-- dump date   	20140620_083824
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
981540000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
981540000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
981540000003	Walker A motif; other site
981540000004	ATP binding site [chemical binding]; other site
981540000005	Walker B motif; other site
981540000006	arginine finger; other site
981540000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
981540000008	DnaA box-binding interface [nucleotide binding]; other site
981540000009	DNA polymerase III subunit beta; Validated; Region: PRK05643
981540000010	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
981540000011	putative DNA binding surface [nucleotide binding]; other site
981540000012	dimer interface [polypeptide binding]; other site
981540000013	beta-clamp/clamp loader binding surface; other site
981540000014	beta-clamp/translesion DNA polymerase binding surface; other site
981540000015	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
981540000016	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
981540000017	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
981540000018	GTP-binding protein YchF; Reviewed; Region: PRK09601
981540000019	YchF GTPase; Region: YchF; cd01900
981540000020	G1 box; other site
981540000021	GTP/Mg2+ binding site [chemical binding]; other site
981540000022	Switch I region; other site
981540000023	G2 box; other site
981540000024	Switch II region; other site
981540000025	G3 box; other site
981540000026	G4 box; other site
981540000027	G5 box; other site
981540000028	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
981540000029	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
981540000030	putative active site [active]
981540000031	catalytic residue [active]
981540000032	superfamily II helicase; truncated transcription-repair coupling factor
981540000033	superfamily II helicase; truncated transcription-repair coupling factor
981540000034	truncated bacteriophage CI transcriptional regulator
981540000035	truncated bacteriophage CI transcriptional regulator
981540000036	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
981540000037	RNA binding surface [nucleotide binding]; other site
981540000038	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
981540000039	Septum formation initiator; Region: DivIC; pfam04977
981540000040	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
981540000041	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
981540000042	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
981540000043	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
981540000044	Ligand Binding Site [chemical binding]; other site
981540000045	TilS substrate C-terminal domain; Region: TilS_C; smart00977
981540000046	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
981540000047	active site
981540000048	ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465
981540000049	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
981540000050	Walker A motif; other site
981540000051	ATP binding site [chemical binding]; other site
981540000052	Walker B motif; other site
981540000053	arginine finger; other site
981540000054	Peptidase family M41; Region: Peptidase_M41; pfam01434
981540000055	truncated IS150-like transposase
981540000056	rod shape-determining protein MreC; Provisional; Region: PRK13922
981540000057	rod shape-determining protein MreC; Region: MreC; pfam04085
981540000058	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
981540000059	Septum formation initiator; Region: DivIC; cl17659
981540000060	CHAP domain; Region: CHAP; pfam05257
981540000061	Surface antigen [General function prediction only]; Region: COG3942
981540000062	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269
981540000063	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
981540000064	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
981540000065	active site
981540000066	aromatic amino acid aminotransferase; Validated; Region: PRK07309
981540000067	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
981540000068	pyridoxal 5'-phosphate binding site [chemical binding]; other site
981540000069	homodimer interface [polypeptide binding]; other site
981540000070	catalytic residue [active]
981540000071	Recombination protein O N terminal; Region: RecO_N; pfam11967
981540000072	DNA repair protein RecO; Region: reco; TIGR00613
981540000073	Recombination protein O C terminal; Region: RecO_C; pfam02565
981540000074	putative phosphate acyltransferase; Provisional; Region: PRK05331
981540000075	acyl carrier protein; Provisional; Region: PRK12449
981540000076	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
981540000077	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
981540000078	ATP binding site [chemical binding]; other site
981540000079	active site
981540000080	substrate binding site [chemical binding]; other site
981540000081	phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857
981540000082	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
981540000083	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
981540000084	dimerization interface [polypeptide binding]; other site
981540000085	ATP binding site [chemical binding]; other site
981540000086	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
981540000087	dimerization interface [polypeptide binding]; other site
981540000088	ATP binding site [chemical binding]; other site
981540000089	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
981540000090	putative active site [active]
981540000091	catalytic triad [active]
981540000092	amidophosphoribosyltransferase; Provisional; Region: PRK07272
981540000093	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
981540000094	active site
981540000095	tetramer interface [polypeptide binding]; other site
981540000096	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
981540000097	active site
981540000098	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
981540000099	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
981540000100	dimerization interface [polypeptide binding]; other site
981540000101	putative ATP binding site [chemical binding]; other site
981540000102	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
981540000103	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
981540000104	active site
981540000105	substrate binding site [chemical binding]; other site
981540000106	cosubstrate binding site; other site
981540000107	catalytic site [active]
981540000108	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
981540000109	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
981540000110	purine monophosphate binding site [chemical binding]; other site
981540000111	dimer interface [polypeptide binding]; other site
981540000112	putative catalytic residues [active]
981540000113	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
981540000114	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
981540000115	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
981540000116	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
981540000117	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
981540000118	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
981540000119	Protein of unknown function (DUF523); Region: DUF523; pfam04463
981540000120	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
981540000121	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
981540000122	ATP-grasp domain; Region: ATP-grasp; pfam02222
981540000123	adenylosuccinate lyase; Provisional; Region: PRK07492
981540000124	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
981540000125	tetramer interface [polypeptide binding]; other site
981540000126	active site
981540000127	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
981540000128	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
981540000129	non-specific DNA binding site [nucleotide binding]; other site
981540000130	salt bridge; other site
981540000131	sequence-specific DNA binding site [nucleotide binding]; other site
981540000132	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
981540000133	Low molecular weight phosphatase family; Region: LMWPc; cd00115
981540000134	active site
981540000135	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
981540000136	MORN repeat; Region: MORN; cl14787
981540000137	Acyltransferase family; Region: Acyl_transf_3; pfam01757
981540000138	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
981540000139	active site
981540000140	catalytic triad [active]
981540000141	oxyanion hole [active]
981540000142	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
981540000143	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
981540000144	pyridoxal 5'-phosphate binding site [chemical binding]; other site
981540000145	catalytic residue [active]
981540000146	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
981540000147	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
981540000148	truncated LysR family transcriptional regulator
981540000149	hypothetical protein
981540000150	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
981540000151	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
981540000152	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
981540000153	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
981540000154	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
981540000155	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
981540000156	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
981540000157	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
981540000158	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
981540000159	putative translocon binding site; other site
981540000160	protein-rRNA interface [nucleotide binding]; other site
981540000161	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
981540000162	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
981540000163	G-X-X-G motif; other site
981540000164	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
981540000165	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
981540000166	23S rRNA interface [nucleotide binding]; other site
981540000167	5S rRNA interface [nucleotide binding]; other site
981540000168	putative antibiotic binding site [chemical binding]; other site
981540000169	L25 interface [polypeptide binding]; other site
981540000170	L27 interface [polypeptide binding]; other site
981540000171	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
981540000172	23S rRNA interface [nucleotide binding]; other site
981540000173	putative translocon interaction site; other site
981540000174	signal recognition particle (SRP54) interaction site; other site
981540000175	L23 interface [polypeptide binding]; other site
981540000176	trigger factor interaction site; other site
981540000177	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
981540000178	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
981540000179	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
981540000180	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
981540000181	RNA binding site [nucleotide binding]; other site
981540000182	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
981540000183	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
981540000184	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
981540000185	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
981540000186	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
981540000187	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
981540000188	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
981540000189	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
981540000190	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
981540000191	5S rRNA interface [nucleotide binding]; other site
981540000192	L27 interface [polypeptide binding]; other site
981540000193	23S rRNA interface [nucleotide binding]; other site
981540000194	L5 interface [polypeptide binding]; other site
981540000195	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
981540000196	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
981540000197	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
981540000198	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
981540000199	23S rRNA binding site [nucleotide binding]; other site
981540000200	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
981540000201	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
981540000202	SecY translocase; Region: SecY; pfam00344
981540000203	adenylate kinase; Reviewed; Region: adk; PRK00279
981540000204	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
981540000205	AMP-binding site [chemical binding]; other site
981540000206	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
981540000207	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
981540000208	rRNA binding site [nucleotide binding]; other site
981540000209	predicted 30S ribosome binding site; other site
981540000210	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
981540000211	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
981540000212	30S ribosomal protein S13; Region: bact_S13; TIGR03631
981540000213	30S ribosomal protein S11; Validated; Region: PRK05309
981540000214	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
981540000215	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
981540000216	alphaNTD homodimer interface [polypeptide binding]; other site
981540000217	alphaNTD - beta interaction site [polypeptide binding]; other site
981540000218	alphaNTD - beta' interaction site [polypeptide binding]; other site
981540000219	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
981540000220	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
981540000221	truncated transposase IS1239
981540000222	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
981540000223	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
981540000224	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
981540000225	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
981540000226	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
981540000227	putative Zn2+ binding site [ion binding]; other site
981540000228	putative DNA binding site [nucleotide binding]; other site
981540000229	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
981540000230	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
981540000231	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
981540000232	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
981540000233	ABC-ATPase subunit  interface; other site
981540000234	dimer interface [polypeptide binding]; other site
981540000235	putative PBP binding regions; other site
981540000236	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
981540000237	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
981540000238	active site
981540000239	HIGH motif; other site
981540000240	dimer interface [polypeptide binding]; other site
981540000241	KMSKS motif; other site
981540000242	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
981540000243	RNA binding surface [nucleotide binding]; other site
981540000244	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
981540000245	Transglycosylase; Region: Transgly; pfam00912
981540000246	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
981540000247	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
981540000248	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
981540000249	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
981540000250	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
981540000251	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
981540000252	RPB1 interaction site [polypeptide binding]; other site
981540000253	RPB12 interaction site [polypeptide binding]; other site
981540000254	RPB10 interaction site [polypeptide binding]; other site
981540000255	RPB11 interaction site [polypeptide binding]; other site
981540000256	RPB3 interaction site [polypeptide binding]; other site
981540000257	RPB12 interaction site [polypeptide binding]; other site
981540000258	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
981540000259	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
981540000260	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
981540000261	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
981540000262	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
981540000263	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
981540000264	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
981540000265	G-loop; other site
981540000266	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
981540000267	DNA binding site [nucleotide binding]
981540000268	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
981540000269	Protein of unknown function (DUF1033); Region: DUF1033; pfam06279
981540000270	Type II/IV secretion system protein; Region: T2SE; pfam00437
981540000271	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
981540000272	Walker A motif; other site
981540000273	ATP binding site [chemical binding]; other site
981540000274	Walker B motif; other site
981540000275	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
981540000276	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
981540000277	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
981540000278	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
981540000279	Type II secretory pathway pseudopilin; Region: PulG; pfam11773
981540000280	Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940
981540000281	Methyltransferase domain; Region: Methyltransf_31; pfam13847
981540000282	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
981540000283	S-adenosylmethionine binding site [chemical binding]; other site
981540000284	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
981540000285	propionate/acetate kinase; Provisional; Region: PRK12379
981540000286	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
981540000287	non-specific DNA binding site [nucleotide binding]; other site
981540000288	salt bridge; other site
981540000289	sequence-specific DNA binding site [nucleotide binding]; other site
981540000290	CAAX protease self-immunity; Region: Abi; pfam02517
981540000291	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
981540000292	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
981540000293	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
981540000294	glutamyl aminopeptidase; Region: glu_aminopep; TIGR03107
981540000295	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
981540000296	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
981540000297	Coenzyme A binding pocket [chemical binding]; other site
981540000298	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
981540000299	catalytic residues [active]
981540000300	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
981540000301	putative tRNA-binding site [nucleotide binding]; other site
981540000302	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
981540000303	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
981540000304	dimer interface [polypeptide binding]; other site
981540000305	ssDNA binding site [nucleotide binding]; other site
981540000306	tetramer (dimer of dimers) interface [polypeptide binding]; other site
981540000307	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
981540000308	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
981540000309	active site
981540000310	motif I; other site
981540000311	motif II; other site
981540000312	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
981540000313	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
981540000314	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
981540000315	ligand binding site [chemical binding]; other site
981540000316	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
981540000317	Histidine kinase; Region: HisKA_3; pfam07730
981540000318	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
981540000319	ATP binding site [chemical binding]; other site
981540000320	Mg2+ binding site [ion binding]; other site
981540000321	G-X-G motif; other site
981540000322	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
981540000323	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
981540000324	active site
981540000325	phosphorylation site [posttranslational modification]
981540000326	intermolecular recognition site; other site
981540000327	dimerization interface [polypeptide binding]; other site
981540000328	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
981540000329	DNA binding residues [nucleotide binding]
981540000330	dimerization interface [polypeptide binding]; other site
981540000331	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
981540000332	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
981540000333	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
981540000334	active pocket/dimerization site; other site
981540000335	active site
981540000336	phosphorylation site [posttranslational modification]
981540000337	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cl00021
981540000338	active site
981540000339	phosphorylation site [posttranslational modification]
981540000340	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
981540000341	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
981540000342	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
981540000343	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
981540000344	zinc binding site [ion binding]; other site
981540000345	putative ligand binding site [chemical binding]; other site
981540000346	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
981540000347	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
981540000348	TM-ABC transporter signature motif; other site
981540000349	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
981540000350	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
981540000351	Walker A/P-loop; other site
981540000352	ATP binding site [chemical binding]; other site
981540000353	Q-loop/lid; other site
981540000354	ABC transporter signature motif; other site
981540000355	Walker B; other site
981540000356	D-loop; other site
981540000357	H-loop/switch region; other site
981540000358	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
981540000359	oligomerisation interface [polypeptide binding]; other site
981540000360	mobile loop; other site
981540000361	roof hairpin; other site
981540000362	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
981540000363	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
981540000364	ring oligomerisation interface [polypeptide binding]; other site
981540000365	ATP/Mg binding site [chemical binding]; other site
981540000366	stacking interactions; other site
981540000367	hinge regions; other site
981540000368	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
981540000369	non-specific DNA binding site [nucleotide binding]; other site
981540000370	salt bridge; other site
981540000371	sequence-specific DNA binding site [nucleotide binding]; other site
981540000372	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
981540000373	Predicted membrane protein [Function unknown]; Region: COG4640
981540000374	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
981540000375	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
981540000376	active site
981540000377	Transglycosylase; Region: Transgly; pfam00912
981540000378	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
981540000379	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
981540000380	Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690
981540000381	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
981540000382	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
981540000383	putative homodimer interface [polypeptide binding]; other site
981540000384	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
981540000385	heterodimer interface [polypeptide binding]; other site
981540000386	homodimer interface [polypeptide binding]; other site
981540000387	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
981540000388	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
981540000389	active site
981540000390	nucleophile elbow; other site
981540000391	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
981540000392	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
981540000393	HIGH motif; other site
981540000394	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
981540000395	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
981540000396	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
981540000397	active site
981540000398	KMSKS motif; other site
981540000399	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
981540000400	tRNA binding surface [nucleotide binding]; other site
981540000401	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
981540000402	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
981540000403	active site
981540000404	catalytic residues [active]
981540000405	recombination factor protein RarA; Reviewed; Region: PRK13342
981540000406	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
981540000407	Walker A motif; other site
981540000408	ATP binding site [chemical binding]; other site
981540000409	Walker B motif; other site
981540000410	arginine finger; other site
981540000411	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
981540000412	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
981540000413	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
981540000414	Coenzyme A binding pocket [chemical binding]; other site
981540000415	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
981540000416	Protein of unknown function (DUF3013); Region: DUF3013; pfam11217
981540000417	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
981540000418	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
981540000419	S-adenosylmethionine binding site [chemical binding]; other site
981540000420	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
981540000421	RNA methyltransferase, RsmE family; Region: TIGR00046
981540000422	Transcriptional regulators [Transcription]; Region: PurR; COG1609
981540000423	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
981540000424	DNA binding site [nucleotide binding]
981540000425	domain linker motif; other site
981540000426	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
981540000427	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
981540000428	PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003
981540000429	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
981540000430	active site turn [active]
981540000431	phosphorylation site [posttranslational modification]
981540000432	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
981540000433	HPr interaction site; other site
981540000434	glycerol kinase (GK) interaction site [polypeptide binding]; other site
981540000435	active site
981540000436	phosphorylation site [posttranslational modification]
981540000437	Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079
981540000438	putative catalytic site [active]
981540000439	putative metal binding site [ion binding]; other site
981540000440	putative phosphate binding site [ion binding]; other site
981540000441	DpnD/PcfM-like protein; Region: DpnD-PcfM; pfam14207
981540000442	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
981540000443	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
981540000444	putative oligomer interface [polypeptide binding]; other site
981540000445	putative active site [active]
981540000446	metal binding site [ion binding]; metal-binding site
981540000447	flavoprotein NrdI; Provisional; Region: PRK02551
981540000448	cellobiose phosphotransferase system IIB component; Reviewed; Region: celB; PRK09590
981540000449	active site
981540000450	P-loop; other site
981540000451	phosphorylation site [posttranslational modification]
981540000452	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
981540000453	methionine cluster; other site
981540000454	active site
981540000455	phosphorylation site [posttranslational modification]
981540000456	metal binding site [ion binding]; metal-binding site
981540000457	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
981540000458	beta-galactosidase; Region: BGL; TIGR03356
981540000459	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
981540000460	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
981540000461	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
981540000462	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
981540000463	DNA-binding site [nucleotide binding]; DNA binding site
981540000464	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
981540000465	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
981540000466	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
981540000467	truncated aspartate 1-decarboxylase
981540000468	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
981540000469	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
981540000470	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
981540000471	dimer interface [polypeptide binding]; other site
981540000472	conserved gate region; other site
981540000473	putative PBP binding loops; other site
981540000474	ABC-ATPase subunit interface; other site
981540000475	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
981540000476	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
981540000477	dimer interface [polypeptide binding]; other site
981540000478	conserved gate region; other site
981540000479	ABC-ATPase subunit interface; other site
981540000480	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
981540000481	Melibiase; Region: Melibiase; pfam02065
981540000482	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
981540000483	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
981540000484	DNA-binding site [nucleotide binding]; DNA binding site
981540000485	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
981540000486	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
981540000487	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
981540000488	nucleotide binding site [chemical binding]; other site
981540000489	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834
981540000490	active site
981540000491	catalytic triad [active]
981540000492	oxyanion hole [active]
981540000493	Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448
981540000494	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
981540000495	HD domain; Region: HD_4; pfam13328
981540000496	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
981540000497	synthetase active site [active]
981540000498	NTP binding site [chemical binding]; other site
981540000499	metal binding site [ion binding]; metal-binding site
981540000500	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
981540000501	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
981540000502	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
981540000503	putative active site [active]
981540000504	dimerization interface [polypeptide binding]; other site
981540000505	putative tRNAtyr binding site [nucleotide binding]; other site
981540000506	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
981540000507	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
981540000508	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
981540000509	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
981540000510	Walker A/P-loop; other site
981540000511	ATP binding site [chemical binding]; other site
981540000512	Q-loop/lid; other site
981540000513	ABC transporter signature motif; other site
981540000514	Walker B; other site
981540000515	D-loop; other site
981540000516	H-loop/switch region; other site
981540000517	TOBE domain; Region: TOBE_2; pfam08402
981540000518	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
981540000519	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
981540000520	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
981540000521	Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485
981540000522	galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622
981540000523	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
981540000524	tagatose-6-phosphate kinase; Region: lacC; TIGR01231
981540000525	putative substrate binding site [chemical binding]; other site
981540000526	putative ATP binding site [chemical binding]; other site
981540000527	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399
981540000528	Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: PtsN; COG1762
981540000529	active site
981540000530	phosphorylation site [posttranslational modification]
981540000531	Phosphotransferase system, galactitol-specific IIB component [Carbohydrate transport and metabolism]; Region: SgaB; COG3414
981540000532	active site
981540000533	P-loop; other site
981540000534	phosphorylation site [posttranslational modification]
981540000535	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
981540000536	PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611
981540000537	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
981540000538	active site
981540000539	catalytic residues [active]
981540000540	transcriptional antiterminator BglG; Provisional; Region: PRK09772
981540000541	CAT RNA binding domain; Region: CAT_RBD; smart01061
981540000542	PRD domain; Region: PRD; pfam00874
981540000543	PRD domain; Region: PRD; pfam00874
981540000544	6-phospho-beta-galactosidase; Provisional; Region: PRK13511
981540000545	beta-galactosidase; Region: BGL; TIGR03356
981540000546	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
981540000547	methionine cluster; other site
981540000548	active site
981540000549	phosphorylation site [posttranslational modification]
981540000550	metal binding site [ion binding]; metal-binding site
981540000551	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295
981540000552	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
981540000553	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
981540000554	active site
981540000555	P-loop; other site
981540000556	phosphorylation site [posttranslational modification]
981540000557	Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672
981540000558	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
981540000559	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
981540000560	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
981540000561	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
981540000562	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
981540000563	Melibiase; Region: Melibiase; pfam02065
981540000564	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
981540000565	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
981540000566	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
981540000567	dimer interface [polypeptide binding]; other site
981540000568	conserved gate region; other site
981540000569	putative PBP binding loops; other site
981540000570	ABC-ATPase subunit interface; other site
981540000571	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
981540000572	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
981540000573	dimer interface [polypeptide binding]; other site
981540000574	conserved gate region; other site
981540000575	putative PBP binding loops; other site
981540000576	ABC-ATPase subunit interface; other site
981540000577	sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852
981540000578	Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355
981540000579	active site
981540000580	homodimer interface [polypeptide binding]; other site
981540000581	catalytic site [active]
981540000582	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
981540000583	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
981540000584	Ca binding site [ion binding]; other site
981540000585	active site
981540000586	catalytic site [active]
981540000587	DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339
981540000588	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
981540000589	DNA binding site [nucleotide binding]
981540000590	Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544
981540000591	putative dimerization interface [polypeptide binding]; other site
981540000592	putative ligand binding site [chemical binding]; other site
981540000593	galactokinase; Provisional; Region: PRK05322
981540000594	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
981540000595	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
981540000596	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
981540000597	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270
981540000598	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
981540000599	Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744
981540000600	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
981540000601	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
981540000602	NAD binding site [chemical binding]; other site
981540000603	homodimer interface [polypeptide binding]; other site
981540000604	active site
981540000605	substrate binding site [chemical binding]; other site
981540000606	truncated GNAT family acetyltransferase
981540000607	truncated GNAT family acetyltransferase
981540000608	preprotein translocase subunit YajC; Validated; Region: yajC; PRK06531
981540000609	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
981540000610	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
981540000611	catalytic residue [active]
981540000612	putative FPP diphosphate  binding site; other site
981540000613	putative FPP binding hydrophobic cleft; other site
981540000614	dimer interface [polypeptide binding]; other site
981540000615	putative IPP diphosphate binding site; other site
981540000616	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
981540000617	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
981540000618	RIP metalloprotease RseP; Region: TIGR00054
981540000619	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
981540000620	active site
981540000621	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
981540000622	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
981540000623	protein binding site [polypeptide binding]; other site
981540000624	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
981540000625	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
981540000626	putative substrate binding region [chemical binding]; other site
981540000627	putative substrate binding region [chemical binding]; other site
981540000628	prolyl-tRNA synthetase; Provisional; Region: PRK09194
981540000629	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
981540000630	motif 1; other site
981540000631	dimer interface [polypeptide binding]; other site
981540000632	active site
981540000633	motif 2; other site
981540000634	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
981540000635	putative deacylase active site [active]
981540000636	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
981540000637	active site
981540000638	motif 3; other site
981540000639	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
981540000640	anticodon binding site; other site
981540000641	DNA polymerase III PolC; Validated; Region: polC; PRK00448
981540000642	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
981540000643	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
981540000644	generic binding surface II; other site
981540000645	generic binding surface I; other site
981540000646	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
981540000647	active site
981540000648	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
981540000649	active site
981540000650	catalytic site [active]
981540000651	substrate binding site [chemical binding]; other site
981540000652	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
981540000653	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
981540000654	MarR family; Region: MarR; pfam01047
981540000655	MarR family; Region: MarR_2; cl17246
981540000656	Predicted flavoprotein [General function prediction only]; Region: COG0431
981540000657	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
981540000658	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
981540000659	active site
981540000660	catalytic residues [active]
981540000661	metal binding site [ion binding]; metal-binding site
981540000662	DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402
981540000663	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
981540000664	ligand binding site [chemical binding]; other site
981540000665	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
981540000666	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
981540000667	Major Facilitator Superfamily; Region: MFS_1; pfam07690
981540000668	putative substrate translocation pore; other site
981540000669	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
981540000670	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
981540000671	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
981540000672	putative active site [active]
981540000673	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_3; cd07241
981540000674	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
981540000675	putative metal binding site [ion binding]; other site
981540000676	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
981540000677	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
981540000678	active site
981540000679	motif I; other site
981540000680	motif II; other site
981540000681	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
981540000682	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
981540000683	16S/18S rRNA binding site [nucleotide binding]; other site
981540000684	S13e-L30e interaction site [polypeptide binding]; other site
981540000685	25S rRNA binding site [nucleotide binding]; other site
981540000686	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
981540000687	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
981540000688	putative catalytic cysteine [active]
981540000689	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
981540000690	putative active site [active]
981540000691	metal binding site [ion binding]; metal-binding site
981540000692	Predicted membrane protein [Function unknown]; Region: COG2261
981540000693	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
981540000694	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
981540000695	RNase E interface [polypeptide binding]; other site
981540000696	trimer interface [polypeptide binding]; other site
981540000697	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
981540000698	RNase E interface [polypeptide binding]; other site
981540000699	trimer interface [polypeptide binding]; other site
981540000700	active site
981540000701	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
981540000702	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
981540000703	RNA binding site [nucleotide binding]; other site
981540000704	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
981540000705	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
981540000706	trimer interface [polypeptide binding]; other site
981540000707	active site
981540000708	substrate binding site [chemical binding]; other site
981540000709	CoA binding site [chemical binding]; other site
981540000710	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
981540000711	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
981540000712	active site
981540000713	HIGH motif; other site
981540000714	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
981540000715	KMSKS motif; other site
981540000716	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
981540000717	tRNA binding surface [nucleotide binding]; other site
981540000718	anticodon binding site; other site
981540000719	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
981540000720	active site
981540000721	metal binding site [ion binding]; metal-binding site
981540000722	dimerization interface [polypeptide binding]; other site
981540000723	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
981540000724	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
981540000725	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
981540000726	YacP-like NYN domain; Region: NYN_YacP; cl01491
981540000727	EDD domain protein, DegV family; Region: DegV; TIGR00762
981540000728	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
981540000729	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
981540000730	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
981540000731	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
981540000732	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
981540000733	23S rRNA interface [nucleotide binding]; other site
981540000734	L3 interface [polypeptide binding]; other site
981540000735	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
981540000736	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
981540000737	active site
981540000738	DNA binding site [nucleotide binding]
981540000739	Int/Topo IB signature motif; other site
981540000740	Helix-turn-helix domain; Region: HTH_17; pfam12728
981540000741	putative replication initiation protein; Region: PHA00330
981540000742	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
981540000743	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
981540000744	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
981540000745	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
981540000746	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
981540000747	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
981540000748	catalytic core [active]
981540000749	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
981540000750	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
981540000751	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
981540000752	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
981540000753	GrpE; Region: GrpE; pfam01025
981540000754	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
981540000755	dimer interface [polypeptide binding]; other site
981540000756	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
981540000757	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
981540000758	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
981540000759	nucleotide binding site [chemical binding]; other site
981540000760	NEF interaction site [polypeptide binding]; other site
981540000761	SBD interface [polypeptide binding]; other site
981540000762	chaperone protein DnaJ; Provisional; Region: PRK14276
981540000763	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
981540000764	HSP70 interaction site [polypeptide binding]; other site
981540000765	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
981540000766	substrate binding site [polypeptide binding]; other site
981540000767	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
981540000768	Zn binding sites [ion binding]; other site
981540000769	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
981540000770	substrate binding site [polypeptide binding]; other site
981540000771	dimer interface [polypeptide binding]; other site
981540000772	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
981540000773	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
981540000774	dimerization interface 3.5A [polypeptide binding]; other site
981540000775	active site
981540000776	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
981540000777	dimer interface [polypeptide binding]; other site
981540000778	substrate binding site [chemical binding]; other site
981540000779	ATP binding site [chemical binding]; other site
981540000780	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155
981540000781	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
981540000782	hypothetical protein; Provisional; Region: PRK13690
981540000783	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
981540000784	Mechanosensitive ion channel; Region: MS_channel; pfam00924
981540000785	trigger factor; Provisional; Region: tig; PRK01490
981540000786	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
981540000787	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
981540000788	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066
981540000789	CTP synthetase; Validated; Region: pyrG; PRK05380
981540000790	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
981540000791	Catalytic site [active]
981540000792	active site
981540000793	UTP binding site [chemical binding]; other site
981540000794	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
981540000795	active site
981540000796	putative oxyanion hole; other site
981540000797	catalytic triad [active]
981540000798	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
981540000799	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
981540000800	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
981540000801	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
981540000802	intersubunit interface [polypeptide binding]; other site
981540000803	active site
981540000804	zinc binding site [ion binding]; other site
981540000805	Na+ binding site [ion binding]; other site
981540000806	Transposase IS200 like; Region: Y1_Tnp; pfam01797
981540000807	Transcriptional regulators [Transcription]; Region: PurR; COG1609
981540000808	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
