-- dump date   	20140620_083724
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1114965000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
1114965000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1114965000003	Walker A motif; other site
1114965000004	ATP binding site [chemical binding]; other site
1114965000005	Walker B motif; other site
1114965000006	arginine finger; other site
1114965000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1114965000008	DnaA box-binding interface [nucleotide binding]; other site
1114965000009	DNA polymerase III subunit beta; Validated; Region: PRK05643
1114965000010	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1114965000011	putative DNA binding surface [nucleotide binding]; other site
1114965000012	dimer interface [polypeptide binding]; other site
1114965000013	beta-clamp/clamp loader binding surface; other site
1114965000014	beta-clamp/translesion DNA polymerase binding surface; other site
1114965000015	Protein of unknown function (DUF1307); Region: DUF1307; cl01981
1114965000016	GTP-binding protein YchF; Reviewed; Region: PRK09601
1114965000017	YchF GTPase; Region: YchF; cd01900
1114965000018	G1 box; other site
1114965000019	GTP/Mg2+ binding site [chemical binding]; other site
1114965000020	Switch I region; other site
1114965000021	G2 box; other site
1114965000022	Switch II region; other site
1114965000023	G3 box; other site
1114965000024	G4 box; other site
1114965000025	G5 box; other site
1114965000026	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1114965000027	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1114965000028	putative active site [active]
1114965000029	catalytic residue [active]
1114965000030	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
1114965000031	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
1114965000032	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1114965000033	ATP binding site [chemical binding]; other site
1114965000034	putative Mg++ binding site [ion binding]; other site
1114965000035	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1114965000036	nucleotide binding region [chemical binding]; other site
1114965000037	ATP-binding site [chemical binding]; other site
1114965000038	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
1114965000039	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1114965000040	RNA binding surface [nucleotide binding]; other site
1114965000041	Septum formation initiator; Region: DivIC; cl17659
1114965000042	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
1114965000043	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
1114965000044	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
1114965000045	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
1114965000046	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1114965000047	Ligand Binding Site [chemical binding]; other site
1114965000048	TilS substrate C-terminal domain; Region: TilS_C; smart00977
1114965000049	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
1114965000050	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1114965000051	active site
1114965000052	FtsH Extracellular; Region: FtsH_ext; pfam06480
1114965000053	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
1114965000054	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1114965000055	Walker A motif; other site
1114965000056	ATP binding site [chemical binding]; other site
1114965000057	Walker B motif; other site
1114965000058	arginine finger; other site
1114965000059	Peptidase family M41; Region: Peptidase_M41; pfam01434
1114965000060	Helix-turn-helix domain; Region: HTH_38; pfam13936
1114965000061	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1114965000062	Integrase core domain; Region: rve; pfam00665
1114965000063	rod shape-determining protein MreC; Provisional; Region: PRK13922
1114965000064	rod shape-determining protein MreC; Region: MreC; pfam04085
1114965000065	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
1114965000066	Septum formation initiator; Region: DivIC; cl17659
1114965000067	Surface antigen [General function prediction only]; Region: COG3942
1114965000068	CHAP domain; Region: CHAP; pfam05257
1114965000069	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1114965000070	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1114965000071	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1114965000072	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269
1114965000073	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1114965000074	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1114965000075	active site
1114965000076	Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826
1114965000077	active site
1114965000078	catalytic site [active]
1114965000079	aromatic amino acid aminotransferase; Validated; Region: PRK07309
1114965000080	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1114965000081	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1114965000082	homodimer interface [polypeptide binding]; other site
1114965000083	catalytic residue [active]
1114965000084	Recombination protein O N terminal; Region: RecO_N; pfam11967
1114965000085	DNA repair protein RecO; Region: reco; TIGR00613
1114965000086	Recombination protein O C terminal; Region: RecO_C; pfam02565
1114965000087	putative phosphate acyltransferase; Provisional; Region: PRK05331
1114965000088	Phosphopantetheine attachment site; Region: PP-binding; cl09936
1114965000089	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
1114965000090	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
1114965000091	ATP binding site [chemical binding]; other site
1114965000092	active site
1114965000093	substrate binding site [chemical binding]; other site
1114965000094	phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857
1114965000095	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
1114965000096	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
1114965000097	dimerization interface [polypeptide binding]; other site
1114965000098	ATP binding site [chemical binding]; other site
1114965000099	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
1114965000100	dimerization interface [polypeptide binding]; other site
1114965000101	ATP binding site [chemical binding]; other site
1114965000102	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
1114965000103	putative active site [active]
1114965000104	catalytic triad [active]
1114965000105	amidophosphoribosyltransferase; Provisional; Region: PRK07272
1114965000106	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
1114965000107	active site
1114965000108	tetramer interface [polypeptide binding]; other site
1114965000109	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1114965000110	active site
1114965000111	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
1114965000112	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
1114965000113	dimerization interface [polypeptide binding]; other site
1114965000114	putative ATP binding site [chemical binding]; other site
1114965000115	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
1114965000116	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
1114965000117	active site
1114965000118	substrate binding site [chemical binding]; other site
1114965000119	cosubstrate binding site; other site
1114965000120	catalytic site [active]
1114965000121	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
1114965000122	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
1114965000123	purine monophosphate binding site [chemical binding]; other site
1114965000124	dimer interface [polypeptide binding]; other site
1114965000125	putative catalytic residues [active]
1114965000126	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
1114965000127	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
1114965000128	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
1114965000129	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
1114965000130	CHAP domain; Region: CHAP; pfam05257
1114965000131	Surface antigen [General function prediction only]; Region: COG3942
1114965000132	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
1114965000133	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
1114965000134	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
1114965000135	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
1114965000136	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
1114965000137	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
1114965000138	ATP-grasp domain; Region: ATP-grasp; pfam02222
1114965000139	Ketopantoate reductase [Coenzyme metabolism]; Region: ApbA; COG1893
1114965000140	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
1114965000141	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1114965000142	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1114965000143	active site
1114965000144	ATP binding site [chemical binding]; other site
1114965000145	substrate binding site [chemical binding]; other site
1114965000146	activation loop (A-loop); other site
1114965000147	adenylosuccinate lyase; Provisional; Region: PRK07492
1114965000148	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
1114965000149	tetramer interface [polypeptide binding]; other site
1114965000150	active site
1114965000151	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1114965000152	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1114965000153	DNA-binding site [nucleotide binding]; DNA binding site
1114965000154	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1114965000155	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
1114965000156	Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301
1114965000157	Beta-galactosidase jelly roll domain; Region: BetaGal_dom4_5; pfam13364
1114965000158	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
1114965000159	active site
1114965000160	phosphorylation site [posttranslational modification]
1114965000161	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
1114965000162	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
1114965000163	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1114965000164	active pocket/dimerization site; other site
1114965000165	active site
1114965000166	phosphorylation site [posttranslational modification]
1114965000167	putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815
1114965000168	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1114965000169	dimer interface [polypeptide binding]; other site
1114965000170	active site
1114965000171	AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010
1114965000172	putative active site [active]
1114965000173	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
1114965000174	active site
1114965000175	catalytic residues [active]
1114965000176	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1114965000177	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1114965000178	Walker A motif; other site
1114965000179	ATP binding site [chemical binding]; other site
1114965000180	Walker B motif; other site
1114965000181	arginine finger; other site
1114965000182	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1114965000183	Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042
1114965000184	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1114965000185	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1114965000186	active site
1114965000187	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
1114965000188	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
1114965000189	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
1114965000190	active site
1114965000191	catalytic triad [active]
1114965000192	oxyanion hole [active]
1114965000193	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
1114965000194	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
1114965000195	putative catalytic cysteine [active]
1114965000196	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
1114965000197	putative active site [active]
1114965000198	metal binding site [ion binding]; metal-binding site
1114965000199	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK06278
1114965000200	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286
1114965000201	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1114965000202	catalytic Zn binding site [ion binding]; other site
1114965000203	structural Zn binding site [ion binding]; other site
1114965000204	NAD(P) binding site [chemical binding]; other site
1114965000205	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
1114965000206	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
1114965000207	putative active site cavity [active]
1114965000208	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1114965000209	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1114965000210	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1114965000211	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1114965000212	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1114965000213	dimer interface [polypeptide binding]; other site
1114965000214	ABC-ATPase subunit interface; other site
1114965000215	putative PBP binding loops; other site
1114965000216	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1114965000217	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1114965000218	dimer interface [polypeptide binding]; other site
1114965000219	conserved gate region; other site
1114965000220	putative PBP binding loops; other site
1114965000221	ABC-ATPase subunit interface; other site
1114965000222	Domain of unknown function (DUF386); Region: DUF386; pfam04074
1114965000223	Protein of unknown function, DUF624; Region: DUF624; pfam04854
1114965000224	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1114965000225	Class I aldolases; Region: Aldolase_Class_I; cl17187
1114965000226	catalytic residue [active]
1114965000227	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1114965000228	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1114965000229	nucleotide binding site [chemical binding]; other site
1114965000230	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1114965000231	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1114965000232	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1114965000233	putative active site [active]
1114965000234	V-type ATP synthase subunit I; Validated; Region: PRK05771
1114965000235	V-type ATP synthase subunit K; Validated; Region: PRK08344
1114965000236	ATP synthase subunit C; Region: ATP-synt_C; pfam00137
1114965000237	ATP synthase subunit C; Region: ATP-synt_C; pfam00137
1114965000238	ribonuclease Y; Region: RNase_Y; TIGR03319
1114965000239	V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660
1114965000240	Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527
1114965000241	V-type ATP synthase subunit F; Provisional; Region: PRK01395
1114965000242	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1114965000243	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1114965000244	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1114965000245	V-type ATP synthase subunit A; Provisional; Region: PRK04192
1114965000246	V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction.  The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134
1114965000247	Walker A motif/ATP binding site; other site
1114965000248	Walker B motif; other site
1114965000249	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1114965000250	V-type ATP synthase subunit B; Provisional; Region: PRK04196
1114965000251	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1114965000252	V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135
1114965000253	Walker A motif homologous position; other site
1114965000254	Walker B motif; other site
1114965000255	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1114965000256	V-type ATP synthase subunit D; Reviewed; Region: PRK00373
1114965000257	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1114965000258	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
1114965000259	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1114965000260	putative substrate translocation pore; other site
1114965000261	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1114965000262	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1114965000263	non-specific DNA binding site [nucleotide binding]; other site
1114965000264	salt bridge; other site
1114965000265	sequence-specific DNA binding site [nucleotide binding]; other site
1114965000266	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1114965000267	dimerization interface [polypeptide binding]; other site
1114965000268	putative DNA binding site [nucleotide binding]; other site
1114965000269	putative Zn2+ binding site [ion binding]; other site
1114965000270	Predicted integral membrane protein [Function unknown]; Region: COG5658
1114965000271	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
1114965000272	SdpI/YhfL protein family; Region: SdpI; pfam13630
1114965000273	Rib/alpha/Esp surface antigen repeat; Region: rib_alpha; TIGR02331
1114965000274	Rib/alpha/Esp surface antigen repeat; Region: rib_alpha; TIGR02331
1114965000275	Rib/alpha/Esp surface antigen repeat; Region: rib_alpha; TIGR02331
1114965000276	Rib/alpha/Esp surface antigen repeat; Region: rib_alpha; TIGR02331
1114965000277	Rib/alpha/Esp surface antigen repeat; Region: rib_alpha; TIGR02331
1114965000278	Rib/alpha/Esp surface antigen repeat; Region: rib_alpha; TIGR02331
1114965000279	Rib/alpha-like repeat; Region: Rib; pfam08428
1114965000280	Rib/alpha/Esp surface antigen repeat; Region: rib_alpha; TIGR02331
1114965000281	Rib/alpha-like repeat; Region: Rib; pfam08428
1114965000282	Rib/alpha-like repeat; Region: Rib; pfam08428
1114965000283	Rib/alpha-like repeat; Region: Rib; pfam08428
1114965000284	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
1114965000285	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
1114965000286	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
1114965000287	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877
1114965000288	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1114965000289	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_2; cd03402
1114965000290	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
1114965000291	6-phosphogluconate dehydratase; Region: edd; TIGR01196
1114965000292	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1114965000293	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1114965000294	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1114965000295	uracil transporter; Provisional; Region: PRK10720
1114965000296	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
1114965000297	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
1114965000298	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1114965000299	dimer interface [polypeptide binding]; other site
1114965000300	motif 1; other site
1114965000301	active site
1114965000302	motif 2; other site
1114965000303	motif 3; other site
1114965000304	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
1114965000305	anticodon binding site; other site
1114965000306	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
1114965000307	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
1114965000308	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1114965000309	catalytic residue [active]
1114965000310	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1114965000311	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
1114965000312	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
1114965000313	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1114965000314	motif II; other site
1114965000315	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1114965000316	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1114965000317	putative DNA binding site [nucleotide binding]; other site
1114965000318	putative Zn2+ binding site [ion binding]; other site
1114965000319	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
1114965000320	anthranilate synthase component I; Provisional; Region: PRK13570
1114965000321	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1114965000322	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1114965000323	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1114965000324	Glutamine amidotransferase class-I; Region: GATase; pfam00117
1114965000325	glutamine binding [chemical binding]; other site
1114965000326	catalytic triad [active]
1114965000327	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
1114965000328	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1114965000329	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1114965000330	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1114965000331	active site
1114965000332	ribulose/triose binding site [chemical binding]; other site
1114965000333	phosphate binding site [ion binding]; other site
1114965000334	substrate (anthranilate) binding pocket [chemical binding]; other site
1114965000335	product (indole) binding pocket [chemical binding]; other site
1114965000336	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
1114965000337	active site
1114965000338	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
1114965000339	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
1114965000340	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1114965000341	catalytic residue [active]
1114965000342	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
1114965000343	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
1114965000344	substrate binding site [chemical binding]; other site
1114965000345	active site
1114965000346	catalytic residues [active]
1114965000347	heterodimer interface [polypeptide binding]; other site
1114965000348	Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812
1114965000349	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
1114965000350	DNA polymerase I; Provisional; Region: PRK05755
1114965000351	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1114965000352	active site
1114965000353	metal binding site 1 [ion binding]; metal-binding site
1114965000354	putative 5' ssDNA interaction site; other site
1114965000355	metal binding site 3; metal-binding site
1114965000356	metal binding site 2 [ion binding]; metal-binding site
1114965000357	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1114965000358	putative DNA binding site [nucleotide binding]; other site
1114965000359	putative metal binding site [ion binding]; other site
1114965000360	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
1114965000361	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
1114965000362	active site
1114965000363	DNA binding site [nucleotide binding]
1114965000364	catalytic site [active]
1114965000365	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
1114965000366	Protein of unknown function (DUF975); Region: DUF975; cl10504
1114965000367	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
1114965000368	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
1114965000369	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
1114965000370	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
1114965000371	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
1114965000372	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
1114965000373	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1114965000374	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1114965000375	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1114965000376	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
1114965000377	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
1114965000378	putative translocon binding site; other site
1114965000379	protein-rRNA interface [nucleotide binding]; other site
1114965000380	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1114965000381	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
1114965000382	G-X-X-G motif; other site
1114965000383	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1114965000384	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
1114965000385	23S rRNA interface [nucleotide binding]; other site
1114965000386	5S rRNA interface [nucleotide binding]; other site
1114965000387	putative antibiotic binding site [chemical binding]; other site
1114965000388	L25 interface [polypeptide binding]; other site
1114965000389	L27 interface [polypeptide binding]; other site
1114965000390	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
1114965000391	23S rRNA interface [nucleotide binding]; other site
1114965000392	putative translocon interaction site; other site
1114965000393	signal recognition particle (SRP54) interaction site; other site
1114965000394	L23 interface [polypeptide binding]; other site
1114965000395	trigger factor interaction site; other site
1114965000396	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
1114965000397	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
1114965000398	KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354
1114965000399	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
1114965000400	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
1114965000401	RNA binding site [nucleotide binding]; other site
1114965000402	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1114965000403	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
1114965000404	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1114965000405	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
1114965000406	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
1114965000407	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1114965000408	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1114965000409	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1114965000410	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
1114965000411	5S rRNA interface [nucleotide binding]; other site
1114965000412	L27 interface [polypeptide binding]; other site
1114965000413	23S rRNA interface [nucleotide binding]; other site
1114965000414	L5 interface [polypeptide binding]; other site
1114965000415	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
1114965000416	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1114965000417	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1114965000418	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
1114965000419	23S rRNA binding site [nucleotide binding]; other site
1114965000420	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
1114965000421	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
1114965000422	SecY translocase; Region: SecY; pfam00344
1114965000423	adenylate kinase; Reviewed; Region: adk; PRK00279
1114965000424	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1114965000425	AMP-binding site [chemical binding]; other site
1114965000426	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1114965000427	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1114965000428	rRNA binding site [nucleotide binding]; other site
1114965000429	predicted 30S ribosome binding site; other site
1114965000430	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
1114965000431	30S ribosomal protein S13; Region: bact_S13; TIGR03631
1114965000432	30S ribosomal protein S11; Validated; Region: PRK05309
1114965000433	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1114965000434	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1114965000435	alphaNTD homodimer interface [polypeptide binding]; other site
1114965000436	alphaNTD - beta interaction site [polypeptide binding]; other site
1114965000437	alphaNTD - beta' interaction site [polypeptide binding]; other site
1114965000438	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1114965000439	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
1114965000440	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
1114965000441	HTH-like domain; Region: HTH_21; pfam13276
1114965000442	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
1114965000443	Integrase core domain; Region: rve; pfam00665
1114965000444	Integrase core domain; Region: rve_2; pfam13333
1114965000445	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1114965000446	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1114965000447	dimerization interface [polypeptide binding]; other site
1114965000448	putative Zn2+ binding site [ion binding]; other site
1114965000449	putative DNA binding site [nucleotide binding]; other site
1114965000450	Transposase; Region: HTH_Tnp_1; cl17663
1114965000451	aspartate kinase; Reviewed; Region: PRK09034
1114965000452	AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245
1114965000453	putative catalytic residues [active]
1114965000454	putative nucleotide binding site [chemical binding]; other site
1114965000455	putative aspartate binding site [chemical binding]; other site
1114965000456	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
1114965000457	allosteric regulatory residue; other site
1114965000458	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
1114965000459	enoyl-CoA hydratase; Provisional; Region: PRK07260
1114965000460	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1114965000461	substrate binding site [chemical binding]; other site
1114965000462	oxyanion hole (OAH) forming residues; other site
1114965000463	trimer interface [polypeptide binding]; other site
1114965000464	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1114965000465	MarR family; Region: MarR_2; pfam12802
1114965000466	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
1114965000467	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1114965000468	dimer interface [polypeptide binding]; other site
1114965000469	active site
1114965000470	CoA binding pocket [chemical binding]; other site
1114965000471	acyl carrier protein; Provisional; Region: acpP; PRK00982
1114965000472	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
1114965000473	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1114965000474	FMN binding site [chemical binding]; other site
1114965000475	substrate binding site [chemical binding]; other site
1114965000476	putative catalytic residue [active]
1114965000477	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1114965000478	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1114965000479	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1114965000480	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1114965000481	NAD(P) binding site [chemical binding]; other site
1114965000482	active site
1114965000483	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
1114965000484	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1114965000485	dimer interface [polypeptide binding]; other site
1114965000486	active site
1114965000487	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
1114965000488	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1114965000489	carboxyltransferase (CT) interaction site; other site
1114965000490	biotinylation site [posttranslational modification]; other site
1114965000491	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1114965000492	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1114965000493	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1114965000494	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1114965000495	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1114965000496	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
1114965000497	Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571
1114965000498	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1114965000499	acetyl-CoA carboxylase subunit alpha; Provisional; Region: PRK12319
1114965000500	seryl-tRNA synthetase; Provisional; Region: PRK05431
1114965000501	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1114965000502	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1114965000503	dimer interface [polypeptide binding]; other site
1114965000504	active site
1114965000505	motif 1; other site
1114965000506	motif 2; other site
1114965000507	motif 3; other site
1114965000508	Domain of unknown function (DUF956); Region: DUF956; pfam06115
1114965000509	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
1114965000510	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
1114965000511	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
1114965000512	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
1114965000513	active pocket/dimerization site; other site
1114965000514	active site
1114965000515	phosphorylation site [posttranslational modification]
1114965000516	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
1114965000517	active site
1114965000518	phosphorylation site [posttranslational modification]
1114965000519	ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422
1114965000520	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
1114965000521	NAD binding site [chemical binding]; other site
1114965000522	substrate binding site [chemical binding]; other site
1114965000523	catalytic Zn binding site [ion binding]; other site
1114965000524	tetramer interface [polypeptide binding]; other site
1114965000525	structural Zn binding site [ion binding]; other site
1114965000526	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1114965000527	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1114965000528	active site
1114965000529	motif I; other site
1114965000530	motif II; other site
1114965000531	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1114965000532	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
1114965000533	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1114965000534	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
1114965000535	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1114965000536	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1114965000537	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1114965000538	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
1114965000539	HIT family signature motif; other site
1114965000540	catalytic residue [active]
1114965000541	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1114965000542	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1114965000543	Walker A/P-loop; other site
1114965000544	ATP binding site [chemical binding]; other site
1114965000545	Q-loop/lid; other site
1114965000546	ABC transporter signature motif; other site
1114965000547	Walker B; other site
1114965000548	D-loop; other site
1114965000549	H-loop/switch region; other site
1114965000550	Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542
1114965000551	Thiamine kinase and related kinases [Coenzyme transport and metabolism]; Region: ycfN; COG0510
1114965000552	Phosphotransferase enzyme family; Region: APH; pfam01636
1114965000553	active site
1114965000554	ATP binding site [chemical binding]; other site
1114965000555	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1114965000556	S-adenosylmethionine binding site [chemical binding]; other site
1114965000557	ribosome maturation protein RimP; Reviewed; Region: PRK00092
1114965000558	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
1114965000559	putative oligomer interface [polypeptide binding]; other site
1114965000560	putative RNA binding site [nucleotide binding]; other site
1114965000561	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
1114965000562	NusA N-terminal domain; Region: NusA_N; pfam08529
1114965000563	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1114965000564	RNA binding site [nucleotide binding]; other site
1114965000565	homodimer interface [polypeptide binding]; other site
1114965000566	NusA-like KH domain; Region: KH_5; pfam13184
1114965000567	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1114965000568	G-X-X-G motif; other site
1114965000569	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
1114965000570	putative RNA binding cleft [nucleotide binding]; other site
1114965000571	hypothetical protein; Provisional; Region: PRK07283
1114965000572	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1114965000573	translation initiation factor IF-2; Region: IF-2; TIGR00487
1114965000574	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1114965000575	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1114965000576	G1 box; other site
1114965000577	putative GEF interaction site [polypeptide binding]; other site
1114965000578	GTP/Mg2+ binding site [chemical binding]; other site
1114965000579	Switch I region; other site
1114965000580	G2 box; other site
1114965000581	G3 box; other site
1114965000582	Switch II region; other site
1114965000583	G4 box; other site
1114965000584	G5 box; other site
1114965000585	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1114965000586	Translation-initiation factor 2; Region: IF-2; pfam11987
1114965000587	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1114965000588	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
1114965000589	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
1114965000590	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
1114965000591	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
1114965000592	PhoU domain; Region: PhoU; pfam01895
1114965000593	PhoU domain; Region: PhoU; pfam01895
1114965000594	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
1114965000595	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
1114965000596	active site
1114965000597	dimer interface [polypeptide binding]; other site
1114965000598	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1114965000599	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1114965000600	active site
1114965000601	catalytic tetrad [active]
1114965000602	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
1114965000603	putative active site [active]
1114965000604	catalytic triad [active]
1114965000605	PA_C5a_like: Protease-associated domain containing proteins like Streptococcus pyogenes C5a peptidase. This group contains various PA domain-containing proteins similar to S. pyogenes C5a, including, i) Vpr, a minor extracellular serine protease from...; Region: PA_C5a_like; cd02133
1114965000606	PA/protease domain interface [polypeptide binding]; other site
1114965000607	putative integrin binding motif; other site
1114965000608	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
1114965000609	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
1114965000610	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
1114965000611	dimer interface [polypeptide binding]; other site
1114965000612	motif 1; other site
1114965000613	active site
1114965000614	motif 2; other site
1114965000615	motif 3; other site
1114965000616	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
1114965000617	hypothetical protein; Provisional; Region: PRK02539
1114965000618	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
1114965000619	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
1114965000620	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
1114965000621	MraW methylase family; Region: Methyltransf_5; pfam01795
1114965000622	Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839
1114965000623	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1114965000624	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1114965000625	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1114965000626	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
1114965000627	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
1114965000628	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
1114965000629	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1114965000630	Mg++ binding site [ion binding]; other site
1114965000631	putative catalytic motif [active]
1114965000632	putative substrate binding site [chemical binding]; other site
1114965000633	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1114965000634	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1114965000635	ATP binding site [chemical binding]; other site
1114965000636	Mg++ binding site [ion binding]; other site
1114965000637	motif III; other site
1114965000638	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1114965000639	nucleotide binding region [chemical binding]; other site
1114965000640	ATP-binding site [chemical binding]; other site
1114965000641	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1114965000642	dimer interface [polypeptide binding]; other site
1114965000643	conserved gate region; other site
1114965000644	putative PBP binding loops; other site
1114965000645	ABC-ATPase subunit interface; other site
1114965000646	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1114965000647	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1114965000648	Walker A/P-loop; other site
1114965000649	ATP binding site [chemical binding]; other site
1114965000650	Q-loop/lid; other site
1114965000651	ABC transporter signature motif; other site
1114965000652	Walker B; other site
1114965000653	D-loop; other site
1114965000654	H-loop/switch region; other site
1114965000655	Protein of unknown function (DUF4059); Region: DUF4059; pfam13268
1114965000656	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
1114965000657	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1114965000658	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1114965000659	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
1114965000660	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
1114965000661	active site
1114965000662	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
1114965000663	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1114965000664	homodimer interface [polypeptide binding]; other site
1114965000665	NAD binding pocket [chemical binding]; other site
1114965000666	ATP binding pocket [chemical binding]; other site
1114965000667	Mg binding site [ion binding]; other site
1114965000668	active-site loop [active]
1114965000669	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1114965000670	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1114965000671	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
1114965000672	trimer interface [polypeptide binding]; other site
1114965000673	active site
1114965000674	G bulge; other site
1114965000675	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
1114965000676	Helix-turn-helix domain; Region: HTH_38; pfam13936
1114965000677	Integrase core domain; Region: rve; pfam00665
1114965000678	Transglycosylase; Region: Transgly; pfam00912
1114965000679	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1114965000680	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1114965000681	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
1114965000682	hypothetical protein; Provisional; Region: PRK13660
1114965000683	cell division protein GpsB; Provisional; Region: PRK14127
1114965000684	DivIVA domain; Region: DivI1A_domain; TIGR03544
1114965000685	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
1114965000686	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
1114965000687	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1114965000688	S-ribosylhomocysteinase; Provisional; Region: PRK02260
1114965000689	hypothetical protein; Provisional; Region: PRK00106
1114965000690	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1114965000691	Zn2+ binding site [ion binding]; other site
1114965000692	Mg2+ binding site [ion binding]; other site
1114965000693	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
1114965000694	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1114965000695	catalytic site [active]
1114965000696	G-X2-G-X-G-K; other site
1114965000697	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
1114965000698	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
1114965000699	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1114965000700	ATP binding site [chemical binding]; other site
1114965000701	putative Mg++ binding site [ion binding]; other site
1114965000702	Dof domain, zinc finger; Region: zf-Dof; pfam02701
1114965000703	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1114965000704	nucleotide binding region [chemical binding]; other site
1114965000705	ATP-binding site [chemical binding]; other site
1114965000706	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1114965000707	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1114965000708	putative active site [active]
1114965000709	substrate binding site [chemical binding]; other site
1114965000710	putative cosubstrate binding site; other site
1114965000711	catalytic site [active]
1114965000712	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1114965000713	substrate binding site [chemical binding]; other site
1114965000714	16S rRNA methyltransferase B; Provisional; Region: PRK14902
1114965000715	NusB family; Region: NusB; pfam01029
1114965000716	putative RNA binding site [nucleotide binding]; other site
1114965000717	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
1114965000718	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
1114965000719	active site
1114965000720	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
1114965000721	Catalytic domain of Protein Kinases; Region: PKc; cd00180
1114965000722	active site
1114965000723	ATP binding site [chemical binding]; other site
1114965000724	substrate binding site [chemical binding]; other site
1114965000725	activation loop (A-loop); other site
1114965000726	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1114965000727	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1114965000728	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
1114965000729	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
1114965000730	Predicted membrane protein [Function unknown]; Region: COG4758
1114965000731	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
1114965000732	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1114965000733	Histidine kinase; Region: HisKA_3; pfam07730
1114965000734	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1114965000735	ATP binding site [chemical binding]; other site
1114965000736	Mg2+ binding site [ion binding]; other site
1114965000737	G-X-G motif; other site
1114965000738	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1114965000739	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1114965000740	active site
1114965000741	phosphorylation site [posttranslational modification]
1114965000742	intermolecular recognition site; other site
1114965000743	dimerization interface [polypeptide binding]; other site
1114965000744	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1114965000745	DNA binding residues [nucleotide binding]
1114965000746	dimerization interface [polypeptide binding]; other site
1114965000747	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1114965000748	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1114965000749	active site
1114965000750	motif I; other site
1114965000751	motif II; other site
1114965000752	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1114965000753	Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652
1114965000754	active site
1114965000755	Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098
1114965000756	hypothetical protein; Provisional; Region: PRK07252
1114965000757	RNA binding site [nucleotide binding]; other site
1114965000758	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1114965000759	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1114965000760	dimer interface [polypeptide binding]; other site
1114965000761	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1114965000762	catalytic residue [active]
1114965000763	Uncharacterized conserved protein [Function unknown]; Region: COG1739
1114965000764	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
1114965000765	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
1114965000766	Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098
1114965000767	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1114965000768	ATP binding site [chemical binding]; other site
1114965000769	putative Mg++ binding site [ion binding]; other site
1114965000770	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1114965000771	nucleotide binding region [chemical binding]; other site
1114965000772	ATP-binding site [chemical binding]; other site
1114965000773	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
1114965000774	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1114965000775	active site
1114965000776	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1114965000777	30S subunit binding site; other site
1114965000778	integrase; Provisional; Region: int; PHA02601
1114965000779	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
1114965000780	Int/Topo IB signature motif; other site
1114965000781	Domain of unknown function (DUF3173); Region: DUF3173; pfam11372
1114965000782	Replication initiation factor; Region: Rep_trans; pfam02486
1114965000783	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1114965000784	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1114965000785	non-specific DNA binding site [nucleotide binding]; other site
1114965000786	salt bridge; other site
1114965000787	sequence-specific DNA binding site [nucleotide binding]; other site
1114965000788	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1114965000789	catalytic core [active]
1114965000790	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1114965000791	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1114965000792	putative DNA binding site [nucleotide binding]; other site
1114965000793	putative Zn2+ binding site [ion binding]; other site
