other site 927666003114 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 927666003115 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 927666003116 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 927666003117 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 927666003118 beta-galactosidase; Region: BGL; TIGR03356 927666003119 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 927666003120 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 927666003121 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 927666003122 active site 927666003123 P-loop; other site 927666003124 phosphorylation site [posttranslational modification] 927666003125 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 927666003126 methionine cluster; other site 927666003127 active site 927666003128 phosphorylation site [posttranslational modification] 927666003129 metal binding site [ion binding]; metal-binding site 927666003130 CAT RNA binding domain; Region: CAT_RBD; smart01061 927666003131 transcriptional antiterminator BglG; Provisional; Region: PRK09772 927666003132 PRD domain; Region: PRD; pfam00874 927666003133 PRD domain; Region: PRD; pfam00874 927666003134 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 927666003135 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 927666003136 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 927666003137 putative substrate binding site [chemical binding]; other site 927666003138 putative ATP binding site [chemical binding]; other site 927666003139 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 927666003140 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 927666003141 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 927666003142 active site 927666003143 catalytic residues [active] 927666003144 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 927666003145 PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611 927666003146 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 927666003147 active site 927666003148 P-loop; other site 927666003149 phosphorylation site [posttranslational modification] 927666003150 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 927666003151 active site 927666003152 phosphorylation site [posttranslational modification] 927666003153 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 927666003154 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 927666003155 active site 927666003156 metal-binding site 927666003157 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 927666003158 EamA-like transporter family; Region: EamA; pfam00892 927666003159 EamA-like transporter family; Region: EamA; pfam00892 927666003160 Phosphotransferase enzyme family; Region: APH; pfam01636 927666003161 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 927666003162 active site 927666003163 substrate binding site [chemical binding]; other site 927666003164 ATP binding site [chemical binding]; other site 927666003165 dimer interface [polypeptide binding]; other site 927666003166 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 927666003167 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 927666003168 putative NAD(P) binding site [chemical binding]; other site 927666003169 putative catalytic Zn binding site [ion binding]; other site 927666003170 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 927666003171 substrate binding site; other site 927666003172 dimer interface; other site 927666003173 hypothetical protein; Validated; Region: PRK00153 927666003174 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974 927666003175 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 927666003176 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 927666003177 putative active site [active] 927666003178 catalytic site [active] 927666003179 putative metal binding site [ion binding]; other site 927666003180 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 927666003181 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 927666003182 active site 927666003183 catalytic site [active] 927666003184 substrate binding site [chemical binding]; other site 927666003185 MarR family; Region: MarR_2; cl17246 927666003186 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 927666003187 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 927666003188 nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052 927666003189 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 927666003190 dimer interface [polypeptide binding]; other site 927666003191 ADP-ribose binding site [chemical binding]; other site 927666003192 active site 927666003193 nudix motif; other site 927666003194 metal binding site [ion binding]; metal-binding site 927666003195 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 927666003196 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 927666003197 Substrate binding site; other site 927666003198 Mg++ binding site; other site 927666003199 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 927666003200 active site 927666003201 substrate binding site [chemical binding]; other site 927666003202 CoA binding site [chemical binding]; other site 927666003203 PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis. PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b. Both domains are required for...; Region: GH25_PlyB-like; cd06523 927666003204 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 927666003205 active site 927666003206 Predicted membrane protein [Function unknown]; Region: COG2035 927666003207 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 927666003208 putative deacylase active site [active] 927666003209 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 927666003210 catalytic core [active] 927666003211 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 927666003212 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 927666003213 dimer interface [polypeptide binding]; other site 927666003214 putative anticodon binding site; other site 927666003215 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 927666003216 motif 1; other site 927666003217 active site 927666003218 motif 2; other site 927666003219 motif 3; other site 927666003220 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 927666003221 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 927666003222 substrate binding pocket [chemical binding]; other site 927666003223 membrane-bound complex binding site; other site 927666003224 hinge residues; other site 927666003225 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 927666003226 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 927666003227 Walker A/P-loop; other site 927666003228 ATP binding site [chemical binding]; other site 927666003229 Q-loop/lid; other site 927666003230 ABC transporter signature motif; other site 927666003231 Walker B; other site 927666003232 D-loop; other site 927666003233 H-loop/switch region; other site 927666003234 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 927666003235 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 927666003236 dimer interface [polypeptide binding]; other site 927666003237 conserved gate region; other site 927666003238 putative PBP binding loops; other site 927666003239 ABC-ATPase subunit interface; other site 927666003240 Collagen binding domain; Region: Collagen_bind; pfam05737 927666003241 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 927666003242 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 927666003243 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 927666003244 binding surface 927666003245 TPR motif; other site 927666003246 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 927666003247 Domain of unknown function DUF20; Region: UPF0118; pfam01594 927666003248 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 927666003249 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 927666003250 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 927666003251 gamma subunit interface [polypeptide binding]; other site 927666003252 epsilon subunit interface [polypeptide binding]; other site 927666003253 LBP interface [polypeptide binding]; other site 927666003254 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 927666003255 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 927666003256 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 927666003257 alpha subunit interaction interface [polypeptide binding]; other site 927666003258 Walker A motif; other site 927666003259 ATP binding site [chemical binding]; other site 927666003260 Walker B motif; other site 927666003261 inhibitor binding site; inhibition site 927666003262 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 927666003263 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 927666003264 core domain interface [polypeptide binding]; other site 927666003265 delta subunit interface [polypeptide binding]; other site 927666003266 epsilon subunit interface [polypeptide binding]; other site 927666003267 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 927666003268 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 927666003269 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 927666003270 beta subunit interaction interface [polypeptide binding]; other site 927666003271 Walker A motif; other site 927666003272 ATP binding site [chemical binding]; other site 927666003273 Walker B motif; other site 927666003274 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 927666003275 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 927666003276 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 927666003277 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 927666003278 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 927666003279 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 927666003280 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 927666003281 F0F1 ATP synthase subunit C; Provisional; Region: PRK13467 927666003282 Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357 927666003283 CHY zinc finger; Region: zf-CHY; pfam05495 927666003284 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 927666003285 Peptidase family U32; Region: Peptidase_U32; pfam01136 927666003286 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 927666003287 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 927666003288 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 927666003289 DNA-binding site [nucleotide binding]; DNA binding site 927666003290 UTRA domain; Region: UTRA; pfam07702 927666003291 GMP synthase; Reviewed; Region: guaA; PRK00074 927666003292 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 927666003293 AMP/PPi binding site [chemical binding]; other site 927666003294 candidate oxyanion hole; other site 927666003295 catalytic triad [active] 927666003296 potential glutamine specificity residues [chemical binding]; other site 927666003297 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 927666003298 ATP Binding subdomain [chemical binding]; other site 927666003299 Dimerization subdomain; other site 927666003300 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 927666003301 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 927666003302 Walker A/P-loop; other site 927666003303 ATP binding site [chemical binding]; other site 927666003304 Q-loop/lid; other site 927666003305 ABC transporter signature motif; other site 927666003306 Walker B; other site 927666003307 D-loop; other site 927666003308 H-loop/switch region; other site 927666003309 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 927666003310 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 927666003311 active site 927666003312 phosphorylation site [posttranslational modification] 927666003313 intermolecular recognition site; other site 927666003314 dimerization interface [polypeptide binding]; other site 927666003315 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 927666003316 DNA binding site [nucleotide binding] 927666003317 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 927666003318 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 927666003319 ATP binding site [chemical binding]; other site 927666003320 Mg2+ binding site [ion binding]; other site 927666003321 G-X-G motif; other site 927666003322 signal recognition particle protein; Provisional; Region: PRK10867 927666003323 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 927666003324 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 927666003325 P loop; other site 927666003326 GTP binding site [chemical binding]; other site 927666003327 Signal peptide binding domain; Region: SRP_SPB; pfam02978 927666003328 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 927666003329 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 927666003330 elongation factor Tu; Reviewed; Region: PRK00049 927666003331 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 927666003332 G1 box; other site 927666003333 GEF interaction site [polypeptide binding]; other site 927666003334 GTP/Mg2+ binding site [chemical binding]; other site 927666003335 Switch I region; other site 927666003336 G2 box; other site 927666003337 G3 box; other site 927666003338 Switch II region; other site 927666003339 G4 box; other site 927666003340 G5 box; other site 927666003341 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 927666003342 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 927666003343 Antibiotic Binding Site [chemical binding]; other site 927666003344 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 927666003345 Domain of unknown function DUF20; Region: UPF0118; pfam01594 927666003346 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 927666003347 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 927666003348 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 927666003349 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 927666003350 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 927666003351 catalytic residues [active] 927666003352 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 927666003353 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 927666003354 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 927666003355 active site 927666003356 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 927666003357 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 927666003358 DNA-binding site [nucleotide binding]; DNA binding site 927666003359 DRTGG domain; Region: DRTGG; pfam07085 927666003360 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 927666003361 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 927666003362 active site 2 [active] 927666003363 active site 1 [active] 927666003364 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 927666003365 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 927666003366 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 927666003367 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 927666003368 hinge; other site 927666003369 active site 927666003370 pyruvate kinase; Provisional; Region: PRK05826 927666003371 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 927666003372 domain interfaces; other site 927666003373 active site 927666003374 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 927666003375 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 927666003376 active site 927666003377 ADP/pyrophosphate binding site [chemical binding]; other site 927666003378 dimerization interface [polypeptide binding]; other site 927666003379 allosteric effector site; other site 927666003380 fructose-1,6-bisphosphate binding site; other site 927666003381 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279 927666003382 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 927666003383 active site 927666003384 PHP Thumb interface [polypeptide binding]; other site 927666003385 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 927666003386 generic binding surface II; other site 927666003387 generic binding surface I; other site 927666003388 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 927666003389 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; pfam09168 927666003390 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 927666003391 Arginine repressor [Transcription]; Region: ArgR; COG1438 927666003392 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 927666003393 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 927666003394 GTPase CgtA; Reviewed; Region: obgE; PRK12297 927666003395 GTP1/OBG; Region: GTP1_OBG; pfam01018 927666003396 Obg GTPase; Region: Obg; cd01898 927666003397 G1 box; other site 927666003398 GTP/Mg2+ binding site [chemical binding]; other site 927666003399 Switch I region; other site 927666003400 G2 box; other site 927666003401 G3 box; other site 927666003402 Switch II region; other site 927666003403 G4 box; other site 927666003404 G5 box; other site 927666003405 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 927666003406 Protein of unknown function (DUF4044); Region: DUF4044; pfam13253 927666003407 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 927666003408 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 927666003409 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 927666003410 putative ADP-binding pocket [chemical binding]; other site 927666003411 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 927666003412 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 927666003413 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 927666003414 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 927666003415 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 927666003416 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 927666003417 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 927666003418 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 927666003419 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 927666003420 DNA binding residues [nucleotide binding] 927666003421 DNA primase; Validated; Region: dnaG; PRK05667 927666003422 CHC2 zinc finger; Region: zf-CHC2; pfam01807 927666003423 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 927666003424 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 927666003425 active site 927666003426 metal binding site [ion binding]; metal-binding site 927666003427 interdomain interaction site; other site 927666003428 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 927666003429 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 927666003430 Walker A/P-loop; other site 927666003431 ATP binding site [chemical binding]; other site 927666003432 Q-loop/lid; other site 927666003433 ABC transporter signature motif; other site 927666003434 Walker B; other site 927666003435 D-loop; other site 927666003436 H-loop/switch region; other site 927666003437 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 927666003438 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 927666003439 TM-ABC transporter signature motif; other site 927666003440 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 927666003441 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 927666003442 zinc binding site [ion binding]; other site 927666003443 putative ligand binding site [chemical binding]; other site 927666003444 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 927666003445 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 927666003446 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 927666003447 foldase protein PrsA; Reviewed; Region: prsA; PRK01326 927666003448 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 927666003449 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 927666003450 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 927666003451 S-adenosylmethionine binding site [chemical binding]; other site 927666003452 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 927666003453 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 927666003454 active site 927666003455 Zn binding site [ion binding]; other site 927666003456 Competence protein CoiA-like family; Region: CoiA; cl11541 927666003457 tellurite resistance protein TehB; Provisional; Region: PRK12335 927666003458 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 927666003459 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 927666003460 S-adenosylmethionine binding site [chemical binding]; other site 927666003461 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 927666003462 SmpB-tmRNA interface; other site 927666003463 ribonuclease R; Region: RNase_R; TIGR02063 927666003464 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 927666003465 RNB domain; Region: RNB; pfam00773 927666003466 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 927666003467 RNA binding site [nucleotide binding]; other site 927666003468 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 927666003469 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 927666003470 drug efflux system protein MdtG; Provisional; Region: PRK09874 927666003471 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 927666003472 putative substrate translocation pore; other site 927666003473 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 927666003474 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 927666003475 CoA-binding site [chemical binding]; other site 927666003476 ATP-binding [chemical binding]; other site 927666003477 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 927666003478 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 927666003479 DNA binding site [nucleotide binding] 927666003480 catalytic residue [active] 927666003481 H2TH interface [polypeptide binding]; other site 927666003482 putative catalytic residues [active] 927666003483 turnover-facilitating residue; other site 927666003484 intercalation triad [nucleotide binding]; other site 927666003485 8OG recognition residue [nucleotide binding]; other site 927666003486 putative reading head residues; other site 927666003487 