981540000809	DNA binding site [nucleotide binding]
981540000810	domain linker motif; other site
981540000811	Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542
981540000812	dimerization interface [polypeptide binding]; other site
981540000813	ligand binding site [chemical binding]; other site
981540000814	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
981540000815	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
981540000816	active site turn [active]
981540000817	phosphorylation site [posttranslational modification]
981540000818	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
981540000819	sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322
981540000820	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
981540000821	substrate binding [chemical binding]; other site
981540000822	active site
981540000823	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
981540000824	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
981540000825	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
981540000826	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
981540000827	DAK2 domain; Region: Dak2; pfam02734
981540000828	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
981540000829	6-phosphogluconate dehydratase; Region: edd; TIGR01196
981540000830	acetolactate synthase catalytic subunit; Reviewed; Region: PRK07282
981540000831	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
981540000832	PYR/PP interface [polypeptide binding]; other site
981540000833	dimer interface [polypeptide binding]; other site
981540000834	TPP binding site [chemical binding]; other site
981540000835	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
981540000836	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
981540000837	TPP-binding site [chemical binding]; other site
981540000838	dimer interface [polypeptide binding]; other site
981540000839	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
981540000840	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
981540000841	putative valine binding site [chemical binding]; other site
981540000842	dimer interface [polypeptide binding]; other site
981540000843	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
981540000844	ketol-acid reductoisomerase; Provisional; Region: PRK05479
981540000845	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
981540000846	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
981540000847	threonine dehydratase; Validated; Region: PRK08639
981540000848	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
981540000849	tetramer interface [polypeptide binding]; other site
981540000850	pyridoxal 5'-phosphate binding site [chemical binding]; other site
981540000851	catalytic residue [active]
981540000852	C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585
981540000853	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
981540000854	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_4; cd03407
981540000855	VanZ like family; Region: VanZ; pfam04892
981540000856	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
981540000857	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
981540000858	Walker A/P-loop; other site
981540000859	ATP binding site [chemical binding]; other site
981540000860	Q-loop/lid; other site
981540000861	ABC transporter signature motif; other site
981540000862	Walker B; other site
981540000863	D-loop; other site
981540000864	H-loop/switch region; other site
981540000865	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
981540000866	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
981540000867	substrate binding pocket [chemical binding]; other site
981540000868	membrane-bound complex binding site; other site
981540000869	hinge residues; other site
981540000870	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
981540000871	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
981540000872	dimer interface [polypeptide binding]; other site
981540000873	conserved gate region; other site
981540000874	putative PBP binding loops; other site
981540000875	ABC-ATPase subunit interface; other site
981540000876	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
981540000877	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
981540000878	adaptor protein; Provisional; Region: PRK02315
981540000879	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
981540000880	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
981540000881	putative catalytic motif [active]
981540000882	substrate binding site [chemical binding]; other site
981540000883	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
981540000884	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
981540000885	Walker A/P-loop; other site
981540000886	ATP binding site [chemical binding]; other site
981540000887	Q-loop/lid; other site
981540000888	ABC transporter signature motif; other site
981540000889	Walker B; other site
981540000890	D-loop; other site
981540000891	H-loop/switch region; other site
981540000892	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
981540000893	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
981540000894	FeS assembly protein SufD; Region: sufD; TIGR01981
981540000895	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
981540000896	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
981540000897	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
981540000898	catalytic residue [active]
981540000899	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
981540000900	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
981540000901	trimerization site [polypeptide binding]; other site
981540000902	active site
981540000903	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
981540000904	FeS assembly protein SufB; Region: sufB; TIGR01980
981540000905	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
981540000906	Beta-lactamase; Region: Beta-lactamase; cl17358
981540000907	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
981540000908	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
981540000909	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
981540000910	peptide binding site [polypeptide binding]; other site
981540000911	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
981540000912	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
981540000913	dimer interface [polypeptide binding]; other site
981540000914	conserved gate region; other site
981540000915	putative PBP binding loops; other site
981540000916	ABC-ATPase subunit interface; other site
981540000917	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
981540000918	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
981540000919	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
981540000920	dimer interface [polypeptide binding]; other site
981540000921	conserved gate region; other site
981540000922	putative PBP binding loops; other site
981540000923	ABC-ATPase subunit interface; other site
981540000924	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
981540000925	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
981540000926	Walker A/P-loop; other site
981540000927	ATP binding site [chemical binding]; other site
981540000928	Q-loop/lid; other site
981540000929	ABC transporter signature motif; other site
981540000930	Walker B; other site
981540000931	D-loop; other site
981540000932	H-loop/switch region; other site
981540000933	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
981540000934	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
981540000935	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
981540000936	Walker A/P-loop; other site
981540000937	ATP binding site [chemical binding]; other site
981540000938	Q-loop/lid; other site
981540000939	ABC transporter signature motif; other site
981540000940	Walker B; other site
981540000941	D-loop; other site
981540000942	H-loop/switch region; other site
981540000943	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
981540000944	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
981540000945	aspartate kinase; Reviewed; Region: PRK09034
981540000946	AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245
981540000947	putative catalytic residues [active]
981540000948	putative nucleotide binding site [chemical binding]; other site
981540000949	putative aspartate binding site [chemical binding]; other site
981540000950	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
981540000951	allosteric regulatory residue; other site
981540000952	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
981540000953	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
981540000954	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
981540000955	motif II; other site
981540000956	enoyl-CoA hydratase; Provisional; Region: PRK07260
981540000957	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
981540000958	substrate binding site [chemical binding]; other site
981540000959	oxyanion hole (OAH) forming residues; other site
981540000960	trimer interface [polypeptide binding]; other site
981540000961	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
981540000962	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
981540000963	putative Zn2+ binding site [ion binding]; other site
981540000964	putative DNA binding site [nucleotide binding]; other site
981540000965	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
981540000966	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
981540000967	dimer interface [polypeptide binding]; other site
981540000968	active site
981540000969	CoA binding pocket [chemical binding]; other site
981540000970	acyl carrier protein; Provisional; Region: acpP; PRK00982
981540000971	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
981540000972	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
981540000973	FMN binding site [chemical binding]; other site
981540000974	substrate binding site [chemical binding]; other site
981540000975	putative catalytic residue [active]
981540000976	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
981540000977	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
981540000978	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
981540000979	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
981540000980	NAD(P) binding site [chemical binding]; other site
981540000981	homotetramer interface [polypeptide binding]; other site
981540000982	homodimer interface [polypeptide binding]; other site
981540000983	active site
981540000984	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
981540000985	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
981540000986	dimer interface [polypeptide binding]; other site
981540000987	active site
981540000988	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
981540000989	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
981540000990	carboxyltransferase (CT) interaction site; other site
981540000991	biotinylation site [posttranslational modification]; other site
981540000992	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
981540000993	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
981540000994	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
981540000995	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
981540000996	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
981540000997	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
981540000998	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
981540000999	acetyl-CoA carboxylase subunit alpha; Provisional; Region: PRK12319
981540001000	seryl-tRNA synthetase; Provisional; Region: PRK05431
981540001001	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
981540001002	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
981540001003	dimer interface [polypeptide binding]; other site
981540001004	active site
981540001005	motif 1; other site
981540001006	motif 2; other site
981540001007	motif 3; other site
981540001008	Domain of unknown function (DUF956); Region: DUF956; pfam06115
981540001009	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
981540001010	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
981540001011	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
981540001012	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
981540001013	active pocket/dimerization site; other site
981540001014	active site
981540001015	phosphorylation site [posttranslational modification]
981540001016	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
981540001017	active site
981540001018	phosphorylation site [posttranslational modification]
981540001019	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
981540001020	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
981540001021	active site
981540001022	motif I; other site
981540001023	motif II; other site
981540001024	Protein of unknown function (DUF1361); Region: DUF1361; pfam07099
981540001025	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
981540001026	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
981540001027	putative acetyltransferase YhhY; Provisional; Region: PRK10140
981540001028	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
981540001029	Coenzyme A binding pocket [chemical binding]; other site
981540001030	Transcriptional regulator [Transcription]; Region: LytR; COG1316
981540001031	truncated 6-phospho-beta-glucosidase
981540001032	transposase
981540001033	transposase
981540001034	transposase
981540001035	Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099
981540001036	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
981540001037	HIT family signature motif; other site
981540001038	catalytic residue [active]
981540001039	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
981540001040	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
981540001041	Walker A/P-loop; other site
981540001042	ATP binding site [chemical binding]; other site
981540001043	Q-loop/lid; other site
981540001044	ABC transporter signature motif; other site
981540001045	Walker B; other site
981540001046	D-loop; other site
981540001047	H-loop/switch region; other site
981540001048	Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975
981540001049	Thiamine kinase and related kinases [Coenzyme transport and metabolism]; Region: ycfN; COG0510
981540001050	Phosphotransferase enzyme family; Region: APH; pfam01636
981540001051	substrate binding site [chemical binding]; other site
981540001052	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
981540001053	S-adenosylmethionine binding site [chemical binding]; other site
981540001054	ribosome maturation protein RimP; Reviewed; Region: PRK00092
981540001055	Sm and related proteins; Region: Sm_like; cl00259
981540001056	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
981540001057	putative oligomer interface [polypeptide binding]; other site
981540001058	putative RNA binding site [nucleotide binding]; other site
981540001059	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
981540001060	NusA N-terminal domain; Region: NusA_N; pfam08529
981540001061	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
981540001062	RNA binding site [nucleotide binding]; other site
981540001063	homodimer interface [polypeptide binding]; other site
981540001064	NusA-like KH domain; Region: KH_5; pfam13184
981540001065	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
981540001066	G-X-X-G motif; other site
981540001067	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
981540001068	putative RNA binding cleft [nucleotide binding]; other site
981540001069	hypothetical protein; Provisional; Region: PRK07283
981540001070	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
981540001071	translation initiation factor IF-2; Region: IF-2; TIGR00487
981540001072	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
981540001073	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
981540001074	G1 box; other site
981540001075	putative GEF interaction site [polypeptide binding]; other site
981540001076	GTP/Mg2+ binding site [chemical binding]; other site
981540001077	Switch I region; other site
981540001078	G2 box; other site
981540001079	G3 box; other site
981540001080	Switch II region; other site
981540001081	G4 box; other site
981540001082	G5 box; other site
981540001083	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
981540001084	Translation-initiation factor 2; Region: IF-2; pfam11987
981540001085	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
981540001086	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
981540001087	Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641
981540001088	Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042
981540001089	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
981540001090	Penicillinase repressor; Region: Pencillinase_R; pfam03965
981540001091	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
981540001092	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
981540001093	metal-binding site [ion binding]
981540001094	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
981540001095	Soluble P-type ATPase [General function prediction only]; Region: COG4087
981540001096	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
981540001097	metal-binding site [ion binding]
981540001098	Predicted membrane protein [Function unknown]; Region: COG2860
981540001099	UPF0126 domain; Region: UPF0126; pfam03458
981540001100	UPF0126 domain; Region: UPF0126; pfam03458
981540001101	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
981540001102	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
981540001103	active site
981540001104	motif I; other site
981540001105	motif II; other site
981540001106	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
981540001107	truncated conserved hypothetical protein
981540001108	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
981540001109	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
981540001110	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307
981540001111	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
981540001112	Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688
981540001113	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
981540001114	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
981540001115	DNA-binding site [nucleotide binding]; DNA binding site
981540001116	UTRA domain; Region: UTRA; pfam07702
981540001117	putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815
981540001118	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
981540001119	dimer interface [polypeptide binding]; other site
981540001120	active site
981540001121	AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010
981540001122	putative active site [active]
981540001123	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399
981540001124	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
981540001125	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
981540001126	DNA-binding site [nucleotide binding]; DNA binding site
981540001127	UTRA domain; Region: UTRA; pfam07702
981540001128	Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301
981540001129	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
981540001130	active site
981540001131	phosphorylation site [posttranslational modification]
981540001132	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
981540001133	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
981540001134	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
981540001135	active pocket/dimerization site; other site
981540001136	active site
981540001137	phosphorylation site [posttranslational modification]
981540001138	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
981540001139	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
981540001140	active site
981540001141	dimer interface [polypeptide binding]; other site
981540001142	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
981540001143	dimer interface [polypeptide binding]; other site
981540001144	motif 1; other site
981540001145	active site
981540001146	motif 2; other site
981540001147	motif 3; other site
981540001148	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
981540001149	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
981540001150	hypothetical protein; Provisional; Region: PRK02539
981540001151	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
981540001152	HTH domain; Region: HTH_11; pfam08279
981540001153	Mga helix-turn-helix domain; Region: Mga; pfam05043
981540001154	PRD domain; Region: PRD; pfam00874
981540001155	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
981540001156	active site
981540001157	P-loop; other site
981540001158	phosphorylation site [posttranslational modification]
981540001159	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
981540001160	active site
981540001161	phosphorylation site [posttranslational modification]
981540001162	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
981540001163	active site
981540001164	phosphorylation site [posttranslational modification]
981540001165	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
981540001166	active site
981540001167	P-loop; other site
981540001168	phosphorylation site [posttranslational modification]
981540001169	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
981540001170	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
981540001171	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
981540001172	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
981540001173	substrate binding site [chemical binding]; other site
981540001174	hexamer interface [polypeptide binding]; other site
981540001175	metal binding site [ion binding]; metal-binding site
981540001176	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
981540001177	active site
981540001178	intersubunit interactions; other site
981540001179	catalytic residue [active]
981540001180	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
981540001181	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
981540001182	TPP-binding site [chemical binding]; other site
981540001183	dimer interface [polypeptide binding]; other site
981540001184	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
981540001185	PYR/PP interface [polypeptide binding]; other site
981540001186	dimer interface [polypeptide binding]; other site
981540001187	TPP binding site [chemical binding]; other site
981540001188	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
981540001189	Enterocin A Immunity; Region: EntA_Immun; pfam08951
981540001190	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
981540001191	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
981540001192	Walker A/P-loop; other site
981540001193	ATP binding site [chemical binding]; other site
981540001194	Q-loop/lid; other site
981540001195	ABC transporter signature motif; other site
981540001196	Walker B; other site
981540001197	D-loop; other site
981540001198	H-loop/switch region; other site
981540001199	Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263
981540001200	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
981540001201	nucleotide binding site [chemical binding]; other site
981540001202	homotetrameric interface [polypeptide binding]; other site
981540001203	putative phosphate binding site [ion binding]; other site
981540001204	putative allosteric binding site; other site
981540001205	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
981540001206	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
981540001207	putative catalytic cysteine [active]
981540001208	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
981540001209	MraW methylase family; Region: Methyltransf_5; pfam01795
981540001210	Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839
981540001211	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
981540001212	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
981540001213	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
981540001214	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
981540001215	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
981540001216	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
981540001217	Mg++ binding site [ion binding]; other site
981540001218	putative catalytic motif [active]
981540001219	putative substrate binding site [chemical binding]; other site
981540001220	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
981540001221	DEAD-like helicases superfamily; Region: DEXDc; smart00487
981540001222	ATP binding site [chemical binding]; other site
981540001223	Mg++ binding site [ion binding]; other site
981540001224	motif III; other site
981540001225	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
981540001226	nucleotide binding region [chemical binding]; other site
981540001227	ATP-binding site [chemical binding]; other site
981540001228	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
981540001229	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
981540001230	substrate binding pocket [chemical binding]; other site
981540001231	membrane-bound complex binding site; other site
981540001232	hinge residues; other site
981540001233	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
981540001234	dimer interface [polypeptide binding]; other site
981540001235	conserved gate region; other site
981540001236	putative PBP binding loops; other site
981540001237	ABC-ATPase subunit interface; other site
981540001238	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
981540001239	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
981540001240	Walker A/P-loop; other site
981540001241	ATP binding site [chemical binding]; other site
981540001242	Q-loop/lid; other site
981540001243	ABC transporter signature motif; other site
981540001244	Walker B; other site
981540001245	D-loop; other site
981540001246	H-loop/switch region; other site
981540001247	Protein of unknown function (DUF4059); Region: DUF4059; pfam13268
981540001248	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
981540001249	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
981540001250	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
981540001251	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
981540001252	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
981540001253	active site
981540001254	truncated NAD+ synthase
981540001255	truncated NAD+ synthase
981540001256	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
981540001257	trimer interface [polypeptide binding]; other site
981540001258	active site
981540001259	G bulge; other site
981540001260	Transglycosylase; Region: Transgly; pfam00912
981540001261	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
981540001262	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
981540001263	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
981540001264	hypothetical protein; Provisional; Region: PRK13660
981540001265	cell division protein GpsB; Provisional; Region: PRK14127
981540001266	DivIVA domain; Region: DivI1A_domain; TIGR03544
981540001267	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
981540001268	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
981540001269	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
981540001270	acetoin reductase; Validated; Region: PRK08643
981540001271	meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366
981540001272	NAD binding site [chemical binding]; other site
981540001273	homotetramer interface [polypeptide binding]; other site
981540001274	homodimer interface [polypeptide binding]; other site
981540001275	active site
981540001276	substrate binding site [chemical binding]; other site
981540001277	S-ribosylhomocysteinase; Provisional; Region: PRK02260
981540001278	hypothetical protein; Provisional; Region: PRK00106
981540001279	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
981540001280	Zn2+ binding site [ion binding]; other site
981540001281	Mg2+ binding site [ion binding]; other site
981540001282	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
981540001283	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
981540001284	catalytic site [active]
981540001285	G-X2-G-X-G-K; other site
981540001286	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
981540001287	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
981540001288	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
981540001289	ATP binding site [chemical binding]; other site
981540001290	putative Mg++ binding site [ion binding]; other site
981540001291	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
981540001292	ATP-binding site [chemical binding]; other site
981540001293	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
981540001294	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
981540001295	putative active site [active]
981540001296	substrate binding site [chemical binding]; other site
981540001297	putative cosubstrate binding site; other site
981540001298	catalytic site [active]
981540001299	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
981540001300	substrate binding site [chemical binding]; other site
981540001301	16S rRNA methyltransferase B; Provisional; Region: PRK14902
981540001302	NusB family; Region: NusB; pfam01029
981540001303	putative RNA binding site [nucleotide binding]; other site
981540001304	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
981540001305	S-adenosylmethionine binding site [chemical binding]; other site
981540001306	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
981540001307	active site
981540001308	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
981540001309	Catalytic domain of Protein Kinases; Region: PKc; cd00180
981540001310	active site
981540001311	ATP binding site [chemical binding]; other site
981540001312	substrate binding site [chemical binding]; other site
981540001313	activation loop (A-loop); other site
981540001314	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
981540001315	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768
981540001316	PASTA domain; Region: PASTA; pfam03793
981540001317	Predicted membrane protein [Function unknown]; Region: COG4758
981540001318	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
981540001319	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
981540001320	Histidine kinase; Region: HisKA_3; pfam07730
981540001321	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
981540001322	ATP binding site [chemical binding]; other site
981540001323	Mg2+ binding site [ion binding]; other site
981540001324	G-X-G motif; other site
981540001325	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
981540001326	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
981540001327	active site
981540001328	phosphorylation site [posttranslational modification]
981540001329	intermolecular recognition site; other site
981540001330	dimerization interface [polypeptide binding]; other site
981540001331	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
981540001332	DNA binding residues [nucleotide binding]
981540001333	dimerization interface [polypeptide binding]; other site
981540001334	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
981540001335	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
981540001336	active site
981540001337	motif I; other site
981540001338	motif II; other site
981540001339	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
981540001340	active site
981540001341	motif I; other site
981540001342	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
981540001343	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
981540001344	active site
981540001345	Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098
981540001346	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164
981540001347	RNA binding site [nucleotide binding]; other site
981540001348	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
981540001349	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
981540001350	dimer interface [polypeptide binding]; other site
981540001351	pyridoxal 5'-phosphate binding site [chemical binding]; other site
981540001352	catalytic residue [active]
981540001353	Uncharacterized conserved protein [Function unknown]; Region: COG1739
981540001354	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
981540001355	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
981540001356	Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098
981540001357	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
981540001358	ATP binding site [chemical binding]; other site
981540001359	putative Mg++ binding site [ion binding]; other site
981540001360	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
981540001361	nucleotide binding region [chemical binding]; other site
981540001362	ATP-binding site [chemical binding]; other site
981540001363	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
981540001364	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
981540001365	active site
981540001366	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
981540001367	30S subunit binding site; other site
981540001368	Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124
981540001369	hypothetical protein; Provisional; Region: PRK13662
981540001370	recombination regulator RecX; Provisional; Region: recX; PRK14135
981540001371	TRAM domain; Region: TRAM; pfam01938
981540001372	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
981540001373	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
981540001374	S-adenosylmethionine binding site [chemical binding]; other site
981540001375	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
981540001376	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
981540001377	Coenzyme A binding pocket [chemical binding]; other site
981540001378	truncated nicotinamide mononucleotide transporter
981540001379	truncated nicotinamide mononucleotide transporter
981540001380	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
981540001381	Substrate-binding site [chemical binding]; other site
981540001382	Substrate specificity [chemical binding]; other site
981540001383	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
981540001384	Coenzyme A binding pocket [chemical binding]; other site
981540001385	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
981540001386	Domain of unknown function (DUF1912); Region: DUF1912; pfam08930
981540001387	hypothetical protein; Provisional; Region: PRK07758
981540001388	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
981540001389	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
981540001390	AAA domain; Region: AAA_18; pfam13238
981540001391	Sulphate Transporter and Anti-Sigma factor antagonist domain found in the C-terminal region of sulphate transporters as well as in bacterial and archaeal proteins involved in the regulation of sigma factors; Region: STAS; cl00604
981540001392	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
981540001393	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
981540001394	active site
981540001395	HIGH motif; other site
981540001396	nucleotide binding site [chemical binding]; other site
981540001397	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
981540001398	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
981540001399	active site
981540001400	KMSKS motif; other site
981540001401	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
981540001402	tRNA binding surface [nucleotide binding]; other site
981540001403	anticodon binding site; other site
981540001404	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
981540001405	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
981540001406	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
981540001407	cofactor binding site; other site
981540001408	DNA binding site [nucleotide binding]
981540001409	substrate interaction site [chemical binding]; other site
981540001410	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
981540001411	truncated histidine kinase
981540001412	truncated histidine kinase
981540001413	Integrase core domain; Region: rve; pfam00665
981540001414	Integrase core domain; Region: rve_3; pfam13683
981540001415	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
981540001416	Transposase; Region: DEDD_Tnp_IS110; pfam01548
981540001417	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
981540001418	Protein of unknown function (DUF419); Region: DUF419; cl15265
981540001419	truncated major facilitator superfamily protein
981540001420	truncated major facilitator superfamily protein
981540001421	truncated major facilitator superfamily protein
981540001422	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
981540001423	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
981540001424	Asparagine synthetase A [Amino acid transport and metabolism]; Region: AsnA; COG2502
981540001425	motif 1; other site
981540001426	dimer interface [polypeptide binding]; other site
981540001427	active site
981540001428	motif 2; other site
981540001429	motif 3; other site
981540001430	V-type ATP synthase subunit I; Validated; Region: PRK05771
981540001431	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
981540001432	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
981540001433	S-adenosylmethionine binding site [chemical binding]; other site
981540001434	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
981540001435	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
981540001436	active site
981540001437	(T/H)XGH motif; other site
981540001438	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
981540001439	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
981540001440	protein binding site [polypeptide binding]; other site
981540001441	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
981540001442	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
981540001443	active site
981540001444	metal binding site [ion binding]; metal-binding site
981540001445	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
981540001446	Protein of unknown function (DUF1027); Region: DUF1027; cl09961
981540001447	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455
981540001448	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
981540001449	FeS/SAM binding site; other site
981540001450	VanZ like family; Region: VanZ; pfam04892
981540001451	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
981540001452	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
981540001453	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
981540001454	Walker A/P-loop; other site
981540001455	ATP binding site [chemical binding]; other site
981540001456	Q-loop/lid; other site
981540001457	ABC transporter signature motif; other site
981540001458	Walker B; other site
981540001459	D-loop; other site
981540001460	H-loop/switch region; other site
981540001461	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
981540001462	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
981540001463	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
981540001464	Walker A/P-loop; other site
981540001465	ATP binding site [chemical binding]; other site
981540001466	Q-loop/lid; other site
981540001467	ABC transporter signature motif; other site
981540001468	Walker B; other site
981540001469	D-loop; other site
981540001470	H-loop/switch region; other site
981540001471	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
981540001472	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
981540001473	Walker A/P-loop; other site
981540001474	ATP binding site [chemical binding]; other site
981540001475	Q-loop/lid; other site
981540001476	ABC transporter signature motif; other site
981540001477	Walker B; other site
981540001478	D-loop; other site
981540001479	H-loop/switch region; other site
981540001480	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
981540001481	Histidine kinase; Region: HisKA_3; pfam07730
981540001482	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
981540001483	ATP binding site [chemical binding]; other site
981540001484	Mg2+ binding site [ion binding]; other site
981540001485	G-X-G motif; other site
981540001486	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
981540001487	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
981540001488	active site
981540001489	phosphorylation site [posttranslational modification]
981540001490	intermolecular recognition site; other site
981540001491	dimerization interface [polypeptide binding]; other site
981540001492	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
981540001493	DNA binding residues [nucleotide binding]
981540001494	dimerization interface [polypeptide binding]; other site
981540001495	truncated alcohol dehydrogenase
981540001496	truncated conjugative transposon protein
981540001497	Predicted transcriptional regulators [Transcription]; Region: COG1725
981540001498	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
981540001499	DNA-binding site [nucleotide binding]; DNA binding site
981540001500	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
981540001501	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
981540001502	Walker A/P-loop; other site
981540001503	ATP binding site [chemical binding]; other site
981540001504	Q-loop/lid; other site
981540001505	ABC transporter signature motif; other site
981540001506	Walker B; other site
981540001507	D-loop; other site
981540001508	H-loop/switch region; other site
981540001509	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
981540001510	truncated chorismate mutase
981540001511	truncated anthranilate synthase component I
981540001512	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
981540001513	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
981540001514	truncated XRE family transcriptional regulator
981540001515	truncated conjugative transposon protein
981540001516	manganese transport protein MntH; Reviewed; Region: PRK00701
981540001517	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
981540001518	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
981540001519	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
981540001520	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
981540001521	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
981540001522	dimerization interface [polypeptide binding]; other site
981540001523	DPS ferroxidase diiron center [ion binding]; other site
981540001524	ion pore; other site
981540001525	Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014
981540001526	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
981540001527	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
981540001528	nucleotide binding site [chemical binding]; other site
981540001529	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
981540001530	active site residue [active]
981540001531	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
981540001532	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
981540001533	G1 box; other site
981540001534	putative GEF interaction site [polypeptide binding]; other site
981540001535	GTP/Mg2+ binding site [chemical binding]; other site
981540001536	Switch I region; other site
981540001537	G2 box; other site
981540001538	G3 box; other site
981540001539	Switch II region; other site
981540001540	G4 box; other site
981540001541	G5 box; other site
981540001542	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
981540001543	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
981540001544	Protein of unknown function (DUF3165); Region: DUF3165; pfam11364
981540001545	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
981540001546	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
981540001547	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
981540001548	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
981540001549	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
981540001550	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
981540001551	homodimer interface [polypeptide binding]; other site
981540001552	active site
981540001553	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
981540001554	Cell division protein FtsQ; Region: FtsQ; pfam03799
981540001555	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
981540001556	Cell division protein FtsA; Region: FtsA; smart00842
981540001557	Cell division protein FtsA; Region: FtsA; pfam14450
981540001558	Domain of unknown function (DUF3484); Region: DUF3484; pfam11983
981540001559	cell division protein FtsZ; Validated; Region: PRK09330
981540001560	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
981540001561	nucleotide binding site [chemical binding]; other site
981540001562	SulA interaction site; other site
981540001563	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
981540001564	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
981540001565	catalytic residue [active]
981540001566	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
981540001567	YGGT family; Region: YGGT; pfam02325
981540001568	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
981540001569	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
981540001570	RNA binding surface [nucleotide binding]; other site
981540001571	DivIVA protein; Region: DivIVA; pfam05103
981540001572	DivIVA domain; Region: DivI1A_domain; TIGR03544
981540001573	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
981540001574	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
981540001575	active site
981540001576	HIGH motif; other site
981540001577	nucleotide binding site [chemical binding]; other site
981540001578	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
981540001579	active site
981540001580	KMSKS motif; other site
981540001581	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
981540001582	tRNA binding surface [nucleotide binding]; other site
981540001583	anticodon binding site; other site
981540001584	Domain of unknown function (DUF1827); Region: DUF1827; pfam08860
981540001585	Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684
981540001586	nudix motif; other site
981540001587	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
981540001588	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
981540001589	Walker A motif; other site
981540001590	ATP binding site [chemical binding]; other site
981540001591	Walker B motif; other site
981540001592	arginine finger; other site
981540001593	UvrB/uvrC motif; Region: UVR; pfam02151
981540001594	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
981540001595	Walker A motif; other site
981540001596	ATP binding site [chemical binding]; other site
981540001597	Walker B motif; other site
981540001598	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
981540001599	Protein of unknown function (DUF3278); Region: DUF3278; pfam11683
981540001600	ornithine carbamoyltransferase; Validated; Region: PRK02102
981540001601	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
981540001602	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
981540001603	Protein of unknown function (DUF1797); Region: DUF1797; cl11550
981540001604	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
981540001605	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
981540001606	dimer interface [polypeptide binding]; other site
981540001607	conserved gate region; other site
981540001608	putative PBP binding loops; other site
981540001609	ABC-ATPase subunit interface; other site
981540001610	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
981540001611	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
981540001612	Walker A/P-loop; other site
981540001613	ATP binding site [chemical binding]; other site
981540001614	Q-loop/lid; other site
981540001615	ABC transporter signature motif; other site
981540001616	Walker B; other site
981540001617	D-loop; other site
981540001618	H-loop/switch region; other site
981540001619	This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899
981540001620	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
981540001621	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
981540001622	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
981540001623	G1 box; other site
981540001624	GTP/Mg2+ binding site [chemical binding]; other site
981540001625	Switch I region; other site
981540001626	G2 box; other site
981540001627	G3 box; other site
981540001628	Switch II region; other site
981540001629	G4 box; other site
981540001630	G5 box; other site
981540001631	Nucleoside recognition; Region: Gate; pfam07670
981540001632	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
981540001633	Nucleoside recognition; Region: Gate; pfam07670
981540001634	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179
981540001635	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
981540001636	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
981540001637	homodimer interface [polypeptide binding]; other site
981540001638	NADP binding site [chemical binding]; other site
981540001639	substrate binding site [chemical binding]; other site
981540001640	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
981540001641	putative substrate binding site [chemical binding]; other site
981540001642	putative ATP binding site [chemical binding]; other site
981540001643	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
981540001644	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
981540001645	generic binding surface II; other site
981540001646	generic binding surface I; other site
