-- dump date   	20140620_083853
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
189423000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
189423000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
189423000003	Walker A motif; other site
189423000004	ATP binding site [chemical binding]; other site
189423000005	Walker B motif; other site
189423000006	arginine finger; other site
189423000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
189423000008	DnaA box-binding interface [nucleotide binding]; other site
189423000009	DNA polymerase III subunit beta; Validated; Region: PRK05643
189423000010	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
189423000011	putative DNA binding surface [nucleotide binding]; other site
189423000012	dimer interface [polypeptide binding]; other site
189423000013	beta-clamp/clamp loader binding surface; other site
189423000014	beta-clamp/translesion DNA polymerase binding surface; other site
189423000015	Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864
189423000016	D5 N terminal like; Region: D5_N; smart00885
189423000017	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
189423000018	Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708
189423000019	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
189423000020	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
189423000021	Uncharacterized phage-encoded protein [Function unknown]; Region: COG3646
189423000022	Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669
189423000023	BRO family, N-terminal domain; Region: Bro-N; smart01040
189423000024	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
189423000025	sequence-specific DNA binding site [nucleotide binding]; other site
189423000026	salt bridge; other site
189423000027	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
189423000028	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
189423000029	non-specific DNA binding site [nucleotide binding]; other site
189423000030	salt bridge; other site
189423000031	sequence-specific DNA binding site [nucleotide binding]; other site
189423000032	Predicted transcriptional regulator [Transcription]; Region: COG2932
189423000033	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
189423000034	Catalytic site [active]
189423000035	DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525
189423000036	BRO family, N-terminal domain; Region: Bro-N; pfam02498
189423000037	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
189423000038	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
189423000039	Int/Topo IB signature motif; other site
189423000040	GTP-binding protein YchF; Reviewed; Region: PRK09601
189423000041	YchF GTPase; Region: YchF; cd01900
189423000042	G1 box; other site
189423000043	GTP/Mg2+ binding site [chemical binding]; other site
189423000044	Switch I region; other site
189423000045	G2 box; other site
189423000046	Switch II region; other site
189423000047	G3 box; other site
189423000048	G4 box; other site
189423000049	G5 box; other site
189423000050	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
189423000051	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
189423000052	putative active site [active]
189423000053	catalytic residue [active]
189423000054	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
189423000055	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
189423000056	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
189423000057	ATP binding site [chemical binding]; other site
189423000058	putative Mg++ binding site [ion binding]; other site
189423000059	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
189423000060	nucleotide binding region [chemical binding]; other site
189423000061	ATP-binding site [chemical binding]; other site
189423000062	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
189423000063	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
189423000064	RNA binding surface [nucleotide binding]; other site
189423000065	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
189423000066	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
189423000067	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
189423000068	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
189423000069	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
189423000070	Ligand Binding Site [chemical binding]; other site
189423000071	TilS substrate C-terminal domain; Region: TilS_C; smart00977
189423000072	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
189423000073	active site
189423000074	ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465
189423000075	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
189423000076	Walker A motif; other site
189423000077	ATP binding site [chemical binding]; other site
189423000078	Walker B motif; other site
189423000079	arginine finger; other site
189423000080	Peptidase family M41; Region: Peptidase_M41; pfam01434
189423000081	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
189423000082	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
189423000083	DDE superfamily endonuclease; Region: DDE_3; pfam13358
189423000084	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
189423000085	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
189423000086	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
189423000087	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
189423000088	GDP-binding site [chemical binding]; other site
189423000089	ACT binding site; other site
189423000090	IMP binding site; other site
189423000091	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
189423000092	active site
189423000093	catalytic residues [active]
189423000094	DNA binding site [nucleotide binding]
189423000095	Int/Topo IB signature motif; other site
189423000096	HIRAN domain; Region: HIRAN; pfam08797
189423000097	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
189423000098	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
189423000099	non-specific DNA binding site [nucleotide binding]; other site
189423000100	salt bridge; other site
189423000101	sequence-specific DNA binding site [nucleotide binding]; other site
189423000102	Predicted transcriptional regulator [Transcription]; Region: COG2932
189423000103	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
189423000104	Catalytic site [active]
189423000105	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
189423000106	non-specific DNA binding site [nucleotide binding]; other site
189423000107	salt bridge; other site
189423000108	sequence-specific DNA binding site [nucleotide binding]; other site
189423000109	Prophage antirepressor [Transcription]; Region: COG3617
189423000110	BRO family, N-terminal domain; Region: Bro-N; smart01040
189423000111	ORF6C domain; Region: ORF6C; pfam10552
189423000112	N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681
189423000113	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
189423000114	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
189423000115	Walker A motif; other site
189423000116	ATP binding site [chemical binding]; other site
189423000117	Walker B motif; other site
189423000118	arginine finger; other site
189423000119	DNA methylase; Region: N6_N4_Mtase; cl17433
189423000120	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
189423000121	Protein of unknown function (DUF1642); Region: DUF1642; pfam07852
189423000122	Protein of unknown function (DUF1372); Region: DUF1372; pfam07116
189423000123	YopX protein; Region: YopX; pfam09643
189423000124	Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753
189423000125	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
189423000126	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
189423000127	non-specific DNA binding site [nucleotide binding]; other site
189423000128	salt bridge; other site
189423000129	sequence-specific DNA binding site [nucleotide binding]; other site
189423000130	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
189423000131	INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186
189423000132	Int/Topo IB signature motif; other site
189423000133	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
189423000134	Phage Terminase; Region: Terminase_1; pfam03354
189423000135	AAA domain; Region: AAA_13; pfam13166
189423000136	Phage capsid family; Region: Phage_capsid; pfam05065
189423000137	LEM-like domain of lamina-associated polypeptide 2 (LAP2) and similar proteins; Region: LEM_like; cd12935
189423000138	Phage protein Gp19/Gp15/Gp42; Region: Phage_Gp19; pfam09355
189423000139	galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527
189423000140	Phage-related protein [Function unknown]; Region: COG5412
189423000141	Phage-related protein [Function unknown]; Region: COG4722
189423000142	Phage tail protein; Region: Sipho_tail; cl17486
189423000143	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
189423000144	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
189423000145	toxin secretion/phage lysis holin; Region: holin_tox_secr; TIGR01593
189423000146	Phage holin protein (Holin_LLH); Region: Holin_LLH; pfam09682
189423000147	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
189423000148	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
189423000149	amidase catalytic site [active]
189423000150	Zn binding residues [ion binding]; other site
189423000151	substrate binding site [chemical binding]; other site
189423000152	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
189423000153	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
189423000154	nucleoside/Zn binding site; other site
189423000155	dimer interface [polypeptide binding]; other site
189423000156	catalytic motif [active]
189423000157	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
189423000158	trimer interface [polypeptide binding]; other site
189423000159	active site
189423000160	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
189423000161	catalytic core [active]
189423000162	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
189423000163	DNA repair protein RadA; Provisional; Region: PRK11823
189423000164	Walker A motif; other site
189423000165	ATP binding site [chemical binding]; other site
189423000166	Walker B motif; other site
189423000167	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
189423000168	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
189423000169	active site clefts [active]
189423000170	zinc binding site [ion binding]; other site
189423000171	dimer interface [polypeptide binding]; other site
189423000172	Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339
189423000173	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269
189423000174	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
189423000175	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
189423000176	active site
189423000177	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
189423000178	DNA polymerase I; Provisional; Region: PRK05755
189423000179	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
189423000180	active site
189423000181	metal binding site 1 [ion binding]; metal-binding site
189423000182	putative 5' ssDNA interaction site; other site
189423000183	metal binding site 3; metal-binding site
189423000184	metal binding site 2 [ion binding]; metal-binding site
189423000185	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
189423000186	putative DNA binding site [nucleotide binding]; other site
189423000187	putative metal binding site [ion binding]; other site
189423000188	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
189423000189	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
189423000190	active site
189423000191	DNA binding site [nucleotide binding]
189423000192	catalytic site [active]
189423000193	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
189423000194	Predicted membrane protein [Function unknown]; Region: COG2855
189423000195	aromatic amino acid aminotransferase; Validated; Region: PRK07309
189423000196	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
189423000197	pyridoxal 5'-phosphate binding site [chemical binding]; other site
189423000198	homodimer interface [polypeptide binding]; other site
189423000199	catalytic residue [active]
189423000200	Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381
189423000201	Recombination protein O N terminal; Region: RecO_N; pfam11967
189423000202	Recombination protein O C terminal; Region: RecO_C; pfam02565
189423000203	putative phosphate acyltransferase; Provisional; Region: PRK05331
189423000204	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
189423000205	Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439
189423000206	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
189423000207	ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193
189423000208	putative active site [active]
189423000209	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
189423000210	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
189423000211	Walker A/P-loop; other site
189423000212	ATP binding site [chemical binding]; other site
189423000213	Q-loop/lid; other site
189423000214	ABC transporter signature motif; other site
189423000215	Walker B; other site
189423000216	D-loop; other site
189423000217	H-loop/switch region; other site
189423000218	bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000
189423000219	HlyD family secretion protein; Region: HlyD_3; pfam13437
189423000220	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
189423000221	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
189423000222	ATP binding site [chemical binding]; other site
189423000223	active site
189423000224	substrate binding site [chemical binding]; other site
189423000225	phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857
189423000226	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
189423000227	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
189423000228	dimerization interface [polypeptide binding]; other site
189423000229	ATP binding site [chemical binding]; other site
189423000230	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
189423000231	dimerization interface [polypeptide binding]; other site
189423000232	ATP binding site [chemical binding]; other site
189423000233	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
189423000234	putative active site [active]
189423000235	catalytic triad [active]
189423000236	amidophosphoribosyltransferase; Provisional; Region: PRK07272
189423000237	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
189423000238	active site
189423000239	tetramer interface [polypeptide binding]; other site
189423000240	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
189423000241	active site
189423000242	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
189423000243	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
189423000244	dimerization interface [polypeptide binding]; other site
189423000245	putative ATP binding site [chemical binding]; other site
189423000246	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
189423000247	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
189423000248	active site
189423000249	substrate binding site [chemical binding]; other site
189423000250	cosubstrate binding site; other site
189423000251	catalytic site [active]
189423000252	VanZ like family; Region: VanZ; pfam04892
189423000253	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
189423000254	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
189423000255	purine monophosphate binding site [chemical binding]; other site
189423000256	dimer interface [polypeptide binding]; other site
189423000257	putative catalytic residues [active]
189423000258	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
189423000259	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
189423000260	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
189423000261	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
189423000262	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
189423000263	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
189423000264	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
189423000265	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
189423000266	ATP-grasp domain; Region: ATP-grasp; pfam02222
189423000267	adenylosuccinate lyase; Provisional; Region: PRK07492
189423000268	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
189423000269	tetramer interface [polypeptide binding]; other site
189423000270	active site
189423000271	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
189423000272	N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525
189423000273	Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564
189423000274	active site
189423000275	Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564
189423000276	active site
189423000277	G5 domain; Region: G5; pfam07501
189423000278	G5 domain; Region: G5; pfam07501
189423000279	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
189423000280	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
189423000281	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
189423000282	DNA-binding site [nucleotide binding]; DNA binding site
189423000283	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
189423000284	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
189423000285	Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301
189423000286	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
189423000287	active site
189423000288	phosphorylation site [posttranslational modification]
189423000289	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
189423000290	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
189423000291	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
189423000292	active pocket/dimerization site; other site
189423000293	active site
189423000294	putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815
189423000295	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
189423000296	dimer interface [polypeptide binding]; other site
189423000297	active site
189423000298	AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010
189423000299	putative active site [active]
189423000300	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
189423000301	active site
189423000302	catalytic residues [active]
189423000303	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
189423000304	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
189423000305	putative metal binding site [ion binding]; other site
189423000306	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
189423000307	active site
189423000308	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846
189423000309	putative homodimer interface [polypeptide binding]; other site
189423000310	putative homotetramer interface [polypeptide binding]; other site
189423000311	putative allosteric switch controlling residues; other site
189423000312	putative metal binding site [ion binding]; other site
189423000313	putative homodimer-homodimer interface [polypeptide binding]; other site
189423000314	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
189423000315	active site residue [active]
189423000316	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
189423000317	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
189423000318	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
189423000319	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
189423000320	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
189423000321	TrkA-N domain; Region: TrkA_N; pfam02254
189423000322	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
189423000323	active site
189423000324	Fibronectin-binding repeat; Region: SSURE; pfam11966
189423000325	Fibronectin-binding repeat; Region: SSURE; pfam11966
189423000326	Fibronectin-binding repeat; Region: SSURE; pfam11966
189423000327	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
189423000328	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
189423000329	active site
189423000330	phosphorylation site [posttranslational modification]
189423000331	intermolecular recognition site; other site
189423000332	dimerization interface [polypeptide binding]; other site
189423000333	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
189423000334	DNA binding site [nucleotide binding]
189423000335	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
189423000336	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
189423000337	dimerization interface [polypeptide binding]; other site
189423000338	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
189423000339	dimer interface [polypeptide binding]; other site
189423000340	phosphorylation site [posttranslational modification]
189423000341	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
189423000342	ATP binding site [chemical binding]; other site
189423000343	Mg2+ binding site [ion binding]; other site
189423000344	G-X-G motif; other site
189423000345	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
189423000346	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
189423000347	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
189423000348	RNA binding surface [nucleotide binding]; other site
189423000349	Helix-turn-helix domain; Region: HTH_28; pfam13518
189423000350	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
189423000351	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
189423000352	dimer interface [polypeptide binding]; other site
189423000353	conserved gate region; other site
189423000354	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
189423000355	ABC-ATPase subunit interface; other site
189423000356	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
189423000357	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
189423000358	dimer interface [polypeptide binding]; other site
189423000359	conserved gate region; other site
189423000360	putative PBP binding loops; other site
189423000361	ABC-ATPase subunit interface; other site
189423000362	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
189423000363	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
189423000364	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
189423000365	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
189423000366	active site residue [active]
189423000367	Protein of unknown function (DUF3650); Region: DUF3650; pfam12368
189423000368	Domain of unknown function (DUF4299); Region: DUF4299; pfam14132
189423000369	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
189423000370	Predicted membrane protein [Function unknown]; Region: COG4709
189423000371	Predicted transcriptional regulators [Transcription]; Region: COG1695
189423000372	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
189423000373	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
189423000374	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
189423000375	putative substrate translocation pore; other site
189423000376	ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525
189423000377	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
189423000378	Ligand binding site; other site
189423000379	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
189423000380	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
189423000381	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
189423000382	NAD(P) binding site [chemical binding]; other site
189423000383	homodimer interface [polypeptide binding]; other site
189423000384	substrate binding site [chemical binding]; other site
189423000385	active site
189423000386	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
189423000387	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
189423000388	active site
189423000389	motif I; other site
189423000390	motif II; other site
189423000391	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
189423000392	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
189423000393	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
189423000394	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
189423000395	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
189423000396	putative L-serine binding site [chemical binding]; other site
189423000397	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
189423000398	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
189423000399	bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654
189423000400	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
189423000401	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
189423000402	Walker A/P-loop; other site
189423000403	ATP binding site [chemical binding]; other site
189423000404	Q-loop/lid; other site
189423000405	ABC transporter signature motif; other site
189423000406	Walker B; other site
189423000407	D-loop; other site
189423000408	H-loop/switch region; other site
189423000409	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
189423000410	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
189423000411	substrate binding pocket [chemical binding]; other site
189423000412	membrane-bound complex binding site; other site
189423000413	hinge residues; other site
189423000414	Arginosuccinate synthase; Region: Arginosuc_synth; cl17227
189423000415	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
189423000416	Transposase; Region: DDE_Tnp_ISL3; pfam01610
189423000417	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
189423000418	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
189423000419	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
189423000420	non-specific DNA binding site [nucleotide binding]; other site
189423000421	salt bridge; other site
189423000422	sequence-specific DNA binding site [nucleotide binding]; other site
189423000423	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
189423000424	putative active site [active]
189423000425	Leucine-zipper of ternary complex factor MIP1; Region: Lzipper-MIP1; pfam14389
189423000426	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
189423000427	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
189423000428	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
189423000429	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
189423000430	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
189423000431	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
189423000432	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
189423000433	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
189423000434	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
189423000435	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
189423000436	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
189423000437	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
189423000438	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688
189423000439	nudix motif; other site
189423000440	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
189423000441	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
189423000442	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
189423000443	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
189423000444	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
189423000445	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
189423000446	hypothetical protein; Provisional; Region: PRK13667
189423000447	class IIb bacteriocin, lactobin A/cerein 7B family; Region: bact_IIb_cerein; TIGR03949
189423000448	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
189423000449	Glycoprotease family; Region: Peptidase_M22; pfam00814
189423000450	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
189423000451	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
189423000452	Coenzyme A binding pocket [chemical binding]; other site
189423000453	UGMP family protein; Validated; Region: PRK09604
189423000454	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
189423000455	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
189423000456	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
189423000457	Transposase; Region: DDE_Tnp_ISL3; pfam01610
189423000458	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
189423000459	Helix-turn-helix domain; Region: HTH_38; pfam13936
189423000460	Transposase; Region: DDE_Tnp_ISL3; pfam01610
189423000461	Winged helix-turn helix; Region: HTH_33; pfam13592
189423000462	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
189423000463	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
189423000464	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
189423000465	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
189423000466	active site
189423000467	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
189423000468	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
189423000469	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
189423000470	Walker A/P-loop; other site
189423000471	ATP binding site [chemical binding]; other site
189423000472	Q-loop/lid; other site
189423000473	ABC transporter signature motif; other site
189423000474	Walker B; other site
189423000475	D-loop; other site
189423000476	H-loop/switch region; other site
189423000477	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
189423000478	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
189423000479	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
189423000480	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
189423000481	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
189423000482	non-specific DNA binding site [nucleotide binding]; other site
189423000483	salt bridge; other site
189423000484	sequence-specific DNA binding site [nucleotide binding]; other site
189423000485	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
189423000486	CAAX protease self-immunity; Region: Abi; pfam02517
189423000487	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
189423000488	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
189423000489	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
189423000490	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
189423000491	substrate binding pocket [chemical binding]; other site
189423000492	membrane-bound complex binding site; other site
189423000493	hinge residues; other site
189423000494	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
189423000495	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
189423000496	hypothetical protein; Provisional; Region: PRK06446
189423000497	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681
189423000498	metal binding site [ion binding]; metal-binding site
189423000499	dimer interface [polypeptide binding]; other site
189423000500	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
189423000501	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
189423000502	Walker A/P-loop; other site
189423000503	ATP binding site [chemical binding]; other site
189423000504	Q-loop/lid; other site
189423000505	ABC transporter signature motif; other site
189423000506	Walker B; other site
189423000507	D-loop; other site
189423000508	H-loop/switch region; other site
189423000509	NIL domain; Region: NIL; pfam09383
189423000510	ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011
189423000511	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605
189423000512	Predicted integral membrane protein [Function unknown]; Region: COG5578
189423000513	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
189423000514	HAMP domain; Region: HAMP; pfam00672
189423000515	Histidine kinase; Region: His_kinase; pfam06580
189423000516	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
189423000517	ATP binding site [chemical binding]; other site
189423000518	Mg2+ binding site [ion binding]; other site
189423000519	G-X-G motif; other site
189423000520	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
189423000521	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
189423000522	active site
189423000523	phosphorylation site [posttranslational modification]
189423000524	intermolecular recognition site; other site
189423000525	dimerization interface [polypeptide binding]; other site
189423000526	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
189423000527	flavoprotein NrdI; Provisional; Region: PRK02551
189423000528	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
189423000529	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
189423000530	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
189423000531	LytTr DNA-binding domain; Region: LytTR; smart00850
189423000532	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
189423000533	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
189423000534	sequence-specific DNA binding site [nucleotide binding]; other site
189423000535	salt bridge; other site
189423000536	transposase, degenerate
189423000537	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
189423000538	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
189423000539	ATP binding site [chemical binding]; other site
189423000540	Mg2+ binding site [ion binding]; other site
189423000541	G-X-G motif; other site
189423000542	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
189423000543	ATP binding site [chemical binding]; other site
189423000544	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
189423000545	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
189423000546	homopentamer interface [polypeptide binding]; other site
189423000547	active site
189423000548	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
189423000549	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
189423000550	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
189423000551	dimerization interface [polypeptide binding]; other site
189423000552	active site
189423000553	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
189423000554	Lumazine binding domain; Region: Lum_binding; pfam00677
189423000555	Lumazine binding domain; Region: Lum_binding; pfam00677
189423000556	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
189423000557	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
189423000558	catalytic motif [active]
189423000559	Zn binding site [ion binding]; other site
189423000560	RibD C-terminal domain; Region: RibD_C; cl17279
189423000561	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
189423000562	RuvA N terminal domain; Region: RuvA_N; pfam01330
189423000563	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
189423000564	CAAX protease self-immunity; Region: Abi; pfam02517
189423000565	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
189423000566	putative dimer interface [polypeptide binding]; other site
189423000567	catalytic triad [active]
189423000568	Protein of unknown function (DUF1129); Region: DUF1129; cl11555
189423000569	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
189423000570	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
189423000571	Cl binding site [ion binding]; other site
189423000572	oligomer interface [polypeptide binding]; other site
189423000573	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
189423000574	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
189423000575	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
189423000576	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
189423000577	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
189423000578	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
189423000579	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
189423000580	active site
189423000581	transposase, unverified frameshift
189423000582	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
189423000583	ArsC family; Region: ArsC; pfam03960
189423000584	putative catalytic residues [active]
189423000585	thiol/disulfide switch; other site
189423000586	hypothetical protein; Provisional; Region: PRK05473
189423000587	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
189423000588	hypothetical protein; Provisional; Region: PRK13678
189423000589	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
189423000590	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
189423000591	Bacterial lipoprotein; Region: DUF3642; pfam12182
189423000592	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
189423000593	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
189423000594	Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154
189423000595	putative active site [active]
189423000596	catalytic site [active]
189423000597	Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160
189423000598	putative active site [active]
189423000599	catalytic site [active]
189423000600	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
189423000601	ATP cone domain; Region: ATP-cone; pfam03477
189423000602	Class III ribonucleotide reductase; Region: RNR_III; cd01675
189423000603	effector binding site; other site
189423000604	active site
189423000605	Zn binding site [ion binding]; other site
189423000606	glycine loop; other site
189423000607	Predicted acetyltransferase [General function prediction only]; Region: COG3981
189423000608	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
189423000609	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491
189423000610	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
189423000611	FeS/SAM binding site; other site
189423000612	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
189423000613	active site
189423000614	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
189423000615	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
189423000616	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
189423000617	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
189423000618	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
189423000619	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
189423000620	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
189423000621	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
189423000622	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
189423000623	putative translocon binding site; other site
189423000624	protein-rRNA interface [nucleotide binding]; other site
189423000625	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
189423000626	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
189423000627	G-X-X-G motif; other site
189423000628	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
189423000629	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
189423000630	23S rRNA interface [nucleotide binding]; other site
189423000631	5S rRNA interface [nucleotide binding]; other site
189423000632	putative antibiotic binding site [chemical binding]; other site
189423000633	L25 interface [polypeptide binding]; other site
189423000634	L27 interface [polypeptide binding]; other site
189423000635	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
189423000636	23S rRNA interface [nucleotide binding]; other site
189423000637	putative translocon interaction site; other site
189423000638	signal recognition particle (SRP54) interaction site; other site
189423000639	L23 interface [polypeptide binding]; other site
189423000640	trigger factor interaction site; other site
189423000641	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
189423000642	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
189423000643	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
189423000644	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
189423000645	RNA binding site [nucleotide binding]; other site
189423000646	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
189423000647	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
189423000648	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
189423000649	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
189423000650	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
189423000651	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
189423000652	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
189423000653	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
189423000654	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
189423000655	5S rRNA interface [nucleotide binding]; other site
189423000656	L27 interface [polypeptide binding]; other site
189423000657	23S rRNA interface [nucleotide binding]; other site
189423000658	L5 interface [polypeptide binding]; other site
189423000659	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
189423000660	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
189423000661	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
189423000662	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
189423000663	23S rRNA binding site [nucleotide binding]; other site
189423000664	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
189423000665	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
189423000666	SecY translocase; Region: SecY; pfam00344
189423000667	adenylate kinase; Reviewed; Region: adk; PRK00279
189423000668	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
189423000669	AMP-binding site [chemical binding]; other site
189423000670	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
189423000671	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
189423000672	rRNA binding site [nucleotide binding]; other site
189423000673	predicted 30S ribosome binding site; other site
189423000674	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
189423000675	30S ribosomal protein S13; Region: bact_S13; TIGR03631
189423000676	30S ribosomal protein S11; Validated; Region: PRK05309
189423000677	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
189423000678	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
189423000679	alphaNTD homodimer interface [polypeptide binding]; other site
189423000680	alphaNTD - beta interaction site [polypeptide binding]; other site
189423000681	alphaNTD - beta' interaction site [polypeptide binding]; other site
189423000682	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
189423000683	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
189423000684	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
189423000685	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
189423000686	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
189423000687	catalytic core [active]
189423000688	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
189423000689	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
189423000690	dimer interface [polypeptide binding]; other site
189423000691	conserved gate region; other site
189423000692	putative PBP binding loops; other site
189423000693	ABC-ATPase subunit interface; other site
189423000694	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
189423000695	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
189423000696	dimer interface [polypeptide binding]; other site
189423000697	conserved gate region; other site
189423000698	ABC-ATPase subunit interface; other site
189423000699	ABC transporter, ATP-binding protein, unverified frameshift
189423000700	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
189423000701	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
189423000702	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
189423000703	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
189423000704	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
189423000705	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
189423000706	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
189423000707	DNA-binding site [nucleotide binding]; DNA binding site
189423000708	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
189423000709	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
189423000710	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
189423000711	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
189423000712	active site
189423000713	methionine cluster; other site
189423000714	phosphorylation site [posttranslational modification]
189423000715	metal binding site [ion binding]; metal-binding site
189423000716	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
189423000717	active site
189423000718	P-loop; other site
189423000719	phosphorylation site [posttranslational modification]
189423000720	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
189423000721	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
189423000722	Pyruvate-formate lyase [Energy production and conversion]; Region: PflD; COG1882
189423000723	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
189423000724	dimer interface [polypeptide binding]; other site
189423000725	active site
189423000726	glycine loop; other site
189423000727	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
189423000728	active site
189423000729	intersubunit interactions; other site
189423000730	catalytic residue [active]
189423000731	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
189423000732	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
189423000733	dimer interface [polypeptide binding]; other site
189423000734	active site
189423000735	metal binding site [ion binding]; metal-binding site
189423000736	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
189423000737	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
189423000738	HIGH motif; other site
189423000739	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
189423000740	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
189423000741	active site
189423000742	KMSKS motif; other site
189423000743	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
189423000744	tRNA binding surface [nucleotide binding]; other site
189423000745	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
189423000746	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
189423000747	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
189423000748	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
189423000749	Coenzyme A binding pocket [chemical binding]; other site
189423000750	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
189423000751	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
189423000752	Walker A motif; other site
189423000753	ATP binding site [chemical binding]; other site
189423000754	Walker B motif; other site
189423000755	arginine finger; other site
189423000756	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
189423000757	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3575
189423000758	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
189423000759	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
189423000760	catalytic residue [active]
189423000761	putative FPP diphosphate  binding site; other site
189423000762	putative FPP binding hydrophobic cleft; other site
189423000763	dimer interface [polypeptide binding]; other site
189423000764	putative IPP diphosphate binding site; other site
189423000765	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
189423000766	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
189423000767	RIP metalloprotease RseP; Region: TIGR00054
189423000768	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
189423000769	active site
189423000770	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
189423000771	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
189423000772	putative substrate binding region [chemical binding]; other site
189423000773	prolyl-tRNA synthetase; Provisional; Region: PRK09194
189423000774	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
189423000775	dimer interface [polypeptide binding]; other site
189423000776	motif 1; other site
189423000777	active site
189423000778	motif 2; other site
189423000779	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
189423000780	putative deacylase active site [active]
189423000781	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
189423000782	active site
189423000783	motif 3; other site
189423000784	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
189423000785	anticodon binding site; other site
189423000786	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
189423000787	beta-galactosidase; Region: BGL; TIGR03356
189423000788	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
189423000789	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
189423000790	glutaminase active site [active]
189423000791	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
189423000792	dimer interface [polypeptide binding]; other site
189423000793	active site
189423000794	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
189423000795	dimer interface [polypeptide binding]; other site
189423000796	active site
189423000797	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
189423000798	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
189423000799	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
189423000800	pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102
189423000801	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
189423000802	carbohydrate binding site [chemical binding]; other site
189423000803	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
189423000804	carbohydrate binding site [chemical binding]; other site
189423000805	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
189423000806	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
189423000807	Ca binding site [ion binding]; other site
189423000808	active site
189423000809	catalytic site [active]
189423000810	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
189423000811	S17 interaction site [polypeptide binding]; other site
189423000812	S8 interaction site; other site
189423000813	16S rRNA interaction site [nucleotide binding]; other site
189423000814	streptomycin interaction site [chemical binding]; other site
189423000815	23S rRNA interaction site [nucleotide binding]; other site
189423000816	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
189423000817	30S ribosomal protein S7; Validated; Region: PRK05302
189423000818	elongation factor G; Reviewed; Region: PRK00007
189423000819	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
189423000820	G1 box; other site
189423000821	putative GEF interaction site [polypeptide binding]; other site
189423000822	GTP/Mg2+ binding site [chemical binding]; other site
189423000823	Switch I region; other site
189423000824	G2 box; other site
189423000825	G3 box; other site
189423000826	Switch II region; other site
189423000827	G4 box; other site
189423000828	G5 box; other site
189423000829	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
189423000830	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
189423000831	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
189423000832	DNA polymerase III PolC; Validated; Region: polC; PRK00448
189423000833	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
189423000834	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
189423000835	generic binding surface II; other site
189423000836	generic binding surface I; other site
189423000837	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
189423000838	active site
189423000839	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
189423000840	active site
189423000841	catalytic site [active]
189423000842	substrate binding site [chemical binding]; other site
189423000843	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
189423000844	putative PHP Thumb interface [polypeptide binding]; other site
189423000845	active site
189423000846	addiction module antitoxin, RelB/DinJ family; Region: RelB_DinJ; TIGR02384
189423000847	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041
189423000848	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
189423000849	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
189423000850	Predicted membrane protein [Function unknown]; Region: COG2261
189423000851	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
189423000852	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
189423000853	RNA binding surface [nucleotide binding]; other site
189423000854	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
189423000855	active site
189423000856	uracil binding [chemical binding]; other site
189423000857	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
189423000858	trimer interface [polypeptide binding]; other site
189423000859	active site
189423000860	G bulge; other site
189423000861	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
189423000862	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