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 927666003488 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 927666003489 GTPase Era; Reviewed; Region: era; PRK00089 927666003490 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 927666003491 G1 box; other site 927666003492 GTP/Mg2+ binding site [chemical binding]; other site 927666003493 Switch I region; other site 927666003494 G2 box; other site 927666003495 Switch II region; other site 927666003496 G3 box; other site 927666003497 G4 box; other site 927666003498 G5 box; other site 927666003499 KH domain; Region: KH_2; pfam07650 927666003500 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 927666003501 metal-binding heat shock protein; Provisional; Region: PRK00016 927666003502 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 927666003503 Domain of unknown function (DUF814); Region: DUF814; pfam05670 927666003504 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 927666003505 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 927666003506 Cl- selectivity filter; other site 927666003507 Cl- binding residues [ion binding]; other site 927666003508 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 927666003509 pore gating glutamate residue; other site 927666003510 dimer interface [polypeptide binding]; other site 927666003511 purine nucleoside phosphorylase; Provisional; Region: PRK08202 927666003512 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 927666003513 phosphopentomutase; Provisional; Region: PRK05362 927666003514 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 927666003515 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 927666003516 tetramer (dimer of dimers) interface [polypeptide binding]; other site 927666003517 active site 927666003518 dimer interface [polypeptide binding]; other site 927666003519 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 927666003520 Peptidase family U32; Region: Peptidase_U32; pfam01136 927666003521 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 927666003522 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 927666003523 Walker A/P-loop; other site 927666003524 ATP binding site [chemical binding]; other site 927666003525 Q-loop/lid; other site 927666003526 ABC transporter signature motif; other site 927666003527 Walker B; other site 927666003528 D-loop; other site 927666003529 H-loop/switch region; other site 927666003530 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 927666003531 Protein of unknown function (DUF3270); Region: DUF3270; pfam11674 927666003532 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 927666003533 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 927666003534 dimer interface [polypeptide binding]; other site 927666003535 phosphorylation site [posttranslational modification] 927666003536 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 927666003537 ATP binding site [chemical binding]; other site 927666003538 Mg2+ binding site [ion binding]; other site 927666003539 G-X-G motif; other site 927666003540 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 927666003541 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 927666003542 active site 927666003543 phosphorylation site [posttranslational modification] 927666003544 intermolecular recognition site; other site 927666003545 dimerization interface [polypeptide binding]; other site 927666003546 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 927666003547 DNA binding site [nucleotide binding] 927666003548 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 927666003549 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 927666003550 Zn binding site [ion binding]; other site 927666003551 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 927666003552 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 927666003553 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 927666003554 nudix motif; other site 927666003555 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 927666003556 classical (c) SDRs; Region: SDR_c; cd05233 927666003557 NAD(P) binding site [chemical binding]; other site 927666003558 active site 927666003559 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 927666003560 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 927666003561 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 927666003562 active site 927666003563 catalytic tetrad [active] 927666003564 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 927666003565 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 927666003566 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 927666003567 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 927666003568 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 927666003569 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 927666003570 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 927666003571 heterodimer interface [polypeptide binding]; other site 927666003572 active site 927666003573 FMN binding site [chemical binding]; other site 927666003574 homodimer interface [polypeptide binding]; other site 927666003575 substrate binding site [chemical binding]; other site 927666003576 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 927666003577 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 927666003578 FAD binding pocket [chemical binding]; other site 927666003579 FAD binding motif [chemical binding]; other site 927666003580 phosphate binding motif [ion binding]; other site 927666003581 beta-alpha-beta structure motif; other site 927666003582 NAD binding pocket [chemical binding]; other site 927666003583 Iron coordination center [ion binding]; other site 927666003584 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 927666003585 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 927666003586 dimer interface [polypeptide binding]; other site 927666003587 active site 927666003588 metal binding site [ion binding]; metal-binding site 927666003589 glutathione binding site [chemical binding]; other site 927666003590 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 927666003591 HSP70 interaction site [polypeptide binding]; other site 927666003592 Hsp70 protein; Region: HSP70; pfam00012 927666003593 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 927666003594 nucleotide binding site [chemical binding]; other site 927666003595 putative NEF/HSP70 interaction site [polypeptide binding]; other site 927666003596 SBD interface [polypeptide binding]; other site 927666003597 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 927666003598 23S rRNA binding site [nucleotide binding]; other site 927666003599 L21 binding site [polypeptide binding]; other site 927666003600 L13 binding site [polypeptide binding]; other site 927666003601 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 927666003602 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 927666003603 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 927666003604 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 927666003605 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 927666003606 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 927666003607 Competence protein; Region: Competence; pfam03772 927666003608 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 927666003609 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 927666003610 SLBB domain; Region: SLBB; pfam10531 927666003611 comEA protein; Region: comE; TIGR01259 927666003612 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 927666003613 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 927666003614 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 927666003615 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 927666003616 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 927666003617 hexamer interface [polypeptide binding]; other site 927666003618 ligand binding site [chemical binding]; other site 927666003619 putative active site [active] 927666003620 NAD(P) binding site [chemical binding]; other site 927666003621 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 927666003622 PhoH-like protein; Region: PhoH; pfam02562 927666003623 hypothetical protein; Provisional; Region: PRK13672 927666003624 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 927666003625 S1 domain; Region: S1_2; pfam13509 927666003626 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 927666003627 ribosome recycling factor; Reviewed; Region: frr; PRK00083 927666003628 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 927666003629 hinge region; other site 927666003630 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 927666003631 putative nucleotide binding site [chemical binding]; other site 927666003632 uridine monophosphate binding site [chemical binding]; other site 927666003633 homohexameric interface [polypeptide binding]; other site 927666003634 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 927666003635 Glucose inhibited division protein A; Region: GIDA; pfam01134 927666003636 Predicted methyltransferases [General function prediction only]; Region: COG0313 927666003637 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 927666003638 putative SAM binding site [chemical binding]; other site 927666003639 putative homodimer interface [polypeptide binding]; other site 927666003640 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 927666003641 DNA polymerase III subunit delta'; Validated; Region: PRK07276 927666003642 DNA polymerase III subunit delta'; Validated; Region: PRK08485 927666003643 thymidylate kinase; Validated; Region: tmk; PRK00698 927666003644 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 927666003645 TMP-binding site; other site 927666003646 ATP-binding site [chemical binding]; other site 927666003647 pyrroline-5-carboxylate reductase; Region: PLN02688 927666003648 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 927666003649 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 927666003650 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 927666003651 putative catalytic cysteine [active] 927666003652 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 927666003653 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 927666003654 nucleotide binding site [chemical binding]; other site 927666003655 homotetrameric interface [polypeptide binding]; other site 927666003656 putative phosphate binding site [ion binding]; other site 927666003657 putative allosteric binding site; other site 927666003658 PUA domain; Region: PUA; pfam01472 927666003659 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 927666003660 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 927666003661 RNA binding surface [nucleotide binding]; other site 927666003662 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 927666003663 active site 927666003664 lipoprotein signal peptidase; Provisional; Region: PRK14797 927666003665 Transcriptional regulator [Transcription]; Region: LysR; COG0583 927666003666 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 927666003667 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 927666003668 dimerization interface [polypeptide binding]; other site 927666003669 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 927666003670 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 927666003671 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 927666003672 Predicted membrane protein [Function unknown]; Region: COG3619 927666003673 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 927666003674 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 927666003675 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 927666003676 DEAD-like helicases superfamily; Region: DEXDc; smart00487 927666003677 ATP binding site [chemical binding]; other site 927666003678 putative Mg++ binding site [ion binding]; other site 927666003679 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 927666003680 nucleotide binding region [chemical binding]; other site 927666003681 ATP-binding site [chemical binding]; other site 927666003682 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 927666003683 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 927666003684 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 927666003685 Zn2+ binding site [ion binding]; other site 927666003686 Mg2+ binding site [ion binding]; other site 927666003687 sugar phosphate phosphatase; Provisional; Region: PRK10513 927666003688 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 927666003689 active site 927666003690 motif I; other site 927666003691 motif II; other site 927666003692 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 927666003693 Immunity protein Imm6; Region: Imm6; pfam14434 927666003694 Immunity protein Imm6; Region: Imm6; pfam14434 927666003695 Immunity protein Imm6; Region: Imm6; pfam14434 927666003696 Domain of unknown function (DUF4299); Region: DUF4299; pfam14132 927666003697 PQQ-like domain; Region: PQQ_2; pfam13360 927666003698 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 927666003699 Domain of unknown function (DUF4284); Region: DUF4284; pfam14112 927666003700 Domain of unknown function (DUF4274); Region: DUF4274; pfam14096 927666003701 Immunity protein Imm6; Region: Imm6; pfam14434 927666003702 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 927666003703 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 927666003704 CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cl13853 927666003705 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 927666003706 camphor resistance protein CrcB; Provisional; Region: PRK14229 927666003707 camphor resistance protein CrcB; Provisional; Region: PRK14221 927666003708 hypothetical protein; Provisional; Region: PRK07248 927666003709 flavodoxin; Validated; Region: PRK07308 927666003710 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 927666003711 DHH family; Region: DHH; pfam01368 927666003712 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 927666003713 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 927666003714 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 927666003715 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 927666003716 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 927666003717 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 927666003718 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 927666003719 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 927666003720 ATP-grasp domain; Region: ATP-grasp_4; cl17255 927666003721 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 927666003722 IMP binding site; other site 927666003723 dimer interface [polypeptide binding]; other site 927666003724 interdomain contacts; other site 927666003725 partial ornithine binding site; other site 927666003726 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 927666003727 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 927666003728 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 927666003729 catalytic site [active] 927666003730 subunit interface [polypeptide binding]; other site 927666003731 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 927666003732 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 927666003733 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 927666003734 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 927666003735 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 927666003736 active site 927666003737 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 927666003738 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 927666003739 minor groove reading motif; other site 927666003740 helix-hairpin-helix signature motif; other site 927666003741 substrate binding pocket [chemical binding]; other site 927666003742 active site 927666003743 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 927666003744 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 927666003745 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 927666003746 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 927666003747 GTP/Mg2+ binding site [chemical binding]; other site 927666003748 G4 box; other site 927666003749 G5 box; other site 927666003750 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 927666003751 G1 box; other site 927666003752 CAAX protease self-immunity; Region: Abi; pfam02517 927666003753 heat shock protein HtpX; Provisional; Region: PRK04897 927666003754 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 927666003755 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 927666003756 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 927666003757 S-adenosylmethionine binding site [chemical binding]; other site 927666003758 uracil transporter; Provisional; Region: PRK10720 927666003759 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 927666003760 EamA-like transporter family; Region: EamA; pfam00892 927666003761 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 927666003762 Beta-lactamase; Region: Beta-lactamase; pfam00144 927666003763 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 927666003764 active site 927666003765 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 927666003766 amphipathic channel; other site 927666003767 Asn-Pro-Ala signature motifs; other site 927666003768 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 927666003769 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 927666003770 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 927666003771 Putative esterase; Region: Esterase; pfam00756 927666003772 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 927666003773 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 927666003774 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 927666003775 Ligand Binding Site [chemical binding]; other site 927666003776 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 927666003777 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 927666003778 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 927666003779 catalytic residue [active] 927666003780 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 927666003781 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 927666003782 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 927666003783 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 927666003784 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 927666003785 active site 927666003786 phosphorylation site [posttranslational modification] 927666003787 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 927666003788 active site 927666003789 P-loop; other site 927666003790 phosphorylation site [posttranslational modification] 927666003791 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 927666003792 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 927666003793 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 927666003794 putative substrate binding site [chemical binding]; other site 927666003795 putative ATP binding site [chemical binding]; other site 927666003796 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 927666003797 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 927666003798 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 927666003799 NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841 927666003800 active site 927666003801 catalytic triad [active] 927666003802 oxyanion hole [active] 927666003803 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 927666003804 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 927666003805 active site 927666003806 motif I; other site 927666003807 motif II; other site 927666003808 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 927666003809 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 927666003810 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 927666003811 putative active site [active] 927666003812 putative metal binding site [ion binding]; other site 927666003813 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 927666003814 active site 927666003815 catalytic residues [active] 927666003816 metal binding site [ion binding]; metal-binding site 927666003817 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 927666003818 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 927666003819 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 927666003820 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 927666003821 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 927666003822 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 927666003823 Protein of unknown function (DUF4059); Region: DUF4059; pfam13268 927666003824 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 927666003825 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 927666003826 Walker A/P-loop; other site 927666003827 ATP binding site [chemical binding]; other site 927666003828 Q-loop/lid; other site 927666003829 ABC transporter signature motif; other site 927666003830 Walker B; other site 927666003831 D-loop; other site 927666003832 H-loop/switch region; other site 927666003833 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 927666003834 dimer interface [polypeptide binding]; other site 927666003835 conserved gate region; other site 927666003836 putative PBP binding loops; other site 927666003837 ABC-ATPase subunit interface; other site 927666003838 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 927666003839 ArsC family; Region: ArsC; pfam03960 927666003840 putative ArsC-like catalytic residues; other site 927666003841 putative TRX-like catalytic residues [active] 927666003842 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 927666003843 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 927666003844 DNA binding site [nucleotide binding] 927666003845 active site 927666003846 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 927666003847 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 927666003848 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 927666003849 imidazole glycerol phosphate synthase subunit