981540001647	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
981540001648	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
981540001649	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
981540001650	substrate binding pocket [chemical binding]; other site
981540001651	chain length determination region; other site
981540001652	substrate-Mg2+ binding site; other site
981540001653	catalytic residues [active]
981540001654	aspartate-rich region 1; other site
981540001655	active site lid residues [active]
981540001656	aspartate-rich region 2; other site
981540001657	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
981540001658	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
981540001659	RNA binding surface [nucleotide binding]; other site
981540001660	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
981540001661	Arginine repressor [Transcription]; Region: ArgR; COG1438
981540001662	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
981540001663	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
981540001664	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
981540001665	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
981540001666	Walker A/P-loop; other site
981540001667	ATP binding site [chemical binding]; other site
981540001668	Q-loop/lid; other site
981540001669	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
981540001670	ABC transporter signature motif; other site
981540001671	Walker B; other site
981540001672	D-loop; other site
981540001673	H-loop/switch region; other site
981540001674	EDD domain protein, DegV family; Region: DegV; TIGR00762
981540001675	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
981540001676	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506
981540001677	active site
981540001678	catalytic triad [active]
981540001679	oxyanion hole [active]
981540001680	Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911
981540001681	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
981540001682	IHF dimer interface [polypeptide binding]; other site
981540001683	IHF - DNA interface [nucleotide binding]; other site
981540001684	amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924
981540001685	POT family; Region: PTR2; pfam00854
981540001686	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
981540001687	Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741
981540001688	active site
981540001689	FMN binding site [chemical binding]; other site
981540001690	substrate binding site [chemical binding]; other site
981540001691	catalytic residues [active]
981540001692	homodimer interface [polypeptide binding]; other site
981540001693	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
981540001694	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR5; cd08271
981540001695	putative NAD(P) binding site [chemical binding]; other site
981540001696	substrate binding site [chemical binding]; other site
981540001697	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
981540001698	dimerization interface [polypeptide binding]; other site
981540001699	putative DNA binding site [nucleotide binding]; other site
981540001700	putative Zn2+ binding site [ion binding]; other site
981540001701	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
981540001702	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
981540001703	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
981540001704	motif I; other site
981540001705	motif II; other site
981540001706	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
981540001707	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
981540001708	catalytic core [active]
981540001709	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
981540001710	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
981540001711	Int/Topo IB signature motif; other site
981540001712	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
981540001713	non-specific DNA binding site [nucleotide binding]; other site
981540001714	salt bridge; other site
981540001715	sequence-specific DNA binding site [nucleotide binding]; other site
981540001716	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
981540001717	truncated predicted membrane protein
981540001718	truncated predicted membrane protein
981540001719	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
981540001720	HTH domain; Region: HTH_11; pfam08279
981540001721	3H domain; Region: 3H; pfam02829
981540001722	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
981540001723	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
981540001724	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
981540001725	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
981540001726	recombination protein RecR; Reviewed; Region: recR; PRK00076
981540001727	RecR protein; Region: RecR; pfam02132
981540001728	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
981540001729	putative active site [active]
981540001730	putative metal-binding site [ion binding]; other site
981540001731	tetramer interface [polypeptide binding]; other site
981540001732	Transcriptional regulators [Transcription]; Region: MarR; COG1846
981540001733	MarR family; Region: MarR_2; pfam12802
981540001734	Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775
981540001735	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
981540001736	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
981540001737	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
981540001738	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
981540001739	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; cl17272
981540001740	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
981540001741	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
981540001742	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
981540001743	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
981540001744	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
981540001745	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
981540001746	G1 box; other site
981540001747	putative GEF interaction site [polypeptide binding]; other site
981540001748	GTP/Mg2+ binding site [chemical binding]; other site
981540001749	Switch I region; other site
981540001750	G2 box; other site
981540001751	G3 box; other site
981540001752	Switch II region; other site
981540001753	G4 box; other site
981540001754	G5 box; other site
981540001755	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
981540001756	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
981540001757	DEAD-like helicases superfamily; Region: DEXDc; smart00487
981540001758	ATP binding site [chemical binding]; other site
981540001759	Mg++ binding site [ion binding]; other site
981540001760	motif III; other site
981540001761	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
981540001762	nucleotide binding region [chemical binding]; other site
981540001763	ATP-binding site [chemical binding]; other site
981540001764	truncated esterase/lipase
981540001765	truncated esterase/lipase
981540001766	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
981540001767	putative substrate translocation pore; other site
981540001768	Major Facilitator Superfamily; Region: MFS_1; pfam07690
981540001769	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
981540001770	Helix-turn-helix domain; Region: HTH_18; pfam12833
981540001771	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
981540001772	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
981540001773	nucleotide binding site [chemical binding]; other site
981540001774	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
981540001775	GIY-YIG motif/motif A; other site
981540001776	putative active site [active]
981540001777	putative metal binding site [ion binding]; other site
981540001778	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
981540001779	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
981540001780	S-adenosylmethionine binding site [chemical binding]; other site
981540001781	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
981540001782	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
981540001783	putative acyl-acceptor binding pocket; other site
981540001784	SLBB domain; Region: SLBB; pfam10531
981540001785	comEA protein; Region: comE; TIGR01259
981540001786	Helix-hairpin-helix motif; Region: HHH; pfam00633
981540001787	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
981540001788	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
981540001789	Competence protein; Region: Competence; pfam03772
981540001790	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
981540001791	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
981540001792	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
981540001793	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
981540001794	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
981540001795	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
981540001796	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
981540001797	hypothetical protein; Validated; Region: PRK00110
981540001798	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
981540001799	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
981540001800	CCC1-related family of proteins; Region: CCC1_like; cl00278
981540001801	VIT family; Region: VIT1; pfam01988
981540001802	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
981540001803	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
981540001804	active site
981540001805	trimer interface [polypeptide binding]; other site
981540001806	allosteric site; other site
981540001807	active site lid [active]
981540001808	hexamer (dimer of trimers) interface [polypeptide binding]; other site
981540001809	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
981540001810	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
981540001811	RNA binding surface [nucleotide binding]; other site
981540001812	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
981540001813	active site
981540001814	uracil binding [chemical binding]; other site
981540001815	Competence protein CoiA-like family; Region: CoiA; pfam06054
981540001816	Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164
981540001817	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
981540001818	active site
981540001819	Zn binding site [ion binding]; other site
981540001820	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
981540001821	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
981540001822	Coenzyme A binding pocket [chemical binding]; other site
981540001823	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
981540001824	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
981540001825	motif II; other site
981540001826	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
981540001827	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
981540001828	S-adenosylmethionine binding site [chemical binding]; other site
981540001829	foldase protein PrsA; Reviewed; Region: prsA; PRK01326
981540001830	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
981540001831	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
981540001832	motif 1; other site
981540001833	active site
981540001834	motif 2; other site
981540001835	motif 3; other site
981540001836	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
981540001837	DHHA1 domain; Region: DHHA1; pfam02272
981540001838	Predicted amidohydrolase [General function prediction only]; Region: COG0388
981540001839	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_5; cd07583
981540001840	putative active site [active]
981540001841	catalytic triad [active]
981540001842	putative dimer interface [polypeptide binding]; other site
981540001843	transaminase; Reviewed; Region: PRK08068
981540001844	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
981540001845	pyridoxal 5'-phosphate binding site [chemical binding]; other site
981540001846	homodimer interface [polypeptide binding]; other site
981540001847	catalytic residue [active]
981540001848	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
981540001849	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
981540001850	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
981540001851	heterotetramer interface [polypeptide binding]; other site
981540001852	active site pocket [active]
981540001853	cleavage site
981540001854	AAK_NAGK-like: N-Acetyl-L-glutamate kinase (NAGK)-like . Included in this CD are the Escherichia coli and Pseudomonas aeruginosa type NAGKs which catalyze the phosphorylation of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine...; Region: AAK_NAGK-like; cd04238
981540001855	nucleotide binding site [chemical binding]; other site
981540001856	N-acetyl-L-glutamate binding site [chemical binding]; other site
981540001857	acetylornithine aminotransferase; Provisional; Region: PRK04260
981540001858	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
981540001859	inhibitor-cofactor binding pocket; inhibition site
981540001860	pyridoxal 5'-phosphate binding site [chemical binding]; other site
981540001861	catalytic residue [active]
981540001862	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
981540001863	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
981540001864	non-specific DNA binding site [nucleotide binding]; other site
981540001865	salt bridge; other site
981540001866	sequence-specific DNA binding site [nucleotide binding]; other site
981540001867	Protein of unknown function (DUF3169); Region: DUF3169; pfam11368
981540001868	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
981540001869	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
981540001870	catalytic motif [active]
981540001871	Zn binding site [ion binding]; other site
981540001872	RibD C-terminal domain; Region: RibD_C; pfam01872
981540001873	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
981540001874	Lumazine binding domain; Region: Lum_binding; pfam00677
981540001875	Lumazine binding domain; Region: Lum_binding; pfam00677
981540001876	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
981540001877	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
981540001878	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
981540001879	dimerization interface [polypeptide binding]; other site
981540001880	active site
981540001881	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
981540001882	homopentamer interface [polypeptide binding]; other site
981540001883	active site
981540001884	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
981540001885	aminoethylphosphonate catabolism associated LysR family transcriptional regulator; Region: phn_lysR; TIGR03339
981540001886	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
981540001887	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
981540001888	active site
981540001889	catalytic tetrad [active]
981540001890	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
981540001891	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
981540001892	active site
981540001893	catalytic tetrad [active]
981540001894	truncated CorA-like Mg2+ transporter protein
981540001895	truncated CorA-like Mg2+ transporter protein
981540001896	truncated predicted membrane protein
981540001897	Thiamine transporter protein (Thia_YuaJ); Region: Thia_YuaJ; pfam09515
981540001898	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
981540001899	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
981540001900	dimer interface [polypeptide binding]; other site
981540001901	putative radical transfer pathway; other site
981540001902	diiron center [ion binding]; other site
981540001903	tyrosyl radical; other site
981540001904	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306
981540001905	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
981540001906	Class I ribonucleotide reductase; Region: RNR_I; cd01679
981540001907	active site
981540001908	dimer interface [polypeptide binding]; other site
981540001909	catalytic residues [active]
981540001910	effector binding site; other site
981540001911	R2 peptide binding site; other site
981540001912	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
981540001913	catalytic residues [active]
981540001914	aconitate hydratase; Validated; Region: PRK09277
981540001915	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
981540001916	substrate binding site [chemical binding]; other site
981540001917	ligand binding site [chemical binding]; other site
981540001918	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
981540001919	substrate binding site [chemical binding]; other site
981540001920	Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110
981540001921	dimer interface [polypeptide binding]; other site
981540001922	Citrate synthase; Region: Citrate_synt; pfam00285
981540001923	active site
981540001924	citrylCoA binding site [chemical binding]; other site
981540001925	oxalacetate/citrate binding site [chemical binding]; other site
981540001926	coenzyme A binding site [chemical binding]; other site
981540001927	catalytic triad [active]
981540001928	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
981540001929	isocitrate dehydrogenase; Validated; Region: PRK07362
981540001930	Predicted membrane protein [Function unknown]; Region: COG4905
981540001931	Protein of unknown function (DUF1113); Region: DUF1113; pfam06541
981540001932	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
981540001933	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
981540001934	active site
981540001935	motif I; other site
981540001936	motif II; other site
981540001937	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
981540001938	Transcriptional regulators [Transcription]; Region: PurR; COG1609
981540001939	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
981540001940	DNA binding site [nucleotide binding]
981540001941	domain linker motif; other site
981540001942	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
981540001943	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
981540001944	putative active site [active]
981540001945	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
981540001946	homotrimer interaction site [polypeptide binding]; other site
981540001947	putative active site [active]
981540001948	truncated 2-hydroxyglutaryl-CoA dehydratase activator
981540001949	truncated 2-hydroxyglutaryl-CoA dehydratase activator
981540001950	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
981540001951	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
981540001952	Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
981540001953	truncated predicted membrane protein
981540001954	truncated predicted membrane protein
981540001955	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
981540001956	GAF domain; Region: GAF_3; pfam13492
981540001957	Domain of unknown function (DUF4350); Region: DUF4350; pfam14258
981540001958	Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG4878; cd10924
981540001959	NodB motif; other site
981540001960	putative active site [active]
981540001961	putative catalytic site [active]
981540001962	putative Zn binding site [ion binding]; other site
981540001963	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_3; cd03813
981540001964	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
981540001965	Predicted membrane protein [Function unknown]; Region: COG4267
981540001966	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
981540001967	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
981540001968	NAD binding site [chemical binding]; other site
981540001969	homodimer interface [polypeptide binding]; other site
981540001970	active site
981540001971	substrate binding site [chemical binding]; other site
981540001972	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
981540001973	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
981540001974	Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044
981540001975	dimer interface [polypeptide binding]; other site
981540001976	phosphate binding site [ion binding]; other site
981540001977	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
981540001978	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
981540001979	Peptidase family C69; Region: Peptidase_C69; pfam03577
981540001980	truncated MutR family transcriptional regulator
981540001981	truncated predicted membrane protein
981540001982	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
981540001983	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
981540001984	metal binding site [ion binding]; metal-binding site
981540001985	YodA lipocalin-like domain; Region: YodA; pfam09223
981540001986	truncated conserved hypothetical protein
981540001987	truncated predicted membrane protein
981540001988	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
981540001989	truncated transposase
981540001990	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
981540001991	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
981540001992	FtsX-like permease family; Region: FtsX; pfam02687
981540001993	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
981540001994	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
981540001995	Walker A/P-loop; other site
981540001996	ATP binding site [chemical binding]; other site
981540001997	Q-loop/lid; other site
981540001998	ABC transporter signature motif; other site
981540001999	Walker B; other site
981540002000	D-loop; other site
981540002001	H-loop/switch region; other site
981540002002	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
981540002003	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
981540002004	FtsX-like permease family; Region: FtsX; pfam02687
981540002005	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
981540002006	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
981540002007	active site
981540002008	phosphorylation site [posttranslational modification]
981540002009	intermolecular recognition site; other site
981540002010	dimerization interface [polypeptide binding]; other site
981540002011	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
981540002012	DNA binding site [nucleotide binding]
981540002013	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
981540002014	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
981540002015	dimerization interface [polypeptide binding]; other site
981540002016	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
981540002017	dimer interface [polypeptide binding]; other site
981540002018	phosphorylation site [posttranslational modification]
981540002019	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
981540002020	ATP binding site [chemical binding]; other site
981540002021	Mg2+ binding site [ion binding]; other site
981540002022	G-X-G motif; other site
981540002023	truncated transposase
981540002024	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
981540002025	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
981540002026	DHH family; Region: DHH; pfam01368
981540002027	DHHA1 domain; Region: DHHA1; pfam02272
981540002028	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
981540002029	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
981540002030	dimerization domain swap beta strand [polypeptide binding]; other site
981540002031	regulatory protein interface [polypeptide binding]; other site
981540002032	active site
981540002033	regulatory phosphorylation site [posttranslational modification]; other site
981540002034	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
981540002035	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
981540002036	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
981540002037	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
981540002038	NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082
981540002039	NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412
981540002040	tetrameric interface [polypeptide binding]; other site
981540002041	activator binding site; other site
981540002042	NADP binding site [chemical binding]; other site
981540002043	substrate binding site [chemical binding]; other site
981540002044	catalytic residues [active]
981540002045	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270
981540002046	active site
981540002047	metal-binding site [ion binding]
981540002048	active site
981540002049	nucleotide-binding site [chemical binding]; other site
981540002050	nucleotide-binding site [chemical binding]; other site
981540002051	LPXTG motif containing; truncated lactocepin
981540002052	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
981540002053	DEAD-like helicases superfamily; Region: DEXDc; smart00487
981540002054	ATP binding site [chemical binding]; other site
981540002055	putative Mg++ binding site [ion binding]; other site
981540002056	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
981540002057	nucleotide binding region [chemical binding]; other site
981540002058	ATP-binding site [chemical binding]; other site
981540002059	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
981540002060	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
981540002061	Sugar specificity; other site
981540002062	Pyrimidine base specificity; other site
981540002063	ATP-binding site [chemical binding]; other site
981540002064	2-isopropylmalate synthase; Validated; Region: PRK00915
981540002065	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
981540002066	active site
981540002067	catalytic residues [active]
981540002068	metal binding site [ion binding]; metal-binding site
981540002069	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
981540002070	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
981540002071	tartrate dehydrogenase; Region: TTC; TIGR02089
981540002072	Predicted membrane protein [Function unknown]; Region: COG3326
981540002073	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
981540002074	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
981540002075	substrate binding site [chemical binding]; other site
981540002076	ligand binding site [chemical binding]; other site
981540002077	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
981540002078	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
981540002079	substrate binding site [chemical binding]; other site
981540002080	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
981540002081	GAF domain; Region: GAF_2; pfam13185
981540002082	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
981540002083	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
981540002084	Walker A motif; other site
981540002085	ATP binding site [chemical binding]; other site
981540002086	Walker B motif; other site
981540002087	arginine finger; other site
981540002088	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
981540002089	Protein of unknown function (DUF3272); Region: DUF3272; pfam11676
981540002090	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
981540002091	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
981540002092	DNA-binding site [nucleotide binding]; DNA binding site
981540002093	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
981540002094	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
981540002095	S-adenosylmethionine synthetase; Validated; Region: PRK05250
981540002096	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
981540002097	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
981540002098	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
981540002099	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
981540002100	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
981540002101	hinge; other site
981540002102	active site
981540002103	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
981540002104	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
981540002105	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
981540002106	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
981540002107	DNA-binding site [nucleotide binding]; DNA binding site
981540002108	DRTGG domain; Region: DRTGG; pfam07085
981540002109	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
981540002110	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
981540002111	active site
981540002112	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
981540002113	Predicted membrane protein [Function unknown]; Region: COG2246
981540002114	GtrA-like protein; Region: GtrA; pfam04138
981540002115	Predicted membrane protein [Function unknown]; Region: COG4708
981540002116	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
981540002117	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
981540002118	nucleotide binding pocket [chemical binding]; other site
981540002119	K-X-D-G motif; other site
981540002120	catalytic site [active]
981540002121	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
981540002122	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
981540002123	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
981540002124	Dimer interface [polypeptide binding]; other site
981540002125	BRCT sequence motif; other site
981540002126	putative lipid kinase; Reviewed; Region: PRK13055
981540002127	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
981540002128	truncated glucose-1-phosphate adenylyltransferase
981540002129	F0F1 ATP synthase subunit C; Provisional; Region: PRK13467
981540002130	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
981540002131	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
981540002132	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
981540002133	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
981540002134	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
981540002135	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
981540002136	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
981540002137	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
981540002138	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
981540002139	beta subunit interaction interface [polypeptide binding]; other site
981540002140	Walker A motif; other site
981540002141	ATP binding site [chemical binding]; other site
981540002142	Walker B motif; other site
981540002143	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
981540002144	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
981540002145	core domain interface [polypeptide binding]; other site
981540002146	delta subunit interface [polypeptide binding]; other site
981540002147	epsilon subunit interface [polypeptide binding]; other site
981540002148	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
981540002149	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
981540002150	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
981540002151	alpha subunit interaction interface [polypeptide binding]; other site
981540002152	Walker A motif; other site
981540002153	ATP binding site [chemical binding]; other site
981540002154	Walker B motif; other site
981540002155	inhibitor binding site; inhibition site
981540002156	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
981540002157	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
981540002158	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
981540002159	gamma subunit interface [polypeptide binding]; other site
981540002160	epsilon subunit interface [polypeptide binding]; other site
981540002161	LBP interface [polypeptide binding]; other site
981540002162	Protein of unknown function (DUF1146); Region: DUF1146; cl11486
981540002163	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
981540002164	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
981540002165	hinge; other site
981540002166	active site
981540002167	DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772
981540002168	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
981540002169	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; pfam01223
981540002170	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
981540002171	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
981540002172	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
981540002173	dimer interface [polypeptide binding]; other site
981540002174	motif 1; other site
981540002175	active site
981540002176	motif 2; other site
981540002177	motif 3; other site
981540002178	truncated GNAT family acetyltransferase, truncated
981540002179	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
981540002180	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
981540002181	putative tRNA-binding site [nucleotide binding]; other site
981540002182	B3/4 domain; Region: B3_4; pfam03483
981540002183	tRNA synthetase B5 domain; Region: B5; smart00874
981540002184	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
981540002185	dimer interface [polypeptide binding]; other site
981540002186	motif 1; other site
981540002187	motif 3; other site
981540002188	motif 2; other site
981540002189	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
981540002190	ATP-dependent nuclease subunit B; Region: rexB_recomb; TIGR02774
981540002191	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
981540002192	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
981540002193	Part of AAA domain; Region: AAA_19; pfam13245
981540002194	Family description; Region: UvrD_C_2; pfam13538
981540002195	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
981540002196	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
981540002197	substrate binding site [chemical binding]; other site
981540002198	THF binding site; other site
981540002199	zinc-binding site [ion binding]; other site
981540002200	hypothetical protein; Provisional; Region: PRK07329
981540002201	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
981540002202	active site
981540002203	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
981540002204	Protein of unknown function (DUF3042); Region: DUF3042; pfam11240
981540002205	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
981540002206	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
981540002207	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
981540002208	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
981540002209	HflX GTPase family; Region: HflX; cd01878
981540002210	G1 box; other site
981540002211	GTP/Mg2+ binding site [chemical binding]; other site
981540002212	Switch I region; other site
981540002213	G2 box; other site
981540002214	G3 box; other site
981540002215	Switch II region; other site
981540002216	G4 box; other site
981540002217	G5 box; other site
981540002218	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
981540002219	ribonuclease Z; Region: RNase_Z; TIGR02651
981540002220	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
981540002221	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
981540002222	NAD(P) binding site [chemical binding]; other site
981540002223	active site
981540002224	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
981540002225	DHH family; Region: DHH; pfam01368
981540002226	DHHA1 domain; Region: DHHA1; pfam02272
981540002227	Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141
981540002228	malate dehydrogenase; Provisional; Region: PRK13529
981540002229	Malic enzyme, N-terminal domain; Region: malic; pfam00390
981540002230	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
981540002231	NAD(P) binding site [chemical binding]; other site
981540002232	Membrane transport protein; Region: Mem_trans; cl09117
981540002233	Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275
981540002234	Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins.  PVA has an N-terminal...; Region: Ntn_PVA; cd00542
981540002235	active site
981540002236	YSIRK-targeted surface antigen transcriptional regulator; Region: adjacent_YSIRK; TIGR04094
981540002237	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
981540002238	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
981540002239	Rib/alpha/Esp surface antigen repeat; Region: rib_alpha; TIGR02331
981540002240	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
981540002241	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
981540002242	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
981540002243	Walker A/P-loop; other site
981540002244	ATP binding site [chemical binding]; other site
981540002245	Q-loop/lid; other site
981540002246	ABC transporter signature motif; other site
981540002247	Walker B; other site
981540002248	D-loop; other site
981540002249	H-loop/switch region; other site
981540002250	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
981540002251	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
981540002252	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
981540002253	ABC-2 type transporter; Region: ABC2_membrane; cl17235
981540002254	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
981540002255	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
981540002256	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
981540002257	active site
981540002258	Homoserine O-succinyltransferase; Region: HTS; pfam04204
981540002259	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
981540002260	proposed active site lysine [active]
981540002261	conserved cys residue [active]
981540002262	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
981540002263	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
981540002264	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
981540002265	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
981540002266	minor groove reading motif; other site
981540002267	helix-hairpin-helix signature motif; other site
981540002268	substrate binding pocket [chemical binding]; other site
981540002269	active site
981540002270	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
981540002271	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
981540002272	Family of unknown function (DUF633); Region: DUF633; pfam04816
981540002273	Uncharacterized conserved protein [Function unknown]; Region: COG0327
981540002274	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
981540002275	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
981540002276	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
981540002277	substrate binding site; other site
981540002278	tetramer interface; other site
981540002279	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
981540002280	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
981540002281	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
981540002282	NAD binding site [chemical binding]; other site
981540002283	substrate binding site [chemical binding]; other site
981540002284	homodimer interface [polypeptide binding]; other site
981540002285	active site
981540002286	HD domain; Region: HD_4; pfam13328
981540002287	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
981540002288	putative active site [active]
981540002289	nucleotide binding site [chemical binding]; other site
981540002290	nudix motif; other site
981540002291	putative metal binding site [ion binding]; other site
981540002292	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
981540002293	Domain of unknown function DUF20; Region: UPF0118; pfam01594
981540002294	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
981540002295	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
981540002296	TPR motif; other site
981540002297	binding surface
981540002298	Tetratricopeptide repeat; Region: TPR_12; pfam13424
981540002299	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
981540002300	binding surface
981540002301	TPR motif; other site
981540002302	Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895
981540002303	potassium-transporting ATPase subunit A; Provisional; Region: PRK05482
981540002304	potassium-transporting ATPase subunit B; Provisional; Region: PRK01122
981540002305	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
981540002306	K+-transporting ATPase, c chain; Region: KdpC; cl00944
981540002307	Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205
981540002308	Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702
981540002309	USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987
981540002310	Ligand Binding Site [chemical binding]; other site
981540002311	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
981540002312	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
981540002313	dimer interface [polypeptide binding]; other site
981540002314	phosphorylation site [posttranslational modification]
981540002315	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
981540002316	ATP binding site [chemical binding]; other site
981540002317	Mg2+ binding site [ion binding]; other site
981540002318	G-X-G motif; other site
981540002319	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
981540002320	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
981540002321	active site
981540002322	phosphorylation site [posttranslational modification]
981540002323	intermolecular recognition site; other site
981540002324	dimerization interface [polypeptide binding]; other site
981540002325	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
981540002326	DNA binding site [nucleotide binding]
981540002327	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
981540002328	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
981540002329	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
981540002330	motif II; other site
981540002331	acetolactate synthase; Reviewed; Region: PRK08617
981540002332	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
981540002333	PYR/PP interface [polypeptide binding]; other site
981540002334	dimer interface [polypeptide binding]; other site
981540002335	TPP binding site [chemical binding]; other site
981540002336	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
981540002337	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
981540002338	TPP-binding site [chemical binding]; other site
981540002339	Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527
981540002340	truncated IS861, transposase
981540002341	truncated IS861, transposase
981540002342	truncated IS861, transposase
981540002343	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
981540002344	active site
981540002345	phosphorylation site [posttranslational modification]
981540002346	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
981540002347	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
981540002348	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
981540002349	active pocket/dimerization site; other site
981540002350	active site
981540002351	phosphorylation site [posttranslational modification]
981540002352	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
981540002353	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
981540002354	Ca binding site [ion binding]; other site
981540002355	active site
981540002356	catalytic site [active]
981540002357	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
981540002358	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
981540002359	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
981540002360	putative active site [active]
981540002361	amino acid transporter; Region: 2A0306; TIGR00909
981540002362	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
981540002363	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
981540002364	Domain of unknown function (DUF814); Region: DUF814; pfam05670
981540002365	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
981540002366	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
981540002367	zinc binding site [ion binding]; other site
981540002368	putative ligand binding site [chemical binding]; other site
981540002369	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
981540002370	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
981540002371	TM-ABC transporter signature motif; other site
981540002372	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
981540002373	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
981540002374	Walker A/P-loop; other site
981540002375	ATP binding site [chemical binding]; other site
981540002376	Q-loop/lid; other site
981540002377	ABC transporter signature motif; other site
981540002378	Walker B; other site
981540002379	D-loop; other site
981540002380	H-loop/switch region; other site
981540002381	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
981540002382	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
981540002383	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
981540002384	Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268
981540002385	active site
981540002386	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
981540002387	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
981540002388	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
981540002389	ABC transporter; Region: ABC_tran_2; pfam12848
981540002390	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
981540002391	Uncharacterized conserved protein (DUF2203); Region: DUF2203; cl02056
981540002392	MarR family; Region: MarR_2; cl17246
981540002393	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
981540002394	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
981540002395	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
981540002396	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
981540002397	Walker A/P-loop; other site
981540002398	ATP binding site [chemical binding]; other site
981540002399	Q-loop/lid; other site
981540002400	ABC transporter signature motif; other site
981540002401	Walker B; other site
981540002402	D-loop; other site
981540002403	H-loop/switch region; other site
981540002404	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
981540002405	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
981540002406	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
981540002407	Walker A/P-loop; other site
981540002408	ATP binding site [chemical binding]; other site
981540002409	Q-loop/lid; other site
981540002410	ABC transporter signature motif; other site
981540002411	Walker B; other site
981540002412	D-loop; other site
981540002413	H-loop/switch region; other site
981540002414	truncated IS861, transposase
981540002415	truncated IS861, transposase
981540002416	truncated ABC transport system permease protein
981540002417	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
981540002418	MarR family; Region: MarR_2; pfam12802
981540002419	MarR family; Region: MarR_2; cl17246
981540002420	2-keto-3-deoxygluconate permease; Region: KdgT; cl14653
981540002421	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
981540002422	Coenzyme A binding pocket [chemical binding]; other site
981540002423	Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253
981540002424	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
981540002425	NAD(P) binding site [chemical binding]; other site
981540002426	Amidohydrolase; Region: Amidohydro_2; pfam04909
981540002427	active site
981540002428	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
981540002429	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
981540002430	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
981540002431	putative active site [active]
981540002432	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
981540002433	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
981540002434	putative active site cavity [active]
981540002435	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
981540002436	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
981540002437	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
981540002438	active site turn [active]
981540002439	phosphorylation site [posttranslational modification]
981540002440	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
981540002441	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
981540002442	tetramer interface [polypeptide binding]; other site
981540002443	TPP-binding site [chemical binding]; other site
981540002444	heterodimer interface [polypeptide binding]; other site
981540002445	phosphorylation loop region [posttranslational modification]
981540002446	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
981540002447	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
981540002448	alpha subunit interface [polypeptide binding]; other site
981540002449	TPP binding site [chemical binding]; other site
981540002450	heterodimer interface [polypeptide binding]; other site
981540002451	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
981540002452	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
981540002453	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
981540002454	E3 interaction surface; other site
981540002455	lipoyl attachment site [posttranslational modification]; other site
981540002456	e3 binding domain; Region: E3_binding; pfam02817
981540002457	e3 binding domain; Region: E3_binding; pfam02817
981540002458	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
981540002459	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
981540002460	E3 interaction surface; other site
981540002461	lipoyl attachment site [posttranslational modification]; other site
981540002462	dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350
981540002463	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
981540002464	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
981540002465	truncated iron complex transport system permease protein
981540002466	truncated metallo-beta-lactamase superfamily protein
