-- dump date 20140620_083920 -- class Genbank::Feature -- table feature -- table main -- field 1 id -- field 2 type -- field 3 name -- field 4 contig -- field 5 start_pos -- field 6 end_pos -- field 7 strand -- field 8 description -- field 9 chrom_position -- field 10 organism -- field 11 GeneID -- header -- id type name contig start_pos end_pos strand description chrom_position organism GeneID 488221000001 SEQ_END SEQ_END NC_012468.1 2184682 2184682 DR NC_012468.1; contig end 2184682..2184682 Streptococcus pneumoniae 70585 YP_002739320.1 CDS dnaA NC_012468.1 197 1558 D binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 197..1558 Streptococcus pneumoniae 70585 7683930 YP_002739321.1 CDS dnaN NC_012468.1 1717 2853 D binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 1717..2853 Streptococcus pneumoniae 70585 7684330 YP_002739322.1 CDS SP70585_0003 NC_012468.1 2918 3112 D identified by match to protein family HMM PF06107; hypothetical protein 2918..3112 Streptococcus pneumoniae 70585 7683974 YP_002739323.1 CDS ychF NC_012468.1 3196 4311 D translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 3196..4311 Streptococcus pneumoniae 70585 7684147 YP_002739324.1 CDS pth NC_012468.1 4382 4951 D Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 4382..4951 Streptococcus pneumoniae 70585 7683332 YP_002739325.1 CDS mfd NC_012468.1 4952 8461 D identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM PF02559; match to protein family HMM PF03461; match to protein family HMM PF04851; match to protein family HMM TIGR00580; transcription-repair coupling factor 4952..8461 Streptococcus pneumoniae 70585 7684228 YP_002739326.1 CDS SP70585_0007 NC_012468.1 8519 8785 D identified by match to protein family HMM PF01479; ribosome-associated heat shock protein implicated in the recycling of the 50S subunit 8519..8785 Streptococcus pneumoniae 70585 7683441 YP_002739327.1 CDS SP70585_0008 NC_012468.1 8778 9146 D identified by match to protein family HMM PF04977; septum formation initiator 8778..9146 Streptococcus pneumoniae 70585 7683651 YP_002739328.1 CDS SP70585_0009 NC_012468.1 9151 9273 D hypothetical protein 9151..9273 Streptococcus pneumoniae 70585 7684830 YP_002739329.1 CDS SP70585_0010 NC_012468.1 9266 10534 D beta-lactamase class A 9266..10534 Streptococcus pneumoniae 70585 7683109 YP_002739330.1 CDS SP70585_0011 NC_012468.1 10531 11808 D identified by match to protein family HMM PF01171; match to protein family HMM TIGR02432; match to protein family HMM TIGR02433; tRNA(Ile)-lysidine synthase (tRNA(Ile)-lysidinesynthetase) (tRNA(Ile)-2-lysyl-cytidine synthase) 10531..11808 Streptococcus pneumoniae 70585 7684646 YP_002739331.1 CDS hpt NC_012468.1 11812 12354 D identified by match to protein family HMM PF00156; match to protein family HMM TIGR01203; hypoxanthine phosphoribosyltransferase 11812..12354 Streptococcus pneumoniae 70585 7684919 YP_002739332.1 CDS hflB NC_012468.1 12370 14328 D identified by match to protein family HMM PF00004; match to protein family HMM PF01434; match to protein family HMM PF06480; match to protein family HMM TIGR01241; ATP-dependent metallopeptidase HflB 12370..14328 Streptococcus pneumoniae 70585 7682999 YP_002739333.1 CDS SP70585_0014 NC_012468.1 14392 15648 R identified by match to protein family HMM PF01610; transposase complement(14392..15648) Streptococcus pneumoniae 70585 7683672 YP_002739334.1 CDS SP70585_0015 NC_012468.1 15872 16351 D competence-specific global transcription modulator 15872..16351 Streptococcus pneumoniae 70585 7684454 YP_002739335.1 CDS SP70585_0023 NC_012468.1 21928 22110 D transposase 21928..22110 Streptococcus pneumoniae 70585 7683905 YP_002739336.1 CDS SP70585_0024 NC_012468.1 22187 22330 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase complement(22187..22330) Streptococcus pneumoniae 70585 7683514 YP_002739337.1 CDS SP70585_0025 NC_012468.1 22378 22584 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase complement(22378..22584) Streptococcus pneumoniae 70585 7683085 YP_002739338.1 CDS SP70585_0026 NC_012468.1 22901 23137 D hypothetical protein 22901..23137 Streptococcus pneumoniae 70585 7684649 YP_002739339.1 CDS purA NC_012468.1 23326 24654 D catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 23326..24654 Streptococcus pneumoniae 70585 7684942 YP_002739340.1 CDS SP70585_0028 NC_012468.1 24896 26044 R identified by match to protein family HMM PF00589; integrase complement(24896..26044) Streptococcus pneumoniae 70585 7684051 YP_002739341.1 CDS SP70585_0029 NC_012468.1 26216 27130 R identified by match to protein family HMM PF08797; phage protein complement(26216..27130) Streptococcus pneumoniae 70585 7684638 YP_002739342.1 CDS SP70585_0030 NC_012468.1 27142 27525 R identified by match to protein family HMM PF06114; hypothetical protein complement(27142..27525) Streptococcus pneumoniae 70585 7683119 YP_002739343.1 CDS SP70585_0031 NC_012468.1 27538 27903 R identified by match to protein family HMM PF01381; phage transcriptional regulator, Cro/CI family complement(27538..27903) Streptococcus pneumoniae 70585 7683273 YP_002739344.1 CDS SP70585_0032 NC_012468.1 28189 28335 D hypothetical protein 28189..28335 Streptococcus pneumoniae 70585 7684762 YP_002739345.1 CDS SP70585_0033 NC_012468.1 28328 28531 D hypothetical protein 28328..28531 Streptococcus pneumoniae 70585 7683301 YP_002739346.1 CDS SP70585_0034 NC_012468.1 28543 28677 D hypothetical protein 28543..28677 Streptococcus pneumoniae 70585 7684111 YP_002739347.1 CDS SP70585_0035 NC_012468.1 28674 29387 D identified by match to protein family HMM PF02498; gp15 28674..29387 Streptococcus pneumoniae 70585 7685026 YP_002739348.1 CDS SP70585_0036 NC_012468.1 29399 29656 D phage protein 29399..29656 Streptococcus pneumoniae 70585 7684835 YP_002739349.1 CDS SP70585_0037 NC_012468.1 29742 30062 D hypothetical protein 29742..30062 Streptococcus pneumoniae 70585 7683095 YP_002739350.1 CDS SP70585_0038 NC_012468.1 30078 30377 D gp18 30078..30377 Streptococcus pneumoniae 70585 7683248 YP_002739351.1 CDS SP70585_0039 NC_012468.1 30368 31156 D identified by match to protein family HMM PF04271; match to protein family HMM TIGR01446; match to protein family HMM TIGR01714; putative phage-associated protein 30368..31156 Streptococcus pneumoniae 70585 7683735 YP_002739352.1 CDS SP70585_0040 NC_012468.1 31144 31302 D hypothetical protein 31144..31302 Streptococcus pneumoniae 70585 7682980 YP_002739353.1 CDS SP70585_0041 NC_012468.1 31296 32066 D gp21 31296..32066 Streptococcus pneumoniae 70585 7683791 YP_002739354.1 CDS SP70585_0042 NC_012468.1 32081 32275 D identified by glimmer; putative; hypothetical protein 32081..32275 Streptococcus pneumoniae 70585 7685077 YP_002739355.1 CDS SP70585_0043 NC_012468.1 32275 32502 D hypothetical protein 32275..32502 Streptococcus pneumoniae 70585 7683432 YP_002739356.1 CDS SP70585_0044 NC_012468.1 32629 32793 D identified by glimmer; putative; hypothetical protein 32629..32793 Streptococcus pneumoniae 70585 7683764 YP_002739357.1 CDS SP70585_0045 NC_012468.1 32964 33281 D gp24 32964..33281 Streptococcus pneumoniae 70585 7684790 YP_002739358.1 CDS SP70585_0046 NC_012468.1 33283 33792 D identified by match to protein family HMM PF07852; hypothetical protein 33283..33792 Streptococcus pneumoniae 70585 7683686 YP_002739359.1 CDS SP70585_0047 NC_012468.1 33785 34375 D identified by similarity to GB:AAZ82434.1; match to protein family HMM PF07852; hypothetical protein 33785..34375 Streptococcus pneumoniae 70585 7683388 YP_002739360.1 CDS SP70585_0048 NC_012468.1 34375 34536 D identified by glimmer; putative; hypothetical protein 34375..34536 Streptococcus pneumoniae 70585 7685159 YP_002739361.1 CDS SP70585_0049 NC_012468.1 34533 34667 D gp27 34533..34667 Streptococcus pneumoniae 70585 7684961 YP_002739362.1 CDS SP70585_0050 NC_012468.1 34725 35069 D identified by match to protein family HMM TIGR01671; hypothetical protein 34725..35069 Streptococcus pneumoniae 70585 7683562 YP_002739363.1 CDS SP70585_0051 NC_012468.1 35069 35305 D gp29 35069..35305 Streptococcus pneumoniae 70585 7685162 YP_002739364.1 CDS SP70585_0052 NC_012468.1 35467 35697 D identified by match to protein family HMM PF01381; prophage LambdaBa04, DNA-binding protein 35467..35697 Streptococcus pneumoniae 70585 7685089 YP_002739365.1 CDS SP70585_0053 NC_012468.1 35770 36198 D identified by match to protein family HMM TIGR01637; gp31 35770..36198 Streptococcus pneumoniae 70585 7684212 YP_002739366.1 CDS SP70585_0054 NC_012468.1 36488 37054 D identified by match to protein family HMM PF00589; site-specific recombinase, phage integrase family protein 36488..37054 Streptococcus pneumoniae 70585 7684382 YP_002739367.1 CDS SP70585_0055 NC_012468.1 37069 37200 R identified by glimmer; putative; hypothetical protein complement(37069..37200) Streptococcus pneumoniae 70585 7685084 YP_002739368.1 CDS SP70585_0056 NC_012468.1 37288 37632 D identified by match to protein family HMM PF01844; HNH endonuclease domain protein 37288..37632 Streptococcus pneumoniae 70585 7684806 YP_002739369.1 CDS SP70585_0057 NC_012468.1 37771 39075 D identified by match to protein family HMM PF07360; hypothetical protein 37771..39075 Streptococcus pneumoniae 70585 7683443 YP_002739370.1 CDS SP70585_0058 NC_012468.1 39029 40420 D gp35 39029..40420 Streptococcus pneumoniae 70585 7683206 YP_002739371.1 CDS SP70585_0059 NC_012468.1 40410 40649 D identified by glimmer; putative; hypothetical protein 40410..40649 Streptococcus pneumoniae 70585 7684118 YP_002739372.1 CDS SP70585_0060 NC_012468.1 40702 40932 D identified by glimmer; putative; hypothetical protein 40702..40932 Streptococcus pneumoniae 70585 7685152 YP_002739373.1 CDS SP70585_0061 NC_012468.1 40983 42395 D identified by match to protein family HMM PF03354; putative phage terminase, large subunit 40983..42395 Streptococcus pneumoniae 70585 7684337 YP_002739374.1 CDS SP70585_0062 NC_012468.1 42477 42941 D phage protein 42477..42941 Streptococcus pneumoniae 70585 7684600 YP_002739375.1 CDS SP70585_0063 NC_012468.1 42947 43846 D major head protein 42947..43846 Streptococcus pneumoniae 70585 7684107 YP_002739376.1 CDS SP70585_0064 NC_012468.1 43852 44064 D hypothetical protein 43852..44064 Streptococcus pneumoniae 70585 7683367 YP_002739377.1 CDS SP70585_0065 NC_012468.1 44068 44508 D hypothetical protein 44068..44508 Streptococcus pneumoniae 70585 7683706 YP_002739378.1 CDS SP70585_0066 NC_012468.1 44486 44791 D hypothetical protein 44486..44791 Streptococcus pneumoniae 70585 7682966 YP_002739379.1 CDS SP70585_0067 NC_012468.1 44793 45020 D hypothetical protein 44793..45020 Streptococcus pneumoniae 70585 7684550 YP_002739380.1 CDS SP70585_0068 NC_012468.1 45017 45352 D gp45 45017..45352 Streptococcus pneumoniae 70585 7684811 YP_002739381.1 CDS SP70585_0069 NC_012468.1 45368 45976 D major tail protein 45368..45976 Streptococcus pneumoniae 70585 7684272 YP_002739382.1 CDS SP70585_0070 NC_012468.1 45982 46257 D phage protein 45982..46257 Streptococcus pneumoniae 70585 7683439 YP_002739383.1 CDS SP70585_0071 NC_012468.1 46269 46655 D hypothetical protein 46269..46655 Streptococcus pneumoniae 70585 7683890 YP_002739384.1 CDS SP70585_0072 NC_012468.1 46655 49120 D identified by match to protein family HMM PF05017; PblA 46655..49120 Streptococcus pneumoniae 70585 7683049 YP_002739385.1 CDS SP70585_0073 NC_012468.1 49120 49818 D hypothetical protein 49120..49818 Streptococcus pneumoniae 70585 7683482 YP_002739386.1 CDS SP70585_0074 NC_012468.1 49815 58727 D identified by match to protein family HMM PF02018; match to protein family HMM TIGR01665; PblB 49815..58727 Streptococcus pneumoniae 70585 7683831 YP_002739387.1 CDS SP70585_0075 NC_012468.1 58822 59025 D hypothetical protein 58822..59025 Streptococcus pneumoniae 70585 7684254 YP_002739388.1 CDS SP70585_0076 NC_012468.1 59028 59378 D hypothetical protein 59028..59378 Streptococcus pneumoniae 70585 7682939 YP_002739389.1 CDS SP70585_0077 NC_012468.1 59387 59803 D identified by match to protein family HMM PF05105; match to protein family HMM TIGR01593; putative holin 1 59387..59803 Streptococcus pneumoniae 70585 7684136 YP_002739390.1 CDS SP70585_0078 NC_012468.1 59807 60142 D identified by match to protein family HMM TIGR01673; phage holin, LL-H family 59807..60142 Streptococcus pneumoniae 70585 7684632 YP_002739391.1 CDS SP70585_0079 NC_012468.1 60142 61098 D identified by match to protein family HMM PF01473; match to protein family HMM PF01510; lytic amidase (N-acetylmuramoyl-L-alanine amidase) 60142..61098 Streptococcus pneumoniae 70585 7684018 YP_002739392.1 CDS SP70585_0080 NC_012468.1 61236 61415 R hypothetical protein complement(61236..61415) Streptococcus pneumoniae 70585 7683276 YP_002739393.1 CDS SP70585_0081 NC_012468.1 61967 62434 D identified by match to protein family HMM PF00383; tRNA-specific adenosine deaminase 61967..62434 Streptococcus pneumoniae 70585 7683081 YP_002739394.1 CDS dut NC_012468.1 62620 63063 D catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 62620..63063 Streptococcus pneumoniae 70585 7684280 YP_002739395.1 CDS SP70585_0083 NC_012468.1 63023 63580 D identified by match to protein family HMM PF00300; phosphoglycerate mutase family protein 63023..63580 Streptococcus pneumoniae 70585 7683737 YP_002739396.1 CDS radA NC_012468.1 63693 64955 D Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 63693..64955 Streptococcus pneumoniae 70585 7683405 YP_002739397.1 CDS SP70585_0085 NC_012468.1 65028 65525 D identified by match to protein family HMM PF00484; carbonate dehydratase 65028..65525 Streptococcus pneumoniae 70585 7684513 YP_002739398.1 CDS SP70585_0086 NC_012468.1 65550 66365 D hypothetical protein 65550..66365 Streptococcus pneumoniae 70585 7684877 YP_002739399.1 CDS SP70585_0087 NC_012468.1 66510 67478 D catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 66510..67478 Streptococcus pneumoniae 70585 7684736 YP_002739400.1 CDS SP70585_0088 NC_012468.1 67600 67893 R transposase complement(67600..67893) Streptococcus pneumoniae 70585 7683606 YP_002739401.1 CDS SP70585_0089 NC_012468.1 68020 68253 R hypothetical protein complement(68020..68253) Streptococcus pneumoniae 70585 7684088 YP_002739402.1 CDS SP70585_0090 NC_012468.1 68246 68362 R hypothetical protein complement(68246..68362) Streptococcus pneumoniae 70585 7683348 YP_002739403.1 CDS SP70585_0091 NC_012468.1 68577 68891 R hypothetical protein complement(68577..68891) Streptococcus pneumoniae 70585 7683542 YP_002739404.1 CDS SP70585_0092 NC_012468.1 69183 71816 D has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 69183..71816 Streptococcus pneumoniae 70585 7683610 YP_002739405.1 CDS SP70585_0093 NC_012468.1 71901 72338 D identified by match to protein family HMM PF02629; CoA binding protein 71901..72338 Streptococcus pneumoniae 70585 7684500 YP_002739406.1 CDS SP70585_0094 NC_012468.1 72576 73586 R identified by match to protein family HMM PF03601; membrane protein Spr0034 complement(72576..73586) Streptococcus pneumoniae 70585 7684893 YP_002739407.1 CDS SP70585_0095 NC_012468.1 73735 74904 D catalyzes the transamination of the aromatic amino acid forming a ketoacid; first step in aromatic amino acid degradation in lactococci; aromatic amino acid aminotransferase 73735..74904 Streptococcus pneumoniae 70585 7683962 YP_002739408.1 CDS recO NC_012468.1 74901 75671 D involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO 74901..75671 Streptococcus pneumoniae 70585 7682947 YP_002739409.1 CDS plsX NC_012468.1 75668 76660 D involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; putative glycerol-3-phosphate acyltransferase PlsX 75668..76660 Streptococcus pneumoniae 70585 7683216 YP_002739410.1 CDS SP70585_0098 NC_012468.1 76666 76899 D hypothetical protein 76666..76899 Streptococcus pneumoniae 70585 7683126 YP_002739411.1 CDS SP70585_0099 NC_012468.1 76942 77235 D mobile genetic element 76942..77235 Streptococcus pneumoniae 70585 7683866 YP_002739412.1 CDS SP70585_0100 NC_012468.1 77438 77668 D identified by match to protein family HMM TIGR01847; hypothetical protein 77438..77668 Streptococcus pneumoniae 70585 7683344 YP_002739413.1 CDS SP70585_0101 NC_012468.1 77671 77796 D hypothetical protein 77671..77796 Streptococcus pneumoniae 70585 7683201 YP_002739414.1 CDS SP70585_0102 NC_012468.1 78094 78207 D identified by glimmer; putative; hypothetical protein 78094..78207 Streptococcus pneumoniae 70585 7683659 YP_002739415.1 CDS SP70585_0103 NC_012468.1 78419 79312 D identified by match to protein family HMM PF01381; XRE family transcriptional regulator 78419..79312 Streptococcus pneumoniae 70585 7683001 YP_002739416.1 CDS SP70585_0104 NC_012468.1 79855 80151 D hypothetical protein 79855..80151 Streptococcus pneumoniae 70585 7684269 YP_002739417.1 CDS SP70585_0105 NC_012468.1 80158 81294 D hypothetical protein 80158..81294 Streptococcus pneumoniae 70585 7684375 YP_002739418.1 CDS SP70585_0106 NC_012468.1 81531 81773 D identified by glimmer; putative; hypothetical protein 81531..81773 Streptococcus pneumoniae 70585 7684954 YP_002739419.1 CDS SP70585_0107 NC_012468.1 81770 82366 D identified by glimmer; putative; hypothetical protein 81770..82366 Streptococcus pneumoniae 70585 7685099 YP_002739420.1 CDS SP70585_0108 NC_012468.1 82347 82838 D identified by glimmer; putative; hypothetical protein 82347..82838 Streptococcus pneumoniae 70585 7683421 YP_002739421.1 CDS SP70585_0109 NC_012468.1 83218 85371 D identified by match to protein family HMM PF00005; match to protein family HMM PF00664; match to protein family HMM PF03412; match to protein family HMM TIGR01193; transport/processing ATP-binding protein ComA 83218..85371 Streptococcus pneumoniae 70585 7684886 YP_002739422.1 CDS SP70585_0110 NC_012468.1 85384 86733 D identified by match to protein family HMM TIGR01000; transport protein ComB 85384..86733 Streptococcus pneumoniae 70585 7684988 YP_002739423.1 CDS purC NC_012468.1 86904 87611 D catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase 86904..87611 Streptococcus pneumoniae 70585 7683756 YP_002739424.1 CDS SP70585_0112 NC_012468.1 87813 91538 D identified by match to protein family HMM PF02769; match to protein family HMM TIGR01857; phosphoribosylformylglycinamidine synthase 87813..91538 Streptococcus pneumoniae 70585 7683464 YP_002739425.1 CDS purF NC_012468.1 91631 93073 D Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 91631..93073 Streptococcus pneumoniae 70585 7683724 YP_002739426.1 CDS purM NC_012468.1 93110 94132 D catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 93110..94132 Streptococcus pneumoniae 70585 7683240 YP_002739427.1 CDS purN NC_012468.1 94129 94674 D glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 94129..94674 Streptococcus pneumoniae 70585 7684195 YP_002739428.1 CDS SP70585_0116 NC_012468.1 94758 95267 D identified by match to protein family HMM PF04892; teicoplanin resistance protein 94758..95267 Streptococcus pneumoniae 70585 7683979 YP_002739429.1 CDS purH NC_012468.1 95292 96839 D involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 95292..96839 Streptococcus pneumoniae 70585 7683040 YP_002739430.1 CDS purD NC_012468.1 96961 98223 D catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 96961..98223 Streptococcus pneumoniae 70585 7684001 YP_002739431.1 CDS SP70585_0119 NC_012468.1 98480 98596 D hypothetical protein 98480..98596 Streptococcus pneumoniae 70585 7684769 YP_002739432.1 CDS purE NC_012468.1 98626 99114 D identified by match to protein family HMM PF00731; match to protein family HMM TIGR01162; phosphoribosylaminoimidazole carboxylase, catalytic subunit 98626..99114 Streptococcus pneumoniae 70585 7683330 YP_002739433.1 CDS purK NC_012468.1 99101 100192 D With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 99101..100192 Streptococcus pneumoniae 70585 7683566 YP_002739434.1 CDS SP70585_0122 NC_012468.1 100202 100429 D hypothetical protein 100202..100429 Streptococcus pneumoniae 70585 7684617 YP_002739435.1 CDS purB NC_012468.1 100492 101790 D Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 100492..101790 Streptococcus pneumoniae 70585 7683318 YP_002739436.1 CDS SP70585_0124 NC_012468.1 101845 105807 R identified by match to protein family HMM PF00728; match to protein family HMM PF00746; match to protein family HMM PF04650; match to protein family HMM PF07501; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; beta-N-acetylhexosaminidase complement(101845..105807) Streptococcus pneumoniae 70585 7684222 YP_002739437.1 CDS SP70585_0125 NC_012468.1 106122 106865 R identified by match to protein family HMM PF00392; match to protein family HMM PF07702; GntR family transcriptional regulator complement(106122..106865) Streptococcus pneumoniae 70585 7683404 YP_002739438.1 CDS SP70585_0126 NC_012468.1 107186 108973 D identified by match to protein family HMM PF01301; match to protein family HMM PF02449; beta-galactosidase 107186..108973 Streptococcus pneumoniae 70585 7683617 YP_002739439.1 CDS SP70585_0127 NC_012468.1 108970 109446 D identified by match to protein family HMM PF03830; phosphotransferase system sugar-specific eiib component 108970..109446 Streptococcus pneumoniae 70585 7684781 YP_002739440.1 CDS SP70585_0128 NC_012468.1 109474 110379 D identified by match to protein family HMM PF03609; PTS system, IIC component 109474..110379 Streptococcus pneumoniae 70585 7684016 YP_002739441.1 CDS SP70585_0129 NC_012468.1 110366 111181 D identified by match to protein family HMM PF03613; PTS system, IID component 110366..111181 Streptococcus pneumoniae 70585 7684519 YP_002739442.1 CDS SP70585_0130 NC_012468.1 111188 111592 D identified by match to protein family HMM PF03610; phosphotransferase system sugar-specific EII component 111188..111592 Streptococcus pneumoniae 70585 7684372 YP_002739443.1 CDS SP70585_0131 NC_012468.1 111845 113011 D identified by match to protein family HMM PF01380; putative tagatose-6-phosphate ketose/aldose isomerase 111845..113011 Streptococcus pneumoniae 70585 7683233 YP_002739444.1 CDS SP70585_0132 NC_012468.1 113127 114164 D identified by match to protein family HMM PF01263; aldose 1-epimerase 113127..114164 Streptococcus pneumoniae 70585 7683722 YP_002739445.1 CDS SP70585_0133 NC_012468.1 114371 115225 D identified by match to protein family HMM PF00903; glyoxalase family protein 114371..115225 Streptococcus pneumoniae 70585 7684162 YP_002739446.1 CDS SP70585_0134 NC_012468.1 115457 115594 D identified by glimmer; putative; hypothetical protein 115457..115594 Streptococcus pneumoniae 70585 7683061 YP_002739447.1 CDS SP70585_0135 NC_012468.1 115724 116110 R chlorohydrolase complement(115724..116110) Streptococcus pneumoniae 70585 7683515 YP_002739448.1 CDS SP70585_0136 NC_012468.1 116331 116447 R identified by glimmer; putative; hypothetical protein complement(116331..116447) Streptococcus pneumoniae 70585 7683788 YP_002739449.1 CDS SP70585_0137 NC_012468.1 116437 116556 R coenzyme A disulfide reductase complement(116437..116556) Streptococcus pneumoniae 70585 7683231 YP_002739450.1 CDS SP70585_0138 NC_012468.1 116668 117432 D identified by match to protein family HMM PF01048; phosphorylase, Pnp/Udp family 116668..117432 Streptococcus pneumoniae 70585 7683663 YP_002739451.1 CDS SP70585_0139 NC_012468.1 117688 117828 D hypothetical protein 117688..117828 Streptococcus pneumoniae 70585 7685016 YP_002739452.1 CDS SP70585_0140 NC_012468.1 117997 119376 D identified by match to protein family HMM PF02386; Trk transporter membrane-spanning protein - K+ transport 117997..119376 Streptococcus pneumoniae 70585 7684922 YP_002739453.1 CDS SP70585_0141 NC_012468.1 119390 120055 D identified by match to protein family HMM PF02254; potassium uptake protein, Trk family 119390..120055 Streptococcus pneumoniae 70585 7684914 YP_002739454.1 CDS SP70585_0142 NC_012468.1 120190 120348 D identified by glimmer; putative; hypothetical protein 120190..120348 Streptococcus pneumoniae 70585 7684376 YP_002739455.1 CDS SP70585_0143 NC_012468.1 120410 120949 D identified by match to protein family HMM PF00535; cell wall biogenesis glycosyltransferase 120410..120949 Streptococcus pneumoniae 70585 7684564 YP_002739456.1 CDS SP70585_0144 NC_012468.1 121016 121426 D cell wall biogenesis glycosyltransferase 121016..121426 Streptococcus pneumoniae 70585 7683845 YP_002739457.1 CDS SP70585_0145 NC_012468.1 121542 125027 D identified by match to protein family HMM PF00746; match to protein family HMM PF04650; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; cell wall surface anchor family protein 121542..125027 Streptococcus pneumoniae 70585 7684757 YP_002739458.1 CDS SP70585_0146 NC_012468.1 125194 125892 D identified by match to protein family HMM PF00072; match to protein family HMM PF00486; response regulator SaeR 125194..125892 Streptococcus pneumoniae 70585 7683326 YP_002739459.1 CDS SP70585_0147 NC_012468.1 125889 126941 D identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; histidine kinase 125889..126941 Streptococcus pneumoniae 70585 7683943 YP_002739460.1 CDS rpsD NC_012468.1 127136 127747 D primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 127136..127747 Streptococcus pneumoniae 70585 7684864 YP_002739461.1 CDS SP70585_0149 NC_012468.1 127932 128090 D an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase 127932..128090 Streptococcus pneumoniae 70585 7684503 YP_002739462.1 CDS SP70585_0150 NC_012468.1 128495 128716 D hypothetical protein 128495..128716 Streptococcus pneumoniae 70585 7683533 YP_002739463.1 CDS SP70585_0151 NC_012468.1 129035 129964 D identified by match to protein family HMM PF00528; ABC transporter permease 129035..129964 Streptococcus pneumoniae 70585 7683806 YP_002739464.1 CDS SP70585_0152 NC_012468.1 129978 130901 D identified by match to protein family HMM PF00528; protein LplC 129978..130901 Streptococcus pneumoniae 70585 7684050 YP_002739465.1 CDS SP70585_0153 NC_012468.1 131111 132586 D identified by match to protein family HMM PF01547; ABC transporter substrate-binding protein 131111..132586 Streptococcus pneumoniae 70585 7683401 YP_002739466.1 CDS SP70585_0154 NC_012468.1 132858 133844 D identified by match to protein family HMM PF00581; hypothetical protein 132858..133844 Streptococcus pneumoniae 70585 7683455 YP_002739467.1 CDS SP70585_0155 NC_012468.1 133966 134826 D hypothetical protein 133966..134826 Streptococcus pneumoniae 70585 7684972 YP_002739468.1 CDS SP70585_0156 NC_012468.1 135004 136068 R hypothetical protein complement(135004..136068) Streptococcus pneumoniae 70585 7682906 YP_002739469.1 CDS SP70585_0157 NC_012468.1 136131 137042 R hypothetical protein complement(136131..137042) Streptococcus pneumoniae 70585 7684020 YP_002739470.1 CDS SP70585_0158 NC_012468.1 137035 137628 R hypothetical protein complement(137035..137628) Streptococcus pneumoniae 70585 7684582 YP_002739471.1 CDS SP70585_0159 NC_012468.1 137615 137941 R identified by match to protein family HMM PF03551; transcription regulator complement(137615..137941) Streptococcus pneumoniae 70585 7685051 YP_002739472.1 CDS SP70585_0160 NC_012468.1 138080 139246 R identified by match to protein family HMM PF07690; cyanate permease complement(138080..139246) Streptococcus pneumoniae 70585 7684484 YP_002739473.1 CDS SP70585_0161 NC_012468.1 139304 139531 D hypothetical protein 139304..139531 Streptococcus pneumoniae 70585 7684974 YP_002739474.1 CDS SP70585_0162 NC_012468.1 139601 139828 D hypothetical protein 139601..139828 Streptococcus pneumoniae 70585 7684590 YP_002739475.1 CDS SP70585_0163 NC_012468.1 139898 140125 D hypothetical protein 139898..140125 Streptococcus pneumoniae 70585 7683025 YP_002739476.1 CDS SP70585_0164 NC_012468.1 140292 141122 D identified by match to protein family HMM PF00535; amylovoran biosynthesis glycosyltransferase AmsE 140292..141122 Streptococcus pneumoniae 70585 7683159 YP_002739477.1 CDS SP70585_0166 NC_012468.1 141208 143058 D identified by match to protein family HMM PF00106; match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF04321; match to protein family HMM PF07993; CapD protein, required for the biosynthesis of type 1 capsular polysaccharide 141208..143058 Streptococcus pneumoniae 70585 7683792 YP_002739478.1 CDS SP70585_0165 NC_012468.1 143037 143312 R chlorohydrolase complement(143037..143312) Streptococcus pneumoniae 70585 7684421 YP_002739479.1 CDS SP70585_0167 NC_012468.1 143362 143994 R identified by match to protein family HMM PF00702; phosphoglycolate phosphatase complement(143362..143994) Streptococcus pneumoniae 70585 7682983 YP_002739480.1 CDS sdaAA NC_012468.1 144016 144888 R identified by match to protein family HMM PF03313; match to protein family HMM TIGR00718; L-serine dehydratase, iron-sulfur-dependent, alpha subunit complement(144016..144888) Streptococcus pneumoniae 70585 7683394 YP_002739481.1 CDS sdaAB NC_012468.1 144897 145568 R identified by match to protein family HMM PF01842; match to protein family HMM PF03315; match to protein family HMM TIGR00719; L-serine dehydratase, iron-sulfur-dependent, beta subunit complement(144897..145568) Streptococcus pneumoniae 70585 7685151 YP_002739482.1 CDS SP70585_0170 NC_012468.1 145810 146397 D identified by match to protein family HMM PF01476; LysM domain protein 145810..146397 Streptococcus pneumoniae 70585 7684993 YP_002739483.1 CDS SP70585_0171 NC_012468.1 146449 146769 R hypothetical protein complement(146449..146769) Streptococcus pneumoniae 70585 7683011 YP_002739484.1 CDS SP70585_0172 NC_012468.1 147195 147482 D identified by match to protein family HMM TIGR01653; bacteriocin, putative 147195..147482 Streptococcus pneumoniae 70585 7683670 YP_002739485.1 CDS SP70585_0173 NC_012468.1 147534 149642 D identified by match to protein family HMM TIGR01654; amino acid ABC transporter permease 147534..149642 Streptococcus pneumoniae 70585 7683679 YP_002739486.1 CDS SP70585_0174 NC_012468.1 149639 150280 D identified by match to protein family HMM PF00005; macrolide export ATP-binding/permease MacB 149639..150280 Streptococcus pneumoniae 70585 7683370 YP_002739487.1 CDS SP70585_0175 NC_012468.1 150487 151293 D identified by match to protein family HMM PF00497; amino acid ABC transporter substrate-binding protein 150487..151293 Streptococcus pneumoniae 70585 7684603 YP_002739488.1 CDS argH NC_012468.1 152536 153927 D catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 152536..153927 Streptococcus pneumoniae 70585 7684924 YP_002739489.1 CDS SP70585_0179 NC_012468.1 154216 155079 R identified by match to protein family HMM PF01381; helix-turn-helix domain protein complement(154216..155079) Streptococcus pneumoniae 70585 7684771 YP_002739490.1 CDS SP70585_0180 NC_012468.1 155533 157764 D identified by match to protein family HMM PF00005; match to protein family HMM PF00664; match to protein family HMM PF03412; match to protein family HMM TIGR01193; transport/processing ATP-binding protein ComA 155533..157764 Streptococcus pneumoniae 70585 7683531 YP_002739491.1 CDS SP70585_0181 NC_012468.1 157757 158224 D hypothetical protein 157757..158224 Streptococcus pneumoniae 70585 7683186 YP_002739492.1 CDS SP70585_0182 NC_012468.1 158221 159573 D hypothetical protein 158221..159573 Streptococcus pneumoniae 70585 7685093 YP_002739493.1 CDS SP70585_0183 NC_012468.1 159719 160099 D hypothetical protein 159719..160099 Streptococcus pneumoniae 70585 7685171 YP_002739494.1 CDS SP70585_0184 NC_012468.1 160602 160922 R hypothetical protein complement(160602..160922) Streptococcus pneumoniae 70585 7684965 YP_002739495.1 CDS SP70585_0185 NC_012468.1 161680 162051 D hypothetical protein 161680..162051 Streptococcus pneumoniae 70585 7684596 YP_002739496.1 CDS SP70585_0186 NC_012468.1 162059 162271 D hypothetical protein 162059..162271 Streptococcus pneumoniae 70585 7683430 YP_002739497.1 CDS SP70585_0187 NC_012468.1 162645 162770 D hypothetical protein 162645..162770 Streptococcus pneumoniae 70585 7685041 YP_002739498.1 CDS SP70585_0188 NC_012468.1 162751 162996 D identified by glimmer; putative; hypothetical protein 162751..162996 Streptococcus pneumoniae 70585 7684728 YP_002739499.1 CDS SP70585_0189 NC_012468.1 163153 164211 D hypothetical protein 163153..164211 Streptococcus pneumoniae 70585 7683342 YP_002739500.1 CDS SP70585_0190 NC_012468.1 164526 165503 D hypothetical protein 164526..165503 Streptococcus pneumoniae 70585 7684967 YP_002739501.1 CDS SP70585_0191 NC_012468.1 165880 166254 D hypothetical protein 165880..166254 Streptococcus pneumoniae 70585 7683000 YP_002739502.1 CDS SP70585_0192 NC_012468.1 166261 166443 D hypothetical protein 166261..166443 Streptococcus pneumoniae 70585 7683548 YP_002739503.1 CDS SP70585_0193 NC_012468.1 166462 167364 D hypothetical protein 166462..167364 Streptococcus pneumoniae 70585 7683635 YP_002739504.1 CDS SP70585_0194 NC_012468.1 167420 167773 D hypothetical protein 167420..167773 Streptococcus pneumoniae 70585 7684856 YP_002739505.1 CDS SP70585_0195 NC_012468.1 167770 168498 D hypothetical protein 167770..168498 Streptococcus pneumoniae 70585 7683882 YP_002739506.1 CDS SP70585_0196 NC_012468.1 169625 170128 D identified by glimmer; putative; hypothetical protein 169625..170128 Streptococcus pneumoniae 70585 7683934 YP_002739507.1 CDS SP70585_0197 NC_012468.1 170414 172330 D identified by match to protein family HMM PF01473; surface protein PspA 170414..172330 Streptococcus pneumoniae 70585 7684154 YP_002739508.1 CDS mnmA NC_012468.1 172731 173852 D catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 172731..173852 Streptococcus pneumoniae 70585 7684279 YP_002739509.1 CDS SP70585_0199 NC_012468.1 173993 174391 D identified by match to protein family HMM PF00293; MutT/nudix family protein 173993..174391 Streptococcus pneumoniae 70585 7685050 YP_002739510.1 CDS gidA NC_012468.1 174458 176371 D GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA 174458..176371 Streptococcus pneumoniae 70585 7684004 YP_002739511.1 CDS SP70585_0201 NC_012468.1 176750 178429 R identified by match to protein family HMM PF00753; match to protein family HMM PF07521; match to protein family HMM TIGR00649; metallo-beta-lactamase superfamily protein complement(176750..178429) Streptococcus pneumoniae 70585 7682986 YP_002739512.1 CDS SP70585_0202 NC_012468.1 178431 178664 R identified by match to protein family HMM PF07288; hypothetical protein complement(178431..178664) Streptococcus pneumoniae 70585 7683026 YP_002739513.1 CDS SP70585_0203 NC_012468.1 179482 179634 R identified by match to protein family HMM TIGR01847; bacteriocin-type signal sequence domain protein complement(179482..179634) Streptococcus pneumoniae 70585 7684701 YP_002739514.1 CDS SP70585_0204 NC_012468.1 179636 179821 R hypothetical protein complement(179636..179821) Streptococcus pneumoniae 70585 7684134 YP_002739515.1 CDS SP70585_0205 NC_012468.1 179999 180682 D identified by match to protein family HMM PF00814; glycoprotein endopeptidase 179999..180682 Streptococcus pneumoniae 70585 7683146 YP_002739516.1 CDS rimI NC_012468.1 180679 181116 D identified by match to protein family HMM PF00583; match to protein family HMM TIGR01575; ribosomal-protein-alanine acetyltransferase 180679..181116 Streptococcus pneumoniae 70585 7684364 YP_002739517.1 CDS SP70585_0207 NC_012468.1 181106 182116 D in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; putative DNA-binding/iron metalloprotein/AP endonuclease 181106..182116 Streptococcus pneumoniae 70585 7684266 YP_002739518.1 CDS SP70585_0208 NC_012468.1 182156 182542 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase complement(182156..182542) Streptococcus pneumoniae 70585 7684494 YP_002739519.1 CDS SP70585_0209 NC_012468.1 182533 183510 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01610; transposase complement(182533..183510) Streptococcus pneumoniae 70585 7683139 YP_002739520.1 CDS SP70585_0210 NC_012468.1 184731 185450 D glycosyl transferase, group 1 family protein 184731..185450 Streptococcus pneumoniae 70585 7685180 YP_002739521.1 CDS SP70585_0211 NC_012468.1 185537 187153 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 185537..187153 Streptococcus pneumoniae 70585 7684990 YP_002739522.1 CDS SP70585_0212 NC_012468.1 187617 187841 D hypothetical protein 187617..187841 Streptococcus pneumoniae 70585 7684541 YP_002739523.1 CDS SP70585_0213 NC_012468.1 187853 188602 D identified by match to protein family HMM PF02585; GlcNAc-PI de-N-acetylase family 187853..188602 Streptococcus pneumoniae 70585 7683382 YP_002739524.1 CDS SP70585_0215 NC_012468.1 190183 191046 D identified by match to protein family HMM TIGR01716; MutR 190183..191046 Streptococcus pneumoniae 70585 7683692 YP_002739525.1 CDS SP70585_0216 NC_012468.1 191337 191534 D identified by glimmer; putative; hypothetical protein 191337..191534 Streptococcus pneumoniae 70585 7683189 YP_002739526.1 CDS SP70585_0217 NC_012468.1 191602 192267 D identified by match to protein family HMM PF02517; caax amino protease family 191602..192267 Streptococcus pneumoniae 70585 7685181 YP_002739527.1 CDS SP70585_0218 NC_012468.1 192339 193565 D transporter major facilitator family protein 192339..193565 Streptococcus pneumoniae 70585 7685000 YP_002739528.1 CDS SP70585_0219 NC_012468.1 193799 194038 R chlorohydrolase complement(193799..194038) Streptococcus pneumoniae 70585 7683818 YP_002739529.1 CDS SP70585_0221 NC_012468.1 194754 195077 D identified by match to protein family HMM PF05437; branched-chain amino acid transport protein AzlD 194754..195077 Streptococcus pneumoniae 70585 7684716 YP_002739530.1 CDS SP70585_0222 NC_012468.1 195181 196011 D identified by match to protein family HMM PF00497; amino acid ABC transporter substrate-binding protein 195181..196011 Streptococcus pneumoniae 70585 7685168 YP_002739531.1 CDS SP70585_0223 NC_012468.1 196165 197019 D identified by match to protein family HMM PF03180; lipoprotein 196165..197019 Streptococcus pneumoniae 70585 7684163 YP_002739532.1 CDS SP70585_0224 NC_012468.1 197119 198492 D identified by match to protein family HMM PF01546; match to protein family HMM PF07687; acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase 197119..198492 Streptococcus pneumoniae 70585 7684592 YP_002739533.1 CDS SP70585_0225 NC_012468.1 198485 199546 D identified by match to protein family HMM PF00005; methionine import ATP-binding protein MetN 198485..199546 Streptococcus pneumoniae 70585 7684325 YP_002739534.1 CDS SP70585_0226 NC_012468.1 199548 200240 D identified by match to protein family HMM PF00528; ABC transporter permease 199548..200240 Streptococcus pneumoniae 70585 7684517 YP_002739535.1 CDS SP70585_0227 NC_012468.1 200269 200838 R identified by match to protein family HMM TIGR02185; membrane-bound protein complement(200269..200838) Streptococcus pneumoniae 70585 7684444 YP_002739536.1 CDS SP70585_0228 NC_012468.1 200973 201587 D identified by match to protein family HMM PF04854; hypothetical protein 200973..201587 Streptococcus pneumoniae 70585 7684521 YP_002739537.1 CDS SP70585_0229 NC_012468.1 201637 203235 D identified by match to protein family HMM PF00672; match to protein family HMM PF02518; match to protein family HMM PF06580; sensor histidine kinase, putative 201637..203235 Streptococcus pneumoniae 70585 7682974 YP_002739538.1 CDS SP70585_0230 NC_012468.1 203247 204533 D identified by match to protein family HMM PF00072; match to protein family HMM PF00165; DNA-binding response regulator 203247..204533 Streptococcus pneumoniae 70585 7683874 YP_002739539.1 CDS SP70585_0231 NC_012468.1 204585 205118 D hypothetical protein 204585..205118 Streptococcus pneumoniae 70585 7685079 YP_002739540.1 CDS SP70585_0232 NC_012468.1 205196 205666 D has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; flavoprotein NrdI 205196..205666 Streptococcus pneumoniae 70585 7683543 YP_002739541.1 CDS SP70585_0233 NC_012468.1 205959 207221 R mn2+ and fe2+ transporter of the nramp family complement(205959..207221) Streptococcus pneumoniae 70585 7684175 YP_002739542.1 CDS SP70585_0234 NC_012468.1 207531 207989 R hypothetical protein complement(207531..207989) Streptococcus pneumoniae 70585 7684883 YP_002739543.1 CDS SP70585_0235 NC_012468.1 207986 208426 R identified by match to protein family HMM PF04397; response regulator of the LytR/AlgR family complement(207986..208426) Streptococcus pneumoniae 70585 7683093 YP_002739544.1 CDS SP70585_0236 NC_012468.1 208542 208721 D hypothetical protein 208542..208721 Streptococcus pneumoniae 70585 7684130 YP_002739545.1 CDS SP70585_0237 NC_012468.1 208693 208893 D MutL 208693..208893 Streptococcus pneumoniae 70585 7683991 YP_002739546.1 CDS ribH NC_012468.1 209218 209685 R RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase complement(209218..209685) Streptococcus pneumoniae 70585 7683222 YP_002739547.1 CDS SP70585_0239 NC_012468.1 209686 210891 R identified by match to protein family HMM PF00925; match to protein family HMM PF00926; match to protein family HMM TIGR00505; match to protein family HMM TIGR00506; riboflavin biosynthesis protein ribAB complement(209686..210891) Streptococcus pneumoniae 70585 7684262 YP_002739548.1 CDS ribE NC_012468.1 210911 211546 R catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha complement(210911..211546) Streptococcus pneumoniae 70585 7684443 YP_002739549.1 CDS ribD NC_012468.1 211531 212631 R identified by match to protein family HMM PF00383; match to protein family HMM PF01872; match to protein family HMM TIGR00227; match to protein family HMM TIGR00326; riboflavin biosynthesis protein RibD complement(211531..212631) Streptococcus pneumoniae 70585 7683773 YP_002739550.1 CDS ruvA NC_012468.1 213035 213628 D plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 213035..213628 Streptococcus pneumoniae 70585 7684861 YP_002739551.1 CDS SP70585_0243 NC_012468.1 213638 214201 D identified by match to protein family HMM PF03352; DNA-3-methyladenine glycosylase 1 213638..214201 Streptococcus pneumoniae 70585 7684760 YP_002739552.1 CDS SP70585_0244 NC_012468.1 214198 214875 D identified by match to protein family HMM PF02517; caax amino protease family 214198..214875 Streptococcus pneumoniae 70585 7684863 YP_002739553.1 CDS SP70585_0245 NC_012468.1 215030 216061 R identified by match to protein family HMM PF02016; MccC family protein complement(215030..216061) Streptococcus pneumoniae 70585 7683873 YP_002739554.1 CDS SP70585_0246 NC_012468.1 216316 216999 R identified by match to protein family HMM PF06570; hypothetical protein complement(216316..216999) Streptococcus pneumoniae 70585 7683973 YP_002739555.1 CDS SP70585_0247 NC_012468.1 217011 217955 R identified by match to protein family HMM PF01544; magnesium and cobalt transporter complement(217011..217955) Streptococcus pneumoniae 70585 7684621 YP_002739556.1 CDS uvrA NC_012468.1 218087 220918 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 218087..220918 Streptococcus pneumoniae 70585 7684270 YP_002739557.1 CDS SP70585_0249 NC_012468.1 220911 221972 D identified by match to protein family HMM PF00557; match to protein family HMM PF01321; Xaa-Pro dipeptidase 220911..221972 Streptococcus pneumoniae 70585 7684321 YP_002739558.1 CDS spxA NC_012468.1 222104 222502 D the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress; transcriptional regulator Spx 222104..222502 Streptococcus pneumoniae 70585 7683747 YP_002739559.1 CDS SP70585_0251 NC_012468.1 222568 223137 D lipoprotein, putative 222568..223137 Streptococcus pneumoniae 70585 7684121 YP_002739560.1 CDS SP70585_0252 NC_012468.1 223224 223490 D identified by match to protein family HMM PF06135; hypothetical protein 223224..223490 Streptococcus pneumoniae 70585 7683472 YP_002739561.1 CDS SP70585_0253 NC_012468.1 223494 223913 D similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 223494..223913 Streptococcus pneumoniae 70585 7683650 YP_002739562.1 CDS SP70585_0254 NC_012468.1 223929 224234 D identified by match to protein family HMM PF06949; hypothetical protein 223929..224234 Streptococcus pneumoniae 70585 7684057 YP_002739563.1 CDS SP70585_0255 NC_012468.1 224442 225692 D identified by match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01499; dihydrofolate:folylpolyglutamate synthetase 224442..225692 Streptococcus pneumoniae 70585 7684211 YP_002739564.1 CDS SP70585_0256 NC_012468.1 225689 226234 D hypothetical protein 225689..226234 Streptococcus pneumoniae 70585 7684653 YP_002739565.1 CDS SP70585_0257 NC_012468.1 226380 227912 D identified by match to protein family HMM PF00614; cardiolipin synthase 226380..227912 Streptococcus pneumoniae 70585 7684012 YP_002739566.1 CDS SP70585_0258 NC_012468.1 228170 229708 D competence-induced protein Ccs4 228170..229708 Streptococcus pneumoniae 70585 7683252 YP_002739567.1 CDS nrdD NC_012468.1 229828 232035 D Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; anaerobic ribonucleoside triphosphate reductase 229828..232035 Streptococcus pneumoniae 70585 7684758 YP_002739568.1 CDS SP70585_0260 NC_012468.1 232047 232187 D hypothetical protein 232047..232187 Streptococcus pneumoniae 70585 7684725 YP_002739569.1 CDS SP70585_0261 NC_012468.1 232231 232737 D identified by match to protein family HMM PF00583; acetyltransferase, gnat family 232231..232737 Streptococcus pneumoniae 70585 7683313 YP_002739570.1 CDS nrdG NC_012468.1 232730 233320 D identified by match to protein family HMM PF04055; match to protein family HMM TIGR02491; anaerobic ribonucleoside-triphosphate reductase activating protein 232730..233320 Streptococcus pneumoniae 70585 7685170 YP_002739571.1 CDS SP70585_0263 NC_012468.1 233317 233934 D identified by match to protein family HMM PF00485; phosphoribulokinase / Uridine kinase family 233317..233934 Streptococcus pneumoniae 70585 7683057 YP_002739572.1 CDS rpsJ NC_012468.1 234210 234518 D NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 234210..234518 Streptococcus pneumoniae 70585 7684985 YP_002739573.1 CDS rplC NC_012468.1 234735 235361 D binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 234735..235361 Streptococcus pneumoniae 70585 7685148 YP_002739574.1 CDS rplD NC_012468.1 235386 236009 D L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 235386..236009 Streptococcus pneumoniae 70585 7683417 YP_002739575.1 CDS rplW NC_012468.1 236009 236305 D binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 236009..236305 Streptococcus pneumoniae 70585 7683521 YP_002739576.1 CDS rplB NC_012468.1 236323 237156 D one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 236323..237156 Streptococcus pneumoniae 70585 7682978 YP_002739577.1 CDS rpsS NC_012468.1 237260 237541 D protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 237260..237541 Streptococcus pneumoniae 70585 7683340 YP_002739578.1 CDS rplV NC_012468.1 237553 237897 D binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 237553..237897 Streptococcus pneumoniae 70585 7684326 YP_002739579.1 CDS rpsC NC_012468.1 237910 238563 D forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 237910..238563 Streptococcus pneumoniae 70585 7683950 YP_002739580.1 CDS rplP NC_012468.1 238567 238980 D located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 238567..238980 Streptococcus pneumoniae 70585 7683981 YP_002739581.1 CDS rpmC NC_012468.1 238990 239196 D one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 238990..239196 Streptococcus pneumoniae 70585 7684156 YP_002739582.1 CDS rpsQ NC_012468.1 239221 239481 D primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 239221..239481 Streptococcus pneumoniae 70585 7684956 YP_002739583.1 CDS rplN NC_012468.1 239507 239875 D binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 239507..239875 Streptococcus pneumoniae 70585 7683565 YP_002739584.1 CDS rplX NC_012468.1 239953 240258 D assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 239953..240258 Streptococcus pneumoniae 70585 7685030 YP_002739585.1 CDS rplE NC_012468.1 240282 240824 D part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 240282..240824 Streptococcus pneumoniae 70585 7684774 YP_002739586.1 CDS rpsN NC_012468.1 240842 241111 D located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 240842..241111 Streptococcus pneumoniae 70585 7683603 YP_002739587.1 CDS rpsH NC_012468.1 241396 241794 D binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 241396..241794 Streptococcus pneumoniae 70585 7682979 YP_002739588.1 CDS rplF NC_012468.1 241986 242522 D ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 241986..242522 Streptococcus pneumoniae 70585 7684895 YP_002739589.1 CDS rplR NC_012468.1 242606 242962 D binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 242606..242962 Streptococcus pneumoniae 70585 7684644 YP_002739590.1 CDS rpsE NC_012468.1 242980 243474 D located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 242980..243474 Streptococcus pneumoniae 70585 7684570 YP_002739591.1 CDS rpmD NC_012468.1 243488 243670 D L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 243488..243670 Streptococcus pneumoniae 70585 7683249 YP_002739592.1 CDS rplO NC_012468.1 243815 244255 D late assembly protein; 50S ribosomal protein L15 243815..244255 Streptococcus pneumoniae 70585 7684374 YP_002739593.1 CDS