-- dump date 20140620_083922 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GI -- field 3 GeneID -- field 4 chrom_position -- field 5 chromosome -- field 6 codon_start -- field 7 contig -- field 8 description -- field 9 end_pos -- field 10 gene -- field 11 gene_id -- field 12 name -- field 13 organism -- field 14 product -- field 15 protein_id -- field 16 start_pos -- field 17 strand -- field 18 taxid -- field 19 type -- header -- id GI GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type YP_002739320.1 225857810 7683930 197..1558 1 NC_012468.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 1558 dnaA 7683930 dnaA Streptococcus pneumoniae 70585 chromosomal replication initiation protein YP_002739320.1 197 D 488221 CDS YP_002739321.1 225857811 7684330 1717..2853 1 NC_012468.1 binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 2853 dnaN 7684330 dnaN Streptococcus pneumoniae 70585 DNA polymerase III subunit beta YP_002739321.1 1717 D 488221 CDS YP_002739322.1 225857812 7683974 2918..3112 1 NC_012468.1 identified by match to protein family HMM PF06107; hypothetical protein 3112 7683974 SP70585_0003 Streptococcus pneumoniae 70585 hypothetical protein YP_002739322.1 2918 D 488221 CDS YP_002739323.1 225857813 7684147 3196..4311 1 NC_012468.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 4311 ychF 7684147 ychF Streptococcus pneumoniae 70585 GTP-dependent nucleic acid-binding protein EngD YP_002739323.1 3196 D 488221 CDS YP_002739324.1 225857814 7683332 4382..4951 1 NC_012468.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 4951 pth 7683332 pth Streptococcus pneumoniae 70585 peptidyl-tRNA hydrolase YP_002739324.1 4382 D 488221 CDS YP_002739325.1 225857815 7684228 4952..8461 1 NC_012468.1 identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM PF02559; match to protein family HMM PF03461; match to protein family HMM PF04851; match to protein family HMM TIGR00580; transcription-repair coupling factor 8461 mfd 7684228 mfd Streptococcus pneumoniae 70585 transcription-repair coupling factor YP_002739325.1 4952 D 488221 CDS YP_002739326.1 225857816 7683441 8519..8785 1 NC_012468.1 identified by match to protein family HMM PF01479; ribosome-associated heat shock protein implicated in the recycling of the 50S subunit 8785 7683441 SP70585_0007 Streptococcus pneumoniae 70585 ribosome-associated heat shock protein implicated in the recycling of the 50S subunit YP_002739326.1 8519 D 488221 CDS YP_002739327.1 225857817 7683651 8778..9146 1 NC_012468.1 identified by match to protein family HMM PF04977; septum formation initiator 9146 7683651 SP70585_0008 Streptococcus pneumoniae 70585 septum formation initiator YP_002739327.1 8778 D 488221 CDS YP_002739328.1 225857818 7684830 9151..9273 1 NC_012468.1 hypothetical protein 9273 7684830 SP70585_0009 Streptococcus pneumoniae 70585 hypothetical protein YP_002739328.1 9151 D 488221 CDS YP_002739329.1 225857819 7683109 9266..10534 1 NC_012468.1 beta-lactamase class A 10534 7683109 SP70585_0010 Streptococcus pneumoniae 70585 beta-lactamase class A YP_002739329.1 9266 D 488221 CDS YP_002739330.1 225857820 7684646 10531..11808 1 NC_012468.1 identified by match to protein family HMM PF01171; match to protein family HMM TIGR02432; match to protein family HMM TIGR02433; tRNA(Ile)-lysidine synthase (tRNA(Ile)-lysidinesynthetase) (tRNA(Ile)-2-lysyl-cytidine synthase) 11808 7684646 SP70585_0011 Streptococcus pneumoniae 70585 tRNA(Ile)-lysidine synthase (tRNA(Ile)-lysidinesynthetase) (tRNA(Ile)-2-lysyl-cytidine synthase) YP_002739330.1 10531 D 488221 CDS YP_002739331.1 225857821 7684919 11812..12354 1 NC_012468.1 identified by match to protein family HMM PF00156; match to protein family HMM TIGR01203; hypoxanthine phosphoribosyltransferase 12354 hpt 7684919 hpt Streptococcus pneumoniae 70585 hypoxanthine phosphoribosyltransferase YP_002739331.1 11812 D 488221 CDS YP_002739332.1 225857822 7682999 12370..14328 1 NC_012468.1 identified by match to protein family HMM PF00004; match to protein family HMM PF01434; match to protein family HMM PF06480; match to protein family HMM TIGR01241; ATP-dependent metallopeptidase HflB 14328 hflB 7682999 hflB Streptococcus pneumoniae 70585 ATP-dependent metallopeptidase HflB YP_002739332.1 12370 D 488221 CDS YP_002739333.1 225857823 7683672 complement(14392..15648) 1 NC_012468.1 identified by match to protein family HMM PF01610; transposase 15648 7683672 SP70585_0014 Streptococcus pneumoniae 70585 transposase YP_002739333.1 14392 R 488221 CDS YP_002739334.1 225857824 7684454 15872..16351 1 NC_012468.1 competence-specific global transcription modulator 16351 7684454 SP70585_0015 Streptococcus pneumoniae 70585 competence-specific global transcription modulator YP_002739334.1 15872 D 488221 CDS YP_002739335.1 225857825 7683905 21928..22110 1 NC_012468.1 transposase 22110 7683905 SP70585_0023 Streptococcus pneumoniae 70585 transposase YP_002739335.1 21928 D 488221 CDS YP_002739336.1 225857826 7683514 complement(22187..22330) 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase 22330 7683514 SP70585_0024 Streptococcus pneumoniae 70585 transposase YP_002739336.1 22187 R 488221 CDS YP_002739337.1 225857827 7683085 complement(22378..22584) 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase 22584 7683085 SP70585_0025 Streptococcus pneumoniae 70585 transposase YP_002739337.1 22378 R 488221 CDS YP_002739338.1 225857828 7684649 22901..23137 1 NC_012468.1 hypothetical protein 23137 7684649 SP70585_0026 Streptococcus pneumoniae 70585 hypothetical protein YP_002739338.1 22901 D 488221 CDS YP_002739339.1 225857829 7684942 23326..24654 1 NC_012468.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 24654 purA 7684942 purA Streptococcus pneumoniae 70585 adenylosuccinate synthetase YP_002739339.1 23326 D 488221 CDS YP_002739340.1 225857830 7684051 complement(24896..26044) 1 NC_012468.1 identified by match to protein family HMM PF00589; integrase 26044 7684051 SP70585_0028 Streptococcus pneumoniae 70585 integrase YP_002739340.1 24896 R 488221 CDS YP_002739341.1 225857831 7684638 complement(26216..27130) 1 NC_012468.1 identified by match to protein family HMM PF08797; phage protein 27130 7684638 SP70585_0029 Streptococcus pneumoniae 70585 phage protein YP_002739341.1 26216 R 488221 CDS YP_002739342.1 225857832 7683119 complement(27142..27525) 1 NC_012468.1 identified by match to protein family HMM PF06114; hypothetical protein 27525 7683119 SP70585_0030 Streptococcus pneumoniae 70585 hypothetical protein YP_002739342.1 27142 R 488221 CDS YP_002739343.1 225857833 7683273 complement(27538..27903) 1 NC_012468.1 identified by match to protein family HMM PF01381; phage transcriptional regulator, Cro/CI family 27903 7683273 SP70585_0031 Streptococcus pneumoniae 70585 phage transcriptional regulator, Cro/CI family YP_002739343.1 27538 R 488221 CDS YP_002739344.1 225857834 7684762 28189..28335 1 NC_012468.1 hypothetical protein 28335 7684762 SP70585_0032 Streptococcus pneumoniae 70585 hypothetical protein YP_002739344.1 28189 D 488221 CDS YP_002739345.1 225857835 7683301 28328..28531 1 NC_012468.1 hypothetical protein 28531 7683301 SP70585_0033 Streptococcus pneumoniae 70585 hypothetical protein YP_002739345.1 28328 D 488221 CDS YP_002739346.1 225857836 7684111 28543..28677 1 NC_012468.1 hypothetical protein 28677 7684111 SP70585_0034 Streptococcus pneumoniae 70585 hypothetical protein YP_002739346.1 28543 D 488221 CDS YP_002739347.1 225857837 7685026 28674..29387 1 NC_012468.1 identified by match to protein family HMM PF02498; gp15 29387 7685026 SP70585_0035 Streptococcus pneumoniae 70585 gp15 YP_002739347.1 28674 D 488221 CDS YP_002739348.1 225857838 7684835 29399..29656 1 NC_012468.1 phage protein 29656 7684835 SP70585_0036 Streptococcus pneumoniae 70585 phage protein YP_002739348.1 29399 D 488221 CDS YP_002739349.1 225857839 7683095 29742..30062 1 NC_012468.1 hypothetical protein 30062 7683095 SP70585_0037 Streptococcus pneumoniae 70585 hypothetical protein YP_002739349.1 29742 D 488221 CDS YP_002739350.1 225857840 7683248 30078..30377 1 NC_012468.1 gp18 30377 7683248 SP70585_0038 Streptococcus pneumoniae 70585 gp18 YP_002739350.1 30078 D 488221 CDS YP_002739351.1 225857841 7683735 30368..31156 1 NC_012468.1 identified by match to protein family HMM PF04271; match to protein family HMM TIGR01446; match to protein family HMM TIGR01714; putative phage-associated protein 31156 7683735 SP70585_0039 Streptococcus pneumoniae 70585 putative phage-associated protein YP_002739351.1 30368 D 488221 CDS YP_002739352.1 225857842 7682980 31144..31302 1 NC_012468.1 hypothetical protein 31302 7682980 SP70585_0040 Streptococcus pneumoniae 70585 hypothetical protein YP_002739352.1 31144 D 488221 CDS YP_002739353.1 225857843 7683791 31296..32066 1 NC_012468.1 gp21 32066 7683791 SP70585_0041 Streptococcus pneumoniae 70585 gp21 YP_002739353.1 31296 D 488221 CDS YP_002739354.1 225857844 7685077 32081..32275 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 32275 7685077 SP70585_0042 Streptococcus pneumoniae 70585 hypothetical protein YP_002739354.1 32081 D 488221 CDS YP_002739355.1 225857845 7683432 32275..32502 1 NC_012468.1 hypothetical protein 32502 7683432 SP70585_0043 Streptococcus pneumoniae 70585 hypothetical protein YP_002739355.1 32275 D 488221 CDS YP_002739356.1 225857846 7683764 32629..32793 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 32793 7683764 SP70585_0044 Streptococcus pneumoniae 70585 hypothetical protein YP_002739356.1 32629 D 488221 CDS YP_002739357.1 225857847 7684790 32964..33281 1 NC_012468.1 gp24 33281 7684790 SP70585_0045 Streptococcus pneumoniae 70585 gp24 YP_002739357.1 32964 D 488221 CDS YP_002739358.1 225857848 7683686 33283..33792 1 NC_012468.1 identified by match to protein family HMM PF07852; hypothetical protein 33792 7683686 SP70585_0046 Streptococcus pneumoniae 70585 hypothetical protein YP_002739358.1 33283 D 488221 CDS YP_002739359.1 225857849 7683388 33785..34375 1 NC_012468.1 identified by similarity to GB:AAZ82434.1; match to protein family HMM PF07852; hypothetical protein 34375 7683388 SP70585_0047 Streptococcus pneumoniae 70585 hypothetical protein YP_002739359.1 33785 D 488221 CDS YP_002739360.1 225857850 7685159 34375..34536 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 34536 7685159 SP70585_0048 Streptococcus pneumoniae 70585 hypothetical protein YP_002739360.1 34375 D 488221 CDS YP_002739361.1 225857851 7684961 34533..34667 1 NC_012468.1 gp27 34667 7684961 SP70585_0049 Streptococcus pneumoniae 70585 gp27 YP_002739361.1 34533 D 488221 CDS YP_002739362.1 225857852 7683562 34725..35069 1 NC_012468.1 identified by match to protein family HMM TIGR01671; hypothetical protein 35069 7683562 SP70585_0050 Streptococcus pneumoniae 70585 hypothetical protein YP_002739362.1 34725 D 488221 CDS YP_002739363.1 225857853 7685162 35069..35305 1 NC_012468.1 gp29 35305 7685162 SP70585_0051 Streptococcus pneumoniae 70585 gp29 YP_002739363.1 35069 D 488221 CDS YP_002739364.1 225857854 7685089 35467..35697 1 NC_012468.1 identified by match to protein family HMM PF01381; prophage LambdaBa04, DNA-binding protein 35697 7685089 SP70585_0052 Streptococcus pneumoniae 70585 prophage LambdaBa04, DNA-binding protein YP_002739364.1 35467 D 488221 CDS YP_002739365.1 225857855 7684212 35770..36198 1 NC_012468.1 identified by match to protein family HMM TIGR01637; gp31 36198 7684212 SP70585_0053 Streptococcus pneumoniae 70585 gp31 YP_002739365.1 35770 D 488221 CDS YP_002739366.1 225857856 7684382 36488..37054 1 NC_012468.1 identified by match to protein family HMM PF00589; site-specific recombinase, phage integrase family protein 37054 7684382 SP70585_0054 Streptococcus pneumoniae 70585 site-specific recombinase, phage integrase family protein YP_002739366.1 36488 D 488221 CDS YP_002739367.1 225857857 7685084 complement(37069..37200) 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 37200 7685084 SP70585_0055 Streptococcus pneumoniae 70585 hypothetical protein YP_002739367.1 37069 R 488221 CDS YP_002739368.1 225857858 7684806 37288..37632 1 NC_012468.1 identified by match to protein family HMM PF01844; HNH endonuclease domain protein 37632 7684806 SP70585_0056 Streptococcus pneumoniae 70585 HNH endonuclease domain protein YP_002739368.1 37288 D 488221 CDS YP_002739369.1 225857859 7683443 37771..39075 1 NC_012468.1 identified by match to protein family HMM PF07360; hypothetical protein 39075 7683443 SP70585_0057 Streptococcus pneumoniae 70585 hypothetical protein YP_002739369.1 37771 D 488221 CDS YP_002739370.1 225857860 7683206 39029..40420 1 NC_012468.1 gp35 40420 7683206 SP70585_0058 Streptococcus pneumoniae 70585 gp35 YP_002739370.1 39029 D 488221 CDS YP_002739371.1 225857861 7684118 40410..40649 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 40649 7684118 SP70585_0059 Streptococcus pneumoniae 70585 hypothetical protein YP_002739371.1 40410 D 488221 CDS YP_002739372.1 225857862 7685152 40702..40932 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 40932 7685152 SP70585_0060 Streptococcus pneumoniae 70585 hypothetical protein YP_002739372.1 40702 D 488221 CDS YP_002739373.1 225857863 7684337 40983..42395 1 NC_012468.1 identified by match to protein family HMM PF03354; putative phage terminase, large subunit 42395 7684337 SP70585_0061 Streptococcus pneumoniae 70585 putative phage terminase, large subunit YP_002739373.1 40983 D 488221 CDS YP_002739374.1 225857864 7684600 42477..42941 1 NC_012468.1 phage protein 42941 7684600 SP70585_0062 Streptococcus pneumoniae 70585 phage protein YP_002739374.1 42477 D 488221 CDS YP_002739375.1 225857865 7684107 42947..43846 1 NC_012468.1 major head protein 43846 7684107 SP70585_0063 Streptococcus pneumoniae 70585 major head protein YP_002739375.1 42947 D 488221 CDS YP_002739376.1 225857866 7683367 43852..44064 1 NC_012468.1 hypothetical protein 44064 7683367 SP70585_0064 Streptococcus pneumoniae 70585 hypothetical protein YP_002739376.1 43852 D 488221 CDS YP_002739377.1 225857867 7683706 44068..44508 1 NC_012468.1 hypothetical protein 44508 7683706 SP70585_0065 Streptococcus pneumoniae 70585 hypothetical protein YP_002739377.1 44068 D 488221 CDS YP_002739378.1 225857868 7682966 44486..44791 1 NC_012468.1 hypothetical protein 44791 7682966 SP70585_0066 Streptococcus pneumoniae 70585 hypothetical protein YP_002739378.1 44486 D 488221 CDS YP_002739379.1 225857869 7684550 44793..45020 1 NC_012468.1 hypothetical protein 45020 7684550 SP70585_0067 Streptococcus pneumoniae 70585 hypothetical protein YP_002739379.1 44793 D 488221 CDS YP_002739380.1 225857870 7684811 45017..45352 1 NC_012468.1 gp45 45352 7684811 SP70585_0068 Streptococcus pneumoniae 70585 gp45 YP_002739380.1 45017 D 488221 CDS YP_002739381.1 225857871 7684272 45368..45976 1 NC_012468.1 major tail protein 45976 7684272 SP70585_0069 Streptococcus pneumoniae 70585 major tail protein YP_002739381.1 45368 D 488221 CDS YP_002739382.1 225857872 7683439 45982..46257 1 NC_012468.1 phage protein 46257 7683439 SP70585_0070 Streptococcus pneumoniae 70585 phage protein YP_002739382.1 45982 D 488221 CDS YP_002739383.1 225857873 7683890 46269..46655 1 NC_012468.1 hypothetical protein 46655 7683890 SP70585_0071 Streptococcus pneumoniae 70585 hypothetical protein YP_002739383.1 46269 D 488221 CDS YP_002739384.1 225857874 7683049 46655..49120 1 NC_012468.1 identified by match to protein family HMM PF05017; PblA 49120 7683049 SP70585_0072 Streptococcus pneumoniae 70585 PblA YP_002739384.1 46655 D 488221 CDS YP_002739385.1 225857875 7683482 49120..49818 1 NC_012468.1 hypothetical protein 49818 7683482 SP70585_0073 Streptococcus pneumoniae 70585 hypothetical protein YP_002739385.1 49120 D 488221 CDS YP_002739386.1 225857876 7683831 49815..58727 1 NC_012468.1 identified by match to protein family HMM PF02018; match to protein family HMM TIGR01665; PblB 58727 7683831 SP70585_0074 Streptococcus pneumoniae 70585 PblB YP_002739386.1 49815 D 488221 CDS YP_002739387.1 225857877 7684254 58822..59025 1 NC_012468.1 hypothetical protein 59025 7684254 SP70585_0075 Streptococcus pneumoniae 70585 hypothetical protein YP_002739387.1 58822 D 488221 CDS YP_002739388.1 225857878 7682939 59028..59378 1 NC_012468.1 hypothetical protein 59378 7682939 SP70585_0076 Streptococcus pneumoniae 70585 hypothetical protein YP_002739388.1 59028 D 488221 CDS YP_002739389.1 225857879 7684136 59387..59803 1 NC_012468.1 identified by match to protein family HMM PF05105; match to protein family HMM TIGR01593; putative holin 1 59803 7684136 SP70585_0077 Streptococcus pneumoniae 70585 putative holin 1 YP_002739389.1 59387 D 488221 CDS YP_002739390.1 225857880 7684632 59807..60142 1 NC_012468.1 identified by match to protein family HMM TIGR01673; phage holin, LL-H family 60142 7684632 SP70585_0078 Streptococcus pneumoniae 70585 phage holin, LL-H family YP_002739390.1 59807 D 488221 CDS YP_002739391.1 225857881 7684018 60142..61098 1 NC_012468.1 identified by match to protein family HMM PF01473; match to protein family HMM PF01510; lytic amidase (N-acetylmuramoyl-L-alanine amidase) 61098 7684018 SP70585_0079 Streptococcus pneumoniae 70585 lytic amidase (N-acetylmuramoyl-L-alanine amidase) YP_002739391.1 60142 D 488221 CDS YP_002739392.1 225857882 7683276 complement(61236..61415) 1 NC_012468.1 hypothetical protein 61415 7683276 SP70585_0080 Streptococcus pneumoniae 70585 hypothetical protein YP_002739392.1 61236 R 488221 CDS YP_002739393.1 225857883 7683081 61967..62434 1 NC_012468.1 identified by match to protein family HMM PF00383; tRNA-specific adenosine deaminase 62434 7683081 SP70585_0081 Streptococcus pneumoniae 70585 tRNA-specific adenosine deaminase YP_002739393.1 61967 D 488221 CDS YP_002739394.1 225857884 7684280 62620..63063 1 NC_012468.1 catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 63063 dut 7684280 dut Streptococcus pneumoniae 70585 deoxyuridine 5'-triphosphate nucleotidohydrolase YP_002739394.1 62620 D 488221 CDS YP_002739395.1 225857885 7683737 63023..63580 1 NC_012468.1 identified by match to protein family HMM PF00300; phosphoglycerate mutase family protein 63580 7683737 SP70585_0083 Streptococcus pneumoniae 70585 phosphoglycerate mutase family protein YP_002739395.1 63023 D 488221 CDS YP_002739396.1 225857886 7683405 63693..64955 1 NC_012468.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 64955 radA 7683405 radA Streptococcus pneumoniae 70585 DNA repair protein RadA YP_002739396.1 63693 D 488221 CDS YP_002739397.1 225857887 7684513 65028..65525 1 NC_012468.1 identified by match to protein family HMM PF00484; carbonate dehydratase 65525 7684513 SP70585_0085 Streptococcus pneumoniae 70585 carbonate dehydratase YP_002739397.1 65028 D 488221 CDS YP_002739398.1 225857888 7684877 65550..66365 1 NC_012468.1 hypothetical protein 66365 7684877 SP70585_0086 Streptococcus pneumoniae 70585 hypothetical protein YP_002739398.1 65550 D 488221 CDS YP_002739399.1 225857889 7684736 66510..67478 1 NC_012468.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 67478 7684736 SP70585_0087 Streptococcus pneumoniae 70585 ribose-phosphate pyrophosphokinase YP_002739399.1 66510 D 488221 CDS YP_002739400.1 225857890 7683606 complement(67600..67893) 1 NC_012468.1 transposase 67893 7683606 SP70585_0088 Streptococcus pneumoniae 70585 transposase YP_002739400.1 67600 R 488221 CDS YP_002739401.1 225857891 7684088 complement(68020..68253) 1 NC_012468.1 hypothetical protein 68253 7684088 SP70585_0089 Streptococcus pneumoniae 70585 hypothetical protein YP_002739401.1 68020 R 488221 CDS YP_002739402.1 225857892 7683348 complement(68246..68362) 1 NC_012468.1 hypothetical protein 68362 7683348 SP70585_0090 Streptococcus pneumoniae 70585 hypothetical protein YP_002739402.1 68246 R 488221 CDS YP_002739403.1 225857893 7683542 complement(68577..68891) 1 NC_012468.1 hypothetical protein 68891 7683542 SP70585_0091 Streptococcus pneumoniae 70585 hypothetical protein YP_002739403.1 68577 R 488221 CDS YP_002739404.1 225857894 7683610 69183..71816 1 NC_012468.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 71816 7683610 SP70585_0092 Streptococcus pneumoniae 70585 DNA polymerase I YP_002739404.1 69183 D 488221 CDS YP_002739405.1 225857895 7684500 71901..72338 1 NC_012468.1 identified by match to protein family HMM PF02629; CoA binding protein 72338 7684500 SP70585_0093 Streptococcus pneumoniae 70585 CoA binding protein YP_002739405.1 71901 D 488221 CDS YP_002739406.1 225857896 7684893 complement(72576..73586) 1 NC_012468.1 identified by match to protein family HMM PF03601; membrane protein Spr0034 73586 7684893 SP70585_0094 Streptococcus pneumoniae 70585 membrane protein Spr0034 YP_002739406.1 72576 R 488221 CDS YP_002739407.1 225857897 7683962 73735..74904 1 NC_012468.1 catalyzes the transamination of the aromatic amino acid forming a ketoacid; first step in aromatic amino acid degradation in lactococci; aromatic amino acid aminotransferase 74904 7683962 SP70585_0095 Streptococcus pneumoniae 70585 aromatic amino acid aminotransferase YP_002739407.1 73735 D 488221 CDS YP_002739408.1 225857898 7682947 74901..75671 1 NC_012468.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO 75671 recO 7682947 recO Streptococcus pneumoniae 70585 DNA repair protein RecO YP_002739408.1 74901 D 488221 CDS YP_002739409.1 225857899 7683216 75668..76660 1 NC_012468.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; putative glycerol-3-phosphate acyltransferase PlsX 76660 plsX 7683216 plsX Streptococcus pneumoniae 70585 putative glycerol-3-phosphate acyltransferase PlsX YP_002739409.1 75668 D 488221 CDS YP_002739410.1 225857900 7683126 76666..76899 1 NC_012468.1 hypothetical protein 76899 7683126 SP70585_0098 Streptococcus pneumoniae 70585 hypothetical protein YP_002739410.1 76666 D 488221 CDS YP_002739411.1 225857901 7683866 76942..77235 1 NC_012468.1 mobile genetic element 77235 7683866 SP70585_0099 Streptococcus pneumoniae 70585 mobile genetic element YP_002739411.1 76942 D 488221 CDS YP_002739412.1 225857902 7683344 77438..77668 1 NC_012468.1 identified by match to protein family HMM TIGR01847; hypothetical protein 77668 7683344 SP70585_0100 Streptococcus pneumoniae 70585 hypothetical protein YP_002739412.1 77438 D 488221 CDS YP_002739413.1 225857903 7683201 77671..77796 1 NC_012468.1 hypothetical protein 77796 7683201 SP70585_0101 Streptococcus pneumoniae 70585 hypothetical protein YP_002739413.1 77671 D 488221 CDS YP_002739414.1 225857904 7683659 78094..78207 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 78207 7683659 SP70585_0102 Streptococcus pneumoniae 70585 hypothetical protein YP_002739414.1 78094 D 488221 CDS YP_002739415.1 225857905 7683001 78419..79312 1 NC_012468.1 identified by match to protein family HMM PF01381; XRE family transcriptional regulator 79312 7683001 SP70585_0103 Streptococcus pneumoniae 70585 XRE family transcriptional regulator YP_002739415.1 78419 D 488221 CDS YP_002739416.1 225857906 7684269 79855..80151 1 NC_012468.1 hypothetical protein 80151 7684269 SP70585_0104 Streptococcus pneumoniae 70585 hypothetical protein YP_002739416.1 79855 D 488221 CDS YP_002739417.1 225857907 7684375 80158..81294 1 NC_012468.1 hypothetical protein 81294 7684375 SP70585_0105 Streptococcus pneumoniae 70585 hypothetical protein YP_002739417.1 80158 D 488221 CDS YP_002739418.1 225857908 7684954 81531..81773 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 81773 7684954 SP70585_0106 Streptococcus pneumoniae 70585 hypothetical protein YP_002739418.1 81531 D 488221 CDS YP_002739419.1 225857909 7685099 81770..82366 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 82366 7685099 SP70585_0107 Streptococcus pneumoniae 70585 hypothetical protein YP_002739419.1 81770 D 488221 CDS YP_002739420.1 225857910 7683421 82347..82838 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 82838 7683421 SP70585_0108 Streptococcus pneumoniae 70585 hypothetical protein YP_002739420.1 82347 D 488221 CDS YP_002739421.1 225857911 7684886 83218..85371 1 NC_012468.1 identified by match to protein family HMM PF00005; match to protein family HMM PF00664; match to protein family HMM PF03412; match to protein family HMM TIGR01193; transport/processing ATP-binding protein ComA 85371 7684886 SP70585_0109 Streptococcus pneumoniae 70585 transport/processing ATP-binding protein ComA YP_002739421.1 83218 D 488221 CDS YP_002739422.1 225857912 7684988 85384..86733 1 NC_012468.1 identified by match to protein family HMM TIGR01000; transport protein ComB 86733 7684988 SP70585_0110 Streptococcus pneumoniae 70585 transport protein ComB YP_002739422.1 85384 D 488221 CDS YP_002739423.1 225857913 7683756 86904..87611 1 NC_012468.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase 87611 purC 7683756 purC Streptococcus pneumoniae 70585 phosphoribosylaminoimidazole-succinocarboxamide synthase YP_002739423.1 86904 D 488221 CDS YP_002739424.1 225857914 7683464 87813..91538 1 NC_012468.1 identified by match to protein family HMM PF02769; match to protein family HMM TIGR01857; phosphoribosylformylglycinamidine synthase 91538 7683464 SP70585_0112 Streptococcus pneumoniae 70585 phosphoribosylformylglycinamidine synthase YP_002739424.1 87813 D 488221 CDS YP_002739425.1 225857915 7683724 91631..93073 1 NC_012468.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 93073 purF 7683724 purF Streptococcus pneumoniae 70585 amidophosphoribosyltransferase YP_002739425.1 91631 D 488221 CDS YP_002739426.1 225857916 7683240 93110..94132 1 NC_012468.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 94132 purM 7683240 purM Streptococcus pneumoniae 70585 phosphoribosylaminoimidazole synthetase YP_002739426.1 93110 D 488221 CDS YP_002739427.1 225857917 7684195 94129..94674 1 NC_012468.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 94674 purN 7684195 purN Streptococcus pneumoniae 70585 phosphoribosylglycinamide formyltransferase YP_002739427.1 94129 D 488221 CDS YP_002739428.1 225857918 7683979 94758..95267 1 NC_012468.1 identified by match to protein family HMM PF04892; teicoplanin resistance protein 95267 7683979 SP70585_0116 Streptococcus pneumoniae 70585 teicoplanin resistance protein YP_002739428.1 94758 D 488221 CDS YP_002739429.1 225857919 7683040 95292..96839 1 NC_012468.1 involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 96839 purH 7683040 purH Streptococcus pneumoniae 70585 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase YP_002739429.1 95292 D 488221 CDS YP_002739430.1 225857920 7684001 96961..98223 1 NC_012468.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 98223 purD 7684001 purD Streptococcus pneumoniae 70585 phosphoribosylamine--glycine ligase YP_002739430.1 96961 D 488221 CDS YP_002739431.1 225857921 7684769 98480..98596 1 NC_012468.1 hypothetical protein 98596 7684769 SP70585_0119 Streptococcus pneumoniae 70585 hypothetical protein YP_002739431.1 98480 D 488221 CDS YP_002739432.1 225857922 7683330 98626..99114 1 NC_012468.1 identified by match to protein family HMM PF00731; match to protein family HMM TIGR01162; phosphoribosylaminoimidazole carboxylase, catalytic subunit 99114 purE 7683330 purE Streptococcus pneumoniae 70585 phosphoribosylaminoimidazole carboxylase, catalytic subunit YP_002739432.1 98626 D 488221 CDS YP_002739433.1 225857923 7683566 99101..100192 1 NC_012468.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 100192 purK 7683566 purK Streptococcus pneumoniae 70585 phosphoribosylaminoimidazole carboxylase ATPase subunit YP_002739433.1 99101 D 488221 CDS YP_002739434.1 225857924 7684617 100202..100429 1 NC_012468.1 hypothetical protein 100429 7684617 SP70585_0122 Streptococcus pneumoniae 70585 hypothetical protein YP_002739434.1 100202 D 488221 CDS YP_002739435.1 225857925 7683318 100492..101790 1 NC_012468.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 101790 purB 7683318 purB Streptococcus pneumoniae 70585 adenylosuccinate lyase YP_002739435.1 100492 D 488221 CDS YP_002739436.1 225857926 7684222 complement(101845..105807) 1 NC_012468.1 identified by match to protein family HMM PF00728; match to protein family HMM PF00746; match to protein family HMM PF04650; match to protein family HMM PF07501; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; beta-N-acetylhexosaminidase 105807 7684222 SP70585_0124 Streptococcus pneumoniae 70585 beta-N-acetylhexosaminidase YP_002739436.1 101845 R 488221 CDS YP_002739437.1 225857927 7683404 complement(106122..106865) 1 NC_012468.1 identified by match to protein family HMM PF00392; match to protein family HMM PF07702; GntR family transcriptional regulator 106865 7683404 SP70585_0125 Streptococcus pneumoniae 70585 GntR family transcriptional regulator YP_002739437.1 106122 R 488221 CDS YP_002739438.1 225857928 7683617 107186..108973 1 NC_012468.1 identified by match to protein family HMM PF01301; match to protein family HMM PF02449; beta-galactosidase 108973 7683617 SP70585_0126 Streptococcus pneumoniae 70585 beta-galactosidase YP_002739438.1 107186 D 488221 CDS YP_002739439.1 225857929 7684781 108970..109446 1 NC_012468.1 identified by match to protein family HMM PF03830; phosphotransferase system sugar-specific eiib component 109446 7684781 SP70585_0127 Streptococcus pneumoniae 70585 phosphotransferase system sugar-specific eiib component YP_002739439.1 108970 D 488221 CDS YP_002739440.1 225857930 7684016 109474..110379 1 NC_012468.1 identified by match to protein family HMM PF03609; PTS system, IIC component 110379 7684016 SP70585_0128 Streptococcus pneumoniae 70585 PTS system, IIC component YP_002739440.1 109474 D 488221 CDS YP_002739441.1 225857931 7684519 110366..111181 1 NC_012468.1 identified by match to protein family HMM PF03613; PTS system, IID component 111181 7684519 SP70585_0129 Streptococcus pneumoniae 70585 PTS system, IID component YP_002739441.1 110366 D 488221 CDS YP_002739442.1 225857932 7684372 111188..111592 1 NC_012468.1 identified by match to protein family HMM PF03610; phosphotransferase system sugar-specific EII component 111592 7684372 SP70585_0130 Streptococcus pneumoniae 70585 phosphotransferase system sugar-specific EII component YP_002739442.1 111188 D 488221 CDS YP_002739443.1 225857933 7683233 111845..113011 1 NC_012468.1 identified by match to protein family HMM PF01380; putative tagatose-6-phosphate ketose/aldose isomerase 113011 7683233 SP70585_0131 Streptococcus pneumoniae 70585 putative tagatose-6-phosphate ketose/aldose isomerase YP_002739443.1 111845 D 488221 CDS YP_002739444.1 225857934 7683722 113127..114164 1 NC_012468.1 identified by match to protein family HMM PF01263; aldose 1-epimerase 114164 7683722 SP70585_0132 Streptococcus pneumoniae 70585 aldose 1-epimerase YP_002739444.1 113127 D 488221 CDS YP_002739445.1 225857935 7684162 114371..115225 1 NC_012468.1 identified by match to protein family HMM PF00903; glyoxalase family protein 115225 7684162 SP70585_0133 Streptococcus pneumoniae 70585 glyoxalase family protein YP_002739445.1 114371 D 488221 CDS YP_002739446.1 225857936 7683061 115457..115594 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 115594 7683061 SP70585_0134 Streptococcus pneumoniae 70585 hypothetical protein YP_002739446.1 115457 D 488221 CDS YP_002739447.1 225857937 7683515 complement(115724..116110) 1 NC_012468.1 chlorohydrolase 116110 7683515 SP70585_0135 Streptococcus pneumoniae 70585 chlorohydrolase YP_002739447.1 115724 R 488221 CDS YP_002739448.1 225857938 7683788 complement(116331..116447) 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 116447 7683788 SP70585_0136 Streptococcus pneumoniae 70585 hypothetical protein YP_002739448.1 116331 R 488221 CDS YP_002739449.1 225857939 7683231 complement(116437..116556) 1 NC_012468.1 coenzyme A disulfide reductase 116556 7683231 SP70585_0137 Streptococcus pneumoniae 70585 coenzyme A disulfide reductase YP_002739449.1 116437 R 488221 CDS YP_002739450.1 225857940 7683663 116668..117432 1 NC_012468.1 identified by match to protein family HMM PF01048; phosphorylase, Pnp/Udp family 117432 7683663 SP70585_0138 Streptococcus pneumoniae 70585 phosphorylase, Pnp/Udp family YP_002739450.1 116668 D 488221 CDS YP_002739451.1 225857941 7685016 117688..117828 1 NC_012468.1 hypothetical protein 117828 7685016 SP70585_0139 Streptococcus pneumoniae 70585 hypothetical protein YP_002739451.1 117688 D 488221 CDS YP_002739452.1 225857942 7684922 117997..119376 1 NC_012468.1 identified by match to protein family HMM PF02386; Trk transporter membrane-spanning protein - K+ transport 119376 7684922 SP70585_0140 Streptococcus pneumoniae 70585 Trk transporter membrane-spanning protein - K+ transport YP_002739452.1 117997 D 488221 CDS YP_002739453.1 225857943 7684914 119390..120055 1 NC_012468.1 identified by match to protein family HMM PF02254; potassium uptake protein, Trk family 120055 7684914 SP70585_0141 Streptococcus pneumoniae 70585 potassium uptake protein, Trk family YP_002739453.1 119390 D 488221 CDS YP_002739454.1 225857944 7684376 120190..120348 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 120348 7684376 SP70585_0142 Streptococcus pneumoniae 70585 hypothetical protein YP_002739454.1 120190 D 488221 CDS YP_002739455.1 225857945 7684564 120410..120949 1 NC_012468.1 identified by match to protein family HMM PF00535; cell wall biogenesis glycosyltransferase 120949 7684564 SP70585_0143 Streptococcus pneumoniae 70585 cell wall biogenesis glycosyltransferase YP_002739455.1 120410 D 488221 CDS YP_002739456.1 225857946 7683845 121016..121426 1 NC_012468.1 cell wall biogenesis glycosyltransferase 121426 7683845 SP70585_0144 Streptococcus pneumoniae 70585 cell wall biogenesis glycosyltransferase YP_002739456.1 121016 D 488221 CDS YP_002739457.1 225857947 7684757 121542..125027 1 NC_012468.1 identified by match to protein family HMM PF00746; match to protein family HMM PF04650; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; cell wall surface anchor family protein 125027 7684757 SP70585_0145 Streptococcus pneumoniae 70585 cell wall surface anchor family protein YP_002739457.1 121542 D 488221 CDS YP_002739458.1 225857948 7683326 125194..125892 1 NC_012468.1 identified by match to protein family HMM PF00072; match to protein family HMM PF00486; response regulator SaeR 125892 7683326 SP70585_0146 Streptococcus pneumoniae 70585 response regulator SaeR YP_002739458.1 125194 D 488221 CDS YP_002739459.1 225857949 7683943 125889..126941 1 NC_012468.1 identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; histidine kinase 126941 7683943 SP70585_0147 Streptococcus pneumoniae 70585 histidine kinase YP_002739459.1 125889 D 488221 CDS YP_002739460.1 225857950 7684864 127136..127747 1 NC_012468.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 127747 rpsD 7684864 rpsD Streptococcus pneumoniae 70585 30S ribosomal protein S4 YP_002739460.1 127136 D 488221 CDS YP_002739461.1 225857951 7684503 127932..128090 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase 128090 7684503 SP70585_0149 Streptococcus pneumoniae 70585 transposase YP_002739461.1 127932 D 488221 CDS YP_002739462.1 225857952 7683533 128495..128716 1 NC_012468.1 hypothetical protein 128716 7683533 SP70585_0150 Streptococcus pneumoniae 70585 hypothetical protein YP_002739462.1 128495 D 488221 CDS YP_002739463.1 225857953 7683806 129035..129964 1 NC_012468.1 identified by match to protein family HMM PF00528; ABC transporter permease 129964 7683806 SP70585_0151 Streptococcus pneumoniae 70585 ABC transporter permease YP_002739463.1 129035 D 488221 CDS YP_002739464.1 225857954 7684050 129978..130901 1 NC_012468.1 identified by match to protein family HMM PF00528; protein LplC 130901 7684050 SP70585_0152 Streptococcus pneumoniae 70585 protein LplC YP_002739464.1 129978 D 488221 CDS YP_002739465.1 225857955 7683401 131111..132586 1 NC_012468.1 identified by match to protein family HMM PF01547; ABC transporter substrate-binding protein 132586 7683401 SP70585_0153 Streptococcus pneumoniae 70585 ABC transporter substrate-binding protein YP_002739465.1 131111 D 488221 CDS YP_002739466.1 225857956 7683455 132858..133844 1 NC_012468.1 identified by match to protein family HMM PF00581; hypothetical protein 133844 7683455 SP70585_0154 Streptococcus pneumoniae 70585 hypothetical protein YP_002739466.1 132858 D 488221 CDS YP_002739467.1 225857957 7684972 133966..134826 1 NC_012468.1 hypothetical protein 134826 7684972 SP70585_0155 Streptococcus pneumoniae 70585 hypothetical protein YP_002739467.1 133966 D 488221 CDS YP_002739468.1 225857958 7682906 complement(135004..136068) 1 NC_012468.1 hypothetical protein 136068 7682906 SP70585_0156 Streptococcus pneumoniae 70585 hypothetical protein YP_002739468.1 135004 R 488221 CDS YP_002739469.1 225857959 7684020 complement(136131..137042) 1 NC_012468.1 hypothetical protein 137042 7684020 SP70585_0157 Streptococcus pneumoniae 70585 hypothetical protein YP_002739469.1 136131 R 488221 CDS YP_002739470.1 225857960 7684582 complement(137035..137628) 1 NC_012468.1 hypothetical protein 137628 7684582 SP70585_0158 Streptococcus pneumoniae 70585 hypothetical protein YP_002739470.1 137035 R 488221 CDS YP_002739471.1 225857961 7685051 complement(137615..137941) 1 NC_012468.1 identified by match to protein family HMM PF03551; transcription regulator 137941 7685051 SP70585_0159 Streptococcus pneumoniae 70585 transcription regulator YP_002739471.1 137615 R 488221 CDS YP_002739472.1 225857962 7684484 complement(138080..139246) 1 NC_012468.1 identified by match to protein family HMM PF07690; cyanate permease 139246 7684484 SP70585_0160 Streptococcus pneumoniae 70585 cyanate permease YP_002739472.1 138080 R 488221 CDS YP_002739473.1 225857963 7684974 139304..139531 1 NC_012468.1 hypothetical protein 139531 7684974 SP70585_0161 Streptococcus pneumoniae 70585 hypothetical protein YP_002739473.1 139304 D 488221 CDS YP_002739474.1 225857964 7684590 139601..139828 1 NC_012468.1 hypothetical protein 139828 7684590 SP70585_0162 Streptococcus pneumoniae 70585 hypothetical protein YP_002739474.1 139601 D 488221 CDS YP_002739475.1 225857965 7683025 139898..140125 1 NC_012468.1 hypothetical protein 140125 7683025 SP70585_0163 Streptococcus pneumoniae 70585 hypothetical protein YP_002739475.1 139898 D 488221 CDS YP_002739476.1 225857966 7683159 140292..141122 1 NC_012468.1 identified by match to protein family HMM PF00535; amylovoran biosynthesis glycosyltransferase AmsE 141122 7683159 SP70585_0164 Streptococcus pneumoniae 70585 amylovoran biosynthesis glycosyltransferase AmsE YP_002739476.1 140292 D 488221 CDS YP_002739477.1 225857967 7683792 141208..143058 1 NC_012468.1 identified by match to protein family HMM PF00106; match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF04321; match to protein family HMM PF07993; CapD protein, required for the biosynthesis of type 1 capsular polysaccharide 143058 7683792 SP70585_0166 Streptococcus pneumoniae 70585 CapD protein, required for the biosynthesis of type 1 capsular polysaccharide YP_002739477.1 141208 D 488221 CDS YP_002739478.1 225857968 7684421 complement(143037..143312) 1 NC_012468.1 chlorohydrolase 143312 7684421 SP70585_0165 Streptococcus pneumoniae 70585 chlorohydrolase YP_002739478.1 143037 R 488221 CDS YP_002739479.1 225857969 7682983 complement(143362..143994) 1 NC_012468.1 identified by match to protein family HMM PF00702; phosphoglycolate phosphatase 143994 7682983 SP70585_0167 Streptococcus pneumoniae 70585 phosphoglycolate phosphatase YP_002739479.1 143362 R 488221 CDS YP_002739480.1 225857970 7683394 complement(144016..144888) 1 NC_012468.1 identified by match to protein family HMM PF03313; match to protein family HMM TIGR00718; L-serine dehydratase, iron-sulfur-dependent, alpha subunit 144888 sdaAA 7683394 sdaAA Streptococcus pneumoniae 70585 L-serine dehydratase, iron-sulfur-dependent, alpha subunit YP_002739480.1 144016 R 488221 CDS YP_002739481.1 225857971 7685151 complement(144897..145568) 1 NC_012468.1 identified by match to protein family HMM PF01842; match to protein family HMM PF03315; match to protein family HMM TIGR00719; L-serine dehydratase, iron-sulfur-dependent, beta subunit 145568 sdaAB 7685151 sdaAB Streptococcus pneumoniae 70585 L-serine dehydratase, iron-sulfur-dependent, beta subunit YP_002739481.1 144897 R 488221 CDS YP_002739482.1 225857972 7684993 145810..146397 1 NC_012468.1 identified by match to protein family HMM PF01476; LysM domain protein 146397 7684993 SP70585_0170 Streptococcus pneumoniae 70585 LysM domain protein YP_002739482.1 145810 D 488221 CDS YP_002739483.1 225857973 7683011 complement(146449..146769) 1 NC_012468.1 hypothetical protein 146769 7683011 SP70585_0171 Streptococcus pneumoniae 70585 hypothetical protein YP_002739483.1 146449 R 488221 CDS YP_002739484.1 225857974 7683670 147195..147482 1 NC_012468.1 identified by match to protein family HMM TIGR01653; bacteriocin, putative 147482 7683670 SP70585_0172 Streptococcus pneumoniae 70585 bacteriocin, putative YP_002739484.1 147195 D 488221 CDS YP_002739485.1 225857975 7683679 147534..149642 1 NC_012468.1 identified by match to protein family HMM TIGR01654; amino acid ABC transporter permease 149642 7683679 SP70585_0173 Streptococcus pneumoniae 70585 amino acid ABC transporter permease YP_002739485.1 147534 D 488221 CDS YP_002739486.1 225857976 7683370 149639..150280 1 NC_012468.1 identified by match to protein family HMM PF00005; macrolide export ATP-binding/permease MacB 150280 7683370 SP70585_0174 Streptococcus pneumoniae 70585 macrolide export ATP-binding/permease MacB YP_002739486.1 149639 D 488221 CDS YP_002739487.1 225857977 7684603 150487..151293 1 NC_012468.1 identified by match to protein family HMM PF00497; amino acid ABC transporter substrate-binding protein 151293 7684603 SP70585_0175 Streptococcus pneumoniae 70585 amino acid ABC transporter substrate-binding protein YP_002739487.1 150487 D 488221 CDS YP_002739488.1 225857978 7684924 152536..153927 1 NC_012468.1 catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 153927 argH 7684924 argH Streptococcus pneumoniae 70585 argininosuccinate lyase YP_002739488.1 152536 D 488221 CDS YP_002739489.1 225857979 7684771 complement(154216..155079) 1 NC_012468.1 identified by match to protein family HMM PF01381; helix-turn-helix domain protein 155079 7684771 SP70585_0179 Streptococcus pneumoniae 70585 helix-turn-helix domain protein YP_002739489.1 154216 R 488221 CDS YP_002739490.1 225857980 7683531 155533..157764 1 NC_012468.1 identified by match to protein family HMM PF00005; match to protein family HMM PF00664; match to protein family HMM PF03412; match to protein family HMM TIGR01193; transport/processing ATP-binding protein ComA 157764 7683531 SP70585_0180 Streptococcus pneumoniae 70585 transport/processing ATP-binding protein ComA YP_002739490.1 155533 D 488221 CDS YP_002739491.1 225857981 7683186 157757..158224 1 NC_012468.1 hypothetical protein 158224 7683186 SP70585_0181 Streptococcus pneumoniae 70585 hypothetical protein YP_002739491.1 157757 D 488221 CDS YP_002739492.1 225857982 7685093 158221..159573 1 NC_012468.1 hypothetical protein 159573 7685093 SP70585_0182 Streptococcus pneumoniae 70585 hypothetical protein YP_002739492.1 158221 D 488221 CDS YP_002739493.1 225857983 7685171 159719..160099 1 NC_012468.1 hypothetical protein 160099 7685171 SP70585_0183 Streptococcus pneumoniae 70585 hypothetical protein YP_002739493.1 159719 D 488221 CDS YP_002739494.1 225857984 7684965 complement(160602..160922) 1 NC_012468.1 hypothetical protein 160922 7684965 SP70585_0184 Streptococcus pneumoniae 70585 hypothetical protein YP_002739494.1 160602 R 488221 CDS YP_002739495.1 225857985 7684596 161680..162051 1 NC_012468.1 hypothetical protein 162051 7684596 SP70585_0185 Streptococcus pneumoniae 70585 hypothetical protein YP_002739495.1 161680 D 488221 CDS YP_002739496.1 225857986 7683430 162059..162271 1 NC_012468.1 hypothetical protein 162271 7683430 SP70585_0186 Streptococcus pneumoniae 70585 hypothetical protein YP_002739496.1 162059 D 488221 CDS YP_002739497.1 225857987 7685041 162645..162770 1 NC_012468.1 hypothetical protein 162770 7685041 SP70585_0187 Streptococcus pneumoniae 70585 hypothetical protein YP_002739497.1 162645 D 488221 CDS YP_002739498.1 225857988 7684728 162751..162996 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 162996 7684728 SP70585_0188 Streptococcus pneumoniae 70585 hypothetical protein YP_002739498.1 162751 D 488221 CDS YP_002739499.1 225857989 7683342 163153..164211 1 NC_012468.1 hypothetical protein 164211 7683342 SP70585_0189 Streptococcus pneumoniae 70585 hypothetical protein YP_002739499.1 163153 D 488221 CDS YP_002739500.1 225857990 7684967 164526..165503 1 NC_012468.1 hypothetical protein 165503 7684967 SP70585_0190 Streptococcus pneumoniae 70585 hypothetical protein YP_002739500.1 164526 D 488221 CDS YP_002739501.1 225857991 7683000 165880..166254 1 NC_012468.1 hypothetical protein 166254 7683000 SP70585_0191 Streptococcus pneumoniae 70585 hypothetical protein YP_002739501.1 165880 D 488221 CDS YP_002739502.1 225857992 7683548 166261..166443 1 NC_012468.1 hypothetical protein 166443 7683548 SP70585_0192 Streptococcus pneumoniae 70585 hypothetical protein YP_002739502.1 166261 D 488221 CDS YP_002739503.1 225857993 7683635 166462..167364 1 NC_012468.1 hypothetical protein 167364 7683635 SP70585_0193 Streptococcus pneumoniae 70585 hypothetical protein YP_002739503.1 166462 D 488221 CDS YP_002739504.1 225857994 7684856 167420..167773 1 NC_012468.1 hypothetical protein 167773 7684856 SP70585_0194 Streptococcus pneumoniae 70585 hypothetical protein YP_002739504.1 167420 D 488221 CDS YP_002739505.1 225857995 7683882 167770..168498 1 NC_012468.1 hypothetical protein 168498 7683882 SP70585_0195 Streptococcus pneumoniae 70585 hypothetical protein YP_002739505.1 167770 D 488221 CDS YP_002739506.1 225857996 7683934 169625..170128 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 170128 7683934 SP70585_0196 Streptococcus pneumoniae 70585 hypothetical protein YP_002739506.1 169625 D 488221 CDS YP_002739507.1 225857997 7684154 170414..172330 1 NC_012468.1 identified by match to protein family HMM PF01473; surface protein PspA 172330 7684154 SP70585_0197 Streptococcus pneumoniae 70585 surface protein PspA YP_002739507.1 170414 D 488221 CDS YP_002739508.1 225857998 7684279 172731..173852 1 NC_012468.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 173852 mnmA 7684279 mnmA Streptococcus pneumoniae 70585 tRNA-specific 2-thiouridylase MnmA YP_002739508.1 172731 D 488221 CDS YP_002739509.1 225857999 7685050 173993..174391 1 NC_012468.1 identified by match to protein family HMM PF00293; MutT/nudix family protein 174391 7685050 SP70585_0199 Streptococcus pneumoniae 70585 MutT/nudix family protein YP_002739509.1 173993 D 488221 CDS YP_002739510.1 225858000 7684004 174458..176371 1 NC_012468.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA 176371 gidA 7684004 gidA Streptococcus pneumoniae 70585 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA YP_002739510.1 174458 D 488221 CDS YP_002739511.1 225858001 7682986 complement(176750..178429) 1 NC_012468.1 identified by match to protein family HMM PF00753; match to protein family HMM PF07521; match to protein family HMM TIGR00649; metallo-beta-lactamase superfamily protein 178429 7682986 SP70585_0201 Streptococcus pneumoniae 70585 metallo-beta-lactamase superfamily protein YP_002739511.1 176750 R 488221 CDS YP_002739512.1 225858002 7683026 complement(178431..178664) 1 NC_012468.1 identified by match to protein family HMM PF07288; hypothetical protein 178664 7683026 SP70585_0202 Streptococcus pneumoniae 70585 hypothetical protein YP_002739512.1 178431 R 488221 CDS YP_002739513.1 225858003 7684701 complement(179482..179634) 1 NC_012468.1 identified by match to protein family HMM TIGR01847; bacteriocin-type signal sequence domain protein 179634 7684701 SP70585_0203 Streptococcus pneumoniae 70585 bacteriocin-type signal sequence domain protein YP_002739513.1 179482 R 488221 CDS YP_002739514.1 225858004 7684134 complement(179636..179821) 1 NC_012468.1 hypothetical protein 179821 7684134 SP70585_0204 Streptococcus pneumoniae 70585 hypothetical protein YP_002739514.1 179636 R 488221 CDS YP_002739515.1 225858005 7683146 179999..180682 1 NC_012468.1 identified by match to protein family HMM PF00814; glycoprotein endopeptidase 180682 7683146 SP70585_0205 Streptococcus pneumoniae 70585 glycoprotein endopeptidase YP_002739515.1 179999 D 488221 CDS YP_002739516.1 225858006 7684364 180679..181116 1 NC_012468.1 identified by match to protein family HMM PF00583; match to protein family HMM TIGR01575; ribosomal-protein-alanine acetyltransferase 181116 rimI 7684364 rimI Streptococcus pneumoniae 70585 ribosomal-protein-alanine acetyltransferase YP_002739516.1 180679 D 488221 CDS YP_002739517.1 225858007 7684266 181106..182116 1 NC_012468.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; putative DNA-binding/iron metalloprotein/AP endonuclease 182116 7684266 SP70585_0207 Streptococcus pneumoniae 70585 putative DNA-binding/iron metalloprotein/AP endonuclease YP_002739517.1 181106 D 488221 CDS YP_002739518.1 225858008 7684494 complement(182156..182542) 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase 182542 7684494 SP70585_0208 Streptococcus pneumoniae 70585 transposase YP_002739518.1 182156 R 488221 CDS YP_002739519.1 225858009 7683139 complement(182533..183510) 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01610; transposase 183510 7683139 SP70585_0209 Streptococcus pneumoniae 70585 transposase YP_002739519.1 182533 R 488221 CDS YP_002739520.1 225858010 7685180 184731..185450 1 NC_012468.1 glycosyl transferase, group 1 family protein 185450 7685180 SP70585_0210 Streptococcus pneumoniae 70585 glycosyl transferase, group 1 family protein YP_002739520.1 184731 D 488221 CDS YP_002739521.1 225858011 7684990 185537..187153 1 NC_012468.1 identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 187153 7684990 SP70585_0211 Streptococcus pneumoniae 70585 ABC transporter ATP-binding protein YP_002739521.1 185537 D 488221 CDS YP_002739522.1 225858012 7684541 187617..187841 1 NC_012468.1 hypothetical protein 187841 7684541 SP70585_0212 Streptococcus pneumoniae 70585 hypothetical protein YP_002739522.1 187617 D 488221 CDS YP_002739523.1 225858013 7683382 187853..188602 1 NC_012468.1 identified by match to protein family HMM PF02585; GlcNAc-PI de-N-acetylase family 188602 7683382 SP70585_0213 Streptococcus pneumoniae 70585 GlcNAc-PI de-N-acetylase family YP_002739523.1 187853 D 488221 CDS YP_002739524.1 225858014 7683692 190183..191046 1 NC_012468.1 identified by match to protein family HMM TIGR01716; MutR 191046 7683692 SP70585_0215 Streptococcus pneumoniae 70585 MutR YP_002739524.1 190183 D 488221 CDS YP_002739525.1 225858015 7683189 191337..191534 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 191534 7683189 SP70585_0216 Streptococcus pneumoniae 70585 hypothetical protein YP_002739525.1 191337 D 488221 CDS YP_002739526.1 225858016 7685181 191602..192267 1 NC_012468.1 identified by match to protein family HMM PF02517; caax amino protease family 192267 7685181 SP70585_0217 Streptococcus pneumoniae 70585 caax amino protease family YP_002739526.1 191602 D 488221 CDS YP_002739527.1 225858017 7685000 192339..193565 1 NC_012468.1 transporter major facilitator family protein 193565 7685000 SP70585_0218 Streptococcus pneumoniae 70585 transporter major facilitator family protein YP_002739527.1 192339 D 488221 CDS YP_002739528.1 225858018 7683818 complement(193799..194038) 1 NC_012468.1 chlorohydrolase 194038 7683818 SP70585_0219 Streptococcus pneumoniae 70585 chlorohydrolase YP_002739528.1 193799 R 488221 CDS YP_002739529.1 225858019 7684716 194754..195077 1 NC_012468.1 identified by match to protein family HMM PF05437; branched-chain amino acid transport protein AzlD 195077 7684716 SP70585_0221 Streptococcus pneumoniae 70585 branched-chain amino acid transport protein AzlD YP_002739529.1 194754 D 488221 CDS YP_002739530.1 225858020 7685168 195181..196011 1 NC_012468.1 identified by match to protein family HMM PF00497; amino acid ABC transporter substrate-binding protein 196011 7685168 SP70585_0222 Streptococcus pneumoniae 70585 amino acid ABC transporter substrate-binding protein YP_002739530.1 195181 D 488221 CDS YP_002739531.1 225858021 7684163 196165..197019 1 NC_012468.1 identified by match to protein family HMM PF03180; lipoprotein 197019 7684163 SP70585_0223 Streptococcus pneumoniae 70585 lipoprotein YP_002739531.1 196165 D 488221 CDS YP_002739532.1 225858022 7684592 197119..198492 1 NC_012468.1 identified by match to protein family HMM PF01546; match to protein family HMM PF07687; acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase 198492 7684592 SP70585_0224 Streptococcus pneumoniae 70585 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase YP_002739532.1 197119 D 488221 CDS YP_002739533.1 225858023 7684325 198485..199546 1 NC_012468.1 identified by match to protein family HMM PF00005; methionine import ATP-binding protein MetN 199546 7684325 SP70585_0225 Streptococcus pneumoniae 70585 methionine import ATP-binding protein MetN YP_002739533.1 198485 D 488221 CDS YP_002739534.1 225858024 7684517 199548..200240 1 NC_012468.1 identified by match to protein family HMM PF00528; ABC transporter permease 200240 7684517 SP70585_0226 Streptococcus pneumoniae 70585 ABC transporter permease YP_002739534.1 199548 D 488221 CDS YP_002739535.1 225858025 7684444 complement(200269..200838) 1 NC_012468.1 identified by match to protein family HMM TIGR02185; membrane-bound protein 200838 7684444 SP70585_0227 Streptococcus pneumoniae 70585 membrane-bound protein YP_002739535.1 200269 R 488221 CDS YP_002739536.1 225858026 7684521 200973..201587 1 NC_012468.1 identified by match to protein family HMM PF04854; hypothetical protein 201587 7684521 SP70585_0228 Streptococcus pneumoniae 70585 hypothetical protein YP_002739536.1 200973 D 488221 CDS YP_002739537.1 225858027 7682974 201637..203235 1 NC_012468.1 identified by match to protein family HMM PF00672; match to protein family HMM PF02518; match to protein family HMM PF06580; sensor histidine kinase, putative 203235 7682974 SP70585_0229 Streptococcus pneumoniae 70585 sensor histidine kinase, putative YP_002739537.1 201637 D 488221 CDS YP_002739538.1 225858028 7683874 203247..204533 1 NC_012468.1 identified by match to protein family HMM PF00072; match to protein family HMM PF00165; DNA-binding response regulator 204533 7683874 SP70585_0230 Streptococcus pneumoniae 70585 DNA-binding response regulator YP_002739538.1 203247 D 488221 CDS YP_002739539.1 225858029 7685079 204585..205118 1 NC_012468.1 hypothetical protein 205118 7685079 SP70585_0231 Streptococcus pneumoniae 70585 hypothetical protein YP_002739539.1 204585 D 488221 CDS YP_002739540.1 225858030 7683543 205196..205666 1 NC_012468.1 has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; flavoprotein NrdI 205666 7683543 SP70585_0232 Streptococcus pneumoniae 70585 flavoprotein NrdI YP_002739540.1 205196 D 488221 CDS YP_002739541.1 225858031 7684175 complement(205959..207221) 1 NC_012468.1 mn2+ and fe2+ transporter of the nramp family 207221 7684175 SP70585_0233 Streptococcus pneumoniae 70585 mn2+ and fe2+ transporter of the nramp family YP_002739541.1 205959 R 488221 CDS YP_002739542.1 225858032 7684883 complement(207531..207989) 1 NC_012468.1 hypothetical protein 207989 7684883 SP70585_0234 Streptococcus pneumoniae 70585 hypothetical protein YP_002739542.1 207531 R 488221 CDS YP_002739543.1 225858033 7683093 complement(207986..208426) 1 NC_012468.1 identified by match to protein family HMM PF04397; response regulator of the LytR/AlgR family 208426 7683093 SP70585_0235 Streptococcus pneumoniae 70585 response regulator of the LytR/AlgR family YP_002739543.1 207986 R 488221 CDS YP_002739544.1 225858034 7684130 208542..208721 1 NC_012468.1 hypothetical protein 208721 7684130 SP70585_0236 Streptococcus pneumoniae 70585 hypothetical protein YP_002739544.1 208542 D 488221 CDS YP_002739545.1 225858035 7683991 208693..208893 1 NC_012468.1 MutL 208893 7683991 SP70585_0237 Streptococcus pneumoniae 70585 MutL YP_002739545.1 208693 D 488221 CDS YP_002739546.1 225858036 7683222 complement(209218..209685) 1 NC_012468.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase 209685 ribH 7683222 ribH Streptococcus pneumoniae 70585 6,7-dimethyl-8-ribityllumazine synthase YP_002739546.1 209218 R 488221 CDS YP_002739547.1 225858037 7684262 complement(209686..210891) 1 NC_012468.1 identified by match to protein family HMM PF00925; match to protein family HMM PF00926; match to protein family HMM TIGR00505; match to protein family HMM TIGR00506; riboflavin biosynthesis protein ribAB 210891 7684262 SP70585_0239 Streptococcus pneumoniae 70585 riboflavin biosynthesis protein ribAB YP_002739547.1 209686 R 488221 CDS YP_002739548.1 225858038 7684443 complement(210911..211546) 1 NC_012468.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha 211546 ribE 7684443 ribE Streptococcus pneumoniae 70585 riboflavin synthase subunit alpha YP_002739548.1 210911 R 488221 CDS YP_002739549.1 225858039 7683773 complement(211531..212631) 1 NC_012468.1 identified by match to protein family HMM PF00383; match to protein family HMM PF01872; match to protein family HMM TIGR00227; match to protein family HMM TIGR00326; riboflavin biosynthesis protein RibD 212631 ribD 7683773 ribD Streptococcus pneumoniae 70585 riboflavin biosynthesis protein RibD YP_002739549.1 211531 R 488221 CDS YP_002739550.1 225858040 7684861 213035..213628 1 NC_012468.1 plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 213628 ruvA 7684861 ruvA Streptococcus pneumoniae 70585 Holliday junction DNA helicase RuvA YP_002739550.1 213035 D 488221 CDS YP_002739551.1 225858041 7684760 213638..214201 1 NC_012468.1 identified by match to protein family HMM PF03352; DNA-3-methyladenine glycosylase 1 214201 7684760 SP70585_0243 Streptococcus pneumoniae 70585 DNA-3-methyladenine glycosylase 1 YP_002739551.1 213638 D 488221 CDS YP_002739552.1 225858042 7684863 214198..214875 1 NC_012468.1 identified by match to protein family HMM PF02517; caax amino protease family 214875 7684863 SP70585_0244 Streptococcus pneumoniae 70585 caax amino protease family YP_002739552.1 214198 D 488221 CDS YP_002739553.1 225858043 7683873 complement(215030..216061) 1 NC_012468.1 identified by match to protein family HMM PF02016; MccC family protein 216061 7683873 SP70585_0245 Streptococcus pneumoniae 70585 MccC family protein YP_002739553.1 215030 R 488221 CDS YP_002739554.1 225858044 7683973 complement(216316..216999) 1 NC_012468.1 identified by match to protein family HMM PF06570; hypothetical protein 216999 7683973 SP70585_0246 Streptococcus pneumoniae 70585 hypothetical protein YP_002739554.1 216316 R 488221 CDS YP_002739555.1 225858045 7684621 complement(217011..217955) 1 NC_012468.1 identified by match to protein family HMM PF01544; magnesium and cobalt transporter 217955 7684621 SP70585_0247 Streptococcus pneumoniae 70585 magnesium and cobalt transporter YP_002739555.1 217011 R 488221 CDS YP_002739556.1 225858046 7684270 218087..220918 1 NC_012468.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 220918 uvrA 7684270 uvrA Streptococcus pneumoniae 70585 excinuclease ABC subunit A YP_002739556.1 218087 D 488221 CDS YP_002739557.1 225858047 7684321 220911..221972 1 NC_012468.1 identified by match to protein family HMM PF00557; match to protein family HMM PF01321; Xaa-Pro dipeptidase 221972 7684321 SP70585_0249 Streptococcus pneumoniae 70585 Xaa-Pro dipeptidase YP_002739557.1 220911 D 488221 CDS YP_002739558.1 225858048 7683747 222104..222502 1 NC_012468.1 the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress; transcriptional regulator Spx 222502 spxA 7683747 spxA Streptococcus pneumoniae 70585 transcriptional regulator Spx YP_002739558.1 222104 D 488221 CDS YP_002739559.1 225858049 7684121 222568..223137 1 NC_012468.1 lipoprotein, putative 223137 7684121 SP70585_0251 Streptococcus pneumoniae 70585 lipoprotein, putative YP_002739559.1 222568 D 488221 CDS YP_002739560.1 225858050 7683472 223224..223490 1 NC_012468.1 identified by match to protein family HMM PF06135; hypothetical protein 223490 7683472 SP70585_0252 Streptococcus pneumoniae 70585 hypothetical protein YP_002739560.1 223224 D 488221 CDS YP_002739561.1 225858051 7683650 223494..223913 1 NC_012468.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 223913 7683650 SP70585_0253 Streptococcus pneumoniae 70585 Holliday junction resolvase-like protein YP_002739561.1 223494 D 488221 CDS YP_002739562.1 225858052 7684057 223929..224234 1 NC_012468.1 identified by match to protein family HMM PF06949; hypothetical protein 224234 7684057 SP70585_0254 Streptococcus pneumoniae 70585 hypothetical protein YP_002739562.1 223929 D 488221 CDS YP_002739563.1 225858053 7684211 224442..225692 1 NC_012468.1 identified by match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01499; dihydrofolate:folylpolyglutamate synthetase 225692 7684211 SP70585_0255 Streptococcus pneumoniae 70585 dihydrofolate:folylpolyglutamate synthetase YP_002739563.1 224442 D 488221 CDS YP_002739564.1 225858054 7684653 225689..226234 1 NC_012468.1 hypothetical protein 226234 7684653 SP70585_0256 Streptococcus pneumoniae 70585 hypothetical protein YP_002739564.1 225689 D 488221 CDS YP_002739565.1 225858055 7684012 226380..227912 1 NC_012468.1 identified by match to protein family HMM PF00614; cardiolipin synthase 227912 7684012 SP70585_0257 Streptococcus pneumoniae 70585 cardiolipin synthase YP_002739565.1 226380 D 488221 CDS YP_002739566.1 225858056 7683252 228170..229708 1 NC_012468.1 competence-induced protein Ccs4 229708 7683252 SP70585_0258 Streptococcus pneumoniae 70585 competence-induced protein Ccs4 YP_002739566.1 228170 D 488221 CDS YP_002739567.1 225858057 7684758 229828..232035 1 NC_012468.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; anaerobic ribonucleoside triphosphate reductase 232035 nrdD 7684758 nrdD Streptococcus pneumoniae 70585 anaerobic ribonucleoside triphosphate reductase YP_002739567.1 229828 D 488221 CDS YP_002739568.1 225858058 7684725 232047..232187 1 NC_012468.1 hypothetical protein 232187 7684725 SP70585_0260 Streptococcus pneumoniae 70585 hypothetical protein YP_002739568.1 232047 D 488221 CDS YP_002739569.1 225858059 7683313 232231..232737 1 NC_012468.1 identified by match to protein family HMM PF00583; acetyltransferase, gnat family 232737 7683313 SP70585_0261 Streptococcus pneumoniae 70585 acetyltransferase, gnat family YP_002739569.1 232231 D 488221 CDS YP_002739570.1 225858060 7685170 232730..233320 1 NC_012468.1 identified by match to protein family HMM PF04055; match to protein family HMM TIGR02491; anaerobic ribonucleoside-triphosphate reductase activating protein 233320 nrdG 7685170 nrdG Streptococcus pneumoniae 70585 anaerobic ribonucleoside-triphosphate reductase activating protein YP_002739570.1 232730 D 488221 CDS YP_002739571.1 225858061 7683057 233317..233934 1 NC_012468.1 identified by match to protein family HMM PF00485; phosphoribulokinase / Uridine kinase family 233934 7683057 SP70585_0263 Streptococcus pneumoniae 70585 phosphoribulokinase / Uridine kinase family YP_002739571.1 233317 D 488221 CDS YP_002739572.1 225858062 7684985 234210..234518 1 NC_012468.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 234518 rpsJ 7684985 rpsJ Streptococcus pneumoniae 70585 30S ribosomal protein S10 YP_002739572.1 234210 D 488221 CDS YP_002739573.1 225858063 7685148 234735..235361 1 NC_012468.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 235361 rplC 7685148 rplC Streptococcus pneumoniae 70585 50S ribosomal protein L3 YP_002739573.1 234735 D 488221 CDS YP_002739574.1 225858064 7683417 235386..236009 1 NC_012468.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 236009 rplD 7683417 rplD Streptococcus pneumoniae 70585 50S ribosomal protein L4 YP_002739574.1 235386 D 488221 CDS YP_002739575.1 225858065 7683521 236009..236305 1 NC_012468.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 236305 rplW 7683521 rplW Streptococcus pneumoniae 70585 50S ribosomal protein L23 YP_002739575.1 236009 D 488221 CDS YP_002739576.1 225858066 7682978 236323..237156 1 NC_012468.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 237156 rplB 7682978 rplB Streptococcus pneumoniae 70585 50S ribosomal protein L2 YP_002739576.1 236323 D 488221 CDS YP_002739577.1 225858067 7683340 237260..237541 1 NC_012468.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 237541 rpsS 7683340 rpsS Streptococcus pneumoniae 70585 30S ribosomal protein S19 YP_002739577.1 237260 D 488221 CDS YP_002739578.1 225858068 7684326 237553..237897 1 NC_012468.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 237897 rplV 7684326 rplV Streptococcus pneumoniae 70585 50S ribosomal protein L22 YP_002739578.1 237553 D 488221 CDS YP_002739579.1 225858069 7683950 237910..238563 1 NC_012468.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 238563 rpsC 7683950 rpsC Streptococcus pneumoniae 70585 30S ribosomal protein S3 YP_002739579.1 237910 D 488221 CDS YP_002739580.1 225858070 7683981 238567..238980 1 NC_012468.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 238980 rplP 7683981 rplP Streptococcus pneumoniae 70585 50S ribosomal protein L16 YP_002739580.1 238567 D 488221 CDS YP_002739581.1 225858071 7684156 238990..239196 1 NC_012468.1 one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 239196 rpmC 7684156 rpmC Streptococcus pneumoniae 70585 50S ribosomal protein L29 YP_002739581.1 238990 D 488221 CDS YP_002739582.1 225858072 7684956 239221..239481 1 NC_012468.1 primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 239481 rpsQ 7684956 rpsQ Streptococcus pneumoniae 70585 30S ribosomal protein S17 YP_002739582.1 239221 D 488221 CDS YP_002739583.1 225858073 7683565 239507..239875 1 NC_012468.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 239875 rplN 7683565 rplN Streptococcus pneumoniae 70585 50S ribosomal protein L14 YP_002739583.1 239507 D 488221 CDS YP_002739584.1 225858074 7685030 239953..240258 1 NC_012468.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 240258 rplX 7685030 rplX Streptococcus pneumoniae 70585 50S ribosomal protein L24 YP_002739584.1 239953 D 488221 CDS YP_002739585.1 225858075 7684774 240282..240824 1 NC_012468.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 240824 rplE 7684774 rplE Streptococcus pneumoniae 70585 50S ribosomal protein L5 YP_002739585.1 240282 D 488221 CDS YP_002739586.1 225858076 7683603 240842..241111 1 NC_012468.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 241111 rpsN 7683603 rpsN Streptococcus pneumoniae 70585 30S ribosomal protein S14 YP_002739586.1 240842 D 488221 CDS YP_002739587.1 225858077 7682979 241396..241794 1 NC_012468.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 241794 rpsH 7682979 rpsH Streptococcus pneumoniae 70585 30S ribosomal protein S8 YP_002739587.1 241396 D 488221 CDS YP_002739588.1 225858078 7684895 241986..242522 1 NC_012468.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 242522 rplF 7684895 rplF Streptococcus pneumoniae 70585 50S ribosomal protein L6 YP_002739588.1 241986 D 488221 CDS YP_002739589.1 225858079 7684644 242606..242962 1 NC_012468.1 binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 242962 rplR 7684644 rplR Streptococcus pneumoniae 70585 50S ribosomal protein L18 YP_002739589.1 242606 D 488221 CDS YP_002739590.1 225858080 7684570 242980..243474 1 NC_012468.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 243474 rpsE 7684570 rpsE Streptococcus pneumoniae 70585 30S ribosomal protein S5 YP_002739590.1 242980 D 488221 CDS YP_002739591.1 225858081 7683249 243488..243670 1 NC_012468.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 243670 rpmD 7683249 rpmD Streptococcus pneumoniae 70585 50S ribosomal protein L30 YP_002739591.1 243488 D 488221 CDS YP_002739592.1 225858082 7684374 243815..244255 1 NC_012468.1 late assembly protein; 50S ribosomal protein L15 244255 rplO 7684374 rplO Streptococcus pneumoniae 70585 50S ribosomal protein L15 YP_002739592.1 243815 D 488221 CDS YP_002739593.1 225858083 7684587 244268..245578 1 NC_012468.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 245578 secY 7684587 secY Streptococcus pneumoniae 70585 preprotein translocase subunit SecY YP_002739593.1 244268 D 488221 CDS YP_002739594.1 225858084 7683594 245729..246367 1 NC_012468.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 246367 adk 7683594 adk Streptococcus pneumoniae 70585 adenylate kinase YP_002739594.1 245729 D 488221 CDS YP_002739595.1 225858085 7684702 246484..246702 1 NC_012468.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 246702 infA 7684702 infA Streptococcus pneumoniae 70585 translation initiation factor IF-1 YP_002739595.1 246484 D 488221 CDS YP_002739596.1 225858086 7683167 246727..246843 1 NC_012468.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 246843 rpmJ 7683167 rpmJ Streptococcus pneumoniae 70585 50S ribosomal protein L36 YP_002739596.1 246727 D 488221 CDS YP_002739597.1 225858087 7682998 246861..247226 1 NC_012468.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 247226 rpsM 7682998 rpsM Streptococcus pneumoniae 70585 30S ribosomal protein S13 YP_002739597.1 246861 D 488221 CDS YP_002739598.1 225858088 7684571 247244..247627 1 NC_012468.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 247627 rpsK 7684571 rpsK Streptococcus pneumoniae 70585 30S ribosomal protein S11 YP_002739598.1 247244 D 488221 CDS YP_002739599.1 225858089 7683569 247670..248605 1 NC_012468.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 248605 rpoA 7683569 rpoA Streptococcus pneumoniae 70585 DNA-directed RNA polymerase subunit alpha YP_002739599.1 247670 D 488221 CDS YP_002739600.1 225858090 7683204 248617..249003 1 NC_012468.1 is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 249003 rplQ 7683204 rplQ Streptococcus pneumoniae 70585 50S ribosomal protein L17 YP_002739600.1 248617 D 488221 CDS YP_002739601.1 225858091 7683823 249268..249534 1 NC_012468.1 ACT domain-containing protein; hypothetical protein 249534 7683823 SP70585_0293 Streptococcus pneumoniae 70585 hypothetical protein YP_002739601.1 249268 D 488221 CDS YP_002739602.1 225858092 7683582 249544..250881 1 NC_012468.1 identified by match to protein family HMM PF05167; hypothetical protein 250881 7683582 SP70585_0294 Streptococcus pneumoniae 70585 hypothetical protein YP_002739602.1 249544 D 488221 CDS YP_002739603.1 225858093 7684085 251125..251817 1 NC_012468.1 identified by match to protein family HMM PF00300; phosphoglycerate mutase family protein 251817 7684085 SP70585_0295 Streptococcus pneumoniae 70585 phosphoglycerate mutase family protein YP_002739603.1 251125 D 488221 CDS YP_002739604.1 225858094 7683867 complement(254649..255098) 1 NC_012468.1 iron ABC transporter iron-binding protein 255098 7683867 SP70585_0301 Streptococcus pneumoniae 70585 iron ABC transporter iron-binding protein YP_002739604.1 254649 R 488221 CDS YP_002739605.1 225858095 7684470 complement(255162..255356) 1 NC_012468.1 hypothetical protein 255356 7684470 SP70585_0302 Streptococcus pneumoniae 70585 hypothetical protein YP_002739605.1 255162 R 488221 CDS YP_002739606.1 225858096 7683857 complement(256742..257125) 1 NC_012468.1 Two-component sensor kinase YesM 257125 7683857 SP70585_0306 Streptococcus pneumoniae 70585 Two-component sensor kinase YesM YP_002739606.1 256742 R 488221 CDS YP_002739607.1 225858097 7684729 complement(257458..258234) 1 NC_012468.1 identified by match to protein family HMM PF04055; match to protein family HMM TIGR02494; pyruvate formate-lyase 3 258234 7684729 SP70585_0307 Streptococcus pneumoniae 70585 pyruvate formate-lyase 3 YP_002739607.1 257458 R 488221 CDS YP_002739608.1 225858098 7684355 258356..259102 1 NC_012468.1 identified by match to protein family HMM PF00455; match to protein family HMM PF08220; match to protein family HMM PF08279; putative HTH-type transcriptional regulator YciT 259102 7684355 SP70585_0308 Streptococcus pneumoniae 70585 putative HTH-type transcriptional regulator YciT YP_002739608.1 258356 D 488221 CDS YP_002739609.1 225858099 7683140 259115..260095 1 NC_012468.1 identified by match to protein family HMM PF04198; transcriptional regulator 260095 7683140 SP70585_0309 Streptococcus pneumoniae 70585 transcriptional regulator YP_002739609.1 259115 D 488221 CDS YP_002739610.1 225858100 7685115 260290..260610 1 NC_012468.1 identified by match to protein family HMM PF02255; phosphotransferase system sugar-specific eiia component 260610 7685115 SP70585_0310 Streptococcus pneumoniae 70585 phosphotransferase system sugar-specific eiia component YP_002739610.1 260290 D 488221 CDS YP_002739611.1 225858101 7683106 260656..260964 1 NC_012468.1 identified by match to protein family HMM PF02302; phosphotransferase system sugar-specific eiib component 260964 7683106 SP70585_0311 Streptococcus pneumoniae 70585 phosphotransferase system sugar-specific eiib component YP_002739611.1 260656 D 488221 CDS YP_002739612.1 225858102 7684203 260981..262279 1 NC_012468.1 identified by match to protein family HMM PF02378; match to protein family HMM TIGR00410; lichenan permease iic component (pts system lichenan-specific eiiccomponent) (eiic-lic) 262279 7684203 SP70585_0312 Streptococcus pneumoniae 70585 lichenan permease iic component (pts system lichenan-specific eiiccomponent) (eiic-lic) YP_002739612.1 260981 D 488221 CDS YP_002739613.1 225858103 7684043 262430..264868 1 NC_012468.1 identified by match to protein family HMM PF01228; match to protein family HMM PF02901; match to protein family HMM TIGR01774; pyruvate formate-lyase 264868 7684043 SP70585_0313 Streptococcus pneumoniae 70585 pyruvate formate-lyase YP_002739613.1 262430 D 488221 CDS YP_002739614.1 225858104 7683633 264887..265555 1 NC_012468.1 similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase 265555 7683633 SP70585_0314 Streptococcus pneumoniae 70585 fructose-6-phosphate aldolase YP_002739614.1 264887 D 488221 CDS YP_002739615.1 225858105 7684748 265573..266661 1 NC_012468.1 forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone; glycerol dehydrogenase 266661 gldA 7684748 gldA Streptococcus pneumoniae 70585 glycerol dehydrogenase YP_002739615.1 265573 D 488221 CDS YP_002739616.1 225858106 7683263 267116..269617 1 NC_012468.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 269617 leuS 7683263 leuS Streptococcus pneumoniae 70585 leucyl-tRNA synthetase YP_002739616.1 267116 D 488221 CDS YP_002739617.1 225858107 7682896 269811..270506 1 NC_012468.1 identified by match to protein family HMM PF00583; acetyltransferase, gnat family 270506 7682896 SP70585_0317 Streptococcus pneumoniae 70585 acetyltransferase, gnat family YP_002739617.1 269811 D 488221 CDS YP_002739618.1 225858108 7684645 270518..270934 1 NC_012468.1 identified by match to protein family HMM PF00583; acetyltransferase, gnat family 270934 7684645 SP70585_0318 Streptococcus pneumoniae 70585 acetyltransferase, gnat family YP_002739618.1 270518 D 488221 CDS YP_002739619.1 225858109 7684821 271975..272973 1 NC_012468.