1114965000794	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1114965000795	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1114965000796	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1114965000797	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1114965000798	ABC-ATPase subunit  interface; other site
1114965000799	dimer interface [polypeptide binding]; other site
1114965000800	putative PBP binding regions; other site
1114965000801	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
1114965000802	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
1114965000803	metal binding site [ion binding]; metal-binding site
1114965000804	YodA lipocalin-like domain; Region: YodA; pfam09223
1114965000805	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1114965000806	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1114965000807	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1114965000808	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
1114965000809	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
1114965000810	Uncharacterized conserved protein [Function unknown]; Region: COG3538
1114965000811	Protein of unknown function (DUF1237); Region: DUF1237; pfam06824
1114965000812	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
1114965000813	N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814
1114965000814	active site
1114965000815	metal binding site [ion binding]; metal-binding site
1114965000816	homodimer interface [polypeptide binding]; other site
1114965000817	catalytic site [active]
1114965000818	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
1114965000819	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1114965000820	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1114965000821	nucleotide binding site [chemical binding]; other site
1114965000822	Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA  is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565
1114965000823	putative active site [active]
1114965000824	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1114965000825	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1114965000826	dimer interface [polypeptide binding]; other site
1114965000827	conserved gate region; other site
1114965000828	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1114965000829	ABC-ATPase subunit interface; other site
1114965000830	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1114965000831	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1114965000832	dimer interface [polypeptide binding]; other site
1114965000833	conserved gate region; other site
1114965000834	putative PBP binding loops; other site
1114965000835	ABC-ATPase subunit interface; other site
1114965000836	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1114965000837	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1114965000838	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
1114965000839	Protein of unknown function, DUF624; Region: DUF624; cl02369
1114965000840	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1114965000841	Histidine kinase; Region: His_kinase; pfam06580
1114965000842	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1114965000843	ATP binding site [chemical binding]; other site
1114965000844	Mg2+ binding site [ion binding]; other site
1114965000845	G-X-G motif; other site
1114965000846	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
1114965000847	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1114965000848	active site
1114965000849	phosphorylation site [posttranslational modification]
1114965000850	intermolecular recognition site; other site
1114965000851	dimerization interface [polypeptide binding]; other site
1114965000852	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1114965000853	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1114965000854	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1114965000855	WHG domain; Region: WHG; pfam13305
1114965000856	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
1114965000857	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1114965000858	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
1114965000859	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1114965000860	S-adenosylmethionine binding site [chemical binding]; other site
1114965000861	Predicted transcriptional regulators [Transcription]; Region: COG1733
1114965000862	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1114965000863	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1114965000864	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1114965000865	Walker A/P-loop; other site
1114965000866	ATP binding site [chemical binding]; other site
1114965000867	Q-loop/lid; other site
1114965000868	ABC transporter signature motif; other site
1114965000869	Walker B; other site
1114965000870	D-loop; other site
1114965000871	H-loop/switch region; other site
1114965000872	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
1114965000873	LytTr DNA-binding domain; Region: LytTR; smart00850
1114965000874	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
1114965000875	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
1114965000876	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
1114965000877	active site
1114965000878	HIGH motif; other site
1114965000879	dimer interface [polypeptide binding]; other site
1114965000880	KMSKS motif; other site
1114965000881	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1114965000882	RNA binding surface [nucleotide binding]; other site
1114965000883	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
1114965000884	Transglycosylase; Region: Transgly; pfam00912
1114965000885	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1114965000886	DNA-directed RNA polymerase, beta subunit/140 kD subunit [Transcription]; Region: RpoB; COG0085
1114965000887	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1114965000888	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
1114965000889	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1114965000890	RPB1 interaction site [polypeptide binding]; other site
1114965000891	RPB10 interaction site [polypeptide binding]; other site
1114965000892	RPB11 interaction site [polypeptide binding]; other site
1114965000893	RPB3 interaction site [polypeptide binding]; other site
1114965000894	RPB12 interaction site [polypeptide binding]; other site
1114965000895	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
1114965000896	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
1114965000897	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
1114965000898	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1114965000899	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
1114965000900	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1114965000901	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
1114965000902	G-loop; other site
1114965000903	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1114965000904	DNA binding site [nucleotide binding]
1114965000905	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1114965000906	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
1114965000907	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
1114965000908	active site
1114965000909	homodimer interface [polypeptide binding]; other site
1114965000910	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1114965000911	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
1114965000912	DXD motif; other site
1114965000913	Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351
1114965000914	Protein of unknown function (DUF1033); Region: DUF1033; pfam06279
1114965000915	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1114965000916	Walker A motif; other site
1114965000917	ATP binding site [chemical binding]; other site
1114965000918	Walker B motif; other site
1114965000919	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
1114965000920	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1114965000921	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1114965000922	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
1114965000923	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
1114965000924	Type II secretory pathway pseudopilin; Region: PulG; pfam11773
1114965000925	Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940
1114965000926	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
1114965000927	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1114965000928	S-adenosylmethionine binding site [chemical binding]; other site
1114965000929	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
1114965000930	propionate/acetate kinase; Provisional; Region: PRK12379
1114965000931	CAAX protease self-immunity; Region: Abi; pfam02517
1114965000932	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1114965000933	dihydropteroate synthase; Region: DHPS; TIGR01496
1114965000934	substrate binding pocket [chemical binding]; other site
1114965000935	dimer interface [polypeptide binding]; other site
1114965000936	inhibitor binding site; inhibition site
1114965000937	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
1114965000938	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1114965000939	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1114965000940	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
1114965000941	homodecamer interface [polypeptide binding]; other site
1114965000942	GTP cyclohydrolase I; Provisional; Region: PLN03044
1114965000943	active site
1114965000944	putative catalytic site residues [active]
1114965000945	zinc binding site [ion binding]; other site
1114965000946	GTP-CH-I/GFRP interaction surface; other site
1114965000947	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
1114965000948	homooctamer interface [polypeptide binding]; other site
1114965000949	active site
1114965000950	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
1114965000951	catalytic center binding site [active]
1114965000952	ATP binding site [chemical binding]; other site
1114965000953	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868
1114965000954	hypothetical protein; Provisional; Region: PRK13663
1114965000955	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
1114965000956	M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638
1114965000957	oligomer interface [polypeptide binding]; other site
1114965000958	active site
1114965000959	metal binding site [ion binding]; metal-binding site
1114965000960	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1114965000961	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1114965000962	catalytic residues [active]
1114965000963	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1114965000964	putative tRNA-binding site [nucleotide binding]; other site
1114965000965	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1114965000966	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1114965000967	dimer interface [polypeptide binding]; other site
1114965000968	ssDNA binding site [nucleotide binding]; other site
1114965000969	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1114965000970	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1114965000971	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
1114965000972	ligand binding site [chemical binding]; other site
1114965000973	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1114965000974	Histidine kinase; Region: HisKA_3; pfam07730
1114965000975	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1114965000976	ATP binding site [chemical binding]; other site
1114965000977	Mg2+ binding site [ion binding]; other site
1114965000978	G-X-G motif; other site
1114965000979	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1114965000980	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1114965000981	active site
1114965000982	phosphorylation site [posttranslational modification]
1114965000983	intermolecular recognition site; other site
1114965000984	dimerization interface [polypeptide binding]; other site
1114965000985	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1114965000986	DNA binding residues [nucleotide binding]
1114965000987	dimerization interface [polypeptide binding]; other site
1114965000988	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1114965000989	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1114965000990	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
1114965000991	active pocket/dimerization site; other site
1114965000992	active site
1114965000993	phosphorylation site [posttranslational modification]
1114965000994	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
1114965000995	active site
1114965000996	phosphorylation site [posttranslational modification]
1114965000997	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
1114965000998	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
1114965000999	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1114965001000	oligomerisation interface [polypeptide binding]; other site
1114965001001	mobile loop; other site
1114965001002	roof hairpin; other site
1114965001003	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1114965001004	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1114965001005	ring oligomerisation interface [polypeptide binding]; other site
1114965001006	ATP/Mg binding site [chemical binding]; other site
1114965001007	stacking interactions; other site
1114965001008	hinge regions; other site
1114965001009	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1114965001010	LytTr DNA-binding domain; Region: LytTR; pfam04397
1114965001011	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1114965001012	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1114965001013	ATP binding site [chemical binding]; other site
1114965001014	Mg2+ binding site [ion binding]; other site
1114965001015	G-X-G motif; other site
1114965001016	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1114965001017	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1114965001018	Walker A/P-loop; other site
1114965001019	ATP binding site [chemical binding]; other site
1114965001020	Q-loop/lid; other site
1114965001021	ABC transporter signature motif; other site
1114965001022	Walker B; other site
1114965001023	D-loop; other site
1114965001024	H-loop/switch region; other site
1114965001025	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1114965001026	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1114965001027	DNA binding site [nucleotide binding]
1114965001028	domain linker motif; other site
1114965001029	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1114965001030	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1114965001031	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1114965001032	active site
1114965001033	motif I; other site
1114965001034	motif II; other site
1114965001035	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1114965001036	Predicted membrane protein [Function unknown]; Region: COG2855
1114965001037	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1114965001038	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1114965001039	non-specific DNA binding site [nucleotide binding]; other site
1114965001040	salt bridge; other site
1114965001041	sequence-specific DNA binding site [nucleotide binding]; other site
1114965001042	Replication initiation factor; Region: Rep_trans; pfam02486
1114965001043	Domain of unknown function (DUF3173); Region: DUF3173; pfam11372
1114965001044	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
1114965001045	Int/Topo IB signature motif; other site
1114965001046	recombination factor protein RarA; Reviewed; Region: PRK13342
1114965001047	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1114965001048	Walker A motif; other site
1114965001049	ATP binding site [chemical binding]; other site
1114965001050	Walker B motif; other site
1114965001051	arginine finger; other site
1114965001052	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1114965001053	Protein of unknown function (DUF3013); Region: DUF3013; pfam11217
1114965001054	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1114965001055	nudix motif; other site
1114965001056	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
1114965001057	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1114965001058	S-adenosylmethionine binding site [chemical binding]; other site
1114965001059	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
1114965001060	RNA methyltransferase, RsmE family; Region: TIGR00046
1114965001061	Protein of unknown function (DUF1310); Region: DUF1310; pfam07006
1114965001062	Protein of unknown function (DUF1310); Region: DUF1310; pfam07006
1114965001063	Protein of unknown function (DUF1310); Region: DUF1310; pfam07006
1114965001064	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1114965001065	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1114965001066	Zn2+ binding site [ion binding]; other site
1114965001067	Mg2+ binding site [ion binding]; other site
1114965001068	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1114965001069	synthetase active site [active]
1114965001070	NTP binding site [chemical binding]; other site
1114965001071	metal binding site [ion binding]; metal-binding site
1114965001072	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1114965001073	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1114965001074	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
1114965001075	putative active site [active]
1114965001076	dimerization interface [polypeptide binding]; other site
1114965001077	putative tRNAtyr binding site [nucleotide binding]; other site
1114965001078	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
1114965001079	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
1114965001080	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
1114965001081	FeoA domain; Region: FeoA; pfam04023
1114965001082	Protein of unknown function (DUF3114); Region: DUF3114; pfam11311
1114965001083	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
1114965001084	dimer interface [polypeptide binding]; other site
1114965001085	catalytic triad [active]
1114965001086	peroxidatic and resolving cysteines [active]
1114965001087	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
1114965001088	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
1114965001089	metal binding site [ion binding]; metal-binding site
1114965001090	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1114965001091	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1114965001092	ABC-ATPase subunit  interface; other site
1114965001093	dimer interface [polypeptide binding]; other site
1114965001094	putative PBP binding regions; other site
1114965001095	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1114965001096	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1114965001097	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
1114965001098	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
1114965001099	active site
1114965001100	Zn binding site [ion binding]; other site
1114965001101	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
1114965001102	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1114965001103	FeS/SAM binding site; other site
1114965001104	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1114965001105	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
1114965001106	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1114965001107	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
1114965001108	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1114965001109	non-specific DNA interactions [nucleotide binding]; other site
1114965001110	DNA binding site [nucleotide binding]
1114965001111	sequence specific DNA binding site [nucleotide binding]; other site
1114965001112	putative cAMP binding site [chemical binding]; other site
1114965001113	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
1114965001114	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
1114965001115	active site
1114965001116	methionine cluster; other site
1114965001117	phosphorylation site [posttranslational modification]
1114965001118	metal binding site [ion binding]; metal-binding site
1114965001119	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
1114965001120	active site
1114965001121	P-loop; other site
1114965001122	phosphorylation site [posttranslational modification]
1114965001123	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1114965001124	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
1114965001125	Pyruvate-formate lyase [Energy production and conversion]; Region: PflD; COG1882
1114965001126	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
1114965001127	dimer interface [polypeptide binding]; other site
1114965001128	active site
1114965001129	glycine loop; other site
1114965001130	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
1114965001131	active site
1114965001132	intersubunit interactions; other site
1114965001133	catalytic residue [active]
1114965001134	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
1114965001135	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
1114965001136	dimer interface [polypeptide binding]; other site
1114965001137	active site
1114965001138	metal binding site [ion binding]; metal-binding site
1114965001139	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1114965001140	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1114965001141	Domain of unknown function (DUF1958); Region: DUF1958; pfam09211
1114965001142	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1114965001143	peptide binding site [polypeptide binding]; other site
1114965001144	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1114965001145	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1114965001146	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1114965001147	HIGH motif; other site
1114965001148	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1114965001149	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1114965001150	active site
1114965001151	KMSKS motif; other site
1114965001152	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1114965001153	tRNA binding surface [nucleotide binding]; other site
1114965001154	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
1114965001155	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1114965001156	dimerization interface [polypeptide binding]; other site
1114965001157	putative Zn2+ binding site [ion binding]; other site
1114965001158	putative DNA binding site [nucleotide binding]; other site
1114965001159	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1114965001160	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
1114965001161	NADP binding site [chemical binding]; other site
1114965001162	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1114965001163	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1114965001164	Walker A/P-loop; other site
1114965001165	ATP binding site [chemical binding]; other site
1114965001166	Q-loop/lid; other site
1114965001167	ABC transporter signature motif; other site
1114965001168	Walker B; other site
1114965001169	D-loop; other site
1114965001170	H-loop/switch region; other site
1114965001171	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1114965001172	dimer interface [polypeptide binding]; other site
1114965001173	conserved gate region; other site
1114965001174	ABC-ATPase subunit interface; other site
1114965001175	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
1114965001176	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
1114965001177	Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231
1114965001178	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1114965001179	minor groove reading motif; other site
1114965001180	helix-hairpin-helix signature motif; other site
1114965001181	active site
1114965001182	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
1114965001183	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
1114965001184	catalytic triad [active]
1114965001185	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
1114965001186	beta-galactosidase; Region: BGL; TIGR03356
1114965001187	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
1114965001188	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
1114965001189	glutaminase active site [active]
1114965001190	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1114965001191	dimer interface [polypeptide binding]; other site
1114965001192	active site
1114965001193	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1114965001194	dimer interface [polypeptide binding]; other site
1114965001195	active site
1114965001196	HAD superfamily, subfamily IIIB (Acid phosphatase); Region: Acid_phosphat_B; cl17236
1114965001197	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
1114965001198	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
1114965001199	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1114965001200	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1114965001201	substrate binding pocket [chemical binding]; other site
1114965001202	membrane-bound complex binding site; other site
1114965001203	hinge residues; other site
1114965001204	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1114965001205	dimer interface [polypeptide binding]; other site
1114965001206	conserved gate region; other site
1114965001207	putative PBP binding loops; other site
1114965001208	ABC-ATPase subunit interface; other site
1114965001209	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1114965001210	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1114965001211	dimer interface [polypeptide binding]; other site
1114965001212	conserved gate region; other site
1114965001213	putative PBP binding loops; other site
1114965001214	ABC-ATPase subunit interface; other site
1114965001215	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1114965001216	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1114965001217	Walker A/P-loop; other site
1114965001218	ATP binding site [chemical binding]; other site
1114965001219	Q-loop/lid; other site
1114965001220	ABC transporter signature motif; other site
1114965001221	Walker B; other site
1114965001222	D-loop; other site
1114965001223	H-loop/switch region; other site
1114965001224	Protein of unknown function (DUF1310); Region: DUF1310; pfam07006
1114965001225	Protein of unknown function (DUF1310); Region: DUF1310; pfam07006
1114965001226	Protein of unknown function (DUF1310); Region: DUF1310; pfam07006
1114965001227	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1114965001228	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
1114965001229	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1114965001230	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1114965001231	Walker A motif; other site
1114965001232	ATP binding site [chemical binding]; other site
1114965001233	Walker B motif; other site
1114965001234	arginine finger; other site
1114965001235	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1114965001236	Walker A motif; other site
1114965001237	ATP binding site [chemical binding]; other site
1114965001238	Walker B motif; other site
1114965001239	arginine finger; other site
1114965001240	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1114965001241	preprotein translocase subunit YajC; Validated; Region: yajC; PRK06531
1114965001242	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
1114965001243	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
1114965001244	catalytic residue [active]
1114965001245	putative FPP diphosphate  binding site; other site
1114965001246	putative FPP binding hydrophobic cleft; other site
1114965001247	dimer interface [polypeptide binding]; other site
1114965001248	putative IPP diphosphate binding site; other site
1114965001249	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1114965001250	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
1114965001251	RIP metalloprotease RseP; Region: TIGR00054
1114965001252	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1114965001253	active site
1114965001254	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
1114965001255	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1114965001256	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1114965001257	putative substrate binding region [chemical binding]; other site
1114965001258	prolyl-tRNA synthetase; Provisional; Region: PRK09194
1114965001259	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
1114965001260	dimer interface [polypeptide binding]; other site
1114965001261	motif 1; other site
1114965001262	active site
1114965001263	motif 2; other site
1114965001264	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
1114965001265	putative deacylase active site [active]
1114965001266	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1114965001267	active site
1114965001268	motif 3; other site
1114965001269	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1114965001270	anticodon binding site; other site
1114965001271	WXG100 family type VII secretion target; Region: WXG100_ESAT6; TIGR03930
1114965001272	type VII secretion protein EsaA, N-terminal domain; Region: T7_esaA_Nterm; TIGR03929
1114965001273	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1114965001274	WXG100 protein secretion system (Wss), protein EssA; Region: EssA; cl11266
1114965001275	WXG100 protein secretion system (Wss), protein YukD; Region: YukD; cl17489
1114965001276	type VII secretion protein EssB; Region: T7_EssB; TIGR03926
1114965001277	WXG100 protein secretion system (Wss), protein YukC; Region: YukC; cl01868
1114965001278	DNA transporter; Region: FtsK_SpoIIIE_N; pfam12538
1114965001279	type VII secretion protein EssC, C-terminal domain; Region: T7_EssCb_Firm; TIGR03928
1114965001280	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1114965001281	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1114965001282	Walker A motif; other site
1114965001283	ATP binding site [chemical binding]; other site
1114965001284	Walker B motif; other site
1114965001285	type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197
1114965001286	Domain of unknown function (DUF4176); Region: DUF4176; pfam13780
1114965001287	DNA polymerase III PolC; Validated; Region: polC; PRK00448
1114965001288	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
1114965001289	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
1114965001290	generic binding surface II; other site
1114965001291	generic binding surface I; other site
1114965001292	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
1114965001293	active site
1114965001294	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1114965001295	active site
1114965001296	catalytic site [active]
1114965001297	substrate binding site [chemical binding]; other site
1114965001298	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
1114965001299	putative PHP Thumb interface [polypeptide binding]; other site
1114965001300	active site
1114965001301	addiction module antitoxin, RelB/DinJ family; Region: RelB_DinJ; TIGR02384
1114965001302	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041
1114965001303	stage V sporulation protein K; Region: spore_V_K; TIGR02881
1114965001304	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1114965001305	Walker A motif; other site
1114965001306	ATP binding site [chemical binding]; other site
1114965001307	Walker B motif; other site
1114965001308	arginine finger; other site
1114965001309	stage V sporulation protein K; Region: spore_V_K; TIGR02881
1114965001310	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1114965001311	Walker A motif; other site
1114965001312	ATP binding site [chemical binding]; other site
1114965001313	Walker B motif; other site
1114965001314	arginine finger; other site
1114965001315	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
1114965001316	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
1114965001317	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1114965001318	active site
1114965001319	catalytic residues [active]
1114965001320	metal binding site [ion binding]; metal-binding site
1114965001321	DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402
1114965001322	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1114965001323	ligand binding site [chemical binding]; other site
1114965001324	flexible hinge region; other site
1114965001325	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
1114965001326	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1114965001327	putative substrate translocation pore; other site
1114965001328	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1114965001329	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1114965001330	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1114965001331	putative substrate translocation pore; other site
1114965001332	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1114965001333	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1114965001334	RNA binding surface [nucleotide binding]; other site
1114965001335	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
1114965001336	active site
1114965001337	uracil binding [chemical binding]; other site
1114965001338	Cna protein B-type domain; Region: Cna_B; pfam05738
1114965001339	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
1114965001340	domain interaction interfaces [polypeptide binding]; other site
1114965001341	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
1114965001342	domain interaction interfaces [polypeptide binding]; other site
1114965001343	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
1114965001344	16S/18S rRNA binding site [nucleotide binding]; other site
1114965001345	S13e-L30e interaction site [polypeptide binding]; other site
1114965001346	25S rRNA binding site [nucleotide binding]; other site
1114965001347	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1114965001348	Protein of unknown function (DUF2785); Region: DUF2785; pfam10978
1114965001349	oligoendopeptidase F; Region: pepF; TIGR00181
1114965001350	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
1114965001351	Zn binding site [ion binding]; other site
1114965001352	SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320
1114965001353	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
1114965001354	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
1114965001355	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
1114965001356	RNase E interface [polypeptide binding]; other site
1114965001357	trimer interface [polypeptide binding]; other site
1114965001358	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
1114965001359	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
1114965001360	RNase E interface [polypeptide binding]; other site
1114965001361	trimer interface [polypeptide binding]; other site
1114965001362	active site
1114965001363	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
1114965001364	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
1114965001365	RNA binding site [nucleotide binding]; other site
1114965001366	domain interface; other site
1114965001367	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
1114965001368	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1114965001369	trimer interface [polypeptide binding]; other site
1114965001370	active site
1114965001371	substrate binding site [chemical binding]; other site
1114965001372	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1114965001373	Coenzyme A binding pocket [chemical binding]; other site
1114965001374	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1114965001375	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1114965001376	Coenzyme A binding pocket [chemical binding]; other site
1114965001377	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
1114965001378	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1114965001379	active site
1114965001380	HIGH motif; other site
1114965001381	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1114965001382	KMSKS motif; other site
1114965001383	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1114965001384	tRNA binding surface [nucleotide binding]; other site
1114965001385	anticodon binding site; other site
1114965001386	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1114965001387	active site
1114965001388	metal binding site [ion binding]; metal-binding site
1114965001389	dimerization interface [polypeptide binding]; other site
1114965001390	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
1114965001391	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1114965001392	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1114965001393	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1114965001394	Walker A/P-loop; other site
1114965001395	ATP binding site [chemical binding]; other site
1114965001396	Q-loop/lid; other site
1114965001397	ABC transporter signature motif; other site
1114965001398	Walker B; other site
1114965001399	D-loop; other site
1114965001400	H-loop/switch region; other site
1114965001401	TOBE domain; Region: TOBE_2; pfam08402
1114965001402	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1114965001403	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1114965001404	Ca binding site [ion binding]; other site
1114965001405	active site
1114965001406	catalytic site [active]
1114965001407	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
1114965001408	active site
1114965001409	Zn binding site [ion binding]; other site
1114965001410	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
1114965001411	Predicted membrane protein [Function unknown]; Region: COG4129
1114965001412	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
1114965001413	DUF939 C-terminal domain; Region: DUF939_C; pfam11728
1114965001414	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1114965001415	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
1114965001416	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1114965001417	YacP-like NYN domain; Region: NYN_YacP; pfam05991
1114965001418	EDD domain protein, DegV family; Region: DegV; TIGR00762
1114965001419	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1114965001420	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
1114965001421	23S rRNA interface [nucleotide binding]; other site
1114965001422	L3 interface [polypeptide binding]; other site
1114965001423	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
1114965001424	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
1114965001425	Penicillinase repressor; Region: Pencillinase_R; pfam03965
1114965001426	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
1114965001427	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1114965001428	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1114965001429	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
1114965001430	Cadmium resistance transporter; Region: Cad; pfam03596
1114965001431	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1114965001432	putative DNA binding site [nucleotide binding]; other site
1114965001433	putative Zn2+ binding site [ion binding]; other site
1114965001434	Protein of unknown function (DUF1211); Region: DUF1211; cl01421
1114965001435	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1114965001436	non-specific DNA binding site [nucleotide binding]; other site
1114965001437	salt bridge; other site
1114965001438	sequence-specific DNA binding site [nucleotide binding]; other site
1114965001439	PspC domain; Region: PspC; pfam04024
1114965001440	Protein of unknown function (DUF3169); Region: DUF3169; pfam11368
1114965001441	CsbD-like; Region: CsbD; cl17424
1114965001442	Rhomboid family; Region: Rhomboid; cl11446
1114965001443	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1114965001444	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
1114965001445	putative NAD(P) binding site [chemical binding]; other site
1114965001446	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1114965001447	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1114965001448	VanZ like family; Region: VanZ; cl01971
1114965001449	RDD family; Region: RDD; pfam06271
1114965001450	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
1114965001451	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
1114965001452	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1114965001453	catalytic core [active]
1114965001454	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1114965001455	catalytic core [active]
1114965001456	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
1114965001457	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
1114965001458	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
1114965001459	GrpE; Region: GrpE; pfam01025
1114965001460	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1114965001461	dimer interface [polypeptide binding]; other site
1114965001462	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1114965001463	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1114965001464	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
1114965001465	nucleotide binding site [chemical binding]; other site
1114965001466	NEF interaction site [polypeptide binding]; other site
1114965001467	SBD interface [polypeptide binding]; other site
1114965001468	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
1114965001469	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1114965001470	conserved cys residue [active]
1114965001471	chaperone protein DnaJ; Provisional; Region: PRK14276
1114965001472	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1114965001473	HSP70 interaction site [polypeptide binding]; other site
1114965001474	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
1114965001475	substrate binding site [polypeptide binding]; other site
1114965001476	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1114965001477	Zn binding sites [ion binding]; other site
1114965001478	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1114965001479	dimer interface [polypeptide binding]; other site
1114965001480	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
1114965001481	Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564
1114965001482	N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525
1114965001483	active site
1114965001484	Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564
1114965001485	active site
1114965001486	G5 domain; Region: G5; pfam07501
1114965001487	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
1114965001488	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1114965001489	dimerization interface 3.5A [polypeptide binding]; other site
1114965001490	active site
1114965001491	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
1114965001492	substrate binding site [chemical binding]; other site
1114965001493	dimer interface [polypeptide binding]; other site
1114965001494	ATP binding site [chemical binding]; other site
1114965001495	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155
1114965001496	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
1114965001497	Protein of unknown function (DUF436); Region: DUF436; cl01860
1114965001498	Protein of unknown function (DUF436); Region: DUF436; cl01860
1114965001499	trigger factor; Provisional; Region: tig; PRK01490
1114965001500	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1114965001501	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1114965001502	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066
1114965001503	Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382
1114965001504	B3/4 domain; Region: B3_4; pfam03483
1114965001505	CTP synthetase; Validated; Region: pyrG; PRK05380
1114965001506	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
1114965001507	Catalytic site [active]
1114965001508	active site
1114965001509	UTP binding site [chemical binding]; other site
1114965001510	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
1114965001511	active site
1114965001512	putative oxyanion hole; other site
1114965001513	catalytic triad [active]
1114965001514	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
1114965001515	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1114965001516	intersubunit interface [polypeptide binding]; other site
1114965001517	active site
1114965001518	zinc binding site [ion binding]; other site
1114965001519	Na+ binding site [ion binding]; other site
1114965001520	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1114965001521	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1114965001522	catalytic core [active]
1114965001523	Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435
1114965001524	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
1114965001525	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1114965001526	Walker A/P-loop; other site
1114965001527	ATP binding site [chemical binding]; other site
1114965001528	Q-loop/lid; other site
1114965001529	ABC transporter signature motif; other site
1114965001530	Walker B; other site
1114965001531	D-loop; other site
1114965001532	H-loop/switch region; other site
1114965001533	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
1114965001534	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
1114965001535	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG3694
1114965001536	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1114965001537	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1114965001538	Coenzyme A binding pocket [chemical binding]; other site
1114965001539	stage V sporulation protein K; Region: spore_V_K; TIGR02881
1114965001540	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1114965001541	Walker A motif; other site
1114965001542	ATP binding site [chemical binding]; other site
1114965001543	Walker B motif; other site
1114965001544	arginine finger; other site
1114965001545	Predicted transcriptional regulator [Transcription]; Region: COG2378
1114965001546	HTH domain; Region: HTH_11; cl17392
1114965001547	WYL domain; Region: WYL; pfam13280
1114965001548	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1114965001549	LytTr DNA-binding domain; Region: LytTR; smart00850
1114965001550	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1114965001551	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
1114965001552	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
1114965001553	DAK2 domain; Region: Dak2; pfam02734
1114965001554	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1114965001555	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1114965001556	Walker A/P-loop; other site
1114965001557	ATP binding site [chemical binding]; other site
1114965001558	Q-loop/lid; other site
1114965001559	ABC transporter signature motif; other site
1114965001560	Walker B; other site
1114965001561	D-loop; other site
1114965001562	H-loop/switch region; other site
1114965001563	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1114965001564	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1114965001565	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
1114965001566	Histidine kinase; Region: HisKA_3; pfam07730
1114965001567	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
1114965001568	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1114965001569	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1114965001570	active site
1114965001571	phosphorylation site [posttranslational modification]
1114965001572	intermolecular recognition site; other site
1114965001573	dimerization interface [polypeptide binding]; other site
1114965001574	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1114965001575	DNA binding residues [nucleotide binding]
1114965001576	dimerization interface [polypeptide binding]; other site
1114965001577	acetolactate synthase catalytic subunit; Reviewed; Region: PRK07282
1114965001578	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1114965001579	PYR/PP interface [polypeptide binding]; other site
1114965001580	dimer interface [polypeptide binding]; other site
1114965001581	TPP binding site [chemical binding]; other site
1114965001582	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1114965001583	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1114965001584	TPP-binding site [chemical binding]; other site
1114965001585	dimer interface [polypeptide binding]; other site
1114965001586	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
1114965001587	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
1114965001588	putative valine binding site [chemical binding]; other site
1114965001589	dimer interface [polypeptide binding]; other site
1114965001590	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
1114965001591	ketol-acid reductoisomerase; Provisional; Region: PRK05479
1114965001592	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
1114965001593	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1114965001594	threonine dehydratase; Validated; Region: PRK08639
1114965001595	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1114965001596	tetramer interface [polypeptide binding]; other site
1114965001597	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1114965001598	catalytic residue [active]
1114965001599	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1114965001600	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1114965001601	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_4; cd03407
1114965001602	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1114965001603	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1114965001604	Walker A/P-loop; other site
1114965001605	ATP binding site [chemical binding]; other site
1114965001606	Q-loop/lid; other site
1114965001607	ABC transporter signature motif; other site
1114965001608	Walker B; other site