981540002467	truncated metallo-beta-lactamase superfamily protein
981540002468	truncated IS200-like transposase
981540002469	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
981540002470	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
981540002471	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
981540002472	Transcriptional regulator [Transcription]; Region: LysR; COG0583
981540002473	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
981540002474	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
981540002475	dimerization interface [polypeptide binding]; other site
981540002476	Protein of unknown function (DUF3737); Region: DUF3737; pfam12541
981540002477	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
981540002478	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
981540002479	pyridoxal 5'-phosphate binding site [chemical binding]; other site
981540002480	homodimer interface [polypeptide binding]; other site
981540002481	catalytic residue [active]
981540002482	Uncharacterized conserved protein [Function unknown]; Region: COG4925
981540002483	Predicted flavin-nucleotide-binding protein [General function prediction only]; Region: COG3467
981540002484	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
981540002485	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
981540002486	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
981540002487	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
981540002488	putative substrate translocation pore; other site
981540002489	truncated alpha/beta superfamily hydrolase
981540002490	truncated major facilitator superfamily protein
981540002491	truncated NADPH-dependent FMN reductase
981540002492	hypothetical protein; Provisional; Region: PRK04143
981540002493	ADP-ribose binding site [chemical binding]; other site
981540002494	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846
981540002495	putative homotetramer interface [polypeptide binding]; other site
981540002496	putative homodimer interface [polypeptide binding]; other site
981540002497	putative allosteric switch controlling residues; other site
981540002498	putative metal binding site [ion binding]; other site
981540002499	putative homodimer-homodimer interface [polypeptide binding]; other site
981540002500	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
981540002501	active site residue [active]
981540002502	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
981540002503	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
981540002504	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
981540002505	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
981540002506	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
981540002507	active site residue [active]
981540002508	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
981540002509	active site residue [active]
981540002510	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
981540002511	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
981540002512	Zn2+ binding site [ion binding]; other site
981540002513	Mg2+ binding site [ion binding]; other site
981540002514	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
981540002515	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
981540002516	Coenzyme A binding pocket [chemical binding]; other site
981540002517	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
981540002518	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
981540002519	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
981540002520	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
981540002521	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
981540002522	motif II; other site
981540002523	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
981540002524	Protein of unknown function (DUF2974); Region: DUF2974; pfam11187
981540002525	Transcriptional regulator [Transcription]; Region: LysR; COG0583
981540002526	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
981540002527	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
981540002528	dimerization interface [polypeptide binding]; other site
981540002529	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
981540002530	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
981540002531	short chain dehydrogenase; Provisional; Region: PRK06940
981540002532	classical (c) SDRs; Region: SDR_c; cd05233
981540002533	NAD(P) binding site [chemical binding]; other site
981540002534	active site
981540002535	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
981540002536	NADH(P)-binding; Region: NAD_binding_10; pfam13460
981540002537	NAD(P) binding site [chemical binding]; other site
981540002538	active site
981540002539	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
981540002540	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
981540002541	DNA binding residues [nucleotide binding]
981540002542	putative dimer interface [polypeptide binding]; other site
981540002543	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
981540002544	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
981540002545	active site
981540002546	catalytic tetrad [active]
981540002547	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
981540002548	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
981540002549	Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727
981540002550	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
981540002551	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
981540002552	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
981540002553	Walker A/P-loop; other site
981540002554	ATP binding site [chemical binding]; other site
981540002555	Q-loop/lid; other site
981540002556	ABC transporter signature motif; other site
981540002557	Walker B; other site
981540002558	D-loop; other site
981540002559	H-loop/switch region; other site
981540002560	Ion channel; Region: Ion_trans_2; pfam07885
981540002561	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
981540002562	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
981540002563	motif II; other site
981540002564	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
981540002565	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
981540002566	ligand binding site [chemical binding]; other site
981540002567	flexible hinge region; other site
981540002568	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
981540002569	non-specific DNA interactions [nucleotide binding]; other site
981540002570	DNA binding site [nucleotide binding]
981540002571	sequence specific DNA binding site [nucleotide binding]; other site
981540002572	putative cAMP binding site [chemical binding]; other site
981540002573	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
981540002574	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
981540002575	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
981540002576	putative dimerization interface [polypeptide binding]; other site
981540002577	Predicted membrane protein [Function unknown]; Region: COG2855
981540002578	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
981540002579	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
981540002580	NAD(P) binding site [chemical binding]; other site
981540002581	catalytic residues [active]
981540002582	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
981540002583	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
981540002584	GIY-YIG motif/motif A; other site
981540002585	active site
981540002586	catalytic site [active]
981540002587	putative DNA binding site [nucleotide binding]; other site
981540002588	metal binding site [ion binding]; metal-binding site
981540002589	UvrB/uvrC motif; Region: UVR; pfam02151
981540002590	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
981540002591	truncated hypothetical protein
981540002592	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
981540002593	dimer interface [polypeptide binding]; other site
981540002594	FMN binding site [chemical binding]; other site
981540002595	dipeptidase PepV; Reviewed; Region: PRK07318
981540002596	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
981540002597	active site
981540002598	metal binding site [ion binding]; metal-binding site
981540002599	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
981540002600	putative uracil binding site [chemical binding]; other site
981540002601	putative active site [active]
981540002602	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
981540002603	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
981540002604	trmE is a tRNA modification GTPase; Region: trmE; cd04164
981540002605	G1 box; other site
981540002606	GTP/Mg2+ binding site [chemical binding]; other site
981540002607	Switch I region; other site
981540002608	G2 box; other site
981540002609	Switch II region; other site
981540002610	G3 box; other site
981540002611	G4 box; other site
981540002612	G5 box; other site
981540002613	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
981540002614	Predicted membrane protein [Function unknown]; Region: COG2035
981540002615	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
981540002616	tetramer (dimer of dimers) interface [polypeptide binding]; other site
981540002617	active site
981540002618	dimer interface [polypeptide binding]; other site
981540002619	phosphopentomutase; Provisional; Region: PRK05362
981540002620	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
981540002621	purine nucleoside phosphorylase; Provisional; Region: PRK08202
981540002622	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
981540002623	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
981540002624	catalytic triad [active]
981540002625	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
981540002626	Putative ClC chloride channel.  Clc proteins are putative halogen ion (Cl-, Br- and I-) transporters found in eubacteria. They belong to the ClC superfamily of halogen ion channels, which share a unique double-barreled architecture and voltage-dependent...; Region: ClC_like; cd01033
981540002627	putative ion selectivity filter; other site
981540002628	putative pore gating glutamate residue; other site
981540002629	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
981540002630	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
981540002631	CRISPR/Cas system-associated protein Csm6; Region: Csm6_III-A; cl09873
981540002632	Transcriptional regulator [Transcription]; Region: LysR; COG0583
981540002633	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
981540002634	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
981540002635	dimerization interface [polypeptide binding]; other site
981540002636	DNA polymerase processivity factor; Region: DNA_PPF; pfam02916
981540002637	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; pfam03816
981540002638	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
981540002639	polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006
981540002640	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
981540002641	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
981540002642	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
981540002643	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
981540002644	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
981540002645	Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719
981540002646	NAD(P) binding site [chemical binding]; other site
981540002647	homodimer interface [polypeptide binding]; other site
981540002648	substrate binding site [chemical binding]; other site
981540002649	active site
981540002650	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
981540002651	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
981540002652	inhibitor-cofactor binding pocket; inhibition site
981540002653	pyridoxal 5'-phosphate binding site [chemical binding]; other site
981540002654	catalytic residue [active]
981540002655	Bacterial sugar transferase; Region: Bac_transf; pfam02397
981540002656	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
981540002657	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
981540002658	active site
981540002659	TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305
981540002660	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
981540002661	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
981540002662	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
981540002663	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
981540002664	active site
981540002665	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
981540002666	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
981540002667	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
981540002668	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
981540002669	non-specific DNA binding site [nucleotide binding]; other site
981540002670	salt bridge; other site
981540002671	sequence-specific DNA binding site [nucleotide binding]; other site
981540002672	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
981540002673	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
981540002674	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
981540002675	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
981540002676	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
981540002677	HTH domain; Region: HTH_11; pfam08279
981540002678	PRD domain; Region: PRD; pfam00874
981540002679	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
981540002680	active site
981540002681	P-loop; other site
981540002682	phosphorylation site [posttranslational modification]
981540002683	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
981540002684	active site
981540002685	phosphorylation site [posttranslational modification]
981540002686	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
981540002687	active site
981540002688	phosphorylation site [posttranslational modification]
981540002689	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
981540002690	active site
981540002691	P-loop; other site
981540002692	phosphorylation site [posttranslational modification]
981540002693	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
981540002694	alpha-mannosidase; Provisional; Region: PRK09819
981540002695	N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815
981540002696	active site
981540002697	metal binding site [ion binding]; metal-binding site
981540002698	catalytic site [active]
981540002699	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
981540002700	truncated IS861, transposase
981540002701	truncated IS861, transposase
981540002702	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
981540002703	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
981540002704	FAD binding pocket [chemical binding]; other site
981540002705	FAD binding motif [chemical binding]; other site
981540002706	phosphate binding motif [ion binding]; other site
981540002707	beta-alpha-beta structure motif; other site
981540002708	NAD binding pocket [chemical binding]; other site
981540002709	Iron coordination center [ion binding]; other site
981540002710	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
981540002711	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
981540002712	heterodimer interface [polypeptide binding]; other site
981540002713	active site
981540002714	FMN binding site [chemical binding]; other site
981540002715	homodimer interface [polypeptide binding]; other site
981540002716	substrate binding site [chemical binding]; other site
981540002717	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
981540002718	active site
981540002719	dimer interface [polypeptide binding]; other site
981540002720	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cl00217
981540002721	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
981540002722	active site
981540002723	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
981540002724	substrate binding site [chemical binding]; other site
981540002725	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
981540002726	ligand binding site [chemical binding]; other site
981540002727	active site
981540002728	UGI interface [polypeptide binding]; other site
981540002729	catalytic site [active]
981540002730	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
981540002731	conserved cys residue [active]
981540002732	dihydroorotase; Validated; Region: pyrC; PRK09357
981540002733	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
981540002734	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
981540002735	active site
981540002736	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
981540002737	DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058
981540002738	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
981540002739	Mg2+ binding site [ion binding]; other site
981540002740	G-X-G motif; other site
981540002741	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
981540002742	anchoring element; other site
981540002743	dimer interface [polypeptide binding]; other site
981540002744	ATP binding site [chemical binding]; other site
981540002745	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
981540002746	active site
981540002747	putative metal-binding site [ion binding]; other site
981540002748	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
981540002749	DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061
981540002750	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
981540002751	CAP-like domain; other site
981540002752	active site
981540002753	primary dimer interface [polypeptide binding]; other site
981540002754	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
981540002755	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
981540002756	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
981540002757	homodimer interface [polypeptide binding]; other site
981540002758	substrate-cofactor binding pocket; other site
981540002759	catalytic residue [active]
981540002760	Protein of unknown function (DUF2969); Region: DUF2969; pfam11184
981540002761	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
981540002762	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
981540002763	RNA binding site [nucleotide binding]; other site
981540002764	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
981540002765	RNA binding site [nucleotide binding]; other site
981540002766	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
981540002767	RNA binding site [nucleotide binding]; other site
981540002768	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
981540002769	RNA binding site [nucleotide binding]; other site
981540002770	LrgB-like family; Region: LrgB; pfam04172
981540002771	Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380
981540002772	Uncharacterized conserved protein [Function unknown]; Region: COG0398
981540002773	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
981540002774	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
981540002775	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
981540002776	Walker A/P-loop; other site
981540002777	ATP binding site [chemical binding]; other site
981540002778	Q-loop/lid; other site
981540002779	ABC transporter signature motif; other site
981540002780	Walker B; other site
981540002781	D-loop; other site
981540002782	H-loop/switch region; other site
981540002783	Predicted transcriptional regulators [Transcription]; Region: COG1725
981540002784	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
981540002785	DNA-binding site [nucleotide binding]; DNA binding site
981540002786	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279
981540002787	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
981540002788	active site
981540002789	PHP Thumb interface [polypeptide binding]; other site
981540002790	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
981540002791	generic binding surface II; other site
981540002792	generic binding surface I; other site
981540002793	6-phosphofructokinase; Provisional; Region: PRK03202
981540002794	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
981540002795	active site
981540002796	ADP/pyrophosphate binding site [chemical binding]; other site
981540002797	dimerization interface [polypeptide binding]; other site
981540002798	allosteric effector site; other site
981540002799	fructose-1,6-bisphosphate binding site; other site
981540002800	pyruvate kinase; Provisional; Region: PRK05826
981540002801	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
981540002802	domain interfaces; other site
981540002803	active site
981540002804	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
981540002805	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465
981540002806	Catalytic site [active]
981540002807	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
981540002808	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
981540002809	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
981540002810	glutaminase active site [active]
981540002811	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
981540002812	dimer interface [polypeptide binding]; other site
981540002813	active site
981540002814	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
981540002815	dimer interface [polypeptide binding]; other site
981540002816	active site
981540002817	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
981540002818	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
981540002819	PhnA protein; Region: PhnA; pfam03831
981540002820	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
981540002821	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
981540002822	dimer interface [polypeptide binding]; other site
981540002823	conserved gate region; other site
981540002824	ABC-ATPase subunit interface; other site
981540002825	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
981540002826	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
981540002827	Walker A/P-loop; other site
981540002828	ATP binding site [chemical binding]; other site
981540002829	Q-loop/lid; other site
981540002830	ABC transporter signature motif; other site
981540002831	Walker B; other site
981540002832	D-loop; other site
981540002833	H-loop/switch region; other site
981540002834	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
981540002835	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
981540002836	substrate binding pocket [chemical binding]; other site
981540002837	membrane-bound complex binding site; other site
981540002838	hinge residues; other site
981540002839	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
981540002840	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
981540002841	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994
981540002842	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
981540002843	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
981540002844	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
981540002845	beta-galactosidase; Region: BGL; TIGR03356
981540002846	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
981540002847	catalytic core [active]
981540002848	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
981540002849	catalytic core [active]
981540002850	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
981540002851	catalytic core [active]
981540002852	Domain of unknown function DUF20; Region: UPF0118; pfam01594
981540002853	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
981540002854	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
981540002855	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
981540002856	Ligand binding site; other site
981540002857	metal-binding site
981540002858	hypothetical protein; Reviewed; Region: PRK00024
981540002859	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
981540002860	MPN+ (JAMM) motif; other site
981540002861	Zinc-binding site [ion binding]; other site
981540002862	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
981540002863	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
981540002864	CoA binding domain; Region: CoA_binding; pfam02629
981540002865	Putative amino acid metabolism; Region: DUF1831; pfam08866
981540002866	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
981540002867	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
981540002868	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
981540002869	catalytic residue [active]
981540002870	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458
981540002871	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
981540002872	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
981540002873	active site
981540002874	Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762
981540002875	putative active site [active]
981540002876	putative metal binding residues [ion binding]; other site
981540002877	signature motif; other site
981540002878	putative triphosphate binding site [ion binding]; other site
981540002879	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
981540002880	synthetase active site [active]
981540002881	NTP binding site [chemical binding]; other site
981540002882	metal binding site [ion binding]; metal-binding site
981540002883	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
981540002884	ATP-NAD kinase; Region: NAD_kinase; pfam01513
981540002885	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
981540002886	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
981540002887	active site
981540002888	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
981540002889	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
981540002890	malonic semialdehyde reductase; Provisional; Region: PRK10538
981540002891	putative NAD(P) binding site [chemical binding]; other site
981540002892	homodimer interface [polypeptide binding]; other site
981540002893	homotetramer interface [polypeptide binding]; other site
981540002894	active site
981540002895	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
981540002896	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
981540002897	active site
981540002898	motif I; other site
981540002899	motif II; other site
981540002900	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
981540002901	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
981540002902	putative Zn2+ binding site [ion binding]; other site
981540002903	putative DNA binding site [nucleotide binding]; other site
981540002904	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
981540002905	Major Facilitator Superfamily; Region: MFS_1; pfam07690
981540002906	putative substrate translocation pore; other site
981540002907	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
981540002908	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
981540002909	beta-galactosidase; Region: BGL; TIGR03356
981540002910	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
981540002911	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
981540002912	Walker A/P-loop; other site
981540002913	ATP binding site [chemical binding]; other site
981540002914	Q-loop/lid; other site
981540002915	ABC transporter signature motif; other site
981540002916	Walker B; other site
981540002917	D-loop; other site
981540002918	H-loop/switch region; other site
981540002919	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
981540002920	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
981540002921	FtsX-like permease family; Region: FtsX; pfam02687
981540002922	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
981540002923	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
981540002924	active site
981540002925	truncated acyl carrier protein phosphodiesterase
981540002926	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
981540002927	active site
981540002928	xanthine permease; Region: pbuX; TIGR03173
981540002929	Sulfate transporter family; Region: Sulfate_transp; pfam00916
981540002930	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
981540002931	ApbE family; Region: ApbE; pfam02424
981540002932	4-oxalocrotonate tautomerase; Provisional; Region: PRK02289
981540002933	active site 1 [active]
981540002934	dimer interface [polypeptide binding]; other site
981540002935	hexamer interface [polypeptide binding]; other site
981540002936	active site 2 [active]
981540002937	thymidine kinase; Provisional; Region: PRK04296
981540002938	peptide chain release factor 1; Validated; Region: prfA; PRK00591
981540002939	This domain is found in peptide chain release factors; Region: PCRF; smart00937
981540002940	RF-1 domain; Region: RF-1; pfam00472
981540002941	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
981540002942	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
981540002943	S-adenosylmethionine binding site [chemical binding]; other site
981540002944	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
981540002945	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
981540002946	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
981540002947	dimer interface [polypeptide binding]; other site
981540002948	active site
981540002949	glycine-pyridoxal phosphate binding site [chemical binding]; other site
981540002950	folate binding site [chemical binding]; other site
981540002951	37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473
981540002952	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
981540002953	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
981540002954	N-acetyl-D-glucosamine binding site [chemical binding]; other site
981540002955	catalytic residue [active]
981540002956	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
981540002957	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
981540002958	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
981540002959	Walker A/P-loop; other site
981540002960	ATP binding site [chemical binding]; other site
981540002961	Q-loop/lid; other site
981540002962	ABC transporter signature motif; other site
981540002963	Walker B; other site
981540002964	D-loop; other site
981540002965	H-loop/switch region; other site
981540002966	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
981540002967	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
981540002968	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
981540002969	Walker A/P-loop; other site
981540002970	ATP binding site [chemical binding]; other site
981540002971	Q-loop/lid; other site
981540002972	ABC transporter signature motif; other site
981540002973	Walker B; other site
981540002974	D-loop; other site
981540002975	H-loop/switch region; other site
981540002976	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
981540002977	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
981540002978	active site
981540002979	Na/Ca binding site [ion binding]; other site
981540002980	catalytic site [active]
981540002981	Domain of unknown function (DUF1939); Region: DUF1939; pfam09154
981540002982	Uncharacterized conserved protein [Function unknown]; Region: COG0398
981540002983	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
981540002984	CAT RNA binding domain; Region: CAT_RBD; smart01061
981540002985	transcriptional antiterminator BglG; Provisional; Region: PRK09772
981540002986	PRD domain; Region: PRD; pfam00874
981540002987	PRD domain; Region: PRD; pfam00874
981540002988	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
981540002989	methionine cluster; other site
981540002990	active site
981540002991	phosphorylation site [posttranslational modification]
981540002992	metal binding site [ion binding]; metal-binding site
981540002993	phosphotransferase system, lactose specific, IIC component; Region: lac_pts_IIC; TIGR00394
981540002994	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
981540002995	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
981540002996	active site
981540002997	P-loop; other site
981540002998	phosphorylation site [posttranslational modification]
981540002999	6-phospho-beta-galactosidase; Provisional; Region: PRK13511
981540003000	beta-galactosidase; Region: BGL; TIGR03356
981540003001	GMP synthase; Reviewed; Region: guaA; PRK00074
981540003002	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
981540003003	AMP/PPi binding site [chemical binding]; other site
981540003004	candidate oxyanion hole; other site
981540003005	catalytic triad [active]
981540003006	potential glutamine specificity residues [chemical binding]; other site
981540003007	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
981540003008	ATP Binding subdomain [chemical binding]; other site
981540003009	Dimerization subdomain; other site
981540003010	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557
981540003011	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
981540003012	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
981540003013	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
981540003014	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
981540003015	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
981540003016	dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365
981540003017	phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484
981540003018	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
981540003019	amphipathic channel; other site
981540003020	Asn-Pro-Ala signature motifs; other site
981540003021	GIY-YIG domain of uncharacterized bacterial protein structurally related to COG3410; Region: GIY-YIG_COG3410; cd10439
981540003022	GIY-YIG motif/motif A; other site
981540003023	putative active site [active]
981540003024	putative metal binding site [ion binding]; other site
981540003025	AAA domain; Region: AAA_30; pfam13604
981540003026	Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848
981540003027	Uncharacterized conserved protein [Function unknown]; Region: COG3410
981540003028	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
981540003029	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
981540003030	DNA-binding site [nucleotide binding]; DNA binding site
981540003031	UTRA domain; Region: UTRA; pfam07702
981540003032	Predicted transcriptional regulator [Transcription]; Region: COG1959
981540003033	Transcriptional regulator; Region: Rrf2; pfam02082
981540003034	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
981540003035	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
981540003036	putative NAD(P) binding site [chemical binding]; other site
981540003037	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
981540003038	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
981540003039	signal recognition particle protein; Provisional; Region: PRK10867
981540003040	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
981540003041	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
981540003042	P loop; other site
981540003043	GTP binding site [chemical binding]; other site
981540003044	Signal peptide binding domain; Region: SRP_SPB; pfam02978
981540003045	site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084
981540003046	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
981540003047	active site
981540003048	DNA binding site [nucleotide binding]
981540003049	Int/Topo IB signature motif; other site
981540003050	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
981540003051	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
981540003052	non-specific DNA binding site [nucleotide binding]; other site
981540003053	salt bridge; other site
981540003054	sequence-specific DNA binding site [nucleotide binding]; other site
981540003055	Predicted transcriptional regulator [Transcription]; Region: COG2932
981540003056	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
981540003057	Catalytic site [active]
981540003058	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
981540003059	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
981540003060	ATP binding site [chemical binding]; other site
981540003061	Mg2+ binding site [ion binding]; other site
981540003062	G-X-G motif; other site
981540003063	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
981540003064	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
981540003065	active site
981540003066	phosphorylation site [posttranslational modification]
981540003067	intermolecular recognition site; other site
981540003068	dimerization interface [polypeptide binding]; other site
981540003069	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
981540003070	DNA binding site [nucleotide binding]
981540003071	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
981540003072	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
981540003073	Walker A/P-loop; other site
981540003074	ATP binding site [chemical binding]; other site
981540003075	Q-loop/lid; other site
981540003076	ABC transporter signature motif; other site
981540003077	Walker B; other site
981540003078	D-loop; other site
981540003079	H-loop/switch region; other site
981540003080	truncated conserved hypothetical protein
981540003081	truncated conserved hypothetical protein
981540003082	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
981540003083	Glucose inhibited division protein A; Region: GIDA; pfam01134
981540003084	truncated DNA topoisomerase I
981540003085	truncated DNA topoisomerase I
981540003086	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
981540003087	DNA protecting protein DprA; Region: dprA; TIGR00732
981540003088	maltose O-acetyltransferase; Provisional; Region: PRK10092
981540003089	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
981540003090	active site
981540003091	substrate binding site [chemical binding]; other site
981540003092	trimer interface [polypeptide binding]; other site
981540003093	CoA binding site [chemical binding]; other site
981540003094	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
981540003095	RNA/DNA hybrid binding site [nucleotide binding]; other site
981540003096	active site
981540003097	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
981540003098	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
981540003099	GTP/Mg2+ binding site [chemical binding]; other site
981540003100	G4 box; other site
981540003101	G5 box; other site
981540003102	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
981540003103	G1 box; other site
981540003104	G1 box; other site
981540003105	GTP/Mg2+ binding site [chemical binding]; other site
981540003106	Switch I region; other site
981540003107	G2 box; other site
981540003108	G2 box; other site
981540003109	G3 box; other site
981540003110	G3 box; other site
981540003111	Switch II region; other site
981540003112	Switch II region; other site
981540003113	G5 box; other site
981540003114	truncated Tn916 ORF7
981540003115	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
981540003116	FtsX-like permease family; Region: FtsX; pfam02687
981540003117	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
981540003118	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
981540003119	Walker A/P-loop; other site
981540003120	ATP binding site [chemical binding]; other site
981540003121	Q-loop/lid; other site
981540003122	ABC transporter signature motif; other site
981540003123	Walker B; other site
981540003124	D-loop; other site
981540003125	H-loop/switch region; other site
981540003126	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
981540003127	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
981540003128	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
981540003129	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
981540003130	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
981540003131	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
981540003132	motif II; other site
981540003133	D-mannonate oxidoreductase; Provisional; Region: PRK08277
981540003134	putative D-mannonate oxidoreductase, classical (c) SDR; Region: mannonate_red_SDR_c; cd08935
981540003135	putative NAD(P) binding site [chemical binding]; other site
981540003136	active site
981540003137	mannonate dehydratase; Provisional; Region: PRK03906
981540003138	mannonate dehydratase; Region: uxuA; TIGR00695
981540003139	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
981540003140	Glucuronate isomerase; Region: UxaC; pfam02614
981540003141	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
981540003142	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
981540003143	active site
981540003144	intersubunit interface [polypeptide binding]; other site
981540003145	catalytic residue [active]
981540003146	Transcriptional regulators [Transcription]; Region: FadR; COG2186
981540003147	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
981540003148	DNA-binding site [nucleotide binding]; DNA binding site
981540003149	FCD domain; Region: FCD; pfam07729
981540003150	beta-D-glucuronidase; Provisional; Region: PRK10150
981540003151	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
981540003152	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
981540003153	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
981540003154	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
981540003155	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
981540003156	substrate binding site [chemical binding]; other site
981540003157	ATP binding site [chemical binding]; other site
981540003158	MFS/sugar transport protein; Region: MFS_2; pfam13347
981540003159	melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392
981540003160	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
981540003161	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
981540003162	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
981540003163	ABC transporter; Region: ABC_tran_2; pfam12848
981540003164	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
981540003165	Predicted membrane protein [Function unknown]; Region: COG4720
981540003166	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
981540003167	dimer interface [polypeptide binding]; other site
981540003168	pyridoxal binding site [chemical binding]; other site
981540003169	ATP binding site [chemical binding]; other site
981540003170	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
981540003171	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
981540003172	DNA-binding site [nucleotide binding]; DNA binding site
981540003173	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
981540003174	pyridoxal 5'-phosphate binding site [chemical binding]; other site
981540003175	homodimer interface [polypeptide binding]; other site
981540003176	catalytic residue [active]
981540003177	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
981540003178	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
981540003179	dimer interface [polypeptide binding]; other site
981540003180	active site
981540003181	catalytic residue [active]
981540003182	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
981540003183	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
981540003184	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
981540003185	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
981540003186	Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154
981540003187	putative active site [active]
981540003188	catalytic site [active]
981540003189	Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160
981540003190	putative active site [active]
981540003191	catalytic site [active]
981540003192	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
981540003193	ABC-type multidrug transport system, ATPase component; Region: ABC_drug_resistance_like; cd03264
981540003194	Walker A/P-loop; other site
981540003195	ATP binding site [chemical binding]; other site
981540003196	Q-loop/lid; other site
981540003197	ABC transporter signature motif; other site
981540003198	Walker B; other site
981540003199	D-loop; other site
981540003200	H-loop/switch region; other site
981540003201	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
981540003202	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
981540003203	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
981540003204	DNA binding residues [nucleotide binding]
981540003205	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
981540003206	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
981540003207	Potassium binding sites [ion binding]; other site
981540003208	Cesium cation binding sites [ion binding]; other site
981540003209	truncated exopolysaccharide biosynthesis related protein
981540003210	phosphopantothenate--cysteine ligase; Validated; Region: PRK06732
981540003211	phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313
981540003212	Flavoprotein; Region: Flavoprotein; pfam02441
981540003213	Predicted membrane protein [Function unknown]; Region: COG4684
981540003214	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
981540003215	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
981540003216	active site
981540003217	substrate binding site [chemical binding]; other site
981540003218	metal binding site [ion binding]; metal-binding site
981540003219	truncated predicted membrane protein
981540003220	Predicted secreted protein [Function unknown]; Region: COG4086
981540003221	Protein of unknown function (DUF1002); Region: DUF1002; pfam06207
981540003222	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
981540003223	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
981540003224	putative metal binding site [ion binding]; other site
981540003225	Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165
981540003226	active site
981540003227	catalytic site [active]
981540003228	DNA gyrase subunit A; Validated; Region: PRK05560
981540003229	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
981540003230	CAP-like domain; other site
981540003231	active site
981540003232	primary dimer interface [polypeptide binding]; other site
981540003233	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
981540003234	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
981540003235	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
981540003236	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
981540003237	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
981540003238	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
981540003239	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
981540003240	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
981540003241	tetramer (dimer of dimers) interface [polypeptide binding]; other site
981540003242	NAD binding site [chemical binding]; other site
981540003243	dimer interface [polypeptide binding]; other site
981540003244	substrate binding site [chemical binding]; other site
981540003245	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
981540003246	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
981540003247	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
981540003248	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
981540003249	truncated IS1193 transposase
981540003250	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
981540003251	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
981540003252	TM-ABC transporter signature motif; other site
981540003253	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
981540003254	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
981540003255	TM-ABC transporter signature motif; other site
981540003256	truncated simple sugar transport system ATP-binding protein
981540003257	truncated simple sugar transport system ATP-binding protein
981540003258	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
981540003259	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
981540003260	ligand binding site [chemical binding]; other site
981540003261	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
981540003262	intersubunit interface [polypeptide binding]; other site
981540003263	active site
981540003264	catalytic residue [active]
981540003265	Methyltransferase domain; Region: Methyltransf_31; pfam13847
981540003266	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
981540003267	S-adenosylmethionine binding site [chemical binding]; other site
981540003268	pantothenate kinase; Provisional; Region: PRK05439
981540003269	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
981540003270	ATP-binding site [chemical binding]; other site
981540003271	CoA-binding site [chemical binding]; other site
981540003272	Mg2+-binding site [ion binding]; other site
981540003273	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
981540003274	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
981540003275	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
981540003276	dimer interface [polypeptide binding]; other site
981540003277	phosphorylation site [posttranslational modification]
981540003278	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
981540003279	ATP binding site [chemical binding]; other site
981540003280	Mg2+ binding site [ion binding]; other site
981540003281	G-X-G motif; other site
981540003282	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
981540003283	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
981540003284	active site
981540003285	phosphorylation site [posttranslational modification]
981540003286	intermolecular recognition site; other site
981540003287	dimerization interface [polypeptide binding]; other site
981540003288	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
981540003289	DNA binding site [nucleotide binding]
981540003290	Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601