secY NC_012468.1 244268 245578 D forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 244268..245578 Streptococcus pneumoniae 70585 7684587 YP_002739594.1 CDS adk NC_012468.1 245729 246367 D essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 245729..246367 Streptococcus pneumoniae 70585 7683594 YP_002739595.1 CDS infA NC_012468.1 246484 246702 D stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 246484..246702 Streptococcus pneumoniae 70585 7684702 YP_002739596.1 CDS rpmJ NC_012468.1 246727 246843 D smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif; 50S ribosomal protein L36 246727..246843 Streptococcus pneumoniae 70585 7683167 YP_002739597.1 CDS rpsM NC_012468.1 246861 247226 D located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 246861..247226 Streptococcus pneumoniae 70585 7682998 YP_002739598.1 CDS rpsK NC_012468.1 247244 247627 D located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 247244..247627 Streptococcus pneumoniae 70585 7684571 YP_002739599.1 CDS rpoA NC_012468.1 247670 248605 D catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 247670..248605 Streptococcus pneumoniae 70585 7683569 YP_002739600.1 CDS rplQ NC_012468.1 248617 249003 D is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 248617..249003 Streptococcus pneumoniae 70585 7683204 YP_002739601.1 CDS SP70585_0293 NC_012468.1 249268 249534 D ACT domain-containing protein; hypothetical protein 249268..249534 Streptococcus pneumoniae 70585 7683823 YP_002739602.1 CDS SP70585_0294 NC_012468.1 249544 250881 D identified by match to protein family HMM PF05167; hypothetical protein 249544..250881 Streptococcus pneumoniae 70585 7683582 YP_002739603.1 CDS SP70585_0295 NC_012468.1 251125 251817 D identified by match to protein family HMM PF00300; phosphoglycerate mutase family protein 251125..251817 Streptococcus pneumoniae 70585 7684085 YP_002739604.1 CDS SP70585_0301 NC_012468.1 254649 255098 R iron ABC transporter iron-binding protein complement(254649..255098) Streptococcus pneumoniae 70585 7683867 YP_002739605.1 CDS SP70585_0302 NC_012468.1 255162 255356 R hypothetical protein complement(255162..255356) Streptococcus pneumoniae 70585 7684470 YP_002739606.1 CDS SP70585_0306 NC_012468.1 256742 257125 R Two-component sensor kinase YesM complement(256742..257125) Streptococcus pneumoniae 70585 7683857 YP_002739607.1 CDS SP70585_0307 NC_012468.1 257458 258234 R identified by match to protein family HMM PF04055; match to protein family HMM TIGR02494; pyruvate formate-lyase 3 complement(257458..258234) Streptococcus pneumoniae 70585 7684729 YP_002739608.1 CDS SP70585_0308 NC_012468.1 258356 259102 D identified by match to protein family HMM PF00455; match to protein family HMM PF08220; match to protein family HMM PF08279; putative HTH-type transcriptional regulator YciT 258356..259102 Streptococcus pneumoniae 70585 7684355 YP_002739609.1 CDS SP70585_0309 NC_012468.1 259115 260095 D identified by match to protein family HMM PF04198; transcriptional regulator 259115..260095 Streptococcus pneumoniae 70585 7683140 YP_002739610.1 CDS SP70585_0310 NC_012468.1 260290 260610 D identified by match to protein family HMM PF02255; phosphotransferase system sugar-specific eiia component 260290..260610 Streptococcus pneumoniae 70585 7685115 YP_002739611.1 CDS SP70585_0311 NC_012468.1 260656 260964 D identified by match to protein family HMM PF02302; phosphotransferase system sugar-specific eiib component 260656..260964 Streptococcus pneumoniae 70585 7683106 YP_002739612.1 CDS SP70585_0312 NC_012468.1 260981 262279 D identified by match to protein family HMM PF02378; match to protein family HMM TIGR00410; lichenan permease iic component (pts system lichenan-specific eiiccomponent) (eiic-lic) 260981..262279 Streptococcus pneumoniae 70585 7684203 YP_002739613.1 CDS SP70585_0313 NC_012468.1 262430 264868 D identified by match to protein family HMM PF01228; match to protein family HMM PF02901; match to protein family HMM TIGR01774; pyruvate formate-lyase 262430..264868 Streptococcus pneumoniae 70585 7684043 YP_002739614.1 CDS SP70585_0314 NC_012468.1 264887 265555 D similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase 264887..265555 Streptococcus pneumoniae 70585 7683633 YP_002739615.1 CDS gldA NC_012468.1 265573 266661 D forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone; glycerol dehydrogenase 265573..266661 Streptococcus pneumoniae 70585 7684748 YP_002739616.1 CDS leuS NC_012468.1 267116 269617 D leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 267116..269617 Streptococcus pneumoniae 70585 7683263 YP_002739617.1 CDS SP70585_0317 NC_012468.1 269811 270506 D identified by match to protein family HMM PF00583; acetyltransferase, gnat family 269811..270506 Streptococcus pneumoniae 70585 7682896 YP_002739618.1 CDS SP70585_0318 NC_012468.1 270518 270934 D identified by match to protein family HMM PF00583; acetyltransferase, gnat family 270518..270934 Streptococcus pneumoniae 70585 7684645 YP_002739619.1 CDS ruvB NC_012468.1 271975 272973 D promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 271975..272973 Streptococcus pneumoniae 70585 7684821 YP_002739620.1 CDS SP70585_0320 NC_012468.1 272954 273526 D identified by match to protein family HMM PF06042; hypothetical protein 272954..273526 Streptococcus pneumoniae 70585 7683255 YP_002739621.1 CDS uppS NC_012468.1 273757 274515 D catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; UDP pyrophosphate synthase 273757..274515 Streptococcus pneumoniae 70585 7683246 YP_002739622.1 CDS cdsA NC_012468.1 274524 275327 D identified by match to protein family HMM PF01148; phosphatidate cytidylyltransferase 274524..275327 Streptococcus pneumoniae 70585 7682882 YP_002739623.1 CDS rseP NC_012468.1 275349 276608 D identified by match to protein family HMM PF02163; match to protein family HMM TIGR00054; RIP metalloprotease RseP 275349..276608 Streptococcus pneumoniae 70585 7684480 YP_002739624.1 CDS proS NC_012468.1 276621 278474 D catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 276621..278474 Streptococcus pneumoniae 70585 7683030 YP_002739625.1 CDS SP70585_0325 NC_012468.1 278573 279952 D identified by match to protein family HMM PF00232; glycosyl hydrolase, family 1 278573..279952 Streptococcus pneumoniae 70585 7684058 YP_002739626.1 CDS glmS NC_012468.1 280145 281953 D Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 280145..281953 Streptococcus pneumoniae 70585 7683988 YP_002739627.1 CDS SP70585_0327 NC_012468.1 282072 283121 D identified by match to protein family HMM PF00296; oxidoreductase 282072..283121 Streptococcus pneumoniae 70585 7683230 YP_002739628.1 CDS SP70585_0328 NC_012468.1 283221 287063 R identified by match to protein family HMM PF00128; match to protein family HMM PF00746; match to protein family HMM PF02922; match to protein family HMM PF03714; match to protein family HMM PF04650; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; match to protein family HMM TIGR02102; pullulanase, extracellular complement(283221..287063) Streptococcus pneumoniae 70585 7682897 YP_002739629.1 CDS rpsL NC_012468.1 287480 287893 D interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 287480..287893 Streptococcus pneumoniae 70585 7682887 YP_002739630.1 CDS rpsG NC_012468.1 287913 288383 D binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 287913..288383 Streptococcus pneumoniae 70585 7684912 YP_002739631.1 CDS fusA NC_012468.1 288808 290889 D EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 288808..290889 Streptococcus pneumoniae 70585 7685054 YP_002739632.1 CDS polC NC_012468.1 290993 295384 D catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; required for leading strand synthesis; PolC exhibits 3' to 5' exonuclease activity; DNA polymerase III PolC 290993..295384 Streptococcus pneumoniae 70585 7684418 YP_002739633.1 CDS SP70585_0333 NC_012468.1 295486 295749 D identified by match to protein family HMM PF04221; match to protein family HMM TIGR02384; addiction module antitoxin, RelB/DinJ family 295486..295749 Streptococcus pneumoniae 70585 7683006 YP_002739634.1 CDS SP70585_0334 NC_012468.1 295787 296020 D identified by match to protein family HMM PF05016; match to protein family HMM TIGR02385; DNA damage inducible protein 295787..296020 Streptococcus pneumoniae 70585 7684189 YP_002739635.1 CDS SP70585_0335 NC_012468.1 296041 296193 D hypothetical protein 296041..296193 Streptococcus pneumoniae 70585 7684892 YP_002739636.1 CDS SP70585_0336 NC_012468.1 296215 297456 D identified by match to protein family HMM PF02073; aminopeptidase PepS 296215..297456 Streptococcus pneumoniae 70585 7683105 YP_002739637.1 CDS SP70585_0337 NC_012468.1 297466 297696 D identified by match to protein family HMM PF04226; integral membrane protein 297466..297696 Streptococcus pneumoniae 70585 7683932 YP_002739638.1 CDS SP70585_0338 NC_012468.1 297701 297853 R hypothetical protein complement(297701..297853) Streptococcus pneumoniae 70585 7682952 YP_002739639.1 CDS SP70585_0339 NC_012468.1 297964 298686 D identified by match to protein family HMM PF00849; match to protein family HMM PF01479; match to protein family HMM TIGR00093; ribosomal small subunit pseudouridine synthase A, putative 297964..298686 Streptococcus pneumoniae 70585 7684329 YP_002739640.1 CDS SP70585_0340 NC_012468.1 298903 300237 D identified by match to protein family HMM PF03051; aminopeptidase C (Bleomycin hydrolase) 298903..300237 Streptococcus pneumoniae 70585 7683760 YP_002739641.1 CDS SP70585_0341 NC_012468.1 300293 301204 R identified by match to protein family HMM PF03613; match to protein family HMM TIGR00828; PTS system, mannose/fructose/sorbose family, IID component complement(300293..301204) Streptococcus pneumoniae 70585 7683089 YP_002739642.1 CDS SP70585_0342 NC_012468.1 301228 302031 R identified by match to protein family HMM PF03609; PTS system sorbose-specific IIC component complement(301228..302031) Streptococcus pneumoniae 70585 7684787 YP_002739643.1 CDS SP70585_0343 NC_012468.1 302059 303048 R identified by match to protein family HMM PF03610; match to protein family HMM PF03830; mannose-specific phosphotransferase system component iiab complement(302059..303048) Streptococcus pneumoniae 70585 7685118 YP_002739644.1 CDS SP70585_0344 NC_012468.1 303282 304301 R similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs; alcohol dehydrogenase complement(303282..304301) Streptococcus pneumoniae 70585 7684094 YP_002739645.1 CDS SP70585_0345 NC_012468.1 304643 305455 R identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; Cof family protein complement(304643..305455) Streptococcus pneumoniae 70585 7684558 YP_002739646.1 CDS SP70585_0346 NC_012468.1 305645 307063 D identified by match to protein family HMM PF00860; xanthine/uracil permease family protein 305645..307063 Streptococcus pneumoniae 70585 7684833 YP_002739647.1 CDS SP70585_0347 NC_012468.1 307116 307823 D identified by match to protein family HMM PF02517; caax amino protease family protein 307116..307823 Streptococcus pneumoniae 70585 7684526 YP_002739648.1 CDS folP NC_012468.1 307917 308897 D identified by match to protein family HMM PF00809; match to protein family HMM TIGR01496; dihydropteroate synthase 307917..308897 Streptococcus pneumoniae 70585 7683698 YP_002739649.1 CDS SP70585_0349 NC_012468.1 308899 310221 D identified by match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01499; dihydrofolate synthetase 308899..310221 Streptococcus pneumoniae 70585 7683655 YP_002739650.1 CDS folE NC_012468.1 310202 310756 D involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 310202..310756 Streptococcus pneumoniae 70585 7683936 YP_002739651.1 CDS SP70585_0351 NC_012468.1 310799 311611 D identified by match to protein family HMM PF01288; match to protein family HMM PF02152; match to protein family HMM TIGR00525; match to protein family HMM TIGR00526; match to protein family HMM TIGR01498; bifunctional folate synthesis protein 310799..311611 Streptococcus pneumoniae 70585 7684117 YP_002739652.1 CDS SP70585_0352 NC_012468.1 311656 311973 R hypothetical protein complement(311656..311973) Streptococcus pneumoniae 70585 7684275 YP_002739653.1 CDS rplM NC_012468.1 312329 312775 D in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 312329..312775 Streptococcus pneumoniae 70585 7683320 YP_002739654.1 CDS rpsI NC_012468.1 312794 313186 D forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 312794..313186 Streptococcus pneumoniae 70585 7684754 YP_002739655.1 CDS SP70585_0355 NC_012468.1 313449 314327 R identified by match to protein family HMM PF00589; integrase/recombinase, phage integrase family complement(313449..314327) Streptococcus pneumoniae 70585 7684073 YP_002739656.1 CDS SP70585_0356 NC_012468.1 314569 315258 R identified by glimmer; putative; hypothetical protein complement(314569..315258) Streptococcus pneumoniae 70585 7683820 YP_002739657.1 CDS SP70585_0357 NC_012468.1 315345 315755 R hypothetical protein complement(315345..315755) Streptococcus pneumoniae 70585 7683938 YP_002739658.1 CDS SP70585_0358 NC_012468.1 315812 316702 R identified by glimmer; putative; hypothetical protein complement(315812..316702) Streptococcus pneumoniae 70585 7684106 YP_002739659.1 CDS SP70585_0359 NC_012468.1 316905 317024 D identified by glimmer; putative; hypothetical protein 316905..317024 Streptococcus pneumoniae 70585 7682941 YP_002739660.1 CDS SP70585_0360 NC_012468.1 317025 318116 D identified by glimmer; putative; hypothetical protein 317025..318116 Streptococcus pneumoniae 70585 7684939 YP_002739661.1 CDS SP70585_0361 NC_012468.1 318671 318892 R integrase/recombinase, phage integrase family complement(318671..318892) Streptococcus pneumoniae 70585 7683723 YP_002739662.1 CDS SP70585_0362 NC_012468.1 318997 319128 R hypothetical protein complement(318997..319128) Streptococcus pneumoniae 70585 7684973 YP_002739663.1 CDS SP70585_0363 NC_012468.1 319448 320656 R ATPase complement(319448..320656) Streptococcus pneumoniae 70585 7684604 YP_002739664.1 CDS SP70585_0364 NC_012468.1 320785 321132 D an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01710; transposase 320785..321132 Streptococcus pneumoniae 70585 7683399 YP_002739665.1 CDS SP70585_0365 NC_012468.1 321330 321473 D an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; Spn1, transposase Orf2 321330..321473 Streptococcus pneumoniae 70585 7683763 YP_002739666.1 CDS SP70585_0366 NC_012468.1 321493 321612 D hypothetical protein 321493..321612 Streptococcus pneumoniae 70585 7683428 YP_002739667.1 CDS celA NC_012468.1 321802 323238 D converts 6-phospho-beta-D-glucosyl-(1,4)-D-glucose to glucose and glucose 6-phosphate; required for cellobiose uptake and metabolism; 6-phospho-beta-glucosidase 321802..323238 Streptococcus pneumoniae 70585 7685083 YP_002739668.1 CDS SP70585_0368 NC_012468.1 323290 323529 D identified by match to protein family HMM PF03083; glutathione synthetase 323290..323529 Streptococcus pneumoniae 70585 7684208 YP_002739669.1 CDS celB NC_012468.1 323659 323973 D required for cellobiose uptake and metabolism; cellobiose phosphotransferase system IIB component 323659..323973 Streptococcus pneumoniae 70585 7683021 YP_002739670.1 CDS SP70585_0370 NC_012468.1 324097 326070 D identified by match to protein family HMM PF00874; match to protein family HMM PF05043; match to protein family HMM PF08279; transcription antiterminator BglG family 324097..326070 Streptococcus pneumoniae 70585 7684158 YP_002739671.1 CDS celC NC_012468.1 326080 326394 D required for cellobiose uptake and metabolism; cellobiose phosphotransferase system IIA component 326080..326394 Streptococcus pneumoniae 70585 7684255 YP_002739672.1 CDS SP70585_0372 NC_012468.1 326425 326931 D hypothetical protein 326425..326931 Streptococcus pneumoniae 70585 7683479 YP_002739673.1 CDS celD NC_012468.1 327011 328357 D required for cellobiose uptake and metabolism; cellobiose phosphotransferase system IIC component 327011..328357 Streptococcus pneumoniae 70585 7683968 YP_002739674.1 CDS SP70585_0374 NC_012468.1 328737 328913 D hypothetical protein 328737..328913 Streptococcus pneumoniae 70585 7684356 YP_002739675.1 CDS SP70585_0375 NC_012468.1 329315 331528 D identified by match to protein family HMM PF01055; glycosyl hydrolase, family 31 329315..331528 Streptococcus pneumoniae 70585 7683211 YP_002739676.1 CDS SP70585_0376 NC_012468.1 331554 331931 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01609; transposase (IS4 family) complement(331554..331931) Streptococcus pneumoniae 70585 7683098 YP_002739677.1 CDS SP70585_0377 NC_012468.1 331943 332404 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase complement(331943..332404) Streptococcus pneumoniae 70585 7683839 YP_002739678.1 CDS SP70585_0378 NC_012468.1 332623 333099 R identified by match to protein family HMM PF00255; peroxiredoxin Hyr1 (hydrogen peroxide resistanceprotein 1) (oxidant receptor peroxidase 1) (glutathione peroxidase 3)(phospholipid hydroperoxide glutathione peroxidase 3) (phgpx3) complement(332623..333099) Streptococcus pneumoniae 70585 7685101 YP_002739679.1 CDS SP70585_0379 NC_012468.1 333322 336525 D identified by match to protein family HMM PF00746; match to protein family HMM PF02018; match to protein family HMM PF02278; match to protein family HMM PF02884; match to protein family HMM PF08124; match to protein family HMM TIGR01167; hyaluronate lyase 333322..336525 Streptococcus pneumoniae 70585 7684408 YP_002739680.1 CDS SP70585_0380 NC_012468.1 336939 337292 D an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase 336939..337292 Streptococcus pneumoniae 70585 7683060 YP_002739681.1 CDS SP70585_0381 NC_012468.1 337668 338297 R catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase complement(337668..338297) Streptococcus pneumoniae 70585 7684966 YP_002739682.1 CDS SP70585_0382 NC_012468.1 338307 339308 R identified by match to protein family HMM PF00294; 2-keto-3-deoxygluconate kinase complement(338307..339308) Streptococcus pneumoniae 70585 7684200 YP_002739683.1 CDS SP70585_0383 NC_012468.1 339339 339980 R identified by match to protein family HMM PF02502; hypothetical protein complement(339339..339980) Streptococcus pneumoniae 70585 7683420 YP_002739684.1 CDS SP70585_0384 NC_012468.1 339999 340814 R Involved in the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate; gluconate 5-dehydrogenase complement(339999..340814) Streptococcus pneumoniae 70585 7683955 YP_002739685.1 CDS SP70585_0385 NC_012468.1 341086 341520 D identified by match to protein family HMM PF03610; phosphotransferase system sugar-specific EII component 341086..341520 Streptococcus pneumoniae 70585 7684722 YP_002739686.1 CDS SP70585_0386 NC_012468.1 341532 342722 D identified by match to protein family HMM PF07470; unsaturated glucuronyl hydrolase (UGL) (Glycuronidase)(Unsaturated uronic acid hydrolase) (Glycosaminoglycan hydrolase) 341532..342722 Streptococcus pneumoniae 70585 7684278 YP_002739687.1 CDS SP70585_0387 NC_012468.1 342733 343224 D identified by match to protein family HMM PF03830; N-acetylgalactosamine-specific phosphotransferase enzyme iib component2 (pts system n-acetylgalactosamine-specific eiibcomponent 2) (eiib-aga') 342733..343224 Streptococcus pneumoniae 70585 7683048 YP_002739688.1 CDS SP70585_0388 NC_012468.1 343239 344018 D identified by match to protein family HMM PF03609; phosphotransferase system sugar-specific EII component 343239..344018 Streptococcus pneumoniae 70585 7683556 YP_002739689.1 CDS SP70585_0389 NC_012468.1 344005 344823 D identified by match to protein family HMM PF03613; PTS system, IID component 344005..344823 Streptococcus pneumoniae 70585 7682959 YP_002739690.1 CDS SP70585_0390 NC_012468.1 344859 345116 D preprotein translocase, YajC subunit 344859..345116 Streptococcus pneumoniae 70585 7683322 YP_002739691.1 CDS SP70585_0391 NC_012468.1 345138 347039 D identified by match to protein family HMM PF07940; oligohyaluronate lyase 345138..347039 Streptococcus pneumoniae 70585 7683365 YP_002739692.1 CDS SP70585_0392 NC_012468.1 347099 348100 D identified by match to protein family HMM PF00356; match to protein family HMM PF00532; sugar binding transcriptional regulator RegR 347099..348100 Streptococcus pneumoniae 70585 7684114 YP_002739693.1 CDS SP70585_0393 NC_012468.1 348210 348545 R identified by glimmer; putative; hypothetical protein complement(348210..348545) Streptococcus pneumoniae 70585 7682963 YP_002739694.1 CDS SP70585_0394 NC_012468.1 348556 348798 R hypothetical protein complement(348556..348798) Streptococcus pneumoniae 70585 7685196 YP_002739695.1 CDS SP70585_0395 NC_012468.1 348809 349351 R hypothetical protein complement(348809..349351) Streptococcus pneumoniae 70585 7684847 YP_002739696.1 CDS SP70585_0396 NC_012468.1 349367 349561 R identified by match to protein family HMM PF01381; hypothetical protein complement(349367..349561) Streptococcus pneumoniae 70585 7685125 YP_002739697.1 CDS mraW NC_012468.1 349727 350677 D identified by match to protein family HMM PF01795; match to protein family HMM TIGR00006; S-adenosyl-methyltransferase MraW 349727..350677 Streptococcus pneumoniae 70585 7683559 YP_002739698.1 CDS ftsL NC_012468.1 350689 351006 D identified by match to protein family HMM TIGR02209; cell division protein FtsL 350689..351006 Streptococcus pneumoniae 70585 7684555 YP_002739699.1 CDS SP70585_0399 NC_012468.1 351010 353262 D identified by match to protein family HMM PF00905; match to protein family HMM PF03717; match to protein family HMM PF03793; penicillin-binding protein 2X 351010..353262 Streptococcus pneumoniae 70585 7684717 YP_002739700.1 CDS mraY NC_012468.1 353264 354244 D First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 353264..354244 Streptococcus pneumoniae 70585 7683384 YP_002739701.1 CDS SP70585_0401 NC_012468.1 354456 354572 D hypothetical protein 354456..354572 Streptococcus pneumoniae 70585 7684366 YP_002739702.1 CDS SP70585_0402 NC_012468.1 354853 356958 D identified by match to protein family HMM PF00004; match to protein family HMM PF07724; match to protein family HMM PF07728; ATP-dependent Clp protease ATP-binding subunit ClpL 354853..356958 Streptococcus pneumoniae 70585 7684926 YP_002739703.1 CDS SP70585_0403 NC_012468.1 357464 357745 D GBSi1, group II intron, maturase 357464..357745 Streptococcus pneumoniae 70585 7684636 YP_002739704.1 CDS luxS NC_012468.1 357812 358294 R catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase complement(357812..358294) Streptococcus pneumoniae 70585 7684294 YP_002739705.1 CDS SP70585_0405 NC_012468.1 358389 359873 R identified by match to protein family HMM PF08903; hypothetical protein complement(358389..359873) Streptococcus pneumoniae 70585 7683148 YP_002739706.1 CDS SP70585_0406 NC_012468.1 360026 361633 D identified by match to protein family HMM PF00128; trehalose-6-phosphate hydrolase (Alpha,alpha-phosphotrehalase) 360026..361633 Streptococcus pneumoniae 70585 7684838 YP_002739707.1 CDS SP70585_0408 NC_012468.1 361792 361965 D lipoprotein, putative 361792..361965 Streptococcus pneumoniae 70585 7685110 YP_002739708.1 CDS SP70585_0407 NC_012468.1 361958 362140 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase complement(361958..362140) Streptococcus pneumoniae 70585 7684409 YP_002739709.1 CDS SP70585_0409 NC_012468.1 362188 362313 D identified by glimmer; putative; hypothetical protein 362188..362313 Streptococcus pneumoniae 70585 7684405 YP_002739710.1 CDS SP70585_0410 NC_012468.1 362479 362826 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01710; Spn1 transposase complement(362479..362826) Streptococcus pneumoniae 70585 7683242 YP_002739711.1 CDS SP70585_0411 NC_012468.1 362849 363310 D an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase 362849..363310 Streptococcus pneumoniae 70585 7683138 YP_002739712.1 CDS SP70585_0412 NC_012468.1 363322 363699 D an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01609; transposase (IS4 family) 363322..363699 Streptococcus pneumoniae 70585 7685052 YP_002739713.1 CDS SP70585_0413 NC_012468.1 363930 365375 D identified by match to protein family HMM PF02916; match to protein family HMM PF03816; match to protein family HMM TIGR00350; integral membrane regulatory protein Wzg 363930..365375 Streptococcus pneumoniae 70585 7684984 YP_002739714.1 CDS SP70585_0414 NC_012468.1 365377 366108 D identified by match to protein family HMM PF02811; tyrosine-protein phosphatase CpsB 365377..366108 Streptococcus pneumoniae 70585 7683705 YP_002739715.1 CDS SP70585_0415 NC_012468.1 366117 366809 D identified by match to protein family HMM PF02706; match to protein family HMM TIGR01006; capsular polysaccharide biosynthesis protein Wzd 366117..366809 Streptococcus pneumoniae 70585 7683674 YP_002739716.1 CDS SP70585_0416 NC_012468.1 366819 367493 D identified by match to protein family HMM TIGR01007; tyrosine-protein kinase CpsD 366819..367493 Streptococcus pneumoniae 70585 7684146 YP_002739717.1 CDS SP70585_0417 NC_012468.1 367897 368490 D identified by match to protein family HMM PF02397; capsular polysaccharide biosynthesis protein Cps4E 367897..368490 Streptococcus pneumoniae 70585 7683406 YP_002739718.1 CDS SP70585_0418 NC_012468.1 368499 369725 D identified by match to protein family HMM PF00534; capsular polysaccharide biosynthesis protein Cps4F 368499..369725 Streptococcus pneumoniae 70585 7683729 YP_002739719.1 CDS SP70585_0419 NC_012468.1 369956 371161 D putative repeating unit polymerase 369956..371161 Streptococcus pneumoniae 70585 7683459 YP_002739720.1 CDS SP70585_0420 NC_012468.1 371139 372608 D identified by match to protein family HMM PF01943; match to protein family HMM PF03023; flippase Wzx 371139..372608 Streptococcus pneumoniae 70585 7684197 YP_002739721.1 CDS SP70585_0421 NC_012468.1 372605 373486 D identified by match to protein family HMM PF00535; putative glycosyl transferase 372605..373486 Streptococcus pneumoniae 70585 7684242 YP_002739722.1 CDS SP70585_0422 NC_012468.1 373500 374585 D identified by match to protein family HMM PF00534; putative glycosyltransferase 373500..374585 Streptococcus pneumoniae 70585 7684131 YP_002739723.1 CDS SP70585_0423 NC_012468.1 374578 375384 D hypothetical protein 374578..375384 Streptococcus pneumoniae 70585 7684497 YP_002739724.1 CDS SP70585_0424 NC_012468.1 375618 376655 D identified by match to protein family HMM PF00106; match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF04321; match to protein family HMM PF07993; match to protein family HMM PF08485; trifunctional UDP-D-GlcNAc 4,6-dehdratase/5-epimerase/3-epimerase 375618..376655 Streptococcus pneumoniae 70585 7683551 YP_002739725.1 CDS ugd NC_012468.1 376664 377875 D identified by match to protein family HMM PF00984; match to protein family HMM PF01210; match to protein family HMM PF03720; match to protein family HMM PF03721; match to protein family HMM TIGR03026; UDP-glucose 6-dehydrogenase 376664..377875 Streptococcus pneumoniae 70585 7683885 YP_002739726.1 CDS SP70585_0426 NC_012468.1 377894 379123 D identified by match to protein family HMM PF01370; match to protein family HMM PF07993; UDP-2-acetamido-2,6-dideoxy-b-L-lyxo-4-hexulose 4-reductase 377894..379123 Streptococcus pneumoniae 70585 7685187 YP_002739727.1 CDS SP70585_0427 NC_012468.1 379124 380308 D identified by match to protein family HMM PF02350; match to protein family HMM TIGR00236; UDP-N-acetylglucosamine 2-epimerase 379124..380308 Streptococcus pneumoniae 70585 7684395 YP_002739728.1 CDS SP70585_0428 NC_012468.1 380704 380889 D IS66 family element 380704..380889 Streptococcus pneumoniae 70585 7684559 YP_002739729.1 CDS SP70585_0429 NC_012468.1 380870 381220 D identified by match to protein family HMM PF05717; IS66 family element 380870..381220 Streptococcus pneumoniae 70585 7683571 YP_002739730.1 CDS SP70585_0430 NC_012468.1 381285 381479 D identified by glimmer; putative; hypothetical protein 381285..381479 Streptococcus pneumoniae 70585 7684999 YP_002739731.1 CDS SP70585_0437 NC_012468.1 384486 384599 R hypothetical protein complement(384486..384599) Streptococcus pneumoniae 70585 7684387 YP_002739732.1 CDS SP70585_0438 NC_012468.1 384649 386631 D identified by match to protein family HMM PF00496; oligopeptide binding protein 384649..386631 Streptococcus pneumoniae 70585 7682877 YP_002739733.1 CDS SP70585_0439 NC_012468.1 386932 392235 D identified by match to protein family HMM PF00754; match to protein family HMM PF04650; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; endo-alpha-N-acetylgalactosaminidase 386932..392235 Streptococcus pneumoniae 70585 7684816 YP_002739734.1 CDS SP70585_0440 NC_012468.1 392402 394561 R identified by match to protein family HMM PF00905; match to protein family HMM PF00912; match to protein family HMM TIGR02074; penicillin-binding protein 1A complement(392402..394561) Streptococcus pneumoniae 70585 7684125 YP_002739735.1 CDS recU NC_012468.1 394558 395154 R functions in homologous recombination, DNA repair, and chromosome segregation; binds preferentially to three- and four-stranded DNA intermediates; introduces specific nick sites in four-stranded DNA substrates; functions similarly to Escherichia coli RuvC; Holliday junction-specific endonuclease complement(394558..395154) Streptococcus pneumoniae 70585 7683941 YP_002739736.1 CDS SP70585_0442 NC_012468.1 395220 395747 D identified by match to protein family HMM PF06908; hypothetical protein 395220..395747 Streptococcus pneumoniae 70585 7683541 YP_002739737.1 CDS SP70585_0443 NC_012468.1 395817 396146 D identified by match to protein family HMM PF05103; cell division initiation protein 395817..396146 Streptococcus pneumoniae 70585 7684172 YP_002739738.1 CDS SP70585_0444 NC_012468.1 396632 397789 D identified by match to protein family HMM PF01170; methyltransferase 396632..397789 Streptococcus pneumoniae 70585 7684297 YP_002739739.1 CDS SP70585_0445 NC_012468.1 397801 399195 D hypothetical protein 397801..399195 Streptococcus pneumoniae 70585 7683043 YP_002739740.1 CDS gnd NC_012468.1 399271 400695 D catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase 399271..400695 Streptococcus pneumoniae 70585 7684599 YP_002739741.1 CDS SP70585_0447 NC_012468.1 400707 401396 D identified by match to protein family HMM PF00072; match to protein family HMM PF00486; DNA-binding response regulator 400707..401396 Streptococcus pneumoniae 70585 7684843 YP_002739742.1 CDS SP70585_0448 NC_012468.1 401494 402513 D identified by match to protein family HMM PF01473; choline-binding protein F 401494..402513 Streptococcus pneumoniae 70585 7684859 YP_002739743.1 CDS SP70585_0449 NC_012468.1 402631 403863 R transporter major facilitator family protein complement(402631..403863) Streptococcus pneumoniae 70585 7684932 YP_002739744.1 CDS SP70585_0450 NC_012468.1 404392 404730 R identified by glimmer; putative; hypothetical protein complement(404392..404730) Streptococcus pneumoniae 70585 7684902 YP_002739745.1 CDS SP70585_0451 NC_012468.1 405600 405722 D identified by match to protein family HMM PF01473; choline-binding protein F 405600..405722 Streptococcus pneumoniae 70585 7684721 YP_002739746.1 CDS mvk NC_012468.1 405844 406722 D identified by match to protein family HMM PF00288; match to protein family HMM PF08544; match to protein family HMM TIGR00549; mevalonate kinase 405844..406722 Streptococcus pneumoniae 70585 7683488 YP_002739747.1 CDS mvaD NC_012468.1 406704 407657 D identified by match to protein family HMM PF00288; match to protein family HMM PF08544; match to protein family HMM TIGR01240; diphosphomevalonate decarboxylase 406704..407657 Streptococcus pneumoniae 70585 7684554 YP_002739748.1 CDS SP70585_0454 NC_012468.1 407644 408651 D identified by match to protein family HMM PF00288; match to protein family HMM PF08544; match to protein family HMM TIGR01220; phosphomevalonate kinase 407644..408651 Streptococcus pneumoniae 70585 7684263 YP_002739749.1 CDS fni NC_012468.1 408635 409645 D catalyzes the isomerization of isopentenyl pyrophosphate to dimethylallyl diphosphate; isopentenyl pyrophosphate isomerase 408635..409645 Streptococcus pneumoniae 70585 7684998 YP_002739750.1 CDS SP70585_0456 NC_012468.1 409723 410421 D hypothetical protein 409723..410421 Streptococcus pneumoniae 70585 7682987 YP_002739751.1 CDS SP70585_0457 NC_012468.1 410418 411413 D identified by match to protein family HMM PF02518; match to protein family HMM PF07730; histidine kinase 410418..411413 Streptococcus pneumoniae 70585 7683669 YP_002739752.1 CDS SP70585_0458 NC_012468.1 411427 412059 D identified by match to protein family HMM PF00072; match to protein family HMM PF00196; match to protein family HMM PF08281; response regulator 411427..412059 Streptococcus pneumoniae 70585 7683680 YP_002739753.1 CDS SP70585_0459 NC_012468.1 412273 412527 D identified by glimmer; putative; hypothetical protein 412273..412527 Streptococcus pneumoniae 70585 7685175 YP_002739754.1 CDS SP70585_0460 NC_012468.1 412642 412818 D DNA alkylation repair enzyme 412642..412818 Streptococcus pneumoniae 70585 7684033 YP_002739755.1 CDS SP70585_0461 NC_012468.1 412968 413207 D hypothetical protein 412968..413207 Streptococcus pneumoniae 70585 7683814 YP_002739756.1 CDS SP70585_0464 NC_012468.1 414132 415154 D identified by match to protein family HMM PF01473; choline binding protein F 414132..415154 Streptococcus pneumoniae 70585 7683402 YP_002739757.1 CDS SP70585_0465 NC_012468.1 415282 415770 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF00665; transposase, IS3 family complement(415282..415770) Streptococcus pneumoniae 70585 7683711 YP_002739758.1 CDS SP70585_0466 NC_012468.1 415823 416575 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase complement(415823..416575) Streptococcus pneumoniae 70585 7685005 YP_002739759.1 CDS SP70585_0467 NC_012468.1 416727 418496 D identified by match to protein family HMM PF02302; match to protein family HMM PF02378; match to protein family HMM TIGR00851; pts system mannitol-specific eiicb component (eiicb-mtl) (eii-mtl) 416727..418496 Streptococcus pneumoniae 70585 7684098 YP_002739760.1 CDS SP70585_0468 NC_012468.1 418520 420475 D identified by match to protein family HMM PF08279; putative transcriptional regulator MtlR 418520..420475 Streptococcus pneumoniae 70585 7683634 YP_002739761.1 CDS SP70585_0469 NC_012468.1 420477 420914 D identified by match to protein family HMM PF00359; mannitol-specific phosphotransferase enzyme iia component (pts system mannitol-specific eiia component) (eiia-mtl) (eiii-mtl) 420477..420914 Streptococcus pneumoniae 70585 7684015 YP_002739762.1 CDS SP70585_0470 NC_012468.1 420976 422112 D identified by match to protein family HMM PF01232; match to protein family HMM PF08125; mannitol-1-phosphate 5-dehydrogenase 420976..422112 Streptococcus pneumoniae 70585 7684183 YP_002739763.1 CDS SP70585_0471 NC_012468.1 422494 422607 D hypothetical protein 422494..422607 Streptococcus pneumoniae 70585 7683953 YP_002739764.1 CDS tig NC_012468.1 422920 424203 D Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 422920..424203 Streptococcus pneumoniae 70585 7684509 YP_002739765.1 CDS SP70585_0473 NC_012468.1 424251 426617 R identified by match to protein family HMM TIGR01448; helicase, RecD/TraA family complement(424251..426617) Streptococcus pneumoniae 70585 7684890 YP_002739766.1 CDS lepB NC_012468.1 426745 427359 R identified by match to protein family HMM PF00717; match to protein family HMM TIGR02227; signal peptidase I complement(426745..427359) Streptococcus pneumoniae 70585 7682911 YP_002739767.1 CDS rnhC NC_012468.1 427363 428244 R An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease HIII complement(427363..428244) Streptococcus pneumoniae 70585 7683552 YP_002739768.1 CDS SP70585_0476 NC_012468.1 428409 428633 D hypothetical protein 428409..428633 Streptococcus pneumoniae 70585 7683101 YP_002739769.1 CDS cvpA NC_012468.1 428630 429178 D identified by match to protein family HMM PF02674; CvpA family protein 428630..429178 Streptococcus pneumoniae 70585 7684410 YP_002739770.1 CDS SP70585_0478 NC_012468.1 429282 431618 D identified by match to protein family HMM PF00488; match to protein family HMM PF01713; match to protein family HMM TIGR01069; MutS2 family protein 429282..431618 Streptococcus pneumoniae 70585 7683469 YP_002739771.1 CDS SP70585_0479 NC_012468.1 431961 433283 D identified by match to protein family HMM PF01235; match to protein family HMM TIGR00835; D-alanine glycine permease 431961..433283 Streptococcus pneumoniae 70585 7684087 YP_002739772.1 CDS SP70585_0480 NC_012468.1 433501 434049 D identified by match to protein family HMM PF02627; match to protein family HMM TIGR00778; macrophage infectivity potentiator protein 433501..434049 Streptococcus pneumoniae 70585 7683602 YP_002739773.1 CDS SP70585_0481 NC_012468.1 434158 435057 D identified by match to protein family HMM PF03595; exfoliative toxin A 434158..435057 Streptococcus pneumoniae 70585 7684109 YP_002739774.1 CDS serS NC_012468.1 435082 436356 R catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase complement(435082..436356) Streptococcus pneumoniae 70585 7684046 YP_002739775.1 CDS SP70585_0483 NC_012468.1 436570 436941 R identified by match to protein family HMM PF06115; ManO complement(436570..436941) Streptococcus pneumoniae 70585 7683800 YP_002739776.1 CDS SP70585_0484 NC_012468.1 436944 438308 R catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; lysine and threonine sensitive; aspartate kinase complement(436944..438308) Streptococcus pneumoniae 70585 7683799 YP_002739777.1 CDS SP70585_0485 NC_012468.1 438392 438685 R hypothetical protein complement(438392..438685) Streptococcus pneumoniae 70585 7684396 YP_002739778.1 CDS SP70585_0486 NC_012468.1 438677 439462 D Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 438677..439462 Streptococcus pneumoniae 70585 7684247 YP_002739779.1 CDS SP70585_0487 NC_012468.1 439556 439990 D identified by match to protein family HMM PF01047; match to protein family HMM PF03965; transcriptional regulator 439556..439990 Streptococcus pneumoniae 70585 7684962 YP_002739780.1 CDS SP70585_0488 NC_012468.1 439990 440964 D FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-(acyl carrier protein) synthase III 439990..440964 Streptococcus pneumoniae 70585 7683228 YP_002739781.1 CDS acpP NC_012468.1 441024 441248 D carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 441024..441248 Streptococcus pneumoniae 70585 7683708 YP_002739782.1 CDS SP70585_0490 NC_012468.1 441367 442341 D identified by match to protein family HMM PF03060; match to protein family HMM TIGR03151; enoyl-ACP reductase II 441367..442341 Streptococcus pneumoniae 70585 7684746 YP_002739783.1 CDS fabD NC_012468.1 442334 443254 D identified by match to protein family HMM PF00698; match to protein family HMM TIGR00128; malonyl CoA-acyl carrier protein transacylase 442334..443254 Streptococcus pneumoniae 70585 7683308 YP_002739784.1 CDS fabG NC_012468.1 443288 444019 D catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 443288..444019 Streptococcus pneumoniae 70585 7684602 YP_002739785.1 CDS fabF NC_012468.1 444041 445276 D FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-(acyl carrier protein) synthase II 444041..445276 Streptococcus pneumoniae 70585 7684981 YP_002739786.1 CDS accB NC_012468.1 445279 445764 D composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 445279..445764 Streptococcus pneumoniae 70585 7685178 YP_002739787.1 CDS fabZ NC_012468.1 445761 446183 D in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 445761..446183 Streptococcus pneumoniae 70585 7683136 YP_002739788.1 CDS accC NC_012468.1 446195 447562 D an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxylase subunit 446195..447562 Streptococcus pneumoniae 70585 7682993 YP_002739789.1 CDS accD NC_012468.1 447599 448465 D catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta 447599..448465 Streptococcus pneumoniae 70585 7684703 YP_002739790.1 CDS accA NC_012468.1 448462 449229 D catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; these proteins present a shorter N-terminus; acetyl-CoA carboxylase subunit alpha 448462..449229 Streptococcus pneumoniae 70585 7684449 YP_002739791.1 CDS SP70585_0499 NC_012468.1 449388 449573 D hypothetical protein 449388..449573 Streptococcus pneumoniae 70585 7684223 YP_002739792.1 CDS SP70585_0500 NC_012468.1 449732 449881 D hypothetical protein 449732..449881 Streptococcus pneumoniae 70585 7683609 YP_002739793.1 CDS SP70585_0501 NC_012468.1 449936 450313 D identified by match to protein family HMM PF02517; abortive infection protein 449936..450313 Streptococcus pneumoniae 70585 7684092 YP_002739794.1 CDS nusB NC_012468.1 450362 450784 R Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB complement(450362..450784) Streptococcus pneumoniae 70585 7685031 YP_002739795.1 CDS SP70585_0503 NC_012468.1 450777 451166 R identified by match to protein family HMM PF03780; general stress protein, Gls24 family complement(450777..451166) Streptococcus pneumoniae 70585 7683824 YP_002739796.1 CDS efp NC_012468.1 451188 451748 R Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P complement(451188..451748) Streptococcus pneumoniae 70585 7684983 YP_002739797.1 CDS gatB NC_012468.1 451877 453319 R allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit B complement(451877..453319) Streptococcus pneumoniae 70585 7683779 YP_002739798.1 CDS gatA NC_012468.1 453319 454785 R allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A complement(453319..454785) Streptococcus pneumoniae 70585 7683664 YP_002739799.1 CDS gatC NC_012468.1 454785 455087 R allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain; aspartyl/glutamyl-tRNA amidotransferase subunit C complement(454785..455087) Streptococcus pneumoniae 70585 7683713 YP_002739800.1 CDS prfC NC_012468.1 455300 456844 D stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 455300..456844 Streptococcus pneumoniae 70585 7683210 YP_002739801.1 CDS rpmB NC_012468.1 457872 458060 D required for 70S ribosome assembly; 50S ribosomal protein L28 457872..458060 Streptococcus pneumoniae 70585 7684244 YP_002739802.1 CDS SP70585_0512 NC_012468.1 458217 458582 D identified by match to protein family HMM PF03780; alkaline shock protein 458217..458582 Streptococcus pneumoniae 70585 7683704 YP_002739803.1 CDS SP70585_0513 NC_012468.1 458585 460252 D identified by match to protein family HMM PF02734; dihydroxyacetone kinase family protein 458585..460252 Streptococcus pneumoniae 70585 7683115 YP_002739804.1 CDS ilvB NC_012468.1 460453 462153 D catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; acetolactate synthase catalytic subunit 460453..462153 Streptococcus pneumoniae 70585 7684675 YP_002739805.1 CDS ilvH NC_012468.1 462146 462622 D with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 462146..462622 Streptococcus pneumoniae 70585 7682912 YP_002739806.1 CDS ilvC NC_012468.1 462688 463710 D catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 462688..463710 Streptococcus pneumoniae 70585 7683254 YP_002739807.1 CDS SP70585_0517 NC_012468.1 463817 464053 D hypothetical protein 463817..464053 Streptococcus pneumoniae 70585 7683485 YP_002739808.1 CDS SP70585_0518 NC_012468.1 464291 464647 D hypothetical protein 464291..464647 Streptococcus pneumoniae 70585 7683649 YP_002739809.1 CDS ilvA NC_012468.1 464697 465947 D catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic; threonine dehydratase 464697..465947 Streptococcus pneumoniae 70585 7684532 YP_002739810.1 CDS SP70585_0520 NC_012468.1 466089 466277 D hypothetical protein 466089..466277 Streptococcus pneumoniae 70585 7683355 YP_002739811.1 CDS SP70585_0521 NC_012468.1 466817 467032 D hypothetical protein 466817..467032 Streptococcus pneumoniae 70585 7683563 YP_002739812.1 CDS SP70585_0522 NC_012468.1 467141 467881 R identified by match to protein family HMM PF00005; L-cystine import ATP-binding protein TcyN complement(467141..467881) Streptococcus pneumoniae 70585 7684720 YP_002739813.1 CDS SP70585_0523 NC_012468.1 467881 469446 R identified by match to protein family HMM PF00497; match to protein family HMM PF00528; match to protein family HMM TIGR01726; amino acid ABC transporter permease/substrate-binding protein complement(467881..469446) Streptococcus pneumoniae 70585 7684928 YP_002739814.1 CDS SP70585_0525 NC_012468.1 469584 471473 D hypothetical protein 469584..471473 Streptococcus pneumoniae 70585 7683133 YP_002739815.1 CDS SP70585_0524 NC_012468.1 471470 471640 R hypothetical protein complement(471470..471640) Streptococcus pneumoniae 70585 7685133 YP_002739816.1 CDS SP70585_0526 NC_012468.1 471774 472322 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF02371; transposase complement(471774..472322) Streptococcus pneumoniae 70585 7684818 YP_002739817.1 CDS SP70585_0527 NC_012468.1 472520 472642 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase complement(472520..472642) Streptococcus pneumoniae 70585 7684403 YP_002739818.1 CDS SP70585_0528 NC_012468.1 472898 473743 D BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; UDP pyrophosphate phosphatase 472898..473743 Streptococcus pneumoniae 70585 7684586 YP_002739819.1 CDS SP70585_0529 NC_012468.1 473736 473864 D hypothetical protein 473736..473864 Streptococcus pneumoniae 70585 7684839 YP_002739820.1 CDS dinB NC_012468.1 473890 474951 R involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV complement(473890..474951) Streptococcus pneumoniae 70585 7683431 YP_002739821.1 CDS SP70585_0531 NC_012468.1 474996 475118 R identified by glimmer; putative; hypothetical protein complement(474996..475118) Streptococcus pneumoniae 70585 7683761 YP_002739822.1 CDS pflB NC_012468.1 475345 477669 D identified by match to protein family HMM PF01228; match to protein family HMM PF02901; match to protein family HMM TIGR01255; formate acetyltransferase 475345..477669 Streptococcus pneumoniae 70585 7684989 YP_002739823.1 CDS SP70585_0533 NC_012468.1 478036 478593 R hypothetical protein complement(478036..478593) Streptococcus pneumoniae 70585 7683727 YP_002739824.1 CDS SP70585_0534 NC_012468.1 478586 478870 R hypothetical protein complement(478586..478870) Streptococcus pneumoniae 70585 7685017 YP_002739825.1 CDS SP70585_0535 NC_012468.1 479483 479653 R hypothetical protein complement(479483..479653) Streptococcus pneumoniae 70585 7684229 YP_002739826.1 CDS SP70585_0536 NC_012468.1 480313 481536 R identified by match to protein family HMM PF00480; xylose repressor protein complement(480313..481536) Streptococcus pneumoniae 70585 7685065 YP_002739827.1 CDS SP70585_0537 NC_012468.1 481704 483026 D identified by match to protein family HMM PF02378; match to protein family HMM TIGR00410; lichenan permease iic component (pts system lichenan-specific eiiccomponent) (eiic-lic) 481704..483026 Streptococcus pneumoniae 70585 7684524 YP_002739828.1 CDS SP70585_0538 NC_012468.1 483028 484914 D hypothetical protein 483028..484914 Streptococcus pneumoniae 70585 7683765 YP_002739829.1 CDS SP70585_0539 NC_012468.1 485082 485426 D identified by match to protein family HMM PF02255; lactose-specific phosphotransferase enzyme iia component (pts system lactose-specific eiia component) (eiia-lac) (eiii-lac) 485082..485426 Streptococcus pneumoniae 70585 7684706 YP_002739830.1 CDS lacG1 NC_012468.1 485436 486848 D catalyzes the formation of 6-phospho-galactose from a 6-phospho-beta-galactoside; 6-phospho-beta-galactosidase 485436..486848 Streptococcus pneumoniae 70585 7684029 YP_002739831.1 CDS SP70585_0541 NC_012468.1 486918 488597 D identified by match to protein family HMM PF02302; match to protein family HMM PF02378; pts system lactose-specific eiicb component (eiicb-lac) (eii-lac) 486918..488597 Streptococcus pneumoniae 70585 7683808 YP_002739832.1 CDS SP70585_0542 NC_012468.1 488723 490162 R identified by match to protein family HMM PF02386; Trk transporter membrane-spanning protein - K+ transport complement(488723..490162) Streptococcus pneumoniae 70585 7683238 YP_002739833.1 CDS trkA NC_012468.1 490166 491515 R involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane component complement(490166..491515) Streptococcus pneumoniae 70585 7684695 YP_002739834.1 CDS SP70585_0544 NC_012468.1 491704 492552 D identified by match to protein family HMM PF01887; hypothetical protein 491704..492552 Streptococcus pneumoniae 70585 7684145 YP_002739835.1 CDS SP70585_0545 NC_012468.1 492567 493115 D identified by match to protein family HMM PF07155; hypothetical protein 492567..493115 Streptococcus pneumoniae 70585 7684076 YP_002739836.1 CDS SP70585_0546 NC_012468.1 493122 493424 D chlorohydrolase 493122..493424 Streptococcus pneumoniae 70585 7684176 YP_002739837.1 CDS SP70585_0547 NC_012468.1 493526 495208 D identified by match to protein family HMM PF00005; putative ABC transporter ATP-binding protein 493526..495208 Streptococcus pneumoniae 70585 7683561 YP_002739838.1 CDS SP70585_0548 NC_012468.1 495193 496023 D identified by match to protein family HMM PF02361; cobalt transport family protein 495193..496023 Streptococcus pneumoniae 