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 272973 ruvB 7684821 ruvB Streptococcus pneumoniae 70585 Holliday junction DNA helicase RuvB YP_002739619.1 271975 D 488221 CDS YP_002739620.1 225858110 7683255 272954..273526 1 NC_012468.1 identified by match to protein family HMM PF06042; hypothetical protein 273526 7683255 SP70585_0320 Streptococcus pneumoniae 70585 hypothetical protein YP_002739620.1 272954 D 488221 CDS YP_002739621.1 225858111 7683246 273757..274515 1 NC_012468.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; UDP pyrophosphate synthase 274515 uppS 7683246 uppS Streptococcus pneumoniae 70585 UDP pyrophosphate synthase YP_002739621.1 273757 D 488221 CDS YP_002739622.1 225858112 7682882 274524..275327 1 NC_012468.1 identified by match to protein family HMM PF01148; phosphatidate cytidylyltransferase 275327 cdsA 7682882 cdsA Streptococcus pneumoniae 70585 phosphatidate cytidylyltransferase YP_002739622.1 274524 D 488221 CDS YP_002739623.1 225858113 7684480 275349..276608 1 NC_012468.1 identified by match to protein family HMM PF02163; match to protein family HMM TIGR00054; RIP metalloprotease RseP 276608 rseP 7684480 rseP Streptococcus pneumoniae 70585 RIP metalloprotease RseP YP_002739623.1 275349 D 488221 CDS YP_002739624.1 225858114 7683030 276621..278474 1 NC_012468.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 278474 proS 7683030 proS Streptococcus pneumoniae 70585 prolyl-tRNA synthetase YP_002739624.1 276621 D 488221 CDS YP_002739625.1 225858115 7684058 278573..279952 1 NC_012468.1 identified by match to protein family HMM PF00232; glycosyl hydrolase, family 1 279952 7684058 SP70585_0325 Streptococcus pneumoniae 70585 glycosyl hydrolase, family 1 YP_002739625.1 278573 D 488221 CDS YP_002739626.1 225858116 7683988 280145..281953 1 NC_012468.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 281953 glmS 7683988 glmS Streptococcus pneumoniae 70585 glucosamine--fructose-6-phosphate aminotransferase YP_002739626.1 280145 D 488221 CDS YP_002739627.1 225858117 7683230 282072..283121 1 NC_012468.1 identified by match to protein family HMM PF00296; oxidoreductase 283121 7683230 SP70585_0327 Streptococcus pneumoniae 70585 oxidoreductase YP_002739627.1 282072 D 488221 CDS YP_002739628.1 225858118 7682897 complement(283221..287063) 1 NC_012468.1 identified by match to protein family HMM PF00128; match to protein family HMM PF00746; match to protein family HMM PF02922; match to protein family HMM PF03714; match to protein family HMM PF04650; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; match to protein family HMM TIGR02102; pullulanase, extracellular 287063 7682897 SP70585_0328 Streptococcus pneumoniae 70585 pullulanase, extracellular YP_002739628.1 283221 R 488221 CDS YP_002739629.1 225858119 7682887 287480..287893 1 NC_012468.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 287893 rpsL 7682887 rpsL Streptococcus pneumoniae 70585 30S ribosomal protein S12 YP_002739629.1 287480 D 488221 CDS YP_002739630.1 225858120 7684912 287913..288383 1 NC_012468.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 288383 rpsG 7684912 rpsG Streptococcus pneumoniae 70585 30S ribosomal protein S7 YP_002739630.1 287913 D 488221 CDS YP_002739631.1 225858121 7685054 288808..290889 1 NC_012468.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 290889 fusA 7685054 fusA Streptococcus pneumoniae 70585 elongation factor G YP_002739631.1 288808 D 488221 CDS YP_002739632.1 225858122 7684418 290993..295384 1 NC_012468.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; required for leading strand synthesis; PolC exhibits 3' to 5' exonuclease activity; DNA polymerase III PolC 295384 polC 7684418 polC Streptococcus pneumoniae 70585 DNA polymerase III PolC YP_002739632.1 290993 D 488221 CDS YP_002739633.1 225858123 7683006 295486..295749 1 NC_012468.1 identified by match to protein family HMM PF04221; match to protein family HMM TIGR02384; addiction module antitoxin, RelB/DinJ family 295749 7683006 SP70585_0333 Streptococcus pneumoniae 70585 addiction module antitoxin, RelB/DinJ family YP_002739633.1 295486 D 488221 CDS YP_002739634.1 225858124 7684189 295787..296020 1 NC_012468.1 identified by match to protein family HMM PF05016; match to protein family HMM TIGR02385; DNA damage inducible protein 296020 7684189 SP70585_0334 Streptococcus pneumoniae 70585 DNA damage inducible protein YP_002739634.1 295787 D 488221 CDS YP_002739635.1 225858125 7684892 296041..296193 1 NC_012468.1 hypothetical protein 296193 7684892 SP70585_0335 Streptococcus pneumoniae 70585 hypothetical protein YP_002739635.1 296041 D 488221 CDS YP_002739636.1 225858126 7683105 296215..297456 1 NC_012468.1 identified by match to protein family HMM PF02073; aminopeptidase PepS 297456 7683105 SP70585_0336 Streptococcus pneumoniae 70585 aminopeptidase PepS YP_002739636.1 296215 D 488221 CDS YP_002739637.1 225858127 7683932 297466..297696 1 NC_012468.1 identified by match to protein family HMM PF04226; integral membrane protein 297696 7683932 SP70585_0337 Streptococcus pneumoniae 70585 integral membrane protein YP_002739637.1 297466 D 488221 CDS YP_002739638.1 225858128 7682952 complement(297701..297853) 1 NC_012468.1 hypothetical protein 297853 7682952 SP70585_0338 Streptococcus pneumoniae 70585 hypothetical protein YP_002739638.1 297701 R 488221 CDS YP_002739639.1 225858129 7684329 297964..298686 1 NC_012468.1 identified by match to protein family HMM PF00849; match to protein family HMM PF01479; match to protein family HMM TIGR00093; ribosomal small subunit pseudouridine synthase A, putative 298686 7684329 SP70585_0339 Streptococcus pneumoniae 70585 ribosomal small subunit pseudouridine synthase A, putative YP_002739639.1 297964 D 488221 CDS YP_002739640.1 225858130 7683760 298903..300237 1 NC_012468.1 identified by match to protein family HMM PF03051; aminopeptidase C (Bleomycin hydrolase) 300237 7683760 SP70585_0340 Streptococcus pneumoniae 70585 aminopeptidase C (Bleomycin hydrolase) YP_002739640.1 298903 D 488221 CDS YP_002739641.1 225858131 7683089 complement(300293..301204) 1 NC_012468.1 identified by match to protein family HMM PF03613; match to protein family HMM TIGR00828; PTS system, mannose/fructose/sorbose family, IID component 301204 7683089 SP70585_0341 Streptococcus pneumoniae 70585 PTS system, mannose/fructose/sorbose family, IID component YP_002739641.1 300293 R 488221 CDS YP_002739642.1 225858132 7684787 complement(301228..302031) 1 NC_012468.1 identified by match to protein family HMM PF03609; PTS system sorbose-specific IIC component 302031 7684787 SP70585_0342 Streptococcus pneumoniae 70585 PTS system sorbose-specific IIC component YP_002739642.1 301228 R 488221 CDS YP_002739643.1 225858133 7685118 complement(302059..303048) 1 NC_012468.1 identified by match to protein family HMM PF03610; match to protein family HMM PF03830; mannose-specific phosphotransferase system component iiab 303048 7685118 SP70585_0343 Streptococcus pneumoniae 70585 mannose-specific phosphotransferase system component iiab YP_002739643.1 302059 R 488221 CDS YP_002739644.1 225858134 7684094 complement(303282..304301) 1 NC_012468.1 similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs; alcohol dehydrogenase 304301 7684094 SP70585_0344 Streptococcus pneumoniae 70585 alcohol dehydrogenase YP_002739644.1 303282 R 488221 CDS YP_002739645.1 225858135 7684558 complement(304643..305455) 1 NC_012468.1 identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; Cof family protein 305455 7684558 SP70585_0345 Streptococcus pneumoniae 70585 Cof family protein YP_002739645.1 304643 R 488221 CDS YP_002739646.1 225858136 7684833 305645..307063 1 NC_012468.1 identified by match to protein family HMM PF00860; xanthine/uracil permease family protein 307063 7684833 SP70585_0346 Streptococcus pneumoniae 70585 xanthine/uracil permease family protein YP_002739646.1 305645 D 488221 CDS YP_002739647.1 225858137 7684526 307116..307823 1 NC_012468.1 identified by match to protein family HMM PF02517; caax amino protease family protein 307823 7684526 SP70585_0347 Streptococcus pneumoniae 70585 caax amino protease family protein YP_002739647.1 307116 D 488221 CDS YP_002739648.1 225858138 7683698 307917..308897 1 NC_012468.1 identified by match to protein family HMM PF00809; match to protein family HMM TIGR01496; dihydropteroate synthase 308897 folP 7683698 folP Streptococcus pneumoniae 70585 dihydropteroate synthase YP_002739648.1 307917 D 488221 CDS YP_002739649.1 225858139 7683655 308899..310221 1 NC_012468.1 identified by match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01499; dihydrofolate synthetase 310221 7683655 SP70585_0349 Streptococcus pneumoniae 70585 dihydrofolate synthetase YP_002739649.1 308899 D 488221 CDS YP_002739650.1 225858140 7683936 310202..310756 1 NC_012468.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 310756 folE 7683936 folE Streptococcus pneumoniae 70585 GTP cyclohydrolase I YP_002739650.1 310202 D 488221 CDS YP_002739651.1 225858141 7684117 310799..311611 1 NC_012468.1 identified by match to protein family HMM PF01288; match to protein family HMM PF02152; match to protein family HMM TIGR00525; match to protein family HMM TIGR00526; match to protein family HMM TIGR01498; bifunctional folate synthesis protein 311611 7684117 SP70585_0351 Streptococcus pneumoniae 70585 bifunctional folate synthesis protein YP_002739651.1 310799 D 488221 CDS YP_002739652.1 225858142 7684275 complement(311656..311973) 1 NC_012468.1 hypothetical protein 311973 7684275 SP70585_0352 Streptococcus pneumoniae 70585 hypothetical protein YP_002739652.1 311656 R 488221 CDS YP_002739653.1 225858143 7683320 312329..312775 1 NC_012468.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 312775 rplM 7683320 rplM Streptococcus pneumoniae 70585 50S ribosomal protein L13 YP_002739653.1 312329 D 488221 CDS YP_002739654.1 225858144 7684754 312794..313186 1 NC_012468.1 forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 313186 rpsI 7684754 rpsI Streptococcus pneumoniae 70585 30S ribosomal protein S9 YP_002739654.1 312794 D 488221 CDS YP_002739655.1 225858145 7684073 complement(313449..314327) 1 NC_012468.1 identified by match to protein family HMM PF00589; integrase/recombinase, phage integrase family 314327 7684073 SP70585_0355 Streptococcus pneumoniae 70585 integrase/recombinase, phage integrase family YP_002739655.1 313449 R 488221 CDS YP_002739656.1 225858146 7683820 complement(314569..315258) 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 315258 7683820 SP70585_0356 Streptococcus pneumoniae 70585 hypothetical protein YP_002739656.1 314569 R 488221 CDS YP_002739657.1 225858147 7683938 complement(315345..315755) 1 NC_012468.1 hypothetical protein 315755 7683938 SP70585_0357 Streptococcus pneumoniae 70585 hypothetical protein YP_002739657.1 315345 R 488221 CDS YP_002739658.1 225858148 7684106 complement(315812..316702) 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 316702 7684106 SP70585_0358 Streptococcus pneumoniae 70585 hypothetical protein YP_002739658.1 315812 R 488221 CDS YP_002739659.1 225858149 7682941 316905..317024 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 317024 7682941 SP70585_0359 Streptococcus pneumoniae 70585 hypothetical protein YP_002739659.1 316905 D 488221 CDS YP_002739660.1 225858150 7684939 317025..318116 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 318116 7684939 SP70585_0360 Streptococcus pneumoniae 70585 hypothetical protein YP_002739660.1 317025 D 488221 CDS YP_002739661.1 225858151 7683723 complement(318671..318892) 1 NC_012468.1 integrase/recombinase, phage integrase family 318892 7683723 SP70585_0361 Streptococcus pneumoniae 70585 integrase/recombinase, phage integrase family YP_002739661.1 318671 R 488221 CDS YP_002739662.1 225858152 7684973 complement(318997..319128) 1 NC_012468.1 hypothetical protein 319128 7684973 SP70585_0362 Streptococcus pneumoniae 70585 hypothetical protein YP_002739662.1 318997 R 488221 CDS YP_002739663.1 225858153 7684604 complement(319448..320656) 1 NC_012468.1 ATPase 320656 7684604 SP70585_0363 Streptococcus pneumoniae 70585 ATPase YP_002739663.1 319448 R 488221 CDS YP_002739664.1 225858154 7683399 320785..321132 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01710; transposase 321132 7683399 SP70585_0364 Streptococcus pneumoniae 70585 transposase YP_002739664.1 320785 D 488221 CDS YP_002739665.1 225858155 7683763 321330..321473 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; Spn1, transposase Orf2 321473 7683763 SP70585_0365 Streptococcus pneumoniae 70585 Spn1, transposase Orf2 YP_002739665.1 321330 D 488221 CDS YP_002739666.1 225858156 7683428 321493..321612 1 NC_012468.1 hypothetical protein 321612 7683428 SP70585_0366 Streptococcus pneumoniae 70585 hypothetical protein YP_002739666.1 321493 D 488221 CDS YP_002739667.1 225858157 7685083 321802..323238 1 NC_012468.1 converts 6-phospho-beta-D-glucosyl-(1,4)-D-glucose to glucose and glucose 6-phosphate; required for cellobiose uptake and metabolism; 6-phospho-beta-glucosidase 323238 celA 7685083 celA Streptococcus pneumoniae 70585 6-phospho-beta-glucosidase YP_002739667.1 321802 D 488221 CDS YP_002739668.1 225858158 7684208 323290..323529 1 NC_012468.1 identified by match to protein family HMM PF03083; glutathione synthetase 323529 7684208 SP70585_0368 Streptococcus pneumoniae 70585 glutathione synthetase YP_002739668.1 323290 D 488221 CDS YP_002739669.1 225858159 7683021 323659..323973 1 NC_012468.1 required for cellobiose uptake and metabolism; cellobiose phosphotransferase system IIB component 323973 celB 7683021 celB Streptococcus pneumoniae 70585 cellobiose phosphotransferase system IIB component YP_002739669.1 323659 D 488221 CDS YP_002739670.1 225858160 7684158 324097..326070 1 NC_012468.1 identified by match to protein family HMM PF00874; match to protein family HMM PF05043; match to protein family HMM PF08279; transcription antiterminator BglG family 326070 7684158 SP70585_0370 Streptococcus pneumoniae 70585 transcription antiterminator BglG family YP_002739670.1 324097 D 488221 CDS YP_002739671.1 225858161 7684255 326080..326394 1 NC_012468.1 required for cellobiose uptake and metabolism; cellobiose phosphotransferase system IIA component 326394 celC 7684255 celC Streptococcus pneumoniae 70585 cellobiose phosphotransferase system IIA component YP_002739671.1 326080 D 488221 CDS YP_002739672.1 225858162 7683479 326425..326931 1 NC_012468.1 hypothetical protein 326931 7683479 SP70585_0372 Streptococcus pneumoniae 70585 hypothetical protein YP_002739672.1 326425 D 488221 CDS YP_002739673.1 225858163 7683968 327011..328357 1 NC_012468.1 required for cellobiose uptake and metabolism; cellobiose phosphotransferase system IIC component 328357 celD 7683968 celD Streptococcus pneumoniae 70585 cellobiose phosphotransferase system IIC component YP_002739673.1 327011 D 488221 CDS YP_002739674.1 225858164 7684356 328737..328913 1 NC_012468.1 hypothetical protein 328913 7684356 SP70585_0374 Streptococcus pneumoniae 70585 hypothetical protein YP_002739674.1 328737 D 488221 CDS YP_002739675.1 225858165 7683211 329315..331528 1 NC_012468.1 identified by match to protein family HMM PF01055; glycosyl hydrolase, family 31 331528 7683211 SP70585_0375 Streptococcus pneumoniae 70585 glycosyl hydrolase, family 31 YP_002739675.1 329315 D 488221 CDS YP_002739676.1 225858166 7683098 complement(331554..331931) 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01609; transposase (IS4 family) 331931 7683098 SP70585_0376 Streptococcus pneumoniae 70585 transposase (IS4 family) YP_002739676.1 331554 R 488221 CDS YP_002739677.1 225858167 7683839 complement(331943..332404) 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase 332404 7683839 SP70585_0377 Streptococcus pneumoniae 70585 transposase YP_002739677.1 331943 R 488221 CDS YP_002739678.1 225858168 7685101 complement(332623..333099) 1 NC_012468.1 identified by match to protein family HMM PF00255; peroxiredoxin Hyr1 (hydrogen peroxide resistanceprotein 1) (oxidant receptor peroxidase 1) (glutathione peroxidase 3)(phospholipid hydroperoxide glutathione peroxidase 3) (phgpx3) 333099 7685101 SP70585_0378 Streptococcus pneumoniae 70585 peroxiredoxin Hyr1 (hydrogen peroxide resistanceprotein 1) (oxidant receptor peroxidase 1) (glutathione peroxidase 3)(phospholipid hydroperoxide glutathione peroxidase 3) (phgpx3) YP_002739678.1 332623 R 488221 CDS YP_002739679.1 225858169 7684408 333322..336525 1 NC_012468.1 identified by match to protein family HMM PF00746; match to protein family HMM PF02018; match to protein family HMM PF02278; match to protein family HMM PF02884; match to protein family HMM PF08124; match to protein family HMM TIGR01167; hyaluronate lyase 336525 7684408 SP70585_0379 Streptococcus pneumoniae 70585 hyaluronate lyase YP_002739679.1 333322 D 488221 CDS YP_002739680.1 225858170 7683060 336939..337292 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase 337292 7683060 SP70585_0380 Streptococcus pneumoniae 70585 transposase YP_002739680.1 336939 D 488221 CDS YP_002739681.1 225858171 7684966 complement(337668..338297) 1 NC_012468.1 catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase 338297 7684966 SP70585_0381 Streptococcus pneumoniae 70585 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase YP_002739681.1 337668 R 488221 CDS YP_002739682.1 225858172 7684200 complement(338307..339308) 1 NC_012468.1 identified by match to protein family HMM PF00294; 2-keto-3-deoxygluconate kinase 339308 7684200 SP70585_0382 Streptococcus pneumoniae 70585 2-keto-3-deoxygluconate kinase YP_002739682.1 338307 R 488221 CDS YP_002739683.1 225858173 7683420 complement(339339..339980) 1 NC_012468.1 identified by match to protein family HMM PF02502; hypothetical protein 339980 7683420 SP70585_0383 Streptococcus pneumoniae 70585 hypothetical protein YP_002739683.1 339339 R 488221 CDS YP_002739684.1 225858174 7683955 complement(339999..340814) 1 NC_012468.1 Involved in the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate; gluconate 5-dehydrogenase 340814 7683955 SP70585_0384 Streptococcus pneumoniae 70585 gluconate 5-dehydrogenase YP_002739684.1 339999 R 488221 CDS YP_002739685.1 225858175 7684722 341086..341520 1 NC_012468.1 identified by match to protein family HMM PF03610; phosphotransferase system sugar-specific EII component 341520 7684722 SP70585_0385 Streptococcus pneumoniae 70585 phosphotransferase system sugar-specific EII component YP_002739685.1 341086 D 488221 CDS YP_002739686.1 225858176 7684278 341532..342722 1 NC_012468.1 identified by match to protein family HMM PF07470; unsaturated glucuronyl hydrolase (UGL) (Glycuronidase)(Unsaturated uronic acid hydrolase) (Glycosaminoglycan hydrolase) 342722 7684278 SP70585_0386 Streptococcus pneumoniae 70585 unsaturated glucuronyl hydrolase (UGL) (Glycuronidase)(Unsaturated uronic acid hydrolase) (Glycosaminoglycan hydrolase) YP_002739686.1 341532 D 488221 CDS YP_002739687.1 225858177 7683048 342733..343224 1 NC_012468.1 identified by match to protein family HMM PF03830; N-acetylgalactosamine-specific phosphotransferase enzyme iib component2 (pts system n-acetylgalactosamine-specific eiibcomponent 2) (eiib-aga') 343224 7683048 SP70585_0387 Streptococcus pneumoniae 70585 N-acetylgalactosamine-specific phosphotransferase enzyme iib component2 (pts system n-acetylgalactosamine-specific eiibcomponent 2) (eiib-aga') YP_002739687.1 342733 D 488221 CDS YP_002739688.1 225858178 7683556 343239..344018 1 NC_012468.1 identified by match to protein family HMM PF03609; phosphotransferase system sugar-specific EII component 344018 7683556 SP70585_0388 Streptococcus pneumoniae 70585 phosphotransferase system sugar-specific EII component YP_002739688.1 343239 D 488221 CDS YP_002739689.1 225858179 7682959 344005..344823 1 NC_012468.1 identified by match to protein family HMM PF03613; PTS system, IID component 344823 7682959 SP70585_0389 Streptococcus pneumoniae 70585 PTS system, IID component YP_002739689.1 344005 D 488221 CDS YP_002739690.1 225858180 7683322 344859..345116 1 NC_012468.1 preprotein translocase, YajC subunit 345116 7683322 SP70585_0390 Streptococcus pneumoniae 70585 preprotein translocase, YajC subunit YP_002739690.1 344859 D 488221 CDS YP_002739691.1 225858181 7683365 345138..347039 1 NC_012468.1 identified by match to protein family HMM PF07940; oligohyaluronate lyase 347039 7683365 SP70585_0391 Streptococcus pneumoniae 70585 oligohyaluronate lyase YP_002739691.1 345138 D 488221 CDS YP_002739692.1 225858182 7684114 347099..348100 1 NC_012468.1 identified by match to protein family HMM PF00356; match to protein family HMM PF00532; sugar binding transcriptional regulator RegR 348100 7684114 SP70585_0392 Streptococcus pneumoniae 70585 sugar binding transcriptional regulator RegR YP_002739692.1 347099 D 488221 CDS YP_002739693.1 225858183 7682963 complement(348210..348545) 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 348545 7682963 SP70585_0393 Streptococcus pneumoniae 70585 hypothetical protein YP_002739693.1 348210 R 488221 CDS YP_002739694.1 225858184 7685196 complement(348556..348798) 1 NC_012468.1 hypothetical protein 348798 7685196 SP70585_0394 Streptococcus pneumoniae 70585 hypothetical protein YP_002739694.1 348556 R 488221 CDS YP_002739695.1 225858185 7684847 complement(348809..349351) 1 NC_012468.1 hypothetical protein 349351 7684847 SP70585_0395 Streptococcus pneumoniae 70585 hypothetical protein YP_002739695.1 348809 R 488221 CDS YP_002739696.1 225858186 7685125 complement(349367..349561) 1 NC_012468.1 identified by match to protein family HMM PF01381; hypothetical protein 349561 7685125 SP70585_0396 Streptococcus pneumoniae 70585 hypothetical protein YP_002739696.1 349367 R 488221 CDS YP_002739697.1 225858187 7683559 349727..350677 1 NC_012468.1 identified by match to protein family HMM PF01795; match to protein family HMM TIGR00006; S-adenosyl-methyltransferase MraW 350677 mraW 7683559 mraW Streptococcus pneumoniae 70585 S-adenosyl-methyltransferase MraW YP_002739697.1 349727 D 488221 CDS YP_002739698.1 225858188 7684555 350689..351006 1 NC_012468.1 identified by match to protein family HMM TIGR02209; cell division protein FtsL 351006 ftsL 7684555 ftsL Streptococcus pneumoniae 70585 cell division protein FtsL YP_002739698.1 350689 D 488221 CDS YP_002739699.1 225858189 7684717 351010..353262 1 NC_012468.1 identified by match to protein family HMM PF00905; match to protein family HMM PF03717; match to protein family HMM PF03793; penicillin-binding protein 2X 353262 7684717 SP70585_0399 Streptococcus pneumoniae 70585 penicillin-binding protein 2X YP_002739699.1 351010 D 488221 CDS YP_002739700.1 225858190 7683384 353264..354244 1 NC_012468.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 354244 mraY 7683384 mraY Streptococcus pneumoniae 70585 phospho-N-acetylmuramoyl-pentapeptide- transferase YP_002739700.1 353264 D 488221 CDS YP_002739701.1 225858191 7684366 354456..354572 1 NC_012468.1 hypothetical protein 354572 7684366 SP70585_0401 Streptococcus pneumoniae 70585 hypothetical protein YP_002739701.1 354456 D 488221 CDS YP_002739702.1 225858192 7684926 354853..356958 1 NC_012468.1 identified by match to protein family HMM PF00004; match to protein family HMM PF07724; match to protein family HMM PF07728; ATP-dependent Clp protease ATP-binding subunit ClpL 356958 7684926 SP70585_0402 Streptococcus pneumoniae 70585 ATP-dependent Clp protease ATP-binding subunit ClpL YP_002739702.1 354853 D 488221 CDS YP_002739703.1 225858193 7684636 357464..357745 1 NC_012468.1 GBSi1, group II intron, maturase 357745 7684636 SP70585_0403 Streptococcus pneumoniae 70585 GBSi1, group II intron, maturase YP_002739703.1 357464 D 488221 CDS YP_002739704.1 225858194 7684294 complement(357812..358294) 1 NC_012468.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase 358294 luxS 7684294 luxS Streptococcus pneumoniae 70585 S-ribosylhomocysteinase YP_002739704.1 357812 R 488221 CDS YP_002739705.1 225858195 7683148 complement(358389..359873) 1 NC_012468.1 identified by match to protein family HMM PF08903; hypothetical protein 359873 7683148 SP70585_0405 Streptococcus pneumoniae 70585 hypothetical protein YP_002739705.1 358389 R 488221 CDS YP_002739706.1 225858196 7684838 360026..361633 1 NC_012468.1 identified by match to protein family HMM PF00128; trehalose-6-phosphate hydrolase (Alpha,alpha-phosphotrehalase) 361633 7684838 SP70585_0406 Streptococcus pneumoniae 70585 trehalose-6-phosphate hydrolase (Alpha,alpha-phosphotrehalase) YP_002739706.1 360026 D 488221 CDS YP_002739707.1 225858197 7685110 361792..361965 1 NC_012468.1 lipoprotein, putative 361965 7685110 SP70585_0408 Streptococcus pneumoniae 70585 lipoprotein, putative YP_002739707.1 361792 D 488221 CDS YP_002739708.1 225858198 7684409 complement(361958..362140) 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase 362140 7684409 SP70585_0407 Streptococcus pneumoniae 70585 transposase YP_002739708.1 361958 R 488221 CDS YP_002739709.1 225858199 7684405 362188..362313 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 362313 7684405 SP70585_0409 Streptococcus pneumoniae 70585 hypothetical protein YP_002739709.1 362188 D 488221 CDS YP_002739710.1 225858200 7683242 complement(362479..362826) 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01710; Spn1 transposase 362826 7683242 SP70585_0410 Streptococcus pneumoniae 70585 Spn1 transposase YP_002739710.1 362479 R 488221 CDS YP_002739711.1 225858201 7683138 362849..363310 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase 363310 7683138 SP70585_0411 Streptococcus pneumoniae 70585 transposase YP_002739711.1 362849 D 488221 CDS YP_002739712.1 225858202 7685052 363322..363699 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01609; transposase (IS4 family) 363699 7685052 SP70585_0412 Streptococcus pneumoniae 70585 transposase (IS4 family) YP_002739712.1 363322 D 488221 CDS YP_002739713.1 225858203 7684984 363930..365375 1 NC_012468.1 identified by match to protein family HMM PF02916; match to protein family HMM PF03816; match to protein family HMM TIGR00350; integral membrane regulatory protein Wzg 365375 7684984 SP70585_0413 Streptococcus pneumoniae 70585 integral membrane regulatory protein Wzg YP_002739713.1 363930 D 488221 CDS YP_002739714.1 225858204 7683705 365377..366108 1 NC_012468.1 identified by match to protein family HMM PF02811; tyrosine-protein phosphatase CpsB 366108 7683705 SP70585_0414 Streptococcus pneumoniae 70585 tyrosine-protein phosphatase CpsB YP_002739714.1 365377 D 488221 CDS YP_002739715.1 225858205 7683674 366117..366809 1 NC_012468.1 identified by match to protein family HMM PF02706; match to protein family HMM TIGR01006; capsular polysaccharide biosynthesis protein Wzd 366809 7683674 SP70585_0415 Streptococcus pneumoniae 70585 capsular polysaccharide biosynthesis protein Wzd YP_002739715.1 366117 D 488221 CDS YP_002739716.1 225858206 7684146 366819..367493 1 NC_012468.1 identified by match to protein family HMM TIGR01007; tyrosine-protein kinase CpsD 367493 7684146 SP70585_0416 Streptococcus pneumoniae 70585 tyrosine-protein kinase CpsD YP_002739716.1 366819 D 488221 CDS YP_002739717.1 225858207 7683406 367897..368490 1 NC_012468.1 identified by match to protein family HMM PF02397; capsular polysaccharide biosynthesis protein Cps4E 368490 7683406 SP70585_0417 Streptococcus pneumoniae 70585 capsular polysaccharide biosynthesis protein Cps4E YP_002739717.1 367897 D 488221 CDS YP_002739718.1 225858208 7683729 368499..369725 1 NC_012468.1 identified by match to protein family HMM PF00534; capsular polysaccharide biosynthesis protein Cps4F 369725 7683729 SP70585_0418 Streptococcus pneumoniae 70585 capsular polysaccharide biosynthesis protein Cps4F YP_002739718.1 368499 D 488221 CDS YP_002739719.1 225858209 7683459 369956..371161 1 NC_012468.1 putative repeating unit polymerase 371161 7683459 SP70585_0419 Streptococcus pneumoniae 70585 putative repeating unit polymerase YP_002739719.1 369956 D 488221 CDS YP_002739720.1 225858210 7684197 371139..372608 1 NC_012468.1 identified by match to protein family HMM PF01943; match to protein family HMM PF03023; flippase Wzx 372608 7684197 SP70585_0420 Streptococcus pneumoniae 70585 flippase Wzx YP_002739720.1 371139 D 488221 CDS YP_002739721.1 225858211 7684242 372605..373486 1 NC_012468.1 identified by match to protein family HMM PF00535; putative glycosyl transferase 373486 7684242 SP70585_0421 Streptococcus pneumoniae 70585 putative glycosyl transferase YP_002739721.1 372605 D 488221 CDS YP_002739722.1 225858212 7684131 373500..374585 1 NC_012468.1 identified by match to protein family HMM PF00534; putative glycosyltransferase 374585 7684131 SP70585_0422 Streptococcus pneumoniae 70585 putative glycosyltransferase YP_002739722.1 373500 D 488221 CDS YP_002739723.1 225858213 7684497 374578..375384 1 NC_012468.1 hypothetical protein 375384 7684497 SP70585_0423 Streptococcus pneumoniae 70585 hypothetical protein YP_002739723.1 374578 D 488221 CDS YP_002739724.1 225858214 7683551 375618..376655 1 NC_012468.1 identified by match to protein family HMM PF00106; match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF04321; match to protein family HMM PF07993; match to protein family HMM PF08485; trifunctional UDP-D-GlcNAc 4,6-dehdratase/5-epimerase/3-epimerase 376655 7683551 SP70585_0424 Streptococcus pneumoniae 70585 trifunctional UDP-D-GlcNAc 4,6-dehdratase/5-epimerase/3-epimerase YP_002739724.1 375618 D 488221 CDS YP_002739725.1 225858215 7683885 376664..377875 1 NC_012468.1 identified by match to protein family HMM PF00984; match to protein family HMM PF01210; match to protein family HMM PF03720; match to protein family HMM PF03721; match to protein family HMM TIGR03026; UDP-glucose 6-dehydrogenase 377875 ugd 7683885 ugd Streptococcus pneumoniae 70585 UDP-glucose 6-dehydrogenase YP_002739725.1 376664 D 488221 CDS YP_002739726.1 225858216 7685187 377894..379123 1 NC_012468.1 identified by match to protein family HMM PF01370; match to protein family HMM PF07993; UDP-2-acetamido-2,6-dideoxy-b-L-lyxo-4-hexulose 4-reductase 379123 7685187 SP70585_0426 Streptococcus pneumoniae 70585 UDP-2-acetamido-2,6-dideoxy-b-L-lyxo-4-hexulose 4-reductase YP_002739726.1 377894 D 488221 CDS YP_002739727.1 225858217 7684395 379124..380308 1 NC_012468.1 identified by match to protein family HMM PF02350; match to protein family HMM TIGR00236; UDP-N-acetylglucosamine 2-epimerase 380308 7684395 SP70585_0427 Streptococcus pneumoniae 70585 UDP-N-acetylglucosamine 2-epimerase YP_002739727.1 379124 D 488221 CDS YP_002739728.1 225858218 7684559 380704..380889 1 NC_012468.1 IS66 family element 380889 7684559 SP70585_0428 Streptococcus pneumoniae 70585 IS66 family element YP_002739728.1 380704 D 488221 CDS YP_002739729.1 225858219 7683571 380870..381220 1 NC_012468.1 identified by match to protein family HMM PF05717; IS66 family element 381220 7683571 SP70585_0429 Streptococcus pneumoniae 70585 IS66 family element YP_002739729.1 380870 D 488221 CDS YP_002739730.1 225858220 7684999 381285..381479 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 381479 7684999 SP70585_0430 Streptococcus pneumoniae 70585 hypothetical protein YP_002739730.1 381285 D 488221 CDS YP_002739731.1 225858221 7684387 complement(384486..384599) 1 NC_012468.1 hypothetical protein 384599 7684387 SP70585_0437 Streptococcus pneumoniae 70585 hypothetical protein YP_002739731.1 384486 R 488221 CDS YP_002739732.1 225858222 7682877 384649..386631 1 NC_012468.1 identified by match to protein family HMM PF00496; oligopeptide binding protein 386631 7682877 SP70585_0438 Streptococcus pneumoniae 70585 oligopeptide binding protein YP_002739732.1 384649 D 488221 CDS YP_002739733.1 225858223 7684816 386932..392235 1 NC_012468.1 identified by match to protein family HMM PF00754; match to protein family HMM PF04650; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; endo-alpha-N-acetylgalactosaminidase 392235 7684816 SP70585_0439 Streptococcus pneumoniae 70585 endo-alpha-N-acetylgalactosaminidase YP_002739733.1 386932 D 488221 CDS YP_002739734.1 225858224 7684125 complement(392402..394561) 1 NC_012468.1 identified by match to protein family HMM PF00905; match to protein family HMM PF00912; match to protein family HMM TIGR02074; penicillin-binding protein 1A 394561 7684125 SP70585_0440 Streptococcus pneumoniae 70585 penicillin-binding protein 1A YP_002739734.1 392402 R 488221 CDS YP_002739735.1 225858225 7683941 complement(394558..395154) 1 NC_012468.1 functions in homologous recombination, DNA repair, and chromosome segregation; binds preferentially to three- and four-stranded DNA intermediates; introduces specific nick sites in four-stranded DNA substrates; functions similarly to Escherichia coli RuvC; Holliday junction-specific endonuclease 395154 recU 7683941 recU Streptococcus pneumoniae 70585 Holliday junction-specific endonuclease YP_002739735.1 394558 R 488221 CDS YP_002739736.1 225858226 7683541 395220..395747 1 NC_012468.1 identified by match to protein family HMM PF06908; hypothetical protein 395747 7683541 SP70585_0442 Streptococcus pneumoniae 70585 hypothetical protein YP_002739736.1 395220 D 488221 CDS YP_002739737.1 225858227 7684172 395817..396146 1 NC_012468.1 identified by match to protein family HMM PF05103; cell division initiation protein 396146 7684172 SP70585_0443 Streptococcus pneumoniae 70585 cell division initiation protein YP_002739737.1 395817 D 488221 CDS YP_002739738.1 225858228 7684297 396632..397789 1 NC_012468.1 identified by match to protein family HMM PF01170; methyltransferase 397789 7684297 SP70585_0444 Streptococcus pneumoniae 70585 methyltransferase YP_002739738.1 396632 D 488221 CDS YP_002739739.1 225858229 7683043 397801..399195 1 NC_012468.1 hypothetical protein 399195 7683043 SP70585_0445 Streptococcus pneumoniae 70585 hypothetical protein YP_002739739.1 397801 D 488221 CDS YP_002739740.1 225858230 7684599 399271..400695 1 NC_012468.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase 400695 gnd 7684599 gnd Streptococcus pneumoniae 70585 6-phosphogluconate dehydrogenase YP_002739740.1 399271 D 488221 CDS YP_002739741.1 225858231 7684843 400707..401396 1 NC_012468.1 identified by match to protein family HMM PF00072; match to protein family HMM PF00486; DNA-binding response regulator 401396 7684843 SP70585_0447 Streptococcus pneumoniae 70585 DNA-binding response regulator YP_002739741.1 400707 D 488221 CDS YP_002739742.1 225858232 7684859 401494..402513 1 NC_012468.1 identified by match to protein family HMM PF01473; choline-binding protein F 402513 7684859 SP70585_0448 Streptococcus pneumoniae 70585 choline-binding protein F YP_002739742.1 401494 D 488221 CDS YP_002739743.1 225858233 7684932 complement(402631..403863) 1 NC_012468.1 transporter major facilitator family protein 403863 7684932 SP70585_0449 Streptococcus pneumoniae 70585 transporter major facilitator family protein YP_002739743.1 402631 R 488221 CDS YP_002739744.1 225858234 7684902 complement(404392..404730) 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 404730 7684902 SP70585_0450 Streptococcus pneumoniae 70585 hypothetical protein YP_002739744.1 404392 R 488221 CDS YP_002739745.1 225858235 7684721 405600..405722 1 NC_012468.1 identified by match to protein family HMM PF01473; choline-binding protein F 405722 7684721 SP70585_0451 Streptococcus pneumoniae 70585 choline-binding protein F YP_002739745.1 405600 D 488221 CDS YP_002739746.1 225858236 7683488 405844..406722 1 NC_012468.1 identified by match to protein family HMM PF00288; match to protein family HMM PF08544; match to protein family HMM TIGR00549; mevalonate kinase 406722 mvk 7683488 mvk Streptococcus pneumoniae 70585 mevalonate kinase YP_002739746.1 405844 D 488221 CDS YP_002739747.1 225858237 7684554 406704..407657 1 NC_012468.1 identified by match to protein family HMM PF00288; match to protein family HMM PF08544; match to protein family HMM TIGR01240; diphosphomevalonate decarboxylase 407657 mvaD 7684554 mvaD Streptococcus pneumoniae 70585 diphosphomevalonate decarboxylase YP_002739747.1 406704 D 488221 CDS YP_002739748.1 225858238 7684263 407644..408651 1 NC_012468.1 identified by match to protein family HMM PF00288; match to protein family HMM PF08544; match to protein family HMM TIGR01220; phosphomevalonate kinase 408651 7684263 SP70585_0454 Streptococcus pneumoniae 70585 phosphomevalonate kinase YP_002739748.1 407644 D 488221 CDS YP_002739749.1 225858239 7684998 408635..409645 1 NC_012468.1 catalyzes the isomerization of isopentenyl pyrophosphate to dimethylallyl diphosphate; isopentenyl pyrophosphate isomerase 409645 fni 7684998 fni Streptococcus pneumoniae 70585 isopentenyl pyrophosphate isomerase YP_002739749.1 408635 D 488221 CDS YP_002739750.1 225858240 7682987 409723..410421 1 NC_012468.1 hypothetical protein 410421 7682987 SP70585_0456 Streptococcus pneumoniae 70585 hypothetical protein YP_002739750.1 409723 D 488221 CDS YP_002739751.1 225858241 7683669 410418..411413 1 NC_012468.1 identified by match to protein family HMM PF02518; match to protein family HMM PF07730; histidine kinase 411413 7683669 SP70585_0457 Streptococcus pneumoniae 70585 histidine kinase YP_002739751.1 410418 D 488221 CDS YP_002739752.1 225858242 7683680 411427..412059 1 NC_012468.1 identified by match to protein family HMM PF00072; match to protein family HMM PF00196; match to protein family HMM PF08281; response regulator 412059 7683680 SP70585_0458 Streptococcus pneumoniae 70585 response regulator YP_002739752.1 411427 D 488221 CDS YP_002739753.1 225858243 7685175 412273..412527 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 412527 7685175 SP70585_0459 Streptococcus pneumoniae 70585 hypothetical protein YP_002739753.1 412273 D 488221 CDS YP_002739754.1 225858244 7684033 412642..412818 1 NC_012468.1 DNA alkylation repair enzyme 412818 7684033 SP70585_0460 Streptococcus pneumoniae 70585 DNA alkylation repair enzyme YP_002739754.1 412642 D 488221 CDS YP_002739755.1 225858245 7683814 412968..413207 1 NC_012468.1 hypothetical protein 413207 7683814 SP70585_0461 Streptococcus pneumoniae 70585 hypothetical protein YP_002739755.1 412968 D 488221 CDS YP_002739756.1 225858246 7683402 414132..415154 1 NC_012468.1 identified by match to protein family HMM PF01473; choline binding protein F 415154 7683402 SP70585_0464 Streptococcus pneumoniae 70585 choline binding protein F YP_002739756.1 414132 D 488221 CDS YP_002739757.1 225858247 7683711 complement(415282..415770) 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF00665; transposase, IS3 family 415770 7683711 SP70585_0465 Streptococcus pneumoniae 70585 transposase, IS3 family YP_002739757.1 415282 R 488221 CDS YP_002739758.1 225858248 7685005 complement(415823..416575) 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase 416575 7685005 SP70585_0466 Streptococcus pneumoniae 70585 transposase YP_002739758.1 415823 R 488221 CDS YP_002739759.1 225858249 7684098 416727..418496 1 NC_012468.1 identified by match to protein family HMM PF02302; match to protein family HMM PF02378; match to protein family HMM TIGR00851; pts system mannitol-specific eiicb component (eiicb-mtl) (eii-mtl) 418496 7684098 SP70585_0467 Streptococcus pneumoniae 70585 pts system mannitol-specific eiicb component (eiicb-mtl) (eii-mtl) YP_002739759.1 416727 D 488221 CDS YP_002739760.1 225858250 7683634 418520..420475 1 NC_012468.1 identified by match to protein family HMM PF08279; putative transcriptional regulator MtlR 420475 7683634 SP70585_0468 Streptococcus pneumoniae 70585 putative transcriptional regulator MtlR YP_002739760.1 418520 D 488221 CDS YP_002739761.1 225858251 7684015 420477..420914 1 NC_012468.1 identified by match to protein family HMM PF00359; mannitol-specific phosphotransferase enzyme iia component (pts system mannitol-specific eiia component) (eiia-mtl) (eiii-mtl) 420914 7684015 SP70585_0469 Streptococcus pneumoniae 70585 mannitol-specific phosphotransferase enzyme iia component (pts system mannitol-specific eiia component) (eiia-mtl) (eiii-mtl) YP_002739761.1 420477 D 488221 CDS YP_002739762.1 225858252 7684183 420976..422112 1 NC_012468.1 identified by match to protein family HMM PF01232; match to protein family HMM PF08125; mannitol-1-phosphate 5-dehydrogenase 422112 7684183 SP70585_0470 Streptococcus pneumoniae 70585 mannitol-1-phosphate 5-dehydrogenase YP_002739762.1 420976 D 488221 CDS YP_002739763.1 225858253 7683953 422494..422607 1 NC_012468.1 hypothetical protein 422607 7683953 SP70585_0471 Streptococcus pneumoniae 70585 hypothetical protein YP_002739763.1 422494 D 488221 CDS YP_002739764.1 225858254 7684509 422920..424203 1 NC_012468.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 424203 tig 7684509 tig Streptococcus pneumoniae 70585 trigger factor YP_002739764.1 422920 D 488221 CDS YP_002739765.1 225858255 7684890 complement(424251..426617) 1 NC_012468.1 identified by match to protein family HMM TIGR01448; helicase, RecD/TraA family 426617 7684890 SP70585_0473 Streptococcus pneumoniae 70585 helicase, RecD/TraA family YP_002739765.1 424251 R 488221 CDS YP_002739766.1 225858256 7682911 complement(426745..427359) 1 NC_012468.1 identified by match to protein family HMM PF00717; match to protein family HMM TIGR02227; signal peptidase I 427359 lepB 7682911 lepB Streptococcus pneumoniae 70585 signal peptidase I YP_002739766.1 426745 R 488221 CDS YP_002739767.1 225858257 7683552 complement(427363..428244) 1 NC_012468.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease HIII 428244 rnhC 7683552 rnhC Streptococcus pneumoniae 70585 ribonuclease HIII YP_002739767.1 427363 R 488221 CDS YP_002739768.1 225858258 7683101 428409..428633 1 NC_012468.1 hypothetical protein 428633 7683101 SP70585_0476 Streptococcus pneumoniae 70585 hypothetical protein YP_002739768.1 428409 D 488221 CDS YP_002739769.1 225858259 7684410 428630..429178 1 NC_012468.1 identified by match to protein family HMM PF02674; CvpA family protein 429178 cvpA 7684410 cvpA Streptococcus pneumoniae 70585 CvpA family protein YP_002739769.1 428630 D 488221 CDS YP_002739770.1 225858260 7683469 429282..431618 1 NC_012468.1 identified by match to protein family HMM PF00488; match to protein family HMM PF01713; match to protein family HMM TIGR01069; MutS2 family protein 431618 7683469 SP70585_0478 Streptococcus pneumoniae 70585 MutS2 family protein YP_002739770.1 429282 D 488221 CDS YP_002739771.1 225858261 7684087 431961..433283 1 NC_012468.1 identified by match to protein family HMM PF01235; match to protein family HMM TIGR00835; D-alanine glycine permease 433283 7684087 SP70585_0479 Streptococcus pneumoniae 70585 D-alanine glycine permease YP_002739771.1 431961 D 488221 CDS YP_002739772.1 225858262 7683602 433501..434049 1 NC_012468.1 identified by match to protein family HMM PF02627; match to protein family HMM TIGR00778; macrophage infectivity potentiator protein 434049 7683602 SP70585_0480 Streptococcus pneumoniae 70585 macrophage infectivity potentiator protein YP_002739772.1 433501 D 488221 CDS YP_002739773.1 225858263 7684109 434158..435057 1 NC_012468.1 identified by match to protein family HMM PF03595; exfoliative toxin A 435057 7684109 SP70585_0481 Streptococcus pneumoniae 70585 exfoliative toxin A YP_002739773.1 434158 D 488221 CDS YP_002739774.1 225858264 7684046 complement(435082..436356) 1 NC_012468.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 436356 serS 7684046 serS Streptococcus pneumoniae 70585 seryl-tRNA synthetase YP_002739774.1 435082 R 488221 CDS YP_002739775.1 225858265 7683800 complement(436570..436941) 1 NC_012468.1 identified by match to protein family HMM PF06115; ManO 436941 7683800 SP70585_0483 Streptococcus pneumoniae 70585 ManO YP_002739775.1 436570 R 488221 CDS YP_002739776.1 225858266 7683799 complement(436944..438308) 1 NC_012468.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; lysine and threonine sensitive; aspartate kinase 438308 7683799 SP70585_0484 Streptococcus pneumoniae 70585 aspartate kinase YP_002739776.1 436944 R 488221 CDS YP_002739777.1 225858267 7684396 complement(438392..438685) 1 NC_012468.1 hypothetical protein 438685 7684396 SP70585_0485 Streptococcus pneumoniae 70585 hypothetical protein YP_002739777.1 438392 R 488221 CDS YP_002739778.1 225858268 7684247 438677..439462 1 NC_012468.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 439462 7684247 SP70585_0486 Streptococcus pneumoniae 70585 enoyl-CoA hydratase YP_002739778.1 438677 D 488221 CDS YP_002739779.1 225858269 7684962 439556..439990 1 NC_012468.1 identified by match to protein family HMM PF01047; match to protein family HMM PF03965; transcriptional regulator 439990 7684962 SP70585_0487 Streptococcus pneumoniae 70585 transcriptional regulator YP_002739779.1 439556 D 488221 CDS YP_002739780.1 225858270 7683228 439990..440964 1 NC_012468.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-(acyl carrier protein) synthase III 440964 7683228 SP70585_0488 Streptococcus pneumoniae 70585 3-oxoacyl-(acyl carrier protein) synthase III YP_002739780.1 439990 D 488221 CDS YP_002739781.1 225858271 7683708 441024..441248 1 NC_012468.1 carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 441248 acpP 7683708 acpP Streptococcus pneumoniae 70585 acyl carrier protein YP_002739781.1 441024 D 488221 CDS YP_002739782.1 225858272 7684746 441367..442341 1 NC_012468.1 identified by match to protein family HMM PF03060; match to protein family HMM TIGR03151; enoyl-ACP reductase II 442341 7684746 SP70585_0490 Streptococcus pneumoniae 70585 enoyl-ACP reductase II YP_002739782.1 441367 D 488221 CDS YP_002739783.1 225858273 7683308 442334..443254 1 NC_012468.1 identified by match to protein family HMM PF00698; match to protein family HMM TIGR00128; malonyl CoA-acyl carrier protein transacylase 443254 fabD 7683308 fabD Streptococcus pneumoniae 70585 malonyl CoA-acyl carrier protein transacylase YP_002739783.1 442334 D 488221 CDS YP_002739784.1 225858274 7684602 443288..444019 1 NC_012468.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 444019 fabG 7684602 fabG Streptococcus pneumoniae 70585 3-ketoacyl-ACP reductase YP_002739784.1 443288 D 488221 CDS YP_002739785.1 225858275 7684981 444041..445276 1 NC_012468.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-(acyl carrier protein) synthase II 445276 fabF 7684981 fabF Streptococcus pneumoniae 70585 3-oxoacyl-(acyl carrier protein) synthase II YP_002739785.1 444041 D 488221 CDS YP_002739786.1 225858276 7685178 445279..445764 1 NC_012468.1 composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 445764 accB 7685178 accB Streptococcus pneumoniae 70585 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit YP_002739786.1 445279 D 488221 CDS YP_002739787.1 225858277 7683136 445761..446183 1 NC_012468.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 446183 fabZ 7683136 fabZ Streptococcus pneumoniae 70585 (3R)-hydroxymyristoyl-ACP dehydratase YP_002739787.1 445761 D 488221 CDS YP_002739788.1 225858278 7682993 446195..447562 1 NC_012468.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxylase subunit 447562 accC 7682993 accC Streptococcus pneumoniae 70585 acetyl-CoA carboxylase biotin carboxylase subunit YP_002739788.1 446195 D 488221 CDS YP_002739789.1 225858279 7684703 447599..448465 1 NC_012468.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta 448465 accD 7684703 accD Streptococcus pneumoniae 70585 acetyl-CoA carboxylase subunit beta YP_002739789.1 447599 D 488221 CDS YP_002739790.1 225858280 7684449 448462..449229 1 NC_012468.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; these proteins present a shorter N-terminus; acetyl-CoA carboxylase subunit alpha 449229 accA 7684449 accA Streptococcus pneumoniae 70585 acetyl-CoA carboxylase subunit alpha YP_002739790.1 448462 D 488221 CDS YP_002739791.1 225858281 7684223 449388..449573 1 NC_012468.1 hypothetical protein 449573 7684223 SP70585_0499 Streptococcus pneumoniae 70585 hypothetical protein YP_002739791.1 449388 D 488221 CDS YP_002739792.1 225858282 7683609 449732..449881 1 NC_012468.1 hypothetical protein 449881 7683609 SP70585_0500 Streptococcus pneumoniae 70585 hypothetical protein YP_002739792.1 449732 D 488221 CDS YP_002739793.1 225858283 7684092 449936..450313 1 NC_012468.1 identified by match to protein family HMM PF02517; abortive infection protein 450313 7684092 SP70585_0501 Streptococcus pneumoniae 70585 abortive infection protein YP_002739793.1 449936 D 488221 CDS YP_002739794.1 225858284 7685031 complement(450362..450784) 1 NC_012468.1 Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 450784 nusB 7685031 nusB Streptococcus pneumoniae 70585 transcription antitermination protein NusB YP_002739794.1 450362 R 488221 CDS YP_002739795.1 225858285 7683824 complement(450777..451166) 1 NC_012468.1 identified by match to protein family HMM PF03780; general stress protein, Gls24 family 451166 7683824 SP70585_0503 Streptococcus pneumoniae 70585 general stress protein, Gls24 family YP_002739795.1 450777 R 488221 CDS YP_002739796.1 225858286 7684983 complement(451188..451748) 1 NC_012468.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 451748 efp 7684983 efp Streptococcus pneumoniae 70585 elongation factor P YP_002739796.1 451188 R 488221 CDS YP_002739797.1 225858287 7683779 complement(451877..453319) 1 NC_012468.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit B 453319 gatB 7683779 gatB Streptococcus pneumoniae 70585 aspartyl/glutamyl-tRNA amidotransferase subunit B YP_002739797.1 451877 R 488221 CDS YP_002739798.1 225858288 7683664 complement(453319..454785) 1 NC_012468.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A 454785 gatA 7683664 gatA Streptococcus pneumoniae 70585 aspartyl/glutamyl-tRNA amidotransferase subunit A YP_002739798.1 453319 R 488221 CDS YP_002739799.1 225858289 7683713 complement(454785..455087) 1 NC_012468.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain; aspartyl/glutamyl-tRNA amidotransferase subunit C 455087 gatC 7683713 gatC Streptococcus pneumoniae 70585 aspartyl/glutamyl-tRNA amidotransferase subunit C YP_002739799.1 454785 R 488221 CDS YP_002739800.1 225858290 7683210 455300..456844 1 NC_012468.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 456844 prfC 7683210 prfC Streptococcus pneumoniae 70585 peptide chain release factor 3 YP_002739800.1 455300 D 488221 CDS YP_002739801.1 225858291 7684244 457872..458060 1 NC_012468.1 required for 70S ribosome assembly; 50S ribosomal protein L28 458060 rpmB 7684244 rpmB Streptococcus pneumoniae 70585 50S ribosomal protein L28 YP_002739801.1 457872 D 488221 CDS YP_002739802.1 225858292 7683704 458217..458582 1 NC_012468.1 identified by match to protein family HMM PF03780; alkaline shock protein 458582 7683704 SP70585_0512 Streptococcus pneumoniae 70585 alkaline shock protein YP_002739802.1 458217 D 488221 CDS YP_002739803.1 225858293 7683115 458585..460252 1 NC_012468.1 identified by match to protein family HMM PF02734; dihydroxyacetone kinase family protein 460252 7683115 SP70585_0513 Streptococcus pneumoniae 70585 dihydroxyacetone kinase family protein YP_002739803.1 458585 D 488221 CDS YP_002739804.1 225858294 7684675 460453..462153 1 NC_012468.1 catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; acetolactate synthase catalytic subunit 462153 ilvB 7684675 ilvB Streptococcus pneumoniae 70585 acetolactate synthase catalytic subunit YP_002739804.1 460453 D 488221 CDS YP_002739805.1 225858295 7682912 462146..462622 1 NC_012468.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 462622 ilvH 7682912 ilvH Streptococcus pneumoniae 70585 acetolactate synthase 3 regulatory subunit YP_002739805.1 462146 D 488221 CDS YP_002739806.1 225858296 7683254 462688..463710 1 NC_012468.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 463710 ilvC 7683254 ilvC Streptococcus pneumoniae 70585 ketol-acid reductoisomerase YP_002739806.1 462688 D 488221 CDS YP_002739807.1 225858297 7683485 463817..464053 1 NC_012468.1 hypothetical protein 464053 7683485 SP70585_0517 Streptococcus pneumoniae 70585 hypothetical protein YP_002739807.1 463817 D 488221 CDS YP_002739808.1 225858298 7683649 464291..464647 1 NC_012468.1 hypothetical protein 464647 7683649 SP70585_0518 Streptococcus pneumoniae 70585 hypothetical protein YP_002739808.1 464291 D 488221 CDS YP_002739809.1 225858299 7684532 464697..465947 1 NC_012468.1 catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic; threonine dehydratase 465947 ilvA 7684532 ilvA Streptococcus pneumoniae 70585 threonine dehydratase YP_002739809.1 464697 D 488221 CDS YP_002739810.1 225858300 7683355 466089..466277 1 NC_012468.1 hypothetical protein 466277 7683355 SP70585_0520 Streptococcus pneumoniae 70585 hypothetical protein YP_002739810.1 466089 D 488221 CDS YP_002739811.1 225858301 7683563 466817..467032 1 NC_012468.1 hypothetical protein 467032 7683563 SP70585_0521 Streptococcus pneumoniae 70585 hypothetical protein YP_002739811.1 466817 D 488221 CDS YP_002739812.1 225858302 7684720 complement(467141..467881) 1 NC_012468.1 identified by match to protein family HMM PF00005; L-cystine import ATP-binding protein TcyN 467881 7684720 SP70585_0522 Streptococcus pneumoniae 70585 L-cystine import ATP-binding protein TcyN YP_002739812.1 467141 R 488221 CDS YP_002739813.1 225858303 7684928 complement(467881..469446) 1 NC_012468.1 identified by match to protein family HMM PF00497; match to protein family HMM PF00528; match to protein family HMM TIGR01726; amino acid ABC transporter permease/substrate-binding protein 469446 7684928 SP70585_0523 Streptococcus pneumoniae 70585 amino acid ABC transporter permease/substrate-binding protein YP_002739813.1 467881 R 488221 CDS YP_002739814.1 225858304 7683133 469584..471473 1 NC_012468.1 hypothetical protein 471473 7683133 SP70585_0525 Streptococcus pneumoniae 70585 hypothetical protein YP_002739814.1 469584 D 488221 CDS YP_002739815.1 225858305 7685133 complement(471470..471640) 1 NC_012468.1 hypothetical protein 471640 7685133 SP70585_0524 Streptococcus pneumoniae 70585 hypothetical protein YP_002739815.1 471470 R 488221 CDS YP_002739816.1 225858306 7684818 complement(471774..472322) 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF02371; transposase 472322 7684818 SP70585_0526 Streptococcus pneumoniae 70585 transposase YP_002739816.1 471774 R 488221 CDS YP_002739817.1 225858307 7684403 complement(472520..472642) 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase 472642 7684403 SP70585_0527 Streptococcus pneumoniae 70585 transposase YP_002739817.1 472520 R 488221 CDS YP_002739818.1 225858308 7684586 472898..473743 1 NC_012468.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; UDP pyrophosphate phosphatase 473743 7684586 SP70585_0528 Streptococcus pneumoniae 70585 UDP pyrophosphate phosphatase YP_002739818.1 472898 D 488221 CDS YP_002739819.1 225858309 7684839 473736..473864 1 NC_012468.1 hypothetical protein 473864 7684839 SP70585_0529 Streptococcus pneumoniae 70585 hypothetical protein YP_002739819.1 473736 D 488221 CDS YP_002739820.1 225858310 7683431 complement(473890..474951) 1 NC_012468.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 474951 dinB 7683431 dinB Streptococcus pneumoniae 70585 DNA polymerase IV YP_002739820.1 473890 R 488221 CDS YP_002739821.1 225858311 7683761 complement(474996..475118) 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 475118 7683761 SP70585_0531 Streptococcus pneumoniae 70585 hypothetical protein YP_002739821.1 474996 R 488221 CDS YP_002739822.1 225858312 7684989 475345..477669 1 NC_012468.1 identified by match to protein family HMM PF01228; match to protein family HMM PF02901; match to protein family HMM TIGR01255; formate acetyltransferase 477669 pflB 7684989 pflB Streptococcus pneumoniae 70585 formate acetyltransferase YP_002739822.1 475345 D 488221 CDS YP_002739823.1 225858313 7683727 complement(478036..478593) 1 NC_012468.1 hypothetical protein 478593 7683727 SP70585_0533 Streptococcus pneumoniae 70585 hypothetical protein YP_002739823.1 478036 R 488221 CDS YP_002739824.1 225858314 7685017 complement(478586..478870) 1 NC_012468.1 hypothetical protein 478870 7685017 SP70585_0534 Streptococcus pneumoniae 70585 hypothetical protein YP_002739824.1 478586 R 488221 CDS YP_002739825.1 225858315 7684229 complement(479483..479653) 1 NC_012468.1 hypothetical protein 479653 7684229 SP70585_0535 Streptococcus pneumoniae 70585 hypothetical protein YP_002739825.1 479483 R 488221 CDS YP_002739826.1 225858316 7685065 complement(480313..481536) 1 NC_012468.1 identified by match to protein family HMM PF00480; xylose repressor protein 481536 7685065 SP70585_0536 Streptococcus pneumoniae 70585 xylose repressor protein YP_002739826.1 480313 R 488221 CDS YP_002739827.1 225858317 7684524 481704..483026 1 NC_012468.1 identified by match to protein family HMM PF02378; match to protein family HMM TIGR00410; lichenan permease iic component (pts system lichenan-specific eiiccomponent) (eiic-lic) 483026 7684524 SP70585_0537 Streptococcus pneumoniae 70585 lichenan permease iic component (pts system lichenan-specific eiiccomponent) (eiic-lic) YP_002739827.1 481704 D 488221 CDS YP_002739828.1 225858318 7683765 483028..484914 1 NC_012468.1 hypothetical protein 484914 7683765 SP70585_0538 Streptococcus pneumoniae 70585 hypothetical protein YP_002739828.1 483028 D 488221 CDS YP_002739829.1 225858319 7684706 485082..485426 1 NC_012468.1 identified by match to protein family HMM PF02255; lactose-specific phosphotransferase enzyme iia component (pts system lactose-specific eiia component) (eiia-lac) (eiii-lac) 485426 7684706 SP70585_0539 Streptococcus pneumoniae 70585 lactose-specific phosphotransferase enzyme iia component (pts system lactose-specific eiia component) (eiia-lac) (eiii-lac) YP_002739829.1 485082 D 488221 CDS YP_002739830.1 225858320 7684029 485436..486848 1 NC_012468.1 catalyzes the formation of 6-phospho-galactose from a 6-phospho-beta-galactoside; 6-phospho-beta-galactosidase 486848 lacG1 7684029 lacG1 Streptococcus pneumoniae 70585 6-phospho-beta-galactosidase YP_002739830.1 485436 D 488221 CDS YP_002739831.1 225858321 7683808 486918..488597 1 NC_012468.1 identified by match to protein family HMM PF02302; match to protein family HMM PF02378; pts system lactose-specific eiicb component (eiicb-lac) (eii-lac) 488597 7683808 SP70585_0541 Streptococcus pneumoniae 70585 pts system lactose-specific eiicb component (eiicb-lac) (eii-lac) YP_002739831.1 486918 D 488221 CDS YP_002739832.1 225858322 7683238 complement(488723..490162) 1 NC_012468.1 identified by match to protein family HMM PF02386; Trk transporter membrane-spanning protein - K+ transport 490162 7683238 SP70585_0542 Streptococcus pneumoniae 70585 Trk transporter membrane-spanning protein - K+ transport YP_002739832.1 488723 R 488221 CDS YP_002739833.1 225858323 7684695 complement(490166..491515) 1 NC_012468.1 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane component 491515 trkA 7684695 trkA Streptococcus pneumoniae 70585 potassium transporter peripheral membrane component YP_002739833.1 490166 R 488221 CDS YP_002739834.1 225858324 7684145 491704..492552 1 NC_012468.1 identified by match to protein family HMM PF01887; hypothetical protein 492552 7684145 SP70585_0544 Streptococcus pneumoniae 70585 hypothetical protein YP_002739834.1 491704 D 488221 CDS YP_002739835.1 225858325 7684076 492567..493115 1 NC_012468.1 identified by match to protein family HMM PF07155; hypothetical protein 493115 7684076 SP70585_0545 Streptococcus pneumoniae 70585 hypothetical protein YP_002739835.1 492567 D 488221 CDS YP_002739836.1 225858326 7684176 493122..493424 1 NC_012468.1 chlorohydrolase 493424 7684176 SP70585_0546 Streptococcus pneumoniae 70585 chlorohydrolase YP_002739836.1 493122 D 488221 CDS YP_002739837.1 225858327 7683561 493526..495208 1 NC_012468.1 identified by match to protein family HMM PF00005; putative ABC transporter ATP-binding protein 495208 7683561 SP70585_0547 Streptococcus pneumoniae 70585 putative ABC transporter ATP-binding protein YP_002739837.1 493526 D 488221 CDS YP_002739838.1 225858328 7684460 495193..496023 1 NC_012468.1 identified by match to protein family HMM PF02361; cobalt transport family protein 496023 7684460 SP70585_0548 Streptococcus pneumoniae 70585 cobalt transport family protein YP_002739838.1 495193 D 488221 CDS YP_002739839.1 225858329 7684992 496216..496719 1 NC_012468.1 identified by match to protein family HMM PF00588; CspR 496719 cspR 7684992 cspR Streptococcus pneumoniae 70585 CspR YP_002739839.1 496216 D 488221 CDS YP_002739840.1 225858330 7683176 497172..497735 1 NC_012468.1 hypothetical protein 497735 7683176 SP70585_0550 Streptococcus pneumoniae 70585 hypothetical protein YP_002739840.1 497172 D 488221 CDS YP_002739841.1 225858331 7683319 497749..498375 1 NC_012468.1 identified by match to protein family HMM PF01569; PAP2 family protein 498375 7683319 SP70585_0551 Streptococcus pneumoniae 70585 PAP2 family protein YP_002739841.1 497749 D 488221 CDS YP_002739842.1 225858332 7684764 498402..498791 1 NC_012468.1 hypothetical protein 498791 7684764 SP70585_0552 Streptococcus pneumoniae 70585 hypothetical protein YP_002739842.1 498402 D 488221 CDS YP_002739843.1 225858333 7683567 498796..499245 1 NC_012468.1 hypothetical protein 499245 7683567 SP70585_0553 Streptococcus pneumoniae 70585 hypothetical protein YP_002739843.1 498796 D 488221 CDS YP_002739844.1 225858334 7683165 499373..499960 1 NC_012468.1 participates in both the initiation and recycling phases of transcription; in the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling; DNA-directed RNA polymerase subunit delta 499960 rpoE 7683165 rpoE Streptococcus pneumoniae 70585 DNA-directed RNA polymerase subunit delta YP_002739844.1 499373 D 488221 CDS YP_002739845.1 225858335 7684778 complement(500050..500187) 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 500187 7684778 SP70585_0555 Streptococcus pneumoniae 70585 hypothetical protein YP_002739845.1 500050 R 488221 CDS YP_002739846.1 225858336 7684607 500350..501957 1 NC_012468.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 501957 pyrG 7684607 pyrG Streptococcus pneumoniae 70585 CTP synthetase YP_002739846.1 500350 D 488221 CDS YP_002739847.1 225858337 7683398 complement(502516..504147) 1 NC_012468.1 identified by match to protein family HMM PF01895; match to protein family HMM PF02690; match to protein family HMM TIGR00704; sodium-dependent phosphate transporter 504147 7683398 SP70585_0557 Streptococcus pneumoniae 70585 sodium-dependent phosphate transporter YP_002739847.1 502516 R 488221 CDS YP_002739848.1 225858338 7685046 504512..509380 1 NC_012468.1 identified by match to protein family HMM PF00746; match to protein family HMM PF00754; match to protein family HMM PF03644; match to protein family HMM PF07501; match to protein family HMM PF07523; match to protein family HMM TIGR01167; endo-beta-N-acetylglucosaminidase D 509380 7685046 SP70585_0558 Streptococcus pneumoniae 70585 endo-beta-N-acetylglucosaminidase D YP_002739848.1 504512 D 488221 CDS YP_002739849.1 225858339 7683794 509470..510666 1 NC_012468.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 510666 pgk 7683794 pgk Streptococcus pneumoniae 70585 phosphoglycerate kinase YP_002739849.1 509470 D 488221 CDS YP_002739850.1 225858340 7683786 510802..511329 1 NC_012468.1 hypothetical protein 511329 7683786 SP70585_0560 Streptococcus pneumoniae 70585 hypothetical protein YP_002739850.1 510802 D 488221 CDS YP_002739851.1 225858341 7683460 511406..511762 1 NC_012468.1 identified by match to protein family HMM PF00376; HTH-type transcriptional regulator GlnR 511762 7683460 SP70585_0561 Streptococcus pneumoniae 70585 HTH-type transcriptional regulator GlnR YP_002739851.1 511406 D 488221 CDS YP_002739852.1 225858342 7684741 511799..513145 1 NC_012468.1 identified by match to protein family HMM PF00120; match to protein family HMM PF03951; match to protein family HMM TIGR00653; glutamine synthetase, type I 513145 glnA 7684741 glnA Streptococcus pneumoniae 70585 glutamine synthetase, type I YP_002739852.1 511799 D 488221 CDS YP_002739853.1 225858343 7684344 complement(513235..513354) 1 NC_012468.1 hypothetical protein 513354 7684344 SP70585_0563 Streptococcus pneumoniae 70585 hypothetical protein YP_002739853.1 513235 R 488221 CDS YP_002739854.1 225858344 7682946 513319..513468 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 513468 7682946 SP70585_0564 Streptococcus pneumoniae 70585 hypothetical protein YP_002739854.1 513319 D 488221 CDS YP_002739855.1 225858345 7683970 513612..513749 1 NC_012468.1 hypothetical protein 513749 7683970 SP70585_0565 Streptococcus pneumoniae 70585 hypothetical protein YP_002739855.1 513612 D 488221 CDS YP_002739856.1 225858346 7684947 complement(515163..516713) 1 NC_012468.1 identified by match to protein family HMM PF01420; type I restriction enzyme 516713 7684947 SP70585_0566 Streptococcus pneumoniae 70585 type I restriction enzyme YP_002739856.1 515163 R 488221 CDS YP_002739857.1 225858347 7682889 complement(516713..518176) 1 NC_012468.1 identified by match to protein family HMM PF02384; type I restriction enzyme 518176 7682889 SP70585_0567 Streptococcus pneumoniae 70585 type I restriction enzyme YP_002739857.1 516713 R 488221 CDS YP_002739858.1 225858348 7684648 complement(518189..520522) 1 NC_012468.1 identified by match to protein family HMM PF00270; match to protein family HMM PF04313; match to protein family HMM PF04851; match to protein family HMM PF08463; type I restriction-modification system, R subunit 520522 7684648 SP70585_0568 Streptococcus pneumoniae 70585 type I restriction-modification system, R subunit YP_002739858.1 518189 R 488221 CDS YP_002739859.1 225858349 7683828 520900..521094 1 NC_012468.1 hypothetical protein 521094 7683828 SP70585_0569 Streptococcus pneumoniae 70585 hypothetical protein YP_002739859.1 520900 D 488221 CDS YP_002739860.1 225858350 7685131 521129..521638 1 NC_012468.1 hypothetical protein 521638 7685131 SP70585_0570 Streptococcus pneumoniae 70585 hypothetical protein YP_002739860.1 521129 D 488221 CDS YP_002739861.1 225858351 7683368 521802..522836 1 NC_012468.1 Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons; heat-inducible transcription repressor 522836 hrcA 7683368 hrcA Streptococcus pneumoniae 70585 heat-inducible transcription repressor YP_002739861.1 521802 D 488221 CDS YP_002739862.1 225858352 7683855 522863..523387 1 NC_012468.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 523387 grpE 7683855 grpE Streptococcus pneumoniae 70585 heat shock protein GrpE YP_002739862.1 522863 D 488221 CDS YP_002739863.1 225858353 7683599 523856..525679 1 NC_012468.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 525679 dnaK 7683599 dnaK Streptococcus pneumoniae 70585 molecular chaperone DnaK YP_002739863.1 523856 D 488221 CDS YP_002739864.1 225858354 7683197 525690..526094 1 NC_012468.1 hypothetical protein 526094 7683197 SP70585_0574 Streptococcus pneumoniae 70585 hypothetical protein YP_002739864.1 525690 D 488221 CDS YP_002739865.1 225858355 7683188 526438..527574 1 NC_012468.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ 527574 dnaJ 7683188 dnaJ Streptococcus pneumoniae 70585 chaperone protein DnaJ YP_002739865.1 526438 D 488221 CDS YP_002739866.1 225858356 7684980 complement(527881..528120) 1 NC_012468.1 chlorohydrolase 528120 7684980 SP70585_0576 Streptococcus pneumoniae 70585 chlorohydrolase YP_002739866.1 527881 R 488221 CDS YP_002739867.1 225858357 7684007 complement(528282..528569) 1 NC_012468.1 hypothetical protein 528569 7684007 SP70585_0577 Streptococcus pneumoniae 70585 hypothetical protein YP_002739867.1 528282 R 488221 CDS YP_002739868.1 225858358 7683374 complement(528579..528989) 1 NC_012468.1 identified by match to protein family HMM PF01230; histidine triad domain protein 528989 7683374 SP70585_0578 Streptococcus pneumoniae 70585 histidine triad domain protein YP_002739868.1 528579 R 488221 CDS YP_002739869.1 225858359 7684424 529057..529788 1 NC_012468.1 identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 529788 7684424 SP70585_0579 Streptococcus pneumoniae 70585 ABC transporter ATP-binding protein YP_002739869.1 529057 D 488221 CDS YP_002739870.1 225858360 7683944 529785..530834 1 NC_012468.1 identified by match to protein family HMM PF05975; ABC transporter permease 530834 7683944 SP70585_0580 Streptococcus pneumoniae 70585 ABC transporter permease YP_002739870.1 529785 D 488221 CDS YP_002739871.1 225858361 7683858 complement(531002..531331) 1 NC_012468.1 BlpT protein, fusion 531331 7683858 SP70585_0581 Streptococcus pneumoniae 70585 BlpT protein, fusion YP_002739871.1 531002 R 488221 CDS YP_002739872.1 225858362 7684783 531607..531945 1 NC_012468.1 identified by match to protein family HMM PF04397; BlpS protein 531945 7684783 SP70585_0582 Streptococcus pneumoniae 70585 BlpS protein YP_002739872.1 531607 D 488221 CDS YP_002739873.1 225858363 7683720 531950..532687 1 NC_012468.1 identified by match to protein family HMM PF00072; match to protein family HMM PF04397; response regulator 532687 7683720 SP70585_0583 Streptococcus pneumoniae 70585 response regulator YP_002739873.1 531950 D 488221 CDS YP_002739874.1 225858364 7683435 532701..534041 1 NC_012468.1 identified by match to protein family HMM PF02518; histidine kinase 534041 7683435 SP70585_0584 Streptococcus pneumoniae 70585 histidine kinase YP_002739874.1 532701 D 488221 CDS YP_002739875.1 225858365 7683224 complement(534083..534238) 1 NC_012468.1 identified by match to protein family HMM PF08128; match to protein family HMM TIGR01847; double glycine cleavage site bacteriolysin superfamily 534238 7683224 SP70585_0585 Streptococcus pneumoniae 70585 double glycine cleavage site bacteriolysin superfamily YP_002739875.1 534083 R 488221 CDS YP_002739876.1 225858366 7684261 complement(534295..535656) 1 NC_012468.1 identified by match to protein family HMM TIGR01000; BlpC ABC transporter 535656 7684261 SP70585_0586 Streptococcus pneumoniae 70585 BlpC ABC transporter YP_002739876.1 534295 R 488221 CDS YP_002739877.1 225858367 7683592 538106..538303 1 NC_012468.1 hypothetical protein 538303 7683592 SP70585_0589 Streptococcus pneumoniae 70585 hypothetical protein YP_002739877.1 538106 D 488221 CDS YP_002739878.1 225858368 7684140 538770..539039 1 NC_012468.1 identified by match to protein family HMM TIGR01847; bacteriocin BlpJ 539039 7684140 SP70585_0590 Streptococcus pneumoniae 70585 bacteriocin BlpJ YP_002739878.1 538770 D 488221 CDS YP_002739879.1 225858369 7683694 539108..539338 1 NC_012468.1 identified by match to protein family HMM TIGR01847; hypothetical protein 539338 7683694 SP70585_0591 Streptococcus pneumoniae 70585 hypothetical protein YP_002739879.1 539108 D 488221 CDS YP_002739880.1 225858370 7683632 539341..539460 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 539460 7683632 SP70585_0592 Streptococcus pneumoniae 70585 hypothetical protein YP_002739880.1 539341 D 488221 CDS YP_002739881.1 225858371 7682901 539573..539689 1 NC_012468.1 hypothetical protein 539689 7682901 SP70585_0593 Streptococcus pneumoniae 70585 hypothetical protein YP_002739881.1 539573 D 488221 CDS YP_002739882.1 225858372 7683279 539757..539921 1 NC_012468.1 hypothetical protein 539921 7683279 SP70585_0594 Streptococcus pneumoniae 70585 hypothetical protein YP_002739882.1 539757 D 488221 CDS YP_002739883.1 225858373 7684431 539918..540322 1 NC_012468.1 immunity protein BlpL 540322 7684431 SP70585_0595 Streptococcus pneumoniae 70585 immunity protein BlpL YP_002739883.1 539918 D 488221 CDS YP_002739884.1 225858374 7685117 540387..540848 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase 540848 7685117 SP70585_0596 Streptococcus pneumoniae 70585 transposase YP_002739884.1 540387 D 488221 CDS YP_002739885.1 225858375 7684017 540860..541237 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01609; transposase (IS4 family) 541237 7684017 SP70585_0597 Streptococcus pneumoniae 70585 transposase (IS4 family) YP_002739885.1 540860 D 488221 CDS YP_002739886.1 225858376 7684214 541398..541721 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; mobile genetic element 541721 7684214 SP70585_0598 Streptococcus pneumoniae 70585 mobile genetic element YP_002739886.1 541398 D 488221 CDS YP_002739887.1 225858377 7684565 541815..542204 1 NC_012468.1 identified by match to protein family HMM PF01609; transposase (IS4 family) 542204 7684565 SP70585_0599 Streptococcus pneumoniae 70585 transposase (IS4 family) YP_002739887.1 541815 D 488221 CDS YP_002739888.1 225858378 7683682 542354..542608 1 NC_012468.1 identified by match to protein family HMM TIGR01847; bacteriocin BlpM 542608 7683682 SP70585_0600 Streptococcus pneumoniae 70585 bacteriocin BlpM YP_002739888.1 542354 D 488221 CDS YP_002739889.1 225858379 7683478 542624..542827 1 NC_012468.1 hypothetical protein 542827 7683478 SP70585_0601 Streptococcus pneumoniae 70585 hypothetical protein YP_002739889.1 542624 D 488221 CDS YP_002739890.1 225858380 7684529 543071..543220 1 NC_012468.1 identified by match to protein family HMM TIGR01847; BlpO protein 543220 7684529 SP70585_0602 Streptococcus pneumoniae 70585 BlpO protein YP_002739890.1 543071 D 488221 CDS YP_002739891.1 225858381 7684055 543202..543321 1 NC_012468.1 hypothetical protein 543321 7684055 SP70585_0603 Streptococcus pneumoniae 70585 hypothetical protein YP_002739891.1 543202 D 488221 CDS YP_002739892.1 225858382 7684948 543324..543443 1 NC_012468.1 hypothetical protein 543443 7684948 SP70585_0604 Streptococcus pneumoniae 70585 hypothetical protein YP_002739892.1 543324 D 488221 CDS YP_002739893.1 225858383 7683086 543778..543957 1 NC_012468.1 hypothetical protein 543957 7683086 SP70585_0605 Streptococcus pneumoniae 70585 hypothetical protein YP_002739893.1 543778 D 488221 CDS YP_002739894.1 225858384 7683239 544229..544612 1 NC_012468.1 immunity protein BlpX 544612 7683239 SP70585_0606 Streptococcus pneumoniae 70585 immunity protein BlpX YP_002739894.1 544229 D 488221 CDS YP_002739895.1 225858385 7684054 544664..545353 1 NC_012468.1 identified by match to protein family HMM PF02517; BlpY protein 545353 7684054 SP70585_0607 Streptococcus pneumoniae 70585 BlpY protein YP_002739895.1 544664 D 488221 CDS YP_002739896.1 225858386 7682892 545395..545643 1 NC_012468.1 BlpZ 545643 7682892 SP70585_0608 Streptococcus pneumoniae 70585 BlpZ YP_002739896.1 545395 D 488221 CDS YP_002739897.1 225858387 7683251 545673..546284 1 NC_012468.1 identified by match to protein family HMM PF02517; ABC transporter ATP-binding protein 546284 7683251 SP70585_0609 Streptococcus pneumoniae 70585 ABC transporter ATP-binding protein YP_002739897.1 545673 D 488221 CDS YP_002739898.1 225858388 7684336 546446..547240 1 NC_012468.1 identified by match to protein family HMM PF01636; phosphotransferase enzyme family 547240 7684336 SP70585_0610 Streptococcus pneumoniae 70585 phosphotransferase enzyme family YP_002739898.1 546446 D 488221 CDS YP_002739899.1 225858389 7683809 547237..547872 1 NC_012468.