981540003291	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
981540003292	Zn binding site [ion binding]; other site
981540003293	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
981540003294	PhoU domain; Region: PhoU; pfam01895
981540003295	PhoU domain; Region: PhoU; pfam01895
981540003296	phosphate transporter ATP-binding protein; Provisional; Region: PRK14239
981540003297	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
981540003298	Walker A/P-loop; other site
981540003299	ATP binding site [chemical binding]; other site
981540003300	Q-loop/lid; other site
981540003301	ABC transporter signature motif; other site
981540003302	Walker B; other site
981540003303	D-loop; other site
981540003304	H-loop/switch region; other site
981540003305	phosphate transporter ATP-binding protein; Provisional; Region: PRK14237
981540003306	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
981540003307	Walker A/P-loop; other site
981540003308	ATP binding site [chemical binding]; other site
981540003309	Q-loop/lid; other site
981540003310	ABC transporter signature motif; other site
981540003311	Walker B; other site
981540003312	D-loop; other site
981540003313	H-loop/switch region; other site
981540003314	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
981540003315	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
981540003316	dimer interface [polypeptide binding]; other site
981540003317	conserved gate region; other site
981540003318	putative PBP binding loops; other site
981540003319	ABC-ATPase subunit interface; other site
981540003320	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
981540003321	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
981540003322	dimer interface [polypeptide binding]; other site
981540003323	conserved gate region; other site
981540003324	putative PBP binding loops; other site
981540003325	ABC-ATPase subunit interface; other site
981540003326	phosphate binding protein; Region: ptsS_2; TIGR02136
981540003327	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
981540003328	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
981540003329	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
981540003330	S-adenosylmethionine binding site [chemical binding]; other site
981540003331	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
981540003332	truncated hypothetical protein
981540003333	glutathione reductase; Validated; Region: PRK06116
981540003334	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
981540003335	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
981540003336	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
981540003337	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
981540003338	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
981540003339	catalytic residues [active]
981540003340	Uncharacterized conserved protein [Function unknown]; Region: COG1359
981540003341	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
981540003342	ZIP Zinc transporter; Region: Zip; pfam02535
981540003343	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
981540003344	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
981540003345	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
981540003346	active site
981540003347	hypothetical protein; Provisional; Region: PRK04387
981540003348	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
981540003349	ArsC family; Region: ArsC; pfam03960
981540003350	putative catalytic residues [active]
981540003351	thiol/disulfide switch; other site
981540003352	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
981540003353	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
981540003354	active site
981540003355	Riboflavin kinase; Region: Flavokinase; pfam01687
981540003356	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484
981540003357	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
981540003358	RNA binding site [nucleotide binding]; other site
981540003359	active site
981540003360	tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
981540003361	Uncharacterized conserved protein [Function unknown]; Region: COG2461
981540003362	Family of unknown function (DUF438); Region: DUF438; pfam04282
981540003363	Domain of unknown function (DUF1858); Region: DUF1858; pfam08984
981540003364	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
981540003365	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
981540003366	Coenzyme A binding pocket [chemical binding]; other site
981540003367	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487
981540003368	Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903
981540003369	EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737
981540003370	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
981540003371	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
981540003372	Walker A/P-loop; other site
981540003373	ATP binding site [chemical binding]; other site
981540003374	Q-loop/lid; other site
981540003375	ABC transporter signature motif; other site
981540003376	Walker B; other site
981540003377	D-loop; other site
981540003378	H-loop/switch region; other site
981540003379	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
981540003380	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
981540003381	Walker A/P-loop; other site
981540003382	ATP binding site [chemical binding]; other site
981540003383	Q-loop/lid; other site
981540003384	ABC transporter signature motif; other site
981540003385	Walker B; other site
981540003386	D-loop; other site
981540003387	H-loop/switch region; other site
981540003388	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
981540003389	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605
981540003390	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
981540003391	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
981540003392	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
981540003393	Walker A/P-loop; other site
981540003394	ATP binding site [chemical binding]; other site
981540003395	Q-loop/lid; other site
981540003396	ABC transporter signature motif; other site
981540003397	Walker B; other site
981540003398	D-loop; other site
981540003399	H-loop/switch region; other site
981540003400	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
981540003401	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
981540003402	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
981540003403	Walker A/P-loop; other site
981540003404	ATP binding site [chemical binding]; other site
981540003405	Q-loop/lid; other site
981540003406	ABC transporter signature motif; other site
981540003407	Walker B; other site
981540003408	D-loop; other site
981540003409	H-loop/switch region; other site
981540003410	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
981540003411	FtsX-like permease family; Region: FtsX; pfam02687
981540003412	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
981540003413	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
981540003414	FtsX-like permease family; Region: FtsX; pfam02687
981540003415	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
981540003416	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
981540003417	Walker A/P-loop; other site
981540003418	ATP binding site [chemical binding]; other site
981540003419	Q-loop/lid; other site
981540003420	ABC transporter signature motif; other site
981540003421	Walker B; other site
981540003422	D-loop; other site
981540003423	H-loop/switch region; other site
981540003424	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
981540003425	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
981540003426	dimer interface [polypeptide binding]; other site
981540003427	catalytic triad [active]
981540003428	peroxidatic and resolving cysteines [active]
981540003429	truncated cyclase family protein
981540003430	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
981540003431	thiamine phosphate binding site [chemical binding]; other site
981540003432	active site
981540003433	pyrophosphate binding site [ion binding]; other site
981540003434	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
981540003435	substrate binding site [chemical binding]; other site
981540003436	multimerization interface [polypeptide binding]; other site
981540003437	ATP binding site [chemical binding]; other site
981540003438	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
981540003439	dimer interface [polypeptide binding]; other site
981540003440	substrate binding site [chemical binding]; other site
981540003441	ATP binding site [chemical binding]; other site
981540003442	TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243
981540003443	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
981540003444	?-D-glucose-1-phosphatase; Provisional; Region: PRK09456
981540003445	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
981540003446	S-adenosylmethionine binding site [chemical binding]; other site
981540003447	Thiamine-precursor transporter protein (ThiW); Region: ThiW; pfam09512
981540003448	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
981540003449	non-specific DNA binding site [nucleotide binding]; other site
981540003450	salt bridge; other site
981540003451	sequence-specific DNA binding site [nucleotide binding]; other site
981540003452	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
981540003453	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
981540003454	Part of AAA domain; Region: AAA_19; pfam13245
981540003455	Family description; Region: UvrD_C_2; pfam13538
981540003456	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
981540003457	amino acid carrier protein; Region: agcS; TIGR00835
981540003458	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
981540003459	Rrf2 family protein; Region: rrf2_super; TIGR00738
981540003460	Transcriptional regulator; Region: Rrf2; pfam02082
981540003461	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
981540003462	NAD(P) binding site [chemical binding]; other site
981540003463	active site
981540003464	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
981540003465	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
981540003466	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
981540003467	beta-galactosidase; Region: BGL; TIGR03356
981540003468	NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841
981540003469	active site
981540003470	catalytic triad [active]
981540003471	oxyanion hole [active]
981540003472	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
981540003473	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
981540003474	active site
981540003475	motif I; other site
981540003476	motif II; other site
981540003477	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
981540003478	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
981540003479	Ras GTPase Activating Domain; Region: RasGAP; cl02569
981540003480	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
981540003481	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
981540003482	beta-galactosidase; Region: BGL; TIGR03356
981540003483	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
981540003484	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
981540003485	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
981540003486	putative active site [active]
981540003487	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
981540003488	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
981540003489	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
981540003490	methionine cluster; other site
981540003491	active site
981540003492	phosphorylation site [posttranslational modification]
981540003493	metal binding site [ion binding]; metal-binding site
981540003494	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
981540003495	HTH domain; Region: HTH_11; pfam08279
981540003496	Mga helix-turn-helix domain; Region: Mga; pfam05043
981540003497	PRD domain; Region: PRD; pfam00874
981540003498	PRD domain; Region: PRD; pfam00874
981540003499	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
981540003500	active site
981540003501	P-loop; other site
981540003502	phosphorylation site [posttranslational modification]
981540003503	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
981540003504	active site
981540003505	phosphorylation site [posttranslational modification]
981540003506	cellobiose phosphotransferase system IIB component; Reviewed; Region: celB; PRK09590
981540003507	active site
981540003508	P-loop; other site
981540003509	phosphorylation site [posttranslational modification]
981540003510	Uncharacterized conserved protein [Function unknown]; Region: COG4095
981540003511	6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589
981540003512	beta-galactosidase; Region: BGL; TIGR03356
981540003513	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
981540003514	ABC1 family; Region: ABC1; cl17513
981540003515	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
981540003516	active site
981540003517	ATP binding site [chemical binding]; other site
981540003518	ABC1 family; Region: ABC1; cl17513
981540003519	Uncharacterized conserved protein [Function unknown]; Region: COG3937
981540003520	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
981540003521	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
981540003522	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
981540003523	Protein of unknown function (DUF1593); Region: DUF1593; pfam07632
981540003524	Carboxylesterase type B [Lipid metabolism]; Region: PnbA; COG2272
981540003525	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
981540003526	substrate binding pocket [chemical binding]; other site
981540003527	catalytic triad [active]
981540003528	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
981540003529	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
981540003530	active site turn [active]
981540003531	phosphorylation site [posttranslational modification]
981540003532	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
981540003533	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
981540003534	HPr interaction site; other site
981540003535	glycerol kinase (GK) interaction site [polypeptide binding]; other site
981540003536	active site
981540003537	phosphorylation site [posttranslational modification]
981540003538	transcriptional antiterminator BglG; Provisional; Region: PRK09772
981540003539	CAT RNA binding domain; Region: CAT_RBD; smart01061
981540003540	PRD domain; Region: PRD; pfam00874
981540003541	PRD domain; Region: PRD; pfam00874
981540003542	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
981540003543	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
981540003544	Cl- selectivity filter; other site
981540003545	Cl- binding residues [ion binding]; other site
981540003546	pore gating glutamate residue; other site
981540003547	dimer interface [polypeptide binding]; other site
981540003548	H+/Cl- coupling transport residue; other site
981540003549	TrkA-C domain; Region: TrkA_C; pfam02080
981540003550	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
981540003551	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
981540003552	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
981540003553	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
981540003554	dimer interface [polypeptide binding]; other site
981540003555	conserved gate region; other site
981540003556	putative PBP binding loops; other site
981540003557	ABC-ATPase subunit interface; other site
981540003558	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
981540003559	dimer interface [polypeptide binding]; other site
981540003560	conserved gate region; other site
981540003561	putative PBP binding loops; other site
981540003562	ABC-ATPase subunit interface; other site
981540003563	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
981540003564	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
981540003565	Walker A/P-loop; other site
981540003566	ATP binding site [chemical binding]; other site
981540003567	Q-loop/lid; other site
981540003568	ABC transporter signature motif; other site
981540003569	Walker B; other site
981540003570	D-loop; other site
981540003571	H-loop/switch region; other site
981540003572	TOBE domain; Region: TOBE_2; pfam08402
981540003573	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
981540003574	FAD binding domain; Region: FAD_binding_4; pfam01565
981540003575	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
981540003576	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
981540003577	catalytic center binding site [active]
981540003578	ATP binding site [chemical binding]; other site
981540003579	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
981540003580	homooctamer interface [polypeptide binding]; other site
981540003581	active site
981540003582	dihydropteroate synthase; Region: DHPS; TIGR01496
981540003583	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
981540003584	substrate binding pocket [chemical binding]; other site
981540003585	dimer interface [polypeptide binding]; other site
981540003586	inhibitor binding site; inhibition site
981540003587	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
981540003588	homodecamer interface [polypeptide binding]; other site
981540003589	GTP cyclohydrolase I; Provisional; Region: PLN03044
981540003590	active site
981540003591	putative catalytic site residues [active]
981540003592	zinc binding site [ion binding]; other site
981540003593	GTP-CH-I/GFRP interaction surface; other site
981540003594	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
981540003595	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
981540003596	truncated chorismate binding enzyme
981540003597	truncated chorismate binding enzyme
981540003598	truncated para-aminobenzoate synthetase / 4-amino-4-deoxychorismate lyase
981540003599	rarD protein; Region: rarD; TIGR00688
981540003600	EamA-like transporter family; Region: EamA; pfam00892
981540003601	homoserine kinase; Provisional; Region: PRK01212
981540003602	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
981540003603	homoserine dehydrogenase; Provisional; Region: PRK06349
981540003604	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
981540003605	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
981540003606	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
981540003607	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
981540003608	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
981540003609	putative active site [active]
981540003610	putative metal binding site [ion binding]; other site
981540003611	truncated TetR family transcriptional regulator
981540003612	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
981540003613	Int/Topo IB signature motif; other site
981540003614	Domain of unknown function (DUF3173); Region: DUF3173; pfam11372
981540003615	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
981540003616	Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147
981540003617	LanC is the cyclase enzyme of the lanthionine synthetase. Lanthinoine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as precursor peptides and then post-translationally modified to contain thioether cross-links...; Region: LanC; cd04793
981540003618	active site
981540003619	zinc binding site [ion binding]; other site
981540003620	truncated lantibiotic protection ABC transporter ATP-binding protein
981540003621	truncated lantibiotic protection ABC transporter ATP-binding protein
981540003622	Lantibiotic dehydratase, N terminus; Region: Lant_dehyd_N; pfam04737
981540003623	Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738
981540003624	SpaB C-terminal domain; Region: SpaB_C; pfam14028
981540003625	lantibiotic, gallidermin/nisin family; Region: lantibio_gallid; TIGR03731
981540003626	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
981540003627	lantibiotic protection ABC transporter permease subunit, MutE/EpiE family; Region: lanti_perm_MutE; TIGR03732
981540003628	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
981540003629	ATP-binding cassette domain of the bacitracin-resistance transporter; Region: ABC_BcrA_bacitracin_resist; cd03268
981540003630	Walker A/P-loop; other site
981540003631	ATP binding site [chemical binding]; other site
981540003632	Q-loop/lid; other site
981540003633	ABC transporter signature motif; other site
981540003634	Walker B; other site
981540003635	D-loop; other site
981540003636	H-loop/switch region; other site
981540003637	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
981540003638	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
981540003639	dimer interface [polypeptide binding]; other site
981540003640	phosphorylation site [posttranslational modification]
981540003641	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
981540003642	ATP binding site [chemical binding]; other site
981540003643	Mg2+ binding site [ion binding]; other site
981540003644	G-X-G motif; other site
981540003645	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
981540003646	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
981540003647	active site
981540003648	phosphorylation site [posttranslational modification]
981540003649	intermolecular recognition site; other site
981540003650	dimerization interface [polypeptide binding]; other site
981540003651	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
981540003652	DNA binding site [nucleotide binding]
981540003653	Peptidase S8 family domain in Lantiobiotic (lanthionine-containing antibiotics) specific proteases; Region: Peptidases_S8_Lantibiotic_specific_protease; cd07482
981540003654	active site
981540003655	catalytic triad [active]
981540003656	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
981540003657	Lantibiotic streptin immunity protein; Region: Streptin-Immun; pfam11083
981540003658	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
981540003659	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
981540003660	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
981540003661	Walker A motif; other site
981540003662	ATP binding site [chemical binding]; other site
981540003663	Walker B motif; other site
981540003664	arginine finger; other site
981540003665	Zeta toxin; Region: Zeta_toxin; pfam06414
981540003666	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185
981540003667	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
981540003668	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
981540003669	non-specific DNA binding site [nucleotide binding]; other site
981540003670	salt bridge; other site
981540003671	sequence-specific DNA binding site [nucleotide binding]; other site
981540003672	CHC2 zinc finger; Region: zf-CHC2; cl17510
981540003673	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
981540003674	Toprim-like; Region: Toprim_2; pfam13155
981540003675	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
981540003676	truncated SNF2/helicase family protein
981540003677	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
981540003678	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
981540003679	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
981540003680	putative active site [active]
981540003681	putative NTP binding site [chemical binding]; other site
981540003682	putative nucleic acid binding site [nucleotide binding]; other site
981540003683	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
981540003684	Methyltransferase domain; Region: Methyltransf_26; pfam13659
981540003685	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
981540003686	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
981540003687	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
981540003688	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
981540003689	helicase superfamily c-terminal domain; Region: HELICc; smart00490
981540003690	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
981540003691	Ca2+ binding site [ion binding]; other site
981540003692	Glucan-binding protein C; Region: GbpC; pfam08363
981540003693	adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228
981540003694	adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228
981540003695	adhesin isopeptide-forming domain, sspB-C2 type; Region: isopep_sspB_C2; TIGR04228
981540003696	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
981540003697	Transposase; Region: DEDD_Tnp_IS110; pfam01548
981540003698	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
981540003699	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
981540003700	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
981540003701	Peptidase family M23; Region: Peptidase_M23; pfam01551
981540003702	CHAP domain; Region: CHAP; pfam05257
981540003703	Domain of unknown function DUF87; Region: DUF87; pfam01935
981540003704	AAA-like domain; Region: AAA_10; pfam12846
981540003705	PrgI family protein; Region: PrgI; pfam12666
981540003706	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
981540003707	AAA-like domain; Region: AAA_10; pfam12846
981540003708	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
981540003709	Walker A motif; other site
981540003710	ATP binding site [chemical binding]; other site
981540003711	Walker B motif; other site
981540003712	CAAX protease self-immunity; Region: Abi; pfam02517
981540003713	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
981540003714	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
981540003715	cofactor binding site; other site
981540003716	DNA binding site [nucleotide binding]
981540003717	substrate interaction site [chemical binding]; other site
981540003718	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
981540003719	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
981540003720	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
981540003721	Int/Topo IB signature motif; other site
981540003722	Domain of unknown function (DUF3173); Region: DUF3173; pfam11372
981540003723	truncated plasmid replication protein
981540003724	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
981540003725	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
981540003726	truncated conserved hypothetical protein
981540003727	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
981540003728	non-specific DNA binding site [nucleotide binding]; other site
981540003729	salt bridge; other site
981540003730	sequence-specific DNA binding site [nucleotide binding]; other site
981540003731	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
981540003732	core dimer interface [polypeptide binding]; other site
981540003733	L10 interface [polypeptide binding]; other site
981540003734	L11 interface [polypeptide binding]; other site
981540003735	putative EF-Tu interaction site [polypeptide binding]; other site
981540003736	putative EF-G interaction site [polypeptide binding]; other site
981540003737	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
981540003738	23S rRNA interface [nucleotide binding]; other site
981540003739	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
981540003740	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
981540003741	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
981540003742	Walker A motif; other site
981540003743	ATP binding site [chemical binding]; other site
981540003744	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
981540003745	Walker B motif; other site
981540003746	arginine finger; other site
981540003747	UvrB/uvrC motif; Region: UVR; pfam02151
981540003748	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
981540003749	Walker A motif; other site
981540003750	ATP binding site [chemical binding]; other site
981540003751	Walker B motif; other site
981540003752	arginine finger; other site
981540003753	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
981540003754	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
981540003755	endonuclease III; Region: ENDO3c; smart00478
981540003756	minor groove reading motif; other site
981540003757	helix-hairpin-helix signature motif; other site
981540003758	substrate binding pocket [chemical binding]; other site
981540003759	active site
981540003760	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
981540003761	truncated conserved hypothetical protein
981540003762	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
981540003763	G1 box; other site
981540003764	GTP/Mg2+ binding site [chemical binding]; other site
981540003765	Switch I region; other site
981540003766	G2 box; other site
981540003767	G3 box; other site
981540003768	Switch II region; other site
981540003769	G4 box; other site
981540003770	G5 box; other site
981540003771	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
981540003772	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
981540003773	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
981540003774	Walker A motif; other site
981540003775	ATP binding site [chemical binding]; other site
981540003776	Walker B motif; other site
981540003777	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
981540003778	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
981540003779	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
981540003780	folate binding site [chemical binding]; other site
981540003781	NADP+ binding site [chemical binding]; other site
981540003782	thymidylate synthase; Reviewed; Region: thyA; PRK01827
981540003783	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
981540003784	dimerization interface [polypeptide binding]; other site
981540003785	active site
981540003786	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
981540003787	3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835
981540003788	dimer interface [polypeptide binding]; other site
981540003789	active site
981540003790	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
981540003791	homodimer interface [polypeptide binding]; other site
981540003792	catalytic residues [active]
981540003793	NAD binding site [chemical binding]; other site
981540003794	substrate binding pocket [chemical binding]; other site
981540003795	flexible flap; other site
981540003796	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
981540003797	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
981540003798	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
981540003799	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
981540003800	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
981540003801	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
981540003802	homotetramer interface [polypeptide binding]; other site
981540003803	FMN binding site [chemical binding]; other site
981540003804	homodimer contacts [polypeptide binding]; other site
981540003805	putative active site [active]
981540003806	putative substrate binding site [chemical binding]; other site
981540003807	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
981540003808	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
981540003809	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
981540003810	diphosphomevalonate decarboxylase; Region: PLN02407
981540003811	diphosphomevalonate decarboxylase; Region: mevDPdecarb; TIGR01240
981540003812	mevalonate kinase; Region: mevalon_kin; TIGR00549
981540003813	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
981540003814	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
981540003815	Walker A/P-loop; other site
981540003816	ATP binding site [chemical binding]; other site
981540003817	Q-loop/lid; other site
981540003818	ABC transporter signature motif; other site
981540003819	Walker B; other site
981540003820	D-loop; other site
981540003821	H-loop/switch region; other site
981540003822	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
981540003823	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
981540003824	dimer interface [polypeptide binding]; other site
981540003825	conserved gate region; other site
981540003826	putative PBP binding loops; other site
981540003827	ABC-ATPase subunit interface; other site
981540003828	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
981540003829	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
981540003830	dimer interface [polypeptide binding]; other site
981540003831	conserved gate region; other site
981540003832	putative PBP binding loops; other site
981540003833	ABC-ATPase subunit interface; other site
981540003834	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
981540003835	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
981540003836	substrate binding pocket [chemical binding]; other site
981540003837	membrane-bound complex binding site; other site
981540003838	hinge residues; other site
981540003839	The URO-D_CIMS_like protein superfamily includes bacterial and eukaryotic uroporphyrinogen decarboxylases (URO-D), coenzyme M methyltransferases and other putative bacterial methyltransferases, as well as cobalamine (B12) independent methionine synthases; Region: URO-D_CIMS_like; cl00464
981540003840	Transcriptional regulator [Transcription]; Region: LysR; COG0583
981540003841	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
981540003842	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
981540003843	dimerization interface [polypeptide binding]; other site
981540003844	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
981540003845	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
981540003846	active site
981540003847	catalytic tetrad [active]
981540003848	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
981540003849	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
981540003850	dimer interface [polypeptide binding]; other site
981540003851	phosphorylation site [posttranslational modification]
981540003852	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
981540003853	ATP binding site [chemical binding]; other site
981540003854	Mg2+ binding site [ion binding]; other site
981540003855	G-X-G motif; other site
981540003856	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
981540003857	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
981540003858	active site
981540003859	phosphorylation site [posttranslational modification]
981540003860	intermolecular recognition site; other site
981540003861	dimerization interface [polypeptide binding]; other site
981540003862	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; pfam00486
981540003863	DNA binding site [nucleotide binding]
981540003864	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
981540003865	synthetase active site [active]
981540003866	NTP binding site [chemical binding]; other site
981540003867	metal binding site [ion binding]; metal-binding site
981540003868	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
981540003869	dimer interface [polypeptide binding]; other site
981540003870	conserved gate region; other site
981540003871	ABC-ATPase subunit interface; other site
981540003872	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
981540003873	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
981540003874	Walker A/P-loop; other site
981540003875	ATP binding site [chemical binding]; other site
981540003876	Q-loop/lid; other site
981540003877	ABC transporter signature motif; other site
981540003878	Walker B; other site
981540003879	D-loop; other site
981540003880	H-loop/switch region; other site
981540003881	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
981540003882	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
981540003883	ABC-ATPase subunit interface; other site
981540003884	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
981540003885	MarR family; Region: MarR_2; pfam12802
981540003886	MarR family; Region: MarR_2; cl17246
981540003887	Quinone oxidoreductase (QOR); Region: quinone_oxidoreductase_like_1; cd08243
981540003888	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
981540003889	putative NAD(P) binding site [chemical binding]; other site
981540003890	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
981540003891	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
981540003892	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
981540003893	Walker A/P-loop; other site
981540003894	ATP binding site [chemical binding]; other site
981540003895	Q-loop/lid; other site
981540003896	ABC transporter signature motif; other site
981540003897	Walker B; other site
981540003898	D-loop; other site
981540003899	H-loop/switch region; other site
981540003900	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
981540003901	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
981540003902	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
981540003903	Walker A/P-loop; other site
981540003904	ATP binding site [chemical binding]; other site
981540003905	Q-loop/lid; other site
981540003906	ABC transporter signature motif; other site
981540003907	Walker B; other site
981540003908	D-loop; other site
981540003909	H-loop/switch region; other site
981540003910	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
981540003911	MarR family; Region: MarR_2; pfam12802
981540003912	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
981540003913	active site
981540003914	catalytic residues [active]
981540003915	metal binding site [ion binding]; metal-binding site
981540003916	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
981540003917	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
981540003918	Coenzyme A binding pocket [chemical binding]; other site
981540003919	glutamate dehydrogenase; Provisional; Region: PRK09414
981540003920	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
981540003921	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
981540003922	NAD(P) binding site [chemical binding]; other site
981540003923	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
981540003924	7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365
981540003925	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
981540003926	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
981540003927	active site
981540003928	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
981540003929	Ligand Binding Site [chemical binding]; other site
981540003930	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
981540003931	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
981540003932	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
981540003933	Walker A/P-loop; other site
981540003934	ATP binding site [chemical binding]; other site
981540003935	Q-loop/lid; other site
981540003936	ABC transporter signature motif; other site
981540003937	Walker B; other site
981540003938	D-loop; other site
981540003939	H-loop/switch region; other site
981540003940	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
981540003941	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
981540003942	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
981540003943	Walker A/P-loop; other site
981540003944	ATP binding site [chemical binding]; other site
981540003945	Q-loop/lid; other site
981540003946	ABC transporter signature motif; other site
981540003947	Walker B; other site
981540003948	D-loop; other site
981540003949	H-loop/switch region; other site
981540003950	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
981540003951	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
981540003952	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
981540003953	ABC transporter; Region: ABC_tran_2; pfam12848
981540003954	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
981540003955	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
981540003956	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
981540003957	active site
981540003958	NTP binding site [chemical binding]; other site
981540003959	metal binding triad [ion binding]; metal-binding site
981540003960	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
981540003961	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
981540003962	dihydrodipicolinate reductase; Provisional; Region: PRK00048
981540003963	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
981540003964	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
981540003965	EDD domain protein, DegV family; Region: DegV; TIGR00762
981540003966	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
981540003967	Protein of unknown function (DUF1149); Region: DUF1149; pfam06619
981540003968	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
981540003969	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK12315
981540003970	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
981540003971	TPP-binding site; other site
981540003972	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
981540003973	PYR/PP interface [polypeptide binding]; other site
981540003974	dimer interface [polypeptide binding]; other site
981540003975	TPP binding site [chemical binding]; other site
981540003976	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
981540003977	truncated hypothetical protein
981540003978	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
981540003979	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
981540003980	active site
981540003981	catalytic tetrad [active]
981540003982	truncated predicted membrane protein
981540003983	bifunctional homocysteine S-methyltransferase/5,10-methylenetetrahydrofolate reductase protein; Reviewed; Region: PRK08645
981540003984	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
981540003985	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
981540003986	FAD binding site [chemical binding]; other site
981540003987	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
981540003988	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
981540003989	THF binding site; other site
981540003990	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
981540003991	substrate binding site [chemical binding]; other site
981540003992	THF binding site; other site
981540003993	zinc-binding site [ion binding]; other site
981540003994	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
981540003995	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
981540003996	active site
981540003997	phosphorylation site [posttranslational modification]
981540003998	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
981540003999	active site
981540004000	P-loop; other site
981540004001	phosphorylation site [posttranslational modification]
981540004002	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
981540004003	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
981540004004	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
981540004005	putative substrate binding site [chemical binding]; other site
981540004006	putative ATP binding site [chemical binding]; other site
981540004007	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
981540004008	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
981540004009	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
981540004010	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
981540004011	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
981540004012	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
981540004013	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
981540004014	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
981540004015	RimM N-terminal domain; Region: RimM; pfam01782
981540004016	PRC-barrel domain; Region: PRC; pfam05239
981540004017	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
981540004018	KH domain; Region: KH_4; pfam13083
981540004019	G-X-X-G motif; other site
981540004020	Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228
981540004021	Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782
981540004022	Fic family protein [Function unknown]; Region: COG3177
981540004023	Fic/DOC family; Region: Fic; pfam02661
981540004024	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
981540004025	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
981540004026	P-loop; other site
981540004027	Magnesium ion binding site [ion binding]; other site
981540004028	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
981540004029	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
981540004030	multiple promoter invertase; Provisional; Region: mpi; PRK13413
981540004031	catalytic residues [active]
981540004032	catalytic nucleophile [active]
981540004033	Presynaptic Site I dimer interface [polypeptide binding]; other site
981540004034	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
981540004035	Synaptic Flat tetramer interface [polypeptide binding]; other site
981540004036	Synaptic Site I dimer interface [polypeptide binding]; other site
981540004037	DNA binding site [nucleotide binding]
981540004038	Homeodomain-like domain; Region: HTH_23; cl17451
981540004039	truncated relaxase
981540004040	truncated transposon associated hypothetical protein
981540004041	truncated transposon associated hypothetical protein
981540004042	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
981540004043	Topoisomerase IA [DNA replication, recombination, and repair]; Region: TopA; COG0550
981540004044	active site
981540004045	metal binding site [ion binding]; metal-binding site
981540004046	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
981540004047	domain I; other site
981540004048	DNA binding groove [nucleotide binding]
981540004049	phosphate binding site [ion binding]; other site
981540004050	domain II; other site
981540004051	domain III; other site
981540004052	nucleotide binding site [chemical binding]; other site
981540004053	catalytic site [active]
981540004054	domain IV; other site
981540004055	AAA-like domain; Region: AAA_10; pfam12846
981540004056	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
981540004057	Protein of unknown function (DUF3801); Region: DUF3801; pfam12687
981540004058	V-type ATP synthase subunit I; Validated; Region: PRK05771
981540004059	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
981540004060	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
981540004061	dimer interface [polypeptide binding]; other site
981540004062	ssDNA binding site [nucleotide binding]; other site
981540004063	tetramer (dimer of dimers) interface [polypeptide binding]; other site
981540004064	truncated Tn5252 Orf28
981540004065	truncated signal peptide containing protein
981540004066	Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517
981540004067	Uncharacterized conserved protein [Function unknown]; Region: COG0398
981540004068	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
981540004069	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
981540004070	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
981540004071	FtsX-like permease family; Region: FtsX; pfam02687
981540004072	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
981540004073	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
981540004074	Walker A/P-loop; other site
981540004075	ATP binding site [chemical binding]; other site
981540004076	Q-loop/lid; other site
981540004077	ABC transporter signature motif; other site
981540004078	Walker B; other site
981540004079	D-loop; other site
981540004080	H-loop/switch region; other site
981540004081	HlyD family secretion protein; Region: HlyD_3; pfam13437
981540004082	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
981540004083	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
981540004084	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
981540004085	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
981540004086	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
981540004087	ATP-grasp domain; Region: ATP-grasp_4; cl17255
981540004088	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
981540004089	IMP binding site; other site
981540004090	dimer interface [polypeptide binding]; other site
981540004091	interdomain contacts; other site
981540004092	partial ornithine binding site; other site
981540004093	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
981540004094	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
981540004095	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
981540004096	catalytic site [active]
981540004097	subunit interface [polypeptide binding]; other site
981540004098	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
981540004099	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
981540004100	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
981540004101	uracil transporter; Provisional; Region: PRK10720
981540004102	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
981540004103	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
981540004104	active site
981540004105	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
981540004106	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
981540004107	RNA binding surface [nucleotide binding]; other site
981540004108	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
981540004109	active site
981540004110	lipoprotein signal peptidase; Provisional; Region: PRK14797
981540004111	lipoprotein signal peptidase; Provisional; Region: PRK14787
981540004112	Transcriptional regulator [Transcription]; Region: LysR; COG0583
981540004113	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
981540004114	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
981540004115	dimerization interface [polypeptide binding]; other site
981540004116	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