189423000863	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
189423000864	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
189423000865	active pocket/dimerization site; other site
189423000866	active site
189423000867	phosphorylation site [posttranslational modification]
189423000868	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
189423000869	active site
189423000870	phosphorylation site [posttranslational modification]
189423000871	ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422
189423000872	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
189423000873	NAD binding site [chemical binding]; other site
189423000874	substrate binding site [chemical binding]; other site
189423000875	catalytic Zn binding site [ion binding]; other site
189423000876	tetramer interface [polypeptide binding]; other site
189423000877	structural Zn binding site [ion binding]; other site
189423000878	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
189423000879	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
189423000880	active site
189423000881	motif I; other site
189423000882	motif II; other site
189423000883	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
189423000884	CAAX protease self-immunity; Region: Abi; pfam02517
189423000885	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
189423000886	dihydropteroate synthase; Region: DHPS; TIGR01496
189423000887	substrate binding pocket [chemical binding]; other site
189423000888	dimer interface [polypeptide binding]; other site
189423000889	inhibitor binding site; inhibition site
189423000890	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
189423000891	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
189423000892	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
189423000893	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
189423000894	homodecamer interface [polypeptide binding]; other site
189423000895	GTP cyclohydrolase I; Provisional; Region: PLN03044
189423000896	active site
189423000897	putative catalytic site residues [active]
189423000898	zinc binding site [ion binding]; other site
189423000899	GTP-CH-I/GFRP interaction surface; other site
189423000900	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
189423000901	homooctamer interface [polypeptide binding]; other site
189423000902	active site
189423000903	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
189423000904	catalytic center binding site [active]
189423000905	ATP binding site [chemical binding]; other site
189423000906	Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124
189423000907	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
189423000908	23S rRNA interface [nucleotide binding]; other site
189423000909	L3 interface [polypeptide binding]; other site
189423000910	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
189423000911	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
189423000912	DDE superfamily endonuclease; Region: DDE_3; pfam13358
189423000913	Uncharacterized conserved protein [Function unknown]; Region: COG1359
189423000914	6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589
189423000915	beta-galactosidase; Region: BGL; TIGR03356
189423000916	Uncharacterized conserved protein [Function unknown]; Region: COG4095
189423000917	cellobiose phosphotransferase system IIB component; Reviewed; Region: celB; PRK09590
189423000918	active site
189423000919	P-loop; other site
189423000920	phosphorylation site [posttranslational modification]
189423000921	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
189423000922	HTH domain; Region: HTH_11; pfam08279
189423000923	Mga helix-turn-helix domain; Region: Mga; pfam05043
189423000924	PRD domain; Region: PRD; pfam00874
189423000925	PRD domain; Region: PRD; pfam00874
189423000926	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
189423000927	active site
189423000928	P-loop; other site
189423000929	phosphorylation site [posttranslational modification]
189423000930	Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: PtsN; COG1762
189423000931	active site
189423000932	phosphorylation site [posttranslational modification]
189423000933	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
189423000934	methionine cluster; other site
189423000935	active site
189423000936	phosphorylation site [posttranslational modification]
189423000937	metal binding site [ion binding]; metal-binding site
189423000938	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
189423000939	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
189423000940	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
189423000941	This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595
189423000942	putative active site [active]
189423000943	putative catalytic site [active]
189423000944	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
189423000945	catalytic residues [active]
189423000946	dimer interface [polypeptide binding]; other site
189423000947	Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083
189423000948	substrate binding site [chemical binding]; other site
189423000949	catalytic residues [active]
189423000950	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
189423000951	Transposase IS200 like; Region: Y1_Tnp; cl00848
189423000952	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
189423000953	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
189423000954	active site
189423000955	intersubunit interface [polypeptide binding]; other site
189423000956	catalytic residue [active]
189423000957	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
189423000958	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
189423000959	substrate binding site [chemical binding]; other site
189423000960	ATP binding site [chemical binding]; other site
189423000961	hypothetical protein; Provisional; Region: PRK09273
189423000962	Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698
189423000963	Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408
189423000964	gluconate 5-dehydrogenase; Provisional; Region: PRK07097
189423000965	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
189423000966	NADP binding site [chemical binding]; other site
189423000967	homodimer interface [polypeptide binding]; other site
189423000968	active site
189423000969	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
189423000970	active pocket/dimerization site; other site
189423000971	active site
189423000972	phosphorylation site [posttranslational modification]
189423000973	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
189423000974	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
189423000975	active site
189423000976	phosphorylation site [posttranslational modification]
189423000977	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
189423000978	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
189423000979	Preprotein translocase subunit YajC [Intracellular trafficking and secretion]; Region: YajC; COG1862
189423000980	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
189423000981	Transcriptional regulators [Transcription]; Region: PurR; COG1609
189423000982	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
189423000983	DNA binding site [nucleotide binding]
189423000984	domain linker motif; other site
189423000985	Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283
189423000986	putative dimerization interface [polypeptide binding]; other site
189423000987	putative ligand binding site [chemical binding]; other site
189423000988	Protein of unknown function (DUF3278); Region: DUF3278; pfam11683
189423000989	Protein of unknown function (DUF3278); Region: DUF3278; pfam11683
189423000990	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
189423000991	MraW methylase family; Region: Methyltransf_5; pfam01795
189423000992	Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839
189423000993	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
189423000994	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
189423000995	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
189423000996	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573
189423000997	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573
189423000998	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
189423000999	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
189423001000	Mg++ binding site [ion binding]; other site
189423001001	putative catalytic motif [active]
189423001002	putative substrate binding site [chemical binding]; other site
189423001003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
189423001004	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
189423001005	Walker A motif; other site
189423001006	ATP binding site [chemical binding]; other site
189423001007	Walker B motif; other site
189423001008	arginine finger; other site
189423001009	UvrB/uvrC motif; Region: UVR; pfam02151
189423001010	MoxR-like ATPases [General function prediction only]; Region: COG0714
189423001011	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
189423001012	Walker A motif; other site
189423001013	ATP binding site [chemical binding]; other site
189423001014	Walker B motif; other site
189423001015	arginine finger; other site
189423001016	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
189423001017	LuxS protein involved in autoinducer AI2 synthesis [Signal transduction mechanisms]; Region: LuxS; COG1854
189423001018	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868
189423001019	hypothetical protein; Provisional; Region: PRK13663
189423001020	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
189423001021	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
189423001022	Ca binding site [ion binding]; other site
189423001023	active site
189423001024	catalytic site [active]
189423001025	Integrase core domain; Region: rve; pfam00665
189423001026	Integrase core domain; Region: rve_2; pfam13333
189423001027	HTH-like domain; Region: HTH_21; pfam13276
189423001028	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
189423001029	Helix-turn-helix domain; Region: HTH_28; pfam13518
189423001030	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
189423001031	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
189423001032	Helix-turn-helix domain; Region: HTH_28; pfam13518
189423001033	Winged helix-turn helix; Region: HTH_29; pfam13551
189423001034	Homeodomain-like domain; Region: HTH_32; pfam13565
189423001035	Integrase core domain; Region: rve; pfam00665
189423001036	DNA polymerase processivity factor; Region: DNA_PPF; pfam02916
189423001037	Transcriptional regulator [Transcription]; Region: LytR; COG1316
189423001038	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
189423001039	polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006
189423001040	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
189423001041	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
189423001042	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
189423001043	Bacterial sugar transferase; Region: Bac_transf; pfam02397
189423001044	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
189423001045	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
189423001046	Ligand binding site; other site
189423001047	metal-binding site
189423001048	LicD family; Region: LicD; pfam04991
189423001049	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
189423001050	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
189423001051	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
189423001052	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
189423001053	Probable Catalytic site; other site
189423001054	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
189423001055	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
189423001056	tetramer interface; other site
189423001057	substrate binding site; other site
189423001058	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
189423001059	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
189423001060	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
189423001061	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
189423001062	NAD binding site [chemical binding]; other site
189423001063	substrate binding site [chemical binding]; other site
189423001064	homodimer interface [polypeptide binding]; other site
189423001065	active site
189423001066	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
189423001067	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
189423001068	NADP binding site [chemical binding]; other site
189423001069	active site
189423001070	putative substrate binding site [chemical binding]; other site
189423001071	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
189423001072	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
189423001073	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
189423001074	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
189423001075	peptide binding site [polypeptide binding]; other site
189423001076	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
189423001077	Endo-alpha-N-acetylgalactosaminidase; Region: Glyco_hydro_101; pfam12905
189423001078	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
189423001079	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
189423001080	Transglycosylase; Region: Transgly; pfam00912
189423001081	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
189423001082	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
189423001083	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
189423001084	hypothetical protein; Provisional; Region: PRK13660
189423001085	cell division protein GpsB; Provisional; Region: PRK14127
189423001086	DivIVA domain; Region: DivI1A_domain; TIGR03544
189423001087	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
189423001088	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
189423001089	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
189423001090	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
189423001091	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
189423001092	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
189423001093	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
189423001094	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
189423001095	active site
189423001096	phosphorylation site [posttranslational modification]
189423001097	intermolecular recognition site; other site
189423001098	dimerization interface [polypeptide binding]; other site
189423001099	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
189423001100	DNA binding site [nucleotide binding]
189423001101	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
189423001102	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
189423001103	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
189423001104	active site
189423001105	zinc binding site [ion binding]; other site
189423001106	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
189423001107	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
189423001108	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
189423001109	Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407
189423001110	diphosphomevalonate decarboxylase; Region: PLN02407
189423001111	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
189423001112	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
189423001113	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
189423001114	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
189423001115	homotetramer interface [polypeptide binding]; other site
189423001116	FMN binding site [chemical binding]; other site
189423001117	homodimer contacts [polypeptide binding]; other site
189423001118	putative active site [active]
189423001119	putative substrate binding site [chemical binding]; other site
189423001120	Predicted membrane protein [Function unknown]; Region: COG4758
189423001121	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
189423001122	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
189423001123	Histidine kinase; Region: HisKA_3; pfam07730
189423001124	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
189423001125	ATP binding site [chemical binding]; other site
189423001126	Mg2+ binding site [ion binding]; other site
189423001127	G-X-G motif; other site
189423001128	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
189423001129	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
189423001130	active site
189423001131	phosphorylation site [posttranslational modification]
189423001132	intermolecular recognition site; other site
189423001133	dimerization interface [polypeptide binding]; other site
189423001134	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
189423001135	DNA binding residues [nucleotide binding]
189423001136	dimerization interface [polypeptide binding]; other site
189423001137	A new structural DNA glycosylase; Region: AlkD_like; cl11434
189423001138	A new structural DNA glycosylase; Region: AlkD_like; cl11434
189423001139	A new structural DNA glycosylase; Region: AlkD_like; cl11434
189423001140	choline binding protein G, unverified frameshift
189423001141	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
189423001142	putative transposase OrfB; Reviewed; Region: PHA02517
189423001143	HTH-like domain; Region: HTH_21; pfam13276
189423001144	Integrase core domain; Region: rve; pfam00665
189423001145	Integrase core domain; Region: rve_2; pfam13333
189423001146	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
189423001147	Homeodomain-like domain; Region: HTH_23; cl17451
189423001148	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
189423001149	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
189423001150	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
189423001151	active site
189423001152	P-loop; other site
189423001153	phosphorylation site [posttranslational modification]
189423001154	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
189423001155	active site
189423001156	P-loop; other site
189423001157	phosphorylation site [posttranslational modification]
189423001158	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
189423001159	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
189423001160	active site
189423001161	P-loop; other site
189423001162	phosphorylation site [posttranslational modification]
189423001163	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
189423001164	active site
189423001165	phosphorylation site [posttranslational modification]
189423001166	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
189423001167	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
189423001168	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
189423001169	putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264
189423001170	trigger factor; Provisional; Region: tig; PRK01490
189423001171	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
189423001172	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
189423001173	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
189423001174	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
189423001175	DNA binding site [nucleotide binding]
189423001176	AAA domain; Region: AAA_30; pfam13604
189423001177	Family description; Region: UvrD_C_2; pfam13538
189423001178	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
189423001179	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
189423001180	Catalytic site [active]
189423001181	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
189423001182	ribonuclease HIII; Provisional; Region: PRK00996
189423001183	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
189423001184	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
189423001185	RNA/DNA hybrid binding site [nucleotide binding]; other site
189423001186	active site
189423001187	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
189423001188	Colicin V production protein; Region: Colicin_V; pfam02674
189423001189	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
189423001190	Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: COG1193
189423001191	MutS domain III; Region: MutS_III; pfam05192
189423001192	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
189423001193	Walker A/P-loop; other site
189423001194	ATP binding site [chemical binding]; other site
189423001195	Q-loop/lid; other site
189423001196	ABC transporter signature motif; other site
189423001197	Walker B; other site
189423001198	D-loop; other site
189423001199	H-loop/switch region; other site
189423001200	Smr domain; Region: Smr; pfam01713
189423001201	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
189423001202	amino acid carrier protein; Region: agcS; TIGR00835
189423001203	Uncharacterized conserved protein [Function unknown]; Region: COG2128
189423001204	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
189423001205	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
189423001206	C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325
189423001207	gating phenylalanine in ion channel; other site
189423001208	seryl-tRNA synthetase, unverified frameshift
189423001209	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4687
189423001210	aspartate kinase; Reviewed; Region: PRK09034
189423001211	AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245
189423001212	putative catalytic residues [active]
189423001213	putative nucleotide binding site [chemical binding]; other site
189423001214	putative aspartate binding site [chemical binding]; other site
189423001215	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
189423001216	allosteric regulatory residue; other site
189423001217	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
189423001218	enoyl-CoA hydratase; Provisional; Region: PRK07260
189423001219	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
189423001220	substrate binding site [chemical binding]; other site
189423001221	oxyanion hole (OAH) forming residues; other site
189423001222	trimer interface [polypeptide binding]; other site
189423001223	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
189423001224	MarR family; Region: MarR_2; pfam12802
189423001225	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
189423001226	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
189423001227	dimer interface [polypeptide binding]; other site
189423001228	active site
189423001229	CoA binding pocket [chemical binding]; other site
189423001230	acyl carrier protein; Provisional; Region: acpP; PRK00982
189423001231	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
189423001232	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
189423001233	FMN binding site [chemical binding]; other site
189423001234	substrate binding site [chemical binding]; other site
189423001235	putative catalytic residue [active]
189423001236	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
189423001237	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
189423001238	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
189423001239	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
189423001240	NAD(P) binding site [chemical binding]; other site
189423001241	homotetramer interface [polypeptide binding]; other site
189423001242	homodimer interface [polypeptide binding]; other site
189423001243	active site
189423001244	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
189423001245	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
189423001246	dimer interface [polypeptide binding]; other site
189423001247	active site
189423001248	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
189423001249	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
189423001250	carboxyltransferase (CT) interaction site; other site
189423001251	biotinylation site [posttranslational modification]; other site
189423001252	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
189423001253	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
189423001254	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
189423001255	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
189423001256	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
189423001257	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
189423001258	Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571
189423001259	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
189423001260	acetyl-CoA carboxylase subunit alpha; Provisional; Region: PRK12319
189423001261	CAAX protease self-immunity; Region: Abi; pfam02517
189423001262	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
189423001263	Transposase; Region: DDE_Tnp_ISL3; pfam01610
189423001264	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
189423001265	Transposase; Region: DDE_Tnp_ISL3; pfam01610
189423001266	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
189423001267	putative RNA binding site [nucleotide binding]; other site
189423001268	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
189423001269	elongation factor P; Validated; Region: PRK00529
189423001270	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
189423001271	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
189423001272	RNA binding site [nucleotide binding]; other site
189423001273	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
189423001274	RNA binding site [nucleotide binding]; other site
189423001275	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
189423001276	(2R,3R)-2,3-butanediol dehydrogenase; Region: butanediol_DH_like; cd08233
189423001277	putative NAD(P) binding site [chemical binding]; other site
189423001278	catalytic Zn binding site [ion binding]; other site
189423001279	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
189423001280	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
189423001281	GatB domain; Region: GatB_Yqey; pfam02637
189423001282	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
189423001283	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
189423001284	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
189423001285	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
189423001286	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
189423001287	G1 box; other site
189423001288	putative GEF interaction site [polypeptide binding]; other site
189423001289	GTP/Mg2+ binding site [chemical binding]; other site
189423001290	Switch I region; other site
189423001291	G2 box; other site
189423001292	G3 box; other site
189423001293	Switch II region; other site
189423001294	G4 box; other site
189423001295	G5 box; other site
189423001296	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
189423001297	Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442
189423001298	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
189423001299	active site
189423001300	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
189423001301	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
189423001302	Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461
189423001303	DAK2 domain; Region: Dak2; pfam02734
189423001304	acetolactate synthase catalytic subunit; Reviewed; Region: PRK07282
189423001305	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
189423001306	PYR/PP interface [polypeptide binding]; other site
189423001307	dimer interface [polypeptide binding]; other site
189423001308	TPP binding site [chemical binding]; other site
189423001309	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
189423001310	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
189423001311	TPP-binding site [chemical binding]; other site
189423001312	dimer interface [polypeptide binding]; other site
189423001313	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
189423001314	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
189423001315	putative valine binding site [chemical binding]; other site
189423001316	dimer interface [polypeptide binding]; other site
189423001317	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
189423001318	ketol-acid reductoisomerase; Provisional; Region: PRK05479
189423001319	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
189423001320	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
189423001321	threonine dehydratase; Validated; Region: PRK08639
189423001322	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
189423001323	tetramer interface [polypeptide binding]; other site
189423001324	pyridoxal 5'-phosphate binding site [chemical binding]; other site
189423001325	catalytic residue [active]
189423001326	C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585
189423001327	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
189423001328	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
189423001329	Walker A/P-loop; other site
189423001330	ATP binding site [chemical binding]; other site
189423001331	Q-loop/lid; other site
189423001332	ABC transporter signature motif; other site
189423001333	Walker B; other site
189423001334	D-loop; other site
189423001335	H-loop/switch region; other site
189423001336	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
189423001337	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
189423001338	substrate binding pocket [chemical binding]; other site
189423001339	membrane-bound complex binding site; other site
189423001340	hinge residues; other site
189423001341	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
189423001342	dimer interface [polypeptide binding]; other site
189423001343	conserved gate region; other site
189423001344	putative PBP binding loops; other site
189423001345	ABC-ATPase subunit interface; other site
189423001346	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
189423001347	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
189423001348	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
189423001349	Transposase; Region: DEDD_Tnp_IS110; pfam01548
189423001350	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
189423001351	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
189423001352	active site
189423001353	DNA polymerase IV; Validated; Region: PRK02406
189423001354	DNA binding site [nucleotide binding]
189423001355	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
189423001356	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
189423001357	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
189423001358	Transposase; Region: DDE_Tnp_ISL3; pfam01610
189423001359	Mga helix-turn-helix domain; Region: Mga; pfam05043
189423001360	M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270
189423001361	Cna protein B-type domain; Region: Cna_B; pfam05738
189423001362	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
189423001363	metal ion-dependent adhesion site (MIDAS); other site
189423001364	Cna protein B-type domain; Region: Cna_B; pfam05738
189423001365	fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226
189423001366	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
189423001367	domain interaction interfaces [polypeptide binding]; other site
189423001368	Cna protein B-type domain; Region: Cna_B; pfam05738
189423001369	Cna protein B-type domain; Region: Cna_B; pfam05738
189423001370	Cna protein B-type domain; Region: Cna_B; pfam05738
189423001371	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
189423001372	active site
189423001373	catalytic site [active]
189423001374	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
189423001375	active site
189423001376	catalytic site [active]
189423001377	Sortase C (SrtC) or subfamily-3 sortases are membrane cysteine transpeptidases found in Gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_C_3; cd05827
189423001378	active site
189423001379	catalytic site [active]
189423001380	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
189423001381	Transposase; Region: DDE_Tnp_ISL3; pfam01610
189423001382	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
189423001383	Transcriptional regulators [Transcription]; Region: MarR; COG1846
189423001384	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
189423001385	non-specific DNA interactions [nucleotide binding]; other site
189423001386	DNA binding site [nucleotide binding]
189423001387	sequence specific DNA binding site [nucleotide binding]; other site
189423001388	putative cAMP binding site [chemical binding]; other site
189423001389	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
189423001390	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
189423001391	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
189423001392	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
189423001393	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
189423001394	methionine cluster; other site
189423001395	active site
189423001396	phosphorylation site [posttranslational modification]
189423001397	metal binding site [ion binding]; metal-binding site
189423001398	6-phospho-beta-galactosidase; Provisional; Region: PRK13511
189423001399	beta-galactosidase; Region: BGL; TIGR03356
189423001400	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
189423001401	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
189423001402	PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565
189423001403	active site
189423001404	P-loop; other site
189423001405	phosphorylation site [posttranslational modification]
189423001406	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
189423001407	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
189423001408	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
189423001409	TrkA-N domain; Region: TrkA_N; pfam02254
189423001410	TrkA-C domain; Region: TrkA_C; pfam02080
189423001411	TrkA-N domain; Region: TrkA_N; pfam02254
189423001412	TrkA-C domain; Region: TrkA_C; pfam02080
189423001413	Uncharacterized conserved protein [Function unknown]; Region: COG1912
189423001414	hypothetical protein; Provisional; Region: PRK13661
189423001415	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
189423001416	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
189423001417	Walker A/P-loop; other site
189423001418	ATP binding site [chemical binding]; other site
189423001419	Q-loop/lid; other site
189423001420	ABC transporter signature motif; other site
189423001421	Walker B; other site
189423001422	D-loop; other site
189423001423	H-loop/switch region; other site
189423001424	ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558
189423001425	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
189423001426	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
189423001427	Walker A/P-loop; other site
189423001428	ATP binding site [chemical binding]; other site
189423001429	Q-loop/lid; other site
189423001430	ABC transporter signature motif; other site
189423001431	Walker B; other site
189423001432	D-loop; other site
189423001433	H-loop/switch region; other site
189423001434	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
189423001435	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
189423001436	Predicted membrane protein [Function unknown]; Region: COG3601
189423001437	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
189423001438	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
189423001439	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
189423001440	active site
189423001441	ParB-like nuclease domain; Region: ParBc; cl02129
189423001442	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
189423001443	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
189423001444	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066
189423001445	CTP synthetase; Validated; Region: pyrG; PRK05380
189423001446	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
189423001447	Catalytic site [active]
189423001448	active site
189423001449	UTP binding site [chemical binding]; other site
189423001450	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
189423001451	active site
189423001452	putative oxyanion hole; other site
189423001453	catalytic triad [active]
189423001454	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
189423001455	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
189423001456	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
189423001457	PhoU domain; Region: PhoU; pfam01895
189423001458	PhoU domain; Region: PhoU; pfam01895
189423001459	Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724
189423001460	Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins.  The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with...; Region: GH85_ENGase; cd06547
189423001461	putative active site [active]
189423001462	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
189423001463	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
189423001464	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
189423001465	G5 domain; Region: G5; pfam07501
189423001466	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
189423001467	Phosphoglycerate kinase; Region: PGK; pfam00162
189423001468	substrate binding site [chemical binding]; other site
189423001469	hinge regions; other site
189423001470	ADP binding site [chemical binding]; other site
189423001471	catalytic site [active]
189423001472	Predicted membrane protein [Function unknown]; Region: COG4129
189423001473	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
189423001474	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
189423001475	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
189423001476	DNA binding residues [nucleotide binding]
189423001477	putative dimer interface [polypeptide binding]; other site
189423001478	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
189423001479	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
189423001480	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
189423001481	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
189423001482	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
189423001483	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
189423001484	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
189423001485	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
189423001486	VanD integrase, IntD, and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases including those similar to IntD, a putative integrase-like protein, a component...; Region: INT_VanD; cd01196
189423001487	Int/Topo IB signature motif; other site
189423001488	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
189423001489	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
189423001490	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
189423001491	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
189423001492	HsdM N-terminal domain; Region: HsdM_N; pfam12161
189423001493	Methyltransferase domain; Region: Methyltransf_26; pfam13659
189423001494	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
189423001495	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
189423001496	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
189423001497	ATP binding site [chemical binding]; other site
189423001498	putative Mg++ binding site [ion binding]; other site
189423001499	Protein of unknown function (DUF2812); Region: DUF2812; pfam11193
189423001500	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
189423001501	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
189423001502	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
189423001503	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
189423001504	dimer interface [polypeptide binding]; other site
189423001505	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
189423001506	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
189423001507	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
189423001508	nucleotide binding site [chemical binding]; other site
189423001509	NEF interaction site [polypeptide binding]; other site
189423001510	SBD interface [polypeptide binding]; other site
189423001511	chaperone protein DnaJ; Provisional; Region: PRK14276
189423001512	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
189423001513	HSP70 interaction site [polypeptide binding]; other site
189423001514	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
189423001515	substrate binding site [polypeptide binding]; other site
189423001516	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
189423001517	Zn binding sites [ion binding]; other site
189423001518	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
189423001519	substrate binding site [polypeptide binding]; other site
189423001520	dimer interface [polypeptide binding]; other site
189423001521	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
189423001522	HIT family signature motif; other site
189423001523	catalytic residue [active]
189423001524	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
189423001525	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
189423001526	Walker A/P-loop; other site
189423001527	ATP binding site [chemical binding]; other site
189423001528	Q-loop/lid; other site
189423001529	ABC transporter signature motif; other site
189423001530	Walker B; other site
189423001531	D-loop; other site
189423001532	H-loop/switch region; other site
189423001533	Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542
189423001534	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
189423001535	LytTr DNA-binding domain; Region: LytTR; pfam04397
189423001536	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
189423001537	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
189423001538	active site
189423001539	phosphorylation site [posttranslational modification]
189423001540	intermolecular recognition site; other site
189423001541	dimerization interface [polypeptide binding]; other site
189423001542	LytTr DNA-binding domain; Region: LytTR; pfam04397
189423001543	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
189423001544	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
189423001545	ATP binding site [chemical binding]; other site
189423001546	Mg2+ binding site [ion binding]; other site
189423001547	G-X-G motif; other site
189423001548	COMC family; Region: ComC; pfam03047
189423001549	bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000
189423001550	HlyD family secretion protein; Region: HlyD_3; pfam13437
189423001551	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
189423001552	ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193
189423001553	putative active site [active]
189423001554	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
189423001555	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
189423001556	Walker A/P-loop; other site
189423001557	ATP binding site [chemical binding]; other site
189423001558	Q-loop/lid; other site
189423001559	ABC transporter signature motif; other site
189423001560	Walker B; other site
189423001561	D-loop; other site
189423001562	H-loop/switch region; other site
189423001563	Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439
189423001564	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
189423001565	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
189423001566	CAAX protease self-immunity; Region: Abi; pfam02517
189423001567	CAAX protease self-immunity; Region: Abi; pfam02517
189423001568	Phosphotransferase enzyme family; Region: APH; pfam01636
189423001569	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
189423001570	substrate binding site [chemical binding]; other site
189423001571	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
189423001572	S-adenosylmethionine binding site [chemical binding]; other site
189423001573	ribosome maturation protein RimP; Reviewed; Region: PRK00092
189423001574	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
189423001575	putative oligomer interface [polypeptide binding]; other site
189423001576	putative RNA binding site [nucleotide binding]; other site
189423001577	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
189423001578	NusA N-terminal domain; Region: NusA_N; pfam08529
189423001579	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
189423001580	RNA binding site [nucleotide binding]; other site
189423001581	homodimer interface [polypeptide binding]; other site
189423001582	NusA-like KH domain; Region: KH_5; pfam13184
189423001583	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
189423001584	G-X-X-G motif; other site
189423001585	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
189423001586	putative RNA binding cleft [nucleotide binding]; other site
189423001587	hypothetical protein; Provisional; Region: PRK07283
189423001588	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
189423001589	translation initiation factor IF-2; Region: IF-2; TIGR00487
189423001590	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
189423001591	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
189423001592	G1 box; other site
189423001593	putative GEF interaction site [polypeptide binding]; other site
189423001594	GTP/Mg2+ binding site [chemical binding]; other site
189423001595	Switch I region; other site
189423001596	G2 box; other site
189423001597	G3 box; other site
189423001598	Switch II region; other site
189423001599	G4 box; other site
189423001600	G5 box; other site
189423001601	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
189423001602	Translation-initiation factor 2; Region: IF-2; pfam11987
189423001603	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
189423001604	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
189423001605	Domain of unknown function (DUF1858); Region: DUF1858; pfam08984
189423001606	Uncharacterized conserved protein [Function unknown]; Region: COG2461
189423001607	Family of unknown function (DUF438); Region: DUF438; pfam04282
189423001608	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
189423001609	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
189423001610	putative active site [active]
189423001611	heme pocket [chemical binding]; other site
189423001612	Domain of unknown function (DUF1912); Region: DUF1912; pfam08930
189423001613	hypothetical protein; Provisional; Region: PRK07758
189423001614	Flavin Reductases; Region: FlaRed; cl00801
189423001615	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
189423001616	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
189423001617	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
189423001618	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
189423001619	active site
189423001620	HIGH motif; other site
189423001621	nucleotide binding site [chemical binding]; other site
189423001622	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
189423001623	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
189423001624	active site
189423001625	KMSKS motif; other site
189423001626	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
189423001627	tRNA binding surface [nucleotide binding]; other site
189423001628	anticodon binding site; other site
189423001629	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
189423001630	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
189423001631	Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184
189423001632	Fic/DOC family; Region: Fic; pfam02661
189423001633	Integrase core domain; Region: rve; pfam00665
189423001634	Integrase core domain; Region: rve_2; pfam13333
189423001635	Integrase core domain; Region: rve; pfam00665
189423001636	HTH-like domain; Region: HTH_21; pfam13276
189423001637	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
189423001638	Helix-turn-helix domain; Region: HTH_28; pfam13518
189423001639	potential frameshift: common BLAST hit: gi|289167267|ref|YP_003445534.1| DNA or RNA helicases of superfamily II
189423001640	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4951
189423001641	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
189423001642	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
189423001643	putative Mg++ binding site [ion binding]; other site
189423001644	nucleotide binding region [chemical binding]; other site
189423001645	helicase superfamily c-terminal domain; Region: HELICc; smart00490
189423001646	ATP-binding site [chemical binding]; other site
189423001647	C-terminal putative phospholipase D-like domain of uncharacterized prokaryotic HKD family nucleases fused to DEAD/DEAH box helicases; Region: PLDc_C_DEXD_like; cd09126
189423001648	transcriptional antiterminator BglG; Provisional; Region: PRK09772
189423001649	CAT RNA binding domain; Region: CAT_RBD; smart01061
189423001650	PRD domain; Region: PRD; pfam00874
189423001651	PRD domain; Region: PRD; pfam00874
189423001652	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
189423001653	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
189423001654	active site turn [active]
189423001655	phosphorylation site [posttranslational modification]
189423001656	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
189423001657	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
189423001658	HPr interaction site; other site
189423001659	glycerol kinase (GK) interaction site [polypeptide binding]; other site
189423001660	active site
189423001661	phosphorylation site [posttranslational modification]
189423001662	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
189423001663	beta-galactosidase; Region: BGL; TIGR03356
189423001664	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
189423001665	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
189423001666	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
189423001667	dimer interface [polypeptide binding]; other site
189423001668	motif 1; other site
189423001669	active site
189423001670	motif 2; other site
189423001671	motif 3; other site
189423001672	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
189423001673	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
189423001674	Coenzyme A binding pocket [chemical binding]; other site
189423001675	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
189423001676	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
189423001677	putative tRNA-binding site [nucleotide binding]; other site
189423001678	B3/4 domain; Region: B3_4; pfam03483
189423001679	tRNA synthetase B5 domain; Region: B5; smart00874
189423001680	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
189423001681	dimer interface [polypeptide binding]; other site
189423001682	motif 1; other site
189423001683	motif 3; other site
189423001684	motif 2; other site
189423001685	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
189423001686	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
189423001687	putative catalytic site [active]
189423001688	putative metal binding site [ion binding]; other site
189423001689	putative phosphate binding site [ion binding]; other site
189423001690	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
189423001691	Helix-turn-helix domain; Region: HTH_38; pfam13936
189423001692	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
189423001693	non-specific DNA binding site [nucleotide binding]; other site
189423001694	salt bridge; other site
189423001695	sequence-specific DNA binding site [nucleotide binding]; other site
189423001696	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
189423001697	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
189423001698	THF binding site; other site
189423001699	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
189423001700	substrate binding site [chemical binding]; other site
189423001701	THF binding site; other site
189423001702	zinc-binding site [ion binding]; other site
189423001703	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
189423001704	FAD binding site [chemical binding]; other site
189423001705	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
189423001706	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
189423001707	RNase E interface [polypeptide binding]; other site
189423001708	trimer interface [polypeptide binding]; other site
189423001709	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
189423001710	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
189423001711	RNase E interface [polypeptide binding]; other site
189423001712	trimer interface [polypeptide binding]; other site
189423001713	active site
189423001714	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
189423001715	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
189423001716	RNA binding site [nucleotide binding]; other site
189423001717	domain interface; other site
189423001718	serine O-acetyltransferase; Region: cysE; TIGR01172