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 547872 trmB 7683809 trmB Streptococcus pneumoniae 70585 tRNA (guanine-N(7)-)-methyltransferase YP_002739899.1 547237 D 488221 CDS YP_002739900.1 225858390 7684572 547927..548478 1 NC_012468.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein 548478 7684572 SP70585_0612 Streptococcus pneumoniae 70585 hypothetical protein YP_002739900.1 547927 D 488221 CDS YP_002739901.1 225858391 7683113 548522..549658 1 NC_012468.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 549658 nusA 7683113 nusA Streptococcus pneumoniae 70585 transcription elongation factor NusA YP_002739901.1 548522 D 488221 CDS YP_002739902.1 225858392 7683010 549680..549973 1 NC_012468.1 identified by match to protein family HMM PF04296; putative chain a, hypothetical cytosolic protein coded by gene from nusainfb, ylxr homologue 549973 7683010 SP70585_0614 Streptococcus pneumoniae 70585 putative chain a, hypothetical cytosolic protein coded by gene from nusainfb, ylxr homologue YP_002739902.1 549680 D 488221 CDS YP_002739903.1 225858393 7684659 549966..550265 1 NC_012468.1 identified by match to protein family HMM PF01248; hypothetical protein 550265 7684659 SP70585_0615 Streptococcus pneumoniae 70585 hypothetical protein YP_002739903.1 549966 D 488221 CDS YP_002739904.1 225858394 7682927 550282..553074 1 NC_012468.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 553074 infB 7682927 infB Streptococcus pneumoniae 70585 translation initiation factor IF-2 YP_002739904.1 550282 D 488221 CDS YP_002739905.1 225858395 7683505 553325..553675 1 NC_012468.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A 553675 rbfA 7683505 rbfA Streptococcus pneumoniae 70585 ribosome-binding factor A YP_002739905.1 553325 D 488221 CDS YP_002739906.1 225858396 7683638 complement(553735..554262) 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase 554262 7683638 SP70585_0618 Streptococcus pneumoniae 70585 transposase YP_002739906.1 553735 R 488221 CDS YP_002739907.1 225858397 7682902 complement(554543..555061) 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase 555061 7682902 SP70585_0619 Streptococcus pneumoniae 70585 transposase YP_002739907.1 554543 R 488221 CDS YP_002739908.1 225858398 7683596 556231..556413 1 NC_012468.1 hypothetical protein 556413 7683596 SP70585_0622 Streptococcus pneumoniae 70585 hypothetical protein YP_002739908.1 556231 D 488221 CDS YP_002739909.1 225858399 7683310 556410..556550 1 NC_012468.1 hypothetical protein 556550 7683310 SP70585_0623 Streptococcus pneumoniae 70585 hypothetical protein YP_002739909.1 556410 D 488221 CDS YP_002739910.1 225858400 7684742 556629..557090 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase 557090 7684742 SP70585_0624 Streptococcus pneumoniae 70585 transposase YP_002739910.1 556629 D 488221 CDS YP_002739911.1 225858401 7683578 557102..557479 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01609; transposase (IS4 family) 557479 7683578 SP70585_0625 Streptococcus pneumoniae 70585 transposase (IS4 family) YP_002739911.1 557102 D 488221 CDS YP_002739912.1 225858402 7684099 557691..557924 1 NC_012468.1 identified by match to protein family HMM PF08984; hypothetical protein 557924 7684099 SP70585_0626 Streptococcus pneumoniae 70585 hypothetical protein YP_002739912.1 557691 D 488221 CDS YP_002739913.1 225858403 7684657 557924..559258 1 NC_012468.1 identified by match to protein family HMM PF01814; match to protein family HMM PF04282; hemerythrin HHE cation binding domain subfamily, putative 559258 7684657 SP70585_0627 Streptococcus pneumoniae 70585 hemerythrin HHE cation binding domain subfamily, putative YP_002739913.1 557924 D 488221 CDS YP_002739914.1 225858404 7682899 559268..559522 1 NC_012468.1 identified by match to protein family HMM PF08930; hypothetical protein 559522 7682899 SP70585_0628 Streptococcus pneumoniae 70585 hypothetical protein YP_002739914.1 559268 D 488221 CDS YP_002739915.1 225858405 7683338 559618..560013 1 NC_012468.1 superfamily II helicase 560013 7683338 SP70585_0629 Streptococcus pneumoniae 70585 superfamily II helicase YP_002739915.1 559618 D 488221 CDS YP_002739916.1 225858406 7683854 560426..560875 1 NC_012468.1 conserved protein/domain typically associated with flavoprotein oxygenase, Dim6/ntab family 560875 7683854 SP70585_0630 Streptococcus pneumoniae 70585 conserved protein/domain typically associated with flavoprotein oxygenase, Dim6/ntab family YP_002739916.1 560426 D 488221 CDS YP_002739917.1 225858407 7684594 560862..561422 1 NC_012468.1 identified by match to protein family HMM PF00583; acetyltransferase, gnat family 561422 7684594 SP70585_0631 Streptococcus pneumoniae 70585 acetyltransferase, gnat family YP_002739917.1 560862 D 488221 CDS YP_002739918.1 225858408 7684331 561422..562000 1 NC_012468.1 shikimate kinase 562000 7684331 SP70585_0632 Streptococcus pneumoniae 70585 shikimate kinase YP_002739918.1 561422 D 488221 CDS YP_002739919.1 225858409 7684442 561993..564644 1 NC_012468.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 564644 valS 7684442 valS Streptococcus pneumoniae 70585 valyl-tRNA synthetase YP_002739919.1 561993 D 488221 CDS YP_002739920.1 225858410 7683946 564714..565469 1 NC_012468.1 hypothetical protein 565469 7683946 SP70585_0634 Streptococcus pneumoniae 70585 hypothetical protein YP_002739920.1 564714 D 488221 CDS YP_002739921.1 225858411 7684982 565746..566549 1 NC_012468.1 identified by match to protein family HMM PF02661; Fic protein family 566549 7684982 SP70585_0635 Streptococcus pneumoniae 70585 Fic protein family YP_002739921.1 565746 D 488221 CDS YP_002739922.1 225858412 7683645 complement(567712..567924) 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase 567924 7683645 SP70585_0639 Streptococcus pneumoniae 70585 transposase YP_002739922.1 567712 R 488221 CDS YP_002739923.1 225858413 7683784 568466..569305 1 NC_012468.1 identified by match to protein family HMM PF00874; match to protein family HMM PF03123; transcription antiterminator LicT 569305 7683784 SP70585_0640 Streptococcus pneumoniae 70585 transcription antiterminator LicT YP_002739923.1 568466 D 488221 CDS YP_002739924.1 225858414 7682888 569323..571161 1 NC_012468.1 identified by match to protein family HMM PF00358; match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00830; match to protein family HMM TIGR01995; pts system beta-glucoside-specific eiibca component (eiibca-bgl) (eii-bgl) 571161 7682888 SP70585_0641 Streptococcus pneumoniae 70585 pts system beta-glucoside-specific eiibca component (eiibca-bgl) (eii-bgl) YP_002739924.1 569323 D 488221 CDS YP_002739925.1 225858415 7684647 571174..572589 1 NC_012468.1 identified by match to protein family HMM PF00232; beta-glucosidase (Gentiobiase) (Cellobiase) (Beta-D-glucoside glucohydrolase) (Amygdalase) 572589 7684647 SP70585_0642 Streptococcus pneumoniae 70585 beta-glucosidase (Gentiobiase) (Cellobiase) (Beta-D-glucoside glucohydrolase) (Amygdalase) YP_002739925.1 571174 D 488221 CDS YP_002739926.1 225858416 7683361 573181..574227 1 NC_012468.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 574227 pheS 7683361 pheS Streptococcus pneumoniae 70585 phenylalanyl-tRNA synthetase subunit alpha YP_002739926.1 573181 D 488221 CDS YP_002739927.1 225858417 7684105 574227..574736 1 NC_012468.1 identified by match to protein family HMM PF00583; protease synthase and sporulation negative regulatory protein PAI 1 574736 7684105 SP70585_0644 Streptococcus pneumoniae 70585 protease synthase and sporulation negative regulatory protein PAI 1 YP_002739927.1 574227 D 488221 CDS YP_002739928.1 225858418 7682991 574813..577218 1 NC_012468.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 577218 pheT 7682991 pheT Streptococcus pneumoniae 70585 phenylalanyl-tRNA synthetase subunit beta YP_002739928.1 574813 D 488221 CDS YP_002739929.1 225858419 7683810 complement(577286..578287) 1 NC_012468.1 identified by match to protein family HMM PF03372; endonuclease/exonuclease/phosphatase family 578287 7683810 SP70585_0646 Streptococcus pneumoniae 70585 endonuclease/exonuclease/phosphatase family YP_002739929.1 577286 R 488221 CDS YP_002739930.1 225858420 7684676 578443..578766 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase 578766 7684676 SP70585_0647 Streptococcus pneumoniae 70585 transposase YP_002739930.1 578443 D 488221 CDS YP_002739931.1 225858421 7682961 578763..578891 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase 578891 7682961 SP70585_0648 Streptococcus pneumoniae 70585 transposase YP_002739931.1 578763 D 488221 CDS YP_002739932.1 225858422 7684963 579014..579280 1 NC_012468.1 identified by match to protein family HMM PF01381; helix-turn-helix domain protein 579280 7684963 SP70585_0649 Streptococcus pneumoniae 70585 helix-turn-helix domain protein YP_002739932.1 579014 D 488221 CDS YP_002739933.1 225858423 7682923 579540..581789 1 NC_012468.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 581789 metE 7682923 metE Streptococcus pneumoniae 70585 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase YP_002739933.1 579540 D 488221 CDS YP_002739934.1 225858424 7683739 581853..582719 1 NC_012468.1 identified by match to protein family HMM PF02219; match to protein family HMM TIGR00676; 5,10-methylenetetrahydrofolate reductase 582719 metF 7683739 metF Streptococcus pneumoniae 70585 5,10-methylenetetrahydrofolate reductase YP_002739934.1 581853 D 488221 CDS YP_002739935.1 225858425 7683309 583278..585491 1 NC_012468.1 identified by match to protein family HMM PF00013; match to protein family HMM PF00575; match to protein family HMM PF01138; match to protein family HMM PF03725; match to protein family HMM PF03726; polynucleotide phosphorylase/polyadenylase 585491 7683309 SP70585_0652 Streptococcus pneumoniae 70585 polynucleotide phosphorylase/polyadenylase YP_002739935.1 583278 D 488221 CDS YP_002739936.1 225858426 7683157 585507..586124 1 NC_012468.1 identified by match to protein family HMM TIGR01172; serine O-acetyltransferase 586124 cysE 7683157 cysE Streptococcus pneumoniae 70585 serine O-acetyltransferase YP_002739936.1 585507 D 488221 CDS YP_002739937.1 225858427 7685105 586136..587020 1 NC_012468.1 identified by match to protein family HMM PF00583; acetyltransferase, gnat family 587020 7685105 SP70585_0654 Streptococcus pneumoniae 70585 acetyltransferase, gnat family YP_002739937.1 586136 D 488221 CDS YP_002739938.1 225858428 7684351 587107..588450 1 NC_012468.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 588450 cysS 7684351 cysS Streptococcus pneumoniae 70585 cysteinyl-tRNA synthetase YP_002739938.1 587107 D 488221 CDS YP_002739939.1 225858429 7683073 588443..588829 1 NC_012468.1 identified by match to protein family HMM PF00636; ribonuclease III family protein 588829 7683073 SP70585_0656 Streptococcus pneumoniae 70585 ribonuclease III family protein YP_002739939.1 588443 D 488221 CDS YP_002739940.1 225858430 7683327 588833..589717 1 NC_012468.1 leucine-rich protein 589717 7683327 SP70585_0657 Streptococcus pneumoniae 70585 leucine-rich protein YP_002739940.1 588833 D 488221 CDS YP_002739941.1 225858431 7682937 589854..590309 1 NC_012468.1 hypothetical protein 590309 7682937 SP70585_0658 Streptococcus pneumoniae 70585 hypothetical protein YP_002739941.1 589854 D 488221 CDS YP_002739942.1 225858432 7683013 590306..590452 1 NC_012468.1 hypothetical protein 590452 7683013 SP70585_0659 Streptococcus pneumoniae 70585 hypothetical protein YP_002739942.1 590306 D 488221 CDS YP_002739943.1 225858433 7683154 590598..590771 1 NC_012468.1 GBSi1, group II intron, maturase 590771 7683154 SP70585_0660 Streptococcus pneumoniae 70585 GBSi1, group II intron, maturase YP_002739943.1 590598 D 488221 CDS YP_002739944.1 225858434 7684293 591123..592400 1 NC_012468.1 identified by match to protein family HMM PF02687; peptide ABC transporter permease 592400 7684293 SP70585_0661 Streptococcus pneumoniae 70585 peptide ABC transporter permease YP_002739944.1 591123 D 488221 CDS YP_002739945.1 225858435 7683587 592413..593060 1 NC_012468.1 identified by match to protein family HMM PF00005; peptide ABC transporter ATP-binding protein 593060 7683587 SP70585_0662 Streptococcus pneumoniae 70585 peptide ABC transporter ATP-binding protein YP_002739945.1 592413 D 488221 CDS YP_002739946.1 225858436 7683613 593112..594491 1 NC_012468.1 identified by match to protein family HMM PF02687; peptide ABC transporter permease 594491 7683613 SP70585_0663 Streptococcus pneumoniae 70585 peptide ABC transporter permease YP_002739946.1 593112 D 488221 CDS YP_002739947.1 225858437 7683325 594662..594787 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 594787 7683325 SP70585_0664 Streptococcus pneumoniae 70585 hypothetical protein YP_002739947.1 594662 D 488221 CDS YP_002739948.1 225858438 7683754 594802..595458 1 NC_012468.1 identified by match to protein family HMM PF00072; match to protein family HMM PF00486; VncR, response regulator 595458 7683754 SP70585_0665 Streptococcus pneumoniae 70585 VncR, response regulator YP_002739948.1 594802 D 488221 CDS YP_002739949.1 225858439 7683419 595455..596783 1 NC_012468.1 identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; VncS, histidine kinase 596783 7683419 SP70585_0666 Streptococcus pneumoniae 70585 VncS, histidine kinase YP_002739949.1 595455 D 488221 CDS YP_002739950.1 225858440 7684575 596924..597805 1 NC_012468.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase 597805 fba 7684575 fba Streptococcus pneumoniae 70585 fructose-bisphosphate aldolase YP_002739950.1 596924 D 488221 CDS YP_002739951.1 225858441 7684389 complement(598126..599316) 1 NC_012468.1 identified by match to protein family HMM PF00175; match to protein family HMM PF00970; match to protein family HMM PF01794; oxidoreductase, NAD-binding 599316 7684389 SP70585_0668 Streptococcus pneumoniae 70585 oxidoreductase, NAD-binding YP_002739951.1 598126 R 488221 CDS YP_002739952.1 225858442 7684916 complement(599611..600270) 1 NC_012468.1 identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; glutamine ABC transporter permease 600270 7684916 SP70585_0669 Streptococcus pneumoniae 70585 glutamine ABC transporter permease YP_002739952.1 599611 R 488221 CDS YP_002739953.1 225858443 7684819 complement(600280..600957) 1 NC_012468.1 identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; glutamine ABC transporter permease 600957 7684819 SP70585_0670 Streptococcus pneumoniae 70585 glutamine ABC transporter permease YP_002739953.1 600280 R 488221 CDS YP_002739954.1 225858444 7683292 complement(600970..601734) 1 NC_012468.1 identified by match to protein family HMM PF00497; amino acid ABC transporter substrate-binding protein 601734 7683292 SP70585_0671 Streptococcus pneumoniae 70585 amino acid ABC transporter substrate-binding protein YP_002739954.1 600970 R 488221 CDS YP_002739955.1 225858445 7684507 complement(601774..602532) 1 NC_012468.1 identified by match to protein family HMM PF00005; glutamine transport ATP-binding protein GlnQ 602532 7684507 SP70585_0672 Streptococcus pneumoniae 70585 glutamine transport ATP-binding protein GlnQ YP_002739955.1 601774 R 488221 CDS YP_002739956.1 225858446 7683604 602809..605031 1 NC_012468.1 identified by match to protein family HMM PF01368; match to protein family HMM PF02272; match to protein family HMM TIGR00644; single-stranded-DNA-specific exonuclease RecJ 605031 recJ 7683604 recJ Streptococcus pneumoniae 70585 single-stranded-DNA-specific exonuclease RecJ YP_002739956.1 602809 D 488221 CDS YP_002739957.1 225858447 7683815 605206..606867 1 NC_012468.1 identified by match to protein family HMM PF00753; match to protein family HMM PF07521; metallo-beta-lactamase family protein 606867 7683815 SP70585_0674 Streptococcus pneumoniae 70585 metallo-beta-lactamase family protein YP_002739957.1 605206 D 488221 CDS YP_002739958.1 225858448 7685144 606936..607715 1 NC_012468.1 identified by match to protein family HMM PF00756; tributyrin esterase 607715 7685144 SP70585_0675 Streptococcus pneumoniae 70585 tributyrin esterase YP_002739958.1 606936 D 488221 CDS YP_002739959.1 225858449 7683942 607827..609047 1 NC_012468.1 identified by match to protein family HMM PF02388; serine/alanine-adding enzyme MurM 609047 7683942 SP70585_0676 Streptococcus pneumoniae 70585 serine/alanine-adding enzyme MurM YP_002739959.1 607827 D 488221 CDS YP_002739960.1 225858450 7684552 609052..610284 1 NC_012468.1 identified by match to protein family HMM PF02388; beta-lactam resistance factor 610284 7684552 SP70585_0677 Streptococcus pneumoniae 70585 beta-lactam resistance factor YP_002739960.1 609052 D 488221 CDS YP_002739961.1 225858451 7684793 610363..611064 1 NC_012468.1 identified by match to protein family HMM PF00413; matrixin family 611064 7684793 SP70585_0678 Streptococcus pneumoniae 70585 matrixin family YP_002739961.1 610363 D 488221 CDS YP_002739962.1 225858452 7684697 611104..612948 1 NC_012468.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 612948 uvrC 7684697 uvrC Streptococcus pneumoniae 70585 excinuclease ABC subunit C YP_002739962.1 611104 D 488221 CDS YP_002739963.1 225858453 7684398 612980..613771 1 NC_012468.1 hypothetical protein 613771 7684398 SP70585_0680 Streptococcus pneumoniae 70585 hypothetical protein YP_002739963.1 612980 D 488221 CDS YP_002739964.1 225858454 7682967 complement(613953..614753) 1 NC_012468.1 identified by match to protein family HMM PF00497; ABC transporter substrate-binding protein - glutamine transport/Major cell binding factor 614753 7682967 SP70585_0681 Streptococcus pneumoniae 70585 ABC transporter substrate-binding protein - glutamine transport/Major cell binding factor YP_002739964.1 613953 R 488221 CDS YP_002739965.1 225858455 7684775 614924..615529 1 NC_012468.1 identified by match to protein family HMM PF00881; oxidoreductase 615529 7684775 SP70585_0682 Streptococcus pneumoniae 70585 oxidoreductase YP_002739965.1 614924 D 488221 CDS YP_002739966.1 225858456 7683050 615542..616942 1 NC_012468.1 divalent metal ion-dependent extracellular dipeptidase; able to hydrolyze a broad range of dipeptides but no tri-, tetra-, or larger oligopeptides; differences in the amino acid specificity of the cleavage site varies between species; similar to succinyl-diaminopimelate desuccinylases; dipeptidase PepV 616942 pepV 7683050 pepV Streptococcus pneumoniae 70585 dipeptidase PepV YP_002739966.1 615542 D 488221 CDS YP_002739967.1 225858457 7682971 616996..617574 1 NC_012468.1 identified by match to protein family HMM PF03167; uracil DNA glycosylase family protein 617574 7682971 SP70585_0684 Streptococcus pneumoniae 70585 uracil DNA glycosylase family protein YP_002739967.1 616996 D 488221 CDS YP_002739968.1 225858458 7683271 617734..617886 1 NC_012468.1 hypothetical protein 617886 7683271 SP70585_0685 Streptococcus pneumoniae 70585 hypothetical protein YP_002739968.1 617734 D 488221 CDS YP_002739969.1 225858459 7685045 617902..618021 1 NC_012468.1 molybdopterin biosynthesis MoeB protein 618021 7685045 SP70585_0686 Streptococcus pneumoniae 70585 molybdopterin biosynthesis MoeB protein YP_002739969.1 617902 D 488221 CDS YP_002739970.1 225858460 7683123 618192..619517 1 NC_012468.1 identified by match to protein family HMM PF05525; match to protein family HMM TIGR00796; branched-chain amino acid transport system II carrier protein 619517 brnQ 7683123 brnQ Streptococcus pneumoniae 70585 branched-chain amino acid transport system II carrier protein YP_002739970.1 618192 D 488221 CDS YP_002739971.1 225858461 7683036 619615..620652 1 NC_012468.1 identified by match to protein family HMM PF05343; peptidase, M42 620652 7683036 SP70585_0688 Streptococcus pneumoniae 70585 peptidase, M42 YP_002739971.1 619615 D 488221 CDS YP_002739972.1 225858462 7684239 620654..621115 1 NC_012468.1 identified by match to protein family HMM PF01230; HIT family protein 621115 7684239 SP70585_0689 Streptococcus pneumoniae 70585 HIT family protein YP_002739972.1 620654 D 488221 CDS YP_002739973.1 225858463 7684053 621133..621849 1 NC_012468.1 identified by match to protein family HMM PF02557; D-alanyl-D-alanine carboxypeptidase 621849 7684053 SP70585_0690 Streptococcus pneumoniae 70585 D-alanyl-D-alanine carboxypeptidase YP_002739973.1 621133 D 488221 CDS YP_002739974.1 225858464 7683742 622158..622583 1 NC_012468.1 binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 622583 rplK 7683742 rplK Streptococcus pneumoniae 70585 50S ribosomal protein L11 YP_002739974.1 622158 D 488221 CDS YP_002739975.1 225858465 7683390 622791..623480 1 NC_012468.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 623480 rplA 7683390 rplA Streptococcus pneumoniae 70585 50S ribosomal protein L1 YP_002739975.1 622791 D 488221 CDS YP_002739976.1 225858466 7684296 complement(624126..624317) 1 NC_012468.1 chlorohydrolase 624317 7684296 SP70585_0693 Streptococcus pneumoniae 70585 chlorohydrolase YP_002739976.1 624126 R 488221 CDS YP_002739977.1 225858467 7683863 624475..624693 1 NC_012468.1 hypothetical protein 624693 7683863 SP70585_0694 Streptococcus pneumoniae 70585 hypothetical protein YP_002739977.1 624475 D 488221 CDS YP_002739978.1 225858468 7683003 complement(625572..625703) 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 625703 7683003 SP70585_0695 Streptococcus pneumoniae 70585 hypothetical protein YP_002739978.1 625572 R 488221 CDS YP_002739979.1 225858469 7684453 625737..626729 1 NC_012468.1 identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 626729 7684453 SP70585_0696 Streptococcus pneumoniae 70585 ABC transporter ATP-binding protein YP_002739979.1 625737 D 488221 CDS YP_002739980.1 225858470 7683849 626731..627549 1 NC_012468.1 identified by match to protein family HMM PF06182; membrane protein 627549 7683849 SP70585_0697 Streptococcus pneumoniae 70585 membrane protein YP_002739980.1 626731 D 488221 CDS YP_002739981.1 225858471 7683286 627551..628336 1 NC_012468.1 identified by match to protein family HMM PF06182; ABC transporter permease 628336 7683286 SP70585_0698 Streptococcus pneumoniae 70585 ABC transporter permease YP_002739981.1 627551 D 488221 CDS YP_002739982.1 225858472 7684664 complement(629110..629334) 1 NC_012468.1 hypothetical protein 629334 7684664 SP70585_0701 Streptococcus pneumoniae 70585 hypothetical protein YP_002739982.1 629110 R 488221 CDS YP_002739983.1 225858473 7683728 629567..636001 1 NC_012468.1 identified by match to protein family HMM PF00082; match to protein family HMM PF00746; match to protein family HMM PF02225; match to protein family HMM PF05922; match to protein family HMM PF06280; match to protein family HMM TIGR01167; serine protease 636001 7683728 SP70585_0702 Streptococcus pneumoniae 70585 serine protease YP_002739983.1 629567 D 488221 CDS YP_002739984.1 225858474 7685140 636628..637104 1 NC_012468.1 identified by match to protein family HMM PF00359; phosphotransferase system sugar-specific EII component 637104 7685140 SP70585_0703 Streptococcus pneumoniae 70585 phosphotransferase system sugar-specific EII component YP_002739984.1 636628 D 488221 CDS YP_002739985.1 225858475 7685197 637142..637447 1 NC_012468.1 PTS system, galactose-specific IIB component 637447 7685197 SP70585_0704 Streptococcus pneumoniae 70585 PTS system, galactose-specific IIB component YP_002739985.1 637142 D 488221 CDS YP_002739986.1 225858476 7683685 637495..638970 1 NC_012468.1 identified by match to protein family HMM PF03611; phosphotransferase system sugar-specific EII component 638970 7683685 SP70585_0705 Streptococcus pneumoniae 70585 phosphotransferase system sugar-specific EII component YP_002739986.1 637495 D 488221 CDS YP_002739987.1 225858477 7684860 638996..639142 1 NC_012468.1 chlorohydrolase 639142 7684860 SP70585_0706 Streptococcus pneumoniae 70585 chlorohydrolase YP_002739987.1 638996 D 488221 CDS YP_002739988.1 225858478 7683463 639230..645916 1 NC_012468.1 identified by match to protein family HMM PF00703; match to protein family HMM PF00746; match to protein family HMM PF02836; match to protein family HMM PF02837; match to protein family HMM PF04650; match to protein family HMM PF07501; match to protein family HMM PF07532; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; beta-galactosidase 645916 7683463 SP70585_0707 Streptococcus pneumoniae 70585 beta-galactosidase YP_002739988.1 639230 D 488221 CDS YP_002739989.1 225858479 7684417 complement(646164..646787) 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase 646787 7684417 SP70585_0708 Streptococcus pneumoniae 70585 transposase YP_002739989.1 646164 R 488221 CDS YP_002739990.1 225858480 7685158 complement(646775..647020) 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase 647020 7685158 SP70585_0709 Streptococcus pneumoniae 70585 transposase YP_002739990.1 646775 R 488221 CDS YP_002739991.1 225858481 7684957 complement(647230..647589) 1 NC_012468.1 integral membrane protein 647589 7684957 SP70585_0710 Streptococcus pneumoniae 70585 integral membrane protein YP_002739991.1 647230 R 488221 CDS YP_002739992.1 225858482 7684556 648631..649188 1 NC_012468.1 identified by match to protein family HMM PF06962; SAM-dependent methyltransferase 649188 7684556 SP70585_0713 Streptococcus pneumoniae 70585 SAM-dependent methyltransferase YP_002739992.1 648631 D 488221 CDS YP_002739993.1 225858483 7684740 649181..649435 1 NC_012468.1 hypothetical protein 649435 7684740 SP70585_0714 Streptococcus pneumoniae 70585 hypothetical protein YP_002739993.1 649181 D 488221 CDS YP_002739994.1 225858484 7684875 649447..651501 1 NC_012468.1 identified by match to protein family HMM PF00999; Na+/H+ antiporter 651501 7684875 SP70585_0715 Streptococcus pneumoniae 70585 Na+/H+ antiporter YP_002739994.1 649447 D 488221 CDS YP_002739995.1 225858485 7683194 651680..652540 1 NC_012468.1 identified by match to protein family HMM PF03631; ribonuclease BN 652540 7683194 SP70585_0716 Streptococcus pneumoniae 70585 ribonuclease BN YP_002739995.1 651680 D 488221 CDS YP_002739996.1 225858486 7684662 652751..653461 1 NC_012468.1 identified by match to protein family HMM PF02683; cytoChrome c-type biogenesis protein 653461 7684662 SP70585_0717 Streptococcus pneumoniae 70585 cytoChrome c-type biogenesis protein YP_002739996.1 652751 D 488221 CDS YP_002739997.1 225858487 7685147 653481..654047 1 NC_012468.1 identified by match to protein family HMM PF00578; match to protein family HMM PF08534; thioredoxin family protein 654047 7685147 SP70585_0718 Streptococcus pneumoniae 70585 thioredoxin family protein YP_002739997.1 653481 D 488221 CDS YP_002739998.1 225858488 7683266 654058..655170 1 NC_012468.1 identified by match to protein family HMM PF01625; match to protein family HMM PF01641; match to protein family HMM TIGR00357; match to protein family HMM TIGR00401; peptide methionine sulfoxide reductase MsrA/msrB 655170 7683266 SP70585_0719 Streptococcus pneumoniae 70585 peptide methionine sulfoxide reductase MsrA/msrB YP_002739998.1 654058 D 488221 CDS YP_002739999.1 225858489 7682905 655438..656175 1 NC_012468.1 identified by match to protein family HMM PF00072; match to protein family HMM PF00165; response regulator 656175 7682905 SP70585_0720 Streptococcus pneumoniae 70585 response regulator YP_002739999.1 655438 D 488221 CDS YP_002740000.1 225858490 7684727 656172..657863 1 NC_012468.1 identified by match to protein family HMM PF00672; match to protein family HMM PF02518; match to protein family HMM PF02743; match to protein family HMM PF06580; histidine kinase 657863 7684727 SP70585_0721 Streptococcus pneumoniae 70585 histidine kinase YP_002740000.1 656172 D 488221 CDS YP_002740001.1 225858491 7683017 657979..658542 1 NC_012468.1 identified by match to protein family HMM PF04260; match to protein family HMM TIGR01440; hypothetical protein 658542 7683017 SP70585_0722 Streptococcus pneumoniae 70585 hypothetical protein YP_002740001.1 657979 D 488221 CDS YP_002740002.1 225858492 7684951 658564..664251 1 NC_012468.1 identified by match to protein family HMM PF00746; match to protein family HMM PF05342; match to protein family HMM PF07501; match to protein family HMM PF07580; match to protein family HMM TIGR01167; zinc metalloprotease ZmpB 664251 zmpB 7684951 zmpB Streptococcus pneumoniae 70585 zinc metalloprotease ZmpB YP_002740002.1 658564 D 488221 CDS YP_002740003.1 225858493 7683508 664320..666041 1 NC_012468.1 identified by match to protein family HMM PF00425; match to protein family HMM TIGR00553; chorismate binding enzyme 666041 7683508 SP70585_0724 Streptococcus pneumoniae 70585 chorismate binding enzyme YP_002740003.1 664320 D 488221 CDS YP_002740004.1 225858494 7683652 666042..666659 1 NC_012468.1 hypothetical protein 666659 7683652 SP70585_0725 Streptococcus pneumoniae 70585 hypothetical protein YP_002740004.1 666042 D 488221 CDS YP_002740005.1 225858495 7683229 666709..667707 1 NC_012468.1 identified by match to protein family HMM PF01473; match to protein family HMM PF05901; match to protein family HMM PF07553; hypothetical protein 667707 7683229 SP70585_0726 Streptococcus pneumoniae 70585 hypothetical protein YP_002740005.1 666709 D 488221 CDS YP_002740006.1 225858496 7683075 667834..668793 1 NC_012468.1 identified by match to protein family HMM PF00480; match to protein family HMM TIGR00744; glucokinase (Glucose kinase) 668793 7683075 SP70585_0727 Streptococcus pneumoniae 70585 glucokinase (Glucose kinase) YP_002740006.1 667834 D 488221 CDS YP_002740007.1 225858497 7684630 668890..669729 1 NC_012468.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase 669729 thyA 7684630 thyA Streptococcus pneumoniae 70585 thymidylate synthase YP_002740007.1 668890 D 488221 CDS YP_002740008.1 225858498 7684069 complement(669777..669947) 1 NC_012468.1 hypothetical protein 669947 7684069 SP70585_0729 Streptococcus pneumoniae 70585 hypothetical protein YP_002740008.1 669777 R 488221 CDS YP_002740009.1 225858499 7683892 670044..670952 1 NC_012468.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 670952 miaA 7683892 miaA Streptococcus pneumoniae 70585 tRNA delta(2)-isopentenylpyrophosphate transferase YP_002740009.1 670044 D 488221 CDS YP_002740010.1 225858500 7684528 670945..672183 1 NC_012468.1 identified by match to protein family HMM PF01926; match to protein family HMM TIGR00231; match to protein family HMM TIGR03156; GTP-binding proten HflX 672183 hflX 7684528 hflX Streptococcus pneumoniae 70585 GTP-binding proten HflX YP_002740010.1 670945 D 488221 CDS YP_002740011.1 225858501 7683004 672176..672799 1 NC_012468.1 cystathionine beta-lyase 672799 7683004 SP70585_0732 Streptococcus pneumoniae 70585 cystathionine beta-lyase YP_002740011.1 672176 D 488221 CDS YP_002740012.1 225858502 7684277 672814..673743 1 NC_012468.1 member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions; ribonuclease Z 673743 rnz 7684277 rnz Streptococcus pneumoniae 70585 ribonuclease Z YP_002740012.1 672814 D 488221 CDS YP_002740013.1 225858503 7683369 673764..674519 1 NC_012468.1 identified by match to protein family HMM PF00106; match to protein family HMM PF08659; oxidoreductase 674519 7683369 SP70585_0734 Streptococcus pneumoniae 70585 oxidoreductase YP_002740013.1 673764 D 488221 CDS YP_002740014.1 225858504 7684082 complement(674573..675541) 1 NC_012468.1 identified by match to protein family HMM PF00126; regulatory function on capsule expression 675541 7684082 SP70585_0735 Streptococcus pneumoniae 70585 regulatory function on capsule expression YP_002740014.1 674573 R 488221 CDS YP_002740015.1 225858505 7683872 675545..675814 1 NC_012468.1 identified by match to protein family HMM PF06014; hypothetical protein 675814 7683872 SP70585_0736 Streptococcus pneumoniae 70585 hypothetical protein YP_002740015.1 675545 D 488221 CDS YP_002740016.1 225858506 7683980 675814..676194 1 NC_012468.1 identified by match to protein family HMM PF00581; rhodanese family protein 676194 7683980 SP70585_0737 Streptococcus pneumoniae 70585 rhodanese family protein YP_002740016.1 675814 D 488221 CDS YP_002740017.1 225858507 7684160 676283..676510 1 NC_012468.1 hypothetical protein 676510 7684160 SP70585_0738 Streptococcus pneumoniae 70585 hypothetical protein YP_002740017.1 676283 D 488221 CDS YP_002740018.1 225858508 7683445 complement(676550..677275) 1 NC_012468.1 identified by match to protein family HMM PF00849; match to protein family HMM PF01479; match to protein family HMM TIGR00093; ribosomal small subunit pseudouridine synthase A, putative 677275 7683445 SP70585_0739 Streptococcus pneumoniae 70585 ribosomal small subunit pseudouridine synthase A, putative YP_002740018.1 676550 R 488221 CDS YP_002740019.1 225858509 7685156 677437..679278 1 NC_012468.1 identified by match to protein family HMM PF00009; match to protein family HMM PF00679; match to protein family HMM PF03144; match to protein family HMM TIGR00231; match to protein family HMM TIGR01394; GTP-binding protein TypA/BipA 679278 typA 7685156 typA Streptococcus pneumoniae 70585 GTP-binding protein TypA/BipA YP_002740019.1 677437 D 488221 CDS YP_002740020.1 225858510 7683689 679298..679552 1 NC_012468.1 hypothetical protein 679552 7683689 SP70585_0741 Streptococcus pneumoniae 70585 hypothetical protein YP_002740020.1 679298 D 488221 CDS YP_002740021.1 225858511 7685034 679915..680214 1 NC_012468.1 identified by match to protein family HMM TIGR01653; bacteriocin, lactococcin 972 family 680214 7685034 SP70585_0742 Streptococcus pneumoniae 70585 bacteriocin, lactococcin 972 family YP_002740021.1 679915 D 488221 CDS YP_002740022.1 225858512 7685173 680285..682306 1 NC_012468.1 identified by match to protein family HMM PF07242; match to protein family HMM TIGR01654; bacteriocin-associated integral membrane protein 682306 7685173 SP70585_0743 Streptococcus pneumoniae 70585 bacteriocin-associated integral membrane protein YP_002740022.1 680285 D 488221 CDS YP_002740023.1 225858513 7684971 682308..682949 1 NC_012468.1 identified by match to protein family HMM PF00005; Na+ ABC transporter ATP-binding protein 682949 7684971 SP70585_0744 Streptococcus pneumoniae 70585 Na+ ABC transporter ATP-binding protein YP_002740023.1 682308 D 488221 CDS YP_002740024.1 225858514 7683158 683053..684405 1 NC_012468.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 684405 murD 7683158 murD Streptococcus pneumoniae 70585 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase YP_002740024.1 683053 D 488221 CDS YP_002740025.1 225858515 7682881 684407..685465 1 NC_012468.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; UDP diphospho-muramoyl pentapeptide beta-N acetylglucosaminyl transferase 685465 murG 7682881 murG Streptococcus pneumoniae 70585 UDP diphospho-muramoyl pentapeptide beta-N acetylglucosaminyl transferase YP_002740025.1 684407 D 488221 CDS YP_002740026.1 225858516 7684450 685475..686674 1 NC_012468.1 identified by match to protein family HMM PF03799; match to protein family HMM PF08478; cell division protein DivIB 686674 7684450 SP70585_0747 Streptococcus pneumoniae 70585 cell division protein DivIB YP_002740026.1 685475 D 488221 CDS YP_002740027.1 225858517 7683644 686907..687608 1 NC_012468.1 type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 687608 pyrF 7683644 pyrF Streptococcus pneumoniae 70585 orotidine 5'-phosphate decarboxylase YP_002740027.1 686907 D 488221 CDS YP_002740028.1 225858518 7684042 687642..688274 1 NC_012468.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 688274 pyrE 7684042 pyrE Streptococcus pneumoniae 70585 orotate phosphoribosyltransferase YP_002740028.1 687642 D 488221 CDS YP_002740029.1 225858519 7684230 688735..688857 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 688857 7684230 SP70585_0750 Streptococcus pneumoniae 70585 hypothetical protein YP_002740029.1 688735 D 488221 CDS YP_002740030.1 225858520 7684159 688953..689717 1 NC_012468.1 hypothetical protein 689717 7684159 SP70585_0751 Streptococcus pneumoniae 70585 hypothetical protein YP_002740030.1 688953 D 488221 CDS YP_002740031.1 225858521 7682895 689717..690469 1 NC_012468.1 lipoprotein, putative 690469 7682895 SP70585_0752 Streptococcus pneumoniae 70585 lipoprotein, putative YP_002740031.1 689717 D 488221 CDS YP_002740032.1 225858522 7683517 690473..691177 1 NC_012468.1 hypothetical protein 691177 7683517 SP70585_0753 Streptococcus pneumoniae 70585 hypothetical protein YP_002740032.1 690473 D 488221 CDS YP_002740033.1 225858523 7683454 691174..691821 1 NC_012468.1 identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 691821 7683454 SP70585_0754 Streptococcus pneumoniae 70585 ABC transporter ATP-binding protein YP_002740033.1 691174 D 488221 CDS YP_002740034.1 225858524 7683337 complement(691901..692761) 1 NC_012468.1 identified by match to protein family HMM PF00497; ABC-type amino acid transport/signal transduction system, periplasmic component/domain protein 692761 7683337 SP70585_0755 Streptococcus pneumoniae 70585 ABC-type amino acid transport/signal transduction system, periplasmic component/domain protein YP_002740034.1 691901 R 488221 CDS YP_002740035.1 225858525 7684357 complement(693531..694208) 1 NC_012468.1 identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; glutamine ABC transporter permease 694208 7684357 SP70585_0757 Streptococcus pneumoniae 70585 glutamine ABC transporter permease YP_002740035.1 693531 R 488221 CDS YP_002740036.1 225858526 7683768 complement(694168..694848) 1 NC_012468.1 identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; glutamine ABC transporter permease 694848 7683768 SP70585_0758 Streptococcus pneumoniae 70585 glutamine ABC transporter permease YP_002740036.1 694168 R 488221 CDS YP_002740037.1 225858527 7683995 695064..695210 1 NC_012468.1 hypothetical protein 695210 7683995 SP70585_0759 Streptococcus pneumoniae 70585 hypothetical protein YP_002740037.1 695064 D 488221 CDS YP_002740038.1 225858528 7683135 695338..696828 1 NC_012468.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 696828 lysS 7683135 lysS Streptococcus pneumoniae 70585 lysyl-tRNA synthetase YP_002740038.1 695338 D 488221 CDS YP_002740039.1 225858529 7684894 697452..698588 1 NC_012468.1 identified by match to protein family HMM PF01070; match to protein family HMM TIGR02708; L-lactate oxidase 698588 lctO 7684894 lctO Streptococcus pneumoniae 70585 L-lactate oxidase YP_002740039.1 697452 D 488221 CDS YP_002740040.1 225858530 7684199 699143..699811 1 NC_012468.1 identified by match to protein family HMM PF03070; tena/thi-4 family 699811 7684199 SP70585_0763 Streptococcus pneumoniae 70585 tena/thi-4 family YP_002740040.1 699143 D 488221 CDS YP_002740041.1 225858531 7683473 complement(699808..700035) 1 NC_012468.1 hypothetical protein 700035 7683473 SP70585_0762 Streptococcus pneumoniae 70585 hypothetical protein YP_002740041.1 699808 R 488221 CDS YP_002740042.1 225858532 7684943 700138..700920 1 NC_012468.1 catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP; hydroxyethylthiazole kinase 700920 thiM 7684943 thiM Streptococcus pneumoniae 70585 hydroxyethylthiazole kinase YP_002740042.1 700138 D 488221 CDS YP_002740043.1 225858533 7683409 700922..701551 1 NC_012468.1 identified by match to protein family HMM PF02581; match to protein family HMM TIGR00693; thiamine-phosphate pyrophosphorylase 701551 thiE1 7683409 thiE1 Streptococcus pneumoniae 70585 thiamine-phosphate pyrophosphorylase YP_002740043.1 700922 D 488221 CDS YP_002740044.1 225858534 7685068 702109..702669 1 NC_012468.1 cobalt ABC transporter permease 702669 7685068 SP70585_0766 Streptococcus pneumoniae 70585 cobalt ABC transporter permease YP_002740044.1 702109 D 488221 CDS YP_002740045.1 225858535 7683745 702670..704055 1 NC_012468.1 identified by match to protein family HMM PF00005; cobalt ABC transporter ATP-binding protein 704055 7683745 SP70585_0767 Streptococcus pneumoniae 70585 cobalt ABC transporter ATP-binding protein YP_002740045.1 702670 D 488221 CDS YP_002740046.1 225858536 7683418 704057..704707 1 NC_012468.1 hypothetical protein 704707 7683418 SP70585_0768 Streptococcus pneumoniae 70585 hypothetical protein YP_002740046.1 704057 D 488221 CDS YP_002740047.1 225858537 7683709 704718..705410 1 NC_012468.1 identified by match to protein family HMM PF03070; tena/thi-4 family 705410 7683709 SP70585_0769 Streptococcus pneumoniae 70585 tena/thi-4 family YP_002740047.1 704718 D 488221 CDS YP_002740048.1 225858538 7684991 705415..705939 1 NC_012468.1 identified by match to protein family HMM TIGR02359; ThiW protein 705939 thiW 7684991 thiW Streptococcus pneumoniae 70585 ThiW protein YP_002740048.1 705415 D 488221 CDS YP_002740049.1 225858539 7683153 705939..706742 1 NC_012468.1 identified by match to protein family HMM PF02110; hydroxyethylthiazole kinase 706742 7683153 SP70585_0771 Streptococcus pneumoniae 70585 hydroxyethylthiazole kinase YP_002740049.1 705939 D 488221 CDS YP_002740050.1 225858540 7682994 706735..707367 1 NC_012468.1 Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate; thiamine-phosphate pyrophosphorylase 707367 thiE 7682994 thiE Streptococcus pneumoniae 70585 thiamine-phosphate pyrophosphorylase YP_002740050.1 706735 D 488221 CDS YP_002740051.1 225858541 7683789 complement(707576..708367) 1 NC_012468.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase 708367 thiD 7683789 thiD Streptococcus pneumoniae 70585 phosphomethylpyrimidine kinase YP_002740051.1 707576 R 488221 CDS YP_002740052.1 225858542 7685033 708733..709128 1 NC_012468.1 identified by match to protein family HMM PF03965; match to protein family HMM TIGR02698; copper transport repressor, CopY/TcrY family 709128 7685033 SP70585_0774 Streptococcus pneumoniae 70585 copper transport repressor, CopY/TcrY family YP_002740052.1 708733 D 488221 CDS YP_002740053.1 225858543 7684968 709139..709510 1 NC_012468.1 hypothetical protein 709510 7684968 SP70585_0775 Streptococcus pneumoniae 70585 hypothetical protein YP_002740053.1 709139 D 488221 CDS YP_002740054.1 225858544 7685112 709520..711763 1 NC_012468.1 identified by match to protein family HMM PF00122; match to protein family HMM PF00702; match to protein family HMM PF08282; match to protein family HMM TIGR01494; match to protein family HMM TIGR01511; match to protein family HMM TIGR01525; copper-translocating P-type ATPase 711763 7685112 SP70585_0776 Streptococcus pneumoniae 70585 copper-translocating P-type ATPase YP_002740054.1 709520 D 488221 CDS YP_002740055.1 225858545 7683145 711970..713745 1 NC_012468.1 identified by match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; match to protein family HMM TIGR02720; pyruvate oxidase 713745 spxB 7683145 spxB Streptococcus pneumoniae 70585 pyruvate oxidase YP_002740055.1 711970 D 488221 CDS YP_002740056.1 225858546 7683575 713856..714203 1 NC_012468.1 identified by match to protein family HMM PF00903; glyoxalase family protein 714203 7683575 SP70585_0778 Streptococcus pneumoniae 70585 glyoxalase family protein YP_002740056.1 713856 D 488221 CDS YP_002740057.1 225858547 7683303 complement(714320..714829) 1 NC_012468.1 transposase family protein 714829 7683303 SP70585_0779 Streptococcus pneumoniae 70585 transposase family protein YP_002740057.1 714320 R 488221 CDS YP_002740058.1 225858548 7683141 complement(714861..715265) 1 NC_012468.1 transposase 715265 7683141 SP70585_0780 Streptococcus pneumoniae 70585 transposase YP_002740058.1 714861 R 488221 CDS YP_002740059.1 225858549 7684849 715537..715833 1 NC_012468.1 6-phospho-beta-glucosidase AscB 715833 7684849 SP70585_0781 Streptococcus pneumoniae 70585 6-phospho-beta-glucosidase AscB YP_002740059.1 715537 D 488221 CDS YP_002740060.1 225858550 7683193 715954..716898 1 NC_012468.1 identified by match to protein family HMM PF01238; match to protein family HMM TIGR00218; mannose-6-phosphate isomerase, class I 716898 manA 7683193 manA Streptococcus pneumoniae 70585 mannose-6-phosphate isomerase, class I YP_002740060.1 715954 D 488221 CDS YP_002740061.1 225858551 7683315 complement(719284..719700) 1 NC_012468.1 identified by match to protein family HMM PF00293; MutT/nudix family protein 719700 7683315 SP70585_0786 Streptococcus pneumoniae 70585 MutT/nudix family protein YP_002740061.1 719284 R 488221 CDS YP_002740062.1 225858552 7683837 complement(719759..720934) 1 NC_012468.1 identified by match to protein family HMM PF03486; match to protein family HMM TIGR00275; hypothetical protein 720934 7683837 SP70585_0787 Streptococcus pneumoniae 70585 hypothetical protein YP_002740062.1 719759 R 488221 CDS YP_002740063.1 225858553 7683349 complement(720993..721838) 1 NC_012468.1 identified by match to protein family HMM PF02645; hypothetical protein 721838 7683349 SP70585_0788 Streptococcus pneumoniae 70585 hypothetical protein YP_002740063.1 720993 R 488221 CDS YP_002740064.1 225858554 7683209 721963..722520 1 NC_012468.1 identified by match to protein family HMM PF00440; TetR family transcriptional regulator 722520 7683209 SP70585_0789 Streptococcus pneumoniae 70585 TetR family transcriptional regulator YP_002740064.1 721963 D 488221 CDS YP_002740065.1 225858555 7683605 722539..723006 1 NC_012468.1 identified by match to protein family HMM PF00383; ComE operon protein 2 723006 7683605 SP70585_0790 Streptococcus pneumoniae 70585 ComE operon protein 2 YP_002740065.1 722539 D 488221 CDS YP_002740066.1 225858556 7683147 723074..723724 1 NC_012468.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 723724 upp 7683147 upp Streptococcus pneumoniae 70585 uracil phosphoribosyltransferase YP_002740066.1 723074 D 488221 CDS YP_002740067.1 225858557 7685058 723899..724489 1 NC_012468.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 724489 clpP 7685058 clpP Streptococcus pneumoniae 70585 ATP-dependent Clp protease proteolytic subunit YP_002740067.1 723899 D 488221 CDS YP_002740068.1 225858558 7684713 724568..724816 1 NC_012468.1 hypothetical protein 724816 7684713 SP70585_0793 Streptococcus pneumoniae 70585 hypothetical protein YP_002740068.1 724568 D 488221 CDS YP_002740069.1 225858559 7683778 724917..726077 1 NC_012468.1 identified by match to protein family HMM PF01094; ABC transporter substrate-binding protein - branched chain amino acid transport 726077 7683778 SP70585_0794 Streptococcus pneumoniae 70585 ABC transporter substrate-binding protein - branched chain amino acid transport YP_002740069.1 724917 D 488221 CDS YP_002740070.1 225858560 7683414 726345..727214 1 NC_012468.1 identified by match to protein family HMM PF02653; high-affinity branched-chain amino acid transport system permeaseprotein LivH (LIV-I protein H) 727214 7683414 SP70585_0795 Streptococcus pneumoniae 70585 high-affinity branched-chain amino acid transport system permeaseprotein LivH (LIV-I protein H) YP_002740070.1 726345 D 488221 CDS YP_002740071.1 225858561 7683710 727218..728174 1 NC_012468.1 identified by match to protein family HMM PF02653; branched-chain amino acid ABC transporter permease 728174 7683710 SP70585_0796 Streptococcus pneumoniae 70585 branched-chain amino acid ABC transporter permease YP_002740071.1 727218 D 488221 CDS YP_002740072.1 225858562 7682997 728174..728938 1 NC_012468.1 identified by match to protein family HMM PF00005; high-affinity branched-chain amino acid transport ATP-binding proteinlivG (LIV-I protein G) 728938 7682997 SP70585_0797 Streptococcus pneumoniae 70585 high-affinity branched-chain amino acid transport ATP-binding proteinlivG (LIV-I protein G) YP_002740072.1 728174 D 488221 CDS YP_002740073.1 225858563 7683164 728938..729648 1 NC_012468.1 identified by match to protein family HMM PF00005; high-affinity branched-chain amino acid transport ATP-binding proteinlivF (LIV-I protein F) 729648 7683164 SP70585_0798 Streptococcus pneumoniae 70585 high-affinity branched-chain amino acid transport ATP-binding proteinlivF (LIV-I protein F) YP_002740073.1 728938 D 488221 CDS YP_002740074.1 225858564 7685086 730007..730663 1 NC_012468.1 identified by match to protein family HMM PF00571; AcuB family protein 730663 7685086 SP70585_0799 Streptococcus pneumoniae 70585 AcuB family protein YP_002740074.1 730007 D 488221 CDS YP_002740075.1 225858565 7684370 730876..731865 1 NC_012468.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 731865 prfB 7684370 prfB Streptococcus pneumoniae 70585 peptide chain release factor 2 YP_002740075.1 730876 D 488221 CDS YP_002740076.1 225858566 7683861 731883..732575 1 NC_012468.1 identified by match to protein family HMM PF00005; match to protein family HMM TIGR02673; cell division ATP-binding protein FtsE 732575 ftsE 7683861 ftsE Streptococcus pneumoniae 70585 cell division ATP-binding protein FtsE YP_002740076.1 731883 D 488221 CDS YP_002740077.1 225858567 7683127 732568..733494 1 NC_012468.1 identified by match to protein family HMM PF02687; cell division ABC transporter permease FtsX 733494 7683127 SP70585_0802 Streptococcus pneumoniae 70585 cell division ABC transporter permease FtsX YP_002740077.1 732568 D 488221 CDS YP_002740078.1 225858568 7684400 733780..735960 1 NC_012468.1 identified by match to protein family HMM PF00358; match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826; match to protein family HMM TIGR00830; match to protein family HMM TIGR02003; pts system, iibc component 735960 7684400 SP70585_0803 Streptococcus pneumoniae 70585 pts system, iibc component YP_002740078.1 733780 D 488221 CDS YP_002740079.1 225858569 7682885 736012..736827 1 NC_012468.1 identified by match to protein family HMM PF03372; metal-dependent hydrolase 736827 7682885 SP70585_0804 Streptococcus pneumoniae 70585 metal-dependent hydrolase YP_002740079.1 736012 D 488221 CDS YP_002740080.1 225858570 7685088 736967..738310 1 NC_012468.1 identified by match to protein family HMM PF00270; match to protein family HMM PF00271; superfamily II DNA and RNA helicase 738310 7685088 SP70585_0805 Streptococcus pneumoniae 70585 superfamily II DNA and RNA helicase YP_002740080.1 736967 D 488221 CDS YP_002740081.1 225858571 7684730 738687..739877 1 NC_012468.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 739877 metK 7684730 metK Streptococcus pneumoniae 70585 S-adenosylmethionine synthetase YP_002740081.1 738687 D 488221 CDS YP_002740082.1 225858572 7682984 740430..741365 1 NC_012468.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; subclass 1A is a dimer formed by two identical PyrD subunits each containing an FMN group; dihydroorotate dehydrogenase 1A 741365 7682984 SP70585_0807 Streptococcus pneumoniae 70585 dihydroorotate dehydrogenase 1A YP_002740082.1 740430 D 488221 CDS YP_002740083.1 225858573 7683658 741399..742436 1 NC_012468.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta 742436 holA 7683658 holA Streptococcus pneumoniae 70585 DNA polymerase III subunit delta YP_002740083.1 741399 D 488221 CDS YP_002740084.1 225858574 7682891 742609..743214 1 NC_012468.1 identified by match to protein family HMM PF00081; match to protein family HMM PF02777; superoxide dismutase [Mn] (General stress protein 24)(GSP24) 743214 7682891 SP70585_0809 Streptococcus pneumoniae 70585 superoxide dismutase [Mn] (General stress protein 24)(GSP24) YP_002740084.1 742609 D 488221 CDS YP_002740085.1 225858575 7683274 743370..743900 1 NC_012468.1 identified by match to protein family HMM PF06265; transcriptional regulator 743900 7683274 SP70585_0810 Streptococcus pneumoniae 70585 transcriptional regulator YP_002740085.1 743370 D 488221 CDS YP_002740086.1 225858576 7684562 743921..745006 1 NC_012468.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance; ribosomal RNA large subunit methyltransferase N 745006 7684562 SP70585_0811 Streptococcus pneumoniae 70585 ribosomal RNA large subunit methyltransferase N YP_002740086.1 743921 D 488221 CDS YP_002740087.1 225858577 7685002 745006..745488 1 NC_012468.1 identified by match to protein family HMM PF04892; VanZ family protein 745488 7685002 SP70585_0812 Streptococcus pneumoniae 70585 VanZ family protein YP_002740087.1 745006 D 488221 CDS YP_002740088.1 225858578 7683807 745490..747031 1 NC_012468.1 identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 747031 7683807 SP70585_0813 Streptococcus pneumoniae 70585 ABC transporter ATP-binding protein YP_002740088.1 745490 D 488221 CDS YP_002740089.1 225858579 7683410 complement(747088..747891) 1 NC_012468.1 identified by match to protein family HMM PF00160; peptidyl-prolyl cis-trans isomerase, cyclophilin-type 747891 7683410 SP70585_0814 Streptococcus pneumoniae 70585 peptidyl-prolyl cis-trans isomerase, cyclophilin-type YP_002740089.1 747088 R 488221 CDS YP_002740090.1 225858580 7683160 complement(747974..748186) 1 NC_012468.1 hypothetical protein 748186 7683160 SP70585_0815 Streptococcus pneumoniae 70585 hypothetical protein YP_002740090.1 747974 R 488221 CDS YP_002740091.1 225858581 7683600 complement(748665..748874) 1 NC_012468.1 hypothetical protein 748874 7683600 SP70585_0816 Streptococcus pneumoniae 70585 hypothetical protein YP_002740091.1 748665 R 488221 CDS YP_002740092.1 225858582 7685192 749044..749316 1 NC_012468.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 749316 rpsP 7685192 rpsP Streptococcus pneumoniae 70585 30S ribosomal protein S16 YP_002740092.1 749044 D 488221 CDS YP_002740093.1 225858583 7685123 749336..749575 1 NC_012468.1 hypothetical protein 749575 7685123 SP70585_0818 Streptococcus pneumoniae 70585 hypothetical protein YP_002740093.1 749336 D 488221 CDS YP_002740094.1 225858584 7684844 750152..750940 1 NC_012468.1 identified by match to protein family HMM PF00561; hydrolase, alpha/beta fold family, putative 750940 7684844 SP70585_0819 Streptococcus pneumoniae 70585 hydrolase, alpha/beta fold family, putative YP_002740094.1 750152 D 488221 CDS YP_002740095.1 225858585 7685138 750971..751489 1 NC_012468.1 Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 751489 rimM 7685138 rimM Streptococcus pneumoniae 70585 16S rRNA-processing protein RimM YP_002740095.1 750971 D 488221 CDS YP_002740096.1 225858586 7683836 751479..752198 1 NC_012468.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 752198 trmD 7683836 trmD Streptococcus pneumoniae 70585 tRNA (guanine-N(1)-)-methyltransferase YP_002740096.1 751479 D 488221 CDS YP_002740097.1 225858587 7684361 752210..752548 1 NC_012468.1 identified by match to protein family HMM PF03477; oxygen-sensitive ribonucleoside-triphosphate reductase 752548 7684361 SP70585_0822 Streptococcus pneumoniae 70585 oxygen-sensitive ribonucleoside-triphosphate reductase YP_002740097.1 752210 D 488221 CDS YP_002740098.1 225858588 7683168 complement(752579..752899) 1 NC_012468.1 hypothetical protein 752899 7683168 SP70585_0823 Streptococcus pneumoniae 70585 hypothetical protein YP_002740098.1 752579 R 488221 CDS YP_002740099.1 225858589 7683470 752997..753212 1 NC_012468.1 hypothetical protein 753212 7683470 SP70585_0825 Streptococcus pneumoniae 70585 hypothetical protein YP_002740099.1 752997 D 488221 CDS YP_002740100.1 225858590 7684251 complement(753209..753355) 1 NC_012468.1 chlorohydrolase 753355 7684251 SP70585_0824 Streptococcus pneumoniae 70585 chlorohydrolase YP_002740100.1 753209 R 488221 CDS YP_002740101.1 225858591 7684354 complement(753417..753953) 1 NC_012468.1 identified by match to protein family HMM PF02632; biotin synthase 753953 7684354 SP70585_0826 Streptococcus pneumoniae 70585 biotin synthase YP_002740101.1 753417 R 488221 CDS YP_002740102.1 225858592 7683056 complement(754150..755496) 1 NC_012468.1 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase 755496 gor 7683056 gor Streptococcus pneumoniae 70585 glutathione reductase YP_002740102.1 754150 R 488221 CDS YP_002740103.1 225858593 7683102 755761..756960 1 NC_012468.1 identified by match to protein family HMM TIGR01730; membrane-fusion protein 756960 7683102 SP70585_0828 Streptococcus pneumoniae 70585 membrane-fusion protein YP_002740103.1 755761 D 488221 CDS YP_002740104.1 225858594 7683825 756944..757645 1 NC_012468.1 identified by match to protein family HMM PF00005; macrolide export ATP-binding/permease MacB 757645 7683825 SP70585_0829 Streptococcus pneumoniae 70585 macrolide export ATP-binding/permease MacB YP_002740104.1 756944 D 488221 CDS YP_002740105.1 225858595 7683336 757647..758906 1 NC_012468.1 identified by match to protein family HMM PF02687; antimicrobial peptide ABC transporter permease 758906 7683336 SP70585_0830 Streptococcus pneumoniae 70585 antimicrobial peptide ABC transporter permease YP_002740105.1 757647 D 488221 CDS YP_002740106.1 225858596 7684253 759030..761027 1 NC_012468.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 761027 metG1 7684253 metG1 Streptococcus pneumoniae 70585 methionyl-tRNA synthetase YP_002740106.1 759030 D 488221 CDS YP_002740107.1 225858597 7683396 761077..761358 1 NC_012468.1 chlorohydrolase 761358 7683396 SP70585_0832 Streptococcus pneumoniae 70585 chlorohydrolase YP_002740107.1 761077 D 488221 CDS YP_002740108.1 225858598 7683947 761448..761768 1 NC_012468.1 identified by match to protein family HMM PF03551; transcriptional regulator, PadR family 761768 7683947 SP70585_0833 Streptococcus pneumoniae 70585 transcriptional regulator, PadR family YP_002740108.1 761448 D 488221 CDS YP_002740109.1 225858599 7684233 761772..762587 1 NC_012468.1 hypothetical protein 762587 7684233 SP70585_0834 Streptococcus pneumoniae 70585 hypothetical protein YP_002740109.1 761772 D 488221 CDS YP_002740110.1 225858600 7683275 762662..763588 1 NC_012468.1 identified by match to protein family HMM PF00248; oxidoreductase, aldo/keto reductase family 763588 7683275 SP70585_0835 Streptococcus pneumoniae 70585 oxidoreductase, aldo/keto reductase family YP_002740110.1 762662 D 488221 CDS YP_002740111.1 225858601 7684714 763684..763920 1 NC_012468.1 hypothetical protein 763920 7684714 SP70585_0836 Streptococcus pneumoniae 70585 hypothetical protein YP_002740111.1 763684 D 488221 CDS YP_002740112.1 225858602 7683510 763913..764611 1 NC_012468.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 764611 fabG 7683510 fabG Streptococcus pneumoniae 70585 3-ketoacyl-ACP reductase YP_002740112.1 763913 D 488221 CDS YP_002740113.1 225858603 7684518 764622..765101 1 NC_012468.1 identified by match to protein family HMM PF00293; MutT/nudix family protein 765101 7684518 SP70585_0838 Streptococcus pneumoniae 70585 MutT/nudix family protein YP_002740113.1 764622 D 488221 CDS YP_002740114.1 225858604 7683716 765109..765837 1 NC_012468.1 identified by match to protein family HMM PF00583; acetyltransferase, gnat family 765837 7683716 SP70585_0839 Streptococcus pneumoniae 70585 acetyltransferase, gnat family YP_002740114.1 765109 D 488221 CDS YP_002740115.1 225858605 7685001 765879..766526 1 NC_012468.1 PEP-utilizing enzyme family protein 766526 7685001 SP70585_0840 Streptococcus pneumoniae 70585 PEP-utilizing enzyme family protein YP_002740115.1 765879 D 488221 CDS YP_002740116.1 225858606 7684226 766501..766941 1 NC_012468.1 identified by match to protein family HMM PF06171; hypothetical protein 766941 7684226 SP70585_0841 Streptococcus pneumoniae 70585 hypothetical protein YP_002740116.1 766501 D 488221 CDS YP_002740117.1 225858607 7683065 767064..769610 1 NC_012468.1 identified by match to protein family HMM PF01433; aminopeptidase N 769610 7683065 SP70585_0842 Streptococcus pneumoniae 70585 aminopeptidase N YP_002740117.1 767064 D 488221 CDS YP_002740118.1 225858608 7684489 769719..770393 1 NC_012468.1 identified by match to protein family HMM PF00072; match to protein family HMM PF00486; transcriptional regulatory protein CiaR 770393 7684489 SP70585_0843 Streptococcus pneumoniae 70585 transcriptional regulatory protein CiaR YP_002740118.1 769719 D 488221 CDS YP_002740119.1 225858609 7683381 770383..771717 1 NC_012468.1 identified by match to protein family HMM PF00512; match to protein family HMM PF02518; sensor protein CiaH 771717 7683381 SP70585_0844 Streptococcus pneumoniae 70585 sensor protein CiaH YP_002740119.1 770383 D 488221 CDS YP_002740120.1 225858610 7685157 complement(771751..772038) 1 NC_012468.1 hypothetical protein 772038 7685157 SP70585_0845 Streptococcus pneumoniae 70585 hypothetical protein YP_002740120.1 771751 R 488221 CDS YP_002740121.1 225858611 7684852 772178..773107 1 NC_012468.1 identified by match to protein family HMM PF01136; protease 773107 7684852 SP70585_0846 Streptococcus pneumoniae 70585 protease YP_002740121.1 772178 D 488221 CDS YP_002740122.1 225858612 7683022 773307..775757 1 NC_012468.1 unwinds DNA; bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon 775757 7683022 SP70585_0847 Streptococcus pneumoniae 70585 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon YP_002740122.1 773307 D 488221 CDS YP_002740123.1 225858613 7683162 775767..777017 1 NC_012468.1 identified by match to protein family HMM PF01098; RodA 777017 7683162 SP70585_0848 Streptococcus pneumoniae 70585 RodA YP_002740123.1 775767 D 488221 CDS YP_002740124.1 225858614 7683576 777028..777582 1 NC_012468.1 identified by match to protein family HMM PF01965; match to protein family HMM TIGR01383; 4-methyl-5(b-hydroxyethyl)-thiazole monophosphate biosynthesis protein 777582 7683576 SP70585_0849 Streptococcus pneumoniae 70585 4-methyl-5(b-hydroxyethyl)-thiazole monophosphate biosynthesis protein YP_002740124.1 777028 D 488221 CDS YP_002740125.1 225858615 7684492 777667..778230 1 NC_012468.1 identified by match to protein family HMM PF00702; match to protein family HMM TIGR01549; phosphoglycolate phosphatase 778230 7684492 SP70585_0850 Streptococcus pneumoniae 70585 phosphoglycolate phosphatase YP_002740125.1 777667 D 488221 CDS YP_002740126.1 225858616 7684404 778245..780191 1 NC_012468.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 780191 gyrB 7684404 gyrB Streptococcus pneumoniae 70585 DNA gyrase subunit B YP_002740126.1 778245 D 488221 CDS YP_002740127.1 225858617 7684907 780273..782000 1 NC_012468.1 acts to negatively regulates ftsZ ring formation by modulating the frequency and position of the ftsZ ring formation; septation ring formation regulator EzrA 782000 ezrA 7684907 ezrA Streptococcus pneumoniae 70585 septation ring formation regulator EzrA YP_002740127.1 780273 D 488221 CDS YP_002740128.1 225858618 7683227 complement(782729..782944) 1 NC_012468.1 identified by match to protein family HMM PF05717; IS66 family element, Orf2 782944 7683227 SP70585_0853 Streptococcus pneumoniae 70585 IS66 family element, Orf2 YP_002740128.1 782729 R 488221 CDS YP_002740129.1 225858619 7683525 complement(783313..783612) 1 NC_012468.1 identified by match to protein family HMM PF08860; hypothetical protein 783612 7683525 SP70585_0854 Streptococcus pneumoniae 70585 hypothetical protein YP_002740129.1 783313 R 488221 CDS YP_002740130.1 225858620 7683595 complement(783777..784232) 1 NC_012468.1 identified by match to protein family HMM PF00293; MutT/nudix family protein 784232 7683595 SP70585_0855 Streptococcus pneumoniae 70585 MutT/nudix family protein YP_002740130.1 783777 R 488221 CDS YP_002740131.1 225858621 7683196 784309..784707 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01710; Spn1, transposase Orf1 784707 7683196 SP70585_0856 Streptococcus pneumoniae 70585 Spn1, transposase Orf1 YP_002740131.1 784309 D 488221 CDS YP_002740132.1 225858622 7683329 784816..784956 1 NC_012468.1 Spn1, transposase Orf2 784956 7683329 SP70585_0857 Streptococcus pneumoniae 70585 Spn1, transposase Orf2 YP_002740132.1 784816 D 488221 CDS YP_002740133.1 225858623 7683835 complement(785466..787724) 1 NC_012468.1 identified by match to protein family HMM PF00004; match to protein family HMM PF02151; match to protein family HMM PF07724; match to protein family HMM PF07728; negative regulator of genetic competence ClpC/mecB 787724 7683835 SP70585_0858 Streptococcus pneumoniae 70585 negative regulator of genetic competence ClpC/mecB YP_002740133.1 785466 R 488221 CDS YP_002740134.1 225858624 7684276 complement(787953..788183) 1 NC_012468.1 identified by match to protein family HMM PF08796; hypothetical protein 788183 7684276 SP70585_0859 Streptococcus pneumoniae 70585 hypothetical protein YP_002740134.1 787953 R 488221 CDS YP_002740135.1 225858625 7685190 788374..789057 1 NC_012468.1 identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; amino acid ABC transporter permease 789057 7685190 SP70585_0860 Streptococcus pneumoniae 70585 amino acid ABC transporter permease YP_002740135.1 788374 D 488221 CDS YP_002740136.1 225858626 7685036 789057..789791 1 NC_012468.1 identified by match to protein family HMM PF00005; glutamine transport ATP-binding protein GlnQ 789791 7685036 SP70585_0861 Streptococcus pneumoniae 70585 glutamine transport ATP-binding protein GlnQ YP_002740136.1 789057 D 488221 CDS YP_002740137.1 225858627 7684440 789924..790802 1 NC_012468.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 790802 7684440 SP70585_0862 Streptococcus pneumoniae 70585 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase YP_002740137.1 789924 D 488221 CDS YP_002740138.1 225858628 7682972 790944..791816 1 NC_012468.1 identified by match to protein family HMM PF01256; match to protein family HMM TIGR00196; putative YjeF homolog, C-terminus 791816 7682972 SP70585_0863 Streptococcus pneumoniae 70585 putative YjeF homolog, C-terminus YP_002740138.1 790944 D 488221 CDS YP_002740139.1 225858629 7683787 792098..792781 1 NC_012468.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A 792781 rpiA 7683787 rpiA Streptococcus pneumoniae 70585 ribose-5-phosphate isomerase A YP_002740139.1 792098 D 488221 CDS YP_002740140.1 225858630 7683116 792795..794006 1 NC_012468.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose; phosphopentomutase 794006 deoB 7683116 deoB Streptococcus pneumoniae 70585 phosphopentomutase YP_002740140.1 792795 D 488221 CDS YP_002740141.1 225858631 7683878 794008..794418 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 794418 7683878 SP70585_0866 Streptococcus pneumoniae 70585 hypothetical protein YP_002740141.1 794008 D 488221 CDS YP_002740142.1 225858632 7682910 794396..794536 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 794536 7682910 SP70585_0867 Streptococcus pneumoniae 70585 hypothetical protein YP_002740142.1 794396 D 488221 CDS YP_002740143.1 225858633 7684686 794552..795361 1 NC_012468.1 catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation; purine nucleoside phosphorylase 795361 7684686 SP70585_0868 Streptococcus pneumoniae 70585 purine nucleoside phosphorylase YP_002740143.1 794552 D 488221 CDS YP_002740144.1 225858634 7684420 796068..796817 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 796817 7684420 SP70585_0870 Streptococcus pneumoniae 70585 hypothetical protein YP_002740144.1 796068 D 488221 CDS YP_002740145.1 225858635 7684048 796842..797354 1 NC_012468.1 hemolysin-related protein 797354 7684048 SP70585_0871 Streptococcus pneumoniae 70585 hemolysin-related protein YP_002740145.1 796842 D 488221 CDS YP_002740146.1 225858636 7684937 798012..798722 1 NC_012468.1 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase 798722 deoD 7684937 deoD Streptococcus pneumoniae 70585 purine nucleoside phosphorylase YP_002740146.1 798012 D 488221 CDS YP_002740147.1 225858637 7683107 complement(798745..799269) 1 NC_012468.1 topology modulation protein 799269 7683107 SP70585_0873 Streptococcus pneumoniae 70585 topology modulation protein YP_002740147.1 798745 R 488221 CDS YP_002740148.1 225858638 7684668 complement(799322..799558) 1 NC_012468.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 799558 rpsT 7684668 rpsT Streptococcus pneumoniae 70585 30S ribosomal protein S20 YP_002740148.1 799322 R 488221 CDS YP_002740149.1 225858639 7683703 complement(799626..800546) 1 NC_012468.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase 800546 coaA 7683703 coaA Streptococcus pneumoniae 70585 pantothenate kinase YP_002740149.1 799626 R 488221 CDS YP_002740150.1 225858640 7683822 800932..801090 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 801090 7683822 SP70585_0876 Streptococcus pneumoniae 70585 hypothetical protein YP_002740150.1 800932 D 488221 CDS YP_002740151.1 225858641 7683393 801319..801900 1 NC_012468.1 identified by match to protein family HMM PF05175; methyltransferase small domain superfamily 801900 7683393 SP70585_0877 Streptococcus pneumoniae 70585 methyltransferase small domain superfamily YP_002740151.1 801319 D 488221 CDS YP_002740152.1 225858642 7683750 801897..803174 1 NC_012468.1 Catalyzes the reversible phosphorolysis of pyrimidines in the nucleotide synthesis salvage pathway; pyrimidine-nucleoside phosphorylase 803174 7683750 SP70585_0878 Streptococcus pneumoniae 70585 pyrimidine-nucleoside phosphorylase YP_002740152.1 801897 D 488221 CDS YP_002740153.1 225858643 7683151 803192..803854 1 NC_012468.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 803854 deoC 7683151 deoC Streptococcus pneumoniae 70585 deoxyribose-phosphate aldolase YP_002740153.1 803192 D 488221 CDS YP_002740154.1 225858644 7685056 803841..804230 1 NC_012468.1 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 804230 cdd1 7685056 cdd1 Streptococcus pneumoniae 70585 cytidine deaminase YP_002740154.1 803841 D 488221 CDS YP_002740155.1 225858645 7684010 804321..805373 1 NC_012468.1 identified by match to protein family HMM PF02608; lipoprotein 805373 7684010 SP70585_0881 Streptococcus pneumoniae 70585 lipoprotein YP_002740155.1 804321 D 488221 CDS YP_002740156.1 225858646 7684216 805517..807052 1 NC_012468.1 identified by match to protein family HMM PF00005; ribose import ATP-binding protein RbsA 807052 7684216 SP70585_0882 Streptococcus pneumoniae 70585 ribose import ATP-binding protein RbsA YP_002740156.1 805517 D 488221 CDS YP_002740157.1 225858647 7684826 807045..808103 1 NC_012468.1 identified by match to protein family HMM PF02653; ribose/galactose ABC transporter permease 808103 7684826 SP70585_0883 Streptococcus pneumoniae 70585 ribose/galactose ABC transporter permease YP_002740157.1 807045 D 488221 CDS YP_002740158.1 225858648 7684561 808106..809062 1 NC_012468.1 identified by match to protein family HMM PF02653; ribose/galactose ABC transporter permease 809062 7684561 SP70585_0884 Streptococcus pneumoniae 70585 ribose/galactose ABC transporter permease YP_002740158.1 808106 D 488221 CDS YP_002740159.1 225858649 7682936 809147..809359 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase 809359 7682936 SP70585_0885 Streptococcus pneumoniae 70585 transposase YP_002740159.1 809147 D 488221 CDS YP_002740160.1 225858650 7683295 809585..810418 1 NC_012468.1 identified by match to protein family HMM PF00665; integrase core domain protein 810418 7683295 SP70585_0886 Streptococcus pneumoniae 70585 integrase core domain protein YP_002740160.1 809585 D 488221 CDS YP_002740161.1 225858651 7683450 complement(810461..811102) 1 NC_012468.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX; putative glycerol-3-phosphate acyltransferase PlsY 811102 7683450 SP70585_0887 Streptococcus pneumoniae 70585 putative glycerol-3-phosphate acyltransferase PlsY YP_002740161.1 810461 R 488221 CDS YP_002740162.1 225858652 7683530 811238..813181 1 NC_012468.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B 813181 parE 7683530 parE Streptococcus pneumoniae 70585 DNA topoisomerase IV subunit B YP_002740162.1 811238 D 488221 CDS YP_002740163.1 225858653 7683064 813302..813427 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 813427 7683064 SP70585_0889 Streptococcus pneumoniae 70585 hypothetical protein YP_002740163.1 813302 D 488221 CDS YP_002740164.1 225858654 7684635 813592..816072 1 NC_012468.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A 816072 parC 7684635 parC Streptococcus pneumoniae 70585 DNA topoisomerase IV subunit A YP_002740164.1 813592 D 488221 CDS YP_002740165.1 225858655 7684690 816204..817226 1 NC_012468.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 817226 ilvE 7684690 ilvE Streptococcus pneumoniae 70585 branched-chain amino acid aminotransferase YP_002740165.1 816204 D 488221 CDS YP_002740166.1 225858656 7684379 817282..817986 1 NC_012468.1 hypothetical protein 817986 7684379 SP70585_0892 Streptococcus pneumoniae 70585 hypothetical protein YP_002740166.1 817282 D 488221 CDS YP_002740167.1 225858657 7685124 818051..818740 1 NC_012468.1 identified by match to protein family HMM PF06149; permease 818740 7685124 SP70585_0893 Streptococcus pneumoniae 70585 permease YP_002740167.1 818051 D 488221 CDS YP_002740168.1 225858658 7684803 818737..819660 1 NC_012468.1 identified by match to protein family HMM PF06166; permease 819660 7684803 SP70585_0894 Streptococcus pneumoniae 70585 permease YP_002740168.1 818737 D 488221 CDS YP_002740169.1 225858659 7683519 819675..820319 1 NC_012468.1 catalyzes the removal of 5-oxoproline from various penultimate amino acid residues except L-proline; pyrrolidone-carboxylate peptidase 820319 pcp 7683519 pcp Streptococcus pneumoniae 70585 pyrrolidone-carboxylate peptidase YP_002740169.1 819675 D 488221 CDS YP_002740170.1 225858660 7683687 820487..820717 1 NC_012468.1 hypothetical protein 820717 7683687 SP70585_0896 Streptococcus pneumoniae 70585 hypothetical protein YP_002740170.1 820487 D 488221 CDS YP_002740171.1 225858661 7683915 821090..822292 1 NC_012468.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 822292 rpsA 7683915 rpsA Streptococcus pneumoniae 70585 30S ribosomal protein S1 YP_002740171.1 821090 D 488221 CDS YP_002740172.1 225858662 7684734 complement(822376..822894) 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase 822894 7684734 SP70585_0900 Streptococcus pneumoniae 70585 transposase YP_002740172.1 822376 R 488221 CDS YP_002740173.1 225858663 7684680 complement(823175..823693) 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase 823693 7684680 SP70585_0901 Streptococcus pneumoniae 70585 transposase YP_002740173.1 823175 R 488221 CDS YP_002740174.1 225858664 7682918 823886..824383 1 NC_012468.1 GAF domain-containing protein 824383 7682918 SP70585_0902 Streptococcus pneumoniae 70585 GAF domain-containing protein YP_002740174.1 823886 D 488221 CDS YP_002740175.1 225858665 7684798 824383..826038 1 NC_012468.