1114965001609	D-loop; other site
1114965001610	H-loop/switch region; other site
1114965001611	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1114965001612	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1114965001613	substrate binding pocket [chemical binding]; other site
1114965001614	membrane-bound complex binding site; other site
1114965001615	hinge residues; other site
1114965001616	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1114965001617	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1114965001618	dimer interface [polypeptide binding]; other site
1114965001619	conserved gate region; other site
1114965001620	putative PBP binding loops; other site
1114965001621	ABC-ATPase subunit interface; other site
1114965001622	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
1114965001623	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
1114965001624	adaptor protein; Provisional; Region: PRK02315
1114965001625	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
1114965001626	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
1114965001627	Mg++ binding site [ion binding]; other site
1114965001628	putative catalytic motif [active]
1114965001629	substrate binding site [chemical binding]; other site
1114965001630	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
1114965001631	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
1114965001632	Walker A/P-loop; other site
1114965001633	ATP binding site [chemical binding]; other site
1114965001634	Q-loop/lid; other site
1114965001635	ABC transporter signature motif; other site
1114965001636	Walker B; other site
1114965001637	D-loop; other site
1114965001638	H-loop/switch region; other site
1114965001639	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
1114965001640	FeS assembly protein SufD; Region: sufD; TIGR01981
1114965001641	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1114965001642	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1114965001643	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1114965001644	catalytic residue [active]
1114965001645	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
1114965001646	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
1114965001647	trimerization site [polypeptide binding]; other site
1114965001648	active site
1114965001649	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
1114965001650	FeS assembly protein SufB; Region: sufB; TIGR01980
1114965001651	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
1114965001652	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1114965001653	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
1114965001654	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1114965001655	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1114965001656	peptide binding site [polypeptide binding]; other site
1114965001657	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1114965001658	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1114965001659	dimer interface [polypeptide binding]; other site
1114965001660	conserved gate region; other site
1114965001661	putative PBP binding loops; other site
1114965001662	ABC-ATPase subunit interface; other site
1114965001663	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
1114965001664	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1114965001665	dimer interface [polypeptide binding]; other site
1114965001666	conserved gate region; other site
1114965001667	putative PBP binding loops; other site
1114965001668	ABC-ATPase subunit interface; other site
1114965001669	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1114965001670	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1114965001671	Walker A/P-loop; other site
1114965001672	ATP binding site [chemical binding]; other site
1114965001673	Q-loop/lid; other site
1114965001674	ABC transporter signature motif; other site
1114965001675	Walker B; other site
1114965001676	D-loop; other site
1114965001677	H-loop/switch region; other site
1114965001678	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1114965001679	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1114965001680	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1114965001681	Walker A/P-loop; other site
1114965001682	ATP binding site [chemical binding]; other site
1114965001683	Q-loop/lid; other site
1114965001684	ABC transporter signature motif; other site
1114965001685	Walker B; other site
1114965001686	D-loop; other site
1114965001687	H-loop/switch region; other site
1114965001688	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1114965001689	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
1114965001690	hypothetical protein; Provisional; Region: PRK13662
1114965001691	RecX family; Region: RecX; cl00936
1114965001692	TRAM domain; Region: TRAM; pfam01938
1114965001693	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
1114965001694	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1114965001695	S-adenosylmethionine binding site [chemical binding]; other site
1114965001696	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
1114965001697	active site
1114965001698	catalytic motif [active]
1114965001699	Zn binding site [ion binding]; other site
1114965001700	Domain of unknown function (DUF1858); Region: DUF1858; pfam08984
1114965001701	Uncharacterized conserved protein [Function unknown]; Region: COG2461
1114965001702	Family of unknown function (DUF438); Region: DUF438; pfam04282
1114965001703	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
1114965001704	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1114965001705	putative active site [active]
1114965001706	heme pocket [chemical binding]; other site
1114965001707	Domain of unknown function (DUF1912); Region: DUF1912; pfam08930
1114965001708	hypothetical protein; Provisional; Region: PRK07758
1114965001709	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
1114965001710	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1114965001711	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1114965001712	Coenzyme A binding pocket [chemical binding]; other site
1114965001713	AAA domain; Region: AAA_18; pfam13238
1114965001714	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1114965001715	active site
1114965001716	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
1114965001717	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1114965001718	active site
1114965001719	HIGH motif; other site
1114965001720	nucleotide binding site [chemical binding]; other site
1114965001721	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1114965001722	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1114965001723	active site
1114965001724	KMSKS motif; other site
1114965001725	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1114965001726	tRNA binding surface [nucleotide binding]; other site
1114965001727	anticodon binding site; other site
1114965001728	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
1114965001729	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1114965001730	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1114965001731	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
1114965001732	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1114965001733	active site
1114965001734	motif I; other site
1114965001735	motif II; other site
1114965001736	GTPase YqeH; Provisional; Region: PRK13796
1114965001737	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
1114965001738	GTP/Mg2+ binding site [chemical binding]; other site
1114965001739	G4 box; other site
1114965001740	G5 box; other site
1114965001741	G1 box; other site
1114965001742	Switch I region; other site
1114965001743	G2 box; other site
1114965001744	G3 box; other site
1114965001745	Switch II region; other site
1114965001746	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
1114965001747	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
1114965001748	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
1114965001749	active site
1114965001750	(T/H)XGH motif; other site
1114965001751	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1114965001752	Zn2+ binding site [ion binding]; other site
1114965001753	Mg2+ binding site [ion binding]; other site
1114965001754	Isochorismatase family; Region: Isochorismatase; pfam00857
1114965001755	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
1114965001756	catalytic triad [active]
1114965001757	conserved cis-peptide bond; other site
1114965001758	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
1114965001759	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
1114965001760	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1114965001761	S-adenosylmethionine binding site [chemical binding]; other site
1114965001762	hypothetical protein; Provisional; Region: PRK13670
1114965001763	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636
1114965001764	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
1114965001765	Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769
1114965001766	hypothetical protein; Provisional; Region: PRK12378
1114965001767	DNA polymerase IV; Reviewed; Region: PRK03103
1114965001768	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
1114965001769	active site
1114965001770	DNA binding site [nucleotide binding]
1114965001771	Predicted transcriptional regulator [Transcription]; Region: COG2932
1114965001772	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1114965001773	sequence-specific DNA binding site [nucleotide binding]; other site
1114965001774	salt bridge; other site
1114965001775	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1114965001776	Catalytic site [active]
1114965001777	Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia.  AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645
1114965001778	dimer interface [polypeptide binding]; other site
1114965001779	active site
1114965001780	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
1114965001781	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1114965001782	S-adenosylmethionine binding site [chemical binding]; other site
1114965001783	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
1114965001784	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1114965001785	active site
1114965001786	(T/H)XGH motif; other site
1114965001787	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
1114965001788	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
1114965001789	protein binding site [polypeptide binding]; other site
1114965001790	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1114965001791	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1114965001792	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
1114965001793	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1114965001794	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1114965001795	catalytic residues [active]
1114965001796	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
1114965001797	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
1114965001798	SelR domain; Region: SelR; pfam01641
1114965001799	Response regulator receiver domain; Region: Response_reg; pfam00072
1114965001800	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1114965001801	active site
1114965001802	phosphorylation site [posttranslational modification]
1114965001803	intermolecular recognition site; other site
1114965001804	dimerization interface [polypeptide binding]; other site
1114965001805	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1114965001806	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1114965001807	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1114965001808	Cache domain; Region: Cache_1; pfam02743
1114965001809	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1114965001810	dimerization interface [polypeptide binding]; other site
1114965001811	Histidine kinase; Region: His_kinase; pfam06580
1114965001812	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1114965001813	ATP binding site [chemical binding]; other site
1114965001814	Mg2+ binding site [ion binding]; other site
1114965001815	G-X-G motif; other site
1114965001816	Protein of unknown function (DUF1027); Region: DUF1027; cl09961
1114965001817	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455
1114965001818	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1114965001819	FeS/SAM binding site; other site
1114965001820	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
1114965001821	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
1114965001822	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1114965001823	catalytic residue [active]
1114965001824	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
1114965001825	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
1114965001826	Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014
1114965001827	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1114965001828	active site residue [active]
1114965001829	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1114965001830	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
1114965001831	RNA binding surface [nucleotide binding]; other site
1114965001832	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
1114965001833	active site
1114965001834	uracil binding [chemical binding]; other site
1114965001835	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
1114965001836	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
1114965001837	G1 box; other site
1114965001838	putative GEF interaction site [polypeptide binding]; other site
1114965001839	GTP/Mg2+ binding site [chemical binding]; other site
1114965001840	Switch I region; other site
1114965001841	G2 box; other site
1114965001842	G3 box; other site
1114965001843	Switch II region; other site
1114965001844	G4 box; other site
1114965001845	G5 box; other site
1114965001846	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1114965001847	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
1114965001848	Protein of unknown function (DUF3165); Region: DUF3165; pfam11364
1114965001849	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
1114965001850	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
1114965001851	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1114965001852	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1114965001853	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
1114965001854	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1114965001855	active site
1114965001856	homodimer interface [polypeptide binding]; other site
1114965001857	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
1114965001858	Cell division protein FtsQ; Region: FtsQ; pfam03799
1114965001859	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
1114965001860	Cell division protein FtsA; Region: FtsA; smart00842
1114965001861	Cell division protein FtsA; Region: FtsA; pfam14450
1114965001862	Domain of unknown function (DUF3484); Region: DUF3484; pfam11983
1114965001863	cell division protein FtsZ; Validated; Region: PRK09330
1114965001864	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1114965001865	nucleotide binding site [chemical binding]; other site
1114965001866	SulA interaction site; other site
1114965001867	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
1114965001868	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1114965001869	catalytic residue [active]
1114965001870	Protein of unknown function (DUF552); Region: DUF552; cl00775
1114965001871	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
1114965001872	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1114965001873	RNA binding surface [nucleotide binding]; other site
1114965001874	DivIVA domain; Region: DivI1A_domain; TIGR03544
1114965001875	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
1114965001876	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
1114965001877	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1114965001878	active site
1114965001879	HIGH motif; other site
1114965001880	nucleotide binding site [chemical binding]; other site
1114965001881	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1114965001882	active site
1114965001883	KMSKS motif; other site
1114965001884	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
1114965001885	tRNA binding surface [nucleotide binding]; other site
1114965001886	anticodon binding site; other site
1114965001887	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1114965001888	Domain of unknown function (DUF1827); Region: DUF1827; pfam08860
1114965001889	Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684
1114965001890	nudix motif; other site
1114965001891	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1114965001892	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1114965001893	Walker A motif; other site
1114965001894	ATP binding site [chemical binding]; other site
1114965001895	Walker B motif; other site
1114965001896	arginine finger; other site
1114965001897	UvrB/uvrC motif; Region: UVR; pfam02151
1114965001898	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1114965001899	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1114965001900	Walker A motif; other site
1114965001901	ATP binding site [chemical binding]; other site
1114965001902	Walker B motif; other site
1114965001903	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1114965001904	Protein of unknown function (DUF1797); Region: DUF1797; cl11550
1114965001905	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179
1114965001906	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1114965001907	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1114965001908	homodimer interface [polypeptide binding]; other site
1114965001909	NADP binding site [chemical binding]; other site
1114965001910	substrate binding site [chemical binding]; other site
1114965001911	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1114965001912	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1114965001913	active site
1114965001914	motif I; other site
1114965001915	motif II; other site
1114965001916	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
1114965001917	putative substrate binding site [chemical binding]; other site
1114965001918	putative ATP binding site [chemical binding]; other site
1114965001919	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1114965001920	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1114965001921	DNA binding site [nucleotide binding]
1114965001922	domain linker motif; other site
1114965001923	Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291
1114965001924	dimerization interface [polypeptide binding]; other site
1114965001925	ligand binding site [chemical binding]; other site
1114965001926	sodium binding site [ion binding]; other site
1114965001927	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1114965001928	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1114965001929	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1114965001930	dimer interface [polypeptide binding]; other site
1114965001931	conserved gate region; other site
1114965001932	putative PBP binding loops; other site
1114965001933	ABC-ATPase subunit interface; other site
1114965001934	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1114965001935	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1114965001936	dimer interface [polypeptide binding]; other site
1114965001937	conserved gate region; other site
1114965001938	putative PBP binding loops; other site
1114965001939	ABC-ATPase subunit interface; other site
1114965001940	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
1114965001941	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1114965001942	substrate binding [chemical binding]; other site
1114965001943	active site
1114965001944	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1114965001945	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1114965001946	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
1114965001947	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
1114965001948	generic binding surface II; other site
1114965001949	generic binding surface I; other site
1114965001950	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
1114965001951	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1114965001952	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1114965001953	substrate binding pocket [chemical binding]; other site
1114965001954	chain length determination region; other site
1114965001955	substrate-Mg2+ binding site; other site
1114965001956	catalytic residues [active]
1114965001957	aspartate-rich region 1; other site
1114965001958	active site lid residues [active]
1114965001959	aspartate-rich region 2; other site
1114965001960	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
1114965001961	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1114965001962	RNA binding surface [nucleotide binding]; other site
1114965001963	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
1114965001964	Arginine repressor [Transcription]; Region: ArgR; COG1438
1114965001965	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1114965001966	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1114965001967	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
1114965001968	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1114965001969	Walker A/P-loop; other site
1114965001970	ATP binding site [chemical binding]; other site
1114965001971	Q-loop/lid; other site
1114965001972	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1114965001973	ABC transporter signature motif; other site
1114965001974	Walker B; other site
1114965001975	D-loop; other site
1114965001976	H-loop/switch region; other site
1114965001977	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
1114965001978	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1114965001979	active site
1114965001980	metal binding site [ion binding]; metal-binding site
1114965001981	EDD domain protein, DegV family; Region: DegV; TIGR00762
1114965001982	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1114965001983	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1114965001984	IHF dimer interface [polypeptide binding]; other site
1114965001985	IHF - DNA interface [nucleotide binding]; other site
1114965001986	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1114965001987	metal binding site 2 [ion binding]; metal-binding site
1114965001988	putative DNA binding helix; other site
1114965001989	metal binding site 1 [ion binding]; metal-binding site
1114965001990	dimer interface [polypeptide binding]; other site
1114965001991	structural Zn2+ binding site [ion binding]; other site
1114965001992	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1114965001993	catalytic core [active]
1114965001994	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1114965001995	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
1114965001996	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1114965001997	active site
1114965001998	HIGH motif; other site
1114965001999	KMSKS motif; other site
1114965002000	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1114965002001	tRNA binding surface [nucleotide binding]; other site
1114965002002	anticodon binding site; other site
1114965002003	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
1114965002004	dimer interface [polypeptide binding]; other site
1114965002005	putative tRNA-binding site [nucleotide binding]; other site
1114965002006	Predicted transcriptional regulator [Transcription]; Region: COG3655
1114965002007	salt bridge; other site
1114965002008	non-specific DNA binding site [nucleotide binding]; other site
1114965002009	sequence-specific DNA binding site [nucleotide binding]; other site
1114965002010	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
1114965002011	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
1114965002012	metal binding site [ion binding]; metal-binding site
1114965002013	streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363
1114965002014	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
1114965002015	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
1114965002016	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
1114965002017	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1114965002018	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741
1114965002019	nucleophilic elbow; other site
1114965002020	catalytic triad; other site
1114965002021	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1114965002022	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1114965002023	active site
1114965002024	phosphorylation site [posttranslational modification]
1114965002025	intermolecular recognition site; other site
1114965002026	dimerization interface [polypeptide binding]; other site
1114965002027	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1114965002028	DNA binding site [nucleotide binding]
1114965002029	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1114965002030	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1114965002031	ATP binding site [chemical binding]; other site
1114965002032	Mg2+ binding site [ion binding]; other site
1114965002033	G-X-G motif; other site
1114965002034	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1114965002035	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1114965002036	Walker A/P-loop; other site
1114965002037	ATP binding site [chemical binding]; other site
1114965002038	Q-loop/lid; other site
1114965002039	ABC transporter signature motif; other site
1114965002040	Walker B; other site
1114965002041	D-loop; other site
1114965002042	H-loop/switch region; other site
1114965002043	FtsX-like permease family; Region: FtsX; pfam02687
1114965002044	Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083
1114965002045	Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083
1114965002046	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1114965002047	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1114965002048	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1114965002049	Protein of unknown function (DUF1722); Region: DUF1722; pfam08349
1114965002050	conserved hypothetical protein; Region: TIGR02328
1114965002051	Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013
1114965002052	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
1114965002053	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
1114965002054	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1114965002055	ATP binding site [chemical binding]; other site
1114965002056	putative Mg++ binding site [ion binding]; other site
1114965002057	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
1114965002058	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
1114965002059	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1114965002060	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1114965002061	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
1114965002062	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1114965002063	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
1114965002064	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1114965002065	non-specific DNA binding site [nucleotide binding]; other site
1114965002066	salt bridge; other site
1114965002067	sequence-specific DNA binding site [nucleotide binding]; other site
1114965002068	Domain of unknown function (DUF955); Region: DUF955; cl01076
1114965002069	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
1114965002070	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
1114965002071	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1114965002072	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
1114965002073	NAD binding site [chemical binding]; other site
1114965002074	dimer interface [polypeptide binding]; other site
1114965002075	substrate binding site [chemical binding]; other site
1114965002076	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
1114965002077	Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811
1114965002078	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1114965002079	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1114965002080	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1114965002081	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
1114965002082	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1114965002083	putative substrate translocation pore; other site
1114965002084	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1114965002085	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
1114965002086	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
1114965002087	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1114965002088	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1114965002089	Walker A/P-loop; other site
1114965002090	ATP binding site [chemical binding]; other site
1114965002091	Q-loop/lid; other site
1114965002092	ABC transporter signature motif; other site
1114965002093	Walker B; other site
1114965002094	D-loop; other site
1114965002095	H-loop/switch region; other site
1114965002096	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1114965002097	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1114965002098	peptide binding site [polypeptide binding]; other site
1114965002099	Predicted transcriptional regulators [Transcription]; Region: COG1695
1114965002100	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
1114965002101	amino acid transporter; Region: 2A0306; TIGR00909
1114965002102	Protein of unknown function (DUF2829); Region: DUF2829; pfam11195
1114965002103	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550
1114965002104	classical (c) SDRs; Region: SDR_c; cd05233
1114965002105	NAD(P) binding site [chemical binding]; other site
1114965002106	active site
1114965002107	Protein of unknown function (DUF1602); Region: DUF1602; pfam07673
1114965002108	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1114965002109	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1114965002110	Walker A/P-loop; other site
1114965002111	ATP binding site [chemical binding]; other site
1114965002112	Q-loop/lid; other site
1114965002113	ABC transporter signature motif; other site
1114965002114	Walker B; other site
1114965002115	D-loop; other site
1114965002116	H-loop/switch region; other site
1114965002117	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1114965002118	FtsX-like permease family; Region: FtsX; pfam02687
1114965002119	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1114965002120	nudix motif; other site
1114965002121	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
1114965002122	Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684
1114965002123	nudix motif; other site
1114965002124	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
1114965002125	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
1114965002126	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
1114965002127	Substrate binding site; other site
1114965002128	Mg++ binding site; other site
1114965002129	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
1114965002130	active site
1114965002131	substrate binding site [chemical binding]; other site
1114965002132	CoA binding site [chemical binding]; other site
1114965002133	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
1114965002134	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1114965002135	dimer interface [polypeptide binding]; other site
1114965002136	ADP-ribose binding site [chemical binding]; other site
1114965002137	active site
1114965002138	nudix motif; other site
1114965002139	metal binding site [ion binding]; metal-binding site
1114965002140	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
1114965002141	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
1114965002142	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
1114965002143	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1114965002144	minor groove reading motif; other site
1114965002145	helix-hairpin-helix signature motif; other site
1114965002146	substrate binding pocket [chemical binding]; other site
1114965002147	active site
1114965002148	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1114965002149	peptide binding site [polypeptide binding]; other site
1114965002150	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1114965002151	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
1114965002152	dimer interface [polypeptide binding]; other site
1114965002153	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1114965002154	ligand binding site [chemical binding]; other site
1114965002155	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
1114965002156	active site
1114965002157	putative catalytic site [active]
1114965002158	DNA binding site [nucleotide binding]
1114965002159	putative phosphate binding site [ion binding]; other site
1114965002160	metal binding site A [ion binding]; metal-binding site
1114965002161	AP binding site [nucleotide binding]; other site
1114965002162	metal binding site B [ion binding]; metal-binding site
1114965002163	Protein of unknown function (DUF3290); Region: DUF3290; pfam11694
1114965002164	Predicted membrane protein [Function unknown]; Region: COG2323
1114965002165	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1114965002166	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1114965002167	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1114965002168	recombination protein RecR; Reviewed; Region: recR; PRK00076
1114965002169	RecR protein; Region: RecR; pfam02132
1114965002170	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1114965002171	putative active site [active]
1114965002172	putative metal-binding site [ion binding]; other site
1114965002173	tetramer interface [polypeptide binding]; other site
1114965002174	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
1114965002175	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1114965002176	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
1114965002177	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
1114965002178	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1114965002179	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1114965002180	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1114965002181	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
1114965002182	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
1114965002183	nudix motif; other site
1114965002184	Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529
1114965002185	Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529
1114965002186	Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529
1114965002187	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
1114965002188	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
1114965002189	G1 box; other site
1114965002190	putative GEF interaction site [polypeptide binding]; other site
1114965002191	GTP/Mg2+ binding site [chemical binding]; other site
1114965002192	Switch I region; other site
1114965002193	G2 box; other site
1114965002194	G3 box; other site
1114965002195	Switch II region; other site
1114965002196	G4 box; other site
1114965002197	G5 box; other site
1114965002198	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
1114965002199	Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225
1114965002200	pentamer interface [polypeptide binding]; other site
1114965002201	dodecaamer interface [polypeptide binding]; other site
1114965002202	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
1114965002203	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
1114965002204	Cl binding site [ion binding]; other site
1114965002205	oligomer interface [polypeptide binding]; other site
1114965002206	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1114965002207	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1114965002208	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1114965002209	helicase 45; Provisional; Region: PTZ00424
1114965002210	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1114965002211	ATP binding site [chemical binding]; other site
1114965002212	Mg++ binding site [ion binding]; other site
1114965002213	motif III; other site
1114965002214	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1114965002215	nucleotide binding region [chemical binding]; other site
1114965002216	ATP-binding site [chemical binding]; other site
1114965002217	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
1114965002218	active site
1114965002219	catalytic residues [active]
1114965002220	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
1114965002221	GIY-YIG motif/motif A; other site
1114965002222	putative active site [active]
1114965002223	putative metal binding site [ion binding]; other site
1114965002224	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
1114965002225	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1114965002226	S-adenosylmethionine binding site [chemical binding]; other site
1114965002227	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1114965002228	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1114965002229	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1114965002230	motif II; other site
1114965002231	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1114965002232	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1114965002233	putative acyl-acceptor binding pocket; other site
1114965002234	SLBB domain; Region: SLBB; pfam10531
1114965002235	comEA protein; Region: comE; TIGR01259
1114965002236	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
1114965002237	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
1114965002238	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
1114965002239	Competence protein; Region: Competence; pfam03772
1114965002240	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
1114965002241	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1114965002242	Protein of unknown function (DUF805); Region: DUF805; pfam05656
1114965002243	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
1114965002244	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
1114965002245	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1114965002246	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1114965002247	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1114965002248	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
1114965002249	Domain of unknown function DUF87; Region: DUF87; pfam01935
1114965002250	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1114965002251	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1114965002252	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1114965002253	ligand binding site [chemical binding]; other site
1114965002254	flexible hinge region; other site
1114965002255	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
1114965002256	putative switch regulator; other site
1114965002257	non-specific DNA interactions [nucleotide binding]; other site
1114965002258	DNA binding site [nucleotide binding]
1114965002259	sequence specific DNA binding site [nucleotide binding]; other site
1114965002260	putative cAMP binding site [chemical binding]; other site
1114965002261	arginine deiminase; Provisional; Region: PRK01388
1114965002262	ornithine carbamoyltransferase; Validated; Region: PRK02102
1114965002263	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1114965002264	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1114965002265	carbamate kinase; Reviewed; Region: PRK12686
1114965002266	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
1114965002267	putative substrate binding site [chemical binding]; other site
1114965002268	nucleotide binding site [chemical binding]; other site
1114965002269	nucleotide binding site [chemical binding]; other site
1114965002270	homodimer interface [polypeptide binding]; other site
1114965002271	Predicted membrane protein [Function unknown]; Region: COG1288
1114965002272	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
1114965002273	hypothetical protein; Provisional; Region: PRK07205
1114965002274	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
1114965002275	active site
1114965002276	metal binding site [ion binding]; metal-binding site
1114965002277	Arginine repressor [Transcription]; Region: ArgR; COG1438
1114965002278	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1114965002279	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1114965002280	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
1114965002281	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
1114965002282	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1114965002283	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
1114965002284	active site
1114965002285	trimer interface [polypeptide binding]; other site
1114965002286	allosteric site; other site
1114965002287	active site lid [active]
1114965002288	hexamer (dimer of trimers) interface [polypeptide binding]; other site
1114965002289	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1114965002290	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1114965002291	Domain of unknown function (DUF1958); Region: DUF1958; pfam09211
1114965002292	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1114965002293	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1114965002294	putative substrate translocation pore; other site
1114965002295	Competence protein CoiA-like family; Region: CoiA; pfam06054
1114965002296	Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164
1114965002297	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
1114965002298	active site
1114965002299	Zn binding site [ion binding]; other site
1114965002300	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
1114965002301	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1114965002302	S-adenosylmethionine binding site [chemical binding]; other site
1114965002303	foldase protein PrsA; Reviewed; Region: prsA; PRK01326
1114965002304	SurA N-terminal domain; Region: SurA_N; pfam09312
1114965002305	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
1114965002306	Tubby C 2; Region: Tub_2; cl02043
1114965002307	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1114965002308	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
1114965002309	motif 1; other site
1114965002310	active site
1114965002311	motif 2; other site
1114965002312	motif 3; other site
1114965002313	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1114965002314	DHHA1 domain; Region: DHHA1; pfam02272
1114965002315	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
1114965002316	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
1114965002317	dimer interface [polypeptide binding]; other site
1114965002318	putative radical transfer pathway; other site
1114965002319	diiron center [ion binding]; other site
1114965002320	tyrosyl radical; other site
1114965002321	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306
1114965002322	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
1114965002323	Class I ribonucleotide reductase; Region: RNR_I; cd01679
1114965002324	active site
1114965002325	dimer interface [polypeptide binding]; other site
1114965002326	catalytic residues [active]
1114965002327	effector binding site; other site
1114965002328	R2 peptide binding site; other site
1114965002329	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
1114965002330	catalytic residues [active]
1114965002331	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1114965002332	dimerization domain swap beta strand [polypeptide binding]; other site
1114965002333	regulatory protein interface [polypeptide binding]; other site
1114965002334	active site
1114965002335	regulatory phosphorylation site [posttranslational modification]; other site
1114965002336	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
1114965002337	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1114965002338	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1114965002339	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1114965002340	glycogen branching enzyme; Provisional; Region: PRK12313
1114965002341	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
1114965002342	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
1114965002343	active site
1114965002344	catalytic site [active]
1114965002345	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
1114965002346	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
1114965002347	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
1114965002348	ligand binding site; other site
1114965002349	oligomer interface; other site
1114965002350	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
1114965002351	dimer interface [polypeptide binding]; other site
1114965002352	N-terminal domain interface [polypeptide binding]; other site
1114965002353	sulfate 1 binding site; other site
1114965002354	glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092
1114965002355	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1114965002356	active site
1114965002357	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
1114965002358	dimer interface [polypeptide binding]; other site
1114965002359	N-terminal domain interface [polypeptide binding]; other site
1114965002360	sulfate 1 binding site; other site
1114965002361	glycogen synthase; Provisional; Region: glgA; PRK00654
1114965002362	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
1114965002363	ADP-binding pocket [chemical binding]; other site
1114965002364	homodimer interface [polypeptide binding]; other site
1114965002365	G5 domain; Region: G5; pfam07501
1114965002366	G5 domain; Region: G5; pfam07501
1114965002367	G5 domain; Region: G5; pfam07501
1114965002368	M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342
1114965002369	M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580
1114965002370	F0F1 ATP synthase subunit C; Provisional; Region: PRK13467
1114965002371	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
1114965002372	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
1114965002373	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
1114965002374	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
1114965002375	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
1114965002376	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
1114965002377	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1114965002378	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1114965002379	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
1114965002380	beta subunit interaction interface [polypeptide binding]; other site
1114965002381	Walker A motif; other site
1114965002382	ATP binding site [chemical binding]; other site
1114965002383	Walker B motif; other site
1114965002384	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1114965002385	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1114965002386	core domain interface [polypeptide binding]; other site
1114965002387	delta subunit interface [polypeptide binding]; other site
1114965002388	epsilon subunit interface [polypeptide binding]; other site
1114965002389	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1114965002390	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1114965002391	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1114965002392	alpha subunit interaction interface [polypeptide binding]; other site
1114965002393	Walker A motif; other site
1114965002394	ATP binding site [chemical binding]; other site
1114965002395	Walker B motif; other site
1114965002396	inhibitor binding site; inhibition site
1114965002397	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1114965002398	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
1114965002399	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
1114965002400	gamma subunit interface [polypeptide binding]; other site
1114965002401	epsilon subunit interface [polypeptide binding]; other site
1114965002402	LBP interface [polypeptide binding]; other site
1114965002403	Protein of unknown function (DUF1146); Region: DUF1146; cl11486
1114965002404	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1114965002405	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1114965002406	hinge; other site
1114965002407	active site
1114965002408	DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772
1114965002409	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; pfam01223
1114965002410	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
1114965002411	Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268
1114965002412	active site
1114965002413	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1114965002414	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1114965002415	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1114965002416	Walker A/P-loop; other site
1114965002417	ATP binding site [chemical binding]; other site
1114965002418	Q-loop/lid; other site
1114965002419	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1114965002420	ABC transporter signature motif; other site
1114965002421	Walker B; other site
1114965002422	D-loop; other site
1114965002423	ABC transporter; Region: ABC_tran_2; pfam12848
1114965002424	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1114965002425	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1114965002426	non-specific DNA binding site [nucleotide binding]; other site
1114965002427	salt bridge; other site
1114965002428	sequence-specific DNA binding site [nucleotide binding]; other site
1114965002429	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
1114965002430	H+ Antiporter protein; Region: 2A0121; TIGR00900