189423001719	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
189423001720	trimer interface [polypeptide binding]; other site
189423001721	active site
189423001722	substrate binding site [chemical binding]; other site
189423001723	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
189423001724	Coenzyme A binding pocket [chemical binding]; other site
189423001725	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
189423001726	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
189423001727	Coenzyme A binding pocket [chemical binding]; other site
189423001728	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
189423001729	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
189423001730	active site
189423001731	HIGH motif; other site
189423001732	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
189423001733	KMSKS motif; other site
189423001734	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
189423001735	tRNA binding surface [nucleotide binding]; other site
189423001736	anticodon binding site; other site
189423001737	Ribonuclease III family protein [Replication, recombination, and    repair]; Region: COG1939
189423001738	active site
189423001739	metal binding site [ion binding]; metal-binding site
189423001740	dimerization interface [polypeptide binding]; other site
189423001741	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
189423001742	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
189423001743	hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264
189423001744	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
189423001745	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
189423001746	FtsX-like permease family; Region: FtsX; pfam02687
189423001747	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
189423001748	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
189423001749	Walker A/P-loop; other site
189423001750	ATP binding site [chemical binding]; other site
189423001751	Q-loop/lid; other site
189423001752	ABC transporter signature motif; other site
189423001753	Walker B; other site
189423001754	D-loop; other site
189423001755	H-loop/switch region; other site
189423001756	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
189423001757	FtsX-like permease family; Region: FtsX; pfam02687
189423001758	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
189423001759	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
189423001760	active site
189423001761	phosphorylation site [posttranslational modification]
189423001762	intermolecular recognition site; other site
189423001763	dimerization interface [polypeptide binding]; other site
189423001764	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
189423001765	DNA binding site [nucleotide binding]
189423001766	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
189423001767	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
189423001768	dimerization interface [polypeptide binding]; other site
189423001769	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
189423001770	dimer interface [polypeptide binding]; other site
189423001771	phosphorylation site [posttranslational modification]
189423001772	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
189423001773	ATP binding site [chemical binding]; other site
189423001774	Mg2+ binding site [ion binding]; other site
189423001775	G-X-G motif; other site
189423001776	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
189423001777	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
189423001778	intersubunit interface [polypeptide binding]; other site
189423001779	active site
189423001780	zinc binding site [ion binding]; other site
189423001781	Na+ binding site [ion binding]; other site
189423001782	Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097
189423001783	Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794
189423001784	NAD(P) binding domain of  ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198
189423001785	FAD binding pocket [chemical binding]; other site
189423001786	FAD binding motif [chemical binding]; other site
189423001787	phosphate binding motif [ion binding]; other site
189423001788	beta-alpha-beta structure motif; other site
189423001789	NAD binding pocket [chemical binding]; other site
189423001790	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
189423001791	dimer interface [polypeptide binding]; other site
189423001792	conserved gate region; other site
189423001793	putative PBP binding loops; other site
189423001794	ABC-ATPase subunit interface; other site
189423001795	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
189423001796	dimer interface [polypeptide binding]; other site
189423001797	conserved gate region; other site
189423001798	putative PBP binding loops; other site
189423001799	ABC-ATPase subunit interface; other site
189423001800	bifunctional adhesin/ABC transporter aspartate/glutamate-binding protein; Reviewed; Region: PRK11917
189423001801	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
189423001802	substrate binding pocket [chemical binding]; other site
189423001803	membrane-bound complex binding site; other site
189423001804	hinge residues; other site
189423001805	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
189423001806	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
189423001807	Walker A/P-loop; other site
189423001808	ATP binding site [chemical binding]; other site
189423001809	Q-loop/lid; other site
189423001810	ABC transporter signature motif; other site
189423001811	Walker B; other site
189423001812	D-loop; other site
189423001813	H-loop/switch region; other site
189423001814	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
189423001815	DHH family; Region: DHH; pfam01368
189423001816	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199
189423001817	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
189423001818	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
189423001819	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
189423001820	Predicted esterase [General function prediction only]; Region: COG0627
189423001821	S-formylglutathione hydrolase; Region: PLN02442
189423001822	Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348
189423001823	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
189423001824	FemAB family; Region: FemAB; pfam02388
189423001825	Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268
189423001826	active site
189423001827	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
189423001828	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
189423001829	GIY-YIG motif/motif A; other site
189423001830	active site
189423001831	catalytic site [active]
189423001832	putative DNA binding site [nucleotide binding]; other site
189423001833	metal binding site [ion binding]; metal-binding site
189423001834	UvrB/uvrC motif; Region: UVR; pfam02151
189423001835	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
189423001836	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
189423001837	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
189423001838	active site
189423001839	metal binding site [ion binding]; metal-binding site
189423001840	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
189423001841	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
189423001842	substrate binding pocket [chemical binding]; other site
189423001843	membrane-bound complex binding site; other site
189423001844	hinge residues; other site
189423001845	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
189423001846	dimer interface [polypeptide binding]; other site
189423001847	FMN binding site [chemical binding]; other site
189423001848	dipeptidase PepV; Reviewed; Region: PRK07318
189423001849	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
189423001850	active site
189423001851	metal binding site [ion binding]; metal-binding site
189423001852	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
189423001853	putative uracil binding site [chemical binding]; other site
189423001854	putative active site [active]
189423001855	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
189423001856	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
189423001857	active site residue [active]
189423001858	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
189423001859	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
189423001860	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
189423001861	putative oligomer interface [polypeptide binding]; other site
189423001862	putative active site [active]
189423001863	metal binding site [ion binding]; metal-binding site
189423001864	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
189423001865	nucleotide binding site/active site [active]
189423001866	HIT family signature motif; other site
189423001867	catalytic residue [active]
189423001868	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
189423001869	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
189423001870	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
189423001871	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
189423001872	23S rRNA interface [nucleotide binding]; other site
189423001873	L7/L12 interface [polypeptide binding]; other site
189423001874	putative thiostrepton binding site; other site
189423001875	L25 interface [polypeptide binding]; other site
189423001876	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
189423001877	mRNA/rRNA interface [nucleotide binding]; other site
189423001878	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
189423001879	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
189423001880	Walker A/P-loop; other site
189423001881	ATP binding site [chemical binding]; other site
189423001882	Q-loop/lid; other site
189423001883	ABC transporter signature motif; other site
189423001884	Walker B; other site
189423001885	D-loop; other site
189423001886	H-loop/switch region; other site
189423001887	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
189423001888	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
189423001889	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG3694
189423001890	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
189423001891	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
189423001892	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
189423001893	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
189423001894	putative active site [active]
189423001895	catalytic triad [active]
189423001896	PA_2: Protease-associated (PA) domain subgroup 2. A subgroup of PA-domain containing proteins. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is...; Region: PA_2; cd04819
189423001897	PA/protease or protease-like domain interface [polypeptide binding]; other site
189423001898	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
189423001899	catalytic residues [active]
189423001900	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
189423001901	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
189423001902	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
189423001903	active site
189423001904	phosphorylation site [posttranslational modification]
189423001905	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
189423001906	active site
189423001907	P-loop; other site
189423001908	phosphorylation site [posttranslational modification]
189423001909	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
189423001910	PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611
189423001911	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
189423001912	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
189423001913	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
189423001914	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
189423001915	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
189423001916	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
189423001917	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
189423001918	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
189423001919	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
189423001920	G5 domain; Region: G5; pfam07501
189423001921	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
189423001922	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
189423001923	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
189423001924	Protein of unknown function (DUF3397); Region: DUF3397; pfam11877
189423001925	radical SAM superfamily protein, degenerate
189423001926	Putative rRNA methylase; Region: rRNA_methylase; pfam06962
189423001927	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
189423001928	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
189423001929	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
189423001930	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
189423001931	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
189423001932	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
189423001933	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
189423001934	catalytic residues [active]
189423001935	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
189423001936	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
189423001937	SelR domain; Region: SelR; pfam01641
189423001938	Response regulator receiver domain; Region: Response_reg; pfam00072
189423001939	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
189423001940	active site
189423001941	phosphorylation site [posttranslational modification]
189423001942	intermolecular recognition site; other site
189423001943	dimerization interface [polypeptide binding]; other site
189423001944	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
189423001945	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
189423001946	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
189423001947	Cache domain; Region: Cache_1; pfam02743
189423001948	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
189423001949	dimerization interface [polypeptide binding]; other site
189423001950	Histidine kinase; Region: His_kinase; pfam06580
189423001951	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
189423001952	ATP binding site [chemical binding]; other site
189423001953	Mg2+ binding site [ion binding]; other site
189423001954	G-X-G motif; other site
189423001955	hypothetical protein; Provisional; Region: PRK13690
189423001956	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
189423001957	Protein of unknown function (DUF2497); Region: DUF2497; cl11534
189423001958	M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342
189423001959	M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580
189423001960	aminodeoxychorismate synthase; Provisional; Region: PRK07508
189423001961	aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553
189423001962	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
189423001963	substrate-cofactor binding pocket; other site
189423001964	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
189423001965	pyridoxal 5'-phosphate binding site [chemical binding]; other site
189423001966	catalytic residue [active]
189423001967	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
189423001968	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
189423001969	Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553
189423001970	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
189423001971	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
189423001972	nucleotide binding site [chemical binding]; other site
189423001973	thymidylate synthase; Reviewed; Region: thyA; PRK01827
189423001974	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
189423001975	dimerization interface [polypeptide binding]; other site
189423001976	active site
189423001977	Protein of unknown function (DUF3042); Region: DUF3042; pfam11240
189423001978	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
189423001979	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
189423001980	GTPases [General function prediction only]; Region: HflX; COG2262
189423001981	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
189423001982	HflX GTPase family; Region: HflX; cd01878
189423001983	G1 box; other site
189423001984	GTP/Mg2+ binding site [chemical binding]; other site
189423001985	Switch I region; other site
189423001986	G2 box; other site
189423001987	G3 box; other site
189423001988	Switch II region; other site
189423001989	G4 box; other site
189423001990	G5 box; other site
189423001991	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
189423001992	ribonuclease Z; Region: RNase_Z; TIGR02651
189423001993	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
189423001994	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
189423001995	NAD(P) binding site [chemical binding]; other site
189423001996	active site
189423001997	Transcriptional regulator [Transcription]; Region: LysR; COG0583
189423001998	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
189423001999	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
189423002000	dimerization interface [polypeptide binding]; other site
189423002001	Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014
189423002002	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
189423002003	active site residue [active]
189423002004	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
189423002005	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
189423002006	RNA binding surface [nucleotide binding]; other site
189423002007	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
189423002008	active site
189423002009	uracil binding [chemical binding]; other site
189423002010	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
189423002011	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
189423002012	G1 box; other site
189423002013	putative GEF interaction site [polypeptide binding]; other site
189423002014	GTP/Mg2+ binding site [chemical binding]; other site
189423002015	Switch I region; other site
189423002016	G2 box; other site
189423002017	G3 box; other site
189423002018	Switch II region; other site
189423002019	G4 box; other site
189423002020	G5 box; other site
189423002021	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
189423002022	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
189423002023	Protein of unknown function (DUF3165); Region: DUF3165; pfam11364
189423002024	Bacteriocin (Lactococcin_972); Region: Lactococcin_972; pfam09683
189423002025	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652
189423002026	Protein of unknown function (DUF1430); Region: DUF1430; pfam07242
189423002027	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
189423002028	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
189423002029	Walker A/P-loop; other site
189423002030	ATP binding site [chemical binding]; other site
189423002031	Q-loop/lid; other site
189423002032	ABC transporter signature motif; other site
189423002033	Walker B; other site
189423002034	D-loop; other site
189423002035	H-loop/switch region; other site
189423002036	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
189423002037	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
189423002038	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
189423002039	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
189423002040	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
189423002041	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
189423002042	homodimer interface [polypeptide binding]; other site
189423002043	active site
189423002044	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
189423002045	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
189423002046	Cell division protein FtsQ; Region: FtsQ; pfam03799
189423002047	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
189423002048	active site
189423002049	dimer interface [polypeptide binding]; other site
189423002050	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
189423002051	active site
189423002052	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
189423002053	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
189423002054	Walker A/P-loop; other site
189423002055	ATP binding site [chemical binding]; other site
189423002056	Q-loop/lid; other site
189423002057	ABC transporter signature motif; other site
189423002058	Walker B; other site
189423002059	D-loop; other site
189423002060	H-loop/switch region; other site
189423002061	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
189423002062	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
189423002063	substrate binding pocket [chemical binding]; other site
189423002064	membrane-bound complex binding site; other site
189423002065	hinge residues; other site
189423002066	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
189423002067	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
189423002068	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
189423002069	Q-loop/lid; other site
189423002070	ABC transporter signature motif; other site
189423002071	Walker B; other site
189423002072	D-loop; other site
189423002073	H-loop/switch region; other site
189423002074	potential frameshift: common BLAST hit: gi|225854221|ref|YP_002735733.1| ABC transporter membrane-spanning permease - glutamine transport
189423002075	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
189423002076	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
189423002077	dimer interface [polypeptide binding]; other site
189423002078	conserved gate region; other site
189423002079	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
189423002080	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
189423002081	dimer interface [polypeptide binding]; other site
189423002082	conserved gate region; other site
189423002083	putative PBP binding loops; other site
189423002084	ABC-ATPase subunit interface; other site
189423002085	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
189423002086	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
189423002087	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
189423002088	dimer interface [polypeptide binding]; other site
189423002089	putative anticodon binding site; other site
189423002090	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
189423002091	motif 1; other site
189423002092	active site
189423002093	motif 2; other site
189423002094	motif 3; other site
189423002095	L-lactate oxidase; Region: L_lactate_ox; TIGR02708
189423002096	L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2.  This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737
189423002097	teramer interface [polypeptide binding]; other site
189423002098	active site
189423002099	FMN binding site [chemical binding]; other site
189423002100	catalytic residues [active]
189423002101	Putative transcription activator [Transcription]; Region: TenA; COG0819
189423002102	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
189423002103	substrate binding site [chemical binding]; other site
189423002104	multimerization interface [polypeptide binding]; other site
189423002105	ATP binding site [chemical binding]; other site
189423002106	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
189423002107	thiamine phosphate binding site [chemical binding]; other site
189423002108	active site
189423002109	pyrophosphate binding site [ion binding]; other site
189423002110	ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721
189423002111	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
189423002112	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
189423002113	Walker A/P-loop; other site
189423002114	ATP binding site [chemical binding]; other site
189423002115	Q-loop/lid; other site
189423002116	ABC transporter signature motif; other site
189423002117	Walker B; other site
189423002118	D-loop; other site
189423002119	H-loop/switch region; other site
189423002120	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
189423002121	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
189423002122	Walker A/P-loop; other site
189423002123	ATP binding site [chemical binding]; other site
189423002124	Q-loop/lid; other site
189423002125	ABC transporter signature motif; other site
189423002126	Walker B; other site
189423002127	D-loop; other site
189423002128	H-loop/switch region; other site
189423002129	Putative transcription activator [Transcription]; Region: TenA; COG0819
189423002130	Predicted membrane protein [Function unknown]; Region: COG4732
189423002131	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
189423002132	substrate binding site [chemical binding]; other site
189423002133	multimerization interface [polypeptide binding]; other site
189423002134	ATP binding site [chemical binding]; other site
189423002135	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
189423002136	thiamine phosphate binding site [chemical binding]; other site
189423002137	active site
189423002138	pyrophosphate binding site [ion binding]; other site
189423002139	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
189423002140	dimer interface [polypeptide binding]; other site
189423002141	substrate binding site [chemical binding]; other site
189423002142	ATP binding site [chemical binding]; other site
189423002143	Predicted transcriptional regulator [Transcription]; Region: COG3682
189423002144	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
189423002145	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
189423002146	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
189423002147	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
189423002148	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
189423002149	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
189423002150	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
189423002151	pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720
189423002152	PYR/PP interface [polypeptide binding]; other site
189423002153	dimer interface [polypeptide binding]; other site
189423002154	tetramer interface [polypeptide binding]; other site
189423002155	TPP binding site [chemical binding]; other site
189423002156	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
189423002157	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
189423002158	TPP-binding site [chemical binding]; other site
189423002159	potential frameshift: common BLAST hit: gi|298502517|ref|YP_003724457.1| glyoxalase family protein
189423002160	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
189423002161	DDE superfamily endonuclease; Region: DDE_3; pfam13358
189423002162	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
189423002163	Winged helix-turn helix; Region: HTH_33; pfam13592
189423002164	Homeodomain-like domain; Region: HTH_23; pfam13384
189423002165	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
189423002166	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
189423002167	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
189423002168	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
189423002169	putative substrate binding site 2 [chemical binding]; other site
189423002170	putative substrate binding site 1 [chemical binding]; other site
189423002171	Na binding site 1 [ion binding]; other site
189423002172	Na2 binding site [ion binding]; other site
189423002173	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
189423002174	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
189423002175	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
189423002176	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
189423002177	3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706
189423002178	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
189423002179	Domain of unknown function DUF20; Region: UPF0118; pfam01594
189423002180	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
189423002181	TPR motif; other site
189423002182	binding surface
189423002183	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
189423002184	binding surface
189423002185	TPR motif; other site
189423002186	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
189423002187	dimer interface [polypeptide binding]; other site
189423002188	conserved gate region; other site
189423002189	putative PBP binding loops; other site
189423002190	ABC-ATPase subunit interface; other site
189423002191	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
189423002192	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
189423002193	Walker A/P-loop; other site
189423002194	ATP binding site [chemical binding]; other site
189423002195	Q-loop/lid; other site
189423002196	ABC transporter signature motif; other site
189423002197	Walker B; other site
189423002198	D-loop; other site
189423002199	H-loop/switch region; other site
189423002200	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
189423002201	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
189423002202	substrate binding pocket [chemical binding]; other site
189423002203	membrane-bound complex binding site; other site
189423002204	hinge residues; other site
189423002205	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
189423002206	catalytic residues [active]
189423002207	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
189423002208	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
189423002209	active site
189423002210	substrate binding site [chemical binding]; other site
189423002211	metal binding site [ion binding]; metal-binding site
189423002212	Helix-turn-helix domain; Region: HTH_28; pfam13518
189423002213	Transposase; Region: HTH_Tnp_IS630; pfam01710
189423002214	DDE superfamily endonuclease; Region: DDE_3; pfam13358
189423002215	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
189423002216	MucBP domain; Region: MucBP; pfam06458
189423002217	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
189423002218	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
189423002219	amphipathic channel; other site
189423002220	Asn-Pro-Ala signature motifs; other site
189423002221	elongation factor Tu; Reviewed; Region: PRK00049
189423002222	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
189423002223	G1 box; other site
189423002224	GEF interaction site [polypeptide binding]; other site
189423002225	GTP/Mg2+ binding site [chemical binding]; other site
189423002226	Switch I region; other site
189423002227	G2 box; other site
189423002228	G3 box; other site
189423002229	Switch II region; other site
189423002230	G4 box; other site
189423002231	G5 box; other site
189423002232	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
189423002233	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
189423002234	Antibiotic Binding Site [chemical binding]; other site
189423002235	Homeodomain-like domain; Region: HTH_23; pfam13384
189423002236	Winged helix-turn helix; Region: HTH_29; pfam13551
189423002237	Winged helix-turn helix; Region: HTH_33; pfam13592
189423002238	DDE superfamily endonuclease; Region: DDE_3; pfam13358
189423002239	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
189423002240	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
189423002241	DEAD-like helicases superfamily; Region: DEXDc; smart00487
189423002242	ATP binding site [chemical binding]; other site
189423002243	putative Mg++ binding site [ion binding]; other site
189423002244	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
189423002245	nucleotide binding region [chemical binding]; other site
189423002246	ATP-binding site [chemical binding]; other site
189423002247	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
189423002248	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
189423002249	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
189423002250	peptidoglycan GlcNAc deacetylase, unverified frameshift
189423002251	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
189423002252	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
189423002253	active site
189423002254	catalytic tetrad [active]
189423002255	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
189423002256	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
189423002257	dimer interface [polypeptide binding]; other site
189423002258	motif 1; other site
189423002259	active site
189423002260	motif 2; other site
189423002261	motif 3; other site
189423002262	Glycyl-tRNA synthetase, beta subunit [Translation, ribosomal structure and biogenesis]; Region: GlyS; COG0751
189423002263	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471
189423002264	DALR anticodon binding domain; Region: DALR_1; pfam05746
189423002265	hypothetical protein; Provisional; Region: PRK02539
189423002266	Predicted flavoprotein [General function prediction only]; Region: COG0431
189423002267	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
189423002268	PAS domain; Region: PAS_10; pfam13596
189423002269	Predicted flavoprotein [General function prediction only]; Region: COG0431
189423002270	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
189423002271	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
189423002272	ApbE family; Region: ApbE; pfam02424
189423002273	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
189423002274	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
189423002275	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
189423002276	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
189423002277	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
189423002278	active site
189423002279	multimer interface [polypeptide binding]; other site
189423002280	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
189423002281	predicted active site [active]
189423002282	catalytic triad [active]
189423002283	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
189423002284	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
189423002285	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
189423002286	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
189423002287	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
189423002288	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
189423002289	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
189423002290	DNA binding site [nucleotide binding]
189423002291	active site
189423002292	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
189423002293	putative ArsC-like catalytic residues; other site
189423002294	putative TRX-like catalytic residues [active]
189423002295	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
189423002296	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
189423002297	ABC-ATPase subunit interface; other site
189423002298	putative PBP binding loops; other site
189423002299	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
189423002300	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
189423002301	Walker A/P-loop; other site
189423002302	ATP binding site [chemical binding]; other site
189423002303	Q-loop/lid; other site
189423002304	ABC transporter signature motif; other site
189423002305	Walker B; other site
189423002306	D-loop; other site
189423002307	H-loop/switch region; other site
189423002308	Protein of unknown function (DUF4059); Region: DUF4059; pfam13268
189423002309	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
189423002310	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
189423002311	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
189423002312	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
189423002313	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
189423002314	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
189423002315	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
189423002316	active site
189423002317	catalytic residues [active]
189423002318	metal binding site [ion binding]; metal-binding site
189423002319	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
189423002320	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
189423002321	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
189423002322	putative active site [active]
189423002323	putative metal binding site [ion binding]; other site
189423002324	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
189423002325	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
189423002326	active site
189423002327	motif I; other site
189423002328	motif II; other site
189423002329	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
189423002330	NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841
189423002331	active site
189423002332	catalytic triad [active]
189423002333	oxyanion hole [active]
189423002334	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
189423002335	Beta-lactamase; Region: Beta-lactamase; pfam00144
189423002336	EamA-like transporter family; Region: EamA; pfam00892
189423002337	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
189423002338	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
189423002339	DNA-binding site [nucleotide binding]; DNA binding site
189423002340	UTRA domain; Region: UTRA; pfam07702
189423002341	GMP synthase; Reviewed; Region: guaA; PRK00074
189423002342	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
189423002343	AMP/PPi binding site [chemical binding]; other site
189423002344	candidate oxyanion hole; other site
189423002345	catalytic triad [active]
189423002346	potential glutamine specificity residues [chemical binding]; other site
189423002347	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
189423002348	ATP Binding subdomain [chemical binding]; other site
189423002349	Dimerization subdomain; other site
189423002350	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
189423002351	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
189423002352	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
189423002353	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
189423002354	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
189423002355	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
189423002356	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
189423002357	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
189423002358	Walker A/P-loop; other site
189423002359	ATP binding site [chemical binding]; other site
189423002360	ABC transporter; Region: ABC_tran; pfam00005
189423002361	Q-loop/lid; other site
189423002362	ABC transporter signature motif; other site
189423002363	Walker B; other site
189423002364	D-loop; other site
189423002365	H-loop/switch region; other site
189423002366	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
189423002367	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
189423002368	Walker A/P-loop; other site
189423002369	ATP binding site [chemical binding]; other site
189423002370	Q-loop/lid; other site
189423002371	ABC transporter signature motif; other site
189423002372	Walker B; other site
189423002373	D-loop; other site
189423002374	H-loop/switch region; other site
189423002375	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
189423002376	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605
189423002377	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
189423002378	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
189423002379	Walker A/P-loop; other site
189423002380	ATP binding site [chemical binding]; other site
189423002381	Q-loop/lid; other site
189423002382	ABC transporter signature motif; other site
189423002383	Walker B; other site
189423002384	D-loop; other site
189423002385	H-loop/switch region; other site
189423002386	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
189423002387	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
189423002388	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
189423002389	Walker A/P-loop; other site
189423002390	ATP binding site [chemical binding]; other site
189423002391	Q-loop/lid; other site
189423002392	ABC transporter signature motif; other site
189423002393	Walker B; other site
189423002394	D-loop; other site
189423002395	H-loop/switch region; other site
189423002396	Helix-turn-helix domain; Region: HTH_18; pfam12833
189423002397	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
189423002398	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
189423002399	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
189423002400	S-adenosylmethionine binding site [chemical binding]; other site
189423002401	ApaLI-like restriction endonuclease; Region: RE_ApaLI; pfam09499
189423002402	ApaLI-like restriction endonuclease; Region: RE_ApaLI; pfam09499
189423002403	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
189423002404	Peptidase family U32; Region: Peptidase_U32; pfam01136
189423002405	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
189423002406	Peptidase family U32; Region: Peptidase_U32; pfam01136
189423002407	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
189423002408	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
189423002409	ABC transporter; Region: ABC_tran; pfam00005
189423002410	Q-loop/lid; other site
189423002411	ABC transporter signature motif; other site
189423002412	Walker B; other site
189423002413	D-loop; other site
189423002414	H-loop/switch region; other site
189423002415	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
189423002416	non-specific DNA binding site [nucleotide binding]; other site
189423002417	salt bridge; other site
189423002418	sequence-specific DNA binding site [nucleotide binding]; other site
189423002419	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
189423002420	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
189423002421	active site
189423002422	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
189423002423	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
189423002424	homodimer interface [polypeptide binding]; other site
189423002425	NAD binding pocket [chemical binding]; other site
189423002426	ATP binding pocket [chemical binding]; other site
189423002427	Mg binding site [ion binding]; other site
189423002428	active-site loop [active]
189423002429	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
189423002430	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
189423002431	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
189423002432	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
189423002433	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
189423002434	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
189423002435	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
189423002436	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
189423002437	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
189423002438	active site
189423002439	trimer interface [polypeptide binding]; other site
189423002440	allosteric site; other site
189423002441	active site lid [active]
189423002442	hexamer (dimer of trimers) interface [polypeptide binding]; other site
189423002443	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
189423002444	HPr kinase/phosphorylase; Provisional; Region: PRK05428
189423002445	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
189423002446	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
189423002447	Hpr binding site; other site
189423002448	active site
189423002449	homohexamer subunit interaction site [polypeptide binding]; other site
189423002450	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
189423002451	Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768
189423002452	YtxH-like protein; Region: YtxH; pfam12732
189423002453	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
189423002454	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
189423002455	FeS/SAM binding site; other site
189423002456	HemN C-terminal domain; Region: HemN_C; pfam06969
189423002457	Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884
189423002458	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
189423002459	active site
189423002460	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
189423002461	active site
189423002462	HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2
189423002463	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
189423002464	active site
189423002465	motif I; other site
189423002466	motif II; other site
189423002467	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
189423002468	Predicted membrane protein [Function unknown]; Region: COG4478
189423002469	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
189423002470	ArsC family; Region: ArsC; pfam03960
189423002471	putative catalytic residues [active]
189423002472	thiol/disulfide switch; other site
189423002473	Uncharacterized protein family (UPF0223); Region: UPF0223; cl11484
189423002474	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
189423002475	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
189423002476	active site
189423002477	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
189423002478	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
189423002479	S-adenosylmethionine binding site [chemical binding]; other site
189423002480	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
189423002481	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
189423002482	phosphate binding protein; Region: ptsS_2; TIGR02136
189423002483	sulfate transport protein; Provisional; Region: cysT; CHL00187
189423002484	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
189423002485	dimer interface [polypeptide binding]; other site
189423002486	conserved gate region; other site
189423002487	putative PBP binding loops; other site
189423002488	ABC-ATPase subunit interface; other site
189423002489	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
189423002490	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
189423002491	dimer interface [polypeptide binding]; other site
189423002492	conserved gate region; other site
189423002493	putative PBP binding loops; other site
189423002494	ABC-ATPase subunit interface; other site
189423002495	phosphate transporter ATP-binding protein; Provisional; Region: PRK14237
189423002496	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
189423002497	Walker A/P-loop; other site
189423002498	ATP binding site [chemical binding]; other site
189423002499	Q-loop/lid; other site
189423002500	ABC transporter signature motif; other site
189423002501	Walker B; other site
189423002502	D-loop; other site
189423002503	H-loop/switch region; other site
189423002504	phosphate transporter ATP-binding protein; Provisional; Region: PRK14239
189423002505	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
189423002506	Walker A/P-loop; other site
189423002507	ATP binding site [chemical binding]; other site
189423002508	Q-loop/lid; other site
189423002509	ABC transporter signature motif; other site
189423002510	Walker B; other site
189423002511	D-loop; other site
189423002512	H-loop/switch region; other site
189423002513	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
189423002514	PhoU domain; Region: PhoU; pfam01895
189423002515	PhoU domain; Region: PhoU; pfam01895
189423002516	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
189423002517	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
189423002518	substrate binding pocket [chemical binding]; other site
189423002519	membrane-bound complex binding site; other site
189423002520	hinge residues; other site
189423002521	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
189423002522	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
189423002523	DNA-binding site [nucleotide binding]; DNA binding site
189423002524	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
189423002525	pyridoxal 5'-phosphate binding site [chemical binding]; other site
189423002526	homodimer interface [polypeptide binding]; other site
189423002527	catalytic residue [active]
189423002528	Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527
189423002529	Putative membrane peptidase family (DUF2324); Region: DUF2324; cl01810
189423002530	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
189423002531	FAD binding domain; Region: FAD_binding_4; pfam01565
189423002532	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
189423002533	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
189423002534	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
189423002535	Walker A/P-loop; other site
189423002536	ATP binding site [chemical binding]; other site
189423002537	Q-loop/lid; other site
189423002538	ABC transporter signature motif; other site
189423002539	Walker B; other site
189423002540	D-loop; other site
189423002541	H-loop/switch region; other site
189423002542	TOBE domain; Region: TOBE_2; pfam08402
189423002543	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
189423002544	dimer interface [polypeptide binding]; other site
189423002545	conserved gate region; other site
189423002546	putative PBP binding loops; other site
189423002547	ABC-ATPase subunit interface; other site
189423002548	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
189423002549	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
189423002550	dimer interface [polypeptide binding]; other site
189423002551	conserved gate region; other site
189423002552	putative PBP binding loops; other site
189423002553	ABC-ATPase subunit interface; other site
189423002554	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
189423002555	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
189423002556	Uncharacterized conserved protein [Function unknown]; Region: COG4894
189423002557	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
189423002558	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
189423002559	motif 1; other site
189423002560	active site
189423002561	motif 2; other site
189423002562	motif 3; other site
189423002563	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
189423002564	DHHA1 domain; Region: DHHA1; pfam02272
189423002565	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
189423002566	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
189423002567	active site
189423002568	Na/Ca binding site [ion binding]; other site
189423002569	catalytic site [active]
189423002570	Domain of unknown function (DUF1939); Region: DUF1939; pfam09154
189423002571	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
189423002572	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
189423002573	Walker A/P-loop; other site
189423002574	ATP binding site [chemical binding]; other site
189423002575	Q-loop/lid; other site
189423002576	ABC transporter signature motif; other site
189423002577	Walker B; other site
189423002578	D-loop; other site
189423002579	H-loop/switch region; other site
189423002580	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
189423002581	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
189423002582	putative RNA binding site [nucleotide binding]; other site
189423002583	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
189423002584	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
189423002585	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
189423002586	active site
189423002587	catalytic residue [active]
189423002588	dimer interface [polypeptide binding]; other site
189423002589	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
189423002590	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
189423002591	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
189423002592	shikimate binding site; other site
189423002593	NAD(P) binding site [chemical binding]; other site
189423002594	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
189423002595	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
189423002596	active site
189423002597	dimer interface [polypeptide binding]; other site
189423002598	metal binding site [ion binding]; metal-binding site
189423002599	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
189423002600	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
189423002601	Tetramer interface [polypeptide binding]; other site
189423002602	active site
189423002603	FMN-binding site [chemical binding]; other site
189423002604	prephenate dehydrogenase; Validated; Region: PRK06545
189423002605	prephenate dehydrogenase; Validated; Region: PRK08507
189423002606	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
189423002607	hypothetical protein; Provisional; Region: PRK13676
189423002608	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
189423002609	Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554