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 826038 7684798 SP70585_0903 Streptococcus pneumoniae 70585 DNA polymerase III subunits gamma and tau YP_002740175.1 824383 D 488221 CDS YP_002740176.1 225858666 7684901 826066..826260 1 NC_012468.1 hypothetical protein 826260 7684901 SP70585_0904 Streptococcus pneumoniae 70585 hypothetical protein YP_002740176.1 826066 D 488221 CDS YP_002740177.1 225858667 7683416 826410..827180 1 NC_012468.1 identified by match to protein family HMM PF00005; match to protein family HMM TIGR01978; FeS assembly ATPase SufC 827180 sufC 7683416 sufC Streptococcus pneumoniae 70585 FeS assembly ATPase SufC YP_002740177.1 826410 D 488221 CDS YP_002740178.1 225858668 7684002 827208..828470 1 NC_012468.1 identified by match to protein family HMM PF01458; match to protein family HMM TIGR01981; FeS assembly protein SufD 828470 sufD 7684002 sufD Streptococcus pneumoniae 70585 FeS assembly protein SufD YP_002740178.1 827208 D 488221 CDS YP_002740179.1 225858669 7684536 828481..829707 1 NC_012468.1 identified by match to protein family HMM PF00266; match to protein family HMM PF01212; match to protein family HMM TIGR01979; cysteine desulfurase (Selenocysteine lyase) (Selenocysteine reductase) (Selenocysteine beta-lyase) (SCL) 829707 7684536 SP70585_0907 Streptococcus pneumoniae 70585 cysteine desulfurase (Selenocysteine lyase) (Selenocysteine reductase) (Selenocysteine beta-lyase) (SCL) YP_002740179.1 828481 D 488221 CDS YP_002740180.1 225858670 7683236 829694..830134 1 NC_012468.1 identified by match to protein family HMM PF01592; match to protein family HMM TIGR01994; SUF system FeS assembly protein, NifU family 830134 7683236 SP70585_0908 Streptococcus pneumoniae 70585 SUF system FeS assembly protein, NifU family YP_002740180.1 829694 D 488221 CDS YP_002740181.1 225858671 7684475 830188..831600 1 NC_012468.1 identified by match to protein family HMM PF01458; match to protein family HMM TIGR01980; FeS assembly protein SufB 831600 sufB 7684475 sufB Streptococcus pneumoniae 70585 FeS assembly protein SufB YP_002740181.1 830188 D 488221 CDS YP_002740182.1 225858672 7683511 complement(831799..833040) 1 NC_012468.1 identified by match to protein family HMM PF00144; match to protein family HMM PF00768; match to protein family HMM PF07943; D-alanyl-D-alanine carboxypeptidase 833040 7683511 SP70585_0910 Streptococcus pneumoniae 70585 D-alanyl-D-alanine carboxypeptidase YP_002740182.1 831799 R 488221 CDS YP_002740183.1 225858673 7683052 833221..834252 1 NC_012468.1 identified by match to protein family HMM PF01594; membrane protein 834252 7683052 SP70585_0911 Streptococcus pneumoniae 70585 membrane protein YP_002740183.1 833221 D 488221 CDS YP_002740184.1 225858674 7684307 835565..836305 1 NC_012468.1 identified by match to protein family HMM PF00455; match to protein family HMM PF08220; match to protein family HMM PF08279; lactose phosphotransferase system repressor 836305 7684307 SP70585_0913 Streptococcus pneumoniae 70585 lactose phosphotransferase system repressor YP_002740184.1 835565 D 488221 CDS YP_002740185.1 225858675 7684641 836302..837213 1 NC_012468.1 identified by match to protein family HMM PF00294; match to protein family HMM TIGR03168; 1-phosphofructokinase 837213 pfkB 7684641 pfkB Streptococcus pneumoniae 70585 1-phosphofructokinase YP_002740185.1 836302 D 488221 CDS YP_002740186.1 225858676 7683553 837210..839162 1 NC_012468.1 identified by match to protein family HMM PF00359; match to protein family HMM PF02378; match to protein family HMM PF02379; match to protein family HMM TIGR00829; match to protein family HMM TIGR00848; match to protein family HMM TIGR01427; iiabc fructose/xylitol-pts 839162 7683553 SP70585_0915 Streptococcus pneumoniae 70585 iiabc fructose/xylitol-pts YP_002740186.1 837210 D 488221 CDS YP_002740187.1 225858677 7684219 839326..841551 1 NC_012468.1 identified by match to protein family HMM PF01580; DNA translocase ftsk 841551 7684219 SP70585_0916 Streptococcus pneumoniae 70585 DNA translocase ftsk YP_002740187.1 839326 D 488221 CDS YP_002740188.1 225858678 7684738 complement(841702..842130) 1 NC_012468.1 hypothetical protein 842130 7684738 SP70585_0917 Streptococcus pneumoniae 70585 hypothetical protein YP_002740188.1 841702 R 488221 CDS YP_002740189.1 225858679 7685076 842268..843410 1 NC_012468.1 identified by match to protein family HMM PF00266; cysteine desulfurase 843410 7685076 SP70585_0918 Streptococcus pneumoniae 70585 cysteine desulfurase YP_002740189.1 842268 D 488221 CDS YP_002740190.1 225858680 7684537 843419..844633 1 NC_012468.1 Required for the synthesis of the thiazole moiety; thiamine biosynthesis protein ThiI 844633 thiI 7684537 thiI Streptococcus pneumoniae 70585 thiamine biosynthesis protein ThiI YP_002740190.1 843419 D 488221 CDS YP_002740191.1 225858681 7683035 844770..845594 1 NC_012468.1 identified by match to protein family HMM PF00756; putative esterase superfamily 845594 7683035 SP70585_0920 Streptococcus pneumoniae 70585 putative esterase superfamily YP_002740191.1 844770 D 488221 CDS YP_002740192.1 225858682 7684434 846368..847534 1 NC_012468.1 carbamoylphosphate synthase large subunit 847534 7684434 SP70585_0923 Streptococcus pneumoniae 70585 carbamoylphosphate synthase large subunit YP_002740192.1 846368 D 488221 CDS YP_002740193.1 225858683 7683438 848042..849535 1 NC_012468.1 identified by match to protein family HMM PF02384; type I restriction modification enzyme methylase subunit 849535 7683438 SP70585_0924 Streptococcus pneumoniae 70585 type I restriction modification enzyme methylase subunit YP_002740193.1 848042 D 488221 CDS YP_002740194.1 225858684 7683568 849548..850669 1 NC_012468.1 identified by match to protein family HMM PF01420; type I restriction-modification system, S subunit, putative 850669 7683568 SP70585_0925 Streptococcus pneumoniae 70585 type I restriction-modification system, S subunit, putative YP_002740194.1 849548 D 488221 CDS YP_002740195.1 225858685 7684205 850729..850965 1 NC_012468.1 hypothetical protein 850965 7684205 SP70585_0926 Streptococcus pneumoniae 70585 hypothetical protein YP_002740195.1 850729 D 488221 CDS YP_002740196.1 225858686 7685008 850962..851375 1 NC_012468.1 identified by match to protein family HMM PF05012; match to protein family HMM TIGR01550; prophage maintenance system killer protein 851375 7685008 SP70585_0927 Streptococcus pneumoniae 70585 prophage maintenance system killer protein YP_002740196.1 850962 D 488221 CDS YP_002740197.1 225858687 7685169 851493..852458 1 NC_012468.1 identified by match to protein family HMM PF00589; match to protein family HMM PF02899; integrase/recombinase, phage integrase family 852458 7685169 SP70585_0928 Streptococcus pneumoniae 70585 integrase/recombinase, phage integrase family YP_002740197.1 851493 D 488221 CDS YP_002740198.1 225858688 7684155 852492..853535 1 NC_012468.1 identified by match to protein family HMM PF01420; type I restriction-modification system, S subunit 853535 7684155 SP70585_0929 Streptococcus pneumoniae 70585 type I restriction-modification system, S subunit YP_002740198.1 852492 D 488221 CDS YP_002740199.1 225858689 7684545 853565..856915 1 NC_012468.1 identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM PF04313; match to protein family HMM PF04851; type I restriction-modification system R subunit 856915 7684545 SP70585_0930 Streptococcus pneumoniae 70585 type I restriction-modification system R subunit YP_002740199.1 853565 D 488221 CDS YP_002740200.1 225858690 7683053 857186..857341 1 NC_012468.1 chlorohydrolase 857341 7683053 SP70585_0931 Streptococcus pneumoniae 70585 chlorohydrolase YP_002740200.1 857186 D 488221 CDS YP_002740201.1 225858691 7684539 complement(857457..857927) 1 NC_012468.1 identified by match to protein family HMM PF01316; match to protein family HMM PF02863; arginine repressor 857927 7684539 SP70585_0932 Streptococcus pneumoniae 70585 arginine repressor YP_002740201.1 857457 R 488221 CDS YP_002740202.1 225858692 7683816 complement(857944..860217) 1 NC_012468.1 catalyzes the removal of N-terminal dipeptides when proline is the penultimate residue; x-prolyl-dipeptidyl aminopeptidase 860217 7683816 SP70585_0933 Streptococcus pneumoniae 70585 x-prolyl-dipeptidyl aminopeptidase YP_002740202.1 857944 R 488221 CDS YP_002740203.1 225858693 7683512 860564..863665 1 NC_012468.1 Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. Proposed to be responsible for the synthesis of the lagging strand. In the low GC gram positive bacteria this enzyme is less processive and more error prone than its counterpart in other bacteria.; DNA polymerase III DnaE 863665 dnaE 7683512 dnaE Streptococcus pneumoniae 70585 DNA polymerase III DnaE YP_002740203.1 860564 D 488221 CDS YP_002740204.1 225858694 7683272 863747..864754 1 NC_012468.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 864754 pfkA 7683272 pfkA Streptococcus pneumoniae 70585 6-phosphofructokinase YP_002740204.1 863747 D 488221 CDS YP_002740205.1 225858695 7685127 864813..866318 1 NC_012468.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 866318 pyk 7685127 pyk Streptococcus pneumoniae 70585 pyruvate kinase YP_002740205.1 864813 D 488221 CDS YP_002740206.1 225858696 7684483 868123..868995 1 NC_012468.1 lipoprotein, putative 868995 7684483 SP70585_0937 Streptococcus pneumoniae 70585 lipoprotein, putative YP_002740206.1 868123 D 488221 CDS YP_002740207.1 225858697 7683502 869008..869172 1 NC_012468.1 hypothetical protein 869172 7683502 SP70585_0938 Streptococcus pneumoniae 70585 hypothetical protein YP_002740207.1 869008 D 488221 CDS YP_002740208.1 225858698 7684346 complement(869297..869485) 1 NC_012468.1 mobile genetic element 869485 7684346 SP70585_0939 Streptococcus pneumoniae 70585 mobile genetic element YP_002740208.1 869297 R 488221 CDS YP_002740209.1 225858699 7684241 869628..869939 1 NC_012468.1 hypothetical protein 869939 7684241 SP70585_0940 Streptococcus pneumoniae 70585 hypothetical protein YP_002740209.1 869628 D 488221 CDS YP_002740210.1 225858700 7684256 869943..870551 1 NC_012468.1 hypothetical protein 870551 7684256 SP70585_0941 Streptococcus pneumoniae 70585 hypothetical protein YP_002740210.1 869943 D 488221 CDS YP_002740211.1 225858701 7683528 complement(870681..871496) 1 NC_012468.1 identified by match to protein family HMM PF09323; ABC transporter substrate-binding protein 871496 7683528 SP70585_0942 Streptococcus pneumoniae 70585 ABC transporter substrate-binding protein YP_002740211.1 870681 R 488221 CDS YP_002740212.1 225858702 7684718 complement(871493..872398) 1 NC_012468.1 identified by match to protein family HMM PF03773; membrane protein 872398 7684718 SP70585_0943 Streptococcus pneumoniae 70585 membrane protein YP_002740212.1 871493 R 488221 CDS YP_002740213.1 225858703 7683893 complement(872399..872530) 1 NC_012468.1 hypothetical protein 872530 7683893 SP70585_0944 Streptococcus pneumoniae 70585 hypothetical protein YP_002740213.1 872399 R 488221 CDS YP_002740214.1 225858704 7683243 872788..874104 1 NC_012468.1 identified by match to protein family HMM PF08942; capsular polysaccharide biosynthesis protein, putative 874104 7683243 SP70585_0945 Streptococcus pneumoniae 70585 capsular polysaccharide biosynthesis protein, putative YP_002740214.1 872788 D 488221 CDS YP_002740215.1 225858705 7683083 874206..876335 1 NC_012468.1 identified by match to protein family HMM PF00575; S1 RNA binding domain protein 876335 7683083 SP70585_0946 Streptococcus pneumoniae 70585 S1 RNA binding domain protein YP_002740215.1 874206 D 488221 CDS YP_002740216.1 225858706 7683937 876322..876771 1 NC_012468.1 identified by match to protein family HMM PF03926; hypothetical protein 876771 7683937 SP70585_0947 Streptococcus pneumoniae 70585 hypothetical protein YP_002740216.1 876322 D 488221 CDS YP_002740217.1 225858707 7685153 876866..877102 1 NC_012468.1 identified by match to protein family HMM PF04024; PspC domain family 877102 7685153 SP70585_0948 Streptococcus pneumoniae 70585 PspC domain family YP_002740217.1 876866 D 488221 CDS YP_002740218.1 225858708 7684250 878075..878833 1 NC_012468.1 identified by match to protein family HMM PF00005; bacitracin export ATP-binding protein BceA 878833 7684250 SP70585_0949 Streptococcus pneumoniae 70585 bacitracin export ATP-binding protein BceA YP_002740218.1 878075 D 488221 CDS YP_002740219.1 225858709 7685060 878835..880823 1 NC_012468.1 identified by match to protein family HMM PF02687; antimicrobial peptide ABC transporter permease 880823 7685060 SP70585_0950 Streptococcus pneumoniae 70585 antimicrobial peptide ABC transporter permease YP_002740219.1 878835 D 488221 CDS YP_002740220.1 225858710 7683024 complement(880865..881455) 1 NC_012468.1 identified by match to protein family HMM PF01988; integral membrane protein 881455 7683024 SP70585_0951 Streptococcus pneumoniae 70585 integral membrane protein YP_002740220.1 880865 R 488221 CDS YP_002740221.1 225858711 7683620 complement(881700..882530) 1 NC_012468.1 transposase 882530 7683620 SP70585_0952 Streptococcus pneumoniae 70585 transposase YP_002740221.1 881700 R 488221 CDS YP_002740222.1 225858712 7683718 883237..884712 1 NC_012468.1 identified by match to protein family HMM PF00266; match to protein family HMM PF01212; match to protein family HMM PF01276; match to protein family HMM PF03711; arginine decarboxylase 884712 7683718 SP70585_0954 Streptococcus pneumoniae 70585 arginine decarboxylase YP_002740222.1 883237 D 488221 CDS YP_002740223.1 225858713 7683803 complement(884678..885148) 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; pilin gene inverting-related protein 885148 7683803 SP70585_0953 Streptococcus pneumoniae 70585 pilin gene inverting-related protein YP_002740223.1 884678 R 488221 CDS YP_002740224.1 225858714 7684802 complement(885271..885393) 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase 885393 7684802 SP70585_0955 Streptococcus pneumoniae 70585 transposase YP_002740224.1 885271 R 488221 CDS YP_002740225.1 225858715 7684081 885480..885617 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 885617 7684081 SP70585_0956 Streptococcus pneumoniae 70585 hypothetical protein YP_002740225.1 885480 D 488221 CDS YP_002740226.1 225858716 7684157 885648..886508 1 NC_012468.1 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase 886508 speE 7684157 speE Streptococcus pneumoniae 70585 spermidine synthase YP_002740226.1 885648 D 488221 CDS YP_002740227.1 225858717 7683998 886505..887764 1 NC_012468.1 identified by match to protein family HMM PF03435; saccharopine dehydrogenase 887764 lys 7683998 lys Streptococcus pneumoniae 70585 saccharopine dehydrogenase YP_002740227.1 886505 D 488221 CDS YP_002740228.1 225858718 7684341 887764..888891 1 NC_012468.1 identified by match to protein family HMM PF00278; match to protein family HMM TIGR01047; carboxynorspermidine decarboxylase 888891 nspC 7684341 nspC Streptococcus pneumoniae 70585 carboxynorspermidine decarboxylase YP_002740228.1 887764 D 488221 CDS YP_002740229.1 225858719 7682943 888888..889973 1 NC_012468.1 catalyzes the formation of carbamoylputrescine from agmatine in the arginine decarboxylase pathway of putrescine biosynthesis; agmatine deiminase 889973 aguA 7682943 aguA Streptococcus pneumoniae 70585 agmatine deiminase YP_002740229.1 888888 D 488221 CDS YP_002740230.1 225858720 7683014 889983..890858 1 NC_012468.1 identified by match to protein family HMM PF00795; match to protein family HMM TIGR03381; N-carbamoylputrescine amidase 890858 aguB 7683014 aguB Streptococcus pneumoniae 70585 N-carbamoylputrescine amidase YP_002740230.1 889983 D 488221 CDS YP_002740231.1 225858721 7684224 complement(891039..891848) 1 NC_012468.1 identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; Cof family protein 891848 7684224 SP70585_0962 Streptococcus pneumoniae 70585 Cof family protein YP_002740231.1 891039 R 488221 CDS YP_002740232.1 225858722 7684616 892120..892341 1 NC_012468.1 hypothetical protein 892341 7684616 SP70585_0963 Streptococcus pneumoniae 70585 hypothetical protein YP_002740232.1 892120 D 488221 CDS YP_002740233.1 225858723 7684652 892395..893066 1 NC_012468.1 identified by match to protein family HMM PF02517; caax amino protease family 893066 7684652 SP70585_0964 Streptococcus pneumoniae 70585 caax amino protease family YP_002740233.1 892395 D 488221 CDS YP_002740234.1 225858724 7683862 complement(893118..893315) 1 NC_012468.1 hypothetical protein 893315 7683862 SP70585_0965 Streptococcus pneumoniae 70585 hypothetical protein YP_002740234.1 893118 R 488221 CDS YP_002740235.1 225858725 7682973 893308..894216 1 NC_012468.1 identified by match to protein family HMM PF00126; match to protein family HMM PF03466; regulatory function on capsule expression in group B streptococci 894216 7682973 SP70585_0966 Streptococcus pneumoniae 70585 regulatory function on capsule expression in group B streptococci YP_002740235.1 893308 D 488221 CDS YP_002740236.1 225858726 7683486 894213..894674 1 NC_012468.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 894674 lspA 7683486 lspA Streptococcus pneumoniae 70585 lipoprotein signal peptidase YP_002740236.1 894213 D 488221 CDS YP_002740237.1 225858727 7683624 894664..895551 1 NC_012468.1 identified by match to protein family HMM PF00849; match to protein family HMM PF01479; match to protein family HMM TIGR00005; ribosomal large subunit pseudouridine synthase D 895551 rluD 7683624 rluD Streptococcus pneumoniae 70585 ribosomal large subunit pseudouridine synthase D YP_002740237.1 894664 D 488221 CDS YP_002740238.1 225858728 7682894 895554..897437 1 NC_012468.1 identified by match to protein family HMM PF00753; match to protein family HMM PF01473; choline binding protein E 897437 7682894 SP70585_0969 Streptococcus pneumoniae 70585 choline binding protein E YP_002740238.1 895554 D 488221 CDS YP_002740239.1 225858729 7683259 897538..898647 1 NC_012468.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 898647 proB 7683259 proB Streptococcus pneumoniae 70585 gamma-glutamyl kinase YP_002740239.1 897538 D 488221 CDS YP_002740240.1 225858730 7684031 898657..899919 1 NC_012468.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 899919 proA 7684031 proA Streptococcus pneumoniae 70585 gamma-glutamyl phosphate reductase YP_002740240.1 898657 D 488221 CDS YP_002740241.1 225858731 7684934 899923..900720 1 NC_012468.1 identified by match to protein family HMM PF01210; match to protein family HMM PF03446; match to protein family HMM PF03807; match to protein family HMM TIGR00112; pyrroline-5-carboxylate reductase 900720 proC 7684934 proC Streptococcus pneumoniae 70585 pyrroline-5-carboxylate reductase YP_002740241.1 899923 D 488221 CDS YP_002740242.1 225858732 7683476 900940..901578 1 NC_012468.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 901578 tmk 7683476 tmk Streptococcus pneumoniae 70585 thymidylate kinase YP_002740242.1 900940 D 488221 CDS YP_002740243.1 225858733 7683169 901575..902465 1 NC_012468.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA.; DNA polymerase III subunit delta' 902465 7683169 SP70585_0974 Streptococcus pneumoniae 70585 DNA polymerase III subunit delta' YP_002740243.1 901575 D 488221 CDS YP_002740244.1 225858734 7683593 902505..902822 1 NC_012468.1 in Bacillus subtilis this protein is involved in the negative regulation of DNA replication initiation; interacts with DnaN and DnaA; DNA replication intiation control protein YabA 902822 7683593 SP70585_0975 Streptococcus pneumoniae 70585 DNA replication intiation control protein YabA YP_002740244.1 902505 D 488221 CDS YP_002740245.1 225858735 7684772 902825..903694 1 NC_012468.1 identified by match to protein family HMM PF00590; match to protein family HMM TIGR00096; hypothetical protein 903694 7684772 SP70585_0976 Streptococcus pneumoniae 70585 hypothetical protein YP_002740245.1 902825 D 488221 CDS YP_002740246.1 225858736 7684548 903921..904439 1 NC_012468.1 identified by match to protein family HMM PF08020; hypothetical protein 904439 7684548 SP70585_0977 Streptococcus pneumoniae 70585 hypothetical protein YP_002740246.1 903921 D 488221 CDS YP_002740247.1 225858737 7684766 904548..905195 1 NC_012468.1 identified by match to protein family HMM PF06970; phage protein 905195 7684766 SP70585_0979 Streptococcus pneumoniae 70585 phage protein YP_002740247.1 904548 D 488221 CDS YP_002740248.1 225858738 7685103 906481..907815 1 NC_012468.1 TrmFO; Gid; glucose-inhibited division protein; similar to GidA; the gene from Bacillus subtilis encodes a tRNA-methyltransferase that utilizes folate as the carbon donor and bound flavin as reductant; modifies tRNA at position 54 (uridine) of the T-psi loop to form a C5-methyluridine; tRNA (uracil-5-)-methyltransferase Gid 907815 trmFO 7685103 trmFO Streptococcus pneumoniae 70585 tRNA (uracil-5-)-methyltransferase Gid YP_002740248.1 906481 D 488221 CDS YP_002740249.1 225858739 7683378 907899..908636 1 NC_012468.1 Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 908636 pyrH 7683378 pyrH Streptococcus pneumoniae 70585 uridylate kinase YP_002740249.1 907899 D 488221 CDS YP_002740250.1 225858740 7683642 908645..909202 1 NC_012468.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 909202 frr 7683642 frr Streptococcus pneumoniae 70585 ribosome recycling factor YP_002740250.1 908645 D 488221 CDS YP_002740251.1 225858741 7684804 909223..910116 1 NC_012468.1 s1 RNA binding domain protein 910116 7684804 SP70585_0985 Streptococcus pneumoniae 70585 s1 RNA binding domain protein YP_002740251.1 909223 D 488221 CDS YP_002740252.1 225858742 7683783 910125..910340 1 NC_012468.1 identified by match to protein family HMM PF06855; hypothetical protein 910340 7683783 SP70585_0986 Streptococcus pneumoniae 70585 hypothetical protein YP_002740252.1 910125 D 488221 CDS YP_002740253.1 225858743 7684323 910426..911394 1 NC_012468.1 identified by match to protein family HMM PF02562; PhoH family protein 911394 7684323 SP70585_0987 Streptococcus pneumoniae 70585 PhoH family protein YP_002740253.1 910426 D 488221 CDS YP_002740254.1 225858744 7684595 911587..912087 1 NC_012468.1 identified by match to protein family HMM PF00583; acetyltransferase, gnat family 912087 7684595 SP70585_0988 Streptococcus pneumoniae 70585 acetyltransferase, gnat family YP_002740254.1 911587 D 488221 CDS YP_002740255.1 225858745 7683529 912090..912317 1 NC_012468.1 TfoX N- domain family protein 912317 7683529 SP70585_0989 Streptococcus pneumoniae 70585 TfoX N- domain family protein YP_002740255.1 912090 D 488221 CDS YP_002740256.1 225858746 7683888 914005..914574 1 NC_012468.1 identified by match to protein family HMM PF00583; acetyltransferase, gnat family 914574 7683888 SP70585_0993 Streptococcus pneumoniae 70585 acetyltransferase, gnat family YP_002740256.1 914005 D 488221 CDS YP_002740257.1 225858747 7684908 914642..915292 1 NC_012468.1 identified by match to protein family HMM PF00633; match to protein family HMM TIGR00426; match to protein family HMM TIGR01259; competence protein 915292 7684908 SP70585_0994 Streptococcus pneumoniae 70585 competence protein YP_002740257.1 914642 D 488221 CDS YP_002740258.1 225858748 7683616 915276..917516 1 NC_012468.1 identified by match to protein family HMM PF03772; match to protein family HMM TIGR00360; match to protein family HMM TIGR00361; DNA internalization-related competence protein ComEC/Rec2 917516 7683616 SP70585_0995 Streptococcus pneumoniae 70585 DNA internalization-related competence protein ComEC/Rec2 YP_002740258.1 915276 D 488221 CDS YP_002740259.1 225858749 7683538 917658..917882 1 NC_012468.1 hypothetical protein 917882 7683538 SP70585_0996 Streptococcus pneumoniae 70585 hypothetical protein YP_002740259.1 917658 D 488221 CDS YP_002740260.1 225858750 7683234 917914..918501 1 NC_012468.1 identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 918501 7683234 SP70585_0997 Streptococcus pneumoniae 70585 ABC transporter ATP-binding protein YP_002740260.1 917914 D 488221 CDS YP_002740261.1 225858751 7683046 918505..919689 1 NC_012468.1 hypothetical protein 919689 7683046 SP70585_0998 Streptococcus pneumoniae 70585 hypothetical protein YP_002740261.1 918505 D 488221 CDS YP_002740262.1 225858752 7684683 919964..920521 1 NC_012468.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 920521 infC 7684683 infC Streptococcus pneumoniae 70585 translation initiation factor IF-3 YP_002740262.1 919964 D 488221 CDS YP_002740263.1 225858753 7683967 920554..920754 1 NC_012468.1 identified by match to protein family HMM PF01632; match to protein family HMM TIGR00001; 50S ribosomal protein L35 920754 rpmI 7683967 rpmI Streptococcus pneumoniae 70585 50S ribosomal protein L35 YP_002740263.1 920554 D 488221 CDS YP_002740264.1 225858754 7684882 920806..921165 1 NC_012468.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 921165 rplT 7684882 rplT Streptococcus pneumoniae 70585 50S ribosomal protein L20 YP_002740264.1 920806 D 488221 CDS YP_002740265.1 225858755 7684612 921223..921603 1 NC_012468.1 identified by match to protein family HMM PF00903; lactoylglutathione lyase 921603 7684612 SP70585_1002 Streptococcus pneumoniae 70585 lactoylglutathione lyase YP_002740265.1 921223 D 488221 CDS YP_002740266.1 225858756 7683536 921853..922653 1 NC_012468.1 responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the pyrD subunit to the ultimate electron acceptor NAD(+); dihydroorotate dehydrogenase electron transfer subunit 922653 7683536 SP70585_1003 Streptococcus pneumoniae 70585 dihydroorotate dehydrogenase electron transfer subunit YP_002740266.1 921853 D 488221 CDS YP_002740267.1 225858757 7682949 922664..923602 1 NC_012468.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway, using a flavin nucleotide as an essential cofactor; subclass 1B is a heterotetramer consisting of two PyrDB subunits, similar to the PyrDA subunits and two PyrK subunits; dihydroorotate dehydrogenase 1B 923602 7682949 SP70585_1004 Streptococcus pneumoniae 70585 dihydroorotate dehydrogenase 1B YP_002740267.1 922664 D 488221 CDS YP_002740268.1 225858758 7685100 923701..925809 1 NC_012468.1 identified by match to protein family HMM PF01473; match to protein family HMM PF01832; endo-beta-N-acetylglucosaminidase 925809 7685100 SP70585_1005 Streptococcus pneumoniae 70585 endo-beta-N-acetylglucosaminidase YP_002740268.1 923701 D 488221 CDS YP_002740269.1 225858759 7684498 complement(925870..927525) 1 NC_012468.1 identified by match to protein family HMM PF05670; match to protein family HMM PF05833; fibronectin/fibrinogen binding protein 927525 7684498 SP70585_1006 Streptococcus pneumoniae 70585 fibronectin/fibrinogen binding protein YP_002740269.1 925870 R 488221 CDS YP_002740270.1 225858760 7683094 927630..928127 1 NC_012468.1 identified by match to protein family HMM PF02130; match to protein family HMM TIGR00043; putative metalloprotease 928127 7683094 SP70585_1007 Streptococcus pneumoniae 70585 putative metalloprotease YP_002740270.1 927630 D 488221 CDS YP_002740271.1 225858761 7684217 928108..928503 1 NC_012468.1 identified by match to protein family HMM PF01219; diacylglycerol kinase (dagk) (diglyceride kinase)(dgk) 928503 7684217 SP70585_1008 Streptococcus pneumoniae 70585 diacylglycerol kinase (dagk) (diglyceride kinase)(dgk) YP_002740271.1 928108 D 488221 CDS YP_002740272.1 225858762 7682884 928520..929419 1 NC_012468.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 929419 era 7682884 era Streptococcus pneumoniae 70585 GTP-binding protein Era YP_002740272.1 928520 D 488221 CDS YP_002740273.1 225858763 7682957 929468..930292 1 NC_012468.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 930292 mutM 7682957 mutM Streptococcus pneumoniae 70585 formamidopyrimidine-DNA glycosylase YP_002740273.1 929468 D 488221 CDS YP_002740274.1 225858764 7684496 930292..930897 1 NC_012468.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase 930897 coaE 7684496 coaE Streptococcus pneumoniae 70585 dephospho-CoA kinase YP_002740274.1 930292 D 488221 CDS YP_002740275.1 225858765 7683296 930884..932083 1 NC_012468.1 identified by match to protein family HMM PF07690; multidrug resistance protein MdtG 932083 7683296 SP70585_1012 Streptococcus pneumoniae 70585 multidrug resistance protein MdtG YP_002740275.1 930884 D 488221 CDS YP_002740276.1 225858766 7683870 932083..932232 1 NC_012468.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 932232 rpmG 7683870 rpmG Streptococcus pneumoniae 70585 50S ribosomal protein L33 YP_002740276.1 932083 D 488221 CDS YP_002740277.1 225858767 7683386 932272..932505 1 NC_012468.1 identified by match to protein family HMM PF03840; match to protein family HMM TIGR00810; preprotein translocase subunit SecG 932505 secG 7683386 secG Streptococcus pneumoniae 70585 preprotein translocase subunit SecG YP_002740277.1 932272 D 488221 CDS YP_002740278.1 225858768 7684759 932607..934961 1 NC_012468.1 identified by match to protein family HMM PF00575; match to protein family HMM PF00773; match to protein family HMM PF08206; match to protein family HMM TIGR00358; match to protein family HMM TIGR02063; ribonuclease R 934961 rnr 7684759 rnr Streptococcus pneumoniae 70585 ribonuclease R YP_002740278.1 932607 D 488221 CDS YP_002740279.1 225858769 7684547 934924..935391 1 NC_012468.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 935391 smpB 7684547 smpB Streptococcus pneumoniae 70585 SsrA-binding protein YP_002740279.1 934924 D 488221 CDS YP_002740280.1 225858770 7684393 935407..936267 1 NC_012468.1 with TehA confers resistance to tellurite; tellurite resistance protein TehB 936267 tehB 7684393 tehB Streptococcus pneumoniae 70585 tellurite resistance protein TehB YP_002740280.1 935407 D 488221 CDS YP_002740281.1 225858771 7684090 936340..937293 1 NC_012468.1 identified by match to protein family HMM PF06054; competence protein 937293 7684090 SP70585_1018 Streptococcus pneumoniae 70585 competence protein YP_002740281.1 936340 D 488221 CDS YP_002740282.1 225858772 7684996 937312..939114 1 NC_012468.1 identified by match to protein family HMM PF01432; match to protein family HMM PF08439; match to protein family HMM TIGR00181; oligoendopeptidase F 939114 pepF1 7684996 pepF1 Streptococcus pneumoniae 70585 oligoendopeptidase F YP_002740282.1 937312 D 488221 CDS YP_002740283.1 225858773 7683447 939152..939829 1 NC_012468.1 identified by match to protein family HMM PF01596; match to protein family HMM PF08241; O-methyltransferase family protein 939829 7683447 SP70585_1020 Streptococcus pneumoniae 70585 O-methyltransferase family protein YP_002740283.1 939152 D 488221 CDS YP_002740284.1 225858774 7683298 939896..940837 1 NC_012468.1 cis/trans isomerase of peptidylprolyl; PPIase; membrane-bound lipoprotein; foldase PrsA 940837 prsA 7683298 prsA Streptococcus pneumoniae 70585 foldase PrsA YP_002740284.1 939896 D 488221 CDS YP_002740285.1 225858775 7684994 complement(940954..941295) 1 NC_012468.1 transposase OrfB 941295 7684994 SP70585_1022 Streptococcus pneumoniae 70585 transposase OrfB YP_002740285.1 940954 R 488221 CDS YP_002740286.1 225858776 7683963 complement(941295..941486) 1 NC_012468.1 hypothetical protein 941486 7683963 SP70585_1023 Streptococcus pneumoniae 70585 hypothetical protein YP_002740286.1 941295 R 488221 CDS YP_002740287.1 225858777 7682956 941909..942055 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; Spn1, transposase Orf2 942055 7682956 SP70585_1024 Streptococcus pneumoniae 70585 Spn1, transposase Orf2 YP_002740287.1 941909 D 488221 CDS YP_002740288.1 225858778 7683114 complement(942056..942676) 1 NC_012468.1 identified by match to protein family HMM PF00300; phosphoglycerate mutase 942676 7683114 SP70585_1025 Streptococcus pneumoniae 70585 phosphoglycerate mutase YP_002740288.1 942056 R 488221 CDS YP_002740289.1 225858779 7684897 complement(942676..943158) 1 NC_012468.1 identified by match to protein family HMM PF04073; regulatory protein 943158 7684897 SP70585_1026 Streptococcus pneumoniae 70585 regulatory protein YP_002740289.1 942676 R 488221 CDS YP_002740290.1 225858780 7684516 complement(943158..944000) 1 NC_012468.1 identified by match to protein family HMM PF04018; integral membrane protein 944000 7684516 SP70585_1027 Streptococcus pneumoniae 70585 integral membrane protein YP_002740290.1 943158 R 488221 CDS YP_002740291.1 225858781 7684527 complement(944095..944895) 1 NC_012468.1 identified by match to protein family HMM PF01183; lyzozyme M1 944895 7684527 SP70585_1028 Streptococcus pneumoniae 70585 lyzozyme M1 YP_002740291.1 944095 R 488221 CDS YP_002740292.1 225858782 7683487 945039..946418 1 NC_012468.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 946418 glmU 7683487 glmU Streptococcus pneumoniae 70585 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase YP_002740292.1 945039 D 488221 CDS YP_002740293.1 225858783 7683264 946428..946973 1 NC_012468.1 identified by match to protein family HMM PF00293; ADP-ribose pyrophosphatase 946973 7683264 SP70585_1030 Streptococcus pneumoniae 70585 ADP-ribose pyrophosphatase YP_002740293.1 946428 D 488221 CDS YP_002740294.1 225858784 7682933 946985..947299 1 NC_012468.1 hypothetical protein 947299 7682933 SP70585_1031 Streptococcus pneumoniae 70585 hypothetical protein YP_002740294.1 946985 D 488221 CDS YP_002740295.1 225858785 7684682 947316..948008 1 NC_012468.1 enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 948008 mtnN 7684682 mtnN Streptococcus pneumoniae 70585 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase YP_002740295.1 947316 D 488221 CDS YP_002740296.1 225858786 7683755 948097..948576 1 NC_012468.1 identified by match to protein family HMM PF04394; hypothetical protein 948576 7683755 SP70585_1033 Streptococcus pneumoniae 70585 hypothetical protein YP_002740296.1 948097 D 488221 CDS YP_002740297.1 225858787 7683258 948674..949264 1 NC_012468.1 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 949264 7683258 SP70585_1034 Streptococcus pneumoniae 70585 DNA polymerase III subunit epsilon YP_002740297.1 948674 D 488221 CDS YP_002740298.1 225858788 7683069 949273..951036 1 NC_012468.1 identified by match to protein family HMM PF03009; glycerophosphoryl diester phosphodiesterase family protein 951036 7683069 SP70585_1035 Streptococcus pneumoniae 70585 glycerophosphoryl diester phosphodiesterase family protein YP_002740298.1 949273 D 488221 CDS YP_002740299.1 225858789 7684920 951232..951579 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01710; transposase 951579 7684920 SP70585_1036 Streptococcus pneumoniae 70585 transposase YP_002740299.1 951232 D 488221 CDS YP_002740300.1 225858790 7683184 952059..952259 1 NC_012468.1 hypothetical protein 952259 7683184 SP70585_1037 Streptococcus pneumoniae 70585 hypothetical protein YP_002740300.1 952059 D 488221 CDS YP_002740301.1 225858791 7683534 952284..952700 1 NC_012468.1 hypothetical protein 952700 7683534 SP70585_1038 Streptococcus pneumoniae 70585 hypothetical protein YP_002740301.1 952284 D 488221 CDS YP_002740302.1 225858792 7684700 952931..953638 1 NC_012468.1 identified by match to protein family HMM PF02683; cytochrome c-type biogenesis protein CcdA 953638 7684700 SP70585_1039 Streptococcus pneumoniae 70585 cytochrome c-type biogenesis protein CcdA YP_002740302.1 952931 D 488221 CDS YP_002740303.1 225858793 7684202 953649..954206 1 NC_012468.1 identified by match to protein family HMM PF00578; match to protein family HMM PF08534; thioredoxin family protein 954206 7684202 SP70585_1040 Streptococcus pneumoniae 70585 thioredoxin family protein YP_002740303.1 953649 D 488221 CDS YP_002740304.1 225858794 7685097 954580..955971 1 NC_012468.1 identified by match to protein family HMM PF00324; amino acid permease family protein 955971 7685097 SP70585_1041 Streptococcus pneumoniae 70585 amino acid permease family protein YP_002740304.1 954580 D 488221 CDS YP_002740305.1 225858795 7682948 956114..957031 1 NC_012468.1 identified by match to protein family HMM PF01297; zinc-binding lipoprotein AdcA 957031 7682948 SP70585_1042 Streptococcus pneumoniae 70585 zinc-binding lipoprotein AdcA YP_002740305.1 956114 D 488221 CDS YP_002740306.1 225858796 7683324 957039..959600 1 NC_012468.1 identified by match to protein family HMM PF04270; match to protein family HMM TIGR01363; pneumococcal histidine triad protein B 959600 7683324 SP70585_1043 Streptococcus pneumoniae 70585 pneumococcal histidine triad protein B YP_002740306.1 957039 D 488221 CDS YP_002740307.1 225858797 7683288 959810..962929 1 NC_012468.1 identified by match to protein family HMM PF04270; match to protein family HMM TIGR01363; pneumococcal histidine triad protein E 962929 7683288 SP70585_1044 Streptococcus pneumoniae 70585 pneumococcal histidine triad protein E YP_002740307.1 959810 D 488221 CDS YP_002740308.1 225858798 7685072 963759..964328 1 NC_012468.1 identified by match to protein family HMM PF04270; pneumococcal histidine triad protein E 964328 7685072 SP70585_1045 Streptococcus pneumoniae 70585 pneumococcal histidine triad protein E YP_002740308.1 963759 D 488221 CDS YP_002740309.1 225858799 7683875 964623..965252 1 NC_012468.1 hypothetical protein 965252 7683875 SP70585_1046 Streptococcus pneumoniae 70585 hypothetical protein YP_002740309.1 964623 D 488221 CDS YP_002740310.1 225858800 7683767 complement(965288..966511) 1 NC_012468.1 catalyzes the release of the N-terminal amino acid from a tripeptide; peptidase T 966511 pepT 7683767 pepT Streptococcus pneumoniae 70585 peptidase T YP_002740310.1 965288 R 488221 CDS YP_002740311.1 225858801 7684474 966665..967759 1 NC_012468.1 identified by match to protein family HMM PF00762; match to protein family HMM TIGR00109; ferrochelatase 967759 hemH 7684474 hemH Streptococcus pneumoniae 70585 ferrochelatase YP_002740311.1 966665 D 488221 CDS YP_002740312.1 225858802 7684909 complement(967801..968178) 1 NC_012468.1 identified by match to protein family HMM PF01741; match to protein family HMM TIGR00220; large conductance mechanosensitive channel protein 968178 mscL 7684909 mscL Streptococcus pneumoniae 70585 large conductance mechanosensitive channel protein YP_002740312.1 967801 R 488221 CDS YP_002740313.1 225858803 7684813 complement(968260..968691) 1 NC_012468.1 identified by match to protein family HMM PF04138; MesH protein 968691 7684813 SP70585_1050 Streptococcus pneumoniae 70585 MesH protein YP_002740313.1 968260 R 488221 CDS YP_002740314.1 225858804 7684150 968814..969323 1 NC_012468.1 identified by match to protein family HMM PF06177; citrulline cluster-linked protein 969323 7684150 SP70585_1051 Streptococcus pneumoniae 70585 citrulline cluster-linked protein YP_002740314.1 968814 D 488221 CDS YP_002740315.1 225858805 7684305 969837..970913 1 NC_012468.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 970913 asd 7684305 asd Streptococcus pneumoniae 70585 aspartate-semialdehyde dehydrogenase YP_002740315.1 969837 D 488221 CDS YP_002740316.1 225858806 7684749 970969..971904 1 NC_012468.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase 971904 dapA 7684749 dapA Streptococcus pneumoniae 70585 dihydrodipicolinate synthase YP_002740316.1 970969 D 488221 CDS YP_002740317.1 225858807 7682883 complement(971951..973324) 1 NC_012468.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE 973324 trmE 7682883 trmE Streptococcus pneumoniae 70585 tRNA modification GTPase TrmE YP_002740317.1 971951 R 488221 CDS YP_002740318.1 225858808 7683931 complement(973461..973643) 1 NC_012468.1 4-OT; member of subfamily 5; forms a dimer; the function in the Escherichia coli cell is unknown; 4-oxalocrotonate tautomerase 973643 7683931 SP70585_1056 Streptococcus pneumoniae 70585 4-oxalocrotonate tautomerase YP_002740318.1 973461 R 488221 CDS YP_002740319.1 225858809 7684520 973766..974365 1 NC_012468.1 catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 974365 tdk 7684520 tdk Streptococcus pneumoniae 70585 thymidine kinase YP_002740319.1 973766 D 488221 CDS YP_002740320.1 225858810 7684825 974355..974834 1 NC_012468.1 identified by match to protein family HMM PF00583; acetyltransferase, gnat family 974834 7684825 SP70585_1058 Streptococcus pneumoniae 70585 acetyltransferase, gnat family YP_002740320.1 974355 D 488221 CDS YP_002740321.1 225858811 7683740 974844..975923 1 NC_012468.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 975923 prfA 7683740 prfA Streptococcus pneumoniae 70585 peptide chain release factor 1 YP_002740321.1 974844 D 488221 CDS YP_002740322.1 225858812 7683986 975923..976762 1 NC_012468.1 identified by match to protein family HMM PF05175; match to protein family HMM PF08241; match to protein family HMM PF08242; match to protein family HMM TIGR00536; match to protein family HMM TIGR03387; protein-(glutamine-N5) methyltransferase, release factor-specific 976762 hemK 7683986 hemK Streptococcus pneumoniae 70585 protein-(glutamine-N5) methyltransferase, release factor-specific YP_002740322.1 975923 D 488221 CDS YP_002740323.1 225858813 7683449 976746..977348 1 NC_012468.1 identified by match to protein family HMM PF01300; match to protein family HMM TIGR00057; Sua5/YciO/YrdC/YwlC family protein 977348 7683449 SP70585_1061 Streptococcus pneumoniae 70585 Sua5/YciO/YrdC/YwlC family protein YP_002740323.1 976746 D 488221 CDS YP_002740324.1 225858814 7684900 977350..977781 1 NC_012468.1 identified by match to protein family HMM PF00583; acetyltransferase, gnat family 977781 7684900 SP70585_1062 Streptococcus pneumoniae 70585 acetyltransferase, gnat family YP_002740324.1 977350 D 488221 CDS YP_002740325.1 225858815 7684190 977843..979099 1 NC_012468.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 979099 glyA 7684190 glyA Streptococcus pneumoniae 70585 serine hydroxymethyltransferase YP_002740325.1 977843 D 488221 CDS YP_002740326.1 225858816 7684731 979107..980081 1 NC_012468.1 hypothetical protein 980081 7684731 SP70585_1064 Streptococcus pneumoniae 70585 hypothetical protein YP_002740326.1 979107 D 488221 CDS YP_002740327.1 225858817 7683054 980081..980695 1 NC_012468.1 pneumococcal vaccine antigen A 980695 7683054 SP70585_1065 Streptococcus pneumoniae 70585 pneumococcal vaccine antigen A YP_002740327.1 980081 D 488221 CDS YP_002740328.1 225858818 7684390 980769..981743 1 NC_012468.1 identified by match to protein family HMM PF06207; hypothetical protein 981743 7684390 SP70585_1066 Streptococcus pneumoniae 70585 hypothetical protein YP_002740328.1 980769 D 488221 CDS YP_002740329.1 225858819 7684566 981817..983178 1 NC_012468.1 identified by match to protein family HMM PF01938; match to protein family HMM PF05958; match to protein family HMM TIGR00479; 23S rRNA (uracil-5-)-methyltransferase RumA 983178 rumA1 7684566 rumA1 Streptococcus pneumoniae 70585 23S rRNA (uracil-5-)-methyltransferase RumA YP_002740329.1 981817 D 488221 CDS YP_002740330.1 225858820 7684964 983145..983312 1 NC_012468.1 hypothetical protein 983312 7684964 SP70585_1068 Streptococcus pneumoniae 70585 hypothetical protein YP_002740330.1 983145 D 488221 CDS YP_002740331.1 225858821 7684196 983390..983563 1 NC_012468.1 hypothetical protein 983563 7684196 SP70585_1069 Streptococcus pneumoniae 70585 hypothetical protein YP_002740331.1 983390 D 488221 CDS YP_002740332.1 225858822 7684879 983560..984369 1 NC_012468.1 identified by match to protein family HMM PF06970; replication initiator protein A (RepA) N-terminus 984369 7684879 SP70585_1070 Streptococcus pneumoniae 70585 replication initiator protein A (RepA) N-terminus YP_002740332.1 983560 D 488221 CDS YP_002740333.1 225858823 7684476 984527..985882 1 NC_012468.1 identified by match to protein family HMM PF00145; match to protein family HMM TIGR00675; methyl transferase 985882 7684476 SP70585_1071 Streptococcus pneumoniae 70585 methyl transferase YP_002740333.1 984527 D 488221 CDS YP_002740334.1 225858824 7683524 985866..986294 1 NC_012468.1 hypothetical protein 986294 7683524 SP70585_1072 Streptococcus pneumoniae 70585 hypothetical protein YP_002740334.1 985866 D 488221 CDS YP_002740335.1 225858825 7683277 986305..986688 1 NC_012468.1 arsenate reductase-like glutaredoxin family member 986688 7683277 SP70585_1073 Streptococcus pneumoniae 70585 arsenate reductase-like glutaredoxin family member YP_002740335.1 986305 D 488221 CDS YP_002740336.1 225858826 7685172 986697..986930 1 NC_012468.1 hypothetical protein 986930 7685172 SP70585_1074 Streptococcus pneumoniae 70585 hypothetical protein YP_002740336.1 986697 D 488221 CDS YP_002740337.1 225858827 7684141 987008..987517 1 NC_012468.1 identified by match to protein family HMM PF02517; protease, putative 987517 7684141 SP70585_1075 Streptococcus pneumoniae 70585 protease, putative YP_002740337.1 987008 D 488221 CDS YP_002740338.1 225858828 7683736 987558..988082 1 NC_012468.1 hypothetical protein 988082 7683736 SP70585_1076 Streptococcus pneumoniae 70585 hypothetical protein YP_002740338.1 987558 D 488221 CDS YP_002740339.1 225858829 7685007 988118..989899 1 NC_012468.1 identified by match to protein family HMM PF02534; TraG/TraD family protein 989899 7685007 SP70585_1077 Streptococcus pneumoniae 70585 TraG/TraD family protein YP_002740339.1 988118 D 488221 CDS YP_002740340.1 225858830 7683018 989917..990159 1 NC_012468.1 hypothetical protein 990159 7683018 SP70585_1078 Streptococcus pneumoniae 70585 hypothetical protein YP_002740340.1 989917 D 488221 CDS YP_002740341.1 225858831 7685182 990178..991032 1 NC_012468.1 hypothetical protein 991032 7685182 SP70585_1079 Streptococcus pneumoniae 70585 hypothetical protein YP_002740341.1 990178 D 488221 CDS YP_002740342.1 225858832 7683391 991094..991447 1 NC_012468.1 hypothetical protein 991447 7683391 SP70585_1080 Streptococcus pneumoniae 70585 hypothetical protein YP_002740342.1 991094 D 488221 CDS YP_002740343.1 225858833 7685061 993731..996532 1 NC_012468.1 identified by match to protein family HMM PF05257; CHAP domain protein 996532 7685061 SP70585_1083 Streptococcus pneumoniae 70585 CHAP domain protein YP_002740343.1 993731 D 488221 CDS YP_002740344.1 225858834 7682996 996600..997202 1 NC_012468.1 hypothetical protein 997202 7682996 SP70585_1084 Streptococcus pneumoniae 70585 hypothetical protein YP_002740344.1 996600 D 488221 CDS YP_002740345.1 225858835 7683883 997205..998179 1 NC_012468.1 identified by match to protein family HMM PF08843; hypothetical protein 998179 7683883 SP70585_1085 Streptococcus pneumoniae 70585 hypothetical protein YP_002740345.1 997205 D 488221 CDS YP_002740346.1 225858836 7685018 998197..998466 1 NC_012468.1 hypothetical protein 998466 7685018 SP70585_1086 Streptococcus pneumoniae 70585 hypothetical protein YP_002740346.1 998197 D 488221 CDS YP_002740347.1 225858837 7683781 complement(999627..1000580) 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF00665; transposase 1000580 7683781 SP70585_1087 Streptococcus pneumoniae 70585 transposase YP_002740347.1 999627 R 488221 CDS YP_002740348.1 225858838 7683352 complement(1000939..1001316) 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01609; transposase (IS4 family) 1001316 7683352 SP70585_1088 Streptococcus pneumoniae 70585 transposase (IS4 family) YP_002740348.1 1000939 R 488221 CDS YP_002740349.1 225858839 7683377 complement(1001328..1001789) 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase 1001789 7683377 SP70585_1089 Streptococcus pneumoniae 70585 transposase YP_002740349.1 1001328 R 488221 CDS YP_002740350.1 225858840 7684598 complement(1001779..1002345) 1 NC_012468.1 putative phosphatase H16_A0669 1002345 7684598 SP70585_1090 Streptococcus pneumoniae 70585 putative phosphatase H16_A0669 YP_002740350.1 1001779 R 488221 CDS YP_002740351.1 225858841 7685011 complement(1002446..1002589) 1 NC_012468.1 drug-resistant methionyl-tRNA synthetase 1002589 7685011 SP70585_1091 Streptococcus pneumoniae 70585 drug-resistant methionyl-tRNA synthetase YP_002740351.1 1002446 R 488221 CDS YP_002740352.1 225858842 7685160 1002644..1003222 1 NC_012468.1 identified by match to protein family HMM PF00302; chloramphenicol O-acetyltransferase 1003222 7685160 SP70585_1092 Streptococcus pneumoniae 70585 chloramphenicol O-acetyltransferase YP_002740352.1 1002644 D 488221 CDS YP_002740353.1 225858843 7683333 1003290..1004927 1 NC_012468.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 1004927 metG2 7683333 metG2 Streptococcus pneumoniae 70585 methionyl-tRNA synthetase YP_002740353.1 1003290 D 488221 CDS YP_002740354.1 225858844 7683250 1005028..1005594 1 NC_012468.1 putative phosphatase H16_A0669 1005594 7683250 SP70585_1094 Streptococcus pneumoniae 70585 putative phosphatase H16_A0669 YP_002740354.1 1005028 D 488221 CDS YP_002740355.1 225858845 7683583 1005584..1006045 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase 1006045 7683583 SP70585_1095 Streptococcus pneumoniae 70585 transposase YP_002740355.1 1005584 D 488221 CDS YP_002740356.1 225858846 7684078 1006057..1006434 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01609; transposase (IS4 family) 1006434 7684078 SP70585_1096 Streptococcus pneumoniae 70585 transposase (IS4 family) YP_002740356.1 1006057 D 488221 CDS YP_002740357.1 225858847 7684651 1006507..1006668 1 NC_012468.1 protein tyrosine phosphatase, putative 1006668 7684651 SP70585_1097 Streptococcus pneumoniae 70585 protein tyrosine phosphatase, putative YP_002740357.1 1006507 D 488221 CDS YP_002740358.1 225858848 7683074 1007691..1008677 1 NC_012468.1 identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1008677 7683074 SP70585_1098 Streptococcus pneumoniae 70585 ABC transporter ATP-binding protein YP_002740358.1 1007691 D 488221 CDS YP_002740359.1 225858849 7685062 1009500..1010285 1 NC_012468.1 identified by match to protein family HMM PF06182; ABC transporter permease 1010285 7685062 SP70585_1101 Streptococcus pneumoniae 70585 ABC transporter permease YP_002740359.1 1009500 D 488221 CDS YP_002740360.1 225858850 7683110 1012361..1012564 1 NC_012468.1 identified by match to protein family HMM PF01381; hypothetical protein 1012564 7683110 SP70585_1105 Streptococcus pneumoniae 70585 hypothetical protein YP_002740360.1 1012361 D 488221 CDS YP_002740361.1 225858851 7685098 1012695..1012847 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 1012847 7685098 SP70585_1106 Streptococcus pneumoniae 70585 hypothetical protein YP_002740361.1 1012695 D 488221 CDS YP_002740362.1 225858852 7683702 1014847..1015083 1 NC_012468.1 tRNA 1015083 7683702 SP70585_1109 Streptococcus pneumoniae 70585 tRNA YP_002740362.1 1014847 D 488221 CDS YP_002740363.1 225858853 7683203 1015821..1016039 1 NC_012468.1 hypothetical protein 1016039 7683203 SP70585_1110 Streptococcus pneumoniae 70585 hypothetical protein YP_002740363.1 1015821 D 488221 CDS YP_002740364.1 225858854 7683598 1016043..1016312 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 1016312 7683598 SP70585_1111 Streptococcus pneumoniae 70585 hypothetical protein YP_002740364.1 1016043 D 488221 CDS YP_002740365.1 225858855 7684808 1016433..1017458 1 NC_012468.1 identified by match to protein family HMM PF01497; ABC transporter substrate-binding protein - iron transport 1017458 7684808 SP70585_1112 Streptococcus pneumoniae 70585 ABC transporter substrate-binding protein - iron transport YP_002740365.1 1016433 D 488221 CDS YP_002740366.1 225858856 7684930 1017448..1018455 1 NC_012468.1 identified by match to protein family HMM PF01032; iron-compound ABC transporter permease 1018455 7684930 SP70585_1113 Streptococcus pneumoniae 70585 iron-compound ABC transporter permease YP_002740366.1 1017448 D 488221 CDS YP_002740367.1 225858857 7683132 1018455..1019462 1 NC_012468.1 identified by match to protein family HMM PF01032; Fe3+ ABC transporter permease 1019462 7683132 SP70585_1114 Streptococcus pneumoniae 70585 Fe3+ ABC transporter permease YP_002740367.1 1018455 D 488221 CDS YP_002740368.1 225858858 7683225 1019462..1020256 1 NC_012468.1 identified by match to protein family HMM PF00005; ferric enterobactin transport ATP-binding protein FepC 1020256 7683225 SP70585_1115 Streptococcus pneumoniae 70585 ferric enterobactin transport ATP-binding protein FepC YP_002740368.1 1019462 D 488221 CDS YP_002740369.1 225858859 7683833 1020824..1021033 1 NC_012468.1 identified by match to protein family HMM PF07674; hypothetical protein 1021033 7683833 SP70585_1116 Streptococcus pneumoniae 70585 hypothetical protein YP_002740369.1 1020824 D 488221 CDS YP_002740370.1 225858860 7684855 1021182..1021313 1 NC_012468.1 hypothetical protein 1021313 7684855 SP70585_1117 Streptococcus pneumoniae 70585 hypothetical protein YP_002740370.1 1021182 D 488221 CDS YP_002740371.1 225858861 7683684 1021997..1022158 1 NC_012468.1 hypothetical protein 1022158 7683684 SP70585_1118 Streptococcus pneumoniae 70585 hypothetical protein YP_002740371.1 1021997 D 488221 CDS YP_002740372.1 225858862 7683466 1022250..1023929 1 NC_012468.1 Low similarity to site-specific recombinase; identified by match to protein family HMM PF00239; match to protein family HMM PF07508; site-specific recombinase-like protein 1023929 7683466 SP70585_1119 Streptococcus pneumoniae 70585 site-specific recombinase-like protein YP_002740372.1 1022250 D 488221 CDS YP_002740373.1 225858863 7684946 1024197..1024763 1 NC_012468.1 hypothetical protein 1024763 7684946 SP70585_1120 Streptococcus pneumoniae 70585 hypothetical protein YP_002740373.1 1024197 D 488221 CDS YP_002740374.1 225858864 7684392 1025085..1025273 1 NC_012468.1 hypothetical protein 1025273 7684392 SP70585_1121 Streptococcus pneumoniae 70585 hypothetical protein YP_002740374.1 1025085 D 488221 CDS YP_002740375.1 225858865 7684551 1025335..1026093 1 NC_012468.1 hypothetical protein 1026093 7684551 SP70585_1122 Streptococcus pneumoniae 70585 hypothetical protein YP_002740375.1 1025335 D 488221 CDS YP_002740376.1 225858866 7684927 1026151..1027005 1 NC_012468.1 identified by match to protein family HMM PF03747; ADP-ribosylglycohydrolase superfamily 1027005 7684927 SP70585_1123 Streptococcus pneumoniae 70585 ADP-ribosylglycohydrolase superfamily YP_002740376.1 1026151 D 488221 CDS YP_002740377.1 225858867 7684796 1027117..1028001 1 NC_012468.1 identified by match to protein family HMM PF00781; match to protein family HMM TIGR00147; hypothetical protein 1028001 7684796 SP70585_1124 Streptococcus pneumoniae 70585 hypothetical protein YP_002740377.1 1027117 D 488221 CDS YP_002740378.1 225858868 7684187 1028305..1029903 1 NC_012468.1 identified by match to protein family HMM PF00128; match to protein family HMM PF02903; neopullulanase 1029903 7684187 SP70585_1125 Streptococcus pneumoniae 70585 neopullulanase YP_002740378.1 1028305 D 488221 CDS YP_002740379.1 225858869 7682989 1030178..1030633 1 NC_012468.1 hypothetical protein 1030633 7682989 SP70585_1126 Streptococcus pneumoniae 70585 hypothetical protein YP_002740379.1 1030178 D 488221 CDS YP_002740380.1 225858870 7684553 1030773..1030886 1 NC_012468.1 hypothetical protein 1030886 7684553 SP70585_1127 Streptococcus pneumoniae 70585 hypothetical protein YP_002740380.1 1030773 D 488221 CDS YP_002740381.1 225858871 7684377 1031078..1031554 1 NC_012468.1 identified by match to protein family HMM PF01381; helix-turn-helix domain protein 1031554 7684377 SP70585_1128 Streptococcus pneumoniae 70585 helix-turn-helix domain protein YP_002740381.1 1031078 D 488221 CDS YP_002740382.1 225858872 7683321 1031554..1032315 1 NC_012468.1 identified by match to protein family HMM PF06414; signal recognition particle GTPase 1032315 7683321 SP70585_1129 Streptococcus pneumoniae 70585 signal recognition particle GTPase YP_002740382.1 1031554 D 488221 CDS YP_002740383.1 225858873 7683829 1032343..1033500 1 NC_012468.1 hypothetical protein 1033500 7683829 SP70585_1130 Streptococcus pneumoniae 70585 hypothetical protein YP_002740383.1 1032343 D 488221 CDS YP_002740384.1 225858874 7684945 1034332..1034691 1 NC_012468.1 hypothetical protein 1034691 7684945 SP70585_1131 Streptococcus pneumoniae 70585 hypothetical protein YP_002740384.1 1034332 D 488221 CDS YP_002740385.1 225858875 7685038 1034701..1035066 1 NC_012468.1 identified by match to protein family HMM PF05713; putative mobilization protein MobC 1035066 7685038 SP70585_1132 Streptococcus pneumoniae 70585 putative mobilization protein MobC YP_002740385.1 1034701 D 488221 CDS YP_002740386.1 225858876 7685074 1037153..1038118 1 NC_012468.1 identified by match to protein family HMM PF01820; match to protein family HMM PF07478; match to protein family HMM TIGR01205; D-alanine--D-alanine ligase B (D-alanylalanine synthetaseB) (D-Ala-D-Ala ligase B) 1038118 7685074 SP70585_1137 Streptococcus pneumoniae 70585 D-alanine--D-alanine ligase B (D-alanylalanine synthetaseB) (D-Ala-D-Ala ligase B) YP_002740386.1 1037153 D 488221 CDS YP_002740387.1 225858877 7683969 1038517..1038645 1 NC_012468.1 transposase 1038645 7683969 SP70585_1138 Streptococcus pneumoniae 70585 transposase YP_002740387.1 1038517 D 488221 CDS YP_002740388.1 225858878 7683573 1038902..1039330 1 NC_012468.1 identified by match to protein family HMM PF00583; aminoglycoside 6'-N-acetyltransferase 1039330 7683573 SP70585_1139 Streptococcus pneumoniae 70585 aminoglycoside 6'-N-acetyltransferase YP_002740388.1 1038902 D 488221 CDS YP_002740389.1 225858879 7684108 1039388..1039996 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 1039996 7684108 SP70585_1140 Streptococcus pneumoniae 70585 hypothetical protein YP_002740389.1 1039388 D 488221 CDS YP_002740390.1 225858880 7685028 1041087..1042316 1 NC_012468.1 identified by match to protein family HMM PF01098; cell division protein FtsW 1042316 7685028 SP70585_1141 Streptococcus pneumoniae 70585 cell division protein FtsW YP_002740390.1 1041087 D 488221 CDS YP_002740391.1 225858881 7684747 1042336..1045032 1 NC_012468.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase 1045032 ppc 7684747 ppc Streptococcus pneumoniae 70585 phosphoenolpyruvate carboxylase YP_002740391.1 1042336 D 488221 CDS YP_002740392.1 225858882 7683992 1045445..1046449 1 NC_012468.1 identified by match to protein family HMM PF04392; ABC transporter substrate-binding protein 1046449 7683992 SP70585_1143 Streptococcus pneumoniae 70585 ABC transporter substrate-binding protein YP_002740392.1 1045445 D 488221 CDS YP_002740393.1 225858883 7684627 1046518..1047384 1 NC_012468.1 identified by match to protein family HMM PF02653; ABC transporter 1047384 7684627 SP70585_1144 Streptococcus pneumoniae 70585 ABC transporter YP_002740393.1 1046518 D 488221 CDS YP_002740394.1 225858884 7682914 1047381..1048139 1 NC_012468.1 identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1048139 7682914 SP70585_1145 Streptococcus pneumoniae 70585 ABC transporter ATP-binding protein YP_002740394.1 1047381 D 488221 CDS YP_002740395.1 225858885 7683289 1048229..1049989 1 NC_012468.1 synthesizes RNA primers at the replication forks; DNA primase 1049989 dnaG 7683289 dnaG Streptococcus pneumoniae 70585 DNA primase YP_002740395.1 1048229 D 488221 CDS YP_002740396.1 225858886 7684027 1049992..1051101 1 NC_012468.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; primary sigma factor of bacterium; RNA polymerase sigma factor RpoD 1051101 7684027 SP70585_1147 Streptococcus pneumoniae 70585 RNA polymerase sigma factor RpoD YP_002740396.1 1049992 D 488221 CDS YP_002740397.1 225858887 7683677 1051115..1051444 1 NC_012468.1 identified by match to protein family HMM PF01883; N-6 Adenine-specific DNA methylase YitW 1051444 7683677 SP70585_1148 Streptococcus pneumoniae 70585 N-6 Adenine-specific DNA methylase YitW YP_002740397.1 1051115 D 488221 CDS YP_002740398.1 225858888 7683008 1051559..1052602 1 NC_012468.1 identified by match to protein family HMM PF00534; glycosyl transferase CpoA 1052602 7683008 SP70585_1149 Streptococcus pneumoniae 70585 glycosyl transferase CpoA YP_002740398.1 1051559 D 488221 CDS YP_002740399.1 225858889 7684842 1052618..1053943 1 NC_012468.1 identified by match to protein family HMM PF00534; glycosyl transferase, group 1 1053943 7684842 SP70585_1150 Streptococcus pneumoniae 70585 glycosyl transferase, group 1 YP_002740399.1 1052618 D 488221 CDS YP_002740400.1 225858890 7683550 1053974..1054150 1 NC_012468.1 identified by match to protein family HMM PF04024; hypothetical protein 1054150 7683550 SP70585_1151 Streptococcus pneumoniae 70585 hypothetical protein YP_002740400.1 1053974 D 488221 CDS YP_002740401.1 225858891 7683876 1054209..1054343 1 NC_012468.1 hypothetical protein 1054343 7683876 SP70585_1152 Streptococcus pneumoniae 70585 hypothetical protein YP_002740401.1 1054209 D 488221 CDS YP_002740402.1 225858892 7684805 1054413..1055717 1 NC_012468.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 1055717 obgE 7684805 obgE Streptococcus pneumoniae 70585 GTPase ObgE YP_002740402.1 1054413 D 488221 CDS YP_002740403.1 225858893 7685129 1055727..1055885 1 NC_012468.1 hypothetical protein 1055885 7685129 SP70585_1154 Streptococcus pneumoniae 70585 hypothetical protein YP_002740403.1 1055727 D 488221 CDS YP_002740404.1 225858894 7683067 1056972..1058231 1 NC_012468.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1058231 murA1 7683067 murA1 Streptococcus pneumoniae 70585 UDP-N-acetylglucosamine 1-carboxyvinyltransferase YP_002740404.1 1056972 D 488221 CDS YP_002740405.1 225858895 7684348 1058247..1058798 1 NC_012468.1 identified by match to protein family HMM PF00583; acetyltransferase, gnat family protein 1058798 7684348 SP70585_1156 Streptococcus pneumoniae 70585 acetyltransferase, gnat family protein YP_002740405.1 1058247 D 488221 CDS YP_002740406.1 225858896 7684836 1058791..1060068 1 NC_012468.1 identified by match to protein family HMM PF00571; match to protein family HMM PF07085; match to protein family HMM PF08279; cytosolic protein containing multiple CBS domains 1060068 7684836 SP70585_1157 Streptococcus pneumoniae 70585 cytosolic protein containing multiple CBS domains YP_002740406.1 1058791 D 488221 CDS YP_002740407.1 225858897 7685134 1060084..1060944 1 NC_012468.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; methionine aminopeptidase 1060944 map 7685134 map Streptococcus pneumoniae 70585 methionine aminopeptidase YP_002740407.1 1060084 D 488221 CDS YP_002740408.1 225858898 7683163 1061324..1061548 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; mobile genetic element 1061548 7683163 SP70585_1159 Streptococcus pneumoniae 70585 mobile genetic element YP_002740408.1 1061324 D 488221 CDS YP_002740409.1 225858899 7682960 1061659..1062048 1 NC_012468.1 identified by match to protein family HMM PF01609; transposase (IS4 family) 1062048 7682960 SP70585_1160 Streptococcus pneumoniae 70585 transposase (IS4 family) YP_002740409.1 1061659 D 488221 CDS YP_002740410.1 225858900 7683856 1062231..1064522 1 NC_012468.1 identified by match to protein family HMM PF00580; match to protein family HMM TIGR01073; ATP-dependent DNA helicase PcrA 1064522 pcrA 7683856 pcrA Streptococcus pneumoniae 70585 ATP-dependent DNA helicase PcrA YP_002740410.1 1062231 D 488221 CDS YP_002740411.1 225858901 7685029 1064565..1065245 1 NC_012468.1 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase; DNA repair protein RadC 1065245 radC 7685029 radC Streptococcus pneumoniae 70585 DNA repair protein RadC YP_002740411.1 1064565 D 488221 CDS YP_002740412.1 225858902 7683580 complement(1065242..1065931) 1 NC_012468.1 identified by match to protein family HMM PF00117; match to protein family HMM PF07722; glutamine amidotransferase, class I 1065931 7683580 SP70585_1162 Streptococcus pneumoniae 70585 glutamine amidotransferase, class I YP_002740412.1 1065242 R 488221 CDS YP_002740413.1 225858903 7683171 complement(1065949..1066590) 1 NC_012468.1 modulates transcription in response to the NADH/NAD(+) redox state; redox-sensing transcriptional repressor Rex 1066590 7683171 SP70585_1164 Streptococcus pneumoniae 70585 redox-sensing transcriptional repressor Rex YP_002740413.1 1065949 R 488221 CDS YP_002740414.1 225858904 7683850 complement(1066673..1066816) 1 NC_012468.1 hypothetical protein 1066816 7683850 SP70585_1165 Streptococcus pneumoniae 70585 hypothetical protein YP_002740414.1 1066673 R 488221 CDS YP_002740415.1 225858905 7683317 complement(1066896..1067243) 1 NC_012468.1 identified by match to protein family HMM PF08866; hypothetical protein 1067243 7683317 SP70585_1166 Streptococcus pneumoniae 70585 hypothetical protein YP_002740415.1 1066896 R 488221 CDS YP_002740416.1 225858906 7682931 complement(1067248..1068363) 1 NC_012468.1 identified by match to protein family HMM PF00266; putative cysteine desulfurase (NifS protein homolog) 1068363 7682931 SP70585_1167 Streptococcus pneumoniae 70585 putative cysteine desulfurase (NifS protein homolog) YP_002740416.1 1067248 R 488221 CDS YP_002740417.1 225858907 7684414 complement(1068373..1069332) 1 NC_012468.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 1069332 7684414 SP70585_1168 Streptococcus pneumoniae 70585 ribose-phosphate pyrophosphokinase YP_002740417.1 1068373 R 488221 CDS YP_002740418.1 225858908 7683118 complement(1069442..1070011) 1 NC_012468.1 identified by match to protein family HMM PF01928; adenylate cyclase 1070011 7683118 SP70585_1169 Streptococcus pneumoniae 70585 adenylate cyclase YP_002740418.1 1069442 R 488221 CDS YP_002740419.1 225858909 7684827 1070139..1070810 1 NC_012468.1 identified by match to protein family HMM PF04607; GTP pyrophosphokinase 1070810 7684827 SP70585_1170 Streptococcus pneumoniae 70585 GTP pyrophosphokinase YP_002740419.1 1070139 D 488221 CDS YP_002740420.1 225858910 7683555 1070794..1071612 1 NC_012468.1 catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 1071612 ppnK 7683555 ppnK Streptococcus pneumoniae 70585 inorganic polyphosphate/ATP-NAD kinase YP_002740420.1 1070794 D 488221 CDS YP_002740421.1 225858911 7684708 1071609..1072505 1 NC_012468.1 identified by match to protein family HMM PF00849; match to protein family HMM TIGR00005; ribosomal large subunit pseudouridine synthase, RluD subfamily 1072505 7684708 SP70585_1172 Streptococcus pneumoniae 70585 ribosomal large subunit pseudouridine synthase, RluD subfamily YP_002740421.1 1071609 D 488221 CDS YP_002740422.1 225858912 7685108 1072549..1073523 1 NC_012468.1 in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta; phosphotransacetylase 1073523 eutD 7685108 eutD Streptococcus pneumoniae 70585 phosphotransacetylase YP_002740422.1 1072549 D 488221 CDS YP_002740423.1 225858913 7683190 complement(1073864..1074163) 1 NC_012468.1 identified by match to protein family HMM PF02575; match to protein family HMM TIGR00103; hypothetical protein 1074163 7683190 SP70585_1174 Streptococcus pneumoniae 70585 hypothetical protein YP_002740423.1 1073864 R 488221 CDS YP_002740424.1 225858914 7683372 1074565..1075263 1 NC_012468.1 identified by match to protein family HMM PF06912; hypothetical protein 1075263 7683372 SP70585_1175 Streptococcus pneumoniae 70585 hypothetical protein YP_002740424.1 1074565 D 488221 CDS YP_002740425.1 225858915 7683063 1075451..1075765 1 NC_012468.1 identified by match to protein family HMM PF00829; match to protein family HMM TIGR00061; 50S ribosomal protein L21 1075765 rplU 7683063 rplU Streptococcus pneumoniae 70585 50S ribosomal protein L21 YP_002740425.1 1075451 D 488221 CDS YP_002740426.1 225858916 7684264 1075781..1076125 1 NC_012468.1 identified by match to protein family HMM PF04327; hypothetical protein 1076125 7684264 SP70585_1177 Streptococcus pneumoniae 70585 hypothetical protein YP_002740426.1 1075781 D 488221 CDS YP_002740427.1 225858917 7684335 1076142..1076435 1 NC_012468.1 involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 1076435 rpmA 7684335 rpmA Streptococcus pneumoniae 70585 50S ribosomal protein L27 YP_002740427.1 1076142 D 488221 CDS YP_002740428.1 225858918 7684850 complement(1076675..1076845) 1 NC_012468.1 hypothetical protein 1076845 7684850 SP70585_1179 Streptococcus pneumoniae 70585 hypothetical protein YP_002740428.1 1076675 R 488221 CDS YP_002740429.1 225858919 7683104 complement(1076817..1076945) 1 NC_012468.1 hypothetical protein 1076945 7683104 SP70585_1180 Streptococcus pneumoniae 70585 hypothetical protein YP_002740429.1 1076817 R 488221 CDS YP_002740430.1 225858920 7683371 1077283..1078200 1 NC_012468.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 1078200 ribF 7683371 ribF Streptococcus pneumoniae 70585 bifunctional riboflavin kinase/FMN adenylyltransferase YP_002740430.1 1077283 D 488221 CDS YP_002740431.1 225858921 7684191 complement(1078293..1079141) 1 NC_012468.1 identified by match to protein family HMM PF02588; hypothetical protein 1079141 7684191 SP70585_1182 Streptococcus pneumoniae 70585 hypothetical protein YP_002740431.1 1078293 R 488221 CDS YP_002740432.1 225858922 7683656 1079283..1080122 1 NC_012468.1 identified by match to protein family HMM PF02645; match to protein family HMM TIGR00762; hypothetical protein 1080122 7683656 SP70585_1183 Streptococcus pneumoniae 70585 hypothetical protein YP_002740432.1 1079283 D 488221 CDS YP_002740433.1 225858923 7683343 1080229..1080504 1 NC_012468.1 identified by match to protein family HMM PF00216; DNA-binding protein HU 1 (DNA-binding protein II) (HB) 1080504 7683343 SP70585_1184 Streptococcus pneumoniae 70585 DNA-binding protein HU 1 (DNA-binding protein II) (HB) YP_002740433.1 1080229 D 488221 CDS YP_002740434.1 225858924 7684359 1080930..1082831 1 NC_012468.1 identified by match to protein family HMM PF00005; ATPase component of ABC transporter with duplicated ATPase domains 1082831 7684359 SP70585_1185 Streptococcus pneumoniae 70585 ATPase component of ABC transporter with duplicated ATPase domains YP_002740434.1 1080930 D 488221 CDS YP_002740435.1 225858925 7683958 1082834..1083697 1 NC_012468.1 identified by match to protein family HMM TIGR01716; transcriptional regulator 1083697 7683958 SP70585_1186 Streptococcus pneumoniae 70585 transcriptional regulator YP_002740435.1 1082834 D 488221 CDS YP_002740436.1 225858926 7683247 1083777..1084955 1 NC_012468.1 identified by match to protein family HMM PF07690; macrolide ABC transporter permease 1084955 7683247 SP70585_1187 Streptococcus pneumoniae 70585 macrolide ABC transporter permease YP_002740436.1 1083777 D 488221 CDS YP_002740437.1 225858927 7684799 1085048..1087006 1 NC_012468.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA 1087006 ligA 7684799 ligA Streptococcus pneumoniae 70585 NAD-dependent DNA ligase LigA YP_002740437.1 1085048 D 488221 CDS YP_002740438.1 225858928 7683080 1087118..1089397 1 NC_012468.1 identified by match to protein family HMM PF00128; match to protein family HMM PF02922; match to protein family HMM TIGR02104; pullulanase, type I 1089397 pulA 7683080 pulA Streptococcus pneumoniae 70585 pullulanase, type I YP_002740438.1 1087118 D 488221 CDS YP_002740439.1 225858929 7684071 1089942..1091366 1 NC_012468.1 identified by match to protein family HMM PF00171; NADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1091366 7684071 SP70585_1190 Streptococcus pneumoniae 70585 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase YP_002740439.1 1089942 D 488221 CDS YP_002740440.1 225858930 7683733 1091828..1093756 1 NC_012468.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching enzyme 1093756 glgB 7683733 glgB Streptococcus pneumoniae 70585 glycogen branching enzyme YP_002740440.1 1091828 D 488221 CDS YP_002740441.1 225858931 7685032 1093746..1094888 1 NC_012468.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 1094888 glgC 7685032 glgC Streptococcus pneumoniae 70585 glucose-1-phosphate adenylyltransferase YP_002740441.1 1093746 D 488221 CDS YP_002740442.1 225858932 7684101 1094878..1096017 1 NC_012468.1 identified by match to protein family HMM PF00483; match to protein family HMM TIGR02092; glucose-1-phosphate adenylyltransferase, GlgD subunit 1096017 glgD 7684101 glgD Streptococcus pneumoniae 70585 glucose-1-phosphate adenylyltransferase, GlgD subunit YP_002740442.1 1094878 D 488221 CDS YP_002740443.1 225858933 7682990 1096014..1097447 1 NC_012468.1 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose; glycogen synthase 1097447 glgA 7682990 glgA Streptococcus pneumoniae 70585 glycogen synthase YP_002740443.1 1096014 D 488221 CDS YP_002740444.1 225858934 7685126 1098160..1099275 1 NC_012468.1 identified by match to protein family HMM PF02595; match to protein family HMM TIGR00045; glycerate kinase 1099275 7685126 SP70585_1198 Streptococcus pneumoniae 70585 glycerate kinase YP_002740444.1 1098160 D 488221 CDS YP_002740445.1 225858935 7685082 complement(1099272..1099718) 1 NC_012468.1 identified by match to protein family HMM PF07997; hypothetical protein 1099718 7685082 SP70585_1197 Streptococcus pneumoniae 70585 hypothetical protein YP_002740445.1 1099272 R 488221 CDS YP_002740446.1 225858936 7684779 1099882..1101186 1 NC_012468.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 1101186 eno 7684779 eno Streptococcus pneumoniae 70585 phosphopyruvate hydratase YP_002740446.1 1099882 D 488221 CDS YP_002740447.1 225858937 7683442 1101218..1101343 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 1101343 7683442 SP70585_1200 Streptococcus pneumoniae 70585 hypothetical protein YP_002740447.1 1101218 D 488221 CDS YP_002740448.1 225858938 7683564 complement(1102258..1102611) 1 NC_012468.1 identified by match to protein family HMM PF01710; transposase 1102611 7683564 SP70585_1203 Streptococcus pneumoniae 70585 transposase YP_002740448.1 1102258 R 488221 CDS YP_002740449.1 225858939 7684773 1103137..1106412 1 NC_012468.1 identified by match to protein family HMM TIGR02774; ATP-dependent nuclease subunit B 1106412 rexB 7684773 rexB Streptococcus pneumoniae 70585 ATP-dependent nuclease subunit B YP_002740449.1 1103137 D 488221 CDS YP_002740450.1 225858940 7684975 1106409..1110059 1 NC_012468.1 identified by match to protein family HMM PF00580; match to protein family HMM TIGR02785; recombination helicase AddA 1110059 addA 7684975 addA Streptococcus pneumoniae 70585 recombination helicase AddA YP_002740450.1 1106409 D 488221 CDS YP_002740451.1 225858941 7683187 1110229..1111407 1 NC_012468.1 hypothetical protein 1111407 7683187 SP70585_1206 Streptococcus pneumoniae 70585 hypothetical protein YP_002740451.1 1110229 D 488221 CDS YP_002740452.1 225858942 7684104 1111616..1117447 1 NC_012468.1 identified by match to protein family HMM PF00746; match to protein family HMM PF04650; match to protein family HMM PF05342; match to protein family HMM PF07501; match to protein family HMM PF07580; match to protein family HMM PF07581; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; immunoglobulin A1 protease 1117447 7684104 SP70585_1207 Streptococcus pneumoniae 70585 immunoglobulin A1 protease YP_002740452.1 1111616 D 488221 CDS YP_002740453.1 225858943 7682982 1117895..1118746 1 NC_012468.1 essential GTPase; functions in ribosome assembly; binds a unique part of the 23S rRNA; interacts with ribosomal protein L25(Ctc); ribosomal biogenesis GTPase 1118746 rbgA 7682982 rbgA Streptococcus pneumoniae 70585 ribosomal biogenesis GTPase YP_002740453.1 1117895 D 488221 CDS YP_002740454.1 225858944 7683805 1118733..1119512 1 NC_012468.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 1119512 rnhB 7683805 rnhB Streptococcus pneumoniae 70585 ribonuclease HII YP_002740454.1 1118733 D 488221 CDS YP_002740455.1 225858945 7684061 1119528..1121078 1 NC_012468.1 identified by match to protein family HMM PF00654; match to protein family HMM PF02080; voltage-gated chloride channel family protein 1121078 7684061 SP70585_1210 Streptococcus pneumoniae 70585 voltage-gated chloride channel family protein YP_002740455.1 1119528 D 488221 CDS YP_002740456.1 225858946 7683540 1121664..1122734 1 NC_012468.