1114965002431	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1114965002432	putative substrate translocation pore; other site
1114965002433	H+ Antiporter protein; Region: 2A0121; TIGR00900
1114965002434	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1114965002435	Protein of unknown function (DUF1049); Region: DUF1049; pfam06305
1114965002436	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
1114965002437	catalytic triad [active]
1114965002438	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
1114965002439	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1114965002440	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
1114965002441	Uncharacterized conserved protein [Function unknown]; Region: COG1624
1114965002442	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
1114965002443	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
1114965002444	YbbR-like protein; Region: YbbR; pfam07949
1114965002445	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
1114965002446	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
1114965002447	active site
1114965002448	substrate binding site [chemical binding]; other site
1114965002449	metal binding site [ion binding]; metal-binding site
1114965002450	GTPase CgtA; Reviewed; Region: obgE; PRK12297
1114965002451	GTP1/OBG; Region: GTP1_OBG; pfam01018
1114965002452	Obg GTPase; Region: Obg; cd01898
1114965002453	G1 box; other site
1114965002454	GTP/Mg2+ binding site [chemical binding]; other site
1114965002455	Switch I region; other site
1114965002456	G2 box; other site
1114965002457	G3 box; other site
1114965002458	Switch II region; other site
1114965002459	G4 box; other site
1114965002460	G5 box; other site
1114965002461	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
1114965002462	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1114965002463	homotrimer interaction site [polypeptide binding]; other site
1114965002464	putative active site [active]
1114965002465	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
1114965002466	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
1114965002467	Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044
1114965002468	dimer interface [polypeptide binding]; other site
1114965002469	phosphate binding site [ion binding]; other site
1114965002470	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
1114965002471	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
1114965002472	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
1114965002473	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1114965002474	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1114965002475	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
1114965002476	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
1114965002477	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
1114965002478	DNA primase; Validated; Region: dnaG; PRK05667
1114965002479	CHC2 zinc finger; Region: zf-CHC2; pfam01807
1114965002480	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1114965002481	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1114965002482	active site
1114965002483	metal binding site [ion binding]; metal-binding site
1114965002484	interdomain interaction site; other site
1114965002485	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
1114965002486	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
1114965002487	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1114965002488	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1114965002489	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1114965002490	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1114965002491	DNA binding residues [nucleotide binding]
1114965002492	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
1114965002493	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1114965002494	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1114965002495	Walker A/P-loop; other site
1114965002496	ATP binding site [chemical binding]; other site
1114965002497	Q-loop/lid; other site
1114965002498	ABC transporter signature motif; other site
1114965002499	Walker B; other site
1114965002500	D-loop; other site
1114965002501	H-loop/switch region; other site
1114965002502	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279
1114965002503	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
1114965002504	active site
1114965002505	PHP Thumb interface [polypeptide binding]; other site
1114965002506	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1114965002507	generic binding surface I; other site
1114965002508	generic binding surface II; other site
1114965002509	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
1114965002510	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
1114965002511	active site
1114965002512	ADP/pyrophosphate binding site [chemical binding]; other site
1114965002513	dimerization interface [polypeptide binding]; other site
1114965002514	allosteric effector site; other site
1114965002515	fructose-1,6-bisphosphate binding site; other site
1114965002516	pyruvate kinase; Provisional; Region: PRK05826
1114965002517	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1114965002518	domain interfaces; other site
1114965002519	active site
1114965002520	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1114965002521	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1114965002522	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1114965002523	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1114965002524	dimer interface [polypeptide binding]; other site
1114965002525	conserved gate region; other site
1114965002526	putative PBP binding loops; other site
1114965002527	ABC-ATPase subunit interface; other site
1114965002528	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1114965002529	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1114965002530	Walker A/P-loop; other site
1114965002531	ATP binding site [chemical binding]; other site
1114965002532	Q-loop/lid; other site
1114965002533	ABC transporter signature motif; other site
1114965002534	Walker B; other site
1114965002535	D-loop; other site
1114965002536	H-loop/switch region; other site
1114965002537	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1114965002538	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1114965002539	substrate binding pocket [chemical binding]; other site
1114965002540	membrane-bound complex binding site; other site
1114965002541	hinge residues; other site
1114965002542	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1114965002543	Cation efflux family; Region: Cation_efflux; pfam01545
1114965002544	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
1114965002545	Part of AAA domain; Region: AAA_19; pfam13245
1114965002546	Family description; Region: UvrD_C_2; pfam13538
1114965002547	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487
1114965002548	Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903
1114965002549	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1114965002550	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1114965002551	Coenzyme A binding pocket [chemical binding]; other site
1114965002552	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1114965002553	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251
1114965002554	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1114965002555	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1114965002556	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1114965002557	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484
1114965002558	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
1114965002559	RNA binding site [nucleotide binding]; other site
1114965002560	active site
1114965002561	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
1114965002562	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1114965002563	active site
1114965002564	Riboflavin kinase; Region: Flavokinase; smart00904
1114965002565	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
1114965002566	ArsC family; Region: ArsC; pfam03960
1114965002567	putative catalytic residues [active]
1114965002568	thiol/disulfide switch; other site
1114965002569	hypothetical protein; Provisional; Region: PRK04387
1114965002570	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1114965002571	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
1114965002572	active site
1114965002573	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
1114965002574	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1114965002575	S-adenosylmethionine binding site [chemical binding]; other site
1114965002576	Uncharacterized conserved protein [Function unknown]; Region: COG3270
1114965002577	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
1114965002578	PBP superfamily domain; Region: PBP_like_2; cl17296
1114965002579	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
1114965002580	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
1114965002581	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1114965002582	dimer interface [polypeptide binding]; other site
1114965002583	conserved gate region; other site
1114965002584	putative PBP binding loops; other site
1114965002585	ABC-ATPase subunit interface; other site
1114965002586	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
1114965002587	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1114965002588	dimer interface [polypeptide binding]; other site
1114965002589	conserved gate region; other site
1114965002590	putative PBP binding loops; other site
1114965002591	ABC-ATPase subunit interface; other site
1114965002592	phosphate transporter ATP-binding protein; Provisional; Region: PRK14237
1114965002593	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1114965002594	Walker A/P-loop; other site
1114965002595	ATP binding site [chemical binding]; other site
1114965002596	Q-loop/lid; other site
1114965002597	ABC transporter signature motif; other site
1114965002598	Walker B; other site
1114965002599	D-loop; other site
1114965002600	H-loop/switch region; other site
1114965002601	phosphate transporter ATP-binding protein; Provisional; Region: PRK14239
1114965002602	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1114965002603	Walker A/P-loop; other site
1114965002604	ATP binding site [chemical binding]; other site
1114965002605	Q-loop/lid; other site
1114965002606	ABC transporter signature motif; other site
1114965002607	Walker B; other site
1114965002608	D-loop; other site
1114965002609	H-loop/switch region; other site
1114965002610	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
1114965002611	PhoU domain; Region: PhoU; pfam01895
1114965002612	PhoU domain; Region: PhoU; pfam01895
1114965002613	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
1114965002614	Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601
1114965002615	Zn binding site [ion binding]; other site
1114965002616	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
1114965002617	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1114965002618	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1114965002619	active site
1114965002620	phosphorylation site [posttranslational modification]
1114965002621	intermolecular recognition site; other site
1114965002622	dimerization interface [polypeptide binding]; other site
1114965002623	LytTr DNA-binding domain; Region: LytTR; smart00850
1114965002624	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1114965002625	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1114965002626	Walker A/P-loop; other site
1114965002627	ATP binding site [chemical binding]; other site
1114965002628	Q-loop/lid; other site
1114965002629	ABC transporter signature motif; other site
1114965002630	Walker B; other site
1114965002631	D-loop; other site
1114965002632	H-loop/switch region; other site
1114965002633	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1114965002634	BioY family; Region: BioY; pfam02632
1114965002635	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1114965002636	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1114965002637	active site
1114965002638	phosphorylation site [posttranslational modification]
1114965002639	intermolecular recognition site; other site
1114965002640	dimerization interface [polypeptide binding]; other site
1114965002641	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1114965002642	DNA binding site [nucleotide binding]
1114965002643	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1114965002644	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1114965002645	dimer interface [polypeptide binding]; other site
1114965002646	phosphorylation site [posttranslational modification]
1114965002647	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1114965002648	ATP binding site [chemical binding]; other site
1114965002649	Mg2+ binding site [ion binding]; other site
1114965002650	G-X-G motif; other site
1114965002651	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1114965002652	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
1114965002653	dimer interface [polypeptide binding]; other site
1114965002654	active site
1114965002655	metal binding site [ion binding]; metal-binding site
1114965002656	glutathione binding site [chemical binding]; other site
1114965002657	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1114965002658	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
1114965002659	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1114965002660	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1114965002661	ATP binding site [chemical binding]; other site
1114965002662	putative Mg++ binding site [ion binding]; other site
1114965002663	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1114965002664	nucleotide binding region [chemical binding]; other site
1114965002665	ATP-binding site [chemical binding]; other site
1114965002666	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1114965002667	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1114965002668	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1114965002669	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
1114965002670	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1114965002671	Ligand binding site; other site
1114965002672	Putative Catalytic site; other site
1114965002673	DXD motif; other site
1114965002674	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
1114965002675	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
1114965002676	NADP binding site [chemical binding]; other site
1114965002677	active site
1114965002678	putative substrate binding site [chemical binding]; other site
1114965002679	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1114965002680	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1114965002681	active site
1114965002682	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
1114965002683	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
1114965002684	Ligand binding site; other site
1114965002685	Putative Catalytic site; other site
1114965002686	DXD motif; other site
1114965002687	Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034
1114965002688	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1114965002689	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1114965002690	active site
1114965002691	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1114965002692	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955
1114965002693	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1114965002694	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
1114965002695	Probable Catalytic site; other site
1114965002696	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
1114965002697	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1114965002698	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
1114965002699	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
1114965002700	Walker A/P-loop; other site
1114965002701	ATP binding site [chemical binding]; other site
1114965002702	Q-loop/lid; other site
1114965002703	ABC transporter signature motif; other site
1114965002704	Walker B; other site
1114965002705	D-loop; other site
1114965002706	H-loop/switch region; other site
1114965002707	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1114965002708	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1114965002709	active site
1114965002710	Rhamnan synthesis protein F; Region: RgpF; pfam05045
1114965002711	Predicted membrane protein (DUF2142); Region: DUF2142; pfam09913
1114965002712	Sulfatase; Region: Sulfatase; pfam00884
1114965002713	cytidylate kinase; Provisional; Region: cmk; PRK00023
1114965002714	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
1114965002715	CMP-binding site; other site
1114965002716	The sites determining sugar specificity; other site
1114965002717	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
1114965002718	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
1114965002719	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1114965002720	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
1114965002721	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
1114965002722	23S rRNA binding site [nucleotide binding]; other site
1114965002723	L21 binding site [polypeptide binding]; other site
1114965002724	L13 binding site [polypeptide binding]; other site
1114965002725	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
1114965002726	catalytic motif [active]
1114965002727	Zn binding site [ion binding]; other site
1114965002728	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1114965002729	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1114965002730	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1114965002731	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1114965002732	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1114965002733	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1114965002734	hinge; other site
1114965002735	active site
1114965002736	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1114965002737	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1114965002738	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
1114965002739	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1114965002740	DNA-binding site [nucleotide binding]; DNA binding site
1114965002741	DRTGG domain; Region: DRTGG; pfam07085
1114965002742	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
1114965002743	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
1114965002744	active site 2 [active]
1114965002745	active site 1 [active]
1114965002746	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1114965002747	active site
1114965002748	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
1114965002749	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1114965002750	MarR family; Region: MarR; pfam01047
1114965002751	Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382
1114965002752	B3/4 domain; Region: B3_4; pfam03483
1114965002753	Predicted membrane protein [Function unknown]; Region: COG2246
1114965002754	GtrA-like protein; Region: GtrA; pfam04138
1114965002755	Predicted membrane protein [Function unknown]; Region: COG4708
1114965002756	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1114965002757	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1114965002758	nucleotide binding pocket [chemical binding]; other site
1114965002759	K-X-D-G motif; other site
1114965002760	catalytic site [active]
1114965002761	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1114965002762	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
1114965002763	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1114965002764	Dimer interface [polypeptide binding]; other site
1114965002765	BRCT sequence motif; other site
1114965002766	putative lipid kinase; Reviewed; Region: PRK13055
1114965002767	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
1114965002768	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
1114965002769	carbohydrate binding site [chemical binding]; other site
1114965002770	pullulanase, type I; Region: pulA_typeI; TIGR02104
1114965002771	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
1114965002772	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
1114965002773	Ca binding site [ion binding]; other site
1114965002774	active site
1114965002775	catalytic site [active]
1114965002776	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
1114965002777	Sulfatase; Region: Sulfatase; pfam00884
1114965002778	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
1114965002779	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
1114965002780	putative RNA binding site [nucleotide binding]; other site
1114965002781	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1114965002782	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
1114965002783	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
1114965002784	active site
1114965002785	catalytic residue [active]
1114965002786	dimer interface [polypeptide binding]; other site
1114965002787	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
1114965002788	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1114965002789	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1114965002790	NAD(P) binding site [chemical binding]; other site
1114965002791	shikimate binding site; other site
1114965002792	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
1114965002793	active site
1114965002794	dimer interface [polypeptide binding]; other site
1114965002795	metal binding site [ion binding]; metal-binding site
1114965002796	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
1114965002797	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1114965002798	Tetramer interface [polypeptide binding]; other site
1114965002799	active site
1114965002800	FMN-binding site [chemical binding]; other site
1114965002801	prephenate dehydrogenase; Validated; Region: PRK06545
1114965002802	prephenate dehydrogenase; Validated; Region: PRK08507
1114965002803	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
1114965002804	hypothetical protein; Provisional; Region: PRK13676
1114965002805	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1114965002806	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1114965002807	putative substrate translocation pore; other site
1114965002808	shikimate 5-dehydrogenase; Provisional; Region: PRK12548
1114965002809	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1114965002810	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1114965002811	shikimate binding site; other site
1114965002812	NAD(P) binding site [chemical binding]; other site
1114965002813	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1114965002814	putative substrate translocation pore; other site
1114965002815	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1114965002816	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
1114965002817	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
1114965002818	active site
1114965002819	catalytic residue [active]
1114965002820	dimer interface [polypeptide binding]; other site
1114965002821	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1114965002822	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
1114965002823	putative active site [active]
1114965002824	putative FMN binding site [chemical binding]; other site
1114965002825	putative substrate binding site [chemical binding]; other site
1114965002826	putative catalytic residue [active]
1114965002827	FMN-binding domain; Region: FMN_bind; pfam04205
1114965002828	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
1114965002829	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
1114965002830	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
1114965002831	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1114965002832	hinge; other site
1114965002833	active site
1114965002834	shikimate kinase; Reviewed; Region: aroK; PRK00131
1114965002835	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1114965002836	ADP binding site [chemical binding]; other site
1114965002837	magnesium binding site [ion binding]; other site
1114965002838	putative shikimate binding site; other site
1114965002839	prephenate dehydratase; Provisional; Region: PRK11898
1114965002840	Prephenate dehydratase; Region: PDT; pfam00800
1114965002841	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
1114965002842	putative L-Phe binding site [chemical binding]; other site
1114965002843	Transcriptional regulator [Transcription]; Region: LytR; COG1316
1114965002844	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
1114965002845	TRAM domain; Region: TRAM; cl01282
1114965002846	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1114965002847	S-adenosylmethionine binding site [chemical binding]; other site
1114965002848	potential frameshift: common BLAST hit: gi|126699459|ref|YP_001088356.1| AraC family transcription regulator
1114965002849	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1114965002850	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1114965002851	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
1114965002852	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1114965002853	conserved cys residue [active]
1114965002854	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1114965002855	Phosphotransferase enzyme family; Region: APH; pfam01636
1114965002856	active site
1114965002857	substrate binding site [chemical binding]; other site
1114965002858	ATP binding site [chemical binding]; other site
1114965002859	HEAT repeats; Region: HEAT_2; pfam13646
1114965002860	DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335
1114965002861	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1114965002862	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1114965002863	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1114965002864	ATP binding site [chemical binding]; other site
1114965002865	Q-loop/lid; other site
1114965002866	ABC transporter signature motif; other site
1114965002867	Walker B; other site
1114965002868	D-loop; other site
1114965002869	H-loop/switch region; other site
1114965002870	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1114965002871	ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397
1114965002872	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
1114965002873	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
1114965002874	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1114965002875	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1114965002876	Walker A/P-loop; other site
1114965002877	ATP binding site [chemical binding]; other site
1114965002878	Q-loop/lid; other site
1114965002879	ABC transporter signature motif; other site
1114965002880	Walker B; other site
1114965002881	D-loop; other site
1114965002882	H-loop/switch region; other site
1114965002883	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
1114965002884	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1114965002885	DNA binding residues [nucleotide binding]
1114965002886	dimer interface [polypeptide binding]; other site
1114965002887	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
1114965002888	CAAX protease self-immunity; Region: Abi; pfam02517
1114965002889	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1114965002890	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1114965002891	non-specific DNA binding site [nucleotide binding]; other site
1114965002892	salt bridge; other site
1114965002893	sequence-specific DNA binding site [nucleotide binding]; other site
1114965002894	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1114965002895	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1114965002896	non-specific DNA binding site [nucleotide binding]; other site
1114965002897	salt bridge; other site
1114965002898	sequence-specific DNA binding site [nucleotide binding]; other site
1114965002899	Protein of unknown function (DUF3278); Region: DUF3278; pfam11683
1114965002900	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
1114965002901	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626
1114965002902	Fic/DOC family; Region: Fic; pfam02661
1114965002903	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
1114965002904	homodimer interface [polypeptide binding]; other site
1114965002905	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
1114965002906	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1114965002907	active site
1114965002908	homodimer interface [polypeptide binding]; other site
1114965002909	catalytic site [active]
1114965002910	RDD family; Region: RDD; cl00746
1114965002911	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
1114965002912	putative active site [active]
1114965002913	nucleotide binding site [chemical binding]; other site
1114965002914	nudix motif; other site
1114965002915	putative metal binding site [ion binding]; other site
1114965002916	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1114965002917	Helix-Turn-Helix DNA binding domain of MerR-like transcription regulators; Region: HTH_MerR-like; cd00592
1114965002918	DNA binding residues [nucleotide binding]
1114965002919	dimer interface [polypeptide binding]; other site
1114965002920	Domain of unknown function (DUF4300); Region: DUF4300; pfam14133
1114965002921	Uncharacterized protein family (UPF0167); Region: UPF0167; cl01252
1114965002922	CAAX protease self-immunity; Region: Abi; pfam02517
1114965002923	CAAX protease self-immunity; Region: Abi; cl00558
1114965002924	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1114965002925	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1114965002926	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
1114965002927	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
1114965002928	glycerol kinase; Provisional; Region: glpK; PRK00047
1114965002929	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
1114965002930	N- and C-terminal domain interface [polypeptide binding]; other site
1114965002931	active site
1114965002932	MgATP binding site [chemical binding]; other site
1114965002933	catalytic site [active]
1114965002934	metal binding site [ion binding]; metal-binding site
1114965002935	glycerol binding site [chemical binding]; other site
1114965002936	homotetramer interface [polypeptide binding]; other site
1114965002937	homodimer interface [polypeptide binding]; other site
1114965002938	FBP binding site [chemical binding]; other site
1114965002939	protein IIAGlc interface [polypeptide binding]; other site
1114965002940	acetoin reductase; Validated; Region: PRK08643
1114965002941	meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366
1114965002942	NAD binding site [chemical binding]; other site
1114965002943	homotetramer interface [polypeptide binding]; other site
1114965002944	homodimer interface [polypeptide binding]; other site
1114965002945	active site
1114965002946	substrate binding site [chemical binding]; other site
1114965002947	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
1114965002948	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
1114965002949	DHH family; Region: DHH; pfam01368
1114965002950	DHHA1 domain; Region: DHHA1; pfam02272
1114965002951	type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197
1114965002952	LXG domain of WXG superfamily; Region: LXG; pfam04740
1114965002953	Protein of unknown function (DUF3114); Region: DUF3114; pfam11311
1114965002954	flavodoxin; Validated; Region: PRK07308
1114965002955	hypothetical protein; Provisional; Region: PRK07248
1114965002956	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1114965002957	ClC sycA-like chloride channel proteins. This ClC family presents in bacteria, where it facilitates acid resistance in acidic soil. Mutation of this gene (sycA) in Rhizobium tropici CIAT899 causes serious deficiencies in nodule development, nodulation...; Region: ClC_sycA_like; cd03682
1114965002958	putative Cl- selectivity filter; other site
1114965002959	putative pore gating glutamate residue; other site
1114965002960	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
1114965002961	Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339
1114965002962	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
1114965002963	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
1114965002964	trmE is a tRNA modification GTPase; Region: trmE; cd04164
1114965002965	G1 box; other site
1114965002966	GTP/Mg2+ binding site [chemical binding]; other site
1114965002967	Switch I region; other site
1114965002968	G2 box; other site
1114965002969	Switch II region; other site
1114965002970	G3 box; other site
1114965002971	G4 box; other site
1114965002972	G5 box; other site
1114965002973	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
1114965002974	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
1114965002975	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1114965002976	active site
1114965002977	dimer interface [polypeptide binding]; other site
1114965002978	phosphopentomutase; Provisional; Region: PRK05362
1114965002979	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
1114965002980	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797
1114965002981	purine nucleoside phosphorylase; Provisional; Region: PRK08202
1114965002982	Putative ClC chloride channel.  Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033
1114965002983	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1114965002984	putative ion selectivity filter; other site
1114965002985	putative pore gating glutamate residue; other site
1114965002986	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
1114965002987	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
1114965002988	catalytic triad [active]
1114965002989	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
1114965002990	CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl09873
1114965002991	NAD-dependent deacetylase; Provisional; Region: PRK00481
1114965002992	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
1114965002993	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1114965002994	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1114965002995	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1114965002996	dimerization interface [polypeptide binding]; other site
1114965002997	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
1114965002998	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
1114965002999	FAD binding pocket [chemical binding]; other site
1114965003000	FAD binding motif [chemical binding]; other site
1114965003001	phosphate binding motif [ion binding]; other site
1114965003002	beta-alpha-beta structure motif; other site
1114965003003	NAD binding pocket [chemical binding]; other site
1114965003004	Iron coordination center [ion binding]; other site
1114965003005	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
1114965003006	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
1114965003007	heterodimer interface [polypeptide binding]; other site
1114965003008	active site
1114965003009	FMN binding site [chemical binding]; other site
1114965003010	homodimer interface [polypeptide binding]; other site
1114965003011	substrate binding site [chemical binding]; other site
1114965003012	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
1114965003013	active site
1114965003014	dimer interface [polypeptide binding]; other site
1114965003015	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1114965003016	active site
1114965003017	conserved hypothetical integral membrane protein; Region: TIGR03766
1114965003018	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
1114965003019	ligand binding site [chemical binding]; other site
1114965003020	active site
1114965003021	UGI interface [polypeptide binding]; other site
1114965003022	catalytic site [active]
1114965003023	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
1114965003024	putative active site [active]
1114965003025	nucleotide binding site [chemical binding]; other site
1114965003026	nudix motif; other site
1114965003027	putative metal binding site [ion binding]; other site
1114965003028	dihydroorotase; Validated; Region: pyrC; PRK09357
1114965003029	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1114965003030	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
1114965003031	active site
1114965003032	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506
1114965003033	active site
1114965003034	catalytic triad [active]
1114965003035	oxyanion hole [active]
1114965003036	Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548
1114965003037	2-isopropylmalate synthase; Validated; Region: PRK00915
1114965003038	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
1114965003039	active site
1114965003040	catalytic residues [active]
1114965003041	metal binding site [ion binding]; metal-binding site
1114965003042	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
1114965003043	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
1114965003044	tartrate dehydrogenase; Region: TTC; TIGR02089
1114965003045	Protein of unknown function (DUF1294); Region: DUF1294; cl01311
1114965003046	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
1114965003047	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
1114965003048	substrate binding site [chemical binding]; other site
1114965003049	ligand binding site [chemical binding]; other site
1114965003050	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
1114965003051	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
1114965003052	substrate binding site [chemical binding]; other site
1114965003053	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
1114965003054	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
1114965003055	DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058
1114965003056	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1114965003057	Mg2+ binding site [ion binding]; other site
1114965003058	G-X-G motif; other site
1114965003059	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1114965003060	anchoring element; other site
1114965003061	dimer interface [polypeptide binding]; other site
1114965003062	ATP binding site [chemical binding]; other site
1114965003063	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1114965003064	active site
1114965003065	putative metal-binding site [ion binding]; other site
1114965003066	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1114965003067	Streptomycin adenylyltransferase; Region: Adenyl_transf; pfam04439
1114965003068	DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061
1114965003069	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1114965003070	CAP-like domain; other site
1114965003071	active site
1114965003072	primary dimer interface [polypeptide binding]; other site
1114965003073	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1114965003074	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
1114965003075	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
1114965003076	homodimer interface [polypeptide binding]; other site
1114965003077	substrate-cofactor binding pocket; other site
1114965003078	catalytic residue [active]
1114965003079	Protein of unknown function (DUF2969); Region: DUF2969; pfam11184
1114965003080	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
1114965003081	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
1114965003082	RNA binding site [nucleotide binding]; other site
1114965003083	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1114965003084	RNA binding site [nucleotide binding]; other site
1114965003085	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
1114965003086	RNA binding site [nucleotide binding]; other site
1114965003087	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
1114965003088	RNA binding site [nucleotide binding]; other site
1114965003089	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
1114965003090	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
1114965003091	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1114965003092	NAD binding site [chemical binding]; other site
1114965003093	dimer interface [polypeptide binding]; other site
1114965003094	substrate binding site [chemical binding]; other site
1114965003095	DNA gyrase subunit A; Validated; Region: PRK05560
1114965003096	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1114965003097	CAP-like domain; other site
1114965003098	active site
1114965003099	primary dimer interface [polypeptide binding]; other site
1114965003100	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1114965003101	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1114965003102	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1114965003103	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1114965003104	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1114965003105	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1114965003106	Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165
1114965003107	active site
1114965003108	catalytic site [active]
1114965003109	hypothetical protein; Reviewed; Region: PRK00024
1114965003110	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
1114965003111	MPN+ (JAMM) motif; other site
1114965003112	Zinc-binding site [ion binding]; other site
1114965003113	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1114965003114	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1114965003115	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1114965003116	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
1114965003117	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
1114965003118	CoA binding domain; Region: CoA_binding; pfam02629
1114965003119	Putative amino acid metabolism; Region: DUF1831; pfam08866
1114965003120	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1114965003121	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1114965003122	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1114965003123	catalytic residue [active]
1114965003124	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458
1114965003125	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1114965003126	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1114965003127	active site
1114965003128	Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762
1114965003129	putative active site [active]
1114965003130	putative metal binding residues [ion binding]; other site
1114965003131	signature motif; other site
1114965003132	putative triphosphate binding site [ion binding]; other site
1114965003133	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1114965003134	synthetase active site [active]
1114965003135	NTP binding site [chemical binding]; other site
1114965003136	metal binding site [ion binding]; metal-binding site
1114965003137	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
1114965003138	ATP-NAD kinase; Region: NAD_kinase; pfam01513
1114965003139	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1114965003140	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1114965003141	active site
1114965003142	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
1114965003143	HTH-like domain; Region: HTH_21; pfam13276
1114965003144	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
1114965003145	Integrase core domain; Region: rve; pfam00665
1114965003146	Integrase core domain; Region: rve_2; pfam13333
1114965003147	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1114965003148	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1114965003149	dimerization interface [polypeptide binding]; other site
1114965003150	putative Zn2+ binding site [ion binding]; other site
1114965003151	putative DNA binding site [nucleotide binding]; other site
1114965003152	Transposase; Region: HTH_Tnp_1; cl17663
1114965003153	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
1114965003154	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1114965003155	minor groove reading motif; other site
1114965003156	helix-hairpin-helix signature motif; other site
1114965003157	substrate binding pocket [chemical binding]; other site
1114965003158	active site
1114965003159	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
1114965003160	DNA binding and oxoG recognition site [nucleotide binding]
1114965003161	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1114965003162	catalytic residues [active]
1114965003163	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
1114965003164	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
1114965003165	active site
1114965003166	substrate binding site [chemical binding]; other site
1114965003167	metal binding site [ion binding]; metal-binding site
1114965003168	Predicted membrane protein [Function unknown]; Region: COG4684
1114965003169	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
1114965003170	phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313
1114965003171	Flavoprotein; Region: Flavoprotein; pfam02441
1114965003172	phosphopantothenate--cysteine ligase; Validated; Region: PRK06732
1114965003173	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
1114965003174	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
1114965003175	Potassium binding sites [ion binding]; other site
1114965003176	Cesium cation binding sites [ion binding]; other site
1114965003177	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1114965003178	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
1114965003179	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
1114965003180	Uncharacterized conserved protein [Function unknown]; Region: COG1434
1114965003181	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
1114965003182	putative active site [active]
1114965003183	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
1114965003184	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1114965003185	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
1114965003186	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1114965003187	catalytic residues [active]
1114965003188	Predicted flavoprotein [General function prediction only]; Region: COG0431
1114965003189	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1114965003190	PAS domain; Region: PAS_10; pfam13596
1114965003191	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1114965003192	Predicted flavoprotein [General function prediction only]; Region: COG0431
1114965003193	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
1114965003194	ApbE family; Region: ApbE; pfam02424
1114965003195	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
1114965003196	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1114965003197	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1114965003198	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
1114965003199	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1114965003200	Cl- selectivity filter; other site
1114965003201	Cl- binding residues [ion binding]; other site
1114965003202	pore gating glutamate residue; other site
1114965003203	dimer interface [polypeptide binding]; other site
1114965003204	H+/Cl- coupling transport residue; other site
1114965003205	TrkA-C domain; Region: TrkA_C; pfam02080
1114965003206	Imelysin; Region: Peptidase_M75; pfam09375
1114965003207	Tat-translocated enzyme; Region: tat_substr_1; TIGR01412
1114965003208	Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837
1114965003209	Iron permease FTR1 family; Region: FTR1; cl00475
1114965003210	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
1114965003211	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
1114965003212	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1114965003213	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
1114965003214	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
1114965003215	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1114965003216	active site
1114965003217	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1114965003218	active site
1114965003219	xanthine permease; Region: pbuX; TIGR03173
1114965003220	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1114965003221	multidrug efflux protein; Reviewed; Region: PRK01766
1114965003222	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
1114965003223	cation binding site [ion binding]; other site
1114965003224	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
1114965003225	4-oxalocrotonate tautomerase; Provisional; Region: PRK02289
1114965003226	active site 1 [active]
1114965003227	dimer interface [polypeptide binding]; other site
1114965003228	hexamer interface [polypeptide binding]; other site
1114965003229	active site 2 [active]
1114965003230	thymidine kinase; Provisional; Region: PRK04296
1114965003231	peptide chain release factor 1; Validated; Region: prfA; PRK00591
1114965003232	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1114965003233	RF-1 domain; Region: RF-1; pfam00472
1114965003234	protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534
1114965003235	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1114965003236	S-adenosylmethionine binding site [chemical binding]; other site
1114965003237	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
1114965003238	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1114965003239	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1114965003240	dimer interface [polypeptide binding]; other site
1114965003241	active site
1114965003242	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1114965003243	folate binding site [chemical binding]; other site
1114965003244	37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473
1114965003245	Lysozyme-like; Region: Lysozyme_like; pfam13702
1114965003246	catalytic residue [active]