189423002610	hinge; other site
189423002611	active site
189423002612	shikimate kinase; Reviewed; Region: aroK; PRK00131
189423002613	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
189423002614	ADP binding site [chemical binding]; other site
189423002615	magnesium binding site [ion binding]; other site
189423002616	putative shikimate binding site; other site
189423002617	prephenate dehydratase; Provisional; Region: PRK11898
189423002618	Prephenate dehydratase; Region: PDT; pfam00800
189423002619	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
189423002620	putative L-Phe binding site [chemical binding]; other site
189423002621	Transcriptional regulator [Transcription]; Region: LytR; COG1316
189423002622	LPS biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3475
189423002623	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
189423002624	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
189423002625	putative ADP-binding pocket [chemical binding]; other site
189423002626	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
189423002627	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
189423002628	active site
189423002629	O-antigen polysaccharide polymerase Wzy; Region: O-ag_pol_Wzy; pfam14296
189423002630	Malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate cycle, which allows certain organisms, like plants and fungi, to derive their...; Region: malate_synt; cl17217
189423002631	adaptor protein; Provisional; Region: PRK02315
189423002632	homoserine dehydrogenase; Provisional; Region: PRK06349
189423002633	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
189423002634	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
189423002635	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
189423002636	homoserine kinase; Provisional; Region: PRK01212
189423002637	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
189423002638	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
189423002639	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
189423002640	SelR domain; Region: SelR; pfam01641
189423002641	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
189423002642	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
189423002643	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
189423002644	Walker A/P-loop; other site
189423002645	ATP binding site [chemical binding]; other site
189423002646	Q-loop/lid; other site
189423002647	ABC transporter signature motif; other site
189423002648	Walker B; other site
189423002649	D-loop; other site
189423002650	H-loop/switch region; other site
189423002651	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
189423002652	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
189423002653	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
189423002654	Walker A/P-loop; other site
189423002655	ATP binding site [chemical binding]; other site
189423002656	Q-loop/lid; other site
189423002657	ABC transporter signature motif; other site
189423002658	Walker B; other site
189423002659	D-loop; other site
189423002660	H-loop/switch region; other site
189423002661	chlorohydrolase; Validated; Region: PRK06687
189423002662	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
189423002663	active site
189423002664	putative substrate binding pocket [chemical binding]; other site
189423002665	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
189423002666	23S rRNA interface [nucleotide binding]; other site
189423002667	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
189423002668	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
189423002669	core dimer interface [polypeptide binding]; other site
189423002670	L10 interface [polypeptide binding]; other site
189423002671	L11 interface [polypeptide binding]; other site
189423002672	putative EF-Tu interaction site [polypeptide binding]; other site
189423002673	putative EF-G interaction site [polypeptide binding]; other site
189423002674	CAAX protease self-immunity; Region: Abi; pfam02517
189423002675	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
189423002676	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
189423002677	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
189423002678	putative active site [active]
189423002679	Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010
189423002680	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
189423002681	putative active site cavity [active]
189423002682	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
189423002683	N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954
189423002684	inhibitor site; inhibition site
189423002685	active site
189423002686	dimer interface [polypeptide binding]; other site
189423002687	catalytic residue [active]
189423002688	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495
189423002689	Na binding site [ion binding]; other site
189423002690	Domain of unknown function (DUF386); Region: DUF386; pfam04074
189423002691	Neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: NanH; COG4409
189423002692	Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated...; Region: PTX; cl00102
189423002693	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
189423002694	Asp-box motif; other site
189423002695	catalytic site [active]
189423002696	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
189423002697	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
189423002698	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
189423002699	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
189423002700	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
189423002701	V-type ATP synthase subunit I; Validated; Region: PRK05771
189423002702	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
189423002703	V-type ATP synthase subunit K; Validated; Region: PRK06558
189423002704	ATP synthase subunit C; Region: ATP-synt_C; pfam00137
189423002705	ATP synthase subunit C; Region: ATP-synt_C; pfam00137
189423002706	Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390
189423002707	Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527
189423002708	V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660
189423002709	V-type ATP synthase subunit F; Provisional; Region: PRK01395
189423002710	V-type ATP synthase subunit A; Provisional; Region: PRK04192
189423002711	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
189423002712	V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction.  The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134
189423002713	Walker A motif/ATP binding site; other site
189423002714	Walker B motif; other site
189423002715	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
189423002716	V-type ATP synthase subunit B; Provisional; Region: PRK04196
189423002717	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
189423002718	V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135
189423002719	Walker A motif homologous position; other site
189423002720	Walker B motif; other site
189423002721	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
189423002722	V-type ATP synthase subunit D; Reviewed; Region: PRK00373
189423002723	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
189423002724	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
189423002725	DDE superfamily endonuclease; Region: DDE_3; pfam13358
189423002726	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
189423002727	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
189423002728	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
189423002729	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
189423002730	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
189423002731	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
189423002732	ABC transporter signature motif; other site
189423002733	Walker B; other site
189423002734	D-loop; other site
189423002735	H-loop/switch region; other site
189423002736	glutamate dehydrogenase; Provisional; Region: PRK09414
189423002737	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
189423002738	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
189423002739	NAD(P) binding site [chemical binding]; other site
189423002740	Winged helix-turn helix; Region: HTH_33; pfam13592
189423002741	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
189423002742	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
189423002743	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
189423002744	DHH family; Region: DHH; pfam01368
189423002745	flavodoxin; Validated; Region: PRK07308
189423002746	hypothetical protein; Provisional; Region: PRK07248
189423002747	camphor resistance protein CrcB; Provisional; Region: PRK14221
189423002748	camphor resistance protein CrcB; Provisional; Region: PRK14229
189423002749	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
189423002750	sugar phosphate phosphatase; Provisional; Region: PRK10513
189423002751	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
189423002752	active site
189423002753	motif I; other site
189423002754	motif II; other site
189423002755	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
189423002756	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
189423002757	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
189423002758	Zn2+ binding site [ion binding]; other site
189423002759	Mg2+ binding site [ion binding]; other site
189423002760	Domain of unknown function (DUF1934); Region: DUF1934; pfam09148
189423002761	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
189423002762	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
189423002763	signal recognition particle protein; Provisional; Region: PRK10867
189423002764	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
189423002765	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
189423002766	P loop; other site
189423002767	GTP binding site [chemical binding]; other site
189423002768	Signal peptide binding domain; Region: SRP_SPB; pfam02978
189423002769	uracil transporter; Provisional; Region: PRK10720
189423002770	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
189423002771	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
189423002772	S-adenosylmethionine binding site [chemical binding]; other site
189423002773	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
189423002774	heat shock protein HtpX; Provisional; Region: PRK04897
189423002775	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
189423002776	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
189423002777	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
189423002778	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
189423002779	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
189423002780	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
189423002781	minor groove reading motif; other site
189423002782	helix-hairpin-helix signature motif; other site
189423002783	substrate binding pocket [chemical binding]; other site
189423002784	active site
189423002785	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
189423002786	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
189423002787	active site
189423002788	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
189423002789	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
189423002790	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
189423002791	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
189423002792	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
189423002793	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
189423002794	catalytic site [active]
189423002795	subunit interface [polypeptide binding]; other site
189423002796	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
189423002797	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
189423002798	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
189423002799	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
189423002800	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
189423002801	ATP-grasp domain; Region: ATP-grasp_4; cl17255
189423002802	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
189423002803	IMP binding site; other site
189423002804	dimer interface [polypeptide binding]; other site
189423002805	interdomain contacts; other site
189423002806	partial ornithine binding site; other site
189423002807	LPS biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3475
189423002808	LPS biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3475
189423002809	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
189423002810	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
189423002811	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
189423002812	substrate binding site; other site
189423002813	dimer interface; other site
189423002814	ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237
189423002815	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
189423002816	putative NAD(P) binding site [chemical binding]; other site
189423002817	putative catalytic Zn binding site [ion binding]; other site
189423002818	Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151
189423002819	Phosphotransferase enzyme family; Region: APH; pfam01636
189423002820	active site
189423002821	substrate binding site [chemical binding]; other site
189423002822	ATP binding site [chemical binding]; other site
189423002823	dimer interface [polypeptide binding]; other site
189423002824	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
189423002825	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
189423002826	active site
189423002827	metal-binding site
189423002828	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
189423002829	DNA protecting protein DprA; Region: dprA; TIGR00732
189423002830	potential frameshift: common BLAST hit: gi|298502739|ref|YP_003724679.1| membrane protein
189423002831	Predicted membrane protein [Function unknown]; Region: COG1808
189423002832	Predicted membrane protein [Function unknown]; Region: COG1808
189423002833	DNA topoisomerase I; Validated; Region: PRK05582
189423002834	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
189423002835	active site
189423002836	interdomain interaction site; other site
189423002837	putative metal-binding site [ion binding]; other site
189423002838	nucleotide binding site [chemical binding]; other site
189423002839	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
189423002840	domain I; other site
189423002841	DNA binding groove [nucleotide binding]
189423002842	phosphate binding site [ion binding]; other site
189423002843	domain II; other site
189423002844	domain III; other site
189423002845	nucleotide binding site [chemical binding]; other site
189423002846	catalytic site [active]
189423002847	domain IV; other site
189423002848	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
189423002849	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
189423002850	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
189423002851	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
189423002852	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
189423002853	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
189423002854	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
189423002855	metal binding site [ion binding]; metal-binding site
189423002856	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
189423002857	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
189423002858	tartrate dehydrogenase; Region: TTC; TIGR02089
189423002859	Predicted membrane protein [Function unknown]; Region: COG3326
189423002860	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
189423002861	substrate binding site [chemical binding]; other site
189423002862	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
189423002863	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251
189423002864	GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401
189423002865	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
189423002866	Walker A motif; other site
189423002867	ATP binding site [chemical binding]; other site
189423002868	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
189423002869	McrBC 5-methylcytosine restriction system component [Defense mechanisms]; Region: McrC; COG4268
189423002870	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
189423002871	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
189423002872	active site
189423002873	ribonuclease III; Reviewed; Region: rnc; PRK00102
189423002874	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
189423002875	dimerization interface [polypeptide binding]; other site
189423002876	active site
189423002877	metal binding site [ion binding]; metal-binding site
189423002878	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
189423002879	dsRNA binding site [nucleotide binding]; other site
189423002880	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
189423002881	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
189423002882	Walker A/P-loop; other site
189423002883	ATP binding site [chemical binding]; other site
189423002884	Q-loop/lid; other site
189423002885	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
189423002886	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
189423002887	ABC transporter signature motif; other site
189423002888	Walker B; other site
189423002889	D-loop; other site
189423002890	H-loop/switch region; other site
189423002891	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
189423002892	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
189423002893	active site
189423002894	motif I; other site
189423002895	motif II; other site
189423002896	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
189423002897	sugar phosphate phosphatase; Provisional; Region: PRK10513
189423002898	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
189423002899	motif II; other site
189423002900	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
189423002901	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
189423002902	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
189423002903	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
189423002904	P loop; other site
189423002905	GTP binding site [chemical binding]; other site
189423002906	Transposase; Region: DDE_Tnp_ISL3; pfam01610
189423002907	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
189423002908	Transposase; Region: DDE_Tnp_ISL3; pfam01610
189423002909	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
189423002910	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
189423002911	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
189423002912	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
189423002913	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
189423002914	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
189423002915	Walker A/P-loop; other site
189423002916	ATP binding site [chemical binding]; other site
189423002917	Q-loop/lid; other site
189423002918	ABC transporter signature motif; other site
189423002919	Walker B; other site
189423002920	D-loop; other site
189423002921	H-loop/switch region; other site
189423002922	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
189423002923	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
189423002924	substrate binding pocket [chemical binding]; other site
189423002925	membrane-bound complex binding site; other site
189423002926	hinge residues; other site
189423002927	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
189423002928	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
189423002929	substrate binding pocket [chemical binding]; other site
189423002930	membrane-bound complex binding site; other site
189423002931	hinge residues; other site
189423002932	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
189423002933	dimer interface [polypeptide binding]; other site
189423002934	conserved gate region; other site
189423002935	putative PBP binding loops; other site
189423002936	ABC-ATPase subunit interface; other site
189423002937	CAAX protease self-immunity; Region: Abi; pfam02517
189423002938	UvrABC system protein B, unverified frameshift
189423002939	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
189423002940	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
189423002941	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
189423002942	Coenzyme A binding pocket [chemical binding]; other site
189423002943	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
189423002944	putative active site [active]
189423002945	nucleotide binding site [chemical binding]; other site
189423002946	nudix motif; other site
189423002947	putative metal binding site [ion binding]; other site
189423002948	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
189423002949	HTH domain; Region: HTH_11; pfam08279
189423002950	3H domain; Region: 3H; pfam02829
189423002951	Predicted membrane protein [Function unknown]; Region: COG4684
189423002952	phosphopantothenoylcysteine decarboxylase, streptococcal; Region: coaC_strep; TIGR02113
189423002953	Flavoprotein; Region: Flavoprotein; pfam02441
189423002954	phosphopantothenate--cysteine ligase; Validated; Region: PRK06732
189423002955	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
189423002956	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
189423002957	Potassium binding sites [ion binding]; other site
189423002958	Cesium cation binding sites [ion binding]; other site
189423002959	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
189423002960	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
189423002961	minor groove reading motif; other site
189423002962	helix-hairpin-helix signature motif; other site
189423002963	substrate binding pocket [chemical binding]; other site
189423002964	active site
189423002965	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
189423002966	DNA binding and oxoG recognition site [nucleotide binding]
189423002967	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
189423002968	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
189423002969	active site
189423002970	phosphorylation site [posttranslational modification]
189423002971	intermolecular recognition site; other site
189423002972	dimerization interface [polypeptide binding]; other site
189423002973	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
189423002974	DNA binding site [nucleotide binding]
189423002975	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
189423002976	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
189423002977	putative active site [active]
189423002978	heme pocket [chemical binding]; other site
189423002979	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
189423002980	dimer interface [polypeptide binding]; other site
189423002981	phosphorylation site [posttranslational modification]
189423002982	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
189423002983	ATP binding site [chemical binding]; other site
189423002984	Mg2+ binding site [ion binding]; other site
189423002985	G-X-G motif; other site
189423002986	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
189423002987	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
189423002988	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
189423002989	Ion channel; Region: Ion_trans_2; pfam07885
189423002990	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
189423002991	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
189423002992	tetramer (dimer of dimers) interface [polypeptide binding]; other site
189423002993	NAD binding site [chemical binding]; other site
189423002994	dimer interface [polypeptide binding]; other site
189423002995	substrate binding site [chemical binding]; other site
189423002996	DNA gyrase subunit A; Validated; Region: PRK05560
189423002997	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
189423002998	CAP-like domain; other site
189423002999	active site
189423003000	primary dimer interface [polypeptide binding]; other site
189423003001	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
189423003002	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
189423003003	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
189423003004	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
189423003005	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
189423003006	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
189423003007	Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165
189423003008	active site
189423003009	catalytic site [active]
189423003010	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
189423003011	Dppa2/4 conserved region; Region: DCR; pfam14047
189423003012	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
189423003013	hypothetical protein; Provisional; Region: PRK05939
189423003014	homodimer interface [polypeptide binding]; other site
189423003015	substrate-cofactor binding pocket; other site
189423003016	pyridoxal 5'-phosphate binding site [chemical binding]; other site
189423003017	catalytic residue [active]
189423003018	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487
189423003019	Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903
189423003020	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484
189423003021	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
189423003022	RNA binding site [nucleotide binding]; other site
189423003023	active site
189423003024	tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
189423003025	Enterocin A Immunity; Region: EntA_Immun; pfam08951
189423003026	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
189423003027	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
189423003028	Sugar specificity; other site
189423003029	Pyrimidine base specificity; other site
189423003030	ATP-binding site [chemical binding]; other site
189423003031	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
189423003032	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
189423003033	generic binding surface II; other site
189423003034	generic binding surface I; other site
189423003035	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
189423003036	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
189423003037	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
189423003038	substrate binding pocket [chemical binding]; other site
189423003039	chain length determination region; other site
189423003040	substrate-Mg2+ binding site; other site
189423003041	catalytic residues [active]
189423003042	aspartate-rich region 1; other site
189423003043	active site lid residues [active]
189423003044	aspartate-rich region 2; other site
189423003045	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
189423003046	S4 RNA-binding domain; Region: S4; smart00363
189423003047	RNA binding surface [nucleotide binding]; other site
189423003048	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
189423003049	Arginine repressor [Transcription]; Region: ArgR; COG1438
189423003050	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
189423003051	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
189423003052	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
189423003053	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
189423003054	Walker A/P-loop; other site
189423003055	ATP binding site [chemical binding]; other site
189423003056	Q-loop/lid; other site
189423003057	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
189423003058	ABC transporter signature motif; other site
189423003059	Walker B; other site
189423003060	D-loop; other site
189423003061	H-loop/switch region; other site
189423003062	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
189423003063	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
189423003064	active site
189423003065	metal binding site [ion binding]; metal-binding site
189423003066	GTP-binding protein LepA; Provisional; Region: PRK05433
189423003067	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
189423003068	G1 box; other site
189423003069	putative GEF interaction site [polypeptide binding]; other site
189423003070	GTP/Mg2+ binding site [chemical binding]; other site
189423003071	Switch I region; other site
189423003072	G2 box; other site
189423003073	G3 box; other site
189423003074	Switch II region; other site
189423003075	G4 box; other site
189423003076	G5 box; other site
189423003077	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
189423003078	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
189423003079	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
189423003080	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
189423003081	active site
189423003082	phosphorylation site [posttranslational modification]
189423003083	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
189423003084	active site
189423003085	P-loop; other site
189423003086	phosphorylation site [posttranslational modification]
189423003087	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
189423003088	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
189423003089	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
189423003090	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
189423003091	catalytic residues [active]
189423003092	galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621
189423003093	galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622
189423003094	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
189423003095	tagatose-6-phosphate kinase; Region: lacC; TIGR01231
189423003096	putative substrate binding site [chemical binding]; other site
189423003097	putative ATP binding site [chemical binding]; other site
189423003098	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399
189423003099	CAT RNA binding domain; Region: CAT_RBD; smart01061
189423003100	transcriptional antiterminator BglG; Provisional; Region: PRK09772
189423003101	PRD domain; Region: PRD; pfam00874
189423003102	PRD domain; Region: PRD; pfam00874
189423003103	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
189423003104	methionine cluster; other site
189423003105	active site
189423003106	phosphorylation site [posttranslational modification]
189423003107	metal binding site [ion binding]; metal-binding site
189423003108	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295
189423003109	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
189423003110	PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565
189423003111	active site
189423003112	P-loop; other site
189423003113	phosphorylation site [posttranslational modification]
189423003114	6-phospho-beta-galactosidase; Provisional; Region: PRK13511
189423003115	beta-galactosidase; Region: BGL; TIGR03356
189423003116	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
189423003117	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
189423003118	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
189423003119	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
189423003120	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
189423003121	dimer interface [polypeptide binding]; other site
189423003122	putative radical transfer pathway; other site
189423003123	diiron center [ion binding]; other site
189423003124	tyrosyl radical; other site
189423003125	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306
189423003126	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
189423003127	Class I ribonucleotide reductase; Region: RNR_I; cd01679
189423003128	active site
189423003129	dimer interface [polypeptide binding]; other site
189423003130	catalytic residues [active]
189423003131	effector binding site; other site
189423003132	R2 peptide binding site; other site
189423003133	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
189423003134	catalytic residues [active]
189423003135	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
189423003136	dimerization domain swap beta strand [polypeptide binding]; other site
189423003137	regulatory protein interface [polypeptide binding]; other site
189423003138	active site
189423003139	regulatory phosphorylation site [posttranslational modification]; other site
189423003140	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
189423003141	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
189423003142	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
189423003143	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
189423003144	streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363
189423003145	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
189423003146	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
189423003147	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
189423003148	streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363
189423003149	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
189423003150	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
189423003151	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
189423003152	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
189423003153	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
189423003154	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
189423003155	motif II; other site
189423003156	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
189423003157	ligand binding site [chemical binding]; other site
189423003158	active site
189423003159	UGI interface [polypeptide binding]; other site
189423003160	catalytic site [active]
189423003161	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
189423003162	putative active site [active]
189423003163	nucleotide binding site [chemical binding]; other site
189423003164	nudix motif; other site
189423003165	putative metal binding site [ion binding]; other site
189423003166	dihydroorotase; Validated; Region: pyrC; PRK09357
189423003167	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
189423003168	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
189423003169	active site
189423003170	multidrug efflux protein; Reviewed; Region: PRK01766
189423003171	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
189423003172	cation binding site [ion binding]; other site
189423003173	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
189423003174	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
189423003175	tetramer interface [polypeptide binding]; other site
189423003176	TPP-binding site [chemical binding]; other site
189423003177	heterodimer interface [polypeptide binding]; other site
189423003178	phosphorylation loop region [posttranslational modification]
189423003179	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
189423003180	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
189423003181	alpha subunit interface [polypeptide binding]; other site
189423003182	TPP binding site [chemical binding]; other site
189423003183	heterodimer interface [polypeptide binding]; other site
189423003184	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
189423003185	dihydrolipoamide acetyltransferase; Provisional; Region: PRK14843
189423003186	e3 binding domain; Region: E3_binding; pfam02817
189423003187	e3 binding domain; Region: E3_binding; pfam02817
189423003188	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
189423003189	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
189423003190	E3 interaction surface; other site
189423003191	lipoyl attachment site [posttranslational modification]; other site
189423003192	dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350
189423003193	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
189423003194	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
189423003195	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
189423003196	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
189423003197	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
189423003198	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
189423003199	site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084
189423003200	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
189423003201	active site
189423003202	DNA binding site [nucleotide binding]
189423003203	Int/Topo IB signature motif; other site
189423003204	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
189423003205	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
189423003206	Cl- selectivity filter; other site
189423003207	Cl- binding residues [ion binding]; other site
189423003208	pore gating glutamate residue; other site
189423003209	dimer interface [polypeptide binding]; other site
189423003210	H+/Cl- coupling transport residue; other site
189423003211	TrkA-C domain; Region: TrkA_C; pfam02080
189423003212	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
189423003213	RNA/DNA hybrid binding site [nucleotide binding]; other site
189423003214	active site
189423003215	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
189423003216	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
189423003217	GTP/Mg2+ binding site [chemical binding]; other site
189423003218	G4 box; other site
189423003219	G5 box; other site
189423003220	G1 box; other site
189423003221	Switch I region; other site
189423003222	G2 box; other site
189423003223	G3 box; other site
189423003224	Switch II region; other site
189423003225	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
189423003226	Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199
189423003227	Int/Topo IB signature motif; other site
189423003228	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
189423003229	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
189423003230	non-specific DNA binding site [nucleotide binding]; other site
189423003231	salt bridge; other site
189423003232	sequence-specific DNA binding site [nucleotide binding]; other site
189423003233	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
189423003234	Bacterial mobilisation protein (MobC); Region: MobC; pfam05713
189423003235	Divergent AAA domain; Region: AAA_4; pfam04326
189423003236	Part of AAA domain; Region: AAA_19; pfam13245
189423003237	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
189423003238	Family description; Region: UvrD_C_2; pfam13538
189423003239	AAA ATPase domain; Region: AAA_15; pfam13175
189423003240	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
189423003241	Walker A/P-loop; other site
189423003242	ATP binding site [chemical binding]; other site
189423003243	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
189423003244	putative active site [active]
189423003245	putative metal-binding site [ion binding]; other site
189423003246	Domain of unknown function (DUF4071); Region: DUF4071; pfam13281
189423003247	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
189423003248	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
189423003249	active site
189423003250	DNA binding site [nucleotide binding]
189423003251	Int/Topo IB signature motif; other site
189423003252	Zeta toxin; Region: Zeta_toxin; pfam06414
189423003253	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
189423003254	Transposase; Region: DDE_Tnp_ISL3; pfam01610
189423003255	Protein of unknown function (DUF3990); Region: DUF3990; pfam13151
189423003256	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
189423003257	Toprim-like; Region: Toprim_2; pfam13155
189423003258	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
189423003259	ABC transporter signature motif; other site
189423003260	Walker B; other site
189423003261	D-loop; other site
189423003262	H-loop/switch region; other site
189423003263	Replication protein; Region: Rep_1; cl02412
189423003264	Chloramphenicol acetyltransferase; Region: CAT; pfam00302
189423003265	Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845
189423003266	GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257
189423003267	GIY-YIG motif/motif A; other site
189423003268	active site
189423003269	catalytic site [active]
189423003270	Zeta toxin; Region: Zeta_toxin; pfam06414
189423003271	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
189423003272	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
189423003273	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
189423003274	non-specific DNA binding site [nucleotide binding]; other site
189423003275	salt bridge; other site
189423003276	sequence-specific DNA binding site [nucleotide binding]; other site
189423003277	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
189423003278	Toprim-like; Region: Toprim_2; pfam13155
189423003279	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
189423003280	non-specific DNA binding site [nucleotide binding]; other site
189423003281	salt bridge; other site
189423003282	sequence-specific DNA binding site [nucleotide binding]; other site
189423003283	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
189423003284	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
189423003285	DNA binding domain of tn916 integrase; Region: Integrase_DNA; pfam02920
189423003286	Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199
189423003287	Int/Topo IB signature motif; other site
189423003288	Excisionase from transposon Tn916; Region: Tn916-Xis; pfam09035
189423003289	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
189423003290	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
189423003291	DNA binding residues [nucleotide binding]
189423003292	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
189423003293	non-specific DNA binding site [nucleotide binding]; other site
189423003294	salt bridge; other site
189423003295	sequence-specific DNA binding site [nucleotide binding]; other site
189423003296	Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480
189423003297	Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168
189423003298	G1 box; other site
189423003299	putative GEF interaction site [polypeptide binding]; other site
189423003300	GTP/Mg2+ binding site [chemical binding]; other site
189423003301	Switch I region; other site
189423003302	G2 box; other site
189423003303	G3 box; other site
189423003304	Switch II region; other site
189423003305	G4 box; other site
189423003306	G5 box; other site
189423003307	Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690
189423003308	EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684
189423003309	Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711
189423003310	Conjugative transposon protein TcpC; Region: TpcC; pfam12642
189423003311	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
189423003312	N-acetyl-D-glucosamine binding site [chemical binding]; other site
189423003313	catalytic residue [active]
189423003314	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
189423003315	NlpC/P60 family; Region: NLPC_P60; pfam00877
189423003316	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
189423003317	Haemolysin-III related; Region: HlyIII; cl03831
189423003318	AAA-like domain; Region: AAA_10; pfam12846
189423003319	TcpE family; Region: TcpE; pfam12648
189423003320	Antirestriction protein (ArdA); Region: ArdA; pfam07275
189423003321	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
189423003322	Transposase; Region: DDE_Tnp_ISL3; pfam01610
189423003323	Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398
189423003324	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
189423003325	S-adenosylmethionine binding site [chemical binding]; other site
189423003326	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
189423003327	non-specific DNA binding site [nucleotide binding]; other site
189423003328	salt bridge; other site
189423003329	sequence-specific DNA binding site [nucleotide binding]; other site
189423003330	Replication initiation factor; Region: Rep_trans; pfam02486
189423003331	Omega Transcriptional Repressor; Region: Omega_Repress; pfam07764
189423003332	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
189423003333	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
189423003334	Walker A motif; other site
189423003335	ATP binding site [chemical binding]; other site
189423003336	Walker B motif; other site
189423003337	arginine finger; other site
189423003338	Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125
189423003339	Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125
189423003340	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
189423003341	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483
189423003342	ATP binding site [chemical binding]; other site
189423003343	substrate interface [chemical binding]; other site
189423003344	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
189423003345	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
189423003346	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
189423003347	Walker A/P-loop; other site
189423003348	ATP binding site [chemical binding]; other site
189423003349	Q-loop/lid; other site
189423003350	ABC transporter signature motif; other site
189423003351	Walker B; other site
189423003352	D-loop; other site
189423003353	H-loop/switch region; other site
189423003354	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
189423003355	S-adenosylmethionine binding site [chemical binding]; other site
189423003356	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
189423003357	DEAD-like helicases superfamily; Region: DEXDc; smart00487
189423003358	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
189423003359	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
189423003360	helicase superfamily c-terminal domain; Region: HELICc; smart00490
189423003361	Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320
189423003362	hypothetical protein; Provisional; Region: PRK08445
189423003363	Peptidase family M23; Region: Peptidase_M23; pfam01551
189423003364	CHAP domain; Region: CHAP; pfam05257
189423003365	AAA-like domain; Region: AAA_10; pfam12846
189423003366	PrgI family protein; Region: PrgI; pfam12666
189423003367	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503
189423003368	AAA-like domain; Region: AAA_10; pfam12846
189423003369	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
189423003370	Walker A motif; other site
189423003371	ATP binding site [chemical binding]; other site
189423003372	Walker B motif; other site
189423003373	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
189423003374	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
189423003375	CAAX protease self-immunity; Region: Abi; pfam02517
189423003376	CAAX protease self-immunity; Region: Abi; pfam02517
189423003377	Arsenate reductase and related proteins, glutaredoxin family [Inorganic ion transport and metabolism]; Region: ArsC; COG1393
189423003378	ArsC family; Region: ArsC; pfam03960
189423003379	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
189423003380	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
189423003381	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
189423003382	G5 domain; Region: G5; pfam07501
189423003383	M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342
189423003384	M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580
189423003385	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
189423003386	Part of AAA domain; Region: AAA_19; pfam13245
189423003387	Family description; Region: UvrD_C_2; pfam13538
189423003388	Family description; Region: UvrD_C_2; pfam13538
189423003389	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
189423003390	ATP-dependent nuclease subunit B; Region: rexB_recomb; TIGR02774
189423003391	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
189423003392	Helix-turn-helix domain; Region: HTH_28; pfam13518
189423003393	Winged helix-turn helix; Region: HTH_29; pfam13551
189423003394	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
189423003395	DDE superfamily endonuclease; Region: DDE_3; pfam13358
189423003396	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
189423003397	DNA binding site [nucleotide binding]
189423003398	active site
189423003399	Int/Topo IB signature motif; other site
189423003400	enolase; Provisional; Region: eno; PRK00077
189423003401	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
189423003402	dimer interface [polypeptide binding]; other site
189423003403	metal binding site [ion binding]; metal-binding site
189423003404	substrate binding pocket [chemical binding]; other site
189423003405	Uncharacterized conserved protein [Function unknown]; Region: COG5506
189423003406	glycerate kinase, unverified frameshift
189423003407	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
189423003408	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
189423003409	glycogen synthase; Provisional; Region: glgA; PRK00654
189423003410	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
189423003411	ADP-binding pocket [chemical binding]; other site
189423003412	homodimer interface [polypeptide binding]; other site
189423003413	glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092
189423003414	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
189423003415	active site
189423003416	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
189423003417	dimer interface [polypeptide binding]; other site
189423003418	N-terminal domain interface [polypeptide binding]; other site
189423003419	sulfate 1 binding site; other site
189423003420	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
189423003421	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
189423003422	ligand binding site; other site
189423003423	oligomer interface; other site
189423003424	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
189423003425	dimer interface [polypeptide binding]; other site
189423003426	N-terminal domain interface [polypeptide binding]; other site
189423003427	sulfate 1 binding site; other site
189423003428	glycogen branching enzyme; Provisional; Region: PRK12313
189423003429	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
189423003430	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
189423003431	active site
189423003432	catalytic site [active]
189423003433	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
189423003434	NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082
189423003435	NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412
189423003436	tetrameric interface [polypeptide binding]; other site
189423003437	activator binding site; other site
189423003438	NADP binding site [chemical binding]; other site
189423003439	substrate binding site [chemical binding]; other site
189423003440	catalytic residues [active]
189423003441	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cl04227
189423003442	pullulanase, type I; Region: pulA_typeI; TIGR02104
189423003443	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
189423003444	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
189423003445	Ca binding site [ion binding]; other site
189423003446	active site
189423003447	catalytic site [active]
189423003448	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
189423003449	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
189423003450	nucleotide binding pocket [chemical binding]; other site
189423003451	K-X-D-G motif; other site
189423003452	catalytic site [active]
189423003453	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
189423003454	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
189423003455	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
189423003456	Dimer interface [polypeptide binding]; other site
189423003457	BRCT sequence motif; other site
189423003458	H+ Antiporter protein; Region: 2A0121; TIGR00900
189423003459	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
189423003460	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
189423003461	non-specific DNA binding site [nucleotide binding]; other site
189423003462	salt bridge; other site
189423003463	sequence-specific DNA binding site [nucleotide binding]; other site
189423003464	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
189423003465	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
189423003466	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
189423003467	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
189423003468	ABC transporter; Region: ABC_tran_2; pfam12848
189423003469	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
189423003470	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
189423003471	IHF dimer interface [polypeptide binding]; other site
189423003472	IHF - DNA interface [nucleotide binding]; other site
189423003473	EDD domain protein, DegV family; Region: DegV; TIGR00762