hisH; Provisional; Region: hisH; CHL00188 927666003850 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 927666003851 predicted active site [active] 927666003852 catalytic triad [active] 927666003853 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 927666003854 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 927666003855 active site 927666003856 multimer interface [polypeptide binding]; other site 927666003857 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 927666003858 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 927666003859 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 927666003860 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 927666003861 ApbE family; Region: ApbE; pfam02424 927666003862 Predicted flavoprotein [General function prediction only]; Region: COG0431 927666003863 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 927666003864 Predicted flavoprotein [General function prediction only]; Region: COG0431 927666003865 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 927666003866 PAS domain; Region: PAS_10; pfam13596 927666003867 hypothetical protein; Provisional; Region: PRK02539 927666003868 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 927666003869 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 927666003870 DALR anticodon binding domain; Region: DALR_1; pfam05746 927666003871 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 927666003872 dimer interface [polypeptide binding]; other site 927666003873 motif 1; other site 927666003874 active site 927666003875 motif 2; other site 927666003876 motif 3; other site 927666003877 Uncharacterized conserved protein [Function unknown]; Region: COG3791 927666003878 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 927666003879 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 927666003880 putative active site [active] 927666003881 catalytic triad [active] 927666003882 PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133 927666003883 PA/protease domain interface [polypeptide binding]; other site 927666003884 putative integrin binding motif; other site 927666003885 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 927666003886 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 927666003887 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 927666003888 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 927666003889 active site 927666003890 catalytic tetrad [active] 927666003891 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 927666003892 Catalytic NodB homology domain of Streptococcus pneumoniae peptidoglycan deacetylase PgdA, Bacillus subtilis BsYjeA protein, and their bacterial homologs; Region: CE4_SpPgdA_BsYjeA_like; cd10947 927666003893 NodB motif; other site 927666003894 active site 927666003895 catalytic site [active] 927666003896 Zn binding site [ion binding]; other site 927666003897 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 927666003898 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 927666003899 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 927666003900 Mg2+ binding site [ion binding]; other site 927666003901 G-X-G motif; other site 927666003902 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 927666003903 anchoring element; other site 927666003904 dimer interface [polypeptide binding]; other site 927666003905 ATP binding site [chemical binding]; other site 927666003906 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 927666003907 active site 927666003908 putative metal-binding site [ion binding]; other site 927666003909 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 927666003910 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 927666003911 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 927666003912 motif II; other site 927666003913 Glycosyl hydrolase family 70; Region: Glyco_hydro_70; pfam02324 927666003914 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 927666003915 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 927666003916 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 927666003917 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 927666003918 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 927666003919 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 927666003920 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 927666003921 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 927666003922 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 927666003923 non-specific DNA binding site [nucleotide binding]; other site 927666003924 salt bridge; other site 927666003925 sequence-specific DNA binding site [nucleotide binding]; other site 927666003926 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 927666003927 DJ-1 family protein; Region: not_thiJ; TIGR01383 927666003928 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 927666003929 conserved cys residue [active] 927666003930 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 927666003931 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK07246 927666003932 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 927666003933 active site 927666003934 catalytic site [active] 927666003935 substrate binding site [chemical binding]; other site 927666003936 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 927666003937 ATP binding site [chemical binding]; other site 927666003938 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 927666003939 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 927666003940 putative substrate binding site [chemical binding]; other site 927666003941 putative ATP binding site [chemical binding]; other site 927666003942 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 927666003943 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 927666003944 active site 927666003945 motif I; other site 927666003946 motif II; other site 927666003947 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179 927666003948 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 927666003949 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 927666003950 homodimer interface [polypeptide binding]; other site 927666003951 NADP binding site [chemical binding]; other site 927666003952 substrate binding site [chemical binding]; other site 927666003953 TfoX N-terminal domain; Region: TfoX_N; pfam04993 927666003954 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 927666003955 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 927666003956 Walker A/P-loop; other site 927666003957 ATP binding site [chemical binding]; other site 927666003958 Q-loop/lid; other site 927666003959 ABC transporter signature motif; other site 927666003960 Walker B; other site 927666003961 D-loop; other site 927666003962 H-loop/switch region; other site 927666003963 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 927666003964 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 927666003965 dimer interface [polypeptide binding]; other site 927666003966 conserved gate region; other site 927666003967 putative PBP binding loops; other site 927666003968 ABC-ATPase subunit interface; other site 927666003969 Protein of unknown function (DUF1797); Region: DUF1797; cl11550 927666003970 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 927666003971 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 927666003972 Walker A motif; other site 927666003973 ATP binding site [chemical binding]; other site 927666003974 Walker B motif; other site 927666003975 arginine finger; other site 927666003976 UvrB/uvrC motif; Region: UVR; pfam02151 927666003977 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 927666003978 Walker A motif; other site 927666003979 ATP binding site [chemical binding]; other site 927666003980 Walker B motif; other site 927666003981 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 927666003982 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 927666003983 Predicted transcriptional regulator [Transcription]; Region: COG2378 927666003984 HTH domain; Region: HTH_11; pfam08279 927666003985 WYL domain; Region: WYL; pfam13280 927666003986 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 927666003987 nudix motif; other site 927666003988 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 927666003989 S-adenosylmethionine synthetase; Validated; Region: PRK05250 927666003990 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 927666003991 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 927666003992 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 927666003993 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 927666003994 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 927666003995 metal ion-dependent adhesion site (MIDAS); other site 927666003996 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 927666003997 helicase 45; Provisional; Region: PTZ00424 927666003998 ATP binding site [chemical binding]; other site 927666003999 Mg++ binding site [ion binding]; other site 927666004000 motif III; other site 927666004001 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 927666004002 nucleotide binding region [chemical binding]; other site 927666004003 ATP-binding site [chemical binding]; other site 927666004004 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 927666004005 putative catalytic site [active] 927666004006 putative metal binding site [ion binding]; other site 927666004007 putative phosphate binding site [ion binding]; other site 927666004008 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 927666004009 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 927666004010 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 927666004011 active site turn [active] 927666004012 phosphorylation site [posttranslational modification] 927666004013 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 927666004014 HPr interaction site; other site 927666004015 glycerol kinase (GK) interaction site [polypeptide binding]; other site 927666004016 active site 927666004017 phosphorylation site [posttranslational modification] 927666004018 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 927666004019 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 927666004020 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 927666004021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 927666004022 Walker A/P-loop; other site 927666004023 ATP binding site [chemical binding]; other site 927666004024 Q-loop/lid; other site 927666004025 ABC transporter signature motif; other site 927666004026 Walker B; other site 927666004027 D-loop; other site 927666004028 H-loop/switch region; other site 927666004029 PCRF domain; Region: PCRF; pfam03462 927666004030 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 927666004031 RF-1 domain; Region: RF-1; pfam00472 927666004032 FOG: CBS domain [General function prediction only]; Region: COG0517 927666004033 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 927666004034 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 927666004035 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 927666004036 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 927666004037 Na binding site [ion binding]; other site 927666004038 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 927666004039 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 927666004040 active site 927666004041 metal-binding site 927666004042 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 927666004043 Phosphotransferase enzyme family; Region: APH; pfam01636 927666004044 active site 927666004045 ATP binding site [chemical binding]; other site 927666004046 substrate binding site [chemical binding]; other site 927666004047 dimer interface [polypeptide binding]; other site 927666004048 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 927666004049 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 927666004050 Walker A/P-loop; other site 927666004051 ATP binding site [chemical binding]; other site 927666004052 Q-loop/lid; other site 927666004053 ABC transporter signature motif; other site 927666004054 Walker B; other site 927666004055 D-loop; other site 927666004056 H-loop/switch region; other site 927666004057 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 927666004058 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 927666004059 Walker A/P-loop; other site 927666004060 ATP binding site [chemical binding]; other site 927666004061 Q-loop/lid; other site 927666004062 ABC transporter signature motif; other site 927666004063 Walker B; other site 927666004064 D-loop; other site 927666004065 H-loop/switch region; other site 927666004066 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 927666004067 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 927666004068 TM-ABC transporter signature motif; other site 927666004069 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 927666004070 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 927666004071 TM-ABC transporter signature motif; other site 927666004072 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 927666004073 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 927666004074 putative ligand binding site [chemical binding]; other site 927666004075 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453 927666004076 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 927666004077 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 927666004078 oligomer interface [polypeptide binding]; other site 927666004079 active site residues [active] 927666004080 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 927666004081 active site 927666004082 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 927666004083 catalytic motif [active] 927666004084 Zn binding site [ion binding]; other site 927666004085 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 927666004086 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 927666004087 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 927666004088 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 927666004089 HI0933-like protein; Region: HI0933_like; pfam03486 927666004090 Chromate resistance exported protein; Region: Chrome_Resist; cl01744 927666004091 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 927666004092 putative active site [active] 927666004093 nucleotide binding site [chemical binding]; other site 927666004094 nudix motif; other site 927666004095 putative metal binding site [ion binding]; other site 927666004096 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 927666004097 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 927666004098 DNA binding residues [nucleotide binding] 927666004099 dimer interface [polypeptide binding]; other site 927666004100 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 927666004101 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 927666004102 Na2 binding site [ion binding]; other site 927666004103 putative substrate binding site 1 [chemical binding]; other site 927666004104 Na binding site 1 [ion binding]; other site 927666004105 putative substrate binding site 2 [chemical binding]; other site 927666004106 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 927666004107 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 927666004108 Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083 927666004109 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 927666004110 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 927666004111 active site 927666004112 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 927666004113 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 927666004114 PYR/PP interface [polypeptide binding]; other site 927666004115 dimer interface [polypeptide binding]; other site 927666004116 tetramer interface [polypeptide binding]; other site 927666004117 TPP binding site [chemical binding]; other site 927666004118 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 927666004119 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 927666004120 TPP-binding site [chemical binding]; other site 927666004121 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 927666004122 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 927666004123 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 927666004124 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 927666004125 Plastocyanin domain containing protein [General function prediction only]; Region: COG4633 927666004126 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 927666004127 Predicted transcriptional regulator [Transcription]; Region: COG3682 927666004128 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 927666004129 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 927666004130 dimer interface [polypeptide binding]; other site 927666004131 substrate binding site [chemical binding]; other site 927666004132 ATP binding site [chemical binding]; other site 927666004133 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 927666004134 thiamine phosphate binding site [chemical binding]; other site 927666004135 active site 927666004136 pyrophosphate binding site [ion binding]; other site 927666004137 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 927666004138 substrate binding site [chemical binding]; other site 927666004139 multimerization interface [polypeptide binding]; other site 927666004140 ATP binding site [chemical binding]; other site 927666004141 Predicted membrane protein [Function unknown]; Region: COG4732 927666004142 Putative transcription activator [Transcription]; Region: TenA; COG0819 927666004143 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 927666004144 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 927666004145 Walker A/P-loop; other site 927666004146 ATP binding site [chemical binding]; other site 927666004147 Q-loop/lid; other site 927666004148 ABC transporter signature motif; other site 927666004149 Walker B; other site 927666004150 D-loop; other site 927666004151 H-loop/switch region; other site 927666004152 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 927666004153 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 927666004154 Walker A/P-loop; other site 927666004155 ATP binding site [chemical binding]; other site 927666004156 Q-loop/lid; other site 927666004157 ABC transporter signature motif; other site 927666004158 Walker B; other site 927666004159 D-loop; other site 927666004160 H-loop/switch region; other site 927666004161 ABC-type cobalt transport system, permease component; Region: ABC_cobalt; cl01943 927666004162 Putative transcription activator [Transcription]; Region: TenA; COG0819 927666004163 L-lactate oxidase; Region: L_lactate_ox; TIGR02708 927666004164 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 927666004165 teramer interface [polypeptide binding]; other site 927666004166 active site 927666004167 FMN binding site [chemical binding]; other site 927666004168 catalytic residues [active] 927666004169 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 927666004170 active site 927666004171 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 927666004172 active site 927666004173 dimer interface [polypeptide binding]; other site 927666004174 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 927666004175 Cell division protein FtsQ; Region: FtsQ; pfam03799 927666004176 UDP-N-acetylglucosamine:LPS N-acetylglucosamine transferase [Cell envelope biogenesis, outer membrane]; Region: MurG; COG0707 927666004177 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 927666004178 homodimer interface [polypeptide binding]; other site 927666004179 active site 927666004180 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 927666004181 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 927666004182 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 927666004183 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 927666004184 Protein of unknown function (DUF3165); Region: DUF3165; pfam11364 927666004185 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 927666004186 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 927666004187 G1 box; other site 927666004188 putative GEF interaction site [polypeptide binding]; other site 927666004189 GTP/Mg2+ binding site [chemical binding]; other site 927666004190 Switch I region; other site 927666004191 G2 box; other site 927666004192 G3 box; other site 927666004193 Switch II region; other site 927666004194 G4 box; other site 927666004195 G5 box; other site 927666004196 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 927666004197 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 927666004198 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 927666004199 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 927666004200 RNA binding surface [nucleotide binding]; other site 927666004201 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 927666004202 active site 927666004203 uracil binding [chemical binding]; other site 927666004204 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 927666004205 active site residue [active] 927666004206 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 927666004207 Transcriptional regulator [Transcription]; Region: LysR; COG0583 927666004208 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 927666004209 dimerization interface [polypeptide binding]; other site 927666004210 LysR substrate binding domain; Region: LysR_substrate; pfam03466 927666004211 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 927666004212 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 927666004213 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 927666004214 active site 927666004215 metal binding site [ion binding]; metal-binding site 927666004216 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG3694 927666004217 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 927666004218 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 927666004219 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 