981540004117	Protein of unknown function (DUF464); Region: DUF464; pfam04327
981540004118	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
981540004119	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
981540004120	Coenzyme A binding pocket [chemical binding]; other site
981540004121	Putative enzyme of poly-gamma-glutamate biosynthesis (capsule formation) [Cell envelope biogenesis, outer membrane]; Region: PgsA; COG2843
981540004122	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
981540004123	putative active site [active]
981540004124	putative metal binding site [ion binding]; other site
981540004125	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
981540004126	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
981540004127	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
981540004128	Ligand Binding Site [chemical binding]; other site
981540004129	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
981540004130	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
981540004131	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
981540004132	catalytic residue [active]
981540004133	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
981540004134	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
981540004135	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
981540004136	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
981540004137	tetramer (dimer of dimers) interface [polypeptide binding]; other site
981540004138	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
981540004139	NAD binding site [chemical binding]; other site
981540004140	dimer interface [polypeptide binding]; other site
981540004141	substrate binding site [chemical binding]; other site
981540004142	hypothetical protein; Provisional; Region: PRK13676
981540004143	prephenate dehydrogenase; Validated; Region: PRK06545
981540004144	prephenate dehydrogenase; Validated; Region: PRK08507
981540004145	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
981540004146	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
981540004147	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
981540004148	Tetramer interface [polypeptide binding]; other site
981540004149	active site
981540004150	FMN-binding site [chemical binding]; other site
981540004151	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
981540004152	active site
981540004153	dimer interface [polypeptide binding]; other site
981540004154	metal binding site [ion binding]; metal-binding site
981540004155	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
981540004156	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
981540004157	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
981540004158	shikimate binding site; other site
981540004159	NAD(P) binding site [chemical binding]; other site
981540004160	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
981540004161	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
981540004162	active site
981540004163	catalytic residue [active]
981540004164	dimer interface [polypeptide binding]; other site
981540004165	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
981540004166	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
981540004167	putative RNA binding site [nucleotide binding]; other site
981540004168	Methyltransferase domain; Region: Methyltransf_26; pfam13659
981540004169	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
981540004170	Sulfatase; Region: Sulfatase; pfam00884
981540004171	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
981540004172	23S rRNA binding site [nucleotide binding]; other site
981540004173	L21 binding site [polypeptide binding]; other site
981540004174	L13 binding site [polypeptide binding]; other site
981540004175	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
981540004176	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
981540004177	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
981540004178	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
981540004179	cytidylate kinase; Provisional; Region: cmk; PRK00023
981540004180	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
981540004181	CMP-binding site; other site
981540004182	The sites determining sugar specificity; other site
981540004183	peptidase T; Region: peptidase-T; TIGR01882
981540004184	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
981540004185	metal binding site [ion binding]; metal-binding site
981540004186	dimer interface [polypeptide binding]; other site
981540004187	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
981540004188	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
981540004189	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
981540004190	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
981540004191	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
981540004192	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
981540004193	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
981540004194	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
981540004195	active site
981540004196	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
981540004197	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
981540004198	GBS Bsp-like repeat; Region: GBS_Bsp-like; pfam08481
981540004199	Surface antigen [General function prediction only]; Region: COG3942
981540004200	CHAP domain; Region: CHAP; pfam05257
981540004201	conserved hypothetical integral membrane protein; Region: TIGR03766
981540004202	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
981540004203	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
981540004204	Ligand binding site; other site
981540004205	Putative Catalytic site; other site
981540004206	DXD motif; other site
981540004207	Glucosyl transferase GtrII; Region: Glucos_trans_II; pfam14264
981540004208	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
981540004209	Sulfatase; Region: Sulfatase; pfam00884
981540004210	Rhamnan synthesis protein F; Region: RgpF; pfam05045
981540004211	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
981540004212	Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535
981540004213	active site
981540004214	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
981540004215	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
981540004216	Walker A/P-loop; other site
981540004217	ATP binding site [chemical binding]; other site
981540004218	Q-loop/lid; other site
981540004219	ABC transporter signature motif; other site
981540004220	Walker B; other site
981540004221	D-loop; other site
981540004222	H-loop/switch region; other site
981540004223	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
981540004224	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
981540004225	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
981540004226	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
981540004227	Probable Catalytic site; other site
981540004228	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955
981540004229	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
981540004230	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
981540004231	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
981540004232	NADP binding site [chemical binding]; other site
981540004233	active site
981540004234	putative substrate binding site [chemical binding]; other site
981540004235	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
981540004236	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
981540004237	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
981540004238	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
981540004239	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
981540004240	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
981540004241	DNA binding residues [nucleotide binding]
981540004242	DNA primase; Validated; Region: dnaG; PRK05667
981540004243	CHC2 zinc finger; Region: zf-CHC2; pfam01807
981540004244	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
981540004245	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
981540004246	active site
981540004247	metal binding site [ion binding]; metal-binding site
981540004248	interdomain interaction site; other site
981540004249	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
981540004250	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
981540004251	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
981540004252	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
981540004253	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
981540004254	substrate binding pocket [chemical binding]; other site
981540004255	membrane-bound complex binding site; other site
981540004256	hinge residues; other site
981540004257	transaminase; Validated; Region: PRK07324
981540004258	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
981540004259	pyridoxal 5'-phosphate binding site [chemical binding]; other site
981540004260	homodimer interface [polypeptide binding]; other site
981540004261	catalytic residue [active]
981540004262	truncated polar amino acid transport system substrate-binding protein
981540004263	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
981540004264	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
981540004265	substrate binding pocket [chemical binding]; other site
981540004266	membrane-bound complex binding site; other site
981540004267	hinge residues; other site
981540004268	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
981540004269	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
981540004270	4-alpha-glucanotransferase; Provisional; Region: PRK14508
981540004271	Transcriptional regulators [Transcription]; Region: PurR; COG1609
981540004272	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
981540004273	DNA binding site [nucleotide binding]
981540004274	domain linker motif; other site
981540004275	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
981540004276	putative dimerization interface [polypeptide binding]; other site
981540004277	putative ligand binding site [chemical binding]; other site
981540004278	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
981540004279	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
981540004280	dimer interface [polypeptide binding]; other site
981540004281	conserved gate region; other site
981540004282	putative PBP binding loops; other site
981540004283	ABC-ATPase subunit interface; other site
981540004284	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
981540004285	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
981540004286	dimer interface [polypeptide binding]; other site
981540004287	conserved gate region; other site
981540004288	putative PBP binding loops; other site
981540004289	ABC-ATPase subunit interface; other site
981540004290	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
981540004291	putative active site [active]
981540004292	nucleotide binding site [chemical binding]; other site
981540004293	nudix motif; other site
981540004294	putative metal binding site [ion binding]; other site
981540004295	excinuclease ABC subunit B; Provisional; Region: PRK05298
981540004296	Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286
981540004297	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
981540004298	ATP-binding site [chemical binding]; other site
981540004299	ATP binding site [chemical binding]; other site
981540004300	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
981540004301	nucleotide binding region [chemical binding]; other site
981540004302	ATP-binding site [chemical binding]; other site
981540004303	Ultra-violet resistance protein B; Region: UvrB; pfam12344
981540004304	UvrB/uvrC motif; Region: UVR; pfam02151
981540004305	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
981540004306	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
981540004307	substrate binding pocket [chemical binding]; other site
981540004308	membrane-bound complex binding site; other site
981540004309	hinge residues; other site
981540004310	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
981540004311	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
981540004312	substrate binding pocket [chemical binding]; other site
981540004313	membrane-bound complex binding site; other site
981540004314	hinge residues; other site
981540004315	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
981540004316	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
981540004317	dimer interface [polypeptide binding]; other site
981540004318	conserved gate region; other site
981540004319	putative PBP binding loops; other site
981540004320	ABC-ATPase subunit interface; other site
981540004321	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
981540004322	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
981540004323	Walker A/P-loop; other site
981540004324	ATP binding site [chemical binding]; other site
981540004325	Q-loop/lid; other site
981540004326	ABC transporter signature motif; other site
981540004327	Walker B; other site
981540004328	D-loop; other site
981540004329	H-loop/switch region; other site
981540004330	truncated ABC transporter, ATP-binding protein
981540004331	truncated ABC transporter, ATP-binding protein
981540004332	truncated GTP-binding protein
981540004333	truncated GTP-binding protein
981540004334	truncated predicted membrane protein
981540004335	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
981540004336	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
981540004337	RNA binding surface [nucleotide binding]; other site
981540004338	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
981540004339	active site
981540004340	uracil binding [chemical binding]; other site
981540004341	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
981540004342	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
981540004343	peptide binding site [polypeptide binding]; other site
981540004344	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
981540004345	beta-galactosidase; Region: BGL; TIGR03356
981540004346	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
981540004347	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
981540004348	active site turn [active]
981540004349	phosphorylation site [posttranslational modification]
981540004350	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
981540004351	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
981540004352	HPr interaction site; other site
981540004353	glycerol kinase (GK) interaction site [polypeptide binding]; other site
981540004354	active site
981540004355	phosphorylation site [posttranslational modification]
981540004356	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
981540004357	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
981540004358	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
981540004359	putative active site [active]
981540004360	Protein of unknown function (DUF1706); Region: DUF1706; pfam08020
981540004361	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
981540004362	Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269
981540004363	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
981540004364	S-adenosylmethionine binding site [chemical binding]; other site
981540004365	Transcriptional regulator [Transcription]; Region: LytR; COG1316
981540004366	prephenate dehydratase; Provisional; Region: PRK11898
981540004367	Prephenate dehydratase; Region: PDT; pfam00800
981540004368	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
981540004369	putative L-Phe binding site [chemical binding]; other site
981540004370	Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703
981540004371	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
981540004372	ADP binding site [chemical binding]; other site
981540004373	magnesium binding site [ion binding]; other site
981540004374	putative shikimate binding site; other site
981540004375	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
981540004376	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
981540004377	hinge; other site
981540004378	active site
981540004379	GTP-binding protein LepA; Provisional; Region: PRK05433
981540004380	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
981540004381	G1 box; other site
981540004382	putative GEF interaction site [polypeptide binding]; other site
981540004383	GTP/Mg2+ binding site [chemical binding]; other site
981540004384	Switch I region; other site
981540004385	G2 box; other site
981540004386	G3 box; other site
981540004387	Switch II region; other site
981540004388	G4 box; other site
981540004389	G5 box; other site
981540004390	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
981540004391	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
981540004392	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
981540004393	Stu0660-like CRISPR/Cas system-associated protein Csn2; Region: Stu0660_Csn2; cd12217
981540004394	tetramer interface [polypeptide binding]; other site
981540004395	putative DNA binding site [nucleotide binding]; other site
981540004396	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09638
981540004397	CRISPR/Cas system-associated protein Cas1; Region: Cas1_II; cd09720
981540004398	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
981540004399	CRISPR-associated protein Cas9/Csn1, subtype II/NMEMI; Region: cas_Csn1; TIGR01865
981540004400	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
981540004401	active site
981540004402	multimer interface [polypeptide binding]; other site
981540004403	truncated transposase IS3/IS911 family protein
981540004404	truncated transposase IS3/IS911 family protein
981540004405	putative transposase OrfB; Reviewed; Region: PHA02517
981540004406	HTH-like domain; Region: HTH_21; pfam13276
981540004407	Integrase core domain; Region: rve; pfam00665
981540004408	Integrase core domain; Region: rve_3; pfam13683
981540004409	Predicted membrane protein [Function unknown]; Region: COG4478
981540004410	HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2
981540004411	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
981540004412	active site
981540004413	motif I; other site
981540004414	motif II; other site
981540004415	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
981540004416	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
981540004417	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
981540004418	nudix motif; other site
981540004419	Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643
981540004420	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
981540004421	active site
981540004422	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
981540004423	active site 2 [active]
981540004424	active site 1 [active]
981540004425	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
981540004426	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
981540004427	FeS/SAM binding site; other site
981540004428	HemN C-terminal domain; Region: HemN_C; pfam06969
981540004429	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
981540004430	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
981540004431	active site
981540004432	substrate binding site [chemical binding]; other site
981540004433	metal binding site [ion binding]; metal-binding site
981540004434	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
981540004435	YbbR-like protein; Region: YbbR; pfam07949
981540004436	Uncharacterized conserved protein [Function unknown]; Region: COG1624
981540004437	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
981540004438	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
981540004439	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
981540004440	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
981540004441	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
981540004442	catalytic triad [active]
981540004443	enolase; Provisional; Region: eno; PRK00077
981540004444	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
981540004445	dimer interface [polypeptide binding]; other site
981540004446	metal binding site [ion binding]; metal-binding site
981540004447	substrate binding pocket [chemical binding]; other site
981540004448	Protein of unknown function (DUF1694); Region: DUF1694; pfam07997
981540004449	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
981540004450	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
981540004451	nudix motif; other site
981540004452	Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523
981540004453	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
981540004454	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
981540004455	Ca binding site [ion binding]; other site
981540004456	active site
981540004457	catalytic site [active]
981540004458	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
981540004459	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
981540004460	metal binding site [ion binding]; metal-binding site
981540004461	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
981540004462	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
981540004463	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
981540004464	substrate binding site [chemical binding]; other site
981540004465	glutamase interaction surface [polypeptide binding]; other site
981540004466	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
981540004467	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
981540004468	catalytic residues [active]
981540004469	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
981540004470	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
981540004471	putative active site [active]
981540004472	oxyanion strand; other site
981540004473	catalytic triad [active]
981540004474	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
981540004475	putative active site pocket [active]
981540004476	4-fold oligomerization interface [polypeptide binding]; other site
981540004477	metal binding residues [ion binding]; metal-binding site
981540004478	3-fold/trimer interface [polypeptide binding]; other site
981540004479	phosphoserine phosphatase SerB; Region: serB; TIGR00338
981540004480	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
981540004481	motif II; other site
981540004482	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
981540004483	histidinol dehydrogenase; Region: hisD; TIGR00069
981540004484	NAD binding site [chemical binding]; other site
981540004485	dimerization interface [polypeptide binding]; other site
981540004486	product binding site; other site
981540004487	substrate binding site [chemical binding]; other site
981540004488	zinc binding site [ion binding]; other site
981540004489	catalytic residues [active]
981540004490	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
981540004491	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
981540004492	ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443
981540004493	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
981540004494	dimer interface [polypeptide binding]; other site
981540004495	motif 1; other site
981540004496	active site
981540004497	motif 2; other site
981540004498	motif 3; other site
981540004499	Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079
981540004500	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
981540004501	pyridoxal 5'-phosphate binding site [chemical binding]; other site
981540004502	homodimer interface [polypeptide binding]; other site
981540004503	catalytic residue [active]
981540004504	truncated S-adenosylhomocysteine/5'-methylthioadenosine nucleosidase
981540004505	septation ring formation regulator EzrA; Provisional; Region: PRK04778
981540004506	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
981540004507	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
981540004508	Mg2+ binding site [ion binding]; other site
981540004509	G-X-G motif; other site
981540004510	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
981540004511	anchoring element; other site
981540004512	dimer interface [polypeptide binding]; other site
981540004513	ATP binding site [chemical binding]; other site
981540004514	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
981540004515	active site
981540004516	putative metal-binding site [ion binding]; other site
981540004517	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
981540004518	haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549
981540004519	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
981540004520	motif II; other site
981540004521	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
981540004522	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
981540004523	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915
981540004524	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
981540004525	Cl- selectivity filter; other site
981540004526	Cl- binding residues [ion binding]; other site
981540004527	pore gating glutamate residue; other site
981540004528	dimer interface [polypeptide binding]; other site
981540004529	hypothetical protein; Provisional; Region: PRK07248
981540004530	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
981540004531	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
981540004532	FeS assembly protein SufB; Region: sufB; TIGR01980
981540004533	flavodoxin; Validated; Region: PRK07308
981540004534	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
981540004535	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
981540004536	active site
981540004537	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
981540004538	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
981540004539	putative dimer interface [polypeptide binding]; other site
981540004540	putative anticodon binding site; other site
981540004541	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
981540004542	homodimer interface [polypeptide binding]; other site
981540004543	motif 1; other site
981540004544	motif 2; other site
981540004545	active site
981540004546	motif 3; other site
981540004547	Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394
981540004548	aspartate aminotransferase; Provisional; Region: PRK05764
981540004549	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
981540004550	pyridoxal 5'-phosphate binding site [chemical binding]; other site
981540004551	homodimer interface [polypeptide binding]; other site
981540004552	catalytic residue [active]
981540004553	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353
981540004554	bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK07246
981540004555	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
981540004556	active site
981540004557	catalytic site [active]
981540004558	substrate binding site [chemical binding]; other site
981540004559	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
981540004560	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
981540004561	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
981540004562	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
981540004563	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
981540004564	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
981540004565	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
981540004566	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
981540004567	Walker A/P-loop; other site
981540004568	ATP binding site [chemical binding]; other site
981540004569	Q-loop/lid; other site
981540004570	ABC transporter signature motif; other site
981540004571	Walker B; other site
981540004572	D-loop; other site
981540004573	H-loop/switch region; other site
981540004574	PCRF domain; Region: PCRF; pfam03462
981540004575	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
981540004576	RF-1 domain; Region: RF-1; pfam00472
981540004577	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
981540004578	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
981540004579	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
981540004580	motif II; other site
981540004581	putative phosphoesterase; Region: acc_ester; TIGR03729
981540004582	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
981540004583	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
981540004584	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
981540004585	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
981540004586	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
981540004587	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
981540004588	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
981540004589	Domain of unknown function (DUF1934); Region: DUF1934; pfam09148
981540004590	truncated conserved hypothetical protein
981540004591	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
981540004592	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
981540004593	Zn2+ binding site [ion binding]; other site
981540004594	Mg2+ binding site [ion binding]; other site
981540004595	sugar phosphate phosphatase; Provisional; Region: PRK10513
981540004596	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
981540004597	active site
981540004598	motif I; other site
981540004599	motif II; other site
981540004600	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
981540004601	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
981540004602	FemAB family; Region: FemAB; pfam02388
981540004603	FemAB family; Region: FemAB; pfam02388
981540004604	U3 small nucleolar ribonucleoprotein component [Translation, ribosomal structure and biogenesis]; Region: Mpp10; COG5384
981540004605	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
981540004606	triosephosphate isomerase; Provisional; Region: PRK14567
981540004607	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
981540004608	substrate binding site [chemical binding]; other site
981540004609	dimer interface [polypeptide binding]; other site
981540004610	catalytic triad [active]
981540004611	elongation factor Tu; Reviewed; Region: PRK00049
981540004612	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
981540004613	G1 box; other site
981540004614	GEF interaction site [polypeptide binding]; other site
981540004615	GTP/Mg2+ binding site [chemical binding]; other site
981540004616	Switch I region; other site
981540004617	G2 box; other site
981540004618	G3 box; other site
981540004619	Switch II region; other site
981540004620	G4 box; other site
981540004621	G5 box; other site
981540004622	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
981540004623	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
981540004624	Antibiotic Binding Site [chemical binding]; other site
981540004625	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
981540004626	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
981540004627	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
981540004628	oligoendopeptidase F; Region: pepF; TIGR00181
981540004629	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
981540004630	Zn binding site [ion binding]; other site
981540004631	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
981540004632	catalytic residues [active]
981540004633	dimer interface [polypeptide binding]; other site
981540004634	PlyB is a bacteriophage endolysin that displays potent lytic activity toward Bacillus anthracis.  PlyB has an N-terminal glycosyl hydrolase family 25 (GH25) catalytic domain and a C-terminal bacterial SH3-like domain, SH3b.  Both domains are required for...; Region: GH25_PlyB-like; cd06523
981540004635	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
981540004636	active site
981540004637	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
981540004638	amidase catalytic site [active]
981540004639	Zn binding residues [ion binding]; other site
981540004640	substrate binding site [chemical binding]; other site
981540004641	truncated putative transcription regulator
981540004642	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
981540004643	catalytic core [active]
981540004644	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
981540004645	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
981540004646	motif II; other site
981540004647	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
981540004648	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
981540004649	dimer interface [polypeptide binding]; other site
981540004650	putative anticodon binding site; other site
981540004651	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
981540004652	motif 1; other site
981540004653	active site
981540004654	motif 2; other site
981540004655	motif 3; other site
981540004656	truncated TetR family transcriptional regulator
981540004657	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
981540004658	Myb-like DNA-binding domain; Region: Myb_DNA-bind_6; pfam13921
981540004659	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
981540004660	active site
981540004661	motif I; other site
981540004662	motif II; other site
981540004663	truncated putative biotin biosynthesis protein
981540004664	Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901
981540004665	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
981540004666	Peptidase family U32; Region: Peptidase_U32; pfam01136
981540004667	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
981540004668	Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275
981540004669	Peptidase family U32; Region: Peptidase_U32; pfam01136
981540004670	Protein of unknown function (DUF3270); Region: DUF3270; pfam11674
981540004671	Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768
981540004672	Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790
981540004673	HPr kinase/phosphorylase; Provisional; Region: PRK05428
981540004674	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
981540004675	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
981540004676	Hpr binding site; other site
981540004677	active site
981540004678	homohexamer subunit interaction site [polypeptide binding]; other site
981540004679	PspC domain; Region: PspC; pfam04024
981540004680	hypothetical protein; Provisional; Region: PRK04351
981540004681	SprT homologues; Region: SprT; cl01182
981540004682	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
981540004683	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
981540004684	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
981540004685	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
981540004686	RNA binding site [nucleotide binding]; other site
981540004687	Predicted permeases [General function prediction only]; Region: COG0701
981540004688	Predicted membrane protein [Function unknown]; Region: COG3689
981540004689	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
981540004690	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR2; cd08268
981540004691	putative NAD(P) binding site [chemical binding]; other site
981540004692	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
981540004693	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
981540004694	DNA binding residues [nucleotide binding]
981540004695	putative dimer interface [polypeptide binding]; other site
981540004696	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
981540004697	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
981540004698	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
981540004699	P loop; other site
981540004700	GTP binding site [chemical binding]; other site
981540004701	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
981540004702	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
981540004703	active site
981540004704	motif I; other site
981540004705	motif II; other site
981540004706	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
981540004707	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
981540004708	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
981540004709	active site
981540004710	motif I; other site
981540004711	motif II; other site
981540004712	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
981540004713	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
981540004714	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
981540004715	Walker A/P-loop; other site
981540004716	ATP binding site [chemical binding]; other site
981540004717	Q-loop/lid; other site
981540004718	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
981540004719	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
981540004720	ABC transporter signature motif; other site
981540004721	Walker B; other site
981540004722	D-loop; other site
981540004723	H-loop/switch region; other site
981540004724	ribonuclease III; Reviewed; Region: rnc; PRK00102
981540004725	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
981540004726	dimerization interface [polypeptide binding]; other site
981540004727	active site
981540004728	metal binding site [ion binding]; metal-binding site
981540004729	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
981540004730	dsRNA binding site [nucleotide binding]; other site
981540004731	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
981540004732	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
981540004733	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
981540004734	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
981540004735	dimer interface [polypeptide binding]; other site
981540004736	phosphorylation site [posttranslational modification]
981540004737	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
981540004738	ATP binding site [chemical binding]; other site
981540004739	Mg2+ binding site [ion binding]; other site
981540004740	G-X-G motif; other site
981540004741	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
981540004742	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
981540004743	active site
981540004744	phosphorylation site [posttranslational modification]
981540004745	intermolecular recognition site; other site
981540004746	dimerization interface [polypeptide binding]; other site
981540004747	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
981540004748	DNA binding site [nucleotide binding]
981540004749	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
981540004750	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
981540004751	Walker A/P-loop; other site
981540004752	ATP binding site [chemical binding]; other site
981540004753	Q-loop/lid; other site
981540004754	ABC transporter signature motif; other site
981540004755	Walker B; other site
981540004756	D-loop; other site
981540004757	H-loop/switch region; other site
981540004758	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
981540004759	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
981540004760	substrate binding pocket [chemical binding]; other site
981540004761	membrane-bound complex binding site; other site
981540004762	hinge residues; other site
981540004763	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
981540004764	dimer interface [polypeptide binding]; other site
981540004765	conserved gate region; other site
981540004766	putative PBP binding loops; other site
981540004767	ABC-ATPase subunit interface; other site
981540004768	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
981540004769	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
981540004770	dimer interface [polypeptide binding]; other site
981540004771	conserved gate region; other site
981540004772	putative PBP binding loops; other site
981540004773	ABC-ATPase subunit interface; other site
981540004774	Transposase; Region: DEDD_Tnp_IS110; pfam01548
981540004775	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
981540004776	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
981540004777	Uncharacterized conserved protein [Function unknown]; Region: COG0398
981540004778	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
981540004779	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
981540004780	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
981540004781	dimer interface [polypeptide binding]; other site
981540004782	phosphorylation site [posttranslational modification]
981540004783	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
981540004784	ATP binding site [chemical binding]; other site
981540004785	Mg2+ binding site [ion binding]; other site
981540004786	G-X-G motif; other site
981540004787	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
981540004788	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
981540004789	active site
981540004790	phosphorylation site [posttranslational modification]
981540004791	intermolecular recognition site; other site
981540004792	dimerization interface [polypeptide binding]; other site
981540004793	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
981540004794	DNA binding site [nucleotide binding]
981540004795	Protein of unknown function (DUF3114); Region: DUF3114; pfam11311
981540004796	truncated extracellular pectate lyase
981540004797	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
981540004798	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
981540004799	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
981540004800	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
981540004801	active site
981540004802	dimer interface [polypeptide binding]; other site
981540004803	motif 1; other site
981540004804	motif 2; other site
981540004805	motif 3; other site
981540004806	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
981540004807	anticodon binding site; other site
981540004808	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
981540004809	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
981540004810	putative ADP-binding pocket [chemical binding]; other site
981540004811	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
981540004812	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
981540004813	catabolite control protein A; Region: ccpA; TIGR01481
981540004814	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
981540004815	DNA binding site [nucleotide binding]
981540004816	domain linker motif; other site
981540004817	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
981540004818	dimerization interface [polypeptide binding]; other site
981540004819	effector binding site; other site
981540004820	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
981540004821	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
981540004822	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
981540004823	active site
981540004824	truncated amidohydrolases
981540004825	uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_1; cd10805
981540004826	putative active site [active]
981540004827	YdjC motif; other site
981540004828	Mg binding site [ion binding]; other site
981540004829	putative homodimer interface [polypeptide binding]; other site
981540004830	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
981540004831	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
981540004832	active site turn [active]
981540004833	phosphorylation site [posttranslational modification]
981540004834	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
981540004835	transcriptional antiterminator BglG; Provisional; Region: PRK09772
981540004836	CAT RNA binding domain; Region: CAT_RBD; smart01061
981540004837	PRD domain; Region: PRD; pfam00874
981540004838	PRD domain; Region: PRD; pfam00874
981540004839	truncated RpiR family regulatory protein
981540004840	3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163
981540004841	Flavoprotein; Region: Flavoprotein; pfam02441
981540004842	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977
981540004843	Transcriptional regulator [Transcription]; Region: LysR; COG0583
981540004844	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
981540004845	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
981540004846	dimerization interface [polypeptide binding]; other site
981540004847	Protein of unknown function (DUF554); Region: DUF554; pfam04474
981540004848	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
981540004849	beta-galactosidase; Region: BGL; TIGR03356
981540004850	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
981540004851	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
981540004852	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
981540004853	active site
981540004854	P-loop; other site
981540004855	phosphorylation site [posttranslational modification]
981540004856	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
981540004857	active site
981540004858	methionine cluster; other site
981540004859	phosphorylation site [posttranslational modification]
981540004860	metal binding site [ion binding]; metal-binding site
981540004861	Domain of unknown function (DUF3284); Region: DUF3284; pfam11687
981540004862	truncated transposase
981540004863	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
981540004864	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
981540004865	Walker A motif; other site
981540004866	ATP binding site [chemical binding]; other site
981540004867	Walker B motif; other site
981540004868	arginine finger; other site
981540004869	PRD domain; Region: PRD; pfam00874
981540004870	Transcriptional antiterminator [Transcription]; Region: COG3933
981540004871	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
981540004872	active pocket/dimerization site; other site
981540004873	active site
981540004874	phosphorylation site [posttranslational modification]
981540004875	PRD domain; Region: PRD; pfam00874
981540004876	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
981540004877	MarR family; Region: MarR_2; pfam12802
981540004878	truncated conserved hypothethical protein
981540004879	NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149
981540004880	dimer interface [polypeptide binding]; other site
981540004881	FMN binding site [chemical binding]; other site
981540004882	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
981540004883	beta-galactosidase; Region: BGL; TIGR03356
981540004884	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
981540004885	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
981540004886	active site turn [active]
981540004887	phosphorylation site [posttranslational modification]
981540004888	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
981540004889	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
981540004890	HPr interaction site; other site
981540004891	glycerol kinase (GK) interaction site [polypeptide binding]; other site
981540004892	active site
981540004893	phosphorylation site [posttranslational modification]
981540004894	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
981540004895	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
981540004896	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
981540004897	putative active site [active]
981540004898	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
981540004899	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
981540004900	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
981540004901	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
981540004902	Major Facilitator Superfamily; Region: MFS_1; pfam07690
981540004903	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
981540004904	putative substrate translocation pore; other site
981540004905	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
981540004906	Uncharacterized conserved protein [Function unknown]; Region: COG5441; cl02262
981540004907	Melibiase; Region: Melibiase; pfam02065
981540004908	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
981540004909	SmpB-tmRNA interface; other site
981540004910	ribonuclease R; Region: RNase_R; TIGR02063
981540004911	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
981540004912	RNB domain; Region: RNB; pfam00773
981540004913	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
981540004914	RNA binding site [nucleotide binding]; other site
981540004915	preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870
981540004916	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
981540004917	drug efflux system protein MdtG; Provisional; Region: PRK09874
981540004918	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
981540004919	putative substrate translocation pore; other site
981540004920	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
981540004921	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
981540004922	CoA-binding site [chemical binding]; other site
981540004923	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
981540004924	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
981540004925	DNA binding site [nucleotide binding]
981540004926	catalytic residue [active]
981540004927	H2TH interface [polypeptide binding]; other site
981540004928	putative catalytic residues [active]
981540004929	turnover-facilitating residue; other site
981540004930	intercalation triad [nucleotide binding]; other site
981540004931	8OG recognition residue [nucleotide binding]; other site
981540004932	putative reading head residues; other site
981540004933	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
981540004934	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
981540004935	GTPase Era; Reviewed; Region: era; PRK00089
981540004936	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
981540004937	G1 box; other site
981540004938	GTP/Mg2+ binding site [chemical binding]; other site
981540004939	Switch I region; other site
981540004940	G2 box; other site