189423003474	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
189423003475	Uncharacterized conserved protein [Function unknown]; Region: COG1284
189423003476	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
189423003477	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
189423003478	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
189423003479	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
189423003480	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
189423003481	active site
189423003482	Riboflavin kinase; Region: Flavokinase; smart00904
189423003483	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
189423003484	Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868
189423003485	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
189423003486	Predicted membrane protein [Function unknown]; Region: COG3619
189423003487	hypothetical protein; Validated; Region: PRK00153
189423003488	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
189423003489	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
189423003490	Transposase; Region: DDE_Tnp_ISL3; pfam01610
189423003491	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
189423003492	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
189423003493	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
189423003494	RNA binding surface [nucleotide binding]; other site
189423003495	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
189423003496	active site
189423003497	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
189423003498	ATP-NAD kinase; Region: NAD_kinase; pfam01513
189423003499	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
189423003500	synthetase active site [active]
189423003501	NTP binding site [chemical binding]; other site
189423003502	metal binding site [ion binding]; metal-binding site
189423003503	Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762
189423003504	putative active site [active]
189423003505	putative metal binding residues [ion binding]; other site
189423003506	signature motif; other site
189423003507	putative triphosphate binding site [ion binding]; other site
189423003508	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458
189423003509	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
189423003510	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
189423003511	active site
189423003512	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
189423003513	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
189423003514	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
189423003515	catalytic residue [active]
189423003516	Putative amino acid metabolism; Region: DUF1831; pfam08866
189423003517	AT-rich DNA-binding protein [General function prediction only]; Region: COG2344
189423003518	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
189423003519	CoA binding domain; Region: CoA_binding; pfam02629
189423003520	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
189423003521	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
189423003522	catalytic triad [active]
189423003523	hypothetical protein; Reviewed; Region: PRK00024
189423003524	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
189423003525	MPN+ (JAMM) motif; other site
189423003526	Zinc-binding site [ion binding]; other site
189423003527	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
189423003528	Part of AAA domain; Region: AAA_19; pfam13245
189423003529	Family description; Region: UvrD_C_2; pfam13538
189423003530	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
189423003531	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
189423003532	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
189423003533	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
189423003534	active site
189423003535	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
189423003536	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
189423003537	DNA-binding site [nucleotide binding]; DNA binding site
189423003538	DRTGG domain; Region: DRTGG; pfam07085
189423003539	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
189423003540	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
189423003541	active site 2 [active]
189423003542	active site 1 [active]
189423003543	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
189423003544	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
189423003545	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
189423003546	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
189423003547	hinge; other site
189423003548	active site
189423003549	GTPase CgtA; Reviewed; Region: obgE; PRK12297
189423003550	GTP1/OBG; Region: GTP1_OBG; pfam01018
189423003551	Obg GTPase; Region: Obg; cd01898
189423003552	G1 box; other site
189423003553	GTP/Mg2+ binding site [chemical binding]; other site
189423003554	Switch I region; other site
189423003555	G2 box; other site
189423003556	G3 box; other site
189423003557	Switch II region; other site
189423003558	G4 box; other site
189423003559	G5 box; other site
189423003560	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
189423003561	Protein of unknown function (DUF4044); Region: DUF4044; pfam13253
189423003562	Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983
189423003563	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
189423003564	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
189423003565	putative ADP-binding pocket [chemical binding]; other site
189423003566	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
189423003567	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
189423003568	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
189423003569	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
189423003570	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
189423003571	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
189423003572	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
189423003573	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
189423003574	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
189423003575	DNA binding residues [nucleotide binding]
189423003576	DNA primase; Validated; Region: dnaG; PRK05667
189423003577	CHC2 zinc finger; Region: zf-CHC2; pfam01807
189423003578	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
189423003579	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
189423003580	active site
189423003581	metal binding site [ion binding]; metal-binding site
189423003582	interdomain interaction site; other site
189423003583	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
189423003584	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
189423003585	Walker A/P-loop; other site
189423003586	ATP binding site [chemical binding]; other site
189423003587	Q-loop/lid; other site
189423003588	ABC transporter signature motif; other site
189423003589	Walker B; other site
189423003590	D-loop; other site
189423003591	H-loop/switch region; other site
189423003592	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
189423003593	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
189423003594	TM-ABC transporter signature motif; other site
189423003595	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
189423003596	zinc binding site [ion binding]; other site
189423003597	putative ligand binding site [chemical binding]; other site
189423003598	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
189423003599	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
189423003600	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
189423003601	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
189423003602	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
189423003603	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
189423003604	conserved cys residue [active]
189423003605	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
189423003606	Coenzyme A binding pocket [chemical binding]; other site
189423003607	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
189423003608	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
189423003609	active site
189423003610	homodimer interface [polypeptide binding]; other site
189423003611	catalytic site [active]
189423003612	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
189423003613	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
189423003614	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
189423003615	ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397
189423003616	Domain of unknown function (DUF4343); Region: DUF4343; pfam14243
189423003617	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
189423003618	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
189423003619	catalytic residues [active]
189423003620	Recombinase; Region: Recombinase; pfam07508
189423003621	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
189423003622	Domain of unknown function (DUF4286); Region: DUF4286; pfam14114
189423003623	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
189423003624	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
189423003625	Walker A/P-loop; other site
189423003626	ATP binding site [chemical binding]; other site
189423003627	Q-loop/lid; other site
189423003628	ABC transporter signature motif; other site
189423003629	Walker B; other site
189423003630	D-loop; other site
189423003631	H-loop/switch region; other site
189423003632	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
189423003633	ABC-ATPase subunit  interface; other site
189423003634	dimer interface [polypeptide binding]; other site
189423003635	putative PBP binding regions; other site
189423003636	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
189423003637	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
189423003638	ABC-ATPase subunit  interface; other site
189423003639	dimer interface [polypeptide binding]; other site
189423003640	putative PBP binding regions; other site
189423003641	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
189423003642	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
189423003643	siderophore binding site; other site
189423003644	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
189423003645	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
189423003646	TRAM domain; Region: TRAM; cl01282
189423003647	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
189423003648	S-adenosylmethionine binding site [chemical binding]; other site
189423003649	Predicted secreted protein [Function unknown]; Region: COG4086
189423003650	Protein of unknown function (DUF1002); Region: DUF1002; pfam06207
189423003651	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
189423003652	Lysozyme-like; Region: Lysozyme_like; pfam13702
189423003653	catalytic residue [active]
189423003654	37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473
189423003655	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
189423003656	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
189423003657	dimer interface [polypeptide binding]; other site
189423003658	active site
189423003659	glycine-pyridoxal phosphate binding site [chemical binding]; other site
189423003660	folate binding site [chemical binding]; other site
189423003661	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
189423003662	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
189423003663	Coenzyme A binding pocket [chemical binding]; other site
189423003664	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
189423003665	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
189423003666	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
189423003667	S-adenosylmethionine binding site [chemical binding]; other site
189423003668	peptide chain release factor 1; Validated; Region: prfA; PRK00591
189423003669	This domain is found in peptide chain release factors; Region: PCRF; smart00937
189423003670	RF-1 domain; Region: RF-1; pfam00472
189423003671	thymidine kinase; Provisional; Region: PRK04296
189423003672	4-oxalocrotonate tautomerase; Provisional; Region: PRK02289
189423003673	active site 1 [active]
189423003674	dimer interface [polypeptide binding]; other site
189423003675	hexamer interface [polypeptide binding]; other site
189423003676	active site 2 [active]
189423003677	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
189423003678	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
189423003679	trmE is a tRNA modification GTPase; Region: trmE; cd04164
189423003680	G1 box; other site
189423003681	GTP/Mg2+ binding site [chemical binding]; other site
189423003682	Switch I region; other site
189423003683	G2 box; other site
189423003684	Switch II region; other site
189423003685	G3 box; other site
189423003686	G4 box; other site
189423003687	G5 box; other site
189423003688	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
189423003689	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
189423003690	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
189423003691	dimer interface [polypeptide binding]; other site
189423003692	active site
189423003693	catalytic residue [active]
189423003694	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
189423003695	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
189423003696	Predicted membrane protein [Function unknown]; Region: COG4708
189423003697	Predicted membrane protein [Function unknown]; Region: COG2246
189423003698	GtrA-like protein; Region: GtrA; pfam04138
189423003699	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
189423003700	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
189423003701	Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276
189423003702	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
189423003703	C-terminal domain interface [polypeptide binding]; other site
189423003704	active site
189423003705	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
189423003706	active site
189423003707	N-terminal domain interface [polypeptide binding]; other site
189423003708	peptidase T; Region: peptidase-T; TIGR01882
189423003709	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
189423003710	metal binding site [ion binding]; metal-binding site
189423003711	dimer interface [polypeptide binding]; other site
189423003712	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
189423003713	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
189423003714	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
189423003715	streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363
189423003716	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
189423003717	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
189423003718	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
189423003719	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
189423003720	streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363
189423003721	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
189423003722	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
189423003723	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
189423003724	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
189423003725	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
189423003726	metal binding site [ion binding]; metal-binding site
189423003727	amino acid transporter; Region: 2A0306; TIGR00909
189423003728	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
189423003729	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
189423003730	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
189423003731	catalytic residues [active]
189423003732	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
189423003733	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
189423003734	Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases; Region: TM_EGFR-like; cl17045
189423003735	dimer interface [polypeptide binding]; other site
189423003736	Helix-turn-helix domain; Region: HTH_28; pfam13518
189423003737	Winged helix-turn helix; Region: HTH_29; pfam13551
189423003738	Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781
189423003739	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
189423003740	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
189423003741	putative active site [active]
189423003742	catalytic site [active]
189423003743	putative metal binding site [ion binding]; other site
189423003744	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
189423003745	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
189423003746	active site
189423003747	catalytic site [active]
189423003748	substrate binding site [chemical binding]; other site
189423003749	MarR family; Region: MarR_2; cl17246
189423003750	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
189423003751	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
189423003752	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
189423003753	dimer interface [polypeptide binding]; other site
189423003754	ADP-ribose binding site [chemical binding]; other site
189423003755	active site
189423003756	nudix motif; other site
189423003757	metal binding site [ion binding]; metal-binding site
189423003758	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
189423003759	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
189423003760	Substrate binding site; other site
189423003761	Mg++ binding site; other site
189423003762	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
189423003763	active site
189423003764	substrate binding site [chemical binding]; other site
189423003765	CoA binding site [chemical binding]; other site
189423003766	Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757
189423003767	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
189423003768	active site
189423003769	Predicted membrane protein [Function unknown]; Region: COG2035
189423003770	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
189423003771	putative deacylase active site [active]
189423003772	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
189423003773	catalytic core [active]
189423003774	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
189423003775	Integrase core domain; Region: rve; pfam00665
189423003776	Integrase core domain; Region: rve_2; pfam13333
189423003777	foldase protein PrsA; Reviewed; Region: prsA; PRK01326
189423003778	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
189423003779	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
189423003780	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
189423003781	S-adenosylmethionine binding site [chemical binding]; other site
189423003782	Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164
189423003783	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
189423003784	active site
189423003785	Zn binding site [ion binding]; other site
189423003786	Competence protein CoiA-like family, contains a predicted nuclease    domain [General function prediction only]; Region: CoiA; COG4469
189423003787	tellurite resistance protein TehB; Provisional; Region: PRK12335
189423003788	Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615
189423003789	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
189423003790	S-adenosylmethionine binding site [chemical binding]; other site
189423003791	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
189423003792	SmpB-tmRNA interface; other site
189423003793	ribonuclease R; Region: RNase_R; TIGR02063
189423003794	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
189423003795	RNB domain; Region: RNB; pfam00773
189423003796	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
189423003797	RNA binding site [nucleotide binding]; other site
189423003798	Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314
189423003799	drug efflux system protein MdtG; Provisional; Region: PRK09874
189423003800	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
189423003801	putative substrate translocation pore; other site
189423003802	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
189423003803	dephospho-CoA kinase; Region: TIGR00152
189423003804	CoA-binding site [chemical binding]; other site
189423003805	ATP-binding [chemical binding]; other site
189423003806	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
189423003807	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
189423003808	DNA binding site [nucleotide binding]
189423003809	catalytic residue [active]
189423003810	H2TH interface [polypeptide binding]; other site
189423003811	putative catalytic residues [active]
189423003812	turnover-facilitating residue; other site
189423003813	intercalation triad [nucleotide binding]; other site
189423003814	8OG recognition residue [nucleotide binding]; other site
189423003815	putative reading head residues; other site
189423003816	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
189423003817	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
189423003818	GTPase Era; Reviewed; Region: era; PRK00089
189423003819	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
189423003820	G1 box; other site
189423003821	GTP/Mg2+ binding site [chemical binding]; other site
189423003822	Switch I region; other site
189423003823	G2 box; other site
189423003824	Switch II region; other site
189423003825	G3 box; other site
189423003826	G4 box; other site
189423003827	G5 box; other site
189423003828	KH domain; Region: KH_2; pfam07650
189423003829	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
189423003830	metal-binding heat shock protein; Provisional; Region: PRK00016
189423003831	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
189423003832	Domain of unknown function (DUF814); Region: DUF814; pfam05670
189423003833	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
189423003834	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
189423003835	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
189423003836	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
189423003837	heterodimer interface [polypeptide binding]; other site
189423003838	active site
189423003839	FMN binding site [chemical binding]; other site
189423003840	homodimer interface [polypeptide binding]; other site
189423003841	substrate binding site [chemical binding]; other site
189423003842	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
189423003843	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
189423003844	FAD binding pocket [chemical binding]; other site
189423003845	FAD binding motif [chemical binding]; other site
189423003846	phosphate binding motif [ion binding]; other site
189423003847	beta-alpha-beta structure motif; other site
189423003848	NAD binding pocket [chemical binding]; other site
189423003849	Iron coordination center [ion binding]; other site
189423003850	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
189423003851	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
189423003852	dimer interface [polypeptide binding]; other site
189423003853	active site
189423003854	metal binding site [ion binding]; metal-binding site
189423003855	glutathione binding site [chemical binding]; other site
189423003856	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
189423003857	23S rRNA binding site [nucleotide binding]; other site
189423003858	L21 binding site [polypeptide binding]; other site
189423003859	L13 binding site [polypeptide binding]; other site
189423003860	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
189423003861	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
189423003862	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
189423003863	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
189423003864	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
189423003865	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
189423003866	Walker A/P-loop; other site
189423003867	ATP binding site [chemical binding]; other site
189423003868	Q-loop/lid; other site
189423003869	ABC transporter signature motif; other site
189423003870	Walker B; other site
189423003871	D-loop; other site
189423003872	H-loop/switch region; other site
189423003873	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
189423003874	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
189423003875	Competence protein; Region: Competence; pfam03772
189423003876	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
189423003877	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
189423003878	SLBB domain; Region: SLBB; pfam10531
189423003879	comEA protein; Region: comE; TIGR01259
189423003880	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
189423003881	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
189423003882	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
189423003883	alanine dehydrogenase, degenerate
189423003884	Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070
189423003885	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
189423003886	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
189423003887	Coenzyme A binding pocket [chemical binding]; other site
189423003888	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
189423003889	PhoH-like protein; Region: PhoH; pfam02562
189423003890	hypothetical protein; Provisional; Region: PRK13672
189423003891	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
189423003892	S1 domain; Region: S1_2; pfam13509
189423003893	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
189423003894	ribosome recycling factor; Reviewed; Region: frr; PRK00083
189423003895	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
189423003896	hinge region; other site
189423003897	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
189423003898	putative nucleotide binding site [chemical binding]; other site
189423003899	uridine monophosphate binding site [chemical binding]; other site
189423003900	homohexameric interface [polypeptide binding]; other site
189423003901	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
189423003902	Glucose inhibited division protein A; Region: GIDA; pfam01134
189423003903	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
189423003904	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
189423003905	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
189423003906	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
189423003907	Protein of unknown function (DUF1706); Region: DUF1706; pfam08020
189423003908	Predicted methyltransferases [General function prediction only]; Region: COG0313
189423003909	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
189423003910	putative SAM binding site [chemical binding]; other site
189423003911	putative homodimer interface [polypeptide binding]; other site
189423003912	DNA replication intiation control protein YabA; Reviewed; Region: PRK13169
189423003913	DNA polymerase III subunit delta'; Validated; Region: PRK07276
189423003914	DNA polymerase III subunit delta'; Validated; Region: PRK08485
189423003915	thymidylate kinase; Validated; Region: tmk; PRK00698
189423003916	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
189423003917	TMP-binding site; other site
189423003918	ATP-binding site [chemical binding]; other site
189423003919	pyrroline-5-carboxylate reductase; Region: PLN02688
189423003920	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
189423003921	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
189423003922	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
189423003923	putative catalytic cysteine [active]
189423003924	Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263
189423003925	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
189423003926	nucleotide binding site [chemical binding]; other site
189423003927	homotetrameric interface [polypeptide binding]; other site
189423003928	putative phosphate binding site [ion binding]; other site
189423003929	putative allosteric binding site; other site
189423003930	PUA domain; Region: PUA; pfam01472
189423003931	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
189423003932	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
189423003933	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
189423003934	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
189423003935	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
189423003936	RNA binding surface [nucleotide binding]; other site
189423003937	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
189423003938	active site
189423003939	lipoprotein signal peptidase; Provisional; Region: PRK14797
189423003940	Transcriptional regulator [Transcription]; Region: LysR; COG0583
189423003941	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
189423003942	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
189423003943	dimerization interface [polypeptide binding]; other site
189423003944	CAAX protease self-immunity; Region: Abi; pfam02517
189423003945	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
189423003946	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
189423003947	active site
189423003948	motif I; other site
189423003949	motif II; other site
189423003950	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
189423003951	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
189423003952	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
189423003953	putative active site; other site
189423003954	catalytic triad [active]
189423003955	putative dimer interface [polypeptide binding]; other site
189423003956	agmatine deiminase; Provisional; Region: PRK13551
189423003957	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
189423003958	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
189423003959	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
189423003960	dimer interface [polypeptide binding]; other site
189423003961	active site
189423003962	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
189423003963	catalytic residues [active]
189423003964	substrate binding site [chemical binding]; other site
189423003965	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
189423003966	Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; pfam01488
189423003967	spermidine synthase; Provisional; Region: PRK00811
189423003968	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
189423003969	S-adenosylmethionine binding site [chemical binding]; other site
189423003970	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
189423003971	Transposase; Region: DEDD_Tnp_IS110; pfam01548
189423003972	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
189423003973	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
189423003974	homodimer interface [polypeptide binding]; other site
189423003975	pyridoxal 5'-phosphate binding site [chemical binding]; other site
189423003976	catalytic residue [active]
189423003977	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
189423003978	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
189423003979	Helix-turn-helix domain; Region: HTH_38; pfam13936
189423003980	Integrase core domain; Region: rve; pfam00665
189423003981	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
189423003982	FtsX-like permease family; Region: FtsX; pfam02687
189423003983	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
189423003984	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
189423003985	Walker A/P-loop; other site
189423003986	ATP binding site [chemical binding]; other site
189423003987	Q-loop/lid; other site
189423003988	ABC transporter signature motif; other site
189423003989	Walker B; other site
189423003990	D-loop; other site
189423003991	H-loop/switch region; other site
189423003992	Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983
189423003993	SprT homologues; Region: SprT; cl01182
189423003994	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
189423003995	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
189423003996	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
189423003997	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
189423003998	RNA binding site [nucleotide binding]; other site
189423003999	Predicted permeases [General function prediction only]; Region: COG0701
189423004000	Predicted membrane protein [Function unknown]; Region: COG3689
189423004001	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
189423004002	Domain of unknown function (DUF4300); Region: DUF4300; pfam14133
189423004003	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
189423004004	sequence-specific DNA binding site [nucleotide binding]; other site
189423004005	salt bridge; other site
189423004006	pyruvate kinase; Provisional; Region: PRK05826
189423004007	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
189423004008	domain interfaces; other site
189423004009	active site
189423004010	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
189423004011	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
189423004012	active site
189423004013	ADP/pyrophosphate binding site [chemical binding]; other site
189423004014	dimerization interface [polypeptide binding]; other site
189423004015	allosteric effector site; other site
189423004016	fructose-1,6-bisphosphate binding site; other site
189423004017	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279
189423004018	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
189423004019	active site
189423004020	PHP Thumb interface [polypeptide binding]; other site
189423004021	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
189423004022	generic binding surface II; other site
189423004023	generic binding surface I; other site
189423004024	x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371
189423004025	X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; pfam09168
189423004026	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
189423004027	Arginine repressor [Transcription]; Region: ArgR; COG1438
189423004028	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
189423004029	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
189423004030	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
189423004031	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
189423004032	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
189423004033	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
189423004034	ATP binding site [chemical binding]; other site
189423004035	putative Mg++ binding site [ion binding]; other site
189423004036	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
189423004037	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
189423004038	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
189423004039	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
189423004040	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
189423004041	active site
189423004042	catalytic residues [active]
189423004043	DNA binding site [nucleotide binding]
189423004044	Int/Topo IB signature motif; other site
189423004045	Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654
189423004046	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
189423004047	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
189423004048	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
189423004049	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
189423004050	HsdM N-terminal domain; Region: HsdM_N; pfam12161
189423004051	Methyltransferase domain; Region: Methyltransf_26; pfam13659
189423004052	carbamoylphosphate synthase large subunit, unverified frameshift
189423004053	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947
189423004054	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947
189423004055	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
189423004056	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
189423004057	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
189423004058	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
189423004059	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
189423004060	Ligand Binding Site [chemical binding]; other site
189423004061	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
189423004062	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
189423004063	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
189423004064	catalytic residue [active]
189423004065	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
189423004066	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
189423004067	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
189423004068	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
189423004069	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
189423004070	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
189423004071	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
189423004072	active site
189423004073	phosphorylation site [posttranslational modification]
189423004074	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
189423004075	active site
189423004076	P-loop; other site
189423004077	phosphorylation site [posttranslational modification]
189423004078	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
189423004079	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
189423004080	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
189423004081	putative substrate binding site [chemical binding]; other site
189423004082	putative ATP binding site [chemical binding]; other site
189423004083	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
189423004084	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
189423004085	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
189423004086	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
189423004087	Domain of unknown function DUF20; Region: UPF0118; pfam01594
189423004088	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
189423004089	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
189423004090	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
189423004091	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
189423004092	FeS assembly protein SufB; Region: sufB; TIGR01980
189423004093	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
189423004094	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
189423004095	trimerization site [polypeptide binding]; other site
189423004096	active site
189423004097	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
189423004098	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
189423004099	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
189423004100	catalytic residue [active]
189423004101	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
189423004102	FeS assembly protein SufD; Region: sufD; TIGR01981
189423004103	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
189423004104	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
189423004105	Walker A/P-loop; other site
189423004106	ATP binding site [chemical binding]; other site
189423004107	Q-loop/lid; other site
189423004108	ABC transporter signature motif; other site
189423004109	Walker B; other site
189423004110	D-loop; other site
189423004111	H-loop/switch region; other site
189423004112	Protein of unknown function (DUF3272); Region: DUF3272; pfam11676
189423004113	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
189423004114	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
189423004115	Walker A motif; other site
189423004116	ATP binding site [chemical binding]; other site
189423004117	Walker B motif; other site
189423004118	arginine finger; other site
189423004119	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
189423004120	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
189423004121	GAF domain; Region: GAF_2; pfam13185
189423004122	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
189423004123	Transposase; Region: DDE_Tnp_ISL3; pfam01610
189423004124	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
189423004125	Transposase; Region: DDE_Tnp_ISL3; pfam01610
189423004126	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
189423004127	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
189423004128	RNA binding site [nucleotide binding]; other site
189423004129	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
189423004130	RNA binding site [nucleotide binding]; other site
189423004131	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
189423004132	RNA binding site [nucleotide binding]; other site
189423004133	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
189423004134	RNA binding site [nucleotide binding]; other site
189423004135	Protein of unknown function (DUF2969); Region: DUF2969; pfam11184
189423004136	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
189423004137	putative substrate binding pocket [chemical binding]; other site
189423004138	AC domain interface; other site
189423004139	catalytic triad [active]
189423004140	AB domain interface; other site
189423004141	interchain disulfide; other site
189423004142	Predicted membrane protein [Function unknown]; Region: COG3817
189423004143	Protein of unknown function (DUF979); Region: DUF979; pfam06166
189423004144	Predicted membrane protein [Function unknown]; Region: COG3819
189423004145	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
189423004146	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
189423004147	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
189423004148	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
189423004149	homodimer interface [polypeptide binding]; other site
189423004150	substrate-cofactor binding pocket; other site
189423004151	catalytic residue [active]
189423004152	DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061
189423004153	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
189423004154	CAP-like domain; other site
189423004155	active site
189423004156	primary dimer interface [polypeptide binding]; other site
189423004157	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
189423004158	DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058
189423004159	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
189423004160	Mg2+ binding site [ion binding]; other site
189423004161	G-X-G motif; other site
189423004162	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
189423004163	anchoring element; other site
189423004164	dimer interface [polypeptide binding]; other site
189423004165	ATP binding site [chemical binding]; other site
189423004166	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
189423004167	active site
189423004168	putative metal-binding site [ion binding]; other site
189423004169	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
189423004170	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
189423004171	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
189423004172	Transposase; Region: DDE_Tnp_ISL3; pfam01610
189423004173	putative transposase OrfB; Reviewed; Region: PHA02517
189423004174	HTH-like domain; Region: HTH_21; pfam13276
189423004175	Integrase core domain; Region: rve; pfam00665
189423004176	Integrase core domain; Region: rve_2; pfam13333
189423004177	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
189423004178	Homeodomain-like domain; Region: HTH_23; cl17451
189423004179	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
189423004180	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
189423004181	TM-ABC transporter signature motif; other site
189423004182	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
189423004183	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
189423004184	TM-ABC transporter signature motif; other site
189423004185	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
189423004186	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
189423004187	Walker A/P-loop; other site
189423004188	ATP binding site [chemical binding]; other site
189423004189	Q-loop/lid; other site
189423004190	ABC transporter signature motif; other site
189423004191	Walker B; other site
189423004192	D-loop; other site
189423004193	H-loop/switch region; other site
189423004194	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
189423004195	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
189423004196	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
189423004197	ligand binding site [chemical binding]; other site
189423004198	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
189423004199	active site
189423004200	catalytic motif [active]
189423004201	Zn binding site [ion binding]; other site
189423004202	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
189423004203	intersubunit interface [polypeptide binding]; other site
189423004204	active site
189423004205	catalytic residue [active]
189423004206	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
189423004207	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
189423004208	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
189423004209	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
189423004210	Methyltransferase domain; Region: Methyltransf_31; pfam13847
189423004211	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
189423004212	S-adenosylmethionine binding site [chemical binding]; other site
189423004213	pantothenate kinase; Provisional; Region: PRK05439
189423004214	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
189423004215	ATP-binding site [chemical binding]; other site
189423004216	CoA-binding site [chemical binding]; other site
189423004217	Mg2+-binding site [ion binding]; other site
189423004218	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
189423004219	topology modulation protein; Provisional; Region: PRK07261
189423004220	AAA domain; Region: AAA_17; pfam13207
189423004221	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
189423004222	Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289
189423004223	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
189423004224	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741
189423004225	nucleophilic elbow; other site
189423004226	catalytic triad; other site
189423004227	purine nucleoside phosphorylase; Provisional; Region: PRK08202
189423004228	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797
189423004229	phosphopentomutase; Provisional; Region: PRK05362
189423004230	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
189423004231	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
189423004232	tetramer (dimer of dimers) interface [polypeptide binding]; other site
189423004233	active site
189423004234	dimer interface [polypeptide binding]; other site
189423004235	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
189423004236	putative ATP binding site [chemical binding]; other site
189423004237	putative substrate binding site [chemical binding]; other site
189423004238	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179
189423004239	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
189423004240	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
189423004241	homodimer interface [polypeptide binding]; other site
189423004242	NADP binding site [chemical binding]; other site
189423004243	substrate binding site [chemical binding]; other site
189423004244	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
189423004245	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
189423004246	Walker A/P-loop; other site
189423004247	ATP binding site [chemical binding]; other site
189423004248	Q-loop/lid; other site
189423004249	ABC transporter signature motif; other site
189423004250	Walker B; other site
189423004251	D-loop; other site
189423004252	H-loop/switch region; other site
189423004253	potential frameshift: common BLAST hit: gi|298503171|ref|YP_003725111.1| amino acid ABC superfamily transporter permease
189423004254	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
189423004255	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
189423004256	dimer interface [polypeptide binding]; other site
189423004257	conserved gate region; other site
189423004258	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703
189423004259	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
189423004260	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
189423004261	Walker A motif; other site
189423004262	ATP binding site [chemical binding]; other site
189423004263	Walker B motif; other site
189423004264	arginine finger; other site
189423004265	UvrB/uvrC motif; Region: UVR; pfam02151
189423004266	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
189423004267	Walker A motif; other site
189423004268	ATP binding site [chemical binding]; other site
189423004269	Walker B motif; other site
189423004270	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
189423004271	Helix-turn-helix domain; Region: HTH_28; pfam13518
189423004272	Winged helix-turn helix; Region: HTH_29; pfam13551
189423004273	Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684
189423004274	nudix motif; other site
189423004275	Domain of unknown function (DUF1827); Region: DUF1827; pfam08860
189423004276	Integrase core domain; Region: rve; pfam00665
189423004277	Integrase core domain; Region: rve_2; pfam13333
189423004278	HTH-like domain; Region: HTH_21; pfam13276
189423004279	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
189423004280	Homeodomain-like domain; Region: HTH_23; cl17451
189423004281	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
189423004282	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
189423004283	DDE superfamily endonuclease; Region: DDE_3; pfam13358
189423004284	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
189423004285	Winged helix-turn helix; Region: HTH_33; pfam13592
189423004286	Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477
189423004287	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
189423004288	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
189423004289	Mg2+ binding site [ion binding]; other site
189423004290	G-X-G motif; other site
189423004291	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
189423004292	anchoring element; other site
189423004293	dimer interface [polypeptide binding]; other site
189423004294	ATP binding site [chemical binding]; other site
189423004295	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
189423004296	active site
189423004297	putative metal-binding site [ion binding]; other site
189423004298	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
189423004299	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
189423004300	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
189423004301	motif II; other site
189423004302	DJ-1 family protein; Region: not_thiJ; TIGR01383
189423004303	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
189423004304	conserved cys residue [active]
189423004305	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
189423004306	bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK07246
189423004307	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
189423004308	active site
189423004309	catalytic site [active]
189423004310	substrate binding site [chemical binding]; other site
189423004311	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
189423004312	ATP binding site [chemical binding]; other site
189423004313	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
189423004314	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
189423004315	Peptidase family U32; Region: Peptidase_U32; pfam01136
189423004316	Protein of unknown function (DUF3270); Region: DUF3270; pfam11674
189423004317	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
189423004318	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
189423004319	dimer interface [polypeptide binding]; other site
189423004320	phosphorylation site [posttranslational modification]
189423004321	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
189423004322	ATP binding site [chemical binding]; other site
189423004323	Mg2+ binding site [ion binding]; other site
189423004324	G-X-G motif; other site
189423004325	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
189423004326	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
189423004327	active site
189423004328	phosphorylation site [posttranslational modification]
189423004329	intermolecular recognition site; other site
189423004330	dimerization interface [polypeptide binding]; other site
189423004331	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
189423004332	DNA binding site [nucleotide binding]
189423004333	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
189423004334	Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601
189423004335	Zn binding site [ion binding]; other site