1114965003247	Predicted secreted protein [Function unknown]; Region: COG4086
1114965003248	Protein of unknown function (DUF1002); Region: DUF1002; pfam06207
1114965003249	GMP synthase; Reviewed; Region: guaA; PRK00074
1114965003250	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1114965003251	AMP/PPi binding site [chemical binding]; other site
1114965003252	candidate oxyanion hole; other site
1114965003253	catalytic triad [active]
1114965003254	potential glutamine specificity residues [chemical binding]; other site
1114965003255	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1114965003256	ATP Binding subdomain [chemical binding]; other site
1114965003257	Dimerization subdomain; other site
1114965003258	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1114965003259	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1114965003260	DNA-binding site [nucleotide binding]; DNA binding site
1114965003261	UTRA domain; Region: UTRA; pfam07702
1114965003262	Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819
1114965003263	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1114965003264	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1114965003265	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1114965003266	NAD(P) binding site [chemical binding]; other site
1114965003267	active site
1114965003268	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1114965003269	putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304
1114965003270	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
1114965003271	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204
1114965003272	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1114965003273	dimer interface [polypeptide binding]; other site
1114965003274	active site
1114965003275	CoA binding pocket [chemical binding]; other site
1114965003276	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
1114965003277	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
1114965003278	signal recognition particle protein; Provisional; Region: PRK10867
1114965003279	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1114965003280	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1114965003281	P loop; other site
1114965003282	GTP binding site [chemical binding]; other site
1114965003283	Signal peptide binding domain; Region: SRP_SPB; pfam02978
1114965003284	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
1114965003285	Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448
1114965003286	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626
1114965003287	site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084
1114965003288	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1114965003289	active site
1114965003290	DNA binding site [nucleotide binding]
1114965003291	Int/Topo IB signature motif; other site
1114965003292	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1114965003293	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
1114965003294	Walker A/P-loop; other site
1114965003295	ATP binding site [chemical binding]; other site
1114965003296	Q-loop/lid; other site
1114965003297	ABC transporter signature motif; other site
1114965003298	Walker B; other site
1114965003299	D-loop; other site
1114965003300	H-loop/switch region; other site
1114965003301	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652
1114965003302	Protein of unknown function (DUF1430); Region: DUF1430; pfam07242
1114965003303	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
1114965003304	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
1114965003305	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
1114965003306	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1114965003307	E3 interaction surface; other site
1114965003308	lipoyl attachment site [posttranslational modification]; other site
1114965003309	dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350
1114965003310	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1114965003311	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1114965003312	dihydrolipoamide acetyltransferase; Provisional; Region: PRK14843
1114965003313	e3 binding domain; Region: E3_binding; pfam02817
1114965003314	e3 binding domain; Region: E3_binding; pfam02817
1114965003315	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1114965003316	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1114965003317	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1114965003318	alpha subunit interface [polypeptide binding]; other site
1114965003319	TPP binding site [chemical binding]; other site
1114965003320	heterodimer interface [polypeptide binding]; other site
1114965003321	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1114965003322	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
1114965003323	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1114965003324	tetramer interface [polypeptide binding]; other site
1114965003325	TPP-binding site [chemical binding]; other site
1114965003326	heterodimer interface [polypeptide binding]; other site
1114965003327	phosphorylation loop region [posttranslational modification]
1114965003328	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
1114965003329	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947
1114965003330	Putative esterase; Region: Esterase; pfam00756
1114965003331	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
1114965003332	Putative esterase; Region: Esterase; pfam00756
1114965003333	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
1114965003334	Glucose inhibited division protein A; Region: GIDA; pfam01134
1114965003335	Protein of unknown function (DUF3307); Region: DUF3307; pfam11750
1114965003336	DNA topoisomerase I; Validated; Region: PRK05582
1114965003337	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
1114965003338	active site
1114965003339	interdomain interaction site; other site
1114965003340	putative metal-binding site [ion binding]; other site
1114965003341	nucleotide binding site [chemical binding]; other site
1114965003342	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1114965003343	domain I; other site
1114965003344	DNA binding groove [nucleotide binding]
1114965003345	phosphate binding site [ion binding]; other site
1114965003346	domain II; other site
1114965003347	domain III; other site
1114965003348	nucleotide binding site [chemical binding]; other site
1114965003349	catalytic site [active]
1114965003350	domain IV; other site
1114965003351	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1114965003352	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1114965003353	DNA protecting protein DprA; Region: dprA; TIGR00732
1114965003354	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
1114965003355	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1114965003356	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1114965003357	nucleotide binding site [chemical binding]; other site
1114965003358	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1114965003359	RNA/DNA hybrid binding site [nucleotide binding]; other site
1114965003360	active site
1114965003361	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
1114965003362	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
1114965003363	GTP/Mg2+ binding site [chemical binding]; other site
1114965003364	G4 box; other site
1114965003365	G5 box; other site
1114965003366	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
1114965003367	G1 box; other site
1114965003368	G1 box; other site
1114965003369	GTP/Mg2+ binding site [chemical binding]; other site
1114965003370	Switch I region; other site
1114965003371	G2 box; other site
1114965003372	G2 box; other site
1114965003373	G3 box; other site
1114965003374	G3 box; other site
1114965003375	Switch II region; other site
1114965003376	Switch II region; other site
1114965003377	G4 box; other site
1114965003378	ATP cone domain; Region: ATP-cone; pfam03477
1114965003379	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1114965003380	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1114965003381	dimer interface [polypeptide binding]; other site
1114965003382	active site
1114965003383	catalytic residue [active]
1114965003384	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
1114965003385	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1114965003386	LemA family; Region: LemA; cl00742
1114965003387	Protein of unknown function (DUF3137); Region: DUF3137; pfam11335
1114965003388	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
1114965003389	A new structural DNA glycosylase containing HEAT-like repeats; Region: AlkD_like_1; cd07064
1114965003390	active site
1114965003391	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
1114965003392	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
1114965003393	Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154
1114965003394	putative active site [active]
1114965003395	catalytic site [active]
1114965003396	Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160
1114965003397	putative active site [active]
1114965003398	catalytic site [active]
1114965003399	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
1114965003400	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1114965003401	Coenzyme A binding pocket [chemical binding]; other site
1114965003402	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1114965003403	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1114965003404	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1114965003405	Walker A/P-loop; other site
1114965003406	ATP binding site [chemical binding]; other site
1114965003407	Q-loop/lid; other site
1114965003408	ABC transporter signature motif; other site
1114965003409	Walker B; other site
1114965003410	D-loop; other site
1114965003411	H-loop/switch region; other site
1114965003412	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1114965003413	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1114965003414	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1114965003415	Walker A/P-loop; other site
1114965003416	ATP binding site [chemical binding]; other site
1114965003417	Q-loop/lid; other site
1114965003418	ABC transporter signature motif; other site
1114965003419	Walker B; other site
1114965003420	D-loop; other site
1114965003421	H-loop/switch region; other site
1114965003422	integron integrase; Region: integrase_gron; TIGR02249
1114965003423	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
1114965003424	Int/Topo IB signature motif; other site
1114965003425	Domain of unknown function (DUF3173); Region: DUF3173; pfam11372
1114965003426	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1114965003427	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1114965003428	sequence-specific DNA binding site [nucleotide binding]; other site
1114965003429	salt bridge; other site
1114965003430	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
1114965003431	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1114965003432	Walker A/P-loop; other site
1114965003433	ATP binding site [chemical binding]; other site
1114965003434	Q-loop/lid; other site
1114965003435	ABC transporter signature motif; other site
1114965003436	Walker B; other site
1114965003437	D-loop; other site
1114965003438	H-loop/switch region; other site
1114965003439	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1114965003440	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1114965003441	active site
1114965003442	phosphorylation site [posttranslational modification]
1114965003443	intermolecular recognition site; other site
1114965003444	dimerization interface [polypeptide binding]; other site
1114965003445	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1114965003446	DNA binding site [nucleotide binding]
1114965003447	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1114965003448	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1114965003449	dimer interface [polypeptide binding]; other site
1114965003450	phosphorylation site [posttranslational modification]
1114965003451	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1114965003452	ATP binding site [chemical binding]; other site
1114965003453	G-X-G motif; other site
1114965003454	Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843
1114965003455	Lantibiotic streptin immunity protein; Region: Streptin-Immun; pfam11083
1114965003456	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
1114965003457	P-loop containing region of AAA domain; Region: AAA_29; cl17516
1114965003458	AAA domain; Region: AAA_21; pfam13304
1114965003459	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1114965003460	ABC transporter signature motif; other site
1114965003461	Walker B; other site
1114965003462	D-loop; other site
1114965003463	H-loop/switch region; other site
1114965003464	Zeta toxin; Region: Zeta_toxin; pfam06414
1114965003465	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1114965003466	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1114965003467	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1114965003468	non-specific DNA binding site [nucleotide binding]; other site
1114965003469	salt bridge; other site
1114965003470	sequence-specific DNA binding site [nucleotide binding]; other site
1114965003471	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
1114965003472	Toprim-like; Region: Toprim_2; pfam13155
1114965003473	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200
1114965003474	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1114965003475	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1114965003476	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1114965003477	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
1114965003478	Walker A/P-loop; other site
1114965003479	ATP binding site [chemical binding]; other site
1114965003480	Q-loop/lid; other site
1114965003481	ABC transporter signature motif; other site
1114965003482	Walker B; other site
1114965003483	D-loop; other site
1114965003484	H-loop/switch region; other site
1114965003485	Type-A lantibiotic; Region: L_biotic_typeA; pfam04604
1114965003486	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1114965003487	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1114965003488	active site
1114965003489	phosphorylation site [posttranslational modification]
1114965003490	intermolecular recognition site; other site
1114965003491	dimerization interface [polypeptide binding]; other site
1114965003492	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1114965003493	DNA binding site [nucleotide binding]
1114965003494	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1114965003495	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1114965003496	dimer interface [polypeptide binding]; other site
1114965003497	phosphorylation site [posttranslational modification]
1114965003498	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1114965003499	ATP binding site [chemical binding]; other site
1114965003500	Mg2+ binding site [ion binding]; other site
1114965003501	G-X-G motif; other site
1114965003502	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1114965003503	S-adenosylmethionine binding site [chemical binding]; other site
1114965003504	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
1114965003505	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1114965003506	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
1114965003507	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
1114965003508	helicase superfamily c-terminal domain; Region: HELICc; smart00490
1114965003509	Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320
1114965003510	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1114965003511	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1114965003512	dimer interface [polypeptide binding]; other site
1114965003513	phosphorylation site [posttranslational modification]
1114965003514	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1114965003515	ATP binding site [chemical binding]; other site
1114965003516	Mg2+ binding site [ion binding]; other site
1114965003517	G-X-G motif; other site
1114965003518	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1114965003519	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1114965003520	active site
1114965003521	phosphorylation site [posttranslational modification]
1114965003522	intermolecular recognition site; other site
1114965003523	dimerization interface [polypeptide binding]; other site
1114965003524	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1114965003525	DNA binding site [nucleotide binding]
1114965003526	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1114965003527	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
1114965003528	Walker A/P-loop; other site
1114965003529	ATP binding site [chemical binding]; other site
1114965003530	Q-loop/lid; other site
1114965003531	ABC transporter signature motif; other site
1114965003532	Walker B; other site
1114965003533	D-loop; other site
1114965003534	H-loop/switch region; other site
1114965003535	Peptidase family M23; Region: Peptidase_M23; pfam01551
1114965003536	CHAP domain; Region: CHAP; pfam05257
1114965003537	AAA-like domain; Region: AAA_10; pfam12846
1114965003538	PrgI family protein; Region: PrgI; pfam12666
1114965003539	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
1114965003540	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
1114965003541	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1114965003542	Walker A motif; other site
1114965003543	ATP binding site [chemical binding]; other site
1114965003544	Walker B motif; other site
1114965003545	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
1114965003546	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
1114965003547	CAAX protease self-immunity; Region: Abi; pfam02517
1114965003548	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1114965003549	cofactor binding site; other site
1114965003550	DNA binding site [nucleotide binding]
1114965003551	substrate interaction site [chemical binding]; other site
1114965003552	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1114965003553	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
1114965003554	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
1114965003555	core dimer interface [polypeptide binding]; other site
1114965003556	L10 interface [polypeptide binding]; other site
1114965003557	L11 interface [polypeptide binding]; other site
1114965003558	putative EF-Tu interaction site [polypeptide binding]; other site
1114965003559	putative EF-G interaction site [polypeptide binding]; other site
1114965003560	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1114965003561	23S rRNA interface [nucleotide binding]; other site
1114965003562	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1114965003563	Formate/nitrite transporter; Region: Form_Nir_trans; cl00927
1114965003564	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
1114965003565	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
1114965003566	G1 box; other site
1114965003567	GTP/Mg2+ binding site [chemical binding]; other site
1114965003568	Switch I region; other site
1114965003569	G2 box; other site
1114965003570	G3 box; other site
1114965003571	Switch II region; other site
1114965003572	G4 box; other site
1114965003573	G5 box; other site
1114965003574	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
1114965003575	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
1114965003576	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1114965003577	Walker A motif; other site
1114965003578	ATP binding site [chemical binding]; other site
1114965003579	Walker B motif; other site
1114965003580	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1114965003581	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1114965003582	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
1114965003583	folate binding site [chemical binding]; other site
1114965003584	NADP+ binding site [chemical binding]; other site
1114965003585	thymidylate synthase; Reviewed; Region: thyA; PRK01827
1114965003586	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
1114965003587	dimerization interface [polypeptide binding]; other site
1114965003588	active site
1114965003589	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
1114965003590	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1114965003591	nucleotide binding site [chemical binding]; other site
1114965003592	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1114965003593	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1114965003594	Walker A/P-loop; other site
1114965003595	ATP binding site [chemical binding]; other site
1114965003596	Q-loop/lid; other site
1114965003597	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1114965003598	ABC transporter; Region: ABC_tran_2; pfam12848
1114965003599	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1114965003600	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
1114965003601	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1114965003602	active site
1114965003603	NTP binding site [chemical binding]; other site
1114965003604	metal binding triad [ion binding]; metal-binding site
1114965003605	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1114965003606	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
1114965003607	dihydrodipicolinate reductase; Provisional; Region: PRK00048
1114965003608	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1114965003609	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
1114965003610	EDD domain protein, DegV family; Region: DegV; TIGR00762
1114965003611	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1114965003612	Protein of unknown function (DUF1149); Region: DUF1149; pfam06619
1114965003613	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1114965003614	active site
1114965003615	phosphorylation site [posttranslational modification]
1114965003616	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
1114965003617	active site
1114965003618	P-loop; other site
1114965003619	phosphorylation site [posttranslational modification]
1114965003620	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
1114965003621	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
1114965003622	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1114965003623	putative substrate binding site [chemical binding]; other site
1114965003624	putative ATP binding site [chemical binding]; other site
1114965003625	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1114965003626	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1114965003627	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1114965003628	Cysteine-rich secretory protein family; Region: CAP; pfam00188
1114965003629	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
1114965003630	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
1114965003631	RimM N-terminal domain; Region: RimM; pfam01782
1114965003632	PRC-barrel domain; Region: PRC; pfam05239
1114965003633	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
1114965003634	KH domain; Region: KH_4; pfam13083
1114965003635	G-X-X-G motif; other site
1114965003636	Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228
1114965003637	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
1114965003638	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1114965003639	motif II; other site
1114965003640	Flagellin N-methylase; Region: FliB; pfam03692
1114965003641	GTP-binding protein LepA; Provisional; Region: PRK05433
1114965003642	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1114965003643	G1 box; other site
1114965003644	putative GEF interaction site [polypeptide binding]; other site
1114965003645	GTP/Mg2+ binding site [chemical binding]; other site
1114965003646	Switch I region; other site
1114965003647	G2 box; other site
1114965003648	G3 box; other site
1114965003649	Switch II region; other site
1114965003650	G4 box; other site
1114965003651	G5 box; other site
1114965003652	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
1114965003653	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1114965003654	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1114965003655	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1114965003656	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1114965003657	Coenzyme A binding pocket [chemical binding]; other site
1114965003658	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1114965003659	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1114965003660	non-specific DNA binding site [nucleotide binding]; other site
1114965003661	salt bridge; other site
1114965003662	sequence-specific DNA binding site [nucleotide binding]; other site
1114965003663	Predicted transcriptional regulator [Transcription]; Region: COG2932
1114965003664	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1114965003665	Catalytic site [active]
1114965003666	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1114965003667	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1114965003668	active site
1114965003669	motif I; other site
1114965003670	motif II; other site
1114965003671	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1114965003672	peptidase T; Region: peptidase-T; TIGR01882
1114965003673	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
1114965003674	metal binding site [ion binding]; metal-binding site
1114965003675	dimer interface [polypeptide binding]; other site
1114965003676	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1114965003677	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1114965003678	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1114965003679	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
1114965003680	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1114965003681	catalytic site [active]
1114965003682	subunit interface [polypeptide binding]; other site
1114965003683	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
1114965003684	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1114965003685	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1114965003686	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
1114965003687	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1114965003688	active site
1114965003689	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
1114965003690	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
1114965003691	PhnA protein; Region: PhnA; pfam03831
1114965003692	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
1114965003693	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1114965003694	motif II; other site
1114965003695	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1114965003696	Thioesterase-like superfamily; Region: 4HBT_3; pfam13622
1114965003697	CoenzymeA binding site [chemical binding]; other site
1114965003698	subunit interaction site [polypeptide binding]; other site
1114965003699	PHB binding site; other site
1114965003700	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
1114965003701	putative active site [active]
1114965003702	nucleotide binding site [chemical binding]; other site
1114965003703	nudix motif; other site
1114965003704	putative metal binding site [ion binding]; other site
1114965003705	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c_3; pfam13589
1114965003706	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
1114965003707	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1114965003708	cofactor binding site; other site
1114965003709	DNA binding site [nucleotide binding]
1114965003710	substrate interaction site [chemical binding]; other site
1114965003711	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1114965003712	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
1114965003713	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1114965003714	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1114965003715	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1114965003716	Coenzyme A binding pocket [chemical binding]; other site
1114965003717	excinuclease ABC subunit B; Provisional; Region: PRK05298
1114965003718	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1114965003719	ATP binding site [chemical binding]; other site
1114965003720	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1114965003721	nucleotide binding region [chemical binding]; other site
1114965003722	ATP-binding site [chemical binding]; other site
1114965003723	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1114965003724	UvrB/uvrC motif; Region: UVR; pfam02151
1114965003725	CAAX protease self-immunity; Region: Abi; pfam02517
1114965003726	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1114965003727	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1114965003728	substrate binding pocket [chemical binding]; other site
1114965003729	membrane-bound complex binding site; other site
1114965003730	hinge residues; other site
1114965003731	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1114965003732	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1114965003733	substrate binding pocket [chemical binding]; other site
1114965003734	membrane-bound complex binding site; other site
1114965003735	hinge residues; other site
1114965003736	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1114965003737	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1114965003738	dimer interface [polypeptide binding]; other site
1114965003739	conserved gate region; other site
1114965003740	putative PBP binding loops; other site
1114965003741	ABC-ATPase subunit interface; other site
1114965003742	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1114965003743	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1114965003744	Walker A/P-loop; other site
1114965003745	ATP binding site [chemical binding]; other site
1114965003746	Q-loop/lid; other site
1114965003747	ABC transporter signature motif; other site
1114965003748	Walker B; other site
1114965003749	D-loop; other site
1114965003750	H-loop/switch region; other site
1114965003751	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1114965003752	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1114965003753	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1114965003754	Walker A/P-loop; other site
1114965003755	ATP binding site [chemical binding]; other site
1114965003756	Q-loop/lid; other site
1114965003757	ABC transporter signature motif; other site
1114965003758	Walker B; other site
1114965003759	D-loop; other site
1114965003760	H-loop/switch region; other site
1114965003761	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1114965003762	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1114965003763	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1114965003764	Walker A/P-loop; other site
1114965003765	ATP binding site [chemical binding]; other site
1114965003766	Q-loop/lid; other site
1114965003767	ABC transporter signature motif; other site
1114965003768	Walker B; other site
1114965003769	D-loop; other site
1114965003770	H-loop/switch region; other site
1114965003771	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1114965003772	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1114965003773	putative substrate translocation pore; other site
1114965003774	Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
1114965003775	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
1114965003776	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
1114965003777	putative dimer interface [polypeptide binding]; other site
1114965003778	putative anticodon binding site; other site
1114965003779	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
1114965003780	homodimer interface [polypeptide binding]; other site
1114965003781	motif 1; other site
1114965003782	motif 2; other site
1114965003783	active site
1114965003784	motif 3; other site
1114965003785	aspartate aminotransferase; Provisional; Region: PRK05764
1114965003786	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1114965003787	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1114965003788	homodimer interface [polypeptide binding]; other site
1114965003789	catalytic residue [active]
1114965003790	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353
1114965003791	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1114965003792	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1114965003793	MarR family; Region: MarR; pfam01047
1114965003794	Transposase IS200 like; Region: Y1_Tnp; pfam01797
1114965003795	hypothetical protein; Validated; Region: PRK02101
1114965003796	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
1114965003797	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
1114965003798	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
1114965003799	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1114965003800	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1114965003801	DNA-binding site [nucleotide binding]; DNA binding site
1114965003802	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1114965003803	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1114965003804	homodimer interface [polypeptide binding]; other site
1114965003805	catalytic residue [active]
1114965003806	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1114965003807	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1114965003808	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1114965003809	Walker A/P-loop; other site
1114965003810	ATP binding site [chemical binding]; other site
1114965003811	Q-loop/lid; other site
1114965003812	ABC transporter signature motif; other site
1114965003813	Walker B; other site
1114965003814	D-loop; other site
1114965003815	H-loop/switch region; other site
1114965003816	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1114965003817	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
1114965003818	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1114965003819	Walker A/P-loop; other site
1114965003820	ATP binding site [chemical binding]; other site
1114965003821	Q-loop/lid; other site
1114965003822	ABC transporter signature motif; other site
1114965003823	Walker B; other site
1114965003824	D-loop; other site
1114965003825	H-loop/switch region; other site
1114965003826	Protein of unknown function (DUF419); Region: DUF419; cl15265
1114965003827	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
1114965003828	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1114965003829	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1114965003830	TM-ABC transporter signature motif; other site
1114965003831	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1114965003832	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1114965003833	TM-ABC transporter signature motif; other site
1114965003834	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
1114965003835	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1114965003836	Walker A/P-loop; other site
1114965003837	ATP binding site [chemical binding]; other site
1114965003838	Q-loop/lid; other site
1114965003839	ABC transporter signature motif; other site
1114965003840	Walker B; other site
1114965003841	D-loop; other site
1114965003842	H-loop/switch region; other site
1114965003843	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1114965003844	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
1114965003845	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
1114965003846	ligand binding site [chemical binding]; other site
1114965003847	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
1114965003848	active site
1114965003849	catalytic motif [active]
1114965003850	Zn binding site [ion binding]; other site
1114965003851	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1114965003852	intersubunit interface [polypeptide binding]; other site
1114965003853	active site
1114965003854	catalytic residue [active]
1114965003855	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
1114965003856	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1114965003857	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1114965003858	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
1114965003859	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1114965003860	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1114965003861	S-adenosylmethionine binding site [chemical binding]; other site
1114965003862	pantothenate kinase; Provisional; Region: PRK05439
1114965003863	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
1114965003864	ATP-binding site [chemical binding]; other site
1114965003865	CoA-binding site [chemical binding]; other site
1114965003866	Mg2+-binding site [ion binding]; other site
1114965003867	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
1114965003868	topology modulation protein; Provisional; Region: PRK07261
1114965003869	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983
1114965003870	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
1114965003871	Predicted membrane protein [Function unknown]; Region: COG4640
1114965003872	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1114965003873	active site residue [active]
1114965003874	This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335
1114965003875	putative deacylase active site [active]
1114965003876	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
1114965003877	putative uracil binding site [chemical binding]; other site
1114965003878	putative active site [active]
1114965003879	dipeptidase PepV; Reviewed; Region: PRK07318
1114965003880	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
1114965003881	active site
1114965003882	metal binding site [ion binding]; metal-binding site
1114965003883	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
1114965003884	dimer interface [polypeptide binding]; other site
1114965003885	FMN binding site [chemical binding]; other site
1114965003886	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
1114965003887	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1114965003888	active site
1114965003889	metal binding site [ion binding]; metal-binding site
1114965003890	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1114965003891	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1114965003892	GIY-YIG motif/motif A; other site
1114965003893	active site
1114965003894	catalytic site [active]
1114965003895	putative DNA binding site [nucleotide binding]; other site
1114965003896	metal binding site [ion binding]; metal-binding site
1114965003897	UvrB/uvrC motif; Region: UVR; pfam02151
1114965003898	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1114965003899	CAAX protease self-immunity; Region: Abi; pfam02517
1114965003900	Protein of unknown function (DUF1461); Region: DUF1461; cl01862
1114965003901	HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2
1114965003902	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1114965003903	active site
1114965003904	motif I; other site
1114965003905	motif II; other site
1114965003906	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1114965003907	Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738
1114965003908	Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643
1114965003909	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1114965003910	active site
1114965003911	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1114965003912	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
1114965003913	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1114965003914	FeS/SAM binding site; other site
1114965003915	HemN C-terminal domain; Region: HemN_C; pfam06969
1114965003916	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1114965003917	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1114965003918	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1114965003919	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1114965003920	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
1114965003921	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
1114965003922	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
1114965003923	putative catalytic cysteine [active]
1114965003924	gamma-glutamyl kinase; Provisional; Region: PRK05429
1114965003925	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
1114965003926	nucleotide binding site [chemical binding]; other site
1114965003927	homotetrameric interface [polypeptide binding]; other site
1114965003928	putative phosphate binding site [ion binding]; other site
1114965003929	putative allosteric binding site; other site
1114965003930	PUA domain; Region: PUA; pfam01472
1114965003931	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1114965003932	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1114965003933	RNA binding surface [nucleotide binding]; other site
1114965003934	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1114965003935	active site
1114965003936	lipoprotein signal peptidase; Provisional; Region: PRK14797
1114965003937	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1114965003938	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1114965003939	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1114965003940	dimerization interface [polypeptide binding]; other site
1114965003941	6-phospho-beta-galactosidase; Provisional; Region: PRK13511
1114965003942	beta-galactosidase; Region: BGL; TIGR03356
1114965003943	phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394
1114965003944	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
1114965003945	PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565
1114965003946	active site
1114965003947	P-loop; other site
1114965003948	phosphorylation site [posttranslational modification]
1114965003949	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
1114965003950	methionine cluster; other site
1114965003951	active site
1114965003952	phosphorylation site [posttranslational modification]
1114965003953	metal binding site [ion binding]; metal-binding site
1114965003954	CAT RNA binding domain; Region: CAT_RBD; smart01061
1114965003955	transcriptional antiterminator BglG; Provisional; Region: PRK09772
1114965003956	PRD domain; Region: PRD; pfam00874
1114965003957	PRD domain; Region: PRD; pfam00874
1114965003958	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399
1114965003959	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
1114965003960	tagatose-6-phosphate kinase; Region: lacC; TIGR01231
1114965003961	putative substrate binding site [chemical binding]; other site
1114965003962	putative ATP binding site [chemical binding]; other site
1114965003963	galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622
1114965003964	galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621
1114965003965	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
1114965003966	PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611
1114965003967	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
1114965003968	active site
1114965003969	P-loop; other site
1114965003970	phosphorylation site [posttranslational modification]
1114965003971	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1114965003972	active site
1114965003973	phosphorylation site [posttranslational modification]
1114965003974	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1114965003975	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1114965003976	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1114965003977	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
1114965003978	Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868
1114965003979	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
1114965003980	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
1114965003981	Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874
1114965003982	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1114965003983	active site
1114965003984	metal binding site [ion binding]; metal-binding site
1114965003985	PEP synthetase regulatory protein; Provisional; Region: PRK05339
1114965003986	HTH domain; Region: HTH_11; pfam08279
1114965003987	FOG: CBS domain [General function prediction only]; Region: COG0517
1114965003988	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1114965003989	pyruvate phosphate dikinase; Provisional; Region: PRK09279
1114965003990	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
1114965003991	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1114965003992	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1114965003993	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
1114965003994	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
1114965003995	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
1114965003996	Ligand Binding Site [chemical binding]; other site
1114965003997	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1114965003998	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1114965003999	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1114965004000	catalytic residue [active]
1114965004001	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
1114965004002	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1114965004003	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1114965004004	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1114965004005	dimer interface [polypeptide binding]; other site
1114965004006	conserved gate region; other site
1114965004007	ABC-ATPase subunit interface; other site
1114965004008	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1114965004009	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1114965004010	dimer interface [polypeptide binding]; other site
1114965004011	conserved gate region; other site
1114965004012	putative PBP binding loops; other site
1114965004013	ABC-ATPase subunit interface; other site
1114965004014	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1114965004015	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
1114965004016	Walker A/P-loop; other site
1114965004017	ATP binding site [chemical binding]; other site
1114965004018	Q-loop/lid; other site
1114965004019	ABC transporter signature motif; other site
1114965004020	Walker B; other site
1114965004021	D-loop; other site
1114965004022	H-loop/switch region; other site
1114965004023	TOBE domain; Region: TOBE_2; pfam08402
1114965004024	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
1114965004025	FAD binding domain; Region: FAD_binding_4; pfam01565
1114965004026	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1114965004027	homoserine kinase; Provisional; Region: PRK01212
1114965004028	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1114965004029	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1114965004030	homoserine dehydrogenase; Provisional; Region: PRK06349
1114965004031	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1114965004032	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1114965004033	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
1114965004034	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1114965004035	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
1114965004036	putative active site [active]
1114965004037	putative metal binding site [ion binding]; other site
1114965004038	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
1114965004039	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1114965004040	Zn2+ binding site [ion binding]; other site
1114965004041	Mg2+ binding site [ion binding]; other site
1114965004042	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1114965004043	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1114965004044	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
1114965004045	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307
1114965004046	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
1114965004047	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1114965004048	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1114965004049	Walker A/P-loop; other site
1114965004050	ATP binding site [chemical binding]; other site
1114965004051	Q-loop/lid; other site
1114965004052	ABC transporter signature motif; other site
1114965004053	Walker B; other site
1114965004054	D-loop; other site
1114965004055	H-loop/switch region; other site
1114965004056	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
1114965004057	metal binding site [ion binding]; metal-binding site
1114965004058	x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371
1114965004059	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482
1114965004060	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
1114965004061	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
1114965004062	active site
1114965004063	Na/Ca binding site [ion binding]; other site
1114965004064	catalytic site [active]
1114965004065	Domain of unknown function (DUF1939); Region: DUF1939; pfam09154
1114965004066	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1114965004067	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1114965004068	catalytic residues [active]
1114965004069	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1114965004070	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; cl08482
1114965004071	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
1114965004072	argininosuccinate lyase; Provisional; Region: PRK00855
1114965004073	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
1114965004074	active sites [active]
1114965004075	tetramer interface [polypeptide binding]; other site
1114965004076	argininosuccinate synthase; Provisional; Region: PRK13820
1114965004077	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
1114965004078	ANP binding site [chemical binding]; other site