70585 7684460 YP_002739839.1 CDS cspR NC_012468.1 496216 496719 D identified by match to protein family HMM PF00588; CspR 496216..496719 Streptococcus pneumoniae 70585 7684992 YP_002739840.1 CDS SP70585_0550 NC_012468.1 497172 497735 D hypothetical protein 497172..497735 Streptococcus pneumoniae 70585 7683176 YP_002739841.1 CDS SP70585_0551 NC_012468.1 497749 498375 D identified by match to protein family HMM PF01569; PAP2 family protein 497749..498375 Streptococcus pneumoniae 70585 7683319 YP_002739842.1 CDS SP70585_0552 NC_012468.1 498402 498791 D hypothetical protein 498402..498791 Streptococcus pneumoniae 70585 7684764 YP_002739843.1 CDS SP70585_0553 NC_012468.1 498796 499245 D hypothetical protein 498796..499245 Streptococcus pneumoniae 70585 7683567 YP_002739844.1 CDS rpoE NC_012468.1 499373 499960 D participates in both the initiation and recycling phases of transcription; in the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling; DNA-directed RNA polymerase subunit delta 499373..499960 Streptococcus pneumoniae 70585 7683165 YP_002739845.1 CDS SP70585_0555 NC_012468.1 500050 500187 R identified by glimmer; putative; hypothetical protein complement(500050..500187) Streptococcus pneumoniae 70585 7684778 YP_002739846.1 CDS pyrG NC_012468.1 500350 501957 D CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 500350..501957 Streptococcus pneumoniae 70585 7684607 YP_002739847.1 CDS SP70585_0557 NC_012468.1 502516 504147 R identified by match to protein family HMM PF01895; match to protein family HMM PF02690; match to protein family HMM TIGR00704; sodium-dependent phosphate transporter complement(502516..504147) Streptococcus pneumoniae 70585 7683398 YP_002739848.1 CDS SP70585_0558 NC_012468.1 504512 509380 D identified by match to protein family HMM PF00746; match to protein family HMM PF00754; match to protein family HMM PF03644; match to protein family HMM PF07501; match to protein family HMM PF07523; match to protein family HMM TIGR01167; endo-beta-N-acetylglucosaminidase D 504512..509380 Streptococcus pneumoniae 70585 7685046 YP_002739849.1 CDS pgk NC_012468.1 509470 510666 D Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 509470..510666 Streptococcus pneumoniae 70585 7683794 YP_002739850.1 CDS SP70585_0560 NC_012468.1 510802 511329 D hypothetical protein 510802..511329 Streptococcus pneumoniae 70585 7683786 YP_002739851.1 CDS SP70585_0561 NC_012468.1 511406 511762 D identified by match to protein family HMM PF00376; HTH-type transcriptional regulator GlnR 511406..511762 Streptococcus pneumoniae 70585 7683460 YP_002739852.1 CDS glnA NC_012468.1 511799 513145 D identified by match to protein family HMM PF00120; match to protein family HMM PF03951; match to protein family HMM TIGR00653; glutamine synthetase, type I 511799..513145 Streptococcus pneumoniae 70585 7684741 YP_002739853.1 CDS SP70585_0563 NC_012468.1 513235 513354 R hypothetical protein complement(513235..513354) Streptococcus pneumoniae 70585 7684344 YP_002739854.1 CDS SP70585_0564 NC_012468.1 513319 513468 D identified by glimmer; putative; hypothetical protein 513319..513468 Streptococcus pneumoniae 70585 7682946 YP_002739855.1 CDS SP70585_0565 NC_012468.1 513612 513749 D hypothetical protein 513612..513749 Streptococcus pneumoniae 70585 7683970 YP_002739856.1 CDS SP70585_0566 NC_012468.1 515163 516713 R identified by match to protein family HMM PF01420; type I restriction enzyme complement(515163..516713) Streptococcus pneumoniae 70585 7684947 YP_002739857.1 CDS SP70585_0567 NC_012468.1 516713 518176 R identified by match to protein family HMM PF02384; type I restriction enzyme complement(516713..518176) Streptococcus pneumoniae 70585 7682889 YP_002739858.1 CDS SP70585_0568 NC_012468.1 518189 520522 R identified by match to protein family HMM PF00270; match to protein family HMM PF04313; match to protein family HMM PF04851; match to protein family HMM PF08463; type I restriction-modification system, R subunit complement(518189..520522) Streptococcus pneumoniae 70585 7684648 YP_002739859.1 CDS SP70585_0569 NC_012468.1 520900 521094 D hypothetical protein 520900..521094 Streptococcus pneumoniae 70585 7683828 YP_002739860.1 CDS SP70585_0570 NC_012468.1 521129 521638 D hypothetical protein 521129..521638 Streptococcus pneumoniae 70585 7685131 YP_002739861.1 CDS hrcA NC_012468.1 521802 522836 D Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons; heat-inducible transcription repressor 521802..522836 Streptococcus pneumoniae 70585 7683368 YP_002739862.1 CDS grpE NC_012468.1 522863 523387 D with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 522863..523387 Streptococcus pneumoniae 70585 7683855 YP_002739863.1 CDS dnaK NC_012468.1 523856 525679 D heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 523856..525679 Streptococcus pneumoniae 70585 7683599 YP_002739864.1 CDS SP70585_0574 NC_012468.1 525690 526094 D hypothetical protein 525690..526094 Streptococcus pneumoniae 70585 7683197 YP_002739865.1 CDS dnaJ NC_012468.1 526438 527574 D chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ 526438..527574 Streptococcus pneumoniae 70585 7683188 YP_002739866.1 CDS SP70585_0576 NC_012468.1 527881 528120 R chlorohydrolase complement(527881..528120) Streptococcus pneumoniae 70585 7684980 YP_002739867.1 CDS SP70585_0577 NC_012468.1 528282 528569 R hypothetical protein complement(528282..528569) Streptococcus pneumoniae 70585 7684007 YP_002739868.1 CDS SP70585_0578 NC_012468.1 528579 528989 R identified by match to protein family HMM PF01230; histidine triad domain protein complement(528579..528989) Streptococcus pneumoniae 70585 7683374 YP_002739869.1 CDS SP70585_0579 NC_012468.1 529057 529788 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 529057..529788 Streptococcus pneumoniae 70585 7684424 YP_002739870.1 CDS SP70585_0580 NC_012468.1 529785 530834 D identified by match to protein family HMM PF05975; ABC transporter permease 529785..530834 Streptococcus pneumoniae 70585 7683944 YP_002739871.1 CDS SP70585_0581 NC_012468.1 531002 531331 R BlpT protein, fusion complement(531002..531331) Streptococcus pneumoniae 70585 7683858 YP_002739872.1 CDS SP70585_0582 NC_012468.1 531607 531945 D identified by match to protein family HMM PF04397; BlpS protein 531607..531945 Streptococcus pneumoniae 70585 7684783 YP_002739873.1 CDS SP70585_0583 NC_012468.1 531950 532687 D identified by match to protein family HMM PF00072; match to protein family HMM PF04397; response regulator 531950..532687 Streptococcus pneumoniae 70585 7683720 YP_002739874.1 CDS SP70585_0584 NC_012468.1 532701 534041 D identified by match to protein family HMM PF02518; histidine kinase 532701..534041 Streptococcus pneumoniae 70585 7683435 YP_002739875.1 CDS SP70585_0585 NC_012468.1 534083 534238 R identified by match to protein family HMM PF08128; match to protein family HMM TIGR01847; double glycine cleavage site bacteriolysin superfamily complement(534083..534238) Streptococcus pneumoniae 70585 7683224 YP_002739876.1 CDS SP70585_0586 NC_012468.1 534295 535656 R identified by match to protein family HMM TIGR01000; BlpC ABC transporter complement(534295..535656) Streptococcus pneumoniae 70585 7684261 YP_002739877.1 CDS SP70585_0589 NC_012468.1 538106 538303 D hypothetical protein 538106..538303 Streptococcus pneumoniae 70585 7683592 YP_002739878.1 CDS SP70585_0590 NC_012468.1 538770 539039 D identified by match to protein family HMM TIGR01847; bacteriocin BlpJ 538770..539039 Streptococcus pneumoniae 70585 7684140 YP_002739879.1 CDS SP70585_0591 NC_012468.1 539108 539338 D identified by match to protein family HMM TIGR01847; hypothetical protein 539108..539338 Streptococcus pneumoniae 70585 7683694 YP_002739880.1 CDS SP70585_0592 NC_012468.1 539341 539460 D identified by glimmer; putative; hypothetical protein 539341..539460 Streptococcus pneumoniae 70585 7683632 YP_002739881.1 CDS SP70585_0593 NC_012468.1 539573 539689 D hypothetical protein 539573..539689 Streptococcus pneumoniae 70585 7682901 YP_002739882.1 CDS SP70585_0594 NC_012468.1 539757 539921 D hypothetical protein 539757..539921 Streptococcus pneumoniae 70585 7683279 YP_002739883.1 CDS SP70585_0595 NC_012468.1 539918 540322 D immunity protein BlpL 539918..540322 Streptococcus pneumoniae 70585 7684431 YP_002739884.1 CDS SP70585_0596 NC_012468.1 540387 540848 D an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase 540387..540848 Streptococcus pneumoniae 70585 7685117 YP_002739885.1 CDS SP70585_0597 NC_012468.1 540860 541237 D an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01609; transposase (IS4 family) 540860..541237 Streptococcus pneumoniae 70585 7684017 YP_002739886.1 CDS SP70585_0598 NC_012468.1 541398 541721 D an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; mobile genetic element 541398..541721 Streptococcus pneumoniae 70585 7684214 YP_002739887.1 CDS SP70585_0599 NC_012468.1 541815 542204 D identified by match to protein family HMM PF01609; transposase (IS4 family) 541815..542204 Streptococcus pneumoniae 70585 7684565 YP_002739888.1 CDS SP70585_0600 NC_012468.1 542354 542608 D identified by match to protein family HMM TIGR01847; bacteriocin BlpM 542354..542608 Streptococcus pneumoniae 70585 7683682 YP_002739889.1 CDS SP70585_0601 NC_012468.1 542624 542827 D hypothetical protein 542624..542827 Streptococcus pneumoniae 70585 7683478 YP_002739890.1 CDS SP70585_0602 NC_012468.1 543071 543220 D identified by match to protein family HMM TIGR01847; BlpO protein 543071..543220 Streptococcus pneumoniae 70585 7684529 YP_002739891.1 CDS SP70585_0603 NC_012468.1 543202 543321 D hypothetical protein 543202..543321 Streptococcus pneumoniae 70585 7684055 YP_002739892.1 CDS SP70585_0604 NC_012468.1 543324 543443 D hypothetical protein 543324..543443 Streptococcus pneumoniae 70585 7684948 YP_002739893.1 CDS SP70585_0605 NC_012468.1 543778 543957 D hypothetical protein 543778..543957 Streptococcus pneumoniae 70585 7683086 YP_002739894.1 CDS SP70585_0606 NC_012468.1 544229 544612 D immunity protein BlpX 544229..544612 Streptococcus pneumoniae 70585 7683239 YP_002739895.1 CDS SP70585_0607 NC_012468.1 544664 545353 D identified by match to protein family HMM PF02517; BlpY protein 544664..545353 Streptococcus pneumoniae 70585 7684054 YP_002739896.1 CDS SP70585_0608 NC_012468.1 545395 545643 D BlpZ 545395..545643 Streptococcus pneumoniae 70585 7682892 YP_002739897.1 CDS SP70585_0609 NC_012468.1 545673 546284 D identified by match to protein family HMM PF02517; ABC transporter ATP-binding protein 545673..546284 Streptococcus pneumoniae 70585 7683251 YP_002739898.1 CDS SP70585_0610 NC_012468.1 546446 547240 D identified by match to protein family HMM PF01636; phosphotransferase enzyme family 546446..547240 Streptococcus pneumoniae 70585 7684336 YP_002739899.1 CDS trmB NC_012468.1 547237 547872 D tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 547237..547872 Streptococcus pneumoniae 70585 7683809 YP_002739900.1 CDS SP70585_0612 NC_012468.1 547927 548478 D in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein 547927..548478 Streptococcus pneumoniae 70585 7684572 YP_002739901.1 CDS nusA NC_012468.1 548522 549658 D modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 548522..549658 Streptococcus pneumoniae 70585 7683113 YP_002739902.1 CDS SP70585_0614 NC_012468.1 549680 549973 D identified by match to protein family HMM PF04296; putative chain a, hypothetical cytosolic protein coded by gene from nusainfb, ylxr homologue 549680..549973 Streptococcus pneumoniae 70585 7683010 YP_002739903.1 CDS SP70585_0615 NC_012468.1 549966 550265 D identified by match to protein family HMM PF01248; hypothetical protein 549966..550265 Streptococcus pneumoniae 70585 7684659 YP_002739904.1 CDS infB NC_012468.1 550282 553074 D Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 550282..553074 Streptococcus pneumoniae 70585 7682927 YP_002739905.1 CDS rbfA NC_012468.1 553325 553675 D associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A 553325..553675 Streptococcus pneumoniae 70585 7683505 YP_002739906.1 CDS SP70585_0618 NC_012468.1 553735 554262 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase complement(553735..554262) Streptococcus pneumoniae 70585 7683638 YP_002739907.1 CDS SP70585_0619 NC_012468.1 554543 555061 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase complement(554543..555061) Streptococcus pneumoniae 70585 7682902 YP_002739908.1 CDS SP70585_0622 NC_012468.1 556231 556413 D hypothetical protein 556231..556413 Streptococcus pneumoniae 70585 7683596 YP_002739909.1 CDS SP70585_0623 NC_012468.1 556410 556550 D hypothetical protein 556410..556550 Streptococcus pneumoniae 70585 7683310 YP_002739910.1 CDS SP70585_0624 NC_012468.1 556629 557090 D an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase 556629..557090 Streptococcus pneumoniae 70585 7684742 YP_002739911.1 CDS SP70585_0625 NC_012468.1 557102 557479 D an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01609; transposase (IS4 family) 557102..557479 Streptococcus pneumoniae 70585 7683578 YP_002739912.1 CDS SP70585_0626 NC_012468.1 557691 557924 D identified by match to protein family HMM PF08984; hypothetical protein 557691..557924 Streptococcus pneumoniae 70585 7684099 YP_002739913.1 CDS SP70585_0627 NC_012468.1 557924 559258 D identified by match to protein family HMM PF01814; match to protein family HMM PF04282; hemerythrin HHE cation binding domain subfamily, putative 557924..559258 Streptococcus pneumoniae 70585 7684657 YP_002739914.1 CDS SP70585_0628 NC_012468.1 559268 559522 D identified by match to protein family HMM PF08930; hypothetical protein 559268..559522 Streptococcus pneumoniae 70585 7682899 YP_002739915.1 CDS SP70585_0629 NC_012468.1 559618 560013 D superfamily II helicase 559618..560013 Streptococcus pneumoniae 70585 7683338 YP_002739916.1 CDS SP70585_0630 NC_012468.1 560426 560875 D conserved protein/domain typically associated with flavoprotein oxygenase, Dim6/ntab family 560426..560875 Streptococcus pneumoniae 70585 7683854 YP_002739917.1 CDS SP70585_0631 NC_012468.1 560862 561422 D identified by match to protein family HMM PF00583; acetyltransferase, gnat family 560862..561422 Streptococcus pneumoniae 70585 7684594 YP_002739918.1 CDS SP70585_0632 NC_012468.1 561422 562000 D shikimate kinase 561422..562000 Streptococcus pneumoniae 70585 7684331 YP_002739919.1 CDS valS NC_012468.1 561993 564644 D valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 561993..564644 Streptococcus pneumoniae 70585 7684442 YP_002739920.1 CDS SP70585_0634 NC_012468.1 564714 565469 D hypothetical protein 564714..565469 Streptococcus pneumoniae 70585 7683946 YP_002739921.1 CDS SP70585_0635 NC_012468.1 565746 566549 D identified by match to protein family HMM PF02661; Fic protein family 565746..566549 Streptococcus pneumoniae 70585 7684982 YP_002739922.1 CDS SP70585_0639 NC_012468.1 567712 567924 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase complement(567712..567924) Streptococcus pneumoniae 70585 7683645 YP_002739923.1 CDS SP70585_0640 NC_012468.1 568466 569305 D identified by match to protein family HMM PF00874; match to protein family HMM PF03123; transcription antiterminator LicT 568466..569305 Streptococcus pneumoniae 70585 7683784 YP_002739924.1 CDS SP70585_0641 NC_012468.1 569323 571161 D identified by match to protein family HMM PF00358; match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00830; match to protein family HMM TIGR01995; pts system beta-glucoside-specific eiibca component (eiibca-bgl) (eii-bgl) 569323..571161 Streptococcus pneumoniae 70585 7682888 YP_002739925.1 CDS SP70585_0642 NC_012468.1 571174 572589 D identified by match to protein family HMM PF00232; beta-glucosidase (Gentiobiase) (Cellobiase) (Beta-D-glucoside glucohydrolase) (Amygdalase) 571174..572589 Streptococcus pneumoniae 70585 7684647 YP_002739926.1 CDS pheS NC_012468.1 573181 574227 D catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 573181..574227 Streptococcus pneumoniae 70585 7683361 YP_002739927.1 CDS SP70585_0644 NC_012468.1 574227 574736 D identified by match to protein family HMM PF00583; protease synthase and sporulation negative regulatory protein PAI 1 574227..574736 Streptococcus pneumoniae 70585 7684105 YP_002739928.1 CDS pheT NC_012468.1 574813 577218 D catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 574813..577218 Streptococcus pneumoniae 70585 7682991 YP_002739929.1 CDS SP70585_0646 NC_012468.1 577286 578287 R identified by match to protein family HMM PF03372; endonuclease/exonuclease/phosphatase family complement(577286..578287) Streptococcus pneumoniae 70585 7683810 YP_002739930.1 CDS SP70585_0647 NC_012468.1 578443 578766 D an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase 578443..578766 Streptococcus pneumoniae 70585 7684676 YP_002739931.1 CDS SP70585_0648 NC_012468.1 578763 578891 D an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase 578763..578891 Streptococcus pneumoniae 70585 7682961 YP_002739932.1 CDS SP70585_0649 NC_012468.1 579014 579280 D identified by match to protein family HMM PF01381; helix-turn-helix domain protein 579014..579280 Streptococcus pneumoniae 70585 7684963 YP_002739933.1 CDS metE NC_012468.1 579540 581789 D catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 579540..581789 Streptococcus pneumoniae 70585 7682923 YP_002739934.1 CDS metF NC_012468.1 581853 582719 D identified by match to protein family HMM PF02219; match to protein family HMM TIGR00676; 5,10-methylenetetrahydrofolate reductase 581853..582719 Streptococcus pneumoniae 70585 7683739 YP_002739935.1 CDS SP70585_0652 NC_012468.1 583278 585491 D identified by match to protein family HMM PF00013; match to protein family HMM PF00575; match to protein family HMM PF01138; match to protein family HMM PF03725; match to protein family HMM PF03726; polynucleotide phosphorylase/polyadenylase 583278..585491 Streptococcus pneumoniae 70585 7683309 YP_002739936.1 CDS cysE NC_012468.1 585507 586124 D identified by match to protein family HMM TIGR01172; serine O-acetyltransferase 585507..586124 Streptococcus pneumoniae 70585 7683157 YP_002739937.1 CDS SP70585_0654 NC_012468.1 586136 587020 D identified by match to protein family HMM PF00583; acetyltransferase, gnat family 586136..587020 Streptococcus pneumoniae 70585 7685105 YP_002739938.1 CDS cysS NC_012468.1 587107 588450 D catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 587107..588450 Streptococcus pneumoniae 70585 7684351 YP_002739939.1 CDS SP70585_0656 NC_012468.1 588443 588829 D identified by match to protein family HMM PF00636; ribonuclease III family protein 588443..588829 Streptococcus pneumoniae 70585 7683073 YP_002739940.1 CDS SP70585_0657 NC_012468.1 588833 589717 D leucine-rich protein 588833..589717 Streptococcus pneumoniae 70585 7683327 YP_002739941.1 CDS SP70585_0658 NC_012468.1 589854 590309 D hypothetical protein 589854..590309 Streptococcus pneumoniae 70585 7682937 YP_002739942.1 CDS SP70585_0659 NC_012468.1 590306 590452 D hypothetical protein 590306..590452 Streptococcus pneumoniae 70585 7683013 YP_002739943.1 CDS SP70585_0660 NC_012468.1 590598 590771 D GBSi1, group II intron, maturase 590598..590771 Streptococcus pneumoniae 70585 7683154 YP_002739944.1 CDS SP70585_0661 NC_012468.1 591123 592400 D identified by match to protein family HMM PF02687; peptide ABC transporter permease 591123..592400 Streptococcus pneumoniae 70585 7684293 YP_002739945.1 CDS SP70585_0662 NC_012468.1 592413 593060 D identified by match to protein family HMM PF00005; peptide ABC transporter ATP-binding protein 592413..593060 Streptococcus pneumoniae 70585 7683587 YP_002739946.1 CDS SP70585_0663 NC_012468.1 593112 594491 D identified by match to protein family HMM PF02687; peptide ABC transporter permease 593112..594491 Streptococcus pneumoniae 70585 7683613 YP_002739947.1 CDS SP70585_0664 NC_012468.1 594662 594787 D identified by glimmer; putative; hypothetical protein 594662..594787 Streptococcus pneumoniae 70585 7683325 YP_002739948.1 CDS SP70585_0665 NC_012468.1 594802 595458 D identified by match to protein family HMM PF00072; match to protein family HMM PF00486; VncR, response regulator 594802..595458 Streptococcus pneumoniae 70585 7683754 YP_002739949.1 CDS SP70585_0666 NC_012468.1 595455 596783 D identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; VncS, histidine kinase 595455..596783 Streptococcus pneumoniae 70585 7683419 YP_002739950.1 CDS fba NC_012468.1 596924 597805 D catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase 596924..597805 Streptococcus pneumoniae 70585 7684575 YP_002739951.1 CDS SP70585_0668 NC_012468.1 598126 599316 R identified by match to protein family HMM PF00175; match to protein family HMM PF00970; match to protein family HMM PF01794; oxidoreductase, NAD-binding complement(598126..599316) Streptococcus pneumoniae 70585 7684389 YP_002739952.1 CDS SP70585_0669 NC_012468.1 599611 600270 R identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; glutamine ABC transporter permease complement(599611..600270) Streptococcus pneumoniae 70585 7684916 YP_002739953.1 CDS SP70585_0670 NC_012468.1 600280 600957 R identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; glutamine ABC transporter permease complement(600280..600957) Streptococcus pneumoniae 70585 7684819 YP_002739954.1 CDS SP70585_0671 NC_012468.1 600970 601734 R identified by match to protein family HMM PF00497; amino acid ABC transporter substrate-binding protein complement(600970..601734) Streptococcus pneumoniae 70585 7683292 YP_002739955.1 CDS SP70585_0672 NC_012468.1 601774 602532 R identified by match to protein family HMM PF00005; glutamine transport ATP-binding protein GlnQ complement(601774..602532) Streptococcus pneumoniae 70585 7684507 YP_002739956.1 CDS recJ NC_012468.1 602809 605031 D identified by match to protein family HMM PF01368; match to protein family HMM PF02272; match to protein family HMM TIGR00644; single-stranded-DNA-specific exonuclease RecJ 602809..605031 Streptococcus pneumoniae 70585 7683604 YP_002739957.1 CDS SP70585_0674 NC_012468.1 605206 606867 D identified by match to protein family HMM PF00753; match to protein family HMM PF07521; metallo-beta-lactamase family protein 605206..606867 Streptococcus pneumoniae 70585 7683815 YP_002739958.1 CDS SP70585_0675 NC_012468.1 606936 607715 D identified by match to protein family HMM PF00756; tributyrin esterase 606936..607715 Streptococcus pneumoniae 70585 7685144 YP_002739959.1 CDS SP70585_0676 NC_012468.1 607827 609047 D identified by match to protein family HMM PF02388; serine/alanine-adding enzyme MurM 607827..609047 Streptococcus pneumoniae 70585 7683942 YP_002739960.1 CDS SP70585_0677 NC_012468.1 609052 610284 D identified by match to protein family HMM PF02388; beta-lactam resistance factor 609052..610284 Streptococcus pneumoniae 70585 7684552 YP_002739961.1 CDS SP70585_0678 NC_012468.1 610363 611064 D identified by match to protein family HMM PF00413; matrixin family 610363..611064 Streptococcus pneumoniae 70585 7684793 YP_002739962.1 CDS uvrC NC_012468.1 611104 612948 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 611104..612948 Streptococcus pneumoniae 70585 7684697 YP_002739963.1 CDS SP70585_0680 NC_012468.1 612980 613771 D hypothetical protein 612980..613771 Streptococcus pneumoniae 70585 7684398 YP_002739964.1 CDS SP70585_0681 NC_012468.1 613953 614753 R identified by match to protein family HMM PF00497; ABC transporter substrate-binding protein - glutamine transport/Major cell binding factor complement(613953..614753) Streptococcus pneumoniae 70585 7682967 YP_002739965.1 CDS SP70585_0682 NC_012468.1 614924 615529 D identified by match to protein family HMM PF00881; oxidoreductase 614924..615529 Streptococcus pneumoniae 70585 7684775 YP_002739966.1 CDS pepV NC_012468.1 615542 616942 D divalent metal ion-dependent extracellular dipeptidase; able to hydrolyze a broad range of dipeptides but no tri-, tetra-, or larger oligopeptides; differences in the amino acid specificity of the cleavage site varies between species; similar to succinyl-diaminopimelate desuccinylases; dipeptidase PepV 615542..616942 Streptococcus pneumoniae 70585 7683050 YP_002739967.1 CDS SP70585_0684 NC_012468.1 616996 617574 D identified by match to protein family HMM PF03167; uracil DNA glycosylase family protein 616996..617574 Streptococcus pneumoniae 70585 7682971 YP_002739968.1 CDS SP70585_0685 NC_012468.1 617734 617886 D hypothetical protein 617734..617886 Streptococcus pneumoniae 70585 7683271 YP_002739969.1 CDS SP70585_0686 NC_012468.1 617902 618021 D molybdopterin biosynthesis MoeB protein 617902..618021 Streptococcus pneumoniae 70585 7685045 YP_002739970.1 CDS brnQ NC_012468.1 618192 619517 D identified by match to protein family HMM PF05525; match to protein family HMM TIGR00796; branched-chain amino acid transport system II carrier protein 618192..619517 Streptococcus pneumoniae 70585 7683123 YP_002739971.1 CDS SP70585_0688 NC_012468.1 619615 620652 D identified by match to protein family HMM PF05343; peptidase, M42 619615..620652 Streptococcus pneumoniae 70585 7683036 YP_002739972.1 CDS SP70585_0689 NC_012468.1 620654 621115 D identified by match to protein family HMM PF01230; HIT family protein 620654..621115 Streptococcus pneumoniae 70585 7684239 YP_002739973.1 CDS SP70585_0690 NC_012468.1 621133 621849 D identified by match to protein family HMM PF02557; D-alanyl-D-alanine carboxypeptidase 621133..621849 Streptococcus pneumoniae 70585 7684053 YP_002739974.1 CDS rplK NC_012468.1 622158 622583 D binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 622158..622583 Streptococcus pneumoniae 70585 7683742 YP_002739975.1 CDS rplA NC_012468.1 622791 623480 D in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 622791..623480 Streptococcus pneumoniae 70585 7683390 YP_002739976.1 CDS SP70585_0693 NC_012468.1 624126 624317 R chlorohydrolase complement(624126..624317) Streptococcus pneumoniae 70585 7684296 YP_002739977.1 CDS SP70585_0694 NC_012468.1 624475 624693 D hypothetical protein 624475..624693 Streptococcus pneumoniae 70585 7683863 YP_002739978.1 CDS SP70585_0695 NC_012468.1 625572 625703 R identified by glimmer; putative; hypothetical protein complement(625572..625703) Streptococcus pneumoniae 70585 7683003 YP_002739979.1 CDS SP70585_0696 NC_012468.1 625737 626729 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 625737..626729 Streptococcus pneumoniae 70585 7684453 YP_002739980.1 CDS SP70585_0697 NC_012468.1 626731 627549 D identified by match to protein family HMM PF06182; membrane protein 626731..627549 Streptococcus pneumoniae 70585 7683849 YP_002739981.1 CDS SP70585_0698 NC_012468.1 627551 628336 D identified by match to protein family HMM PF06182; ABC transporter permease 627551..628336 Streptococcus pneumoniae 70585 7683286 YP_002739982.1 CDS SP70585_0701 NC_012468.1 629110 629334 R hypothetical protein complement(629110..629334) Streptococcus pneumoniae 70585 7684664 YP_002739983.1 CDS SP70585_0702 NC_012468.1 629567 636001 D identified by match to protein family HMM PF00082; match to protein family HMM PF00746; match to protein family HMM PF02225; match to protein family HMM PF05922; match to protein family HMM PF06280; match to protein family HMM TIGR01167; serine protease 629567..636001 Streptococcus pneumoniae 70585 7683728 YP_002739984.1 CDS SP70585_0703 NC_012468.1 636628 637104 D identified by match to protein family HMM PF00359; phosphotransferase system sugar-specific EII component 636628..637104 Streptococcus pneumoniae 70585 7685140 YP_002739985.1 CDS SP70585_0704 NC_012468.1 637142 637447 D PTS system, galactose-specific IIB component 637142..637447 Streptococcus pneumoniae 70585 7685197 YP_002739986.1 CDS SP70585_0705 NC_012468.1 637495 638970 D identified by match to protein family HMM PF03611; phosphotransferase system sugar-specific EII component 637495..638970 Streptococcus pneumoniae 70585 7683685 YP_002739987.1 CDS SP70585_0706 NC_012468.1 638996 639142 D chlorohydrolase 638996..639142 Streptococcus pneumoniae 70585 7684860 YP_002739988.1 CDS SP70585_0707 NC_012468.1 639230 645916 D identified by match to protein family HMM PF00703; match to protein family HMM PF00746; match to protein family HMM PF02836; match to protein family HMM PF02837; match to protein family HMM PF04650; match to protein family HMM PF07501; match to protein family HMM PF07532; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; beta-galactosidase 639230..645916 Streptococcus pneumoniae 70585 7683463 YP_002739989.1 CDS SP70585_0708 NC_012468.1 646164 646787 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase complement(646164..646787) Streptococcus pneumoniae 70585 7684417 YP_002739990.1 CDS SP70585_0709 NC_012468.1 646775 647020 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase complement(646775..647020) Streptococcus pneumoniae 70585 7685158 YP_002739991.1 CDS SP70585_0710 NC_012468.1 647230 647589 R integral membrane protein complement(647230..647589) Streptococcus pneumoniae 70585 7684957 YP_002739992.1 CDS SP70585_0713 NC_012468.1 648631 649188 D identified by match to protein family HMM PF06962; SAM-dependent methyltransferase 648631..649188 Streptococcus pneumoniae 70585 7684556 YP_002739993.1 CDS SP70585_0714 NC_012468.1 649181 649435 D hypothetical protein 649181..649435 Streptococcus pneumoniae 70585 7684740 YP_002739994.1 CDS SP70585_0715 NC_012468.1 649447 651501 D identified by match to protein family HMM PF00999; Na+/H+ antiporter 649447..651501 Streptococcus pneumoniae 70585 7684875 YP_002739995.1 CDS SP70585_0716 NC_012468.1 651680 652540 D identified by match to protein family HMM PF03631; ribonuclease BN 651680..652540 Streptococcus pneumoniae 70585 7683194 YP_002739996.1 CDS SP70585_0717 NC_012468.1 652751 653461 D identified by match to protein family HMM PF02683; cytoChrome c-type biogenesis protein 652751..653461 Streptococcus pneumoniae 70585 7684662 YP_002739997.1 CDS SP70585_0718 NC_012468.1 653481 654047 D identified by match to protein family HMM PF00578; match to protein family HMM PF08534; thioredoxin family protein 653481..654047 Streptococcus pneumoniae 70585 7685147 YP_002739998.1 CDS SP70585_0719 NC_012468.1 654058 655170 D identified by match to protein family HMM PF01625; match to protein family HMM PF01641; match to protein family HMM TIGR00357; match to protein family HMM TIGR00401; peptide methionine sulfoxide reductase MsrA/msrB 654058..655170 Streptococcus pneumoniae 70585 7683266 YP_002739999.1 CDS SP70585_0720 NC_012468.1 655438 656175 D identified by match to protein family HMM PF00072; match to protein family HMM PF00165; response regulator 655438..656175 Streptococcus pneumoniae 70585 7682905 YP_002740000.1 CDS SP70585_0721 NC_012468.1 656172 657863 D identified by match to protein family HMM PF00672; match to protein family HMM PF02518; match to protein family HMM PF02743; match to protein family HMM PF06580; histidine kinase 656172..657863 Streptococcus pneumoniae 70585 7684727 YP_002740001.1 CDS SP70585_0722 NC_012468.1 657979 658542 D identified by match to protein family HMM PF04260; match to protein family HMM TIGR01440; hypothetical protein 657979..658542 Streptococcus pneumoniae 70585 7683017 YP_002740002.1 CDS zmpB NC_012468.1 658564 664251 D identified by match to protein family HMM PF00746; match to protein family HMM PF05342; match to protein family HMM PF07501; match to protein family HMM PF07580; match to protein family HMM TIGR01167; zinc metalloprotease ZmpB 658564..664251 Streptococcus pneumoniae 70585 7684951 YP_002740003.1 CDS SP70585_0724 NC_012468.1 664320 666041 D identified by match to protein family HMM PF00425; match to protein family HMM TIGR00553; chorismate binding enzyme 664320..666041 Streptococcus pneumoniae 70585 7683508 YP_002740004.1 CDS SP70585_0725 NC_012468.1 666042 666659 D hypothetical protein 666042..666659 Streptococcus pneumoniae 70585 7683652 YP_002740005.1 CDS SP70585_0726 NC_012468.1 666709 667707 D identified by match to protein family HMM PF01473; match to protein family HMM PF05901; match to protein family HMM PF07553; hypothetical protein 666709..667707 Streptococcus pneumoniae 70585 7683229 YP_002740006.1 CDS SP70585_0727 NC_012468.1 667834 668793 D identified by match to protein family HMM PF00480; match to protein family HMM TIGR00744; glucokinase (Glucose kinase) 667834..668793 Streptococcus pneumoniae 70585 7683075 YP_002740007.1 CDS thyA NC_012468.1 668890 669729 D ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase 668890..669729 Streptococcus pneumoniae 70585 7684630 YP_002740008.1 CDS SP70585_0729 NC_012468.1 669777 669947 R hypothetical protein complement(669777..669947) Streptococcus pneumoniae 70585 7684069 YP_002740009.1 CDS miaA NC_012468.1 670044 670952 D IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 670044..670952 Streptococcus pneumoniae 70585 7683892 YP_002740010.1 CDS hflX NC_012468.1 670945 672183 D identified by match to protein family HMM PF01926; match to protein family HMM TIGR00231; match to protein family HMM TIGR03156; GTP-binding proten HflX 670945..672183 Streptococcus pneumoniae 70585 7684528 YP_002740011.1 CDS SP70585_0732 NC_012468.1 672176 672799 D cystathionine beta-lyase 672176..672799 Streptococcus pneumoniae 70585 7683004 YP_002740012.1 CDS rnz NC_012468.1 672814 673743 D member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions; ribonuclease Z 672814..673743 Streptococcus pneumoniae 70585 7684277 YP_002740013.1 CDS SP70585_0734 NC_012468.1 673764 674519 D identified by match to protein family HMM PF00106; match to protein family HMM PF08659; oxidoreductase 673764..674519 Streptococcus pneumoniae 70585 7683369 YP_002740014.1 CDS SP70585_0735 NC_012468.1 674573 675541 R identified by match to protein family HMM PF00126; regulatory function on capsule expression complement(674573..675541) Streptococcus pneumoniae 70585 7684082 YP_002740015.1 CDS SP70585_0736 NC_012468.1 675545 675814 D identified by match to protein family HMM PF06014; hypothetical protein 675545..675814 Streptococcus pneumoniae 70585 7683872 YP_002740016.1 CDS SP70585_0737 NC_012468.1 675814 676194 D identified by match to protein family HMM PF00581; rhodanese family protein 675814..676194 Streptococcus pneumoniae 70585 7683980 YP_002740017.1 CDS SP70585_0738 NC_012468.1 676283 676510 D hypothetical protein 676283..676510 Streptococcus pneumoniae 70585 7684160 YP_002740018.1 CDS SP70585_0739 NC_012468.1 676550 677275 R identified by match to protein family HMM PF00849; match to protein family HMM PF01479; match to protein family HMM TIGR00093; ribosomal small subunit pseudouridine synthase A, putative complement(676550..677275) Streptococcus pneumoniae 70585 7683445 YP_002740019.1 CDS typA NC_012468.1 677437 679278 D identified by match to protein family HMM PF00009; match to protein family HMM PF00679; match to protein family HMM PF03144; match to protein family HMM TIGR00231; match to protein family HMM TIGR01394; GTP-binding protein TypA/BipA 677437..679278 Streptococcus pneumoniae 70585 7685156 YP_002740020.1 CDS SP70585_0741 NC_012468.1 679298 679552 D hypothetical protein 679298..679552 Streptococcus pneumoniae 70585 7683689 YP_002740021.1 CDS SP70585_0742 NC_012468.1 679915 680214 D identified by match to protein family HMM TIGR01653; bacteriocin, lactococcin 972 family 679915..680214 Streptococcus pneumoniae 70585 7685034 YP_002740022.1 CDS SP70585_0743 NC_012468.1 680285 682306 D identified by match to protein family HMM PF07242; match to protein family HMM TIGR01654; bacteriocin-associated integral membrane protein 680285..682306 Streptococcus pneumoniae 70585 7685173 YP_002740023.1 CDS SP70585_0744 NC_012468.1 682308 682949 D identified by match to protein family HMM PF00005; Na+ ABC transporter ATP-binding protein 682308..682949 Streptococcus pneumoniae 70585 7684971 YP_002740024.1 CDS murD NC_012468.1 683053 684405 D UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 683053..684405 Streptococcus pneumoniae 70585 7683158 YP_002740025.1 CDS murG NC_012468.1 684407 685465 D UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; UDP diphospho-muramoyl pentapeptide beta-N acetylglucosaminyl transferase 684407..685465 Streptococcus pneumoniae 70585 7682881 YP_002740026.1 CDS SP70585_0747 NC_012468.1 685475 686674 D identified by match to protein family HMM PF03799; match to protein family HMM PF08478; cell division protein DivIB 685475..686674 Streptococcus pneumoniae 70585 7684450 YP_002740027.1 CDS pyrF NC_012468.1 686907 687608 D type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 686907..687608 Streptococcus pneumoniae 70585 7683644 YP_002740028.1 CDS pyrE NC_012468.1 687642 688274 D involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 687642..688274 Streptococcus pneumoniae 70585 7684042 YP_002740029.1 CDS SP70585_0750 NC_012468.1 688735 688857 D identified by glimmer; putative; hypothetical protein 688735..688857 Streptococcus pneumoniae 70585 7684230 YP_002740030.1 CDS SP70585_0751 NC_012468.1 688953 689717 D hypothetical protein 688953..689717 Streptococcus pneumoniae 70585 7684159 YP_002740031.1 CDS SP70585_0752 NC_012468.1 689717 690469 D lipoprotein, putative 689717..690469 Streptococcus pneumoniae 70585 7682895 YP_002740032.1 CDS SP70585_0753 NC_012468.1 690473 691177 D hypothetical protein 690473..691177 Streptococcus pneumoniae 70585 7683517 YP_002740033.1 CDS SP70585_0754 NC_012468.1 691174 691821 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 691174..691821 Streptococcus pneumoniae 70585 7683454 YP_002740034.1 CDS SP70585_0755 NC_012468.1 691901 692761 R identified by match to protein family HMM PF00497; ABC-type amino acid transport/signal transduction system, periplasmic component/domain protein complement(691901..692761) Streptococcus pneumoniae 70585 7683337 YP_002740035.1 CDS SP70585_0757 NC_012468.1 693531 694208 R identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; glutamine ABC transporter permease complement(693531..694208) Streptococcus pneumoniae 70585 7684357 YP_002740036.1 CDS SP70585_0758 NC_012468.1 694168 694848 R identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; glutamine ABC transporter permease complement(694168..694848) Streptococcus pneumoniae 70585 7683768 YP_002740037.1 CDS SP70585_0759 NC_012468.1 695064 695210 D hypothetical protein 695064..695210 Streptococcus pneumoniae 70585 7683995 YP_002740038.1 CDS lysS NC_012468.1 695338 696828 D class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 695338..696828 Streptococcus pneumoniae 70585 7683135 YP_002740039.1 CDS lctO NC_012468.1 697452 698588 D identified by match to protein family HMM PF01070; match to protein family HMM TIGR02708; L-lactate oxidase 697452..698588 Streptococcus pneumoniae 70585 7684894 YP_002740040.1 CDS SP70585_0763 NC_012468.1 699143 699811 D identified by match to protein family HMM PF03070; tena/thi-4 family 699143..699811 Streptococcus pneumoniae 70585 7684199 YP_002740041.1 CDS SP70585_0762 NC_012468.1 699808 700035 R hypothetical protein complement(699808..700035) Streptococcus pneumoniae 70585 7683473 YP_002740042.1 CDS thiM NC_012468.1 700138 700920 D catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP; hydroxyethylthiazole kinase 700138..700920 Streptococcus pneumoniae 70585 7684943 YP_002740043.1 CDS thiE1 NC_012468.1 700922 701551 D identified by match to protein family HMM PF02581; match to protein family HMM TIGR00693; thiamine-phosphate pyrophosphorylase 700922..701551 Streptococcus pneumoniae 70585 7683409 YP_002740044.1 CDS SP70585_0766 NC_012468.1 702109 702669 D cobalt ABC transporter permease 702109..702669 Streptococcus pneumoniae 70585 7685068 YP_002740045.1 CDS SP70585_0767 NC_012468.1 702670 704055 D identified by match to protein family HMM PF00005; cobalt ABC transporter ATP-binding protein 702670..704055 Streptococcus pneumoniae 70585 7683745 YP_002740046.1 CDS SP70585_0768 NC_012468.1 704057 704707 D hypothetical protein 704057..704707 Streptococcus pneumoniae 70585 7683418 YP_002740047.1 CDS SP70585_0769 NC_012468.1 704718 705410 D identified by match to protein family HMM PF03070; tena/thi-4 family 704718..705410 Streptococcus pneumoniae 70585 7683709 YP_002740048.1 CDS thiW NC_012468.1 705415 705939 D identified by match to protein family HMM TIGR02359; ThiW protein 705415..705939 Streptococcus pneumoniae 70585 7684991 YP_002740049.1 CDS SP70585_0771 NC_012468.1 705939 706742 D identified by match to protein family HMM PF02110; hydroxyethylthiazole kinase 705939..706742 Streptococcus pneumoniae 70585 7683153 YP_002740050.1 CDS thiE NC_012468.1 706735 707367 D Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate; thiamine-phosphate pyrophosphorylase 706735..707367 Streptococcus pneumoniae 70585 7682994 YP_002740051.1 CDS thiD NC_012468.1 707576 708367 R catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase complement(707576..708367) Streptococcus pneumoniae 70585 7683789 YP_002740052.1 CDS SP70585_0774 NC_012468.1 708733 709128 D identified by match to protein family HMM PF03965; match to protein family HMM TIGR02698; copper transport repressor, CopY/TcrY family 708733..709128 Streptococcus pneumoniae 70585 7685033 YP_002740053.1 CDS SP70585_0775 NC_012468.1 709139 709510 D hypothetical protein 709139..709510 Streptococcus pneumoniae 70585 7684968 YP_002740054.1 CDS SP70585_0776 NC_012468.1 709520 711763 D identified by match to protein family HMM PF00122; match to protein family HMM PF00702; match to protein family HMM PF08282; match to protein family HMM TIGR01494; match to protein family HMM TIGR01511; match to protein family HMM TIGR01525; copper-translocating P-type ATPase 709520..711763 Streptococcus pneumoniae 70585 7685112 YP_002740055.1 CDS spxB NC_012468.1 711970 713745 D identified by match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; match to protein family HMM TIGR02720; pyruvate oxidase 711970..713745 Streptococcus pneumoniae 70585 7683145 YP_002740056.1 CDS SP70585_0778 NC_012468.1 713856 714203 D identified by match to protein family HMM PF00903; glyoxalase family protein 713856..714203 Streptococcus pneumoniae 70585 7683575 YP_002740057.1 CDS SP70585_0779 NC_012468.1 714320 714829 R transposase family protein complement(714320..714829) Streptococcus pneumoniae 70585 7683303 YP_002740058.1 CDS SP70585_0780 NC_012468.1 714861 715265 R transposase complement(714861..715265) Streptococcus pneumoniae 70585 7683141 YP_002740059.1 CDS SP70585_0781 NC_012468.1 715537 715833 D 6-phospho-beta-glucosidase AscB 715537..715833 Streptococcus pneumoniae 70585 7684849 YP_002740060.1 CDS manA NC_012468.1 715954 716898 D identified by match to protein family HMM PF01238; match to protein family HMM TIGR00218; mannose-6-phosphate isomerase, class I 715954..716898 Streptococcus pneumoniae 70585 7683193 YP_002740061.1 CDS SP70585_0786 NC_012468.1 719284 719700 R identified by match to protein family HMM PF00293; MutT/nudix family protein complement(719284..719700) Streptococcus pneumoniae 70585 7683315 YP_002740062.1 CDS SP70585_0787 NC_012468.1 719759 720934 R identified by match to protein family HMM PF03486; match to protein family HMM TIGR00275; hypothetical protein complement(719759..720934) Streptococcus pneumoniae 70585 7683837 YP_002740063.1 CDS SP70585_0788 NC_012468.1 720993 721838 R identified by match to protein family HMM PF02645; hypothetical protein complement(720993..721838) Streptococcus pneumoniae 70585 7683349 YP_002740064.1 CDS SP70585_0789 NC_012468.1 721963 722520 D identified by match to protein family HMM PF00440; TetR family transcriptional regulator 721963..722520 Streptococcus pneumoniae 70585 7683209 YP_002740065.1 CDS SP70585_0790 NC_012468.1 722539 723006 D identified by match to protein family HMM PF00383; ComE operon protein 2 722539..723006 Streptococcus pneumoniae 70585 7683605 YP_002740066.1 CDS upp NC_012468.1 723074 723724 D Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 723074..723724 Streptococcus pneumoniae 70585 7683147 YP_002740067.1 CDS clpP NC_012468.1 723899 724489 D hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 723899..724489 Streptococcus pneumoniae 70585 7685058 YP_002740068.1 CDS SP70585_0793 NC_012468.1 724568 724816 D hypothetical protein 724568..724816 Streptococcus pneumoniae 70585 7684713 YP_002740069.1 CDS SP70585_0794 NC_012468.1 724917 726077 D identified by match to protein family HMM PF01094; ABC transporter substrate-binding protein - branched chain amino acid transport 724917..726077 Streptococcus pneumoniae 70585 7683778 YP_002740070.1 CDS SP70585_0795 NC_012468.1 726345 727214 D identified by match to protein family HMM PF02653; high-affinity branched-chain amino acid transport system permeaseprotein LivH (LIV-I protein H) 726345..727214 Streptococcus pneumoniae 70585 7683414 YP_002740071.1 CDS SP70585_0796 NC_012468.1 727218 728174 D identified by match to protein family HMM PF02653; branched-chain amino acid ABC transporter permease 727218..728174 Streptococcus pneumoniae 70585 7683710 YP_002740072.1 CDS SP70585_0797 NC_012468.1 728174 728938 D identified by match to protein family HMM PF00005; high-affinity branched-chain amino acid transport ATP-binding proteinlivG (LIV-I protein G) 728174..728938 Streptococcus pneumoniae 70585 7682997 YP_002740073.1 CDS SP70585_0798 NC_012468.1 728938 729648 D identified by match to protein family HMM PF00005; high-affinity branched-chain amino acid transport ATP-binding proteinlivF (LIV-I protein F) 728938..729648 Streptococcus pneumoniae 70585 7683164 YP_002740074.1 CDS SP70585_0799 NC_012468.1 730007 730663 D identified by match to protein family HMM PF00571; AcuB family protein 730007..730663 Streptococcus pneumoniae 70585 7685086 YP_002740075.1 CDS prfB NC_012468.1 730876 731865 D recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 730876..731865 Streptococcus pneumoniae 70585 7684370 YP_002740076.1 CDS ftsE NC_012468.1 731883 732575 D identified by match to protein family HMM PF00005; match to protein family HMM TIGR02673; cell division ATP-binding protein FtsE 731883..732575 Streptococcus pneumoniae 70585 7683861 YP_002740077.1 CDS SP70585_0802 NC_012468.1 732568 733494 D identified by match to protein family HMM PF02687; cell division ABC transporter permease FtsX 732568..733494 Streptococcus pneumoniae 70585 7683127 YP_002740078.1 CDS SP70585_0803 NC_012468.1 733780 735960 D identified by match to protein family HMM PF00358; match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826; match to protein family HMM TIGR00830; match to protein family HMM TIGR02003; pts system, iibc component 733780..735960 Streptococcus pneumoniae 70585 7684400 YP_002740079.1 CDS SP70585_0804 NC_012468.1 736012 736827 D identified by match to protein family HMM PF03372; metal-dependent hydrolase 736012..736827 Streptococcus pneumoniae 70585 7682885 YP_002740080.1 CDS SP70585_0805 NC_012468.1 736967 738310 D identified by match to protein family HMM PF00270; match to protein family HMM PF00271; superfamily II DNA and RNA helicase 736967..738310 Streptococcus pneumoniae 70585 7685088 YP_002740081.1 CDS metK NC_012468.1 738687 739877 D catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 738687..739877 Streptococcus pneumoniae 70585 7684730 YP_002740082.1 CDS SP70585_0807 NC_012468.1 740430 741365 D catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; subclass 1A is a dimer formed by two identical PyrD subunits each containing an FMN group; dihydroorotate dehydrogenase 1A 740430..741365 Streptococcus pneumoniae 70585 7682984 YP_002740083.1 CDS holA NC_012468.1 741399 742436 D required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta 741399..742436 Streptococcus pneumoniae 70585 7683658 YP_002740084.1 CDS SP70585_0809 NC_012468.1 742609 743214 D identified by match to protein family HMM PF00081; match to protein family HMM PF02777; superoxide dismutase [Mn] (General stress protein 24)(GSP24) 742609..743214 Streptococcus pneumoniae 70585 7682891 YP_002740085.1 CDS SP70585_0810 NC_012468.1 743370 743900 D identified by match to protein family HMM PF06265; transcriptional regulator 743370..743900 Streptococcus pneumoniae 70585 7683274 YP_002740086.1 CDS SP70585_0811 NC_012468.1 743921 745006 D 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance; ribosomal RNA large subunit methyltransferase N 743921..745006 Streptococcus pneumoniae 70585 7684562 YP_002740087.1 CDS SP70585_0812 NC_012468.1 745006 745488 D identified by match to protein family HMM PF04892; VanZ family protein 745006..745488 Streptococcus pneumoniae 70585 7685002 YP_002740088.1 CDS SP70585_0813 NC_012468.1 745490 747031 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 745490..747031 Streptococcus pneumoniae 70585 7683807 YP_002740089.1 CDS SP70585_0814 NC_012468.1 747088 747891 R identified by match to protein family HMM PF00160; peptidyl-prolyl cis-trans isomerase, cyclophilin-type complement(747088..747891) Streptococcus pneumoniae 70585 7683410 YP_002740090.1 CDS SP70585_0815 NC_012468.1 747974 748186 R hypothetical protein complement(747974..748186) Streptococcus pneumoniae 70585 