189423004336	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
189423004337	Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574
189423004338	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
189423004339	GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746
189423004340	Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684
189423004341	nudix motif; other site
189423004342	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550
189423004343	classical (c) SDRs; Region: SDR_c; cd05233
189423004344	NAD(P) binding site [chemical binding]; other site
189423004345	active site
189423004346	Protein of unknown function (DUF2829); Region: DUF2829; pfam11195
189423004347	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
189423004348	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
189423004349	active site
189423004350	catalytic tetrad [active]
189423004351	Predicted transcriptional regulators [Transcription]; Region: COG1695
189423004352	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
189423004353	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
189423004354	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
189423004355	active site
189423004356	HIGH motif; other site
189423004357	KMSKS motif; other site
189423004358	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
189423004359	tRNA binding surface [nucleotide binding]; other site
189423004360	anticodon binding site; other site
189423004361	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
189423004362	dimer interface [polypeptide binding]; other site
189423004363	putative tRNA-binding site [nucleotide binding]; other site
189423004364	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
189423004365	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
189423004366	FtsX-like permease family; Region: FtsX; pfam02687
189423004367	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
189423004368	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
189423004369	Walker A/P-loop; other site
189423004370	ATP binding site [chemical binding]; other site
189423004371	Q-loop/lid; other site
189423004372	ABC transporter signature motif; other site
189423004373	Walker B; other site
189423004374	D-loop; other site
189423004375	H-loop/switch region; other site
189423004376	Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845
189423004377	HlyD family secretion protein; Region: HlyD_3; pfam13437
189423004378	glutathione reductase; Validated; Region: PRK06116
189423004379	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
189423004380	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
189423004381	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
189423004382	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
189423004383	Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901
189423004384	ATP cone domain; Region: ATP-cone; pfam03477
189423004385	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
189423004386	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
189423004387	RimM N-terminal domain; Region: RimM; pfam01782
189423004388	PRC-barrel domain; Region: PRC; pfam05239
189423004389	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
189423004390	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
189423004391	KH domain; Region: KH_4; pfam13083
189423004392	G-X-X-G motif; other site
189423004393	Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228
189423004394	Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652
189423004395	active site
189423004396	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
189423004397	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
189423004398	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
189423004399	ABC transporter; Region: ABC_tran_2; pfam12848
189423004400	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
189423004401	VanZ like family; Region: VanZ; pfam04892
189423004402	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454
189423004403	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470
189423004404	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
189423004405	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
189423004406	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
189423004407	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
189423004408	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
189423004409	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
189423004410	Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741
189423004411	active site
189423004412	FMN binding site [chemical binding]; other site
189423004413	substrate binding site [chemical binding]; other site
189423004414	catalytic residues [active]
189423004415	homodimer interface [polypeptide binding]; other site
189423004416	S-adenosylmethionine synthetase; Validated; Region: PRK05250
189423004417	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
189423004418	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
189423004419	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
189423004420	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
189423004421	DEAD-like helicases superfamily; Region: DEXDc; smart00487
189423004422	ATP binding site [chemical binding]; other site
189423004423	Mg++ binding site [ion binding]; other site
189423004424	motif III; other site
189423004425	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
189423004426	nucleotide binding region [chemical binding]; other site
189423004427	ATP-binding site [chemical binding]; other site
189423004428	Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079
189423004429	putative catalytic site [active]
189423004430	putative metal binding site [ion binding]; other site
189423004431	putative phosphate binding site [ion binding]; other site
189423004432	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
189423004433	PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003
189423004434	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
189423004435	active site turn [active]
189423004436	phosphorylation site [posttranslational modification]
189423004437	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
189423004438	HPr interaction site; other site
189423004439	glycerol kinase (GK) interaction site [polypeptide binding]; other site
189423004440	active site
189423004441	phosphorylation site [posttranslational modification]
189423004442	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
189423004443	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
189423004444	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
189423004445	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
189423004446	Walker A/P-loop; other site
189423004447	ATP binding site [chemical binding]; other site
189423004448	Q-loop/lid; other site
189423004449	ABC transporter signature motif; other site
189423004450	Walker B; other site
189423004451	D-loop; other site
189423004452	H-loop/switch region; other site
189423004453	peptide chain release factor 2; Region: prfB; TIGR00020
189423004454	PCRF domain; Region: PCRF; pfam03462
189423004455	RF-1 domain; Region: RF-1; pfam00472
189423004456	FOG: CBS domain [General function prediction only]; Region: COG0517
189423004457	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc2; cd04585
189423004458	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116
189423004459	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
189423004460	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
189423004461	Walker A/P-loop; other site
189423004462	ATP binding site [chemical binding]; other site
189423004463	Q-loop/lid; other site
189423004464	ABC transporter signature motif; other site
189423004465	Walker B; other site
189423004466	D-loop; other site
189423004467	H-loop/switch region; other site
189423004468	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
189423004469	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
189423004470	Walker A/P-loop; other site
189423004471	ATP binding site [chemical binding]; other site
189423004472	Q-loop/lid; other site
189423004473	ABC transporter signature motif; other site
189423004474	Walker B; other site
189423004475	D-loop; other site
189423004476	H-loop/switch region; other site
189423004477	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
189423004478	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
189423004479	TM-ABC transporter signature motif; other site
189423004480	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
189423004481	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
189423004482	TM-ABC transporter signature motif; other site
189423004483	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
189423004484	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
189423004485	putative ligand binding site [chemical binding]; other site
189423004486	hypothetical protein; Provisional; Region: PRK02302
189423004487	Clp protease; Region: CLP_protease; pfam00574
189423004488	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
189423004489	oligomer interface [polypeptide binding]; other site
189423004490	active site residues [active]
189423004491	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
189423004492	active site
189423004493	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
189423004494	catalytic motif [active]
189423004495	Zn binding site [ion binding]; other site
189423004496	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
189423004497	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
189423004498	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307
189423004499	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
189423004500	HI0933-like protein; Region: HI0933_like; pfam03486
189423004501	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
189423004502	putative active site [active]
189423004503	nucleotide binding site [chemical binding]; other site
189423004504	nudix motif; other site
189423004505	putative metal binding site [ion binding]; other site
189423004506	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
189423004507	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
189423004508	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
189423004509	gamma subunit interface [polypeptide binding]; other site
189423004510	epsilon subunit interface [polypeptide binding]; other site
189423004511	LBP interface [polypeptide binding]; other site
189423004512	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
189423004513	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
189423004514	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
189423004515	alpha subunit interaction interface [polypeptide binding]; other site
189423004516	Walker A motif; other site
189423004517	ATP binding site [chemical binding]; other site
189423004518	Walker B motif; other site
189423004519	inhibitor binding site; inhibition site
189423004520	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
189423004521	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
189423004522	core domain interface [polypeptide binding]; other site
189423004523	delta subunit interface [polypeptide binding]; other site
189423004524	epsilon subunit interface [polypeptide binding]; other site
189423004525	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
189423004526	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
189423004527	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
189423004528	beta subunit interaction interface [polypeptide binding]; other site
189423004529	Walker A motif; other site
189423004530	ATP binding site [chemical binding]; other site
189423004531	Walker B motif; other site
189423004532	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
189423004533	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
189423004534	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
189423004535	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
189423004536	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
189423004537	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
189423004538	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
189423004539	F0F1 ATP synthase subunit C; Provisional; Region: PRK13467
189423004540	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
189423004541	Integrase core domain; Region: rve; pfam00665
189423004542	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
189423004543	Helix-turn-helix domain; Region: HTH_38; pfam13936
189423004544	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
189423004545	Coenzyme A binding pocket [chemical binding]; other site
189423004546	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
189423004547	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
189423004548	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
189423004549	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
189423004550	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
189423004551	dimerization interface [polypeptide binding]; other site
189423004552	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
189423004553	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
189423004554	Coenzyme A binding pocket [chemical binding]; other site
189423004555	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
189423004556	Coenzyme A binding pocket [chemical binding]; other site
189423004557	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
189423004558	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
189423004559	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
189423004560	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
189423004561	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
189423004562	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
189423004563	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
189423004564	ATP binding site [chemical binding]; other site
189423004565	putative Mg++ binding site [ion binding]; other site
189423004566	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
189423004567	nucleotide binding region [chemical binding]; other site
189423004568	ATP-binding site [chemical binding]; other site
189423004569	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
189423004570	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
189423004571	pyridoxal 5'-phosphate binding site [chemical binding]; other site
189423004572	homodimer interface [polypeptide binding]; other site
189423004573	catalytic residue [active]
189423004574	cystathionine gamma-synthase; Reviewed; Region: PRK07269
189423004575	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
189423004576	homodimer interface [polypeptide binding]; other site
189423004577	substrate-cofactor binding pocket; other site
189423004578	pyridoxal 5'-phosphate binding site [chemical binding]; other site
189423004579	catalytic residue [active]
189423004580	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
189423004581	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
189423004582	H-loop/switch region; other site
189423004583	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
189423004584	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
189423004585	Walker A/P-loop; other site
189423004586	ATP binding site [chemical binding]; other site
189423004587	Q-loop/lid; other site
189423004588	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
189423004589	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
189423004590	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
189423004591	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
189423004592	peptide binding site [polypeptide binding]; other site
189423004593	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
189423004594	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
189423004595	UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022
189423004596	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
189423004597	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
189423004598	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
189423004599	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
189423004600	Domain of unknown function (DUF1803); Region: DUF1803; pfam08820
189423004601	Domain of unknown function (DUF1803); Region: DUF1803; pfam08820
189423004602	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
189423004603	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
189423004604	DHH family; Region: DHH; pfam01368
189423004605	DHHA2 domain; Region: DHHA2; pfam02833
189423004606	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
189423004607	GIY-YIG motif/motif A; other site
189423004608	putative active site [active]
189423004609	putative metal binding site [ion binding]; other site
189423004610	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
189423004611	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
189423004612	S-adenosylmethionine binding site [chemical binding]; other site
189423004613	hypothetical protein; Provisional; Region: PRK07252
189423004614	Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098
189423004615	RNA binding site [nucleotide binding]; other site
189423004616	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
189423004617	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
189423004618	active site
189423004619	motif I; other site
189423004620	motif II; other site
189423004621	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
189423004622	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
189423004623	active site
189423004624	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
189423004625	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
189423004626	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
189423004627	dimer interface [polypeptide binding]; other site
189423004628	ssDNA binding site [nucleotide binding]; other site
189423004629	tetramer (dimer of dimers) interface [polypeptide binding]; other site
189423004630	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
189423004631	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
189423004632	active site
189423004633	motif 3; other site
189423004634	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
189423004635	putative dimer interface [polypeptide binding]; other site
189423004636	putative anticodon binding site; other site
189423004637	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
189423004638	motif 1; other site
189423004639	dimer interface [polypeptide binding]; other site
189423004640	motif 2; other site
189423004641	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
189423004642	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
189423004643	aspartate aminotransferase; Provisional; Region: PRK05764
189423004644	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
189423004645	pyridoxal 5'-phosphate binding site [chemical binding]; other site
189423004646	homodimer interface [polypeptide binding]; other site
189423004647	catalytic residue [active]
189423004648	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353
189423004649	Predicted flavoprotein [General function prediction only]; Region: COG0431
189423004650	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
189423004651	hypothetical protein; Validated; Region: PRK02101
189423004652	Protein of unknown function (DUF3953); Region: DUF3953; pfam13129
189423004653	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
189423004654	active site
189423004655	catalytic residues [active]
189423004656	metal binding site [ion binding]; metal-binding site
189423004657	putative S-transferase; Provisional; Region: PRK11752
189423004658	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
189423004659	C-terminal domain interface [polypeptide binding]; other site
189423004660	GSH binding site (G-site) [chemical binding]; other site
189423004661	dimer interface [polypeptide binding]; other site
189423004662	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
189423004663	N-terminal domain interface [polypeptide binding]; other site
189423004664	dimer interface [polypeptide binding]; other site
189423004665	substrate binding pocket (H-site) [chemical binding]; other site
189423004666	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
189423004667	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
189423004668	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
189423004669	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
189423004670	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
189423004671	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
189423004672	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
189423004673	Cation efflux family; Region: Cation_efflux; pfam01545
189423004674	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994
189423004675	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
189423004676	Transposase; Region: DDE_Tnp_ISL3; pfam01610
189423004677	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
189423004678	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
189423004679	Walker A/P-loop; other site
189423004680	ATP binding site [chemical binding]; other site
189423004681	Q-loop/lid; other site
189423004682	ABC transporter signature motif; other site
189423004683	Walker B; other site
189423004684	D-loop; other site
189423004685	H-loop/switch region; other site
189423004686	ABC transporter; Region: ABC_tran_2; pfam12848
189423004687	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
189423004688	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
189423004689	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
189423004690	active site
189423004691	NTP binding site [chemical binding]; other site
189423004692	metal binding triad [ion binding]; metal-binding site
189423004693	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
189423004694	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
189423004695	dihydrodipicolinate reductase; Provisional; Region: PRK00048
189423004696	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
189423004697	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
189423004698	EDD domain protein, DegV family; Region: DegV; TIGR00762
189423004699	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
189423004700	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4835
189423004701	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
189423004702	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
189423004703	active site
189423004704	substrate binding site [chemical binding]; other site
189423004705	metal binding site [ion binding]; metal-binding site
189423004706	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
189423004707	YbbR-like protein; Region: YbbR; pfam07949
189423004708	Uncharacterized conserved protein [Function unknown]; Region: COG1624
189423004709	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
189423004710	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
189423004711	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
189423004712	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
189423004713	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
189423004714	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
189423004715	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
189423004716	Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044
189423004717	dimer interface [polypeptide binding]; other site
189423004718	phosphate binding site [ion binding]; other site
189423004719	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
189423004720	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
189423004721	homotrimer interaction site [polypeptide binding]; other site
189423004722	putative active site [active]
189423004723	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
189423004724	G1 box; other site
189423004725	GTP/Mg2+ binding site [chemical binding]; other site
189423004726	Switch I region; other site
189423004727	G2 box; other site
189423004728	G3 box; other site
189423004729	Switch II region; other site
189423004730	G4 box; other site
189423004731	G5 box; other site
189423004732	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
189423004733	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
189423004734	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
189423004735	Walker A motif; other site
189423004736	ATP binding site [chemical binding]; other site
189423004737	Walker B motif; other site
189423004738	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
189423004739	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
189423004740	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
189423004741	folate binding site [chemical binding]; other site
189423004742	NADP+ binding site [chemical binding]; other site
189423004743	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
189423004744	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
189423004745	dimerization interface [polypeptide binding]; other site
189423004746	DPS ferroxidase diiron center [ion binding]; other site
189423004747	ion pore; other site
189423004748	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
189423004749	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
189423004750	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
189423004751	active site
189423004752	triosephosphate isomerase; Provisional; Region: PRK14567
189423004753	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
189423004754	substrate binding site [chemical binding]; other site
189423004755	dimer interface [polypeptide binding]; other site
189423004756	catalytic triad [active]
189423004757	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
189423004758	DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446
189423004759	Homoserine trans-succinylase [Amino acid transport and metabolism]; Region: MetA; COG1897
189423004760	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
189423004761	proposed active site lysine [active]
189423004762	conserved cys residue [active]
189423004763	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
189423004764	active site
189423004765	Methyltransferase domain; Region: Methyltransf_31; pfam13847
189423004766	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
189423004767	S-adenosylmethionine binding site [chemical binding]; other site
189423004768	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
189423004769	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
189423004770	Walker A/P-loop; other site
189423004771	ATP binding site [chemical binding]; other site
189423004772	Q-loop/lid; other site
189423004773	ABC transporter signature motif; other site
189423004774	Walker B; other site
189423004775	D-loop; other site
189423004776	H-loop/switch region; other site
189423004777	TOBE domain; Region: TOBE_2; pfam08402
189423004778	Isochorismatase family; Region: Isochorismatase; pfam00857
189423004779	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
189423004780	catalytic triad [active]
189423004781	conserved cis-peptide bond; other site
189423004782	Pleiotropic transcriptional repressor [Transcription]; Region: CodY; COG4465
189423004783	CodY GAF-like domain; Region: CodY; pfam06018
189423004784	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
189423004785	putative DNA binding site [nucleotide binding]; other site
189423004786	putative Zn2+ binding site [ion binding]; other site
189423004787	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
189423004788	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
189423004789	ATP binding site [chemical binding]; other site
189423004790	Mg++ binding site [ion binding]; other site
189423004791	motif III; other site
189423004792	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
189423004793	nucleotide binding region [chemical binding]; other site
189423004794	ATP-binding site [chemical binding]; other site
189423004795	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
189423004796	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
189423004797	putative substrate translocation pore; other site
189423004798	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251
189423004799	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
189423004800	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
189423004801	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
189423004802	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
189423004803	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
189423004804	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
189423004805	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
189423004806	catalytic triad [active]
189423004807	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
189423004808	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
189423004809	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
189423004810	active site
189423004811	Integrase core domain; Region: rve; pfam00665
189423004812	Integrase core domain; Region: rve_2; pfam13333
189423004813	putative transposase OrfB; Reviewed; Region: PHA02517
189423004814	HTH-like domain; Region: HTH_21; pfam13276
189423004815	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
189423004816	Helix-turn-helix domain; Region: HTH_28; pfam13518
189423004817	Predicted membrane protein [Function unknown]; Region: COG4720
189423004818	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
189423004819	dimer interface [polypeptide binding]; other site
189423004820	substrate binding site [chemical binding]; other site
189423004821	ATP binding site [chemical binding]; other site
189423004822	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
189423004823	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
189423004824	dimerization interface 3.5A [polypeptide binding]; other site
189423004825	active site
189423004826	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
189423004827	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
189423004828	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
189423004829	PhnA protein; Region: PhnA; pfam03831
189423004830	cytidylate kinase; Provisional; Region: cmk; PRK00023
189423004831	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
189423004832	CMP-binding site; other site
189423004833	The sites determining sugar specificity; other site
189423004834	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
189423004835	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
189423004836	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
189423004837	Ligand binding site; other site
189423004838	Putative Catalytic site; other site
189423004839	DXD motif; other site
189423004840	UDP-glucose 4-epimerase; Region: PLN02240
189423004841	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
189423004842	NAD binding site [chemical binding]; other site
189423004843	homodimer interface [polypeptide binding]; other site
189423004844	active site
189423004845	substrate binding site [chemical binding]; other site
189423004846	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
189423004847	Uncharacterized conserved protein [Function unknown]; Region: COG0327
189423004848	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
189423004849	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
189423004850	Family of unknown function (DUF633); Region: DUF633; pfam04816
189423004851	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
189423004852	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
189423004853	active site
189423004854	ATP binding site [chemical binding]; other site
189423004855	putative transposase OrfB; Reviewed; Region: PHA02517
189423004856	HTH-like domain; Region: HTH_21; pfam13276
189423004857	Integrase core domain; Region: rve; pfam00665
189423004858	Integrase core domain; Region: rve_2; pfam13333
189423004859	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
189423004860	Helix-turn-helix domain; Region: HTH_28; pfam13518
189423004861	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
189423004862	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
189423004863	TPP-binding site [chemical binding]; other site
189423004864	dimer interface [polypeptide binding]; other site
189423004865	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
189423004866	PYR/PP interface [polypeptide binding]; other site
189423004867	dimer interface [polypeptide binding]; other site
189423004868	TPP binding site [chemical binding]; other site
189423004869	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
189423004870	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
189423004871	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
189423004872	substrate binding site [chemical binding]; other site
189423004873	hexamer interface [polypeptide binding]; other site
189423004874	metal binding site [ion binding]; metal-binding site
189423004875	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
189423004876	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
189423004877	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
189423004878	active site
189423004879	P-loop; other site
189423004880	phosphorylation site [posttranslational modification]
189423004881	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
189423004882	active site
189423004883	phosphorylation site [posttranslational modification]
189423004884	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
189423004885	active site
189423004886	phosphorylation site [posttranslational modification]
189423004887	HTH domain; Region: HTH_11; pfam08279
189423004888	Mga helix-turn-helix domain; Region: Mga; pfam05043
189423004889	PRD domain; Region: PRD; pfam00874
189423004890	PRD domain; Region: PRD; pfam00874
189423004891	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
189423004892	active site
189423004893	P-loop; other site
189423004894	phosphorylation site [posttranslational modification]
189423004895	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
189423004896	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
189423004897	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
189423004898	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
189423004899	motif II; other site
189423004900	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
189423004901	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
189423004902	putative acyl-acceptor binding pocket; other site
189423004903	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
189423004904	Cadmium resistance transporter; Region: Cad; pfam03596
189423004905	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
189423004906	16S/18S rRNA binding site [nucleotide binding]; other site
189423004907	S13e-L30e interaction site [polypeptide binding]; other site
189423004908	25S rRNA binding site [nucleotide binding]; other site
189423004909	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
189423004910	NADH(P)-binding; Region: NAD_binding_10; pfam13460
189423004911	NAD binding site [chemical binding]; other site
189423004912	substrate binding site [chemical binding]; other site
189423004913	putative active site [active]
189423004914	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
189423004915	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
189423004916	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
189423004917	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
189423004918	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
189423004919	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
189423004920	active site
189423004921	dimer interface [polypeptide binding]; other site
189423004922	motif 1; other site
189423004923	motif 2; other site
189423004924	motif 3; other site
189423004925	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
189423004926	anticodon binding site; other site
189423004927	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
189423004928	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
189423004929	ATP binding site [chemical binding]; other site
189423004930	Mg2+ binding site [ion binding]; other site
189423004931	G-X-G motif; other site
189423004932	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
189423004933	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
189423004934	active site
189423004935	phosphorylation site [posttranslational modification]
189423004936	intermolecular recognition site; other site
189423004937	dimerization interface [polypeptide binding]; other site
189423004938	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
189423004939	DNA binding site [nucleotide binding]
189423004940	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741
189423004941	nucleophilic elbow; other site
189423004942	catalytic triad; other site
189423004943	Predicted transcriptional regulator [Transcription]; Region: COG1959
189423004944	Transcriptional regulator; Region: Rrf2; pfam02082
189423004945	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
189423004946	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
189423004947	active site
189423004948	metal binding site [ion binding]; metal-binding site
189423004949	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
189423004950	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
189423004951	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
189423004952	FeoA domain; Region: FeoA; pfam04023
189423004953	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
189423004954	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
189423004955	putative active site [active]
189423004956	dimerization interface [polypeptide binding]; other site
189423004957	putative tRNAtyr binding site [nucleotide binding]; other site
189423004958	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
189423004959	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
189423004960	Zn2+ binding site [ion binding]; other site
189423004961	Mg2+ binding site [ion binding]; other site
189423004962	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
189423004963	synthetase active site [active]
189423004964	NTP binding site [chemical binding]; other site
189423004965	metal binding site [ion binding]; metal-binding site
189423004966	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
189423004967	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
189423004968	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
189423004969	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
189423004970	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
189423004971	active site
189423004972	Zn binding site [ion binding]; other site
189423004973	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
189423004974	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
189423004975	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
189423004976	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
189423004977	ABC-ATPase subunit  interface; other site
189423004978	dimer interface [polypeptide binding]; other site
189423004979	putative PBP binding regions; other site
189423004980	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
189423004981	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
189423004982	metal binding site [ion binding]; metal-binding site
189423004983	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
189423004984	dimer interface [polypeptide binding]; other site
189423004985	catalytic triad [active]
189423004986	peroxidatic and resolving cysteines [active]
189423004987	FtsX-like permease family; Region: FtsX; pfam02687
189423004988	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
189423004989	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
189423004990	FtsX-like permease family; Region: FtsX; pfam02687
189423004991	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
189423004992	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
189423004993	Walker A/P-loop; other site
189423004994	ATP binding site [chemical binding]; other site
189423004995	Q-loop/lid; other site
189423004996	ABC transporter signature motif; other site
189423004997	Walker B; other site
189423004998	D-loop; other site
189423004999	H-loop/switch region; other site
189423005000	alpha-fucosidase, unverified frameshift
189423005001	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
189423005002	catalytic core [active]
189423005003	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
189423005004	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
189423005005	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
189423005006	active site
189423005007	HIGH motif; other site
189423005008	nucleotide binding site [chemical binding]; other site
189423005009	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
189423005010	active site
189423005011	KMSKS motif; other site
189423005012	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
189423005013	tRNA binding surface [nucleotide binding]; other site
189423005014	anticodon binding site; other site
189423005015	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
189423005016	DivIVA domain; Region: DivI1A_domain; TIGR03544
189423005017	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
189423005018	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
189423005019	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
189423005020	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
189423005021	RNA binding surface [nucleotide binding]; other site
189423005022	YGGT family; Region: YGGT; pfam02325
189423005023	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
189423005024	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
189423005025	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
189423005026	catalytic residue [active]
189423005027	cell division protein FtsZ; Validated; Region: PRK09330
189423005028	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
189423005029	nucleotide binding site [chemical binding]; other site
189423005030	SulA interaction site; other site
189423005031	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
189423005032	Cell division protein FtsA; Region: FtsA; smart00842
189423005033	Cell division protein FtsA; Region: FtsA; pfam14450
189423005034	Domain of unknown function (DUF3484); Region: DUF3484; pfam11983
189423005035	Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529
189423005036	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
189423005037	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
189423005038	nudix motif; other site
189423005039	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
189423005040	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
189423005041	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
189423005042	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
189423005043	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
189423005044	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
189423005045	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
189423005046	recombination protein RecR; Reviewed; Region: recR; PRK00076
189423005047	RecR protein; Region: RecR; pfam02132
189423005048	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
189423005049	putative active site [active]
189423005050	putative metal-binding site [ion binding]; other site
189423005051	tetramer interface [polypeptide binding]; other site
189423005052	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
189423005053	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
189423005054	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
189423005055	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
189423005056	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
189423005057	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
189423005058	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
189423005059	putative active site [active]
189423005060	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
189423005061	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
189423005062	nucleotide binding site [chemical binding]; other site
189423005063	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
189423005064	Class I aldolases; Region: Aldolase_Class_I; cl17187
189423005065	catalytic residue [active]
189423005066	Protein of unknown function, DUF624; Region: DUF624; pfam04854
189423005067	Domain of unknown function (DUF386); Region: DUF386; pfam04074
189423005068	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
189423005069	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
189423005070	dimer interface [polypeptide binding]; other site
189423005071	conserved gate region; other site
189423005072	putative PBP binding loops; other site
189423005073	ABC-ATPase subunit interface; other site
189423005074	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
189423005075	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
189423005076	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
189423005077	putative PBP binding loops; other site
189423005078	dimer interface [polypeptide binding]; other site
189423005079	ABC-ATPase subunit interface; other site
189423005080	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
189423005081	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
189423005082	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
189423005083	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
189423005084	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
189423005085	active site turn [active]
189423005086	phosphorylation site [posttranslational modification]
189423005087	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
189423005088	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
189423005089	putative active site cavity [active]
189423005090	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
189423005091	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
189423005092	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
189423005093	Neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: NanH; COG4409
189423005094	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
189423005095	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
189423005096	Asp-box motif; other site
189423005097	catalytic site [active]
189423005098	transposase, unverified frameshift
189423005099	Sialidase, N-terminal domain; Region: Sialidase; pfam02973
189423005100	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
189423005101	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
189423005102	dimer interface [polypeptide binding]; other site
189423005103	conserved gate region; other site
189423005104	putative PBP binding loops; other site
189423005105	ABC-ATPase subunit interface; other site
189423005106	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
189423005107	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
189423005108	dimer interface [polypeptide binding]; other site
189423005109	conserved gate region; other site
189423005110	putative PBP binding loops; other site
189423005111	ABC-ATPase subunit interface; other site
189423005112	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
189423005113	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
189423005114	uncharacterized protein, YhcH/YjgK/YiaL family; Region: TIGR00022
189423005115	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
189423005116	Sialidase, N-terminal domain; Region: Sialidase; pfam02973
189423005117	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
189423005118	catalytic site [active]
189423005119	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
189423005120	Asp-box motif; other site
189423005121	Asp-box motif; other site
189423005122	catalytic site [active]
189423005123	Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448
189423005124	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
189423005125	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
189423005126	ssDNA binding site; other site
189423005127	generic binding surface II; other site
189423005128	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
189423005129	ATP binding site [chemical binding]; other site
189423005130	putative Mg++ binding site [ion binding]; other site
189423005131	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
189423005132	nucleotide binding region [chemical binding]; other site
189423005133	ATP-binding site [chemical binding]; other site
189423005134	alanine racemase; Reviewed; Region: alr; PRK00053
189423005135	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
189423005136	active site
189423005137	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
189423005138	dimer interface [polypeptide binding]; other site
189423005139	substrate binding site [chemical binding]; other site
189423005140	catalytic residues [active]
189423005141	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
189423005142	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG0722
189423005143	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
189423005144	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG0722
189423005145	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
189423005146	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
189423005147	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
189423005148	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
189423005149	nucleotide binding region [chemical binding]; other site
189423005150	ATP-binding site [chemical binding]; other site
189423005151	SEC-C motif; Region: SEC-C; pfam02810
189423005152	protein-export membrane protein SecD; Region: secD; TIGR01129
189423005153	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
189423005154	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
189423005155	Walker A/P-loop; other site
189423005156	ATP binding site [chemical binding]; other site
189423005157	Q-loop/lid; other site
189423005158	ABC transporter signature motif; other site
189423005159	Walker B; other site
189423005160	D-loop; other site
189423005161	H-loop/switch region; other site
189423005162	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
189423005163	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
189423005164	non-specific DNA binding site [nucleotide binding]; other site
189423005165	salt bridge; other site
189423005166	sequence-specific DNA binding site [nucleotide binding]; other site
189423005167	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
189423005168	GTP-binding protein Der; Reviewed; Region: PRK00093
189423005169	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
189423005170	G1 box; other site
189423005171	GTP/Mg2+ binding site [chemical binding]; other site
189423005172	Switch I region; other site
189423005173	G2 box; other site
189423005174	Switch II region; other site
189423005175	G3 box; other site
189423005176	G4 box; other site
189423005177	G5 box; other site
189423005178	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
189423005179	G1 box; other site
189423005180	GTP/Mg2+ binding site [chemical binding]; other site
189423005181	Switch I region; other site
189423005182	G2 box; other site
189423005183	G3 box; other site
189423005184	Switch II region; other site
189423005185	G4 box; other site
189423005186	G5 box; other site
189423005187	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
189423005188	dimer interface [polypeptide binding]; other site
189423005189	FMN binding site [chemical binding]; other site
189423005190	NADPH bind site [chemical binding]; other site
189423005191	primosomal protein DnaI; Reviewed; Region: PRK08939
189423005192	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
189423005193	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
189423005194	Walker A motif; other site
189423005195	ATP binding site [chemical binding]; other site
189423005196	Walker B motif; other site
189423005197	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
189423005198	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
189423005199	ATP cone domain; Region: ATP-cone; pfam03477
189423005200	Predicted transcriptional regulators [Transcription]; Region: COG1725
189423005201	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
189423005202	DNA-binding site [nucleotide binding]; DNA binding site
189423005203	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
189423005204	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
189423005205	Walker A/P-loop; other site
189423005206	ATP binding site [chemical binding]; other site