1114965004079	Substrate Binding Site II [chemical binding]; other site
1114965004080	Substrate Binding Site I [chemical binding]; other site
1114965004081	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1114965004082	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
1114965004083	peptide binding site [polypeptide binding]; other site
1114965004084	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
1114965004085	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
1114965004086	putative oligomer interface [polypeptide binding]; other site
1114965004087	putative active site [active]
1114965004088	metal binding site [ion binding]; metal-binding site
1114965004089	LXG domain of WXG superfamily; Region: LXG; pfam04740
1114965004090	Protein of unknown function (DUF4237); Region: DUF4237; pfam14021
1114965004091	type VII secretion effector, SACOL2603 family; Region: T7SS_SACOL2603; TIGR04197
1114965004092	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1114965004093	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1114965004094	Walker A/P-loop; other site
1114965004095	ATP binding site [chemical binding]; other site
1114965004096	Q-loop/lid; other site
1114965004097	ABC transporter signature motif; other site
1114965004098	Walker B; other site
1114965004099	D-loop; other site
1114965004100	H-loop/switch region; other site
1114965004101	Protein of unknown function (DUF1307); Region: DUF1307; cl01981
1114965004102	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
1114965004103	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1114965004104	NAD binding site [chemical binding]; other site
1114965004105	homodimer interface [polypeptide binding]; other site
1114965004106	active site
1114965004107	substrate binding site [chemical binding]; other site
1114965004108	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270
1114965004109	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
1114965004110	Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744
1114965004111	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
1114965004112	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1114965004113	motif II; other site
1114965004114	galactokinase; Provisional; Region: PRK05322
1114965004115	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
1114965004116	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1114965004117	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1114965004118	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1114965004119	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
1114965004120	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
1114965004121	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
1114965004122	sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852
1114965004123	Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355
1114965004124	active site
1114965004125	homodimer interface [polypeptide binding]; other site
1114965004126	catalytic site [active]
1114965004127	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1114965004128	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1114965004129	dimer interface [polypeptide binding]; other site
1114965004130	conserved gate region; other site
1114965004131	putative PBP binding loops; other site
1114965004132	ABC-ATPase subunit interface; other site
1114965004133	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1114965004134	dimer interface [polypeptide binding]; other site
1114965004135	conserved gate region; other site
1114965004136	putative PBP binding loops; other site
1114965004137	ABC-ATPase subunit interface; other site
1114965004138	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1114965004139	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1114965004140	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
1114965004141	Melibiase; Region: Melibiase; pfam02065
1114965004142	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1114965004143	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1114965004144	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1114965004145	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1114965004146	DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339
1114965004147	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1114965004148	DNA binding site [nucleotide binding]
1114965004149	Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544
1114965004150	putative dimerization interface [polypeptide binding]; other site
1114965004151	putative ligand binding site [chemical binding]; other site
1114965004152	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
1114965004153	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1114965004154	DNA-binding site [nucleotide binding]; DNA binding site
1114965004155	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
1114965004156	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
1114965004157	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1114965004158	active site
1114965004159	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1114965004160	active site
1114965004161	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
1114965004162	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1114965004163	dimerization interface [polypeptide binding]; other site
1114965004164	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1114965004165	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1114965004166	dimer interface [polypeptide binding]; other site
1114965004167	phosphorylation site [posttranslational modification]
1114965004168	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1114965004169	ATP binding site [chemical binding]; other site
1114965004170	Mg2+ binding site [ion binding]; other site
1114965004171	G-X-G motif; other site
1114965004172	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1114965004173	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1114965004174	active site
1114965004175	phosphorylation site [posttranslational modification]
1114965004176	intermolecular recognition site; other site
1114965004177	dimerization interface [polypeptide binding]; other site
1114965004178	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1114965004179	DNA binding site [nucleotide binding]
1114965004180	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1114965004181	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1114965004182	FtsX-like permease family; Region: FtsX; pfam02687
1114965004183	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1114965004184	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1114965004185	Walker A/P-loop; other site
1114965004186	ATP binding site [chemical binding]; other site
1114965004187	Q-loop/lid; other site
1114965004188	ABC transporter signature motif; other site
1114965004189	Walker B; other site
1114965004190	D-loop; other site
1114965004191	H-loop/switch region; other site
1114965004192	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1114965004193	Protein of unknown function, DUF624; Region: DUF624; pfam04854
1114965004194	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1114965004195	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1114965004196	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1114965004197	dimer interface [polypeptide binding]; other site
1114965004198	conserved gate region; other site
1114965004199	ABC-ATPase subunit interface; other site
1114965004200	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1114965004201	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1114965004202	dimer interface [polypeptide binding]; other site
1114965004203	conserved gate region; other site
1114965004204	ABC-ATPase subunit interface; other site
1114965004205	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1114965004206	Histidine kinase; Region: His_kinase; pfam06580
1114965004207	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1114965004208	ATP binding site [chemical binding]; other site
1114965004209	Mg2+ binding site [ion binding]; other site
1114965004210	G-X-G motif; other site
1114965004211	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
1114965004212	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1114965004213	active site
1114965004214	phosphorylation site [posttranslational modification]
1114965004215	intermolecular recognition site; other site
1114965004216	dimerization interface [polypeptide binding]; other site
1114965004217	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1114965004218	Protein of unknown function (DUF3272); Region: DUF3272; pfam11676
1114965004219	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
1114965004220	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1114965004221	Walker A motif; other site
1114965004222	ATP binding site [chemical binding]; other site
1114965004223	Walker B motif; other site
1114965004224	arginine finger; other site
1114965004225	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
1114965004226	GAF domain; Region: GAF_2; pfam13185
1114965004227	Predicted membrane protein [Function unknown]; Region: COG3619
1114965004228	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
1114965004229	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
1114965004230	Sugar specificity; other site
1114965004231	Pyrimidine base specificity; other site
1114965004232	ATP-binding site [chemical binding]; other site
1114965004233	Predicted flavoprotein [General function prediction only]; Region: COG0431
1114965004234	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1114965004235	FMN-binding domain; Region: FMN_bind; cl01081
1114965004236	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
1114965004237	L-aspartate oxidase; Provisional; Region: PRK06175
1114965004238	Predicted flavoprotein [General function prediction only]; Region: COG0431
1114965004239	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1114965004240	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
1114965004241	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1114965004242	putative substrate translocation pore; other site
1114965004243	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1114965004244	Helix-turn-helix domain; Region: HTH_18; pfam12833
1114965004245	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1114965004246	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
1114965004247	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
1114965004248	NAD binding site [chemical binding]; other site
1114965004249	substrate binding site [chemical binding]; other site
1114965004250	homodimer interface [polypeptide binding]; other site
1114965004251	active site
1114965004252	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
1114965004253	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
1114965004254	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
1114965004255	substrate binding site; other site
1114965004256	tetramer interface; other site
1114965004257	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
1114965004258	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1114965004259	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1114965004260	Uncharacterized conserved protein [Function unknown]; Region: COG0327
1114965004261	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
1114965004262	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
1114965004263	Family of unknown function (DUF633); Region: DUF633; pfam04816
1114965004264	putative S-transferase; Provisional; Region: PRK11752
1114965004265	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
1114965004266	C-terminal domain interface [polypeptide binding]; other site
1114965004267	GSH binding site (G-site) [chemical binding]; other site
1114965004268	dimer interface [polypeptide binding]; other site
1114965004269	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
1114965004270	dimer interface [polypeptide binding]; other site
1114965004271	N-terminal domain interface [polypeptide binding]; other site
1114965004272	active site
1114965004273	adenosine deaminase; Provisional; Region: PRK09358
1114965004274	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
1114965004275	active site
1114965004276	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1114965004277	Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar1; cd08583
1114965004278	putative active site [active]
1114965004279	catalytic site [active]
1114965004280	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
1114965004281	DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446
1114965004282	Homoserine O-succinyltransferase; Region: HTS; pfam04204
1114965004283	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
1114965004284	proposed active site lysine [active]
1114965004285	conserved cys residue [active]
1114965004286	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1114965004287	active site
1114965004288	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
1114965004289	DHH family; Region: DHH; pfam01368
1114965004290	DHHA1 domain; Region: DHHA1; pfam02272
1114965004291	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199
1114965004292	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1114965004293	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1114965004294	Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568
1114965004295	Coenzyme A binding pocket [chemical binding]; other site
1114965004296	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1114965004297	S-adenosylmethionine binding site [chemical binding]; other site
1114965004298	ubiquinone biosynthesis methyltransferase; Region: PLN02232
1114965004299	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1114965004300	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1114965004301	NAD(P) binding site [chemical binding]; other site
1114965004302	active site
1114965004303	ribonuclease Z; Region: RNase_Z; TIGR02651
1114965004304	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
1114965004305	GTPases [General function prediction only]; Region: HflX; COG2262
1114965004306	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
1114965004307	HflX GTPase family; Region: HflX; cd01878
1114965004308	G1 box; other site
1114965004309	GTP/Mg2+ binding site [chemical binding]; other site
1114965004310	Switch I region; other site
1114965004311	G2 box; other site
1114965004312	G3 box; other site
1114965004313	Switch II region; other site
1114965004314	G4 box; other site
1114965004315	G5 box; other site
1114965004316	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
1114965004317	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
1114965004318	Protein of unknown function (DUF3042); Region: DUF3042; pfam11240
1114965004319	Domain of unknown function (DUF4298); Region: DUF4298; pfam14131
1114965004320	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
1114965004321	Part of AAA domain; Region: AAA_19; pfam13245
1114965004322	Family description; Region: UvrD_C_2; pfam13538
1114965004323	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1114965004324	ATP-dependent nuclease subunit B; Region: rexB_recomb; TIGR02774
1114965004325	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1114965004326	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
1114965004327	catalytic residues [active]
1114965004328	dimer interface [polypeptide binding]; other site
1114965004329	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1114965004330	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1114965004331	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1114965004332	Walker A/P-loop; other site
1114965004333	ATP binding site [chemical binding]; other site
1114965004334	Q-loop/lid; other site
1114965004335	ABC transporter signature motif; other site
1114965004336	Walker B; other site
1114965004337	D-loop; other site
1114965004338	H-loop/switch region; other site
1114965004339	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1114965004340	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1114965004341	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1114965004342	Walker A/P-loop; other site
1114965004343	ATP binding site [chemical binding]; other site
1114965004344	Q-loop/lid; other site
1114965004345	ABC transporter signature motif; other site
1114965004346	Walker B; other site
1114965004347	D-loop; other site
1114965004348	H-loop/switch region; other site
1114965004349	Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974
1114965004350	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1114965004351	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
1114965004352	putative active site [active]
1114965004353	catalytic site [active]
1114965004354	putative metal binding site [ion binding]; other site
1114965004355	FtsX-like permease family; Region: FtsX; pfam02687
1114965004356	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1114965004357	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1114965004358	Walker A/P-loop; other site
1114965004359	ATP binding site [chemical binding]; other site
1114965004360	Q-loop/lid; other site
1114965004361	ABC transporter signature motif; other site
1114965004362	Walker B; other site
1114965004363	D-loop; other site
1114965004364	H-loop/switch region; other site
1114965004365	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1114965004366	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1114965004367	WHG domain; Region: WHG; pfam13305
1114965004368	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1114965004369	active site
1114965004370	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1114965004371	catalytic tetrad [active]
1114965004372	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
1114965004373	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
1114965004374	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1114965004375	Walker A/P-loop; other site
1114965004376	ATP binding site [chemical binding]; other site
1114965004377	Q-loop/lid; other site
1114965004378	ABC transporter signature motif; other site
1114965004379	Walker B; other site
1114965004380	D-loop; other site
1114965004381	H-loop/switch region; other site
1114965004382	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
1114965004383	Protein of unknown function (DUF3169); Region: DUF3169; pfam11368
1114965004384	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1114965004385	non-specific DNA binding site [nucleotide binding]; other site
1114965004386	salt bridge; other site
1114965004387	sequence-specific DNA binding site [nucleotide binding]; other site
1114965004388	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1114965004389	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1114965004390	Coenzyme A binding pocket [chemical binding]; other site
1114965004391	This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899
1114965004392	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
1114965004393	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
1114965004394	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
1114965004395	G1 box; other site
1114965004396	GTP/Mg2+ binding site [chemical binding]; other site
1114965004397	Switch I region; other site
1114965004398	G2 box; other site
1114965004399	G3 box; other site
1114965004400	Switch II region; other site
1114965004401	G4 box; other site
1114965004402	G5 box; other site
1114965004403	Nucleoside recognition; Region: Gate; pfam07670
1114965004404	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
1114965004405	Nucleoside recognition; Region: Gate; pfam07670
1114965004406	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1114965004407	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1114965004408	putative tRNA-binding site [nucleotide binding]; other site
1114965004409	B3/4 domain; Region: B3_4; pfam03483
1114965004410	tRNA synthetase B5 domain; Region: B5; smart00874
1114965004411	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
1114965004412	dimer interface [polypeptide binding]; other site
1114965004413	motif 1; other site
1114965004414	motif 3; other site
1114965004415	motif 2; other site
1114965004416	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
1114965004417	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1114965004418	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1114965004419	Coenzyme A binding pocket [chemical binding]; other site
1114965004420	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1114965004421	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1114965004422	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1114965004423	dimer interface [polypeptide binding]; other site
1114965004424	motif 1; other site
1114965004425	active site
1114965004426	motif 2; other site
1114965004427	motif 3; other site
1114965004428	ParB-like nuclease domain; Region: ParB; smart00470
1114965004429	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
1114965004430	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1114965004431	zinc binding site [ion binding]; other site
1114965004432	putative ligand binding site [chemical binding]; other site
1114965004433	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
1114965004434	Domain of unknown function (DUF814); Region: DUF814; pfam05670
1114965004435	Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527
1114965004436	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1114965004437	binding surface
1114965004438	TPR motif; other site
1114965004439	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1114965004440	binding surface
1114965004441	TPR motif; other site
1114965004442	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1114965004443	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1114965004444	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
1114965004445	enolase; Provisional; Region: eno; PRK00077
1114965004446	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1114965004447	dimer interface [polypeptide binding]; other site
1114965004448	metal binding site [ion binding]; metal-binding site
1114965004449	substrate binding pocket [chemical binding]; other site
1114965004450	Protein of unknown function (DUF1694); Region: DUF1694; cl02318
1114965004451	Albumin I; Region: Albumin_I; pfam08027
1114965004452	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
1114965004453	phosphoserine phosphatase SerB; Region: serB; TIGR00338
1114965004454	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1114965004455	motif II; other site
1114965004456	septation ring formation regulator EzrA; Provisional; Region: PRK04778
1114965004457	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
1114965004458	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1114965004459	Mg2+ binding site [ion binding]; other site
1114965004460	G-X-G motif; other site
1114965004461	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1114965004462	anchoring element; other site
1114965004463	dimer interface [polypeptide binding]; other site
1114965004464	ATP binding site [chemical binding]; other site
1114965004465	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1114965004466	active site
1114965004467	putative metal-binding site [ion binding]; other site
1114965004468	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1114965004469	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1114965004470	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1114965004471	motif II; other site
1114965004472	DJ-1 family protein; Region: not_thiJ; TIGR01383
1114965004473	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
1114965004474	conserved cys residue [active]
1114965004475	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
1114965004476	Predicted membrane protein [Function unknown]; Region: COG2855
1114965004477	bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK07246
1114965004478	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1114965004479	active site
1114965004480	catalytic site [active]
1114965004481	substrate binding site [chemical binding]; other site
1114965004482	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
1114965004483	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
1114965004484	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1114965004485	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
1114965004486	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
1114965004487	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
1114965004488	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1114965004489	Walker A/P-loop; other site
1114965004490	ATP binding site [chemical binding]; other site
1114965004491	Q-loop/lid; other site
1114965004492	ABC transporter signature motif; other site
1114965004493	Walker B; other site
1114965004494	D-loop; other site
1114965004495	H-loop/switch region; other site
1114965004496	peptide chain release factor 2; Validated; Region: prfB; PRK00578
1114965004497	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1114965004498	RF-1 domain; Region: RF-1; pfam00472
1114965004499	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1114965004500	putative phosphoesterase; Region: acc_ester; TIGR03729
1114965004501	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1114965004502	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
1114965004503	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1114965004504	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1114965004505	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
1114965004506	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1114965004507	Domain of unknown function (DUF1934); Region: DUF1934; pfam09148
1114965004508	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
1114965004509	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1114965004510	Zn2+ binding site [ion binding]; other site
1114965004511	Mg2+ binding site [ion binding]; other site
1114965004512	sugar phosphate phosphatase; Provisional; Region: PRK10513
1114965004513	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1114965004514	active site
1114965004515	motif I; other site
1114965004516	motif II; other site
1114965004517	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1114965004518	FemAB family; Region: FemAB; pfam02388
1114965004519	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
1114965004520	FemAB family; Region: FemAB; pfam02388
1114965004521	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
1114965004522	triosephosphate isomerase; Provisional; Region: PRK14567
1114965004523	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1114965004524	substrate binding site [chemical binding]; other site
1114965004525	dimer interface [polypeptide binding]; other site
1114965004526	catalytic triad [active]
1114965004527	elongation factor Tu; Reviewed; Region: PRK00049
1114965004528	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1114965004529	G1 box; other site
1114965004530	GEF interaction site [polypeptide binding]; other site
1114965004531	GTP/Mg2+ binding site [chemical binding]; other site
1114965004532	Switch I region; other site
1114965004533	G2 box; other site
1114965004534	G3 box; other site
1114965004535	Switch II region; other site
1114965004536	G4 box; other site
1114965004537	G5 box; other site
1114965004538	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1114965004539	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1114965004540	Antibiotic Binding Site [chemical binding]; other site
1114965004541	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
1114965004542	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
1114965004543	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
1114965004544	Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757
1114965004545	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
1114965004546	active site
1114965004547	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
1114965004548	putative deacylase active site [active]
1114965004549	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1114965004550	catalytic core [active]
1114965004551	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
1114965004552	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
1114965004553	dimer interface [polypeptide binding]; other site
1114965004554	putative anticodon binding site; other site
1114965004555	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
1114965004556	motif 1; other site
1114965004557	active site
1114965004558	motif 2; other site
1114965004559	motif 3; other site
1114965004560	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1114965004561	FtsX-like permease family; Region: FtsX; pfam02687
1114965004562	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1114965004563	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1114965004564	Walker A/P-loop; other site
1114965004565	ATP binding site [chemical binding]; other site
1114965004566	Q-loop/lid; other site
1114965004567	ABC transporter signature motif; other site
1114965004568	Walker B; other site
1114965004569	D-loop; other site
1114965004570	H-loop/switch region; other site
1114965004571	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1114965004572	HlyD family secretion protein; Region: HlyD_3; pfam13437
1114965004573	glutathione reductase; Validated; Region: PRK06116
1114965004574	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1114965004575	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1114965004576	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1114965004577	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
1114965004578	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1114965004579	substrate binding site [chemical binding]; other site
1114965004580	THF binding site; other site
1114965004581	zinc-binding site [ion binding]; other site
1114965004582	Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901
1114965004583	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1114965004584	Peptidase family U32; Region: Peptidase_U32; pfam01136
1114965004585	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
1114965004586	Peptidase family U32; Region: Peptidase_U32; pfam01136
1114965004587	Protein of unknown function (DUF3270); Region: DUF3270; pfam11674
1114965004588	Transposase IS200 like; Region: Y1_Tnp; pfam01797
1114965004589	YtxH-like protein; Region: YtxH; pfam12732
1114965004590	Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768
1114965004591	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
1114965004592	HPr kinase/phosphorylase; Provisional; Region: PRK05428
1114965004593	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
1114965004594	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
1114965004595	Hpr binding site; other site
1114965004596	active site
1114965004597	homohexamer subunit interaction site [polypeptide binding]; other site
1114965004598	PspC domain; Region: PspC; pfam04024
1114965004599	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
1114965004600	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
1114965004601	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
1114965004602	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
1114965004603	RNA binding site [nucleotide binding]; other site
1114965004604	Predicted permeases [General function prediction only]; Region: COG0701
1114965004605	Predicted membrane protein [Function unknown]; Region: COG3689
1114965004606	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
1114965004607	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1114965004608	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1114965004609	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
1114965004610	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
1114965004611	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1114965004612	P loop; other site
1114965004613	GTP binding site [chemical binding]; other site
1114965004614	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1114965004615	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1114965004616	active site
1114965004617	motif I; other site
1114965004618	motif II; other site
1114965004619	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1114965004620	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1114965004621	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1114965004622	active site
1114965004623	motif I; other site
1114965004624	motif II; other site
1114965004625	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1114965004626	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
1114965004627	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1114965004628	Walker A/P-loop; other site
1114965004629	ATP binding site [chemical binding]; other site
1114965004630	Q-loop/lid; other site
1114965004631	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
1114965004632	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1114965004633	ABC transporter signature motif; other site
1114965004634	Walker B; other site
1114965004635	D-loop; other site
1114965004636	H-loop/switch region; other site
1114965004637	ribonuclease III; Reviewed; Region: rnc; PRK00102
1114965004638	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1114965004639	dimerization interface [polypeptide binding]; other site
1114965004640	active site
1114965004641	metal binding site [ion binding]; metal-binding site
1114965004642	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1114965004643	dsRNA binding site [nucleotide binding]; other site
1114965004644	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
1114965004645	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
1114965004646	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1114965004647	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
1114965004648	PAS domain; Region: PAS; smart00091
1114965004649	putative active site [active]
1114965004650	heme pocket [chemical binding]; other site
1114965004651	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1114965004652	dimer interface [polypeptide binding]; other site
1114965004653	phosphorylation site [posttranslational modification]
1114965004654	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1114965004655	ATP binding site [chemical binding]; other site
1114965004656	Mg2+ binding site [ion binding]; other site
1114965004657	G-X-G motif; other site
1114965004658	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1114965004659	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1114965004660	active site
1114965004661	phosphorylation site [posttranslational modification]
1114965004662	intermolecular recognition site; other site
1114965004663	dimerization interface [polypeptide binding]; other site
1114965004664	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1114965004665	DNA binding site [nucleotide binding]
1114965004666	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
1114965004667	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
1114965004668	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1114965004669	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1114965004670	active site
1114965004671	dimer interface [polypeptide binding]; other site
1114965004672	motif 1; other site
1114965004673	motif 2; other site
1114965004674	motif 3; other site
1114965004675	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1114965004676	anticodon binding site; other site
1114965004677	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1114965004678	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
1114965004679	putative ADP-binding pocket [chemical binding]; other site
1114965004680	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1114965004681	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1114965004682	catabolite control protein A; Region: ccpA; TIGR01481
1114965004683	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1114965004684	DNA binding site [nucleotide binding]
1114965004685	domain linker motif; other site
1114965004686	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
1114965004687	dimerization interface [polypeptide binding]; other site
1114965004688	effector binding site; other site
1114965004689	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1114965004690	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1114965004691	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1114965004692	active site
1114965004693	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1114965004694	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1114965004695	dimerization interface [polypeptide binding]; other site
1114965004696	putative Zn2+ binding site [ion binding]; other site
1114965004697	putative DNA binding site [nucleotide binding]; other site
1114965004698	Transposase; Region: HTH_Tnp_1; cl17663
1114965004699	HTH-like domain; Region: HTH_21; pfam13276
1114965004700	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
1114965004701	Integrase core domain; Region: rve; pfam00665
1114965004702	Integrase core domain; Region: rve_2; pfam13333
1114965004703	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
1114965004704	Predicted transcriptional regulator [Transcription]; Region: COG1959
1114965004705	Transcriptional regulator; Region: Rrf2; pfam02082
1114965004706	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1114965004707	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1114965004708	active site
1114965004709	metal binding site [ion binding]; metal-binding site
1114965004710	The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature; Region: BAR; cl12013
1114965004711	FtsX-like permease family; Region: FtsX; pfam02687
1114965004712	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1114965004713	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1114965004714	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1114965004715	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1114965004716	Walker A/P-loop; other site
1114965004717	ATP binding site [chemical binding]; other site
1114965004718	Q-loop/lid; other site
1114965004719	ABC transporter signature motif; other site
1114965004720	Walker B; other site
1114965004721	D-loop; other site
1114965004722	H-loop/switch region; other site
1114965004723	manganese transport protein MntH; Reviewed; Region: PRK00701
1114965004724	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
1114965004725	Transposase IS200 like; Region: Y1_Tnp; pfam01797
1114965004726	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1114965004727	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1114965004728	tellurite resistance protein TehB; Provisional; Region: PRK12335
1114965004729	Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615
1114965004730	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1114965004731	S-adenosylmethionine binding site [chemical binding]; other site
1114965004732	Peptidase family C69; Region: Peptidase_C69; cl17793
1114965004733	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
1114965004734	SmpB-tmRNA interface; other site
1114965004735	ribonuclease R; Region: RNase_R; TIGR02063
1114965004736	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
1114965004737	RNB domain; Region: RNB; pfam00773
1114965004738	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
1114965004739	RNA binding site [nucleotide binding]; other site
1114965004740	Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314
1114965004741	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1114965004742	putative substrate translocation pore; other site
1114965004743	dephospho-CoA kinase; Region: TIGR00152
1114965004744	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1114965004745	CoA-binding site [chemical binding]; other site
1114965004746	ATP-binding [chemical binding]; other site
1114965004747	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
1114965004748	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
1114965004749	DNA binding site [nucleotide binding]
1114965004750	catalytic residue [active]
1114965004751	H2TH interface [polypeptide binding]; other site
1114965004752	putative catalytic residues [active]
1114965004753	turnover-facilitating residue; other site
1114965004754	intercalation triad [nucleotide binding]; other site
1114965004755	8OG recognition residue [nucleotide binding]; other site
1114965004756	putative reading head residues; other site
1114965004757	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1114965004758	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1114965004759	GTPase Era; Reviewed; Region: era; PRK00089
1114965004760	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
1114965004761	G1 box; other site
1114965004762	GTP/Mg2+ binding site [chemical binding]; other site
1114965004763	Switch I region; other site
1114965004764	G2 box; other site
1114965004765	Switch II region; other site
1114965004766	G3 box; other site
1114965004767	G4 box; other site
1114965004768	G5 box; other site
1114965004769	KH domain; Region: KH_2; pfam07650
1114965004770	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
1114965004771	metal-binding heat shock protein; Provisional; Region: PRK00016
1114965004772	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1114965004773	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1114965004774	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
1114965004775	Walker A/P-loop; other site
1114965004776	ATP binding site [chemical binding]; other site
1114965004777	Q-loop/lid; other site
1114965004778	ABC transporter signature motif; other site
1114965004779	Walker B; other site
1114965004780	D-loop; other site
1114965004781	H-loop/switch region; other site
1114965004782	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1114965004783	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1114965004784	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1114965004785	Walker A/P-loop; other site
1114965004786	ATP binding site [chemical binding]; other site
1114965004787	Q-loop/lid; other site
1114965004788	ABC transporter signature motif; other site
1114965004789	Walker B; other site
1114965004790	D-loop; other site
1114965004791	H-loop/switch region; other site
1114965004792	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1114965004793	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1114965004794	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
1114965004795	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
1114965004796	hexamer interface [polypeptide binding]; other site
1114965004797	ligand binding site [chemical binding]; other site
1114965004798	putative active site [active]
1114965004799	NAD(P) binding site [chemical binding]; other site
1114965004800	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
1114965004801	PhoH-like protein; Region: PhoH; pfam02562
1114965004802	hypothetical protein; Provisional; Region: PRK13672
1114965004803	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
1114965004804	S1 domain; Region: S1_2; pfam13509
1114965004805	ribosome recycling factor; Reviewed; Region: frr; PRK00083
1114965004806	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1114965004807	hinge region; other site
1114965004808	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1114965004809	putative nucleotide binding site [chemical binding]; other site
1114965004810	uridine monophosphate binding site [chemical binding]; other site
1114965004811	homohexameric interface [polypeptide binding]; other site
1114965004812	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1114965004813	mRNA/rRNA interface [nucleotide binding]; other site
1114965004814	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
1114965004815	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
1114965004816	23S rRNA interface [nucleotide binding]; other site
1114965004817	L7/L12 interface [polypeptide binding]; other site
1114965004818	putative thiostrepton binding site; other site
1114965004819	L25 interface [polypeptide binding]; other site
1114965004820	Protein of unknown function (DUF3397); Region: DUF3397; pfam11877
1114965004821	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
1114965004822	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1114965004823	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1114965004824	motif II; other site
1114965004825	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1114965004826	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1114965004827	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1114965004828	active site
1114965004829	metal binding site [ion binding]; metal-binding site
1114965004830	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1114965004831	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1114965004832	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
1114965004833	Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652
1114965004834	active site
1114965004835	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
1114965004836	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1114965004837	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1114965004838	ABC transporter; Region: ABC_tran_2; pfam12848
1114965004839	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1114965004840	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
1114965004841	ArsC family; Region: ArsC; pfam03960
1114965004842	putative ArsC-like catalytic residues; other site
1114965004843	putative TRX-like catalytic residues [active]
1114965004844	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1114965004845	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1114965004846	DNA binding site [nucleotide binding]
1114965004847	active site
1114965004848	Predicted methyltransferases [General function prediction only]; Region: COG0313
1114965004849	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
1114965004850	putative SAM binding site [chemical binding]; other site
1114965004851	putative homodimer interface [polypeptide binding]; other site
1114965004852	DNA replication intiation control protein YabA; Reviewed; Region: PRK13169
1114965004853	DNA polymerase III subunit delta'; Validated; Region: PRK07276
1114965004854	DNA polymerase III subunit delta'; Validated; Region: PRK08485
1114965004855	thymidylate kinase; Validated; Region: tmk; PRK00698
1114965004856	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
1114965004857	TMP-binding site; other site
1114965004858	ATP-binding site [chemical binding]; other site
1114965004859	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1114965004860	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1114965004861	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1114965004862	FOG: CBS domain [General function prediction only]; Region: COG0517
1114965004863	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc2; cd04585
1114965004864	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1114965004865	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1114965004866	Walker A/P-loop; other site
1114965004867	ATP binding site [chemical binding]; other site
1114965004868	Q-loop/lid; other site
1114965004869	ABC transporter signature motif; other site
1114965004870	Walker B; other site
1114965004871	D-loop; other site
1114965004872	H-loop/switch region; other site
1114965004873	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1114965004874	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1114965004875	Walker A/P-loop; other site
1114965004876	ATP binding site [chemical binding]; other site
1114965004877	Q-loop/lid; other site
1114965004878	ABC transporter signature motif; other site
1114965004879	Walker B; other site
1114965004880	D-loop; other site
1114965004881	H-loop/switch region; other site
1114965004882	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1114965004883	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1114965004884	TM-ABC transporter signature motif; other site
1114965004885	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1114965004886	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1114965004887	TM-ABC transporter signature motif; other site
1114965004888	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1114965004889	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
1114965004890	putative ligand binding site [chemical binding]; other site
1114965004891	hypothetical protein; Provisional; Region: PRK02302
1114965004892	Clp protease; Region: CLP_protease; pfam00574
1114965004893	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1114965004894	oligomer interface [polypeptide binding]; other site
1114965004895	active site residues [active]
1114965004896	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1114965004897	active site
1114965004898	magnesium-transporting ATPase; Provisional; Region: PRK15122
1114965004899	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
1114965004900	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1114965004901	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
1114965004902	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1114965004903	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
1114965004904	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
1114965004905	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1114965004906	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1114965004907	homodimer interface [polypeptide binding]; other site
1114965004908	catalytic residue [active]
1114965004909	cystathionine gamma-synthase; Reviewed; Region: PRK07269
1114965004910	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1114965004911	homodimer interface [polypeptide binding]; other site