927666004220 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 927666004221 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 927666004222 Walker A/P-loop; other site 927666004223 ATP binding site [chemical binding]; other site 927666004224 Q-loop/lid; other site 927666004225 ABC transporter signature motif; other site 927666004226 Walker B; other site 927666004227 D-loop; other site 927666004228 H-loop/switch region; other site 927666004229 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 927666004230 non-specific DNA binding site [nucleotide binding]; other site 927666004231 salt bridge; other site 927666004232 sequence-specific DNA binding site [nucleotide binding]; other site 927666004233 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 927666004234 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 927666004235 intersubunit interface [polypeptide binding]; other site 927666004236 active site 927666004237 zinc binding site [ion binding]; other site 927666004238 Na+ binding site [ion binding]; other site 927666004239 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 927666004240 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 927666004241 dimerization interface [polypeptide binding]; other site 927666004242 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 927666004243 dimer interface [polypeptide binding]; other site 927666004244 phosphorylation site [posttranslational modification] 927666004245 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 927666004246 ATP binding site [chemical binding]; other site 927666004247 Mg2+ binding site [ion binding]; other site 927666004248 G-X-G motif; other site 927666004249 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 927666004250 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 927666004251 active site 927666004252 phosphorylation site [posttranslational modification] 927666004253 intermolecular recognition site; other site 927666004254 dimerization interface [polypeptide binding]; other site 927666004255 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 927666004256 DNA binding site [nucleotide binding] 927666004257 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 927666004258 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 927666004259 FtsX-like permease family; Region: FtsX; pfam02687 927666004260 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 927666004261 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 927666004262 Walker A/P-loop; other site 927666004263 ATP binding site [chemical binding]; other site 927666004264 Q-loop/lid; other site 927666004265 ABC transporter signature motif; other site 927666004266 Walker B; other site 927666004267 D-loop; other site 927666004268 H-loop/switch region; other site 927666004269 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 927666004270 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 927666004271 FtsX-like permease family; Region: FtsX; pfam02687 927666004272 CAAX protease self-immunity; Region: Abi; pfam02517 927666004273 Isochorismatase family; Region: Isochorismatase; pfam00857 927666004274 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 927666004275 catalytic triad [active] 927666004276 conserved cis-peptide bond; other site 927666004277 Pleiotropic transcriptional repressor [Transcription]; Region: CodY; COG4465 927666004278 CodY GAF-like domain; Region: CodY; pfam06018 927666004279 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 927666004280 putative DNA binding site [nucleotide binding]; other site 927666004281 putative Zn2+ binding site [ion binding]; other site 927666004282 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 927666004283 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 927666004284 ATP binding site [chemical binding]; other site 927666004285 Mg++ binding site [ion binding]; other site 927666004286 motif III; other site 927666004287 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 927666004288 nucleotide binding region [chemical binding]; other site 927666004289 ATP-binding site [chemical binding]; other site 927666004290 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 927666004291 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 927666004292 putative substrate translocation pore; other site 927666004293 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 927666004294 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 927666004295 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 927666004296 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 927666004297 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 927666004298 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 927666004299 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 927666004300 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 927666004301 catalytic triad [active] 927666004302 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 927666004303 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 927666004304 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 927666004305 active site 927666004306 Predicted membrane protein [Function unknown]; Region: COG4720 927666004307 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 927666004308 dimer interface [polypeptide binding]; other site 927666004309 substrate binding site [chemical binding]; other site 927666004310 ATP binding site [chemical binding]; other site 927666004311 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 927666004312 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 927666004313 dimerization interface 3.5A [polypeptide binding]; other site 927666004314 active site 927666004315 Major Facilitator Superfamily; Region: MFS_1; pfam07690 927666004316 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 927666004317 putative substrate translocation pore; other site 927666004318 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 927666004319 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 927666004320 PhnA protein; Region: PhnA; pfam03831 927666004321 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 927666004322 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 927666004323 dimerization interface [polypeptide binding]; other site 927666004324 DPS ferroxidase diiron center [ion binding]; other site 927666004325 ion pore; other site 927666004326 triosephosphate isomerase; Provisional; Region: PRK14567 927666004327 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 927666004328 substrate binding site [chemical binding]; other site 927666004329 dimer interface [polypeptide binding]; other site 927666004330 catalytic triad [active] 927666004331 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 927666004332 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 927666004333 Homoserine O-succinyltransferase; Region: HTS; pfam04204 927666004334 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 927666004335 proposed active site lysine [active] 927666004336 conserved cys residue [active] 927666004337 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 927666004338 active site 927666004339 Methyltransferase domain; Region: Methyltransf_31; pfam13847 927666004340 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 927666004341 S-adenosylmethionine binding site [chemical binding]; other site 927666004342 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 927666004343 mRNA/rRNA interface [nucleotide binding]; other site 927666004344 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 927666004345 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 927666004346 23S rRNA interface [nucleotide binding]; other site 927666004347 L7/L12 interface [polypeptide binding]; other site 927666004348 putative thiostrepton binding site; other site 927666004349 L25 interface [polypeptide binding]; other site 927666004350 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 927666004351 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 927666004352 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 927666004353 nucleotide binding site/active site [active] 927666004354 HIT family signature motif; other site 927666004355 catalytic residue [active] 927666004356 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 927666004357 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 927666004358 putative oligomer interface [polypeptide binding]; other site 927666004359 putative active site [active] 927666004360 metal binding site [ion binding]; metal-binding site 927666004361 Protein of unknown function (DUF1307); Region: DUF1307; cl01981 927666004362 Protein of unknown function (DUF1307); Region: DUF1307; cl01981 927666004363 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 927666004364 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 927666004365 active site residue [active] 927666004366 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 927666004367 putative uracil binding site [chemical binding]; other site 927666004368 putative active site [active] 927666004369 dipeptidase PepV; Reviewed; Region: PRK07318 927666004370 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 927666004371 active site 927666004372 metal binding site [ion binding]; metal-binding site 927666004373 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 927666004374 dimer interface [polypeptide binding]; other site 927666004375 FMN binding site [chemical binding]; other site 927666004376 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 927666004377 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 927666004378 active site 927666004379 metal binding site [ion binding]; metal-binding site 927666004380 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 927666004381 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 927666004382 GIY-YIG motif/motif A; other site 927666004383 active site 927666004384 catalytic site [active] 927666004385 putative DNA binding site [nucleotide binding]; other site 927666004386 metal binding site [ion binding]; metal-binding site 927666004387 UvrB/uvrC motif; Region: UVR; pfam02151 927666004388 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 927666004389 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 927666004390 active site 927666004391 Predicted esterase [General function prediction only]; Region: COG0627 927666004392 S-formylglutathione hydrolase; Region: PLN02442 927666004393 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 927666004394 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 927666004395 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 927666004396 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 927666004397 CHAP domain; Region: CHAP; pfam05257 927666004398 Surface antigen [General function prediction only]; Region: COG3942 927666004399 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 927666004400 DHH family; Region: DHH; pfam01368 927666004401 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 927666004402 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 927666004403 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 927666004404 Walker A/P-loop; other site 927666004405 ATP binding site [chemical binding]; other site 927666004406 Q-loop/lid; other site 927666004407 ABC transporter signature motif; other site 927666004408 Walker B; other site 927666004409 D-loop; other site 927666004410 H-loop/switch region; other site 927666004411 bifunctional adhesin/ABC transporter aspartate/glutamate-binding protein; Reviewed; Region: PRK11917 927666004412 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 927666004413 substrate binding pocket [chemical binding]; other site 927666004414 membrane-bound complex binding site; other site 927666004415 hinge residues; other site 927666004416 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 927666004417 dimer interface [polypeptide binding]; other site 927666004418 conserved gate region; other site 927666004419 putative PBP binding loops; other site 927666004420 ABC-ATPase subunit interface; other site 927666004421 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 927666004422 dimer interface [polypeptide binding]; other site 927666004423 conserved gate region; other site 927666004424 putative PBP binding loops; other site 927666004425 ABC-ATPase subunit interface; other site 927666004426 Predicted transcriptional regulator [Transcription]; Region: COG1959 927666004427 Transcriptional regulator; Region: Rrf2; pfam02082 927666004428 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 927666004429 active site 927666004430 metal binding site [ion binding]; metal-binding site 927666004431 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019 927666004432 active site 927666004433 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 927666004434 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 927666004435 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 927666004436 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 927666004437 active site 927666004438 dimer interface [polypeptide binding]; other site 927666004439 motif 1; other site 927666004440 motif 2; other site 927666004441 motif 3; other site 927666004442 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 927666004443 anticodon binding site; other site 927666004444 Domain of unknown function (DUF389); Region: DUF389; pfam04087 927666004445 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 927666004446 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 927666004447 ATP binding site [chemical binding]; other site 927666004448 Mg2+ binding site [ion binding]; other site 927666004449 G-X-G motif; other site 927666004450 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 927666004451 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 927666004452 active site 927666004453 phosphorylation site [posttranslational modification] 927666004454 intermolecular recognition site; other site 927666004455 dimerization interface [polypeptide binding]; other site 927666004456 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 927666004457 DNA binding site [nucleotide binding] 927666004458 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 927666004459 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 927666004460 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 927666004461 FAD binding pocket [chemical binding]; other site 927666004462 conserved FAD binding motif [chemical binding]; other site 927666004463 phosphate binding motif [ion binding]; other site 927666004464 beta-alpha-beta structure motif; other site 927666004465 NAD binding pocket [chemical binding]; other site 927666004466 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 927666004467 nucleophilic elbow; other site 927666004468 catalytic triad; other site 927666004469 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 927666004470 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 927666004471 CshA-type fibril repeat; Region: CshA_fibril_rpt; TIGR04225 927666004472 surface protein repeat SSSPR-51; Region: repeat_SSSPR51; TIGR04308 927666004473 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 927666004474 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 927666004475 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 927666004476 FAD binding pocket [chemical binding]; other site 927666004477 FAD binding motif [chemical binding]; other site 927666004478 phosphate binding motif [ion binding]; other site 927666004479 beta-alpha-beta structure motif; other site 927666004480 NAD binding pocket [chemical binding]; other site 927666004481 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 927666004482 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 927666004483 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 927666004484 active site 927666004485 Zn binding site [ion binding]; other site 927666004486 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 927666004487 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 927666004488 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 927666004489 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 927666004490 ABC-ATPase subunit interface; other site 927666004491 dimer interface [polypeptide binding]; other site 927666004492 putative PBP binding regions; other site 927666004493 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 927666004494 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 927666004495 metal binding site [ion binding]; metal-binding site 927666004496 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 927666004497 dimer interface [polypeptide binding]; other site 927666004498 catalytic triad [active] 927666004499 peroxidatic and resolving cysteines [active] 927666004500 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 927666004501 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 927666004502 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 927666004503 FeoA domain; Region: FeoA; pfam04023 927666004504 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 927666004505 putative active site [active] 927666004506 dimerization interface [polypeptide binding]; other site 927666004507 putative tRNAtyr binding site [nucleotide binding]; other site 927666004508 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 927666004509 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 927666004510 Zn2+ binding site [ion binding]; other site 927666004511 Mg2+ binding site [ion binding]; other site 927666004512 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 927666004513 synthetase active site [active] 927666004514 NTP binding site [chemical binding]; other site 927666004515 metal binding site [ion binding]; metal-binding site 927666004516 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 927666004517 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 927666004518 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 927666004519 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 927666004520 Walker A/P-loop; other site 927666004521 ATP binding site [chemical binding]; other site 927666004522 Q-loop/lid; other site 927666004523 ABC transporter signature motif; other site 927666004524 Walker B; other site 927666004525 D-loop; other site 927666004526 H-loop/switch region; other site 927666004527 TOBE domain; Region: TOBE_2; pfam08402 927666004528 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 927666004529 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 927666004530 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 927666004531 active site 927666004532 metal binding site [ion binding]; metal-binding site 927666004533 dimerization interface [polypeptide binding]; other site 927666004534 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 927666004535 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 927666004536 active site 927666004537 HIGH motif; other site 927666004538 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 927666004539 KMSKS motif; other site 927666004540 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 927666004541 tRNA binding surface [nucleotide binding]; other site 927666004542 anticodon binding site; other site 927666004543 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cl17426 927666004544 NADP+ binding site [chemical binding]; other site 927666004545 RibD C-terminal domain; Region: RibD_C; cl17279 927666004546 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 927666004547 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 927666004548 Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045 927666004549 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 927666004550 trimer interface [polypeptide binding]; other site 927666004551 active site 927666004552 substrate binding site [chemical binding]; other site 927666004553 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 927666004554 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 927666004555 RNase E interface [polypeptide binding]; other site 927666004556 trimer interface [polypeptide binding]; other site 927666004557 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 927666004558 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 927666004559 RNase E interface [polypeptide binding]; other site 927666004560 trimer interface [polypeptide binding]; other site 927666004561 active site 927666004562 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 927666004563 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 927666004564 RNA binding site [nucleotide binding]; other site 927666004565 domain interface; other site 927666004566 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 927666004567 FAD binding site [chemical binding]; other site 927666004568 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 927666004569 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 927666004570 THF binding site; other site 927666004571 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 927666004572 substrate binding site [chemical binding]; other site 927666004573 THF binding site; other site 927666004574 zinc-binding site [ion binding]; other site 927666004575 conserved hypothetical protein; Region: TIGR02328 927666004576 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013 927666004577 Protein of unknown function (DUF1722); Region: DUF1722; pfam08349 927666004578 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 927666004579 non-specific DNA binding site [nucleotide binding]; other site 927666004580 salt bridge; other site 927666004581 sequence-specific DNA binding site [nucleotide binding]; other site 927666004582 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 927666004583 active site 927666004584 DEAD-like helicases superfamily; Region: DEXDc; smart00487 927666004585 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 927666004586 ATP binding site [chemical binding]; other site 927666004587 putative Mg++ binding site [ion binding]; other site 927666004588 helicase superfamily