189423005207	Q-loop/lid; other site
189423005208	ABC transporter signature motif; other site
189423005209	Walker B; other site
189423005210	D-loop; other site
189423005211	H-loop/switch region; other site
189423005212	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
189423005213	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
189423005214	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
189423005215	Walker A/P-loop; other site
189423005216	ATP binding site [chemical binding]; other site
189423005217	Q-loop/lid; other site
189423005218	ABC transporter signature motif; other site
189423005219	Walker B; other site
189423005220	D-loop; other site
189423005221	H-loop/switch region; other site
189423005222	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
189423005223	Uncharacterized conserved protein [Function unknown]; Region: COG0398
189423005224	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
189423005225	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
189423005226	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
189423005227	nucleotide binding site [chemical binding]; other site
189423005228	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
189423005229	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
189423005230	active site turn [active]
189423005231	phosphorylation site [posttranslational modification]
189423005232	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
189423005233	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
189423005234	HPr interaction site; other site
189423005235	glycerol kinase (GK) interaction site [polypeptide binding]; other site
189423005236	active site
189423005237	phosphorylation site [posttranslational modification]
189423005238	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
189423005239	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
189423005240	substrate binding [chemical binding]; other site
189423005241	active site
189423005242	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
189423005243	Transcriptional regulators [Transcription]; Region: PurR; COG1609
189423005244	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
189423005245	DNA binding site [nucleotide binding]
189423005246	domain linker motif; other site
189423005247	Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291
189423005248	dimerization interface [polypeptide binding]; other site
189423005249	ligand binding site [chemical binding]; other site
189423005250	sodium binding site [ion binding]; other site
189423005251	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
189423005252	homodimer interface [polypeptide binding]; other site
189423005253	catalytic residues [active]
189423005254	NAD binding site [chemical binding]; other site
189423005255	substrate binding pocket [chemical binding]; other site
189423005256	flexible flap; other site
189423005257	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
189423005258	3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835
189423005259	dimer interface [polypeptide binding]; other site
189423005260	active site
189423005261	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
189423005262	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
189423005263	Uncharacterized conserved protein [Function unknown]; Region: COG3610
189423005264	Uncharacterized conserved protein [Function unknown]; Region: COG2966
189423005265	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
189423005266	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
189423005267	Catalytic domain of Protein Kinases; Region: PKc; cd00180
189423005268	active site
189423005269	ATP binding site [chemical binding]; other site
189423005270	substrate binding site [chemical binding]; other site
189423005271	activation loop (A-loop); other site
189423005272	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
189423005273	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
189423005274	PASTA domain; Region: PASTA; smart00740
189423005275	PASTA domain; Region: PASTA; smart00740
189423005276	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
189423005277	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
189423005278	active site
189423005279	16S rRNA methyltransferase B; Provisional; Region: PRK14902
189423005280	NusB family; Region: NusB; pfam01029
189423005281	putative RNA binding site [nucleotide binding]; other site
189423005282	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
189423005283	S-adenosylmethionine binding site [chemical binding]; other site
189423005284	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
189423005285	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
189423005286	putative active site [active]
189423005287	substrate binding site [chemical binding]; other site
189423005288	putative cosubstrate binding site; other site
189423005289	catalytic site [active]
189423005290	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
189423005291	substrate binding site [chemical binding]; other site
189423005292	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
189423005293	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
189423005294	ATP binding site [chemical binding]; other site
189423005295	putative Mg++ binding site [ion binding]; other site
189423005296	helicase superfamily c-terminal domain; Region: HELICc; smart00490
189423005297	ATP-binding site [chemical binding]; other site
189423005298	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
189423005299	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
189423005300	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
189423005301	catalytic site [active]
189423005302	G-X2-G-X-G-K; other site
189423005303	hypothetical protein; Provisional; Region: PRK00106
189423005304	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
189423005305	Zn2+ binding site [ion binding]; other site
189423005306	Mg2+ binding site [ion binding]; other site
189423005307	Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769
189423005308	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
189423005309	hypothetical protein; Provisional; Region: PRK13670
189423005310	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636
189423005311	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
189423005312	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
189423005313	S-adenosylmethionine binding site [chemical binding]; other site
189423005314	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
189423005315	Isochorismatase family; Region: Isochorismatase; pfam00857
189423005316	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
189423005317	catalytic triad [active]
189423005318	conserved cis-peptide bond; other site
189423005319	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
189423005320	Zn2+ binding site [ion binding]; other site
189423005321	Mg2+ binding site [ion binding]; other site
189423005322	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
189423005323	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
189423005324	active site
189423005325	(T/H)XGH motif; other site
189423005326	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
189423005327	GTPase YqeH; Provisional; Region: PRK13796
189423005328	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
189423005329	GTP/Mg2+ binding site [chemical binding]; other site
189423005330	G4 box; other site
189423005331	G5 box; other site
189423005332	G1 box; other site
189423005333	Switch I region; other site
189423005334	G2 box; other site
189423005335	G3 box; other site
189423005336	Switch II region; other site
189423005337	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
189423005338	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
189423005339	active site
189423005340	motif I; other site
189423005341	motif II; other site
189423005342	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
189423005343	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
189423005344	Cl binding site [ion binding]; other site
189423005345	oligomer interface [polypeptide binding]; other site
189423005346	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
189423005347	Mechanosensitive ion channel; Region: MS_channel; pfam00924
189423005348	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
189423005349	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
189423005350	Predicted membrane protein [Function unknown]; Region: COG4129
189423005351	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
189423005352	DUF939 C-terminal domain; Region: DUF939_C; pfam11728
189423005353	MarR family; Region: MarR; pfam01047
189423005354	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
189423005355	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
189423005356	catalytic residues [active]
189423005357	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
189423005358	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
189423005359	amphipathic channel; other site
189423005360	Asn-Pro-Ala signature motifs; other site
189423005361	Protein of unknown function (DUF2785); Region: DUF2785; pfam10978
189423005362	ABC-2 type transporter; Region: ABC2_membrane; cl17235
189423005363	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
189423005364	Walker A/P-loop; other site
189423005365	ATP binding site [chemical binding]; other site
189423005366	ABC transporter; Region: ABC_tran; pfam00005
189423005367	Q-loop/lid; other site
189423005368	ABC transporter signature motif; other site
189423005369	Walker B; other site
189423005370	D-loop; other site
189423005371	H-loop/switch region; other site
189423005372	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
189423005373	dimerization interface [polypeptide binding]; other site
189423005374	putative DNA binding site [nucleotide binding]; other site
189423005375	putative Zn2+ binding site [ion binding]; other site
189423005376	oligoendopeptidase F; Region: pepF; TIGR00181
189423005377	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
189423005378	Zn binding site [ion binding]; other site
189423005379	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
189423005380	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
189423005381	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
189423005382	S-adenosylmethionine binding site [chemical binding]; other site
189423005383	Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253
189423005384	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847
189423005385	Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404
189423005386	active site
189423005387	catalytic triad [active]
189423005388	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
189423005389	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
189423005390	Walker A motif; other site
189423005391	ATP binding site [chemical binding]; other site
189423005392	Walker B motif; other site
189423005393	arginine finger; other site
189423005394	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
189423005395	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
189423005396	Peptidase family M50; Region: Peptidase_M50; pfam02163
189423005397	Protein of unknown function (DUF3013); Region: DUF3013; pfam11217
189423005398	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
189423005399	YcfA-like protein; Region: YcfA; pfam07927
189423005400	recombination factor protein RarA; Reviewed; Region: PRK13342
189423005401	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
189423005402	Walker A motif; other site
189423005403	ATP binding site [chemical binding]; other site
189423005404	Walker B motif; other site
189423005405	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
189423005406	arginine finger; other site
189423005407	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
189423005408	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
189423005409	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
189423005410	substrate binding [chemical binding]; other site
189423005411	active site
189423005412	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
189423005413	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
189423005414	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
189423005415	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
189423005416	dimer interface [polypeptide binding]; other site
189423005417	conserved gate region; other site
189423005418	ABC-ATPase subunit interface; other site
189423005419	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
189423005420	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
189423005421	dimer interface [polypeptide binding]; other site
189423005422	conserved gate region; other site
189423005423	ABC-ATPase subunit interface; other site
189423005424	Transcriptional regulators [Transcription]; Region: PurR; COG1609
189423005425	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
189423005426	DNA binding site [nucleotide binding]
189423005427	domain linker motif; other site
189423005428	Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291
189423005429	dimerization interface [polypeptide binding]; other site
189423005430	ligand binding site [chemical binding]; other site
189423005431	sodium binding site [ion binding]; other site
189423005432	M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280
189423005433	Mga helix-turn-helix domain; Region: Mga; pfam05043
189423005434	M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270
189423005435	Predicted membrane protein [Function unknown]; Region: COG2261
189423005436	Small integral membrane protein [Function unknown]; Region: COG5547
189423005437	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
189423005438	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
189423005439	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
189423005440	Coenzyme A binding pocket [chemical binding]; other site
189423005441	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
189423005442	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
189423005443	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
189423005444	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
189423005445	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
189423005446	non-specific DNA binding site [nucleotide binding]; other site
189423005447	salt bridge; other site
189423005448	sequence-specific DNA binding site [nucleotide binding]; other site
189423005449	Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856
189423005450	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
189423005451	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
189423005452	substrate binding site [chemical binding]; other site
189423005453	active site
189423005454	catalytic residues [active]
189423005455	heterodimer interface [polypeptide binding]; other site
189423005456	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
189423005457	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
189423005458	pyridoxal 5'-phosphate binding site [chemical binding]; other site
189423005459	catalytic residue [active]
189423005460	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
189423005461	active site
189423005462	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
189423005463	active site
189423005464	ribulose/triose binding site [chemical binding]; other site
189423005465	phosphate binding site [ion binding]; other site
189423005466	substrate (anthranilate) binding pocket [chemical binding]; other site
189423005467	product (indole) binding pocket [chemical binding]; other site
189423005468	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
189423005469	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
189423005470	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
189423005471	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
189423005472	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
189423005473	glutamine binding [chemical binding]; other site
189423005474	catalytic triad [active]
189423005475	anthranilate synthase component I; Provisional; Region: PRK13570
189423005476	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
189423005477	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
189423005478	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
189423005479	Transcriptional regulators [Transcription]; Region: PurR; COG1609
189423005480	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
189423005481	DNA binding site [nucleotide binding]
189423005482	domain linker motif; other site
189423005483	Ligand-binding domain of a transcription repressor, FucR, which functions as a molecular sensor of L-fucose availability; Region: PBP1_FucR_like; cd06276
189423005484	putative dimerization interface [polypeptide binding]; other site
189423005485	putative ligand binding site [chemical binding]; other site
189423005486	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
189423005487	MgtC family; Region: MgtC; pfam02308
189423005488	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
189423005489	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
189423005490	dimer interface [polypeptide binding]; other site
189423005491	conserved gate region; other site
189423005492	putative PBP binding loops; other site
189423005493	ABC-ATPase subunit interface; other site
189423005494	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
189423005495	putative PBP binding loops; other site
189423005496	dimer interface [polypeptide binding]; other site
189423005497	ABC-ATPase subunit interface; other site
189423005498	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
189423005499	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
189423005500	Walker A/P-loop; other site
189423005501	ATP binding site [chemical binding]; other site
189423005502	Q-loop/lid; other site
189423005503	ABC transporter signature motif; other site
189423005504	Walker B; other site
189423005505	D-loop; other site
189423005506	H-loop/switch region; other site
189423005507	TOBE domain; Region: TOBE; pfam03459
189423005508	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
189423005509	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
189423005510	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5255
189423005511	Domain of unknown function (DUF1868); Region: 2H-phosphodiest; pfam08975
189423005512	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
189423005513	UDP-glucose 4-epimerase; Region: PLN02240
189423005514	NAD binding site [chemical binding]; other site
189423005515	homodimer interface [polypeptide binding]; other site
189423005516	active site
189423005517	substrate binding site [chemical binding]; other site
189423005518	Galactose-1-phosphate uridyltransferase [Carbohydrate transport and metabolism]; Region: GalT; COG4468
189423005519	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
189423005520	Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744
189423005521	Phosphate uptake regulator [Inorganic ion transport and metabolism]; Region: PhoU; COG0704
189423005522	PhoU domain; Region: PhoU; pfam01895
189423005523	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
189423005524	YSIRK type signal peptide; Region: YSIRK_signal; cl04650
189423005525	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
189423005526	Pectate lyase; Region: Pec_lyase_C; cl01593
189423005527	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
189423005528	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
189423005529	inhibitor-cofactor binding pocket; inhibition site
189423005530	pyridoxal 5'-phosphate binding site [chemical binding]; other site
189423005531	catalytic residue [active]
189423005532	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
189423005533	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
189423005534	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
189423005535	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
189423005536	Walker A/P-loop; other site
189423005537	ATP binding site [chemical binding]; other site
189423005538	Q-loop/lid; other site
189423005539	ABC transporter signature motif; other site
189423005540	Walker B; other site
189423005541	D-loop; other site
189423005542	H-loop/switch region; other site
189423005543	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
189423005544	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
189423005545	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
189423005546	Walker A/P-loop; other site
189423005547	ATP binding site [chemical binding]; other site
189423005548	Q-loop/lid; other site
189423005549	ABC transporter signature motif; other site
189423005550	Walker B; other site
189423005551	D-loop; other site
189423005552	H-loop/switch region; other site
189423005553	Predicted membrane protein [Function unknown]; Region: COG2323
189423005554	Protein of unknown function (DUF3290); Region: DUF3290; pfam11694
189423005555	Protein of unknown function (DUF3290); Region: DUF3290; pfam11694
189423005556	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
189423005557	active site
189423005558	putative catalytic site [active]
189423005559	DNA binding site [nucleotide binding]
189423005560	putative phosphate binding site [ion binding]; other site
189423005561	metal binding site A [ion binding]; metal-binding site
189423005562	AP binding site [nucleotide binding]; other site
189423005563	metal binding site B [ion binding]; metal-binding site
189423005564	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
189423005565	dimer interface [polypeptide binding]; other site
189423005566	ligand binding site [chemical binding]; other site
189423005567	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
189423005568	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
189423005569	active site
189423005570	xanthine permease; Region: pbuX; TIGR03173
189423005571	Sulfate transporter family; Region: Sulfate_transp; pfam00916
189423005572	DpnII restriction endonuclease; Region: DpnII; pfam04556
189423005573	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
189423005574	DNA methylase; Region: N6_N4_Mtase; pfam01555
189423005575	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
189423005576	S-adenosylmethionine binding site [chemical binding]; other site
189423005577	DNA adenine methylase (dam); Region: dam; TIGR00571
189423005578	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
189423005579	CoenzymeA binding site [chemical binding]; other site
189423005580	subunit interaction site [polypeptide binding]; other site
189423005581	PHB binding site; other site
189423005582	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270
189423005583	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
189423005584	Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744
189423005585	galactokinase; Provisional; Region: PRK05322
189423005586	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
189423005587	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
189423005588	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
189423005589	DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339
189423005590	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
189423005591	DNA binding site [nucleotide binding]
189423005592	Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544
189423005593	putative dimerization interface [polypeptide binding]; other site
189423005594	putative ligand binding site [chemical binding]; other site
189423005595	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287
189423005596	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
189423005597	catalytic Zn binding site [ion binding]; other site
189423005598	NAD(P) binding site [chemical binding]; other site
189423005599	structural Zn binding site [ion binding]; other site
189423005600	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
189423005601	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
189423005602	DNA binding residues [nucleotide binding]
189423005603	putative dimer interface [polypeptide binding]; other site
189423005604	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
189423005605	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
189423005606	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
189423005607	Utp21 specific WD40 associated putative domain; Region: Utp21; pfam04192
189423005608	nicotinamide mononucleotide transporter PnuC; Region: NMN_trans_PnuC; TIGR01528
189423005609	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
189423005610	dimer interface [polypeptide binding]; other site
189423005611	conserved gate region; other site
189423005612	ABC-ATPase subunit interface; other site
189423005613	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
189423005614	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
189423005615	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
189423005616	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
189423005617	Walker A/P-loop; other site
189423005618	ATP binding site [chemical binding]; other site
189423005619	Q-loop/lid; other site
189423005620	ABC transporter signature motif; other site
189423005621	Walker B; other site
189423005622	D-loop; other site
189423005623	H-loop/switch region; other site
189423005624	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
189423005625	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
189423005626	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
189423005627	Enterocin A Immunity; Region: EntA_Immun; pfam08951
189423005628	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
189423005629	M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638
189423005630	oligomer interface [polypeptide binding]; other site
189423005631	active site
189423005632	metal binding site [ion binding]; metal-binding site
189423005633	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
189423005634	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
189423005635	NAD(P) binding site [chemical binding]; other site
189423005636	active site
189423005637	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
189423005638	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
189423005639	ABC-ATPase subunit  interface; other site
189423005640	dimer interface [polypeptide binding]; other site
189423005641	putative PBP binding regions; other site
189423005642	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
189423005643	ABC-ATPase subunit  interface; other site
189423005644	dimer interface [polypeptide binding]; other site
189423005645	putative PBP binding regions; other site
189423005646	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
189423005647	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
189423005648	Walker A/P-loop; other site
189423005649	ATP binding site [chemical binding]; other site
189423005650	Q-loop/lid; other site
189423005651	ABC transporter signature motif; other site
189423005652	Walker B; other site
189423005653	D-loop; other site
189423005654	H-loop/switch region; other site
189423005655	ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607
189423005656	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
189423005657	putative ligand binding residues [chemical binding]; other site
189423005658	hypothetical protein; Validated; Region: PRK00041
189423005659	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
189423005660	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
189423005661	RNA binding surface [nucleotide binding]; other site
189423005662	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
189423005663	active site
189423005664	segregation and condensation protein B; Reviewed; Region: scpB; PRK00135
189423005665	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
189423005666	site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436
189423005667	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
189423005668	DNA binding site [nucleotide binding]
189423005669	Int/Topo IB signature motif; other site
189423005670	active site
189423005671	catalytic residues [active]
189423005672	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643
189423005673	FOG: CBS domain [General function prediction only]; Region: COG0517
189423005674	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
189423005675	active site
189423005676	metal binding site [ion binding]; metal-binding site
189423005677	homotetramer interface [polypeptide binding]; other site
189423005678	putative deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein; Reviewed; Region: PRK02491
189423005679	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
189423005680	active site
189423005681	dimerization interface [polypeptide binding]; other site
189423005682	glutamate racemase; Provisional; Region: PRK00865
189423005683	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763
189423005684	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
189423005685	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
189423005686	Ca binding site [ion binding]; other site
189423005687	active site
189423005688	catalytic site [active]
189423005689	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
189423005690	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
189423005691	active site turn [active]
189423005692	phosphorylation site [posttranslational modification]
189423005693	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
189423005694	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
189423005695	HPr interaction site; other site
189423005696	glycerol kinase (GK) interaction site [polypeptide binding]; other site
189423005697	active site
189423005698	phosphorylation site [posttranslational modification]
189423005699	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
189423005700	DNA-binding site [nucleotide binding]; DNA binding site
189423005701	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
189423005702	UTRA domain; Region: UTRA; pfam07702
189423005703	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
189423005704	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
189423005705	Transposase; Region: DDE_Tnp_ISL3; pfam01610
189423005706	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
189423005707	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
189423005708	Walker A/P-loop; other site
189423005709	ATP binding site [chemical binding]; other site
189423005710	Q-loop/lid; other site
189423005711	ABC transporter signature motif; other site
189423005712	Walker B; other site
189423005713	D-loop; other site
189423005714	H-loop/switch region; other site
189423005715	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
189423005716	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
189423005717	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
189423005718	Walker A/P-loop; other site
189423005719	ATP binding site [chemical binding]; other site
189423005720	Q-loop/lid; other site
189423005721	ABC transporter signature motif; other site
189423005722	Walker B; other site
189423005723	D-loop; other site
189423005724	H-loop/switch region; other site
189423005725	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
189423005726	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
189423005727	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
189423005728	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
189423005729	dimer interface [polypeptide binding]; other site
189423005730	conserved gate region; other site
189423005731	putative PBP binding loops; other site
189423005732	ABC-ATPase subunit interface; other site
189423005733	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
189423005734	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
189423005735	dimer interface [polypeptide binding]; other site
189423005736	conserved gate region; other site
189423005737	putative PBP binding loops; other site
189423005738	ABC-ATPase subunit interface; other site
189423005739	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
189423005740	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
189423005741	peptide binding site [polypeptide binding]; other site
189423005742	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
189423005743	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
189423005744	sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852
189423005745	Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355
189423005746	active site
189423005747	homodimer interface [polypeptide binding]; other site
189423005748	catalytic site [active]
189423005749	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
189423005750	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
189423005751	dimer interface [polypeptide binding]; other site
189423005752	conserved gate region; other site
189423005753	putative PBP binding loops; other site
189423005754	ABC-ATPase subunit interface; other site
189423005755	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
189423005756	dimer interface [polypeptide binding]; other site
189423005757	conserved gate region; other site
189423005758	putative PBP binding loops; other site
189423005759	ABC-ATPase subunit interface; other site
189423005760	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
189423005761	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
189423005762	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
189423005763	Melibiase; Region: Melibiase; pfam02065
189423005764	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
189423005765	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
189423005766	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
189423005767	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
189423005768	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
189423005769	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
189423005770	DNA-binding site [nucleotide binding]; DNA binding site
189423005771	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
189423005772	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
189423005773	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
189423005774	TRAM domain; Region: TRAM; cl01282
189423005775	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
189423005776	S-adenosylmethionine binding site [chemical binding]; other site
189423005777	recombination regulator RecX; Provisional; Region: recX; PRK14135
189423005778	hypothetical protein; Provisional; Region: PRK13662
189423005779	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
189423005780	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
189423005781	non-specific DNA binding site [nucleotide binding]; other site
189423005782	salt bridge; other site
189423005783	sequence-specific DNA binding site [nucleotide binding]; other site
189423005784	Methyltransferase domain; Region: Methyltransf_31; pfam13847
189423005785	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
189423005786	S-adenosylmethionine binding site [chemical binding]; other site
189423005787	Uncharacterized BCR, COG1636; Region: DUF208; cl17782
189423005788	Uncharacterized BCR, COG1636; Region: DUF208; cl17782
189423005789	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
189423005790	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
189423005791	ring oligomerisation interface [polypeptide binding]; other site
189423005792	ATP/Mg binding site [chemical binding]; other site
189423005793	stacking interactions; other site
189423005794	hinge regions; other site
189423005795	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
189423005796	oligomerisation interface [polypeptide binding]; other site
189423005797	mobile loop; other site
189423005798	roof hairpin; other site
189423005799	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
189423005800	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
189423005801	dimer interface [polypeptide binding]; other site
189423005802	ssDNA binding site [nucleotide binding]; other site
189423005803	tetramer (dimer of dimers) interface [polypeptide binding]; other site
189423005804	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
189423005805	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
189423005806	putative NAD(P) binding site [chemical binding]; other site
189423005807	homodimer interface [polypeptide binding]; other site
189423005808	homotetramer interface [polypeptide binding]; other site
189423005809	active site
189423005810	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
189423005811	putative tRNA-binding site [nucleotide binding]; other site
189423005812	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
189423005813	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
189423005814	catalytic residues [active]
189423005815	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
189423005816	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
189423005817	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
189423005818	LytTr DNA-binding domain; Region: LytTR; smart00850
189423005819	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
189423005820	active site
189423005821	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4898
189423005822	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
189423005823	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
189423005824	Walker A/P-loop; other site
189423005825	ATP binding site [chemical binding]; other site
189423005826	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
189423005827	Walker A/P-loop; other site
189423005828	ATP binding site [chemical binding]; other site
189423005829	Q-loop/lid; other site
189423005830	ABC transporter signature motif; other site
189423005831	Walker B; other site
189423005832	D-loop; other site
189423005833	H-loop/switch region; other site
189423005834	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
189423005835	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
189423005836	MarR family; Region: MarR_2; pfam12802
189423005837	Transcriptional regulators [Transcription]; Region: MarR; COG1846
189423005838	hypothetical protein; Provisional; Region: PRK12378
189423005839	Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289
189423005840	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108
189423005841	Protein of unknown function (DUF4231); Region: DUF4231; pfam14015
189423005842	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
189423005843	Glycerophosphodiester phosphodiesterase domain of Agrobacterium tumefaciens and similar proteins; Region: GDPD_AtGDE_like; cd08566
189423005844	putative active site [active]
189423005845	catalytic site [active]
189423005846	putative metal binding site [ion binding]; other site
189423005847	oligomer interface [polypeptide binding]; other site
189423005848	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
189423005849	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
189423005850	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
189423005851	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
189423005852	Walker A/P-loop; other site
189423005853	ATP binding site [chemical binding]; other site
189423005854	Q-loop/lid; other site
189423005855	ABC transporter signature motif; other site
189423005856	Walker B; other site
189423005857	D-loop; other site
189423005858	H-loop/switch region; other site
189423005859	TOBE domain; Region: TOBE_2; pfam08402
189423005860	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
189423005861	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
189423005862	dimer interface [polypeptide binding]; other site
189423005863	conserved gate region; other site
189423005864	putative PBP binding loops; other site
189423005865	ABC-ATPase subunit interface; other site
189423005866	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
189423005867	dimer interface [polypeptide binding]; other site
189423005868	conserved gate region; other site
189423005869	putative PBP binding loops; other site
189423005870	ABC-ATPase subunit interface; other site
189423005871	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
189423005872	MgtC family; Region: MgtC; pfam02308
189423005873	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
189423005874	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
189423005875	motif II; other site
189423005876	Transcriptional regulators [Transcription]; Region: PurR; COG1609
189423005877	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
189423005878	DNA binding site [nucleotide binding]
189423005879	domain linker motif; other site
189423005880	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
189423005881	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
189423005882	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
189423005883	Domain of unknown function (DUF955); Region: DUF955; cl01076
189423005884	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
189423005885	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
189423005886	non-specific DNA binding site [nucleotide binding]; other site
189423005887	salt bridge; other site
189423005888	sequence-specific DNA binding site [nucleotide binding]; other site
189423005889	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
189423005890	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
189423005891	amidase catalytic site [active]
189423005892	Zn binding residues [ion binding]; other site
189423005893	substrate binding site [chemical binding]; other site
189423005894	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
189423005895	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
189423005896	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
189423005897	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
189423005898	recombinase A; Provisional; Region: recA; PRK09354
189423005899	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
189423005900	hexamer interface [polypeptide binding]; other site
189423005901	Walker A motif; other site
189423005902	ATP binding site [chemical binding]; other site
189423005903	Walker B motif; other site
189423005904	competence damage-inducible protein A; Provisional; Region: PRK00549
189423005905	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
189423005906	putative MPT binding site; other site
189423005907	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
189423005908	Transcriptional regulator [Transcription]; Region: LytR; COG1316
189423005909	putative acetyltransferase YhhY; Provisional; Region: PRK10140
189423005910	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
189423005911	Coenzyme A binding pocket [chemical binding]; other site
189423005912	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
189423005913	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
189423005914	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
189423005915	non-specific DNA binding site [nucleotide binding]; other site
189423005916	salt bridge; other site
189423005917	sequence-specific DNA binding site [nucleotide binding]; other site
189423005918	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652
189423005919	Protein of unknown function (DUF1430); Region: DUF1430; pfam07242
189423005920	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
189423005921	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
189423005922	Walker A/P-loop; other site
189423005923	ATP binding site [chemical binding]; other site
189423005924	Q-loop/lid; other site
189423005925	ABC transporter signature motif; other site
189423005926	Walker B; other site
189423005927	D-loop; other site
189423005928	H-loop/switch region; other site
189423005929	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
189423005930	active site
189423005931	multimer interface [polypeptide binding]; other site
189423005932	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
189423005933	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
189423005934	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
189423005935	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
189423005936	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
189423005937	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
189423005938	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
189423005939	G-loop; other site
189423005940	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
189423005941	DNA binding site [nucleotide binding]
189423005942	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
189423005943	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
189423005944	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
189423005945	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
189423005946	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
189423005947	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
189423005948	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
189423005949	RPB1 interaction site [polypeptide binding]; other site
189423005950	RPB10 interaction site [polypeptide binding]; other site
189423005951	RPB11 interaction site [polypeptide binding]; other site
189423005952	RPB3 interaction site [polypeptide binding]; other site
189423005953	RPB12 interaction site [polypeptide binding]; other site
189423005954	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
189423005955	Domain of unknown function DUF21; Region: DUF21; pfam01595
189423005956	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
189423005957	Transporter associated domain; Region: CorC_HlyC; smart01091
189423005958	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
189423005959	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; pfam01223
189423005960	DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772
189423005961	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
189423005962	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
189423005963	hinge; other site
189423005964	active site
189423005965	Protein of unknown function (DUF1146); Region: DUF1146; pfam06612
189423005966	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
189423005967	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
189423005968	protein binding site [polypeptide binding]; other site
189423005969	Phosphopantetheine adenylyltransferase [Coenzyme metabolism]; Region: CoaD; COG0669
189423005970	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
189423005971	active site
189423005972	(T/H)XGH motif; other site
189423005973	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
189423005974	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
189423005975	S-adenosylmethionine binding site [chemical binding]; other site
189423005976	Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia.  AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645
189423005977	dimer interface [polypeptide binding]; other site
189423005978	active site
189423005979	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
189423005980	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
189423005981	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
189423005982	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
189423005983	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
189423005984	acylphosphatase; Provisional; Region: PRK14434
189423005985	OxaA-like protein precursor; Provisional; Region: PRK02463
189423005986	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
189423005987	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
189423005988	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
189423005989	FeS/SAM binding site; other site
189423005990	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
189423005991	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
189423005992	active site
189423005993	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
189423005994	substrate binding site [chemical binding]; other site
189423005995	catalytic residues [active]
189423005996	dimer interface [polypeptide binding]; other site
189423005997	pur operon repressor; Provisional; Region: PRK09213
189423005998	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
189423005999	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
189423006000	active site
189423006001	Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481
189423006002	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
189423006003	generic binding surface II; other site
189423006004	generic binding surface I; other site
189423006005	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
189423006006	Zn2+ binding site [ion binding]; other site
189423006007	Mg2+ binding site [ion binding]; other site
189423006008	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
189423006009	RmuC family; Region: RmuC; pfam02646
189423006010	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
189423006011	Thiamine pyrophosphokinase; Region: TPK; cd07995
189423006012	active site
189423006013	dimerization interface [polypeptide binding]; other site
189423006014	thiamine binding site [chemical binding]; other site
189423006015	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
189423006016	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
189423006017	substrate binding site [chemical binding]; other site
189423006018	hexamer interface [polypeptide binding]; other site
189423006019	metal binding site [ion binding]; metal-binding site
189423006020	GTPase RsgA; Reviewed; Region: PRK00098
189423006021	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
189423006022	RNA binding site [nucleotide binding]; other site
189423006023	homodimer interface [polypeptide binding]; other site
189423006024	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
189423006025	GTPase/Zn-binding domain interface [polypeptide binding]; other site
189423006026	GTP/Mg2+ binding site [chemical binding]; other site
189423006027	G4 box; other site
189423006028	G5 box; other site
189423006029	G1 box; other site
189423006030	Switch I region; other site
189423006031	G2 box; other site
189423006032	G3 box; other site
189423006033	Switch II region; other site
189423006034	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
189423006035	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
189423006036	S-adenosylmethionine binding site [chemical binding]; other site
189423006037	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
189423006038	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
189423006039	Walker A/P-loop; other site
189423006040	ATP binding site [chemical binding]; other site
189423006041	Q-loop/lid; other site
189423006042	ABC transporter signature motif; other site
189423006043	Walker B; other site
189423006044	D-loop; other site
189423006045	H-loop/switch region; other site
189423006046	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652
189423006047	Protein of unknown function (DUF1430); Region: DUF1430; pfam07242
189423006048	Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891
189423006049	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
189423006050	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
189423006051	non-specific DNA binding site [nucleotide binding]; other site
189423006052	salt bridge; other site
189423006053	sequence-specific DNA binding site [nucleotide binding]; other site
189423006054	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
189423006055	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
189423006056	putative active site [active]
189423006057	putative metal binding site [ion binding]; other site
189423006058	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
189423006059	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
189423006060	active site
189423006061	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
189423006062	Ribosomal protein L34; Region: Ribosomal_L34; cl00370
189423006063	aminotransferase AlaT; Validated; Region: PRK09265
189423006064	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
189423006065	pyridoxal 5'-phosphate binding site [chemical binding]; other site
189423006066	homodimer interface [polypeptide binding]; other site
189423006067	catalytic residue [active]
189423006068	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
189423006069	Ligand Binding Site [chemical binding]; other site
189423006070	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
189423006071	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
189423006072	active site
189423006073	motif I; other site
189423006074	motif II; other site