981540004941	Switch II region; other site
981540004942	G3 box; other site
981540004943	G4 box; other site
981540004944	G5 box; other site
981540004945	KH domain; Region: KH_2; pfam07650
981540004946	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
981540004947	metal-binding heat shock protein; Provisional; Region: PRK00016
981540004948	truncated extracellular alpha amylase
981540004949	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
981540004950	PhoH-like protein; Region: PhoH; pfam02562
981540004951	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
981540004952	Major Facilitator Superfamily; Region: MFS_1; pfam07690
981540004953	putative substrate translocation pore; other site
981540004954	hypothetical protein; Provisional; Region: PRK13672
981540004955	methionine sulfoxide reductase A; Provisional; Region: PRK14054
981540004956	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
981540004957	S1 domain; Region: S1_2; pfam13509
981540004958	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
981540004959	ribosome recycling factor; Reviewed; Region: frr; PRK00083
981540004960	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
981540004961	hinge region; other site
981540004962	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
981540004963	putative nucleotide binding site [chemical binding]; other site
981540004964	uridine monophosphate binding site [chemical binding]; other site
981540004965	homohexameric interface [polypeptide binding]; other site
981540004966	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
981540004967	mRNA/rRNA interface [nucleotide binding]; other site
981540004968	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
981540004969	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
981540004970	23S rRNA interface [nucleotide binding]; other site
981540004971	L7/L12 interface [polypeptide binding]; other site
981540004972	putative thiostrepton binding site; other site
981540004973	L25 interface [polypeptide binding]; other site
981540004974	Protein of unknown function (DUF3397); Region: DUF3397; pfam11877
981540004975	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
981540004976	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
981540004977	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
981540004978	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
981540004979	Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652
981540004980	active site
981540004981	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
981540004982	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
981540004983	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
981540004984	FeoA domain; Region: FeoA; pfam04023
981540004985	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
981540004986	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
981540004987	nucleotide binding site [chemical binding]; other site
981540004988	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
981540004989	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
981540004990	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
981540004991	nucleotide binding site [chemical binding]; other site
981540004992	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
981540004993	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
981540004994	beta-galactosidase; Region: BGL; TIGR03356
981540004995	Protein of unknown function, DUF624; Region: DUF624; cl02369
981540004996	Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724
981540004997	Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins.  The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with...; Region: GH85_ENGase; cd06547
981540004998	putative active site [active]
981540004999	FOG: PKD repeat [General function prediction only]; Region: COG3291
981540005000	polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cd00146
981540005001	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
981540005002	sugar binding site [chemical binding]; other site
981540005003	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
981540005004	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
981540005005	Ca binding site [ion binding]; other site
981540005006	active site
981540005007	catalytic site [active]
981540005008	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
981540005009	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
981540005010	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
981540005011	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
981540005012	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
981540005013	dimer interface [polypeptide binding]; other site
981540005014	conserved gate region; other site
981540005015	putative PBP binding loops; other site
981540005016	ABC-ATPase subunit interface; other site
981540005017	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
981540005018	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
981540005019	dimer interface [polypeptide binding]; other site
981540005020	conserved gate region; other site
981540005021	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
981540005022	ABC-ATPase subunit interface; other site
981540005023	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
981540005024	N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814
981540005025	active site
981540005026	metal binding site [ion binding]; metal-binding site
981540005027	homodimer interface [polypeptide binding]; other site
981540005028	catalytic site [active]
981540005029	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
981540005030	truncated transposase
981540005031	Uncharacterized conserved protein [Function unknown]; Region: COG3538
981540005032	Protein of unknown function (DUF1237); Region: DUF1237; pfam06824
981540005033	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
981540005034	DNA-binding site [nucleotide binding]; DNA binding site
981540005035	Transcriptional regulators [Transcription]; Region: PurR; COG1609
981540005036	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
981540005037	ligand binding site [chemical binding]; other site
981540005038	dimerization interface [polypeptide binding]; other site
981540005039	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
981540005040	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
981540005041	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
981540005042	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
981540005043	DNA-directed RNA polymerase subunit B'; Validated; Region: PRK07225
981540005044	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
981540005045	dimer interface [polypeptide binding]; other site
981540005046	ADP-ribose binding site [chemical binding]; other site
981540005047	active site
981540005048	nudix motif; other site
981540005049	metal binding site [ion binding]; metal-binding site
981540005050	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
981540005051	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
981540005052	Substrate binding site; other site
981540005053	Mg++ binding site; other site
981540005054	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
981540005055	active site
981540005056	substrate binding site [chemical binding]; other site
981540005057	CoA binding site [chemical binding]; other site
981540005058	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
981540005059	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
981540005060	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
981540005061	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550
981540005062	classical (c) SDRs; Region: SDR_c; cd05233
981540005063	NAD(P) binding site [chemical binding]; other site
981540005064	active site
981540005065	Protein of unknown function (DUF2829); Region: DUF2829; pfam11195
981540005066	FemAB family; Region: FemAB; pfam02388
981540005067	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
981540005068	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
981540005069	active site
981540005070	HIGH motif; other site
981540005071	KMSKS motif; other site
981540005072	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
981540005073	tRNA binding surface [nucleotide binding]; other site
981540005074	anticodon binding site; other site
981540005075	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
981540005076	dimer interface [polypeptide binding]; other site
981540005077	putative tRNA-binding site [nucleotide binding]; other site
981540005078	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
981540005079	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
981540005080	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
981540005081	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
981540005082	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
981540005083	Predicted integral membrane protein [Function unknown]; Region: COG5658
981540005084	SdpI/YhfL protein family; Region: SdpI; pfam13630
981540005085	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
981540005086	dimerization interface [polypeptide binding]; other site
981540005087	putative DNA binding site [nucleotide binding]; other site
981540005088	putative Zn2+ binding site [ion binding]; other site
981540005089	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
981540005090	active site
981540005091	putative catalytic site [active]
981540005092	DNA binding site [nucleotide binding]
981540005093	putative phosphate binding site [ion binding]; other site
981540005094	metal binding site A [ion binding]; metal-binding site
981540005095	AP binding site [nucleotide binding]; other site
981540005096	metal binding site B [ion binding]; metal-binding site
981540005097	truncated major facilitator superfamily protein
981540005098	truncated LysR family transcriptional regulator
981540005099	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
981540005100	ArsC family; Region: ArsC; pfam03960
981540005101	putative ArsC-like catalytic residues; other site
981540005102	putative TRX-like catalytic residues [active]
981540005103	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
981540005104	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
981540005105	DNA binding site [nucleotide binding]
981540005106	active site
981540005107	truncated hypothetical protein
981540005108	Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_3; cd12174
981540005109	D-isomer specific 2-hydroxyacid dehydrogenase, catalytic domain; Region: 2-Hacid_dh; pfam00389
981540005110	putative ligand binding site [chemical binding]; other site
981540005111	putative NAD binding site [chemical binding]; other site
981540005112	putative catalytic site [active]
981540005113	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
981540005114	L-serine binding site [chemical binding]; other site
981540005115	ACT domain interface; other site
981540005116	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
981540005117	3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355
981540005118	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
981540005119	catalytic residue [active]
981540005120	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
981540005121	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
981540005122	Nitrogen regulatory protein P-II; Region: P-II; smart00938
981540005123	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
981540005124	Predicted methyltransferases [General function prediction only]; Region: COG0313
981540005125	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
981540005126	putative SAM binding site [chemical binding]; other site
981540005127	putative homodimer interface [polypeptide binding]; other site
981540005128	DNA replication intiation control protein YabA; Reviewed; Region: PRK13169
981540005129	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
981540005130	DNA polymerase III subunit delta'; Validated; Region: PRK07276
981540005131	DNA polymerase III subunit delta'; Validated; Region: PRK08485
981540005132	thymidylate kinase; Validated; Region: tmk; PRK00698
981540005133	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
981540005134	TMP-binding site; other site
981540005135	ATP-binding site [chemical binding]; other site
981540005136	FOG: CBS domain [General function prediction only]; Region: COG0517
981540005137	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc2; cd04585
981540005138	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116
981540005139	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
981540005140	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
981540005141	Walker A/P-loop; other site
981540005142	ATP binding site [chemical binding]; other site
981540005143	Q-loop/lid; other site
981540005144	ABC transporter signature motif; other site
981540005145	Walker B; other site
981540005146	D-loop; other site
981540005147	H-loop/switch region; other site
981540005148	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
981540005149	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
981540005150	Walker A/P-loop; other site
981540005151	ATP binding site [chemical binding]; other site
981540005152	Q-loop/lid; other site
981540005153	ABC transporter signature motif; other site
981540005154	Walker B; other site
981540005155	D-loop; other site
981540005156	H-loop/switch region; other site
981540005157	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
981540005158	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
981540005159	TM-ABC transporter signature motif; other site
981540005160	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
981540005161	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
981540005162	TM-ABC transporter signature motif; other site
981540005163	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
981540005164	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
981540005165	putative ligand binding site [chemical binding]; other site
981540005166	hypothetical protein; Provisional; Region: PRK02302
981540005167	Protein of unknown function (DUF964); Region: DUF964; pfam06133
981540005168	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
981540005169	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
981540005170	oligomer interface [polypeptide binding]; other site
981540005171	active site residues [active]
981540005172	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
981540005173	active site
981540005174	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
981540005175	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
981540005176	pyridoxal 5'-phosphate binding site [chemical binding]; other site
981540005177	homodimer interface [polypeptide binding]; other site
981540005178	catalytic residue [active]
981540005179	cystathionine gamma-synthase; Reviewed; Region: PRK07269
981540005180	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
981540005181	homodimer interface [polypeptide binding]; other site
981540005182	substrate-cofactor binding pocket; other site
981540005183	pyridoxal 5'-phosphate binding site [chemical binding]; other site
981540005184	catalytic residue [active]
981540005185	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
981540005186	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
981540005187	UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022
981540005188	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
981540005189	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
981540005190	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
981540005191	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
981540005192	Walker A/P-loop; other site
981540005193	ATP binding site [chemical binding]; other site
981540005194	Q-loop/lid; other site
981540005195	ABC transporter signature motif; other site
981540005196	Walker B; other site
981540005197	D-loop; other site
981540005198	H-loop/switch region; other site
981540005199	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
981540005200	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
981540005201	intersubunit interface [polypeptide binding]; other site
981540005202	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
981540005203	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
981540005204	ABC-ATPase subunit  interface; other site
981540005205	dimer interface [polypeptide binding]; other site
981540005206	putative PBP binding regions; other site
981540005207	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
981540005208	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
981540005209	ABC-ATPase subunit  interface; other site
981540005210	dimer interface [polypeptide binding]; other site
981540005211	putative PBP binding regions; other site
981540005212	Domain of unknown function (DUF1803); Region: DUF1803; pfam08820
981540005213	Domain of unknown function (DUF1803); Region: DUF1803; pfam08820
981540005214	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; pfam05708
981540005215	hypothetical protein; Validated; Region: PRK02101
981540005216	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
981540005217	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
981540005218	DHHA2 domain; Region: DHHA2; pfam02833
981540005219	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
981540005220	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
981540005221	FeS/SAM binding site; other site
981540005222	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
981540005223	Domain of unknown function DUF21; Region: DUF21; pfam01595
981540005224	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
981540005225	Transporter associated domain; Region: CorC_HlyC; smart01091
981540005226	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
981540005227	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
981540005228	Walker A/P-loop; other site
981540005229	ATP binding site [chemical binding]; other site
981540005230	Q-loop/lid; other site
981540005231	ABC transporter signature motif; other site
981540005232	Walker B; other site
981540005233	D-loop; other site
981540005234	H-loop/switch region; other site
981540005235	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
981540005236	Putative rRNA methylase; Region: rRNA_methylase; pfam06962
981540005237	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
981540005238	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
981540005239	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
981540005240	active site
981540005241	Predicted membrane protein [Function unknown]; Region: COG2510
981540005242	Predicted membrane protein [Function unknown]; Region: COG3601
981540005243	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
981540005244	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
981540005245	Amino acid permease; Region: AA_permease_2; pfam13520
981540005246	K+ potassium transporter; Region: K_trans; cl15781
981540005247	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
981540005248	TrkA-N domain; Region: TrkA_N; pfam02254
981540005249	TrkA-C domain; Region: TrkA_C; pfam02080
981540005250	TrkA-N domain; Region: TrkA_N; pfam02254
981540005251	TrkA-C domain; Region: TrkA_C; pfam02080
981540005252	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
981540005253	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
981540005254	hypothetical protein; Validated; Region: PRK00041
981540005255	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
981540005256	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
981540005257	RNA binding surface [nucleotide binding]; other site
981540005258	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
981540005259	active site
981540005260	segregation and condensation protein B; Reviewed; Region: scpB; PRK00135
981540005261	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
981540005262	site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436
981540005263	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
981540005264	active site
981540005265	Int/Topo IB signature motif; other site
981540005266	catalytic residues [active]
981540005267	DNA binding site [nucleotide binding]
981540005268	FOG: CBS domain [General function prediction only]; Region: COG0517
981540005269	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643
981540005270	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
981540005271	active site
981540005272	metal binding site [ion binding]; metal-binding site
981540005273	homotetramer interface [polypeptide binding]; other site
981540005274	putative deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein; Reviewed; Region: PRK02491
981540005275	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
981540005276	active site
981540005277	dimerization interface [polypeptide binding]; other site
981540005278	glutamate racemase; Provisional; Region: PRK00865
981540005279	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763
981540005280	Protein of unknown function (DUF3789); Region: DUF3789; pfam12664
981540005281	truncated conjugative transposon replication initiation factor
981540005282	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
981540005283	Protein of unknown function (DUF3781); Region: DUF3781; pfam12636
981540005284	A new structural DNA glycosylase; Region: AlkD_like; cl11434
981540005285	HEAT repeats; Region: HEAT_2; pfam13646
981540005286	active site
981540005287	TfoX N-terminal domain; Region: TfoX_N; pfam04993
981540005288	Protein of unknown function (DUF1697); Region: DUF1697; pfam08002
981540005289	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
981540005290	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
981540005291	active site
981540005292	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
981540005293	substrate binding site [chemical binding]; other site
981540005294	catalytic residues [active]
981540005295	dimer interface [polypeptide binding]; other site
981540005296	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
981540005297	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
981540005298	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
981540005299	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
981540005300	Zn2+ binding site [ion binding]; other site
981540005301	Mg2+ binding site [ion binding]; other site
981540005302	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
981540005303	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
981540005304	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
981540005305	galactoside permease; Reviewed; Region: lacY; PRK09528
981540005306	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
981540005307	putative substrate translocation pore; other site
981540005308	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
981540005309	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
981540005310	substrate binding [chemical binding]; other site
981540005311	active site
981540005312	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
981540005313	Transcriptional regulators [Transcription]; Region: PurR; COG1609
981540005314	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
981540005315	DNA binding site [nucleotide binding]
981540005316	domain linker motif; other site
981540005317	Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291
981540005318	dimerization interface [polypeptide binding]; other site
981540005319	ligand binding site [chemical binding]; other site
981540005320	sodium binding site [ion binding]; other site
981540005321	acylphosphatase; Provisional; Region: PRK14434
981540005322	OxaA-like protein precursor; Provisional; Region: PRK02463
981540005323	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
981540005324	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
981540005325	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
981540005326	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
981540005327	GNL3L/Grn1 putative GTPase; Region: GN3L_Grn1; pfam08701
981540005328	YceG-like family; Region: YceG; pfam02618
981540005329	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
981540005330	dimerization interface [polypeptide binding]; other site
981540005331	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
981540005332	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
981540005333	Coenzyme A binding pocket [chemical binding]; other site
981540005334	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
981540005335	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
981540005336	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
981540005337	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
981540005338	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
981540005339	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
981540005340	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
981540005341	ATP binding site [chemical binding]; other site
981540005342	putative Mg++ binding site [ion binding]; other site
981540005343	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
981540005344	nucleotide binding region [chemical binding]; other site
981540005345	ATP-binding site [chemical binding]; other site
981540005346	GTP-binding protein Der; Reviewed; Region: PRK00093
981540005347	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
981540005348	G1 box; other site
981540005349	GTP/Mg2+ binding site [chemical binding]; other site
981540005350	Switch I region; other site
981540005351	G2 box; other site
981540005352	Switch II region; other site
981540005353	G3 box; other site
981540005354	G4 box; other site
981540005355	G5 box; other site
981540005356	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
981540005357	G1 box; other site
981540005358	GTP/Mg2+ binding site [chemical binding]; other site
981540005359	Switch I region; other site
981540005360	G2 box; other site
981540005361	G3 box; other site
981540005362	Switch II region; other site
981540005363	G4 box; other site
981540005364	G5 box; other site
981540005365	primosomal protein DnaI; Reviewed; Region: PRK08939
981540005366	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
981540005367	RNA helicase; Region: RNA_helicase; pfam00910
981540005368	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
981540005369	Replication initiation and membrane attachment; Region: DnaB_2; cl12121
981540005370	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
981540005371	ATP cone domain; Region: ATP-cone; pfam03477
981540005372	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
981540005373	Integrase core domain; Region: rve; pfam00665
981540005374	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
981540005375	hypothetical protein; Provisional; Region: PRK06446
981540005376	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681
981540005377	metal binding site [ion binding]; metal-binding site
981540005378	dimer interface [polypeptide binding]; other site
981540005379	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
981540005380	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
981540005381	Walker A/P-loop; other site
981540005382	ATP binding site [chemical binding]; other site
981540005383	Q-loop/lid; other site
981540005384	ABC transporter signature motif; other site
981540005385	Walker B; other site
981540005386	D-loop; other site
981540005387	H-loop/switch region; other site
981540005388	NIL domain; Region: NIL; pfam09383
981540005389	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
981540005390	dimer interface [polypeptide binding]; other site
981540005391	conserved gate region; other site
981540005392	ABC-ATPase subunit interface; other site
981540005393	Predicted transcriptional regulator [Transcription]; Region: COG1959
981540005394	Transcriptional regulator; Region: Rrf2; pfam02082
981540005395	Transcriptional regulator; Region: Rrf2; cl17282
981540005396	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
981540005397	NADH(P)-binding; Region: NAD_binding_10; pfam13460
981540005398	NAD binding site [chemical binding]; other site
981540005399	substrate binding site [chemical binding]; other site
981540005400	putative active site [active]
981540005401	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
981540005402	serine/threonine transporter SstT; Provisional; Region: PRK13628
981540005403	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
981540005404	Uncharacterized conserved protein [Function unknown]; Region: COG1912
981540005405	hypothetical protein; Provisional; Region: PRK13661
981540005406	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
981540005407	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
981540005408	Walker A/P-loop; other site
981540005409	ATP binding site [chemical binding]; other site
981540005410	Q-loop/lid; other site
981540005411	ABC transporter signature motif; other site
981540005412	Walker B; other site
981540005413	D-loop; other site
981540005414	H-loop/switch region; other site
981540005415	ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558
981540005416	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
981540005417	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
981540005418	Walker A/P-loop; other site
981540005419	ATP binding site [chemical binding]; other site
981540005420	Q-loop/lid; other site
981540005421	ABC transporter signature motif; other site
981540005422	Walker B; other site
981540005423	D-loop; other site
981540005424	H-loop/switch region; other site
981540005425	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
981540005426	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
981540005427	TrkA-N domain; Region: TrkA_N; pfam02254
981540005428	TrkA-C domain; Region: TrkA_C; pfam02080
981540005429	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
981540005430	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
981540005431	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
981540005432	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
981540005433	S-adenosylmethionine binding site [chemical binding]; other site
981540005434	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
981540005435	heat shock protein HtpX; Provisional; Region: PRK04897
981540005436	Uncharacterized ACR, COG1399; Region: DUF177; cl00616
981540005437	Cna protein B-type domain; Region: Cna_B; pfam05738
981540005438	Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125
981540005439	Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125
981540005440	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
981540005441	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
981540005442	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
981540005443	sequence-specific DNA binding site [nucleotide binding]; other site
981540005444	salt bridge; other site
981540005445	Replication initiation factor; Region: Rep_trans; pfam02486
981540005446	Antirestriction protein (ArdA); Region: ArdA; pfam07275
981540005447	TcpE family; Region: TcpE; pfam12648
981540005448	AAA-like domain; Region: AAA_10; pfam12846
981540005449	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
981540005450	Haemolysin-III related; Region: HlyIII; cl03831
981540005451	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
981540005452	N-acetyl-D-glucosamine binding site [chemical binding]; other site
981540005453	catalytic residue [active]
981540005454	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
981540005455	NlpC/P60 family; Region: NLPC_P60; pfam00877
981540005456	Conjugative transposon protein TcpC; Region: TpcC; pfam12642
981540005457	truncated tetracycline resistance protein
981540005458	truncated tetracycline resistance protein
981540005459	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
981540005460	Major Facilitator Superfamily; Region: MFS_1; pfam07690
981540005461	putative substrate translocation pore; other site
981540005462	Plasmid recombination enzyme; Region: Mob_Pre; pfam01076
981540005463	truncated plasmid replication initiation protein
981540005464	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
981540005465	Integrase core domain; Region: rve; pfam00665
981540005466	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
981540005467	Integrase core domain; Region: rve; pfam00665
981540005468	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
981540005469	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
981540005470	substrate binding pocket [chemical binding]; other site
981540005471	membrane-bound complex binding site; other site
981540005472	hinge residues; other site
981540005473	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
981540005474	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
981540005475	metal binding site [ion binding]; metal-binding site
981540005476	truncated polar amino acid transport system substrate-binding protein
981540005477	Peptidase C26; Region: Peptidase_C26; pfam07722
981540005478	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
981540005479	catalytic triad [active]
981540005480	truncated conserved hypothetical protein
981540005481	truncated conserved hypothetical protein
981540005482	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
981540005483	triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269
981540005484	NADP binding site [chemical binding]; other site
981540005485	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
981540005486	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
981540005487	DNA binding residues [nucleotide binding]
981540005488	dimer interface [polypeptide binding]; other site
981540005489	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
981540005490	hypothetical protein; Provisional; Region: PRK13670
981540005491	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636
981540005492	Protein of unknown function DUF262; Region: DUF262; pfam03235
981540005493	Uncharacterized conserved protein [Function unknown]; Region: COG1479
981540005494	Protein of unknown function DUF262; Region: DUF262; pfam03235
981540005495	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
981540005496	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
981540005497	S-adenosylmethionine binding site [chemical binding]; other site
981540005498	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
981540005499	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
981540005500	Zn2+ binding site [ion binding]; other site
981540005501	Mg2+ binding site [ion binding]; other site
981540005502	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
981540005503	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
981540005504	active site
981540005505	(T/H)XGH motif; other site
981540005506	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
981540005507	GTPase YqeH; Provisional; Region: PRK13796
981540005508	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
981540005509	GTP/Mg2+ binding site [chemical binding]; other site
981540005510	G4 box; other site
981540005511	G5 box; other site
981540005512	G1 box; other site
981540005513	Switch I region; other site
981540005514	G2 box; other site
981540005515	G3 box; other site
981540005516	Switch II region; other site
981540005517	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
981540005518	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
981540005519	active site
981540005520	motif I; other site
981540005521	motif II; other site
981540005522	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
981540005523	Major Facilitator Superfamily; Region: MFS_1; pfam07690
981540005524	putative substrate translocation pore; other site
981540005525	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
981540005526	MarR family; Region: MarR_2; pfam12802
981540005527	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
981540005528	EamA-like transporter family; Region: EamA; pfam00892
981540005529	truncated aspartyl-tRNA(Asn)/glutamyl-tRNA (Gln) amidotransferase subunit B
981540005530	truncated aspartyl-tRNA(Asn)/glutamyl-tRNA (Gln) amidotransferase subunit B
981540005531	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
981540005532	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
981540005533	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
981540005534	Isochorismatase family; Region: Isochorismatase; pfam00857
981540005535	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
981540005536	catalytic triad [active]
981540005537	conserved cis-peptide bond; other site
981540005538	transcriptional repressor CodY; Validated; Region: PRK04158
981540005539	CodY GAF-like domain; Region: CodY; pfam06018
981540005540	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
981540005541	dimerization interface [polypeptide binding]; other site
981540005542	putative Zn2+ binding site [ion binding]; other site
981540005543	putative DNA binding site [nucleotide binding]; other site
981540005544	aminotransferase AlaT; Validated; Region: PRK09265
981540005545	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
981540005546	pyridoxal 5'-phosphate binding site [chemical binding]; other site
981540005547	homodimer interface [polypeptide binding]; other site
981540005548	catalytic residue [active]
981540005549	Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; cl01974
981540005550	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
981540005551	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
981540005552	active site
981540005553	catalytic site [active]
981540005554	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
981540005555	Ligand Binding Site [chemical binding]; other site
981540005556	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
981540005557	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
981540005558	active site
981540005559	motif I; other site
981540005560	motif II; other site
981540005561	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
981540005562	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
981540005563	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4696
981540005564	metal binding site [ion binding]; metal-binding site
981540005565	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
981540005566	active site
981540005567	homotetramer interface [polypeptide binding]; other site
981540005568	homodimer interface [polypeptide binding]; other site
981540005569	Predicted transcriptional regulator [Transcription]; Region: COG3655
981540005570	sequence-specific DNA binding site [nucleotide binding]; other site
981540005571	salt bridge; other site
981540005572	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
981540005573	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
981540005574	generic binding surface II; other site
981540005575	ssDNA binding site; other site
981540005576	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
981540005577	ATP binding site [chemical binding]; other site
981540005578	putative Mg++ binding site [ion binding]; other site
981540005579	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
981540005580	nucleotide binding region [chemical binding]; other site
981540005581	ATP-binding site [chemical binding]; other site
981540005582	alanine racemase; Reviewed; Region: alr; PRK00053
981540005583	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
981540005584	active site
981540005585	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
981540005586	dimer interface [polypeptide binding]; other site
981540005587	substrate binding site [chemical binding]; other site
981540005588	catalytic residues [active]
981540005589	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
981540005590	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; cl17260
981540005591	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
981540005592	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; cl17260
981540005593	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
981540005594	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
981540005595	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
981540005596	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
981540005597	nucleotide binding region [chemical binding]; other site
981540005598	ATP-binding site [chemical binding]; other site
981540005599	SEC-C motif; Region: SEC-C; pfam02810
981540005600	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
981540005601	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
981540005602	nucleotide binding site [chemical binding]; other site
981540005603	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
981540005604	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
981540005605	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
981540005606	active site turn [active]
981540005607	phosphorylation site [posttranslational modification]
981540005608	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
981540005609	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
981540005610	HPr interaction site; other site
981540005611	glycerol kinase (GK) interaction site [polypeptide binding]; other site
981540005612	active site
981540005613	phosphorylation site [posttranslational modification]
981540005614	sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322
981540005615	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
981540005616	substrate binding [chemical binding]; other site
981540005617	active site
981540005618	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
981540005619	Transcriptional regulators [Transcription]; Region: PurR; COG1609
981540005620	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
981540005621	DNA binding site [nucleotide binding]
981540005622	domain linker motif; other site
981540005623	Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291
981540005624	dimerization interface [polypeptide binding]; other site
981540005625	ligand binding site [chemical binding]; other site
981540005626	sodium binding site [ion binding]; other site
981540005627	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
981540005628	putative RNA binding site [nucleotide binding]; other site
981540005629	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
981540005630	elongation factor P; Validated; Region: PRK00529
981540005631	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
981540005632	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
981540005633	RNA binding site [nucleotide binding]; other site
981540005634	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
981540005635	RNA binding site [nucleotide binding]; other site
981540005636	truncated predicted membrane protein
981540005637	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
981540005638	catalytic motif [active]
981540005639	Zn binding site [ion binding]; other site
981540005640	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
981540005641	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
981540005642	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
981540005643	active site
981540005644	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
981540005645	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
981540005646	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
981540005647	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
981540005648	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
981540005649	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
981540005650	Cl binding site [ion binding]; other site
981540005651	oligomer interface [polypeptide binding]; other site
981540005652	Protein of unknown function (DUF1129); Region: DUF1129; cl11555
981540005653	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
981540005654	non-specific DNA binding site [nucleotide binding]; other site
981540005655	salt bridge; other site
981540005656	sequence-specific DNA binding site [nucleotide binding]; other site
981540005657	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
981540005658	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
981540005659	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
981540005660	dimer interface [polypeptide binding]; other site
981540005661	ssDNA binding site [nucleotide binding]; other site
981540005662	tetramer (dimer of dimers) interface [polypeptide binding]; other site
981540005663	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
981540005664	BioY family; Region: BioY; pfam02632
981540005665	AAA domain; Region: AAA_26; pfam13500
981540005666	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
981540005667	biotin synthase; Region: bioB; TIGR00433
981540005668	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
981540005669	FeS/SAM binding site; other site
981540005670	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
981540005671	alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317
981540005672	Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974
981540005673	catalytic residue [active]
981540005674	TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026
981540005675	catalytic residues [active]
981540005676	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
981540005677	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
981540005678	peroxiredoxin; Region: AhpC; TIGR03137
981540005679	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
981540005680	dimer interface [polypeptide binding]; other site
981540005681	decamer (pentamer of dimers) interface [polypeptide binding]; other site
981540005682	catalytic triad [active]
981540005683	peroxidatic and resolving cysteines [active]
981540005684	truncated AMP-binding enzyme
981540005685	truncated membrane-associated acyltransferase
981540005686	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
981540005687	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
981540005688	minor groove reading motif; other site
981540005689	helix-hairpin-helix signature motif; other site
981540005690	substrate binding pocket [chemical binding]; other site
981540005691	active site
981540005692	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
981540005693	DNA binding and oxoG recognition site [nucleotide binding]
981540005694	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; pfam04828
981540005695	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
981540005696	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
981540005697	putative substrate translocation pore; other site
981540005698	Predicted flavoprotein [General function prediction only]; Region: COG0431
981540005699	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
981540005700	Predicted flavoprotein [General function prediction only]; Region: COG0431
981540005701	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
981540005702	FMN-binding domain; Region: FMN_bind; pfam04205
981540005703	flavocytochrome c; Region: flavo_cyto_c; TIGR01813
981540005704	L-aspartate oxidase; Provisional; Region: PRK06175
981540005705	Protein of unknown function (DUF2992); Region: DUF2992; pfam11208
981540005706	fatty acyl-CoA reductase 2; Region: PLN02503
981540005707	Predicted membrane protein [Function unknown]; Region: COG2323
981540005708	Protein of unknown function (DUF3290); Region: DUF3290; pfam11694
981540005709	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
981540005710	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
981540005711	nucleotide binding site [chemical binding]; other site
981540005712	butyrate kinase; Region: butyr_kinase; TIGR02707
981540005713	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
981540005714	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
981540005715	putative substrate translocation pore; other site
981540005716	Major Facilitator Superfamily; Region: MFS_1; pfam07690
981540005717	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
981540005718	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
981540005719	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
981540005720	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
981540005721	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
981540005722	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287
981540005723	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
981540005724	catalytic Zn binding site [ion binding]; other site
981540005725	NAD(P) binding site [chemical binding]; other site
981540005726	structural Zn binding site [ion binding]; other site
981540005727	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
981540005728	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
981540005729	catalytic residues [active]
981540005730	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
981540005731	active site
981540005732	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
981540005733	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
981540005734	dimerization interface [polypeptide binding]; other site
981540005735	active site
981540005736	L-aspartate oxidase; Provisional; Region: PRK06175
981540005737	FAD binding domain; Region: FAD_binding_2; pfam00890
981540005738	Quinolinate synthetase A protein; Region: NadA; pfam02445
981540005739	Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: COG1193
981540005740	MutS domain III; Region: MutS_III; pfam05192
981540005741	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
981540005742	Walker A/P-loop; other site
981540005743	ATP binding site [chemical binding]; other site
981540005744	Q-loop/lid; other site
981540005745	ABC transporter signature motif; other site
981540005746	Walker B; other site
981540005747	D-loop; other site
981540005748	H-loop/switch region; other site