7683160 YP_002740091.1 CDS SP70585_0816 NC_012468.1 748665 748874 R hypothetical protein complement(748665..748874) Streptococcus pneumoniae 70585 7683600 YP_002740092.1 CDS rpsP NC_012468.1 749044 749316 D binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 749044..749316 Streptococcus pneumoniae 70585 7685192 YP_002740093.1 CDS SP70585_0818 NC_012468.1 749336 749575 D hypothetical protein 749336..749575 Streptococcus pneumoniae 70585 7685123 YP_002740094.1 CDS SP70585_0819 NC_012468.1 750152 750940 D identified by match to protein family HMM PF00561; hydrolase, alpha/beta fold family, putative 750152..750940 Streptococcus pneumoniae 70585 7684844 YP_002740095.1 CDS rimM NC_012468.1 750971 751489 D Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 750971..751489 Streptococcus pneumoniae 70585 7685138 YP_002740096.1 CDS trmD NC_012468.1 751479 752198 D methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 751479..752198 Streptococcus pneumoniae 70585 7683836 YP_002740097.1 CDS SP70585_0822 NC_012468.1 752210 752548 D identified by match to protein family HMM PF03477; oxygen-sensitive ribonucleoside-triphosphate reductase 752210..752548 Streptococcus pneumoniae 70585 7684361 YP_002740098.1 CDS SP70585_0823 NC_012468.1 752579 752899 R hypothetical protein complement(752579..752899) Streptococcus pneumoniae 70585 7683168 YP_002740099.1 CDS SP70585_0825 NC_012468.1 752997 753212 D hypothetical protein 752997..753212 Streptococcus pneumoniae 70585 7683470 YP_002740100.1 CDS SP70585_0824 NC_012468.1 753209 753355 R chlorohydrolase complement(753209..753355) Streptococcus pneumoniae 70585 7684251 YP_002740101.1 CDS SP70585_0826 NC_012468.1 753417 753953 R identified by match to protein family HMM PF02632; biotin synthase complement(753417..753953) Streptococcus pneumoniae 70585 7684354 YP_002740102.1 CDS gor NC_012468.1 754150 755496 R catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase complement(754150..755496) Streptococcus pneumoniae 70585 7683056 YP_002740103.1 CDS SP70585_0828 NC_012468.1 755761 756960 D identified by match to protein family HMM TIGR01730; membrane-fusion protein 755761..756960 Streptococcus pneumoniae 70585 7683102 YP_002740104.1 CDS SP70585_0829 NC_012468.1 756944 757645 D identified by match to protein family HMM PF00005; macrolide export ATP-binding/permease MacB 756944..757645 Streptococcus pneumoniae 70585 7683825 YP_002740105.1 CDS SP70585_0830 NC_012468.1 757647 758906 D identified by match to protein family HMM PF02687; antimicrobial peptide ABC transporter permease 757647..758906 Streptococcus pneumoniae 70585 7683336 YP_002740106.1 CDS metG1 NC_012468.1 759030 761027 D methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 759030..761027 Streptococcus pneumoniae 70585 7684253 YP_002740107.1 CDS SP70585_0832 NC_012468.1 761077 761358 D chlorohydrolase 761077..761358 Streptococcus pneumoniae 70585 7683396 YP_002740108.1 CDS SP70585_0833 NC_012468.1 761448 761768 D identified by match to protein family HMM PF03551; transcriptional regulator, PadR family 761448..761768 Streptococcus pneumoniae 70585 7683947 YP_002740109.1 CDS SP70585_0834 NC_012468.1 761772 762587 D hypothetical protein 761772..762587 Streptococcus pneumoniae 70585 7684233 YP_002740110.1 CDS SP70585_0835 NC_012468.1 762662 763588 D identified by match to protein family HMM PF00248; oxidoreductase, aldo/keto reductase family 762662..763588 Streptococcus pneumoniae 70585 7683275 YP_002740111.1 CDS SP70585_0836 NC_012468.1 763684 763920 D hypothetical protein 763684..763920 Streptococcus pneumoniae 70585 7684714 YP_002740112.1 CDS fabG NC_012468.1 763913 764611 D Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 763913..764611 Streptococcus pneumoniae 70585 7683510 YP_002740113.1 CDS SP70585_0838 NC_012468.1 764622 765101 D identified by match to protein family HMM PF00293; MutT/nudix family protein 764622..765101 Streptococcus pneumoniae 70585 7684518 YP_002740114.1 CDS SP70585_0839 NC_012468.1 765109 765837 D identified by match to protein family HMM PF00583; acetyltransferase, gnat family 765109..765837 Streptococcus pneumoniae 70585 7683716 YP_002740115.1 CDS SP70585_0840 NC_012468.1 765879 766526 D PEP-utilizing enzyme family protein 765879..766526 Streptococcus pneumoniae 70585 7685001 YP_002740116.1 CDS SP70585_0841 NC_012468.1 766501 766941 D identified by match to protein family HMM PF06171; hypothetical protein 766501..766941 Streptococcus pneumoniae 70585 7684226 YP_002740117.1 CDS SP70585_0842 NC_012468.1 767064 769610 D identified by match to protein family HMM PF01433; aminopeptidase N 767064..769610 Streptococcus pneumoniae 70585 7683065 YP_002740118.1 CDS SP70585_0843 NC_012468.1 769719 770393 D identified by match to protein family HMM PF00072; match to protein family HMM PF00486; transcriptional regulatory protein CiaR 769719..770393 Streptococcus pneumoniae 70585 7684489 YP_002740119.1 CDS SP70585_0844 NC_012468.1 770383 771717 D identified by match to protein family HMM PF00512; match to protein family HMM PF02518; sensor protein CiaH 770383..771717 Streptococcus pneumoniae 70585 7683381 YP_002740120.1 CDS SP70585_0845 NC_012468.1 771751 772038 R hypothetical protein complement(771751..772038) Streptococcus pneumoniae 70585 7685157 YP_002740121.1 CDS SP70585_0846 NC_012468.1 772178 773107 D identified by match to protein family HMM PF01136; protease 772178..773107 Streptococcus pneumoniae 70585 7684852 YP_002740122.1 CDS SP70585_0847 NC_012468.1 773307 775757 D unwinds DNA; bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon 773307..775757 Streptococcus pneumoniae 70585 7683022 YP_002740123.1 CDS SP70585_0848 NC_012468.1 775767 777017 D identified by match to protein family HMM PF01098; RodA 775767..777017 Streptococcus pneumoniae 70585 7683162 YP_002740124.1 CDS SP70585_0849 NC_012468.1 777028 777582 D identified by match to protein family HMM PF01965; match to protein family HMM TIGR01383; 4-methyl-5(b-hydroxyethyl)-thiazole monophosphate biosynthesis protein 777028..777582 Streptococcus pneumoniae 70585 7683576 YP_002740125.1 CDS SP70585_0850 NC_012468.1 777667 778230 D identified by match to protein family HMM PF00702; match to protein family HMM TIGR01549; phosphoglycolate phosphatase 777667..778230 Streptococcus pneumoniae 70585 7684492 YP_002740126.1 CDS gyrB NC_012468.1 778245 780191 D negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 778245..780191 Streptococcus pneumoniae 70585 7684404 YP_002740127.1 CDS ezrA NC_012468.1 780273 782000 D acts to negatively regulates ftsZ ring formation by modulating the frequency and position of the ftsZ ring formation; septation ring formation regulator EzrA 780273..782000 Streptococcus pneumoniae 70585 7684907 YP_002740128.1 CDS SP70585_0853 NC_012468.1 782729 782944 R identified by match to protein family HMM PF05717; IS66 family element, Orf2 complement(782729..782944) Streptococcus pneumoniae 70585 7683227 YP_002740129.1 CDS SP70585_0854 NC_012468.1 783313 783612 R identified by match to protein family HMM PF08860; hypothetical protein complement(783313..783612) Streptococcus pneumoniae 70585 7683525 YP_002740130.1 CDS SP70585_0855 NC_012468.1 783777 784232 R identified by match to protein family HMM PF00293; MutT/nudix family protein complement(783777..784232) Streptococcus pneumoniae 70585 7683595 YP_002740131.1 CDS SP70585_0856 NC_012468.1 784309 784707 D an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01710; Spn1, transposase Orf1 784309..784707 Streptococcus pneumoniae 70585 7683196 YP_002740132.1 CDS SP70585_0857 NC_012468.1 784816 784956 D Spn1, transposase Orf2 784816..784956 Streptococcus pneumoniae 70585 7683329 YP_002740133.1 CDS SP70585_0858 NC_012468.1 785466 787724 R identified by match to protein family HMM PF00004; match to protein family HMM PF02151; match to protein family HMM PF07724; match to protein family HMM PF07728; negative regulator of genetic competence ClpC/mecB complement(785466..787724) Streptococcus pneumoniae 70585 7683835 YP_002740134.1 CDS SP70585_0859 NC_012468.1 787953 788183 R identified by match to protein family HMM PF08796; hypothetical protein complement(787953..788183) Streptococcus pneumoniae 70585 7684276 YP_002740135.1 CDS SP70585_0860 NC_012468.1 788374 789057 D identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; amino acid ABC transporter permease 788374..789057 Streptococcus pneumoniae 70585 7685190 YP_002740136.1 CDS SP70585_0861 NC_012468.1 789057 789791 D identified by match to protein family HMM PF00005; glutamine transport ATP-binding protein GlnQ 789057..789791 Streptococcus pneumoniae 70585 7685036 YP_002740137.1 CDS SP70585_0862 NC_012468.1 789924 790802 D catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 789924..790802 Streptococcus pneumoniae 70585 7684440 YP_002740138.1 CDS SP70585_0863 NC_012468.1 790944 791816 D identified by match to protein family HMM PF01256; match to protein family HMM TIGR00196; putative YjeF homolog, C-terminus 790944..791816 Streptococcus pneumoniae 70585 7682972 YP_002740139.1 CDS rpiA NC_012468.1 792098 792781 D Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A 792098..792781 Streptococcus pneumoniae 70585 7683787 YP_002740140.1 CDS deoB NC_012468.1 792795 794006 D catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose; phosphopentomutase 792795..794006 Streptococcus pneumoniae 70585 7683116 YP_002740141.1 CDS SP70585_0866 NC_012468.1 794008 794418 D identified by glimmer; putative; hypothetical protein 794008..794418 Streptococcus pneumoniae 70585 7683878 YP_002740142.1 CDS SP70585_0867 NC_012468.1 794396 794536 D identified by glimmer; putative; hypothetical protein 794396..794536 Streptococcus pneumoniae 70585 7682910 YP_002740143.1 CDS SP70585_0868 NC_012468.1 794552 795361 D catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation; purine nucleoside phosphorylase 794552..795361 Streptococcus pneumoniae 70585 7684686 YP_002740144.1 CDS SP70585_0870 NC_012468.1 796068 796817 D identified by glimmer; putative; hypothetical protein 796068..796817 Streptococcus pneumoniae 70585 7684420 YP_002740145.1 CDS SP70585_0871 NC_012468.1 796842 797354 D hemolysin-related protein 796842..797354 Streptococcus pneumoniae 70585 7684048 YP_002740146.1 CDS deoD NC_012468.1 798012 798722 D catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase 798012..798722 Streptococcus pneumoniae 70585 7684937 YP_002740147.1 CDS SP70585_0873 NC_012468.1 798745 799269 R topology modulation protein complement(798745..799269) Streptococcus pneumoniae 70585 7683107 YP_002740148.1 CDS rpsT NC_012468.1 799322 799558 R binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 complement(799322..799558) Streptococcus pneumoniae 70585 7684668 YP_002740149.1 CDS coaA NC_012468.1 799626 800546 R catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase complement(799626..800546) Streptococcus pneumoniae 70585 7683703 YP_002740150.1 CDS SP70585_0876 NC_012468.1 800932 801090 D identified by glimmer; putative; hypothetical protein 800932..801090 Streptococcus pneumoniae 70585 7683822 YP_002740151.1 CDS SP70585_0877 NC_012468.1 801319 801900 D identified by match to protein family HMM PF05175; methyltransferase small domain superfamily 801319..801900 Streptococcus pneumoniae 70585 7683393 YP_002740152.1 CDS SP70585_0878 NC_012468.1 801897 803174 D Catalyzes the reversible phosphorolysis of pyrimidines in the nucleotide synthesis salvage pathway; pyrimidine-nucleoside phosphorylase 801897..803174 Streptococcus pneumoniae 70585 7683750 YP_002740153.1 CDS deoC NC_012468.1 803192 803854 D catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 803192..803854 Streptococcus pneumoniae 70585 7683151 YP_002740154.1 CDS cdd1 NC_012468.1 803841 804230 D Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 803841..804230 Streptococcus pneumoniae 70585 7685056 YP_002740155.1 CDS SP70585_0881 NC_012468.1 804321 805373 D identified by match to protein family HMM PF02608; lipoprotein 804321..805373 Streptococcus pneumoniae 70585 7684010 YP_002740156.1 CDS SP70585_0882 NC_012468.1 805517 807052 D identified by match to protein family HMM PF00005; ribose import ATP-binding protein RbsA 805517..807052 Streptococcus pneumoniae 70585 7684216 YP_002740157.1 CDS SP70585_0883 NC_012468.1 807045 808103 D identified by match to protein family HMM PF02653; ribose/galactose ABC transporter permease 807045..808103 Streptococcus pneumoniae 70585 7684826 YP_002740158.1 CDS SP70585_0884 NC_012468.1 808106 809062 D identified by match to protein family HMM PF02653; ribose/galactose ABC transporter permease 808106..809062 Streptococcus pneumoniae 70585 7684561 YP_002740159.1 CDS SP70585_0885 NC_012468.1 809147 809359 D an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase 809147..809359 Streptococcus pneumoniae 70585 7682936 YP_002740160.1 CDS SP70585_0886 NC_012468.1 809585 810418 D identified by match to protein family HMM PF00665; integrase core domain protein 809585..810418 Streptococcus pneumoniae 70585 7683295 YP_002740161.1 CDS SP70585_0887 NC_012468.1 810461 811102 R involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX; putative glycerol-3-phosphate acyltransferase PlsY complement(810461..811102) Streptococcus pneumoniae 70585 7683450 YP_002740162.1 CDS parE NC_012468.1 811238 813181 D decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B 811238..813181 Streptococcus pneumoniae 70585 7683530 YP_002740163.1 CDS SP70585_0889 NC_012468.1 813302 813427 D identified by glimmer; putative; hypothetical protein 813302..813427 Streptococcus pneumoniae 70585 7683064 YP_002740164.1 CDS parC NC_012468.1 813592 816072 D decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A 813592..816072 Streptococcus pneumoniae 70585 7684635 YP_002740165.1 CDS ilvE NC_012468.1 816204 817226 D catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 816204..817226 Streptococcus pneumoniae 70585 7684690 YP_002740166.1 CDS SP70585_0892 NC_012468.1 817282 817986 D hypothetical protein 817282..817986 Streptococcus pneumoniae 70585 7684379 YP_002740167.1 CDS SP70585_0893 NC_012468.1 818051 818740 D identified by match to protein family HMM PF06149; permease 818051..818740 Streptococcus pneumoniae 70585 7685124 YP_002740168.1 CDS SP70585_0894 NC_012468.1 818737 819660 D identified by match to protein family HMM PF06166; permease 818737..819660 Streptococcus pneumoniae 70585 7684803 YP_002740169.1 CDS pcp NC_012468.1 819675 820319 D catalyzes the removal of 5-oxoproline from various penultimate amino acid residues except L-proline; pyrrolidone-carboxylate peptidase 819675..820319 Streptococcus pneumoniae 70585 7683519 YP_002740170.1 CDS SP70585_0896 NC_012468.1 820487 820717 D hypothetical protein 820487..820717 Streptococcus pneumoniae 70585 7683687 YP_002740171.1 CDS rpsA NC_012468.1 821090 822292 D in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 821090..822292 Streptococcus pneumoniae 70585 7683915 YP_002740172.1 CDS SP70585_0900 NC_012468.1 822376 822894 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase complement(822376..822894) Streptococcus pneumoniae 70585 7684734 YP_002740173.1 CDS SP70585_0901 NC_012468.1 823175 823693 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase complement(823175..823693) Streptococcus pneumoniae 70585 7684680 YP_002740174.1 CDS SP70585_0902 NC_012468.1 823886 824383 D GAF domain-containing protein 823886..824383 Streptococcus pneumoniae 70585 7682918 YP_002740175.1 CDS SP70585_0903 NC_012468.1 824383 826038 D catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 824383..826038 Streptococcus pneumoniae 70585 7684798 YP_002740176.1 CDS SP70585_0904 NC_012468.1 826066 826260 D hypothetical protein 826066..826260 Streptococcus pneumoniae 70585 7684901 YP_002740177.1 CDS sufC NC_012468.1 826410 827180 D identified by match to protein family HMM PF00005; match to protein family HMM TIGR01978; FeS assembly ATPase SufC 826410..827180 Streptococcus pneumoniae 70585 7683416 YP_002740178.1 CDS sufD NC_012468.1 827208 828470 D identified by match to protein family HMM PF01458; match to protein family HMM TIGR01981; FeS assembly protein SufD 827208..828470 Streptococcus pneumoniae 70585 7684002 YP_002740179.1 CDS SP70585_0907 NC_012468.1 828481 829707 D identified by match to protein family HMM PF00266; match to protein family HMM PF01212; match to protein family HMM TIGR01979; cysteine desulfurase (Selenocysteine lyase) (Selenocysteine reductase) (Selenocysteine beta-lyase) (SCL) 828481..829707 Streptococcus pneumoniae 70585 7684536 YP_002740180.1 CDS SP70585_0908 NC_012468.1 829694 830134 D identified by match to protein family HMM PF01592; match to protein family HMM TIGR01994; SUF system FeS assembly protein, NifU family 829694..830134 Streptococcus pneumoniae 70585 7683236 YP_002740181.1 CDS sufB NC_012468.1 830188 831600 D identified by match to protein family HMM PF01458; match to protein family HMM TIGR01980; FeS assembly protein SufB 830188..831600 Streptococcus pneumoniae 70585 7684475 YP_002740182.1 CDS SP70585_0910 NC_012468.1 831799 833040 R identified by match to protein family HMM PF00144; match to protein family HMM PF00768; match to protein family HMM PF07943; D-alanyl-D-alanine carboxypeptidase complement(831799..833040) Streptococcus pneumoniae 70585 7683511 YP_002740183.1 CDS SP70585_0911 NC_012468.1 833221 834252 D identified by match to protein family HMM PF01594; membrane protein 833221..834252 Streptococcus pneumoniae 70585 7683052 YP_002740184.1 CDS SP70585_0913 NC_012468.1 835565 836305 D identified by match to protein family HMM PF00455; match to protein family HMM PF08220; match to protein family HMM PF08279; lactose phosphotransferase system repressor 835565..836305 Streptococcus pneumoniae 70585 7684307 YP_002740185.1 CDS pfkB NC_012468.1 836302 837213 D identified by match to protein family HMM PF00294; match to protein family HMM TIGR03168; 1-phosphofructokinase 836302..837213 Streptococcus pneumoniae 70585 7684641 YP_002740186.1 CDS SP70585_0915 NC_012468.1 837210 839162 D identified by match to protein family HMM PF00359; match to protein family HMM PF02378; match to protein family HMM PF02379; match to protein family HMM TIGR00829; match to protein family HMM TIGR00848; match to protein family HMM TIGR01427; iiabc fructose/xylitol-pts 837210..839162 Streptococcus pneumoniae 70585 7683553 YP_002740187.1 CDS SP70585_0916 NC_012468.1 839326 841551 D identified by match to protein family HMM PF01580; DNA translocase ftsk 839326..841551 Streptococcus pneumoniae 70585 7684219 YP_002740188.1 CDS SP70585_0917 NC_012468.1 841702 842130 R hypothetical protein complement(841702..842130) Streptococcus pneumoniae 70585 7684738 YP_002740189.1 CDS SP70585_0918 NC_012468.1 842268 843410 D identified by match to protein family HMM PF00266; cysteine desulfurase 842268..843410 Streptococcus pneumoniae 70585 7685076 YP_002740190.1 CDS thiI NC_012468.1 843419 844633 D Required for the synthesis of the thiazole moiety; thiamine biosynthesis protein ThiI 843419..844633 Streptococcus pneumoniae 70585 7684537 YP_002740191.1 CDS SP70585_0920 NC_012468.1 844770 845594 D identified by match to protein family HMM PF00756; putative esterase superfamily 844770..845594 Streptococcus pneumoniae 70585 7683035 YP_002740192.1 CDS SP70585_0923 NC_012468.1 846368 847534 D carbamoylphosphate synthase large subunit 846368..847534 Streptococcus pneumoniae 70585 7684434 YP_002740193.1 CDS SP70585_0924 NC_012468.1 848042 849535 D identified by match to protein family HMM PF02384; type I restriction modification enzyme methylase subunit 848042..849535 Streptococcus pneumoniae 70585 7683438 YP_002740194.1 CDS SP70585_0925 NC_012468.1 849548 850669 D identified by match to protein family HMM PF01420; type I restriction-modification system, S subunit, putative 849548..850669 Streptococcus pneumoniae 70585 7683568 YP_002740195.1 CDS SP70585_0926 NC_012468.1 850729 850965 D hypothetical protein 850729..850965 Streptococcus pneumoniae 70585 7684205 YP_002740196.1 CDS SP70585_0927 NC_012468.1 850962 851375 D identified by match to protein family HMM PF05012; match to protein family HMM TIGR01550; prophage maintenance system killer protein 850962..851375 Streptococcus pneumoniae 70585 7685008 YP_002740197.1 CDS SP70585_0928 NC_012468.1 851493 852458 D identified by match to protein family HMM PF00589; match to protein family HMM PF02899; integrase/recombinase, phage integrase family 851493..852458 Streptococcus pneumoniae 70585 7685169 YP_002740198.1 CDS SP70585_0929 NC_012468.1 852492 853535 D identified by match to protein family HMM PF01420; type I restriction-modification system, S subunit 852492..853535 Streptococcus pneumoniae 70585 7684155 YP_002740199.1 CDS SP70585_0930 NC_012468.1 853565 856915 D identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM PF04313; match to protein family HMM PF04851; type I restriction-modification system R subunit 853565..856915 Streptococcus pneumoniae 70585 7684545 YP_002740200.1 CDS SP70585_0931 NC_012468.1 857186 857341 D chlorohydrolase 857186..857341 Streptococcus pneumoniae 70585 7683053 YP_002740201.1 CDS SP70585_0932 NC_012468.1 857457 857927 R identified by match to protein family HMM PF01316; match to protein family HMM PF02863; arginine repressor complement(857457..857927) Streptococcus pneumoniae 70585 7684539 YP_002740202.1 CDS SP70585_0933 NC_012468.1 857944 860217 R catalyzes the removal of N-terminal dipeptides when proline is the penultimate residue; x-prolyl-dipeptidyl aminopeptidase complement(857944..860217) Streptococcus pneumoniae 70585 7683816 YP_002740203.1 CDS dnaE NC_012468.1 860564 863665 D Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. Proposed to be responsible for the synthesis of the lagging strand. In the low GC gram positive bacteria this enzyme is less processive and more error prone than its counterpart in other bacteria.; DNA polymerase III DnaE 860564..863665 Streptococcus pneumoniae 70585 7683512 YP_002740204.1 CDS pfkA NC_012468.1 863747 864754 D catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 863747..864754 Streptococcus pneumoniae 70585 7683272 YP_002740205.1 CDS pyk NC_012468.1 864813 866318 D catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 864813..866318 Streptococcus pneumoniae 70585 7685127 YP_002740206.1 CDS SP70585_0937 NC_012468.1 868123 868995 D lipoprotein, putative 868123..868995 Streptococcus pneumoniae 70585 7684483 YP_002740207.1 CDS SP70585_0938 NC_012468.1 869008 869172 D hypothetical protein 869008..869172 Streptococcus pneumoniae 70585 7683502 YP_002740208.1 CDS SP70585_0939 NC_012468.1 869297 869485 R mobile genetic element complement(869297..869485) Streptococcus pneumoniae 70585 7684346 YP_002740209.1 CDS SP70585_0940 NC_012468.1 869628 869939 D hypothetical protein 869628..869939 Streptococcus pneumoniae 70585 7684241 YP_002740210.1 CDS SP70585_0941 NC_012468.1 869943 870551 D hypothetical protein 869943..870551 Streptococcus pneumoniae 70585 7684256 YP_002740211.1 CDS SP70585_0942 NC_012468.1 870681 871496 R identified by match to protein family HMM PF09323; ABC transporter substrate-binding protein complement(870681..871496) Streptococcus pneumoniae 70585 7683528 YP_002740212.1 CDS SP70585_0943 NC_012468.1 871493 872398 R identified by match to protein family HMM PF03773; membrane protein complement(871493..872398) Streptococcus pneumoniae 70585 7684718 YP_002740213.1 CDS SP70585_0944 NC_012468.1 872399 872530 R hypothetical protein complement(872399..872530) Streptococcus pneumoniae 70585 7683893 YP_002740214.1 CDS SP70585_0945 NC_012468.1 872788 874104 D identified by match to protein family HMM PF08942; capsular polysaccharide biosynthesis protein, putative 872788..874104 Streptococcus pneumoniae 70585 7683243 YP_002740215.1 CDS SP70585_0946 NC_012468.1 874206 876335 D identified by match to protein family HMM PF00575; S1 RNA binding domain protein 874206..876335 Streptococcus pneumoniae 70585 7683083 YP_002740216.1 CDS SP70585_0947 NC_012468.1 876322 876771 D identified by match to protein family HMM PF03926; hypothetical protein 876322..876771 Streptococcus pneumoniae 70585 7683937 YP_002740217.1 CDS SP70585_0948 NC_012468.1 876866 877102 D identified by match to protein family HMM PF04024; PspC domain family 876866..877102 Streptococcus pneumoniae 70585 7685153 YP_002740218.1 CDS SP70585_0949 NC_012468.1 878075 878833 D identified by match to protein family HMM PF00005; bacitracin export ATP-binding protein BceA 878075..878833 Streptococcus pneumoniae 70585 7684250 YP_002740219.1 CDS SP70585_0950 NC_012468.1 878835 880823 D identified by match to protein family HMM PF02687; antimicrobial peptide ABC transporter permease 878835..880823 Streptococcus pneumoniae 70585 7685060 YP_002740220.1 CDS SP70585_0951 NC_012468.1 880865 881455 R identified by match to protein family HMM PF01988; integral membrane protein complement(880865..881455) Streptococcus pneumoniae 70585 7683024 YP_002740221.1 CDS SP70585_0952 NC_012468.1 881700 882530 R transposase complement(881700..882530) Streptococcus pneumoniae 70585 7683620 YP_002740222.1 CDS SP70585_0954 NC_012468.1 883237 884712 D identified by match to protein family HMM PF00266; match to protein family HMM PF01212; match to protein family HMM PF01276; match to protein family HMM PF03711; arginine decarboxylase 883237..884712 Streptococcus pneumoniae 70585 7683718 YP_002740223.1 CDS SP70585_0953 NC_012468.1 884678 885148 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; pilin gene inverting-related protein complement(884678..885148) Streptococcus pneumoniae 70585 7683803 YP_002740224.1 CDS SP70585_0955 NC_012468.1 885271 885393 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase complement(885271..885393) Streptococcus pneumoniae 70585 7684802 YP_002740225.1 CDS SP70585_0956 NC_012468.1 885480 885617 D identified by glimmer; putative; hypothetical protein 885480..885617 Streptococcus pneumoniae 70585 7684081 YP_002740226.1 CDS speE NC_012468.1 885648 886508 D catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase 885648..886508 Streptococcus pneumoniae 70585 7684157 YP_002740227.1 CDS lys NC_012468.1 886505 887764 D identified by match to protein family HMM PF03435; saccharopine dehydrogenase 886505..887764 Streptococcus pneumoniae 70585 7683998 YP_002740228.1 CDS nspC NC_012468.1 887764 888891 D identified by match to protein family HMM PF00278; match to protein family HMM TIGR01047; carboxynorspermidine decarboxylase 887764..888891 Streptococcus pneumoniae 70585 7684341 YP_002740229.1 CDS aguA NC_012468.1 888888 889973 D catalyzes the formation of carbamoylputrescine from agmatine in the arginine decarboxylase pathway of putrescine biosynthesis; agmatine deiminase 888888..889973 Streptococcus pneumoniae 70585 7682943 YP_002740230.1 CDS aguB NC_012468.1 889983 890858 D identified by match to protein family HMM PF00795; match to protein family HMM TIGR03381; N-carbamoylputrescine amidase 889983..890858 Streptococcus pneumoniae 70585 7683014 YP_002740231.1 CDS SP70585_0962 NC_012468.1 891039 891848 R identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; Cof family protein complement(891039..891848) Streptococcus pneumoniae 70585 7684224 YP_002740232.1 CDS SP70585_0963 NC_012468.1 892120 892341 D hypothetical protein 892120..892341 Streptococcus pneumoniae 70585 7684616 YP_002740233.1 CDS SP70585_0964 NC_012468.1 892395 893066 D identified by match to protein family HMM PF02517; caax amino protease family 892395..893066 Streptococcus pneumoniae 70585 7684652 YP_002740234.1 CDS SP70585_0965 NC_012468.1 893118 893315 R hypothetical protein complement(893118..893315) Streptococcus pneumoniae 70585 7683862 YP_002740235.1 CDS SP70585_0966 NC_012468.1 893308 894216 D identified by match to protein family HMM PF00126; match to protein family HMM PF03466; regulatory function on capsule expression in group B streptococci 893308..894216 Streptococcus pneumoniae 70585 7682973 YP_002740236.1 CDS lspA NC_012468.1 894213 894674 D lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 894213..894674 Streptococcus pneumoniae 70585 7683486 YP_002740237.1 CDS rluD NC_012468.1 894664 895551 D identified by match to protein family HMM PF00849; match to protein family HMM PF01479; match to protein family HMM TIGR00005; ribosomal large subunit pseudouridine synthase D 894664..895551 Streptococcus pneumoniae 70585 7683624 YP_002740238.1 CDS SP70585_0969 NC_012468.1 895554 897437 D identified by match to protein family HMM PF00753; match to protein family HMM PF01473; choline binding protein E 895554..897437 Streptococcus pneumoniae 70585 7682894 YP_002740239.1 CDS proB NC_012468.1 897538 898647 D catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 897538..898647 Streptococcus pneumoniae 70585 7683259 YP_002740240.1 CDS proA NC_012468.1 898657 899919 D Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 898657..899919 Streptococcus pneumoniae 70585 7684031 YP_002740241.1 CDS proC NC_012468.1 899923 900720 D identified by match to protein family HMM PF01210; match to protein family HMM PF03446; match to protein family HMM PF03807; match to protein family HMM TIGR00112; pyrroline-5-carboxylate reductase 899923..900720 Streptococcus pneumoniae 70585 7684934 YP_002740242.1 CDS tmk NC_012468.1 900940 901578 D catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 900940..901578 Streptococcus pneumoniae 70585 7683476 YP_002740243.1 CDS SP70585_0974 NC_012468.1 901575 902465 D catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA.; DNA polymerase III subunit delta' 901575..902465 Streptococcus pneumoniae 70585 7683169 YP_002740244.1 CDS SP70585_0975 NC_012468.1 902505 902822 D in Bacillus subtilis this protein is involved in the negative regulation of DNA replication initiation; interacts with DnaN and DnaA; DNA replication intiation control protein YabA 902505..902822 Streptococcus pneumoniae 70585 7683593 YP_002740245.1 CDS SP70585_0976 NC_012468.1 902825 903694 D identified by match to protein family HMM PF00590; match to protein family HMM TIGR00096; hypothetical protein 902825..903694 Streptococcus pneumoniae 70585 7684772 YP_002740246.1 CDS SP70585_0977 NC_012468.1 903921 904439 D identified by match to protein family HMM PF08020; hypothetical protein 903921..904439 Streptococcus pneumoniae 70585 7684548 YP_002740247.1 CDS SP70585_0979 NC_012468.1 904548 905195 D identified by match to protein family HMM PF06970; phage protein 904548..905195 Streptococcus pneumoniae 70585 7684766 YP_002740248.1 CDS trmFO NC_012468.1 906481 907815 D TrmFO; Gid; glucose-inhibited division protein; similar to GidA; the gene from Bacillus subtilis encodes a tRNA-methyltransferase that utilizes folate as the carbon donor and bound flavin as reductant; modifies tRNA at position 54 (uridine) of the T-psi loop to form a C5-methyluridine; tRNA (uracil-5-)-methyltransferase Gid 906481..907815 Streptococcus pneumoniae 70585 7685103 YP_002740249.1 CDS pyrH NC_012468.1 907899 908636 D Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 907899..908636 Streptococcus pneumoniae 70585 7683378 YP_002740250.1 CDS frr NC_012468.1 908645 909202 D Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 908645..909202 Streptococcus pneumoniae 70585 7683642 YP_002740251.1 CDS SP70585_0985 NC_012468.1 909223 910116 D s1 RNA binding domain protein 909223..910116 Streptococcus pneumoniae 70585 7684804 YP_002740252.1 CDS SP70585_0986 NC_012468.1 910125 910340 D identified by match to protein family HMM PF06855; hypothetical protein 910125..910340 Streptococcus pneumoniae 70585 7683783 YP_002740253.1 CDS SP70585_0987 NC_012468.1 910426 911394 D identified by match to protein family HMM PF02562; PhoH family protein 910426..911394 Streptococcus pneumoniae 70585 7684323 YP_002740254.1 CDS SP70585_0988 NC_012468.1 911587 912087 D identified by match to protein family HMM PF00583; acetyltransferase, gnat family 911587..912087 Streptococcus pneumoniae 70585 7684595 YP_002740255.1 CDS SP70585_0989 NC_012468.1 912090 912317 D TfoX N- domain family protein 912090..912317 Streptococcus pneumoniae 70585 7683529 YP_002740256.1 CDS SP70585_0993 NC_012468.1 914005 914574 D identified by match to protein family HMM PF00583; acetyltransferase, gnat family 914005..914574 Streptococcus pneumoniae 70585 7683888 YP_002740257.1 CDS SP70585_0994 NC_012468.1 914642 915292 D identified by match to protein family HMM PF00633; match to protein family HMM TIGR00426; match to protein family HMM TIGR01259; competence protein 914642..915292 Streptococcus pneumoniae 70585 7684908 YP_002740258.1 CDS SP70585_0995 NC_012468.1 915276 917516 D identified by match to protein family HMM PF03772; match to protein family HMM TIGR00360; match to protein family HMM TIGR00361; DNA internalization-related competence protein ComEC/Rec2 915276..917516 Streptococcus pneumoniae 70585 7683616 YP_002740259.1 CDS SP70585_0996 NC_012468.1 917658 917882 D hypothetical protein 917658..917882 Streptococcus pneumoniae 70585 7683538 YP_002740260.1 CDS SP70585_0997 NC_012468.1 917914 918501 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 917914..918501 Streptococcus pneumoniae 70585 7683234 YP_002740261.1 CDS SP70585_0998 NC_012468.1 918505 919689 D hypothetical protein 918505..919689 Streptococcus pneumoniae 70585 7683046 YP_002740262.1 CDS infC NC_012468.1 919964 920521 D IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 919964..920521 Streptococcus pneumoniae 70585 7684683 YP_002740263.1 CDS rpmI NC_012468.1 920554 920754 D identified by match to protein family HMM PF01632; match to protein family HMM TIGR00001; 50S ribosomal protein L35 920554..920754 Streptococcus pneumoniae 70585 7683967 YP_002740264.1 CDS rplT NC_012468.1 920806 921165 D binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 920806..921165 Streptococcus pneumoniae 70585 7684882 YP_002740265.1 CDS SP70585_1002 NC_012468.1 921223 921603 D identified by match to protein family HMM PF00903; lactoylglutathione lyase 921223..921603 Streptococcus pneumoniae 70585 7684612 YP_002740266.1 CDS SP70585_1003 NC_012468.1 921853 922653 D responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the pyrD subunit to the ultimate electron acceptor NAD(+); dihydroorotate dehydrogenase electron transfer subunit 921853..922653 Streptococcus pneumoniae 70585 7683536 YP_002740267.1 CDS SP70585_1004 NC_012468.1 922664 923602 D catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway, using a flavin nucleotide as an essential cofactor; subclass 1B is a heterotetramer consisting of two PyrDB subunits, similar to the PyrDA subunits and two PyrK subunits; dihydroorotate dehydrogenase 1B 922664..923602 Streptococcus pneumoniae 70585 7682949 YP_002740268.1 CDS SP70585_1005 NC_012468.1 923701 925809 D identified by match to protein family HMM PF01473; match to protein family HMM PF01832; endo-beta-N-acetylglucosaminidase 923701..925809 Streptococcus pneumoniae 70585 7685100 YP_002740269.1 CDS SP70585_1006 NC_012468.1 925870 927525 R identified by match to protein family HMM PF05670; match to protein family HMM PF05833; fibronectin/fibrinogen binding protein complement(925870..927525) Streptococcus pneumoniae 70585 7684498 YP_002740270.1 CDS SP70585_1007 NC_012468.1 927630 928127 D identified by match to protein family HMM PF02130; match to protein family HMM TIGR00043; putative metalloprotease 927630..928127 Streptococcus pneumoniae 70585 7683094 YP_002740271.1 CDS SP70585_1008 NC_012468.1 928108 928503 D identified by match to protein family HMM PF01219; diacylglycerol kinase (dagk) (diglyceride kinase)(dgk) 928108..928503 Streptococcus pneumoniae 70585 7684217 YP_002740272.1 CDS era NC_012468.1 928520 929419 D Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 928520..929419 Streptococcus pneumoniae 70585 7682884 YP_002740273.1 CDS mutM NC_012468.1 929468 930292 D Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 929468..930292 Streptococcus pneumoniae 70585 7682957 YP_002740274.1 CDS coaE NC_012468.1 930292 930897 D catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase 930292..930897 Streptococcus pneumoniae 70585 7684496 YP_002740275.1 CDS SP70585_1012 NC_012468.1 930884 932083 D identified by match to protein family HMM PF07690; multidrug resistance protein MdtG 930884..932083 Streptococcus pneumoniae 70585 7683296 YP_002740276.1 CDS rpmG NC_012468.1 932083 932232 D in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 932083..932232 Streptococcus pneumoniae 70585 7683870 YP_002740277.1 CDS secG NC_012468.1 932272 932505 D identified by match to protein family HMM PF03840; match to protein family HMM TIGR00810; preprotein translocase subunit SecG 932272..932505 Streptococcus pneumoniae 70585 7683386 YP_002740278.1 CDS rnr NC_012468.1 932607 934961 D identified by match to protein family HMM PF00575; match to protein family HMM PF00773; match to protein family HMM PF08206; match to protein family HMM TIGR00358; match to protein family HMM TIGR02063; ribonuclease R 932607..934961 Streptococcus pneumoniae 70585 7684759 YP_002740279.1 CDS smpB NC_012468.1 934924 935391 D binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 934924..935391 Streptococcus pneumoniae 70585 7684547 YP_002740280.1 CDS tehB NC_012468.1 935407 936267 D with TehA confers resistance to tellurite; tellurite resistance protein TehB 935407..936267 Streptococcus pneumoniae 70585 7684393 YP_002740281.1 CDS SP70585_1018 NC_012468.1 936340 937293 D identified by match to protein family HMM PF06054; competence protein 936340..937293 Streptococcus pneumoniae 70585 7684090 YP_002740282.1 CDS pepF1 NC_012468.1 937312 939114 D identified by match to protein family HMM PF01432; match to protein family HMM PF08439; match to protein family HMM TIGR00181; oligoendopeptidase F 937312..939114 Streptococcus pneumoniae 70585 7684996 YP_002740283.1 CDS SP70585_1020 NC_012468.1 939152 939829 D identified by match to protein family HMM PF01596; match to protein family HMM PF08241; O-methyltransferase family protein 939152..939829 Streptococcus pneumoniae 70585 7683447 YP_002740284.1 CDS prsA NC_012468.1 939896 940837 D cis/trans isomerase of peptidylprolyl; PPIase; membrane-bound lipoprotein; foldase PrsA 939896..940837 Streptococcus pneumoniae 70585 7683298 YP_002740285.1 CDS SP70585_1022 NC_012468.1 940954 941295 R transposase OrfB complement(940954..941295) Streptococcus pneumoniae 70585 7684994 YP_002740286.1 CDS SP70585_1023 NC_012468.1 941295 941486 R hypothetical protein complement(941295..941486) Streptococcus pneumoniae 70585 7683963 YP_002740287.1 CDS SP70585_1024 NC_012468.1 941909 942055 D an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; Spn1, transposase Orf2 941909..942055 Streptococcus pneumoniae 70585 7682956 YP_002740288.1 CDS SP70585_1025 NC_012468.1 942056 942676 R identified by match to protein family HMM PF00300; phosphoglycerate mutase complement(942056..942676) Streptococcus pneumoniae 70585 7683114 YP_002740289.1 CDS SP70585_1026 NC_012468.1 942676 943158 R identified by match to protein family HMM PF04073; regulatory protein complement(942676..943158) Streptococcus pneumoniae 70585 7684897 YP_002740290.1 CDS SP70585_1027 NC_012468.1 943158 944000 R identified by match to protein family HMM PF04018; integral membrane protein complement(943158..944000) Streptococcus pneumoniae 70585 7684516 YP_002740291.1 CDS SP70585_1028 NC_012468.1 944095 944895 R identified by match to protein family HMM PF01183; lyzozyme M1 complement(944095..944895) Streptococcus pneumoniae 70585 7684527 YP_002740292.1 CDS glmU NC_012468.1 945039 946418 D forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 945039..946418 Streptococcus pneumoniae 70585 7683487 YP_002740293.1 CDS SP70585_1030 NC_012468.1 946428 946973 D identified by match to protein family HMM PF00293; ADP-ribose pyrophosphatase 946428..946973 Streptococcus pneumoniae 70585 7683264 YP_002740294.1 CDS SP70585_1031 NC_012468.1 946985 947299 D hypothetical protein 946985..947299 Streptococcus pneumoniae 70585 7682933 YP_002740295.1 CDS mtnN NC_012468.1 947316 948008 D enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 947316..948008 Streptococcus pneumoniae 70585 7684682 YP_002740296.1 CDS SP70585_1033 NC_012468.1 948097 948576 D identified by match to protein family HMM PF04394; hypothetical protein 948097..948576 Streptococcus pneumoniae 70585 7683755 YP_002740297.1 CDS SP70585_1034 NC_012468.1 948674 949264 D 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 948674..949264 Streptococcus pneumoniae 70585 7683258 YP_002740298.1 CDS SP70585_1035 NC_012468.1 949273 951036 D identified by match to protein family HMM PF03009; glycerophosphoryl diester phosphodiesterase family protein 949273..951036 Streptococcus pneumoniae 70585 7683069 YP_002740299.1 CDS SP70585_1036 NC_012468.1 951232 951579 D an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01710; transposase 951232..951579 Streptococcus pneumoniae 70585 7684920 YP_002740300.1 CDS SP70585_1037 NC_012468.1 952059 952259 D hypothetical protein 952059..952259 Streptococcus pneumoniae 70585 7683184 YP_002740301.1 CDS SP70585_1038 NC_012468.1 952284 952700 D hypothetical protein 952284..952700 Streptococcus pneumoniae 70585 7683534 YP_002740302.1 CDS SP70585_1039 NC_012468.1 952931 953638 D identified by match to protein family HMM PF02683; cytochrome c-type biogenesis protein CcdA 952931..953638 Streptococcus pneumoniae 70585 7684700 YP_002740303.1 CDS SP70585_1040 NC_012468.1 953649 954206 D identified by match to protein family HMM PF00578; match to protein family HMM PF08534; thioredoxin family protein 953649..954206 Streptococcus pneumoniae 70585 7684202 YP_002740304.1 CDS SP70585_1041 NC_012468.1 954580 955971 D identified by match to protein family HMM PF00324; amino acid permease family protein 954580..955971 Streptococcus pneumoniae 70585 7685097 YP_002740305.1 CDS SP70585_1042 NC_012468.1 956114 957031 D identified by match to protein family HMM PF01297; zinc-binding lipoprotein AdcA 956114..957031 Streptococcus pneumoniae 70585 7682948 YP_002740306.1 CDS SP70585_1043 NC_012468.1 957039 959600 D identified by match to protein family HMM PF04270; match to protein family HMM TIGR01363; pneumococcal histidine triad protein B 957039..959600 Streptococcus pneumoniae 70585 7683324 YP_002740307.1 CDS SP70585_1044 NC_012468.1 959810 962929 D identified by match to protein family HMM PF04270; match to protein family HMM TIGR01363; pneumococcal histidine triad protein E 959810..962929 Streptococcus pneumoniae 70585 7683288 YP_002740308.1 CDS SP70585_1045 NC_012468.1 963759 964328 D identified by match to protein family HMM PF04270; pneumococcal histidine triad protein E 963759..964328 Streptococcus pneumoniae 70585 7685072 YP_002740309.1 CDS SP70585_1046 NC_012468.1 964623 965252 D hypothetical protein 964623..965252 Streptococcus pneumoniae 70585 7683875 YP_002740310.1 CDS pepT NC_012468.1 965288 966511 R catalyzes the release of the N-terminal amino acid from a tripeptide; peptidase T complement(965288..966511) Streptococcus pneumoniae 70585 7683767 YP_002740311.1 CDS hemH NC_012468.1 966665 967759 D identified by match to protein family HMM PF00762; match to protein family HMM TIGR00109; ferrochelatase 966665..967759 Streptococcus pneumoniae 70585 7684474 YP_002740312.1 CDS mscL NC_012468.1 967801 968178 R identified by match to protein family HMM PF01741; match to protein family HMM TIGR00220; large conductance mechanosensitive channel protein complement(967801..968178) Streptococcus pneumoniae 70585 7684909 YP_002740313.1 CDS SP70585_1050 NC_012468.1 968260 968691 R identified by match to protein family HMM PF04138; MesH protein complement(968260..968691) Streptococcus pneumoniae 70585 7684813 YP_002740314.1 CDS SP70585_1051 NC_012468.1 968814 969323 D identified by match to protein family HMM PF06177; citrulline cluster-linked protein 968814..969323 Streptococcus pneumoniae 70585 7684150 YP_002740315.1 CDS asd NC_012468.1 969837 970913 D catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 969837..970913 Streptococcus pneumoniae 70585 7684305 YP_002740316.1 CDS dapA NC_012468.1 970969 971904 D catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase 970969..971904 Streptococcus pneumoniae 70585 7684749 YP_002740317.1 CDS trmE NC_012468.1 971951 973324 R in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE complement(971951..973324) Streptococcus pneumoniae 70585 7682883 YP_002740318.1 CDS SP70585_1056 NC_012468.1 973461 973643 R 4-OT; member of subfamily 5; forms a dimer; the function in the Escherichia coli cell is unknown; 4-oxalocrotonate tautomerase complement(973461..973643) Streptococcus pneumoniae 70585 7683931 YP_002740319.1 CDS tdk NC_012468.1 973766 974365 D catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 973766..974365 Streptococcus pneumoniae 70585 7684520 YP_002740320.1 CDS SP70585_1058 NC_012468.1 974355 974834 D identified by match to protein family HMM PF00583; acetyltransferase, gnat family 974355..974834 Streptococcus pneumoniae 70585 7684825 YP_002740321.1 CDS prfA NC_012468.1 974844 975923 D recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 974844..975923 Streptococcus pneumoniae 70585 7683740 YP_002740322.1 CDS hemK NC_012468.1 975923 976762 D identified by match to protein family HMM PF05175; match to protein family HMM PF08241; match to protein family HMM PF08242; match to protein family HMM TIGR00536; match to protein family HMM TIGR03387; protein-(glutamine-N5) methyltransferase, release factor-specific 975923..976762 Streptococcus pneumoniae 70585 7683986 YP_002740323.1 CDS SP70585_1061 NC_012468.1 976746 977348 D identified by match to protein family HMM PF01300; match to protein family HMM TIGR00057; Sua5/YciO/YrdC/YwlC family protein 976746..977348 Streptococcus pneumoniae 70585 7683449 YP_002740324.1 CDS SP70585_1062 NC_012468.1 977350 977781 D identified by match to protein family HMM PF00583; acetyltransferase, gnat family 977350..977781 Streptococcus pneumoniae 70585 7684900 YP_002740325.1 CDS glyA NC_012468.1 977843 979099 D catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 977843..979099 Streptococcus pneumoniae 70585 7684190 YP_002740326.1 CDS SP70585_1064 NC_012468.1 979107 980081 D hypothetical protein 979107..980081 Streptococcus pneumoniae 70585 7684731 YP_002740327.1 CDS SP70585_1065 NC_012468.1 980081 980695 D pneumococcal vaccine antigen A 980081..980695 Streptococcus pneumoniae 70585 7683054 YP_002740328.1 CDS SP70585_1066 NC_012468.1 980769 981743 D identified by match to protein family HMM PF06207; hypothetical protein 980769..981743 Streptococcus pneumoniae 70585 7684390 YP_002740329.1 CDS rumA1 NC_012468.1 981817 983178 D identified by match to protein family HMM PF01938; match to protein family HMM PF05958; match to protein family HMM TIGR00479; 23S rRNA (uracil-5-)-methyltransferase RumA 981817..983178 Streptococcus pneumoniae 70585 7684566 YP_002740330.1 CDS SP70585_1068 NC_012468.1 983145 983312 D hypothetical protein 983145..983312 Streptococcus pneumoniae 70585 7684964 YP_002740331.1 CDS SP70585_1069 NC_012468.1 983390 983563 D hypothetical protein 983390..983563 Streptococcus pneumoniae 70585 7684196 YP_002740332.1 CDS SP70585_1070 NC_012468.1 983560 984369 D identified by match to protein family HMM PF06970; replication initiator protein A (RepA) N-terminus 983560..984369 Streptococcus pneumoniae 70585 7684879 YP_002740333.1 CDS SP70585_1071 NC_012468.1 984527 985882 D identified by match to protein family HMM PF00145; match to protein family HMM TIGR00675; methyl transferase 984527..985882 Streptococcus pneumoniae 70585 7684476 YP_002740334.1 CDS SP70585_1072 NC_012468.1 985866 986294 D hypothetical protein 985866..986294 Streptococcus pneumoniae 70585 7683524 YP_002740335.1 CDS SP70585_1073 NC_012468.1 986305 986688 D arsenate reductase-like glutaredoxin family member 986305..986688 Streptococcus pneumoniae 70585 7683277 YP_002740336.1 CDS SP70585_1074 NC_012468.1 986697 986930 D hypothetical protein 986697..986930 Streptococcus pneumoniae 70585 7685172 YP_002740337.1 CDS SP70585_1075 NC_012468.1 987008 987517 D identified by match to protein family HMM PF02517; protease, putative 987008..987517 Streptococcus pneumoniae 70585 7684141 YP_002740338.1 CDS SP70585_1076 NC_012468.1 987558 988082 D hypothetical protein 987558..988082 Streptococcus pneumoniae 70585 7683736 YP_002740339.1 CDS SP70585_1077 NC_012468.1 988118 989899 D identified by match to protein family HMM PF02534; TraG/TraD family protein 988118..989899 Streptococcus pneumoniae 70585 7685007 YP_002740340.1 CDS SP70585_1078 NC_012468.1 989917 990159 D hypothetical protein 989917..990159 Streptococcus pneumoniae 70585 7683018 YP_002740341.1 CDS SP70585_1079 NC_012468.1 990178 991032 D hypothetical protein 990178..991032 Streptococcus pneumoniae 70585 7685182 YP_002740342.1 CDS SP70585_1080 NC_012468.1 991094 991447 D hypothetical protein 991094..991447 Streptococcus pneumoniae 70585 7683391 YP_002740343.1 CDS SP70585_1083 NC_012468.1 993731 996532 D identified by match to protein family HMM PF05257; CHAP domain