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerS; site-specific tyrosine recombinase XerS 1122734 xerS 7683540 xerS Streptococcus pneumoniae 70585 site-specific tyrosine recombinase XerS YP_002740456.1 1121664 D 488221 CDS YP_002740457.1 225858947 7684188 complement(1122807..1123796) 1 NC_012468.1 identified by match to protein family HMM PF03099; match to protein family HMM TIGR00545; lipoate protein ligase A 1123796 7684188 SP70585_1212 Streptococcus pneumoniae 70585 lipoate protein ligase A YP_002740457.1 1122807 R 488221 CDS YP_002740458.1 225858948 7684274 complement(1123860..1125563) 1 NC_012468.1 identified by match to protein family HMM PF00070; match to protein family HMM PF00364; match to protein family HMM PF01134; match to protein family HMM PF02852; match to protein family HMM PF03486; match to protein family HMM PF07992; match to protein family HMM TIGR01350; dihydrolipoyl dehydrogenase 1125563 lpdA 7684274 lpdA Streptococcus pneumoniae 70585 dihydrolipoyl dehydrogenase YP_002740458.1 1123860 R 488221 CDS YP_002740459.1 225858949 7684477 complement(1125609..1126652) 1 NC_012468.1 unlike PdhC proteins from other organisms, some Mycoplasma lack an N-terminal lipoyl domain; in Mycoplasma hyopneumonia the PdhD proteins contains the lipoyl domain; dihydrolipoamide acetyltransferase 1126652 7684477 SP70585_1214 Streptococcus pneumoniae 70585 dihydrolipoamide acetyltransferase YP_002740459.1 1125609 R 488221 CDS YP_002740460.1 225858950 7683376 complement(1126870..1127862) 1 NC_012468.1 identified by match to protein family HMM PF02779; match to protein family HMM PF02780; pyruvate dehydrogenase E1 component subunit beta 1127862 7683376 SP70585_1215 Streptococcus pneumoniae 70585 pyruvate dehydrogenase E1 component subunit beta YP_002740460.1 1126870 R 488221 CDS YP_002740461.1 225858951 7684593 complement(1127878..1128846) 1 NC_012468.1 identified by match to protein family HMM PF00676; pyruvate dehydrogenase E1 component subunit alpha 1128846 7684593 SP70585_1216 Streptococcus pneumoniae 70585 pyruvate dehydrogenase E1 component subunit alpha YP_002740461.1 1127878 R 488221 CDS YP_002740462.1 225858952 7685023 complement(1129000..1130361) 1 NC_012468.1 identified by match to protein family HMM PF01554; match to protein family HMM TIGR00797; mate efflux family protein 1130361 7685023 SP70585_1217 Streptococcus pneumoniae 70585 mate efflux family protein YP_002740462.1 1129000 R 488221 CDS YP_002740463.1 225858953 7684201 complement(1130646..1131914) 1 NC_012468.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase 1131914 pyrC 7684201 pyrC Streptococcus pneumoniae 70585 dihydroorotase YP_002740463.1 1130646 R 488221 CDS YP_002740464.1 225858954 7683181 complement(1131927..1132391) 1 NC_012468.1 identified by match to protein family HMM PF00293; mutator MutT protein (7,8-dihydro-8-oxoguanine-triphosphatase) (8-oxo-dGTPase) (dGTP pyrophosphohydrolase) 1132391 7683181 SP70585_1219 Streptococcus pneumoniae 70585 mutator MutT protein (7,8-dihydro-8-oxoguanine-triphosphatase) (8-oxo-dGTPase) (dGTP pyrophosphohydrolase) YP_002740464.1 1131927 R 488221 CDS YP_002740465.1 225858955 7684679 complement(1132401..1133069) 1 NC_012468.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 1133069 ung 7684679 ung Streptococcus pneumoniae 70585 uracil-DNA glycosylase YP_002740465.1 1132401 R 488221 CDS YP_002740466.1 225858956 7683130 complement(1133192..1133515) 1 NC_012468.1 hypothetical protein 1133515 7683130 SP70585_1221 Streptococcus pneumoniae 70585 hypothetical protein YP_002740466.1 1133192 R 488221 CDS YP_002740467.1 225858957 7683297 complement(1133828..1134541) 1 NC_012468.1 identified by match to protein family HMM PF00702; match to protein family HMM TIGR01549; match to protein family HMM TIGR02254; HAD superfamily (subfamily IA) hydrolase 1134541 7683297 SP70585_1222 Streptococcus pneumoniae 70585 HAD superfamily (subfamily IA) hydrolase YP_002740467.1 1133828 R 488221 CDS YP_002740468.1 225858958 7684628 complement(1134602..1135540) 1 NC_012468.1 identified by match to protein family HMM PF08867; FRG domain family 1135540 7684628 SP70585_1223 Streptococcus pneumoniae 70585 FRG domain family YP_002740468.1 1134602 R 488221 CDS YP_002740469.1 225858959 7683971 complement(1135705..1135917) 1 NC_012468.1 mobile genetic element 1135917 7683971 SP70585_1224 Streptococcus pneumoniae 70585 mobile genetic element YP_002740469.1 1135705 R 488221 CDS YP_002740470.1 225858960 7684171 complement(1135993..1136367) 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 1136367 7684171 SP70585_1225 Streptococcus pneumoniae 70585 hypothetical protein YP_002740470.1 1135993 R 488221 CDS YP_002740471.1 225858961 7684052 complement(1136510..1139032) 1 NC_012468.1 identified by match to protein family HMM PF04270; match to protein family HMM TIGR01363; pneumococcal histidine triad protein B 1139032 7684052 SP70585_1226 Streptococcus pneumoniae 70585 pneumococcal histidine triad protein B YP_002740471.1 1136510 R 488221 CDS YP_002740472.1 225858962 7682977 complement(1139190..1141643) 1 NC_012468.1 identified by match to protein family HMM PF04270; match to protein family HMM TIGR01363; pneumococcal histidine triad protein B 1141643 7682977 SP70585_1227 Streptococcus pneumoniae 70585 pneumococcal histidine triad protein B YP_002740472.1 1139190 R 488221 CDS YP_002740473.1 225858963 7684913 1141764..1141901 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 1141901 7684913 SP70585_1229 Streptococcus pneumoniae 70585 hypothetical protein YP_002740473.1 1141764 D 488221 CDS YP_002740474.1 225858964 7683585 complement(1141898..1143631) 1 NC_012468.1 identified by match to protein family HMM PF00391; match to protein family HMM PF02896; match to protein family HMM PF05524; match to protein family HMM TIGR01417; phosphoenolpyruvate-protein phosphotransferase 1143631 ptsP 7683585 ptsP Streptococcus pneumoniae 70585 phosphoenolpyruvate-protein phosphotransferase YP_002740474.1 1141898 R 488221 CDS YP_002740475.1 225858965 7683827 complement(1143637..1143900) 1 NC_012468.1 identified by match to protein family HMM PF00381; match to protein family HMM TIGR01003; phosphocarrier protein HPr 1143900 7683827 SP70585_1230 Streptococcus pneumoniae 70585 phosphocarrier protein HPr YP_002740475.1 1143637 R 488221 CDS YP_002740476.1 225858966 7684402 1144251..1144469 1 NC_012468.1 identified by match to protein family HMM PF00462; match to protein family HMM TIGR02194; glutaredoxin 1144469 7684402 SP70585_1231 Streptococcus pneumoniae 70585 glutaredoxin YP_002740476.1 1144251 D 488221 CDS YP_002740477.1 225858967 7683346 1144550..1146709 1 NC_012468.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 1146709 7683346 SP70585_1232 Streptococcus pneumoniae 70585 ribonucleotide-diphosphate reductase subunit alpha YP_002740477.1 1144550 D 488221 CDS YP_002740478.1 225858968 7684585 1146897..1147859 1 NC_012468.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 1147859 nrdF 7684585 nrdF Streptococcus pneumoniae 70585 ribonucleotide-diphosphate reductase subunit beta YP_002740478.1 1146897 D 488221 CDS YP_002740479.1 225858969 7684415 1148041..1148802 1 NC_012468.1 identified by match to protein family HMM PF00455; match to protein family HMM PF08220; match to protein family HMM PF08279; lactose phosphotransferase system repressor 1148802 7684415 SP70585_1234 Streptococcus pneumoniae 70585 lactose phosphotransferase system repressor YP_002740479.1 1148041 D 488221 CDS YP_002740480.1 225858970 7683178 complement(1149081..1149260) 1 NC_012468.1 hypothetical protein 1149260 7683178 SP70585_1235 Streptococcus pneumoniae 70585 hypothetical protein YP_002740480.1 1149081 R 488221 CDS YP_002740481.1 225858971 7685189 complement(1149383..1150789) 1 NC_012468.1 catalyzes the formation of 6-phospho-galactose from a 6-phospho-beta-galactoside; 6-phospho-beta-galactosidase 1150789 lacG2 7685189 lacG2 Streptococcus pneumoniae 70585 6-phospho-beta-galactosidase YP_002740481.1 1149383 R 488221 CDS YP_002740482.1 225858972 7684220 complement(1151004..1152695) 1 NC_012468.1 identified by match to protein family HMM PF02302; match to protein family HMM PF02378; match to protein family HMM TIGR00394; match to protein family HMM TIGR00410; match to protein family HMM TIGR00853; PTS system, lactose-specific IIC component 1152695 7684220 SP70585_1237 Streptococcus pneumoniae 70585 PTS system, lactose-specific IIC component YP_002740482.1 1151004 R 488221 CDS YP_002740483.1 225858973 7683062 complement(1152695..1153012) 1 NC_012468.1 identified by match to protein family HMM PF02255; match to protein family HMM TIGR00823; lactose-specific phosphotransferase enzyme iia component (pts system lactose-specific eiia component) (eiia-lac) (eiii-lac) 1153012 7683062 SP70585_1238 Streptococcus pneumoniae 70585 lactose-specific phosphotransferase enzyme iia component (pts system lactose-specific eiia component) (eiia-lac) (eiii-lac) YP_002740483.1 1152695 R 488221 CDS YP_002740484.1 225858974 7684026 complement(1153048..1153884) 1 NC_012468.1 identified by match to protein family HMM PF00874; match to protein family HMM PF03123; transcription antiterminator LacT 1153884 7684026 SP70585_1239 Streptococcus pneumoniae 70585 transcription antiterminator LacT YP_002740484.1 1153048 R 488221 CDS YP_002740485.1 225858975 7684238 complement(1154118..1155098) 1 NC_012468.1 catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in Streptococcus pyogenes there are two paralogs of tagatose-bisphosphate aldolase, encoded by lacD1 and lacD2; expression of lacD1 is highly regulated by environmental conditions while lacD2 specializes in an efficient utilization of carbohydrate sources; tagatose 1,6-diphosphate aldolase 1155098 lacD 7684238 lacD Streptococcus pneumoniae 70585 tagatose 1,6-diphosphate aldolase YP_002740485.1 1154118 R 488221 CDS YP_002740486.1 225858976 7683262 complement(1155100..1156029) 1 NC_012468.1 catalyzes the formation of tagatose 1,6-bisphosphate from tagatose 6-phosphate and ATP; tagatose-6-phosphate kinase 1156029 lacC 7683262 lacC Streptococcus pneumoniae 70585 tagatose-6-phosphate kinase YP_002740486.1 1155100 R 488221 CDS YP_002740487.1 225858977 7683690 complement(1156040..1156555) 1 NC_012468.1 catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; galactose-6-phosphate isomerase subunit LacB 1156555 lacB 7683690 lacB Streptococcus pneumoniae 70585 galactose-6-phosphate isomerase subunit LacB YP_002740487.1 1156040 R 488221 CDS YP_002740488.1 225858978 7682913 complement(1156586..1157011) 1 NC_012468.1 catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; tagatose pathway for galactose utilization; galactose-6-phosphate isomerase subunit LacA 1157011 lacA 7682913 lacA Streptococcus pneumoniae 70585 galactose-6-phosphate isomerase subunit LacA YP_002740488.1 1156586 R 488221 CDS YP_002740489.1 225858979 7685010 complement(1157168..1157512) 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 1157512 7685010 SP70585_1244 Streptococcus pneumoniae 70585 hypothetical protein YP_002740489.1 1157168 R 488221 CDS YP_002740490.1 225858980 7684699 complement(1157681..1158061) 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; mobile genetic element 1158061 7684699 SP70585_1245 Streptococcus pneumoniae 70585 mobile genetic element YP_002740490.1 1157681 R 488221 CDS YP_002740491.1 225858981 7684397 complement(1158068..1158466) 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; mobile genetic element 1158466 7684397 SP70585_1246 Streptococcus pneumoniae 70585 mobile genetic element YP_002740491.1 1158068 R 488221 CDS YP_002740492.1 225858982 7684678 complement(1158474..1158776) 1 NC_012468.1 PTS system, galactose-specific IIB component 1158776 7684678 SP70585_1247 Streptococcus pneumoniae 70585 PTS system, galactose-specific IIB component YP_002740492.1 1158474 R 488221 CDS YP_002740493.1 225858983 7683120 complement(1158814..1159203) 1 NC_012468.1 phosphotransferase system sugar-specific EII component 1159203 7683120 SP70585_1248 Streptococcus pneumoniae 70585 phosphotransferase system sugar-specific EII component YP_002740493.1 1158814 R 488221 CDS YP_002740494.1 225858984 7684608 1159470..1159802 1 NC_012468.1 chlorohydrolase 1159802 7684608 SP70585_1249 Streptococcus pneumoniae 70585 chlorohydrolase YP_002740494.1 1159470 D 488221 CDS YP_002740495.1 225858985 7682908 complement(1159883..1161706) 1 NC_012468.1 binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 1161706 lepA 7682908 lepA Streptococcus pneumoniae 70585 GTP-binding protein LepA YP_002740495.1 1159883 R 488221 CDS YP_002740496.1 225858986 7683244 complement(1161785..1162513) 1 NC_012468.1 identified by match to protein family HMM PF00149; serine/threonine protein phosphatase 1162513 7683244 SP70585_1251 Streptococcus pneumoniae 70585 serine/threonine protein phosphatase YP_002740496.1 1161785 R 488221 CDS YP_002740497.1 225858987 7683558 complement(1162515..1164182) 1 NC_012468.1 identified by match to protein family HMM PF02463; match to protein family HMM TIGR00634; DNA repair protein RecN 1164182 recN 7683558 recN Streptococcus pneumoniae 70585 DNA repair protein RecN YP_002740497.1 1162515 R 488221 CDS YP_002740498.1 225858988 7684512 complement(1164189..1164620) 1 NC_012468.1 identified by match to protein family HMM PF01316; match to protein family HMM PF02863; transcriptional regulator of arginine metabolism expression 1164620 7684512 SP70585_1253 Streptococcus pneumoniae 70585 transcriptional regulator of arginine metabolism expression YP_002740498.1 1164189 R 488221 CDS YP_002740499.1 225858989 7685094 complement(1164613..1165428) 1 NC_012468.1 identified by match to protein family HMM PF01479; match to protein family HMM PF01728; match to protein family HMM TIGR00478; hemolysin A 1165428 tylA 7685094 tylA Streptococcus pneumoniae 70585 hemolysin A YP_002740499.1 1164613 R 488221 CDS YP_002740500.1 225858990 7684167 complement(1165421..1166296) 1 NC_012468.1 identified by match to protein family HMM PF00348; geranyltranstransferase (Farnesyl-diphosphate synthase)(FPP synthase) 1166296 7684167 SP70585_1255 Streptococcus pneumoniae 70585 geranyltranstransferase (Farnesyl-diphosphate synthase)(FPP synthase) YP_002740500.1 1165421 R 488221 CDS YP_002740501.1 225858991 7684499 complement(1166293..1166505) 1 NC_012468.1 catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit 1166505 xseB 7684499 xseB Streptococcus pneumoniae 70585 exodeoxyribonuclease VII small subunit YP_002740501.1 1166293 R 488221 CDS YP_002740502.1 225858992 7684433 complement(1166483..1167823) 1 NC_012468.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 1167823 xseA 7684433 xseA Streptococcus pneumoniae 70585 exodeoxyribonuclease VII large subunit YP_002740502.1 1166483 R 488221 CDS YP_002740503.1 225858993 7682924 complement(1167951..1168589) 1 NC_012468.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase 1168589 udk 7682924 udk Streptococcus pneumoniae 70585 uridine kinase YP_002740503.1 1167951 R 488221 CDS YP_002740504.1 225858994 7683841 complement(1168697..1168999) 1 NC_012468.1 hypothetical protein 1168999 7683841 SP70585_1259 Streptococcus pneumoniae 70585 hypothetical protein YP_002740504.1 1168697 R 488221 CDS YP_002740505.1 225858995 7683483 complement(1169240..1170118) 1 NC_012468.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B 1170118 truB 7683483 truB Streptococcus pneumoniae 70585 tRNA pseudouridine synthase B YP_002740505.1 1169240 R 488221 CDS YP_002740506.1 225858996 7683207 complement(1170128..1171402) 1 NC_012468.1 hypothetical protein 1171402 7683207 SP70585_1261 Streptococcus pneumoniae 70585 hypothetical protein YP_002740506.1 1170128 R 488221 CDS YP_002740507.1 225858997 7683253 complement(1171573..1172613) 1 NC_012468.1 identified by match to protein family HMM PF01053; match to protein family HMM PF01212; O-acetylhomoserine (thiol)-lyase (O-acetylhomoserinesulfhydrylase) (OAH sulfhydrylase) (Homocysteine synthase) 1172613 7683253 SP70585_1262 Streptococcus pneumoniae 70585 O-acetylhomoserine (thiol)-lyase (O-acetylhomoserinesulfhydrylase) (OAH sulfhydrylase) (Homocysteine synthase) YP_002740507.1 1171573 R 488221 CDS YP_002740508.1 225858998 7683099 complement(1172635..1172757) 1 NC_012468.1 O-acetylhomoserine sulfhydrylase 1172757 7683099 SP70585_1263 Streptococcus pneumoniae 70585 O-acetylhomoserine sulfhydrylase YP_002740508.1 1172635 R 488221 CDS YP_002740509.1 225858999 7683826 complement(1172905..1173702) 1 NC_012468.1 identified by match to protein family HMM PF01226; formate-nitrate transporter 1173702 7683826 SP70585_1264 Streptococcus pneumoniae 70585 formate-nitrate transporter YP_002740509.1 1172905 R 488221 CDS YP_002740510.1 225859000 7685021 complement(1173946..1174689) 1 NC_012468.1 identified by match to protein family HMM PF04203; match to protein family HMM TIGR01076; sortase 1174689 7685021 SP70585_1265 Streptococcus pneumoniae 70585 sortase YP_002740510.1 1173946 R 488221 CDS YP_002740511.1 225859001 7684123 complement(1174689..1177157) 1 NC_012468.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A 1177157 gyrA 7684123 gyrA Streptococcus pneumoniae 70585 DNA gyrase subunit A YP_002740511.1 1174689 R 488221 CDS YP_002740512.1 225859002 7683501 1177351..1178337 1 NC_012468.1 Converts (S)-lactate and NAD(+) to pyruvate and NADH; L-lactate dehydrogenase 1178337 ldh 7683501 ldh Streptococcus pneumoniae 70585 L-lactate dehydrogenase YP_002740512.1 1177351 D 488221 CDS YP_002740513.1 225859003 7683373 complement(1178597..1179370) 1 NC_012468.1 identified by match to protein family HMM PF00520; match to protein family HMM PF07885; potassium/ion channel protein 1179370 7683373 SP70585_1268 Streptococcus pneumoniae 70585 potassium/ion channel protein YP_002740513.1 1178597 R 488221 CDS YP_002740514.1 225859004 7683097 complement(1179417..1179671) 1 NC_012468.1 identified by match to protein family HMM PF05016; match to protein family HMM TIGR02385; cytotoxic translational repressor of toxin-antitoxin stability system 1179671 7683097 SP70585_1269 Streptococcus pneumoniae 70585 cytotoxic translational repressor of toxin-antitoxin stability system YP_002740514.1 1179417 R 488221 CDS YP_002740515.1 225859005 7683291 complement(1179673..1179915) 1 NC_012468.1 hypothetical protein 1179915 7683291 SP70585_1270 Streptococcus pneumoniae 70585 hypothetical protein YP_002740515.1 1179673 R 488221 CDS YP_002740516.1 225859006 7682919 complement(1180006..1180815) 1 NC_012468.1 identified by match to protein family HMM PF00753; VicX protein 1180815 7682919 SP70585_1271 Streptococcus pneumoniae 70585 VicX protein YP_002740516.1 1180006 R 488221 CDS YP_002740517.1 225859007 7683471 complement(1180817..1182166) 1 NC_012468.1 identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF00989; match to protein family HMM PF02518; match to protein family HMM TIGR00229; sensor protein YycG 1182166 7683471 SP70585_1272 Streptococcus pneumoniae 70585 sensor protein YycG YP_002740517.1 1180817 R 488221 CDS YP_002740518.1 225859008 7684712 complement(1182159..1182863) 1 NC_012468.1 identified by match to protein family HMM PF00072; match to protein family HMM PF00486; alkaline phosphatase synthesis transcriptional regulatory proteinphoP 1182863 7684712 SP70585_1273 Streptococcus pneumoniae 70585 alkaline phosphatase synthesis transcriptional regulatory proteinphoP YP_002740518.1 1182159 R 488221 CDS YP_002740519.1 225859009 7685069 complement(1182918..1184093) 1 NC_012468.1 identified by match to protein family HMM PF00633; match to protein family HMM PF00730; match to protein family HMM TIGR01084; A/G-specific adenine glycosylase 1184093 mutY 7685069 mutY Streptococcus pneumoniae 70585 A/G-specific adenine glycosylase YP_002740519.1 1182918 R 488221 CDS YP_002740520.1 225859010 7683155 complement(1184421..1186091) 1 NC_012468.1 catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate; formate--tetrahydrofolate ligase 1186091 fhs 7683155 fhs Streptococcus pneumoniae 70585 formate--tetrahydrofolate ligase YP_002740520.1 1184421 R 488221 CDS YP_002740521.1 225859011 7683646 1186321..1187010 1 NC_012468.1 identified by match to protein family HMM PF04127; match to protein family HMM TIGR02114; phosphopantothenate--cysteine ligase 1187010 coaB 7683646 coaB Streptococcus pneumoniae 70585 phosphopantothenate--cysteine ligase YP_002740521.1 1186321 D 488221 CDS YP_002740522.1 225859012 7684867 1187022..1187573 1 NC_012468.1 decarboxylates 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine.; phosphopantothenoylcysteine decarboxylase 1187573 coaC 7684867 coaC Streptococcus pneumoniae 70585 phosphopantothenoylcysteine decarboxylase YP_002740522.1 1187022 D 488221 CDS YP_002740523.1 225859013 7684419 1187557..1188120 1 NC_012468.1 integral membrane protein 1188120 7684419 SP70585_1278 Streptococcus pneumoniae 70585 integral membrane protein YP_002740523.1 1187557 D 488221 CDS YP_002740524.1 225859014 7684560 1188402..1188929 1 NC_012468.1 hypothetical protein 1188929 7684560 SP70585_1279 Streptococcus pneumoniae 70585 hypothetical protein YP_002740524.1 1188402 D 488221 CDS YP_002740525.1 225859015 7683002 1188941..1189456 1 NC_012468.1 identified by match to protein family HMM PF02829; match to protein family HMM PF08279; transcriptional regulator, biotin repressor family 1189456 7683002 SP70585_1281 Streptococcus pneumoniae 70585 transcriptional regulator, biotin repressor family YP_002740525.1 1188941 D 488221 CDS YP_002740526.1 225859016 7684633 complement(1189453..1189593) 1 NC_012468.1 hypothetical protein 1189593 7684633 SP70585_1280 Streptococcus pneumoniae 70585 hypothetical protein YP_002740526.1 1189453 R 488221 CDS YP_002740527.1 225859017 7684719 1189646..1189831 1 NC_012468.1 IS66 family element 1189831 7684719 SP70585_1282 Streptococcus pneumoniae 70585 IS66 family element YP_002740527.1 1189646 D 488221 CDS YP_002740528.1 225859018 7683688 1189812..1190135 1 NC_012468.1 identified by match to protein family HMM PF05717; IS66 family element, Orf2 1190135 7683688 SP70585_1283 Streptococcus pneumoniae 70585 IS66 family element, Orf2 YP_002740528.1 1189812 D 488221 CDS YP_002740529.1 225859019 7684580 complement(1190290..1190556) 1 NC_012468.1 transposase family protein 1190556 7684580 SP70585_1284 Streptococcus pneumoniae 70585 transposase family protein YP_002740529.1 1190290 R 488221 CDS YP_002740530.1 225859020 7683172 complement(1191790..1192251) 1 NC_012468.1 transposase 1192251 7683172 SP70585_1288 Streptococcus pneumoniae 70585 transposase YP_002740530.1 1191790 R 488221 CDS YP_002740531.1 225859021 7684113 complement(1192633..1193730) 1 NC_012468.1 identified by match to protein family HMM PF00512; match to protein family HMM PF02518; NisK 1193730 7684113 SP70585_1289 Streptococcus pneumoniae 70585 NisK YP_002740531.1 1192633 R 488221 CDS YP_002740532.1 225859022 7685006 complement(1193715..1194398) 1 NC_012468.1 identified by match to protein family HMM PF00072; match to protein family HMM PF00486; NisR 1194398 7685006 SP70585_1290 Streptococcus pneumoniae 70585 NisR YP_002740532.1 1193715 R 488221 CDS YP_002740533.1 225859023 7685114 complement(1194429..1195136) 1 NC_012468.1 hypothetical protein 1195136 7685114 SP70585_1291 Streptococcus pneumoniae 70585 hypothetical protein YP_002740533.1 1194429 R 488221 CDS YP_002740534.1 225859024 7682886 complement(1195133..1195924) 1 NC_012468.1 hypothetical protein 1195924 7682886 SP70585_1292 Streptococcus pneumoniae 70585 hypothetical protein YP_002740534.1 1195133 R 488221 CDS YP_002740535.1 225859025 7684610 complement(1195914..1196630) 1 NC_012468.1 identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1196630 7684610 SP70585_1293 Streptococcus pneumoniae 70585 ABC transporter ATP-binding protein YP_002740535.1 1195914 R 488221 CDS YP_002740536.1 225859026 7684446 complement(1196643..1198865) 1 NC_012468.1 identified by match to protein family HMM PF00005; match to protein family HMM PF00664; ABC transporter NBP/MSD fusion protein 1198865 7684446 SP70585_1294 Streptococcus pneumoniae 70585 ABC transporter NBP/MSD fusion protein YP_002740536.1 1196643 R 488221 CDS YP_002740537.1 225859027 7684752 complement(1198869..1199120) 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 1199120 7684752 SP70585_1295 Streptococcus pneumoniae 70585 hypothetical protein YP_002740537.1 1198869 R 488221 CDS YP_002740538.1 225859028 7683096 complement(1199135..1200859) 1 NC_012468.1 identified by match to protein family HMM PF00733; putative asparagine synthetase 1200859 7683096 SP70585_1296 Streptococcus pneumoniae 70585 putative asparagine synthetase YP_002740538.1 1199135 R 488221 CDS YP_002740539.1 225859029 7684881 complement(1200976..1201104) 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 1201104 7684881 SP70585_1297 Streptococcus pneumoniae 70585 hypothetical protein YP_002740539.1 1200976 R 488221 CDS YP_002740540.1 225859030 7684142 complement(1201830..1202102) 1 NC_012468.1 NTP pyrophosphohydrolase including oxidative damage repair enzymes 1202102 7684142 SP70585_1298 Streptococcus pneumoniae 70585 NTP pyrophosphohydrolase including oxidative damage repair enzymes YP_002740540.1 1201830 R 488221 CDS YP_002740541.1 225859031 7683961 complement(1202347..1202856) 1 NC_012468.1 identified by match to protein family HMM PF00583; acetyltransferase, gnat family 1202856 7683961 SP70585_1299 Streptococcus pneumoniae 70585 acetyltransferase, gnat family YP_002740541.1 1202347 R 488221 CDS YP_002740542.1 225859032 7683997 complement(1202822..1203385) 1 NC_012468.1 acetyltransferase, gnat family 1203385 7683997 SP70585_1300 Streptococcus pneumoniae 70585 acetyltransferase, gnat family YP_002740542.1 1202822 R 488221 CDS YP_002740543.1 225859033 7684059 complement(1203395..1205383) 1 NC_012468.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 1205383 uvrB 7684059 uvrB Streptococcus pneumoniae 70585 excinuclease ABC subunit B YP_002740543.1 1203395 R 488221 CDS YP_002740544.1 225859034 7683044 complement(1205460..1206413) 1 NC_012468.1 identified by match to protein family HMM PF02517; caax amino protease family 1206413 7683044 SP70585_1302 Streptococcus pneumoniae 70585 caax amino protease family YP_002740544.1 1205460 R 488221 CDS YP_002740545.1 225859035 7683491 1206585..1208750 1 NC_012468.1 identified by match to protein family HMM PF00497; match to protein family HMM PF00528; match to protein family HMM TIGR01726; amino acid ABC transporter permease/substrate-binding protein 1208750 7683491 SP70585_1303 Streptococcus pneumoniae 70585 amino acid ABC transporter permease/substrate-binding protein YP_002740545.1 1206585 D 488221 CDS YP_002740546.1 225859036 7684834 1208750..1209490 1 NC_012468.1 identified by match to protein family HMM PF00005; glutamine transport ATP-binding protein GlnQ 1209490 7684834 SP70585_1304 Streptococcus pneumoniae 70585 glutamine transport ATP-binding protein GlnQ YP_002740546.1 1208750 D 488221 CDS YP_002740547.1 225859037 7682904 1209639..1211126 1 NC_012468.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 1211126 zwf 7682904 zwf Streptococcus pneumoniae 70585 glucose-6-phosphate 1-dehydrogenase YP_002740547.1 1209639 D 488221 CDS YP_002740548.1 225859038 7683426 complement(1211170..1212447) 1 NC_012468.1 identified by match to protein family HMM PF00448; match to protein family HMM PF02881; match to protein family HMM TIGR00064; cell division protein FtsY 1212447 7683426 SP70585_1306 Streptococcus pneumoniae 70585 cell division protein FtsY YP_002740548.1 1211170 R 488221 CDS YP_002740549.1 225859039 7683607 complement(1212451..1213269) 1 NC_012468.1 identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; Cof family protein 1213269 7683607 SP70585_1307 Streptococcus pneumoniae 70585 Cof family protein YP_002740549.1 1212451 R 488221 CDS YP_002740550.1 225859040 7683166 complement(1213269..1214063) 1 NC_012468.1 identified by match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; Cof family protein 1214063 7683166 SP70585_1308 Streptococcus pneumoniae 70585 Cof family protein YP_002740550.1 1213269 R 488221 CDS YP_002740551.1 225859041 7683009 complement(1214060..1217599) 1 NC_012468.1 identified by match to protein family HMM PF02463; match to protein family HMM PF06470; match to protein family HMM TIGR02168; chromosome segregation protein SMC 1217599 smc 7683009 smc Streptococcus pneumoniae 70585 chromosome segregation protein SMC YP_002740551.1 1214060 R 488221 CDS YP_002740552.1 225859042 7684959 complement(1217590..1218288) 1 NC_012468.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 1218288 rnc 7684959 rnc Streptococcus pneumoniae 70585 ribonuclease III YP_002740552.1 1217590 R 488221 CDS YP_002740553.1 225859043 7683902 complement(1218606..1219592) 1 NC_012468.1 identified by match to protein family HMM PF00478; match to protein family HMM TIGR01306; guanosine 5'-monophosphate oxidoreductase 1219592 guaC 7683902 guaC Streptococcus pneumoniae 70585 guanosine 5'-monophosphate oxidoreductase YP_002740553.1 1218606 R 488221 CDS YP_002740554.1 225859044 7683395 complement(1219767..1221083) 1 NC_012468.1 hypothetical protein 1221083 7683395 SP70585_1313 Streptococcus pneumoniae 70585 hypothetical protein YP_002740554.1 1219767 R 488221 CDS YP_002740555.1 225859045 7683749 complement(1221070..1223001) 1 NC_012468.1 hypothetical protein 1223001 7683749 SP70585_1314 Streptococcus pneumoniae 70585 hypothetical protein YP_002740555.1 1221070 R 488221 CDS YP_002740556.1 225859046 7685066 complement(1223164..1223325) 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 1223325 7685066 SP70585_1315 Streptococcus pneumoniae 70585 hypothetical protein YP_002740556.1 1223164 R 488221 CDS YP_002740557.1 225859047 7684530 complement(1223315..1223488) 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 1223488 7684530 SP70585_1316 Streptococcus pneumoniae 70585 hypothetical protein YP_002740557.1 1223315 R 488221 CDS YP_002740558.1 225859048 7683678 complement(1223588..1223731) 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 1223731 7683678 SP70585_1317 Streptococcus pneumoniae 70585 hypothetical protein YP_002740558.1 1223588 R 488221 CDS YP_002740559.1 225859049 7683584 complement(1223950..1224309) 1 NC_012468.1 hypothetical protein 1224309 7683584 SP70585_1318 Streptococcus pneumoniae 70585 hypothetical protein YP_002740559.1 1223950 R 488221 CDS YP_002740560.1 225859050 7684935 complement(1224313..1224582) 1 NC_012468.1 identified by match to protein family HMM PF06961; hypothetical protein 1224582 7684935 SP70585_1319 Streptococcus pneumoniae 70585 hypothetical protein YP_002740560.1 1224313 R 488221 CDS YP_002740561.1 225859051 7683797 complement(1224579..1225616) 1 NC_012468.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase 1225616 leuB 7683797 leuB Streptococcus pneumoniae 70585 3-isopropylmalate dehydrogenase YP_002740561.1 1224579 R 488221 CDS YP_002740562.1 225859052 7683007 complement(1225628..1226062) 1 NC_012468.1 identified by match to protein family HMM PF08502; 2-isopropylmalate synthase (Alpha-isopropylmalatesynthase) (Alpha-IPM synthetase) 1226062 7683007 SP70585_1321 Streptococcus pneumoniae 70585 2-isopropylmalate synthase (Alpha-isopropylmalatesynthase) (Alpha-IPM synthetase) YP_002740562.1 1225628 R 488221 CDS YP_002740563.1 225859053 7683673 complement(1226090..1226722) 1 NC_012468.1 identified by match to protein family HMM PF00682; 2-isopropylmalate synthase (Alpha-isopropylmalatesynthase) (Alpha-IPM synthetase) 1226722 7683673 SP70585_1322 Streptococcus pneumoniae 70585 2-isopropylmalate synthase (Alpha-isopropylmalatesynthase) (Alpha-IPM synthetase) YP_002740563.1 1226090 R 488221 CDS YP_002740564.1 225859054 7684786 complement(1226741..1227397) 1 NC_012468.1 identified by match to protein family HMM PF04237; hypothetical protein 1227397 7684786 SP70585_1323 Streptococcus pneumoniae 70585 hypothetical protein YP_002740564.1 1226741 R 488221 CDS YP_002740565.1 225859055 7683462 complement(1227441..1228073) 1 NC_012468.1 identified by match to protein family HMM PF03932; copper homeostasis protein CutC 1228073 7683462 SP70585_1324 Streptococcus pneumoniae 70585 copper homeostasis protein CutC YP_002740565.1 1227441 R 488221 CDS YP_002740566.1 225859056 7683627 complement(1228166..1228525) 1 NC_012468.1 identified by match to protein family HMM PF04304; hypothetical protein 1228525 7683627 SP70585_1325 Streptococcus pneumoniae 70585 hypothetical protein YP_002740566.1 1228166 R 488221 CDS YP_002740567.1 225859057 7684363 complement(1228631..1230718) 1 NC_012468.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I 1230718 topA 7684363 topA Streptococcus pneumoniae 70585 DNA topoisomerase I YP_002740567.1 1228631 R 488221 CDS YP_002740568.1 225859058 7683092 complement(1230885..1231928) 1 NC_012468.1 identified by match to protein family HMM PF04087; hypothetical protein 1231928 7683092 SP70585_1327 Streptococcus pneumoniae 70585 hypothetical protein YP_002740568.1 1230885 R 488221 CDS YP_002740569.1 225859059 7685166 1232506..1232628 1 NC_012468.1 chlorohydrolase 1232628 7685166 SP70585_1328 Streptococcus pneumoniae 70585 chlorohydrolase YP_002740569.1 1232506 D 488221 CDS YP_002740570.1 225859060 7683427 complement(1232812..1233660) 1 NC_012468.1 identified by match to protein family HMM PF02481; match to protein family HMM TIGR00732; DNA protecting protein DprA 1233660 dprA 7683427 dprA Streptococcus pneumoniae 70585 DNA protecting protein DprA YP_002740570.1 1232812 R 488221 CDS YP_002740571.1 225859061 7683016 complement(1233756..1234445) 1 NC_012468.1 identified by match to protein family HMM PF00483; LPS epitope expression regulatory protein 1234445 7683016 SP70585_1330 Streptococcus pneumoniae 70585 LPS epitope expression regulatory protein YP_002740571.1 1233756 R 488221 CDS YP_002740572.1 225859062 7684809 complement(1234457..1235335) 1 NC_012468.1 identified by match to protein family HMM PF00892; LPS epitope expression regulatory protein 1235335 7684809 SP70585_1331 Streptococcus pneumoniae 70585 LPS epitope expression regulatory protein YP_002740572.1 1234457 R 488221 CDS YP_002740573.1 225859063 7683880 complement(1235325..1236194) 1 NC_012468.1 identified by match to protein family HMM PF01633; match to protein family HMM PF01636; choline kinase 1236194 7683880 SP70585_1332 Streptococcus pneumoniae 70585 choline kinase YP_002740573.1 1235325 R 488221 CDS YP_002740574.1 225859064 7684872 complement(1236211..1237233) 1 NC_012468.1 identified by match to protein family HMM PF08240; xylitol dehydrogenase 1237233 7684872 SP70585_1333 Streptococcus pneumoniae 70585 xylitol dehydrogenase YP_002740574.1 1236211 R 488221 CDS YP_002740575.1 225859065 7684462 complement(1237238..1237945) 1 NC_012468.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 1237945 ispD 7684462 ispD Streptococcus pneumoniae 70585 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase YP_002740575.1 1237238 R 488221 CDS YP_002740576.1 225859066 7683506 1238281..1239768 1 NC_012468.1 identified by match to protein family HMM PF01943; match to protein family HMM PF03023; virulence factor mvin superfamily 1239768 7683506 SP70585_1335 Streptococcus pneumoniae 70585 virulence factor mvin superfamily YP_002740576.1 1238281 D 488221 CDS YP_002740577.1 225859067 7684936 1239778..1240581 1 NC_012468.1 required for phosphorylcholine incorporation in teichoic and lipoteichoic acids; identified by match to protein family HMM PF04991; phosphotransferase 1240581 7684936 SP70585_1336 Streptococcus pneumoniae 70585 phosphotransferase YP_002740577.1 1239778 D 488221 CDS YP_002740578.1 225859068 7685154 1240583..1241392 1 NC_012468.1 identified by match to protein family HMM PF04991; LicD Protein 1241392 7685154 SP70585_1337 Streptococcus pneumoniae 70585 LicD Protein YP_002740578.1 1240583 D 488221 CDS YP_002740579.1 225859069 7684237 complement(1241667..1244843) 1 NC_012468.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 1244843 carB 7684237 carB Streptococcus pneumoniae 70585 carbamoyl phosphate synthase large subunit YP_002740579.1 1241667 R 488221 CDS YP_002740580.1 225859070 7684083 complement(1245155..1246234) 1 NC_012468.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 1246234 carA 7684083 carA Streptococcus pneumoniae 70585 carbamoyl phosphate synthase small subunit YP_002740580.1 1245155 R 488221 CDS YP_002740581.1 225859071 7684493 complement(1246284..1247207) 1 NC_012468.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase catalytic subunit 1247207 pyrB 7684493 pyrB Streptococcus pneumoniae 70585 aspartate carbamoyltransferase catalytic subunit YP_002740581.1 1246284 R 488221 CDS YP_002740582.1 225859072 7683495 complement(1247226..1247747) 1 NC_012468.1 regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity; bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase 1247747 7683495 SP70585_1341 Streptococcus pneumoniae 70585 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase YP_002740582.1 1247226 R 488221 CDS YP_002740583.1 225859073 7684365 complement(1247958..1248587) 1 NC_012468.1 identified by match to protein family HMM PF00633; match to protein family HMM PF00730; match to protein family HMM TIGR01083; endonuclease III 1248587 nth 7684365 nth Streptococcus pneumoniae 70585 endonuclease III YP_002740583.1 1247958 R 488221 CDS YP_002740584.1 225859074 7682938 complement(1248587..1249129) 1 NC_012468.1 identified by match to protein family HMM PF02620; hypothetical protein 1249129 7682938 SP70585_1343 Streptococcus pneumoniae 70585 hypothetical protein YP_002740584.1 1248587 R 488221 CDS YP_002740585.1 225859075 7684589 1249299..1249616 1 NC_012468.1 BlpT protein, fusion 1249616 7684589 SP70585_1344 Streptococcus pneumoniae 70585 BlpT protein, fusion YP_002740585.1 1249299 D 488221 CDS YP_002740586.1 225859076 7684407 1249855..1251414 1 NC_012468.1 identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1251414 7684407 SP70585_1345 Streptococcus pneumoniae 70585 ABC transporter ATP-binding protein YP_002740586.1 1249855 D 488221 CDS YP_002740587.1 225859077 7684065 complement(1251451..1251978) 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase 1251978 7684065 SP70585_1346 Streptococcus pneumoniae 70585 transposase YP_002740587.1 1251451 R 488221 CDS YP_002740588.1 225859078 7684358 complement(1251975..1252757) 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01610; transposase 1252757 7684358 SP70585_1347 Streptococcus pneumoniae 70585 transposase YP_002740588.1 1251975 R 488221 CDS YP_002740589.1 225859079 7684665 complement(1253035..1253934) 1 NC_012468.1 putative metalloprotease; heat shock protein HtpX 1253934 7684665 SP70585_1348 Streptococcus pneumoniae 70585 heat shock protein HtpX YP_002740589.1 1253035 R 488221 CDS YP_002740590.1 225859080 7683691 complement(1253936..1254496) 1 NC_012468.1 identified by match to protein family HMM PF04011; cytoplasmic membrane protein 1254496 7683691 SP70585_1349 Streptococcus pneumoniae 70585 cytoplasmic membrane protein YP_002740590.1 1253936 R 488221 CDS YP_002740591.1 225859081 7684952 1254590..1255303 1 NC_012468.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 1255303 gidB 7684952 gidB Streptococcus pneumoniae 70585 16S rRNA methyltransferase GidB YP_002740591.1 1254590 D 488221 CDS YP_002740592.1 225859082 7682930 1255557..1256840 1 NC_012468.1 identified by match to protein family HMM PF00860; match to protein family HMM TIGR00801; uracil permease (Uracil transporter) 1256840 7682930 SP70585_1351 Streptococcus pneumoniae 70585 uracil permease (Uracil transporter) YP_002740592.1 1255557 D 488221 CDS YP_002740593.1 225859083 7683697 complement(1257035..1258606) 1 NC_012468.1 identified by match to protein family HMM PF00448; match to protein family HMM PF02881; match to protein family HMM PF02978; match to protein family HMM TIGR00959; signal recognition particle protein 1258606 ffh 7683697 ffh Streptococcus pneumoniae 70585 signal recognition particle protein YP_002740593.1 1257035 R 488221 CDS YP_002740594.1 225859084 7683103 complement(1258618..1258950) 1 NC_012468.1 identified by match to protein family HMM PF04297; match to protein family HMM PF04967; match to protein family HMM PF08281; putative DNA-binding protein 1258950 7683103 SP70585_1353 Streptococcus pneumoniae 70585 putative DNA-binding protein YP_002740594.1 1258618 R 488221 CDS YP_002740595.1 225859085 7683290 complement(1259040..1259417) 1 NC_012468.1 identified by match to protein family HMM PF09148; hypothetical protein 1259417 7683290 SP70585_1354 Streptococcus pneumoniae 70585 hypothetical protein YP_002740595.1 1259040 R 488221 CDS YP_002740596.1 225859086 7685075 1259393..1260793 1 NC_012468.1 identified by match to protein family HMM PF01966; dGTP triphosphohydrolase 1260793 7685075 SP70585_1355 Streptococcus pneumoniae 70585 dGTP triphosphohydrolase YP_002740596.1 1259393 D 488221 CDS YP_002740597.1 225859087 7684609 1260806..1261612 1 NC_012468.1 identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; phosphatase YidA 1261612 7684609 SP70585_1356 Streptococcus pneumoniae 70585 phosphatase YidA YP_002740597.1 1260806 D 488221 CDS YP_002740598.1 225859088 7683898 complement(1261782..1262129) 1 NC_012468.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 1262129 rplS 7683898 rplS Streptococcus pneumoniae 70585 50S ribosomal protein L19 YP_002740598.1 1261782 R 488221 CDS YP_002740599.1 225859089 7683667 complement(1262248..1262577) 1 NC_012468.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 1262577 7683667 SP70585_1359 Streptococcus pneumoniae 70585 camphor resistance protein CrcB YP_002740599.1 1262248 R 488221 CDS YP_002740600.1 225859090 7684385 complement(1262571..1262945) 1 NC_012468.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 1262945 7684385 SP70585_1360 Streptococcus pneumoniae 70585 camphor resistance protein CrcB YP_002740600.1 1262571 R 488221 CDS YP_002740601.1 225859091 7683071 complement(1262942..1263208) 1 NC_012468.1 identified by match to protein family HMM PF01817; match to protein family HMM TIGR01805; hypothetical protein 1263208 7683071 SP70585_1361 Streptococcus pneumoniae 70585 hypothetical protein YP_002740601.1 1262942 R 488221 CDS YP_002740602.1 225859092 7683811 complement(1263324..1263767) 1 NC_012468.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin 1263767 7683811 SP70585_1362 Streptococcus pneumoniae 70585 flavodoxin YP_002740602.1 1263324 R 488221 CDS YP_002740603.1 225859093 7682917 1263871..1264806 1 NC_012468.1 identified by match to protein family HMM PF01368; match to protein family HMM PF02272; DHH subfamily 1 protein 1264806 7682917 SP70585_1363 Streptococcus pneumoniae 70585 DHH subfamily 1 protein YP_002740603.1 1263871 D 488221 CDS YP_002740604.1 225859094 7683681 1264902..1265144 1 NC_012468.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 type B 1265144 rpmE2 7683681 rpmE2 Streptococcus pneumoniae 70585 50S ribosomal protein L31 type B YP_002740604.1 1264902 D 488221 CDS YP_002740605.1 225859095 7683457 complement(1265201..1265419) 1 NC_012468.1 high-affinity Fe2+/Pb2+ permease 1265419 7683457 SP70585_1365 Streptococcus pneumoniae 70585 high-affinity Fe2+/Pb2+ permease YP_002740605.1 1265201 R 488221 CDS YP_002740606.1 225859096 7684880 complement(1265956..1266360) 1 NC_012468.1 transposase 1266360 7684880 SP70585_1368 Streptococcus pneumoniae 70585 transposase YP_002740606.1 1265956 R 488221 CDS YP_002740607.1 225859097 7683335 1266908..1268254 1 NC_012468.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; glutamate dehydrogenase 1268254 7683335 SP70585_1369 Streptococcus pneumoniae 70585 glutamate dehydrogenase YP_002740607.1 1266908 D 488221 CDS YP_002740608.1 225859098 7683891 complement(1268760..1268930) 1 NC_012468.1 hypothetical protein 1268930 7683891 SP70585_1370 Streptococcus pneumoniae 70585 hypothetical protein YP_002740608.1 1268760 R 488221 CDS YP_002740609.1 225859099 7684074 complement(1268943..1269584) 1 NC_012468.1 identified by match to protein family HMM PF00005; multidrug resistance protein 1 (ATP-binding cassettesub-family B member 1) (P-glycoprotein 1) (antigen) 1269584 7684074 SP70585_1371 Streptococcus pneumoniae 70585 multidrug resistance protein 1 (ATP-binding cassettesub-family B member 1) (P-glycoprotein 1) (antigen) YP_002740609.1 1268943 R 488221 CDS YP_002740610.1 225859100 7683643 1269857..1270453 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase 1270453 7683643 SP70585_1372 Streptococcus pneumoniae 70585 transposase YP_002740610.1 1269857 D 488221 CDS YP_002740611.1 225859101 7683446 complement(1270603..1270806) 1 NC_012468.1 glucokinase 1270806 7683446 SP70585_1373 Streptococcus pneumoniae 70585 glucokinase YP_002740611.1 1270603 R 488221 CDS YP_002740612.1 225859102 7683570 complement(1270824..1271741) 1 NC_012468.1 identified by match to protein family HMM PF00701; N-acetylneuraminate lyase 1271741 7683570 SP70585_1374 Streptococcus pneumoniae 70585 N-acetylneuraminate lyase YP_002740612.1 1270824 R 488221 CDS YP_002740613.1 225859103 7684810 complement(1271773..1272180) 1 NC_012468.1 identified by match to protein family HMM PF00383; match to protein family HMM TIGR01354; cytidine deaminase 1272180 cdd2 7684810 cdd2 Streptococcus pneumoniae 70585 cytidine deaminase YP_002740613.1 1271773 R 488221 CDS YP_002740614.1 225859104 7684533 complement(1272468..1272956) 1 NC_012468.1 identified by match to protein family HMM PF04608; phosphatidylglycerophosphatase A 1272956 pgpA 7684533 pgpA Streptococcus pneumoniae 70585 phosphatidylglycerophosphatase A YP_002740614.1 1272468 R 488221 CDS YP_002740615.1 225859105 7684745 complement(1272961..1274370) 1 NC_012468.1 hypothetical protein 1274370 7684745 SP70585_1377 Streptococcus pneumoniae 70585 hypothetical protein YP_002740615.1 1272961 R 488221 CDS YP_002740616.1 225859106 7685027 complement(1274380..1275939) 1 NC_012468.1 identified by match to protein family HMM PF00005; match to protein family HMM PF08352; match to protein family HMM TIGR01727; glutathione import ATP-binding protein GsiA 1275939 7685027 SP70585_1378 Streptococcus pneumoniae 70585 glutathione import ATP-binding protein GsiA YP_002740616.1 1274380 R 488221 CDS YP_002740617.1 225859107 7684009 complement(1276261..1276398) 1 NC_012468.1 hypothetical protein 1276398 7684009 SP70585_1379 Streptococcus pneumoniae 70585 hypothetical protein YP_002740617.1 1276261 R 488221 CDS YP_002740618.1 225859108 7684626 complement(1276532..1277851) 1 NC_012468.1 hypothetical protein 1277851 7684626 SP70585_1380 Streptococcus pneumoniae 70585 hypothetical protein YP_002740618.1 1276532 R 488221 CDS YP_002740619.1 225859109 7683777 complement(1277854..1278594) 1 NC_012468.1 identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1278594 7683777 SP70585_1381 Streptococcus pneumoniae 70585 ABC transporter ATP-binding protein YP_002740619.1 1277854 R 488221 CDS YP_002740620.1 225859110 7683220 complement(1278609..1280216) 1 NC_012468.1 identified by match to protein family HMM PF00005; match to protein family HMM PF00664; drug efflux ABC transporter ATP-binding/permease protein 1280216 7683220 SP70585_1382 Streptococcus pneumoniae 70585 drug efflux ABC transporter ATP-binding/permease protein YP_002740620.1 1278609 R 488221 CDS YP_002740621.1 225859111 7683830 complement(1280213..1282153) 1 NC_012468.1 identified by match to protein family HMM PF00326; prolyl oligopeptidase family protein 1282153 7683830 SP70585_1383 Streptococcus pneumoniae 70585 prolyl oligopeptidase family protein YP_002740621.1 1280213 R 488221 CDS YP_002740622.1 225859112 7683359 complement(1282186..1284795) 1 NC_012468.1 identified by match to protein family HMM PF05147; hypothetical protein 1284795 7683359 SP70585_1384 Streptococcus pneumoniae 70585 hypothetical protein YP_002740622.1 1282186 R 488221 CDS YP_002740623.1 225859113 7684473 complement(1284974..1285111) 1 NC_012468.1 hypothetical protein 1285111 7684473 SP70585_1385 Streptococcus pneumoniae 70585 hypothetical protein YP_002740623.1 1284974 R 488221 CDS YP_002740624.1 225859114 7684898 complement(1285313..1285900) 1 NC_012468.1 identified by match to protein family HMM PF02517; caax amino protease family 1285900 7684898 SP70585_1386 Streptococcus pneumoniae 70585 caax amino protease family YP_002740624.1 1285313 R 488221 CDS YP_002740625.1 225859115 7683047 complement(1285993..1286136) 1 NC_012468.1 hypothetical protein 1286136 7683047 SP70585_1387 Streptococcus pneumoniae 70585 hypothetical protein YP_002740625.1 1285993 R 488221 CDS YP_002740626.1 225859116 7683945 complement(1286149..1286529) 1 NC_012468.1 hypothetical protein 1286529 7683945 SP70585_1388 Streptococcus pneumoniae 70585 hypothetical protein YP_002740626.1 1286149 R 488221 CDS YP_002740627.1 225859117 7683545 complement(1286522..1286773) 1 NC_012468.1 hypothetical protein 1286773 7683545 SP70585_1389 Streptococcus pneumoniae 70585 hypothetical protein YP_002740627.1 1286522 R 488221 CDS YP_002740628.1 225859118 7684193 complement(1286853..1287017) 1 NC_012468.1 identified by match to protein family HMM PF06970; replication intiation protein 1287017 7684193 SP70585_1390 Streptococcus pneumoniae 70585 replication intiation protein YP_002740628.1 1286853 R 488221 CDS YP_002740629.1 225859119 7684887 complement(1287107..1287229) 1 NC_012468.1 hypothetical protein 1287229 7684887 SP70585_1391 Streptococcus pneumoniae 70585 hypothetical protein YP_002740629.1 1287107 R 488221 CDS YP_002740630.1 225859120 7684427 complement(1287476..1287844) 1 NC_012468.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 1287844 rplL 7684427 rplL Streptococcus pneumoniae 70585 50S ribosomal protein L7/L12 YP_002740630.1 1287476 R 488221 CDS YP_002740631.1 225859121 7684482 complement(1287920..1288420) 1 NC_012468.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 1288420 rplJ 7684482 rplJ Streptococcus pneumoniae 70585 50S ribosomal protein L10 YP_002740631.1 1287920 R 488221 CDS YP_002740632.1 225859122 7685188 1288425..1288574 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 1288574 7685188 SP70585_1394 Streptococcus pneumoniae 70585 hypothetical protein YP_002740632.1 1288425 D 488221 CDS YP_002740633.1 225859123 7685142 complement(1288669..1289928) 1 NC_012468.1 identified by match to protein family HMM PF01979; match to protein family HMM PF07969; chlorohydrolase 1289928 7685142 SP70585_1395 Streptococcus pneumoniae 70585 chlorohydrolase YP_002740633.1 1288669 R 488221 CDS YP_002740634.1 225859124 7684578 complement(1290230..1291978) 1 NC_012468.1 identified by match to protein family HMM PF00005; match to protein family HMM PF00664; ABC transporter ATP-binding protein/permease 1291978 7684578 SP70585_1396 Streptococcus pneumoniae 70585 ABC transporter ATP-binding protein/permease YP_002740634.1 1290230 R 488221 CDS YP_002740635.1 225859125 7684631 complement(1291980..1293704) 1 NC_012468.1 identified by match to protein family HMM PF00005; match to protein family HMM PF00664; ABC transporter ATP-binding protein/permease 1293704 7684631 SP70585_1397 Streptococcus pneumoniae 70585 ABC transporter ATP-binding protein/permease YP_002740635.1 1291980 R 488221 CDS YP_002740636.1 225859126 7684723 complement(1293762..1294700) 1 NC_012468.1 identified by match to protein family HMM PF01625; match to protein family HMM PF01641; match to protein family HMM TIGR00357; match to protein family HMM TIGR00401; peptide methionine sulfoxide reductase MsrA/msrB 1294700 7684723 SP70585_1398 Streptococcus pneumoniae 70585 peptide methionine sulfoxide reductase MsrA/msrB YP_002740636.1 1293762 R 488221 CDS YP_002740637.1 225859127 7685085 complement(1294995..1295864) 1 NC_012468.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase 1295864 thrB 7685085 thrB Streptococcus pneumoniae 70585 homoserine kinase YP_002740637.1 1294995 R 488221 CDS YP_002740638.1 225859128 7685025 complement(1295866..1297152) 1 NC_012468.1 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine; homoserine dehydrogenase 1297152 7685025 SP70585_1400 Streptococcus pneumoniae 70585 homoserine dehydrogenase YP_002740638.1 1295866 R 488221 CDS YP_002740639.1 225859129 7684096 complement(1297303..1298040) 1 NC_012468.1 enables recognition and targeting of proteins for proteolysis, involved in negative regulation of competence; adaptor protein 1298040 7684096 SP70585_1401 Streptococcus pneumoniae 70585 adaptor protein YP_002740639.1 1297303 R 488221 CDS YP_002740640.1 225859130 7683408 complement(1298240..1299274) 1 NC_012468.1 hypothetical protein 1299274 7683408 SP70585_1402 Streptococcus pneumoniae 70585 hypothetical protein YP_002740640.1 1298240 R 488221 CDS YP_002740641.1 225859131 7682935 complement(1299303..1300736) 1 NC_012468.1 hypothetical protein 1300736 7682935 SP70585_1403 Streptococcus pneumoniae 70585 hypothetical protein YP_002740641.1 1299303 R 488221 CDS YP_002740642.1 225859132 7683294 complement(1300752..1301738) 1 NC_012468.1 identified by match to protein family HMM PF00535; galactosyl transferase 1301738 7683294 SP70585_1404 Streptococcus pneumoniae 70585 galactosyl transferase YP_002740642.1 1300752 R 488221 CDS YP_002740643.1 225859133 7683498 complement(1301740..1302840) 1 NC_012468.1 identified by match to protein family HMM PF00534; glycosyl transferase, group 1 family protein 1302840 7683498 SP70585_1405 Streptococcus pneumoniae 70585 glycosyl transferase, group 1 family protein YP_002740643.1 1301740 R 488221 CDS YP_002740644.1 225859134 7684064 complement(1302833..1303678) 1 NC_012468.1 identified by match to protein family HMM PF04991; licD3 protein 1303678 7684064 SP70585_1406 Streptococcus pneumoniae 70585 licD3 protein YP_002740644.1 1302833 R 488221 CDS YP_002740645.1 225859135 7683117 complement(1303957..1305231) 1 NC_012468.1 identified by match to protein family HMM PF03816; match to protein family HMM TIGR00350; transcriptional regulator, LytR family 1305231 7683117 SP70585_1407 Streptococcus pneumoniae 70585 transcriptional regulator, LytR family YP_002740645.1 1303957 R 488221 CDS YP_002740646.1 225859136 7684663 complement(1305228..1306076) 1 NC_012468.1 catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; prephenate dehydratase 1306076 7684663 SP70585_1408 Streptococcus pneumoniae 70585 prephenate dehydratase YP_002740646.1 1305228 R 488221 CDS YP_002740647.1 225859137 7685113 complement(1306073..1306549) 1 NC_012468.1 identified by match to protein family HMM PF01202; shikimate kinase 1306549 aroK 7685113 aroK Streptococcus pneumoniae 70585 shikimate kinase YP_002740647.1 1306073 R 488221 CDS YP_002740648.1 225859138 7684465 complement(1306542..1307825) 1 NC_012468.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase 1307825 aroA 7684465 aroA Streptococcus pneumoniae 70585 3-phosphoshikimate 1-carboxyvinyltransferase YP_002740648.1 1306542 R 488221 CDS YP_002740649.1 225859139 7683516 complement(1307917..1308255) 1 NC_012468.1 identified by match to protein family HMM PF06133; hypothetical protein 1308255 7683516 SP70585_1411 Streptococcus pneumoniae 70585 hypothetical protein YP_002740649.1 1307917 R 488221 CDS YP_002740650.1 225859140 7685073 complement(1308266..1309369) 1 NC_012468.1 catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate; prephenate dehydrogenase 1309369 7685073 SP70585_1412 Streptococcus pneumoniae 70585 prephenate dehydrogenase YP_002740650.1 1308266 R 488221 CDS YP_002740651.1 225859141 7683665 complement(1309379..1310545) 1 NC_012468.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase 1310545 aroC 7683665 aroC Streptococcus pneumoniae 70585 chorismate synthase YP_002740651.1 1309379 R 488221 CDS YP_002740652.1 225859142 7683055 complement(1310555..1311622) 1 NC_012468.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 1311622 aroB 7683055 aroB Streptococcus pneumoniae 70585 3-dehydroquinate synthase YP_002740652.1 1310555 R 488221 CDS YP_002740653.1 225859143 7683129 complement(1311641..1312495) 1 NC_012468.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase 1312495 aroE 7683129 aroE Streptococcus pneumoniae 70585 shikimate 5-dehydrogenase YP_002740653.1 1311641 R 488221 CDS YP_002740654.1 225859144 7683034 complement(1312485..1313162) 1 NC_012468.1 catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis; 3-dehydroquinate dehydratase 1313162 aroD 7683034 aroD Streptococcus pneumoniae 70585 3-dehydroquinate dehydratase YP_002740654.1 1312485 R 488221 CDS YP_002740655.1 225859145 7683144 complement(1313159..1314322) 1 NC_012468.1 methyltransferase 1314322 7683144 SP70585_1417 Streptococcus pneumoniae 70585 methyltransferase YP_002740655.1 1313159 R 488221 CDS YP_002740656.1 225859146 7684969 complement(1315007..1316641) 1 NC_012468.1 hypothetical protein 1316641 7684969 SP70585_1418 Streptococcus pneumoniae 70585 hypothetical protein YP_002740656.1 1315007 R 488221 CDS YP_002740657.1 225859147 7683700 complement(1316622..1317371) 1 NC_012468.1 identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1317371 7683700 SP70585_1419 Streptococcus pneumoniae 70585 ABC transporter ATP-binding protein YP_002740657.1 1316622 R 488221 CDS YP_002740658.1 225859148 7684360 1317550..1319004 1 NC_012468.1 converts 1,4-alpha-D-glucans to maltodextrin; cytoplasmic alpha-amylase 1319004 7684360 SP70585_1420 Streptococcus pneumoniae 70585 cytoplasmic alpha-amylase YP_002740658.1 1317550 D 488221 CDS YP_002740659.1 225859149 7684267 complement(1319094..1321712) 1 NC_012468.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 1321712 alaS 7684267 alaS Streptococcus pneumoniae 70585 alanyl-tRNA synthetase YP_002740659.1 1319094 R 488221 CDS YP_002740660.1 225859150 7684622 complement(1321734..1322219) 1 NC_012468.1 identified by match to protein family HMM PF04525; hypothetical protein 1322219 7684622 SP70585_1422 Streptococcus pneumoniae 70585 hypothetical protein YP_002740660.1 1321734 R 488221 CDS YP_002740661.1 225859151 7684024 complement(1322494..1322733) 1 NC_012468.1 hypothetical protein 1322733 7684024 SP70585_1423 Streptococcus pneumoniae 70585 hypothetical protein YP_002740661.1 1322494 R 488221 CDS YP_002740662.1 225859152 7685161 complement(1322994..1324064) 1 NC_012468.1 identified by match to protein family HMM PF01547; spermidine/putrescine ABC transporter spermidine/putrescine-binding protein 1324064 7685161 SP70585_1424 Streptococcus pneumoniae 70585 spermidine/putrescine ABC transporter spermidine/putrescine-binding protein YP_002740662.1 1322994 R 488221 CDS YP_002740663.1 225859153 7684129 complement(1324061..1324834) 1 NC_012468.1 identified by match to protein family HMM PF00528; spermidine/putrescine ABC transporter permease 1324834 7684129 SP70585_1425 Streptococcus pneumoniae 70585 spermidine/putrescine ABC transporter permease YP_002740663.1 1324061 R 488221 CDS YP_002740664.1 225859154 7684588 complement(1324831..1325637) 1 NC_012468.1 identified by match to protein family HMM PF00528; spermidine/putrescine ABC transporter permease 1325637 7684588 SP70585_1426 Streptococcus pneumoniae 70585 spermidine/putrescine ABC transporter permease YP_002740664.1 1324831 R 488221 CDS YP_002740665.1 225859155 7683819 complement(1325618..1326775) 1 NC_012468.1 identified by match to protein family HMM PF00005; match to protein family HMM PF08402; spermidine/putrescine import ATP-binding protein PotA 1326775 7683819 SP70585_1427 Streptococcus pneumoniae 70585 spermidine/putrescine import ATP-binding protein PotA YP_002740665.1 1325618 R 488221 CDS YP_002740666.1 225859156 7683323 complement(1326936..1327841) 1 NC_012468.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 1327841 murB 7683323 murB Streptococcus pneumoniae 70585 UDP-N-acetylenolpyruvoylglucosamine reductase YP_002740666.1 1326936 R 488221 CDS YP_002740667.1 225859157 7683218 complement(1328715..1329446) 1 NC_012468.1 identified by match to protein family HMM PF03306; match to protein family HMM TIGR01252; alpha-acetolactate decarboxylase 1329446 budA 7683218 budA Streptococcus pneumoniae 70585 alpha-acetolactate decarboxylase YP_002740667.1 1328715 R 488221 CDS YP_002740668.1 225859158 7684693 1329588..1330859 1 NC_012468.1 identified by match to protein family HMM PF00392; GntR family transcriptional regulator 1330859 7684693 SP70585_1432 Streptococcus pneumoniae 70585 GntR family transcriptional regulator YP_002740668.1 1329588 D 488221 CDS YP_002740669.1 225859159 7683137 complement(1330879..1331694) 1 NC_012468.1 identified by match to protein family HMM PF00497; amino acid ABC transporter substrate-binding protein 1331694 7683137 SP70585_1433 Streptococcus pneumoniae 70585 amino acid ABC transporter substrate-binding protein YP_002740669.1 1330879 R 488221 CDS YP_002740670.1 225859160 7685106 complement(1331851..1332504) 1 NC_012468.1 identified by match to protein family HMM PF01895; match to protein family HMM TIGR02135; phosphate transport system regulatory protein PhoU 1332504 phoU1 7685106 phoU1 Streptococcus pneumoniae 70585 phosphate transport system regulatory protein PhoU YP_002740670.1 1331851 R 488221 CDS YP_002740671.1 225859161 7684732 complement(1332516..1333274) 1 NC_012468.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein 1333274 pstB1 7684732 pstB1 Streptococcus pneumoniae 70585 phosphate transporter ATP-binding protein YP_002740671.1 1332516 R 488221 CDS YP_002740672.1 225859162 7683500 complement(1333287..1334090) 1 NC_012468.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein 1334090 pstB2 7683500 pstB2 Streptococcus pneumoniae 70585 phosphate transporter ATP-binding protein YP_002740672.1 1333287 R 488221 CDS YP_002740673.1 225859163 7684569 complement(1334101..1334985) 1 NC_012468.1 identified by match to protein family HMM PF00528; match to protein family HMM TIGR00974; phosphate ABC transporter permease 1334985 pstA1 7684569 pstA1 Streptococcus pneumoniae 70585 phosphate ABC transporter permease YP_002740673.1 1334101 R 488221 CDS YP_002740674.1 225859164 7684428 complement(1334975..1335892) 1 NC_012468.1 identified by match to protein family HMM PF00528; match to protein family HMM TIGR02138; phosphate ABC transporter permease 1335892 pstC1 7684428 pstC1 Streptococcus pneumoniae 70585 phosphate ABC transporter permease YP_002740674.1 1334975 R 488221 CDS YP_002740675.1 225859165 7683328 complement(1335892..1336770) 1 NC_012468.1 identified by match to protein family HMM PF01547; match to protein family HMM TIGR02136; phosphate-binding protein PstS 1 (PBP 1) 1336770 7683328 SP70585_1439 Streptococcus pneumoniae 70585 phosphate-binding protein PstS 1 (PBP 1) YP_002740675.1 1335892 R 488221 CDS YP_002740676.1 225859166 7683832 1337000..1337113 1 NC_012468.1 hypothetical protein 1337113 7683832 SP70585_1440 Streptococcus pneumoniae 70585 hypothetical protein YP_002740676.1 1337000 D 488221 CDS YP_002740677.1 225859167 7683523 complement(1337344..1338648) 1 NC_012468.1 identified by match to protein family HMM PF01189; NOL1/NOP2/sun family protein 1338648 7683523 SP70585_1441 Streptococcus pneumoniae 70585 NOL1/NOP2/sun family protein YP_002740677.1 1337344 R 488221 CDS YP_002740678.1 225859168 7684463 complement(1338649..1339422) 1 NC_012468.1 identified by match to protein family HMM PF00459; inositol monophosphatase family protein 1339422 7684463 SP70585_1442 Streptococcus pneumoniae 70585 inositol monophosphatase family protein YP_002740678.1 1338649 R 488221 CDS YP_002740679.1 225859169 7683547 complement(1339412..1339690) 1 NC_012468.1 identified by match to protein family HMM PF05256; hypothetical protein 1339690 7683547 SP70585_1443 Streptococcus pneumoniae 70585 hypothetical protein YP_002740679.1 1339412 R 488221 CDS YP_002740680.1 225859170 7684488 complement(1339690..1340091) 1 NC_012468.1 the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress; transcriptional regulator Spx 1340091 spxA 7684488 spxA Streptococcus pneumoniae 70585 transcriptional regulator Spx YP_002740680.1 1339690 R 488221 CDS YP_002740681.1 225859171 7682945 complement(1340301..1340918) 1 NC_012468.1 identified by match to protein family HMM PF07314; match to protein family HMM TIGR01906; integral membrane protein 1340918 7682945 SP70585_1445 Streptococcus pneumoniae 70585 integral membrane protein YP_002740681.1 1340301 R 488221 CDS YP_002740682.1 225859172 7684324 complement(1340908..1341681) 1 NC_012468.1 identified by match to protein family HMM PF00702; match to protein family HMM TIGR01457; match to protein family HMM TIGR01460; HAD-superfamily subfamily IIA hydrolase 1341681 7684324 SP70585_1446 Streptococcus pneumoniae 70585 HAD-superfamily subfamily IIA hydrolase YP_002740682.1 1340908 R 488221 CDS YP_002740683.1 225859173 7683989 complement(1341692..1342429) 1 NC_012468.1 identified by match to protein family HMM PF01643; acyl-ACP thioesterase 1342429 7683989 SP70585_1447 Streptococcus pneumoniae 70585 acyl-ACP thioesterase YP_002740683.1 1341692 R 488221 CDS YP_002740684.1 225859174 7684127 complement(1342434..1343564) 1 NC_012468.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 1343564 7684127 SP70585_1448 Streptococcus pneumoniae 70585 coproporphyrinogen III oxidase YP_002740684.1 1342434 R 488221 CDS YP_002740685.1 225859175 7684149 complement(1343648..1344037) 1 NC_012468.1 hypothetical protein 1344037 7684149 SP70585_1449 Streptococcus pneumoniae 70585 hypothetical protein YP_002740685.1 1343648 R 488221 CDS YP_002740686.1 225859176 7683079 complement(1344053..1344436) 1 NC_012468.1 identified by match to protein family HMM PF06103; hypothetical protein 1344436 7683079 SP70585_1450 Streptococcus pneumoniae 70585 hypothetical protein YP_002740686.1 1344053 R 488221 CDS YP_002740687.1 225859177 7684688 complement(1344437..1345225) 1 NC_012468.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase 1345225 lgt 7684688 lgt Streptococcus pneumoniae 70585 prolipoprotein diacylglyceryl transferase YP_002740687.1 1344437 R 488221 CDS YP_002740688.1 225859178 7683131 complement(1345218..1346153) 1 NC_012468.1 catalyzes the phosphorylation of the phosphocarrier protein HPr of the bacterial phosphotransferase system; HPr kinase/phosphorylase 1346153 hprK 7683131 hprK Streptococcus pneumoniae 70585 HPr kinase/phosphorylase YP_002740688.1 1345218 R 488221 CDS YP_002740689.1 225859179 7683285 complement(1346283..1346459) 1 NC_012468.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 1346459 rpsU 7683285 rpsU Streptococcus pneumoniae 70585 30S ribosomal protein S21 YP_002740689.1 1346283 R 488221 CDS YP_002740690.1 225859180 7682925 complement(1346599..1347306) 1 NC_012468.1 identified by match to protein family HMM PF01182; glucosamine-6-phosphate deaminase (glucosamine-6-phosphate isomerase) (gnpda) (glcn6p deaminase) 1347306 7682925 SP70585_1454 Streptococcus pneumoniae 70585 glucosamine-6-phosphate deaminase (glucosamine-6-phosphate isomerase) (gnpda) (glcn6p deaminase) YP_002740690.1 1346599 R 488221 CDS YP_002740691.1 225859181 7683626 1347457..1348485 1 NC_012468.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine:tRNA ribosyltransferase-isomerase 1348485 queA 7683626 queA Streptococcus pneumoniae 70585 S-adenosylmethionine:tRNA ribosyltransferase-isomerase YP_002740691.1 1347457 D 488221 CDS YP_002740692.1 225859182 7683475 complement(1349146..1349535) 1 NC_012468.1 identified by match to protein family HMM PF01473; choline binding protein 1349535 7683475 SP70585_1456 Streptococcus pneumoniae 70585 choline binding protein YP_002740692.1 1349146 R 488221 CDS YP_002740693.1 225859183 7684235 complement(1351004..1351555) 1 NC_012468.1 identified by match to protein family HMM PF00583; acetyltransferase, gnat family 1351555 7684235 SP70585_1457 Streptococcus pneumoniae 70585 acetyltransferase, gnat family YP_002740693.1 1351004 R 488221 CDS YP_002740694.1 225859184 7684673 complement(1351905..1352729) 1 NC_012468.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase 1352729 nadE 7684673 nadE Streptococcus pneumoniae 70585 NAD synthetase YP_002740694.1 1351905 R 488221 CDS YP_002740695.1 225859185 7685063 complement(1352726..1354186) 1 NC_012468.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase 1354186 pncB 7685063 pncB Streptococcus pneumoniae 70585 nicotinate phosphoribosyltransferase YP_002740695.1 1352726 R 488221 CDS YP_002740696.1 225859186 7684737 complement(1354302..1354790) 1 NC_012468.1 hypothetical protein 1354790 7684737 SP70585_1460 Streptococcus pneumoniae 70585 hypothetical protein YP_002740696.1 1354302 R 488221 CDS YP_002740697.1 225859187 7683581 complement(1354780..1354989) 1 NC_012468.1 identified by match to protein family HMM PF01381; hypothetical protein 1354989 7683581 SP70585_1461 Streptococcus pneumoniae 70585 hypothetical protein YP_002740697.1 1354780 R 488221 CDS YP_002740698.1 225859188 7684643 complement(1355375..1356103) 1 NC_012468.1 hypothetical protein 1356103 7684643 SP70585_1462 Streptococcus pneumoniae 70585 hypothetical protein YP_002740698.1 1355375 R 488221 CDS YP_002740699.1 225859189 7684369 complement(1356119..1356607) 1 NC_012468.1 multidrug ABC transporter ATP-binding protein 1356607 7684369 SP70585_1463 Streptococcus pneumoniae 70585 multidrug ABC transporter ATP-binding protein YP_002740699.1 1356119 R 488221 CDS YP_002740700.1 225859190 7683766 1356636..1357097 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase 1357097 7683766 SP70585_1464 Streptococcus pneumoniae 70585 transposase YP_002740700.1 1356636 D 488221 CDS YP_002740701.1 225859191 7683311 1357109..1357486 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01609; transposase (IS4 family) 1357486 7683311 SP70585_1466 Streptococcus pneumoniae 70585 transposase (IS4 family) YP_002740701.1 1357109 D 488221 CDS YP_002740702.1 225859192 7683846 complement(1357451..1357870) 1 NC_012468.1 ABC transporter ATP-binding protein 1357870 7683846 SP70585_1465 Streptococcus pneumoniae 70585 ABC transporter ATP-binding protein YP_002740702.1 1357451 R 488221 CDS YP_002740703.1 225859193 7684750 complement(1358205..1358930) 1 NC_012468.1 identified by match to protein family HMM PF01136; peptidase, U32 family 1358930 7684750 SP70585_1467 Streptococcus pneumoniae 70585 peptidase, U32 family YP_002740703.1 1358205 R 488221 CDS YP_002740704.1 225859194 7682958 1359101..1359250 1 NC_012468.1 hypothetical protein 1359250 7682958 SP70585_1468 Streptococcus pneumoniae 70585 hypothetical protein YP_002740704.1 1359101 D 488221 CDS YP_002740705.1 225859195 7684102 complement(1359505..1360791) 1 NC_012468.1 identified by match to protein family HMM PF01136; peptidase, U32 family protein 1360791 7684102 SP70585_1469 Streptococcus pneumoniae 70585 peptidase, U32 family protein YP_002740705.1 1359505 R 488221 CDS YP_002740706.1 225859196 7685122 1361415..1361597 1 NC_012468.1 restriction endonuclease R.XbaI 1361597 7685122 SP70585_1470 Streptococcus pneumoniae 70585 restriction endonuclease R.XbaI YP_002740706.1 1361415 D 488221 CDS YP_002740707.1 225859197 7683072 1361781..1361972 1 NC_012468.1 restriction endonuclease R.XbaI 1361972 7683072 SP70585_1471 Streptococcus pneumoniae 70585 restriction endonuclease R.XbaI YP_002740707.1 1361781 D 488221 CDS YP_002740708.1 225859198 7684639 1361969..1363159 1 NC_012468.1 identified by match to protein family HMM PF01555; DNA modification methyltransferase M.XbaI 1363159 7684639 SP70585_1472 Streptococcus pneumoniae 70585 DNA modification methyltransferase M.XbaI YP_002740708.1 1361969 D 488221 CDS YP_002740709.1 225859199 7682879 1363406..1363552 1 NC_012468.1 hypothetical protein 1363552 7682879 SP70585_1473 Streptococcus pneumoniae 70585 hypothetical protein YP_002740709.1 1363406 D 488221 CDS YP_002740710.1 225859200 7683360 complement(1363674..1364666) 1 NC_012468.1 identified by match to protein family HMM PF00165; AraC family transcriptional regulator 1364666 7683360 SP70585_1474 Streptococcus pneumoniae 70585 AraC family transcriptional regulator YP_002740710.1 1363674 R 488221 CDS YP_002740711.1 225859201 7683474 1364826..1366580 1 NC_012468.1 identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein/permease 1366580 7683474 SP70585_1475 Streptococcus pneumoniae 70585 ABC transporter ATP-binding protein/permease YP_002740711.1 1364826 D 488221 CDS YP_002740712.1 225859202 7684240 1366564..1368318 1 NC_012468.1 identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1368318 7684240 SP70585_1476 Streptococcus pneumoniae 70585 ABC transporter ATP-binding protein YP_002740712.1 1366564 D 488221 CDS YP_002740713.1 225859203 7684903 1368300..1368884 1 NC_012468.1 identified by match to protein family HMM TIGR02185; hypothetical protein 1368884 7684903 SP70585_1477 Streptococcus pneumoniae 70585 hypothetical protein YP_002740713.1 1368300 D 488221 CDS YP_002740714.1 225859204 7684780 1368884..1369579 1 NC_012468.1 identified by match to protein family HMM PF02361; cobalt transport protein 1369579 7684780 SP70585_1478 Streptococcus pneumoniae 70585 cobalt transport protein YP_002740714.1 1368884 D 488221 CDS YP_002740715.1 225859205 7683622 1369567..1370931 1 NC_012468.1 identified by match to protein family HMM PF00005; cobalt ABC transporter ATPase component, CbiO 1370931 7683622 SP70585_1479 Streptococcus pneumoniae 70585 cobalt ABC transporter ATPase component, CbiO YP_002740715.1 1369567 D 488221 CDS YP_002740716.1 225859206 7683280 complement(1373231..1373554) 1 NC_012468.1 identified by match to protein family HMM PF05717; IS66 family element, Orf2 1373554 7683280 SP70585_1483 Streptococcus pneumoniae 70585 IS66 family element, Orf2 YP_002740716.1 1373231 R 488221 CDS YP_002740717.1 225859207 7684640 complement(1373535..1373720) 1 NC_012468.1 hypothetical protein 1373720 7684640 SP70585_1484 Streptococcus pneumoniae 70585 hypothetical protein YP_002740717.1 1373535 R 488221 CDS YP_002740718.1 225859208 7683614 complement(1374024..1375586) 1 NC_012468.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 1375586 guaA 7683614 guaA Streptococcus pneumoniae 70585 GMP synthase YP_002740718.1 1374024 R 488221 CDS YP_002740719.1 225859209 7684445 1375728..1376426 1 NC_012468.1 identified by match to protein family HMM PF00392; match to protein family HMM PF07702; GntR family transcriptional regulator 1376426 7684445 SP70585_1486 Streptococcus pneumoniae 70585 GntR family transcriptional regulator YP_002740719.1 1375728 D 488221 CDS YP_002740720.1 225859210 7682953 complement(1376469..1377365) 1 NC_012468.1 identified by match to protein family HMM PF00892; membrane protein 1377365 7682953 SP70585_1487 Streptococcus pneumoniae 70585 membrane protein YP_002740720.1 1376469 R 488221 CDS YP_002740721.1 225859211 7683397 complement(1377374..1378309) 1 NC_012468.1 identified by match to protein family HMM PF00144; beta-lactamase 1378309 7683397 SP70585_1488 Streptococcus pneumoniae 70585 beta-lactamase YP_002740721.1 1377374 R 488221 CDS YP_002740722.1 225859212 7683458 complement(1378306..1379031) 1 NC_012468.1 CppA protein 1379031 7683458 SP70585_1489 Streptococcus pneumoniae 70585 CppA protein YP_002740722.1 1378306 R 488221 CDS YP_002740723.1 225859213 7683631 complement(1379115..1379750) 1 NC_012468.1 identified by match to protein family HMM PF00657; hypothetical protein 1379750 7683631 SP70585_1490 Streptococcus pneumoniae 70585 hypothetical protein YP_002740723.1 1379115 R 488221 CDS YP_002740724.1 225859214 7684568 complement(1379752..1380579) 1 NC_012468.1 identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; hydrolase 1380579 7684568 SP70585_1491 Streptococcus pneumoniae 70585 hydrolase YP_002740724.1 1379752 R 488221 CDS YP_002740725.1 225859215 7685137 1381742..1381855 1 NC_012468.1 hypothetical protein 1381855 7685137 SP70585_1496 Streptococcus pneumoniae 70585 hypothetical protein YP_002740725.1 1381742 D 488221 CDS YP_002740726.1 225859216 7683175 complement(1381809..1381958) 1 NC_012468.1 hypothetical protein 1381958 7683175 SP70585_1495 Streptococcus pneumoniae 70585 hypothetical protein YP_002740726.1 1381809 R 488221 CDS YP_002740727.1 225859217 7684133 1382179..1382790 1 NC_012468.