c-terminal domain; Region: HELICc; smart00490 927666004589 ATP-binding site [chemical binding]; other site 927666004590 Uncharacterized conserved protein [Function unknown]; Region: COG0398 927666004591 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 927666004592 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 927666004593 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 927666004594 nucleotide binding site [chemical binding]; other site 927666004595 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 927666004596 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 927666004597 active site turn [active] 927666004598 phosphorylation site [posttranslational modification] 927666004599 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 927666004600 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 927666004601 HPr interaction site; other site 927666004602 glycerol kinase (GK) interaction site [polypeptide binding]; other site 927666004603 active site 927666004604 phosphorylation site [posttranslational modification] 927666004605 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 927666004606 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 927666004607 substrate binding [chemical binding]; other site 927666004608 active site 927666004609 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 927666004610 Transcriptional regulators [Transcription]; Region: PurR; COG1609 927666004611 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 927666004612 DNA binding site [nucleotide binding] 927666004613 domain linker motif; other site 927666004614 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 927666004615 dimerization interface [polypeptide binding]; other site 927666004616 ligand binding site [chemical binding]; other site 927666004617 sodium binding site [ion binding]; other site 927666004618 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 927666004619 homodimer interface [polypeptide binding]; other site 927666004620 catalytic residues [active] 927666004621 NAD binding site [chemical binding]; other site 927666004622 substrate binding pocket [chemical binding]; other site 927666004623 flexible flap; other site 927666004624 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 927666004625 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 927666004626 dimer interface [polypeptide binding]; other site 927666004627 active site 927666004628 Uncharacterized conserved protein [Function unknown]; Region: COG3610 927666004629 Uncharacterized conserved protein [Function unknown]; Region: COG2966 927666004630 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 927666004631 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 927666004632 Catalytic domain of Protein Kinases; Region: PKc; cd00180 927666004633 active site 927666004634 ATP binding site [chemical binding]; other site 927666004635 substrate binding site [chemical binding]; other site 927666004636 activation loop (A-loop); other site 927666004637 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 927666004638 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 927666004639 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 927666004640 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 927666004641 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 927666004642 active site 927666004643 16S rRNA methyltransferase B; Provisional; Region: PRK14902 927666004644 NusB family; Region: NusB; pfam01029 927666004645 putative RNA binding site [nucleotide binding]; other site 927666004646 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 927666004647 S-adenosylmethionine binding site [chemical binding]; other site 927666004648 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 927666004649 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 927666004650 putative active site [active] 927666004651 substrate binding site [chemical binding]; other site 927666004652 putative cosubstrate binding site; other site 927666004653 catalytic site [active] 927666004654 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 927666004655 substrate binding site [chemical binding]; other site 927666004656 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 927666004657 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 927666004658 ATP binding site [chemical binding]; other site 927666004659 putative Mg++ binding site [ion binding]; other site 927666004660 helicase superfamily c-terminal domain; Region: HELICc; smart00490 927666004661 nucleotide binding region [chemical binding]; other site 927666004662 ATP-binding site [chemical binding]; other site 927666004663 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 927666004664 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 927666004665 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 927666004666 catalytic site [active] 927666004667 G-X2-G-X-G-K; other site 927666004668 hypothetical protein; Provisional; Region: PRK00106 927666004669 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 927666004670 Zn2+ binding site [ion binding]; other site 927666004671 Mg2+ binding site [ion binding]; other site 927666004672 Cdc6-related protein, AAA superfamily ATPase [DNA replication, recombination, and repair / Posttranslational modification, protein turnover, chaperones]; Region: CDC6; COG1474 927666004673 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 927666004674 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 927666004675 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 927666004676 hypothetical protein; Provisional; Region: PRK13670 927666004677 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 927666004678 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 927666004679 S-adenosylmethionine binding site [chemical binding]; other site 927666004680 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 927666004681 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 927666004682 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 927666004683 Zn2+ binding site [ion binding]; other site 927666004684 Mg2+ binding site [ion binding]; other site 927666004685 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 927666004686 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 927666004687 active site 927666004688 (T/H)XGH motif; other site 927666004689 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 927666004690 GTPase YqeH; Provisional; Region: PRK13796 927666004691 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 927666004692 GTP/Mg2+ binding site [chemical binding]; other site 927666004693 G4 box; other site 927666004694 G5 box; other site 927666004695 G1 box; other site 927666004696 Switch I region; other site 927666004697 G2 box; other site 927666004698 G3 box; other site 927666004699 Switch II region; other site 927666004700 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 927666004701 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 927666004702 active site 927666004703 motif I; other site 927666004704 motif II; other site 927666004705 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 927666004706 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 927666004707 Cl binding site [ion binding]; other site 927666004708 oligomer interface [polypeptide binding]; other site 927666004709 Mechanosensitive ion channel; Region: MS_channel; pfam00924 927666004710 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 927666004711 serine/threonine transporter SstT; Provisional; Region: PRK13628 927666004712 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 927666004713 Predicted membrane protein [Function unknown]; Region: COG4129 927666004714 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 927666004715 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 927666004716 Protein of unknown function, DUF600; Region: DUF600; cl04640 927666004717 Protein of unknown function, DUF600; Region: DUF600; cl04640 927666004718 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 927666004719 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 927666004720 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 927666004721 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 927666004722 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 927666004723 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 927666004724 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 927666004725 nucleotide binding region [chemical binding]; other site 927666004726 ATP-binding site [chemical binding]; other site 927666004727 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 927666004728 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 927666004729 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 927666004730 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 927666004731 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417 927666004732 SecY translocase; Region: SecY; pfam00344 927666004733 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 927666004734 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 927666004735 Ligand binding site; other site 927666004736 metal-binding site 927666004737 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 927666004738 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 927666004739 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 927666004740 Ligand binding site; other site 927666004741 metal-binding site 927666004742 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 927666004743 serine-rich repeat adhesion glycoprotein AST domain; Region: ser_adhes_Nterm; TIGR04224 927666004744 Rib/alpha-like repeat; Region: Rib; cl07159 927666004745 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 927666004746 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 927666004747 G1 box; other site 927666004748 putative GEF interaction site [polypeptide binding]; other site 927666004749 GTP/Mg2+ binding site [chemical binding]; other site 927666004750 Switch I region; other site 927666004751 G2 box; other site 927666004752 G3 box; other site 927666004753 Switch II region; other site 927666004754 G4 box; other site 927666004755 G5 box; other site 927666004756 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 927666004757 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 927666004758 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 927666004759 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 927666004760 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 927666004761 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 927666004762 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 927666004763 GatB domain; Region: GatB_Yqey; pfam02637 927666004764 Tim44-like domain; Region: Tim44; cl09208 927666004765 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 927666004766 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 927666004767 elongation factor P; Validated; Region: PRK00529 927666004768 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 927666004769 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 927666004770 RNA binding site [nucleotide binding]; other site 927666004771 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 927666004772 RNA binding site [nucleotide binding]; other site 927666004773 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 927666004774 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 927666004775 putative RNA binding site [nucleotide binding]; other site 927666004776 CAAX protease self-immunity; Region: Abi; pfam02517 927666004777 CAAX protease self-immunity; Region: Abi; pfam02517 927666004778 acetyl-CoA carboxylase subunit alpha; Provisional; Region: PRK12319 927666004779 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 927666004780 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 927666004781 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 927666004782 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 927666004783 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 927666004784 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 927666004785 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 927666004786 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 927666004787 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 927666004788 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 927666004789 carboxyltransferase (CT) interaction site; other site 927666004790 biotinylation site [posttranslational modification]; other site 927666004791 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 927666004792 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 927666004793 dimer interface [polypeptide binding]; other site 927666004794 active site 927666004795 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 927666004796 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 927666004797 NAD(P) binding site [chemical binding]; other site 927666004798 homotetramer interface [polypeptide binding]; other site 927666004799 homodimer interface [polypeptide binding]; other site 927666004800 active site 927666004801 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 927666004802 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 927666004803 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 927666004804 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 927666004805 FMN binding site [chemical binding]; other site 927666004806 substrate binding site [chemical binding]; other site 927666004807 putative catalytic residue [active] 927666004808 acyl carrier protein; Provisional; Region: acpP; PRK00982 927666004809 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 927666004810 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 927666004811 dimer interface [polypeptide binding]; other site 927666004812 active site 927666004813 CoA binding pocket [chemical binding]; other site 927666004814 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 927666004815 MarR family; Region: MarR; pfam01047 927666004816 enoyl-CoA hydratase; Provisional; Region: PRK07260 927666004817 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 927666004818 substrate binding site [chemical binding]; other site 927666004819 oxyanion hole (OAH) forming residues; other site 927666004820 trimer interface [polypeptide binding]; other site 927666004821 aspartate kinase; Reviewed; Region: PRK09034 927666004822 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 927666004823 putative catalytic residues [active] 927666004824 putative nucleotide binding site [chemical binding]; other site 927666004825 putative aspartate binding site [chemical binding]; other site 927666004826 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 927666004827 allosteric regulatory residue; other site 927666004828 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 927666004829 Domain of unknown function (DUF956); Region: DUF956; pfam06115 927666004830 seryl-tRNA synthetase; Provisional; Region: PRK05431 927666004831 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 927666004832 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 927666004833 dimer interface [polypeptide binding]; other site 927666004834 active site 927666004835 motif 1; other site 927666004836 motif 2; other site 927666004837 motif 3; other site 927666004838 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 927666004839 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 927666004840 gating phenylalanine in ion channel; other site 927666004841 Uncharacterized conserved protein [Function unknown]; Region: COG2128 927666004842 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 927666004843 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 927666004844 amino acid carrier protein; Region: agcS; TIGR00835 927666004845 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: COG1193 927666004846 MutS domain III; Region: MutS_III; pfam05192 927666004847 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 927666004848 Walker A/P-loop; other site 927666004849 ATP binding site [chemical binding]; other site 927666004850 Q-loop/lid; other site 927666004851 ABC transporter signature motif; other site 927666004852 Walker B; other site 927666004853 D-loop; other site 927666004854 H-loop/switch region; other site 927666004855 Smr domain; Region: Smr; pfam01713 927666004856 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 927666004857 Colicin V production protein; Region: Colicin_V; pfam02674 927666004858 ribonuclease HIII; Provisional; Region: PRK00996 927666004859 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 927666004860 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 927666004861 RNA/DNA hybrid binding site [nucleotide binding]; other site 927666004862 active site 927666004863 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 927666004864 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 927666004865 Catalytic site [active] 927666004866 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 927666004867 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 927666004868 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 927666004869 DNA binding site [nucleotide binding] 927666004870 AAA domain; Region: AAA_30; pfam13604 927666004871 Family description; Region: UvrD_C_2; pfam13538 927666004872 trigger factor; Provisional; Region: tig; PRK01490 927666004873 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 927666004874 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 927666004875 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 927666004876 A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064 927666004877 active site 927666004878 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 927666004879 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 927666004880 active site 927666004881 phosphorylation site [posttranslational modification] 927666004882 intermolecular recognition site; other site 927666004883 dimerization interface [polypeptide binding]; other site 927666004884 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 927666004885 DNA binding residues [nucleotide binding] 927666004886 dimerization interface [polypeptide binding]; other site 927666004887 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 927666004888 Histidine kinase; Region: HisKA_3; pfam07730 927666004889 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 927666004890 ATP binding site [chemical binding]; other site 927666004891 Mg2+ binding site [ion binding]; other site 927666004892 G-X-G motif; other site 927666004893 Predicted membrane protein [Function unknown]; Region: COG4758 927666004894 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 927666004895 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 927666004896 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 927666004897 homotetramer interface [polypeptide binding]; other site 927666004898 FMN binding site [chemical binding]; other site 927666004899 homodimer contacts [polypeptide binding]; other site 927666004900 putative active site [active] 927666004901 putative substrate binding site [chemical binding]; other site 927666004902 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 927666004903 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 927666004904 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 927666004905 diphosphomevalonate decarboxylase; Region: PLN02407 927666004906 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 927666004907 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 927666004908 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 927666004909 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 927666004910 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 927666004911 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 927666004912 active site 927666004913 phosphorylation site [posttranslational modification] 927666004914 intermolecular recognition site; other site 927666004915 dimerization interface [polypeptide binding]; other site 927666004916 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 927666004917 DNA binding site [nucleotide binding] 927666004918 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 927666004919 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 927666004920 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 927666004921 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 927666004922 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 927666004923 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 927666004924 cell division protein GpsB; Provisional; Region: PRK14127 927666004925 DivIVA domain; Region: DivI1A_domain; TIGR03544 927666004926 hypothetical protein; Provisional; Region: PRK13660 927666004927 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 927666004928 Transglycosylase; Region: Transgly; pfam00912 927666004929 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 927666004930 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 927666004931 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 927666004932 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 927666004933 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 927666004934 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 927666004935 active site 927666004936 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 927666004937 beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555 927666004938 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 927666004939 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 927666004940 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 927666004941 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 927666004942 Endo-alpha-N-acetylgalactosaminidase; Region: Glyco_hydro_101; pfam12905 927666004943 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 927666004944 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 927666004945 NADP binding site [chemical binding]; other site 927666004946 active site 