protein 993731..996532 Streptococcus pneumoniae 70585 7685061 YP_002740344.1 CDS SP70585_1084 NC_012468.1 996600 997202 D hypothetical protein 996600..997202 Streptococcus pneumoniae 70585 7682996 YP_002740345.1 CDS SP70585_1085 NC_012468.1 997205 998179 D identified by match to protein family HMM PF08843; hypothetical protein 997205..998179 Streptococcus pneumoniae 70585 7683883 YP_002740346.1 CDS SP70585_1086 NC_012468.1 998197 998466 D hypothetical protein 998197..998466 Streptococcus pneumoniae 70585 7685018 YP_002740347.1 CDS SP70585_1087 NC_012468.1 999627 1000580 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF00665; transposase complement(999627..1000580) Streptococcus pneumoniae 70585 7683781 YP_002740348.1 CDS SP70585_1088 NC_012468.1 1000939 1001316 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01609; transposase (IS4 family) complement(1000939..1001316) Streptococcus pneumoniae 70585 7683352 YP_002740349.1 CDS SP70585_1089 NC_012468.1 1001328 1001789 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase complement(1001328..1001789) Streptococcus pneumoniae 70585 7683377 YP_002740350.1 CDS SP70585_1090 NC_012468.1 1001779 1002345 R putative phosphatase H16_A0669 complement(1001779..1002345) Streptococcus pneumoniae 70585 7684598 YP_002740351.1 CDS SP70585_1091 NC_012468.1 1002446 1002589 R drug-resistant methionyl-tRNA synthetase complement(1002446..1002589) Streptococcus pneumoniae 70585 7685011 YP_002740352.1 CDS SP70585_1092 NC_012468.1 1002644 1003222 D identified by match to protein family HMM PF00302; chloramphenicol O-acetyltransferase 1002644..1003222 Streptococcus pneumoniae 70585 7685160 YP_002740353.1 CDS metG2 NC_012468.1 1003290 1004927 D methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 1003290..1004927 Streptococcus pneumoniae 70585 7683333 YP_002740354.1 CDS SP70585_1094 NC_012468.1 1005028 1005594 D putative phosphatase H16_A0669 1005028..1005594 Streptococcus pneumoniae 70585 7683250 YP_002740355.1 CDS SP70585_1095 NC_012468.1 1005584 1006045 D an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase 1005584..1006045 Streptococcus pneumoniae 70585 7683583 YP_002740356.1 CDS SP70585_1096 NC_012468.1 1006057 1006434 D an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01609; transposase (IS4 family) 1006057..1006434 Streptococcus pneumoniae 70585 7684078 YP_002740357.1 CDS SP70585_1097 NC_012468.1 1006507 1006668 D protein tyrosine phosphatase, putative 1006507..1006668 Streptococcus pneumoniae 70585 7684651 YP_002740358.1 CDS SP70585_1098 NC_012468.1 1007691 1008677 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1007691..1008677 Streptococcus pneumoniae 70585 7683074 YP_002740359.1 CDS SP70585_1101 NC_012468.1 1009500 1010285 D identified by match to protein family HMM PF06182; ABC transporter permease 1009500..1010285 Streptococcus pneumoniae 70585 7685062 YP_002740360.1 CDS SP70585_1105 NC_012468.1 1012361 1012564 D identified by match to protein family HMM PF01381; hypothetical protein 1012361..1012564 Streptococcus pneumoniae 70585 7683110 YP_002740361.1 CDS SP70585_1106 NC_012468.1 1012695 1012847 D identified by glimmer; putative; hypothetical protein 1012695..1012847 Streptococcus pneumoniae 70585 7685098 YP_002740362.1 CDS SP70585_1109 NC_012468.1 1014847 1015083 D tRNA 1014847..1015083 Streptococcus pneumoniae 70585 7683702 YP_002740363.1 CDS SP70585_1110 NC_012468.1 1015821 1016039 D hypothetical protein 1015821..1016039 Streptococcus pneumoniae 70585 7683203 YP_002740364.1 CDS SP70585_1111 NC_012468.1 1016043 1016312 D identified by glimmer; putative; hypothetical protein 1016043..1016312 Streptococcus pneumoniae 70585 7683598 YP_002740365.1 CDS SP70585_1112 NC_012468.1 1016433 1017458 D identified by match to protein family HMM PF01497; ABC transporter substrate-binding protein - iron transport 1016433..1017458 Streptococcus pneumoniae 70585 7684808 YP_002740366.1 CDS SP70585_1113 NC_012468.1 1017448 1018455 D identified by match to protein family HMM PF01032; iron-compound ABC transporter permease 1017448..1018455 Streptococcus pneumoniae 70585 7684930 YP_002740367.1 CDS SP70585_1114 NC_012468.1 1018455 1019462 D identified by match to protein family HMM PF01032; Fe3+ ABC transporter permease 1018455..1019462 Streptococcus pneumoniae 70585 7683132 YP_002740368.1 CDS SP70585_1115 NC_012468.1 1019462 1020256 D identified by match to protein family HMM PF00005; ferric enterobactin transport ATP-binding protein FepC 1019462..1020256 Streptococcus pneumoniae 70585 7683225 YP_002740369.1 CDS SP70585_1116 NC_012468.1 1020824 1021033 D identified by match to protein family HMM PF07674; hypothetical protein 1020824..1021033 Streptococcus pneumoniae 70585 7683833 YP_002740370.1 CDS SP70585_1117 NC_012468.1 1021182 1021313 D hypothetical protein 1021182..1021313 Streptococcus pneumoniae 70585 7684855 YP_002740371.1 CDS SP70585_1118 NC_012468.1 1021997 1022158 D hypothetical protein 1021997..1022158 Streptococcus pneumoniae 70585 7683684 YP_002740372.1 CDS SP70585_1119 NC_012468.1 1022250 1023929 D Low similarity to site-specific recombinase; identified by match to protein family HMM PF00239; match to protein family HMM PF07508; site-specific recombinase-like protein 1022250..1023929 Streptococcus pneumoniae 70585 7683466 YP_002740373.1 CDS SP70585_1120 NC_012468.1 1024197 1024763 D hypothetical protein 1024197..1024763 Streptococcus pneumoniae 70585 7684946 YP_002740374.1 CDS SP70585_1121 NC_012468.1 1025085 1025273 D hypothetical protein 1025085..1025273 Streptococcus pneumoniae 70585 7684392 YP_002740375.1 CDS SP70585_1122 NC_012468.1 1025335 1026093 D hypothetical protein 1025335..1026093 Streptococcus pneumoniae 70585 7684551 YP_002740376.1 CDS SP70585_1123 NC_012468.1 1026151 1027005 D identified by match to protein family HMM PF03747; ADP-ribosylglycohydrolase superfamily 1026151..1027005 Streptococcus pneumoniae 70585 7684927 YP_002740377.1 CDS SP70585_1124 NC_012468.1 1027117 1028001 D identified by match to protein family HMM PF00781; match to protein family HMM TIGR00147; hypothetical protein 1027117..1028001 Streptococcus pneumoniae 70585 7684796 YP_002740378.1 CDS SP70585_1125 NC_012468.1 1028305 1029903 D identified by match to protein family HMM PF00128; match to protein family HMM PF02903; neopullulanase 1028305..1029903 Streptococcus pneumoniae 70585 7684187 YP_002740379.1 CDS SP70585_1126 NC_012468.1 1030178 1030633 D hypothetical protein 1030178..1030633 Streptococcus pneumoniae 70585 7682989 YP_002740380.1 CDS SP70585_1127 NC_012468.1 1030773 1030886 D hypothetical protein 1030773..1030886 Streptococcus pneumoniae 70585 7684553 YP_002740381.1 CDS SP70585_1128 NC_012468.1 1031078 1031554 D identified by match to protein family HMM PF01381; helix-turn-helix domain protein 1031078..1031554 Streptococcus pneumoniae 70585 7684377 YP_002740382.1 CDS SP70585_1129 NC_012468.1 1031554 1032315 D identified by match to protein family HMM PF06414; signal recognition particle GTPase 1031554..1032315 Streptococcus pneumoniae 70585 7683321 YP_002740383.1 CDS SP70585_1130 NC_012468.1 1032343 1033500 D hypothetical protein 1032343..1033500 Streptococcus pneumoniae 70585 7683829 YP_002740384.1 CDS SP70585_1131 NC_012468.1 1034332 1034691 D hypothetical protein 1034332..1034691 Streptococcus pneumoniae 70585 7684945 YP_002740385.1 CDS SP70585_1132 NC_012468.1 1034701 1035066 D identified by match to protein family HMM PF05713; putative mobilization protein MobC 1034701..1035066 Streptococcus pneumoniae 70585 7685038 YP_002740386.1 CDS SP70585_1137 NC_012468.1 1037153 1038118 D identified by match to protein family HMM PF01820; match to protein family HMM PF07478; match to protein family HMM TIGR01205; D-alanine--D-alanine ligase B (D-alanylalanine synthetaseB) (D-Ala-D-Ala ligase B) 1037153..1038118 Streptococcus pneumoniae 70585 7685074 YP_002740387.1 CDS SP70585_1138 NC_012468.1 1038517 1038645 D transposase 1038517..1038645 Streptococcus pneumoniae 70585 7683969 YP_002740388.1 CDS SP70585_1139 NC_012468.1 1038902 1039330 D identified by match to protein family HMM PF00583; aminoglycoside 6'-N-acetyltransferase 1038902..1039330 Streptococcus pneumoniae 70585 7683573 YP_002740389.1 CDS SP70585_1140 NC_012468.1 1039388 1039996 D identified by glimmer; putative; hypothetical protein 1039388..1039996 Streptococcus pneumoniae 70585 7684108 YP_002740390.1 CDS SP70585_1141 NC_012468.1 1041087 1042316 D identified by match to protein family HMM PF01098; cell division protein FtsW 1041087..1042316 Streptococcus pneumoniae 70585 7685028 YP_002740391.1 CDS ppc NC_012468.1 1042336 1045032 D catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase 1042336..1045032 Streptococcus pneumoniae 70585 7684747 YP_002740392.1 CDS SP70585_1143 NC_012468.1 1045445 1046449 D identified by match to protein family HMM PF04392; ABC transporter substrate-binding protein 1045445..1046449 Streptococcus pneumoniae 70585 7683992 YP_002740393.1 CDS SP70585_1144 NC_012468.1 1046518 1047384 D identified by match to protein family HMM PF02653; ABC transporter 1046518..1047384 Streptococcus pneumoniae 70585 7684627 YP_002740394.1 CDS SP70585_1145 NC_012468.1 1047381 1048139 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1047381..1048139 Streptococcus pneumoniae 70585 7682914 YP_002740395.1 CDS dnaG NC_012468.1 1048229 1049989 D synthesizes RNA primers at the replication forks; DNA primase 1048229..1049989 Streptococcus pneumoniae 70585 7683289 YP_002740396.1 CDS SP70585_1147 NC_012468.1 1049992 1051101 D sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; primary sigma factor of bacterium; RNA polymerase sigma factor RpoD 1049992..1051101 Streptococcus pneumoniae 70585 7684027 YP_002740397.1 CDS SP70585_1148 NC_012468.1 1051115 1051444 D identified by match to protein family HMM PF01883; N-6 Adenine-specific DNA methylase YitW 1051115..1051444 Streptococcus pneumoniae 70585 7683677 YP_002740398.1 CDS SP70585_1149 NC_012468.1 1051559 1052602 D identified by match to protein family HMM PF00534; glycosyl transferase CpoA 1051559..1052602 Streptococcus pneumoniae 70585 7683008 YP_002740399.1 CDS SP70585_1150 NC_012468.1 1052618 1053943 D identified by match to protein family HMM PF00534; glycosyl transferase, group 1 1052618..1053943 Streptococcus pneumoniae 70585 7684842 YP_002740400.1 CDS SP70585_1151 NC_012468.1 1053974 1054150 D identified by match to protein family HMM PF04024; hypothetical protein 1053974..1054150 Streptococcus pneumoniae 70585 7683550 YP_002740401.1 CDS SP70585_1152 NC_012468.1 1054209 1054343 D hypothetical protein 1054209..1054343 Streptococcus pneumoniae 70585 7683876 YP_002740402.1 CDS obgE NC_012468.1 1054413 1055717 D essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 1054413..1055717 Streptococcus pneumoniae 70585 7684805 YP_002740403.1 CDS SP70585_1154 NC_012468.1 1055727 1055885 D hypothetical protein 1055727..1055885 Streptococcus pneumoniae 70585 7685129 YP_002740404.1 CDS murA1 NC_012468.1 1056972 1058231 D adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1056972..1058231 Streptococcus pneumoniae 70585 7683067 YP_002740405.1 CDS SP70585_1156 NC_012468.1 1058247 1058798 D identified by match to protein family HMM PF00583; acetyltransferase, gnat family protein 1058247..1058798 Streptococcus pneumoniae 70585 7684348 YP_002740406.1 CDS SP70585_1157 NC_012468.1 1058791 1060068 D identified by match to protein family HMM PF00571; match to protein family HMM PF07085; match to protein family HMM PF08279; cytosolic protein containing multiple CBS domains 1058791..1060068 Streptococcus pneumoniae 70585 7684836 YP_002740407.1 CDS map NC_012468.1 1060084 1060944 D catalyzes the removal of N-terminal amino acids from peptides and arylamides; methionine aminopeptidase 1060084..1060944 Streptococcus pneumoniae 70585 7685134 YP_002740408.1 CDS SP70585_1159 NC_012468.1 1061324 1061548 D an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; mobile genetic element 1061324..1061548 Streptococcus pneumoniae 70585 7683163 YP_002740409.1 CDS SP70585_1160 NC_012468.1 1061659 1062048 D identified by match to protein family HMM PF01609; transposase (IS4 family) 1061659..1062048 Streptococcus pneumoniae 70585 7682960 YP_002740410.1 CDS pcrA NC_012468.1 1062231 1064522 D identified by match to protein family HMM PF00580; match to protein family HMM TIGR01073; ATP-dependent DNA helicase PcrA 1062231..1064522 Streptococcus pneumoniae 70585 7683856 YP_002740411.1 CDS radC NC_012468.1 1064565 1065245 D Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase; DNA repair protein RadC 1064565..1065245 Streptococcus pneumoniae 70585 7685029 YP_002740412.1 CDS SP70585_1162 NC_012468.1 1065242 1065931 R identified by match to protein family HMM PF00117; match to protein family HMM PF07722; glutamine amidotransferase, class I complement(1065242..1065931) Streptococcus pneumoniae 70585 7683580 YP_002740413.1 CDS SP70585_1164 NC_012468.1 1065949 1066590 R modulates transcription in response to the NADH/NAD(+) redox state; redox-sensing transcriptional repressor Rex complement(1065949..1066590) Streptococcus pneumoniae 70585 7683171 YP_002740414.1 CDS SP70585_1165 NC_012468.1 1066673 1066816 R hypothetical protein complement(1066673..1066816) Streptococcus pneumoniae 70585 7683850 YP_002740415.1 CDS SP70585_1166 NC_012468.1 1066896 1067243 R identified by match to protein family HMM PF08866; hypothetical protein complement(1066896..1067243) Streptococcus pneumoniae 70585 7683317 YP_002740416.1 CDS SP70585_1167 NC_012468.1 1067248 1068363 R identified by match to protein family HMM PF00266; putative cysteine desulfurase (NifS protein homolog) complement(1067248..1068363) Streptococcus pneumoniae 70585 7682931 YP_002740417.1 CDS SP70585_1168 NC_012468.1 1068373 1069332 R catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase complement(1068373..1069332) Streptococcus pneumoniae 70585 7684414 YP_002740418.1 CDS SP70585_1169 NC_012468.1 1069442 1070011 R identified by match to protein family HMM PF01928; adenylate cyclase complement(1069442..1070011) Streptococcus pneumoniae 70585 7683118 YP_002740419.1 CDS SP70585_1170 NC_012468.1 1070139 1070810 D identified by match to protein family HMM PF04607; GTP pyrophosphokinase 1070139..1070810 Streptococcus pneumoniae 70585 7684827 YP_002740420.1 CDS ppnK NC_012468.1 1070794 1071612 D catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 1070794..1071612 Streptococcus pneumoniae 70585 7683555 YP_002740421.1 CDS SP70585_1172 NC_012468.1 1071609 1072505 D identified by match to protein family HMM PF00849; match to protein family HMM TIGR00005; ribosomal large subunit pseudouridine synthase, RluD subfamily 1071609..1072505 Streptococcus pneumoniae 70585 7684708 YP_002740422.1 CDS eutD NC_012468.1 1072549 1073523 D in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta; phosphotransacetylase 1072549..1073523 Streptococcus pneumoniae 70585 7685108 YP_002740423.1 CDS SP70585_1174 NC_012468.1 1073864 1074163 R identified by match to protein family HMM PF02575; match to protein family HMM TIGR00103; hypothetical protein complement(1073864..1074163) Streptococcus pneumoniae 70585 7683190 YP_002740424.1 CDS SP70585_1175 NC_012468.1 1074565 1075263 D identified by match to protein family HMM PF06912; hypothetical protein 1074565..1075263 Streptococcus pneumoniae 70585 7683372 YP_002740425.1 CDS rplU NC_012468.1 1075451 1075765 D identified by match to protein family HMM PF00829; match to protein family HMM TIGR00061; 50S ribosomal protein L21 1075451..1075765 Streptococcus pneumoniae 70585 7683063 YP_002740426.1 CDS SP70585_1177 NC_012468.1 1075781 1076125 D identified by match to protein family HMM PF04327; hypothetical protein 1075781..1076125 Streptococcus pneumoniae 70585 7684264 YP_002740427.1 CDS rpmA NC_012468.1 1076142 1076435 D involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 1076142..1076435 Streptococcus pneumoniae 70585 7684335 YP_002740428.1 CDS SP70585_1179 NC_012468.1 1076675 1076845 R hypothetical protein complement(1076675..1076845) Streptococcus pneumoniae 70585 7684850 YP_002740429.1 CDS SP70585_1180 NC_012468.1 1076817 1076945 R hypothetical protein complement(1076817..1076945) Streptococcus pneumoniae 70585 7683104 YP_002740430.1 CDS ribF NC_012468.1 1077283 1078200 D catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 1077283..1078200 Streptococcus pneumoniae 70585 7683371 YP_002740431.1 CDS SP70585_1182 NC_012468.1 1078293 1079141 R identified by match to protein family HMM PF02588; hypothetical protein complement(1078293..1079141) Streptococcus pneumoniae 70585 7684191 YP_002740432.1 CDS SP70585_1183 NC_012468.1 1079283 1080122 D identified by match to protein family HMM PF02645; match to protein family HMM TIGR00762; hypothetical protein 1079283..1080122 Streptococcus pneumoniae 70585 7683656 YP_002740433.1 CDS SP70585_1184 NC_012468.1 1080229 1080504 D identified by match to protein family HMM PF00216; DNA-binding protein HU 1 (DNA-binding protein II) (HB) 1080229..1080504 Streptococcus pneumoniae 70585 7683343 YP_002740434.1 CDS SP70585_1185 NC_012468.1 1080930 1082831 D identified by match to protein family HMM PF00005; ATPase component of ABC transporter with duplicated ATPase domains 1080930..1082831 Streptococcus pneumoniae 70585 7684359 YP_002740435.1 CDS SP70585_1186 NC_012468.1 1082834 1083697 D identified by match to protein family HMM TIGR01716; transcriptional regulator 1082834..1083697 Streptococcus pneumoniae 70585 7683958 YP_002740436.1 CDS SP70585_1187 NC_012468.1 1083777 1084955 D identified by match to protein family HMM PF07690; macrolide ABC transporter permease 1083777..1084955 Streptococcus pneumoniae 70585 7683247 YP_002740437.1 CDS ligA NC_012468.1 1085048 1087006 D this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA 1085048..1087006 Streptococcus pneumoniae 70585 7684799 YP_002740438.1 CDS pulA NC_012468.1 1087118 1089397 D identified by match to protein family HMM PF00128; match to protein family HMM PF02922; match to protein family HMM TIGR02104; pullulanase, type I 1087118..1089397 Streptococcus pneumoniae 70585 7683080 YP_002740439.1 CDS SP70585_1190 NC_012468.1 1089942 1091366 D identified by match to protein family HMM PF00171; NADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1089942..1091366 Streptococcus pneumoniae 70585 7684071 YP_002740440.1 CDS glgB NC_012468.1 1091828 1093756 D catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching enzyme 1091828..1093756 Streptococcus pneumoniae 70585 7683733 YP_002740441.1 CDS glgC NC_012468.1 1093746 1094888 D catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 1093746..1094888 Streptococcus pneumoniae 70585 7685032 YP_002740442.1 CDS glgD NC_012468.1 1094878 1096017 D identified by match to protein family HMM PF00483; match to protein family HMM TIGR02092; glucose-1-phosphate adenylyltransferase, GlgD subunit 1094878..1096017 Streptococcus pneumoniae 70585 7684101 YP_002740443.1 CDS glgA NC_012468.1 1096014 1097447 D catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose; glycogen synthase 1096014..1097447 Streptococcus pneumoniae 70585 7682990 YP_002740444.1 CDS SP70585_1198 NC_012468.1 1098160 1099275 D identified by match to protein family HMM PF02595; match to protein family HMM TIGR00045; glycerate kinase 1098160..1099275 Streptococcus pneumoniae 70585 7685126 YP_002740445.1 CDS SP70585_1197 NC_012468.1 1099272 1099718 R identified by match to protein family HMM PF07997; hypothetical protein complement(1099272..1099718) Streptococcus pneumoniae 70585 7685082 YP_002740446.1 CDS eno NC_012468.1 1099882 1101186 D enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 1099882..1101186 Streptococcus pneumoniae 70585 7684779 YP_002740447.1 CDS SP70585_1200 NC_012468.1 1101218 1101343 D identified by glimmer; putative; hypothetical protein 1101218..1101343 Streptococcus pneumoniae 70585 7683442 YP_002740448.1 CDS SP70585_1203 NC_012468.1 1102258 1102611 R identified by match to protein family HMM PF01710; transposase complement(1102258..1102611) Streptococcus pneumoniae 70585 7683564 YP_002740449.1 CDS rexB NC_012468.1 1103137 1106412 D identified by match to protein family HMM TIGR02774; ATP-dependent nuclease subunit B 1103137..1106412 Streptococcus pneumoniae 70585 7684773 YP_002740450.1 CDS addA NC_012468.1 1106409 1110059 D identified by match to protein family HMM PF00580; match to protein family HMM TIGR02785; recombination helicase AddA 1106409..1110059 Streptococcus pneumoniae 70585 7684975 YP_002740451.1 CDS SP70585_1206 NC_012468.1 1110229 1111407 D hypothetical protein 1110229..1111407 Streptococcus pneumoniae 70585 7683187 YP_002740452.1 CDS SP70585_1207 NC_012468.1 1111616 1117447 D identified by match to protein family HMM PF00746; match to protein family HMM PF04650; match to protein family HMM PF05342; match to protein family HMM PF07501; match to protein family HMM PF07580; match to protein family HMM PF07581; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; immunoglobulin A1 protease 1111616..1117447 Streptococcus pneumoniae 70585 7684104 YP_002740453.1 CDS rbgA NC_012468.1 1117895 1118746 D essential GTPase; functions in ribosome assembly; binds a unique part of the 23S rRNA; interacts with ribosomal protein L25(Ctc); ribosomal biogenesis GTPase 1117895..1118746 Streptococcus pneumoniae 70585 7682982 YP_002740454.1 CDS rnhB NC_012468.1 1118733 1119512 D RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 1118733..1119512 Streptococcus pneumoniae 70585 7683805 YP_002740455.1 CDS SP70585_1210 NC_012468.1 1119528 1121078 D identified by match to protein family HMM PF00654; match to protein family HMM PF02080; voltage-gated chloride channel family protein 1119528..1121078 Streptococcus pneumoniae 70585 7684061 YP_002740456.1 CDS xerS NC_012468.1 1121664 1122734 D site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerS; site-specific tyrosine recombinase XerS 1121664..1122734 Streptococcus pneumoniae 70585 7683540 YP_002740457.1 CDS SP70585_1212 NC_012468.1 1122807 1123796 R identified by match to protein family HMM PF03099; match to protein family HMM TIGR00545; lipoate protein ligase A complement(1122807..1123796) Streptococcus pneumoniae 70585 7684188 YP_002740458.1 CDS lpdA NC_012468.1 1123860 1125563 R identified by match to protein family HMM PF00070; match to protein family HMM PF00364; match to protein family HMM PF01134; match to protein family HMM PF02852; match to protein family HMM PF03486; match to protein family HMM PF07992; match to protein family HMM TIGR01350; dihydrolipoyl dehydrogenase complement(1123860..1125563) Streptococcus pneumoniae 70585 7684274 YP_002740459.1 CDS SP70585_1214 NC_012468.1 1125609 1126652 R unlike PdhC proteins from other organisms, some Mycoplasma lack an N-terminal lipoyl domain; in Mycoplasma hyopneumonia the PdhD proteins contains the lipoyl domain; dihydrolipoamide acetyltransferase complement(1125609..1126652) Streptococcus pneumoniae 70585 7684477 YP_002740460.1 CDS SP70585_1215 NC_012468.1 1126870 1127862 R identified by match to protein family HMM PF02779; match to protein family HMM PF02780; pyruvate dehydrogenase E1 component subunit beta complement(1126870..1127862) Streptococcus pneumoniae 70585 7683376 YP_002740461.1 CDS SP70585_1216 NC_012468.1 1127878 1128846 R identified by match to protein family HMM PF00676; pyruvate dehydrogenase E1 component subunit alpha complement(1127878..1128846) Streptococcus pneumoniae 70585 7684593 YP_002740462.1 CDS SP70585_1217 NC_012468.1 1129000 1130361 R identified by match to protein family HMM PF01554; match to protein family HMM TIGR00797; mate efflux family protein complement(1129000..1130361) Streptococcus pneumoniae 70585 7685023 YP_002740463.1 CDS pyrC NC_012468.1 1130646 1131914 R catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase complement(1130646..1131914) Streptococcus pneumoniae 70585 7684201 YP_002740464.1 CDS SP70585_1219 NC_012468.1 1131927 1132391 R identified by match to protein family HMM PF00293; mutator MutT protein (7,8-dihydro-8-oxoguanine-triphosphatase) (8-oxo-dGTPase) (dGTP pyrophosphohydrolase) complement(1131927..1132391) Streptococcus pneumoniae 70585 7683181 YP_002740465.1 CDS ung NC_012468.1 1132401 1133069 R Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase complement(1132401..1133069) Streptococcus pneumoniae 70585 7684679 YP_002740466.1 CDS SP70585_1221 NC_012468.1 1133192 1133515 R hypothetical protein complement(1133192..1133515) Streptococcus pneumoniae 70585 7683130 YP_002740467.1 CDS SP70585_1222 NC_012468.1 1133828 1134541 R identified by match to protein family HMM PF00702; match to protein family HMM TIGR01549; match to protein family HMM TIGR02254; HAD superfamily (subfamily IA) hydrolase complement(1133828..1134541) Streptococcus pneumoniae 70585 7683297 YP_002740468.1 CDS SP70585_1223 NC_012468.1 1134602 1135540 R identified by match to protein family HMM PF08867; FRG domain family complement(1134602..1135540) Streptococcus pneumoniae 70585 7684628 YP_002740469.1 CDS SP70585_1224 NC_012468.1 1135705 1135917 R mobile genetic element complement(1135705..1135917) Streptococcus pneumoniae 70585 7683971 YP_002740470.1 CDS SP70585_1225 NC_012468.1 1135993 1136367 R identified by glimmer; putative; hypothetical protein complement(1135993..1136367) Streptococcus pneumoniae 70585 7684171 YP_002740471.1 CDS SP70585_1226 NC_012468.1 1136510 1139032 R identified by match to protein family HMM PF04270; match to protein family HMM TIGR01363; pneumococcal histidine triad protein B complement(1136510..1139032) Streptococcus pneumoniae 70585 7684052 YP_002740472.1 CDS SP70585_1227 NC_012468.1 1139190 1141643 R identified by match to protein family HMM PF04270; match to protein family HMM TIGR01363; pneumococcal histidine triad protein B complement(1139190..1141643) Streptococcus pneumoniae 70585 7682977 YP_002740473.1 CDS SP70585_1229 NC_012468.1 1141764 1141901 D identified by glimmer; putative; hypothetical protein 1141764..1141901 Streptococcus pneumoniae 70585 7684913 YP_002740474.1 CDS ptsP NC_012468.1 1141898 1143631 R identified by match to protein family HMM PF00391; match to protein family HMM PF02896; match to protein family HMM PF05524; match to protein family HMM TIGR01417; phosphoenolpyruvate-protein phosphotransferase complement(1141898..1143631) Streptococcus pneumoniae 70585 7683585 YP_002740475.1 CDS SP70585_1230 NC_012468.1 1143637 1143900 R identified by match to protein family HMM PF00381; match to protein family HMM TIGR01003; phosphocarrier protein HPr complement(1143637..1143900) Streptococcus pneumoniae 70585 7683827 YP_002740476.1 CDS SP70585_1231 NC_012468.1 1144251 1144469 D identified by match to protein family HMM PF00462; match to protein family HMM TIGR02194; glutaredoxin 1144251..1144469 Streptococcus pneumoniae 70585 7684402 YP_002740477.1 CDS SP70585_1232 NC_012468.1 1144550 1146709 D Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 1144550..1146709 Streptococcus pneumoniae 70585 7683346 YP_002740478.1 CDS nrdF NC_012468.1 1146897 1147859 D B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 1146897..1147859 Streptococcus pneumoniae 70585 7684585 YP_002740479.1 CDS SP70585_1234 NC_012468.1 1148041 1148802 D identified by match to protein family HMM PF00455; match to protein family HMM PF08220; match to protein family HMM PF08279; lactose phosphotransferase system repressor 1148041..1148802 Streptococcus pneumoniae 70585 7684415 YP_002740480.1 CDS SP70585_1235 NC_012468.1 1149081 1149260 R hypothetical protein complement(1149081..1149260) Streptococcus pneumoniae 70585 7683178 YP_002740481.1 CDS lacG2 NC_012468.1 1149383 1150789 R catalyzes the formation of 6-phospho-galactose from a 6-phospho-beta-galactoside; 6-phospho-beta-galactosidase complement(1149383..1150789) Streptococcus pneumoniae 70585 7685189 YP_002740482.1 CDS SP70585_1237 NC_012468.1 1151004 1152695 R identified by match to protein family HMM PF02302; match to protein family HMM PF02378; match to protein family HMM TIGR00394; match to protein family HMM TIGR00410; match to protein family HMM TIGR00853; PTS system, lactose-specific IIC component complement(1151004..1152695) Streptococcus pneumoniae 70585 7684220 YP_002740483.1 CDS SP70585_1238 NC_012468.1 1152695 1153012 R identified by match to protein family HMM PF02255; match to protein family HMM TIGR00823; lactose-specific phosphotransferase enzyme iia component (pts system lactose-specific eiia component) (eiia-lac) (eiii-lac) complement(1152695..1153012) Streptococcus pneumoniae 70585 7683062 YP_002740484.1 CDS SP70585_1239 NC_012468.1 1153048 1153884 R identified by match to protein family HMM PF00874; match to protein family HMM PF03123; transcription antiterminator LacT complement(1153048..1153884) Streptococcus pneumoniae 70585 7684026 YP_002740485.1 CDS lacD NC_012468.1 1154118 1155098 R catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in Streptococcus pyogenes there are two paralogs of tagatose-bisphosphate aldolase, encoded by lacD1 and lacD2; expression of lacD1 is highly regulated by environmental conditions while lacD2 specializes in an efficient utilization of carbohydrate sources; tagatose 1,6-diphosphate aldolase complement(1154118..1155098) Streptococcus pneumoniae 70585 7684238 YP_002740486.1 CDS lacC NC_012468.1 1155100 1156029 R catalyzes the formation of tagatose 1,6-bisphosphate from tagatose 6-phosphate and ATP; tagatose-6-phosphate kinase complement(1155100..1156029) Streptococcus pneumoniae 70585 7683262 YP_002740487.1 CDS lacB NC_012468.1 1156040 1156555 R catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; galactose-6-phosphate isomerase subunit LacB complement(1156040..1156555) Streptococcus pneumoniae 70585 7683690 YP_002740488.1 CDS lacA NC_012468.1 1156586 1157011 R catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; tagatose pathway for galactose utilization; galactose-6-phosphate isomerase subunit LacA complement(1156586..1157011) Streptococcus pneumoniae 70585 7682913 YP_002740489.1 CDS SP70585_1244 NC_012468.1 1157168 1157512 R identified by glimmer; putative; hypothetical protein complement(1157168..1157512) Streptococcus pneumoniae 70585 7685010 YP_002740490.1 CDS SP70585_1245 NC_012468.1 1157681 1158061 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; mobile genetic element complement(1157681..1158061) Streptococcus pneumoniae 70585 7684699 YP_002740491.1 CDS SP70585_1246 NC_012468.1 1158068 1158466 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; mobile genetic element complement(1158068..1158466) Streptococcus pneumoniae 70585 7684397 YP_002740492.1 CDS SP70585_1247 NC_012468.1 1158474 1158776 R PTS system, galactose-specific IIB component complement(1158474..1158776) Streptococcus pneumoniae 70585 7684678 YP_002740493.1 CDS SP70585_1248 NC_012468.1 1158814 1159203 R phosphotransferase system sugar-specific EII component complement(1158814..1159203) Streptococcus pneumoniae 70585 7683120 YP_002740494.1 CDS SP70585_1249 NC_012468.1 1159470 1159802 D chlorohydrolase 1159470..1159802 Streptococcus pneumoniae 70585 7684608 YP_002740495.1 CDS lepA NC_012468.1 1159883 1161706 R binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA complement(1159883..1161706) Streptococcus pneumoniae 70585 7682908 YP_002740496.1 CDS SP70585_1251 NC_012468.1 1161785 1162513 R identified by match to protein family HMM PF00149; serine/threonine protein phosphatase complement(1161785..1162513) Streptococcus pneumoniae 70585 7683244 YP_002740497.1 CDS recN NC_012468.1 1162515 1164182 R identified by match to protein family HMM PF02463; match to protein family HMM TIGR00634; DNA repair protein RecN complement(1162515..1164182) Streptococcus pneumoniae 70585 7683558 YP_002740498.1 CDS SP70585_1253 NC_012468.1 1164189 1164620 R identified by match to protein family HMM PF01316; match to protein family HMM PF02863; transcriptional regulator of arginine metabolism expression complement(1164189..1164620) Streptococcus pneumoniae 70585 7684512 YP_002740499.1 CDS tylA NC_012468.1 1164613 1165428 R identified by match to protein family HMM PF01479; match to protein family HMM PF01728; match to protein family HMM TIGR00478; hemolysin A complement(1164613..1165428) Streptococcus pneumoniae 70585 7685094 YP_002740500.1 CDS SP70585_1255 NC_012468.1 1165421 1166296 R identified by match to protein family HMM PF00348; geranyltranstransferase (Farnesyl-diphosphate synthase)(FPP synthase) complement(1165421..1166296) Streptococcus pneumoniae 70585 7684167 YP_002740501.1 CDS xseB NC_012468.1 1166293 1166505 R catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit complement(1166293..1166505) Streptococcus pneumoniae 70585 7684499 YP_002740502.1 CDS xseA NC_012468.1 1166483 1167823 R bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit complement(1166483..1167823) Streptococcus pneumoniae 70585 7684433 YP_002740503.1 CDS udk NC_012468.1 1167951 1168589 R functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase complement(1167951..1168589) Streptococcus pneumoniae 70585 7682924 YP_002740504.1 CDS SP70585_1259 NC_012468.1 1168697 1168999 R hypothetical protein complement(1168697..1168999) Streptococcus pneumoniae 70585 7683841 YP_002740505.1 CDS truB NC_012468.1 1169240 1170118 R catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B complement(1169240..1170118) Streptococcus pneumoniae 70585 7683483 YP_002740506.1 CDS SP70585_1261 NC_012468.1 1170128 1171402 R hypothetical protein complement(1170128..1171402) Streptococcus pneumoniae 70585 7683207 YP_002740507.1 CDS SP70585_1262 NC_012468.1 1171573 1172613 R identified by match to protein family HMM PF01053; match to protein family HMM PF01212; O-acetylhomoserine (thiol)-lyase (O-acetylhomoserinesulfhydrylase) (OAH sulfhydrylase) (Homocysteine synthase) complement(1171573..1172613) Streptococcus pneumoniae 70585 7683253 YP_002740508.1 CDS SP70585_1263 NC_012468.1 1172635 1172757 R O-acetylhomoserine sulfhydrylase complement(1172635..1172757) Streptococcus pneumoniae 70585 7683099 YP_002740509.1 CDS SP70585_1264 NC_012468.1 1172905 1173702 R identified by match to protein family HMM PF01226; formate-nitrate transporter complement(1172905..1173702) Streptococcus pneumoniae 70585 7683826 YP_002740510.1 CDS SP70585_1265 NC_012468.1 1173946 1174689 R identified by match to protein family HMM PF04203; match to protein family HMM TIGR01076; sortase complement(1173946..1174689) Streptococcus pneumoniae 70585 7685021 YP_002740511.1 CDS gyrA NC_012468.1 1174689 1177157 R negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A complement(1174689..1177157) Streptococcus pneumoniae 70585 7684123 YP_002740512.1 CDS ldh NC_012468.1 1177351 1178337 D Converts (S)-lactate and NAD(+) to pyruvate and NADH; L-lactate dehydrogenase 1177351..1178337 Streptococcus pneumoniae 70585 7683501 YP_002740513.1 CDS SP70585_1268 NC_012468.1 1178597 1179370 R identified by match to protein family HMM PF00520; match to protein family HMM PF07885; potassium/ion channel protein complement(1178597..1179370) Streptococcus pneumoniae 70585 7683373 YP_002740514.1 CDS SP70585_1269 NC_012468.1 1179417 1179671 R identified by match to protein family HMM PF05016; match to protein family HMM TIGR02385; cytotoxic translational repressor of toxin-antitoxin stability system complement(1179417..1179671) Streptococcus pneumoniae 70585 7683097 YP_002740515.1 CDS SP70585_1270 NC_012468.1 1179673 1179915 R hypothetical protein complement(1179673..1179915) Streptococcus pneumoniae 70585 7683291 YP_002740516.1 CDS SP70585_1271 NC_012468.1 1180006 1180815 R identified by match to protein family HMM PF00753; VicX protein complement(1180006..1180815) Streptococcus pneumoniae 70585 7682919 YP_002740517.1 CDS SP70585_1272 NC_012468.1 1180817 1182166 R identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF00989; match to protein family HMM PF02518; match to protein family HMM TIGR00229; sensor protein YycG complement(1180817..1182166) Streptococcus pneumoniae 70585 7683471 YP_002740518.1 CDS SP70585_1273 NC_012468.1 1182159 1182863 R identified by match to protein family HMM PF00072; match to protein family HMM PF00486; alkaline phosphatase synthesis transcriptional regulatory proteinphoP complement(1182159..1182863) Streptococcus pneumoniae 70585 7684712 YP_002740519.1 CDS mutY NC_012468.1 1182918 1184093 R identified by match to protein family HMM PF00633; match to protein family HMM PF00730; match to protein family HMM TIGR01084; A/G-specific adenine glycosylase complement(1182918..1184093) Streptococcus pneumoniae 70585 7685069 YP_002740520.1 CDS fhs NC_012468.1 1184421 1186091 R catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate; formate--tetrahydrofolate ligase complement(1184421..1186091) Streptococcus pneumoniae 70585 7683155 YP_002740521.1 CDS coaB NC_012468.1 1186321 1187010 D identified by match to protein family HMM PF04127; match to protein family HMM TIGR02114; phosphopantothenate--cysteine ligase 1186321..1187010 Streptococcus pneumoniae 70585 7683646 YP_002740522.1 CDS coaC NC_012468.1 1187022 1187573 D decarboxylates 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine.; phosphopantothenoylcysteine decarboxylase 1187022..1187573 Streptococcus pneumoniae 70585 7684867 YP_002740523.1 CDS SP70585_1278 NC_012468.1 1187557 1188120 D integral membrane protein 1187557..1188120 Streptococcus pneumoniae 70585 7684419 YP_002740524.1 CDS SP70585_1279 NC_012468.1 1188402 1188929 D hypothetical protein 1188402..1188929 Streptococcus pneumoniae 70585 7684560 YP_002740525.1 CDS SP70585_1281 NC_012468.1 1188941 1189456 D identified by match to protein family HMM PF02829; match to protein family HMM PF08279; transcriptional regulator, biotin repressor family 1188941..1189456 Streptococcus pneumoniae 70585 7683002 YP_002740526.1 CDS SP70585_1280 NC_012468.1 1189453 1189593 R hypothetical protein complement(1189453..1189593) Streptococcus pneumoniae 70585 7684633 YP_002740527.1 CDS SP70585_1282 NC_012468.1 1189646 1189831 D IS66 family element 1189646..1189831 Streptococcus pneumoniae 70585 7684719 YP_002740528.1 CDS SP70585_1283 NC_012468.1 1189812 1190135 D identified by match to protein family HMM PF05717; IS66 family element, Orf2 1189812..1190135 Streptococcus pneumoniae 70585 7683688 YP_002740529.1 CDS SP70585_1284 NC_012468.1 1190290 1190556 R transposase family protein complement(1190290..1190556) Streptococcus pneumoniae 70585 7684580 YP_002740530.1 CDS SP70585_1288 NC_012468.1 1191790 1192251 R transposase complement(1191790..1192251) Streptococcus pneumoniae 70585 7683172 YP_002740531.1 CDS SP70585_1289 NC_012468.1 1192633 1193730 R identified by match to protein family HMM PF00512; match to protein family HMM PF02518; NisK complement(1192633..1193730) Streptococcus pneumoniae 70585 7684113 YP_002740532.1 CDS SP70585_1290 NC_012468.1 1193715 1194398 R identified by match to protein family HMM PF00072; match to protein family HMM PF00486; NisR complement(1193715..1194398) Streptococcus pneumoniae 70585 7685006 YP_002740533.1 CDS SP70585_1291 NC_012468.1 1194429 1195136 R hypothetical protein complement(1194429..1195136) Streptococcus pneumoniae 70585 7685114 YP_002740534.1 CDS SP70585_1292 NC_012468.1 1195133 1195924 R hypothetical protein complement(1195133..1195924) Streptococcus pneumoniae 70585 7682886 YP_002740535.1 CDS SP70585_1293 NC_012468.1 1195914 1196630 R identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein complement(1195914..1196630) Streptococcus pneumoniae 70585 7684610 YP_002740536.1 CDS SP70585_1294 NC_012468.1 1196643 1198865 R identified by match to protein family HMM PF00005; match to protein family HMM PF00664; ABC transporter NBP/MSD fusion protein complement(1196643..1198865) Streptococcus pneumoniae 70585 7684446 YP_002740537.1 CDS SP70585_1295 NC_012468.1 1198869 1199120 R identified by glimmer; putative; hypothetical protein complement(1198869..1199120) Streptococcus pneumoniae 70585 7684752 YP_002740538.1 CDS SP70585_1296 NC_012468.1 1199135 1200859 R identified by match to protein family HMM PF00733; putative asparagine synthetase complement(1199135..1200859) Streptococcus pneumoniae 70585 7683096 YP_002740539.1 CDS SP70585_1297 NC_012468.1 1200976 1201104 R identified by glimmer; putative; hypothetical protein complement(1200976..1201104) Streptococcus pneumoniae 70585 7684881 YP_002740540.1 CDS SP70585_1298 NC_012468.1 1201830 1202102 R NTP pyrophosphohydrolase including oxidative damage repair enzymes complement(1201830..1202102) Streptococcus pneumoniae 70585 7684142 YP_002740541.1 CDS SP70585_1299 NC_012468.1 1202347 1202856 R identified by match to protein family HMM PF00583; acetyltransferase, gnat family complement(1202347..1202856) Streptococcus pneumoniae 70585 7683961 YP_002740542.1 CDS SP70585_1300 NC_012468.1 1202822 1203385 R acetyltransferase, gnat family complement(1202822..1203385) Streptococcus pneumoniae 70585 7683997 YP_002740543.1 CDS uvrB NC_012468.1 1203395 1205383 R The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B complement(1203395..1205383) Streptococcus pneumoniae 70585 7684059 YP_002740544.1 CDS SP70585_1302 NC_012468.1 1205460 1206413 R identified by match to protein family HMM PF02517; caax amino protease family complement(1205460..1206413) Streptococcus pneumoniae 70585 7683044 YP_002740545.1 CDS SP70585_1303 NC_012468.1 1206585 1208750 D identified by match to protein family HMM PF00497; match to protein family HMM PF00528; match to protein family HMM TIGR01726; amino acid ABC transporter permease/substrate-binding protein 1206585..1208750 Streptococcus pneumoniae 70585 7683491 YP_002740546.1 CDS SP70585_1304 NC_012468.1 1208750 1209490 D identified by match to protein family HMM PF00005; glutamine transport ATP-binding protein GlnQ 1208750..1209490 Streptococcus pneumoniae 70585 7684834 YP_002740547.1 CDS zwf NC_012468.1 1209639 1211126 D catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 1209639..1211126 Streptococcus pneumoniae 70585 7682904 YP_002740548.1 CDS SP70585_1306 NC_012468.1 1211170 1212447 R identified by match to protein family HMM PF00448; match to protein family HMM PF02881; match to protein family HMM TIGR00064; cell division protein FtsY complement(1211170..1212447) Streptococcus pneumoniae 70585 7683426 YP_002740549.1 CDS SP70585_1307 NC_012468.1 1212451 1213269 R identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; Cof family protein complement(1212451..1213269) Streptococcus pneumoniae 70585 7683607 YP_002740550.1 CDS SP70585_1308 NC_012468.1 1213269 1214063 R identified by match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; Cof family protein complement(1213269..1214063) Streptococcus pneumoniae 70585 7683166 YP_002740551.1 CDS smc NC_012468.1 1214060 1217599 R identified by match to protein family HMM PF02463; match to protein family HMM PF06470; match to protein family HMM TIGR02168; chromosome segregation protein SMC complement(1214060..1217599) Streptococcus pneumoniae 70585 7683009 YP_002740552.1 CDS rnc NC_012468.1 1217590 1218288 R cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III complement(1217590..1218288) Streptococcus pneumoniae 70585 7684959 YP_002740553.1 CDS guaC NC_012468.1 1218606 1219592 R identified by match to protein family HMM PF00478; match to protein family HMM TIGR01306; guanosine 5'-monophosphate oxidoreductase complement(1218606..1219592) Streptococcus pneumoniae 70585 7683902 YP_002740554.1 CDS SP70585_1313 NC_012468.1 1219767 1221083 R hypothetical protein complement(1219767..1221083) Streptococcus pneumoniae 70585 7683395 YP_002740555.1 CDS SP70585_1314 NC_012468.1 1221070 1223001 R hypothetical protein complement(1221070..1223001) Streptococcus pneumoniae 70585 7683749 YP_002740556.1 CDS SP70585_1315 NC_012468.1 1223164 1223325 R identified by glimmer; putative; hypothetical protein complement(1223164..1223325) Streptococcus pneumoniae 70585 7685066 YP_002740557.1 CDS SP70585_1316 NC_012468.1 1223315 1223488 R identified by glimmer; putative; hypothetical protein complement(1223315..1223488) Streptococcus pneumoniae 70585 7684530 YP_002740558.1 CDS SP70585_1317 NC_012468.1 1223588 1223731 R identified by glimmer; putative; hypothetical protein complement(1223588..1223731) Streptococcus pneumoniae 70585 7683678 YP_002740559.1 CDS SP70585_1318 NC_012468.1 1223950 1224309 R hypothetical protein complement(1223950..1224309) Streptococcus pneumoniae 70585 7683584 YP_002740560.1 CDS SP70585_1319 NC_012468.1 1224313 1224582 R identified by match to protein family HMM PF06961; hypothetical protein complement(1224313..1224582) Streptococcus pneumoniae 70585 7684935 YP_002740561.1 CDS leuB NC_012468.1 1224579 1225616 R catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase complement(1224579..1225616) Streptococcus pneumoniae 70585 7683797 YP_002740562.1 CDS SP70585_1321 NC_012468.1 1225628 1226062 R identified by match to protein family HMM PF08502; 2-isopropylmalate synthase (Alpha-isopropylmalatesynthase) (Alpha-IPM synthetase) complement(1225628..1226062) Streptococcus pneumoniae 70585 7683007 YP_002740563.1 CDS SP70585_1322 NC_012468.1 1226090 1226722 R identified by match to protein family HMM PF00682; 2-isopropylmalate synthase (Alpha-isopropylmalatesynthase) (Alpha-IPM synthetase) complement(1226090..1226722) Streptococcus pneumoniae 70585 7683673 YP_002740564.1 CDS SP70585_1323 NC_012468.1 1226741 1227397 R identified by match to protein family HMM PF04237; hypothetical protein complement(1226741..1227397) Streptococcus pneumoniae 70585 7684786 YP_002740565.1 CDS SP70585_1324 NC_012468.1 1227441 1228073 R identified by match to protein family HMM PF03932; copper homeostasis protein CutC complement(1227441..1228073) Streptococcus pneumoniae 70585 7683462 YP_002740566.1 CDS SP70585_1325 NC_012468.1 1228166 1228525 R identified by match to protein family HMM PF04304; hypothetical protein complement(1228166..1228525) Streptococcus pneumoniae 70585 7683627 YP_002740567.1 CDS topA NC_012468.1 1228631 1230718 R catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I complement(1228631..1230718) Streptococcus pneumoniae 70585 7684363 YP_002740568.1 CDS SP70585_1327 NC_012468.1 1230885 1231928 R identified by match to protein family HMM PF04087; hypothetical protein complement(1230885..1231928) Streptococcus pneumoniae 70585 7683092 YP_002740569.1 CDS SP70585_1328 NC_012468.1 1232506 1232628 D chlorohydrolase 1232506..1232628 Streptococcus pneumoniae 70585 7685166 YP_002740570.1 CDS dprA NC_012468.1 1232812 1233660 R identified by match to protein family HMM PF02481; match to protein family HMM TIGR00732; DNA protecting protein DprA complement(1232812..1233660) Streptococcus pneumoniae 70585 7683427 YP_002740571.1 CDS SP70585_1330 NC_012468.1 1233756 1234445 R identified by match to protein family HMM PF00483; LPS epitope expression regulatory protein complement(1233756..1234445) Streptococcus pneumoniae 70585 7683016 YP_002740572.1 CDS SP70585_1331 NC_012468.1 1234457 1235335 R identified by match to protein family HMM PF00892; LPS epitope expression regulatory protein complement(1234457..1235335) Streptococcus pneumoniae 70585 7684809 YP_002740573.1 CDS SP70585_1332 NC_012468.1 1235325 1236194 R identified by match to protein family HMM PF01633; match to protein family HMM PF01636; choline kinase complement(1235325..1236194) Streptococcus pneumoniae 70585 7683880 YP_002740574.1 CDS SP70585_1333 NC_012468.1 1236211 1237233 R identified by match to protein family HMM PF08240; xylitol dehydrogenase complement(1236211..1237233) Streptococcus pneumoniae 70585 7684872 YP_002740575.1 CDS ispD NC_012468.1 1237238 1237945 R 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase complement(1237238..1237945) Streptococcus pneumoniae 70585 7684462 YP_002740576.1 CDS SP70585_1335 NC_012468.1 1238281 1239768 D identified by match to protein family HMM PF01943; match to protein family HMM PF03023; virulence factor mvin superfamily 1238281..1239768 Streptococcus pneumoniae 70585 7683506 YP_002740577.1 CDS SP70585_1336 NC_012468.1 1239778 1240581 D required for phosphorylcholine incorporation in teichoic and lipoteichoic acids; identified by match to protein family HMM PF04991; phosphotransferase 1239778..1240581 Streptococcus pneumoniae 70585 7684936 YP_002740578.1 CDS SP70585_1337 NC_012468.1 1240583 1241392 D identified by match to protein family HMM PF04991; LicD Protein 1240583..1241392 Streptococcus pneumoniae 70585 7685154 YP_002740579.1 CDS carB NC_012468.1 1241667 1244843 R four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit complement(1241667..1244843) Streptococcus pneumoniae 70585 7684237 YP_002740580.1 CDS carA NC_012468.1 1245155 1246234 R catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit complement(1245155..1246234) Streptococcus pneumoniae 70585 7684083 YP_002740581.1 CDS pyrB NC_012468.1 1246284 1247207 R catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase catalytic subunit complement(1246284..1247207) Streptococcus pneumoniae 70585 7684493 YP_002740582.1 CDS