981540005749	Smr domain; Region: Smr; pfam01713
981540005750	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
981540005751	Colicin V production protein; Region: Colicin_V; pfam02674
981540005752	ribonuclease HIII; Provisional; Region: PRK00996
981540005753	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
981540005754	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
981540005755	RNA/DNA hybrid binding site [nucleotide binding]; other site
981540005756	active site
981540005757	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
981540005758	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
981540005759	Catalytic site [active]
981540005760	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
981540005761	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
981540005762	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
981540005763	AAA domain; Region: AAA_30; pfam13604
981540005764	Family description; Region: UvrD_C_2; pfam13538
981540005765	Predicted membrane protein [Function unknown]; Region: COG4684
981540005766	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
981540005767	active site
981540005768	DNA polymerase IV; Validated; Region: PRK02406
981540005769	DNA binding site [nucleotide binding]
981540005770	truncated pyruvate formate-lyase
981540005771	truncated pyruvate formate-lyase
981540005772	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
981540005773	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
981540005774	Coenzyme A binding pocket [chemical binding]; other site
981540005775	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
981540005776	beta-galactosidase; Region: BGL; TIGR03356
981540005777	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
981540005778	methionine cluster; other site
981540005779	active site
981540005780	phosphorylation site [posttranslational modification]
981540005781	metal binding site [ion binding]; metal-binding site
981540005782	truncated transposase IS116/IS110/IS902 family protein
981540005783	truncated transposase IS116/IS110/IS902 family protein
981540005784	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
981540005785	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
981540005786	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
981540005787	active site
981540005788	P-loop; other site
981540005789	phosphorylation site [posttranslational modification]
981540005790	HTH domain; Region: HTH_11; pfam08279
981540005791	Mga helix-turn-helix domain; Region: Mga; pfam05043
981540005792	PRD domain; Region: PRD; pfam00874
981540005793	PRD domain; Region: PRD; pfam00874
981540005794	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
981540005795	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
981540005796	active site
981540005797	phosphorylation site [posttranslational modification]
981540005798	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
981540005799	Beta-lactamase; Region: Beta-lactamase; pfam00144
981540005800	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
981540005801	amphipathic channel; other site
981540005802	Asn-Pro-Ala signature motifs; other site
981540005803	x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371
981540005804	X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; pfam09168
981540005805	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
981540005806	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
981540005807	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
981540005808	dimer interface [polypeptide binding]; other site
981540005809	phosphorylation site [posttranslational modification]
981540005810	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
981540005811	ATP binding site [chemical binding]; other site
981540005812	Mg2+ binding site [ion binding]; other site
981540005813	G-X-G motif; other site
981540005814	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
981540005815	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
981540005816	active site
981540005817	phosphorylation site [posttranslational modification]
981540005818	intermolecular recognition site; other site
981540005819	dimerization interface [polypeptide binding]; other site
981540005820	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
981540005821	DNA binding site [nucleotide binding]
981540005822	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
981540005823	PhoU domain; Region: PhoU; pfam01895
981540005824	PhoU domain; Region: PhoU; pfam01895
981540005825	phosphate transporter ATP-binding protein; Provisional; Region: PRK14240
981540005826	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
981540005827	Walker A/P-loop; other site
981540005828	ATP binding site [chemical binding]; other site
981540005829	Q-loop/lid; other site
981540005830	ABC transporter signature motif; other site
981540005831	Walker B; other site
981540005832	D-loop; other site
981540005833	H-loop/switch region; other site
981540005834	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
981540005835	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
981540005836	dimer interface [polypeptide binding]; other site
981540005837	conserved gate region; other site
981540005838	putative PBP binding loops; other site
981540005839	ABC-ATPase subunit interface; other site
981540005840	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
981540005841	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
981540005842	dimer interface [polypeptide binding]; other site
981540005843	conserved gate region; other site
981540005844	putative PBP binding loops; other site
981540005845	ABC-ATPase subunit interface; other site
981540005846	PBP superfamily domain; Region: PBP_like_2; cl17296
981540005847	PBP superfamily domain; Region: PBP_like_2; cl17296
981540005848	hypothetical protein; Validated; Region: PRK00153
981540005849	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
981540005850	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
981540005851	DNA binding residues [nucleotide binding]
981540005852	dimer interface [polypeptide binding]; other site
981540005853	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
981540005854	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
981540005855	active site
981540005856	catalytic site [active]
981540005857	substrate binding site [chemical binding]; other site
981540005858	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
981540005859	HI0933-like protein; Region: HI0933_like; pfam03486
981540005860	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
981540005861	Chromate resistance exported protein; Region: Chrome_Resist; cl01744
981540005862	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
981540005863	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
981540005864	Coenzyme A binding pocket [chemical binding]; other site
981540005865	truncated threonine aldolase
981540005866	truncated threonine aldolase
981540005867	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
981540005868	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
981540005869	Predicted membrane protein [Function unknown]; Region: COG4392
981540005870	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
981540005871	UGMP family protein; Validated; Region: PRK09604
981540005872	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
981540005873	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
981540005874	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
981540005875	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
981540005876	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
981540005877	Coenzyme A binding pocket [chemical binding]; other site
981540005878	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
981540005879	Glycoprotease family; Region: Peptidase_M22; pfam00814
981540005880	hypothetical protein; Provisional; Region: PRK13667
981540005881	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
981540005882	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
981540005883	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
981540005884	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
981540005885	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
981540005886	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
981540005887	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
981540005888	active site
981540005889	dimer interface [polypeptide binding]; other site
981540005890	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
981540005891	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
981540005892	active site
981540005893	FMN binding site [chemical binding]; other site
981540005894	substrate binding site [chemical binding]; other site
981540005895	3Fe-4S cluster binding site [ion binding]; other site
981540005896	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
981540005897	domain interface; other site
981540005898	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
981540005899	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
981540005900	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
981540005901	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
981540005902	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
981540005903	DNA binding residues [nucleotide binding]
981540005904	putative dimer interface [polypeptide binding]; other site
981540005905	Predicted membrane protein [Function unknown]; Region: COG4129
981540005906	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
981540005907	Phosphoglycerate kinase; Region: PGK; pfam00162
981540005908	substrate binding site [chemical binding]; other site
981540005909	hinge regions; other site
981540005910	ADP binding site [chemical binding]; other site
981540005911	catalytic site [active]
981540005912	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
981540005913	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
981540005914	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
981540005915	elongation factor G; Reviewed; Region: PRK00007
981540005916	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
981540005917	G1 box; other site
981540005918	putative GEF interaction site [polypeptide binding]; other site
981540005919	GTP/Mg2+ binding site [chemical binding]; other site
981540005920	Switch I region; other site
981540005921	G2 box; other site
981540005922	G3 box; other site
981540005923	Switch II region; other site
981540005924	G4 box; other site
981540005925	G5 box; other site
981540005926	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
981540005927	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
981540005928	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
981540005929	30S ribosomal protein S7; Validated; Region: PRK05302
981540005930	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
981540005931	S17 interaction site [polypeptide binding]; other site
981540005932	S8 interaction site; other site
981540005933	16S rRNA interaction site [nucleotide binding]; other site
981540005934	streptomycin interaction site [chemical binding]; other site
981540005935	23S rRNA interaction site [nucleotide binding]; other site
981540005936	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
981540005937	pur operon repressor; Provisional; Region: PRK09213
981540005938	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
981540005939	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
981540005940	active site
981540005941	Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481
981540005942	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
981540005943	generic binding surface II; other site
981540005944	generic binding surface I; other site
981540005945	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
981540005946	Zn2+ binding site [ion binding]; other site
981540005947	Mg2+ binding site [ion binding]; other site
981540005948	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
981540005949	RmuC family; Region: RmuC; pfam02646
981540005950	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
981540005951	Thiamine pyrophosphokinase; Region: TPK; cd07995
981540005952	active site
981540005953	dimerization interface [polypeptide binding]; other site
981540005954	thiamine binding site [chemical binding]; other site
981540005955	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
981540005956	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
981540005957	substrate binding site [chemical binding]; other site
981540005958	hexamer interface [polypeptide binding]; other site
981540005959	metal binding site [ion binding]; metal-binding site
981540005960	GTPase RsgA; Reviewed; Region: PRK00098
981540005961	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
981540005962	RNA binding site [nucleotide binding]; other site
981540005963	homodimer interface [polypeptide binding]; other site
981540005964	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
981540005965	GTPase/Zn-binding domain interface [polypeptide binding]; other site
981540005966	GTP/Mg2+ binding site [chemical binding]; other site
981540005967	G4 box; other site
981540005968	G1 box; other site
981540005969	Switch I region; other site
981540005970	G2 box; other site
981540005971	G3 box; other site
981540005972	Switch II region; other site
981540005973	Enterocin A Immunity; Region: EntA_Immun; pfam08951
981540005974	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
981540005975	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
981540005976	S-adenosylmethionine binding site [chemical binding]; other site
981540005977	Protein of unknown function (DUF1697); Region: DUF1697; pfam08002
981540005978	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
981540005979	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
981540005980	putative active site [active]
981540005981	putative metal binding site [ion binding]; other site
981540005982	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
981540005983	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
981540005984	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
981540005985	active site
981540005986	truncated Cna protein B-type domain-containing protein
981540005987	truncated Cna protein B-type domain-containing protein
981540005988	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
981540005989	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
981540005990	tetramer (dimer of dimers) interface [polypeptide binding]; other site
981540005991	NAD binding site [chemical binding]; other site
981540005992	dimer interface [polypeptide binding]; other site
981540005993	substrate binding site [chemical binding]; other site
981540005994	truncated CAAX amino terminal protease family protein
981540005995	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
981540005996	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
981540005997	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
981540005998	Soluble P-type ATPase [General function prediction only]; Region: COG4087
981540005999	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
981540006000	active site
981540006001	catalytic site [active]
981540006002	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
981540006003	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
981540006004	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
981540006005	Listeria-Bacteroides repeat domain (List_Bact_rpt); Region: Flg_new; pfam09479
981540006006	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
981540006007	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
981540006008	Catalytic site [active]
981540006009	truncated UbiE/COQ5 family methlytransferase
981540006010	truncated ATP-binding cassette, subfamily C, bacterial
981540006011	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
981540006012	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
981540006013	ABC-ATPase subunit  interface; other site
981540006014	dimer interface [polypeptide binding]; other site
981540006015	putative PBP binding regions; other site
981540006016	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
981540006017	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
981540006018	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
981540006019	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
981540006020	metal binding site [ion binding]; metal-binding site
981540006021	2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390
981540006022	malate dehydrogenase; Provisional; Region: PRK13529
981540006023	Malic enzyme, N-terminal domain; Region: malic; pfam00390
981540006024	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
981540006025	NAD(P) binding site [chemical binding]; other site
981540006026	Transcriptional regulator [Transcription]; Region: LysR; COG0583
981540006027	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
981540006028	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
981540006029	dimerization interface [polypeptide binding]; other site
981540006030	truncated putative glucan-binding protein D, BglB-like protein
981540006031	D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092
981540006032	DltD N-terminal region; Region: DltD_N; pfam04915
981540006033	DltD central region; Region: DltD_M; pfam04918
981540006034	DltD C-terminal region; Region: DltD_C; pfam04914
981540006035	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087
981540006036	D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091
981540006037	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
981540006038	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
981540006039	acyl-activating enzyme (AAE) consensus motif; other site
981540006040	AMP binding site [chemical binding]; other site
981540006041	D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459
981540006042	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
981540006043	truncated V-type H+-transporting ATPase subunit D
981540006044	Ribosomal protein L34; Region: Ribosomal_L34; cl00370
981540006045	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
981540006046	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
981540006047	G-X-X-G motif; other site
981540006048	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
981540006049	RxxxH motif; other site
981540006050	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
981540006051	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
981540006052	ribonuclease P; Reviewed; Region: rnpA; PRK00499
981540006053	argininosuccinate lyase; Provisional; Region: PRK00855
981540006054	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
981540006055	active sites [active]
981540006056	tetramer interface [polypeptide binding]; other site
981540006057	argininosuccinate synthase; Provisional; Region: PRK13820
981540006058	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
981540006059	ANP binding site [chemical binding]; other site
981540006060	Substrate Binding Site II [chemical binding]; other site
981540006061	Substrate Binding Site I [chemical binding]; other site
981540006062	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
981540006063	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
981540006064	putative substrate translocation pore; other site
981540006065	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
981540006066	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
981540006067	active site
981540006068	HIGH motif; other site
981540006069	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
981540006070	active site
981540006071	KMSKS motif; other site
981540006072	Tubby C 2; Region: Tub_2; cl02043
981540006073	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
981540006074	active site clefts [active]
981540006075	zinc binding site [ion binding]; other site
981540006076	dimer interface [polypeptide binding]; other site
981540006077	DNA repair protein RadA; Provisional; Region: PRK11823
981540006078	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
981540006079	Walker A motif; other site
981540006080	ATP binding site [chemical binding]; other site
981540006081	Walker B motif; other site
981540006082	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
981540006083	truncated phosphoglycerate mutase family protein
981540006084	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
981540006085	trimer interface [polypeptide binding]; other site
981540006086	active site
981540006087	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636
981540006088	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
981540006089	DNA-binding site [nucleotide binding]; DNA binding site
981540006090	RNA-binding motif; other site
981540006091	truncated phage integrase family recombinase
981540006092	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
981540006093	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
981540006094	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
981540006095	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
981540006096	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
981540006097	active site
981540006098	tetramer interface; other site
981540006099	truncated transposase
981540006100	Rhomboid family; Region: Rhomboid; pfam01694
981540006101	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
981540006102	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
981540006103	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
981540006104	M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670
981540006105	metal binding site [ion binding]; metal-binding site
981540006106	putative dimer interface [polypeptide binding]; other site
981540006107	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
981540006108	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
981540006109	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
981540006110	trimer interface [polypeptide binding]; other site
981540006111	active site
981540006112	substrate binding site [chemical binding]; other site
981540006113	CoA binding site [chemical binding]; other site
981540006114	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
981540006115	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
981540006116	active site
981540006117	dimer interface [polypeptide binding]; other site
981540006118	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
981540006119	dimer interface [polypeptide binding]; other site
981540006120	active site
981540006121	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
981540006122	nucleoside/Zn binding site; other site
981540006123	dimer interface [polypeptide binding]; other site
981540006124	catalytic motif [active]
981540006125	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
981540006126	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
981540006127	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
981540006128	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
981540006129	Protein of unknown function (DUF975); Region: DUF975; cl10504
981540006130	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
981540006131	metal binding site 2 [ion binding]; metal-binding site
981540006132	putative DNA binding helix; other site
981540006133	metal binding site 1 [ion binding]; metal-binding site
981540006134	dimer interface [polypeptide binding]; other site
981540006135	structural Zn2+ binding site [ion binding]; other site
981540006136	Phenolic acid decarboxylase (PAD); Region: PA_decarbox; pfam05870
981540006137	Predicted transcriptional regulators [Transcription]; Region: COG1695
981540006138	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
981540006139	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
981540006140	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
981540006141	DNA polymerase I; Provisional; Region: PRK05755
981540006142	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
981540006143	active site
981540006144	metal binding site 1 [ion binding]; metal-binding site
981540006145	putative 5' ssDNA interaction site; other site
981540006146	metal binding site 3; metal-binding site
981540006147	metal binding site 2 [ion binding]; metal-binding site
981540006148	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
981540006149	putative DNA binding site [nucleotide binding]; other site
981540006150	putative metal binding site [ion binding]; other site
981540006151	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
981540006152	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
981540006153	active site
981540006154	DNA binding site [nucleotide binding]
981540006155	catalytic site [active]
981540006156	Membrane transport protein; Region: Mem_trans; pfam03547
981540006157	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
981540006158	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
981540006159	TPP-binding site [chemical binding]; other site
981540006160	dimer interface [polypeptide binding]; other site
981540006161	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
981540006162	PYR/PP interface [polypeptide binding]; other site
981540006163	dimer interface [polypeptide binding]; other site
981540006164	TPP binding site [chemical binding]; other site
981540006165	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
981540006166	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
981540006167	active site
981540006168	intersubunit interactions; other site
981540006169	catalytic residue [active]
981540006170	putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709
981540006171	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
981540006172	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
981540006173	Mga helix-turn-helix domain; Region: Mga; pfam05043
981540006174	PRD domain; Region: PRD; pfam00874
981540006175	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
981540006176	active site
981540006177	P-loop; other site
981540006178	phosphorylation site [posttranslational modification]
981540006179	Phosphoenolpyruvate-dependent sugar phosphotransferase system, EIIA 2; Region: PTS_EIIA_2; pfam00359
981540006180	active site
981540006181	phosphorylation site [posttranslational modification]
981540006182	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
981540006183	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
981540006184	active site
981540006185	intersubunit interface [polypeptide binding]; other site
981540006186	catalytic residue [active]
981540006187	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
981540006188	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
981540006189	inhibitor site; inhibition site
981540006190	active site
981540006191	dimer interface [polypeptide binding]; other site
981540006192	catalytic residue [active]
981540006193	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
981540006194	putative active site [active]
981540006195	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997
981540006196	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
981540006197	active site
981540006198	P-loop; other site
981540006199	phosphorylation site [posttranslational modification]
981540006200	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
981540006201	active site
981540006202	phosphorylation site [posttranslational modification]
981540006203	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
981540006204	PRD domain; Region: PRD; pfam00874
981540006205	PRD domain; Region: PRD; pfam00874
981540006206	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
981540006207	active site
981540006208	P-loop; other site
981540006209	phosphorylation site [posttranslational modification]
981540006210	L-ribulose-5-phosphate 4-epimerase; Provisional; Region: araD; PRK13145
981540006211	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
981540006212	intersubunit interface [polypeptide binding]; other site
981540006213	active site
981540006214	Zn2+ binding site [ion binding]; other site
981540006215	putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210
981540006216	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
981540006217	AP (apurinic/apyrimidinic) site pocket; other site
981540006218	DNA interaction; other site
981540006219	Metal-binding active site; metal-binding site
981540006220	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
981540006221	active site
981540006222	dimer interface [polypeptide binding]; other site
981540006223	magnesium binding site [ion binding]; other site
981540006224	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
981540006225	active site
981540006226	phosphorylation site [posttranslational modification]
981540006227	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
981540006228	active site
981540006229	P-loop; other site
981540006230	phosphorylation site [posttranslational modification]
981540006231	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997
981540006232	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
981540006233	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
981540006234	GDP-binding site [chemical binding]; other site
981540006235	ACT binding site; other site
981540006236	IMP binding site; other site
981540006237	bifunctional glutamate--cysteine ligase/glutathione synthetase; Provisional; Region: PRK02471
981540006238	Glutamate-cysteine ligase; Region: Glu_cys_ligase; cl17352
981540006239	ATP-grasp domain; Region: ATP-grasp_4; cl17255
981540006240	Uncharacterized protein involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TelA; COG3853
981540006241	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
981540006242	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
981540006243	dimerization interface [polypeptide binding]; other site
981540006244	domain crossover interface; other site
981540006245	redox-dependent activation switch; other site
981540006246	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
981540006247	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
981540006248	FMN binding site [chemical binding]; other site
981540006249	active site
981540006250	catalytic residues [active]
981540006251	substrate binding site [chemical binding]; other site
981540006252	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
981540006253	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
981540006254	Walker A motif; other site
981540006255	ATP binding site [chemical binding]; other site
981540006256	Walker B motif; other site
981540006257	arginine finger; other site
981540006258	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
981540006259	Walker A motif; other site
981540006260	ATP binding site [chemical binding]; other site
981540006261	Walker B motif; other site
981540006262	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
981540006263	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848
981540006264	Putative small multi-drug export protein; Region: Sm_multidrug_ex; pfam06695
981540006265	elongation factor Ts; Provisional; Region: tsf; PRK09377
981540006266	UBA/TS-N domain; Region: UBA; pfam00627
981540006267	Elongation factor TS; Region: EF_TS; pfam00889
981540006268	Elongation factor TS; Region: EF_TS; pfam00889
981540006269	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
981540006270	rRNA interaction site [nucleotide binding]; other site
981540006271	S8 interaction site; other site
981540006272	putative laminin-1 binding site; other site
981540006273	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
981540006274	putative dimer interface [polypeptide binding]; other site
981540006275	catalytic triad [active]
981540006276	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
981540006277	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
981540006278	active site
981540006279	Zn binding site [ion binding]; other site
981540006280	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
981540006281	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
981540006282	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
981540006283	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
981540006284	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
981540006285	Ca binding site [ion binding]; other site
981540006286	active site
981540006287	catalytic site [active]
981540006288	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
981540006289	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
981540006290	active site turn [active]
981540006291	phosphorylation site [posttranslational modification]
981540006292	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
981540006293	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
981540006294	HPr interaction site; other site
981540006295	glycerol kinase (GK) interaction site [polypeptide binding]; other site
981540006296	active site
981540006297	phosphorylation site [posttranslational modification]
981540006298	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
981540006299	DNA-binding site [nucleotide binding]; DNA binding site
981540006300	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
981540006301	UTRA domain; Region: UTRA; pfam07702
981540006302	truncated Cna protein B-type domain-containing protein
981540006303	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
981540006304	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
981540006305	Walker A motif; other site
981540006306	ATP binding site [chemical binding]; other site
981540006307	Walker B motif; other site
981540006308	arginine finger; other site
981540006309	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
981540006310	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
981540006311	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
981540006312	FeS/SAM binding site; other site
981540006313	Predicted acetyltransferase [General function prediction only]; Region: COG3981
981540006314	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
981540006315	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
981540006316	ATP cone domain; Region: ATP-cone; pfam03477
981540006317	Class III ribonucleotide reductase; Region: RNR_III; cd01675
981540006318	effector binding site; other site
981540006319	active site
981540006320	Zn binding site [ion binding]; other site
981540006321	glycine loop; other site
981540006322	truncated predicted membrane protein
981540006323	truncated predicted membrane protein
981540006324	hypothetical protein; Provisional; Region: PRK13678
981540006325	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
981540006326	hypothetical protein; Provisional; Region: PRK05473
981540006327	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
981540006328	ArsC family; Region: ArsC; pfam03960
981540006329	putative catalytic residues [active]
981540006330	thiol/disulfide switch; other site
981540006331	recombinase A; Provisional; Region: recA; PRK09354
981540006332	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
981540006333	hexamer interface [polypeptide binding]; other site
981540006334	Walker A motif; other site
981540006335	ATP binding site [chemical binding]; other site
981540006336	Walker B motif; other site
981540006337	competence damage-inducible protein A; Provisional; Region: PRK00549
981540006338	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
981540006339	putative MPT binding site; other site
981540006340	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
981540006341	truncated major facilitator superfamily protein
981540006342	truncated signal peptide containing protein
981540006343	truncated predicted membrane protein
981540006344	truncated predicted membrane protein
981540006345	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
981540006346	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
981540006347	non-specific DNA binding site [nucleotide binding]; other site
981540006348	salt bridge; other site
981540006349	sequence-specific DNA binding site [nucleotide binding]; other site
981540006350	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
981540006351	RuvA N terminal domain; Region: RuvA_N; pfam01330
981540006352	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
981540006353	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
981540006354	ATP binding site [chemical binding]; other site
981540006355	Mg2+ binding site [ion binding]; other site
981540006356	G-X-G motif; other site
981540006357	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
981540006358	ATP binding site [chemical binding]; other site
981540006359	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
981540006360	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
981540006361	MutS domain I; Region: MutS_I; pfam01624
981540006362	MutS domain II; Region: MutS_II; pfam05188
981540006363	MutS domain III; Region: MutS_III; pfam05192
981540006364	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
981540006365	Walker A/P-loop; other site
981540006366	ATP binding site [chemical binding]; other site
981540006367	Q-loop/lid; other site
981540006368	ABC transporter signature motif; other site
981540006369	Walker B; other site
981540006370	D-loop; other site
981540006371	H-loop/switch region; other site
981540006372	Protein of unknown function (DUF964); Region: DUF964; cl01483
981540006373	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
981540006374	arginine repressor; Region: argR_whole; TIGR01529
981540006375	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
981540006376	arginyl-tRNA synthetase; Reviewed; Region: PRK12451
981540006377	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
981540006378	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
981540006379	active site
981540006380	HIGH motif; other site
981540006381	KMSK motif region; other site
981540006382	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
981540006383	tRNA binding surface [nucleotide binding]; other site
981540006384	anticodon binding site; other site
981540006385	Enterocin A Immunity; Region: EntA_Immun; pfam08951
981540006386	Predicted peptidase [General function prediction only]; Region: COG4099
981540006387	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
981540006388	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
981540006389	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
981540006390	active site turn [active]
981540006391	phosphorylation site [posttranslational modification]
981540006392	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
981540006393	Uncharacterized conserved protein [Function unknown]; Region: COG1284
981540006394	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
981540006395	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
981540006396	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
981540006397	Uncharacterized conserved protein [Function unknown]; Region: COG1284
981540006398	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
981540006399	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
981540006400	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
981540006401	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
981540006402	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
981540006403	dimer interface [polypeptide binding]; other site
981540006404	anticodon binding site; other site
981540006405	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
981540006406	homodimer interface [polypeptide binding]; other site
981540006407	motif 1; other site
981540006408	active site
981540006409	motif 2; other site
981540006410	GAD domain; Region: GAD; pfam02938
981540006411	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
981540006412	motif 3; other site
981540006413	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
981540006414	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
981540006415	dimer interface [polypeptide binding]; other site
981540006416	motif 1; other site
981540006417	active site
981540006418	motif 2; other site
981540006419	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
981540006420	anticodon binding site; other site
981540006421	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
981540006422	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
981540006423	TIR domain; Region: TIR_2; pfam13676
981540006424	MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex.   MutH...; Region: MutH_Sau3AI; cd00583
981540006425	putative DNA-binding cleft [nucleotide binding]; other site
981540006426	putative DNA clevage site; other site
981540006427	molecular lever; other site
981540006428	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
981540006429	DNA-methyltransferase (dcm); Region: dcm; TIGR00675
981540006430	cofactor binding site; other site
981540006431	DNA binding site [nucleotide binding]
981540006432	substrate interaction site [chemical binding]; other site
981540006433	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
981540006434	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
981540006435	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
981540006436	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
981540006437	Plasmid replication protein; Region: Rep_2; pfam01719
981540006438	truncated phage integrase family recombinase
981540006439	truncated phage integrase family recombinase
981540006440	Transposase; Region: DEDD_Tnp_IS110; pfam01548
981540006441	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
981540006442	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
981540006443	Predicted transcriptional regulators [Transcription]; Region: COG1695
981540006444	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
981540006445	putative DNA binding site [nucleotide binding]; other site
981540006446	putative Zn2+ binding site [ion binding]; other site
981540006447	Predicted membrane protein [Function unknown]; Region: COG4709
981540006448	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
981540006449	Predicted membrane protein [Function unknown]; Region: COG3759
981540006450	Predicted membrane protein [Function unknown]; Region: COG1511
981540006451	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
981540006452	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
981540006453	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
981540006454	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
981540006455	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
981540006456	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
981540006457	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
981540006458	RNA binding surface [nucleotide binding]; other site
981540006459	Uncharacterized protein conserved in bacteria [Function unknown]; Region: Veg; COG4466
981540006460	replicative DNA helicase; Provisional; Region: PRK05748
981540006461	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
981540006462	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
981540006463	Walker A motif; other site
981540006464	ATP binding site [chemical binding]; other site
981540006465	Walker B motif; other site
981540006466	DNA binding loops [nucleotide binding]
981540006467	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
981540006468	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
981540006469	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
981540006470	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
981540006471	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
981540006472	DHH family; Region: DHH; pfam01368
981540006473	DHHA1 domain; Region: DHHA1; pfam02272
981540006474	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
981540006475	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
981540006476	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
981540006477	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
981540006478	nudix motif; other site
981540006479	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
981540006480	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
981540006481	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
981540006482	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
981540006483	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
981540006484	putative L-serine binding site [chemical binding]; other site
981540006485	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
981540006486	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
981540006487	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
981540006488	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
981540006489	motif II; other site
981540006490	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
981540006491	N-acetyl-D-glucosamine binding site [chemical binding]; other site
981540006492	catalytic residue [active]
981540006493	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
981540006494	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
981540006495	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
981540006496	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13649
981540006497	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
981540006498	Walker A/P-loop; other site
981540006499	ATP binding site [chemical binding]; other site
981540006500	Q-loop/lid; other site
981540006501	ABC transporter signature motif; other site
981540006502	Walker B; other site
981540006503	D-loop; other site
981540006504	H-loop/switch region; other site
981540006505	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13650
981540006506	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
981540006507	Walker A/P-loop; other site
981540006508	ATP binding site [chemical binding]; other site
981540006509	Q-loop/lid; other site
981540006510	ABC transporter signature motif; other site
981540006511	Walker B; other site
981540006512	D-loop; other site
981540006513	H-loop/switch region; other site
981540006514	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
981540006515	Helix-turn-helix domain; Region: HTH_25; pfam13413
981540006516	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
981540006517	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
981540006518	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
981540006519	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
981540006520	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
981540006521	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
981540006522	sequence-specific DNA binding site [nucleotide binding]; other site
981540006523	salt bridge; other site
981540006524	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; cl10713
981540006525	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
981540006526	non-specific DNA binding site [nucleotide binding]; other site
981540006527	salt bridge; other site
981540006528	sequence-specific DNA binding site [nucleotide binding]; other site
981540006529	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
981540006530	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
981540006531	non-specific DNA binding site [nucleotide binding]; other site
981540006532	salt bridge; other site
981540006533	sequence-specific DNA binding site [nucleotide binding]; other site
981540006534	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
981540006535	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
981540006536	Int/Topo IB signature motif; other site
981540006537	S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988
981540006538	recombination protein F; Reviewed; Region: recF; PRK00064
981540006539	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
981540006540	Walker A/P-loop; other site
981540006541	ATP binding site [chemical binding]; other site
981540006542	Q-loop/lid; other site
981540006543	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
981540006544	ABC transporter signature motif; other site
981540006545	Walker B; other site
981540006546	D-loop; other site
981540006547	H-loop/switch region; other site
981540006548	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
981540006549	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
981540006550	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
981540006551	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
981540006552	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
981540006553	active site
981540006554	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
981540006555	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
981540006556	active site
981540006557	HIGH motif; other site
981540006558	dimer interface [polypeptide binding]; other site
981540006559	KMSKS motif; other site
981540006560	Uncharacterized conserved protein [Function unknown]; Region: COG1284
981540006561	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
981540006562	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
981540006563	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
981540006564	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
981540006565	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
981540006566	ABC transporter; Region: ABC_tran_2; pfam12848
981540006567	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
981540006568	Predicted membrane protein [Function unknown]; Region: COG4485
981540006569	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
981540006570	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
981540006571	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
981540006572	protein binding site [polypeptide binding]; other site
981540006573	nucleoid occlusion protein; Region: nucleoid_noc; TIGR04285
981540006574	ParB-like nuclease domain; Region: ParBc; pfam02195