927666004947 putative substrate binding site [chemical binding]; other site 927666004948 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 927666004949 beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814 927666004950 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 927666004951 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 927666004952 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 927666004953 UDP-galactopyranose mutase; Region: GLF; pfam03275 927666004954 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 927666004955 Acyltransferase family; Region: Acyl_transf_3; pfam01757 927666004956 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 927666004957 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 927666004958 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 927666004959 active site 927666004960 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 927666004961 This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820 927666004962 putative ADP-binding pocket [chemical binding]; other site 927666004963 LicD family; Region: LicD; cl01378 927666004964 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 927666004965 Bacterial sugar transferase; Region: Bac_transf; pfam02397 927666004966 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 927666004967 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 927666004968 polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006 927666004969 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 927666004970 DNA polymerase processivity factor; Region: DNA_PPF; pfam02916 927666004971 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816 927666004972 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 927666004973 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 927666004974 peptide binding site [polypeptide binding]; other site 927666004975 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 927666004976 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 927666004977 peptide binding site [polypeptide binding]; other site 927666004978 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 927666004979 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 927666004980 Ca binding site [ion binding]; other site 927666004981 active site 927666004982 catalytic site [active] 927666004983 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 927666004984 hypothetical protein; Provisional; Region: PRK13663 927666004985 LuxS protein involved in autoinducer AI2 synthesis [Signal transduction mechanisms]; Region: LuxS; COG1854 927666004986 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 927666004987 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 927666004988 Walker A motif; other site 927666004989 ATP binding site [chemical binding]; other site 927666004990 Walker B motif; other site 927666004991 arginine finger; other site 927666004992 flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499 927666004993 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 927666004994 gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640 927666004995 Walker A motif; other site 927666004996 ATP binding site [chemical binding]; other site 927666004997 Walker B motif; other site 927666004998 arginine finger; other site 927666004999 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 927666005000 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 927666005001 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 927666005002 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 927666005003 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 927666005004 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 927666005005 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 927666005006 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 927666005007 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 927666005008 active site 927666005009 DNA polymerase IV; Validated; Region: PRK02406 927666005010 DNA binding site [nucleotide binding] 927666005011 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 927666005012 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 927666005013 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 927666005014 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 927666005015 substrate binding pocket [chemical binding]; other site 927666005016 membrane-bound complex binding site; other site 927666005017 hinge residues; other site 927666005018 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 927666005019 dimer interface [polypeptide binding]; other site 927666005020 conserved gate region; other site 927666005021 putative PBP binding loops; other site 927666005022 ABC-ATPase subunit interface; other site 927666005023 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 927666005024 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 927666005025 Walker A/P-loop; other site 927666005026 ATP binding site [chemical binding]; other site 927666005027 Q-loop/lid; other site 927666005028 ABC transporter signature motif; other site 927666005029 Walker B; other site 927666005030 D-loop; other site 927666005031 H-loop/switch region; other site 927666005032 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 927666005033 HflK protein; Region: hflK; TIGR01933 927666005034 threonine dehydratase; Validated; Region: PRK08639 927666005035 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 927666005036 tetramer interface [polypeptide binding]; other site 927666005037 pyridoxal 5'-phosphate binding site [chemical binding]; other site 927666005038 catalytic residue [active] 927666005039 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 927666005040 ketol-acid reductoisomerase; Provisional; Region: PRK05479 927666005041 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 927666005042 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 927666005043 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 927666005044 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 927666005045 putative valine binding site [chemical binding]; other site 927666005046 dimer interface [polypeptide binding]; other site 927666005047 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 927666005048 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07282 927666005049 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 927666005050 PYR/PP interface [polypeptide binding]; other site 927666005051 dimer interface [polypeptide binding]; other site 927666005052 TPP binding site [chemical binding]; other site 927666005053 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 927666005054 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 927666005055 TPP-binding site [chemical binding]; other site 927666005056 dimer interface [polypeptide binding]; other site 927666005057 elongation factor G; Reviewed; Region: PRK00007 927666005058 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 927666005059 G1 box; other site 927666005060 putative GEF interaction site [polypeptide binding]; other site 927666005061 GTP/Mg2+ binding site [chemical binding]; other site 927666005062 Switch I region; other site 927666005063 G2 box; other site 927666005064 G3 box; other site 927666005065 Switch II region; other site 927666005066 G4 box; other site 927666005067 G5 box; other site 927666005068 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 927666005069 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 927666005070 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 927666005071 30S ribosomal protein S7; Validated; Region: PRK05302 927666005072 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 927666005073 S17 interaction site [polypeptide binding]; other site 927666005074 S8 interaction site; other site 927666005075 16S rRNA interaction site [nucleotide binding]; other site 927666005076 streptomycin interaction site [chemical binding]; other site 927666005077 23S rRNA interaction site [nucleotide binding]; other site 927666005078 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 927666005079 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 927666005080 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 927666005081 active site 927666005082 phosphorylation site [posttranslational modification] 927666005083 intermolecular recognition site; other site 927666005084 dimerization interface [polypeptide binding]; other site 927666005085 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 927666005086 DNA binding residues [nucleotide binding] 927666005087 dimerization interface [polypeptide binding]; other site 927666005088 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 927666005089 Histidine kinase; Region: HisKA_3; pfam07730 927666005090 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 927666005091 ATP binding site [chemical binding]; other site 927666005092 Mg2+ binding site [ion binding]; other site 927666005093 G-X-G motif; other site 927666005094 ABC-2 type transporter; Region: ABC2_membrane; cl17235 927666005095 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 927666005096 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 927666005097 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 927666005098 Walker A/P-loop; other site 927666005099 ATP binding site [chemical binding]; other site 927666005100 Q-loop/lid; other site 927666005101 ABC transporter signature motif; other site 927666005102 Walker B; other site 927666005103 D-loop; other site 927666005104 H-loop/switch region; other site 927666005105 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 927666005106 DAK2 domain; Region: Dak2; pfam02734 927666005107 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 927666005108 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 927666005109 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 927666005110 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 927666005111 LytTr DNA-binding domain; Region: LytTR; pfam04397 927666005112 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 927666005113 active site 927666005114 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 927666005115 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 927666005116 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 927666005117 Walker A/P-loop; other site 927666005118 ATP binding site [chemical binding]; other site 927666005119 Q-loop/lid; other site 927666005120 ABC transporter signature motif; other site 927666005121 Walker B; other site 927666005122 D-loop; other site 927666005123 H-loop/switch region; other site 927666005124 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 927666005125 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 927666005126 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 927666005127 Walker A/P-loop; other site 927666005128 ATP binding site [chemical binding]; other site 927666005129 Q-loop/lid; other site 927666005130 ABC transporter signature motif; other site 927666005131 Walker B; other site 927666005132 D-loop; other site 927666005133 H-loop/switch region; other site 927666005134 MarR family; Region: MarR_2; pfam12802 927666005135 Transcriptional regulators [Transcription]; Region: MarR; COG1846 927666005136 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 927666005137 Short repeat of unknown function (DUF308); Region: DUF308; pfam03729 927666005138 hypothetical protein; Provisional; Region: PRK12378 927666005139 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 927666005140 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 927666005141 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 927666005142 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 927666005143 Coenzyme A binding pocket [chemical binding]; other site 927666005144 PspC domain; Region: PspC; pfam04024 927666005145 recombinase A; Provisional; Region: recA; PRK09354 927666005146 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 927666005147 hexamer interface [polypeptide binding]; other site 927666005148 Walker A motif; other site 927666005149 ATP binding site [chemical binding]; other site 927666005150 Walker B motif; other site 927666005151 competence damage-inducible protein A; Provisional; Region: PRK00549 927666005152 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 927666005153 putative MPT binding site; other site 927666005154 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 927666005155 Transcriptional regulator [Transcription]; Region: LytR; COG1316 927666005156 putative acetyltransferase YhhY; Provisional; Region: PRK10140 927666005157 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 927666005158 Coenzyme A binding pocket [chemical binding]; other site 927666005159 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 927666005160 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 927666005161 active site 927666005162 multimer interface [polypeptide binding]; other site 927666005163 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 927666005164 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 927666005165 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 927666005166 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 927666005167 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 927666005168 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 927666005169 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 927666005170 G-loop; other site 927666005171 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 927666005172 DNA binding site [nucleotide binding] 927666005173 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 927666005174 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 927666005175 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 927666005176 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 927666005177 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 927666005178 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 927666005179 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 927666005180 RPB1 interaction site [polypeptide binding]; other site 927666005181 RPB10 interaction site [polypeptide binding]; other site 927666005182 RPB11 interaction site [polypeptide binding]; other site 927666005183 RPB3 interaction site [polypeptide binding]; other site 927666005184 RPB12 interaction site [polypeptide binding]; other site 927666005185 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 927666005186 pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102 927666005187 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 927666005188 carbohydrate binding site [chemical binding]; other site 927666005189 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 927666005190 carbohydrate binding site [chemical binding]; other site 927666005191 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 927666005192 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 927666005193 Ca binding site [ion binding]; other site 927666005194 active site 927666005195 catalytic site [active] 927666005196 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 927666005197 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 927666005198 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 927666005199 Walker A/P-loop; other site 927666005200 ATP binding site [chemical binding]; other site 927666005201 Q-loop/lid; other site 927666005202 ABC transporter signature motif; other site 927666005203 Walker B; other site 927666005204 D-loop; other site 927666005205 H-loop/switch region; other site 927666005206 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 927666005207 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 927666005208 dimer interface [polypeptide binding]; other site 927666005209 conserved gate region; other site 927666005210 putative PBP binding loops; other site 927666005211 ABC-ATPase subunit interface; other site 927666005212 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 927666005213 dimer interface [polypeptide binding]; other site 927666005214 conserved gate region; other site 927666005215 putative PBP binding loops; other site 927666005216 ABC-ATPase subunit interface; other site 927666005217 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 927666005218 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 927666005219 substrate binding pocket [chemical binding]; other site 927666005220 membrane-bound complex binding site; other site 927666005221 hinge residues; other site 927666005222 The URO-D _like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases. Uroporphyrinogen decarboxylase (URO-D) decarboxylates the four...; Region: URO-D_like; cd03465 927666005223 The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464 927666005224 5'-nucleotidase, lipoprotein e(P4) family; Region: lipo_e_P4; TIGR01533 927666005225 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 927666005226 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 927666005227 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 927666005228 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 927666005229 glutaminase active site [active] 927666005230 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 927666005231 dimer interface [polypeptide binding]; other site 927666005232 active site 927666005233 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 927666005234 dimer interface [polypeptide binding]; other site 927666005235 active site 927666005236 Predicted membrane protein [Function unknown]; Region: COG2510 927666005237 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 927666005238 beta-galactosidase; Region: BGL; TIGR03356 927666005239 prolyl-tRNA synthetase; Provisional; Region: PRK09194 927666005240 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 927666005241 dimer interface [polypeptide binding]; other site 927666005242 motif 1; other site 927666005243 active site 927666005244 motif 2; other site 927666005245 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 927666005246 putative deacylase active site [active] 927666005247 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 927666005248 active site 927666005249 motif 3; other site 927666005250 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 927666005251 anticodon binding site; other site 927666005252 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 927666005253 RIP metalloprotease RseP; Region: TIGR00054 927666005254 active site 927666005255 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 927666005256 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 927666005257 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 927666005258 putative substrate binding region [chemical binding]; other site 927666005259 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 927666005260 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 927666005261 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 927666005262 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 927666005263 catalytic residue [active] 927666005264 putative FPP diphosphate binding site; other site 927666005265 putative FPP binding hydrophobic cleft; other site 927666005266 dimer interface [polypeptide binding]; other site 927666005267 putative IPP diphosphate binding site; other site 927666005268 Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042 927666005269 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 927666005270 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 927666005271 Walker A motif; other site 927666005272 ATP binding site [chemical binding]; other site 927666005273 Walker B motif; other site 927666005274 arginine finger; other site 927666005275 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 927666005276 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 927666005277 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 927666005278 Coenzyme A binding pocket [chemical binding]; other site 927666005279 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 927666005280 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 927666005281 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 927666005282 LytTr DNA-binding domain; Region: LytTR; pfam04397 927666005283 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 927666005284 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 927666005285 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 927666005286 Walker A/P-loop; other site 927666005287 ATP binding site [chemical binding]; other site 927666005288 Q-loop/lid; other site 927666005289 ABC transporter signature motif; other site 927666005290 Walker B; other site 927666005291 D-loop; other site 927666005292 H-loop/switch region; other site 927666005293 Protein of unknown function (DUF2992); Region: DUF2992; pfam11208 927666005294 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 927666005295 synthetase active site [active] 927666005296 NTP binding site [chemical binding]; other site 927666005297 metal binding site [ion binding]; metal-binding site 927666005298 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 927666005299 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 927666005300 HIGH motif; other site 927666005301 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 927666005302 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 927666005303 active site 927666005304 KMSKS motif; other site 927666005305 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 927666005306 tRNA binding surface [nucleotide binding]; other site 927666005307 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 927666005308 catalytic core [active] 927666005309 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 927666005310 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 927666005311 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 927666005312 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 927666005313 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 927666005314 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 927666005315 alphaNTD