189423006075	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
189423006076	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545
189423006077	putative nucleotide binding site [chemical binding]; other site
189423006078	putative metal binding site [ion binding]; other site
189423006079	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
189423006080	active site
189423006081	homotetramer interface [polypeptide binding]; other site
189423006082	homodimer interface [polypeptide binding]; other site
189423006083	catabolite control protein A; Region: ccpA; TIGR01481
189423006084	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
189423006085	DNA binding site [nucleotide binding]
189423006086	domain linker motif; other site
189423006087	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
189423006088	dimerization interface [polypeptide binding]; other site
189423006089	effector binding site; other site
189423006090	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
189423006091	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
189423006092	active site
189423006093	phosphorylation site [posttranslational modification]
189423006094	intermolecular recognition site; other site
189423006095	dimerization interface [polypeptide binding]; other site
189423006096	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
189423006097	DNA binding residues [nucleotide binding]
189423006098	dimerization interface [polypeptide binding]; other site
189423006099	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
189423006100	Histidine kinase; Region: HisKA_3; pfam07730
189423006101	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
189423006102	Mg2+ binding site [ion binding]; other site
189423006103	G-X-G motif; other site
189423006104	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
189423006105	ABC-2 type transporter; Region: ABC2_membrane; cl17235
189423006106	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
189423006107	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
189423006108	Walker A/P-loop; other site
189423006109	ATP binding site [chemical binding]; other site
189423006110	Q-loop/lid; other site
189423006111	ABC transporter signature motif; other site
189423006112	Walker B; other site
189423006113	D-loop; other site
189423006114	H-loop/switch region; other site
189423006115	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
189423006116	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
189423006117	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
189423006118	putative homodimer interface [polypeptide binding]; other site
189423006119	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
189423006120	heterodimer interface [polypeptide binding]; other site
189423006121	homodimer interface [polypeptide binding]; other site
189423006122	Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690
189423006123	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
189423006124	Transglycosylase; Region: Transgly; pfam00912
189423006125	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
189423006126	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
189423006127	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
189423006128	active site
189423006129	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
189423006130	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
189423006131	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
189423006132	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
189423006133	FtsX-like permease family; Region: FtsX; pfam02687
189423006134	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
189423006135	DDE superfamily endonuclease; Region: DDE_3; pfam13358
189423006136	Helix-turn-helix domain; Region: HTH_28; pfam13518
189423006137	Winged helix-turn helix; Region: HTH_29; pfam13551
189423006138	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06559
189423006139	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
189423006140	dimerization interface [polypeptide binding]; other site
189423006141	active site
189423006142	Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158
189423006143	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
189423006144	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
189423006145	Walker A/P-loop; other site
189423006146	ATP binding site [chemical binding]; other site
189423006147	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
189423006148	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
189423006149	DNA-binding site [nucleotide binding]; DNA binding site
189423006150	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
189423006151	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
189423006152	beta-galactosidase; Region: BGL; TIGR03356
189423006153	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
189423006154	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
189423006155	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
189423006156	active site
189423006157	P-loop; other site
189423006158	phosphorylation site [posttranslational modification]
189423006159	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
189423006160	methionine cluster; other site
189423006161	active site
189423006162	phosphorylation site [posttranslational modification]
189423006163	metal binding site [ion binding]; metal-binding site
189423006164	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
189423006165	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
189423006166	putative catalytic cysteine [active]
189423006167	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
189423006168	putative active site [active]
189423006169	metal binding site [ion binding]; metal-binding site
189423006170	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
189423006171	MORN repeat; Region: MORN; cl14787
189423006172	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
189423006173	Low molecular weight phosphatase family; Region: LMWPc; cd00115
189423006174	active site
189423006175	preprotein translocase subunit YajC; Validated; Region: yajC; PRK06531
189423006176	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
189423006177	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
189423006178	TPP-binding site [chemical binding]; other site
189423006179	dimer interface [polypeptide binding]; other site
189423006180	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
189423006181	PYR/PP interface [polypeptide binding]; other site
189423006182	dimer interface [polypeptide binding]; other site
189423006183	TPP binding site [chemical binding]; other site
189423006184	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
189423006185	putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709
189423006186	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
189423006187	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
189423006188	PRD domain; Region: PRD; pfam00874
189423006189	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
189423006190	active site
189423006191	P-loop; other site
189423006192	phosphorylation site [posttranslational modification]
189423006193	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
189423006194	L-ribulose-5-phosphate 4-epimerase; Provisional; Region: araD; PRK13145
189423006195	intersubunit interface [polypeptide binding]; other site
189423006196	active site
189423006197	Zn2+ binding site [ion binding]; other site
189423006198	putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210
189423006199	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
189423006200	AP (apurinic/apyrimidinic) site pocket; other site
189423006201	DNA interaction; other site
189423006202	Metal-binding active site; metal-binding site
189423006203	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
189423006204	active site
189423006205	dimer interface [polypeptide binding]; other site
189423006206	magnesium binding site [ion binding]; other site
189423006207	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
189423006208	active site
189423006209	phosphorylation site [posttranslational modification]
189423006210	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
189423006211	active site
189423006212	P-loop; other site
189423006213	phosphorylation site [posttranslational modification]
189423006214	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997
189423006215	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
189423006216	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
189423006217	G-X-X-G motif; other site
189423006218	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
189423006219	RxxxH motif; other site
189423006220	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
189423006221	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
189423006222	ribonuclease P; Reviewed; Region: rnpA; PRK00499
189423006223	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
189423006224	propionate/acetate kinase; Provisional; Region: PRK12379
189423006225	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
189423006226	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
189423006227	S-adenosylmethionine binding site [chemical binding]; other site
189423006228	potential frameshift: common BLAST hit: gi|225855535|ref|YP_002737047.1| methyltransferase small domain superfamily
189423006229	Methyltransferase domain; Region: Methyltransf_12; pfam08242
189423006230	Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940
189423006231	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
189423006232	Type II secretory pathway pseudopilin; Region: PulG; pfam11773
189423006233	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
189423006234	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
189423006235	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
189423006236	amidase catalytic site [active]
189423006237	Zn binding residues [ion binding]; other site
189423006238	substrate binding site [chemical binding]; other site
189423006239	Phage holin protein (Holin_LLH); Region: Holin_LLH; pfam09682
189423006240	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
189423006241	Phage-related protein [Function unknown]; Region: COG5412
189423006242	Phage tail protein; Region: Phage_tail_3; pfam08813
189423006243	Protein of unknown function (DUF3168); Region: DUF3168; pfam11367
189423006244	Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124
189423006245	Domain of unknown function (DUF4355); Region: DUF4355; pfam14265
189423006246	HD domain; Region: HD_4; pfam13328
189423006247	Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072
189423006248	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
189423006249	metal binding triad [ion binding]; metal-binding site
189423006250	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
189423006251	phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538
189423006252	Phage terminase large subunit; Region: Terminase_3; cl12054
189423006253	Terminase-like family; Region: Terminase_6; pfam03237
189423006254	Terminase small subunit; Region: Terminase_2; pfam03592
189423006255	Protein of unknown function (DUF1492); Region: DUF1492; pfam07374
189423006256	YopX protein; Region: YopX; cl09859
189423006257	Protein of unknown function (DUF1642); Region: DUF1642; pfam07852
189423006258	Endodeoxyribonuclease RusA; Region: RusA; pfam05866
189423006259	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
189423006260	S-adenosylmethionine binding site [chemical binding]; other site
189423006261	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
189423006262	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
189423006263	dimer interface [polypeptide binding]; other site
189423006264	ssDNA binding site [nucleotide binding]; other site
189423006265	tetramer (dimer of dimers) interface [polypeptide binding]; other site
189423006266	Protein of unknown function (DUF1351); Region: DUF1351; pfam07083
189423006267	RecT family; Region: RecT; pfam03837
189423006268	Phage anti-repressor protein [Transcription]; Region: COG3561
189423006269	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
189423006270	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
189423006271	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
189423006272	non-specific DNA binding site [nucleotide binding]; other site
189423006273	salt bridge; other site
189423006274	sequence-specific DNA binding site [nucleotide binding]; other site
189423006275	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
189423006276	non-specific DNA binding site [nucleotide binding]; other site
189423006277	salt bridge; other site
189423006278	sequence-specific DNA binding site [nucleotide binding]; other site
189423006279	Predicted transcriptional regulator [Transcription]; Region: COG2932
189423006280	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
189423006281	Catalytic site [active]
189423006282	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
189423006283	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
189423006284	catalytic residues [active]
189423006285	catalytic nucleophile [active]
189423006286	Presynaptic Site I dimer interface [polypeptide binding]; other site
189423006287	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
189423006288	Synaptic Flat tetramer interface [polypeptide binding]; other site
189423006289	Synaptic Site I dimer interface [polypeptide binding]; other site
189423006290	DNA binding site [nucleotide binding]
189423006291	Recombinase; Region: Recombinase; pfam07508
189423006292	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
189423006293	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
189423006294	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
189423006295	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
189423006296	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
189423006297	Walker A motif; other site
189423006298	ATP binding site [chemical binding]; other site
189423006299	Walker B motif; other site
189423006300	Protein of unknown function (DUF1033); Region: DUF1033; pfam06279
189423006301	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286
189423006302	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
189423006303	catalytic Zn binding site [ion binding]; other site
189423006304	structural Zn binding site [ion binding]; other site
189423006305	NAD(P) binding site [chemical binding]; other site
189423006306	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
189423006307	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
189423006308	active site
189423006309	dimer interface [polypeptide binding]; other site
189423006310	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
189423006311	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
189423006312	catalytic triad [active]
189423006313	catalytic triad [active]
189423006314	oxyanion hole [active]
189423006315	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
189423006316	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
189423006317	Predicted integral membrane protein [Function unknown]; Region: COG5523
189423006318	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
189423006319	putative substrate binding pocket [chemical binding]; other site
189423006320	AC domain interface; other site
189423006321	catalytic triad [active]
189423006322	AB domain interface; other site
189423006323	interchain disulfide; other site
189423006324	Predicted membrane protein [Function unknown]; Region: COG3759
189423006325	Transcriptional regulators [Transcription]; Region: MarR; COG1846
189423006326	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
189423006327	putative DNA binding site [nucleotide binding]; other site
189423006328	putative Zn2+ binding site [ion binding]; other site
189423006329	potential frameshift: common BLAST hit: gi|225859821|ref|YP_002741331.1| LysM domain-containing protein
189423006330	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
189423006331	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
189423006332	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
189423006333	motif II; other site
189423006334	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
189423006335	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
189423006336	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
189423006337	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
189423006338	pyridoxal 5'-phosphate binding site [chemical binding]; other site
189423006339	catalytic residue [active]
189423006340	Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572
189423006341	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
189423006342	active site
189423006343	catalytic motif [active]
189423006344	Zn binding site [ion binding]; other site
189423006345	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
189423006346	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
189423006347	active site
189423006348	HIGH motif; other site
189423006349	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
189423006350	active site
189423006351	KMSKS motif; other site
189423006352	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
189423006353	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
189423006354	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
189423006355	active site
189423006356	dimer interface [polypeptide binding]; other site
189423006357	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
189423006358	dimer interface [polypeptide binding]; other site
189423006359	active site
189423006360	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
189423006361	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
189423006362	catalytic triad [active]
189423006363	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
189423006364	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
189423006365	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
189423006366	Walker A/P-loop; other site
189423006367	ATP binding site [chemical binding]; other site
189423006368	Q-loop/lid; other site
189423006369	ABC transporter signature motif; other site
189423006370	Walker B; other site
189423006371	D-loop; other site
189423006372	H-loop/switch region; other site
189423006373	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
189423006374	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
189423006375	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
189423006376	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
189423006377	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
189423006378	Walker A/P-loop; other site
189423006379	ATP binding site [chemical binding]; other site
189423006380	Q-loop/lid; other site
189423006381	ABC transporter signature motif; other site
189423006382	Walker B; other site
189423006383	D-loop; other site
189423006384	H-loop/switch region; other site
189423006385	DNA mismatch repair protein MutS; Region: mutS1; TIGR01070
189423006386	MutS domain I; Region: MutS_I; pfam01624
189423006387	MutS domain II; Region: MutS_II; pfam05188
189423006388	MutS domain III; Region: MutS_III; pfam05192
189423006389	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
189423006390	Walker A/P-loop; other site
189423006391	ATP binding site [chemical binding]; other site
189423006392	Q-loop/lid; other site
189423006393	ABC transporter signature motif; other site
189423006394	Walker B; other site
189423006395	D-loop; other site
189423006396	H-loop/switch region; other site
189423006397	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
189423006398	arginine repressor; Region: argR_whole; TIGR01529
189423006399	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
189423006400	arginyl-tRNA synthetase; Reviewed; Region: PRK12451
189423006401	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
189423006402	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
189423006403	active site
189423006404	HIGH motif; other site
189423006405	KMSK motif region; other site
189423006406	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
189423006407	tRNA binding surface [nucleotide binding]; other site
189423006408	anticodon binding site; other site
189423006409	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
189423006410	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
189423006411	Uncharacterized conserved protein [Function unknown]; Region: COG3542
189423006412	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
189423006413	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
189423006414	active site
189423006415	phosphorylation site [posttranslational modification]
189423006416	intermolecular recognition site; other site
189423006417	dimerization interface [polypeptide binding]; other site
189423006418	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
189423006419	DNA binding site [nucleotide binding]
189423006420	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
189423006421	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
189423006422	dimer interface [polypeptide binding]; other site
189423006423	phosphorylation site [posttranslational modification]
189423006424	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
189423006425	ATP binding site [chemical binding]; other site
189423006426	G-X-G motif; other site
189423006427	PBP superfamily domain; Region: PBP_like_2; cl17296
189423006428	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
189423006429	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
189423006430	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
189423006431	dimer interface [polypeptide binding]; other site
189423006432	conserved gate region; other site
189423006433	putative PBP binding loops; other site
189423006434	ABC-ATPase subunit interface; other site
189423006435	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
189423006436	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
189423006437	dimer interface [polypeptide binding]; other site
189423006438	conserved gate region; other site
189423006439	putative PBP binding loops; other site
189423006440	ABC-ATPase subunit interface; other site
189423006441	phosphate transporter ATP-binding protein; Provisional; Region: PRK14240
189423006442	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
189423006443	Walker A/P-loop; other site
189423006444	ATP binding site [chemical binding]; other site
189423006445	Q-loop/lid; other site
189423006446	ABC transporter signature motif; other site
189423006447	Walker B; other site
189423006448	D-loop; other site
189423006449	H-loop/switch region; other site
189423006450	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
189423006451	PhoU domain; Region: PhoU; pfam01895
189423006452	PhoU domain; Region: PhoU; pfam01895
189423006453	DNA replication terminus site-binding protein (Ter protein); Region: Ter; cl11502
189423006454	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
189423006455	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
189423006456	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
189423006457	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
189423006458	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
189423006459	active site
189423006460	tetramer interface; other site
189423006461	Rhomboid family; Region: Rhomboid; pfam01694
189423006462	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
189423006463	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
189423006464	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
189423006465	M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670
189423006466	metal binding site [ion binding]; metal-binding site
189423006467	putative dimer interface [polypeptide binding]; other site
189423006468	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
189423006469	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
189423006470	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
189423006471	trimer interface [polypeptide binding]; other site
189423006472	active site
189423006473	substrate binding site [chemical binding]; other site
189423006474	CoA binding site [chemical binding]; other site
189423006475	putative membrane protein, unverified frameshift
189423006476	Transglycosylase; Region: Transgly; pfam00912
189423006477	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
189423006478	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
189423006479	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
189423006480	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
189423006481	active site
189423006482	HIGH motif; other site
189423006483	dimer interface [polypeptide binding]; other site
189423006484	KMSKS motif; other site
189423006485	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
189423006486	RNA binding surface [nucleotide binding]; other site
189423006487	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
189423006488	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
189423006489	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
189423006490	motif II; other site
189423006491	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
189423006492	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
189423006493	S-adenosylmethionine binding site [chemical binding]; other site
189423006494	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
189423006495	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
189423006496	4-alpha-glucanotransferase; Provisional; Region: PRK14508
189423006497	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
189423006498	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
189423006499	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
189423006500	dimer interface [polypeptide binding]; other site
189423006501	conserved gate region; other site
189423006502	putative PBP binding loops; other site
189423006503	ABC-ATPase subunit interface; other site
189423006504	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
189423006505	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
189423006506	dimer interface [polypeptide binding]; other site
189423006507	conserved gate region; other site
189423006508	putative PBP binding loops; other site
189423006509	ABC-ATPase subunit interface; other site
189423006510	Predicted integral membrane protein [Function unknown]; Region: COG5521
189423006511	Transcriptional regulators [Transcription]; Region: PurR; COG1609
189423006512	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
189423006513	DNA binding site [nucleotide binding]
189423006514	domain linker motif; other site
189423006515	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
189423006516	putative dimerization interface [polypeptide binding]; other site
189423006517	putative ligand binding site [chemical binding]; other site
189423006518	Uncharacterized conserved protein [Function unknown]; Region: COG1284
189423006519	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
189423006520	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
189423006521	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
189423006522	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
189423006523	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
189423006524	dimer interface [polypeptide binding]; other site
189423006525	anticodon binding site; other site
189423006526	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
189423006527	homodimer interface [polypeptide binding]; other site
189423006528	motif 1; other site
189423006529	active site
189423006530	motif 2; other site
189423006531	GAD domain; Region: GAD; pfam02938
189423006532	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
189423006533	motif 3; other site
189423006534	CAAX protease self-immunity; Region: Abi; pfam02517
189423006535	Protein of unknown function (DUF3169); Region: DUF3169; pfam11368
189423006536	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
189423006537	non-specific DNA binding site [nucleotide binding]; other site
189423006538	salt bridge; other site
189423006539	sequence-specific DNA binding site [nucleotide binding]; other site
189423006540	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
189423006541	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
189423006542	dimer interface [polypeptide binding]; other site
189423006543	motif 1; other site
189423006544	active site
189423006545	motif 2; other site
189423006546	motif 3; other site
189423006547	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
189423006548	anticodon binding site; other site
189423006549	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
189423006550	non-specific DNA binding site [nucleotide binding]; other site
189423006551	salt bridge; other site
189423006552	sequence-specific DNA binding site [nucleotide binding]; other site
189423006553	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
189423006554	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
189423006555	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
189423006556	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
189423006557	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
189423006558	PYR/PP interface [polypeptide binding]; other site
189423006559	dimer interface [polypeptide binding]; other site
189423006560	TPP binding site [chemical binding]; other site
189423006561	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
189423006562	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
189423006563	TPP-binding site [chemical binding]; other site
189423006564	dimer interface [polypeptide binding]; other site
189423006565	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
189423006566	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
189423006567	active site
189423006568	P-loop; other site
189423006569	phosphorylation site [posttranslational modification]
189423006570	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
189423006571	PRD domain; Region: PRD; pfam00874
189423006572	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
189423006573	active site
189423006574	P-loop; other site
189423006575	phosphorylation site [posttranslational modification]
189423006576	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
189423006577	active site
189423006578	phosphorylation site [posttranslational modification]
189423006579	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
189423006580	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_2; cd03402
189423006581	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877
189423006582	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
189423006583	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
189423006584	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
189423006585	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
189423006586	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
189423006587	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
189423006588	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
189423006589	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
189423006590	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
189423006591	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
189423006592	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
189423006593	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
189423006594	Divergent AAA domain; Region: AAA_4; pfam04326
189423006595	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
189423006596	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
189423006597	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
189423006598	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
189423006599	Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA  is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565
189423006600	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
189423006601	putative active site [active]
189423006602	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
189423006603	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
189423006604	nucleotide binding site [chemical binding]; other site
189423006605	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
189423006606	N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814
189423006607	active site
189423006608	metal binding site [ion binding]; metal-binding site
189423006609	homodimer interface [polypeptide binding]; other site
189423006610	catalytic site [active]
189423006611	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
189423006612	Uncharacterized conserved protein [Function unknown]; Region: COG3538
189423006613	Protein of unknown function (DUF1237); Region: DUF1237; pfam06824
189423006614	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
189423006615	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
189423006616	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
189423006617	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
189423006618	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
189423006619	arginine deiminase; Provisional; Region: PRK01388
189423006620	ornithine carbamoyltransferase; Validated; Region: PRK02102
189423006621	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
189423006622	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
189423006623	carbamate kinase; Reviewed; Region: PRK12686
189423006624	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
189423006625	putative substrate binding site [chemical binding]; other site
189423006626	nucleotide binding site [chemical binding]; other site
189423006627	nucleotide binding site [chemical binding]; other site
189423006628	homodimer interface [polypeptide binding]; other site
189423006629	Predicted membrane protein [Function unknown]; Region: COG1288
189423006630	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
189423006631	hypothetical protein; Provisional; Region: PRK07205
189423006632	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
189423006633	active site
189423006634	metal binding site [ion binding]; metal-binding site
189423006635	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
189423006636	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
189423006637	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_4; cd03407
189423006638	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
189423006639	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
189423006640	dimer interface [polypeptide binding]; other site
189423006641	active site
189423006642	metal binding site [ion binding]; metal-binding site
189423006643	L-fucose isomerase; Provisional; Region: fucI; PRK10991
189423006644	L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556
189423006645	hexamer (dimer of trimers) interface [polypeptide binding]; other site
189423006646	trimer interface [polypeptide binding]; other site
189423006647	substrate binding site [chemical binding]; other site
189423006648	Mn binding site [ion binding]; other site
189423006649	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
189423006650	intersubunit interface [polypeptide binding]; other site
189423006651	active site
189423006652	Zn2+ binding site [ion binding]; other site
189423006653	NPCBM/NEW2 domain; Region: NPCBM; pfam08305
189423006654	NPCBM/NEW2 domain; Region: NPCBM; pfam08305
189423006655	Glycosyl hydrolase family 98; Region: Glyco_hydro_98M; pfam08306
189423006656	Glycosyl hydrolase family 98 C-terminal domain; Region: Glyco_hydro_98C; pfam08307
189423006657	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
189423006658	Melibiase; Region: Melibiase; pfam02065
189423006659	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
189423006660	Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812
189423006661	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
189423006662	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
189423006663	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
189423006664	dimer interface [polypeptide binding]; other site
189423006665	conserved gate region; other site
189423006666	putative PBP binding loops; other site
189423006667	ABC-ATPase subunit interface; other site
189423006668	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
189423006669	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
189423006670	dimer interface [polypeptide binding]; other site
189423006671	conserved gate region; other site
189423006672	putative PBP binding loops; other site
189423006673	ABC-ATPase subunit interface; other site
189423006674	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
189423006675	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
189423006676	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
189423006677	N- and C-terminal domain interface [polypeptide binding]; other site
189423006678	rhamnulokinase; Region: rhamnulo_kin; TIGR02627
189423006679	active site
189423006680	putative catalytic site [active]
189423006681	metal binding site [ion binding]; metal-binding site
189423006682	ATP binding site [chemical binding]; other site
189423006683	carbohydrate binding site [chemical binding]; other site
189423006684	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
189423006685	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
189423006686	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
189423006687	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
189423006688	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
189423006689	metal binding site [ion binding]; metal-binding site
189423006690	YodA lipocalin-like domain; Region: YodA; pfam09223
189423006691	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
189423006692	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
189423006693	ABC-ATPase subunit  interface; other site
189423006694	dimer interface [polypeptide binding]; other site
189423006695	putative PBP binding regions; other site
189423006696	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
189423006697	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
189423006698	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
189423006699	putative DNA binding site [nucleotide binding]; other site
189423006700	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966
189423006701	DltD N-terminal region; Region: DltD_N; pfam04915
189423006702	DltD central region; Region: DltD_M; pfam04918
189423006703	DltD C-terminal region; Region: DltD_C; pfam04914
189423006704	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087
189423006705	D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091
189423006706	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
189423006707	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
189423006708	acyl-activating enzyme (AAE) consensus motif; other site
189423006709	AMP binding site [chemical binding]; other site
189423006710	potential frameshift: common BLAST hit: gi|225857746|ref|YP_002739257.1| permease of the major facilitator superfamily
189423006711	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
189423006712	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
189423006713	putative active site [active]
189423006714	putative NTP binding site [chemical binding]; other site
189423006715	putative nucleic acid binding site [nucleotide binding]; other site
189423006716	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
189423006717	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
189423006718	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
189423006719	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
189423006720	amphipathic channel; other site
189423006721	Asn-Pro-Ala signature motifs; other site
189423006722	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
189423006723	glycerol kinase; Provisional; Region: glpK; PRK00047
189423006724	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
189423006725	N- and C-terminal domain interface [polypeptide binding]; other site
189423006726	active site
189423006727	MgATP binding site [chemical binding]; other site
189423006728	catalytic site [active]
189423006729	metal binding site [ion binding]; metal-binding site
189423006730	glycerol binding site [chemical binding]; other site
189423006731	homotetramer interface [polypeptide binding]; other site
189423006732	homodimer interface [polypeptide binding]; other site
189423006733	FBP binding site [chemical binding]; other site
189423006734	protein IIAGlc interface [polypeptide binding]; other site
189423006735	Mga helix-turn-helix domain; Region: Mga; pfam05043
189423006736	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
189423006737	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
189423006738	dimerization interface [polypeptide binding]; other site
189423006739	domain crossover interface; other site
189423006740	redox-dependent activation switch; other site
189423006741	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
189423006742	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
189423006743	FMN binding site [chemical binding]; other site
189423006744	active site
189423006745	catalytic residues [active]
189423006746	substrate binding site [chemical binding]; other site
189423006747	RICH domain; Region: RICH; pfam05062
189423006748	RICH domain; Region: RICH; pfam05062
189423006749	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
189423006750	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
189423006751	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
189423006752	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
189423006753	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
189423006754	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
189423006755	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
189423006756	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
189423006757	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755
189423006758	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
189423006759	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
189423006760	dimerization interface [polypeptide binding]; other site
189423006761	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
189423006762	dimer interface [polypeptide binding]; other site
189423006763	phosphorylation site [posttranslational modification]
189423006764	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
189423006765	ATP binding site [chemical binding]; other site
189423006766	Mg2+ binding site [ion binding]; other site
189423006767	G-X-G motif; other site
189423006768	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
189423006769	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
189423006770	active site
189423006771	phosphorylation site [posttranslational modification]
189423006772	intermolecular recognition site; other site
189423006773	dimerization interface [polypeptide binding]; other site
189423006774	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
189423006775	DNA binding site [nucleotide binding]
189423006776	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
189423006777	Clp amino terminal domain; Region: Clp_N; pfam02861
189423006778	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
189423006779	Walker A motif; other site
189423006780	ATP binding site [chemical binding]; other site
189423006781	Walker B motif; other site
189423006782	arginine finger; other site
189423006783	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
189423006784	Walker A motif; other site
189423006785	ATP binding site [chemical binding]; other site
189423006786	Walker B motif; other site
189423006787	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
189423006788	Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463
189423006789	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
189423006790	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
189423006791	Walker A/P-loop; other site
189423006792	ATP binding site [chemical binding]; other site
189423006793	Q-loop/lid; other site
189423006794	ABC transporter signature motif; other site
189423006795	Walker B; other site
189423006796	D-loop; other site
189423006797	H-loop/switch region; other site
189423006798	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
189423006799	NMT1/THI5 like; Region: NMT1; pfam09084
189423006800	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
189423006801	Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528
189423006802	Uncharacterized conserved protein [Function unknown]; Region: COG0011
189423006803	Surface antigen [General function prediction only]; Region: COG3942
189423006804	CHAP domain; Region: CHAP; pfam05257
189423006805	Bacterial SH3 domain; Region: SH3_5; pfam08460
189423006806	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
189423006807	Bacterial SH3 domain; Region: SH3_5; pfam08460
189423006808	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
189423006809	Uncharacterized protein conserved in bacteria [Function unknown]; Region: Veg; COG4466
189423006810	replicative DNA helicase; Provisional; Region: PRK05748
189423006811	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
189423006812	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
189423006813	Walker A motif; other site
189423006814	ATP binding site [chemical binding]; other site
189423006815	Walker B motif; other site
189423006816	DNA binding loops [nucleotide binding]
189423006817	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
189423006818	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
189423006819	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
189423006820	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
189423006821	DHH family; Region: DHH; pfam01368
189423006822	DHHA1 domain; Region: DHHA1; pfam02272
189423006823	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
189423006824	30S subunit binding site; other site
189423006825	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
189423006826	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
189423006827	active site
189423006828	Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098
189423006829	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
189423006830	ATP binding site [chemical binding]; other site
189423006831	putative Mg++ binding site [ion binding]; other site
189423006832	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
189423006833	nucleotide binding region [chemical binding]; other site
189423006834	ATP-binding site [chemical binding]; other site
189423006835	Uncharacterized conserved protein [Function unknown]; Region: COG1739
189423006836	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
189423006837	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
189423006838	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
189423006839	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
189423006840	dimer interface [polypeptide binding]; other site
189423006841	pyridoxal 5'-phosphate binding site [chemical binding]; other site
189423006842	catalytic residue [active]
189423006843	elongation factor Ts; Provisional; Region: tsf; PRK09377
189423006844	UBA/TS-N domain; Region: UBA; pfam00627
189423006845	Elongation factor TS; Region: EF_TS; pfam00889
189423006846	Elongation factor TS; Region: EF_TS; pfam00889
189423006847	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
189423006848	rRNA interaction site [nucleotide binding]; other site
189423006849	S8 interaction site; other site
189423006850	putative laminin-1 binding site; other site
189423006851	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
189423006852	Septum formation initiator; Region: DivIC; cl17659
189423006853	Surface antigen [General function prediction only]; Region: COG3942
189423006854	CHAP domain; Region: CHAP; pfam05257
189423006855	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891
189423006856	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792
189423006857	rod shape-determining protein MreC; Region: MreC; pfam04085
189423006858	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
189423006859	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13649
189423006860	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
189423006861	Walker A/P-loop; other site
189423006862	ATP binding site [chemical binding]; other site
189423006863	Q-loop/lid; other site
189423006864	ABC transporter signature motif; other site
189423006865	Walker B; other site
189423006866	D-loop; other site
189423006867	H-loop/switch region; other site
189423006868	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13650
189423006869	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
189423006870	Walker A/P-loop; other site
189423006871	ATP binding site [chemical binding]; other site
189423006872	Q-loop/lid; other site
189423006873	ABC transporter signature motif; other site
189423006874	Walker B; other site
189423006875	D-loop; other site
189423006876	H-loop/switch region; other site
189423006877	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
189423006878	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
189423006879	Helix-turn-helix domain; Region: HTH_25; pfam13413
189423006880	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
189423006881	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
189423006882	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
189423006883	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
189423006884	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
189423006885	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
189423006886	S4-like RNA binding protein [Replication, recombination, and repair]; Region: COG2501
189423006887	Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195
189423006888	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
189423006889	Walker A/P-loop; other site
189423006890	ATP binding site [chemical binding]; other site
189423006891	Q-loop/lid; other site
189423006892	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
189423006893	ABC transporter signature motif; other site
189423006894	Walker B; other site
189423006895	D-loop; other site
189423006896	H-loop/switch region; other site
189423006897	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
189423006898	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
189423006899	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
189423006900	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
189423006901	active site
189423006902	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
189423006903	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
189423006904	active site
189423006905	HIGH motif; other site
189423006906	dimer interface [polypeptide binding]; other site
189423006907	KMSKS motif; other site
189423006908	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
189423006909	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
189423006910	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
189423006911	ABC transporter; Region: ABC_tran_2; pfam12848
189423006912	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
189423006913	Predicted membrane protein [Function unknown]; Region: COG4485
189423006914	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
189423006915	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
189423006916	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
189423006917	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
189423006918	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
189423006919	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
189423006920	active site
189423006921	phosphorylation site [posttranslational modification]
189423006922	intermolecular recognition site; other site
189423006923	dimerization interface [polypeptide binding]; other site
189423006924	LytTr DNA-binding domain; Region: LytTR; pfam04397
189423006925	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
189423006926	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
189423006927	COMC family; Region: ComC; pfam03047
189423006928	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
189423006929	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
189423006930	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
189423006931	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
189423006932	protein binding site [polypeptide binding]; other site
189423006933	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
189423006934	ParB-like nuclease domain; Region: ParBc; pfam02195
189423006935	KorB domain; Region: KorB; pfam08535