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 1382790 def 7684133 def Streptococcus pneumoniae 70585 peptide deformylase YP_002740727.1 1382179 D 488221 CDS YP_002740728.1 225859218 7684896 1382835..1383563 1 NC_012468.1 identified by match to protein family HMM PF00588; match to protein family HMM PF08032; match to protein family HMM TIGR00186; RNA methyltransferase, TrmH family, group 3 1383563 7684896 SP70585_1498 Streptococcus pneumoniae 70585 RNA methyltransferase, TrmH family, group 3 YP_002740728.1 1382835 D 488221 CDS YP_002740729.1 225859219 7682950 complement(1383602..1384513) 1 NC_012468.1 identified by match to protein family HMM PF00070; match to protein family HMM PF01134; match to protein family HMM PF03486; match to protein family HMM PF07992; match to protein family HMM TIGR01292; thioredoxin-disulfide reductase 1384513 trxB 7682950 trxB Streptococcus pneumoniae 70585 thioredoxin-disulfide reductase YP_002740729.1 1383602 R 488221 CDS YP_002740730.1 225859220 7683413 complement(1384579..1384803) 1 NC_012468.1 hypothetical protein 1384803 7683413 SP70585_1500 Streptococcus pneumoniae 70585 hypothetical protein YP_002740730.1 1384579 R 488221 CDS YP_002740731.1 225859221 7683637 complement(1384881..1385624) 1 NC_012468.1 identified by match to protein family HMM PF00005; L-cystine import ATP-binding protein TcyN 1385624 7683637 SP70585_1501 Streptococcus pneumoniae 70585 L-cystine import ATP-binding protein TcyN YP_002740731.1 1384881 R 488221 CDS YP_002740732.1 225859222 7683461 complement(1385624..1386424) 1 NC_012468.1 identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; aspartate/glutamate ABC transporter permease 1386424 7683461 SP70585_1502 Streptococcus pneumoniae 70585 aspartate/glutamate ABC transporter permease YP_002740732.1 1385624 R 488221 CDS YP_002740733.1 225859223 7684506 complement(1386582..1386938) 1 NC_012468.1 identified by match to protein family HMM PF03960; match to protein family HMM TIGR01617; arsenate reductase 1386938 7684506 SP70585_1503 Streptococcus pneumoniae 70585 arsenate reductase YP_002740733.1 1386582 R 488221 CDS YP_002740734.1 225859224 7683527 complement(1386932..1387462) 1 NC_012468.1 identified by match to protein family HMM PF01035; match to protein family HMM TIGR00589; O6-methylguanine-DNA methyltransferase 1387462 7683527 SP70585_1504 Streptococcus pneumoniae 70585 O6-methylguanine-DNA methyltransferase YP_002740734.1 1386932 R 488221 CDS YP_002740735.1 225859225 7684178 complement(1387462..1387956) 1 NC_012468.1 identified by match to protein family HMM PF00583; acetyltransferase, gnat family 1387956 7684178 SP70585_1505 Streptococcus pneumoniae 70585 acetyltransferase, gnat family YP_002740735.1 1387462 R 488221 CDS YP_002740736.1 225859226 7684870 1388091..1388537 1 NC_012468.1 identified by match to protein family HMM PF08876; hypothetical protein 1388537 7684870 SP70585_1506 Streptococcus pneumoniae 70585 hypothetical protein YP_002740736.1 1388091 D 488221 CDS YP_002740737.1 225859227 7684119 1388534..1389181 1 NC_012468.1 identified by match to protein family HMM PF03006; match to protein family HMM TIGR01065; hemolysin-3 (Hemolysin III) (Hly-III) 1389181 7684119 SP70585_1507 Streptococcus pneumoniae 70585 hemolysin-3 (Hemolysin III) (Hly-III) YP_002740737.1 1388534 D 488221 CDS YP_002740738.1 225859228 7684584 complement(1389202..1389783) 1 NC_012468.1 with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate; glutamine amidotransferase subunit PdxT 1389783 7684584 SP70585_1508 Streptococcus pneumoniae 70585 glutamine amidotransferase subunit PdxT YP_002740738.1 1389202 R 488221 CDS YP_002740739.1 225859229 7684777 complement(1389784..1390659) 1 NC_012468.1 with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate; pyridoxal biosynthesis lyase PdxS 1390659 7684777 SP70585_1509 Streptococcus pneumoniae 70585 pyridoxal biosynthesis lyase PdxS YP_002740739.1 1389784 R 488221 CDS YP_002740740.1 225859230 7684911 complement(1390811..1392190) 1 NC_012468.1 identified by match to protein family HMM PF00070; match to protein family HMM PF02852; match to protein family HMM PF07992; NADH oxidase (noxase) 1392190 7684911 SP70585_1510 Streptococcus pneumoniae 70585 NADH oxidase (noxase) YP_002740740.1 1390811 R 488221 CDS YP_002740741.1 225859231 7684823 1392332..1392487 1 NC_012468.1 hypothetical protein 1392487 7684823 SP70585_1511 Streptococcus pneumoniae 70585 hypothetical protein YP_002740741.1 1392332 D 488221 CDS YP_002740742.1 225859232 7682954 1392484..1393407 1 NC_012468.1 identified by match to protein family HMM PF02424; thiamine biosynthesis lipoprotein 1393407 7682954 SP70585_1512 Streptococcus pneumoniae 70585 thiamine biosynthesis lipoprotein YP_002740742.1 1392484 D 488221 CDS YP_002740743.1 225859233 7683380 1393467..1394072 1 NC_012468.1 identified by match to protein family HMM PF03358; NADPH-dependent fmn reductase domain protein 1394072 7683380 SP70585_1513 Streptococcus pneumoniae 70585 NADPH-dependent fmn reductase domain protein YP_002740743.1 1393467 D 488221 CDS YP_002740744.1 225859234 7683496 1394091..1395335 1 NC_012468.1 identified by match to protein family HMM PF03358; NADPH-dependent fmn reductase domain protein 1395335 7683496 SP70585_1514 Streptococcus pneumoniae 70585 NADPH-dependent fmn reductase domain protein YP_002740744.1 1394091 D 488221 CDS YP_002740745.1 225859235 7683802 complement(1395452..1395709) 1 NC_012468.1 identified by match to protein family HMM PF05979; hypothetical protein 1395709 7683802 SP70585_1515 Streptococcus pneumoniae 70585 hypothetical protein YP_002740745.1 1395452 R 488221 CDS YP_002740746.1 225859236 7684075 complement(1395751..1397787) 1 NC_012468.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta 1397787 glyS 7684075 glyS Streptococcus pneumoniae 70585 glycyl-tRNA synthetase subunit beta YP_002740746.1 1395751 R 488221 CDS YP_002740747.1 225859237 7683150 complement(1398047..1398964) 1 NC_012468.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha 1398964 glyQ 7683150 glyQ Streptococcus pneumoniae 70585 glycyl-tRNA synthetase subunit alpha YP_002740747.1 1398047 R 488221 CDS YP_002740748.1 225859238 7684848 complement(1399332..1400093) 1 NC_012468.1 hypothetical protein 1400093 7684848 SP70585_1518 Streptococcus pneumoniae 70585 hypothetical protein YP_002740748.1 1399332 R 488221 CDS YP_002740749.1 225859239 7683774 complement(1400366..1401208) 1 NC_012468.1 identified by match to protein family HMM PF00248; 2,5-diketo-D-gluconic acid reductase A 1401208 7683774 SP70585_1519 Streptococcus pneumoniae 70585 2,5-diketo-D-gluconic acid reductase A YP_002740749.1 1400366 R 488221 CDS YP_002740750.1 225859240 7684807 complement(1401322..1402659) 1 NC_012468.1 identified by match to protein family HMM PF01522; peptidoglycan GlcNAc deacetylase 1402659 7684807 SP70585_1520 Streptococcus pneumoniae 70585 peptidoglycan GlcNAc deacetylase YP_002740750.1 1401322 R 488221 CDS YP_002740751.1 225859241 7684917 complement(1402948..1403325) 1 NC_012468.1 hypothetical protein 1403325 7684917 SP70585_1521 Streptococcus pneumoniae 70585 hypothetical protein YP_002740751.1 1402948 R 488221 CDS YP_002740752.1 225859242 7684800 1403558..1404535 1 NC_012468.1 identified by match to protein family HMM PF01118; match to protein family HMM PF01408; oxidoreductase 1404535 7684800 SP70585_1522 Streptococcus pneumoniae 70585 oxidoreductase YP_002740752.1 1403558 D 488221 CDS YP_002740753.1 225859243 7685145 1404532..1405614 1 NC_012468.1 identified by match to protein family HMM PF00270; match to protein family HMM PF00271; DEAD RNA helicase 1405614 7685145 SP70585_1523 Streptococcus pneumoniae 70585 DEAD RNA helicase YP_002740753.1 1404532 D 488221 CDS YP_002740754.1 225859244 7683005 complement(1405750..1406187) 1 NC_012468.1 transposase 1406187 7683005 SP70585_1524 Streptococcus pneumoniae 70585 transposase YP_002740754.1 1405750 R 488221 CDS YP_002740755.1 225859245 7683838 complement(1406219..1406485) 1 NC_012468.1 transposase 1406485 7683838 SP70585_1525 Streptococcus pneumoniae 70585 transposase YP_002740755.1 1406219 R 488221 CDS YP_002740756.1 225859246 7683353 complement(1406563..1406724) 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase 1406724 7683353 SP70585_1526 Streptococcus pneumoniae 70585 transposase YP_002740756.1 1406563 R 488221 CDS YP_002740757.1 225859247 7684439 complement(1407108..1408304) 1 NC_012468.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 1408304 tuf 7684439 tuf Streptococcus pneumoniae 70585 elongation factor Tu YP_002740757.1 1407108 R 488221 CDS YP_002740758.1 225859248 7684008 complement(1408736..1409113) 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01609; transposase (IS4 family) 1409113 7684008 SP70585_1528 Streptococcus pneumoniae 70585 transposase (IS4 family) YP_002740758.1 1408736 R 488221 CDS YP_002740759.1 225859249 7683179 complement(1409125..1409586) 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase 1409586 7683179 SP70585_1529 Streptococcus pneumoniae 70585 transposase YP_002740759.1 1409125 R 488221 CDS YP_002740760.1 225859250 7683586 complement(1410099..1410968) 1 NC_012468.1 identified by match to protein family HMM PF00230; glycerol facilitator-aquaporin gla (Aquaglyceroporin)(Glyceroaquaporin) 1410968 7683586 SP70585_1530 Streptococcus pneumoniae 70585 glycerol facilitator-aquaporin gla (Aquaglyceroporin)(Glyceroaquaporin) YP_002740760.1 1410099 R 488221 CDS YP_002740761.1 225859251 7684093 complement(1411191..1411712) 1 NC_012468.1 identified by match to protein family HMM PF00746; match to protein family HMM PF06458; match to protein family HMM TIGR01167; MucBP domain family 1411712 7684093 SP70585_1531 Streptococcus pneumoniae 70585 MucBP domain family YP_002740761.1 1411191 R 488221 CDS YP_002740762.1 225859252 7685116 complement(1411670..1412749) 1 NC_012468.1 hypothetical protein 1412749 7685116 SP70585_1532 Streptococcus pneumoniae 70585 hypothetical protein YP_002740762.1 1411670 R 488221 CDS YP_002740763.1 225859253 7684851 complement(1412860..1413114) 1 NC_012468.1 hypothetical protein 1413114 7684851 SP70585_1533 Streptococcus pneumoniae 70585 hypothetical protein YP_002740763.1 1412860 R 488221 CDS YP_002740764.1 225859254 7683743 complement(1413472..1414005) 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase 1414005 7683743 SP70585_1534 Streptococcus pneumoniae 70585 transposase YP_002740764.1 1413472 R 488221 CDS YP_002740765.1 225859255 7684412 complement(1413992..1414207) 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; hypothetical protein 1414207 7684412 SP70585_1535 Streptococcus pneumoniae 70585 hypothetical protein YP_002740765.1 1413992 R 488221 CDS YP_002740766.1 225859256 7683612 1414551..1416269 1 NC_012468.1 identified by match to protein family HMM PF00408; match to protein family HMM PF02878; match to protein family HMM PF02879; match to protein family HMM PF02880; phosphomannomutase 1416269 7683612 SP70585_1536 Streptococcus pneumoniae 70585 phosphomannomutase YP_002740766.1 1414551 D 488221 CDS YP_002740767.1 225859257 7684013 1416380..1416727 1 NC_012468.1 identified by match to protein family HMM TIGR01295; bacterocin transport accessory protein 1416727 7684013 SP70585_1537 Streptococcus pneumoniae 70585 bacterocin transport accessory protein YP_002740767.1 1416380 D 488221 CDS YP_002740768.1 225859258 7683045 complement(1417005..1417841) 1 NC_012468.1 identified by match to protein family HMM PF00497; ABC transporter substrate-binding protein - glutamine transport 1417841 7683045 SP70585_1538 Streptococcus pneumoniae 70585 ABC transporter substrate-binding protein - glutamine transport YP_002740768.1 1417005 R 488221 CDS YP_002740769.1 225859259 7684831 complement(1417854..1418483) 1 NC_012468.1 identified by match to protein family HMM PF00005; glutamine transport ATP-binding protein GlnQ 1418483 7684831 SP70585_1539 Streptococcus pneumoniae 70585 glutamine transport ATP-binding protein GlnQ YP_002740769.1 1417854 R 488221 CDS YP_002740770.1 225859260 7684522 complement(1418493..1419134) 1 NC_012468.1 identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; amino acid ABC transporter permease 1419134 7684522 SP70585_1540 Streptococcus pneumoniae 70585 amino acid ABC transporter permease YP_002740770.1 1418493 R 488221 CDS YP_002740771.1 225859261 7683379 complement(1419280..1420509) 1 NC_012468.1 identified by match to protein family HMM PF00515; match to protein family HMM PF07719; TPR domain protein 1420509 7683379 SP70585_1541 Streptococcus pneumoniae 70585 TPR domain protein YP_002740771.1 1419280 R 488221 CDS YP_002740772.1 225859262 7683058 complement(1420499..1421665) 1 NC_012468.1 identified by match to protein family HMM PF01594; transport protein 1421665 7683058 SP70585_1542 Streptococcus pneumoniae 70585 transport protein YP_002740772.1 1420499 R 488221 CDS YP_002740773.1 225859263 7684495 1421809..1422822 1 NC_012468.1 3-carboxymuconate cyclase 1422822 7684495 SP70585_1543 Streptococcus pneumoniae 70585 3-carboxymuconate cyclase YP_002740773.1 1421809 D 488221 CDS YP_002740774.1 225859264 7685179 complement(1422867..1423286) 1 NC_012468.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; F0F1 ATP synthase subunit epsilon 1423286 atpC 7685179 atpC Streptococcus pneumoniae 70585 F0F1 ATP synthase subunit epsilon YP_002740774.1 1422867 R 488221 CDS YP_002740775.1 225859265 7685009 complement(1423297..1424703) 1 NC_012468.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; F0F1 ATP synthase subunit beta 1424703 atpD 7685009 atpD Streptococcus pneumoniae 70585 F0F1 ATP synthase subunit beta YP_002740775.1 1423297 R 488221 CDS YP_002740776.1 225859266 7684362 complement(1424789..1425667) 1 NC_012468.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; F0F1 ATP synthase subunit gamma 1425667 atpG 7684362 atpG Streptococcus pneumoniae 70585 F0F1 ATP synthase subunit gamma YP_002740776.1 1424789 R 488221 CDS YP_002740777.1 225859267 7684003 complement(1425683..1427188) 1 NC_012468.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; F0F1 ATP synthase subunit alpha 1427188 atpA 7684003 atpA Streptococcus pneumoniae 70585 F0F1 ATP synthase subunit alpha YP_002740777.1 1425683 R 488221 CDS YP_002740778.1 225859268 7683331 complement(1427203..1427739) 1 NC_012468.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit delta 1427739 atpH 7683331 atpH Streptococcus pneumoniae 70585 F0F1 ATP synthase subunit delta YP_002740778.1 1427203 R 488221 CDS YP_002740779.1 225859269 7684194 complement(1427739..1428233) 1 NC_012468.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; F0F1 ATP synthase subunit B 1428233 atpF 7684194 atpF Streptococcus pneumoniae 70585 F0F1 ATP synthase subunit B YP_002740779.1 1427739 R 488221 CDS YP_002740780.1 225859270 7684023 complement(1428247..1428963) 1 NC_012468.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; F0F1 ATP synthase subunit A 1428963 atpB 7684023 atpB Streptococcus pneumoniae 70585 F0F1 ATP synthase subunit A YP_002740780.1 1428247 R 488221 CDS YP_002740781.1 225859271 7683884 complement(1428998..1429198) 1 NC_012468.1 produces ATP from ADP in the presence of a proton gradient across the membrane; subunit C is part of the membrane proton channel F0; F0F1 ATP synthase subunit C 1429198 7683884 SP70585_1551 Streptococcus pneumoniae 70585 F0F1 ATP synthase subunit C YP_002740781.1 1428998 R 488221 CDS YP_002740782.1 225859272 7683647 complement(1430694..1430936) 1 NC_012468.1 acetyltransferase, gnat family protein 1430936 7683647 SP70585_1554 Streptococcus pneumoniae 70585 acetyltransferase, gnat family protein YP_002740782.1 1430694 R 488221 CDS YP_002740783.1 225859273 7684352 1431064..1431612 1 NC_012468.1 hypothetical protein 1431612 7684352 SP70585_1555 Streptococcus pneumoniae 70585 hypothetical protein YP_002740783.1 1431064 D 488221 CDS YP_002740784.1 225859274 7684938 complement(1431669..1432151) 1 NC_012468.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA 1432151 greA 7684938 greA Streptococcus pneumoniae 70585 transcription elongation factor GreA YP_002740784.1 1431669 R 488221 CDS YP_002740785.1 225859275 7684161 complement(1432222..1433877) 1 NC_012468.1 identified by match to protein family HMM PF02618; match to protein family HMM TIGR00247; aminodeoxychorismate lyase 1433877 7684161 SP70585_1557 Streptococcus pneumoniae 70585 aminodeoxychorismate lyase YP_002740785.1 1432222 R 488221 CDS YP_002740786.1 225859276 7683245 complement(1433958..1434452) 1 NC_012468.1 identified by match to protein family HMM PF00583; acetyltransferase, gnat family 1434452 7683245 SP70585_1558 Streptococcus pneumoniae 70585 acetyltransferase, gnat family YP_002740786.1 1433958 R 488221 CDS YP_002740787.1 225859277 7684248 complement(1434449..1434913) 1 NC_012468.1 identified by match to protein family HMM PF00583; acetyltransferase, gnat family 1434913 7684248 SP70585_1559 Streptococcus pneumoniae 70585 acetyltransferase, gnat family YP_002740787.1 1434449 R 488221 CDS YP_002740788.1 225859278 7684733 complement(1434923..1436257) 1 NC_012468.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 1436257 murC 7684733 murC Streptococcus pneumoniae 70585 UDP-N-acetylmuramate--L-alanine ligase YP_002740788.1 1434923 R 488221 CDS YP_002740789.1 225859279 7683557 complement(1436268..1436885) 1 NC_012468.1 hypothetical protein 1436885 7683557 SP70585_1561 Streptococcus pneumoniae 70585 hypothetical protein YP_002740789.1 1436268 R 488221 CDS YP_002740790.1 225859280 7683693 complement(1436933..1440031) 1 NC_012468.1 identified by match to protein family HMM PF00176; match to protein family HMM PF00271; match to protein family HMM PF04434; match to protein family HMM PF08455; Snf2 family protein 1440031 7683693 SP70585_1562 Streptococcus pneumoniae 70585 Snf2 family protein YP_002740790.1 1436933 R 488221 CDS YP_002740791.1 225859281 7683170 complement(1440124..1441290) 1 NC_012468.1 identified by match to protein family HMM PF00155; putative aminotransferase B 1441290 7683170 SP70585_1563 Streptococcus pneumoniae 70585 putative aminotransferase B YP_002740791.1 1440124 R 488221 CDS YP_002740792.1 225859282 7684047 complement(1441298..1442392) 1 NC_012468.1 catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; cystathionine gamma-synthase 1442392 7684047 SP70585_1564 Streptococcus pneumoniae 70585 cystathionine gamma-synthase YP_002740792.1 1441298 R 488221 CDS YP_002740793.1 225859283 7684320 complement(1444397..1446355) 1 NC_012468.1 identified by match to protein family HMM PF00496; oligopeptide binding lipoprotein 1446355 7684320 SP70585_1567 Streptococcus pneumoniae 70585 oligopeptide binding lipoprotein YP_002740793.1 1444397 R 488221 CDS YP_002740794.1 225859284 7682915 complement(1446558..1448180) 1 NC_012468.1 identified by match to protein family HMM PF01943; match to protein family HMM PF03023; polysaccharide transporter 1448180 7682915 SP70585_1568 Streptococcus pneumoniae 70585 polysaccharide transporter YP_002740794.1 1446558 R 488221 CDS YP_002740795.1 225859285 7684391 1448286..1449731 1 NC_012468.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of lysine to UDP-N-acetylmuramoyl-L-alanyl-D-glutamate forming UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine; UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase 1449731 7684391 SP70585_1569 Streptococcus pneumoniae 70585 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase YP_002740795.1 1448286 D 488221 CDS YP_002740796.1 225859286 7684765 complement(1449774..1449971) 1 NC_012468.1 identified by match to protein family HMM PF05532; hypothetical protein 1449971 7684765 SP70585_1570 Streptococcus pneumoniae 70585 hypothetical protein YP_002740796.1 1449774 R 488221 CDS YP_002740797.1 225859287 7683031 complement(1450072..1450668) 1 NC_012468.1 identified by match to protein family HMM PF08820; hypothetical protein 1450668 7683031 SP70585_1571 Streptococcus pneumoniae 70585 hypothetical protein YP_002740797.1 1450072 R 488221 CDS YP_002740798.1 225859288 7684923 complement(1450705..1451217) 1 NC_012468.1 hypothetical protein 1451217 7684923 SP70585_1572 Streptococcus pneumoniae 70585 hypothetical protein YP_002740798.1 1450705 R 488221 CDS YP_002740799.1 225859289 7684824 complement(1451304..1452239) 1 NC_012468.1 catalyzes the hydrolysis of pyrophosphate to phosphate; putative manganese-dependent inorganic pyrophosphatase 1452239 7684824 SP70585_1573 Streptococcus pneumoniae 70585 putative manganese-dependent inorganic pyrophosphatase YP_002740799.1 1451304 R 488221 CDS YP_002740800.1 225859290 7684820 complement(1452310..1452609) 1 NC_012468.1 identified by match to protein family HMM PF01541; hypothetical protein 1452609 7684820 SP70585_1574 Streptococcus pneumoniae 70585 hypothetical protein YP_002740800.1 1452310 R 488221 CDS YP_002740801.1 225859291 7684689 complement(1452599..1453348) 1 NC_012468.1 identified by match to protein family HMM PF05175; methyltransferase 1453348 7684689 SP70585_1575 Streptococcus pneumoniae 70585 methyltransferase YP_002740801.1 1452599 R 488221 CDS YP_002740802.1 225859292 7684378 complement(1453402..1453788) 1 NC_012468.1 identified by match to protein family HMM PF00575; hypothetical protein 1453788 7684378 SP70585_1576 Streptococcus pneumoniae 70585 hypothetical protein YP_002740802.1 1453402 R 488221 CDS YP_002740803.1 225859293 7685104 complement(1453763..1455163) 1 NC_012468.1 identified by match to protein family HMM PF00160; match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; Cof family protein/peptidyl-prolyl cis-trans isomerase, cyclophilin type 1455163 7685104 SP70585_1577 Streptococcus pneumoniae 70585 Cof family protein/peptidyl-prolyl cis-trans isomerase, cyclophilin type YP_002740803.1 1453763 R 488221 CDS YP_002740804.1 225859294 7684611 complement(1455458..1455697) 1 NC_012468.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 1455697 rpsR 7684611 rpsR Streptococcus pneumoniae 70585 30S ribosomal protein S18 YP_002740804.1 1455458 R 488221 CDS YP_002740805.1 225859295 7684888 complement(1455729..1456199) 1 NC_012468.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein 1456199 7684888 SP70585_1579 Streptococcus pneumoniae 70585 single-stranded DNA-binding protein YP_002740805.1 1455729 R 488221 CDS YP_002740806.1 225859296 7682940 complement(1456211..1456501) 1 NC_012468.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 1456501 rpsF 7682940 rpsF Streptococcus pneumoniae 70585 30S ribosomal protein S6 YP_002740806.1 1456211 R 488221 CDS YP_002740807.1 225859297 7684116 complement(1456654..1457997) 1 NC_012468.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; asparaginyl-tRNA synthetase 1457997 asnC 7684116 asnC Streptococcus pneumoniae 70585 asparaginyl-tRNA synthetase YP_002740807.1 1456654 R 488221 CDS YP_002740808.1 225859298 7683494 complement(1458016..1458381) 1 NC_012468.1 identified by match to protein family HMM PF00903; glyoxalase family protein 1458381 7683494 SP70585_1582 Streptococcus pneumoniae 70585 glyoxalase family protein YP_002740808.1 1458016 R 488221 CDS YP_002740809.1 225859299 7684338 complement(1458374..1459561) 1 NC_012468.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; aspartate aminotransferase 1459561 7684338 SP70585_1583 Streptococcus pneumoniae 70585 aspartate aminotransferase YP_002740809.1 1458374 R 488221 CDS YP_002740810.1 225859300 7684876 complement(1459558..1460046) 1 NC_012468.1 identified by match to protein family HMM PF03413; peptidase propeptide and ypeb domain protein 1460046 7684876 SP70585_1584 Streptococcus pneumoniae 70585 peptidase propeptide and ypeb domain protein YP_002740810.1 1459558 R 488221 CDS YP_002740811.1 225859301 7684481 complement(1460113..1460229) 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 1460229 7684481 SP70585_1585 Streptococcus pneumoniae 70585 hypothetical protein YP_002740811.1 1460113 R 488221 CDS YP_002740812.1 225859302 7684151 1460367..1460915 1 NC_012468.1 identified by match to protein family HMM PF02525; match to protein family HMM PF03358; oxidoreductase 1460915 7684151 SP70585_1586 Streptococcus pneumoniae 70585 oxidoreductase YP_002740812.1 1460367 D 488221 CDS YP_002740813.1 225859303 7683966 complement(1461152..1467109) 1 NC_012468.1 identified by match to protein family HMM PF01391; match to protein family HMM PF04650; match to protein family HMM PF07501; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; G5 domain family 1467109 7683966 SP70585_1587 Streptococcus pneumoniae 70585 G5 domain family YP_002740813.1 1461152 R 488221 CDS YP_002740814.1 225859304 7683281 1467325..1468809 1 NC_012468.1 identified by match to protein family HMM PF05043; match to protein family HMM PF08270; match to protein family HMM PF08279; match to protein family HMM PF08280; M protein trans-acting positive transcriptional regulator 1468809 7683281 SP70585_1588 Streptococcus pneumoniae 70585 M protein trans-acting positive transcriptional regulator YP_002740814.1 1467325 D 488221 CDS YP_002740815.1 225859305 7683574 complement(1468860..1469588) 1 NC_012468.1 identified by match to protein family HMM PF03883; hypothetical protein 1469588 7683574 SP70585_1589 Streptococcus pneumoniae 70585 hypothetical protein YP_002740815.1 1468860 R 488221 CDS YP_002740816.1 225859306 7684423 complement(1469667..1469831) 1 NC_012468.1 hypothetical protein 1469831 7684423 SP70585_1590 Streptococcus pneumoniae 70585 hypothetical protein YP_002740816.1 1469667 R 488221 CDS YP_002740817.1 225859307 7684259 complement(1469998..1471593) 1 NC_012468.1 hypothetical protein 1471593 7684259 SP70585_1591 Streptococcus pneumoniae 70585 hypothetical protein YP_002740817.1 1469998 R 488221 CDS YP_002740818.1 225859308 7684801 complement(1471605..1472015) 1 NC_012468.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 1472015 def2 7684801 def2 Streptococcus pneumoniae 70585 peptide deformylase YP_002740818.1 1471605 R 488221 CDS YP_002740819.1 225859309 7684542 complement(1472131..1472922) 1 NC_012468.1 YghU; B2989; one of eight putative glutathione transferases from E. coli; putative glutathione S-transferase YghU 1472922 7684542 SP70585_1593 Streptococcus pneumoniae 70585 putative glutathione S-transferase YghU YP_002740819.1 1472131 R 488221 CDS YP_002740820.1 225859310 7684940 complement(1472935..1475631) 1 NC_012468.1 identified by match to protein family HMM PF00122; match to protein family HMM PF00689; match to protein family HMM PF00690; match to protein family HMM PF00702; match to protein family HMM TIGR01494; calcium-transporting ATPase 1 1475631 7684940 SP70585_1594 Streptococcus pneumoniae 70585 calcium-transporting ATPase 1 YP_002740820.1 1472935 R 488221 CDS YP_002740821.1 225859311 7683714 1475935..1477119 1 NC_012468.1 identified by match to protein family HMM PF01545; match to protein family HMM TIGR01297; cation efflux family protein 1477119 7683714 SP70585_1595 Streptococcus pneumoniae 70585 cation efflux family protein YP_002740821.1 1475935 D 488221 CDS YP_002740822.1 225859312 7683666 complement(1477262..1479133) 1 NC_012468.1 identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1479133 7683666 SP70585_1596 Streptococcus pneumoniae 70585 ABC transporter ATP-binding protein YP_002740822.1 1477262 R 488221 CDS YP_002740823.1 225859313 7682981 complement(1479130..1480314) 1 NC_012468.1 catalyzes the addition and repair of the 3'-terminal CCA sequence in tRNA; these proteins belong to the CCA-adding enzyme subfamily 2 which does not have phosphohydrolase activity; tRNA CCA-pyrophosphorylase 1480314 7682981 SP70585_1597 Streptococcus pneumoniae 70585 tRNA CCA-pyrophosphorylase YP_002740823.1 1479130 R 488221 CDS YP_002740824.1 225859314 7683125 complement(1480326..1481093) 1 NC_012468.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase 1481093 dapB 7683125 dapB Streptococcus pneumoniae 70585 dihydrodipicolinate reductase YP_002740824.1 1480326 R 488221 CDS YP_002740825.1 225859315 7684139 complement(1481359..1482207) 1 NC_012468.1 identified by match to protein family HMM PF02645; match to protein family HMM TIGR00762; hypothetical protein 1482207 7684139 SP70585_1599 Streptococcus pneumoniae 70585 hypothetical protein YP_002740825.1 1481359 R 488221 CDS YP_002740826.1 225859316 7683978 complement(1482209..1482583) 1 NC_012468.1 identified by match to protein family HMM PF06619; hypothetical protein 1482583 7683978 SP70585_1600 Streptococcus pneumoniae 70585 hypothetical protein YP_002740826.1 1482209 R 488221 CDS YP_002740827.1 225859317 7684353 complement(1482657..1484009) 1 NC_012468.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase 1484009 glmM 7684353 glmM Streptococcus pneumoniae 70585 phosphoglucosamine mutase YP_002740827.1 1482657 R 488221 CDS YP_002740828.1 225859318 7682903 complement(1484033..1484812) 1 NC_012468.1 identified by match to protein family HMM PF07949; lipoprotein, putative 1484812 7682903 SP70585_1602 Streptococcus pneumoniae 70585 lipoprotein, putative YP_002740828.1 1484033 R 488221 CDS YP_002740829.1 225859319 7683657 complement(1484799..1485656) 1 NC_012468.1 identified by match to protein family HMM PF02457; match to protein family HMM TIGR00159; hypothetical protein 1485656 7683657 SP70585_1603 Streptococcus pneumoniae 70585 hypothetical protein YP_002740829.1 1484799 R 488221 CDS YP_002740830.1 225859320 7683029 1485792..1486757 1 NC_012468.1 identified by match to protein family HMM PF00070; match to protein family HMM PF07992; pyridine nucleotide-disulfide oxidoreductase family protein 1486757 7683029 SP70585_1604 Streptococcus pneumoniae 70585 pyridine nucleotide-disulfide oxidoreductase family protein YP_002740830.1 1485792 D 488221 CDS YP_002740831.1 225859321 7684704 complement(1486791..1487702) 1 NC_012468.1 identified by match to protein family HMM PF02650; match to protein family HMM TIGR00647; hypothetical protein 1487702 7684704 SP70585_1605 Streptococcus pneumoniae 70585 hypothetical protein YP_002740831.1 1486791 R 488221 CDS YP_002740832.1 225859322 7684978 complement(1487699..1488676) 1 NC_012468.1 identified by match to protein family HMM PF01933; match to protein family HMM TIGR01826; transporter 1488676 7684978 SP70585_1606 Streptococcus pneumoniae 70585 transporter YP_002740832.1 1487699 R 488221 CDS YP_002740833.1 225859323 7683149 complement(1488673..1489563) 1 NC_012468.1 identified by match to protein family HMM PF03668; hypothetical protein 1489563 7683149 SP70585_1607 Streptococcus pneumoniae 70585 hypothetical protein YP_002740833.1 1488673 R 488221 CDS YP_002740834.1 225859324 7684430 complement(1489615..1489995) 1 NC_012468.1 identified by match to protein family HMM PF01042; match to protein family HMM TIGR00004; endoribonuclease L-PSP, putative 1489995 7684430 SP70585_1608 Streptococcus pneumoniae 70585 endoribonuclease L-PSP, putative YP_002740834.1 1489615 R 488221 CDS YP_002740835.1 225859325 7683776 complement(1490006..1490593) 1 NC_012468.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC 1490593 engB 7683776 engB Streptococcus pneumoniae 70585 ribosome biogenesis GTP-binding protein YsxC YP_002740835.1 1490006 R 488221 CDS YP_002740836.1 225859326 7683433 complement(1490602..1491834) 1 NC_012468.1 binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 1491834 clpX 7683433 clpX Streptococcus pneumoniae 70585 ATP-dependent protease ATP-binding subunit ClpX YP_002740836.1 1490602 R 488221 CDS YP_002740837.1 225859327 7683707 complement(1491866..1492036) 1 NC_012468.1 hypothetical protein 1492036 7683707 SP70585_1611 Streptococcus pneumoniae 70585 hypothetical protein YP_002740837.1 1491866 R 488221 CDS YP_002740838.1 225859328 7684873 complement(1492036..1492542) 1 NC_012468.1 identified by match to protein family HMM PF00186; dihydrofolate reductase 1492542 folA 7684873 folA Streptococcus pneumoniae 70585 dihydrofolate reductase YP_002740838.1 1492036 R 488221 CDS YP_002740839.1 225859329 7684246 complement(1492672..1493190) 1 NC_012468.1 identified by match to protein family HMM PF00210; DNA protection during starvation protein 1493190 7684246 SP70585_1613 Streptococcus pneumoniae 70585 DNA protection during starvation protein YP_002740839.1 1492672 R 488221 CDS YP_002740840.1 225859330 7683560 complement(1493686..1495158) 1 NC_012468.1 identified by match to protein family HMM PF01183; match to protein family HMM PF01473; 1,4-beta-N-acetylmuramidase 1495158 7683560 SP70585_1614 Streptococcus pneumoniae 70585 1,4-beta-N-acetylmuramidase YP_002740840.1 1493686 R 488221 CDS YP_002740841.1 225859331 7683174 complement(1495229..1495987) 1 NC_012468.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 1495987 tpiA 7683174 tpiA Streptococcus pneumoniae 70585 triosephosphate isomerase YP_002740841.1 1495229 R 488221 CDS YP_002740842.1 225859332 7684918 complement(1496085..1496762) 1 NC_012468.1 identified by match to protein family HMM PF04271; match to protein family HMM TIGR01446; DNA replication protein DnaD 1496762 7684918 SP70585_1616 Streptococcus pneumoniae 70585 DNA replication protein DnaD YP_002740842.1 1496085 R 488221 CDS YP_002740843.1 225859333 7684782 complement(1496771..1497715) 1 NC_012468.1 catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis; homoserine O-succinyltransferase 1497715 metA 7684782 metA Streptococcus pneumoniae 70585 homoserine O-succinyltransferase YP_002740843.1 1496771 R 488221 CDS YP_002740844.1 225859334 7683205 complement(1497897..1498409) 1 NC_012468.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 1498409 apt 7683205 apt Streptococcus pneumoniae 70585 adenine phosphoribosyltransferase YP_002740844.1 1497897 R 488221 CDS YP_002740845.1 225859335 7684753 complement(1498496..1499254) 1 NC_012468.1 identified by match to protein family HMM PF08241; match to protein family HMM PF08242; SAM-dependent methyltransferase 1499254 7684753 SP70585_1619 Streptococcus pneumoniae 70585 SAM-dependent methyltransferase YP_002740845.1 1498496 R 488221 CDS YP_002740846.1 225859336 7683608 complement(1499755..1500885) 1 NC_012468.1 identified by match to protein family HMM PF00005; match to protein family HMM PF03459; match to protein family HMM PF08402; multiple sugar-binding transport ATP-binding protein MsmK 1500885 7683608 SP70585_1620 Streptococcus pneumoniae 70585 multiple sugar-binding transport ATP-binding protein MsmK YP_002740846.1 1499755 R 488221 CDS YP_002740847.1 225859337 7683180 1500986..1501108 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 1501108 7683180 SP70585_1621 Streptococcus pneumoniae 70585 hypothetical protein YP_002740847.1 1500986 D 488221 CDS YP_002740848.1 225859338 7684316 complement(1501335..1501910) 1 NC_012468.1 identified by match to protein family HMM PF00857; isochorismatase 1501910 7684316 SP70585_1623 Streptococcus pneumoniae 70585 isochorismatase YP_002740848.1 1501335 R 488221 CDS YP_002740849.1 225859339 7683683 complement(1501910..1502698) 1 NC_012468.1 CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase (By similarity). It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; transcriptional repressor CodY 1502698 codY 7683683 codY Streptococcus pneumoniae 70585 transcriptional repressor CodY YP_002740849.1 1501910 R 488221 CDS YP_002740850.1 225859340 7682926 complement(1502962..1504536) 1 NC_012468.1 identified by match to protein family HMM PF00270; match to protein family HMM PF00271; cold-shock DEAD box protein A 1504536 7682926 SP70585_1625 Streptococcus pneumoniae 70585 cold-shock DEAD box protein A YP_002740850.1 1502962 R 488221 CDS YP_002740851.1 225859341 7684979 complement(1504735..1505019) 1 NC_012468.1 major facilitator:Oxalate:Formate Antiporter 1505019 7684979 SP70585_1626 Streptococcus pneumoniae 70585 major facilitator:Oxalate:Formate Antiporter YP_002740851.1 1504735 R 488221 CDS YP_002740852.1 225859342 7684511 complement(1505113..1505490) 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01609; transposase (IS4 family) 1505490 7684511 SP70585_1627 Streptococcus pneumoniae 70585 transposase (IS4 family) YP_002740852.1 1505113 R 488221 CDS YP_002740853.1 225859343 7684437 complement(1505502..1505963) 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase 1505963 7684437 SP70585_1628 Streptococcus pneumoniae 70585 transposase YP_002740853.1 1505502 R 488221 CDS YP_002740854.1 225859344 7684213 complement(1505953..1506834) 1 NC_012468.1 identified by match to protein family HMM PF07690; oxalate:formate antiporter 1506834 7684213 SP70585_1629 Streptococcus pneumoniae 70585 oxalate:formate antiporter YP_002740854.1 1505953 R 488221 CDS YP_002740855.1 225859345 7684885 1507027..1508343 1 NC_012468.1 Involved in disulfide oxidoreductase activity and electron transport; pyridine nucleotide-disulfide oxidoreductase 1508343 7684885 SP70585_1630 Streptococcus pneumoniae 70585 pyridine nucleotide-disulfide oxidoreductase YP_002740855.1 1507027 D 488221 CDS YP_002740856.1 225859346 7684271 1508442..1509785 1 NC_012468.1 identified by match to protein family HMM PF08245; match to protein family HMM PF08353; Mur ligase family protein 1509785 7684271 SP70585_1631 Streptococcus pneumoniae 70585 Mur ligase family protein YP_002740856.1 1508442 D 488221 CDS YP_002740857.1 225859347 7683412 1509785..1510567 1 NC_012468.1 identified by match to protein family HMM PF07685; cobyric acid synthase 1510567 7683412 SP70585_1632 Streptococcus pneumoniae 70585 cobyric acid synthase YP_002740857.1 1509785 D 488221 CDS YP_002740858.1 225859348 7683185 1510693..1511775 1 NC_012468.1 identified by match to protein family HMM PF00557; match to protein family HMM PF01321; Xaa-Pro dipeptidase (X-Pro dipeptidase) (Prolinedipeptidase) (Prolidase) (Imidodipeptidase) 1511775 7683185 SP70585_1633 Streptococcus pneumoniae 70585 Xaa-Pro dipeptidase (X-Pro dipeptidase) (Prolinedipeptidase) (Prolidase) (Imidodipeptidase) YP_002740858.1 1510693 D 488221 CDS YP_002740859.1 225859349 7683976 complement(1512099..1512932) 1 NC_012468.1 identified by match to protein family HMM PF00665; integrase core domain protein 1512932 7683976 SP70585_1634 Streptococcus pneumoniae 70585 integrase core domain protein YP_002740859.1 1512099 R 488221 CDS YP_002740860.1 225859350 7683848 complement(1513158..1513370) 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase 1513370 7683848 SP70585_1635 Streptococcus pneumoniae 70585 transposase YP_002740860.1 1513158 R 488221 CDS YP_002740861.1 225859351 7683306 complement(1513624..1514085) 1 NC_012468.1 hypothetical protein 1514085 7683306 SP70585_1636 Streptococcus pneumoniae 70585 hypothetical protein YP_002740861.1 1513624 R 488221 CDS YP_002740862.1 225859352 7683422 complement(1514082..1514837) 1 NC_012468.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase 1514837 7683422 SP70585_1637 Streptococcus pneumoniae 70585 phosphomethylpyrimidine kinase YP_002740862.1 1514082 R 488221 CDS YP_002740863.1 225859353 7683853 complement(1514827..1515576) 1 NC_012468.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A 1515576 truA 7683853 truA Streptococcus pneumoniae 70585 tRNA pseudouridine synthase A YP_002740863.1 1514827 R 488221 CDS YP_002740864.1 225859354 7684784 complement(1515893..1517044) 1 NC_012468.1 identified by match to protein family HMM PF07690; major facilitator superfamily transporter 1517044 7684784 SP70585_1639 Streptococcus pneumoniae 70585 major facilitator superfamily transporter YP_002740864.1 1515893 R 488221 CDS YP_002740865.1 225859355 7684625 1517016..1517132 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 1517132 7684625 SP70585_1640 Streptococcus pneumoniae 70585 hypothetical protein YP_002740865.1 1517016 D 488221 CDS YP_002740866.1 225859356 7683994 complement(1517284..1517913) 1 NC_012468.1 hypothetical protein 1517913 7683994 SP70585_1641 Streptococcus pneumoniae 70585 hypothetical protein YP_002740866.1 1517284 R 488221 CDS YP_002740867.1 225859357 7683260 complement(1517916..1518254) 1 NC_012468.1 identified by match to protein family HMM PF03831; match to protein family HMM PF08274; match to protein family HMM TIGR00686; alkylphosphonate utilization operon protein PhnA 1518254 phnA 7683260 phnA Streptococcus pneumoniae 70585 alkylphosphonate utilization operon protein PhnA YP_002740867.1 1517916 R 488221 CDS YP_002740868.1 225859358 7684371 complement(1518384..1519055) 1 NC_012468.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 1519055 cmk 7684371 cmk Streptococcus pneumoniae 70585 cytidylate kinase YP_002740868.1 1518384 R 488221 CDS YP_002740869.1 225859359 7682944 complement(1519064..1519540) 1 NC_012468.1 hypothetical protein 1519540 7682944 SP70585_1644 Streptococcus pneumoniae 70585 hypothetical protein YP_002740869.1 1519064 R 488221 CDS YP_002740870.1 225859360 7683051 1519682..1519798 1 NC_012468.1 ferredoxin 1519798 7683051 SP70585_1645 Streptococcus pneumoniae 70585 ferredoxin YP_002740870.1 1519682 D 488221 CDS YP_002740871.1 225859361 7682964 complement(1519849..1520814) 1 NC_012468.1 identified by match to protein family HMM PF00535; bactoprenol glucosyl transferase 1520814 7682964 SP70585_1646 Streptococcus pneumoniae 70585 bactoprenol glucosyl transferase YP_002740871.1 1519849 R 488221 CDS YP_002740872.1 225859362 7684655 complement(1520816..1521835) 1 NC_012468.1 identified by match to protein family HMM PF00106; match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF04321; match to protein family HMM PF07993; match to protein family HMM TIGR01179; UDP-glucose 4-epimerase 1521835 galE 7684655 galE Streptococcus pneumoniae 70585 UDP-glucose 4-epimerase YP_002740872.1 1520816 R 488221 CDS YP_002740873.1 225859363 7683108 complement(1521938..1522129) 1 NC_012468.1 chlorohydrolase 1522129 7683108 SP70585_1648 Streptococcus pneumoniae 70585 chlorohydrolase YP_002740873.1 1521938 R 488221 CDS YP_002740874.1 225859364 7683293 complement(1522136..1523239) 1 NC_012468.1 identified by match to protein family HMM PF01266; oxidoreductase, DadA family protein 1523239 7683293 SP70585_1649 Streptococcus pneumoniae 70585 oxidoreductase, DadA family protein YP_002740874.1 1522136 R 488221 CDS YP_002740875.1 225859365 7684349 complement(1523256..1524053) 1 NC_012468.1 identified by match to protein family HMM PF01784; match to protein family HMM TIGR00486; hypothetical protein 1524053 7684349 SP70585_1650 Streptococcus pneumoniae 70585 hypothetical protein YP_002740875.1 1523256 R 488221 CDS YP_002740876.1 225859366 7683959 complement(1524040..1524717) 1 NC_012468.1 identified by match to protein family HMM PF04816; Bcl-2 family protein 1524717 7683959 SP70585_1651 Streptococcus pneumoniae 70585 Bcl-2 family protein YP_002740876.1 1524040 R 488221 CDS YP_002740877.1 225859367 7684660 1525266..1526216 1 NC_012468.1 hypothetical protein 1526216 7684660 SP70585_1652 Streptococcus pneumoniae 70585 hypothetical protein YP_002740877.1 1525266 D 488221 CDS YP_002740878.1 225859368 7684976 complement(1526333..1526821) 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF00665; integrase core domain, putative 1526821 7684976 SP70585_1653 Streptococcus pneumoniae 70585 integrase core domain, putative YP_002740878.1 1526333 R 488221 CDS YP_002740879.1 225859369 7683028 complement(1526883..1527155) 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; hypothetical protein 1527155 7683028 SP70585_1654 Streptococcus pneumoniae 70585 hypothetical protein YP_002740879.1 1526883 R 488221 CDS YP_002740880.1 225859370 7683143 complement(1527155..1527322) 1 NC_012468.1 transposase 1527322 7683143 SP70585_1655 Streptococcus pneumoniae 70585 transposase YP_002740880.1 1527155 R 488221 CDS YP_002740881.1 225859371 7685070 complement(1527458..1527670) 1 NC_012468.1 transposase 1527670 7685070 SP70585_1656 Streptococcus pneumoniae 70585 transposase YP_002740881.1 1527458 R 488221 CDS YP_002740882.1 225859372 7683451 complement(1528040..1530010) 1 NC_012468.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 1530010 tkt1 7683451 tkt1 Streptococcus pneumoniae 70585 transketolase YP_002740882.1 1528040 R 488221 CDS YP_002740883.1 225859373 7684510 complement(1530047..1530742) 1 NC_012468.1 identified by match to protein family HMM PF00834; allulose-6-phosphate 3-epimerase 1530742 7684510 SP70585_1658 Streptococcus pneumoniae 70585 allulose-6-phosphate 3-epimerase YP_002740883.1 1530047 R 488221 CDS YP_002740884.1 225859374 7683400 complement(1530753..1531838) 1 NC_012468.1 identified by match to protein family HMM PF02378; match to protein family HMM TIGR01427; PTS system, IIC component 1531838 7683400 SP70585_1659 Streptococcus pneumoniae 70585 PTS system, IIC component YP_002740884.1 1530753 R 488221 CDS YP_002740885.1 225859375 7682955 complement(1531864..1532175) 1 NC_012468.1 identified by match to protein family HMM PF02379; match to protein family HMM TIGR00829; PTS system, IIB component 1532175 7682955 SP70585_1660 Streptococcus pneumoniae 70585 PTS system, IIB component YP_002740885.1 1531864 R 488221 CDS YP_002740886.1 225859376 7683864 complement(1532203..1532652) 1 NC_012468.1 identified by match to protein family HMM PF00359; match to protein family HMM TIGR00848; PTS system, IIA component 1532652 7683864 SP70585_1661 Streptococcus pneumoniae 70585 PTS system, IIA component YP_002740886.1 1532203 R 488221 CDS YP_002740887.1 225859377 7683957 complement(1532630..1533058) 1 NC_012468.1 identified by match to protein family HMM PF00359; PTS system, nitrogen regulatory component IIA, putative 1533058 7683957 SP70585_1662 Streptococcus pneumoniae 70585 PTS system, nitrogen regulatory component IIA, putative YP_002740887.1 1532630 R 488221 CDS YP_002740888.1 225859378 7683339 complement(1533051..1534514) 1 NC_012468.1 identified by match to protein family HMM PF00874; match to protein family HMM PF05043; match to protein family HMM PF08279; putative transcription antiterminator BglG family protein 1534514 7683339 SP70585_1663 Streptococcus pneumoniae 70585 putative transcription antiterminator BglG family protein YP_002740888.1 1533051 R 488221 CDS YP_002740889.1 225859379 7683886 complement(1535043..1537379) 1 NC_012468.1 identified by match to protein family HMM PF00122; match to protein family HMM PF00702; match to protein family HMM TIGR01494; P-type ATPase - metal cation transport 1537379 7683886 SP70585_1664 Streptococcus pneumoniae 70585 P-type ATPase - metal cation transport YP_002740889.1 1535043 R 488221 CDS YP_002740890.1 225859380 7684347 1537512..1538261 1 NC_012468.1 identified by match to protein family HMM PF01553; acyltransferase family protein 1538261 7684347 SP70585_1665 Streptococcus pneumoniae 70585 acyltransferase family protein YP_002740890.1 1537512 D 488221 CDS YP_002740891.1 225859381 7684472 complement(1538552..1539166) 1 NC_012468.1 identified by match to protein family HMM PF03596; match to protein family HMM TIGR00779; CadD 1539166 7684472 SP70585_1666 Streptococcus pneumoniae 70585 CadD YP_002740891.1 1538552 R 488221 CDS YP_002740892.1 225859382 7684273 complement(1539980..1540249) 1 NC_012468.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 1540249 rpsO 7684273 rpsO Streptococcus pneumoniae 70585 30S ribosomal protein S15 YP_002740892.1 1539980 R 488221 CDS YP_002740893.1 225859383 7684368 complement(1540390..1541019) 1 NC_012468.1 YwnB 1541019 7684368 SP70585_1668 Streptococcus pneumoniae 70585 YwnB YP_002740893.1 1540390 R 488221 CDS YP_002740894.1 225859384 7684005 1541082..1541204 1 NC_012468.1 hypothetical protein 1541204 7684005 SP70585_1669 Streptococcus pneumoniae 70585 hypothetical protein YP_002740894.1 1541082 D 488221 CDS YP_002740895.1 225859385 7684340 1541889..1542029 1 NC_012468.1 hypothetical protein 1542029 7684340 SP70585_1670 Streptococcus pneumoniae 70585 hypothetical protein YP_002740895.1 1541889 D 488221 CDS YP_002740896.1 225859386 7684236 1542036..1542212 1 NC_012468.1 hypothetical protein 1542212 7684236 SP70585_1671 Streptococcus pneumoniae 70585 hypothetical protein YP_002740896.1 1542036 D 488221 CDS YP_002740897.1 225859387 7684138 1542270..1544213 1 NC_012468.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); threonyl-tRNA synthetase 1544213 thrS 7684138 thrS Streptococcus pneumoniae 70585 threonyl-tRNA synthetase YP_002740897.1 1542270 D 488221 CDS YP_002740898.1 225859388 7683621 complement(1544262..1545236) 1 NC_012468.1 identified by match to protein family HMM PF02518; histidine kinase 1545236 7683621 SP70585_1673 Streptococcus pneumoniae 70585 histidine kinase YP_002740898.1 1544262 R 488221 CDS YP_002740899.1 225859389 7684028 complement(1545229..1545906) 1 NC_012468.1 identified by match to protein family HMM PF00072; match to protein family HMM PF00486; response regulator 1545906 7684028 SP70585_1674 Streptococcus pneumoniae 70585 response regulator YP_002740899.1 1545229 R 488221 CDS YP_002740900.1 225859390 7684327 1546062..1547135 1 NC_012468.1 hypothetical protein 1547135 7684327 SP70585_1675 Streptococcus pneumoniae 70585 hypothetical protein YP_002740900.1 1546062 D 488221 CDS YP_002740901.1 225859391 7683752 complement(1547226..1547528) 1 NC_012468.1 hypothetical protein 1547528 7683752 SP70585_1676 Streptococcus pneumoniae 70585 hypothetical protein YP_002740901.1 1547226 R 488221 CDS YP_002740902.1 225859392 7684124 complement(1547597..1548034) 1 NC_012468.1 identified by match to protein family HMM PF02082; Rrf2 family protein 1548034 7684124 SP70585_1677 Streptococcus pneumoniae 70585 Rrf2 family protein YP_002740902.1 1547597 R 488221 CDS YP_002740903.1 225859393 7683721 complement(1548110..1548952) 1 NC_012468.1 identified by match to protein family HMM PF00149; metallophosphoesterase 1548952 7683721 SP70585_1678 Streptococcus pneumoniae 70585 metallophosphoesterase YP_002740903.1 1548110 R 488221 CDS YP_002740904.1 225859394 7684995 1549064..1549714 1 NC_012468.1 identified by match to protein family HMM PF01047; match to protein family HMM PF01325; match to protein family HMM PF02742; match to protein family HMM PF04023; iron-dependent transcriptional regulator 1549714 7684995 SP70585_1679 Streptococcus pneumoniae 70585 iron-dependent transcriptional regulator YP_002740904.1 1549064 D 488221 CDS YP_002740905.1 225859395 7684030 1549695..1549886 1 NC_012468.1 hypothetical protein 1549886 7684030 SP70585_1680 Streptococcus pneumoniae 70585 hypothetical protein YP_002740905.1 1549695 D 488221 CDS YP_002740906.1 225859396 7684672 1549912..1550559 1 NC_012468.1 hypothetical protein 1550559 7684672 SP70585_1681 Streptococcus pneumoniae 70585 hypothetical protein YP_002740906.1 1549912 D 488221 CDS YP_002740907.1 225859397 7683748 complement(1550594..1550713) 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 1550713 7683748 SP70585_1682 Streptococcus pneumoniae 70585 hypothetical protein YP_002740907.1 1550594 R 488221 CDS YP_002740908.1 225859398 7683219 1550690..1551103 1 NC_012468.1 hypothetical protein 1551103 7683219 SP70585_1683 Streptococcus pneumoniae 70585 hypothetical protein YP_002740908.1 1550690 D 488221 CDS YP_002740909.1 225859399 7683851 1551374..1551496 1 NC_012468.1 hypothetical protein 1551496 7683851 SP70585_1684 Streptococcus pneumoniae 70585 hypothetical protein YP_002740909.1 1551374 D 488221 CDS YP_002740910.1 225859400 7683358 complement(1551574..1552017) 1 NC_012468.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase 1552017 dtd 7683358 dtd Streptococcus pneumoniae 70585 D-tyrosyl-tRNA(Tyr) deacylase YP_002740910.1 1551574 R 488221 CDS YP_002740911.1 225859401 7683208 complement(1552047..1554269) 1 NC_012468.1 identified by match to protein family HMM PF01966; match to protein family HMM PF02824; match to protein family HMM PF04607; match to protein family HMM TIGR00691; guanosine-3,5-bis(diphosphate) 3-pyrophosphohydrolase 1554269 spoT 7683208 spoT Streptococcus pneumoniae 70585 guanosine-3,5-bis(diphosphate) 3-pyrophosphohydrolase YP_002740911.1 1552047 R 488221 CDS YP_002740912.1 225859402 7683983 1555263..1555892 1 NC_012468.1 identified by match to protein family HMM PF00753; metallo-beta-lactamase superfamily protein 1555892 7683983 SP70585_1687 Streptococcus pneumoniae 70585 metallo-beta-lactamase superfamily protein YP_002740912.1 1555263 D 488221 CDS YP_002740913.1 225859403 7682985 complement(1556014..1557906) 1 NC_012468.1 identified by match to protein family HMM PF01431; match to protein family HMM PF05649; endopeptidase O 1557906 7682985 SP70585_1688 Streptococcus pneumoniae 70585 endopeptidase O YP_002740913.1 1556014 R 488221 CDS YP_002740914.1 225859404 7683785 1558197..1558919 1 NC_012468.1 identified by match to protein family HMM PF00005; manganese transport system ATP-binding protein MntA 1558919 7683785 SP70585_1689 Streptococcus pneumoniae 70585 manganese transport system ATP-binding protein MntA YP_002740914.1 1558197 D 488221 CDS YP_002740915.1 225859405 7684137 1558916..1559764 1 NC_012468.1 identified by match to protein family HMM PF00950; manganese transport system membrane protein MntB 1559764 7684137 SP70585_1690 Streptococcus pneumoniae 70585 manganese transport system membrane protein MntB YP_002740915.1 1558916 D 488221 CDS YP_002740916.1 225859406 7684177 1559796..1560725 1 NC_012468.1 identified by match to protein family HMM PF01297; manganese ABC transporter substrate-binding lipoprotein (Adhesin B) (Saliva-binding protein) 1560725 7684177 SP70585_1691 Streptococcus pneumoniae 70585 manganese ABC transporter substrate-binding lipoprotein (Adhesin B) (Saliva-binding protein) YP_002740916.1 1559796 D 488221 CDS YP_002740917.1 225859407 7684084 1560848..1561339 1 NC_012468.1 antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase 1561339 tpx 7684084 tpx Streptococcus pneumoniae 70585 thiol peroxidase YP_002740917.1 1560848 D 488221 CDS YP_002740918.1 225859408 7684508 complement(1561435..1564143) 1 NC_012468.1 identified by match to protein family HMM PF02687; efflux ABC transporter permease 1564143 7684508 SP70585_1693 Streptococcus pneumoniae 70585 efflux ABC transporter permease YP_002740918.1 1561435 R 488221 CDS YP_002740919.1 225859409 7683504 complement(1564145..1564846) 1 NC_012468.1 identified by match to protein family HMM PF00005; macrolide export ATP-binding/permease MacB 1564846 7683504 SP70585_1694 Streptococcus pneumoniae 70585 macrolide export ATP-binding/permease MacB YP_002740919.1 1564145 R 488221 CDS YP_002740920.1 225859410 7684343 complement(1565096..1567507) 1 NC_012468.1 alpha-fucosidase 1567507 7684343 SP70585_1695 Streptococcus pneumoniae 70585 alpha-fucosidase YP_002740920.1 1565096 R 488221 CDS YP_002740921.1 225859411 7684925 complement(1567560..1568252) 1 NC_012468.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase 1568252 gpmA 7684925 gpmA Streptococcus pneumoniae 70585 phosphoglyceromutase YP_002740921.1 1567560 R 488221 CDS YP_002740922.1 225859412 7684388 complement(1568303..1568491) 1 NC_012468.1 hypothetical protein 1568491 7684388 SP70585_1697 Streptococcus pneumoniae 70585 hypothetical protein YP_002740922.1 1568303 R 488221 CDS YP_002740923.1 225859413 7683871 complement(1568787..1569167) 1 NC_012468.1 integral membrane protein 1569167 7683871 SP70585_1698 Streptococcus pneumoniae 70585 integral membrane protein YP_002740923.1 1568787 R 488221 CDS YP_002740924.1 225859414 7684789 complement(1569577..1572369) 1 NC_012468.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase 1572369 ileS 7684789 ileS Streptococcus pneumoniae 70585 isoleucyl-tRNA synthetase YP_002740924.1 1569577 R 488221 CDS YP_002740925.1 225859415 7684535 complement(1572622..1572738) 1 NC_012468.1 hypothetical protein 1572738 7684535 SP70585_1700 Streptococcus pneumoniae 70585 hypothetical protein YP_002740925.1 1572622 R 488221 CDS YP_002740926.1 225859416 7684814 complement(1572717..1573505) 1 NC_012468.1 identified by match to protein family HMM PF05103; cell-division initiation protein 1573505 7684814 SP70585_1701 Streptococcus pneumoniae 70585 cell-division initiation protein YP_002740926.1 1572717 R 488221 CDS YP_002740927.1 225859417 7684464 complement(1573514..1574299) 1 NC_012468.1 identified by match to protein family HMM PF01479; YlmH protein 1574299 7684464 SP70585_1702 Streptococcus pneumoniae 70585 YlmH protein YP_002740927.1 1573514 R 488221 CDS YP_002740928.1 225859418 7684386 complement(1574296..1574559) 1 NC_012468.1 identified by match to protein family HMM PF02325; yggt family, putative 1574559 7684386 SP70585_1703 Streptococcus pneumoniae 70585 yggt family, putative YP_002740928.1 1574296 R 488221 CDS YP_002740929.1 225859419 7684950 complement(1574559..1575098) 1 NC_012468.1 identified by match to protein family HMM PF04472; YlmF protein 1575098 7684950 SP70585_1704 Streptococcus pneumoniae 70585 YlmF protein YP_002740929.1 1574559 R 488221 CDS YP_002740930.1 225859420 7684060 complement(1575108..1575779) 1 NC_012468.1 identified by match to protein family HMM TIGR00044; pyridoxal phosphate enzyme, YggS family 1575779 7684060 SP70585_1705 Streptococcus pneumoniae 70585 pyridoxal phosphate enzyme, YggS family YP_002740930.1 1575108 R 488221 CDS YP_002740931.1 225859421 7684671 complement(1575784..1577043) 1 NC_012468.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 1577043 ftsZ 7684671 ftsZ Streptococcus pneumoniae 70585 cell division protein FtsZ YP_002740931.1 1575784 R 488221 CDS YP_002740932.1 225859422 7684549 complement(1577060..1578433) 1 NC_012468.1 identified by match to protein family HMM PF02491; match to protein family HMM TIGR01174; cell division protein FtsA 1578433 ftsA 7684549 ftsA Streptococcus pneumoniae 70585 cell division protein FtsA YP_002740932.1 1577060 R 488221 CDS YP_002740933.1 225859423 7684206 complement(1578652..1579356) 1 NC_012468.1 identified by match to protein family HMM TIGR02206; hypothetical protein 1579356 7684206 SP70585_1708 Streptococcus pneumoniae 70585 hypothetical protein YP_002740933.1 1578652 R 488221 CDS YP_002740934.1 225859424 7684921 complement(1579447..1580058) 1 NC_012468.1 identified by match to protein family HMM PF00293; MutT/nudix family protein 1580058 7684921 SP70585_1709 Streptococcus pneumoniae 70585 MutT/nudix family protein YP_002740934.1 1579447 R 488221 CDS YP_002740935.1 225859425 7683821 complement(1580045..1581418) 1 NC_012468.1 identified by match to protein family HMM PF01225; match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01143; UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanyl ligase 1581418 7683821 SP70585_1710 Streptococcus pneumoniae 70585 UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanyl ligase YP_002740935.1 1580045 R 488221 CDS YP_002740936.1 225859426 7684038 complement(1581502..1582545) 1 NC_012468.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A 1582545 ddl 7684038 ddl Streptococcus pneumoniae 70585 D-alanyl-alanine synthetase A YP_002740936.1 1581502 R 488221 CDS YP_002740937.1 225859427 7683356 complement(1582721..1583317) 1 NC_012468.1 involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 1583317 recR 7683356 recR Streptococcus pneumoniae 70585 recombination protein RecR YP_002740937.1 1582721 R 488221 CDS YP_002740938.1 225859428 7683639 complement(1583328..1585370) 1 NC_012468.1 identified by match to protein family HMM PF00905; match to protein family HMM PF03717; penicillin-binding protein 2B 1585370 7683639 SP70585_1713 Streptococcus pneumoniae 70585 penicillin-binding protein 2B YP_002740938.1 1583328 R 488221 CDS YP_002740939.1 225859429 7684574 1585585..1586436 1 NC_012468.1 identified by match to protein family HMM PF01380; match to protein family HMM PF01418; transcriptional regulator, RpiR family 1586436 7684574 SP70585_1714 Streptococcus pneumoniae 70585 transcriptional regulator, RpiR family YP_002740939.1 1585585 D 488221 CDS YP_002740940.1 225859430 7684840 complement(1586452..1587336) 1 NC_012468.1 identified by match to protein family HMM PF00480; glucokinase 1587336 7684840 SP70585_1715 Streptococcus pneumoniae 70585 glucokinase YP_002740940.1 1586452 R 488221 CDS YP_002740941.1 225859431 7684987 complement(1587354..1588271) 1 NC_012468.1 identified by match to protein family HMM PF00701; N-acetylneuraminate lyase 1588271 7684987 SP70585_1716 Streptococcus pneumoniae 70585 N-acetylneuraminate lyase YP_002740941.1 1587354 R 488221 CDS YP_002740942.1 225859432 7684086 complement(1588440..1589084) 1 NC_012468.1 identified by match to protein family HMM PF04854; hypothetical protein 1589084 7684086 SP70585_1717 Streptococcus pneumoniae 70585 hypothetical protein YP_002740942.1 1588440 R 488221 CDS YP_002740943.1 225859433 7683589 complement(1589371..1589505) 1 NC_012468.1 hypothetical protein 1589505 7683589 SP70585_1718 Streptococcus pneumoniae 70585 hypothetical protein YP_002740943.1 1589371 R 488221 CDS YP_002740944.1 225859434 7684761 complement(1589812..1590264) 1 NC_012468.1 identified by match to protein family HMM PF04074; match to protein family HMM TIGR00022; hypothetical protein 1590264 7684761 SP70585_1719 Streptococcus pneumoniae 70585 hypothetical protein YP_002740944.1 1589812 R 488221 CDS YP_002740945.1 225859435 7683305 complement(1590537..1591376) 1 NC_012468.1 identified by match to protein family HMM PF00528; sugar ABC transporter permease 1591376 7683305 SP70585_1720 Streptococcus pneumoniae 70585 sugar ABC transporter permease YP_002740945.1 1590537 R 488221 CDS YP_002740946.1 225859436 7682920 complement(1591392..1592279) 1 NC_012468.1 identified by match to protein family HMM PF00528; sugar ABC transporter permease 1592279 7682920 SP70585_1721 Streptococcus pneumoniae 70585 sugar ABC transporter permease YP_002740946.1 1591392 R 488221 CDS YP_002740947.1 225859437 7684471 complement(1592510..1593838) 1 NC_012468.1 identified by match to protein family HMM PF01547; sugar ABC transporter substrate-binding protein 1593838 7684471 SP70585_1722 Streptococcus pneumoniae 70585 sugar ABC transporter substrate-binding protein YP_002740947.1 1592510 R 488221 CDS YP_002740948.1 225859438 7684878 complement(1593963..1595480) 1 NC_012468.1 identified by match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826; pts system maltose- and glucose-specific eiicb component 1595480 7684878 SP70585_1723 Streptococcus pneumoniae 70585 pts system maltose- and glucose-specific eiicb component YP_002740948.1 1593963 R 488221 CDS YP_002740949.1 225859439 7684184 complement(1595499..1596197) 1 NC_012468.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase 1596197 7684184 SP70585_1724 Streptococcus pneumoniae 70585 N-acetylmannosamine-6-phosphate 2-epimerase YP_002740949.1 1595499 R 488221 CDS YP_002740950.1 225859440 7683965 complement(1596371..1597474) 1 NC_012468.1 identified by match to protein family HMM PF01118; match to protein family HMM PF01408; match to protein family HMM PF02894; match to protein family HMM PF03447; putative oxidoreductase YjhC 1597474 7683965 SP70585_1725 Streptococcus pneumoniae 70585 putative oxidoreductase YjhC YP_002740950.1 1596371 R 488221 CDS YP_002740951.1 225859441 7684399 complement(1597486..1599579) 1 NC_012468.1 identified by match to protein family HMM PF02012; match to protein family HMM PF02973; sialidase B (Neuraminidase B) 1599579 7684399 SP70585_1726 Streptococcus pneumoniae 70585 sialidase B (Neuraminidase B) YP_002740951.1 1597486 R 488221 CDS YP_002740952.1 225859442 7682922 complement(1599598..1600431) 1 NC_012468.1 identified by match to protein family HMM PF00528; sugar ABC transporter permease 1600431 7682922 SP70585_1727 Streptococcus pneumoniae 70585 sugar ABC transporter permease YP_002740952.1 1599598 R 488221 CDS YP_002740953.1 225859443 7683497 complement(1600431..1601315) 1 NC_012468.1 identified by match to protein family HMM PF00528; sugar ABC transporter permease 1601315 7683497 SP70585_1728 Streptococcus pneumoniae 70585 sugar ABC transporter permease YP_002740953.1 1600431 R 488221 CDS YP_002740954.1 225859444 7684490 complement(1601394..1602731) 1 NC_012468.1 identified by match to protein family HMM PF01547; sugar ABC transporter substrate-binding protein 1602731 7684490 SP70585_1729 Streptococcus pneumoniae 70585 sugar ABC transporter substrate-binding protein YP_002740954.1 1601394 R 488221 CDS YP_002740955.1 225859445 7683572 complement(1602750..1603202) 1 NC_012468.1 identified by match to protein family HMM PF04074; match to protein family HMM TIGR00022; hypothetical protein 1603202 7683572 SP70585_1730 Streptococcus pneumoniae 70585 hypothetical protein YP_002740955.1 1602750 R 488221 CDS YP_002740956.1 225859446 7683195 complement(1604204..1607047) 1 NC_012468.1 identified by match to protein family HMM PF02012; match to protein family HMM PF02973; match to protein family HMM TIGR01167; neuraminidase 1607047 7683195 SP70585_1731 Streptococcus pneumoniae 70585 neuraminidase YP_002740956.1 1604204 R 488221 CDS YP_002740957.1 225859447 7685186 complement(1607404..1607631) 1 NC_012468.1 hypothetical protein 1607631 7685186 SP70585_1732 Streptococcus pneumoniae 70585 hypothetical protein YP_002740957.1 1607404 R 488221 CDS YP_002740958.1 225859448 7683869 1608029..1608442 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 1608442 7683869 SP70585_1733 Streptococcus pneumoniae 70585 hypothetical protein YP_002740958.1 1608029 D 488221 CDS YP_002740959.1 225859449 7683499 complement(1608796..1609776) 1 NC_012468.1 identified by match to protein family HMM PF05448; xylan esterase 1 1609776 7683499 SP70585_1734 Streptococcus pneumoniae 70585 xylan esterase 1 YP_002740959.1 1608796 R 488221 CDS YP_002740960.1 225859450 7684438 complement(1610102..1610350) 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 1610350 7684438 SP70585_1735 Streptococcus pneumoniae 70585 hypothetical protein YP_002740960.1 1610102 R 488221 CDS YP_002740961.1 225859451 7685048 complement(1610378..1612393) 1 NC_012468.1 catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG 1612393 recG 7685048 recG Streptococcus pneumoniae 70585 ATP-dependent DNA helicase RecG YP_002740961.1 1610378 R 488221 CDS YP_002740962.1 225859452 7684822 complement(1612412..1613515) 1 NC_012468.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase 1613515 alr 7684822 alr Streptococcus pneumoniae 70585 alanine racemase YP_002740962.1 1612412 R 488221 CDS YP_002740963.1 225859453 7683077 complement(1613505..1613867) 1 NC_012468.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase 1613867 acpS 7683077 acpS Streptococcus pneumoniae 70585 4'-phosphopantetheinyl transferase YP_002740963.1 1613505 R 488221 CDS YP_002740964.1 225859454 7682970 complement(1613912..1614943) 1 NC_012468.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 1614943 7682970 SP70585_1739 Streptococcus pneumoniae 70585 phospho-2-dehydro-3-deoxyheptonate aldolase YP_002740964.1 1613912 R 488221 CDS YP_002740965.1 225859455 7683964 complement(1614945..1615976) 1 NC_012468.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 1615976 7683964 SP70585_1740 Streptococcus pneumoniae 70585 phospho-2-dehydro-3-deoxyheptonate aldolase YP_002740965.1 1614945 R 488221 CDS YP_002740966.1 225859456 7684126 complement(1616057..1618570) 1 NC_012468.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 1618570 secA 7684126 secA Streptococcus pneumoniae 70585 preprotein translocase subunit SecA YP_002740966.1 1616057 R 488221 CDS YP_002740967.1 225859457 7683345 complement(1619033..1619665) 1 NC_012468.1 identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1619665 7683345 SP70585_1742 Streptococcus pneumoniae 70585 ABC transporter ATP-binding protein YP_002740967.1 1619033 R 488221 CDS YP_002740968.1 225859458 7684165 complement(1619669..1620310) 1 NC_012468.1 hypothetical protein 1620310 7684165 SP70585_1743 Streptococcus pneumoniae 70585 hypothetical protein YP_002740968.1 1619669 R 488221 CDS YP_002740969.1 225859459 7684577 complement(1620303..1621094) 1 NC_012468.1 hypothetical protein 1621094 7684577 SP70585_1744 Streptococcus pneumoniae 70585 hypothetical protein YP_002740969.1 1620303 R 488221 CDS YP_002740970.1 225859460 7684416 complement(1621279..1621614) 1 NC_012468.1 hypothetical protein 1621614 7684416 SP70585_1745 Streptococcus pneumoniae 70585 hypothetical protein YP_002740970.1 1621279 R 488221 CDS YP_002740971.1 225859461 7683156 complement(1621755..1622090) 1 NC_012468.1 hypothetical protein 1622090 7683156 SP70585_1746 Streptococcus pneumoniae 70585 hypothetical protein YP_002740971.1 1621755 R 488221 CDS YP_002740972.1 225859462 7685091 complement(1622181..1623491) 1 NC_012468.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 1623491 engA 7685091 engA Streptococcus pneumoniae 70585 GTP-binding protein EngA YP_002740972.1 1622181 R 488221 CDS YP_002740973.1 225859463 7683591 complement(1624215..1625111) 1 NC_012468.1 Primosomal protein that may act to load helicase DnaC during DNA replication; primosomal protein DnaI 1625111 7683591 SP70585_1750 Streptococcus pneumoniae 70585 primosomal protein DnaI YP_002740973.1 1624215 R 488221 CDS YP_002740974.1 225859464 7685191 complement(1625112..1626281) 1 NC_012468.1 identified by match to protein family HMM PF07261; replication initiation and membrane attachment protein 1626281 7685191 SP70585_1751 Streptococcus pneumoniae 70585 replication initiation and membrane attachment protein YP_002740974.1 1625112 R 488221 CDS YP_002740975.1 225859465 7684970 complement(1626282..1626755) 1 NC_012468.1 identified by match to protein family HMM PF03477; match to protein family HMM TIGR00244; transcriptional regulator NrdR 1626755 nrdR 7684970 nrdR Streptococcus pneumoniae 70585 transcriptional regulator NrdR YP_002740975.1 1626282 R 488221 CDS YP_002740976.1 225859466 7685174 1626895..1627260 1 NC_012468.1 identified by match to protein family HMM PF00392; GntR family transcriptional regulator 1627260 7685174 SP70585_1753 Streptococcus pneumoniae 70585 GntR family transcriptional regulator YP_002740976.1 1626895 D 488221 CDS YP_002740977.1 225859467 7683403 1627265..1627960 1 NC_012468.1 identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1627960 7683403 SP70585_1754 Streptococcus pneumoniae 70585 ABC transporter ATP-binding protein YP_002740977.1 1627265 D 488221 CDS YP_002740978.1 225859468 7684691 1627977..1628744 1 NC_012468.1 ABC transporter ATP-binding protein 1628744 7684691 SP70585_1755 Streptococcus pneumoniae 70585 ABC transporter ATP-binding protein YP_002740978.1 1627977 D 488221 CDS YP_002740979.1 225859469 7683753 complement(1629097..1630296) 1 NC_012468.1 Na+ ABC transporter permease 1630296 7683753 SP70585_1756 Streptococcus pneumoniae 70585 Na+ ABC transporter permease YP_002740979.1 1629097 R 488221 CDS YP_002740980.1 225859470 7684711 complement(1630293..1631186) 1 NC_012468.1 identified by match to protein family HMM PF00005; Na+ ABC transporter ATP-binding protein 1631186 7684711 SP70585_1757 Streptococcus pneumoniae 70585 Na+ ABC transporter ATP-binding protein YP_002740980.1 1630293 R 488221 CDS YP_002740981.1 225859471 7684036 1631309..1631500 1 NC_012468.1 chlorohydrolase 1631500 7684036 SP70585_1758 Streptococcus pneumoniae 70585 chlorohydrolase YP_002740981.1 1631309 D 488221 CDS YP_002740982.1 225859472 7683619 1632496..1633113 1 NC_012468.1 identified by match to protein family HMM PF09335; hypothetical protein 1633113 7683619 SP70585_1759 Streptococcus pneumoniae 70585 hypothetical protein YP_002740982.1 1632496 D 488221 CDS YP_002740983.1 225859473 7685004 complement(1633433..1634320) 1 NC_012468.1 identified by match to protein family HMM PF00480; fructokinase 1634320 7685004 SP70585_1760 Streptococcus pneumoniae 70585 fructokinase YP_002740983.1 1633433 R 488221 CDS YP_002740984.1 225859474 7683769 complement(1634469..1636352) 1 NC_012468.1 identified by match to protein family HMM PF00358; match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826; match to protein family HMM TIGR00830; match to protein family HMM TIGR01996; pts system, sucrose-specific iibc component 1636352 7683769 SP70585_1761 Streptococcus pneumoniae 70585 pts system, sucrose-specific iibc component YP_002740984.1 1634469 R 488221 CDS YP_002740985.1 225859475 7684667 complement(1636479..1636676) 1 NC_012468.1 hypothetical protein 1636676 7684667 SP70585_1762 Streptococcus pneumoniae 70585 hypothetical protein YP_002740985.1 1636479 R 488221 CDS YP_002740986.1 225859476 7684040 1636729..1638183 1 NC_012468.1 identified by match to protein family HMM PF00251; match to protein family HMM PF08244; match to protein family HMM TIGR01322; sucrose-6-phosphate hydrolase (Sucrase) (Invertase) 1638183 7684040 SP70585_1763 Streptococcus pneumoniae 70585 sucrose-6-phosphate hydrolase (Sucrase) (Invertase) YP_002740986.1 1636729 D 488221 CDS YP_002740987.1 225859477 7685019 1638164..1639129 1 NC_012468.1 identified by match to protein family HMM PF00356; match to protein family HMM PF00532; sucrose operon repressor (Scr operon regulatory protein) 1639129 7685019 SP70585_1764 Streptococcus pneumoniae 70585 sucrose operon repressor (Scr operon regulatory protein) YP_002740987.1 1638164 D 488221 CDS YP_002740988.1 225859478 7683715 complement(1639164..1640438) 1 NC_012468.1 identified by match to protein family HMM TIGR00532; hydroxymethylglutaryl-CoA reductase, degradative 1640438 7683715 SP70585_1765 Streptococcus pneumoniae 70585 hydroxymethylglutaryl-CoA reductase, degradative YP_002740988.1 1639164 R 488221 CDS YP_002740989.1 225859479 7682880 complement(1640438..1641634) 1 NC_012468.1 identified by match to protein family HMM PF01154; match to protein family HMM PF08540; match to protein family HMM TIGR01835; hydroxymethylglutaryl-CoA synthase 1641634 7682880 SP70585_1766 Streptococcus pneumoniae 70585 hydroxymethylglutaryl-CoA synthase YP_002740989.1 1640438 R 488221 CDS YP_002740990.1 225859480 7683256 complement(1641741..1642028) 1 NC_012468.1 hypothetical protein 1642028 7683256 SP70585_1767 Streptococcus pneumoniae 70585 hypothetical protein YP_002740990.1 1641741 R 488221 CDS YP_002740991.1 225859481 7683448 complement(1642057..1642446) 1 NC_012468.1 identified by match to protein family HMM PF01609; transposase (IS4 family) 1642446 7683448 SP70585_1768 Streptococcus pneumoniae 70585 transposase (IS4 family) YP_002740991.1 1642057 R 488221 CDS YP_002740992.1 225859482 7684915 complement(1642472..1642585) 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; tranposase 1642585 7684915 SP70585_1769 Streptococcus pneumoniae 70585 tranposase YP_002740992.1 1642472 R 488221 CDS YP_002740993.1 225859483 7684531 complement(1642744..1643193) 1 NC_012468.1 hypothetical protein 1643193 7684531 SP70585_1770 Streptococcus pneumoniae 70585 hypothetical protein YP_002740993.1 1642744 R 488221 CDS YP_002740994.1 225859484 7684432 complement(1643195..1643953) 1 NC_012468.1 identified by match to protein family HMM PF06738; hypothetical protein 1643953 7684432 SP70585_1771 Streptococcus pneumoniae 70585 hypothetical protein YP_002740994.1 1643195 R 488221 CDS YP_002740995.1 225859485 7684949 complement(1644068..1646047) 1 NC_012468.1 identified by match to protein family HMM PF00069; match to protein family HMM PF01163; match to protein family HMM PF03793; Stk1 1646047 7684949 SP70585_1772 Streptococcus pneumoniae 70585 Stk1 YP_002740995.1 1644068 R 488221 CDS YP_002740996.1 225859486 7683467 complement(1646044..1646784) 1 NC_012468.1 identified by match to protein family HMM PF00481; protein phosphatase PrpC 1646784 7683467 SP70585_1773 Streptococcus pneumoniae 70585 protein phosphatase PrpC YP_002740996.1 1646044 R 488221 CDS YP_002740997.1 225859487 7684904 complement(1646799..1648112) 1 NC_012468.1 identified by match to protein family HMM PF01029; match to protein family HMM PF01189; match to protein family HMM TIGR00563; ribosomal RNA small subunit methyltransferase B 1648112 sun 7684904 sun Streptococcus pneumoniae 70585 ribosomal RNA small subunit methyltransferase B YP_002740997.1 1646799 R 488221 CDS YP_002740998.1 225859488 7684788 complement(1648105..1649040) 1 NC_012468.