homodimer interface [polypeptide binding]; other site 927666005316 alphaNTD - beta interaction site [polypeptide binding]; other site 927666005317 alphaNTD - beta' interaction site [polypeptide binding]; other site 927666005318 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 927666005319 30S ribosomal protein S11; Validated; Region: PRK05309 927666005320 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 927666005321 30S ribosomal protein S13; Region: bact_S13; TIGR03631 927666005322 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 927666005323 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 927666005324 rRNA binding site [nucleotide binding]; other site 927666005325 predicted 30S ribosome binding site; other site 927666005326 adenylate kinase; Reviewed; Region: adk; PRK00279 927666005327 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 927666005328 AMP-binding site [chemical binding]; other site 927666005329 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 927666005330 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 927666005331 SecY translocase; Region: SecY; pfam00344 927666005332 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 927666005333 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 927666005334 23S rRNA binding site [nucleotide binding]; other site 927666005335 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 927666005336 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 927666005337 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 927666005338 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 927666005339 5S rRNA interface [nucleotide binding]; other site 927666005340 L27 interface [polypeptide binding]; other site 927666005341 23S rRNA interface [nucleotide binding]; other site 927666005342 L5 interface [polypeptide binding]; other site 927666005343 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 927666005344 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 927666005345 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 927666005346 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 927666005347 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 927666005348 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 927666005349 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 927666005350 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 927666005351 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 927666005352 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 927666005353 RNA binding site [nucleotide binding]; other site 927666005354 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 927666005355 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 927666005356 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 927666005357 23S rRNA interface [nucleotide binding]; other site 927666005358 putative translocon interaction site; other site 927666005359 signal recognition particle (SRP54) interaction site; other site 927666005360 L23 interface [polypeptide binding]; other site 927666005361 trigger factor interaction site; other site 927666005362 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 927666005363 23S rRNA interface [nucleotide binding]; other site 927666005364 5S rRNA interface [nucleotide binding]; other site 927666005365 putative antibiotic binding site [chemical binding]; other site 927666005366 L25 interface [polypeptide binding]; other site 927666005367 L27 interface [polypeptide binding]; other site 927666005368 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 927666005369 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 927666005370 G-X-X-G motif; other site 927666005371 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 927666005372 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 927666005373 putative translocon binding site; other site 927666005374 protein-rRNA interface [nucleotide binding]; other site 927666005375 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 927666005376 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 927666005377 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 927666005378 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 927666005379 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 927666005380 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 927666005381 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 927666005382 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 927666005383 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 927666005384 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 927666005385 active site 927666005386 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 927666005387 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 927666005388 FeS/SAM binding site; other site 927666005389 Predicted acetyltransferase [General function prediction only]; Region: COG3981 927666005390 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 927666005391 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 927666005392 ATP cone domain; Region: ATP-cone; pfam03477 927666005393 Class III ribonucleotide reductase; Region: RNR_III; cd01675 927666005394 effector binding site; other site 927666005395 active site 927666005396 Zn binding site [ion binding]; other site 927666005397 glycine loop; other site 927666005398 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 927666005399 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 927666005400 Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154 927666005401 putative active site [active] 927666005402 catalytic site [active] 927666005403 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 927666005404 putative active site [active] 927666005405 catalytic site [active] 927666005406 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 927666005407 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 927666005408 dimer interface [polypeptide binding]; other site 927666005409 active site 927666005410 CoA binding pocket [chemical binding]; other site 927666005411 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 927666005412 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 927666005413 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 927666005414 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 927666005415 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 927666005416 NAD(P) binding site [chemical binding]; other site 927666005417 active site 927666005418 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 927666005419 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 927666005420 active site 927666005421 TDP-binding site; other site 927666005422 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 927666005423 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 927666005424 dimer interface [polypeptide binding]; other site 927666005425 active site 927666005426 metal binding site [ion binding]; metal-binding site 927666005427 Bacterial lipoprotein; Region: DUF3642; pfam12182 927666005428 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 927666005429 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 927666005430 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 927666005431 hypothetical protein; Provisional; Region: PRK13678 927666005432 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 927666005433 hypothetical protein; Provisional; Region: PRK05473 927666005434 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 927666005435 ArsC family; Region: ArsC; pfam03960 927666005436 putative catalytic residues [active] 927666005437 thiol/disulfide switch; other site 927666005438 magnesium-transporting ATPase; Provisional; Region: PRK15122 927666005439 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 927666005440 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 927666005441 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 927666005442 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 927666005443 Soluble P-type ATPase [General function prediction only]; Region: COG4087 927666005444 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 927666005445 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 927666005446 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 927666005447 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 927666005448 active site 927666005449 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 927666005450 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 927666005451 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 927666005452 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 927666005453 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 927666005454 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 927666005455 Cl binding site [ion binding]; other site 927666005456 oligomer interface [polypeptide binding]; other site 927666005457 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 927666005458 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 927666005459 putative dimer interface [polypeptide binding]; other site 927666005460 catalytic triad [active] 927666005461 Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083 927666005462 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 927666005463 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 927666005464 RuvA N terminal domain; Region: RuvA_N; pfam01330 927666005465 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 927666005466 Major Facilitator Superfamily; Region: MFS_1; pfam07690 927666005467 putative substrate translocation pore; other site 927666005468 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 927666005469 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 927666005470 non-specific DNA binding site [nucleotide binding]; other site 927666005471 salt bridge; other site 927666005472 sequence-specific DNA binding site [nucleotide binding]; other site 927666005473 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 927666005474 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 927666005475 ATP binding site [chemical binding]; other site 927666005476 Mg2+ binding site [ion binding]; other site 927666005477 G-X-G motif; other site 927666005478 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 927666005479 ATP binding site [chemical binding]; other site 927666005480 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 927666005481 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 927666005482 LytTr DNA-binding domain; Region: LytTR; smart00850 927666005483 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 927666005484 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 927666005485 MutS domain I; Region: MutS_I; pfam01624 927666005486 MutS domain II; Region: MutS_II; pfam05188 927666005487 MutS domain III; Region: MutS_III; pfam05192 927666005488 MutS domain V; Region: MutS_V; pfam00488 927666005489 Walker A/P-loop; other site 927666005490 ATP binding site [chemical binding]; other site 927666005491 Q-loop/lid; other site 927666005492 ABC transporter signature motif; other site 927666005493 Walker B; other site 927666005494 D-loop; other site 927666005495 H-loop/switch region; other site 927666005496 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 927666005497 arginine repressor; Region: argR_whole; TIGR01529 927666005498 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 927666005499 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 927666005500 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 927666005501 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 927666005502 active site 927666005503 HIGH motif; other site 927666005504 KMSK motif region; other site 927666005505 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 927666005506 tRNA binding surface [nucleotide binding]; other site 927666005507 anticodon binding site; other site 927666005508 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 927666005509 flavoprotein NrdI; Provisional; Region: PRK02551 927666005510 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 927666005511 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 927666005512 active site 927666005513 phosphorylation site [posttranslational modification] 927666005514 intermolecular recognition site; other site 927666005515 dimerization interface [polypeptide binding]; other site 927666005516 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 927666005517 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 927666005518 Histidine kinase; Region: His_kinase; pfam06580 927666005519 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 927666005520 ATP binding site [chemical binding]; other site 927666005521 Mg2+ binding site [ion binding]; other site 927666005522 G-X-G motif; other site 927666005523 Protein of unknown function, DUF624; Region: DUF624; cl02369 927666005524 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823 927666005525 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 927666005526 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 927666005527 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 927666005528 Walker A/P-loop; other site 927666005529 ATP binding site [chemical binding]; other site 927666005530 Q-loop/lid; other site 927666005531 ABC transporter signature motif; other site 927666005532 Walker B; other site 927666005533 D-loop; other site 927666005534 H-loop/switch region; other site 927666005535 NIL domain; Region: NIL; pfam09383 927666005536 hypothetical protein; Provisional; Region: PRK06446 927666005537 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 927666005538 metal binding site [ion binding]; metal-binding site 927666005539 dimer interface [polypeptide binding]; other site 927666005540 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 927666005541 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 927666005542 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 927666005543 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 927666005544 substrate binding pocket [chemical binding]; other site 927666005545 membrane-bound complex binding site; other site 927666005546 hinge residues; other site 927666005547 Predicted membrane protein [Function unknown]; Region: COG4392 927666005548 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 927666005549 CAAX protease self-immunity; Region: Abi; pfam02517 927666005550 Helix-turn-helix domain; Region: HTH_19; pfam12844 927666005551 non-specific DNA binding site [nucleotide binding]; other site 927666005552 salt bridge; other site 927666005553 sequence-specific DNA binding site [nucleotide binding]; other site 927666005554 UGMP family protein; Validated; Region: PRK09604 927666005555 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 927666005556 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 927666005557 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 927666005558 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 927666005559 Coenzyme A binding pocket [chemical binding]; other site 927666005560 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 927666005561 Glycoprotease family; Region: Peptidase_M22; pfam00814 927666005562 MarR family; Region: MarR_2; pfam12802 927666005563 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 927666005564 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 927666005565 putative NADP binding site [chemical binding]; other site 927666005566 putative substrate binding site [chemical binding]; other site 927666005567 active site 927666005568 hypothetical protein; Provisional; Region: PRK13667 927666005569 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 927666005570 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 927666005571 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 927666005572 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 927666005573 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 927666005574 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 927666005575 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 927666005576 nudix motif; other site 927666005577 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 927666005578 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 927666005579 argininosuccinate lyase; Provisional; Region: PRK00855 927666005580 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 927666005581 active sites [active] 927666005582 tetramer interface [polypeptide binding]; other site 927666005583 argininosuccinate synthase; Provisional; Region: PRK13820 927666005584 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 927666005585 ANP binding site [chemical binding]; other site 927666005586 Substrate Binding Site II [chemical binding]; other site 927666005587 Substrate Binding Site I [chemical binding]; other site 927666005588 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 927666005589 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 927666005590 substrate binding pocket [chemical binding]; other site 927666005591 membrane-bound complex binding site; other site 927666005592 hinge residues; other site 927666005593 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 927666005594 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 927666005595 Walker A/P-loop; other site 927666005596 ATP binding site [chemical binding]; other site 927666005597 Q-loop/lid; other site 927666005598 ABC transporter signature motif; other site 927666005599 Walker B; other site 927666005600 D-loop; other site 927666005601 H-loop/switch region; other site 927666005602 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 927666005603 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 927666005604 bacteriocin, lactococcin 972 family; Region: lactococcin_972; TIGR01653 927666005605 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 927666005606 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 927666005607 non-specific DNA binding site [nucleotide binding]; other site 927666005608 salt bridge; other site 927666005609 sequence-specific DNA binding site [nucleotide binding]; other site 927666005610 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 927666005611 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 927666005612 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 927666005613 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 927666005614 putative L-serine binding site [chemical binding]; other site 927666005615 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 927666005616 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 927666005617 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 927666005618 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 927666005619 active site 927666005620 motif I; other site 927666005621 motif II; other site 927666005622 Protein of unknown function (DUF805); Region: DUF805; pfam05656 927666005623 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 927666005624 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 927666005625 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 927666005626 NAD(P) binding site [chemical binding]; other site 927666005627 homodimer interface [polypeptide binding]; other site 927666005628 substrate binding site [chemical binding]; other site 927666005629 active site 927666005630 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 927666005631 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 927666005632 active site 927666005633 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 927666005634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 927666005635 putative substrate translocation pore; other site 927666005636 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 927666005637 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 927666005638 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 927666005639 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 927666005640 Walker A motif; other site 927666005641 ATP binding site [chemical binding]; other site 927666005642 Walker B motif; other site 927666005643 arginine finger; other site 927666005644 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 927666005645 non-specific DNA binding site [nucleotide binding]; other site 927666005646 salt bridge; other site 927666005647 sequence-specific DNA binding site [nucleotide binding]; other site 927666005648 Replication initiation factor; Region: Rep_trans; pfam02486 927666005649 Antirestriction protein (ArdA); Region: ArdA; pfam07275 927666005650 TcpE family; Region: TcpE; pfam12648 927666005651 AAA-like domain; Region: AAA_10; pfam12846 927666005652 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 927666005653 Haemolysin-III related; Region: HlyIII; cl03831 927666005654 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 927666005655 N-acetyl-D-glucosamine binding site [chemical binding]; other site 927666005656 catalytic residue [active] 927666005657 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 927666005658 NlpC/P60 family; Region: NLPC_P60; pfam00877 927666005659 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 927666005660 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 927666005661 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 927666005662 G1 box; other site 927666005663 putative GEF interaction site [polypeptide binding]; other site 927666005664 GTP/Mg2+ binding site [chemical binding]; other site 927666005665 Switch I region; other site 927666005666 G2 box; other site 927666005667 G3 box; other site 927666005668 Switch II region; other site 927666005669 G4 box; other site 927666005670 G5 box; other site 927666005671 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 927666005672 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 927666005673 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 927666005674 23S rRNA methylase leader peptide (ErmC); Region: ErmC; pfam06308 927666005675 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 927666005676 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 