SP70585_1341 NC_012468.1 1247226 1247747 R regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity; bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase complement(1247226..1247747) Streptococcus pneumoniae 70585 7683495 YP_002740583.1 CDS nth NC_012468.1 1247958 1248587 R identified by match to protein family HMM PF00633; match to protein family HMM PF00730; match to protein family HMM TIGR01083; endonuclease III complement(1247958..1248587) Streptococcus pneumoniae 70585 7684365 YP_002740584.1 CDS SP70585_1343 NC_012468.1 1248587 1249129 R identified by match to protein family HMM PF02620; hypothetical protein complement(1248587..1249129) Streptococcus pneumoniae 70585 7682938 YP_002740585.1 CDS SP70585_1344 NC_012468.1 1249299 1249616 D BlpT protein, fusion 1249299..1249616 Streptococcus pneumoniae 70585 7684589 YP_002740586.1 CDS SP70585_1345 NC_012468.1 1249855 1251414 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1249855..1251414 Streptococcus pneumoniae 70585 7684407 YP_002740587.1 CDS SP70585_1346 NC_012468.1 1251451 1251978 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase complement(1251451..1251978) Streptococcus pneumoniae 70585 7684065 YP_002740588.1 CDS SP70585_1347 NC_012468.1 1251975 1252757 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01610; transposase complement(1251975..1252757) Streptococcus pneumoniae 70585 7684358 YP_002740589.1 CDS SP70585_1348 NC_012468.1 1253035 1253934 R putative metalloprotease; heat shock protein HtpX complement(1253035..1253934) Streptococcus pneumoniae 70585 7684665 YP_002740590.1 CDS SP70585_1349 NC_012468.1 1253936 1254496 R identified by match to protein family HMM PF04011; cytoplasmic membrane protein complement(1253936..1254496) Streptococcus pneumoniae 70585 7683691 YP_002740591.1 CDS gidB NC_012468.1 1254590 1255303 D glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 1254590..1255303 Streptococcus pneumoniae 70585 7684952 YP_002740592.1 CDS SP70585_1351 NC_012468.1 1255557 1256840 D identified by match to protein family HMM PF00860; match to protein family HMM TIGR00801; uracil permease (Uracil transporter) 1255557..1256840 Streptococcus pneumoniae 70585 7682930 YP_002740593.1 CDS ffh NC_012468.1 1257035 1258606 R identified by match to protein family HMM PF00448; match to protein family HMM PF02881; match to protein family HMM PF02978; match to protein family HMM TIGR00959; signal recognition particle protein complement(1257035..1258606) Streptococcus pneumoniae 70585 7683697 YP_002740594.1 CDS SP70585_1353 NC_012468.1 1258618 1258950 R identified by match to protein family HMM PF04297; match to protein family HMM PF04967; match to protein family HMM PF08281; putative DNA-binding protein complement(1258618..1258950) Streptococcus pneumoniae 70585 7683103 YP_002740595.1 CDS SP70585_1354 NC_012468.1 1259040 1259417 R identified by match to protein family HMM PF09148; hypothetical protein complement(1259040..1259417) Streptococcus pneumoniae 70585 7683290 YP_002740596.1 CDS SP70585_1355 NC_012468.1 1259393 1260793 D identified by match to protein family HMM PF01966; dGTP triphosphohydrolase 1259393..1260793 Streptococcus pneumoniae 70585 7685075 YP_002740597.1 CDS SP70585_1356 NC_012468.1 1260806 1261612 D identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; phosphatase YidA 1260806..1261612 Streptococcus pneumoniae 70585 7684609 YP_002740598.1 CDS rplS NC_012468.1 1261782 1262129 R this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 complement(1261782..1262129) Streptococcus pneumoniae 70585 7683898 YP_002740599.1 CDS SP70585_1359 NC_012468.1 1262248 1262577 R may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB complement(1262248..1262577) Streptococcus pneumoniae 70585 7683667 YP_002740600.1 CDS SP70585_1360 NC_012468.1 1262571 1262945 R may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB complement(1262571..1262945) Streptococcus pneumoniae 70585 7684385 YP_002740601.1 CDS SP70585_1361 NC_012468.1 1262942 1263208 R identified by match to protein family HMM PF01817; match to protein family HMM TIGR01805; hypothetical protein complement(1262942..1263208) Streptococcus pneumoniae 70585 7683071 YP_002740602.1 CDS SP70585_1362 NC_012468.1 1263324 1263767 R An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin complement(1263324..1263767) Streptococcus pneumoniae 70585 7683811 YP_002740603.1 CDS SP70585_1363 NC_012468.1 1263871 1264806 D identified by match to protein family HMM PF01368; match to protein family HMM PF02272; DHH subfamily 1 protein 1263871..1264806 Streptococcus pneumoniae 70585 7682917 YP_002740604.1 CDS rpmE2 NC_012468.1 1264902 1265144 D RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 type B 1264902..1265144 Streptococcus pneumoniae 70585 7683681 YP_002740605.1 CDS SP70585_1365 NC_012468.1 1265201 1265419 R high-affinity Fe2+/Pb2+ permease complement(1265201..1265419) Streptococcus pneumoniae 70585 7683457 YP_002740606.1 CDS SP70585_1368 NC_012468.1 1265956 1266360 R transposase complement(1265956..1266360) Streptococcus pneumoniae 70585 7684880 YP_002740607.1 CDS SP70585_1369 NC_012468.1 1266908 1268254 D converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; glutamate dehydrogenase 1266908..1268254 Streptococcus pneumoniae 70585 7683335 YP_002740608.1 CDS SP70585_1370 NC_012468.1 1268760 1268930 R hypothetical protein complement(1268760..1268930) Streptococcus pneumoniae 70585 7683891 YP_002740609.1 CDS SP70585_1371 NC_012468.1 1268943 1269584 R identified by match to protein family HMM PF00005; multidrug resistance protein 1 (ATP-binding cassettesub-family B member 1) (P-glycoprotein 1) (antigen) complement(1268943..1269584) Streptococcus pneumoniae 70585 7684074 YP_002740610.1 CDS SP70585_1372 NC_012468.1 1269857 1270453 D an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase 1269857..1270453 Streptococcus pneumoniae 70585 7683643 YP_002740611.1 CDS SP70585_1373 NC_012468.1 1270603 1270806 R glucokinase complement(1270603..1270806) Streptococcus pneumoniae 70585 7683446 YP_002740612.1 CDS SP70585_1374 NC_012468.1 1270824 1271741 R identified by match to protein family HMM PF00701; N-acetylneuraminate lyase complement(1270824..1271741) Streptococcus pneumoniae 70585 7683570 YP_002740613.1 CDS cdd2 NC_012468.1 1271773 1272180 R identified by match to protein family HMM PF00383; match to protein family HMM TIGR01354; cytidine deaminase complement(1271773..1272180) Streptococcus pneumoniae 70585 7684810 YP_002740614.1 CDS pgpA NC_012468.1 1272468 1272956 R identified by match to protein family HMM PF04608; phosphatidylglycerophosphatase A complement(1272468..1272956) Streptococcus pneumoniae 70585 7684533 YP_002740615.1 CDS SP70585_1377 NC_012468.1 1272961 1274370 R hypothetical protein complement(1272961..1274370) Streptococcus pneumoniae 70585 7684745 YP_002740616.1 CDS SP70585_1378 NC_012468.1 1274380 1275939 R identified by match to protein family HMM PF00005; match to protein family HMM PF08352; match to protein family HMM TIGR01727; glutathione import ATP-binding protein GsiA complement(1274380..1275939) Streptococcus pneumoniae 70585 7685027 YP_002740617.1 CDS SP70585_1379 NC_012468.1 1276261 1276398 R hypothetical protein complement(1276261..1276398) Streptococcus pneumoniae 70585 7684009 YP_002740618.1 CDS SP70585_1380 NC_012468.1 1276532 1277851 R hypothetical protein complement(1276532..1277851) Streptococcus pneumoniae 70585 7684626 YP_002740619.1 CDS SP70585_1381 NC_012468.1 1277854 1278594 R identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein complement(1277854..1278594) Streptococcus pneumoniae 70585 7683777 YP_002740620.1 CDS SP70585_1382 NC_012468.1 1278609 1280216 R identified by match to protein family HMM PF00005; match to protein family HMM PF00664; drug efflux ABC transporter ATP-binding/permease protein complement(1278609..1280216) Streptococcus pneumoniae 70585 7683220 YP_002740621.1 CDS SP70585_1383 NC_012468.1 1280213 1282153 R identified by match to protein family HMM PF00326; prolyl oligopeptidase family protein complement(1280213..1282153) Streptococcus pneumoniae 70585 7683830 YP_002740622.1 CDS SP70585_1384 NC_012468.1 1282186 1284795 R identified by match to protein family HMM PF05147; hypothetical protein complement(1282186..1284795) Streptococcus pneumoniae 70585 7683359 YP_002740623.1 CDS SP70585_1385 NC_012468.1 1284974 1285111 R hypothetical protein complement(1284974..1285111) Streptococcus pneumoniae 70585 7684473 YP_002740624.1 CDS SP70585_1386 NC_012468.1 1285313 1285900 R identified by match to protein family HMM PF02517; caax amino protease family complement(1285313..1285900) Streptococcus pneumoniae 70585 7684898 YP_002740625.1 CDS SP70585_1387 NC_012468.1 1285993 1286136 R hypothetical protein complement(1285993..1286136) Streptococcus pneumoniae 70585 7683047 YP_002740626.1 CDS SP70585_1388 NC_012468.1 1286149 1286529 R hypothetical protein complement(1286149..1286529) Streptococcus pneumoniae 70585 7683945 YP_002740627.1 CDS SP70585_1389 NC_012468.1 1286522 1286773 R hypothetical protein complement(1286522..1286773) Streptococcus pneumoniae 70585 7683545 YP_002740628.1 CDS SP70585_1390 NC_012468.1 1286853 1287017 R identified by match to protein family HMM PF06970; replication intiation protein complement(1286853..1287017) Streptococcus pneumoniae 70585 7684193 YP_002740629.1 CDS SP70585_1391 NC_012468.1 1287107 1287229 R hypothetical protein complement(1287107..1287229) Streptococcus pneumoniae 70585 7684887 YP_002740630.1 CDS rplL NC_012468.1 1287476 1287844 R present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 complement(1287476..1287844) Streptococcus pneumoniae 70585 7684427 YP_002740631.1 CDS rplJ NC_012468.1 1287920 1288420 R binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 complement(1287920..1288420) Streptococcus pneumoniae 70585 7684482 YP_002740632.1 CDS SP70585_1394 NC_012468.1 1288425 1288574 D identified by glimmer; putative; hypothetical protein 1288425..1288574 Streptococcus pneumoniae 70585 7685188 YP_002740633.1 CDS SP70585_1395 NC_012468.1 1288669 1289928 R identified by match to protein family HMM PF01979; match to protein family HMM PF07969; chlorohydrolase complement(1288669..1289928) Streptococcus pneumoniae 70585 7685142 YP_002740634.1 CDS SP70585_1396 NC_012468.1 1290230 1291978 R identified by match to protein family HMM PF00005; match to protein family HMM PF00664; ABC transporter ATP-binding protein/permease complement(1290230..1291978) Streptococcus pneumoniae 70585 7684578 YP_002740635.1 CDS SP70585_1397 NC_012468.1 1291980 1293704 R identified by match to protein family HMM PF00005; match to protein family HMM PF00664; ABC transporter ATP-binding protein/permease complement(1291980..1293704) Streptococcus pneumoniae 70585 7684631 YP_002740636.1 CDS SP70585_1398 NC_012468.1 1293762 1294700 R identified by match to protein family HMM PF01625; match to protein family HMM PF01641; match to protein family HMM TIGR00357; match to protein family HMM TIGR00401; peptide methionine sulfoxide reductase MsrA/msrB complement(1293762..1294700) Streptococcus pneumoniae 70585 7684723 YP_002740637.1 CDS thrB NC_012468.1 1294995 1295864 R catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase complement(1294995..1295864) Streptococcus pneumoniae 70585 7685085 YP_002740638.1 CDS SP70585_1400 NC_012468.1 1295866 1297152 R catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine; homoserine dehydrogenase complement(1295866..1297152) Streptococcus pneumoniae 70585 7685025 YP_002740639.1 CDS SP70585_1401 NC_012468.1 1297303 1298040 R enables recognition and targeting of proteins for proteolysis, involved in negative regulation of competence; adaptor protein complement(1297303..1298040) Streptococcus pneumoniae 70585 7684096 YP_002740640.1 CDS SP70585_1402 NC_012468.1 1298240 1299274 R hypothetical protein complement(1298240..1299274) Streptococcus pneumoniae 70585 7683408 YP_002740641.1 CDS SP70585_1403 NC_012468.1 1299303 1300736 R hypothetical protein complement(1299303..1300736) Streptococcus pneumoniae 70585 7682935 YP_002740642.1 CDS SP70585_1404 NC_012468.1 1300752 1301738 R identified by match to protein family HMM PF00535; galactosyl transferase complement(1300752..1301738) Streptococcus pneumoniae 70585 7683294 YP_002740643.1 CDS SP70585_1405 NC_012468.1 1301740 1302840 R identified by match to protein family HMM PF00534; glycosyl transferase, group 1 family protein complement(1301740..1302840) Streptococcus pneumoniae 70585 7683498 YP_002740644.1 CDS SP70585_1406 NC_012468.1 1302833 1303678 R identified by match to protein family HMM PF04991; licD3 protein complement(1302833..1303678) Streptococcus pneumoniae 70585 7684064 YP_002740645.1 CDS SP70585_1407 NC_012468.1 1303957 1305231 R identified by match to protein family HMM PF03816; match to protein family HMM TIGR00350; transcriptional regulator, LytR family complement(1303957..1305231) Streptococcus pneumoniae 70585 7683117 YP_002740646.1 CDS SP70585_1408 NC_012468.1 1305228 1306076 R catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; prephenate dehydratase complement(1305228..1306076) Streptococcus pneumoniae 70585 7684663 YP_002740647.1 CDS aroK NC_012468.1 1306073 1306549 R identified by match to protein family HMM PF01202; shikimate kinase complement(1306073..1306549) Streptococcus pneumoniae 70585 7685113 YP_002740648.1 CDS aroA NC_012468.1 1306542 1307825 R catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase complement(1306542..1307825) Streptococcus pneumoniae 70585 7684465 YP_002740649.1 CDS SP70585_1411 NC_012468.1 1307917 1308255 R identified by match to protein family HMM PF06133; hypothetical protein complement(1307917..1308255) Streptococcus pneumoniae 70585 7683516 YP_002740650.1 CDS SP70585_1412 NC_012468.1 1308266 1309369 R catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate; prephenate dehydrogenase complement(1308266..1309369) Streptococcus pneumoniae 70585 7685073 YP_002740651.1 CDS aroC NC_012468.1 1309379 1310545 R catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase complement(1309379..1310545) Streptococcus pneumoniae 70585 7683665 YP_002740652.1 CDS aroB NC_012468.1 1310555 1311622 R catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase complement(1310555..1311622) Streptococcus pneumoniae 70585 7683055 YP_002740653.1 CDS aroE NC_012468.1 1311641 1312495 R AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase complement(1311641..1312495) Streptococcus pneumoniae 70585 7683129 YP_002740654.1 CDS aroD NC_012468.1 1312485 1313162 R catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis; 3-dehydroquinate dehydratase complement(1312485..1313162) Streptococcus pneumoniae 70585 7683034 YP_002740655.1 CDS SP70585_1417 NC_012468.1 1313159 1314322 R methyltransferase complement(1313159..1314322) Streptococcus pneumoniae 70585 7683144 YP_002740656.1 CDS SP70585_1418 NC_012468.1 1315007 1316641 R hypothetical protein complement(1315007..1316641) Streptococcus pneumoniae 70585 7684969 YP_002740657.1 CDS SP70585_1419 NC_012468.1 1316622 1317371 R identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein complement(1316622..1317371) Streptococcus pneumoniae 70585 7683700 YP_002740658.1 CDS SP70585_1420 NC_012468.1 1317550 1319004 D converts 1,4-alpha-D-glucans to maltodextrin; cytoplasmic alpha-amylase 1317550..1319004 Streptococcus pneumoniae 70585 7684360 YP_002740659.1 CDS alaS NC_012468.1 1319094 1321712 R Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase complement(1319094..1321712) Streptococcus pneumoniae 70585 7684267 YP_002740660.1 CDS SP70585_1422 NC_012468.1 1321734 1322219 R identified by match to protein family HMM PF04525; hypothetical protein complement(1321734..1322219) Streptococcus pneumoniae 70585 7684622 YP_002740661.1 CDS SP70585_1423 NC_012468.1 1322494 1322733 R hypothetical protein complement(1322494..1322733) Streptococcus pneumoniae 70585 7684024 YP_002740662.1 CDS SP70585_1424 NC_012468.1 1322994 1324064 R identified by match to protein family HMM PF01547; spermidine/putrescine ABC transporter spermidine/putrescine-binding protein complement(1322994..1324064) Streptococcus pneumoniae 70585 7685161 YP_002740663.1 CDS SP70585_1425 NC_012468.1 1324061 1324834 R identified by match to protein family HMM PF00528; spermidine/putrescine ABC transporter permease complement(1324061..1324834) Streptococcus pneumoniae 70585 7684129 YP_002740664.1 CDS SP70585_1426 NC_012468.1 1324831 1325637 R identified by match to protein family HMM PF00528; spermidine/putrescine ABC transporter permease complement(1324831..1325637) Streptococcus pneumoniae 70585 7684588 YP_002740665.1 CDS SP70585_1427 NC_012468.1 1325618 1326775 R identified by match to protein family HMM PF00005; match to protein family HMM PF08402; spermidine/putrescine import ATP-binding protein PotA complement(1325618..1326775) Streptococcus pneumoniae 70585 7683819 YP_002740666.1 CDS murB NC_012468.1 1326936 1327841 R catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase complement(1326936..1327841) Streptococcus pneumoniae 70585 7683323 YP_002740667.1 CDS budA NC_012468.1 1328715 1329446 R identified by match to protein family HMM PF03306; match to protein family HMM TIGR01252; alpha-acetolactate decarboxylase complement(1328715..1329446) Streptococcus pneumoniae 70585 7683218 YP_002740668.1 CDS SP70585_1432 NC_012468.1 1329588 1330859 D identified by match to protein family HMM PF00392; GntR family transcriptional regulator 1329588..1330859 Streptococcus pneumoniae 70585 7684693 YP_002740669.1 CDS SP70585_1433 NC_012468.1 1330879 1331694 R identified by match to protein family HMM PF00497; amino acid ABC transporter substrate-binding protein complement(1330879..1331694) Streptococcus pneumoniae 70585 7683137 YP_002740670.1 CDS phoU1 NC_012468.1 1331851 1332504 R identified by match to protein family HMM PF01895; match to protein family HMM TIGR02135; phosphate transport system regulatory protein PhoU complement(1331851..1332504) Streptococcus pneumoniae 70585 7685106 YP_002740671.1 CDS pstB1 NC_012468.1 1332516 1333274 R ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein complement(1332516..1333274) Streptococcus pneumoniae 70585 7684732 YP_002740672.1 CDS pstB2 NC_012468.1 1333287 1334090 R ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein complement(1333287..1334090) Streptococcus pneumoniae 70585 7683500 YP_002740673.1 CDS pstA1 NC_012468.1 1334101 1334985 R identified by match to protein family HMM PF00528; match to protein family HMM TIGR00974; phosphate ABC transporter permease complement(1334101..1334985) Streptococcus pneumoniae 70585 7684569 YP_002740674.1 CDS pstC1 NC_012468.1 1334975 1335892 R identified by match to protein family HMM PF00528; match to protein family HMM TIGR02138; phosphate ABC transporter permease complement(1334975..1335892) Streptococcus pneumoniae 70585 7684428 YP_002740675.1 CDS SP70585_1439 NC_012468.1 1335892 1336770 R identified by match to protein family HMM PF01547; match to protein family HMM TIGR02136; phosphate-binding protein PstS 1 (PBP 1) complement(1335892..1336770) Streptococcus pneumoniae 70585 7683328 YP_002740676.1 CDS SP70585_1440 NC_012468.1 1337000 1337113 D hypothetical protein 1337000..1337113 Streptococcus pneumoniae 70585 7683832 YP_002740677.1 CDS SP70585_1441 NC_012468.1 1337344 1338648 R identified by match to protein family HMM PF01189; NOL1/NOP2/sun family protein complement(1337344..1338648) Streptococcus pneumoniae 70585 7683523 YP_002740678.1 CDS SP70585_1442 NC_012468.1 1338649 1339422 R identified by match to protein family HMM PF00459; inositol monophosphatase family protein complement(1338649..1339422) Streptococcus pneumoniae 70585 7684463 YP_002740679.1 CDS SP70585_1443 NC_012468.1 1339412 1339690 R identified by match to protein family HMM PF05256; hypothetical protein complement(1339412..1339690) Streptococcus pneumoniae 70585 7683547 YP_002740680.1 CDS spxA NC_012468.1 1339690 1340091 R the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress; transcriptional regulator Spx complement(1339690..1340091) Streptococcus pneumoniae 70585 7684488 YP_002740681.1 CDS SP70585_1445 NC_012468.1 1340301 1340918 R identified by match to protein family HMM PF07314; match to protein family HMM TIGR01906; integral membrane protein complement(1340301..1340918) Streptococcus pneumoniae 70585 7682945 YP_002740682.1 CDS SP70585_1446 NC_012468.1 1340908 1341681 R identified by match to protein family HMM PF00702; match to protein family HMM TIGR01457; match to protein family HMM TIGR01460; HAD-superfamily subfamily IIA hydrolase complement(1340908..1341681) Streptococcus pneumoniae 70585 7684324 YP_002740683.1 CDS SP70585_1447 NC_012468.1 1341692 1342429 R identified by match to protein family HMM PF01643; acyl-ACP thioesterase complement(1341692..1342429) Streptococcus pneumoniae 70585 7683989 YP_002740684.1 CDS SP70585_1448 NC_012468.1 1342434 1343564 R catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase complement(1342434..1343564) Streptococcus pneumoniae 70585 7684127 YP_002740685.1 CDS SP70585_1449 NC_012468.1 1343648 1344037 R hypothetical protein complement(1343648..1344037) Streptococcus pneumoniae 70585 7684149 YP_002740686.1 CDS SP70585_1450 NC_012468.1 1344053 1344436 R identified by match to protein family HMM PF06103; hypothetical protein complement(1344053..1344436) Streptococcus pneumoniae 70585 7683079 YP_002740687.1 CDS lgt NC_012468.1 1344437 1345225 R transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase complement(1344437..1345225) Streptococcus pneumoniae 70585 7684688 YP_002740688.1 CDS hprK NC_012468.1 1345218 1346153 R catalyzes the phosphorylation of the phosphocarrier protein HPr of the bacterial phosphotransferase system; HPr kinase/phosphorylase complement(1345218..1346153) Streptococcus pneumoniae 70585 7683131 YP_002740689.1 CDS rpsU NC_012468.1 1346283 1346459 R a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 complement(1346283..1346459) Streptococcus pneumoniae 70585 7683285 YP_002740690.1 CDS SP70585_1454 NC_012468.1 1346599 1347306 R identified by match to protein family HMM PF01182; glucosamine-6-phosphate deaminase (glucosamine-6-phosphate isomerase) (gnpda) (glcn6p deaminase) complement(1346599..1347306) Streptococcus pneumoniae 70585 7682925 YP_002740691.1 CDS queA NC_012468.1 1347457 1348485 D Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine:tRNA ribosyltransferase-isomerase 1347457..1348485 Streptococcus pneumoniae 70585 7683626 YP_002740692.1 CDS SP70585_1456 NC_012468.1 1349146 1349535 R identified by match to protein family HMM PF01473; choline binding protein complement(1349146..1349535) Streptococcus pneumoniae 70585 7683475 YP_002740693.1 CDS SP70585_1457 NC_012468.1 1351004 1351555 R identified by match to protein family HMM PF00583; acetyltransferase, gnat family complement(1351004..1351555) Streptococcus pneumoniae 70585 7684235 YP_002740694.1 CDS nadE NC_012468.1 1351905 1352729 R catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase complement(1351905..1352729) Streptococcus pneumoniae 70585 7684673 YP_002740695.1 CDS pncB NC_012468.1 1352726 1354186 R catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase complement(1352726..1354186) Streptococcus pneumoniae 70585 7685063 YP_002740696.1 CDS SP70585_1460 NC_012468.1 1354302 1354790 R hypothetical protein complement(1354302..1354790) Streptococcus pneumoniae 70585 7684737 YP_002740697.1 CDS SP70585_1461 NC_012468.1 1354780 1354989 R identified by match to protein family HMM PF01381; hypothetical protein complement(1354780..1354989) Streptococcus pneumoniae 70585 7683581 YP_002740698.1 CDS SP70585_1462 NC_012468.1 1355375 1356103 R hypothetical protein complement(1355375..1356103) Streptococcus pneumoniae 70585 7684643 YP_002740699.1 CDS SP70585_1463 NC_012468.1 1356119 1356607 R multidrug ABC transporter ATP-binding protein complement(1356119..1356607) Streptococcus pneumoniae 70585 7684369 YP_002740700.1 CDS SP70585_1464 NC_012468.1 1356636 1357097 D an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase 1356636..1357097 Streptococcus pneumoniae 70585 7683766 YP_002740701.1 CDS SP70585_1466 NC_012468.1 1357109 1357486 D an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01609; transposase (IS4 family) 1357109..1357486 Streptococcus pneumoniae 70585 7683311 YP_002740702.1 CDS SP70585_1465 NC_012468.1 1357451 1357870 R ABC transporter ATP-binding protein complement(1357451..1357870) Streptococcus pneumoniae 70585 7683846 YP_002740703.1 CDS SP70585_1467 NC_012468.1 1358205 1358930 R identified by match to protein family HMM PF01136; peptidase, U32 family complement(1358205..1358930) Streptococcus pneumoniae 70585 7684750 YP_002740704.1 CDS SP70585_1468 NC_012468.1 1359101 1359250 D hypothetical protein 1359101..1359250 Streptococcus pneumoniae 70585 7682958 YP_002740705.1 CDS SP70585_1469 NC_012468.1 1359505 1360791 R identified by match to protein family HMM PF01136; peptidase, U32 family protein complement(1359505..1360791) Streptococcus pneumoniae 70585 7684102 YP_002740706.1 CDS SP70585_1470 NC_012468.1 1361415 1361597 D restriction endonuclease R.XbaI 1361415..1361597 Streptococcus pneumoniae 70585 7685122 YP_002740707.1 CDS SP70585_1471 NC_012468.1 1361781 1361972 D restriction endonuclease R.XbaI 1361781..1361972 Streptococcus pneumoniae 70585 7683072 YP_002740708.1 CDS SP70585_1472 NC_012468.1 1361969 1363159 D identified by match to protein family HMM PF01555; DNA modification methyltransferase M.XbaI 1361969..1363159 Streptococcus pneumoniae 70585 7684639 YP_002740709.1 CDS SP70585_1473 NC_012468.1 1363406 1363552 D hypothetical protein 1363406..1363552 Streptococcus pneumoniae 70585 7682879 YP_002740710.1 CDS SP70585_1474 NC_012468.1 1363674 1364666 R identified by match to protein family HMM PF00165; AraC family transcriptional regulator complement(1363674..1364666) Streptococcus pneumoniae 70585 7683360 YP_002740711.1 CDS SP70585_1475 NC_012468.1 1364826 1366580 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein/permease 1364826..1366580 Streptococcus pneumoniae 70585 7683474 YP_002740712.1 CDS SP70585_1476 NC_012468.1 1366564 1368318 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1366564..1368318 Streptococcus pneumoniae 70585 7684240 YP_002740713.1 CDS SP70585_1477 NC_012468.1 1368300 1368884 D identified by match to protein family HMM TIGR02185; hypothetical protein 1368300..1368884 Streptococcus pneumoniae 70585 7684903 YP_002740714.1 CDS SP70585_1478 NC_012468.1 1368884 1369579 D identified by match to protein family HMM PF02361; cobalt transport protein 1368884..1369579 Streptococcus pneumoniae 70585 7684780 YP_002740715.1 CDS SP70585_1479 NC_012468.1 1369567 1370931 D identified by match to protein family HMM PF00005; cobalt ABC transporter ATPase component, CbiO 1369567..1370931 Streptococcus pneumoniae 70585 7683622 YP_002740716.1 CDS SP70585_1483 NC_012468.1 1373231 1373554 R identified by match to protein family HMM PF05717; IS66 family element, Orf2 complement(1373231..1373554) Streptococcus pneumoniae 70585 7683280 YP_002740717.1 CDS SP70585_1484 NC_012468.1 1373535 1373720 R hypothetical protein complement(1373535..1373720) Streptococcus pneumoniae 70585 7684640 YP_002740718.1 CDS guaA NC_012468.1 1374024 1375586 R contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase complement(1374024..1375586) Streptococcus pneumoniae 70585 7683614 YP_002740719.1 CDS SP70585_1486 NC_012468.1 1375728 1376426 D identified by match to protein family HMM PF00392; match to protein family HMM PF07702; GntR family transcriptional regulator 1375728..1376426 Streptococcus pneumoniae 70585 7684445 YP_002740720.1 CDS SP70585_1487 NC_012468.1 1376469 1377365 R identified by match to protein family HMM PF00892; membrane protein complement(1376469..1377365) Streptococcus pneumoniae 70585 7682953 YP_002740721.1 CDS SP70585_1488 NC_012468.1 1377374 1378309 R identified by match to protein family HMM PF00144; beta-lactamase complement(1377374..1378309) Streptococcus pneumoniae 70585 7683397 YP_002740722.1 CDS SP70585_1489 NC_012468.1 1378306 1379031 R CppA protein complement(1378306..1379031) Streptococcus pneumoniae 70585 7683458 YP_002740723.1 CDS SP70585_1490 NC_012468.1 1379115 1379750 R identified by match to protein family HMM PF00657; hypothetical protein complement(1379115..1379750) Streptococcus pneumoniae 70585 7683631 YP_002740724.1 CDS SP70585_1491 NC_012468.1 1379752 1380579 R identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; hydrolase complement(1379752..1380579) Streptococcus pneumoniae 70585 7684568 YP_002740725.1 CDS SP70585_1496 NC_012468.1 1381742 1381855 D hypothetical protein 1381742..1381855 Streptococcus pneumoniae 70585 7685137 YP_002740726.1 CDS SP70585_1495 NC_012468.1 1381809 1381958 R hypothetical protein complement(1381809..1381958) Streptococcus pneumoniae 70585 7683175 YP_002740727.1 CDS def NC_012468.1 1382179 1382790 D cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 1382179..1382790 Streptococcus pneumoniae 70585 7684133 YP_002740728.1 CDS SP70585_1498 NC_012468.1 1382835 1383563 D identified by match to protein family HMM PF00588; match to protein family HMM PF08032; match to protein family HMM TIGR00186; RNA methyltransferase, TrmH family, group 3 1382835..1383563 Streptococcus pneumoniae 70585 7684896 YP_002740729.1 CDS trxB NC_012468.1 1383602 1384513 R identified by match to protein family HMM PF00070; match to protein family HMM PF01134; match to protein family HMM PF03486; match to protein family HMM PF07992; match to protein family HMM TIGR01292; thioredoxin-disulfide reductase complement(1383602..1384513) Streptococcus pneumoniae 70585 7682950 YP_002740730.1 CDS SP70585_1500 NC_012468.1 1384579 1384803 R hypothetical protein complement(1384579..1384803) Streptococcus pneumoniae 70585 7683413 YP_002740731.1 CDS SP70585_1501 NC_012468.1 1384881 1385624 R identified by match to protein family HMM PF00005; L-cystine import ATP-binding protein TcyN complement(1384881..1385624) Streptococcus pneumoniae 70585 7683637 YP_002740732.1 CDS SP70585_1502 NC_012468.1 1385624 1386424 R identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; aspartate/glutamate ABC transporter permease complement(1385624..1386424) Streptococcus pneumoniae 70585 7683461 YP_002740733.1 CDS SP70585_1503 NC_012468.1 1386582 1386938 R identified by match to protein family HMM PF03960; match to protein family HMM TIGR01617; arsenate reductase complement(1386582..1386938) Streptococcus pneumoniae 70585 7684506 YP_002740734.1 CDS SP70585_1504 NC_012468.1 1386932 1387462 R identified by match to protein family HMM PF01035; match to protein family HMM TIGR00589; O6-methylguanine-DNA methyltransferase complement(1386932..1387462) Streptococcus pneumoniae 70585 7683527 YP_002740735.1 CDS SP70585_1505 NC_012468.1 1387462 1387956 R identified by match to protein family HMM PF00583; acetyltransferase, gnat family complement(1387462..1387956) Streptococcus pneumoniae 70585 7684178 YP_002740736.1 CDS SP70585_1506 NC_012468.1 1388091 1388537 D identified by match to protein family HMM PF08876; hypothetical protein 1388091..1388537 Streptococcus pneumoniae 70585 7684870 YP_002740737.1 CDS SP70585_1507 NC_012468.1 1388534 1389181 D identified by match to protein family HMM PF03006; match to protein family HMM TIGR01065; hemolysin-3 (Hemolysin III) (Hly-III) 1388534..1389181 Streptococcus pneumoniae 70585 7684119 YP_002740738.1 CDS SP70585_1508 NC_012468.1 1389202 1389783 R with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate; glutamine amidotransferase subunit PdxT complement(1389202..1389783) Streptococcus pneumoniae 70585 7684584 YP_002740739.1 CDS SP70585_1509 NC_012468.1 1389784 1390659 R with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate; pyridoxal biosynthesis lyase PdxS complement(1389784..1390659) Streptococcus pneumoniae 70585 7684777 YP_002740740.1 CDS SP70585_1510 NC_012468.1 1390811 1392190 R identified by match to protein family HMM PF00070; match to protein family HMM PF02852; match to protein family HMM PF07992; NADH oxidase (noxase) complement(1390811..1392190) Streptococcus pneumoniae 70585 7684911 YP_002740741.1 CDS SP70585_1511 NC_012468.1 1392332 1392487 D hypothetical protein 1392332..1392487 Streptococcus pneumoniae 70585 7684823 YP_002740742.1 CDS SP70585_1512 NC_012468.1 1392484 1393407 D identified by match to protein family HMM PF02424; thiamine biosynthesis lipoprotein 1392484..1393407 Streptococcus pneumoniae 70585 7682954 YP_002740743.1 CDS SP70585_1513 NC_012468.1 1393467 1394072 D identified by match to protein family HMM PF03358; NADPH-dependent fmn reductase domain protein 1393467..1394072 Streptococcus pneumoniae 70585 7683380 YP_002740744.1 CDS SP70585_1514 NC_012468.1 1394091 1395335 D identified by match to protein family HMM PF03358; NADPH-dependent fmn reductase domain protein 1394091..1395335 Streptococcus pneumoniae 70585 7683496 YP_002740745.1 CDS SP70585_1515 NC_012468.1 1395452 1395709 R identified by match to protein family HMM PF05979; hypothetical protein complement(1395452..1395709) Streptococcus pneumoniae 70585 7683802 YP_002740746.1 CDS glyS NC_012468.1 1395751 1397787 R glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta complement(1395751..1397787) Streptococcus pneumoniae 70585 7684075 YP_002740747.1 CDS glyQ NC_012468.1 1398047 1398964 R glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha complement(1398047..1398964) Streptococcus pneumoniae 70585 7683150 YP_002740748.1 CDS SP70585_1518 NC_012468.1 1399332 1400093 R hypothetical protein complement(1399332..1400093) Streptococcus pneumoniae 70585 7684848 YP_002740749.1 CDS SP70585_1519 NC_012468.1 1400366 1401208 R identified by match to protein family HMM PF00248; 2,5-diketo-D-gluconic acid reductase A complement(1400366..1401208) Streptococcus pneumoniae 70585 7683774 YP_002740750.1 CDS SP70585_1520 NC_012468.1 1401322 1402659 R identified by match to protein family HMM PF01522; peptidoglycan GlcNAc deacetylase complement(1401322..1402659) Streptococcus pneumoniae 70585 7684807 YP_002740751.1 CDS SP70585_1521 NC_012468.1 1402948 1403325 R hypothetical protein complement(1402948..1403325) Streptococcus pneumoniae 70585 7684917 YP_002740752.1 CDS SP70585_1522 NC_012468.1 1403558 1404535 D identified by match to protein family HMM PF01118; match to protein family HMM PF01408; oxidoreductase 1403558..1404535 Streptococcus pneumoniae 70585 7684800 YP_002740753.1 CDS SP70585_1523 NC_012468.1 1404532 1405614 D identified by match to protein family HMM PF00270; match to protein family HMM PF00271; DEAD RNA helicase 1404532..1405614 Streptococcus pneumoniae 70585 7685145 YP_002740754.1 CDS SP70585_1524 NC_012468.1 1405750 1406187 R transposase complement(1405750..1406187) Streptococcus pneumoniae 70585 7683005 YP_002740755.1 CDS SP70585_1525 NC_012468.1 1406219 1406485 R transposase complement(1406219..1406485) Streptococcus pneumoniae 70585 7683838 YP_002740756.1 CDS SP70585_1526 NC_012468.1 1406563 1406724 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase complement(1406563..1406724) Streptococcus pneumoniae 70585 7683353 YP_002740757.1 CDS tuf NC_012468.1 1407108 1408304 R EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu complement(1407108..1408304) Streptococcus pneumoniae 70585 7684439 YP_002740758.1 CDS SP70585_1528 NC_012468.1 1408736 1409113 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01609; transposase (IS4 family) complement(1408736..1409113) Streptococcus pneumoniae 70585 7684008 YP_002740759.1 CDS SP70585_1529 NC_012468.1 1409125 1409586 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase complement(1409125..1409586) Streptococcus pneumoniae 70585 7683179 YP_002740760.1 CDS SP70585_1530 NC_012468.1 1410099 1410968 R identified by match to protein family HMM PF00230; glycerol facilitator-aquaporin gla (Aquaglyceroporin)(Glyceroaquaporin) complement(1410099..1410968) Streptococcus pneumoniae 70585 7683586 YP_002740761.1 CDS SP70585_1531 NC_012468.1 1411191 1411712 R identified by match to protein family HMM PF00746; match to protein family HMM PF06458; match to protein family HMM TIGR01167; MucBP domain family complement(1411191..1411712) Streptococcus pneumoniae 70585 7684093 YP_002740762.1 CDS SP70585_1532 NC_012468.1 1411670 1412749 R hypothetical protein complement(1411670..1412749) Streptococcus pneumoniae 70585 7685116 YP_002740763.1 CDS SP70585_1533 NC_012468.1 1412860 1413114 R hypothetical protein complement(1412860..1413114) Streptococcus pneumoniae 70585 7684851 YP_002740764.1 CDS SP70585_1534 NC_012468.1 1413472 1414005 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase complement(1413472..1414005) Streptococcus pneumoniae 70585 7683743 YP_002740765.1 CDS SP70585_1535 NC_012468.1 1413992 1414207 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; hypothetical protein complement(1413992..1414207) Streptococcus pneumoniae 70585 7684412 YP_002740766.1 CDS SP70585_1536 NC_012468.1 1414551 1416269 D identified by match to protein family HMM PF00408; match to protein family HMM PF02878; match to protein family HMM PF02879; match to protein family HMM PF02880; phosphomannomutase 1414551..1416269 Streptococcus pneumoniae 70585 7683612 YP_002740767.1 CDS SP70585_1537 NC_012468.1 1416380 1416727 D identified by match to protein family HMM TIGR01295; bacterocin transport accessory protein 1416380..1416727 Streptococcus pneumoniae 70585 7684013 YP_002740768.1 CDS SP70585_1538 NC_012468.1 1417005 1417841 R identified by match to protein family HMM PF00497; ABC transporter substrate-binding protein - glutamine transport complement(1417005..1417841) Streptococcus pneumoniae 70585 7683045 YP_002740769.1 CDS SP70585_1539 NC_012468.1 1417854 1418483 R identified by match to protein family HMM PF00005; glutamine transport ATP-binding protein GlnQ complement(1417854..1418483) Streptococcus pneumoniae 70585 7684831 YP_002740770.1 CDS SP70585_1540 NC_012468.1 1418493 1419134 R identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; amino acid ABC transporter permease complement(1418493..1419134) Streptococcus pneumoniae 70585 7684522 YP_002740771.1 CDS SP70585_1541 NC_012468.1 1419280 1420509 R identified by match to protein family HMM PF00515; match to protein family HMM PF07719; TPR domain protein complement(1419280..1420509) Streptococcus pneumoniae 70585 7683379 YP_002740772.1 CDS SP70585_1542 NC_012468.1 1420499 1421665 R identified by match to protein family HMM PF01594; transport protein complement(1420499..1421665) Streptococcus pneumoniae 70585 7683058 YP_002740773.1 CDS SP70585_1543 NC_012468.1 1421809 1422822 D 3-carboxymuconate cyclase 1421809..1422822 Streptococcus pneumoniae 70585 7684495 YP_002740774.1 CDS atpC NC_012468.1 1422867 1423286 R part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; F0F1 ATP synthase subunit epsilon complement(1422867..1423286) Streptococcus pneumoniae 70585 7685179 YP_002740775.1 CDS atpD NC_012468.1 1423297 1424703 R Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; F0F1 ATP synthase subunit beta complement(1423297..1424703) Streptococcus pneumoniae 70585 7685009 YP_002740776.1 CDS atpG NC_012468.1 1424789 1425667 R Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; F0F1 ATP synthase subunit gamma complement(1424789..1425667) Streptococcus pneumoniae 70585 7684362 YP_002740777.1 CDS atpA NC_012468.1 1425683 1427188 R produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; F0F1 ATP synthase subunit alpha complement(1425683..1427188) Streptococcus pneumoniae 70585 7684003 YP_002740778.1 CDS atpH NC_012468.1 1427203 1427739 R Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit delta complement(1427203..1427739) Streptococcus pneumoniae 70585 7683331 YP_002740779.1 CDS atpF NC_012468.1 1427739 1428233 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; F0F1 ATP synthase subunit B complement(1427739..1428233) Streptococcus pneumoniae 70585 7684194 YP_002740780.1 CDS atpB NC_012468.1 1428247 1428963 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; F0F1 ATP synthase subunit A complement(1428247..1428963) Streptococcus pneumoniae 70585 7684023 YP_002740781.1 CDS SP70585_1551 NC_012468.1 1428998 1429198 R produces ATP from ADP in the presence of a proton gradient across the membrane; subunit C is part of the membrane proton channel F0; F0F1 ATP synthase subunit C complement(1428998..1429198) Streptococcus pneumoniae 70585 7683884 YP_002740782.1 CDS SP70585_1554 NC_012468.1 1430694 1430936 R acetyltransferase, gnat family protein complement(1430694..1430936) Streptococcus pneumoniae 70585 7683647 YP_002740783.1 CDS SP70585_1555 NC_012468.1 1431064 1431612 D hypothetical protein 1431064..1431612 Streptococcus pneumoniae 70585 7684352 YP_002740784.1 CDS greA NC_012468.1 1431669 1432151 R necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA complement(1431669..1432151) Streptococcus pneumoniae 70585 7684938 YP_002740785.1 CDS SP70585_1557 NC_012468.1 1432222 1433877 R identified by match to protein family HMM PF02618; match to protein family HMM TIGR00247; aminodeoxychorismate lyase complement(1432222..1433877) Streptococcus pneumoniae 70585 7684161 YP_002740786.1 CDS SP70585_1558 NC_012468.1 1433958 1434452 R identified by match to protein family HMM PF00583; acetyltransferase, gnat family complement(1433958..1434452) Streptococcus pneumoniae 70585 7683245 YP_002740787.1 CDS SP70585_1559 NC_012468.1 1434449 1434913 R identified by match to protein family HMM PF00583; acetyltransferase, gnat family complement(1434449..1434913) Streptococcus pneumoniae 70585 7684248 YP_002740788.1 CDS murC NC_012468.1 1434923 1436257 R Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase complement(1434923..1436257) Streptococcus pneumoniae 70585 7684733 YP_002740789.1 CDS SP70585_1561 NC_012468.1 1436268 1436885 R hypothetical protein complement(1436268..1436885) Streptococcus pneumoniae 70585 7683557 YP_002740790.1 CDS SP70585_1562 NC_012468.1 1436933 1440031 R identified by match to protein family HMM PF00176; match to protein family HMM PF00271; match to protein family HMM PF04434; match to protein family HMM PF08455; Snf2 family protein complement(1436933..1440031) Streptococcus pneumoniae 70585 7683693 YP_002740791.1 CDS SP70585_1563 NC_012468.1 1440124 1441290 R identified by match to protein family HMM PF00155; putative aminotransferase B complement(1440124..1441290) Streptococcus pneumoniae 70585 7683170 YP_002740792.1 CDS SP70585_1564 NC_012468.1 1441298 1442392 R catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; cystathionine gamma-synthase complement(1441298..1442392) Streptococcus pneumoniae 70585 7684047 YP_002740793.1 CDS SP70585_1567 NC_012468.1 1444397 1446355 R identified by match to protein family HMM PF00496; oligopeptide binding lipoprotein complement(1444397..1446355) Streptococcus pneumoniae 70585 7684320 YP_002740794.1 CDS SP70585_1568 NC_012468.1 1446558 1448180 R identified by match to protein family HMM PF01943; match to protein family HMM PF03023; polysaccharide transporter complement(1446558..1448180) Streptococcus pneumoniae 70585 7682915 YP_002740795.1 CDS SP70585_1569 NC_012468.1 1448286 1449731 D involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of lysine to UDP-N-acetylmuramoyl-L-alanyl-D-glutamate forming UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine; UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase 1448286..1449731 Streptococcus pneumoniae 70585 7684391 YP_002740796.1 CDS SP70585_1570 NC_012468.1 1449774 1449971 R identified by match to protein family HMM PF05532; hypothetical protein complement(1449774..1449971) Streptococcus pneumoniae 70585 7684765 YP_002740797.1 CDS SP70585_1571 NC_012468.1 1450072 1450668 R identified by match to protein family HMM PF08820; hypothetical protein complement(1450072..1450668) Streptococcus pneumoniae 70585 7683031 YP_002740798.1 CDS SP70585_1572 NC_012468.1 1450705 1451217 R hypothetical protein complement(1450705..1451217) Streptococcus pneumoniae 70585 7684923 YP_002740799.1 CDS SP70585_1573 NC_012468.1 1451304 1452239 R catalyzes the hydrolysis of pyrophosphate to phosphate; putative manganese-dependent inorganic pyrophosphatase complement(1451304..1452239) Streptococcus pneumoniae 70585 7684824 YP_002740800.1 CDS SP70585_1574 NC_012468.1 1452310 1452609 R identified by match to protein family HMM PF01541; hypothetical protein complement(1452310..1452609) Streptococcus pneumoniae 70585 7684820 YP_002740801.1 CDS SP70585_1575 NC_012468.1 1452599 1453348 R identified by match to protein family HMM PF05175; methyltransferase complement(1452599..1453348) Streptococcus pneumoniae 70585 7684689 YP_002740802.1 CDS SP70585_1576 NC_012468.1 1453402 1453788 R identified by match to protein family HMM PF00575; hypothetical protein complement(1453402..1453788) Streptococcus pneumoniae 70585 7684378 YP_002740803.1 CDS SP70585_1577 NC_012468.1 1453763 1455163 R identified by match to protein family HMM PF00160; match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; Cof family protein/peptidyl-prolyl cis-trans isomerase, cyclophilin type complement(1453763..1455163) Streptococcus pneumoniae 70585 7685104 YP_002740804.1 CDS rpsR NC_012468.1 1455458 1455697 R binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 complement(1455458..1455697) Streptococcus pneumoniae 70585 7684611 YP_002740805.1 CDS SP70585_1579 NC_012468.1 1455729 1456199 R binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein complement(1455729..1456199) Streptococcus pneumoniae 70585 7684888 YP_002740806.1 CDS rpsF NC_012468.1 1456211 1456501 R binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 complement(1456211..1456501) Streptococcus pneumoniae 70585 7682940 YP_002740807.1 CDS asnC NC_012468.1 1456654 1457997 R catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; asparaginyl-tRNA synthetase complement(1456654..1457997) Streptococcus pneumoniae 70585 7684116 YP_002740808.1 CDS SP70585_1582 NC_012468.1 1458016 1458381 R identified by match to protein family HMM PF00903; glyoxalase family protein complement(1458016..1458381) Streptococcus pneumoniae 70585 7683494 YP_002740809.1 CDS SP70585_1583 NC_012468.1 1458374 1459561 R catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; aspartate aminotransferase complement(1458374..1459561) Streptococcus pneumoniae 70585 7684338 YP_002740810.1 CDS SP70585_1584 NC_012468.1 1459558 1460046 R identified by match to protein family HMM PF03413; peptidase propeptide and ypeb domain protein complement(1459558..1460046) Streptococcus pneumoniae 70585 7684876 YP_002740811.1 CDS SP70585_1585 NC_012468.1 1460113 1460229 R identified by glimmer; putative; hypothetical protein complement(1460113..1460229) Streptococcus pneumoniae 70585 7684481 YP_002740812.1 CDS SP70585_1586 NC_012468.1 1460367 1460915 D identified by match to protein family HMM PF02525; match to protein family HMM PF03358; oxidoreductase 1460367..1460915 Streptococcus pneumoniae 70585 7684151 YP_002740813.1 CDS SP70585_1587 NC_012468.1 1461152 1467109 R identified by match to protein family HMM PF01391; match to protein family HMM PF04650; match to protein family HMM PF07501; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; G5 domain family complement(1461152..1467109) Streptococcus pneumoniae 70585 7683966 YP_002740814.1 CDS SP70585_1588 NC_012468.1 1467325 1468809 D identified by match to protein family HMM PF05043; match to protein family HMM PF08270; match to protein family HMM PF08279; match to protein family HMM PF08280; M protein trans-acting positive transcriptional regulator 1467325..1468809 Streptococcus pneumoniae 70585 7683281 YP_002740815.1 CDS SP70585_1589 NC_012468.1 1468860 1469588 R identified by match to protein family HMM PF03883; hypothetical protein complement(1468860..1469588) Streptococcus pneumoniae 70585 7683574 YP_002740816.1 CDS SP70585_1590 NC_012468.1 1469667 1469831 R hypothetical protein complement(1469667..1469831) Streptococcus pneumoniae 70585 7684423 YP_002740817.1 CDS SP70585_1591 NC_012468.1 1469998 1471593 R hypothetical protein complement(1469998..1471593) Streptococcus pneumoniae 70585 7684259 YP_002740818.1 CDS def2 NC_012468.1 1471605 1472015 R cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase complement(1471605..1472015) Streptococcus pneumoniae 70585 7684801 YP_002740819.1 CDS SP70585_1593 NC_012468.1 1472131 1472922 R YghU; B2989; one of eight putative glutathione transferases from E. coli; putative glutathione S-transferase YghU complement(1472131..1472922) Streptococcus pneumoniae 70585 7684542 YP_002740820.1 CDS SP70585_1594 NC_012468.1 1472935 1475631 R identified by match to protein family HMM PF00122; match to protein family HMM PF00689; match to protein family HMM PF00690; match to protein family HMM PF00702; match to protein family HMM TIGR01494; calcium-transporting ATPase 1 complement(1472935..1475631) Streptococcus pneumoniae 70585 7684940 YP_002740821.1 CDS SP70585_1595 NC_012468.1 1475935 1477119 D identified