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase 1649040 fmt 7684788 fmt Streptococcus pneumoniae 70585 methionyl-tRNA formyltransferase YP_002740998.1 1648105 R 488221 CDS YP_002740999.1 225859489 7683269 complement(1649053..1651449) 1 NC_012468.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA 1651449 7683269 SP70585_1776 Streptococcus pneumoniae 70585 primosome assembly protein PriA YP_002740999.1 1649053 R 488221 CDS YP_002741000.1 225859490 7683775 complement(1651515..1651826) 1 NC_012468.1 Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 1651826 7683775 SP70585_1777 Streptococcus pneumoniae 70585 DNA-directed RNA polymerase subunit omega YP_002741000.1 1651515 R 488221 CDS YP_002741001.1 225859491 7683440 complement(1651854..1652480) 1 NC_012468.1 Essential for recycling GMP and indirectly, cGMP; guanylate kinase 1652480 gmk 7683440 gmk Streptococcus pneumoniae 70585 guanylate kinase YP_002741001.1 1651854 R 488221 CDS YP_002741002.1 225859492 7683312 complement(1652610..1654223) 1 NC_012468.1 identified by match to protein family HMM PF00013; match to protein family HMM PF01966; match to protein family HMM TIGR00277; match to protein family HMM TIGR03319; hypothetical protein 1654223 7683312 SP70585_1779 Streptococcus pneumoniae 70585 hypothetical protein YP_002741002.1 1652610 R 488221 CDS YP_002741003.1 225859493 7683662 complement(1654492..1654722) 1 NC_012468.1 identified by match to protein family HMM PF02604; match to protein family HMM TIGR01552; prevent-host-death family protein 1654722 7683662 SP70585_1780 Streptococcus pneumoniae 70585 prevent-host-death family protein YP_002741003.1 1654492 R 488221 CDS YP_002741004.1 225859494 7684067 complement(1654960..1656057) 1 NC_012468.1 identified by match to protein family HMM PF05636; hypothetical protein 1656057 7684067 SP70585_1781 Streptococcus pneumoniae 70585 hypothetical protein YP_002741004.1 1654960 R 488221 CDS YP_002741005.1 225859495 7685130 complement(1656067..1656813) 1 NC_012468.1 identified by match to protein family HMM PF08241; match to protein family HMM PF08242; SAM-dependent methyltransferase 1656813 7685130 SP70585_1782 Streptococcus pneumoniae 70585 SAM-dependent methyltransferase YP_002741005.1 1656067 R 488221 CDS YP_002741006.1 225859496 7685193 complement(1656916..1657269) 1 NC_012468.1 identified by match to protein family HMM PF02410; match to protein family HMM TIGR00090; putative iojap homolog 1657269 7685193 SP70585_1783 Streptococcus pneumoniae 70585 putative iojap homolog YP_002741006.1 1656916 R 488221 CDS YP_002741007.1 225859497 7684929 complement(1657282..1657782) 1 NC_012468.1 identified by match to protein family HMM PF00857; isochorismatase family protein 1657782 7684929 SP70585_1784 Streptococcus pneumoniae 70585 isochorismatase family protein YP_002741007.1 1657282 R 488221 CDS YP_002741008.1 225859498 7684817 complement(1657783..1658376) 1 NC_012468.1 identified by match to protein family HMM PF01966; match to protein family HMM TIGR00488; hypothetical protein 1658376 7684817 SP70585_1785 Streptococcus pneumoniae 70585 hypothetical protein YP_002741008.1 1657783 R 488221 CDS YP_002741009.1 225859499 7684538 complement(1658376..1659005) 1 NC_012468.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase 1659005 nadD 7684538 nadD Streptococcus pneumoniae 70585 nicotinic acid mononucleotide adenylyltransferase YP_002741009.1 1658376 R 488221 CDS YP_002741010.1 225859500 7684394 complement(1659057..1659368) 1 NC_012468.1 identified by match to protein family HMM PF01985; match to protein family HMM TIGR00253; hypothetical protein 1659368 7684394 SP70585_1787 Streptococcus pneumoniae 70585 hypothetical protein YP_002741010.1 1659057 R 488221 CDS YP_002741011.1 225859501 7684062 complement(1659582..1660688) 1 NC_012468.1 in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis; GTP-binding protein YqeH 1660688 7684062 SP70585_1788 Streptococcus pneumoniae 70585 GTP-binding protein YqeH YP_002741011.1 1659582 R 488221 CDS YP_002741012.1 225859502 7685183 complement(1660691..1661218) 1 NC_012468.1 identified by match to protein family HMM TIGR01662; match to protein family HMM TIGR01668; had superfamily (subfamily iiia) phosphatase 1661218 yqeG 7685183 yqeG Streptococcus pneumoniae 70585 had superfamily (subfamily iiia) phosphatase YP_002741012.1 1660691 R 488221 CDS YP_002741013.1 225859503 7684225 complement(1661233..1662141) 1 NC_012468.1 identified by match to protein family HMM PF01544; CorA - magnesium and cobalt transporter 1662141 7684225 SP70585_1790 Streptococcus pneumoniae 70585 CorA - magnesium and cobalt transporter YP_002741013.1 1661233 R 488221 CDS YP_002741014.1 225859504 7685043 complement(1662198..1662758) 1 NC_012468.1 identified by match to protein family HMM PF00924; small conductance mechanosensitive ion channel 1662758 7685043 SP70585_1791 Streptococcus pneumoniae 70585 small conductance mechanosensitive ion channel YP_002741014.1 1662198 R 488221 CDS YP_002741015.1 225859505 7683842 1663147..1664115 1 NC_012468.1 involved in the import of serine and threonine coupled with the import of sodium; serine/threonine transporter SstT 1664115 7683842 SP70585_1792 Streptococcus pneumoniae 70585 serine/threonine transporter SstT YP_002741015.1 1663147 D 488221 CDS YP_002741016.1 225859506 7685039 1664183..1665136 1 NC_012468.1 identified by match to protein family HMM PF06081; integral membrane protein 1665136 7685039 SP70585_1793 Streptococcus pneumoniae 70585 integral membrane protein YP_002741016.1 1664183 D 488221 CDS YP_002741017.1 225859507 7684436 complement(1665159..1665536) 1 NC_012468.1 hypothetical protein 1665536 7684436 SP70585_1794 Streptococcus pneumoniae 70585 hypothetical protein YP_002741017.1 1665159 R 488221 CDS YP_002741018.1 225859508 7683111 complement(1665597..1665821) 1 NC_012468.1 hypothetical protein 1665821 7683111 SP70585_1795 Streptococcus pneumoniae 70585 hypothetical protein YP_002741018.1 1665597 R 488221 CDS YP_002741019.1 225859509 7684854 complement(1665826..1666005) 1 NC_012468.1 hypothetical protein 1666005 7684854 SP70585_1796 Streptococcus pneumoniae 70585 hypothetical protein YP_002741019.1 1665826 R 488221 CDS YP_002741020.1 225859510 7684182 complement(1666007..1667344) 1 NC_012468.1 identified by match to protein family HMM TIGR02919; hypothetical protein 1667344 7684182 SP70585_1797 Streptococcus pneumoniae 70585 hypothetical protein YP_002741020.1 1666007 R 488221 CDS YP_002741021.1 225859511 7684869 complement(1667337..1668848) 1 NC_012468.1 identified by match to protein family HMM PF00534; match to protein family HMM PF09318; match to protein family HMM TIGR02918; hypothetical protein 1668848 7684869 SP70585_1798 Streptococcus pneumoniae 70585 hypothetical protein YP_002741021.1 1667337 R 488221 CDS YP_002741022.1 225859512 7683121 complement(1671226..1671666) 1 NC_012468.1 accessory secretory protein Asp3 1671666 7683121 SP70585_1801 Streptococcus pneumoniae 70585 accessory secretory protein Asp3 YP_002741022.1 1671226 R 488221 CDS YP_002741023.1 225859513 7685163 complement(1671663..1673198) 1 NC_012468.1 accessory secretory protein Asp2 1673198 7685163 SP70585_1802 Streptococcus pneumoniae 70585 accessory secretory protein Asp2 YP_002741023.1 1671663 R 488221 CDS YP_002741024.1 225859514 7683268 complement(1673182..1674762) 1 NC_012468.1 accessory secretory protein Asp1 1674762 7683268 SP70585_1803 Streptococcus pneumoniae 70585 accessory secretory protein Asp1 YP_002741024.1 1673182 R 488221 CDS YP_002741025.1 225859515 7682907 complement(1674772..1675989) 1 NC_012468.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 1675989 secY 7682907 secY Streptococcus pneumoniae 70585 preprotein translocase subunit SecY YP_002741025.1 1674772 R 488221 CDS YP_002741026.1 225859516 7683282 complement(1676046..1676951) 1 NC_012468.1 identified by match to protein family HMM PF00535; glycosyl transferase, family 2 1676951 7683282 SP70585_1805 Streptococcus pneumoniae 70585 glycosyl transferase, family 2 YP_002741026.1 1676046 R 488221 CDS YP_002741027.1 225859517 7684447 complement(1676951..1678147) 1 NC_012468.1 identified by match to protein family HMM PF01501; glycosyl transferase, family 8 1678147 7684447 SP70585_1806 Streptococcus pneumoniae 70585 glycosyl transferase, family 8 YP_002741027.1 1676951 R 488221 CDS YP_002741028.1 225859518 7683618 complement(1678156..1679205) 1 NC_012468.1 identified by match to protein family HMM PF01501; glycosyl transferase, family 8 1679205 7683618 SP70585_1807 Streptococcus pneumoniae 70585 glycosyl transferase, family 8 YP_002741028.1 1678156 R 488221 CDS YP_002741029.1 225859519 7684039 complement(1679407..1681851) 1 NC_012468.1 identified by match to protein family HMM PF01501; match to protein family HMM PF08759; glycosyl transferase, family 8 1681851 7684039 SP70585_1808 Streptococcus pneumoniae 70585 glycosyl transferase, family 8 YP_002741029.1 1679407 R 488221 CDS YP_002741030.1 225859520 7684931 complement(1681861..1682871) 1 NC_012468.1 hypothetical protein 1682871 7684931 SP70585_1809 Streptococcus pneumoniae 70585 hypothetical protein YP_002741030.1 1681861 R 488221 CDS YP_002741031.1 225859521 7683844 complement(1683817..1684695) 1 NC_012468.1 identified by match to protein family HMM PF00132; exopolysaccharide biosynthesis protein, acetyltransferase 1684695 7683844 SP70585_1811 Streptococcus pneumoniae 70585 exopolysaccharide biosynthesis protein, acetyltransferase YP_002741031.1 1683817 R 488221 CDS YP_002741032.1 225859522 7683554 complement(1684692..1686386) 1 NC_012468.1 identified by match to protein family HMM PF01501; glycosyl transferase, family 2/glycosyl transferase family 8 1686386 7683554 SP70585_1812 Streptococcus pneumoniae 70585 glycosyl transferase, family 2/glycosyl transferase family 8 YP_002741032.1 1684692 R 488221 CDS YP_002741033.1 225859523 7684941 complement(1686428..1686805) 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01609; transposase (IS4 family) 1686805 7684941 SP70585_1813 Streptococcus pneumoniae 70585 transposase (IS4 family) YP_002741033.1 1686428 R 488221 CDS YP_002741034.1 225859524 7684268 complement(1686817..1687278) 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase 1687278 7684268 SP70585_1814 Streptococcus pneumoniae 70585 transposase YP_002741034.1 1686817 R 488221 CDS YP_002741035.1 225859525 7683630 complement(1687281..1687640) 1 NC_012468.1 putative glycosyltransferase YibD 1687640 7683630 SP70585_1815 Streptococcus pneumoniae 70585 putative glycosyltransferase YibD YP_002741035.1 1687281 R 488221 CDS YP_002741036.1 225859526 7683066 complement(1687701..1694348) 1 NC_012468.1 identified by match to protein family HMM PF00746; match to protein family HMM TIGR01167; cell wall surface anchor family protein 1694348 7683066 SP70585_1816 Streptococcus pneumoniae 70585 cell wall surface anchor family protein YP_002741036.1 1687701 R 488221 CDS YP_002741037.1 225859527 7684696 complement(1694687..1695007) 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; Spn1, transposase Orf2 1695007 7684696 SP70585_1817 Streptococcus pneumoniae 70585 Spn1, transposase Orf2 YP_002741037.1 1694687 R 488221 CDS YP_002741038.1 225859528 7682916 complement(1694983..1695156) 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; hypothetical protein 1695156 7682916 SP70585_1818 Streptococcus pneumoniae 70585 hypothetical protein YP_002741038.1 1694983 R 488221 CDS YP_002741039.1 225859529 7683257 1695533..1695913 1 NC_012468.1 identified by match to protein family HMM PF01047; transcriptional regulator, putative 1695913 7683257 SP70585_1819 Streptococcus pneumoniae 70585 transcriptional regulator, putative YP_002741039.1 1695533 D 488221 CDS YP_002741040.1 225859530 7683696 1696012..1696233 1 NC_012468.1 hypothetical protein 1696233 7683696 SP70585_1820 Streptococcus pneumoniae 70585 hypothetical protein YP_002741040.1 1696012 D 488221 CDS YP_002741041.1 225859531 7684502 1696250..1696564 1 NC_012468.1 identified by match to protein family HMM PF00085; match to protein family HMM TIGR01068; thioredoxin 1696564 trx 7684502 trx Streptococcus pneumoniae 70585 thioredoxin YP_002741041.1 1696250 D 488221 CDS YP_002741042.1 225859532 7684011 1696872..1697405 1 NC_012468.1 NADPH-dependent; catalyzes the reduction of 7-cyano-7-deazaguanine to 7-aminomethyl-7-deazaguanine in queuosine biosynthesis; 7-cyano-7-deazaguanine reductase 1697405 7684011 SP70585_1822 Streptococcus pneumoniae 70585 7-cyano-7-deazaguanine reductase YP_002741042.1 1696872 D 488221 CDS YP_002741043.1 225859533 7684198 complement(1697659..1698327) 1 NC_012468.1 identified by match to protein family HMM PF00230; aquaporin Z - water channel protein 1698327 7684198 SP70585_1823 Streptococcus pneumoniae 70585 aquaporin Z - water channel protein YP_002741043.1 1697659 R 488221 CDS YP_002741044.1 225859534 7684122 complement(1698438..1699229) 1 NC_012468.1 hypothetical protein 1699229 7684122 SP70585_1824 Streptococcus pneumoniae 70585 hypothetical protein YP_002741044.1 1698438 R 488221 CDS YP_002741045.1 225859535 7682934 complement(1699297..1699452) 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 1699452 7682934 SP70585_1825 Streptococcus pneumoniae 70585 hypothetical protein YP_002741045.1 1699297 R 488221 CDS YP_002741046.1 225859536 7683214 complement(1699476..1701272) 1 NC_012468.1 identified by match to protein family HMM PF01432; match to protein family HMM PF08439; match to protein family HMM TIGR00181; oligoendopeptidase F 1701272 pepF2 7683214 pepF2 Streptococcus pneumoniae 70585 oligoendopeptidase F YP_002741046.1 1699476 R 488221 CDS YP_002741047.1 225859537 7684743 complement(1701283..1702026) 1 NC_012468.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 1702026 7684743 SP70585_1827 Streptococcus pneumoniae 70585 16S ribosomal RNA methyltransferase RsmE YP_002741047.1 1701283 R 488221 CDS YP_002741048.1 225859538 7683484 complement(1702028..1702978) 1 NC_012468.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; ribosomal protein L11 methyltransferase 1702978 prmA 7683484 prmA Streptococcus pneumoniae 70585 ribosomal protein L11 methyltransferase YP_002741048.1 1702028 R 488221 CDS YP_002741049.1 225859539 7684380 complement(1703116..1703544) 1 NC_012468.1 identified by match to protein family HMM PF00293; 7,8-dihydro-8-oxoguanine-triphosphatase 1703544 7684380 SP70585_1829 Streptococcus pneumoniae 70585 7,8-dihydro-8-oxoguanine-triphosphatase YP_002741049.1 1703116 R 488221 CDS YP_002741050.1 225859540 7683444 complement(1703525..1704613) 1 NC_012468.1 identified by match to protein family HMM PF02163; peptidase, M50 family protein 1704613 7683444 SP70585_1830 Streptococcus pneumoniae 70585 peptidase, M50 family protein YP_002741050.1 1703525 R 488221 CDS YP_002741051.1 225859541 7683813 complement(1704632..1705102) 1 NC_012468.1 hypothetical protein 1705102 7683813 SP70585_1831 Streptococcus pneumoniae 70585 hypothetical protein YP_002741051.1 1704632 R 488221 CDS YP_002741052.1 225859542 7683522 complement(1705393..1705845) 1 NC_012468.1 identified by match to protein family HMM PF03681; hypothetical protein 1705845 7683522 SP70585_1832 Streptococcus pneumoniae 70585 hypothetical protein YP_002741052.1 1705393 R 488221 CDS YP_002741053.1 225859543 7684097 complement(1705882..1706061) 1 NC_012468.1 identified by match to protein family HMM PF07927; hypothetical protein 1706061 7684097 SP70585_1833 Streptococcus pneumoniae 70585 hypothetical protein YP_002741053.1 1705882 R 488221 CDS YP_002741054.1 225859544 7683183 complement(1706198..1706377) 1 NC_012468.1 hypothetical protein 1706377 7683183 SP70585_1834 Streptococcus pneumoniae 70585 hypothetical protein YP_002741054.1 1706198 R 488221 CDS YP_002741055.1 225859545 7685135 complement(1706581..1706781) 1 NC_012468.1 hypothetical protein 1706781 7685135 SP70585_1835 Streptococcus pneumoniae 70585 hypothetical protein YP_002741055.1 1706581 R 488221 CDS YP_002741056.1 225859546 7684846 1707051..1708322 1 NC_012468.1 identified by match to protein family HMM PF00004; recombination factor protein RarA 1708322 7684846 SP70585_1836 Streptococcus pneumoniae 70585 recombination factor protein RarA YP_002741056.1 1707051 D 488221 CDS YP_002741057.1 225859547 7683914 complement(1708742..1709707) 1 NC_012468.1 identified by match to protein family HMM PF00589; integrase 1709707 7683914 SP70585_1838 Streptococcus pneumoniae 70585 integrase YP_002741057.1 1708742 R 488221 CDS YP_002741058.1 225859548 7683513 complement(1709870..1710052) 1 NC_012468.1 hypothetical protein 1710052 7683513 SP70585_1839 Streptococcus pneumoniae 70585 hypothetical protein YP_002741058.1 1709870 R 488221 CDS YP_002741059.1 225859549 7684168 complement(1710068..1711111) 1 NC_012468.1 hypothetical protein 1711111 7684168 SP70585_1840 Streptococcus pneumoniae 70585 hypothetical protein YP_002741059.1 1710068 R 488221 CDS YP_002741060.1 225859550 7684685 complement(1711245..1711412) 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 1711412 7684685 SP70585_1841 Streptococcus pneumoniae 70585 hypothetical protein YP_002741060.1 1711245 R 488221 CDS YP_002741061.1 225859551 7683128 complement(1711684..1712991) 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 1712991 7683128 SP70585_1842 Streptococcus pneumoniae 70585 hypothetical protein YP_002741061.1 1711684 R 488221 CDS YP_002741062.1 225859552 7684546 complement(1712999..1713121) 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 1713121 7684546 SP70585_1843 Streptococcus pneumoniae 70585 hypothetical protein YP_002741062.1 1712999 R 488221 CDS YP_002741063.1 225859553 7684797 complement(1713207..1713428) 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 1713428 7684797 SP70585_1844 Streptococcus pneumoniae 70585 hypothetical protein YP_002741063.1 1713207 R 488221 CDS YP_002741064.1 225859554 7685087 complement(1713482..1713781) 1 NC_012468.1 hypothetical protein 1713781 7685087 SP70585_1845 Streptococcus pneumoniae 70585 hypothetical protein YP_002741064.1 1713482 R 488221 CDS YP_002741065.1 225859555 7684478 complement(1715107..1716426) 1 NC_012468.1 identified by match to protein family HMM PF00251; match to protein family HMM TIGR01322; sucrose-6-phosphate hydrolase 1716426 7684478 SP70585_1846 Streptococcus pneumoniae 70585 sucrose-6-phosphate hydrolase YP_002741065.1 1715107 R 488221 CDS YP_002741066.1 225859556 7683152 complement(1716436..1717281) 1 NC_012468.1 identified by match to protein family HMM PF00528; sugar ABC transporter permease 1717281 7683152 SP70585_1847 Streptococcus pneumoniae 70585 sugar ABC transporter permease YP_002741066.1 1716436 R 488221 CDS YP_002741067.1 225859557 7683887 complement(1717283..1718185) 1 NC_012468.1 identified by match to protein family HMM PF00528; ABC transporter permease 1718185 7683887 SP70585_1848 Streptococcus pneumoniae 70585 ABC transporter permease YP_002741067.1 1717283 R 488221 CDS YP_002741068.1 225859558 7683975 complement(1718281..1719591) 1 NC_012468.1 identified by match to protein family HMM PF01547; sugar ABC transporter substrate-binding protein 1719591 7683975 SP70585_1849 Streptococcus pneumoniae 70585 sugar ABC transporter substrate-binding protein YP_002741068.1 1718281 R 488221 CDS YP_002741069.1 225859559 7684614 complement(1719718..1720713) 1 NC_012468.1 identified by match to protein family HMM PF00356; match to protein family HMM PF00532; sugar-binding transcriptional regulator, LacI family protein 1720713 7684614 SP70585_1850 Streptococcus pneumoniae 70585 sugar-binding transcriptional regulator, LacI family protein YP_002741069.1 1719718 R 488221 CDS YP_002741070.1 225859560 7684265 complement(1721075..1722556) 1 NC_012468.1 identified by match to protein family HMM PF05043; match to protein family HMM PF08270; match to protein family HMM PF08279; match to protein family HMM PF08280; M protein trans-acting positive transcriptional regulator 1722556 7684265 SP70585_1851 Streptococcus pneumoniae 70585 M protein trans-acting positive transcriptional regulator YP_002741070.1 1721075 R 488221 CDS YP_002741071.1 225859561 7684044 1722967..1723164 1 NC_012468.1 identified by match to protein family HMM PF04226; hypothetical protein 1723164 7684044 SP70585_1852 Streptococcus pneumoniae 70585 hypothetical protein YP_002741071.1 1722967 D 488221 CDS YP_002741072.1 225859562 7684606 1723248..1723814 1 NC_012468.1 hypothetical protein 1723814 7684606 SP70585_1853 Streptococcus pneumoniae 70585 hypothetical protein YP_002741072.1 1723248 D 488221 CDS YP_002741073.1 225859563 7683699 1723826..1723996 1 NC_012468.1 lipoprotein, putative 1723996 7683699 SP70585_1854 Streptococcus pneumoniae 70585 lipoprotein, putative YP_002741073.1 1723826 D 488221 CDS YP_002741074.1 225859564 7683202 1724035..1724643 1 NC_012468.1 identified by match to protein family HMM PF03780; Gls24 protein 1724643 7683202 SP70585_1855 Streptococcus pneumoniae 70585 Gls24 protein YP_002741074.1 1724035 D 488221 CDS YP_002741075.1 225859565 7685198 1724674..1724877 1 NC_012468.1 identified by match to protein family HMM PF05532; hypothetical protein 1724877 7685198 SP70585_1856 Streptococcus pneumoniae 70585 hypothetical protein YP_002741075.1 1724674 D 488221 CDS YP_002741076.1 225859566 7684170 complement(1724987..1725226) 1 NC_012468.1 hypothetical protein 1725226 7684170 SP70585_1857 Streptococcus pneumoniae 70585 hypothetical protein YP_002741076.1 1724987 R 488221 CDS YP_002741077.1 225859567 7684173 complement(1725691..1725810) 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 1725810 7684173 SP70585_1858 Streptococcus pneumoniae 70585 hypothetical protein YP_002741077.1 1725691 R 488221 CDS YP_002741078.1 225859568 7684768 complement(1726028..1726798) 1 NC_012468.1 identified by match to protein family HMM PF01925; hypothetical protein 1726798 7684768 SP70585_1859 Streptococcus pneumoniae 70585 hypothetical protein YP_002741078.1 1726028 R 488221 CDS YP_002741079.1 225859569 7683304 complement(1726813..1727661) 1 NC_012468.1 identified by match to protein family HMM PF03781; sulfatase-modifying factor 1 (C-alpha-formyglycine-generating enzyme 1) 1727661 7683304 SP70585_1860 Streptococcus pneumoniae 70585 sulfatase-modifying factor 1 (C-alpha-formyglycine-generating enzyme 1) YP_002741079.1 1726813 R 488221 CDS YP_002741080.1 225859570 7684112 complement(1727658..1729133) 1 NC_012468.1 can hydrolyze p-nitrophenyl sulfate; contains a specific cysteine that is converted into C{alpha]-formylglycine upon activation with the anaerobic sulfatase-maturase; arylsulfatase 1729133 7684112 SP70585_1861 Streptococcus pneumoniae 70585 arylsulfatase YP_002741080.1 1727658 R 488221 CDS YP_002741081.1 225859571 7685022 complement(1729456..1730811) 1 NC_012468.1 identified by match to protein family HMM PF02378; match to protein family HMM TIGR00410; phosphotransferase system 1730811 7685022 SP70585_1862 Streptococcus pneumoniae 70585 phosphotransferase system YP_002741081.1 1729456 R 488221 CDS YP_002741082.1 225859572 7684866 complement(1730821..1731138) 1 NC_012468.1 identified by match to protein family HMM PF02255; lichenan-specific phosphotransferase enzyme iia component (pts system lichenan-specific eiia component) (eiia-lic) (eiii-lic) 1731138 7684866 SP70585_1863 Streptococcus pneumoniae 70585 lichenan-specific phosphotransferase enzyme iia component (pts system lichenan-specific eiia component) (eiia-lic) (eiii-lic) YP_002741082.1 1730821 R 488221 CDS YP_002741083.1 225859573 7684144 complement(1731155..1731472) 1 NC_012468.1 identified by match to protein family HMM PF02302; lichenan-specific phosphotransferase enzyme iib component (pts system lichenan-specific eiib component) (eiib-lic) 1731472 7684144 SP70585_1864 Streptococcus pneumoniae 70585 lichenan-specific phosphotransferase enzyme iib component (pts system lichenan-specific eiib component) (eiib-lic) YP_002741083.1 1731155 R 488221 CDS YP_002741084.1 225859574 7684000 complement(1731487..1732383) 1 NC_012468.1 hypothetical protein 1732383 7684000 SP70585_1865 Streptococcus pneumoniae 70585 hypothetical protein YP_002741084.1 1731487 R 488221 CDS YP_002741085.1 225859575 7683212 complement(1732386..1733648) 1 NC_012468.1 identified by match to protein family HMM PF02378; match to protein family HMM TIGR00410; lichenan permease iic component (pts system lichenan-specific eiiccomponent) (eiic-lic) 1733648 7683212 SP70585_1866 Streptococcus pneumoniae 70585 lichenan permease iic component (pts system lichenan-specific eiiccomponent) (eiic-lic) YP_002741085.1 1732386 R 488221 CDS YP_002741086.1 225859576 7684776 1733928..1735106 1 NC_012468.1 identified by match to protein family HMM PF00480; ROK family protein, putative 1735106 7684776 SP70585_1867 Streptococcus pneumoniae 70585 ROK family protein, putative YP_002741086.1 1733928 D 488221 CDS YP_002741087.1 225859577 7683717 complement(1735334..1735780) 1 NC_012468.1 identified by match to protein family HMM PF00583; acetyltransferase, gnat family 1735780 7683717 SP70585_1868 Streptococcus pneumoniae 70585 acetyltransferase, gnat family YP_002741087.1 1735334 R 488221 CDS YP_002741088.1 225859578 7684153 1735850..1736509 1 NC_012468.1 identified by match to protein family HMM PF01478; match to protein family HMM PF06750; type 4 prepilin peptidase 1736509 7684153 SP70585_1869 Streptococcus pneumoniae 70585 type 4 prepilin peptidase YP_002741088.1 1735850 D 488221 CDS YP_002741089.1 225859579 7683015 complement(1736561..1737712) 1 NC_012468.1 identified by match to protein family HMM PF01381; match to protein family HMM PF06114; transcriptional regulator 1737712 7683015 SP70585_1870 Streptococcus pneumoniae 70585 transcriptional regulator YP_002741089.1 1736561 R 488221 CDS YP_002741090.1 225859580 7684185 complement(1737727..1738458) 1 NC_012468.1 hypothetical protein 1738458 7684185 SP70585_1871 Streptococcus pneumoniae 70585 hypothetical protein YP_002741090.1 1737727 R 488221 CDS YP_002741091.1 225859581 7685081 complement(1738760..1739536) 1 NC_012468.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 1739536 trpA 7685081 trpA Streptococcus pneumoniae 70585 tryptophan synthase subunit alpha YP_002741091.1 1738760 R 488221 CDS YP_002741092.1 225859582 7684504 complement(1739529..1740752) 1 NC_012468.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 1740752 trpB 7684504 trpB Streptococcus pneumoniae 70585 tryptophan synthase subunit beta YP_002741092.1 1739529 R 488221 CDS YP_002741093.1 225859583 7683226 complement(1740730..1741329) 1 NC_012468.1 catalyzes the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)-anthranilate in tryptophan biosynthesis; N-(5'-phosphoribosyl)anthranilate isomerase 1741329 trpF 7683226 trpF Streptococcus pneumoniae 70585 N-(5'-phosphoribosyl)anthranilate isomerase YP_002741093.1 1740730 R 488221 CDS YP_002741094.1 225859584 7684373 complement(1741316..1742083) 1 NC_012468.1 involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water; indole-3-glycerol-phosphate synthase 1742083 trpC 7684373 trpC Streptococcus pneumoniae 70585 indole-3-glycerol-phosphate synthase YP_002741094.1 1741316 R 488221 CDS YP_002741095.1 225859585 7685107 complement(1742080..1743084) 1 NC_012468.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate; anthranilate phosphoribosyltransferase 1743084 trpD 7685107 trpD Streptococcus pneumoniae 70585 anthranilate phosphoribosyltransferase YP_002741095.1 1742080 R 488221 CDS YP_002741096.1 225859586 7684785 complement(1743095..1743661) 1 NC_012468.1 TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity; anthranilate synthase component II 1743661 7684785 SP70585_1877 Streptococcus pneumoniae 70585 anthranilate synthase component II YP_002741096.1 1743095 R 488221 CDS YP_002741097.1 225859587 7684666 complement(1743658..1745019) 1 NC_012468.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I 1745019 trpE 7684666 trpE Streptococcus pneumoniae 70585 anthranilate synthase component I YP_002741097.1 1743658 R 488221 CDS YP_002741098.1 225859588 7683070 complement(1745154..1745309) 1 NC_012468.1 hypothetical protein 1745309 7683070 SP70585_1879 Streptococcus pneumoniae 70585 hypothetical protein YP_002741098.1 1745154 R 488221 CDS YP_002741099.1 225859589 7684629 complement(1745313..1745432) 1 NC_012468.1 hypothetical protein 1745432 7684629 SP70585_1880 Streptococcus pneumoniae 70585 hypothetical protein YP_002741099.1 1745313 R 488221 CDS YP_002741100.1 225859590 7682928 complement(1745392..1745598) 1 NC_012468.1 chlorohydrolase 1745598 7682928 SP70585_1881 Streptococcus pneumoniae 70585 chlorohydrolase YP_002741100.1 1745392 R 488221 CDS YP_002741101.1 225859591 7683270 complement(1746206..1747207) 1 NC_012468.1 identified by match to protein family HMM PF00356; match to protein family HMM PF00532; catabolite control protein 1747207 7683270 SP70585_1882 Streptococcus pneumoniae 70585 catabolite control protein YP_002741101.1 1746206 R 488221 CDS YP_002741102.1 225859592 7683456 complement(1747779..1748489) 1 NC_012468.1 identified by match to protein family HMM PF02308; putative Mg2+ transporter-C (MgtC) family protein 1748489 7683456 SP70585_1883 Streptococcus pneumoniae 70585 putative Mg2+ transporter-C (MgtC) family protein YP_002741102.1 1747779 R 488221 CDS YP_002741103.1 225859593 7683629 complement(1748492..1750183) 1 NC_012468.1 identified by match to protein family HMM PF00528; binding-protein-dependent transport systems inner membrane component 1750183 7683629 SP70585_1884 Streptococcus pneumoniae 70585 binding-protein-dependent transport systems inner membrane component YP_002741103.1 1748492 R 488221 CDS YP_002741104.1 225859594 7684620 complement(1750195..1751205) 1 NC_012468.1 identified by match to protein family HMM PF00005; match to protein family HMM PF03459; match to protein family HMM PF08402; spermidine/putrescine import ATP-binding protein PotA 1751205 7684620 SP70585_1885 Streptococcus pneumoniae 70585 spermidine/putrescine import ATP-binding protein PotA YP_002741104.1 1750195 R 488221 CDS YP_002741105.1 225859595 7684944 complement(1751308..1752375) 1 NC_012468.1 ABC transporter substrate-binding protein 1752375 7684944 SP70585_1886 Streptococcus pneumoniae 70585 ABC transporter substrate-binding protein YP_002741105.1 1751308 R 488221 CDS YP_002741106.1 225859596 7684384 complement(1752400..1753059) 1 NC_012468.1 identified by match to protein family HMM PF08975; hypothetical protein 1753059 7684384 SP70585_1887 Streptococcus pneumoniae 70585 hypothetical protein YP_002741106.1 1752400 R 488221 CDS YP_002741107.1 225859597 7684694 complement(1753170..1753283) 1 NC_012468.1 hypothetical protein 1753283 7684694 SP70585_1888 Streptococcus pneumoniae 70585 hypothetical protein YP_002741107.1 1753170 R 488221 CDS YP_002741108.1 225859598 7685053 complement(1753784..1754080) 1 NC_012468.1 hypothetical protein 1754080 7685053 SP70585_1889 Streptococcus pneumoniae 70585 hypothetical protein YP_002741108.1 1753784 R 488221 CDS YP_002741109.1 225859599 7684461 complement(1754064..1756190) 1 NC_012468.1 identified by match to protein family HMM PF04650; match to protein family HMM TIGR01168; cell wall surface anchor family protein 1756190 7684461 SP70585_1890 Streptococcus pneumoniae 70585 cell wall surface anchor family protein YP_002741109.1 1754064 R 488221 CDS YP_002741110.1 225859600 7684103 complement(1757354..1758580) 1 NC_012468.1 identified by match to protein family HMM PF01041; Cps7G 1758580 7684103 SP70585_1891 Streptococcus pneumoniae 70585 Cps7G YP_002741110.1 1757354 R 488221 CDS YP_002741111.1 225859601 7682968 complement(1758623..1759315) 1 NC_012468.1 identified by match to protein family HMM PF02397; sugar transferase family protein 1759315 7682968 SP70585_1892 Streptococcus pneumoniae 70585 sugar transferase family protein YP_002741111.1 1758623 R 488221 CDS YP_002741112.1 225859602 7684792 complement(1759489..1761240) 1 NC_012468.1 identified by match to protein family HMM PF00005; match to protein family HMM PF00664; ABC transporter ATP-binding protein 1761240 7684792 SP70585_1893 Streptococcus pneumoniae 70585 ABC transporter ATP-binding protein YP_002741112.1 1759489 R 488221 CDS YP_002741113.1 225859603 7684906 complement(1761230..1762975) 1 NC_012468.1 identified by match to protein family HMM PF00005; match to protein family HMM PF00664; ABC transporter ATP-binding protein 1762975 7684906 SP70585_1894 Streptococcus pneumoniae 70585 ABC transporter ATP-binding protein YP_002741113.1 1761230 R 488221 CDS YP_002741114.1 225859604 7684755 complement(1763181..1763477) 1 NC_012468.1 identified by match to protein family HMM PF04239; hypothetical protein 1763477 7684755 SP70585_1895 Streptococcus pneumoniae 70585 hypothetical protein YP_002741114.1 1763181 R 488221 CDS YP_002741115.1 225859605 7684884 complement(1763630..1763743) 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 1763743 7684884 SP70585_1896 Streptococcus pneumoniae 70585 hypothetical protein YP_002741115.1 1763630 R 488221 CDS YP_002741116.1 225859606 7684459 complement(1763859..1764086) 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 1764086 7684459 SP70585_1897 Streptococcus pneumoniae 70585 hypothetical protein YP_002741116.1 1763859 R 488221 CDS YP_002741117.1 225859607 7683977 1764220..1765047 1 NC_012468.1 identified by match to protein family HMM PF03372; match to protein family HMM TIGR00195; match to protein family HMM TIGR00633; exodeoxyribonuclease III 1765047 xth 7683977 xth Streptococcus pneumoniae 70585 exodeoxyribonuclease III YP_002741117.1 1764220 D 488221 CDS YP_002741118.1 225859608 7683351 1766319..1766900 1 NC_012468.1 Catalyzes the transfer of the phosphoribosyl moiety from 5-phospho--D-ribosyl-1-pyrophosphate (PRib-PP) to the 6-oxo-guanine and -xanthine; xanthine phosphoribosyltransferase 1766900 xpt 7683351 xpt Streptococcus pneumoniae 70585 xanthine phosphoribosyltransferase YP_002741118.1 1766319 D 488221 CDS YP_002741119.1 225859609 7683640 1766900..1768162 1 NC_012468.1 identified by match to protein family HMM PF00860; match to protein family HMM PF00916; match to protein family HMM TIGR00801; match to protein family HMM TIGR03173; xanthine permease 1768162 7683640 SP70585_1902 Streptococcus pneumoniae 70585 xanthine permease YP_002741119.1 1766900 D 488221 CDS YP_002741120.1 225859610 7684367 complement(1768249..1769115) 1 NC_012468.1 identified by match to protein family HMM PF04556; type II restriction enzyme 1769115 7684367 SP70585_1903 Streptococcus pneumoniae 70585 type II restriction enzyme YP_002741120.1 1768249 R 488221 CDS YP_002741121.1 225859611 7684257 complement(1769102..1769872) 1 NC_012468.1 identified by match to protein family HMM PF01555; DNA methylase 1769872 7684257 SP70585_1904 Streptococcus pneumoniae 70585 DNA methylase YP_002741121.1 1769102 R 488221 CDS YP_002741122.1 225859612 7684135 complement(1769898..1770785) 1 NC_012468.1 identified by match to protein family HMM PF02086; match to protein family HMM TIGR00571; modification methylase 1770785 7684135 SP70585_1905 Streptococcus pneumoniae 70585 modification methylase YP_002741122.1 1769898 R 488221 CDS YP_002741123.1 225859613 7683985 complement(1770909..1771313) 1 NC_012468.1 identified by match to protein family HMM PF03061; match to protein family HMM TIGR00369; thioesterase family protein 1771313 7683985 SP70585_1906 Streptococcus pneumoniae 70585 thioesterase family protein YP_002741123.1 1770909 R 488221 CDS YP_002741124.1 225859614 7683577 complement(1771383..1772867) 1 NC_012468.1 catalyzes the formation of alpha-D-glucose 1-phosphate and UDP-galactose from UDP-glucose and alpha-D-galactose 1-phosphate in galactose metabolism; galactose-1-phosphate uridylyltransferase 1772867 galT 7683577 galT Streptococcus pneumoniae 70585 galactose-1-phosphate uridylyltransferase YP_002741124.1 1771383 R 488221 CDS YP_002741125.1 225859615 7683539 complement(1772883..1774061) 1 NC_012468.1 catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase 1774061 galK 7683539 galK Streptococcus pneumoniae 70585 galactokinase YP_002741125.1 1772883 R 488221 CDS YP_002741126.1 225859616 7684486 1774225..1775232 1 NC_012468.1 identified by match to protein family HMM PF00356; match to protein family HMM PF00532; GalR, member of GalR-LacI family of transcriptional regulators, binds DNA; regulator of gal operon 1775232 7684486 SP70585_1909 Streptococcus pneumoniae 70585 GalR, member of GalR-LacI family of transcriptional regulators, binds DNA; regulator of gal operon YP_002741126.1 1774225 D 488221 CDS YP_002741127.1 225859617 7683415 complement(1775279..1776316) 1 NC_012468.1 identified by match to protein family HMM PF00107; match to protein family HMM PF08240; alcohol dehydrogenase, zinc-containing 1776316 7683415 SP70585_1910 Streptococcus pneumoniae 70585 alcohol dehydrogenase, zinc-containing YP_002741127.1 1775279 R 488221 CDS YP_002741128.1 225859618 7684812 complement(1776317..1776670) 1 NC_012468.1 identified by match to protein family HMM PF00376; transcriptional regulator, MerR family 1776670 7684812 SP70585_1911 Streptococcus pneumoniae 70585 transcriptional regulator, MerR family YP_002741128.1 1776317 R 488221 CDS YP_002741129.1 225859619 7683076 complement(1776914..1777804) 1 NC_012468.1 identified by match to protein family HMM PF01545; match to protein family HMM TIGR01297; cation diffusion facilitator transporter - heavy metal transport 1777804 7683076 SP70585_1912 Streptococcus pneumoniae 70585 cation diffusion facilitator transporter - heavy metal transport YP_002741129.1 1776914 R 488221 CDS YP_002741130.1 225859620 7683198 1777937..1778473 1 NC_012468.1 identified by match to protein family HMM PF00440; TetR family transcriptional regulator 1778473 7683198 SP70585_1913 Streptococcus pneumoniae 70585 TetR family transcriptional regulator YP_002741130.1 1777937 D 488221 CDS YP_002741131.1 225859621 7684021 complement(1778639..1779445) 1 NC_012468.1 identified by match to protein family HMM PF04973; match to protein family HMM TIGR01528; nicotinamide mononucleotide transporter 1779445 7684021 SP70585_1914 Streptococcus pneumoniae 70585 nicotinamide mononucleotide transporter YP_002741131.1 1778639 R 488221 CDS YP_002741132.1 225859622 7683601 complement(1779616..1779732) 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 1779732 7683601 SP70585_1915 Streptococcus pneumoniae 70585 hypothetical protein YP_002741132.1 1779616 R 488221 CDS YP_002741133.1 225859623 7683653 complement(1779790..1781310) 1 NC_012468.1 identified by match to protein family HMM PF00528; match to protein family HMM PF04069; choline transporter 1781310 7683653 SP70585_1916 Streptococcus pneumoniae 70585 choline transporter YP_002741133.1 1779790 R 488221 CDS YP_002741134.1 225859624 7683362 complement(1781303..1782031) 1 NC_012468.1 identified by match to protein family HMM PF00005; choline transport ATP-binding protein opuBA 1782031 7683362 SP70585_1917 Streptococcus pneumoniae 70585 choline transport ATP-binding protein opuBA YP_002741134.1 1781303 R 488221 CDS YP_002741135.1 225859625 7684557 complement(1782046..1782810) 1 NC_012468.1 identified by match to protein family HMM PF07366; hypothetical protein 1782810 7684557 SP70585_1918 Streptococcus pneumoniae 70585 hypothetical protein YP_002741135.1 1782046 R 488221 CDS YP_002741136.1 225859626 7684441 complement(1782814..1783257) 1 NC_012468.1 identified by match to protein family HMM PF01047; transcriptional regulator, MarR family 1783257 7684441 SP70585_1919 Streptococcus pneumoniae 70585 transcriptional regulator, MarR family YP_002741136.1 1782814 R 488221 CDS YP_002741137.1 225859627 7684006 complement(1783939..1784235) 1 NC_012468.1 hypothetical protein 1784235 7684006 SP70585_1920 Streptococcus pneumoniae 70585 hypothetical protein YP_002741137.1 1783939 R 488221 CDS YP_002741138.1 225859628 7684383 complement(1784257..1785321) 1 NC_012468.1 identified by match to protein family HMM PF05343; match to protein family HMM TIGR03107; glutamyl aminopeptidase 1785321 pepA 7684383 pepA Streptococcus pneumoniae 70585 glutamyl aminopeptidase YP_002741138.1 1784257 R 488221 CDS YP_002741139.1 225859629 7685136 1785441..1785563 1 NC_012468.1 hypothetical protein 1785563 7685136 SP70585_1922 Streptococcus pneumoniae 70585 hypothetical protein YP_002741139.1 1785441 D 488221 CDS YP_002741140.1 225859630 7684795 1785722..1786423 1 NC_012468.1 identified by match to protein family HMM PF00106; match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF07993; UDP-glucose 4-epimerase (Galactowaldenase) (UDP-galactose4-epimerase) 1786423 7684795 SP70585_1923 Streptococcus pneumoniae 70585 UDP-glucose 4-epimerase (Galactowaldenase) (UDP-galactose4-epimerase) YP_002741140.1 1785722 D 488221 CDS YP_002741141.1 225859631 7683877 1786846..1787805 1 NC_012468.1 identified by match to protein family HMM PF01032; iron-compound ABC transporter permease 1787805 7683877 SP70585_1924 Streptococcus pneumoniae 70585 iron-compound ABC transporter permease YP_002741141.1 1786846 D 488221 CDS YP_002741142.1 225859632 7682976 1787795..1788751 1 NC_012468.1 identified by match to protein family HMM PF01032; iron-compound ABC transporter permease 1788751 7682976 SP70585_1925 Streptococcus pneumoniae 70585 iron-compound ABC transporter permease YP_002741142.1 1787795 D 488221 CDS YP_002741143.1 225859633 7683161 1788748..1789500 1 NC_012468.1 identified by match to protein family HMM PF00005; ferrichrome transport ATP-binding protein FhuC 1789500 7683161 SP70585_1926 Streptococcus pneumoniae 70585 ferrichrome transport ATP-binding protein FhuC YP_002741143.1 1788748 D 488221 CDS YP_002741144.1 225859634 7685078 1789596..1790561 1 NC_012468.1 identified by match to protein family HMM PF01497; iron-compound ABC transporter iron-compound-binding protein 1790561 7685078 SP70585_1927 Streptococcus pneumoniae 70585 iron-compound ABC transporter iron-compound-binding protein YP_002741144.1 1789596 D 488221 CDS YP_002741145.1 225859635 7684332 complement(1790786..1791028) 1 NC_012468.1 identified by match to protein family HMM PF01809; match to protein family HMM TIGR00278; hypothetical protein 1791028 7684332 SP70585_1928 Streptococcus pneumoniae 70585 hypothetical protein YP_002741145.1 1790786 R 488221 CDS YP_002741146.1 225859636 7684579 complement(1791028..1791750) 1 NC_012468.1 identified by match to protein family HMM PF00849; match to protein family HMM PF01479; match to protein family HMM TIGR00093; ribosomal large subunit pseudouridine synthase B 1791750 rluB 7684579 rluB Streptococcus pneumoniae 70585 ribosomal large subunit pseudouridine synthase B YP_002741146.1 1791028 R 488221 CDS YP_002741147.1 225859637 7683654 complement(1791737..1792306) 1 NC_012468.1 functions during chromosome segregation; may form a condensin-like structure with SMC and ScpA; forms a homodimer; segregation and condensation protein B 1792306 scpB 7683654 scpB Streptococcus pneumoniae 70585 segregation and condensation protein B YP_002741147.1 1791737 R 488221 CDS YP_002741148.1 225859638 7684857 complement(1792325..1793053) 1 NC_012468.1 functions during chromosome segregation; may form a condensin-like structure with SMC and ScpB; segregation and condensation protein A 1793053 scpA 7684857 scpA Streptococcus pneumoniae 70585 segregation and condensation protein A YP_002741148.1 1792325 R 488221 CDS YP_002741149.1 225859639 7684858 complement(1793053..1793793) 1 NC_012468.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD-like protein 1793793 xerD 7684858 xerD Streptococcus pneumoniae 70585 site-specific tyrosine recombinase XerD-like protein YP_002741149.1 1793053 R 488221 CDS YP_002741150.1 225859640 7683860 complement(1793784..1794245) 1 NC_012468.1 identified by match to protein family HMM PF00571; CBS domain protein 1794245 7683860 SP70585_1933 Streptococcus pneumoniae 70585 CBS domain protein YP_002741150.1 1793784 R 488221 CDS YP_002741151.1 225859641 7684650 complement(1794242..1794763) 1 NC_012468.1 identified by match to protein family HMM PF00149; match to protein family HMM TIGR00040; phosphodiesterase, family 1794763 7684650 SP70585_1934 Streptococcus pneumoniae 70585 phosphodiesterase, family YP_002741151.1 1794242 R 488221 CDS YP_002741152.1 225859642 7685128 complement(1794739..1795710) 1 NC_012468.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; deoxyribonucleotide triphosphate pyrophosphatase/hypothetical protein 1795710 7685128 SP70585_1935 Streptococcus pneumoniae 70585 deoxyribonucleotide triphosphate pyrophosphatase/hypothetical protein YP_002741152.1 1794739 R 488221 CDS YP_002741153.1 225859643 7683751 complement(1795707..1796501) 1 NC_012468.1 converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 1796501 murI 7683751 murI Streptococcus pneumoniae 70585 glutamate racemase YP_002741153.1 1795707 R 488221 CDS YP_002741154.1 225859644 7684485 complement(1796708..1796956) 1 NC_012468.1 identified by match to protein family HMM PF03672; hypothetical protein 1796956 7684485 SP70585_1937 Streptococcus pneumoniae 70585 hypothetical protein YP_002741154.1 1796708 R 488221 CDS YP_002741155.1 225859645 7684243 complement(1797212..1798837) 1 NC_012468.1 identified by match to protein family HMM PF00128; match to protein family HMM TIGR02403; alpha,alpha-phosphotrehalase 1798837 treC 7684243 treC Streptococcus pneumoniae 70585 alpha,alpha-phosphotrehalase YP_002741155.1 1797212 R 488221 CDS YP_002741156.1 225859646 7684853 complement(1799015..1800982) 1 NC_012468.1 identified by match to protein family HMM PF00358; match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826; match to protein family HMM TIGR00830; match to protein family HMM TIGR01992; pts system, trehalose-specific iibc component 1800982 treP 7684853 treP Streptococcus pneumoniae 70585 pts system, trehalose-specific iibc component YP_002741156.1 1799015 R 488221 CDS YP_002741157.1 225859647 7683935 1801167..1801877 1 NC_012468.1 identified by match to protein family HMM PF00392; match to protein family HMM PF07702; match to protein family HMM TIGR02404; trehalose operon repressor 1801877 treR 7683935 treR Streptococcus pneumoniae 70585 trehalose operon repressor YP_002741157.1 1801167 D 488221 CDS YP_002741158.1 225859648 7684115 1802033..1802551 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase 1802551 7684115 SP70585_1941 Streptococcus pneumoniae 70585 transposase YP_002741158.1 1802033 D 488221 CDS YP_002741159.1 225859649 7682951 1802542..1803318 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01610; transposase 1803318 7682951 SP70585_1942 Streptococcus pneumoniae 70585 transposase YP_002741159.1 1802542 D 488221 CDS YP_002741160.1 225859650 7683217 1803417..1804199 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01610; transposase 1804199 7683217 SP70585_1943 Streptococcus pneumoniae 70585 transposase YP_002741160.1 1803417 D 488221 CDS YP_002741161.1 225859651 7683503 1804196..1804723 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase 1804723 7683503 SP70585_1944 Streptococcus pneumoniae 70585 transposase YP_002741161.1 1804196 D 488221 CDS YP_002741162.1 225859652 7684469 complement(1804857..1805783) 1 NC_012468.1 identified by match to protein family HMM PF00005; match to protein family HMM PF08352; oligopeptide transport ATP-binding protein AmiF 1805783 7684469 SP70585_1945 Streptococcus pneumoniae 70585 oligopeptide transport ATP-binding protein AmiF YP_002741162.1 1804857 R 488221 CDS YP_002741163.1 225859653 7684070 complement(1805794..1806861) 1 NC_012468.1 identified by match to protein family HMM PF00005; match to protein family HMM PF08352; match to protein family HMM TIGR01727; oligopeptide transport ATP-binding protein OppD 1806861 7684070 SP70585_1946 Streptococcus pneumoniae 70585 oligopeptide transport ATP-binding protein OppD YP_002741163.1 1805794 R 488221 CDS YP_002741164.1 225859654 7684166 complement(1806870..1807796) 1 NC_012468.1 identified by match to protein family HMM PF00528; oligopeptide transport system permease AmiD 1807796 7684166 SP70585_1947 Streptococcus pneumoniae 70585 oligopeptide transport system permease AmiD YP_002741164.1 1806870 R 488221 CDS YP_002741165.1 225859655 7682878 complement(1807796..1809292) 1 NC_012468.1 identified by match to protein family HMM PF00528; oligopeptide transport system permease AmiC 1809292 7682878 SP70585_1948 Streptococcus pneumoniae 70585 oligopeptide transport system permease AmiC YP_002741165.1 1807796 R 488221 CDS YP_002741166.1 225859656 7684687 complement(1809359..1811338) 1 NC_012468.1 identified by match to protein family HMM PF00496; AmiA protein 1811338 7684687 SP70585_1949 Streptococcus pneumoniae 70585 AmiA protein YP_002741166.1 1809359 R 488221 CDS YP_002741167.1 225859657 7683039 complement(1812024..1813217) 1 NC_012468.1 identified by match to protein family HMM PF04932; O-antigen polymerase family 1813217 7683039 SP70585_1950 Streptococcus pneumoniae 70585 O-antigen polymerase family YP_002741167.1 1812024 R 488221 CDS YP_002741168.1 225859658 7683465 complement(1813355..1814797) 1 NC_012468.1 identified by match to protein family HMM PF00128; sucrose phosphorylase (Sucrose glucosyltransferase)(Glucosyltransferase-A) (GTF-A) 1814797 7683465 SP70585_1951 Streptococcus pneumoniae 70585 sucrose phosphorylase (Sucrose glucosyltransferase)(Glucosyltransferase-A) (GTF-A) YP_002741168.1 1813355 R 488221 CDS YP_002741169.1 225859659 7684953 complement(1814800..1815009) 1 NC_012468.1 chlorohydrolase 1815009 7684953 SP70585_1952 Streptococcus pneumoniae 70585 chlorohydrolase YP_002741169.1 1814800 R 488221 CDS YP_002741170.1 225859660 7684035 complement(1815016..1815849) 1 NC_012468.1 identified by match to protein family HMM PF00528; sugar ABC transporter permease 1815849 7684035 SP70585_1953 Streptococcus pneumoniae 70585 sugar ABC transporter permease YP_002741170.1 1815016 R 488221 CDS YP_002741171.1 225859661 7684637 complement(1815863..1816729) 1 NC_012468.1 identified by match to protein family HMM PF00528; sugar ABC transporter permease 1816729 7684637 SP70585_1954 Streptococcus pneumoniae 70585 sugar ABC transporter permease YP_002741171.1 1815863 R 488221 CDS YP_002741172.1 225859662 7683078 complement(1816743..1818002) 1 NC_012468.1 identified by match to protein family HMM PF01547; sugar ABC transporter substrate-binding protein 1818002 7683078 SP70585_1955 Streptococcus pneumoniae 70585 sugar ABC transporter substrate-binding protein YP_002741172.1 1816743 R 488221 CDS YP_002741173.1 225859663 7683429 complement(1818037..1820199) 1 NC_012468.1 identified by match to protein family HMM PF02065; alpha-galactosidase AgaN 1820199 7683429 SP70585_1956 Streptococcus pneumoniae 70585 alpha-galactosidase AgaN YP_002741173.1 1818037 R 488221 CDS YP_002741174.1 225859664 7683068 1820307..1821167 1 NC_012468.1 identified by match to protein family HMM PF00165; match to protein family HMM PF02311; Msm operon regulatory protein 1821167 7683068 SP70585_1957 Streptococcus pneumoniae 70585 Msm operon regulatory protein YP_002741174.1 1820307 D 488221 CDS YP_002741175.1 225859665 7684019 1821164..1822099 1 NC_012468.1 catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; biotin--protein ligase 1822099 7684019 SP70585_1958 Streptococcus pneumoniae 70585 biotin--protein ligase YP_002741175.1 1821164 D 488221 CDS YP_002741176.1 225859666 7684709 1822350..1822787 1 NC_012468.1 transposase 1822787 7684709 SP70585_1959 Streptococcus pneumoniae 70585 transposase YP_002741176.1 1822350 D 488221 CDS YP_002741177.1 225859667 7684318 complement(1829703..1831058) 1 NC_012468.1 identified by match to protein family HMM PF01938; match to protein family HMM PF05958; match to protein family HMM TIGR00479; 23S rRNA (uracil-5-)-methyltransferase RumA 1831058 rumA2 7684318 rumA2 Streptococcus pneumoniae 70585 23S rRNA (uracil-5-)-methyltransferase RumA YP_002741177.1 1829703 R 488221 CDS YP_002741178.1 225859668 7684334 1831096..1831872 1 NC_012468.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 1831872 recX 7684334 recX Streptococcus pneumoniae 70585 recombination regulator RecX YP_002741178.1 1831096 D 488221 CDS YP_002741179.1 225859669 7683507 1831961..1832494 1 NC_012468.1 identified by match to protein family HMM PF04167; hypothetical protein 1832494 7683507 SP70585_1984 Streptococcus pneumoniae 70585 hypothetical protein YP_002741179.1 1831961 D 488221 CDS YP_002741180.1 225859670 7683771 complement(1832934..1833260) 1 NC_012468.1 hypothetical protein 1833260 7683771 SP70585_1985 Streptococcus pneumoniae 70585 hypothetical protein YP_002741180.1 1832934 R 488221 CDS YP_002741181.1 225859671 7683387 complement(1833360..1833689) 1 NC_012468.1 hypothetical protein 1833689 7683387 SP70585_1986 Streptococcus pneumoniae 70585 hypothetical protein YP_002741181.1 1833360 R 488221 CDS YP_002741182.1 225859672 7685164 complement(1833827..1835449) 1 NC_012468.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; chaperonin GroEL 1835449 groEL 7685164 groEL Streptococcus pneumoniae 70585 chaperonin GroEL YP_002741182.1 1833827 R 488221 CDS YP_002741183.1 225859673 7684960 complement(1835465..1835749) 1 NC_012468.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 1835749 groES 7684960 groES Streptococcus pneumoniae 70585 co-chaperonin GroES YP_002741183.1 1835465 R 488221 CDS YP_002741184.1 225859674 7683366 complement(1836019..1836414) 1 NC_012468.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein 1836414 7683366 SP70585_1989 Streptococcus pneumoniae 70585 single-stranded DNA-binding protein YP_002741184.1 1836019 R 488221 CDS YP_002741185.1 225859675 7684468 complement(1836492..1837253) 1 NC_012468.1 identified by match to protein family HMM PF00106; match to protein family HMM PF08659; oxidoreductase, short chain dehydrogenase/reductase family 1837253 7684468 SP70585_1990 Streptococcus pneumoniae 70585 oxidoreductase, short chain dehydrogenase/reductase family YP_002741185.1 1836492 R 488221 CDS YP_002741186.1 225859676 7683490 complement(1837286..1837912) 1 NC_012468.1 identified by match to protein family HMM PF01588; Putative tRNA binding domain protein 1837912 7683490 SP70585_1991 Streptococcus pneumoniae 70585 Putative tRNA binding domain protein YP_002741186.1 1837286 R 488221 CDS YP_002741187.1 225859677 7684955 complement(1837928..1838245) 1 NC_012468.1 identified by match to protein family HMM PF00085; thioredoxin family protein 1838245 7684955 SP70585_1992 Streptococcus pneumoniae 70585 thioredoxin family protein YP_002741187.1 1837928 R 488221 CDS YP_002741188.1 225859678 7684164 complement(1838242..1838541) 1 NC_012468.1 hypothetical protein 1838541 7684164 SP70585_1993 Streptococcus pneumoniae 70585 hypothetical protein YP_002741188.1 1838242 R 488221 CDS YP_002741189.1 225859679 7683999 complement(1838826..1838969) 1 NC_012468.1 identified by match to protein family HMM PF01473; hypothetical protein 1838969 7683999 SP70585_1994 Streptococcus pneumoniae 70585 hypothetical protein YP_002741189.1 1838826 R 488221 CDS YP_002741190.1 225859680 7683235 complement(1839178..1839852) 1 NC_012468.1 hypothetical protein 1839852 7683235 SP70585_1995 Streptococcus pneumoniae 70585 hypothetical protein YP_002741190.1 1839178 R 488221 CDS YP_002741191.1 225859681 7682893 complement(1839857..1840303) 1 NC_012468.1 identified by match to protein family HMM PF04397; response regulator of the LytR/AlgR family 1840303 7682893 SP70585_1996 Streptococcus pneumoniae 70585 response regulator of the LytR/AlgR family YP_002741191.1 1839857 R 488221 CDS YP_002741192.1 225859682 7684623 complement(1840417..1840920) 1 NC_012468.1 identified by match to protein family HMM PF01569; PAP2 family protein 1840920 7684623 SP70585_1997 Streptococcus pneumoniae 70585 PAP2 family protein YP_002741192.1 1840417 R 488221 CDS YP_002741193.1 225859683 7683982 complement(1840917..1841279) 1 NC_012468.1 hypothetical protein 1841279 7683982 SP70585_1998 Streptococcus pneumoniae 70585 hypothetical protein YP_002741193.1 1840917 R 488221 CDS YP_002741194.1 225859684 7684041 complement(1841345..1842376) 1 NC_012468.1 identified by match to protein family HMM PF00005; ABC transporter permease 1842376 7684041 SP70585_1999 Streptococcus pneumoniae 70585 ABC transporter permease YP_002741194.1 1841345 R 488221 CDS YP_002741195.1 225859685 7683725 complement(1842383..1843204) 1 NC_012468.1 identified by match to protein family HMM PF00664; ABC transporter permease 1843204 7683725 SP70585_2000 Streptococcus pneumoniae 70585 ABC transporter permease YP_002741195.1 1842383 R 488221 CDS YP_002741196.1 225859686 7683237 complement(1843243..1843569) 1 NC_012468.1 identified by match to protein family HMM PF01047; transcriptional regulator, MarR family 1843569 7683237 SP70585_2001 Streptococcus pneumoniae 70585 transcriptional regulator, MarR family YP_002741196.1 1843243 R 488221 CDS YP_002741197.1 225859687 7683770 complement(1843816..1844532) 1 NC_012468.1 identified by match to protein family HMM PF01709; match to protein family HMM TIGR01033; hypothetical protein 1844532 7683770 SP70585_2002 Streptococcus pneumoniae 70585 hypothetical protein YP_002741197.1 1843816 R 488221 CDS YP_002741198.1 225859688 7683407 complement(1845413..1846828) 1 NC_012468.1 identified by match to protein family HMM PF01289; pneumolysin (Thiol-activated cytolysin) 1846828 7683407 SP70585_2003 Streptococcus pneumoniae 70585 pneumolysin (Thiol-activated cytolysin) YP_002741198.1 1845413 R 488221 CDS YP_002741199.1 225859689 7685047 complement(1846839..1847249) 1 NC_012468.1 hypothetical protein 1847249 7685047 SP70585_2004 Streptococcus pneumoniae 70585 hypothetical protein YP_002741199.1 1846839 R 488221 CDS YP_002741200.1 225859690 7684232 complement(1847242..1847850) 1 NC_012468.1 hypothetical protein 1847850 7684232 SP70585_2005 Streptococcus pneumoniae 70585 hypothetical protein YP_002741200.1 1847242 R 488221 CDS YP_002741201.1 225859691 7683579 complement(1847863..1848321) 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 1848321 7683579 SP70585_2006 Streptococcus pneumoniae 70585 hypothetical protein YP_002741201.1 1847863 R 488221 CDS YP_002741202.1 225859692 7683939 1848446..1848577 1 NC_012468.1 mobile genetic element 1848577 7683939 SP70585_2007 Streptococcus pneumoniae 70585 mobile genetic element YP_002741202.1 1848446 D 488221 CDS YP_002741203.1 225859693 7684132 1848582..1848908 1 NC_012468.1 mobile genetic element 1848908 7684132 SP70585_2008 Streptococcus pneumoniae 70585 mobile genetic element YP_002741203.1 1848582 D 488221 CDS YP_002741204.1 225859694 7682995 complement(1849568..1849828) 1 NC_012468.1 hypothetical protein 1849828 7682995 SP70585_2009 Streptococcus pneumoniae 70585 hypothetical protein YP_002741204.1 1849568 R 488221 CDS YP_002741205.1 225859695 7683660 complement(1849887..1850438) 1 NC_012468.1 hypothetical protein 1850438 7683660 SP70585_2010 Streptococcus pneumoniae 70585 hypothetical protein YP_002741205.1 1849887 R 488221 CDS YP_002741206.1 225859696 7685055 complement(1850428..1850625) 1 NC_012468.1 hypothetical protein 1850625 7685055 SP70585_2011 Streptococcus pneumoniae 70585 hypothetical protein YP_002741206.1 1850428 R 488221 CDS YP_002741207.1 225859697 7683843 complement(1850629..1851213) 1 NC_012468.1 hypothetical protein 1851213 7683843 SP70585_2012 Streptococcus pneumoniae 70585 hypothetical protein YP_002741207.1 1850629 R 488221 CDS YP_002741208.1 225859698 7683780 complement(1851621..1852046) 1 NC_012468.1 hypothetical protein 1852046 7683780 SP70585_2013 Streptococcus pneumoniae 70585 hypothetical protein YP_002741208.1 1851621 R 488221 CDS YP_002741209.1 225859699 7683436 complement(1852175..1852534) 1 NC_012468.1 hypothetical protein 1852534 7683436 SP70585_2014 Streptococcus pneumoniae 70585 hypothetical protein YP_002741209.1 1852175 R 488221 CDS YP_002741210.1 225859700 7683719 complement(1852773..1852934) 1 NC_012468.1 type II restriction-modification system regulatory protein, putative 1852934 7683719 SP70585_2015 Streptococcus pneumoniae 70585 type II restriction-modification system regulatory protein, putative YP_002741210.1 1852773 R 488221 CDS YP_002741211.1 225859701 7684815 complement(1853293..1854249) 1 NC_012468.1 identified by match to protein family HMM PF01473; match to protein family HMM PF01510; autolysin (N-acetylmuramoyl-L-alanine amidase) (Mureinhydrolase) (Mucopeptide aminohydrolase) (Cell wall hydrolase) 1854249 7684815 SP70585_2016 Streptococcus pneumoniae 70585 autolysin (N-acetylmuramoyl-L-alanine amidase) (Mureinhydrolase) (Mucopeptide aminohydrolase) (Cell wall hydrolase) YP_002741211.1 1853293 R 488221 CDS YP_002741212.1 225859702 7683759 complement(1854377..1854490) 1 NC_012468.1 hypothetical protein 1854490 7683759 SP70585_2017 Streptococcus pneumoniae 70585 hypothetical protein YP_002741212.1 1854377 R 488221 CDS YP_002741213.1 225859703 7683425 complement(1854625..1855995) 1 NC_012468.1 identified by match to protein family HMM PF01554; match to protein family HMM TIGR00797; DNA-damage-inducible protein 1855995 7683425 SP70585_2018 Streptococcus pneumoniae 70585 DNA-damage-inducible protein YP_002741213.1 1854625 R 488221 CDS YP_002741214.1 225859704 7684910 complement(1856302..1857468) 1 NC_012468.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A 1857468 recA 7684910 recA Streptococcus pneumoniae 70585 recombinase A YP_002741214.1 1856302 R 488221 CDS YP_002741215.1 225859705 7684072 complement(1857523..1858779) 1 NC_012468.1 identified by match to protein family HMM PF00994; match to protein family HMM PF02464; match to protein family HMM TIGR00199; match to protein family HMM TIGR00200; competence damage-inducible protein A 1858779 7684072 SP70585_2020 Streptococcus pneumoniae 70585 competence damage-inducible protein A YP_002741215.1 1857523 R 488221 CDS YP_002741216.1 225859706 7684601 complement(1858864..1859880) 1 NC_012468.1 identified by match to protein family HMM PF03816; match to protein family HMM TIGR00350; regulator of lytrabc operon 1859880 7684601 SP70585_2021 Streptococcus pneumoniae 70585 regulator of lytrabc operon YP_002741216.1 1858864 R 488221 CDS YP_002741217.1 225859707 7684339 complement(1859888..1860406) 1 NC_012468.1 identified by match to protein family HMM PF00583; acetyltransferase, gnat family 1860406 7684339 SP70585_2022 Streptococcus pneumoniae 70585 acetyltransferase, gnat family YP_002741217.1 1859888 R 488221 CDS YP_002741218.1 225859708 7683354 complement(1860396..1860839) 1 NC_012468.1 identified by match to protein family HMM PF02367; match to protein family HMM TIGR00150; hypothetical protein 1860839 7683354 SP70585_2023 Streptococcus pneumoniae 70585 hypothetical protein YP_002741218.1 1860396 R 488221 CDS YP_002741219.1 225859709 7684413 complement(1860926..1861546) 1 NC_012468.1 lipoprotein, putative 1861546 7684413 SP70585_2024 Streptococcus pneumoniae 70585 lipoprotein, putative YP_002741219.1 1860926 R 488221 CDS YP_002741220.1 225859710 7682969 complement(1861929..1862792) 1 NC_012468.1 identified by match to protein family HMM PF01381; transcriptional activator 1862792 7682969 SP70585_2025 Streptococcus pneumoniae 70585 transcriptional activator YP_002741220.1 1861929 R 488221 CDS YP_002741221.1 225859711 7683868 1862981..1863151 1 NC_012468.1 hypothetical protein 1863151 7683868 SP70585_2026 Streptococcus pneumoniae 70585 hypothetical protein YP_002741221.1 1862981 D 488221 CDS YP_002741222.1 225859712 7684642 1863296..1865311 1 NC_012468.1 identified by match to protein family HMM PF07242; match to protein family HMM TIGR01654; bacteriocin-associated integral membrane protein 1865311 7684642 SP70585_2027 Streptococcus pneumoniae 70585 bacteriocin-associated integral membrane protein YP_002741222.1 1863296 D 488221 CDS YP_002741223.1 225859713 7683087 1865313..1865945 1 NC_012468.1 identified by match to protein family HMM PF00005; antimicrobial peptide ABC transporter ATPase 1865945 7683087 SP70585_2028 Streptococcus pneumoniae 70585 antimicrobial peptide ABC transporter ATPase YP_002741223.1 1865313 D 488221 CDS YP_002741224.1 225859714 7684514 1866086..1866247 1 NC_012468.1 hypothetical protein 1866247 7684514 SP70585_2029 Streptococcus pneumoniae 70585 hypothetical protein YP_002741224.1 1866086 D 488221 CDS YP_002741225.1 225859715 7683532 complement(1866875..1867288) 1 NC_012468.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase 1867288 ndk 7683532 ndk Streptococcus pneumoniae 70585 nucleoside diphosphate kinase YP_002741225.1 1866875 R 488221 CDS YP_002741226.1 225859716 7684333 complement(1867399..1871076) 1 NC_012468.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 1871076 rpoC 7684333 rpoC Streptococcus pneumoniae 70585 DNA-directed RNA polymerase subunit beta' YP_002741226.1 1867399 R 488221 CDS YP_002741227.1 225859717 7684245 complement(1871109..1874705) 1 NC_012468.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 1874705 rpoB 7684245 rpoB Streptococcus pneumoniae 70585 DNA-directed RNA polymerase subunit beta YP_002741227.1 1871109 R 488221 CDS YP_002741228.1 225859718 7683911 complement(1875208..1875327) 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 1875327 7683911 SP70585_2034 Streptococcus pneumoniae 70585 hypothetical protein YP_002741228.1 1875208 R 488221 CDS YP_002741229.1 225859719 7683952 complement(1875389..1876720) 1 NC_012468.1 identified by match to protein family HMM PF00571; match to protein family HMM PF01595; match to protein family HMM PF03471; hemolysin 1876720 7683952 SP70585_2035 Streptococcus pneumoniae 70585 hemolysin YP_002741229.1 1875389 R 488221 CDS YP_002741230.1 225859720 7683544 complement(1876949..1877773) 1 NC_012468.1 identified by match to protein family HMM PF01223; DNA-entry nuclease (Competence-specific nuclease) 1877773 7683544 SP70585_2036 Streptococcus pneumoniae 70585 DNA-entry nuclease (Competence-specific nuclease) YP_002741230.1 1876949 R 488221 CDS YP_002741231.1 225859721 7684209 complement(1877812..1878000) 1 NC_012468.1 hypothetical protein 1878000 7684209 SP70585_2037 Streptococcus pneumoniae 70585 hypothetical protein YP_002741231.1 1877812 R 488221 CDS YP_002741232.1 225859722 7683314 complement(1877993..1879276) 1 NC_012468.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1879276 murA2 7683314 murA2 Streptococcus pneumoniae 70585 UDP-N-acetylglucosamine 1-carboxyvinyltransferase YP_002741232.1 1877993 R 488221 CDS YP_002741233.1 225859723 7684411 complement(1879300..1879431) 1 NC_012468.1 hypothetical protein 1879431 7684411 SP70585_2039 Streptococcus pneumoniae 70585 hypothetical protein YP_002741233.1 1879300 R 488221 CDS YP_002741234.1 225859724 7683261 complement(1879588..1880625) 1 NC_012468.1 ATP-dependent protease La 1880625 7683261 SP70585_2040 Streptococcus pneumoniae 70585 ATP-dependent protease La YP_002741234.1 1879588 R 488221 CDS YP_002741235.1 225859725 7683020 complement(1880609..1881097) 1 NC_012468.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 1881097 coaD 7683020 coaD Streptococcus pneumoniae 70585 phosphopantetheine adenylyltransferase YP_002741235.1 1880609 R 488221 CDS YP_002741236.1 225859726 7684656 complement(1881087..1881626) 1 NC_012468.1 identified by match to protein family HMM PF03602; N6-adenine-specific methylase 1881626 7684656 SP70585_2042 Streptococcus pneumoniae 70585 N6-adenine-specific methylase YP_002741236.1 1881087 R 488221 CDS YP_002741237.1 225859727 7685059 complement(1881691..1882683) 1 NC_012468.1 catalyzes the formation of asparagine from aspartate and ammonia; asparagine synthetase AsnA 1882683 asnA 7685059 asnA Streptococcus pneumoniae 70585 asparagine synthetase AsnA YP_002741237.1 1881691 R 488221 CDS YP_002741238.1 225859728 7684698 complement(1882795..1883478) 1 NC_012468.1 identified by match to protein family HMM PF01027; membrane protein 1883478 7684698 SP70585_2044 Streptococcus pneumoniae 70585 membrane protein YP_002741238.1 1882795 R 488221 CDS YP_002741239.1 225859729 7682962 complement(1883534..1884274) 1 NC_012468.1 identified by match to protein family HMM PF00588; match to protein family HMM PF08032; rRNA/tRNA methylase 1884274 7682962 SP70585_2045 Streptococcus pneumoniae 70585 rRNA/tRNA methylase YP_002741239.1 1883534 R 488221 CDS YP_002741240.1 225859730 7683199 1884308..1884586 1 NC_012468.1 catalyzes the hydrolysis of acylphosphate; acylphosphatase 1884586 7683199 SP70585_2046 Streptococcus pneumoniae 70585 acylphosphatase YP_002741240.1 1884308 D 488221 CDS YP_002741241.1 225859731 7683307 1884664..1885590 1 NC_012468.1 involved in biogenesis of membrane proteins; Firmicutes specific proteins are shorter than other bacterial counterparts and have a signal peptide and lipid attachment site; OxaA-like protein precursor 1885590 7683307 SP70585_2047 Streptococcus pneumoniae 70585 OxaA-like protein precursor YP_002741241.1 1884664 D 488221 CDS YP_002741242.1 225859732 7684756 complement(1885665..1886459) 1 NC_012468.1 identified by match to protein family HMM PF04055; match to protein family HMM TIGR02493; pyruvate formate-lyase 1-activating enzyme 1886459 pflA 7684756 pflA Streptococcus pneumoniae 70585 pyruvate formate-lyase 1-activating enzyme YP_002741242.1 1885665 R 488221 CDS YP_002741243.1 225859733 7684345 complement(1886585..1887835) 1 NC_012468.1 identified by match to protein family HMM PF00278; match to protein family HMM PF02784; diaminopimelate decarboxylase 1887835 7684345 SP70585_2049 Streptococcus pneumoniae 70585 diaminopimelate decarboxylase YP_002741243.1 1886585 R 488221 CDS YP_002741244.1 225859734 7685044 complement(1887902..1888729) 1 NC_012468.1 identified by match to protein family HMM PF00156; match to protein family HMM PF09182; match to protein family HMM TIGR01743; pur operon repressor 1888729 purR 7685044 purR Streptococcus pneumoniae 70585 pur operon repressor YP_002741244.1 1887902 R 488221 CDS YP_002741245.1 225859735 7684692 complement(1888996..1889937) 1 NC_012468.1 identified by match to protein family HMM PF01336; match to protein family HMM PF01966; 3'-5' exoribonuclease YhaM 1889937 7684692 SP70585_2051 Streptococcus pneumoniae 70585 3'-5' exoribonuclease YhaM YP_002741245.1 1888996 R 488221 CDS YP_002741246.1 225859736 7684381 complement(1889927..1891183) 1 NC_012468.1 identified by match to protein family HMM PF02646; competence-induced protein Ccs50 1891183 7684381 SP70585_2052 Streptococcus pneumoniae 70585 competence-induced protein Ccs50 YP_002741246.1 1889927 R 488221 CDS YP_002741247.1 225859737 7684791 complement(1891185..1891847) 1 NC_012468.1 identified by match to protein family HMM PF04263; match to protein family HMM PF04265; match to protein family HMM TIGR01378; thiamine pyrophosphokinase 1891847 7684791 SP70585_2053 Streptococcus pneumoniae 70585 thiamine pyrophosphokinase YP_002741247.1 1891185 R 488221 CDS YP_002741248.1 225859738 7685139 complement(1891810..1892466) 1 NC_012468.1 identified by match to protein family HMM PF00834; match to protein family HMM TIGR01163; ribulose-phosphate 3-epimerase 1892466 rpe 7685139 rpe Streptococcus pneumoniae 70585 ribulose-phosphate 3-epimerase YP_002741248.1 1891810 R 488221 CDS YP_002741249.1 225859739 7684077 complement(1892477..1893355) 1 NC_012468.1 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity; ribosome-associated GTPase 1893355 rsgA 7684077 rsgA Streptococcus pneumoniae 70585 ribosome-associated GTPase YP_002741249.1 1892477 R 488221 CDS YP_002741250.1 225859740 7683668 complement(1893357..1894229) 1 NC_012468.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 1894229 ksgA 7683668 ksgA Streptococcus pneumoniae 70585 dimethyladenosine transferase YP_002741250.1 1893357 R 488221 CDS YP_002741251.1 225859741 7683509 complement(1894480..1894773) 1 NC_012468.1 hypothetical protein 1894773 7683509 SP70585_2057 Streptococcus pneumoniae 70585 hypothetical protein YP_002741251.1 1894480 R 488221 CDS YP_002741252.1 225859742 7683804 complement(1894766..1895407) 1 NC_012468.1 identified by match to protein family HMM PF00005; antimicrobial peptide ABC transporter ATPase 1895407 7683804 SP70585_2058 Streptococcus pneumoniae 70585 antimicrobial peptide ABC transporter ATPase YP_002741252.1 1894766 R 488221 CDS YP_002741253.1 225859743 7685165 complement(1895409..1897439) 1 NC_012468.1 identified by match to protein family HMM PF07242; match to protein family HMM TIGR01654; immunity protein, putative 1897439 7685165 SP70585_2059 Streptococcus pneumoniae 70585 immunity protein, putative YP_002741253.1 1895409 R 488221 CDS YP_002741254.1 225859744 7683954 complement(1897516..1897812) 1 NC_012468.1 identified by match to protein family HMM TIGR01653; bacteriocin, lactococcin 972 family 1897812 7683954 SP70585_2060 Streptococcus pneumoniae 70585 bacteriocin, lactococcin 972 family YP_002741254.1 1897516 R 488221 CDS YP_002741255.1 225859745 7684997 complement(1898132..1899031) 1 NC_012468.1 transcriptional activator 1899031 7684997 SP70585_2061 Streptococcus pneumoniae 70585 transcriptional activator YP_002741255.1 1898132 R 488221 CDS YP_002741256.1 225859746 7684889 complement(1899103..1899663) 1 NC_012468.1 identified by match to protein family HMM PF01751; match to protein family HMM TIGR00334; putative primase homolog 1899663 7684889 SP70585_2062 Streptococcus pneumoniae 70585 putative primase homolog YP_002741256.1 1899103 R 488221 CDS YP_002741257.1 225859747 7684515 complement(1899663..1900436) 1 NC_012468.1 identified by match to protein family HMM PF01026; match to protein family HMM TIGR00010; deoxyribonuclease TatD family 1900436 7684515 SP70585_2063 Streptococcus pneumoniae 70585 deoxyribonuclease TatD family YP_002741257.1 1899663 R 488221 CDS YP_002741258.1 225859748 7683477 complement(1900742..1901407) 1 NC_012468.1 identified by match to protein family HMM PF00746; match to protein family HMM TIGR01167; cell wall surface anchor family protein 1901407 7683477 SP70585_2064 Streptococcus pneumoniae 70585 cell wall surface anchor family protein YP_002741258.1 1900742 R 488221 CDS YP_002741259.1 225859749 7684179 complement(1901670..1901804) 1 NC_012468.1 in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 1901804 rpmH 7684179 rpmH Streptococcus pneumoniae 70585 50S ribosomal protein L34 YP_002741259.1 1901670 R 488221 CDS YP_002741260.1 225859750 7683334 complement(1901949..1903163) 1 NC_012468.