1114965004912	substrate-cofactor binding pocket; other site
1114965004913	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1114965004914	catalytic residue [active]
1114965004915	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1114965004916	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
1114965004917	UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022
1114965004918	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1114965004919	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1114965004920	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1114965004921	Domain of unknown function (DUF1803); Region: DUF1803; pfam08820
1114965004922	Domain of unknown function (DUF1803); Region: DUF1803; pfam08820
1114965004923	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
1114965004924	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
1114965004925	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
1114965004926	DHH family; Region: DHH; pfam01368
1114965004927	DHHA2 domain; Region: DHHA2; pfam02833
1114965004928	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
1114965004929	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1114965004930	FeS/SAM binding site; other site
1114965004931	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
1114965004932	generic binding surface I; other site
1114965004933	generic binding surface II; other site
1114965004934	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1114965004935	putative catalytic site [active]
1114965004936	putative metal binding site [ion binding]; other site
1114965004937	putative phosphate binding site [ion binding]; other site
1114965004938	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
1114965004939	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1114965004940	Ca binding site [ion binding]; other site
1114965004941	active site
1114965004942	catalytic site [active]
1114965004943	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
1114965004944	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1114965004945	active site turn [active]
1114965004946	phosphorylation site [posttranslational modification]
1114965004947	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1114965004948	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
1114965004949	HPr interaction site; other site
1114965004950	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1114965004951	active site
1114965004952	phosphorylation site [posttranslational modification]
1114965004953	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1114965004954	DNA-binding site [nucleotide binding]; DNA binding site
1114965004955	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
1114965004956	UTRA domain; Region: UTRA; pfam07702
1114965004957	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
1114965004958	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1114965004959	Walker A/P-loop; other site
1114965004960	ATP binding site [chemical binding]; other site
1114965004961	Q-loop/lid; other site
1114965004962	ABC transporter signature motif; other site
1114965004963	Walker B; other site
1114965004964	D-loop; other site
1114965004965	H-loop/switch region; other site
1114965004966	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1114965004967	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
1114965004968	TM-ABC transporter signature motif; other site
1114965004969	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
1114965004970	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1114965004971	zinc binding site [ion binding]; other site
1114965004972	putative ligand binding site [chemical binding]; other site
1114965004973	Domain of unknown function DUF21; Region: DUF21; pfam01595
1114965004974	gliding motility-associated protein GldE; Region: GldE; TIGR03520
1114965004975	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1114965004976	Transporter associated domain; Region: CorC_HlyC; smart01091
1114965004977	M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280
1114965004978	Mga helix-turn-helix domain; Region: Mga; pfam05043
1114965004979	M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270
1114965004980	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1114965004981	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1114965004982	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1114965004983	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1114965004984	Walker A/P-loop; other site
1114965004985	ATP binding site [chemical binding]; other site
1114965004986	Q-loop/lid; other site
1114965004987	ABC transporter signature motif; other site
1114965004988	Walker B; other site
1114965004989	D-loop; other site
1114965004990	H-loop/switch region; other site
1114965004991	Collagen binding domain; Region: Collagen_bind; pfam05737
1114965004992	Cna protein B-type domain; Region: Cna_B; pfam05738
1114965004993	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
1114965004994	domain interaction interfaces [polypeptide binding]; other site
1114965004995	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
1114965004996	domain interaction interfaces [polypeptide binding]; other site
1114965004997	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
1114965004998	domain interaction interfaces [polypeptide binding]; other site
1114965004999	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
1114965005000	domain interaction interfaces [polypeptide binding]; other site
1114965005001	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
1114965005002	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
1114965005003	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1114965005004	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1114965005005	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1114965005006	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
1114965005007	T surface-antigen of pili; Region: FctA; pfam12892
1114965005008	T surface-antigen of pili; Region: FctA; pfam12892
1114965005009	T surface-antigen of pili; Region: FctA; pfam12892
1114965005010	T surface-antigen of pili; Region: FctA; pfam12892
1114965005011	T surface-antigen of pili; Region: FctA; pfam12892
1114965005012	T surface-antigen of pili; Region: FctA; pfam12892
1114965005013	T surface-antigen of pili; Region: FctA; pfam12892
1114965005014	T surface-antigen of pili; Region: FctA; pfam12892
1114965005015	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1114965005016	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
1114965005017	Putative rRNA methylase; Region: rRNA_methylase; pfam06962
1114965005018	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
1114965005019	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
1114965005020	active site
1114965005021	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1114965005022	Predicted membrane protein [Function unknown]; Region: COG3601
1114965005023	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
1114965005024	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
1114965005025	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
1114965005026	TrkA-N domain; Region: TrkA_N; pfam02254
1114965005027	TrkA-C domain; Region: TrkA_C; pfam02080
1114965005028	TrkA-N domain; Region: TrkA_N; pfam02254
1114965005029	TrkA-C domain; Region: TrkA_C; pfam02080
1114965005030	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
1114965005031	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1114965005032	hypothetical protein; Validated; Region: PRK00041
1114965005033	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1114965005034	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1114965005035	RNA binding surface [nucleotide binding]; other site
1114965005036	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
1114965005037	active site
1114965005038	segregation and condensation protein B; Reviewed; Region: scpB; PRK00135
1114965005039	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
1114965005040	site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436
1114965005041	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1114965005042	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1114965005043	DNA binding site [nucleotide binding]
1114965005044	Int/Topo IB signature motif; other site
1114965005045	active site
1114965005046	catalytic residues [active]
1114965005047	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643
1114965005048	FOG: CBS domain [General function prediction only]; Region: COG0517
1114965005049	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
1114965005050	active site
1114965005051	metal binding site [ion binding]; metal-binding site
1114965005052	homotetramer interface [polypeptide binding]; other site
1114965005053	putative deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein; Reviewed; Region: PRK02491
1114965005054	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1114965005055	active site
1114965005056	dimerization interface [polypeptide binding]; other site
1114965005057	glutamate racemase; Provisional; Region: PRK00865
1114965005058	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763
1114965005059	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
1114965005060	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1114965005061	active site
1114965005062	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1114965005063	substrate binding site [chemical binding]; other site
1114965005064	catalytic residues [active]
1114965005065	dimer interface [polypeptide binding]; other site
1114965005066	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
1114965005067	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
1114965005068	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
1114965005069	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
1114965005070	Zn2+ binding site [ion binding]; other site
1114965005071	Mg2+ binding site [ion binding]; other site
1114965005072	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
1114965005073	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
1114965005074	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1114965005075	acylphosphatase; Provisional; Region: PRK14434
1114965005076	OxaA-like protein precursor; Provisional; Region: PRK02463
1114965005077	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
1114965005078	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1114965005079	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1114965005080	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1114965005081	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1114965005082	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1114965005083	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1114965005084	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
1114965005085	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
1114965005086	dimerization interface [polypeptide binding]; other site
1114965005087	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1114965005088	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1114965005089	Coenzyme A binding pocket [chemical binding]; other site
1114965005090	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1114965005091	Coenzyme A binding pocket [chemical binding]; other site
1114965005092	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
1114965005093	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1114965005094	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1114965005095	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1114965005096	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
1114965005097	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
1114965005098	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1114965005099	ATP binding site [chemical binding]; other site
1114965005100	putative Mg++ binding site [ion binding]; other site
1114965005101	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
1114965005102	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1114965005103	nucleotide binding region [chemical binding]; other site
1114965005104	ATP-binding site [chemical binding]; other site
1114965005105	GTP-binding protein Der; Reviewed; Region: PRK00093
1114965005106	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1114965005107	G1 box; other site
1114965005108	GTP/Mg2+ binding site [chemical binding]; other site
1114965005109	Switch I region; other site
1114965005110	G2 box; other site
1114965005111	Switch II region; other site
1114965005112	G3 box; other site
1114965005113	G4 box; other site
1114965005114	G5 box; other site
1114965005115	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1114965005116	G1 box; other site
1114965005117	GTP/Mg2+ binding site [chemical binding]; other site
1114965005118	Switch I region; other site
1114965005119	G2 box; other site
1114965005120	G3 box; other site
1114965005121	Switch II region; other site
1114965005122	G4 box; other site
1114965005123	G5 box; other site
1114965005124	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
1114965005125	dimer interface [polypeptide binding]; other site
1114965005126	FMN binding site [chemical binding]; other site
1114965005127	NADPH bind site [chemical binding]; other site
1114965005128	primosomal protein DnaI; Reviewed; Region: PRK08939
1114965005129	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
1114965005130	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1114965005131	Walker A motif; other site
1114965005132	ATP binding site [chemical binding]; other site
1114965005133	Walker B motif; other site
1114965005134	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
1114965005135	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
1114965005136	ATP cone domain; Region: ATP-cone; pfam03477
1114965005137	Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079
1114965005138	putative catalytic site [active]
1114965005139	putative metal binding site [ion binding]; other site
1114965005140	putative phosphate binding site [ion binding]; other site
1114965005141	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1114965005142	PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003
1114965005143	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1114965005144	active site turn [active]
1114965005145	phosphorylation site [posttranslational modification]
1114965005146	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
1114965005147	HPr interaction site; other site
1114965005148	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1114965005149	active site
1114965005150	phosphorylation site [posttranslational modification]
1114965005151	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1114965005152	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1114965005153	active site
1114965005154	phosphorylation site [posttranslational modification]
1114965005155	intermolecular recognition site; other site
1114965005156	dimerization interface [polypeptide binding]; other site
1114965005157	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1114965005158	DNA binding site [nucleotide binding]
1114965005159	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1114965005160	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
1114965005161	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
1114965005162	Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  These two proteins are lipid raft-associated.  Individual proteins of...; Region: Band_7_flotillin; cd03399
1114965005163	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
1114965005164	Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; cl02047
1114965005165	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1114965005166	non-specific DNA binding site [nucleotide binding]; other site
1114965005167	salt bridge; other site
1114965005168	sequence-specific DNA binding site [nucleotide binding]; other site
1114965005169	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
1114965005170	H+ Antiporter protein; Region: 2A0121; TIGR00900
1114965005171	heat shock protein HtpX; Provisional; Region: PRK04897
1114965005172	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
1114965005173	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
1114965005174	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1114965005175	S-adenosylmethionine binding site [chemical binding]; other site
1114965005176	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1114965005177	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
1114965005178	substrate binding site [chemical binding]; other site
1114965005179	ATP binding site [chemical binding]; other site
1114965005180	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
1114965005181	malonic semialdehyde reductase; Provisional; Region: PRK10538
1114965005182	putative NAD(P) binding site [chemical binding]; other site
1114965005183	homodimer interface [polypeptide binding]; other site
1114965005184	homotetramer interface [polypeptide binding]; other site
1114965005185	active site
1114965005186	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1114965005187	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1114965005188	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1114965005189	Walker A/P-loop; other site
1114965005190	ATP binding site [chemical binding]; other site
1114965005191	Q-loop/lid; other site
1114965005192	ABC transporter signature motif; other site
1114965005193	Walker B; other site
1114965005194	D-loop; other site
1114965005195	H-loop/switch region; other site
1114965005196	ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558
1114965005197	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1114965005198	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1114965005199	Walker A/P-loop; other site
1114965005200	ATP binding site [chemical binding]; other site
1114965005201	Q-loop/lid; other site
1114965005202	ABC transporter signature motif; other site
1114965005203	Walker B; other site
1114965005204	D-loop; other site
1114965005205	H-loop/switch region; other site
1114965005206	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
1114965005207	Domain of unknown function (DUF4299); Region: DUF4299; pfam14132
1114965005208	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
1114965005209	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
1114965005210	active site residue [active]
1114965005211	Protein of unknown function (DUF3650); Region: DUF3650; pfam12368
1114965005212	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1114965005213	non-specific DNA binding site [nucleotide binding]; other site
1114965005214	salt bridge; other site
1114965005215	sequence-specific DNA binding site [nucleotide binding]; other site
1114965005216	hypothetical protein; Provisional; Region: PRK13661
1114965005217	Uncharacterized conserved protein [Function unknown]; Region: COG1912
1114965005218	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; cl09823
1114965005219	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1114965005220	dimer interface [polypeptide binding]; other site
1114965005221	conserved gate region; other site
1114965005222	ABC-ATPase subunit interface; other site
1114965005223	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
1114965005224	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
1114965005225	Walker A/P-loop; other site
1114965005226	ATP binding site [chemical binding]; other site
1114965005227	Q-loop/lid; other site
1114965005228	ABC transporter signature motif; other site
1114965005229	Walker B; other site
1114965005230	D-loop; other site
1114965005231	H-loop/switch region; other site
1114965005232	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
1114965005233	hypothetical protein; Provisional; Region: PRK06446
1114965005234	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681
1114965005235	metal binding site [ion binding]; metal-binding site
1114965005236	dimer interface [polypeptide binding]; other site
1114965005237	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
1114965005238	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
1114965005239	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1114965005240	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1114965005241	substrate binding pocket [chemical binding]; other site
1114965005242	membrane-bound complex binding site; other site
1114965005243	hinge residues; other site
1114965005244	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
1114965005245	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1114965005246	metal binding site [ion binding]; metal-binding site
1114965005247	Domain of unknown function (DUF4352); Region: DUF4352; pfam11611
1114965005248	EamA-like transporter family; Region: EamA; pfam00892
1114965005249	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1114965005250	(2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233
1114965005251	putative NAD(P) binding site [chemical binding]; other site
1114965005252	catalytic Zn binding site [ion binding]; other site
1114965005253	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
1114965005254	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
1114965005255	GatB domain; Region: GatB_Yqey; pfam02637
1114965005256	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1114965005257	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
1114965005258	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
1114965005259	Isochorismatase family; Region: Isochorismatase; pfam00857
1114965005260	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
1114965005261	catalytic triad [active]
1114965005262	conserved cis-peptide bond; other site
1114965005263	transcriptional repressor CodY; Validated; Region: PRK04158
1114965005264	CodY GAF-like domain; Region: CodY; pfam06018
1114965005265	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1114965005266	dimerization interface [polypeptide binding]; other site
1114965005267	putative Zn2+ binding site [ion binding]; other site
1114965005268	putative DNA binding site [nucleotide binding]; other site
1114965005269	aminotransferase AlaT; Validated; Region: PRK09265
1114965005270	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1114965005271	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1114965005272	homodimer interface [polypeptide binding]; other site
1114965005273	catalytic residue [active]
1114965005274	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1114965005275	Ligand Binding Site [chemical binding]; other site
1114965005276	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1114965005277	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1114965005278	active site
1114965005279	motif I; other site
1114965005280	motif II; other site
1114965005281	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1114965005282	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4696
1114965005283	metal binding site [ion binding]; metal-binding site
1114965005284	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
1114965005285	active site
1114965005286	homotetramer interface [polypeptide binding]; other site
1114965005287	homodimer interface [polypeptide binding]; other site
1114965005288	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
1114965005289	Y-family of DNA polymerases; Region: PolY; cl12025
1114965005290	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1114965005291	ssDNA binding site; other site
1114965005292	generic binding surface II; other site
1114965005293	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1114965005294	ATP binding site [chemical binding]; other site
1114965005295	putative Mg++ binding site [ion binding]; other site
1114965005296	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1114965005297	nucleotide binding region [chemical binding]; other site
1114965005298	ATP-binding site [chemical binding]; other site
1114965005299	alanine racemase; Reviewed; Region: alr; PRK00053
1114965005300	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1114965005301	active site
1114965005302	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1114965005303	dimer interface [polypeptide binding]; other site
1114965005304	substrate binding site [chemical binding]; other site
1114965005305	catalytic residues [active]
1114965005306	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
1114965005307	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; cl17260
1114965005308	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1114965005309	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
1114965005310	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
1114965005311	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1114965005312	nucleotide binding region [chemical binding]; other site
1114965005313	ATP-binding site [chemical binding]; other site
1114965005314	SEC-C motif; Region: SEC-C; pfam02810
1114965005315	Amino acid permease; Region: AA_permease_2; pfam13520
1114965005316	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
1114965005317	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1114965005318	DNA binding residues [nucleotide binding]
1114965005319	dimer interface [polypeptide binding]; other site
1114965005320	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
1114965005321	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
1114965005322	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
1114965005323	epoxyqueuosine reductase; Region: TIGR00276
1114965005324	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
1114965005325	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1114965005326	Coenzyme A binding pocket [chemical binding]; other site
1114965005327	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
1114965005328	active site
1114965005329	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1114965005330	active site
1114965005331	catalytic residues [active]
1114965005332	metal binding site [ion binding]; metal-binding site
1114965005333	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1114965005334	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1114965005335	nucleotide binding site [chemical binding]; other site
1114965005336	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
1114965005337	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
1114965005338	active site turn [active]
1114965005339	phosphorylation site [posttranslational modification]
1114965005340	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
1114965005341	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
1114965005342	HPr interaction site; other site
1114965005343	glycerol kinase (GK) interaction site [polypeptide binding]; other site
1114965005344	active site
1114965005345	phosphorylation site [posttranslational modification]
1114965005346	sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322
1114965005347	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
1114965005348	substrate binding [chemical binding]; other site
1114965005349	active site
1114965005350	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
1114965005351	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1114965005352	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1114965005353	DNA binding site [nucleotide binding]
1114965005354	domain linker motif; other site
1114965005355	Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291
1114965005356	dimerization interface [polypeptide binding]; other site
1114965005357	ligand binding site [chemical binding]; other site
1114965005358	sodium binding site [ion binding]; other site
1114965005359	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
1114965005360	putative RNA binding site [nucleotide binding]; other site
1114965005361	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
1114965005362	elongation factor P; Validated; Region: PRK00529
1114965005363	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1114965005364	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1114965005365	RNA binding site [nucleotide binding]; other site
1114965005366	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1114965005367	RNA binding site [nucleotide binding]; other site
1114965005368	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1114965005369	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1114965005370	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
1114965005371	active site
1114965005372	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
1114965005373	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1114965005374	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1114965005375	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1114965005376	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
1114965005377	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
1114965005378	Cl binding site [ion binding]; other site
1114965005379	oligomer interface [polypeptide binding]; other site
1114965005380	Protein of unknown function (DUF1129); Region: DUF1129; pfam06570
1114965005381	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
1114965005382	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1114965005383	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
1114965005384	Transposase zinc-ribbon domain; Region: Zn_Tnp_IS1595; pfam12760
1114965005385	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762
1114965005386	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1114965005387	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1114965005388	Coenzyme A binding pocket [chemical binding]; other site
1114965005389	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1114965005390	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
1114965005391	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1114965005392	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1114965005393	dimer interface [polypeptide binding]; other site
1114965005394	ssDNA binding site [nucleotide binding]; other site
1114965005395	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1114965005396	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
1114965005397	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
1114965005398	Ligand binding site; other site
1114965005399	Putative Catalytic site; other site
1114965005400	DXD motif; other site
1114965005401	Predicted membrane protein [Function unknown]; Region: COG2246
1114965005402	GtrA-like protein; Region: GtrA; pfam04138
1114965005403	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
1114965005404	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
1114965005405	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
1114965005406	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
1114965005407	putative active site [active]
1114965005408	catalytic triad [active]
1114965005409	PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238
1114965005410	PA/protease or protease-like domain interface [polypeptide binding]; other site
1114965005411	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
1114965005412	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
1114965005413	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
1114965005414	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
1114965005415	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
1114965005416	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
1114965005417	putative active site [active]
1114965005418	catalytic triad [active]
1114965005419	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
1114965005420	putative active site [active]
1114965005421	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
1114965005422	C-terminal domain of CHU protein family; Region: CHU_C; cl17875
1114965005423	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1114965005424	Bacillus subtilis YhcR endonuclease and related proteins, N-terminal metallophosphatase domain; Region: MPP_YhcR_N; cd07412
1114965005425	putative active site [active]
1114965005426	putative metal binding site [ion binding]; other site
1114965005427	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1114965005428	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
1114965005429	putative phosphoketolase; Provisional; Region: PRK05261
1114965005430	XFP N-terminal domain; Region: XFP_N; pfam09364
1114965005431	XFP C-terminal domain; Region: XFP_C; pfam09363
1114965005432	imidazolonepropionase; Validated; Region: PRK09356
1114965005433	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
1114965005434	active site
1114965005435	urocanate hydratase; Provisional; Region: PRK05414
1114965005436	Glutamate formiminotransferase [Amino acid transport and metabolism]; Region: COG3643
1114965005437	Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837
1114965005438	Formiminotransferase domain; Region: FTCD; pfam02971
1114965005439	Formiminotransferase-cyclodeaminase; Region: FTCD_C; cl01350
1114965005440	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
1114965005441	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
1114965005442	Potassium binding sites [ion binding]; other site
1114965005443	Cesium cation binding sites [ion binding]; other site
1114965005444	HutD; Region: HutD; pfam05962
1114965005445	amino acid transporter; Region: 2A0306; TIGR00909
1114965005446	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
1114965005447	active sites [active]
1114965005448	tetramer interface [polypeptide binding]; other site
1114965005449	formimidoylglutamase; Provisional; Region: PRK13775
1114965005450	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
1114965005451	putative active site [active]
1114965005452	putative metal binding site [ion binding]; other site
1114965005453	Bacterial transcriptional activator domain; Region: BTAD; pfam03704
1114965005454	AAA domain; Region: AAA_22; pfam13401
1114965005455	AAA ATPase domain; Region: AAA_16; pfam13191
1114965005456	Tetratricopeptide repeat; Region: TPR_12; pfam13424
1114965005457	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
1114965005458	FAD binding site [chemical binding]; other site
1114965005459	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
1114965005460	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
1114965005461	THF binding site; other site
1114965005462	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1114965005463	substrate binding site [chemical binding]; other site
1114965005464	THF binding site; other site
1114965005465	zinc-binding site [ion binding]; other site
1114965005466	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
1114965005467	active site
1114965005468	catalytic site [active]
1114965005469	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
1114965005470	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
1114965005471	This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595
1114965005472	putative active site [active]
1114965005473	putative catalytic site [active]
1114965005474	CAAX protease self-immunity; Region: Abi; pfam02517
1114965005475	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
1114965005476	TrkA-N domain; Region: TrkA_N; pfam02254
1114965005477	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1114965005478	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
1114965005479	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
1114965005480	potential frameshift: common BLAST hit: gi|337282654|ref|YP_004622125.1| maltose O-acetyltransferase
1114965005481	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1114965005482	putative trimer interface [polypeptide binding]; other site
1114965005483	putative CoA binding site [chemical binding]; other site
1114965005484	Maltose acetyltransferase; Region: Mac; pfam12464
1114965005485	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1114965005486	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
1114965005487	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1114965005488	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1114965005489	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
1114965005490	active site
1114965005491	motif I; other site
1114965005492	motif II; other site
1114965005493	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1114965005494	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
1114965005495	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
1114965005496	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1114965005497	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1114965005498	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1114965005499	dimerization interface [polypeptide binding]; other site
1114965005500	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1114965005501	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287
1114965005502	catalytic Zn binding site [ion binding]; other site
1114965005503	NAD(P) binding site [chemical binding]; other site
1114965005504	structural Zn binding site [ion binding]; other site
1114965005505	Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276
1114965005506	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
1114965005507	active site
1114965005508	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
1114965005509	active site
1114965005510	N-terminal domain interface [polypeptide binding]; other site
1114965005511	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
1114965005512	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1114965005513	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1114965005514	Membrane transport protein; Region: Mem_trans; pfam03547
1114965005515	nicotinamide mononucleotide transporter PnuC; Region: NMN_trans_PnuC; TIGR01528
1114965005516	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1114965005517	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1114965005518	Walker A/P-loop; other site
1114965005519	ATP binding site [chemical binding]; other site
1114965005520	Q-loop/lid; other site
1114965005521	ABC transporter signature motif; other site
1114965005522	Walker B; other site
1114965005523	D-loop; other site
1114965005524	H-loop/switch region; other site
1114965005525	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1114965005526	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1114965005527	Walker A/P-loop; other site
1114965005528	ATP binding site [chemical binding]; other site
1114965005529	Q-loop/lid; other site
1114965005530	ABC transporter signature motif; other site
1114965005531	Walker B; other site
1114965005532	D-loop; other site
1114965005533	H-loop/switch region; other site
1114965005534	Cobalt transport protein; Region: CbiQ; cl00463
1114965005535	Acyltransferase family; Region: Acyl_transf_3; pfam01757
1114965005536	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
1114965005537	aminodeoxychorismate synthase; Provisional; Region: PRK07508
1114965005538	chorismate binding enzyme; Region: Chorismate_bind; cl10555
1114965005539	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
1114965005540	substrate-cofactor binding pocket; other site
1114965005541	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1114965005542	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1114965005543	catalytic residue [active]
1114965005544	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1114965005545	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1114965005546	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1114965005547	Walker A/P-loop; other site
1114965005548	ATP binding site [chemical binding]; other site
1114965005549	Q-loop/lid; other site
1114965005550	ABC transporter signature motif; other site
1114965005551	Walker B; other site
1114965005552	D-loop; other site
1114965005553	H-loop/switch region; other site
1114965005554	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
1114965005555	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1114965005556	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1114965005557	dimer interface [polypeptide binding]; other site
1114965005558	phosphorylation site [posttranslational modification]
1114965005559	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1114965005560	ATP binding site [chemical binding]; other site
1114965005561	Mg2+ binding site [ion binding]; other site
1114965005562	G-X-G motif; other site
1114965005563	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1114965005564	cheY-homologous receiver domain; Region: REC; smart00448
1114965005565	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1114965005566	active site
1114965005567	phosphorylation site [posttranslational modification]
1114965005568	intermolecular recognition site; other site
1114965005569	dimerization interface [polypeptide binding]; other site
1114965005570	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1114965005571	DNA binding site [nucleotide binding]
1114965005572	6-phospho-beta-glucosidase; Reviewed; Region: arb; PRK09593
1114965005573	beta-galactosidase; Region: BGL; TIGR03356
1114965005574	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
1114965005575	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1114965005576	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
1114965005577	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
1114965005578	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
1114965005579	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1114965005580	MFS/sugar transport protein; Region: MFS_2; pfam13347
1114965005581	putative substrate translocation pore; other site
1114965005582	Cupin domain; Region: Cupin_2; pfam07883
1114965005583	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1114965005584	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1114965005585	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1114965005586	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
1114965005587	Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531
1114965005588	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
1114965005589	beta-phosphoglucomutase; Region: bPGM; TIGR01990
1114965005590	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1114965005591	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1114965005592	motif II; other site
1114965005593	Glycosyl hydrolase family 43, beta-D-xylosidase; Region: GH43_XYL_1; cd09000
1114965005594	inhibitor binding site; inhibition site
1114965005595	active site
1114965005596	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
1114965005597	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
1114965005598	dimer interface [polypeptide binding]; other site
1114965005599	active site
1114965005600	metal binding site [ion binding]; metal-binding site
1114965005601	rhamnulose-1-phosphate aldolase; Provisional; Region: PRK03634
1114965005602	intersubunit interface [polypeptide binding]; other site
1114965005603	active site
1114965005604	Zn2+ binding site [ion binding]; other site
1114965005605	L-rhamnose isomerase; Provisional; Region: PRK01076
1114965005606	Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900
1114965005607	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
1114965005608	N- and C-terminal domain interface [polypeptide binding]; other site
1114965005609	rhamnulokinase; Region: rhamnulo_kin; TIGR02627
1114965005610	active site
1114965005611	putative catalytic site [active]
1114965005612	metal binding site [ion binding]; metal-binding site
1114965005613	ATP binding site [chemical binding]; other site
1114965005614	carbohydrate binding site [chemical binding]; other site
1114965005615	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1114965005616	Helix-turn-helix domain; Region: HTH_18; pfam12833
1114965005617	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1114965005618	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1114965005619	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1114965005620	active site
1114965005621	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
1114965005622	pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720
1114965005623	PYR/PP interface [polypeptide binding]; other site
1114965005624	dimer interface [polypeptide binding]; other site
1114965005625	tetramer interface [polypeptide binding]; other site
1114965005626	TPP binding site [chemical binding]; other site
1114965005627	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1114965005628	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
1114965005629	TPP-binding site [chemical binding]; other site
1114965005630	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
1114965005631	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
1114965005632	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1114965005633	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1114965005634	motif II; other site
1114965005635	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
1114965005636	Predicted transcriptional regulator [Transcription]; Region: COG3682
1114965005637	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
1114965005638	NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841
1114965005639	active site
1114965005640	catalytic triad [active]
1114965005641	oxyanion hole [active]
1114965005642	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
1114965005643	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1114965005644	active site
1114965005645	motif I; other site
1114965005646	motif II; other site
1114965005647	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1114965005648	HD domain; Region: HD_3; pfam13023
1114965005649	Protein of unknown function (DUF554); Region: DUF554; pfam04474
1114965005650	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1114965005651	Walker A/P-loop; other site
1114965005652	ATP binding site [chemical binding]; other site
1114965005653	Q-loop/lid; other site
1114965005654	ABC transporter signature motif; other site
1114965005655	Walker B; other site
1114965005656	D-loop; other site
1114965005657	H-loop/switch region; other site
1114965005658	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
1114965005659	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
1114965005660	putative active site [active]
1114965005661	putative metal binding site [ion binding]; other site
1114965005662	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
1114965005663	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
1114965005664	SelR domain; Region: SelR; pfam01641
1114965005665	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
1114965005666	Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741
1114965005667	active site
1114965005668	FMN binding site [chemical binding]; other site
1114965005669	substrate binding site [chemical binding]; other site
1114965005670	catalytic residues [active]
1114965005671	homodimer interface [polypeptide binding]; other site
1114965005672	glutamate dehydrogenase; Provisional; Region: PRK09414
1114965005673	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1114965005674	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
1114965005675	NAD(P) binding site [chemical binding]; other site
1114965005676	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1114965005677	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1114965005678	serine/threonine transporter SstT; Provisional; Region: PRK13628
1114965005679	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
1114965005680	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1114965005681	amino acid carrier protein; Region: agcS; TIGR00835
1114965005682	Peptidase family C69; Region: Peptidase_C69; pfam03577
1114965005683	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
1114965005684	MutS domain III; Region: MutS_III; pfam05192
1114965005685	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
1114965005686	Walker A/P-loop; other site
1114965005687	ATP binding site [chemical binding]; other site
1114965005688	Q-loop/lid; other site
1114965005689	ABC transporter signature motif; other site
1114965005690	Walker B; other site
1114965005691	D-loop; other site
1114965005692	H-loop/switch region; other site
1114965005693	Smr domain; Region: Smr; pfam01713
1114965005694	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
1114965005695	Colicin V production protein; Region: Colicin_V; pfam02674
1114965005696	ribonuclease HIII; Provisional; Region: PRK00996
1114965005697	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
1114965005698	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
1114965005699	RNA/DNA hybrid binding site [nucleotide binding]; other site
1114965005700	active site
1114965005701	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1114965005702	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1114965005703	Catalytic site [active]
1114965005704	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
1114965005705	AAA domain; Region: AAA_30; pfam13604
1114965005706	Family description; Region: UvrD_C_2; pfam13538
1114965005707	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1114965005708	active site
1114965005709	DNA polymerase IV; Validated; Region: PRK02406
1114965005710	DNA binding site [nucleotide binding]
1114965005711	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
1114965005712	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
1114965005713	Uncharacterized conserved protein [Function unknown]; Region: COG2966
1114965005714	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
1114965005715	Uncharacterized conserved protein [Function unknown]; Region: COG3610
1114965005716	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
1114965005717	3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835
1114965005718	dimer interface [polypeptide binding]; other site
1114965005719	active site