by match to protein family HMM PF01545; match to protein family HMM TIGR01297; cation efflux family protein 1475935..1477119 Streptococcus pneumoniae 70585 7683714 YP_002740822.1 CDS SP70585_1596 NC_012468.1 1477262 1479133 R identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein complement(1477262..1479133) Streptococcus pneumoniae 70585 7683666 YP_002740823.1 CDS SP70585_1597 NC_012468.1 1479130 1480314 R catalyzes the addition and repair of the 3'-terminal CCA sequence in tRNA; these proteins belong to the CCA-adding enzyme subfamily 2 which does not have phosphohydrolase activity; tRNA CCA-pyrophosphorylase complement(1479130..1480314) Streptococcus pneumoniae 70585 7682981 YP_002740824.1 CDS dapB NC_012468.1 1480326 1481093 R catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase complement(1480326..1481093) Streptococcus pneumoniae 70585 7683125 YP_002740825.1 CDS SP70585_1599 NC_012468.1 1481359 1482207 R identified by match to protein family HMM PF02645; match to protein family HMM TIGR00762; hypothetical protein complement(1481359..1482207) Streptococcus pneumoniae 70585 7684139 YP_002740826.1 CDS SP70585_1600 NC_012468.1 1482209 1482583 R identified by match to protein family HMM PF06619; hypothetical protein complement(1482209..1482583) Streptococcus pneumoniae 70585 7683978 YP_002740827.1 CDS glmM NC_012468.1 1482657 1484009 R catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase complement(1482657..1484009) Streptococcus pneumoniae 70585 7684353 YP_002740828.1 CDS SP70585_1602 NC_012468.1 1484033 1484812 R identified by match to protein family HMM PF07949; lipoprotein, putative complement(1484033..1484812) Streptococcus pneumoniae 70585 7682903 YP_002740829.1 CDS SP70585_1603 NC_012468.1 1484799 1485656 R identified by match to protein family HMM PF02457; match to protein family HMM TIGR00159; hypothetical protein complement(1484799..1485656) Streptococcus pneumoniae 70585 7683657 YP_002740830.1 CDS SP70585_1604 NC_012468.1 1485792 1486757 D identified by match to protein family HMM PF00070; match to protein family HMM PF07992; pyridine nucleotide-disulfide oxidoreductase family protein 1485792..1486757 Streptococcus pneumoniae 70585 7683029 YP_002740831.1 CDS SP70585_1605 NC_012468.1 1486791 1487702 R identified by match to protein family HMM PF02650; match to protein family HMM TIGR00647; hypothetical protein complement(1486791..1487702) Streptococcus pneumoniae 70585 7684704 YP_002740832.1 CDS SP70585_1606 NC_012468.1 1487699 1488676 R identified by match to protein family HMM PF01933; match to protein family HMM TIGR01826; transporter complement(1487699..1488676) Streptococcus pneumoniae 70585 7684978 YP_002740833.1 CDS SP70585_1607 NC_012468.1 1488673 1489563 R identified by match to protein family HMM PF03668; hypothetical protein complement(1488673..1489563) Streptococcus pneumoniae 70585 7683149 YP_002740834.1 CDS SP70585_1608 NC_012468.1 1489615 1489995 R identified by match to protein family HMM PF01042; match to protein family HMM TIGR00004; endoribonuclease L-PSP, putative complement(1489615..1489995) Streptococcus pneumoniae 70585 7684430 YP_002740835.1 CDS engB NC_012468.1 1490006 1490593 R binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC complement(1490006..1490593) Streptococcus pneumoniae 70585 7683776 YP_002740836.1 CDS clpX NC_012468.1 1490602 1491834 R binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX complement(1490602..1491834) Streptococcus pneumoniae 70585 7683433 YP_002740837.1 CDS SP70585_1611 NC_012468.1 1491866 1492036 R hypothetical protein complement(1491866..1492036) Streptococcus pneumoniae 70585 7683707 YP_002740838.1 CDS folA NC_012468.1 1492036 1492542 R identified by match to protein family HMM PF00186; dihydrofolate reductase complement(1492036..1492542) Streptococcus pneumoniae 70585 7684873 YP_002740839.1 CDS SP70585_1613 NC_012468.1 1492672 1493190 R identified by match to protein family HMM PF00210; DNA protection during starvation protein complement(1492672..1493190) Streptococcus pneumoniae 70585 7684246 YP_002740840.1 CDS SP70585_1614 NC_012468.1 1493686 1495158 R identified by match to protein family HMM PF01183; match to protein family HMM PF01473; 1,4-beta-N-acetylmuramidase complement(1493686..1495158) Streptococcus pneumoniae 70585 7683560 YP_002740841.1 CDS tpiA NC_012468.1 1495229 1495987 R Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase complement(1495229..1495987) Streptococcus pneumoniae 70585 7683174 YP_002740842.1 CDS SP70585_1616 NC_012468.1 1496085 1496762 R identified by match to protein family HMM PF04271; match to protein family HMM TIGR01446; DNA replication protein DnaD complement(1496085..1496762) Streptococcus pneumoniae 70585 7684918 YP_002740843.1 CDS metA NC_012468.1 1496771 1497715 R catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis; homoserine O-succinyltransferase complement(1496771..1497715) Streptococcus pneumoniae 70585 7684782 YP_002740844.1 CDS apt NC_012468.1 1497897 1498409 R catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase complement(1497897..1498409) Streptococcus pneumoniae 70585 7683205 YP_002740845.1 CDS SP70585_1619 NC_012468.1 1498496 1499254 R identified by match to protein family HMM PF08241; match to protein family HMM PF08242; SAM-dependent methyltransferase complement(1498496..1499254) Streptococcus pneumoniae 70585 7684753 YP_002740846.1 CDS SP70585_1620 NC_012468.1 1499755 1500885 R identified by match to protein family HMM PF00005; match to protein family HMM PF03459; match to protein family HMM PF08402; multiple sugar-binding transport ATP-binding protein MsmK complement(1499755..1500885) Streptococcus pneumoniae 70585 7683608 YP_002740847.1 CDS SP70585_1621 NC_012468.1 1500986 1501108 D identified by glimmer; putative; hypothetical protein 1500986..1501108 Streptococcus pneumoniae 70585 7683180 YP_002740848.1 CDS SP70585_1623 NC_012468.1 1501335 1501910 R identified by match to protein family HMM PF00857; isochorismatase complement(1501335..1501910) Streptococcus pneumoniae 70585 7684316 YP_002740849.1 CDS codY NC_012468.1 1501910 1502698 R CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase (By similarity). It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; transcriptional repressor CodY complement(1501910..1502698) Streptococcus pneumoniae 70585 7683683 YP_002740850.1 CDS SP70585_1625 NC_012468.1 1502962 1504536 R identified by match to protein family HMM PF00270; match to protein family HMM PF00271; cold-shock DEAD box protein A complement(1502962..1504536) Streptococcus pneumoniae 70585 7682926 YP_002740851.1 CDS SP70585_1626 NC_012468.1 1504735 1505019 R major facilitator:Oxalate:Formate Antiporter complement(1504735..1505019) Streptococcus pneumoniae 70585 7684979 YP_002740852.1 CDS SP70585_1627 NC_012468.1 1505113 1505490 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01609; transposase (IS4 family) complement(1505113..1505490) Streptococcus pneumoniae 70585 7684511 YP_002740853.1 CDS SP70585_1628 NC_012468.1 1505502 1505963 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase complement(1505502..1505963) Streptococcus pneumoniae 70585 7684437 YP_002740854.1 CDS SP70585_1629 NC_012468.1 1505953 1506834 R identified by match to protein family HMM PF07690; oxalate:formate antiporter complement(1505953..1506834) Streptococcus pneumoniae 70585 7684213 YP_002740855.1 CDS SP70585_1630 NC_012468.1 1507027 1508343 D Involved in disulfide oxidoreductase activity and electron transport; pyridine nucleotide-disulfide oxidoreductase 1507027..1508343 Streptococcus pneumoniae 70585 7684885 YP_002740856.1 CDS SP70585_1631 NC_012468.1 1508442 1509785 D identified by match to protein family HMM PF08245; match to protein family HMM PF08353; Mur ligase family protein 1508442..1509785 Streptococcus pneumoniae 70585 7684271 YP_002740857.1 CDS SP70585_1632 NC_012468.1 1509785 1510567 D identified by match to protein family HMM PF07685; cobyric acid synthase 1509785..1510567 Streptococcus pneumoniae 70585 7683412 YP_002740858.1 CDS SP70585_1633 NC_012468.1 1510693 1511775 D identified by match to protein family HMM PF00557; match to protein family HMM PF01321; Xaa-Pro dipeptidase (X-Pro dipeptidase) (Prolinedipeptidase) (Prolidase) (Imidodipeptidase) 1510693..1511775 Streptococcus pneumoniae 70585 7683185 YP_002740859.1 CDS SP70585_1634 NC_012468.1 1512099 1512932 R identified by match to protein family HMM PF00665; integrase core domain protein complement(1512099..1512932) Streptococcus pneumoniae 70585 7683976 YP_002740860.1 CDS SP70585_1635 NC_012468.1 1513158 1513370 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase complement(1513158..1513370) Streptococcus pneumoniae 70585 7683848 YP_002740861.1 CDS SP70585_1636 NC_012468.1 1513624 1514085 R hypothetical protein complement(1513624..1514085) Streptococcus pneumoniae 70585 7683306 YP_002740862.1 CDS SP70585_1637 NC_012468.1 1514082 1514837 R catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase complement(1514082..1514837) Streptococcus pneumoniae 70585 7683422 YP_002740863.1 CDS truA NC_012468.1 1514827 1515576 R mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A complement(1514827..1515576) Streptococcus pneumoniae 70585 7683853 YP_002740864.1 CDS SP70585_1639 NC_012468.1 1515893 1517044 R identified by match to protein family HMM PF07690; major facilitator superfamily transporter complement(1515893..1517044) Streptococcus pneumoniae 70585 7684784 YP_002740865.1 CDS SP70585_1640 NC_012468.1 1517016 1517132 D identified by glimmer; putative; hypothetical protein 1517016..1517132 Streptococcus pneumoniae 70585 7684625 YP_002740866.1 CDS SP70585_1641 NC_012468.1 1517284 1517913 R hypothetical protein complement(1517284..1517913) Streptococcus pneumoniae 70585 7683994 YP_002740867.1 CDS phnA NC_012468.1 1517916 1518254 R identified by match to protein family HMM PF03831; match to protein family HMM PF08274; match to protein family HMM TIGR00686; alkylphosphonate utilization operon protein PhnA complement(1517916..1518254) Streptococcus pneumoniae 70585 7683260 YP_002740868.1 CDS cmk NC_012468.1 1518384 1519055 R Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase complement(1518384..1519055) Streptococcus pneumoniae 70585 7684371 YP_002740869.1 CDS SP70585_1644 NC_012468.1 1519064 1519540 R hypothetical protein complement(1519064..1519540) Streptococcus pneumoniae 70585 7682944 YP_002740870.1 CDS SP70585_1645 NC_012468.1 1519682 1519798 D ferredoxin 1519682..1519798 Streptococcus pneumoniae 70585 7683051 YP_002740871.1 CDS SP70585_1646 NC_012468.1 1519849 1520814 R identified by match to protein family HMM PF00535; bactoprenol glucosyl transferase complement(1519849..1520814) Streptococcus pneumoniae 70585 7682964 YP_002740872.1 CDS galE NC_012468.1 1520816 1521835 R identified by match to protein family HMM PF00106; match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF04321; match to protein family HMM PF07993; match to protein family HMM TIGR01179; UDP-glucose 4-epimerase complement(1520816..1521835) Streptococcus pneumoniae 70585 7684655 YP_002740873.1 CDS SP70585_1648 NC_012468.1 1521938 1522129 R chlorohydrolase complement(1521938..1522129) Streptococcus pneumoniae 70585 7683108 YP_002740874.1 CDS SP70585_1649 NC_012468.1 1522136 1523239 R identified by match to protein family HMM PF01266; oxidoreductase, DadA family protein complement(1522136..1523239) Streptococcus pneumoniae 70585 7683293 YP_002740875.1 CDS SP70585_1650 NC_012468.1 1523256 1524053 R identified by match to protein family HMM PF01784; match to protein family HMM TIGR00486; hypothetical protein complement(1523256..1524053) Streptococcus pneumoniae 70585 7684349 YP_002740876.1 CDS SP70585_1651 NC_012468.1 1524040 1524717 R identified by match to protein family HMM PF04816; Bcl-2 family protein complement(1524040..1524717) Streptococcus pneumoniae 70585 7683959 YP_002740877.1 CDS SP70585_1652 NC_012468.1 1525266 1526216 D hypothetical protein 1525266..1526216 Streptococcus pneumoniae 70585 7684660 YP_002740878.1 CDS SP70585_1653 NC_012468.1 1526333 1526821 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF00665; integrase core domain, putative complement(1526333..1526821) Streptococcus pneumoniae 70585 7684976 YP_002740879.1 CDS SP70585_1654 NC_012468.1 1526883 1527155 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; hypothetical protein complement(1526883..1527155) Streptococcus pneumoniae 70585 7683028 YP_002740880.1 CDS SP70585_1655 NC_012468.1 1527155 1527322 R transposase complement(1527155..1527322) Streptococcus pneumoniae 70585 7683143 YP_002740881.1 CDS SP70585_1656 NC_012468.1 1527458 1527670 R transposase complement(1527458..1527670) Streptococcus pneumoniae 70585 7685070 YP_002740882.1 CDS tkt1 NC_012468.1 1528040 1530010 R catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase complement(1528040..1530010) Streptococcus pneumoniae 70585 7683451 YP_002740883.1 CDS SP70585_1658 NC_012468.1 1530047 1530742 R identified by match to protein family HMM PF00834; allulose-6-phosphate 3-epimerase complement(1530047..1530742) Streptococcus pneumoniae 70585 7684510 YP_002740884.1 CDS SP70585_1659 NC_012468.1 1530753 1531838 R identified by match to protein family HMM PF02378; match to protein family HMM TIGR01427; PTS system, IIC component complement(1530753..1531838) Streptococcus pneumoniae 70585 7683400 YP_002740885.1 CDS SP70585_1660 NC_012468.1 1531864 1532175 R identified by match to protein family HMM PF02379; match to protein family HMM TIGR00829; PTS system, IIB component complement(1531864..1532175) Streptococcus pneumoniae 70585 7682955 YP_002740886.1 CDS SP70585_1661 NC_012468.1 1532203 1532652 R identified by match to protein family HMM PF00359; match to protein family HMM TIGR00848; PTS system, IIA component complement(1532203..1532652) Streptococcus pneumoniae 70585 7683864 YP_002740887.1 CDS SP70585_1662 NC_012468.1 1532630 1533058 R identified by match to protein family HMM PF00359; PTS system, nitrogen regulatory component IIA, putative complement(1532630..1533058) Streptococcus pneumoniae 70585 7683957 YP_002740888.1 CDS SP70585_1663 NC_012468.1 1533051 1534514 R identified by match to protein family HMM PF00874; match to protein family HMM PF05043; match to protein family HMM PF08279; putative transcription antiterminator BglG family protein complement(1533051..1534514) Streptococcus pneumoniae 70585 7683339 YP_002740889.1 CDS SP70585_1664 NC_012468.1 1535043 1537379 R identified by match to protein family HMM PF00122; match to protein family HMM PF00702; match to protein family HMM TIGR01494; P-type ATPase - metal cation transport complement(1535043..1537379) Streptococcus pneumoniae 70585 7683886 YP_002740890.1 CDS SP70585_1665 NC_012468.1 1537512 1538261 D identified by match to protein family HMM PF01553; acyltransferase family protein 1537512..1538261 Streptococcus pneumoniae 70585 7684347 YP_002740891.1 CDS SP70585_1666 NC_012468.1 1538552 1539166 R identified by match to protein family HMM PF03596; match to protein family HMM TIGR00779; CadD complement(1538552..1539166) Streptococcus pneumoniae 70585 7684472 YP_002740892.1 CDS rpsO NC_012468.1 1539980 1540249 R primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 complement(1539980..1540249) Streptococcus pneumoniae 70585 7684273 YP_002740893.1 CDS SP70585_1668 NC_012468.1 1540390 1541019 R YwnB complement(1540390..1541019) Streptococcus pneumoniae 70585 7684368 YP_002740894.1 CDS SP70585_1669 NC_012468.1 1541082 1541204 D hypothetical protein 1541082..1541204 Streptococcus pneumoniae 70585 7684005 YP_002740895.1 CDS SP70585_1670 NC_012468.1 1541889 1542029 D hypothetical protein 1541889..1542029 Streptococcus pneumoniae 70585 7684340 YP_002740896.1 CDS SP70585_1671 NC_012468.1 1542036 1542212 D hypothetical protein 1542036..1542212 Streptococcus pneumoniae 70585 7684236 YP_002740897.1 CDS thrS NC_012468.1 1542270 1544213 D catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); threonyl-tRNA synthetase 1542270..1544213 Streptococcus pneumoniae 70585 7684138 YP_002740898.1 CDS SP70585_1673 NC_012468.1 1544262 1545236 R identified by match to protein family HMM PF02518; histidine kinase complement(1544262..1545236) Streptococcus pneumoniae 70585 7683621 YP_002740899.1 CDS SP70585_1674 NC_012468.1 1545229 1545906 R identified by match to protein family HMM PF00072; match to protein family HMM PF00486; response regulator complement(1545229..1545906) Streptococcus pneumoniae 70585 7684028 YP_002740900.1 CDS SP70585_1675 NC_012468.1 1546062 1547135 D hypothetical protein 1546062..1547135 Streptococcus pneumoniae 70585 7684327 YP_002740901.1 CDS SP70585_1676 NC_012468.1 1547226 1547528 R hypothetical protein complement(1547226..1547528) Streptococcus pneumoniae 70585 7683752 YP_002740902.1 CDS SP70585_1677 NC_012468.1 1547597 1548034 R identified by match to protein family HMM PF02082; Rrf2 family protein complement(1547597..1548034) Streptococcus pneumoniae 70585 7684124 YP_002740903.1 CDS SP70585_1678 NC_012468.1 1548110 1548952 R identified by match to protein family HMM PF00149; metallophosphoesterase complement(1548110..1548952) Streptococcus pneumoniae 70585 7683721 YP_002740904.1 CDS SP70585_1679 NC_012468.1 1549064 1549714 D identified by match to protein family HMM PF01047; match to protein family HMM PF01325; match to protein family HMM PF02742; match to protein family HMM PF04023; iron-dependent transcriptional regulator 1549064..1549714 Streptococcus pneumoniae 70585 7684995 YP_002740905.1 CDS SP70585_1680 NC_012468.1 1549695 1549886 D hypothetical protein 1549695..1549886 Streptococcus pneumoniae 70585 7684030 YP_002740906.1 CDS SP70585_1681 NC_012468.1 1549912 1550559 D hypothetical protein 1549912..1550559 Streptococcus pneumoniae 70585 7684672 YP_002740907.1 CDS SP70585_1682 NC_012468.1 1550594 1550713 R identified by glimmer; putative; hypothetical protein complement(1550594..1550713) Streptococcus pneumoniae 70585 7683748 YP_002740908.1 CDS SP70585_1683 NC_012468.1 1550690 1551103 D hypothetical protein 1550690..1551103 Streptococcus pneumoniae 70585 7683219 YP_002740909.1 CDS SP70585_1684 NC_012468.1 1551374 1551496 D hypothetical protein 1551374..1551496 Streptococcus pneumoniae 70585 7683851 YP_002740910.1 CDS dtd NC_012468.1 1551574 1552017 R hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase complement(1551574..1552017) Streptococcus pneumoniae 70585 7683358 YP_002740911.1 CDS spoT NC_012468.1 1552047 1554269 R identified by match to protein family HMM PF01966; match to protein family HMM PF02824; match to protein family HMM PF04607; match to protein family HMM TIGR00691; guanosine-3,5-bis(diphosphate) 3-pyrophosphohydrolase complement(1552047..1554269) Streptococcus pneumoniae 70585 7683208 YP_002740912.1 CDS SP70585_1687 NC_012468.1 1555263 1555892 D identified by match to protein family HMM PF00753; metallo-beta-lactamase superfamily protein 1555263..1555892 Streptococcus pneumoniae 70585 7683983 YP_002740913.1 CDS SP70585_1688 NC_012468.1 1556014 1557906 R identified by match to protein family HMM PF01431; match to protein family HMM PF05649; endopeptidase O complement(1556014..1557906) Streptococcus pneumoniae 70585 7682985 YP_002740914.1 CDS SP70585_1689 NC_012468.1 1558197 1558919 D identified by match to protein family HMM PF00005; manganese transport system ATP-binding protein MntA 1558197..1558919 Streptococcus pneumoniae 70585 7683785 YP_002740915.1 CDS SP70585_1690 NC_012468.1 1558916 1559764 D identified by match to protein family HMM PF00950; manganese transport system membrane protein MntB 1558916..1559764 Streptococcus pneumoniae 70585 7684137 YP_002740916.1 CDS SP70585_1691 NC_012468.1 1559796 1560725 D identified by match to protein family HMM PF01297; manganese ABC transporter substrate-binding lipoprotein (Adhesin B) (Saliva-binding protein) 1559796..1560725 Streptococcus pneumoniae 70585 7684177 YP_002740917.1 CDS tpx NC_012468.1 1560848 1561339 D antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase 1560848..1561339 Streptococcus pneumoniae 70585 7684084 YP_002740918.1 CDS SP70585_1693 NC_012468.1 1561435 1564143 R identified by match to protein family HMM PF02687; efflux ABC transporter permease complement(1561435..1564143) Streptococcus pneumoniae 70585 7684508 YP_002740919.1 CDS SP70585_1694 NC_012468.1 1564145 1564846 R identified by match to protein family HMM PF00005; macrolide export ATP-binding/permease MacB complement(1564145..1564846) Streptococcus pneumoniae 70585 7683504 YP_002740920.1 CDS SP70585_1695 NC_012468.1 1565096 1567507 R alpha-fucosidase complement(1565096..1567507) Streptococcus pneumoniae 70585 7684343 YP_002740921.1 CDS gpmA NC_012468.1 1567560 1568252 R 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase complement(1567560..1568252) Streptococcus pneumoniae 70585 7684925 YP_002740922.1 CDS SP70585_1697 NC_012468.1 1568303 1568491 R hypothetical protein complement(1568303..1568491) Streptococcus pneumoniae 70585 7684388 YP_002740923.1 CDS SP70585_1698 NC_012468.1 1568787 1569167 R integral membrane protein complement(1568787..1569167) Streptococcus pneumoniae 70585 7683871 YP_002740924.1 CDS ileS NC_012468.1 1569577 1572369 R IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase complement(1569577..1572369) Streptococcus pneumoniae 70585 7684789 YP_002740925.1 CDS SP70585_1700 NC_012468.1 1572622 1572738 R hypothetical protein complement(1572622..1572738) Streptococcus pneumoniae 70585 7684535 YP_002740926.1 CDS SP70585_1701 NC_012468.1 1572717 1573505 R identified by match to protein family HMM PF05103; cell-division initiation protein complement(1572717..1573505) Streptococcus pneumoniae 70585 7684814 YP_002740927.1 CDS SP70585_1702 NC_012468.1 1573514 1574299 R identified by match to protein family HMM PF01479; YlmH protein complement(1573514..1574299) Streptococcus pneumoniae 70585 7684464 YP_002740928.1 CDS SP70585_1703 NC_012468.1 1574296 1574559 R identified by match to protein family HMM PF02325; yggt family, putative complement(1574296..1574559) Streptococcus pneumoniae 70585 7684386 YP_002740929.1 CDS SP70585_1704 NC_012468.1 1574559 1575098 R identified by match to protein family HMM PF04472; YlmF protein complement(1574559..1575098) Streptococcus pneumoniae 70585 7684950 YP_002740930.1 CDS SP70585_1705 NC_012468.1 1575108 1575779 R identified by match to protein family HMM TIGR00044; pyridoxal phosphate enzyme, YggS family complement(1575108..1575779) Streptococcus pneumoniae 70585 7684060 YP_002740931.1 CDS ftsZ NC_012468.1 1575784 1577043 R GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ complement(1575784..1577043) Streptococcus pneumoniae 70585 7684671 YP_002740932.1 CDS ftsA NC_012468.1 1577060 1578433 R identified by match to protein family HMM PF02491; match to protein family HMM TIGR01174; cell division protein FtsA complement(1577060..1578433) Streptococcus pneumoniae 70585 7684549 YP_002740933.1 CDS SP70585_1708 NC_012468.1 1578652 1579356 R identified by match to protein family HMM TIGR02206; hypothetical protein complement(1578652..1579356) Streptococcus pneumoniae 70585 7684206 YP_002740934.1 CDS SP70585_1709 NC_012468.1 1579447 1580058 R identified by match to protein family HMM PF00293; MutT/nudix family protein complement(1579447..1580058) Streptococcus pneumoniae 70585 7684921 YP_002740935.1 CDS SP70585_1710 NC_012468.1 1580045 1581418 R identified by match to protein family HMM PF01225; match to protein family HMM PF02875; match to protein family HMM PF08245; match to protein family HMM TIGR01143; UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanyl ligase complement(1580045..1581418) Streptococcus pneumoniae 70585 7683821 YP_002740936.1 CDS ddl NC_012468.1 1581502 1582545 R D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A complement(1581502..1582545) Streptococcus pneumoniae 70585 7684038 YP_002740937.1 CDS recR NC_012468.1 1582721 1583317 R involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR complement(1582721..1583317) Streptococcus pneumoniae 70585 7683356 YP_002740938.1 CDS SP70585_1713 NC_012468.1 1583328 1585370 R identified by match to protein family HMM PF00905; match to protein family HMM PF03717; penicillin-binding protein 2B complement(1583328..1585370) Streptococcus pneumoniae 70585 7683639 YP_002740939.1 CDS SP70585_1714 NC_012468.1 1585585 1586436 D identified by match to protein family HMM PF01380; match to protein family HMM PF01418; transcriptional regulator, RpiR family 1585585..1586436 Streptococcus pneumoniae 70585 7684574 YP_002740940.1 CDS SP70585_1715 NC_012468.1 1586452 1587336 R identified by match to protein family HMM PF00480; glucokinase complement(1586452..1587336) Streptococcus pneumoniae 70585 7684840 YP_002740941.1 CDS SP70585_1716 NC_012468.1 1587354 1588271 R identified by match to protein family HMM PF00701; N-acetylneuraminate lyase complement(1587354..1588271) Streptococcus pneumoniae 70585 7684987 YP_002740942.1 CDS SP70585_1717 NC_012468.1 1588440 1589084 R identified by match to protein family HMM PF04854; hypothetical protein complement(1588440..1589084) Streptococcus pneumoniae 70585 7684086 YP_002740943.1 CDS SP70585_1718 NC_012468.1 1589371 1589505 R hypothetical protein complement(1589371..1589505) Streptococcus pneumoniae 70585 7683589 YP_002740944.1 CDS SP70585_1719 NC_012468.1 1589812 1590264 R identified by match to protein family HMM PF04074; match to protein family HMM TIGR00022; hypothetical protein complement(1589812..1590264) Streptococcus pneumoniae 70585 7684761 YP_002740945.1 CDS SP70585_1720 NC_012468.1 1590537 1591376 R identified by match to protein family HMM PF00528; sugar ABC transporter permease complement(1590537..1591376) Streptococcus pneumoniae 70585 7683305 YP_002740946.1 CDS SP70585_1721 NC_012468.1 1591392 1592279 R identified by match to protein family HMM PF00528; sugar ABC transporter permease complement(1591392..1592279) Streptococcus pneumoniae 70585 7682920 YP_002740947.1 CDS SP70585_1722 NC_012468.1 1592510 1593838 R identified by match to protein family HMM PF01547; sugar ABC transporter substrate-binding protein complement(1592510..1593838) Streptococcus pneumoniae 70585 7684471 YP_002740948.1 CDS SP70585_1723 NC_012468.1 1593963 1595480 R identified by match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826; pts system maltose- and glucose-specific eiicb component complement(1593963..1595480) Streptococcus pneumoniae 70585 7684878 YP_002740949.1 CDS SP70585_1724 NC_012468.1 1595499 1596197 R Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase complement(1595499..1596197) Streptococcus pneumoniae 70585 7684184 YP_002740950.1 CDS SP70585_1725 NC_012468.1 1596371 1597474 R identified by match to protein family HMM PF01118; match to protein family HMM PF01408; match to protein family HMM PF02894; match to protein family HMM PF03447; putative oxidoreductase YjhC complement(1596371..1597474) Streptococcus pneumoniae 70585 7683965 YP_002740951.1 CDS SP70585_1726 NC_012468.1 1597486 1599579 R identified by match to protein family HMM PF02012; match to protein family HMM PF02973; sialidase B (Neuraminidase B) complement(1597486..1599579) Streptococcus pneumoniae 70585 7684399 YP_002740952.1 CDS SP70585_1727 NC_012468.1 1599598 1600431 R identified by match to protein family HMM PF00528; sugar ABC transporter permease complement(1599598..1600431) Streptococcus pneumoniae 70585 7682922 YP_002740953.1 CDS SP70585_1728 NC_012468.1 1600431 1601315 R identified by match to protein family HMM PF00528; sugar ABC transporter permease complement(1600431..1601315) Streptococcus pneumoniae 70585 7683497 YP_002740954.1 CDS SP70585_1729 NC_012468.1 1601394 1602731 R identified by match to protein family HMM PF01547; sugar ABC transporter substrate-binding protein complement(1601394..1602731) Streptococcus pneumoniae 70585 7684490 YP_002740955.1 CDS SP70585_1730 NC_012468.1 1602750 1603202 R identified by match to protein family HMM PF04074; match to protein family HMM TIGR00022; hypothetical protein complement(1602750..1603202) Streptococcus pneumoniae 70585 7683572 YP_002740956.1 CDS SP70585_1731 NC_012468.1 1604204 1607047 R identified by match to protein family HMM PF02012; match to protein family HMM PF02973; match to protein family HMM TIGR01167; neuraminidase complement(1604204..1607047) Streptococcus pneumoniae 70585 7683195 YP_002740957.1 CDS SP70585_1732 NC_012468.1 1607404 1607631 R hypothetical protein complement(1607404..1607631) Streptococcus pneumoniae 70585 7685186 YP_002740958.1 CDS SP70585_1733 NC_012468.1 1608029 1608442 D identified by glimmer; putative; hypothetical protein 1608029..1608442 Streptococcus pneumoniae 70585 7683869 YP_002740959.1 CDS SP70585_1734 NC_012468.1 1608796 1609776 R identified by match to protein family HMM PF05448; xylan esterase 1 complement(1608796..1609776) Streptococcus pneumoniae 70585 7683499 YP_002740960.1 CDS SP70585_1735 NC_012468.1 1610102 1610350 R identified by glimmer; putative; hypothetical protein complement(1610102..1610350) Streptococcus pneumoniae 70585 7684438 YP_002740961.1 CDS recG NC_012468.1 1610378 1612393 R catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG complement(1610378..1612393) Streptococcus pneumoniae 70585 7685048 YP_002740962.1 CDS alr NC_012468.1 1612412 1613515 R converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase complement(1612412..1613515) Streptococcus pneumoniae 70585 7684822 YP_002740963.1 CDS acpS NC_012468.1 1613505 1613867 R Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase complement(1613505..1613867) Streptococcus pneumoniae 70585 7683077 YP_002740964.1 CDS SP70585_1739 NC_012468.1 1613912 1614943 R catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase complement(1613912..1614943) Streptococcus pneumoniae 70585 7682970 YP_002740965.1 CDS SP70585_1740 NC_012468.1 1614945 1615976 R catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase complement(1614945..1615976) Streptococcus pneumoniae 70585 7683964 YP_002740966.1 CDS secA NC_012468.1 1616057 1618570 R functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA complement(1616057..1618570) Streptococcus pneumoniae 70585 7684126 YP_002740967.1 CDS SP70585_1742 NC_012468.1 1619033 1619665 R identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein complement(1619033..1619665) Streptococcus pneumoniae 70585 7683345 YP_002740968.1 CDS SP70585_1743 NC_012468.1 1619669 1620310 R hypothetical protein complement(1619669..1620310) Streptococcus pneumoniae 70585 7684165 YP_002740969.1 CDS SP70585_1744 NC_012468.1 1620303 1621094 R hypothetical protein complement(1620303..1621094) Streptococcus pneumoniae 70585 7684577 YP_002740970.1 CDS SP70585_1745 NC_012468.1 1621279 1621614 R hypothetical protein complement(1621279..1621614) Streptococcus pneumoniae 70585 7684416 YP_002740971.1 CDS SP70585_1746 NC_012468.1 1621755 1622090 R hypothetical protein complement(1621755..1622090) Streptococcus pneumoniae 70585 7683156 YP_002740972.1 CDS engA NC_012468.1 1622181 1623491 R EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA complement(1622181..1623491) Streptococcus pneumoniae 70585 7685091 YP_002740973.1 CDS SP70585_1750 NC_012468.1 1624215 1625111 R Primosomal protein that may act to load helicase DnaC during DNA replication; primosomal protein DnaI complement(1624215..1625111) Streptococcus pneumoniae 70585 7683591 YP_002740974.1 CDS SP70585_1751 NC_012468.1 1625112 1626281 R identified by match to protein family HMM PF07261; replication initiation and membrane attachment protein complement(1625112..1626281) Streptococcus pneumoniae 70585 7685191 YP_002740975.1 CDS nrdR NC_012468.1 1626282 1626755 R identified by match to protein family HMM PF03477; match to protein family HMM TIGR00244; transcriptional regulator NrdR complement(1626282..1626755) Streptococcus pneumoniae 70585 7684970 YP_002740976.1 CDS SP70585_1753 NC_012468.1 1626895 1627260 D identified by match to protein family HMM PF00392; GntR family transcriptional regulator 1626895..1627260 Streptococcus pneumoniae 70585 7685174 YP_002740977.1 CDS SP70585_1754 NC_012468.1 1627265 1627960 D identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1627265..1627960 Streptococcus pneumoniae 70585 7683403 YP_002740978.1 CDS SP70585_1755 NC_012468.1 1627977 1628744 D ABC transporter ATP-binding protein 1627977..1628744 Streptococcus pneumoniae 70585 7684691 YP_002740979.1 CDS SP70585_1756 NC_012468.1 1629097 1630296 R Na+ ABC transporter permease complement(1629097..1630296) Streptococcus pneumoniae 70585 7683753 YP_002740980.1 CDS SP70585_1757 NC_012468.1 1630293 1631186 R identified by match to protein family HMM PF00005; Na+ ABC transporter ATP-binding protein complement(1630293..1631186) Streptococcus pneumoniae 70585 7684711 YP_002740981.1 CDS SP70585_1758 NC_012468.1 1631309 1631500 D chlorohydrolase 1631309..1631500 Streptococcus pneumoniae 70585 7684036 YP_002740982.1 CDS SP70585_1759 NC_012468.1 1632496 1633113 D identified by match to protein family HMM PF09335; hypothetical protein 1632496..1633113 Streptococcus pneumoniae 70585 7683619 YP_002740983.1 CDS SP70585_1760 NC_012468.1 1633433 1634320 R identified by match to protein family HMM PF00480; fructokinase complement(1633433..1634320) Streptococcus pneumoniae 70585 7685004 YP_002740984.1 CDS SP70585_1761 NC_012468.1 1634469 1636352 R identified by match to protein family HMM PF00358; match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826; match to protein family HMM TIGR00830; match to protein family HMM TIGR01996; pts system, sucrose-specific iibc component complement(1634469..1636352) Streptococcus pneumoniae 70585 7683769 YP_002740985.1 CDS SP70585_1762 NC_012468.1 1636479 1636676 R hypothetical protein complement(1636479..1636676) Streptococcus pneumoniae 70585 7684667 YP_002740986.1 CDS SP70585_1763 NC_012468.1 1636729 1638183 D identified by match to protein family HMM PF00251; match to protein family HMM PF08244; match to protein family HMM TIGR01322; sucrose-6-phosphate hydrolase (Sucrase) (Invertase) 1636729..1638183 Streptococcus pneumoniae 70585 7684040 YP_002740987.1 CDS SP70585_1764 NC_012468.1 1638164 1639129 D identified by match to protein family HMM PF00356; match to protein family HMM PF00532; sucrose operon repressor (Scr operon regulatory protein) 1638164..1639129 Streptococcus pneumoniae 70585 7685019 YP_002740988.1 CDS SP70585_1765 NC_012468.1 1639164 1640438 R identified by match to protein family HMM TIGR00532; hydroxymethylglutaryl-CoA reductase, degradative complement(1639164..1640438) Streptococcus pneumoniae 70585 7683715 YP_002740989.1 CDS SP70585_1766 NC_012468.1 1640438 1641634 R identified by match to protein family HMM PF01154; match to protein family HMM PF08540; match to protein family HMM TIGR01835; hydroxymethylglutaryl-CoA synthase complement(1640438..1641634) Streptococcus pneumoniae 70585 7682880 YP_002740990.1 CDS SP70585_1767 NC_012468.1 1641741 1642028 R hypothetical protein complement(1641741..1642028) Streptococcus pneumoniae 70585 7683256 YP_002740991.1 CDS SP70585_1768 NC_012468.1 1642057 1642446 R identified by match to protein family HMM PF01609; transposase (IS4 family) complement(1642057..1642446) Streptococcus pneumoniae 70585 7683448 YP_002740992.1 CDS SP70585_1769 NC_012468.1 1642472 1642585 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; tranposase complement(1642472..1642585) Streptococcus pneumoniae 70585 7684915 YP_002740993.1 CDS SP70585_1770 NC_012468.1 1642744 1643193 R hypothetical protein complement(1642744..1643193) Streptococcus pneumoniae 70585 7684531 YP_002740994.1 CDS SP70585_1771 NC_012468.1 1643195 1643953 R identified by match to protein family HMM PF06738; hypothetical protein complement(1643195..1643953) Streptococcus pneumoniae 70585 7684432 YP_002740995.1 CDS SP70585_1772 NC_012468.1 1644068 1646047 R identified by match to protein family HMM PF00069; match to protein family HMM PF01163; match to protein family HMM PF03793; Stk1 complement(1644068..1646047) Streptococcus pneumoniae 70585 7684949 YP_002740996.1 CDS SP70585_1773 NC_012468.1 1646044 1646784 R identified by match to protein family HMM PF00481; protein phosphatase PrpC complement(1646044..1646784) Streptococcus pneumoniae 70585 7683467 YP_002740997.1 CDS sun NC_012468.1 1646799 1648112 R identified by match to protein family HMM PF01029; match to protein family HMM PF01189; match to protein family HMM TIGR00563; ribosomal RNA small subunit methyltransferase B complement(1646799..1648112) Streptococcus pneumoniae 70585 7684904 YP_002740998.1 CDS fmt NC_012468.1 1648105 1649040 R modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase complement(1648105..1649040) Streptococcus pneumoniae 70585 7684788 YP_002740999.1 CDS SP70585_1776 NC_012468.1 1649053 1651449 R binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA complement(1649053..1651449) Streptococcus pneumoniae 70585 7683269 YP_002741000.1 CDS SP70585_1777 NC_012468.1 1651515 1651826 R Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega complement(1651515..1651826) Streptococcus pneumoniae 70585 7683775 YP_002741001.1 CDS gmk NC_012468.1 1651854 1652480 R Essential for recycling GMP and indirectly, cGMP; guanylate kinase complement(1651854..1652480) Streptococcus pneumoniae 70585 7683440 YP_002741002.1 CDS SP70585_1779 NC_012468.1 1652610 1654223 R identified by match to protein family HMM PF00013; match to protein family HMM PF01966; match to protein family HMM TIGR00277; match to protein family HMM TIGR03319; hypothetical protein complement(1652610..1654223) Streptococcus pneumoniae 70585 7683312 YP_002741003.1 CDS SP70585_1780 NC_012468.1 1654492 1654722 R identified by match to protein family HMM PF02604; match to protein family HMM TIGR01552; prevent-host-death family protein complement(1654492..1654722) Streptococcus pneumoniae 70585 7683662 YP_002741004.1 CDS SP70585_1781 NC_012468.1 1654960 1656057 R identified by match to protein family HMM PF05636; hypothetical protein complement(1654960..1656057) Streptococcus pneumoniae 70585 7684067 YP_002741005.1 CDS SP70585_1782 NC_012468.1 1656067 1656813 R identified by match to protein family HMM PF08241; match to protein family HMM PF08242; SAM-dependent methyltransferase complement(1656067..1656813) Streptococcus pneumoniae 70585 7685130 YP_002741006.1 CDS SP70585_1783 NC_012468.1 1656916 1657269 R identified by match to protein family HMM PF02410; match to protein family HMM TIGR00090; putative iojap homolog complement(1656916..1657269) Streptococcus pneumoniae 70585 7685193 YP_002741007.1 CDS SP70585_1784 NC_012468.1 1657282 1657782 R identified by match to protein family HMM PF00857; isochorismatase family protein complement(1657282..1657782) Streptococcus pneumoniae 70585 7684929 YP_002741008.1 CDS SP70585_1785 NC_012468.1 1657783 1658376 R identified by match to protein family HMM PF01966; match to protein family HMM TIGR00488; hypothetical protein complement(1657783..1658376) Streptococcus pneumoniae 70585 7684817 YP_002741009.1 CDS nadD NC_012468.1 1658376 1659005 R transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase complement(1658376..1659005) Streptococcus pneumoniae 70585 7684538 YP_002741010.1 CDS SP70585_1787 NC_012468.1 1659057 1659368 R identified by match to protein family HMM PF01985; match to protein family HMM TIGR00253; hypothetical protein complement(1659057..1659368) Streptococcus pneumoniae 70585 7684394 YP_002741011.1 CDS SP70585_1788 NC_012468.1 1659582 1660688 R in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis; GTP-binding protein YqeH complement(1659582..1660688) Streptococcus pneumoniae 70585 7684062 YP_002741012.1 CDS yqeG NC_012468.1 1660691 1661218 R identified by match to protein family HMM TIGR01662; match to protein family HMM TIGR01668; had superfamily (subfamily iiia) phosphatase complement(1660691..1661218) Streptococcus pneumoniae 70585 7685183 YP_002741013.1 CDS SP70585_1790 NC_012468.1 1661233 1662141 R identified by match to protein family HMM PF01544; CorA - magnesium and cobalt transporter complement(1661233..1662141) Streptococcus pneumoniae 70585 7684225 YP_002741014.1 CDS SP70585_1791 NC_012468.1 1662198 1662758 R identified by match to protein family HMM PF00924; small conductance mechanosensitive ion channel complement(1662198..1662758) Streptococcus pneumoniae 70585 7685043 YP_002741015.1 CDS SP70585_1792 NC_012468.1 1663147 1664115 D involved in the import of serine and threonine coupled with the import of sodium; serine/threonine transporter SstT 1663147..1664115 Streptococcus pneumoniae 70585 7683842 YP_002741016.1 CDS SP70585_1793 NC_012468.1 1664183 1665136 D identified by match to protein family HMM PF06081; integral membrane protein 1664183..1665136 Streptococcus pneumoniae 70585 7685039 YP_002741017.1 CDS SP70585_1794 NC_012468.1 1665159 1665536 R hypothetical protein complement(1665159..1665536) Streptococcus pneumoniae 70585 7684436 YP_002741018.1 CDS SP70585_1795 NC_012468.1 1665597 1665821 R hypothetical protein complement(1665597..1665821) Streptococcus pneumoniae 70585 7683111 YP_002741019.1 CDS SP70585_1796 NC_012468.1 1665826 1666005 R hypothetical protein complement(1665826..1666005) Streptococcus pneumoniae 70585 7684854 YP_002741020.1 CDS SP70585_1797 NC_012468.1 1666007 1667344 R identified by match to protein family HMM TIGR02919; hypothetical protein complement(1666007..1667344) Streptococcus pneumoniae 70585 7684182 YP_002741021.1 CDS SP70585_1798 NC_012468.1 1667337 1668848 R identified by match to protein family HMM PF00534; match to protein family HMM PF09318; match to protein family HMM TIGR02918; hypothetical protein complement(1667337..1668848) Streptococcus pneumoniae 70585 7684869 YP_002741022.1 CDS SP70585_1801 NC_012468.1 1671226 1671666 R accessory secretory protein Asp3 complement(1671226..1671666) Streptococcus pneumoniae 70585 7683121 YP_002741023.1 CDS SP70585_1802 NC_012468.1 1671663 1673198 R accessory secretory protein Asp2 complement(1671663..1673198) Streptococcus pneumoniae 70585 7685163 YP_002741024.1 CDS SP70585_1803 NC_012468.1 1673182 1674762 R accessory secretory protein Asp1 complement(1673182..1674762) Streptococcus pneumoniae 70585 7683268 YP_002741025.1 CDS secY NC_012468.1 1674772 1675989 R forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY complement(1674772..1675989) Streptococcus pneumoniae 70585 7682907 YP_002741026.1 CDS SP70585_1805 NC_012468.1 1676046 1676951 R identified by match to protein family HMM PF00535; glycosyl transferase, family 2 complement(1676046..1676951) Streptococcus pneumoniae 70585 7683282 YP_002741027.1 CDS SP70585_1806 NC_012468.1 1676951 1678147 R identified by match to protein family HMM PF01501; glycosyl transferase, family 8 complement(1676951..1678147) Streptococcus pneumoniae 70585 7684447 YP_002741028.1 CDS SP70585_1807 NC_012468.1 1678156 1679205 R identified by match to protein family HMM PF01501; glycosyl transferase, family 8 complement(1678156..1679205) Streptococcus pneumoniae 70585 7683618 YP_002741029.1 CDS SP70585_1808 NC_012468.1 1679407 1681851 R identified by match to protein family HMM PF01501; match to protein family HMM PF08759; glycosyl transferase, family 8 complement(1679407..1681851) Streptococcus pneumoniae 70585 7684039 YP_002741030.1 CDS SP70585_1809 NC_012468.1 1681861 1682871 R hypothetical protein complement(1681861..1682871) Streptococcus pneumoniae 70585 7684931 YP_002741031.1 CDS SP70585_1811 NC_012468.1 1683817 1684695 R identified by match to protein family HMM PF00132; exopolysaccharide biosynthesis protein, acetyltransferase complement(1683817..1684695) Streptococcus pneumoniae 70585 7683844 YP_002741032.1 CDS SP70585_1812 NC_012468.1 1684692 1686386 R identified by match to protein family HMM PF01501; glycosyl transferase, family 2/glycosyl transferase family 8 complement(1684692..1686386) Streptococcus pneumoniae 70585 7683554 YP_002741033.1 CDS SP70585_1813 NC_012468.1 1686428 1686805 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01609; transposase (IS4 family) complement(1686428..1686805) Streptococcus pneumoniae 70585 7684941 YP_002741034.1 CDS SP70585_1814 NC_012468.1 1686817 1687278 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase complement(1686817..1687278) Streptococcus pneumoniae 70585 7684268 YP_002741035.1 CDS SP70585_1815 NC_012468.1 1687281 1687640 R putative glycosyltransferase YibD complement(1687281..1687640) Streptococcus pneumoniae 70585 7683630 YP_002741036.1 CDS SP70585_1816 NC_012468.1 1687701 1694348 R identified by match to protein family HMM PF00746; match to protein family HMM TIGR01167; cell wall surface anchor family protein complement(1687701..1694348) Streptococcus pneumoniae 70585 7683066 YP_002741037.1 CDS SP70585_1817 NC_012468.1 1694687 1695007 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; Spn1, transposase Orf2 complement(1694687..1695007) Streptococcus pneumoniae 70585 7684696 YP_002741038.1 CDS SP70585_1818 NC_012468.1 1694983 1695156 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; hypothetical protein complement(1694983..1695156) Streptococcus pneumoniae 70585 7682916 YP_002741039.1 CDS SP70585_1819 NC_012468.1 1695533 1695913 D identified by match to protein family HMM PF01047; transcriptional regulator, putative 1695533..1695913 Streptococcus pneumoniae 70585 7683257 YP_002741040.1 CDS SP70585_1820 NC_012468.1 1696012 1696233 D hypothetical protein 1696012..1696233 Streptococcus pneumoniae 70585 7683696 YP_002741041.1 CDS trx NC_012468.1 1696250 1696564 D identified by match to protein family HMM PF00085; match to protein family HMM TIGR01068; thioredoxin 1696250..1696564 Streptococcus pneumoniae 70585 7684502 YP_002741042.1 CDS SP70585_1822 NC_012468.1 1696872 1697405 D NADPH-dependent; catalyzes the reduction of 7-cyano-7-deazaguanine to 7-aminomethyl-7-deazaguanine in queuosine biosynthesis; 7-cyano-7-deazaguanine reductase 1696872..1697405 Streptococcus pneumoniae 70585 7684011 YP_002741043.1 CDS SP70585_1823 NC_012468.1 1697659 1698327 R identified by match to protein family HMM PF00230; aquaporin Z - water channel protein complement(1697659..1698327) Streptococcus pneumoniae 70585 7684198 YP_002741044.1 CDS SP70585_1824 NC_012468.1 1698438 1699229 R hypothetical protein complement(1698438..1699229) Streptococcus pneumoniae 70585 7684122 YP_002741045.1 CDS SP70585_1825 NC_012468.1 1699297 1699452 R identified by glimmer; putative; hypothetical protein complement(1699297..1699452) Streptococcus pneumoniae 70585 7682934 YP_002741046.1 CDS pepF2 NC_012468.1 1699476 1701272 R identified by match to protein family HMM PF01432; match to protein family HMM PF08439; match to protein family HMM TIGR00181; oligoendopeptidase F complement(1699476..1701272) Streptococcus pneumoniae 70585 7683214 YP_002741047.1 CDS SP70585_1827 NC_012468.1 1701283 1702026 R in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE complement(1701283..1702026) Streptococcus pneumoniae 70585 7684743 YP_002741048.1 CDS prmA NC_012468.1 1702028 1702978 R methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; ribosomal protein L11 methyltransferase complement(1702028..1702978) Streptococcus pneumoniae 70585 7683484 YP_002741049.1 CDS SP70585_1829 NC_012468.1 1703116 1703544 R identified by match to protein family HMM PF00293; 7,8-dihydro-8-oxoguanine-triphosphatase complement(1703116..1703544) Streptococcus pneumoniae 70585 7684380 YP_002741050.1 CDS SP70585_1830 NC_012468.1 1703525 1704613 R identified by match to protein family HMM PF02163; peptidase, M50 family protein complement(1703525..1704613) Streptococcus pneumoniae 70585 7683444 YP_002741051.1 CDS SP70585_1831 NC_012468.1 1704632 1705102 R hypothetical protein complement(1704632..1705102) Streptococcus pneumoniae 70585 7683813 YP_002741052.1 CDS SP70585_1832 NC_012468.1 1705393 1705845 R identified by match to protein family HMM PF03681; hypothetical protein complement(1705393..1705845) Streptococcus pneumoniae 70585 7683522 YP_002741053.1 CDS SP70585_1833 NC_012468.1 1705882 1706061 R identified by match to protein family HMM PF07927; hypothetical protein complement(1705882..1706061) Streptococcus pneumoniae 70585 7684097 YP_002741054.1 CDS SP70585_1834 NC_012468.1 1706198 1706377 R hypothetical protein complement(1706198..1706377) Streptococcus pneumoniae 70585 7683183 YP_002741055.1 CDS SP70585_1835 NC_012468.1 1706581 1706781 R hypothetical protein complement(1706581..1706781) Streptococcus pneumoniae 70585 7685135 YP_002741056.1 CDS SP70585_1836 NC_012468.1 1707051 1708322 D identified by match to protein family HMM PF00004; recombination factor protein RarA 1707051..1708322 Streptococcus pneumoniae 70585 7684846 YP_002741057.1 CDS SP70585_1838 NC_012468.1 1708742 1709707 R identified by match to protein family HMM PF00589; integrase complement(1708742..1709707) Streptococcus pneumoniae 70585 7683914 YP_002741058.1 CDS SP70585_1839 NC_012468.1 1709870 1710052 R hypothetical protein complement(1709870..1710052) Streptococcus pneumoniae 70585 7683513 YP_002741059.1 