927666005677 S-adenosylmethionine binding site [chemical binding]; other site 927666005678 multiple promoter invertase; Provisional; Region: mpi; PRK13413 927666005679 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 927666005680 catalytic residues [active] 927666005681 catalytic nucleophile [active] 927666005682 Presynaptic Site I dimer interface [polypeptide binding]; other site 927666005683 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 927666005684 Synaptic Flat tetramer interface [polypeptide binding]; other site 927666005685 Synaptic Site I dimer interface [polypeptide binding]; other site 927666005686 DNA binding site [nucleotide binding] 927666005687 Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796 927666005688 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 927666005689 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 927666005690 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 927666005691 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 927666005692 non-specific DNA binding site [nucleotide binding]; other site 927666005693 salt bridge; other site 927666005694 sequence-specific DNA binding site [nucleotide binding]; other site 927666005695 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 927666005696 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 927666005697 DNA binding residues [nucleotide binding] 927666005698 Helix-turn-helix domain; Region: HTH_16; pfam12645 927666005699 Excisionase from transposon Tn916; Region: Tn916-Xis; pfam09035 927666005700 DNA binding domain of tn916 integrase; Region: Integrase_DNA; pfam02920 927666005701 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 927666005702 Int/Topo IB signature motif; other site 927666005703 Predicted transcriptional regulators [Transcription]; Region: COG1695 927666005704 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 927666005705 Predicted membrane protein [Function unknown]; Region: COG4709 927666005706 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 927666005707 Domain of unknown function (DUF4299); Region: DUF4299; pfam14132 927666005708 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 927666005709 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 927666005710 active site residue [active] 927666005711 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 927666005712 Enterocin A Immunity; Region: EntA_Immun; pfam08951 927666005713 CAAX protease self-immunity; Region: Abi; pfam02517 927666005714 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 927666005715 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 927666005716 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 927666005717 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 927666005718 putative PBP binding loops; other site 927666005719 dimer interface [polypeptide binding]; other site 927666005720 ABC-ATPase subunit interface; other site 927666005721 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 927666005722 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 927666005723 dimer interface [polypeptide binding]; other site 927666005724 conserved gate region; other site 927666005725 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 927666005726 ABC-ATPase subunit interface; other site 927666005727 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 927666005728 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 927666005729 putative active site [active] 927666005730 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 927666005731 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 927666005732 nucleotide binding site [chemical binding]; other site 927666005733 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 927666005734 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 927666005735 active site 927666005736 metal binding site [ion binding]; metal-binding site 927666005737 homodimer interface [polypeptide binding]; other site 927666005738 catalytic site [active] 927666005739 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 927666005740 Uncharacterized conserved protein [Function unknown]; Region: COG3538 927666005741 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 927666005742 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 927666005743 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 927666005744 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 927666005745 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 927666005746 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 927666005747 Calx-beta domain; Region: Calx-beta; cl02522 927666005748 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 927666005749 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 927666005750 metal binding site [ion binding]; metal-binding site 927666005751 YodA lipocalin-like domain; Region: YodA; pfam09223 927666005752 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 927666005753 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 927666005754 ABC-ATPase subunit interface; other site 927666005755 dimer interface [polypeptide binding]; other site 927666005756 putative PBP binding regions; other site 927666005757 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 927666005758 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 927666005759 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 927666005760 putative DNA binding site [nucleotide binding]; other site 927666005761 Staphylococcus aureus SA0022 and related proteins, N-terminal metallophosphatase domain; Region: MPP_SA0022_N; cd07408 927666005762 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 927666005763 putative active site [active] 927666005764 putative metal binding site [ion binding]; other site 927666005765 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 927666005766 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 927666005767 DltD N-terminal region; Region: DltD_N; pfam04915 927666005768 DltD central region; Region: DltD_M; pfam04918 927666005769 DltD C-terminal region; Region: DltD_C; pfam04914 927666005770 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 927666005771 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 927666005772 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 927666005773 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 927666005774 acyl-activating enzyme (AAE) consensus motif; other site 927666005775 AMP binding site [chemical binding]; other site 927666005776 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 927666005777 amphipathic channel; other site 927666005778 Asn-Pro-Ala signature motifs; other site 927666005779 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 927666005780 glycerol kinase; Provisional; Region: glpK; PRK00047 927666005781 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 927666005782 N- and C-terminal domain interface [polypeptide binding]; other site 927666005783 active site 927666005784 MgATP binding site [chemical binding]; other site 927666005785 catalytic site [active] 927666005786 metal binding site [ion binding]; metal-binding site 927666005787 glycerol binding site [chemical binding]; other site 927666005788 homotetramer interface [polypeptide binding]; other site 927666005789 homodimer interface [polypeptide binding]; other site 927666005790 FBP binding site [chemical binding]; other site 927666005791 protein IIAGlc interface [polypeptide binding]; other site 927666005792 Mga helix-turn-helix domain; Region: Mga; pfam05043 927666005793 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 927666005794 Abi-like protein; Region: Abi_2; pfam07751 927666005795 potential frameshift: common BLAST hit: gi|337282618|ref|YP_004622089.1| ISSpo8 transposase 927666005796 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762 927666005797 Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760 927666005798 ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481 927666005799 Adenine-specific methyltransferase EcoRI; Region: EcoRI_methylase; pfam13651 927666005800 Protein of unknown function DUF262; Region: DUF262; pfam03235 927666005801 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 927666005802 active site 927666005803 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 927666005804 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 927666005805 dimerization interface [polypeptide binding]; other site 927666005806 domain crossover interface; other site 927666005807 redox-dependent activation switch; other site 927666005808 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 927666005809 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 927666005810 FMN binding site [chemical binding]; other site 927666005811 active site 927666005812 catalytic residues [active] 927666005813 substrate binding site [chemical binding]; other site 927666005814 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883 927666005815 nudix motif; other site 927666005816 nicotinamide mononucleotide transporter PnuC; Region: NMN_trans_PnuC; TIGR01528 927666005817 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 927666005818 active site 927666005819 KMSKS motif; other site 927666005820 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 927666005821 AAA domain; Region: AAA_28; pfam13521 927666005822 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 927666005823 active site 927666005824 HIGH motif; other site 927666005825 nucleotide binding site [chemical binding]; other site 927666005826 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 927666005827 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 927666005828 Walker A motif; other site 927666005829 ATP binding site [chemical binding]; other site 927666005830 Walker B motif; other site 927666005831 arginine finger; other site 927666005832 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 927666005833 Walker A motif; other site 927666005834 ATP binding site [chemical binding]; other site 927666005835 Walker B motif; other site 927666005836 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 927666005837 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; cl01850 927666005838 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 927666005839 T surface-antigen of pili; Region: FctA; pfam12892 927666005840 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 927666005841 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 927666005842 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 927666005843 streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786 927666005844 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 927666005845 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 927666005846 Walker A/P-loop; other site 927666005847 ATP binding site [chemical binding]; other site 927666005848 Q-loop/lid; other site 927666005849 ABC transporter signature motif; other site 927666005850 Walker B; other site 927666005851 D-loop; other site 927666005852 H-loop/switch region; other site 927666005853 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 927666005854 NMT1/THI5 like; Region: NMT1; pfam09084 927666005855 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 927666005856 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 927666005857 Uncharacterized conserved protein [Function unknown]; Region: COG0011 927666005858 DNA polymerase I; Provisional; Region: PRK05755 927666005859 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 927666005860 active site 927666005861 metal binding site 1 [ion binding]; metal-binding site 927666005862 putative 5' ssDNA interaction site; other site 927666005863 metal binding site 3; metal-binding site 927666005864 metal binding site 2 [ion binding]; metal-binding site 927666005865 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 927666005866 putative DNA binding site [nucleotide binding]; other site 927666005867 putative metal binding site [ion binding]; other site 927666005868 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 927666005869 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 927666005870 active site 927666005871 DNA binding site [nucleotide binding] 927666005872 catalytic site [active] 927666005873 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07003 927666005874 Surface antigen [General function prediction only]; Region: COG3942 927666005875 CHAP domain; Region: CHAP; pfam05257 927666005876 Bacterial SH3 domain; Region: SH3_5; pfam08460 927666005877 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 927666005878 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 927666005879 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 927666005880 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 927666005881 Protein of unknown function (DUF1021); Region: DUF1021; cl01852 927666005882 replicative DNA helicase; Provisional; Region: PRK05748 927666005883 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 927666005884 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 927666005885 Walker A motif; other site 927666005886 ATP binding site [chemical binding]; other site 927666005887 Walker B motif; other site 927666005888 DNA binding loops [nucleotide binding] 927666005889 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 927666005890 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 927666005891 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 927666005892 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 927666005893 DHH family; Region: DHH; pfam01368 927666005894 DHHA1 domain; Region: DHHA1; pfam02272 927666005895 putative acyltransferase; Provisional; Region: PRK05790 927666005896 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 927666005897 dimer interface [polypeptide binding]; other site 927666005898 active site 927666005899 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 927666005900 30S subunit binding site; other site 927666005901 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 927666005902 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 927666005903 active site 927666005904 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 927666005905 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 927666005906 ATP binding site [chemical binding]; other site 927666005907 putative Mg++ binding site [ion binding]; other site 927666005908 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 927666005909 nucleotide binding region [chemical binding]; other site 927666005910 ATP-binding site [chemical binding]; other site 927666005911 Uncharacterized conserved protein [Function unknown]; Region: COG1739 927666005912 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 927666005913 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 927666005914 Pleckstrin homology-like domain; Region: PH-like; cl17171 927666005915 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 927666005916 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 927666005917 dimer interface [polypeptide binding]; other site 927666005918 pyridoxal 5'-phosphate binding site [chemical binding]; other site 927666005919 catalytic residue [active] 927666005920 elongation factor Ts; Provisional; Region: tsf; PRK09377 927666005921 UBA/TS-N domain; Region: UBA; pfam00627 927666005922 Elongation factor TS; Region: EF_TS; pfam00889 927666005923 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 927666005924 rRNA interaction site [nucleotide binding]; other site 927666005925 S8 interaction site; other site 927666005926 putative laminin-1 binding site; other site 927666005927 Transposase; Region: HTH_Tnp_IS630; pfam01710 927666005928 Helix-turn-helix domain; Region: HTH_28; pfam13518 927666005929 DDE superfamily endonuclease; Region: DDE_3; pfam13358 927666005930 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 927666005931 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 927666005932 Helix-turn-helix domain; Region: HTH_38; pfam13936 927666005933 DNA-binding interface [nucleotide binding]; DNA binding site 927666005934 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 927666005935 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 927666005936 Integrase core domain; Region: rve; pfam00665 927666005937 Surface antigen [General function prediction only]; Region: COG3942 927666005938 CHAP domain; Region: CHAP; pfam05257 927666005939 Bacterial SH3 domain; Region: SH3_5; pfam08460 927666005940 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 927666005941 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 927666005942 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 927666005943 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 927666005944 FemAB family; Region: FemAB; pfam02388 927666005945 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 927666005946 Septum formation initiator; Region: DivIC; cl17659 927666005947 Surface antigen [General function prediction only]; Region: COG3942 927666005948 CHAP domain; Region: CHAP; pfam05257 927666005949 rod shape-determining protein MreD; Region: MreD; cl01087 927666005950 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 927666005951 Regulator of replication initiation timing [Replication, recombination, and repair]; Region: COG4467; cl01853 927666005952 rod shape-determining protein MreC; Region: MreC; pfam04085 927666005953 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 927666005954 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13649 927666005955 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 927666005956 Walker A/P-loop; other site 927666005957 ATP binding site [chemical binding]; other site 927666005958 Q-loop/lid; other site 927666005959 ABC transporter signature motif; other site 927666005960 Walker B; other site 927666005961 D-loop; other site 927666005962 H-loop/switch region; other site 927666005963 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13650 927666005964 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 927666005965 Walker A/P-loop; other site 927666005966 ATP binding site [chemical binding]; other site 927666005967 Q-loop/lid; other site 927666005968 ABC transporter signature motif; other site 927666005969 Walker B; other site 927666005970 D-loop; other site 927666005971 H-loop/switch region; other site 927666005972 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 927666005973 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 927666005974 Helix-turn-helix domain; Region: HTH_25; pfam13413 927666005975 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 927666005976 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 927666005977 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 927666005978 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 927666005979 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 927666005980 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 927666005981 RNA binding surface [nucleotide binding]; other site 927666005982 recombination protein F; Reviewed; Region: recF; PRK00064 927666005983 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 927666005984 Walker A/P-loop; other site 927666005985 ATP binding site [chemical binding]; other site 927666005986 Q-loop/lid; other site 927666005987 ABC transporter signature motif; other site 927666005988 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 927666005989 ABC transporter signature motif; other site 927666005990 Walker B; other site 927666005991 D-loop; other site 927666005992 H-loop/switch region; other site 927666005993 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 927666005994 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 927666005995 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 927666005996 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 927666005997 active site 927666005998 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 927666005999 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 927666006000 active site 927666006001 HIGH motif; other site 927666006002 dimer interface [polypeptide binding]; other site 927666006003 KMSKS motif; other site 927666006004 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 927666006005 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 927666006006 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 927666006007 ABC transporter; Region: ABC_tran_2; pfam12848 927666006008 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 927666006009 Predicted membrane protein [Function unknown]; Region: COG4485 927666006010 Predicted membrane protein [Function unknown]; Region: COG1511 927666006011 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 927666006012 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 927666006013 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 927666006014 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 927666006015 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 927666006016 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 927666006017 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 927666006018 active site 927666006019 phosphorylation site [posttranslational modification] 927666006020 intermolecular recognition site; other site 927666006021 dimerization interface [polypeptide binding]; other site 927666006022 LytTr DNA-binding domain; Region: LytTR; pfam04397 927666006023 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 927666006024 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 927666006025 COMC family; Region: ComC; pfam03047 927666006026 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 927666006027 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 927666006028 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 927666006029 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 927666006030 protein binding site [polypeptide binding]; other site 927666006031 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 927666006032 ParB-like nuclease domain; Region: ParBc; pfam02195 927666006033 KorB domain; Region: KorB; pfam08535