1114965005720	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
1114965005721	homodimer interface [polypeptide binding]; other site
1114965005722	catalytic residues [active]
1114965005723	NAD binding site [chemical binding]; other site
1114965005724	substrate binding pocket [chemical binding]; other site
1114965005725	flexible flap; other site
1114965005726	Protease prsW family; Region: PrsW-protease; pfam13367
1114965005727	Peptidase family C69; Region: Peptidase_C69; cl17793
1114965005728	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
1114965005729	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
1114965005730	homotetramer interface [polypeptide binding]; other site
1114965005731	FMN binding site [chemical binding]; other site
1114965005732	homodimer contacts [polypeptide binding]; other site
1114965005733	putative active site [active]
1114965005734	putative substrate binding site [chemical binding]; other site
1114965005735	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
1114965005736	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1114965005737	diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240
1114965005738	diphosphomevalonate decarboxylase; Region: PLN02407
1114965005739	diphosphomevalonate decarboxylase; Region: PLN02407
1114965005740	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
1114965005741	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
1114965005742	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1114965005743	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1114965005744	Beta-lactamase; Region: Beta-lactamase; pfam00144
1114965005745	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1114965005746	x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371
1114965005747	X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; pfam09168
1114965005748	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
1114965005749	HTH domain; Region: HTH_11; cl17392
1114965005750	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
1114965005751	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
1114965005752	active site
1114965005753	catalytic site [active]
1114965005754	substrate binding site [chemical binding]; other site
1114965005755	hypothetical protein; Validated; Region: PRK00153
1114965005756	integrase; Provisional; Region: int; PHA02601
1114965005757	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
1114965005758	Int/Topo IB signature motif; other site
1114965005759	Domain of unknown function (DUF3173); Region: DUF3173; pfam11372
1114965005760	Surface antigen [General function prediction only]; Region: COG3942
1114965005761	CHAP domain; Region: CHAP; pfam05257
1114965005762	AAA-like domain; Region: AAA_10; pfam12846
1114965005763	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1114965005764	Walker A motif; other site
1114965005765	ATP binding site [chemical binding]; other site
1114965005766	TcpE family; Region: TcpE; pfam12648
1114965005767	Conjugative transposon protein TcpC; Region: TpcC; pfam12642
1114965005768	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1114965005769	non-specific DNA binding site [nucleotide binding]; other site
1114965005770	salt bridge; other site
1114965005771	sequence-specific DNA binding site [nucleotide binding]; other site
1114965005772	Replication initiation factor; Region: Rep_trans; pfam02486
1114965005773	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1114965005774	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1114965005775	non-specific DNA binding site [nucleotide binding]; other site
1114965005776	salt bridge; other site
1114965005777	sequence-specific DNA binding site [nucleotide binding]; other site
1114965005778	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1114965005779	Domain of unknown function (DUF955); Region: DUF955; pfam06114
1114965005780	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
1114965005781	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1114965005782	non-specific DNA binding site [nucleotide binding]; other site
1114965005783	salt bridge; other site
1114965005784	sequence-specific DNA binding site [nucleotide binding]; other site
1114965005785	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1114965005786	Catalytic site [active]
1114965005787	bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654
1114965005788	Protein of unknown function (DUF1430); Region: DUF1430; pfam07242
1114965005789	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1114965005790	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
1114965005791	Walker A/P-loop; other site
1114965005792	ATP binding site [chemical binding]; other site
1114965005793	Q-loop/lid; other site
1114965005794	ABC transporter signature motif; other site
1114965005795	Walker B; other site
1114965005796	D-loop; other site
1114965005797	H-loop/switch region; other site
1114965005798	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1114965005799	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1114965005800	non-specific DNA binding site [nucleotide binding]; other site
1114965005801	salt bridge; other site
1114965005802	sequence-specific DNA binding site [nucleotide binding]; other site
1114965005803	Fic/DOC family; Region: Fic; cl00960
1114965005804	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1114965005805	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1114965005806	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1114965005807	Walker A/P-loop; other site
1114965005808	ATP binding site [chemical binding]; other site
1114965005809	Q-loop/lid; other site
1114965005810	ABC transporter signature motif; other site
1114965005811	Walker B; other site
1114965005812	D-loop; other site
1114965005813	H-loop/switch region; other site
1114965005814	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1114965005815	FeS/SAM binding site; other site
1114965005816	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1114965005817	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1114965005818	non-specific DNA binding site [nucleotide binding]; other site
1114965005819	salt bridge; other site
1114965005820	sequence-specific DNA binding site [nucleotide binding]; other site
1114965005821	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
1114965005822	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
1114965005823	HicB family; Region: HicB; pfam05534
1114965005824	LrgB-like family; Region: LrgB; pfam04172
1114965005825	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
1114965005826	HI0933-like protein; Region: HI0933_like; pfam03486
1114965005827	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
1114965005828	amphipathic channel; other site
1114965005829	Asn-Pro-Ala signature motifs; other site
1114965005830	Predicted membrane protein [Function unknown]; Region: COG4392
1114965005831	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
1114965005832	tandem five-transmembrane protein; Region: Gpos_tandem_5TM; TIGR01218
1114965005833	UGMP family protein; Validated; Region: PRK09604
1114965005834	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
1114965005835	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
1114965005836	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1114965005837	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1114965005838	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1114965005839	Glycoprotease family; Region: Peptidase_M22; pfam00814
1114965005840	hypothetical protein; Provisional; Region: PRK13667
1114965005841	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1114965005842	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
1114965005843	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1114965005844	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1114965005845	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1114965005846	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1114965005847	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
1114965005848	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1114965005849	DNA binding residues [nucleotide binding]
1114965005850	putative dimer interface [polypeptide binding]; other site
1114965005851	Predicted membrane protein [Function unknown]; Region: COG4129
1114965005852	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
1114965005853	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
1114965005854	Phosphoglycerate kinase; Region: PGK; pfam00162
1114965005855	substrate binding site [chemical binding]; other site
1114965005856	hinge regions; other site
1114965005857	ADP binding site [chemical binding]; other site
1114965005858	catalytic site [active]
1114965005859	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
1114965005860	Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724
1114965005861	Glycosyl hydrolase family 85; Region: Glyco_hydro_85; pfam03644
1114965005862	active site
1114965005863	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
1114965005864	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
1114965005865	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
1114965005866	Inclusion body protein; Region: PixA; pfam12306
1114965005867	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
1114965005868	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1114965005869	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1114965005870	elongation factor G; Reviewed; Region: PRK00007
1114965005871	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1114965005872	G1 box; other site
1114965005873	putative GEF interaction site [polypeptide binding]; other site
1114965005874	GTP/Mg2+ binding site [chemical binding]; other site
1114965005875	Switch I region; other site
1114965005876	G2 box; other site
1114965005877	G3 box; other site
1114965005878	Switch II region; other site
1114965005879	G4 box; other site
1114965005880	G5 box; other site
1114965005881	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1114965005882	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1114965005883	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1114965005884	30S ribosomal protein S7; Validated; Region: PRK05302
1114965005885	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
1114965005886	S17 interaction site [polypeptide binding]; other site
1114965005887	S8 interaction site; other site
1114965005888	16S rRNA interaction site [nucleotide binding]; other site
1114965005889	streptomycin interaction site [chemical binding]; other site
1114965005890	23S rRNA interaction site [nucleotide binding]; other site
1114965005891	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
1114965005892	pur operon repressor; Provisional; Region: PRK09213
1114965005893	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
1114965005894	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1114965005895	active site
1114965005896	Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481
1114965005897	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
1114965005898	generic binding surface II; other site
1114965005899	generic binding surface I; other site
1114965005900	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1114965005901	Zn2+ binding site [ion binding]; other site
1114965005902	Mg2+ binding site [ion binding]; other site
1114965005903	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
1114965005904	RmuC family; Region: RmuC; pfam02646
1114965005905	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
1114965005906	Thiamine pyrophosphokinase; Region: TPK; cd07995
1114965005907	active site
1114965005908	dimerization interface [polypeptide binding]; other site
1114965005909	thiamine binding site [chemical binding]; other site
1114965005910	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
1114965005911	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1114965005912	substrate binding site [chemical binding]; other site
1114965005913	hexamer interface [polypeptide binding]; other site
1114965005914	metal binding site [ion binding]; metal-binding site
1114965005915	GTPase RsgA; Reviewed; Region: PRK00098
1114965005916	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
1114965005917	RNA binding site [nucleotide binding]; other site
1114965005918	homodimer interface [polypeptide binding]; other site
1114965005919	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1114965005920	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1114965005921	GTP/Mg2+ binding site [chemical binding]; other site
1114965005922	G4 box; other site
1114965005923	G1 box; other site
1114965005924	Switch I region; other site
1114965005925	G2 box; other site
1114965005926	G3 box; other site
1114965005927	Switch II region; other site
1114965005928	CAAX protease self-immunity; Region: Abi; pfam02517
1114965005929	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
1114965005930	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1114965005931	S-adenosylmethionine binding site [chemical binding]; other site
1114965005932	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
1114965005933	putative active site [active]
1114965005934	putative metal binding site [ion binding]; other site
1114965005935	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
1114965005936	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1114965005937	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
1114965005938	active site
1114965005939	Ribosomal protein L34; Region: Ribosomal_L34; cl00370
1114965005940	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
1114965005941	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
1114965005942	G-X-X-G motif; other site
1114965005943	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
1114965005944	RxxxH motif; other site
1114965005945	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
1114965005946	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
1114965005947	ribonuclease P; Reviewed; Region: rnpA; PRK00499
1114965005948	CAAX protease self-immunity; Region: Abi; pfam02517
1114965005949	C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325
1114965005950	gating phenylalanine in ion channel; other site
1114965005951	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1114965005952	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1114965005953	accessory Sec system glycosyltransferase GtfB; Region: TIGR02919
1114965005954	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1114965005955	accessory Sec system glycosylation protein GtfA; Region: TIGR02918
1114965005956	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
1114965005957	accessory Sec system translocase SecA2; Region: secA2; TIGR03714
1114965005958	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1114965005959	ATP binding site [chemical binding]; other site
1114965005960	putative Mg++ binding site [ion binding]; other site
1114965005961	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
1114965005962	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1114965005963	nucleotide binding region [chemical binding]; other site
1114965005964	ATP-binding site [chemical binding]; other site
1114965005965	accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711
1114965005966	accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712
1114965005967	accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713
1114965005968	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1114965005969	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417
1114965005970	SecY translocase; Region: SecY; pfam00344
1114965005971	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
1114965005972	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1114965005973	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1114965005974	active site
1114965005975	glycosyltransferase, SP_1767 family; Region: glyco_access_1; TIGR03728
1114965005976	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1114965005977	active site
1114965005978	beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814
1114965005979	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1114965005980	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1114965005981	active site
1114965005982	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1114965005983	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1114965005984	active site
1114965005985	HIGH motif; other site
1114965005986	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1114965005987	active site
1114965005988	KMSKS motif; other site
1114965005989	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
1114965005990	Predicted esterase [General function prediction only]; Region: COG0627
1114965005991	S-formylglutathione hydrolase; Region: PLN02442
1114965005992	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1114965005993	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
1114965005994	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1114965005995	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
1114965005996	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1114965005997	Walker A/P-loop; other site
1114965005998	ATP binding site [chemical binding]; other site
1114965005999	Q-loop/lid; other site
1114965006000	ABC transporter signature motif; other site
1114965006001	Walker B; other site
1114965006002	D-loop; other site
1114965006003	H-loop/switch region; other site
1114965006004	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1114965006005	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
1114965006006	TM-ABC transporter signature motif; other site
1114965006007	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
1114965006008	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
1114965006009	T surface-antigen of pili; Region: FctA; pfam12892
1114965006010	T surface-antigen of pili; Region: FctA; pfam12892
1114965006011	T surface-antigen of pili; Region: FctA; pfam12892
1114965006012	T surface-antigen of pili; Region: FctA; pfam12892
1114965006013	T surface-antigen of pili; Region: FctA; cl16948
1114965006014	adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228
1114965006015	T surface-antigen of pili; Region: FctA; cl16948
1114965006016	adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228
1114965006017	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
1114965006018	adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228
1114965006019	T surface-antigen of pili; Region: FctA; cl16948
1114965006020	adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228
1114965006021	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
1114965006022	adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228
1114965006023	streptococcal pilin isopeptide linkage domain; Region: strep_pil_rpt; TIGR03786
1114965006024	adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228
1114965006025	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
1114965006026	active site clefts [active]
1114965006027	zinc binding site [ion binding]; other site
1114965006028	dimer interface [polypeptide binding]; other site
1114965006029	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1114965006030	DNA repair protein RadA; Provisional; Region: PRK11823
1114965006031	Walker A motif; other site
1114965006032	ATP binding site [chemical binding]; other site
1114965006033	Walker B motif; other site
1114965006034	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1114965006035	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1114965006036	catalytic core [active]
1114965006037	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1114965006038	trimer interface [polypeptide binding]; other site
1114965006039	active site
1114965006040	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
1114965006041	MucBP domain; Region: MucBP; pfam06458
1114965006042	MucBP domain; Region: MucBP; pfam06458
1114965006043	MucBP domain; Region: MucBP; pfam06458
1114965006044	MucBP domain; Region: MucBP; pfam06458
1114965006045	MucBP domain; Region: MucBP; pfam06458
1114965006046	MucBP domain; Region: MucBP; pfam06458
1114965006047	MucBP domain; Region: MucBP; pfam06458
1114965006048	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
1114965006049	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
1114965006050	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
1114965006051	catalytic triad [active]
1114965006052	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
1114965006053	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1114965006054	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1114965006055	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1114965006056	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1114965006057	active site
1114965006058	tetramer interface; other site
1114965006059	Peptidase family C69; Region: Peptidase_C69; pfam03577
1114965006060	Rhomboid family; Region: Rhomboid; pfam01694
1114965006061	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
1114965006062	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
1114965006063	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1114965006064	M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670
1114965006065	metal binding site [ion binding]; metal-binding site
1114965006066	putative dimer interface [polypeptide binding]; other site
1114965006067	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
1114965006068	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
1114965006069	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
1114965006070	trimer interface [polypeptide binding]; other site
1114965006071	active site
1114965006072	substrate binding site [chemical binding]; other site
1114965006073	CoA binding site [chemical binding]; other site
1114965006074	Transposase IS200 like; Region: Y1_Tnp; pfam01797
1114965006075	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
1114965006076	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
1114965006077	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1114965006078	active site
1114965006079	dimer interface [polypeptide binding]; other site
1114965006080	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1114965006081	dimer interface [polypeptide binding]; other site
1114965006082	active site
1114965006083	Transposase; Region: DEDD_Tnp_IS110; pfam01548
1114965006084	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1114965006085	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1114965006086	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1114965006087	nucleoside/Zn binding site; other site
1114965006088	dimer interface [polypeptide binding]; other site
1114965006089	catalytic motif [active]
1114965006090	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1114965006091	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1114965006092	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1114965006093	Walker A/P-loop; other site
1114965006094	ATP binding site [chemical binding]; other site
1114965006095	Q-loop/lid; other site
1114965006096	ABC transporter signature motif; other site
1114965006097	Walker B; other site
1114965006098	D-loop; other site
1114965006099	H-loop/switch region; other site
1114965006100	Radical SAM superfamily; Region: Radical_SAM; pfam04055
1114965006101	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1114965006102	FeS/SAM binding site; other site
1114965006103	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
1114965006104	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1114965006105	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1114965006106	motif II; other site
1114965006107	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1114965006108	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1114965006109	GDP-binding site [chemical binding]; other site
1114965006110	ACT binding site; other site
1114965006111	IMP binding site; other site
1114965006112	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
1114965006113	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
1114965006114	dimerization interface [polypeptide binding]; other site
1114965006115	domain crossover interface; other site
1114965006116	redox-dependent activation switch; other site
1114965006117	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
1114965006118	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1114965006119	FMN binding site [chemical binding]; other site
1114965006120	active site
1114965006121	catalytic residues [active]
1114965006122	substrate binding site [chemical binding]; other site
1114965006123	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
1114965006124	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
1114965006125	nudix motif; other site
1114965006126	nicotinamide mononucleotide transporter PnuC; Region: NMN_trans_PnuC; TIGR01528
1114965006127	nicotinamide-nucleotide adenylyltransferase, NadR type; Region: nadR_NMN_Atrans; TIGR01526
1114965006128	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1114965006129	active site
1114965006130	nucleotide binding site [chemical binding]; other site
1114965006131	HIGH motif; other site
1114965006132	KMSKS motif; other site
1114965006133	Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172
1114965006134	Ubiquitin-like proteins; Region: UBQ; cl00155
1114965006135	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
1114965006136	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1114965006137	Walker A motif; other site
1114965006138	ATP binding site [chemical binding]; other site
1114965006139	Walker B motif; other site
1114965006140	arginine finger; other site
1114965006141	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1114965006142	Walker A motif; other site
1114965006143	ATP binding site [chemical binding]; other site
1114965006144	Walker B motif; other site
1114965006145	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1114965006146	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848
1114965006147	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
1114965006148	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
1114965006149	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
1114965006150	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
1114965006151	Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880
1114965006152	Calx-beta domain; Region: Calx-beta; cl02522
1114965006153	G5 domain; Region: G5; pfam07501
1114965006154	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
1114965006155	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
1114965006156	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
1114965006157	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
1114965006158	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
1114965006159	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
1114965006160	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
1114965006161	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
1114965006162	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
1114965006163	G5 domain; Region: G5; pfam07501
1114965006164	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
1114965006165	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
1114965006166	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1114965006167	dimerization interface [polypeptide binding]; other site
1114965006168	DPS ferroxidase diiron center [ion binding]; other site
1114965006169	ion pore; other site
1114965006170	Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695
1114965006171	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1114965006172	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1114965006173	dimerization interface [polypeptide binding]; other site
1114965006174	putative Zn2+ binding site [ion binding]; other site
1114965006175	putative DNA binding site [nucleotide binding]; other site
1114965006176	Transposase; Region: HTH_Tnp_1; cl17663
1114965006177	HTH-like domain; Region: HTH_21; pfam13276
1114965006178	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
1114965006179	Integrase core domain; Region: rve; pfam00665
1114965006180	Integrase core domain; Region: rve_2; pfam13333
1114965006181	elongation factor Ts; Provisional; Region: tsf; PRK09377
1114965006182	UBA/TS-N domain; Region: UBA; pfam00627
1114965006183	Elongation factor TS; Region: EF_TS; pfam00889
1114965006184	Elongation factor TS; Region: EF_TS; pfam00889
1114965006185	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1114965006186	rRNA interaction site [nucleotide binding]; other site
1114965006187	S8 interaction site; other site
1114965006188	putative laminin-1 binding site; other site
1114965006189	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1114965006190	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1114965006191	putative homodimer interface [polypeptide binding]; other site
1114965006192	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1114965006193	heterodimer interface [polypeptide binding]; other site
1114965006194	homodimer interface [polypeptide binding]; other site
1114965006195	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
1114965006196	Transposase; Region: DDE_Tnp_ISL3; pfam01610
1114965006197	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
1114965006198	Predicted metalloprotease [General function prediction only]; Region: COG2321
1114965006199	Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228
1114965006200	Transglycosylase; Region: Transgly; pfam00912
1114965006201	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1114965006202	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1114965006203	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1114965006204	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1114965006205	active site
1114965006206	AtlA is an autolysin found in Gram-positive lactic acid bacteria that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. This family includes the AtlA and Aml...; Region: GH25_AtlA-like; cd06522
1114965006207	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
1114965006208	active site
1114965006209	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
1114965006210	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
1114965006211	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
1114965006212	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
1114965006213	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
1114965006214	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
1114965006215	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
1114965006216	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
1114965006217	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1114965006218	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
1114965006219	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
1114965006220	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG5610
1114965006221	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
1114965006222	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
1114965006223	active site
1114965006224	homodimer interface [polypeptide binding]; other site
1114965006225	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1114965006226	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
1114965006227	Probable Catalytic site; other site
1114965006228	metal-binding site
1114965006229	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
1114965006230	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1114965006231	putative homodimer interface [polypeptide binding]; other site
1114965006232	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1114965006233	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1114965006234	active site
1114965006235	LicD family; Region: LicD; pfam04991
1114965006236	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
1114965006237	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
1114965006238	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
1114965006239	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1114965006240	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
1114965006241	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1114965006242	Chain length determinant protein; Region: Wzz; cl15801
1114965006243	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
1114965006244	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
1114965006245	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816
1114965006246	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
1114965006247	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1114965006248	FeS/SAM binding site; other site
1114965006249	Predicted acetyltransferase [General function prediction only]; Region: COG3981
1114965006250	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1114965006251	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
1114965006252	ATP cone domain; Region: ATP-cone; pfam03477
1114965006253	Class III ribonucleotide reductase; Region: RNR_III; cd01675
1114965006254	effector binding site; other site
1114965006255	active site
1114965006256	Zn binding site [ion binding]; other site
1114965006257	glycine loop; other site
1114965006258	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1114965006259	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
1114965006260	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
1114965006261	Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154
1114965006262	putative active site [active]
1114965006263	catalytic site [active]
1114965006264	Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160
1114965006265	putative active site [active]
1114965006266	catalytic site [active]
1114965006267	Bacterial lipoprotein; Region: DUF3642; pfam12182
1114965006268	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
1114965006269	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1114965006270	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1114965006271	hypothetical protein; Provisional; Region: PRK13678
1114965006272	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
1114965006273	hypothetical protein; Provisional; Region: PRK05473
1114965006274	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
1114965006275	ArsC family; Region: ArsC; pfam03960
1114965006276	putative catalytic residues [active]
1114965006277	thiol/disulfide switch; other site
1114965006278	recombinase A; Provisional; Region: recA; PRK09354
1114965006279	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
1114965006280	hexamer interface [polypeptide binding]; other site
1114965006281	Walker A motif; other site
1114965006282	ATP binding site [chemical binding]; other site
1114965006283	Walker B motif; other site
1114965006284	competence damage-inducible protein A; Provisional; Region: PRK00549
1114965006285	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
1114965006286	putative MPT binding site; other site
1114965006287	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
1114965006288	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
1114965006289	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
1114965006290	RuvA N terminal domain; Region: RuvA_N; pfam01330
1114965006291	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
1114965006292	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1114965006293	ATP binding site [chemical binding]; other site
1114965006294	Mg2+ binding site [ion binding]; other site
1114965006295	G-X-G motif; other site
1114965006296	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
1114965006297	ATP binding site [chemical binding]; other site
1114965006298	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
1114965006299	LytTr DNA-binding domain; Region: LytTR; smart00850
1114965006300	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
1114965006301	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
1114965006302	MutS domain I; Region: MutS_I; pfam01624
1114965006303	MutS domain II; Region: MutS_II; pfam05188
1114965006304	MutS domain III; Region: MutS_III; pfam05192
1114965006305	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
1114965006306	Walker A/P-loop; other site
1114965006307	ATP binding site [chemical binding]; other site
1114965006308	Q-loop/lid; other site
1114965006309	ABC transporter signature motif; other site
1114965006310	Walker B; other site
1114965006311	D-loop; other site
1114965006312	H-loop/switch region; other site
1114965006313	Arginine repressor [Transcription]; Region: ArgR; COG1438
1114965006314	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
1114965006315	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
1114965006316	arginyl-tRNA synthetase; Reviewed; Region: PRK12451
1114965006317	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
1114965006318	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1114965006319	active site
1114965006320	HIGH motif; other site
1114965006321	KMSK motif region; other site
1114965006322	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
1114965006323	tRNA binding surface [nucleotide binding]; other site
1114965006324	anticodon binding site; other site
1114965006325	flavoprotein NrdI; Provisional; Region: PRK02551
1114965006326	Glucan-binding protein C; Region: GbpC; pfam08363
1114965006327	Glucan-binding protein C; Region: GbpC; pfam08363
1114965006328	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1114965006329	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
1114965006330	4-alpha-glucanotransferase; Provisional; Region: PRK14508
1114965006331	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
1114965006332	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1114965006333	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1114965006334	dimer interface [polypeptide binding]; other site
1114965006335	conserved gate region; other site
1114965006336	putative PBP binding loops; other site
1114965006337	ABC-ATPase subunit interface; other site
1114965006338	potential frameshift: common BLAST hit: gi|337282909|ref|YP_004622380.1| maltodextrin ABC transporter membrane protein
1114965006339	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1114965006340	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1114965006341	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1114965006342	dimer interface [polypeptide binding]; other site
1114965006343	conserved gate region; other site
1114965006344	ABC-ATPase subunit interface; other site
1114965006345	Predicted integral membrane protein [Function unknown]; Region: COG5521
1114965006346	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1114965006347	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1114965006348	DNA binding site [nucleotide binding]
1114965006349	domain linker motif; other site
1114965006350	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1114965006351	pullulanase, type I; Region: pulA_typeI; TIGR02104
1114965006352	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
1114965006353	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
1114965006354	Ca binding site [ion binding]; other site
1114965006355	active site
1114965006356	catalytic site [active]
1114965006357	Uncharacterized conserved protein [Function unknown]; Region: COG1284
1114965006358	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1114965006359	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
1114965006360	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
1114965006361	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1114965006362	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1114965006363	dimer interface [polypeptide binding]; other site
1114965006364	anticodon binding site; other site
1114965006365	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1114965006366	homodimer interface [polypeptide binding]; other site
1114965006367	motif 1; other site
1114965006368	active site
1114965006369	motif 2; other site
1114965006370	GAD domain; Region: GAD; pfam02938
1114965006371	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
1114965006372	motif 3; other site
1114965006373	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966
1114965006374	DltD N-terminal region; Region: DltD_N; pfam04915
1114965006375	DltD central region; Region: DltD_M; pfam04918
1114965006376	DltD C-terminal region; Region: DltD_C; pfam04914
1114965006377	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087
1114965006378	D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091
1114965006379	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
1114965006380	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
1114965006381	acyl-activating enzyme (AAE) consensus motif; other site
1114965006382	AMP binding site [chemical binding]; other site
1114965006383	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
1114965006384	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
1114965006385	Active site serine [active]
1114965006386	Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750
1114965006387	putative metal binding residues [ion binding]; other site
1114965006388	signature motif; other site
1114965006389	dimer interface [polypeptide binding]; other site
1114965006390	active site
1114965006391	polyP binding site; other site
1114965006392	substrate binding site [chemical binding]; other site
1114965006393	acceptor-phosphate pocket; other site
1114965006394	Domain of unknown function (DUF4353); Region: DUF4353; pfam14262
1114965006395	Predicted membrane protein [Function unknown]; Region: COG1511
1114965006396	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
1114965006397	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
1114965006398	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
1114965006399	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1114965006400	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1114965006401	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1114965006402	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1114965006403	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1114965006404	RNA binding surface [nucleotide binding]; other site
1114965006405	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1114965006406	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1114965006407	Walker A/P-loop; other site
1114965006408	ATP binding site [chemical binding]; other site
1114965006409	Q-loop/lid; other site
1114965006410	ABC transporter signature motif; other site
1114965006411	Walker B; other site
1114965006412	D-loop; other site
1114965006413	H-loop/switch region; other site
1114965006414	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
1114965006415	NMT1/THI5 like; Region: NMT1; pfam09084
1114965006416	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1114965006417	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1114965006418	dimer interface [polypeptide binding]; other site
1114965006419	conserved gate region; other site
1114965006420	putative PBP binding loops; other site
1114965006421	ABC-ATPase subunit interface; other site
1114965006422	Protein of unknown function (DUF1021); Region: DUF1021; cl01852
1114965006423	replicative DNA helicase; Provisional; Region: PRK05748
1114965006424	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1114965006425	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1114965006426	Walker A motif; other site
1114965006427	ATP binding site [chemical binding]; other site
1114965006428	Walker B motif; other site
1114965006429	DNA binding loops [nucleotide binding]
1114965006430	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
1114965006431	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1114965006432	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1114965006433	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
1114965006434	DHH family; Region: DHH; pfam01368
1114965006435	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
1114965006436	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
1114965006437	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
1114965006438	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
1114965006439	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688
1114965006440	nudix motif; other site
1114965006441	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
1114965006442	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1114965006443	Ligand Binding Site [chemical binding]; other site
1114965006444	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1114965006445	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
1114965006446	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1114965006447	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
1114965006448	putative L-serine binding site [chemical binding]; other site
1114965006449	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
1114965006450	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
1114965006451	Eukaryotic phosphomannomutase; Region: PMM; cl17107
1114965006452	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1114965006453	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1114965006454	motif II; other site
1114965006455	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1114965006456	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
1114965006457	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
1114965006458	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13649
1114965006459	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1114965006460	Walker A/P-loop; other site
1114965006461	ATP binding site [chemical binding]; other site
1114965006462	Q-loop/lid; other site
1114965006463	ABC transporter signature motif; other site
1114965006464	Walker B; other site
1114965006465	D-loop; other site
1114965006466	H-loop/switch region; other site
1114965006467	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13650
1114965006468	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1114965006469	Walker A/P-loop; other site
1114965006470	ATP binding site [chemical binding]; other site
1114965006471	Q-loop/lid; other site
1114965006472	ABC transporter signature motif; other site
1114965006473	Walker B; other site
1114965006474	D-loop; other site
1114965006475	H-loop/switch region; other site
1114965006476	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
1114965006477	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
1114965006478	Helix-turn-helix domain; Region: HTH_25; pfam13413
1114965006479	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1114965006480	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1114965006481	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1114965006482	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1114965006483	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1114965006484	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1114965006485	RNA binding surface [nucleotide binding]; other site
1114965006486	recombination protein F; Reviewed; Region: recF; PRK00064
1114965006487	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
1114965006488	Walker A/P-loop; other site
1114965006489	ATP binding site [chemical binding]; other site
1114965006490	Q-loop/lid; other site
1114965006491	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1114965006492	ABC transporter signature motif; other site
1114965006493	Walker B; other site
1114965006494	D-loop; other site
1114965006495	H-loop/switch region; other site
1114965006496	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
1114965006497	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1114965006498	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
1114965006499	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1114965006500	active site
1114965006501	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1114965006502	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1114965006503	active site
1114965006504	HIGH motif; other site
1114965006505	dimer interface [polypeptide binding]; other site
1114965006506	KMSKS motif; other site
1114965006507	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
1114965006508	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1114965006509	Walker A/P-loop; other site
1114965006510	ATP binding site [chemical binding]; other site
1114965006511	Q-loop/lid; other site
1114965006512	ABC transporter signature motif; other site
1114965006513	Walker B; other site
1114965006514	D-loop; other site
1114965006515	H-loop/switch region; other site
1114965006516	ABC transporter; Region: ABC_tran_2; pfam12848
1114965006517	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1114965006518	Predicted membrane protein [Function unknown]; Region: COG4485
1114965006519	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
1114965006520	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1114965006521	active site
1114965006522	phosphorylation site [posttranslational modification]
1114965006523	intermolecular recognition site; other site
1114965006524	dimerization interface [polypeptide binding]; other site
1114965006525	LytTr DNA-binding domain; Region: LytTR; pfam04397
1114965006526	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
1114965006527	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1114965006528	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
1114965006529	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
1114965006530	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1114965006531	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1114965006532	protein binding site [polypeptide binding]; other site
1114965006533	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
1114965006534	ParB-like nuclease domain; Region: ParBc; pfam02195