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase AlaT 1903163 7683334 SP70585_2066 Streptococcus pneumoniae 70585 aminotransferase AlaT YP_002741260.1 1901949 R 488221 CDS YP_002741261.1 225859751 7684523 complement(1903319..1903612) 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 1903612 7684523 SP70585_2067 Streptococcus pneumoniae 70585 hypothetical protein YP_002741261.1 1903319 R 488221 CDS YP_002741262.1 225859752 7683392 1903774..1904226 1 NC_012468.1 identified by match to protein family HMM PF00582; universal stress protein family 1904226 7683392 SP70585_2068 Streptococcus pneumoniae 70585 universal stress protein family YP_002741262.1 1903774 D 488221 CDS YP_002741263.1 225859753 7684597 complement(1904261..1905649) 1 NC_012468.1 identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; Cof family protein 1905649 7684597 SP70585_2069 Streptococcus pneumoniae 70585 Cof family protein YP_002741263.1 1904261 R 488221 CDS YP_002741264.1 225859754 7685014 1905715..1906677 1 NC_012468.1 identified by match to protein family HMM PF00710; L-asparaginase 1906677 7685014 SP70585_2070 Streptococcus pneumoniae 70585 L-asparaginase YP_002741264.1 1905715 D 488221 CDS YP_002741265.1 225859755 7683817 complement(1906706..1907044) 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 1907044 7683817 SP70585_2071 Streptococcus pneumoniae 70585 hypothetical protein YP_002741265.1 1906706 R 488221 CDS YP_002741266.1 225859756 7683357 complement(1907108..1908118) 1 NC_012468.1 identified by match to protein family HMM PF00356; match to protein family HMM PF00532; match to protein family HMM TIGR01481; catabolite control protein A 1908118 ccpA 7683357 ccpA Streptococcus pneumoniae 70585 catabolite control protein A YP_002741266.1 1907108 R 488221 CDS YP_002741267.1 225859757 7684422 complement(1908543..1909142) 1 NC_012468.1 identified by match to protein family HMM PF00072; match to protein family HMM PF00196; response regulator 1909142 7684422 SP70585_2073 Streptococcus pneumoniae 70585 response regulator YP_002741267.1 1908543 R 488221 CDS YP_002741268.1 225859758 7684576 complement(1909144..1910241) 1 NC_012468.1 identified by match to protein family HMM PF02518; match to protein family HMM PF07730; histidine kinase 1910241 7684576 SP70585_2074 Streptococcus pneumoniae 70585 histidine kinase YP_002741268.1 1909144 R 488221 CDS YP_002741269.1 225859759 7684837 complement(1910241..1910978) 1 NC_012468.1 identified by match to protein family HMM PF01061; multidrug ABC transporter permease 1910978 7684837 SP70585_2075 Streptococcus pneumoniae 70585 multidrug ABC transporter permease YP_002741269.1 1910241 R 488221 CDS YP_002741270.1 225859760 7685141 complement(1910980..1911864) 1 NC_012468.1 identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1911864 7685141 SP70585_2076 Streptococcus pneumoniae 70585 ABC transporter ATP-binding protein YP_002741270.1 1910980 R 488221 CDS YP_002741271.1 225859761 7684089 complement(1911851..1912045) 1 NC_012468.1 hypothetical protein 1912045 7684089 SP70585_2077 Streptococcus pneumoniae 70585 hypothetical protein YP_002741271.1 1911851 R 488221 CDS YP_002741272.1 225859762 7682965 complement(1912042..1912248) 1 NC_012468.1 hypothetical protein 1912248 7682965 SP70585_2078 Streptococcus pneumoniae 70585 hypothetical protein YP_002741272.1 1912042 R 488221 CDS YP_002741273.1 225859763 7683909 complement(1918928..1919407) 1 NC_012468.1 competence-specific global transcription modulator 1919407 7683909 SP70585_2093 Streptococcus pneumoniae 70585 competence-specific global transcription modulator YP_002741273.1 1918928 R 488221 CDS YP_002741274.1 225859764 7685185 complement(1919529..1920065) 1 NC_012468.1 Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 1920065 nusG 7685185 nusG Streptococcus pneumoniae 70585 transcription antitermination protein NusG YP_002741274.1 1919529 R 488221 CDS YP_002741275.1 225859765 7684654 complement(1920120..1920296) 1 NC_012468.1 forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 1920296 secE 7684654 secE Streptococcus pneumoniae 70585 preprotein translocase subunit SecE YP_002741275.1 1920120 R 488221 CDS YP_002741276.1 225859766 7683088 complement(1920306..1920458) 1 NC_012468.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group have the CXXC motif; 50S ribosomal protein L33 1920458 rpmG 7683088 rpmG Streptococcus pneumoniae 70585 50S ribosomal protein L33 YP_002741276.1 1920306 R 488221 CDS YP_002741277.1 225859767 7685067 complement(1920511..1922706) 1 NC_012468.1 identified by match to protein family HMM PF00905; match to protein family HMM PF00912; match to protein family HMM TIGR02074; penicillin-binding protein 2A 1922706 7685067 SP70585_2097 Streptococcus pneumoniae 70585 penicillin-binding protein 2A YP_002741277.1 1920511 R 488221 CDS YP_002741278.1 225859768 7684152 1922832..1923668 1 NC_012468.1 identified by match to protein family HMM PF00849; ribosomal large subunit pseudouridine synthase, RluD subfamily 1923668 7684152 SP70585_2098 Streptococcus pneumoniae 70585 ribosomal large subunit pseudouridine synthase, RluD subfamily YP_002741278.1 1922832 D 488221 CDS YP_002741279.1 225859769 7683090 complement(1923736..1924743) 1 NC_012468.1 identified by match to protein family HMM PF00044; match to protein family HMM PF02800; match to protein family HMM TIGR01534; glyceraldehyde-3-phosphate dehydrogenase, type I 1924743 gap 7683090 gap Streptococcus pneumoniae 70585 glyceraldehyde-3-phosphate dehydrogenase, type I YP_002741279.1 1923736 R 488221 CDS YP_002741280.1 225859770 7683468 complement(1924920..1925882) 1 NC_012468.1 identified by match to protein family HMM PF02687; efflux ABC transporter permease 1925882 7683468 SP70585_2100 Streptococcus pneumoniae 70585 efflux ABC transporter permease YP_002741280.1 1924920 R 488221 CDS YP_002741281.1 225859771 7683732 complement(1925943..1926125) 1 NC_012468.1 transposase 1926125 7683732 SP70585_2101 Streptococcus pneumoniae 70585 transposase YP_002741281.1 1925943 R 488221 CDS YP_002741282.1 225859772 7684037 complement(1926460..1926789) 1 NC_012468.1 identified by match to protein family HMM PF01710; transposase 1926789 7684037 SP70585_2102 Streptococcus pneumoniae 70585 transposase YP_002741282.1 1926460 R 488221 CDS YP_002741283.1 225859773 7683623 complement(1926920..1927792) 1 NC_012468.1 catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; nicotinate-nucleotide pyrophosphorylase 1927792 nadC 7683623 nadC Streptococcus pneumoniae 70585 nicotinate-nucleotide pyrophosphorylase YP_002741283.1 1926920 R 488221 CDS YP_002741284.1 225859774 7683625 1928029..1929339 1 NC_012468.1 identified by match to protein family HMM PF03600; match to protein family HMM PF07158; membrane protein 1929339 7683625 SP70585_2104 Streptococcus pneumoniae 70585 membrane protein YP_002741284.1 1928029 D 488221 CDS YP_002741285.1 225859775 7684567 complement(1929705..1929836) 1 NC_012468.1 hypothetical protein 1929836 7684567 SP70585_2105 Streptococcus pneumoniae 70585 hypothetical protein YP_002741285.1 1929705 R 488221 CDS YP_002741286.1 225859776 7683859 complement(1930360..1931088) 1 NC_012468.1 identified by match to protein family HMM PF00392; match to protein family HMM PF07702; GntR family transcriptional regulator 1931088 7683859 SP70585_2106 Streptococcus pneumoniae 70585 GntR family transcriptional regulator YP_002741286.1 1930360 R 488221 CDS YP_002741287.1 225859777 7684865 1931246..1932655 1 NC_012468.1 identified by match to protein family HMM PF00232; beta-glucosidase 1932655 7684865 SP70585_2107 Streptococcus pneumoniae 70585 beta-glucosidase YP_002741287.1 1931246 D 488221 CDS YP_002741288.1 225859778 7684234 1932673..1933968 1 NC_012468.1 identified by match to protein family HMM PF02378; match to protein family HMM TIGR00410; phosphotransferase system system, cellobiose-specific IIC component 1933968 7684234 SP70585_2108 Streptococcus pneumoniae 70585 phosphotransferase system system, cellobiose-specific IIC component YP_002741288.1 1932673 D 488221 CDS YP_002741289.1 225859779 7684034 1933973..1934281 1 NC_012468.1 identified by match to protein family HMM PF02302; lichenan-specific phosphotransferase enzyme iib component (pts system lichenan-specific eiib component) (eiib-lic) 1934281 7684034 SP70585_2109 Streptococcus pneumoniae 70585 lichenan-specific phosphotransferase enzyme iib component (pts system lichenan-specific eiib component) (eiib-lic) YP_002741289.1 1933973 D 488221 CDS YP_002741290.1 225859780 7683676 1934278..1934586 1 NC_012468.1 identified by match to protein family HMM PF02255; lichenan-specific phosphotransferase enzyme iia component (pts system lichenan-specific eiia component) (eiia-lic) (eiii-lic) 1934586 7683676 SP70585_2110 Streptococcus pneumoniae 70585 lichenan-specific phosphotransferase enzyme iia component (pts system lichenan-specific eiia component) (eiia-lic) (eiii-lic) YP_002741290.1 1934278 D 488221 CDS YP_002741291.1 225859781 7682992 complement(1935572..1938223) 1 NC_012468.1 identified by match to protein family HMM PF00465; bifunctional acetaldehyde-CoA/alcohol dehydrogenase 1938223 7682992 SP70585_2111 Streptococcus pneumoniae 70585 bifunctional acetaldehyde-CoA/alcohol dehydrogenase YP_002741291.1 1935572 R 488221 CDS YP_002741292.1 225859782 7683535 complement(1938426..1938563) 1 NC_012468.1 hypothetical protein 1938563 7683535 SP70585_2112 Streptococcus pneumoniae 70585 hypothetical protein YP_002741292.1 1938426 R 488221 CDS YP_002741293.1 225859783 7683889 complement(1938523..1938933) 1 NC_012468.1 identified by match to protein family HMM PF02493; morn motif family protein 1938933 7683889 SP70585_2113 Streptococcus pneumoniae 70585 morn motif family protein YP_002741293.1 1938523 R 488221 CDS YP_002741294.1 225859784 7683424 complement(1938935..1939363) 1 NC_012468.1 identified by match to protein family HMM PF01451; phosphotyrosine protein phosphatase 1939363 7683424 SP70585_2114 Streptococcus pneumoniae 70585 phosphotyrosine protein phosphatase YP_002741294.1 1938935 R 488221 CDS YP_002741295.1 225859785 7683641 complement(1939410..1939709) 1 NC_012468.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC 1939709 yajC 7683641 yajC Streptococcus pneumoniae 70585 preprotein translocase subunit YajC YP_002741295.1 1939410 R 488221 CDS YP_002741296.1 225859786 7685012 complement(1939820..1941802) 1 NC_012468.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 1941802 tkt2 7685012 tkt2 Streptococcus pneumoniae 70585 transketolase YP_002741296.1 1939820 R 488221 CDS YP_002741297.1 225859787 7684534 complement(1941916..1943007) 1 NC_012468.1 putative L-ascorbate 6-phosphate lactonase 1943007 7684534 SP70585_2117 Streptococcus pneumoniae 70585 putative L-ascorbate 6-phosphate lactonase YP_002741297.1 1941916 R 488221 CDS YP_002741298.1 225859788 7684022 complement(1943119..1944792) 1 NC_012468.1 identified by match to protein family HMM PF00874; match to protein family HMM PF08279; transcriptional regulator, BglG family 1944792 7684022 SP70585_2118 Streptococcus pneumoniae 70585 transcriptional regulator, BglG family YP_002741298.1 1943119 R 488221 CDS YP_002741299.1 225859789 7684221 complement(1944969..1945673) 1 NC_012468.1 catalyzes the formation of D-xylulose 5-phosphate from L-ribulose 5-phosphate in the L-arabinose and L-ascorbate degradation pathways; L-ribulose-5-phosphate 4-epimerase 1945673 araD 7684221 araD Streptococcus pneumoniae 70585 L-ribulose-5-phosphate 4-epimerase YP_002741299.1 1944969 R 488221 CDS YP_002741300.1 225859790 7683452 complement(1945675..1946538) 1 NC_012468.1 L-xylulose 5-phosphate 3-epimerase activity not yet demonstrated; may be involved in the utilization of 2,3-diketo-L-gulonate; putative L-xylulose 5-phosphate 3-epimerase 1946538 7683452 SP70585_2120 Streptococcus pneumoniae 70585 putative L-xylulose 5-phosphate 3-epimerase YP_002741300.1 1945675 R 488221 CDS YP_002741301.1 225859791 7684466 complement(1946542..1947207) 1 NC_012468.1 catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization; 3-keto-L-gulonate-6-phosphate decarboxylase 1947207 ulaD 7684466 ulaD Streptococcus pneumoniae 70585 3-keto-L-gulonate-6-phosphate decarboxylase YP_002741301.1 1946542 R 488221 CDS YP_002741302.1 225859792 7684455 complement(1947224..1947709) 1 NC_012468.1 identified by match to protein family HMM PF00359; ascorbate-specific phosphotransferase enzyme iia component (pts system ascorbate-specific eiia component) 1947709 7684455 SP70585_2122 Streptococcus pneumoniae 70585 ascorbate-specific phosphotransferase enzyme iia component (pts system ascorbate-specific eiia component) YP_002741302.1 1947224 R 488221 CDS YP_002741303.1 225859793 7683278 complement(1947786..1948067) 1 NC_012468.1 identified by match to protein family HMM PF02302; ascorbate-specific phosphotransferase enzyme iib component (ascorbate-specific pts system eiib component) 1948067 7683278 SP70585_2123 Streptococcus pneumoniae 70585 ascorbate-specific phosphotransferase enzyme iib component (ascorbate-specific pts system eiib component) YP_002741303.1 1947786 R 488221 CDS YP_002741304.1 225859794 7683037 complement(1948090..1949547) 1 NC_012468.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC 1949547 7683037 SP70585_2124 Streptococcus pneumoniae 70585 PTS system ascorbate-specific transporter subunit IIC YP_002741304.1 1948090 R 488221 CDS YP_002741305.1 225859795 7683758 complement(1949678..1950301) 1 NC_012468.1 hypothetical protein 1950301 7683758 SP70585_2125 Streptococcus pneumoniae 70585 hypothetical protein YP_002741305.1 1949678 R 488221 CDS YP_002741306.1 225859796 7683341 complement(1950352..1951338) 1 NC_012468.1 identified by match to protein family HMM PF01424; jag protein 1951338 7683341 SP70585_2126 Streptococcus pneumoniae 70585 jag protein YP_002741306.1 1950352 R 488221 CDS YP_002741307.1 225859797 7683852 complement(1951357..1952187) 1 NC_012468.1 identified by match to protein family HMM PF02096; membrane protein OxaA 1 1952187 7683852 SP70585_2127 Streptococcus pneumoniae 70585 membrane protein OxaA 1 YP_002741307.1 1951357 R 488221 CDS YP_002741308.1 225859798 7684767 complement(1952156..1952527) 1 NC_012468.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 1952527 rnpA 7684767 rnpA Streptococcus pneumoniae 70585 ribonuclease P YP_002741308.1 1952156 R 488221 CDS YP_002741309.1 225859799 7683588 complement(1952544..1952675) 1 NC_012468.1 hypothetical protein 1952675 7683588 SP70585_2129 Streptococcus pneumoniae 70585 hypothetical protein YP_002741309.1 1952544 R 488221 CDS YP_002741310.1 225859800 7683182 complement(1952676..1953866) 1 NC_012468.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 1953866 ackA 7683182 ackA Streptococcus pneumoniae 70585 acetate kinase YP_002741310.1 1952676 R 488221 CDS YP_002741311.1 225859801 7685132 complement(1953917..1954870) 1 NC_012468.1 adenine-specific DNA methylase 1954870 7685132 SP70585_2131 Streptococcus pneumoniae 70585 adenine-specific DNA methylase YP_002741311.1 1953917 R 488221 CDS YP_002741312.1 225859802 7684958 1955294..1955596 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; mobile genetic element 1955596 7684958 SP70585_2132 Streptococcus pneumoniae 70585 mobile genetic element YP_002741312.1 1955294 D 488221 CDS YP_002741313.1 225859803 7682988 1955630..1955914 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; mobile genetic element 1955914 7682988 SP70585_2133 Streptococcus pneumoniae 70585 mobile genetic element YP_002741313.1 1955630 D 488221 CDS YP_002741314.1 225859804 7684829 1956169..1956645 1 NC_012468.1 identified by match to protein family HMM PF00583; acetyltransferase 1956645 7684829 SP70585_2134 Streptococcus pneumoniae 70585 acetyltransferase YP_002741314.1 1956169 D 488221 CDS YP_002741315.1 225859805 7683956 complement(1957300..1957713) 1 NC_012468.1 hypothetical protein 1957713 7683956 SP70585_2135 Streptococcus pneumoniae 70585 hypothetical protein YP_002741315.1 1957300 R 488221 CDS YP_002741316.1 225859806 7683302 complement(1957691..1958152) 1 NC_012468.1 competence protein ComGF 1958152 7683302 SP70585_2136 Streptococcus pneumoniae 70585 competence protein ComGF YP_002741316.1 1957691 R 488221 CDS YP_002741317.1 225859807 7684739 complement(1958115..1958375) 1 NC_012468.1 hypothetical protein 1958375 7684739 SP70585_2137 Streptococcus pneumoniae 70585 hypothetical protein YP_002741317.1 1958115 R 488221 CDS YP_002741318.1 225859808 7684677 complement(1958380..1958766) 1 NC_012468.1 competence protein CglD 1958766 7684677 SP70585_2138 Streptococcus pneumoniae 70585 competence protein CglD YP_002741318.1 1958380 R 488221 CDS YP_002741319.1 225859809 7684045 complement(1958777..1959100) 1 NC_012468.1 identified by match to protein family HMM PF07963; match to protein family HMM TIGR02532; competence protein 1959100 7684045 SP70585_2139 Streptococcus pneumoniae 70585 competence protein YP_002741319.1 1958777 R 488221 CDS YP_002741320.1 225859810 7683232 complement(1959102..1959950) 1 NC_012468.1 identified by match to protein family HMM PF00482; competence protein CglB 1959950 7683232 SP70585_2140 Streptococcus pneumoniae 70585 competence protein CglB YP_002741320.1 1959102 R 488221 CDS YP_002741321.1 225859811 7683091 complement(1960066..1961007) 1 NC_012468.1 identified by match to protein family HMM PF00437; putative ABC transporter subunit ComYA 1961007 7683091 SP70585_2141 Streptococcus pneumoniae 70585 putative ABC transporter subunit ComYA YP_002741321.1 1960066 R 488221 CDS YP_002741322.1 225859812 7683648 complement(1961083..1961448) 1 NC_012468.1 identified by match to protein family HMM PF06279; hypothetical protein 1961448 7683648 SP70585_2142 Streptococcus pneumoniae 70585 hypothetical protein YP_002741322.1 1961083 R 488221 CDS YP_002741323.1 225859813 7684429 complement(1961599..1962657) 1 NC_012468.1 identified by match to protein family HMM PF00107; match to protein family HMM PF08240; alcohol dehydrogenase, zinc-containing 1962657 7684429 SP70585_2143 Streptococcus pneumoniae 70585 alcohol dehydrogenase, zinc-containing YP_002741323.1 1961599 R 488221 CDS YP_002741324.1 225859814 7684933 complement(1962820..1963971) 1 NC_012468.1 identified by match to protein family HMM PF01979; match to protein family HMM TIGR00221; N-acetylglucosamine-6-phosphate deacetylase 1963971 nagA 7684933 nagA Streptococcus pneumoniae 70585 N-acetylglucosamine-6-phosphate deacetylase YP_002741324.1 1962820 R 488221 CDS YP_002741325.1 225859815 7684874 complement(1964124..1965941) 1 NC_012468.1 identified by match to protein family HMM PF01757; acyltransferase 1965941 7684874 SP70585_2145 Streptococcus pneumoniae 70585 acyltransferase YP_002741325.1 1964124 R 488221 CDS YP_002741326.1 225859816 7684218 1965934..1966059 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 1966059 7684218 SP70585_2147 Streptococcus pneumoniae 70585 hypothetical protein YP_002741326.1 1965934 D 488221 CDS YP_002741327.1 225859817 7685042 complement(1966042..1967184) 1 NC_012468.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase 1967184 tgt 7685042 tgt Streptococcus pneumoniae 70585 queuine tRNA-ribosyltransferase YP_002741327.1 1966042 R 488221 CDS YP_002741328.1 225859818 7684670 1967314..1968171 1 NC_012468.1 identified by match to protein family HMM PF06161; hypothetical protein 1968171 7684670 SP70585_2148 Streptococcus pneumoniae 70585 hypothetical protein YP_002741328.1 1967314 D 488221 CDS YP_002741329.1 225859819 7683019 complement(1968949..1969308) 1 NC_012468.1 identified by match to protein family HMM PF06993; hypothetical protein 1969308 7683019 SP70585_2151 Streptococcus pneumoniae 70585 hypothetical protein YP_002741329.1 1968949 R 488221 CDS YP_002741330.1 225859820 7685184 complement(1969319..1969744) 1 NC_012468.1 identified by match to protein family HMM PF01022; match to protein family HMM PF01047; transcriptional regulator, MarR family 1969744 7685184 SP70585_2152 Streptococcus pneumoniae 70585 transcriptional regulator, MarR family YP_002741330.1 1969319 R 488221 CDS YP_002741331.1 225859821 7684181 complement(1970067..1971179) 1 NC_012468.1 identified by match to protein family HMM PF01476; LysM domain-containing protein 1971179 7684181 SP70585_2153 Streptococcus pneumoniae 70585 LysM domain-containing protein YP_002741331.1 1970067 R 488221 CDS YP_002741332.1 225859822 7683636 complement(1971982..1973262) 1 NC_012468.1 identified by match to protein family HMM PF01554; match to protein family HMM PF03023; match to protein family HMM TIGR00797; multi antimicrobial extrusion 1973262 7683636 SP70585_2156 Streptococcus pneumoniae 70585 multi antimicrobial extrusion YP_002741332.1 1971982 R 488221 CDS YP_002741333.1 225859823 7684032 complement(1973323..1974807) 1 NC_012468.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 1974807 thrC 7684032 thrC Streptococcus pneumoniae 70585 threonine synthase YP_002741333.1 1973323 R 488221 CDS YP_002741334.1 225859824 7684231 complement(1974883..1976160) 1 NC_012468.1 hypothetical protein 1976160 7684231 SP70585_2158 Streptococcus pneumoniae 70585 hypothetical protein YP_002741334.1 1974883 R 488221 CDS YP_002741335.1 225859825 7683896 complement(1982623..1983057) 1 NC_012468.1 cytidine/deoxycytidylate deaminase family protein 1983057 7683896 SP70585_2175 Streptococcus pneumoniae 70585 cytidine/deoxycytidylate deaminase family protein YP_002741335.1 1982623 R 488221 CDS YP_002741336.1 225859826 7683173 complement(1983071..1984531) 1 NC_012468.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 1984531 gltX 7683173 gltX Streptococcus pneumoniae 70585 glutamyl-tRNA synthetase YP_002741336.1 1983071 R 488221 CDS YP_002741337.1 225859827 7683695 complement(1984655..1986004) 1 NC_012468.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 1986004 pgi 7683695 pgi Streptococcus pneumoniae 70585 glucose-6-phosphate isomerase YP_002741337.1 1984655 R 488221 CDS YP_002741338.1 225859828 7683537 complement(1985991..1986170) 1 NC_012468.1 hypothetical protein 1986170 7683537 SP70585_2178 Streptococcus pneumoniae 70585 hypothetical protein YP_002741338.1 1985991 R 488221 CDS YP_002741339.1 225859829 7684543 complement(1986174..1986863) 1 NC_012468.1 identified by match to protein family HMM PF00117; match to protein family HMM PF07722; glutamine amidotransferase 1986863 7684543 SP70585_2179 Streptococcus pneumoniae 70585 glutamine amidotransferase YP_002741339.1 1986174 R 488221 CDS YP_002741340.1 225859830 7683949 complement(1987001..1988767) 1 NC_012468.1 identified by match to protein family HMM PF00005; match to protein family HMM PF00664; ABC transporter ATP-binding protein/permease 1988767 7683949 SP70585_2180 Streptococcus pneumoniae 70585 ABC transporter ATP-binding protein/permease YP_002741340.1 1987001 R 488221 CDS YP_002741341.1 225859831 7684661 1988920..1989228 1 NC_012468.1 transposase 1989228 7684661 SP70585_2181 Streptococcus pneumoniae 70585 transposase YP_002741341.1 1988920 D 488221 CDS YP_002741342.1 225859832 7684210 complement(1989558..1991252) 1 NC_012468.1 identified by match to protein family HMM PF00005; match to protein family HMM PF00664; ABC transporter ATP-binding protein/permease 1991252 7684210 SP70585_2182 Streptococcus pneumoniae 70585 ABC transporter ATP-binding protein/permease YP_002741342.1 1989558 R 488221 CDS YP_002741343.1 225859833 7683590 complement(1991399..1993933) 1 NC_012468.1 This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS 1993933 mutS 7683590 mutS Streptococcus pneumoniae 70585 DNA mismatch repair protein MutS YP_002741343.1 1991399 R 488221 CDS YP_002741344.1 225859834 7683493 complement(1993984..1994430) 1 NC_012468.1 identified by match to protein family HMM PF01316; match to protein family HMM PF02863; match to protein family HMM TIGR01529; arginine repressor 1994430 argR 7683493 argR Streptococcus pneumoniae 70585 arginine repressor YP_002741344.1 1993984 R 488221 CDS YP_002741345.1 225859835 7683671 1994566..1996257 1 NC_012468.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 1996257 argS 7683671 argS Streptococcus pneumoniae 70585 arginyl-tRNA synthetase YP_002741345.1 1994566 D 488221 CDS YP_002741346.1 225859836 7682932 complement(1996572..1996961) 1 NC_012468.1 identified by match to protein family HMM PF01609; transposase (IS4 family) 1996961 7682932 SP70585_2186 Streptococcus pneumoniae 70585 transposase (IS4 family) YP_002741346.1 1996572 R 488221 CDS YP_002741347.1 225859837 7683790 1997115..1997600 1 NC_012468.1 identified by match to protein family HMM PF06172; hypothetical protein 1997600 7683790 SP70585_2187 Streptococcus pneumoniae 70585 hypothetical protein YP_002741347.1 1997115 D 488221 CDS YP_002741348.1 225859838 7683933 1997684..1998391 1 NC_012468.1 identified by match to protein family HMM PF00072; match to protein family HMM PF00486; alkaline phosphatase synthesis transcriptional regulatory proteinphoP 1998391 7683933 SP70585_2188 Streptococcus pneumoniae 70585 alkaline phosphatase synthesis transcriptional regulatory proteinphoP YP_002741348.1 1997684 D 488221 CDS YP_002741349.1 225859839 7685176 1998392..1999723 1 NC_012468.1 identified by match to protein family HMM PF00512; match to protein family HMM PF02518; histidine kinase PnpS 1999723 7685176 SP70585_2189 Streptococcus pneumoniae 70585 histidine kinase PnpS YP_002741349.1 1998392 D 488221 CDS YP_002741350.1 225859840 7683300 1999890..2000765 1 NC_012468.1 ABC transporter substrate-binding protein - phosphate transport 2000765 7683300 SP70585_2190 Streptococcus pneumoniae 70585 ABC transporter substrate-binding protein - phosphate transport YP_002741350.1 1999890 D 488221 CDS YP_002741351.1 225859841 7684591 2000883..2001746 1 NC_012468.1 identified by match to protein family HMM PF00528; match to protein family HMM TIGR02138; phosphate ABC transporter permease 2001746 pstC2 7684591 pstC2 Streptococcus pneumoniae 70585 phosphate ABC transporter permease YP_002741351.1 2000883 D 488221 CDS YP_002741352.1 225859842 7683597 2001739..2002554 1 NC_012468.1 identified by match to protein family HMM PF00528; match to protein family HMM TIGR00974; phosphate ABC transporter permease 2002554 pstA2 7683597 pstA2 Streptococcus pneumoniae 70585 phosphate ABC transporter permease YP_002741352.1 2001739 D 488221 CDS YP_002741353.1 225859843 7683200 2002556..2003308 1 NC_012468.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein 2003308 pstB3 7683200 pstB3 Streptococcus pneumoniae 70585 phosphate transporter ATP-binding protein YP_002741353.1 2002556 D 488221 CDS YP_002741354.1 225859844 7685146 2003323..2003973 1 NC_012468.1 identified by match to protein family HMM PF01895; match to protein family HMM TIGR02135; phosphate transport system regulatory protein PhoU 2003973 phoU2 7685146 phoU2 Streptococcus pneumoniae 70585 phosphate transport system regulatory protein PhoU YP_002741354.1 2003323 D 488221 CDS YP_002741355.1 225859845 7685194 2004041..2004475 1 NC_012468.1 transposase, IS1380-Spn1 related, truncation 2004475 7685194 SP70585_2195 Streptococcus pneumoniae 70585 transposase, IS1380-Spn1 related, truncation YP_002741355.1 2004041 D 488221 CDS YP_002741356.1 225859846 7683383 2005215..2006231 1 NC_012468.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 2006231 gpsA 7683383 gpsA Streptococcus pneumoniae 70585 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase YP_002741356.1 2005215 D 488221 CDS YP_002741357.1 225859847 7684100 2006253..2007152 1 NC_012468.1 identified by match to protein family HMM PF00483; match to protein family HMM TIGR01099; UTP-glucose-1-phosphate uridylyltransferase 2007152 galU 7684100 galU Streptococcus pneumoniae 70585 UTP-glucose-1-phosphate uridylyltransferase YP_002741357.1 2006253 D 488221 CDS YP_002741358.1 225859848 7684505 complement(2007447..2007638) 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 2007638 7684505 SP70585_2199 Streptococcus pneumoniae 70585 hypothetical protein YP_002741358.1 2007447 R 488221 CDS YP_002741359.1 225859849 7685071 complement(2007652..2008329) 1 NC_012468.1 identified by match to protein family HMM PF01694; peptidase, S54 2008329 7685071 SP70585_2200 Streptococcus pneumoniae 70585 peptidase, S54 YP_002741359.1 2007652 R 488221 CDS YP_002741360.1 225859850 7683213 complement(2008313..2008852) 1 NC_012468.1 identified by match to protein family HMM PF01812; match to protein family HMM TIGR02727; 5-formyltetrahydrofolate cyclo-ligase 2008852 7683213 SP70585_2201 Streptococcus pneumoniae 70585 5-formyltetrahydrofolate cyclo-ligase YP_002741360.1 2008313 R 488221 CDS YP_002741361.1 225859851 7683782 complement(2008864..2009994) 1 NC_012468.1 identified by match to protein family HMM PF01546; match to protein family HMM PF07687; match to protein family HMM TIGR01891; peptidase, M20/M25/M40 family 2009994 7683782 SP70585_2202 Streptococcus pneumoniae 70585 peptidase, M20/M25/M40 family YP_002741361.1 2008864 R 488221 CDS YP_002741362.1 225859852 7684615 complement(2010062..2010760) 1 NC_012468.1 identified by match to protein family HMM PF00132; match to protein family HMM PF08503; galactoside O-acetyltransferase 2010760 7684615 SP70585_2203 Streptococcus pneumoniae 70585 galactoside O-acetyltransferase YP_002741362.1 2010062 R 488221 CDS YP_002741363.1 225859853 7683847 complement(2010990..2011901) 1 NC_012468.1 identified by match to protein family HMM PF00892; membrane protein 2011901 7683847 SP70585_2204 Streptococcus pneumoniae 70585 membrane protein YP_002741363.1 2010990 R 488221 CDS YP_002741364.1 225859854 7683434 complement(2011966..2014428) 1 NC_012468.1 identified by match to protein family HMM PF00905; match to protein family HMM PF00912; penicillin-binding protein 1B 2014428 7683434 SP70585_2205 Streptococcus pneumoniae 70585 penicillin-binding protein 1B YP_002741364.1 2011966 R 488221 CDS YP_002741365.1 225859855 7684452 2014570..2015826 1 NC_012468.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 2015826 tyrS 7684452 tyrS Streptococcus pneumoniae 70585 tyrosyl-tRNA synthetase YP_002741365.1 2014570 D 488221 CDS YP_002741366.1 225859856 7683364 complement(2015904..2017967) 1 NC_012468.1 identified by match to protein family HMM PF00122; match to protein family HMM PF00702; match to protein family HMM TIGR01494; match to protein family HMM TIGR01525; P-type ATPase-metal/cation transport 2017967 7683364 SP70585_2207 Streptococcus pneumoniae 70585 P-type ATPase-metal/cation transport YP_002741366.1 2015904 R 488221 CDS YP_002741367.1 225859857 7684828 complement(2017969..2018247) 1 NC_012468.1 hypothetical protein 2018247 7684828 SP70585_2208 Streptococcus pneumoniae 70585 hypothetical protein YP_002741367.1 2017969 R 488221 CDS YP_002741368.1 225859858 7683546 2018399..2019247 1 NC_012468.1 identified by match to protein family HMM PF08241; 23S rRNA m1G745 methyltransferase 2019247 7683546 SP70585_2209 Streptococcus pneumoniae 70585 23S rRNA m1G745 methyltransferase YP_002741368.1 2018399 D 488221 CDS YP_002741369.1 225859859 7683241 2020070..2020642 1 NC_012468.1 hypothetical protein 2020642 7683241 SP70585_2210 Streptococcus pneumoniae 70585 hypothetical protein YP_002741369.1 2020070 D 488221 CDS YP_002741370.1 225859860 7682909 complement(2021687..2023945) 1 NC_012468.1 identified by match to protein family HMM PF00343; match to protein family HMM TIGR02093; glycogen phosphorylase 2023945 7682909 SP70585_2211 Streptococcus pneumoniae 70585 glycogen phosphorylase YP_002741370.1 2021687 R 488221 CDS YP_002741371.1 225859861 7684684 complement(2023971..2025488) 1 NC_012468.1 amylomaltase; acts to release glucose from maltodextrins; 4-alpha-glucanotransferase 2025488 malQ 7684684 malQ Streptococcus pneumoniae 70585 4-alpha-glucanotransferase YP_002741371.1 2023971 R 488221 CDS YP_002741372.1 225859862 7683948 2026038..2027309 1 NC_012468.1 identified by match to protein family HMM PF01547; maltose/maltodextrin-binding protein 2027309 7683948 SP70585_2213 Streptococcus pneumoniae 70585 maltose/maltodextrin-binding protein YP_002741372.1 2026038 D 488221 CDS YP_002741373.1 225859863 7684674 2027420..2028712 1 NC_012468.1 identified by match to protein family HMM PF00528; match to protein family HMM PF05154; maltodextrin transport system permease MalC 2028712 7684674 SP70585_2214 Streptococcus pneumoniae 70585 maltodextrin transport system permease MalC YP_002741373.1 2027420 D 488221 CDS YP_002741374.1 225859864 7682921 2028714..2029556 1 NC_012468.1 identified by match to protein family HMM PF00528; maltose/maltodextrin ABC transporter permease 2029556 7682921 SP70585_2215 Streptococcus pneumoniae 70585 maltose/maltodextrin ABC transporter permease YP_002741374.1 2028714 D 488221 CDS YP_002741375.1 225859865 7684406 2029809..2030609 1 NC_012468.1 maltodextrose utilization protein MalA 2030609 7684406 SP70585_2216 Streptococcus pneumoniae 70585 maltodextrose utilization protein MalA YP_002741375.1 2029809 D 488221 CDS YP_002741376.1 225859866 7683481 2030619..2031605 1 NC_012468.1 identified by match to protein family HMM PF00356; match to protein family HMM PF00532; HTH-type transcriptional regulator MalR (Maltose operontranscriptional repressor) 2031605 7683481 SP70585_2217 Streptococcus pneumoniae 70585 HTH-type transcriptional regulator MalR (Maltose operontranscriptional repressor) YP_002741376.1 2030619 D 488221 CDS YP_002741377.1 225859867 7683840 2031672..2031995 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 2031995 7683840 SP70585_2218 Streptococcus pneumoniae 70585 hypothetical protein YP_002741377.1 2031672 D 488221 CDS YP_002741378.1 225859868 7683221 complement(2032031..2032972) 1 NC_012468.1 identified by match to protein family HMM PF02588; YitT family protein 2032972 7683221 SP70585_2219 Streptococcus pneumoniae 70585 YitT family protein YP_002741378.1 2032031 R 488221 CDS YP_002741379.1 225859869 7683793 complement(2032950..2034713) 1 NC_012468.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase 2034713 aspS 7683793 aspS Streptococcus pneumoniae 70585 aspartyl-tRNA synthetase YP_002741379.1 2032950 R 488221 CDS YP_002741380.1 225859870 7685040 complement(2034832..2035005) 1 NC_012468.1 chlorohydrolase 2035005 7685040 SP70585_2221 Streptococcus pneumoniae 70585 chlorohydrolase YP_002741380.1 2034832 R 488221 CDS YP_002741381.1 225859871 7683972 complement(2035110..2035340) 1 NC_012468.1 hypothetical protein 2035340 7683972 SP70585_2222 Streptococcus pneumoniae 70585 hypothetical protein YP_002741381.1 2035110 R 488221 CDS YP_002741382.1 225859872 7685024 complement(2035358..2035999) 1 NC_012468.1 identified by match to protein family HMM PF02517; caax amino protease family 2035999 7685024 SP70585_2223 Streptococcus pneumoniae 70585 caax amino protease family YP_002741382.1 2035358 R 488221 CDS YP_002741383.1 225859873 7684669 complement(2036011..2036745) 1 NC_012468.1 hypothetical protein 2036745 7684669 SP70585_2224 Streptococcus pneumoniae 70585 hypothetical protein YP_002741383.1 2036011 R 488221 CDS YP_002741384.1 225859874 7683100 complement(2036748..2036945) 1 NC_012468.1 hypothetical protein 2036945 7683100 SP70585_2225 Streptococcus pneumoniae 70585 hypothetical protein YP_002741384.1 2036748 R 488221 CDS YP_002741385.1 225859875 7684328 complement(2036945..2037151) 1 NC_012468.1 identified by match to protein family HMM PF01381; hypothetical protein 2037151 7684328 SP70585_2226 Streptococcus pneumoniae 70585 hypothetical protein YP_002741385.1 2036945 R 488221 CDS YP_002741386.1 225859876 7684056 complement(2037161..2037475) 1 NC_012468.1 hypothetical protein 2037475 7684056 SP70585_2227 Streptococcus pneumoniae 70585 hypothetical protein YP_002741386.1 2037161 R 488221 CDS YP_002741387.1 225859877 7684862 complement(2037429..2037581) 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 2037581 7684862 SP70585_2228 Streptococcus pneumoniae 70585 hypothetical protein YP_002741387.1 2037429 R 488221 CDS YP_002741388.1 225859878 7684491 complement(2037625..2037753) 1 NC_012468.1 chlorohydrolase 2037753 7684491 SP70585_2229 Streptococcus pneumoniae 70585 chlorohydrolase YP_002741388.1 2037625 R 488221 CDS YP_002741389.1 225859879 7684128 complement(2037813..2039102) 1 NC_012468.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase 2039102 hisS 7684128 hisS Streptococcus pneumoniae 70585 histidyl-tRNA synthetase YP_002741389.1 2037813 R 488221 CDS YP_002741390.1 225859880 7685120 complement(2041327..2043051) 1 NC_012468.1 identified by match to protein family HMM PF00933; beta-N-acetylglucosaminidase/beta-glucosidase (3-beta-N-acetyl-D-glucosaminidase/beta-D- glucosidase)(Nag3) 2043051 7685120 SP70585_2233 Streptococcus pneumoniae 70585 beta-N-acetylglucosaminidase/beta-glucosidase (3-beta-N-acetyl-D-glucosaminidase/beta-D- glucosidase)(Nag3) YP_002741390.1 2041327 R 488221 CDS YP_002741391.1 225859881 7683881 complement(2043062..2044852) 1 NC_012468.1 identified by match to protein family HMM PF00933; beta-N-acetylglucosaminidase/beta-glucosidase (3-beta-N-acetyl-D-glucosaminidase/beta-D- glucosidase)(Nag3) 2044852 7683881 SP70585_2234 Streptococcus pneumoniae 70585 beta-N-acetylglucosaminidase/beta-glucosidase (3-beta-N-acetyl-D-glucosaminidase/beta-D- glucosidase)(Nag3) YP_002741391.1 2043062 R 488221 CDS YP_002741392.1 225859882 7684066 complement(2044899..2045696) 1 NC_012468.1 phosphoglycolate phosphatase 2045696 7684066 SP70585_2235 Streptococcus pneumoniae 70585 phosphoglycolate phosphatase YP_002741392.1 2044899 R 488221 CDS YP_002741393.1 225859883 7684458 complement(2045699..2046538) 1 NC_012468.1 Converts D-mannonate to D-mannuronate; D-mannonate oxidoreductase 2046538 7684458 SP70585_2236 Streptococcus pneumoniae 70585 D-mannonate oxidoreductase YP_002741393.1 2045699 R 488221 CDS YP_002741394.1 225859884 7683489 complement(2046541..2047641) 1 NC_012468.1 catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate; mannonate dehydratase 2047641 uxuA 7683489 uxuA Streptococcus pneumoniae 70585 mannonate dehydratase YP_002741394.1 2046541 R 488221 CDS YP_002741395.1 225859885 7683940 complement(2047655..2049055) 1 NC_012468.1 catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism; glucuronate isomerase 2049055 uxaC 7683940 uxaC Streptococcus pneumoniae 70585 glucuronate isomerase YP_002741395.1 2047655 R 488221 CDS YP_002741396.1 225859886 7685149 complement(2049057..2049677) 1 NC_012468.1 identified by match to protein family HMM PF01081; match to protein family HMM TIGR01182; khg/kdpg aldolase 2049677 7685149 SP70585_2239 Streptococcus pneumoniae 70585 khg/kdpg aldolase YP_002741396.1 2049057 R 488221 CDS YP_002741397.1 225859887 7684487 complement(2049800..2050516) 1 NC_012468.1 identified by match to protein family HMM PF00392; match to protein family HMM PF07729; GntR family transcriptional regulator 2050516 7684487 SP70585_2240 Streptococcus pneumoniae 70585 GntR family transcriptional regulator YP_002741397.1 2049800 R 488221 CDS YP_002741398.1 225859888 7683375 complement(2050562..2052361) 1 NC_012468.1 identified by match to protein family HMM PF00703; match to protein family HMM PF02836; match to protein family HMM PF02837; beta-D-glucuronidase 2052361 7683375 SP70585_2241 Streptococcus pneumoniae 70585 beta-D-glucuronidase YP_002741398.1 2050562 R 488221 CDS YP_002741399.1 225859889 7684180 complement(2052376..2053404) 1 NC_012468.1 identified by match to protein family HMM PF00294; sugar kinase, ribokinase family 2053404 7684180 SP70585_2242 Streptococcus pneumoniae 70585 sugar kinase, ribokinase family YP_002741399.1 2052376 R 488221 CDS YP_002741400.1 225859890 7684891 complement(2053480..2055033) 1 NC_012468.1 sugar/sodium symporter 2055033 7684891 SP70585_2243 Streptococcus pneumoniae 70585 sugar/sodium symporter YP_002741400.1 2053480 R 488221 CDS YP_002741401.1 225859891 7683453 complement(2055220..2055537) 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 2055537 7683453 SP70585_2244 Streptococcus pneumoniae 70585 hypothetical protein YP_002741401.1 2055220 R 488221 CDS YP_002741402.1 225859892 7683215 complement(2055598..2056155) 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 2056155 7683215 SP70585_2245 Streptococcus pneumoniae 70585 hypothetical protein YP_002741402.1 2055598 R 488221 CDS YP_002741403.1 225859893 7682898 complement(2056185..2056376) 1 NC_012468.1 hypothetical protein 2056376 7682898 SP70585_2246 Streptococcus pneumoniae 70585 hypothetical protein YP_002741403.1 2056185 R 488221 CDS YP_002741404.1 225859894 7683628 complement(2056419..2057648) 1 NC_012468.1 hypothetical protein 2057648 7683628 SP70585_2247 Streptococcus pneumoniae 70585 hypothetical protein YP_002741404.1 2056419 R 488221 CDS YP_002741405.1 225859895 7684435 complement(2057839..2058600) 1 NC_012468.1 identified by match to protein family HMM TIGR01716; positive transcriptional regulator of glucosyltransferase and Spp phenotype 2058600 7684435 SP70585_2248 Streptococcus pneumoniae 70585 positive transcriptional regulator of glucosyltransferase and Spp phenotype YP_002741405.1 2057839 R 488221 CDS YP_002741406.1 225859896 7683730 complement(2058665..2058799) 1 NC_012468.1 hypothetical protein 2058799 7683730 SP70585_2249 Streptococcus pneumoniae 70585 hypothetical protein YP_002741406.1 2058665 R 488221 CDS YP_002741407.1 225859897 7682900 2058814..2059155 1 NC_012468.1 identified by match to protein family HMM PF01883; hypothetical protein 2059155 7682900 SP70585_2250 Streptococcus pneumoniae 70585 hypothetical protein YP_002741407.1 2058814 D 488221 CDS YP_002741408.1 225859898 7683082 2059219..2059428 1 NC_012468.1 chlorohydrolase 2059428 7683082 SP70585_2251 Streptococcus pneumoniae 70585 chlorohydrolase YP_002741408.1 2059219 D 488221 CDS YP_002741409.1 225859899 7683192 complement(2059454..2061157) 1 NC_012468.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase 2061157 ilvD 7683192 ilvD Streptococcus pneumoniae 70585 dihydroxy-acid dehydratase YP_002741409.1 2059454 R 488221 CDS YP_002741410.1 225859900 7685102 complement(2061390..2062322) 1 NC_012468.1 identified by match to protein family HMM PF02779; match to protein family HMM PF02780; transketolase, C- subunit 2062322 7685102 SP70585_2253 Streptococcus pneumoniae 70585 transketolase, C- subunit YP_002741410.1 2061390 R 488221 CDS YP_002741411.1 225859901 7683712 complement(2062319..2063176) 1 NC_012468.1 identified by match to protein family HMM PF00456; transketolase, thiamine disphosphate-binding subunit 2063176 7683712 SP70585_2254 Streptococcus pneumoniae 70585 transketolase, thiamine disphosphate-binding subunit YP_002741411.1 2062319 R 488221 CDS YP_002741412.1 225859902 7683134 complement(2063180..2064526) 1 NC_012468.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC 2064526 ulaA 7683134 ulaA Streptococcus pneumoniae 70585 PTS system ascorbate-specific transporter subunit IIC YP_002741412.1 2063180 R 488221 CDS YP_002741413.1 225859903 7683012 complement(2064539..2064823) 1 NC_012468.1 identified by match to protein family HMM PF02302; phosphotransferase system, galactitol-specific IIB component 2064823 7683012 SP70585_2256 Streptococcus pneumoniae 70585 phosphotransferase system, galactitol-specific IIB component YP_002741413.1 2064539 R 488221 CDS YP_002741414.1 225859904 7683812 complement(2064827..2066857) 1 NC_012468.1 identified by match to protein family HMM PF00359; match to protein family HMM PF00874; transcriptional regulator, BglG family protein 2066857 7683812 SP70585_2257 Streptococcus pneumoniae 70585 transcriptional regulator, BglG family protein YP_002741414.1 2064827 R 488221 CDS YP_002741415.1 225859905 7683796 2067049..2068056 1 NC_012468.1 identified by match to protein family HMM PF01145; integral membrane protein 2068056 7683796 SP70585_2258 Streptococcus pneumoniae 70585 integral membrane protein YP_002741415.1 2067049 D 488221 CDS YP_002741416.1 225859906 7684174 2068059..2068259 1 NC_012468.1 hypothetical protein 2068259 7684174 SP70585_2259 Streptococcus pneumoniae 70585 hypothetical protein YP_002741416.1 2068059 D 488221 CDS YP_002741417.1 225859907 7685003 2068411..2068593 1 NC_012468.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 2068593 rpmF 7685003 rpmF Streptococcus pneumoniae 70585 50S ribosomal protein L32 YP_002741417.1 2068411 D 488221 CDS YP_002741418.1 225859908 7683741 2068609..2068758 1 NC_012468.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 2068758 rpmG 7683741 rpmG Streptococcus pneumoniae 70585 50S ribosomal protein L33 YP_002741418.1 2068609 D 488221 CDS YP_002741419.1 225859909 7684619 complement(2069238..2071163) 1 NC_012468.1 identified by match to protein family HMM PF01473; choline binding protein PcpA 2071163 7684619 SP70585_2262 Streptococcus pneumoniae 70585 choline binding protein PcpA YP_002741419.1 2069238 R 488221 CDS YP_002741420.1 225859910 7685092 2071498..2071680 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by glimmer; putative; hypothetical protein 2071680 7685092 SP70585_2263 Streptococcus pneumoniae 70585 hypothetical protein YP_002741420.1 2071498 D 488221 CDS YP_002741421.1 225859911 7683675 2072041..2072187 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase B 2072187 7683675 SP70585_2265 Streptococcus pneumoniae 70585 transposase B YP_002741421.1 2072041 D 488221 CDS YP_002741422.1 225859912 7685111 2072194..2072430 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; mobile genetic element 2072430 7685111 SP70585_2266 Streptococcus pneumoniae 70585 mobile genetic element YP_002741422.1 2072194 D 488221 CDS YP_002741423.1 225859913 7683284 complement(2072514..2072654) 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 2072654 7683284 SP70585_2267 Streptococcus pneumoniae 70585 hypothetical protein YP_002741423.1 2072514 R 488221 CDS YP_002741424.1 225859914 7684573 complement(2072669..2072800) 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 2072800 7684573 SP70585_2268 Streptococcus pneumoniae 70585 hypothetical protein YP_002741424.1 2072669 R 488221 CDS YP_002741425.1 225859915 7683347 complement(2073067..2074947) 1 NC_012468.1 identified by match to protein family HMM PF00728; N-acetyl-beta-D-glucosaminidase 2074947 7683347 SP70585_2269 Streptococcus pneumoniae 70585 N-acetyl-beta-D-glucosaminidase YP_002741425.1 2073067 R 488221 CDS YP_002741426.1 225859916 7684095 complement(2074941..2075810) 1 NC_012468.1 identified by match to protein family HMM PF00480; ROK family protein 2075810 7684095 SP70585_2270 Streptococcus pneumoniae 70585 ROK family protein YP_002741426.1 2074941 R 488221 CDS YP_002741427.1 225859917 7683350 complement(2075894..2078539) 1 NC_012468.1 identified by match to protein family HMM PF01074; match to protein family HMM PF07748; glycosyl hydrolase, family 38 2078539 7683350 SP70585_2271 Streptococcus pneumoniae 70585 glycosyl hydrolase, family 38 YP_002741427.1 2075894 R 488221 CDS YP_002741428.1 225859918 7684091 complement(2078630..2079910) 1 NC_012468.1 identified by match to protein family HMM PF06824; hypothetical protein 2079910 7684091 SP70585_2272 Streptococcus pneumoniae 70585 hypothetical protein YP_002741428.1 2078630 R 488221 CDS YP_002741429.1 225859919 7685020 2080081..2082165 1 NC_012468.1 identified by match to protein family HMM PF07971; match to protein family HMM TIGR01180; antigen, cell wall surface anchor family 2082165 7685020 SP70585_2273 Streptococcus pneumoniae 70585 antigen, cell wall surface anchor family YP_002741429.1 2080081 D 488221 CDS YP_002741430.1 225859920 7684845 complement(2082205..2083884) 1 NC_012468.1 identified by match to protein family HMM PF00754; putative alpha-L-fucosidase 1 (Alpha-L-fucoside fucohydrolase) 2083884 7684845 SP70585_2274 Streptococcus pneumoniae 70585 putative alpha-L-fucosidase 1 (Alpha-L-fucoside fucohydrolase) YP_002741430.1 2082205 R 488221 CDS YP_002741431.1 225859921 7685155 2084639..2085868 1 NC_012468.1 catalyzes the degradation of arginine to citruline and ammonia; arginine deiminase 2085868 arcA 7685155 arcA Streptococcus pneumoniae 70585 arginine deiminase YP_002741431.1 2084639 D 488221 CDS YP_002741432.1 225859922 7684425 2085926..2086942 1 NC_012468.1 catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway; ornithine carbamoyltransferase 2086942 argF 7684425 argF Streptococcus pneumoniae 70585 ornithine carbamoyltransferase YP_002741432.1 2085926 D 488221 CDS YP_002741433.1 225859923 7684735 2087107..2088054 1 NC_012468.1 catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase 2088054 arcC 7684735 arcC Streptococcus pneumoniae 70585 carbamate kinase YP_002741433.1 2087107 D 488221 CDS YP_002741434.1 225859924 7683299 2088265..2089776 1 NC_012468.1 identified by match to protein family HMM PF03606; arginine-ornithine antiporter 2089776 7683299 SP70585_2278 Streptococcus pneumoniae 70585 arginine-ornithine antiporter YP_002741434.1 2088265 D 488221 CDS YP_002741435.1 225859925 7683480 2089798..2091129 1 NC_012468.1 identified by match to protein family HMM PF01546; match to protein family HMM TIGR01887; hypothetical protein 2091129 7683480 SP70585_2279 Streptococcus pneumoniae 70585 hypothetical protein YP_002741435.1 2089798 D 488221 CDS YP_002741436.1 225859926 7683731 complement(2091811..2092077) 1 NC_012468.1 identified by match to protein family HMM PF04650; match to protein family HMM TIGR01168; gram-positive signal peptide, ysirk family protein 2092077 7683731 SP70585_2280 Streptococcus pneumoniae 70585 gram-positive signal peptide, ysirk family protein YP_002741436.1 2091811 R 488221 CDS YP_002741437.1 225859927 7683142 2092266..2092469 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 2092469 7683142 SP70585_2281 Streptococcus pneumoniae 70585 hypothetical protein YP_002741437.1 2092266 D 488221 CDS YP_002741438.1 225859928 7684832 complement(2092506..2093405) 1 NC_012468.1 identified by match to protein family HMM PF01145; spfh domain/band 7 family 2093405 7684832 SP70585_2282 Streptococcus pneumoniae 70585 spfh domain/band 7 family YP_002741438.1 2092506 R 488221 CDS YP_002741439.1 225859929 7684707 complement(2093535..2094686) 1 NC_012468.1 identified by match to protein family HMM PF00465; NAD-dependent methanol dehydrogenase (medh) 2094686 7684707 SP70585_2283 Streptococcus pneumoniae 70585 NAD-dependent methanol dehydrogenase (medh) YP_002741439.1 2093535 R 488221 CDS YP_002741440.1 225859930 7683059 complement(2094832..2096598) 1 NC_012468.1 catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose; L-fucose isomerase 2096598 fucI 7683059 fucI Streptococcus pneumoniae 70585 L-fucose isomerase YP_002741440.1 2094832 R 488221 CDS YP_002741441.1 225859931 7685035 complement(2096611..2097339) 1 NC_012468.1 identified by match to protein family HMM PF00596; L-fuculose phosphate aldolase 2097339 7685035 SP70585_2285 Streptococcus pneumoniae 70585 L-fuculose phosphate aldolase YP_002741441.1 2096611 R 488221 CDS YP_002741442.1 225859932 7684726 complement(2097354..2100371) 1 NC_012468.1 identified by match to protein family HMM PF08305; blood group A- and B-cleaving endo-beta-galactosidase 2100371 7684726 SP70585_2286 Streptococcus pneumoniae 70585 blood group A- and B-cleaving endo-beta-galactosidase YP_002741442.1 2097354 R 488221 CDS YP_002741443.1 225859933 7683738 complement(2100382..2102598) 1 NC_012468.1 identified by match to protein family HMM PF02065; alpha-galactosidase AgaN 2102598 7683738 SP70585_2287 Streptococcus pneumoniae 70585 alpha-galactosidase AgaN YP_002741443.1 2100382 R 488221 CDS YP_002741444.1 225859934 7683437 complement(2102620..2104491) 1 NC_012468.1 F5/8 type C domain containing protein 2104491 7683437 SP70585_2288 Streptococcus pneumoniae 70585 F5/8 type C domain containing protein YP_002741444.1 2102620 R 488221 CDS YP_002741445.1 225859935 7684025 complement(2104497..2105816) 1 NC_012468.1 identified by match to protein family HMM PF01120; alpha-L-fucosidase 2105816 7684025 SP70585_2289 Streptococcus pneumoniae 70585 alpha-L-fucosidase YP_002741445.1 2104497 R 488221 CDS YP_002741446.1 225859936 7684207 complement(2105813..2106652) 1 NC_012468.1 identified by match to protein family HMM PF00528; sugar ABC transporter permease 2106652 7684207 SP70585_2290 Streptococcus pneumoniae 70585 sugar ABC transporter permease YP_002741446.1 2105813 R 488221 CDS YP_002741447.1 225859937 7685095 complement(2106655..2107584) 1 NC_012468.1 identified by match to protein family HMM PF00528; sugar ABC transporter permease 2107584 7685095 SP70585_2291 Streptococcus pneumoniae 70585 sugar ABC transporter permease YP_002741447.1 2106655 R 488221 CDS YP_002741448.1 225859938 7684192 complement(2107672..2108964) 1 NC_012468.1 identified by match to protein family HMM PF01547; extracellular solute-binding protein 2108964 7684192 SP70585_2292 Streptococcus pneumoniae 70585 extracellular solute-binding protein YP_002741448.1 2107672 R 488221 CDS YP_002741449.1 225859939 7684448 complement(2108994..2110397) 1 NC_012468.1 identified by match to protein family HMM PF00370; rhamnulokinase (Rhamnulose kinase) 2110397 7684448 SP70585_2293 Streptococcus pneumoniae 70585 rhamnulokinase (Rhamnulose kinase) YP_002741449.1 2108994 R 488221 CDS YP_002741450.1 225859940 7683615 2110573..2111346 1 NC_012468.1 identified by match to protein family HMM PF00455; match to protein family HMM PF08220; match to protein family HMM PF08279; regulator of fucose operon 2111346 7683615 SP70585_2294 Streptococcus pneumoniae 70585 regulator of fucose operon YP_002741450.1 2110573 D 488221 CDS YP_002741451.1 225859941 7682929 complement(2112474..2113979) 1 NC_012468.1 identified by match to protein family HMM PF01297; match to protein family HMM PF09223; zinc-binding lipoprotein AdcA 2113979 7682929 SP70585_2295 Streptococcus pneumoniae 70585 zinc-binding lipoprotein AdcA YP_002741451.1 2112474 R 488221 CDS YP_002741452.1 225859942 7683283 complement(2113989..2114795) 1 NC_012468.1 identified by match to protein family HMM PF00950; zinc ABC transporter permease 2114795 7683283 SP70585_2296 Streptococcus pneumoniae 70585 zinc ABC transporter permease YP_002741452.1 2113989 R 488221 CDS YP_002741453.1 225859943 7683122 complement(2114788..2115492) 1 NC_012468.1 identified by match to protein family HMM PF00005; zinc transport system ATP-binding protein AdcC 2115492 7683122 SP70585_2297 Streptococcus pneumoniae 70585 zinc transport system ATP-binding protein AdcC YP_002741453.1 2114788 R 488221 CDS YP_002741454.1 225859944 7684120 complement(2115492..2115932) 1 NC_012468.1 identified by match to protein family HMM PF01022; match to protein family HMM PF01047; match to protein family HMM PF01325; match to protein family HMM PF01978; match to protein family HMM PF08279; putative transcriptional repressor 2115932 7684120 SP70585_2298 Streptococcus pneumoniae 70585 putative transcriptional repressor YP_002741454.1 2115492 R 488221 CDS YP_002741455.1 225859945 7684544 2115917..2116054 1 NC_012468.1 hypothetical protein 2116054 7684544 SP70585_2299 Streptococcus pneumoniae 70585 hypothetical protein YP_002741455.1 2115917 D 488221 CDS YP_002741456.1 225859946 7684613 complement(2116087..2117355) 1 NC_012468.1 identified by match to protein family HMM PF04914; match to protein family HMM PF04915; match to protein family HMM PF04918; D-alanine transfer from undecaprenol-phosphate to the poly 2117355 7684613 SP70585_2300 Streptococcus pneumoniae 70585 D-alanine transfer from undecaprenol-phosphate to the poly YP_002741456.1 2116087 R 488221 CDS YP_002741457.1 225859947 7683549 complement(2117348..2117587) 1 NC_012468.1 D-alanyl carrier protein subunit; involved in the incorporation of D-alanine into membrane-associated D-alanyl-lipoteichoic acid; D-alanyl carrier protein is the acceptor of activated D-alanine which it donates to a membrane acceptor(D-alanyl transferase) for incorporation into membrane lipoteichoic acid; D-alanine--poly(phosphoribitol) ligase subunit 2 2117587 dltC 7683549 dltC Streptococcus pneumoniae 70585 D-alanine--poly(phosphoribitol) ligase subunit 2 YP_002741457.1 2117348 R 488221 CDS YP_002741458.1 225859948 7684868 complement(2118842..2120392) 1 NC_012468.1 transfers D-alanine to the D-alanyl carrier protein during the incorporation of D-alanine into lipoteichoic acid; D-alanine--poly(phosphoribitol) ligase subunit 1 2120392 dltA 7684868 dltA Streptococcus pneumoniae 70585 D-alanine--poly(phosphoribitol) ligase subunit 1 YP_002741458.1 2118842 R 488221 CDS YP_002741459.1 225859949 7684634 complement(2120413..2120544) 1 NC_012468.1 hypothetical protein 2120544 7684634 SP70585_2305 Streptococcus pneumoniae 70585 hypothetical protein YP_002741459.1 2120413 R 488221 CDS YP_002741460.1 225859950 7683734 complement(2120868..2121773) 1 NC_012468.1 permease of the major facilitator superfamily 2121773 7683734 SP70585_2306 Streptococcus pneumoniae 70585 permease of the major facilitator superfamily YP_002741460.1 2120868 R 488221 CDS YP_002741461.1 225859951 7684295 complement(2122502..2123779) 1 NC_012468.1 identified by match to protein family HMM PF00078; match to protein family HMM PF08388; GBSi1, group II intron, maturase 2123779 7684295 SP70585_2307 Streptococcus pneumoniae 70585 GBSi1, group II intron, maturase YP_002741461.1 2122502 R 488221 CDS YP_002741462.1 225859952 7683112 2124818..2125477 1 NC_012468.1 hypothetical protein 2125477 7683112 SP70585_2308 Streptococcus pneumoniae 70585 hypothetical protein YP_002741462.1 2124818 D 488221 CDS YP_002741463.1 225859953 7684724 complement(2125564..2125767) 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 2125767 7684724 SP70585_2309 Streptococcus pneumoniae 70585 hypothetical protein YP_002741463.1 2125564 R 488221 CDS YP_002741464.1 225859954 7685080 complement(2126064..2126768) 1 NC_012468.1 identified by match to protein family HMM PF00230; match to protein family HMM TIGR00861; glycerol uptake facilitator protein 2126768 7685080 SP70585_2310 Streptococcus pneumoniae 70585 glycerol uptake facilitator protein YP_002741464.1 2126064 R 488221 CDS YP_002741465.1 225859955 7683795 complement(2126838..2128664) 1 NC_012468.1 identified by match to protein family HMM PF01266; alpha-glycerophosphate oxidase (Glycerol-3-phosphateoxidase) (Exported protein 6) 2128664 7683795 SP70585_2311 Streptococcus pneumoniae 70585 alpha-glycerophosphate oxidase (Glycerol-3-phosphateoxidase) (Exported protein 6) YP_002741465.1 2126838 R 488221 CDS YP_002741466.1 225859956 7685057 complement(2128706..2130214) 1 NC_012468.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase 2130214 glpK 7685057 glpK Streptococcus pneumoniae 70585 glycerol kinase YP_002741466.1 2128706 R 488221 CDS YP_002741467.1 225859957 7683385 complement(2130373..2131782) 1 NC_012468.1 identified by match to protein family HMM PF05043; M protein trans-acting positive regulator (MGA) 2131782 7683385 SP70585_2313 Streptococcus pneumoniae 70585 M protein trans-acting positive regulator (MGA) YP_002741467.1 2130373 R 488221 CDS YP_002741468.1 225859958 7683772 2131965..2132837 1 NC_012468.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; Hsp33-like chaperonin 2132837 hslO 7683772 hslO Streptococcus pneumoniae 70585 Hsp33-like chaperonin YP_002741468.1 2131965 D 488221 CDS YP_002741469.1 225859959 7684977 2132824..2133804 1 NC_012468.1 identified by match to protein family HMM PF00724; match to protein family HMM PF01180; match to protein family HMM PF01207; match to protein family HMM TIGR00737; tRNA-dihydrouridine synthase B 2133804 7684977 SP70585_2315 Streptococcus pneumoniae 70585 tRNA-dihydrouridine synthase B YP_002741469.1 2132824 D 488221 CDS YP_002741470.1 225859960 7683177 complement(2134034..2136112) 1 NC_012468.1 identified by match to protein family HMM PF01473; match to protein family HMM PF04650; match to protein family HMM PF05062; match to protein family HMM TIGR01168; choline binding protein A 2136112 7683177 SP70585_2316 Streptococcus pneumoniae 70585 choline binding protein A YP_002741470.1 2134034 R 488221 CDS YP_002741471.1 225859961 7685013 complement(2136191..2136718) 1 NC_012468.1 identified by match to protein family HMM PF04140; hypothetical protein 2136718 7685013 SP70585_2317 Streptococcus pneumoniae 70585 hypothetical protein YP_002741471.1 2136191 R 488221 CDS YP_002741472.1 225859962 7683834 complement(2136801..2138132) 1 NC_012468.1 identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; histidine kinase 2138132 7683834 SP70585_2318 Streptococcus pneumoniae 70585 histidine kinase YP_002741472.1 2136801 R 488221 CDS YP_002741473.1 225859963 7683389 complement(2138129..2138782) 1 NC_012468.1 identified by match to protein family HMM PF00072; match to protein family HMM PF00486; response regulator 2138782 7683389 SP70585_2319 Streptococcus pneumoniae 70585 response regulator YP_002741473.1 2138129 R 488221 CDS YP_002741474.1 225859964 7685064 complement(2139071..2139205) 1 NC_012468.1 hypothetical protein 2139205 7685064 SP70585_2320 Streptococcus pneumoniae 70585 hypothetical protein YP_002741474.1 2139071 R 488221 CDS YP_002741475.1 225859965 7683526 2139222..2139353 1 NC_012468.1 DNA alkylation repair enzyme 2139353 7683526 SP70585_2321 Streptococcus pneumoniae 70585 DNA alkylation repair enzyme YP_002741475.1 2139222 D 488221 CDS YP_002741476.1 225859966 7684479 complement(2139424..2141856) 1 NC_012468.1 identified by match to protein family HMM PF00004; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM PF07728; ClpB protein 2141856 clpB 7684479 clpB Streptococcus pneumoniae 70585 ClpB protein YP_002741476.1 2139424 R 488221 CDS YP_002741477.1 225859967 7684014 complement(2141858..2142316) 1 NC_012468.1 identified by match to protein family HMM PF05848; transcriptional regulator CtsR 2142316 7684014 SP70585_2323 Streptococcus pneumoniae 70585 transcriptional regulator CtsR YP_002741477.1 2141858 R 488221 CDS YP_002741478.1 225859968 7685167 complement(2142435..2143163) 1 NC_012468.1 identified by match to protein family HMM PF00005; anion ABC transporter ATP-binding protein 2143163 7685167 SP70585_2324 Streptococcus pneumoniae 70585 anion ABC transporter ATP-binding protein YP_002741478.1 2142435 R 488221 CDS YP_002741479.1 225859969 7683960 complement(2143163..2144170) 1 NC_012468.1 identified by match to protein family HMM PF09084; ABC transporter substrate-binding protein 2144170 7683960 SP70585_2325 Streptococcus pneumoniae 70585 ABC transporter substrate-binding protein YP_002741479.1 2143163 R 488221 CDS YP_002741480.1 225859970 7684143 complement(2144208..2144969) 1 NC_012468.1 identified by match to protein family HMM PF00528; ABC transporter permease 2144969 7684143 SP70585_2326 Streptococcus pneumoniae 70585 ABC transporter permease YP_002741480.1 2144208 R 488221 CDS YP_002741481.1 225859971 7684871 complement(2144929..2145219) 1 NC_012468.1 hypothetical protein 2145219 7684871 SP70585_2327 Streptococcus pneumoniae 70585 hypothetical protein YP_002741481.1 2144929 R 488221 CDS YP_002741482.1 225859972 7684715 complement(2145475..2146593) 1 NC_012468.1 identified by match to protein family HMM PF01473; match to protein family HMM PF05257; match to protein family HMM PF08460; choline binding protein D 2146593 7684715 SP70585_2328 Streptococcus pneumoniae 70585 choline binding protein D YP_002741482.1 2145475 R 488221 CDS YP_002741483.1 225859973 7684252 complement(2146682..2146948) 1 NC_012468.1 identified by match to protein family HMM PF06257; hypothetical protein 2146948 7684252 SP70585_2329 Streptococcus pneumoniae 70585 hypothetical protein YP_002741483.1 2146682 R 488221 CDS YP_002741484.1 225859974 7684467 complement(2146950..2148302) 1 NC_012468.1 unwinds double stranded DNA; replicative DNA helicase 2148302 dnaB 7684467 dnaB Streptococcus pneumoniae 70585 replicative DNA helicase YP_002741484.1 2146950 R 488221 CDS YP_002741485.1 225859975 7684624 complement(2148345..2148797) 1 NC_012468.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 2148797 rplI 7684624 rplI Streptococcus pneumoniae 70585 50S ribosomal protein L9 YP_002741485.1 2148345 R 488221 CDS YP_002741486.1 225859976 7683996 complement(2148794..2150767) 1 NC_012468.1 identified by match to protein family HMM PF01368; match to protein family HMM PF02272; DHH subfamily 1 protein 2150767 7683996 SP70585_2332 Streptococcus pneumoniae 70585 DHH subfamily 1 protein YP_002741486.1 2148794 R 488221 CDS YP_002741487.1 225859977 7683520 complement(2150903..2151451) 1 NC_012468.1 identified by match to protein family HMM PF02482; match to protein family HMM TIGR00741; ribosome-associated protein Y 2151451 7683520 SP70585_2333 Streptococcus pneumoniae 70585 ribosome-associated protein Y YP_002741487.1 2150903 R 488221 CDS YP_002741488.1 225859978 7684169 complement(2151530..2152192) 1 NC_012468.1 transformation-related protein 2152192 7684169 SP70585_2334 Streptococcus pneumoniae 70585 transformation-related protein YP_002741488.1 2151530 R 488221 CDS YP_002741489.1 225859979 7683042 complement(2152189..2153487) 1 NC_012468.1 identified by match to protein family HMM PF00271; match to protein family HMM PF04851; superfamily II ATP-dependent DNA/RNA helicase required for DNA uptake 2153487 7683042 SP70585_2335 Streptococcus pneumoniae 70585 superfamily II ATP-dependent DNA/RNA helicase required for DNA uptake YP_002741489.1 2152189 R 488221 CDS YP_002741490.1 225859980 7683492 2153543..2154178 1 NC_012468.1 identified by match to protein family HMM PF01205; match to protein family HMM PF09186; match to protein family HMM TIGR00257; hypothetical protein 2154178 7683492 SP70585_2336 Streptococcus pneumoniae 70585 hypothetical protein YP_002741490.1 2153543 D 488221 CDS YP_002741491.1 225859981 7684350 2154463..2155383 1 NC_012468.1 identified by match to protein family HMM PF00291; match to protein family HMM TIGR01136; match to protein family HMM TIGR01139; cysteine synthase A 2155383 cysK 7684350 cysK Streptococcus pneumoniae 70585 cysteine synthase A YP_002741491.1 2154463 D 488221 CDS YP_002741492.1 225859982 7684249 complement(2155580..2155978) 1 NC_012468.1 an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF03050; transposase 2155978 7684249 SP70585_2338 Streptococcus pneumoniae 70585 transposase YP_002741492.1 2155580 R 488221 CDS YP_002741493.1 225859983 7685090 2156011..2156277 1 NC_012468.1 transposase family protein 2156277 7685090 SP70585_2339 Streptococcus pneumoniae 70585 transposase family protein YP_002741493.1 2156011 D 488221 CDS YP_002741494.1 225859984 7684705 complement(2156450..2156737) 1 NC_012468.1 identified by match to protein family HMM PF05717; transposase 2156737 7684705 SP70585_2340 Streptococcus pneumoniae 70585 transposase YP_002741494.1 2156450 R 488221 CDS YP_002741495.1 225859985 7684260 complement(2156983..2158023) 1 NC_012468.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 2158023 tsf 7684260 tsf Streptococcus pneumoniae 70585 elongation factor Ts YP_002741495.1 2156983 R 488221 CDS YP_002741496.1 225859986 7683518 complement(2158102..2158881) 1 NC_012468.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 2158881 rpsB 7683518 rpsB Streptococcus pneumoniae 70585 30S ribosomal protein S2 YP_002741496.1 2158102 R 488221 CDS YP_002741497.1 225859987 7683993 complement(2159105..2160283) 1 NC_012468.1 identified by match to protein family HMM PF05257; general stress protein GSP-781 2160283 7683993 SP70585_2343 Streptococcus pneumoniae 70585 general stress protein GSP-781 YP_002741497.1 2159105 R 488221 CDS YP_002741498.1 225859988 7684148 complement(2160377..2160871) 1 NC_012468.1 identified by match to protein family HMM PF04093; match to protein family HMM TIGR03426; rod shape-determining protein MreD 2160871 mreD 7684148 mreD Streptococcus pneumoniae 70585 rod shape-determining protein MreD YP_002741498.1 2160377 R 488221 CDS YP_002741499.1 225859989 7683865 complement(2160871..2161689) 1 NC_012468.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall; rod shape-determining protein MreC 2161689 mreC 7683865 mreC Streptococcus pneumoniae 70585 rod shape-determining protein MreC YP_002741499.1 2160871 R 488221 CDS YP_002741500.1 225859990 7683951 complement(2161748..2162542) 1 NC_012468.1 identified by match to protein family HMM PF02361; ABC transporter permease 2162542 7683951 SP70585_2346 Streptococcus pneumoniae 70585 ABC transporter permease YP_002741500.1 2161748 R 488221 CDS YP_002741501.1 225859991 7684501 complement(2162535..2163374) 1 NC_012468.1 with CbiNQ forms the ABC transporter for cobalt import; Streptococcus has two adjacent copies of this gene; cobalt transporter ATP-binding subunit 2163374 cbiO 7684501 cbiO Streptococcus pneumoniae 70585 cobalt transporter ATP-binding subunit YP_002741501.1 2162535 R 488221 CDS YP_002741502.1 225859992 7684079 complement(2163359..2164186) 1 NC_012468.1 with CbiNQ forms the ABC transporter for cobalt import; Streptococcus has two adjacent copies of this gene; cobalt transporter ATP-binding subunit 2164186 cbiO 7684079 cbiO Streptococcus pneumoniae 70585 cobalt transporter ATP-binding subunit YP_002741502.1 2163359 R 488221 CDS YP_002741503.1 225859993 7684905 complement(2164183..2164728) 1 NC_012468.1 identified by match to protein family HMM PF01066; match to protein family HMM TIGR00560; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 2164728 pgsA 7684905 pgsA Streptococcus pneumoniae 70585 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase YP_002741503.1 2164183 R 488221 CDS YP_002741504.1 225859994 7683223 complement(2164739..2165560) 1 NC_012468.1 hypothetical protein 2165560 7683223 SP70585_2350 Streptococcus pneumoniae 70585 hypothetical protein YP_002741504.1 2164739 R 488221 CDS YP_002741505.1 225859995 7683423 complement(2165602..2166885) 1 NC_012468.1 identified by match to protein family HMM PF00675; match to protein family HMM PF05193; peptidase, M16 family 2166885 7683423 SP70585_2351 Streptococcus pneumoniae 70585 peptidase, M16 family YP_002741505.1 2165602 R 488221 CDS YP_002741506.1 225859996 7682890 complement(2166882..2168132) 1 NC_012468.1 identified by match to protein family HMM PF05193; peptidase, M16 family 2168132 7682890 SP70585_2352 Streptococcus pneumoniae 70585 peptidase, M16 family YP_002741506.1 2166882 R 488221 CDS YP_002741507.1 225859997 7685049 2168291..2168659 1 NC_012468.1 identified by match to protein family HMM TIGR02988; S4 domain protein YaaA, putative 2168659 7685049 SP70585_2353 Streptococcus pneumoniae 70585 S4 domain protein YaaA, putative YP_002741507.1 2168291 D 488221 CDS YP_002741508.1 225859998 7683798 2168662..2169759 1 NC_012468.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 2169759 recF 7683798 recF Streptococcus pneumoniae 70585 recombination protein F YP_002741508.1 2168662 D 488221 CDS YP_002741509.1 225859999 7683038 complement(2169810..2171288) 1 NC_012468.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase 2171288 guaB 7683038 guaB Streptococcus pneumoniae 70585 inosine 5'-monophosphate dehydrogenase YP_002741509.1 2169810 R 488221 CDS YP_002741510.1 225860000 7684080 complement(2171440..2172465) 1 NC_012468.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase II 2172465 trpS 7684080 trpS Streptococcus pneumoniae 70585 tryptophanyl-tRNA synthetase II YP_002741510.1 2171440 R 488221 CDS YP_002741511.1 225860001 7683879 2172671..2174293 1 NC_012468.1 identified by match to protein family HMM PF00005; ATPase component of ABC transporters with duplicated ATPase domains 2174293 7683879 SP70585_2357 Streptococcus pneumoniae 70585 ATPase component of ABC transporters with duplicated ATPase domains YP_002741511.1 2172671 D 488221 CDS YP_002741512.1 225860002 7683987 2174355..2176907 1 NC_012468.1 ABC transporter permease 2176907 7683987 SP70585_2358 Streptococcus pneumoniae 70585 ABC transporter permease YP_002741512.1 2174355 D 488221 CDS YP_002741513.1 225860003 7684215 complement(2177350..2177688) 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 2177688 7684215 SP70585_2359 Streptococcus pneumoniae 70585 hypothetical protein YP_002741513.1 2177350 R 488221 CDS YP_002741514.1 225860004 7685096 complement(2177773..2178540) 1 NC_012468.1 identified by glimmer; putative; hypothetical protein 2178540 7685096 SP70585_2360 Streptococcus pneumoniae 70585 hypothetical protein YP_002741514.1 2177773 R 488221 CDS YP_002741515.1 225860005 7684258 2178719..2179261 1 NC_012468.1 identified by match to protein family HMM PF00440; TetR family transcriptional regulator 2179261 7684258 SP70585_2361 Streptococcus pneumoniae 70585 TetR family transcriptional regulator YP_002741515.1 2178719 D 488221 CDS YP_002741516.1 225860006 7683927 complement(2179504..2180256) 1 NC_012468.1 identified by match to protein family HMM PF00072; match to protein family HMM PF04397; response regulator 2180256 7683927 SP70585_2364 Streptococcus pneumoniae 70585 response regulator YP_002741516.1 2179504 R 488221 CDS YP_002741517.1 225860007 7684204 complement(2180253..2181578) 1 NC_012468.1 identified by match to protein family HMM PF02518; ComD 2181578 7684204 SP70585_2365 Streptococcus pneumoniae 70585 ComD YP_002741517.1 2180253 R 488221 CDS YP_002741518.1 225860008 7683726 complement(2181599..2181724) 1 NC_012468.1 identified by match to protein family HMM PF03047; hypothetical protein 2181724 7683726 SP70585_2366 Streptococcus pneumoniae 70585 hypothetical protein YP_002741518.1 2181599 R 488221 CDS YP_002741519.1 225860009 7684310 complement(2182007..2182486) 1 NC_012468.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase 2182486 7684310 SP70585_2368 Streptococcus pneumoniae 70585 rRNA large subunit methyltransferase YP_002741519.1 2182007 R 488221 CDS YP_002741520.1 225860010 7683757 2182669..2183850 1 NC_012468.1 identified by match to protein family HMM PF00089; trypsin domain protein 2183850 7683757 SP70585_2369 Streptococcus pneumoniae 70585 trypsin domain protein YP_002741520.1 2182669 D 488221 CDS YP_002741521.1 225860011 7684342 2183908..2184666 1 NC_012468.1 identified by match to protein family HMM PF02195; match to protein family HMM TIGR00180; stage 0 sporulation protein J 2184666 7684342 SP70585_2370 Streptococcus pneumoniae 70585 stage 0 sporulation protein J YP_002741521.1 2183908 D 488221 CDS