CDS SP70585_1840 NC_012468.1 1710068 1711111 R hypothetical protein complement(1710068..1711111) Streptococcus pneumoniae 70585 7684168 YP_002741060.1 CDS SP70585_1841 NC_012468.1 1711245 1711412 R identified by glimmer; putative; hypothetical protein complement(1711245..1711412) Streptococcus pneumoniae 70585 7684685 YP_002741061.1 CDS SP70585_1842 NC_012468.1 1711684 1712991 R identified by glimmer; putative; hypothetical protein complement(1711684..1712991) Streptococcus pneumoniae 70585 7683128 YP_002741062.1 CDS SP70585_1843 NC_012468.1 1712999 1713121 R identified by glimmer; putative; hypothetical protein complement(1712999..1713121) Streptococcus pneumoniae 70585 7684546 YP_002741063.1 CDS SP70585_1844 NC_012468.1 1713207 1713428 R identified by glimmer; putative; hypothetical protein complement(1713207..1713428) Streptococcus pneumoniae 70585 7684797 YP_002741064.1 CDS SP70585_1845 NC_012468.1 1713482 1713781 R hypothetical protein complement(1713482..1713781) Streptococcus pneumoniae 70585 7685087 YP_002741065.1 CDS SP70585_1846 NC_012468.1 1715107 1716426 R identified by match to protein family HMM PF00251; match to protein family HMM TIGR01322; sucrose-6-phosphate hydrolase complement(1715107..1716426) Streptococcus pneumoniae 70585 7684478 YP_002741066.1 CDS SP70585_1847 NC_012468.1 1716436 1717281 R identified by match to protein family HMM PF00528; sugar ABC transporter permease complement(1716436..1717281) Streptococcus pneumoniae 70585 7683152 YP_002741067.1 CDS SP70585_1848 NC_012468.1 1717283 1718185 R identified by match to protein family HMM PF00528; ABC transporter permease complement(1717283..1718185) Streptococcus pneumoniae 70585 7683887 YP_002741068.1 CDS SP70585_1849 NC_012468.1 1718281 1719591 R identified by match to protein family HMM PF01547; sugar ABC transporter substrate-binding protein complement(1718281..1719591) Streptococcus pneumoniae 70585 7683975 YP_002741069.1 CDS SP70585_1850 NC_012468.1 1719718 1720713 R identified by match to protein family HMM PF00356; match to protein family HMM PF00532; sugar-binding transcriptional regulator, LacI family protein complement(1719718..1720713) Streptococcus pneumoniae 70585 7684614 YP_002741070.1 CDS SP70585_1851 NC_012468.1 1721075 1722556 R identified by match to protein family HMM PF05043; match to protein family HMM PF08270; match to protein family HMM PF08279; match to protein family HMM PF08280; M protein trans-acting positive transcriptional regulator complement(1721075..1722556) Streptococcus pneumoniae 70585 7684265 YP_002741071.1 CDS SP70585_1852 NC_012468.1 1722967 1723164 D identified by match to protein family HMM PF04226; hypothetical protein 1722967..1723164 Streptococcus pneumoniae 70585 7684044 YP_002741072.1 CDS SP70585_1853 NC_012468.1 1723248 1723814 D hypothetical protein 1723248..1723814 Streptococcus pneumoniae 70585 7684606 YP_002741073.1 CDS SP70585_1854 NC_012468.1 1723826 1723996 D lipoprotein, putative 1723826..1723996 Streptococcus pneumoniae 70585 7683699 YP_002741074.1 CDS SP70585_1855 NC_012468.1 1724035 1724643 D identified by match to protein family HMM PF03780; Gls24 protein 1724035..1724643 Streptococcus pneumoniae 70585 7683202 YP_002741075.1 CDS SP70585_1856 NC_012468.1 1724674 1724877 D identified by match to protein family HMM PF05532; hypothetical protein 1724674..1724877 Streptococcus pneumoniae 70585 7685198 YP_002741076.1 CDS SP70585_1857 NC_012468.1 1724987 1725226 R hypothetical protein complement(1724987..1725226) Streptococcus pneumoniae 70585 7684170 YP_002741077.1 CDS SP70585_1858 NC_012468.1 1725691 1725810 R identified by glimmer; putative; hypothetical protein complement(1725691..1725810) Streptococcus pneumoniae 70585 7684173 YP_002741078.1 CDS SP70585_1859 NC_012468.1 1726028 1726798 R identified by match to protein family HMM PF01925; hypothetical protein complement(1726028..1726798) Streptococcus pneumoniae 70585 7684768 YP_002741079.1 CDS SP70585_1860 NC_012468.1 1726813 1727661 R identified by match to protein family HMM PF03781; sulfatase-modifying factor 1 (C-alpha-formyglycine-generating enzyme 1) complement(1726813..1727661) Streptococcus pneumoniae 70585 7683304 YP_002741080.1 CDS SP70585_1861 NC_012468.1 1727658 1729133 R can hydrolyze p-nitrophenyl sulfate; contains a specific cysteine that is converted into C{alpha]-formylglycine upon activation with the anaerobic sulfatase-maturase; arylsulfatase complement(1727658..1729133) Streptococcus pneumoniae 70585 7684112 YP_002741081.1 CDS SP70585_1862 NC_012468.1 1729456 1730811 R identified by match to protein family HMM PF02378; match to protein family HMM TIGR00410; phosphotransferase system complement(1729456..1730811) Streptococcus pneumoniae 70585 7685022 YP_002741082.1 CDS SP70585_1863 NC_012468.1 1730821 1731138 R identified by match to protein family HMM PF02255; lichenan-specific phosphotransferase enzyme iia component (pts system lichenan-specific eiia component) (eiia-lic) (eiii-lic) complement(1730821..1731138) Streptococcus pneumoniae 70585 7684866 YP_002741083.1 CDS SP70585_1864 NC_012468.1 1731155 1731472 R identified by match to protein family HMM PF02302; lichenan-specific phosphotransferase enzyme iib component (pts system lichenan-specific eiib component) (eiib-lic) complement(1731155..1731472) Streptococcus pneumoniae 70585 7684144 YP_002741084.1 CDS SP70585_1865 NC_012468.1 1731487 1732383 R hypothetical protein complement(1731487..1732383) Streptococcus pneumoniae 70585 7684000 YP_002741085.1 CDS SP70585_1866 NC_012468.1 1732386 1733648 R identified by match to protein family HMM PF02378; match to protein family HMM TIGR00410; lichenan permease iic component (pts system lichenan-specific eiiccomponent) (eiic-lic) complement(1732386..1733648) Streptococcus pneumoniae 70585 7683212 YP_002741086.1 CDS SP70585_1867 NC_012468.1 1733928 1735106 D identified by match to protein family HMM PF00480; ROK family protein, putative 1733928..1735106 Streptococcus pneumoniae 70585 7684776 YP_002741087.1 CDS SP70585_1868 NC_012468.1 1735334 1735780 R identified by match to protein family HMM PF00583; acetyltransferase, gnat family complement(1735334..1735780) Streptococcus pneumoniae 70585 7683717 YP_002741088.1 CDS SP70585_1869 NC_012468.1 1735850 1736509 D identified by match to protein family HMM PF01478; match to protein family HMM PF06750; type 4 prepilin peptidase 1735850..1736509 Streptococcus pneumoniae 70585 7684153 YP_002741089.1 CDS SP70585_1870 NC_012468.1 1736561 1737712 R identified by match to protein family HMM PF01381; match to protein family HMM PF06114; transcriptional regulator complement(1736561..1737712) Streptococcus pneumoniae 70585 7683015 YP_002741090.1 CDS SP70585_1871 NC_012468.1 1737727 1738458 R hypothetical protein complement(1737727..1738458) Streptococcus pneumoniae 70585 7684185 YP_002741091.1 CDS trpA NC_012468.1 1738760 1739536 R catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha complement(1738760..1739536) Streptococcus pneumoniae 70585 7685081 YP_002741092.1 CDS trpB NC_012468.1 1739529 1740752 R catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta complement(1739529..1740752) Streptococcus pneumoniae 70585 7684504 YP_002741093.1 CDS trpF NC_012468.1 1740730 1741329 R catalyzes the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)-anthranilate in tryptophan biosynthesis; N-(5'-phosphoribosyl)anthranilate isomerase complement(1740730..1741329) Streptococcus pneumoniae 70585 7683226 YP_002741094.1 CDS trpC NC_012468.1 1741316 1742083 R involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water; indole-3-glycerol-phosphate synthase complement(1741316..1742083) Streptococcus pneumoniae 70585 7684373 YP_002741095.1 CDS trpD NC_012468.1 1742080 1743084 R Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate; anthranilate phosphoribosyltransferase complement(1742080..1743084) Streptococcus pneumoniae 70585 7685107 YP_002741096.1 CDS SP70585_1877 NC_012468.1 1743095 1743661 R TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity; anthranilate synthase component II complement(1743095..1743661) Streptococcus pneumoniae 70585 7684785 YP_002741097.1 CDS trpE NC_012468.1 1743658 1745019 R with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I complement(1743658..1745019) Streptococcus pneumoniae 70585 7684666 YP_002741098.1 CDS SP70585_1879 NC_012468.1 1745154 1745309 R hypothetical protein complement(1745154..1745309) Streptococcus pneumoniae 70585 7683070 YP_002741099.1 CDS SP70585_1880 NC_012468.1 1745313 1745432 R hypothetical protein complement(1745313..1745432) Streptococcus pneumoniae 70585 7684629 YP_002741100.1 CDS SP70585_1881 NC_012468.1 1745392 1745598 R chlorohydrolase complement(1745392..1745598) Streptococcus pneumoniae 70585 7682928 YP_002741101.1 CDS SP70585_1882 NC_012468.1 1746206 1747207 R identified by match to protein family HMM PF00356; match to protein family HMM PF00532; catabolite control protein complement(1746206..1747207) Streptococcus pneumoniae 70585 7683270 YP_002741102.1 CDS SP70585_1883 NC_012468.1 1747779 1748489 R identified by match to protein family HMM PF02308; putative Mg2+ transporter-C (MgtC) family protein complement(1747779..1748489) Streptococcus pneumoniae 70585 7683456 YP_002741103.1 CDS SP70585_1884 NC_012468.1 1748492 1750183 R identified by match to protein family HMM PF00528; binding-protein-dependent transport systems inner membrane component complement(1748492..1750183) Streptococcus pneumoniae 70585 7683629 YP_002741104.1 CDS SP70585_1885 NC_012468.1 1750195 1751205 R identified by match to protein family HMM PF00005; match to protein family HMM PF03459; match to protein family HMM PF08402; spermidine/putrescine import ATP-binding protein PotA complement(1750195..1751205) Streptococcus pneumoniae 70585 7684620 YP_002741105.1 CDS SP70585_1886 NC_012468.1 1751308 1752375 R ABC transporter substrate-binding protein complement(1751308..1752375) Streptococcus pneumoniae 70585 7684944 YP_002741106.1 CDS SP70585_1887 NC_012468.1 1752400 1753059 R identified by match to protein family HMM PF08975; hypothetical protein complement(1752400..1753059) Streptococcus pneumoniae 70585 7684384 YP_002741107.1 CDS SP70585_1888 NC_012468.1 1753170 1753283 R hypothetical protein complement(1753170..1753283) Streptococcus pneumoniae 70585 7684694 YP_002741108.1 CDS SP70585_1889 NC_012468.1 1753784 1754080 R hypothetical protein complement(1753784..1754080) Streptococcus pneumoniae 70585 7685053 YP_002741109.1 CDS SP70585_1890 NC_012468.1 1754064 1756190 R identified by match to protein family HMM PF04650; match to protein family HMM TIGR01168; cell wall surface anchor family protein complement(1754064..1756190) Streptococcus pneumoniae 70585 7684461 YP_002741110.1 CDS SP70585_1891 NC_012468.1 1757354 1758580 R identified by match to protein family HMM PF01041; Cps7G complement(1757354..1758580) Streptococcus pneumoniae 70585 7684103 YP_002741111.1 CDS SP70585_1892 NC_012468.1 1758623 1759315 R identified by match to protein family HMM PF02397; sugar transferase family protein complement(1758623..1759315) Streptococcus pneumoniae 70585 7682968 YP_002741112.1 CDS SP70585_1893 NC_012468.1 1759489 1761240 R identified by match to protein family HMM PF00005; match to protein family HMM PF00664; ABC transporter ATP-binding protein complement(1759489..1761240) Streptococcus pneumoniae 70585 7684792 YP_002741113.1 CDS SP70585_1894 NC_012468.1 1761230 1762975 R identified by match to protein family HMM PF00005; match to protein family HMM PF00664; ABC transporter ATP-binding protein complement(1761230..1762975) Streptococcus pneumoniae 70585 7684906 YP_002741114.1 CDS SP70585_1895 NC_012468.1 1763181 1763477 R identified by match to protein family HMM PF04239; hypothetical protein complement(1763181..1763477) Streptococcus pneumoniae 70585 7684755 YP_002741115.1 CDS SP70585_1896 NC_012468.1 1763630 1763743 R identified by glimmer; putative; hypothetical protein complement(1763630..1763743) Streptococcus pneumoniae 70585 7684884 YP_002741116.1 CDS SP70585_1897 NC_012468.1 1763859 1764086 R identified by glimmer; putative; hypothetical protein complement(1763859..1764086) Streptococcus pneumoniae 70585 7684459 YP_002741117.1 CDS xth NC_012468.1 1764220 1765047 D identified by match to protein family HMM PF03372; match to protein family HMM TIGR00195; match to protein family HMM TIGR00633; exodeoxyribonuclease III 1764220..1765047 Streptococcus pneumoniae 70585 7683977 YP_002741118.1 CDS xpt NC_012468.1 1766319 1766900 D Catalyzes the transfer of the phosphoribosyl moiety from 5-phospho--D-ribosyl-1-pyrophosphate (PRib-PP) to the 6-oxo-guanine and -xanthine; xanthine phosphoribosyltransferase 1766319..1766900 Streptococcus pneumoniae 70585 7683351 YP_002741119.1 CDS SP70585_1902 NC_012468.1 1766900 1768162 D identified by match to protein family HMM PF00860; match to protein family HMM PF00916; match to protein family HMM TIGR00801; match to protein family HMM TIGR03173; xanthine permease 1766900..1768162 Streptococcus pneumoniae 70585 7683640 YP_002741120.1 CDS SP70585_1903 NC_012468.1 1768249 1769115 R identified by match to protein family HMM PF04556; type II restriction enzyme complement(1768249..1769115) Streptococcus pneumoniae 70585 7684367 YP_002741121.1 CDS SP70585_1904 NC_012468.1 1769102 1769872 R identified by match to protein family HMM PF01555; DNA methylase complement(1769102..1769872) Streptococcus pneumoniae 70585 7684257 YP_002741122.1 CDS SP70585_1905 NC_012468.1 1769898 1770785 R identified by match to protein family HMM PF02086; match to protein family HMM TIGR00571; modification methylase complement(1769898..1770785) Streptococcus pneumoniae 70585 7684135 YP_002741123.1 CDS SP70585_1906 NC_012468.1 1770909 1771313 R identified by match to protein family HMM PF03061; match to protein family HMM TIGR00369; thioesterase family protein complement(1770909..1771313) Streptococcus pneumoniae 70585 7683985 YP_002741124.1 CDS galT NC_012468.1 1771383 1772867 R catalyzes the formation of alpha-D-glucose 1-phosphate and UDP-galactose from UDP-glucose and alpha-D-galactose 1-phosphate in galactose metabolism; galactose-1-phosphate uridylyltransferase complement(1771383..1772867) Streptococcus pneumoniae 70585 7683577 YP_002741125.1 CDS galK NC_012468.1 1772883 1774061 R catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase complement(1772883..1774061) Streptococcus pneumoniae 70585 7683539 YP_002741126.1 CDS SP70585_1909 NC_012468.1 1774225 1775232 D identified by match to protein family HMM PF00356; match to protein family HMM PF00532; GalR, member of GalR-LacI family of transcriptional regulators, binds DNA; regulator of gal operon 1774225..1775232 Streptococcus pneumoniae 70585 7684486 YP_002741127.1 CDS SP70585_1910 NC_012468.1 1775279 1776316 R identified by match to protein family HMM PF00107; match to protein family HMM PF08240; alcohol dehydrogenase, zinc-containing complement(1775279..1776316) Streptococcus pneumoniae 70585 7683415 YP_002741128.1 CDS SP70585_1911 NC_012468.1 1776317 1776670 R identified by match to protein family HMM PF00376; transcriptional regulator, MerR family complement(1776317..1776670) Streptococcus pneumoniae 70585 7684812 YP_002741129.1 CDS SP70585_1912 NC_012468.1 1776914 1777804 R identified by match to protein family HMM PF01545; match to protein family HMM TIGR01297; cation diffusion facilitator transporter - heavy metal transport complement(1776914..1777804) Streptococcus pneumoniae 70585 7683076 YP_002741130.1 CDS SP70585_1913 NC_012468.1 1777937 1778473 D identified by match to protein family HMM PF00440; TetR family transcriptional regulator 1777937..1778473 Streptococcus pneumoniae 70585 7683198 YP_002741131.1 CDS SP70585_1914 NC_012468.1 1778639 1779445 R identified by match to protein family HMM PF04973; match to protein family HMM TIGR01528; nicotinamide mononucleotide transporter complement(1778639..1779445) Streptococcus pneumoniae 70585 7684021 YP_002741132.1 CDS SP70585_1915 NC_012468.1 1779616 1779732 R identified by glimmer; putative; hypothetical protein complement(1779616..1779732) Streptococcus pneumoniae 70585 7683601 YP_002741133.1 CDS SP70585_1916 NC_012468.1 1779790 1781310 R identified by match to protein family HMM PF00528; match to protein family HMM PF04069; choline transporter complement(1779790..1781310) Streptococcus pneumoniae 70585 7683653 YP_002741134.1 CDS SP70585_1917 NC_012468.1 1781303 1782031 R identified by match to protein family HMM PF00005; choline transport ATP-binding protein opuBA complement(1781303..1782031) Streptococcus pneumoniae 70585 7683362 YP_002741135.1 CDS SP70585_1918 NC_012468.1 1782046 1782810 R identified by match to protein family HMM PF07366; hypothetical protein complement(1782046..1782810) Streptococcus pneumoniae 70585 7684557 YP_002741136.1 CDS SP70585_1919 NC_012468.1 1782814 1783257 R identified by match to protein family HMM PF01047; transcriptional regulator, MarR family complement(1782814..1783257) Streptococcus pneumoniae 70585 7684441 YP_002741137.1 CDS SP70585_1920 NC_012468.1 1783939 1784235 R hypothetical protein complement(1783939..1784235) Streptococcus pneumoniae 70585 7684006 YP_002741138.1 CDS pepA NC_012468.1 1784257 1785321 R identified by match to protein family HMM PF05343; match to protein family HMM TIGR03107; glutamyl aminopeptidase complement(1784257..1785321) Streptococcus pneumoniae 70585 7684383 YP_002741139.1 CDS SP70585_1922 NC_012468.1 1785441 1785563 D hypothetical protein 1785441..1785563 Streptococcus pneumoniae 70585 7685136 YP_002741140.1 CDS SP70585_1923 NC_012468.1 1785722 1786423 D identified by match to protein family HMM PF00106; match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF07993; UDP-glucose 4-epimerase (Galactowaldenase) (UDP-galactose4-epimerase) 1785722..1786423 Streptococcus pneumoniae 70585 7684795 YP_002741141.1 CDS SP70585_1924 NC_012468.1 1786846 1787805 D identified by match to protein family HMM PF01032; iron-compound ABC transporter permease 1786846..1787805 Streptococcus pneumoniae 70585 7683877 YP_002741142.1 CDS SP70585_1925 NC_012468.1 1787795 1788751 D identified by match to protein family HMM PF01032; iron-compound ABC transporter permease 1787795..1788751 Streptococcus pneumoniae 70585 7682976 YP_002741143.1 CDS SP70585_1926 NC_012468.1 1788748 1789500 D identified by match to protein family HMM PF00005; ferrichrome transport ATP-binding protein FhuC 1788748..1789500 Streptococcus pneumoniae 70585 7683161 YP_002741144.1 CDS SP70585_1927 NC_012468.1 1789596 1790561 D identified by match to protein family HMM PF01497; iron-compound ABC transporter iron-compound-binding protein 1789596..1790561 Streptococcus pneumoniae 70585 7685078 YP_002741145.1 CDS SP70585_1928 NC_012468.1 1790786 1791028 R identified by match to protein family HMM PF01809; match to protein family HMM TIGR00278; hypothetical protein complement(1790786..1791028) Streptococcus pneumoniae 70585 7684332 YP_002741146.1 CDS rluB NC_012468.1 1791028 1791750 R identified by match to protein family HMM PF00849; match to protein family HMM PF01479; match to protein family HMM TIGR00093; ribosomal large subunit pseudouridine synthase B complement(1791028..1791750) Streptococcus pneumoniae 70585 7684579 YP_002741147.1 CDS scpB NC_012468.1 1791737 1792306 R functions during chromosome segregation; may form a condensin-like structure with SMC and ScpA; forms a homodimer; segregation and condensation protein B complement(1791737..1792306) Streptococcus pneumoniae 70585 7683654 YP_002741148.1 CDS scpA NC_012468.1 1792325 1793053 R functions during chromosome segregation; may form a condensin-like structure with SMC and ScpB; segregation and condensation protein A complement(1792325..1793053) Streptococcus pneumoniae 70585 7684857 YP_002741149.1 CDS xerD NC_012468.1 1793053 1793793 R site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD-like protein complement(1793053..1793793) Streptococcus pneumoniae 70585 7684858 YP_002741150.1 CDS SP70585_1933 NC_012468.1 1793784 1794245 R identified by match to protein family HMM PF00571; CBS domain protein complement(1793784..1794245) Streptococcus pneumoniae 70585 7683860 YP_002741151.1 CDS SP70585_1934 NC_012468.1 1794242 1794763 R identified by match to protein family HMM PF00149; match to protein family HMM TIGR00040; phosphodiesterase, family complement(1794242..1794763) Streptococcus pneumoniae 70585 7684650 YP_002741152.1 CDS SP70585_1935 NC_012468.1 1794739 1795710 R HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; deoxyribonucleotide triphosphate pyrophosphatase/hypothetical protein complement(1794739..1795710) Streptococcus pneumoniae 70585 7685128 YP_002741153.1 CDS murI NC_012468.1 1795707 1796501 R converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase complement(1795707..1796501) Streptococcus pneumoniae 70585 7683751 YP_002741154.1 CDS SP70585_1937 NC_012468.1 1796708 1796956 R identified by match to protein family HMM PF03672; hypothetical protein complement(1796708..1796956) Streptococcus pneumoniae 70585 7684485 YP_002741155.1 CDS treC NC_012468.1 1797212 1798837 R identified by match to protein family HMM PF00128; match to protein family HMM TIGR02403; alpha,alpha-phosphotrehalase complement(1797212..1798837) Streptococcus pneumoniae 70585 7684243 YP_002741156.1 CDS treP NC_012468.1 1799015 1800982 R identified by match to protein family HMM PF00358; match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826; match to protein family HMM TIGR00830; match to protein family HMM TIGR01992; pts system, trehalose-specific iibc component complement(1799015..1800982) Streptococcus pneumoniae 70585 7684853 YP_002741157.1 CDS treR NC_012468.1 1801167 1801877 D identified by match to protein family HMM PF00392; match to protein family HMM PF07702; match to protein family HMM TIGR02404; trehalose operon repressor 1801167..1801877 Streptococcus pneumoniae 70585 7683935 YP_002741158.1 CDS SP70585_1941 NC_012468.1 1802033 1802551 D an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase 1802033..1802551 Streptococcus pneumoniae 70585 7684115 YP_002741159.1 CDS SP70585_1942 NC_012468.1 1802542 1803318 D an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01610; transposase 1802542..1803318 Streptococcus pneumoniae 70585 7682951 YP_002741160.1 CDS SP70585_1943 NC_012468.1 1803417 1804199 D an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF01610; transposase 1803417..1804199 Streptococcus pneumoniae 70585 7683217 YP_002741161.1 CDS SP70585_1944 NC_012468.1 1804196 1804723 D an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase 1804196..1804723 Streptococcus pneumoniae 70585 7683503 YP_002741162.1 CDS SP70585_1945 NC_012468.1 1804857 1805783 R identified by match to protein family HMM PF00005; match to protein family HMM PF08352; oligopeptide transport ATP-binding protein AmiF complement(1804857..1805783) Streptococcus pneumoniae 70585 7684469 YP_002741163.1 CDS SP70585_1946 NC_012468.1 1805794 1806861 R identified by match to protein family HMM PF00005; match to protein family HMM PF08352; match to protein family HMM TIGR01727; oligopeptide transport ATP-binding protein OppD complement(1805794..1806861) Streptococcus pneumoniae 70585 7684070 YP_002741164.1 CDS SP70585_1947 NC_012468.1 1806870 1807796 R identified by match to protein family HMM PF00528; oligopeptide transport system permease AmiD complement(1806870..1807796) Streptococcus pneumoniae 70585 7684166 YP_002741165.1 CDS SP70585_1948 NC_012468.1 1807796 1809292 R identified by match to protein family HMM PF00528; oligopeptide transport system permease AmiC complement(1807796..1809292) Streptococcus pneumoniae 70585 7682878 YP_002741166.1 CDS SP70585_1949 NC_012468.1 1809359 1811338 R identified by match to protein family HMM PF00496; AmiA protein complement(1809359..1811338) Streptococcus pneumoniae 70585 7684687 YP_002741167.1 CDS SP70585_1950 NC_012468.1 1812024 1813217 R identified by match to protein family HMM PF04932; O-antigen polymerase family complement(1812024..1813217) Streptococcus pneumoniae 70585 7683039 YP_002741168.1 CDS SP70585_1951 NC_012468.1 1813355 1814797 R identified by match to protein family HMM PF00128; sucrose phosphorylase (Sucrose glucosyltransferase)(Glucosyltransferase-A) (GTF-A) complement(1813355..1814797) Streptococcus pneumoniae 70585 7683465 YP_002741169.1 CDS SP70585_1952 NC_012468.1 1814800 1815009 R chlorohydrolase complement(1814800..1815009) Streptococcus pneumoniae 70585 7684953 YP_002741170.1 CDS SP70585_1953 NC_012468.1 1815016 1815849 R identified by match to protein family HMM PF00528; sugar ABC transporter permease complement(1815016..1815849) Streptococcus pneumoniae 70585 7684035 YP_002741171.1 CDS SP70585_1954 NC_012468.1 1815863 1816729 R identified by match to protein family HMM PF00528; sugar ABC transporter permease complement(1815863..1816729) Streptococcus pneumoniae 70585 7684637 YP_002741172.1 CDS SP70585_1955 NC_012468.1 1816743 1818002 R identified by match to protein family HMM PF01547; sugar ABC transporter substrate-binding protein complement(1816743..1818002) Streptococcus pneumoniae 70585 7683078 YP_002741173.1 CDS SP70585_1956 NC_012468.1 1818037 1820199 R identified by match to protein family HMM PF02065; alpha-galactosidase AgaN complement(1818037..1820199) Streptococcus pneumoniae 70585 7683429 YP_002741174.1 CDS SP70585_1957 NC_012468.1 1820307 1821167 D identified by match to protein family HMM PF00165; match to protein family HMM PF02311; Msm operon regulatory protein 1820307..1821167 Streptococcus pneumoniae 70585 7683068 YP_002741175.1 CDS SP70585_1958 NC_012468.1 1821164 1822099 D catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; biotin--protein ligase 1821164..1822099 Streptococcus pneumoniae 70585 7684019 YP_002741176.1 CDS SP70585_1959 NC_012468.1 1822350 1822787 D transposase 1822350..1822787 Streptococcus pneumoniae 70585 7684709 YP_002741177.1 CDS rumA2 NC_012468.1 1829703 1831058 R identified by match to protein family HMM PF01938; match to protein family HMM PF05958; match to protein family HMM TIGR00479; 23S rRNA (uracil-5-)-methyltransferase RumA complement(1829703..1831058) Streptococcus pneumoniae 70585 7684318 YP_002741178.1 CDS recX NC_012468.1 1831096 1831872 D binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 1831096..1831872 Streptococcus pneumoniae 70585 7684334 YP_002741179.1 CDS SP70585_1984 NC_012468.1 1831961 1832494 D identified by match to protein family HMM PF04167; hypothetical protein 1831961..1832494 Streptococcus pneumoniae 70585 7683507 YP_002741180.1 CDS SP70585_1985 NC_012468.1 1832934 1833260 R hypothetical protein complement(1832934..1833260) Streptococcus pneumoniae 70585 7683771 YP_002741181.1 CDS SP70585_1986 NC_012468.1 1833360 1833689 R hypothetical protein complement(1833360..1833689) Streptococcus pneumoniae 70585 7683387 YP_002741182.1 CDS groEL NC_012468.1 1833827 1835449 R 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; chaperonin GroEL complement(1833827..1835449) Streptococcus pneumoniae 70585 7685164 YP_002741183.1 CDS groES NC_012468.1 1835465 1835749 R 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES complement(1835465..1835749) Streptococcus pneumoniae 70585 7684960 YP_002741184.1 CDS SP70585_1989 NC_012468.1 1836019 1836414 R binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein complement(1836019..1836414) Streptococcus pneumoniae 70585 7683366 YP_002741185.1 CDS SP70585_1990 NC_012468.1 1836492 1837253 R identified by match to protein family HMM PF00106; match to protein family HMM PF08659; oxidoreductase, short chain dehydrogenase/reductase family complement(1836492..1837253) Streptococcus pneumoniae 70585 7684468 YP_002741186.1 CDS SP70585_1991 NC_012468.1 1837286 1837912 R identified by match to protein family HMM PF01588; Putative tRNA binding domain protein complement(1837286..1837912) Streptococcus pneumoniae 70585 7683490 YP_002741187.1 CDS SP70585_1992 NC_012468.1 1837928 1838245 R identified by match to protein family HMM PF00085; thioredoxin family protein complement(1837928..1838245) Streptococcus pneumoniae 70585 7684955 YP_002741188.1 CDS SP70585_1993 NC_012468.1 1838242 1838541 R hypothetical protein complement(1838242..1838541) Streptococcus pneumoniae 70585 7684164 YP_002741189.1 CDS SP70585_1994 NC_012468.1 1838826 1838969 R identified by match to protein family HMM PF01473; hypothetical protein complement(1838826..1838969) Streptococcus pneumoniae 70585 7683999 YP_002741190.1 CDS SP70585_1995 NC_012468.1 1839178 1839852 R hypothetical protein complement(1839178..1839852) Streptococcus pneumoniae 70585 7683235 YP_002741191.1 CDS SP70585_1996 NC_012468.1 1839857 1840303 R identified by match to protein family HMM PF04397; response regulator of the LytR/AlgR family complement(1839857..1840303) Streptococcus pneumoniae 70585 7682893 YP_002741192.1 CDS SP70585_1997 NC_012468.1 1840417 1840920 R identified by match to protein family HMM PF01569; PAP2 family protein complement(1840417..1840920) Streptococcus pneumoniae 70585 7684623 YP_002741193.1 CDS SP70585_1998 NC_012468.1 1840917 1841279 R hypothetical protein complement(1840917..1841279) Streptococcus pneumoniae 70585 7683982 YP_002741194.1 CDS SP70585_1999 NC_012468.1 1841345 1842376 R identified by match to protein family HMM PF00005; ABC transporter permease complement(1841345..1842376) Streptococcus pneumoniae 70585 7684041 YP_002741195.1 CDS SP70585_2000 NC_012468.1 1842383 1843204 R identified by match to protein family HMM PF00664; ABC transporter permease complement(1842383..1843204) Streptococcus pneumoniae 70585 7683725 YP_002741196.1 CDS SP70585_2001 NC_012468.1 1843243 1843569 R identified by match to protein family HMM PF01047; transcriptional regulator, MarR family complement(1843243..1843569) Streptococcus pneumoniae 70585 7683237 YP_002741197.1 CDS SP70585_2002 NC_012468.1 1843816 1844532 R identified by match to protein family HMM PF01709; match to protein family HMM TIGR01033; hypothetical protein complement(1843816..1844532) Streptococcus pneumoniae 70585 7683770 YP_002741198.1 CDS SP70585_2003 NC_012468.1 1845413 1846828 R identified by match to protein family HMM PF01289; pneumolysin (Thiol-activated cytolysin) complement(1845413..1846828) Streptococcus pneumoniae 70585 7683407 YP_002741199.1 CDS SP70585_2004 NC_012468.1 1846839 1847249 R hypothetical protein complement(1846839..1847249) Streptococcus pneumoniae 70585 7685047 YP_002741200.1 CDS SP70585_2005 NC_012468.1 1847242 1847850 R hypothetical protein complement(1847242..1847850) Streptococcus pneumoniae 70585 7684232 YP_002741201.1 CDS SP70585_2006 NC_012468.1 1847863 1848321 R identified by glimmer; putative; hypothetical protein complement(1847863..1848321) Streptococcus pneumoniae 70585 7683579 YP_002741202.1 CDS SP70585_2007 NC_012468.1 1848446 1848577 D mobile genetic element 1848446..1848577 Streptococcus pneumoniae 70585 7683939 YP_002741203.1 CDS SP70585_2008 NC_012468.1 1848582 1848908 D mobile genetic element 1848582..1848908 Streptococcus pneumoniae 70585 7684132 YP_002741204.1 CDS SP70585_2009 NC_012468.1 1849568 1849828 R hypothetical protein complement(1849568..1849828) Streptococcus pneumoniae 70585 7682995 YP_002741205.1 CDS SP70585_2010 NC_012468.1 1849887 1850438 R hypothetical protein complement(1849887..1850438) Streptococcus pneumoniae 70585 7683660 YP_002741206.1 CDS SP70585_2011 NC_012468.1 1850428 1850625 R hypothetical protein complement(1850428..1850625) Streptococcus pneumoniae 70585 7685055 YP_002741207.1 CDS SP70585_2012 NC_012468.1 1850629 1851213 R hypothetical protein complement(1850629..1851213) Streptococcus pneumoniae 70585 7683843 YP_002741208.1 CDS SP70585_2013 NC_012468.1 1851621 1852046 R hypothetical protein complement(1851621..1852046) Streptococcus pneumoniae 70585 7683780 YP_002741209.1 CDS SP70585_2014 NC_012468.1 1852175 1852534 R hypothetical protein complement(1852175..1852534) Streptococcus pneumoniae 70585 7683436 YP_002741210.1 CDS SP70585_2015 NC_012468.1 1852773 1852934 R type II restriction-modification system regulatory protein, putative complement(1852773..1852934) Streptococcus pneumoniae 70585 7683719 YP_002741211.1 CDS SP70585_2016 NC_012468.1 1853293 1854249 R identified by match to protein family HMM PF01473; match to protein family HMM PF01510; autolysin (N-acetylmuramoyl-L-alanine amidase) (Mureinhydrolase) (Mucopeptide aminohydrolase) (Cell wall hydrolase) complement(1853293..1854249) Streptococcus pneumoniae 70585 7684815 YP_002741212.1 CDS SP70585_2017 NC_012468.1 1854377 1854490 R hypothetical protein complement(1854377..1854490) Streptococcus pneumoniae 70585 7683759 YP_002741213.1 CDS SP70585_2018 NC_012468.1 1854625 1855995 R identified by match to protein family HMM PF01554; match to protein family HMM TIGR00797; DNA-damage-inducible protein complement(1854625..1855995) Streptococcus pneumoniae 70585 7683425 YP_002741214.1 CDS recA NC_012468.1 1856302 1857468 R catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A complement(1856302..1857468) Streptococcus pneumoniae 70585 7684910 YP_002741215.1 CDS SP70585_2020 NC_012468.1 1857523 1858779 R identified by match to protein family HMM PF00994; match to protein family HMM PF02464; match to protein family HMM TIGR00199; match to protein family HMM TIGR00200; competence damage-inducible protein A complement(1857523..1858779) Streptococcus pneumoniae 70585 7684072 YP_002741216.1 CDS SP70585_2021 NC_012468.1 1858864 1859880 R identified by match to protein family HMM PF03816; match to protein family HMM TIGR00350; regulator of lytrabc operon complement(1858864..1859880) Streptococcus pneumoniae 70585 7684601 YP_002741217.1 CDS SP70585_2022 NC_012468.1 1859888 1860406 R identified by match to protein family HMM PF00583; acetyltransferase, gnat family complement(1859888..1860406) Streptococcus pneumoniae 70585 7684339 YP_002741218.1 CDS SP70585_2023 NC_012468.1 1860396 1860839 R identified by match to protein family HMM PF02367; match to protein family HMM TIGR00150; hypothetical protein complement(1860396..1860839) Streptococcus pneumoniae 70585 7683354 YP_002741219.1 CDS SP70585_2024 NC_012468.1 1860926 1861546 R lipoprotein, putative complement(1860926..1861546) Streptococcus pneumoniae 70585 7684413 YP_002741220.1 CDS SP70585_2025 NC_012468.1 1861929 1862792 R identified by match to protein family HMM PF01381; transcriptional activator complement(1861929..1862792) Streptococcus pneumoniae 70585 7682969 YP_002741221.1 CDS SP70585_2026 NC_012468.1 1862981 1863151 D hypothetical protein 1862981..1863151 Streptococcus pneumoniae 70585 7683868 YP_002741222.1 CDS SP70585_2027 NC_012468.1 1863296 1865311 D identified by match to protein family HMM PF07242; match to protein family HMM TIGR01654; bacteriocin-associated integral membrane protein 1863296..1865311 Streptococcus pneumoniae 70585 7684642 YP_002741223.1 CDS SP70585_2028 NC_012468.1 1865313 1865945 D identified by match to protein family HMM PF00005; antimicrobial peptide ABC transporter ATPase 1865313..1865945 Streptococcus pneumoniae 70585 7683087 YP_002741224.1 CDS SP70585_2029 NC_012468.1 1866086 1866247 D hypothetical protein 1866086..1866247 Streptococcus pneumoniae 70585 7684514 YP_002741225.1 CDS ndk NC_012468.1 1866875 1867288 R catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase complement(1866875..1867288) Streptococcus pneumoniae 70585 7683532 YP_002741226.1 CDS rpoC NC_012468.1 1867399 1871076 R DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' complement(1867399..1871076) Streptococcus pneumoniae 70585 7684333 YP_002741227.1 CDS rpoB NC_012468.1 1871109 1874705 R DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta complement(1871109..1874705) Streptococcus pneumoniae 70585 7684245 YP_002741228.1 CDS SP70585_2034 NC_012468.1 1875208 1875327 R identified by glimmer; putative; hypothetical protein complement(1875208..1875327) Streptococcus pneumoniae 70585 7683911 YP_002741229.1 CDS SP70585_2035 NC_012468.1 1875389 1876720 R identified by match to protein family HMM PF00571; match to protein family HMM PF01595; match to protein family HMM PF03471; hemolysin complement(1875389..1876720) Streptococcus pneumoniae 70585 7683952 YP_002741230.1 CDS SP70585_2036 NC_012468.1 1876949 1877773 R identified by match to protein family HMM PF01223; DNA-entry nuclease (Competence-specific nuclease) complement(1876949..1877773) Streptococcus pneumoniae 70585 7683544 YP_002741231.1 CDS SP70585_2037 NC_012468.1 1877812 1878000 R hypothetical protein complement(1877812..1878000) Streptococcus pneumoniae 70585 7684209 YP_002741232.1 CDS murA2 NC_012468.1 1877993 1879276 R adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase complement(1877993..1879276) Streptococcus pneumoniae 70585 7683314 YP_002741233.1 CDS SP70585_2039 NC_012468.1 1879300 1879431 R hypothetical protein complement(1879300..1879431) Streptococcus pneumoniae 70585 7684411 YP_002741234.1 CDS SP70585_2040 NC_012468.1 1879588 1880625 R ATP-dependent protease La complement(1879588..1880625) Streptococcus pneumoniae 70585 7683261 YP_002741235.1 CDS coaD NC_012468.1 1880609 1881097 R Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase complement(1880609..1881097) Streptococcus pneumoniae 70585 7683020 YP_002741236.1 CDS SP70585_2042 NC_012468.1 1881087 1881626 R identified by match to protein family HMM PF03602; N6-adenine-specific methylase complement(1881087..1881626) Streptococcus pneumoniae 70585 7684656 YP_002741237.1 CDS asnA NC_012468.1 1881691 1882683 R catalyzes the formation of asparagine from aspartate and ammonia; asparagine synthetase AsnA complement(1881691..1882683) Streptococcus pneumoniae 70585 7685059 YP_002741238.1 CDS SP70585_2044 NC_012468.1 1882795 1883478 R identified by match to protein family HMM PF01027; membrane protein complement(1882795..1883478) Streptococcus pneumoniae 70585 7684698 YP_002741239.1 CDS SP70585_2045 NC_012468.1 1883534 1884274 R identified by match to protein family HMM PF00588; match to protein family HMM PF08032; rRNA/tRNA methylase complement(1883534..1884274) Streptococcus pneumoniae 70585 7682962 YP_002741240.1 CDS SP70585_2046 NC_012468.1 1884308 1884586 D catalyzes the hydrolysis of acylphosphate; acylphosphatase 1884308..1884586 Streptococcus pneumoniae 70585 7683199 YP_002741241.1 CDS SP70585_2047 NC_012468.1 1884664 1885590 D involved in biogenesis of membrane proteins; Firmicutes specific proteins are shorter than other bacterial counterparts and have a signal peptide and lipid attachment site; OxaA-like protein precursor 1884664..1885590 Streptococcus pneumoniae 70585 7683307 YP_002741242.1 CDS pflA NC_012468.1 1885665 1886459 R identified by match to protein family HMM PF04055; match to protein family HMM TIGR02493; pyruvate formate-lyase 1-activating enzyme complement(1885665..1886459) Streptococcus pneumoniae 70585 7684756 YP_002741243.1 CDS SP70585_2049 NC_012468.1 1886585 1887835 R identified by match to protein family HMM PF00278; match to protein family HMM PF02784; diaminopimelate decarboxylase complement(1886585..1887835) Streptococcus pneumoniae 70585 7684345 YP_002741244.1 CDS purR NC_012468.1 1887902 1888729 R identified by match to protein family HMM PF00156; match to protein family HMM PF09182; match to protein family HMM TIGR01743; pur operon repressor complement(1887902..1888729) Streptococcus pneumoniae 70585 7685044 YP_002741245.1 CDS SP70585_2051 NC_012468.1 1888996 1889937 R identified by match to protein family HMM PF01336; match to protein family HMM PF01966; 3'-5' exoribonuclease YhaM complement(1888996..1889937) Streptococcus pneumoniae 70585 7684692 YP_002741246.1 CDS SP70585_2052 NC_012468.1 1889927 1891183 R identified by match to protein family HMM PF02646; competence-induced protein Ccs50 complement(1889927..1891183) Streptococcus pneumoniae 70585 7684381 YP_002741247.1 CDS SP70585_2053 NC_012468.1 1891185 1891847 R identified by match to protein family HMM PF04263; match to protein family HMM PF04265; match to protein family HMM TIGR01378; thiamine pyrophosphokinase complement(1891185..1891847) Streptococcus pneumoniae 70585 7684791 YP_002741248.1 CDS rpe NC_012468.1 1891810 1892466 R identified by match to protein family HMM PF00834; match to protein family HMM TIGR01163; ribulose-phosphate 3-epimerase complement(1891810..1892466) Streptococcus pneumoniae 70585 7685139 YP_002741249.1 CDS rsgA NC_012468.1 1892477 1893355 R EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity; ribosome-associated GTPase complement(1892477..1893355) Streptococcus pneumoniae 70585 7684077 YP_002741250.1 CDS ksgA NC_012468.1 1893357 1894229 R catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase complement(1893357..1894229) Streptococcus pneumoniae 70585 7683668 YP_002741251.1 CDS SP70585_2057 NC_012468.1 1894480 1894773 R hypothetical protein complement(1894480..1894773) Streptococcus pneumoniae 70585 7683509 YP_002741252.1 CDS SP70585_2058 NC_012468.1 1894766 1895407 R identified by match to protein family HMM PF00005; antimicrobial peptide ABC transporter ATPase complement(1894766..1895407) Streptococcus pneumoniae 70585 7683804 YP_002741253.1 CDS SP70585_2059 NC_012468.1 1895409 1897439 R identified by match to protein family HMM PF07242; match to protein family HMM TIGR01654; immunity protein, putative complement(1895409..1897439) Streptococcus pneumoniae 70585 7685165 YP_002741254.1 CDS SP70585_2060 NC_012468.1 1897516 1897812 R identified by match to protein family HMM TIGR01653; bacteriocin, lactococcin 972 family complement(1897516..1897812) Streptococcus pneumoniae 70585 7683954 YP_002741255.1 CDS SP70585_2061 NC_012468.1 1898132 1899031 R transcriptional activator complement(1898132..1899031) Streptococcus pneumoniae 70585 7684997 YP_002741256.1 CDS SP70585_2062 NC_012468.1 1899103 1899663 R identified by match to protein family HMM PF01751; match to protein family HMM TIGR00334; putative primase homolog complement(1899103..1899663) Streptococcus pneumoniae 70585 7684889 YP_002741257.1 CDS SP70585_2063 NC_012468.1 1899663 1900436 R identified by match to protein family HMM PF01026; match to protein family HMM TIGR00010; deoxyribonuclease TatD family complement(1899663..1900436) Streptococcus pneumoniae 70585 7684515 YP_002741258.1 CDS SP70585_2064 NC_012468.1 1900742 1901407 R identified by match to protein family HMM PF00746; match to protein family HMM TIGR01167; cell wall surface anchor family protein complement(1900742..1901407) Streptococcus pneumoniae 70585 7683477 YP_002741259.1 CDS rpmH NC_012468.1 1901670 1901804 R in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 complement(1901670..1901804) Streptococcus pneumoniae 70585 7684179 YP_002741260.1 CDS SP70585_2066 NC_012468.1 1901949 1903163 R broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase AlaT complement(1901949..1903163) Streptococcus pneumoniae 70585 7683334 YP_002741261.1 CDS SP70585_2067 NC_012468.1 1903319 1903612 R identified by glimmer; putative; hypothetical protein complement(1903319..1903612) Streptococcus pneumoniae 70585 7684523 YP_002741262.1 CDS SP70585_2068 NC_012468.1 1903774 1904226 D identified by match to protein family HMM PF00582; universal stress protein family 1903774..1904226 Streptococcus pneumoniae 70585 7683392 YP_002741263.1 CDS SP70585_2069 NC_012468.1 1904261 1905649 R identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM PF08282; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; Cof family protein complement(1904261..1905649) Streptococcus pneumoniae 70585 7684597 YP_002741264.1 CDS SP70585_2070 NC_012468.1 1905715 1906677 D identified by match to protein family HMM PF00710; L-asparaginase 1905715..1906677 Streptococcus pneumoniae 70585 7685014 YP_002741265.1 CDS SP70585_2071 NC_012468.1 1906706 1907044 R identified by glimmer; putative; hypothetical protein complement(1906706..1907044) Streptococcus pneumoniae 70585 7683817 YP_002741266.1 CDS ccpA NC_012468.1 1907108 1908118 R identified by match to protein family HMM PF00356; match to protein family HMM PF00532; match to protein family HMM TIGR01481; catabolite control protein A complement(1907108..1908118) Streptococcus pneumoniae 70585 7683357 YP_002741267.1 CDS SP70585_2073 NC_012468.1 1908543 1909142 R identified by match to protein family HMM PF00072; match to protein family HMM PF00196; response regulator complement(1908543..1909142) Streptococcus pneumoniae 70585 7684422 YP_002741268.1 CDS SP70585_2074 NC_012468.1 1909144 1910241 R identified by match to protein family HMM PF02518; match to protein family HMM PF07730; histidine kinase complement(1909144..1910241) Streptococcus pneumoniae 70585 7684576 YP_002741269.1 CDS SP70585_2075 NC_012468.1 1910241 1910978 R identified by match to protein family HMM PF01061; multidrug ABC transporter permease complement(1910241..1910978) Streptococcus pneumoniae 70585 7684837 YP_002741270.1 CDS SP70585_2076 NC_012468.1 1910980 1911864 R identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein complement(1910980..1911864) Streptococcus pneumoniae 70585 7685141 YP_002741271.1 CDS SP70585_2077 NC_012468.1 1911851 1912045 R hypothetical protein complement(1911851..1912045) Streptococcus pneumoniae 70585 7684089 YP_002741272.1 CDS SP70585_2078 NC_012468.1 1912042 1912248 R hypothetical protein complement(1912042..1912248) Streptococcus pneumoniae 70585 7682965 YP_002741273.1 CDS SP70585_2093 NC_012468.1 1918928 1919407 R competence-specific global transcription modulator complement(1918928..1919407) Streptococcus pneumoniae 70585 7683909 YP_002741274.1 CDS nusG NC_012468.1 1919529 1920065 R Modulates Rho-dependent transcription termination; transcription antitermination protein NusG complement(1919529..1920065) Streptococcus pneumoniae 70585 7685185 YP_002741275.1 CDS secE NC_012468.1 1920120 1920296 R forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE complement(1920120..1920296) Streptococcus pneumoniae 70585 7684654 YP_002741276.1 CDS rpmG NC_012468.1 1920306 1920458 R in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group have the CXXC motif; 50S ribosomal protein L33 complement(1920306..1920458) Streptococcus pneumoniae 70585 7683088 YP_002741277.1 CDS SP70585_2097 NC_012468.1 1920511 1922706 R identified by match to protein family HMM PF00905; match to protein family HMM PF00912; match to protein family HMM TIGR02074; penicillin-binding protein 2A complement(1920511..1922706) Streptococcus pneumoniae 70585 7685067 YP_002741278.1 CDS SP70585_2098 NC_012468.1 1922832 1923668 D identified by match to protein family HMM PF00849; ribosomal large subunit pseudouridine synthase, RluD subfamily 1922832..1923668 Streptococcus pneumoniae 70585 7684152 YP_002741279.1 CDS gap NC_012468.1 1923736 1924743 R identified by match to protein family HMM PF00044; match to protein family HMM PF02800; match to protein family HMM TIGR01534; glyceraldehyde-3-phosphate dehydrogenase, type I complement(1923736..1924743) Streptococcus pneumoniae 70585 7683090 YP_002741280.1 CDS SP70585_2100 NC_012468.1 1924920 1925882 R identified by match to protein family HMM PF02687; efflux ABC transporter permease complement(1924920..1925882) Streptococcus pneumoniae 70585 7683468 YP_002741281.1 CDS SP70585_2101 NC_012468.1 1925943 1926125 R transposase complement(1925943..1926125) Streptococcus pneumoniae 70585 7683732 YP_002741282.1 CDS SP70585_2102 NC_012468.1 1926460 1926789 R identified by match to protein family HMM PF01710; transposase complement(1926460..1926789) Streptococcus pneumoniae 70585 7684037 YP_002741283.1 CDS nadC NC_012468.1 1926920 1927792 R catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; nicotinate-nucleotide pyrophosphorylase complement(1926920..1927792) Streptococcus pneumoniae 70585 7683623 YP_002741284.1 CDS SP70585_2104 NC_012468.1 1928029 1929339 D identified by match to protein family HMM PF03600; match to protein family HMM PF07158; membrane protein 1928029..1929339 Streptococcus pneumoniae 70585 7683625 YP_002741285.1 CDS SP70585_2105 NC_012468.1 1929705 1929836 R hypothetical protein complement(1929705..1929836) Streptococcus pneumoniae 70585 7684567 YP_002741286.1 CDS SP70585_2106 NC_012468.1 1930360 1931088 R identified by match to protein family HMM PF00392; match to protein family HMM PF07702; GntR family transcriptional regulator complement(1930360..1931088) Streptococcus pneumoniae 70585 7683859 YP_002741287.1 CDS SP70585_2107 NC_012468.1 1931246 1932655 D identified by match to protein family HMM PF00232; beta-glucosidase 1931246..1932655 Streptococcus pneumoniae 70585 7684865 YP_002741288.1 CDS SP70585_2108 NC_012468.1 1932673 1933968 D identified by match to protein family HMM PF02378; match to protein family HMM TIGR00410; phosphotransferase system system, cellobiose-specific IIC component 1932673..1933968 Streptococcus pneumoniae 70585 7684234 YP_002741289.1 CDS SP70585_2109 NC_012468.1 1933973 1934281 D identified by match to protein family HMM PF02302; lichenan-specific phosphotransferase enzyme iib component (pts system lichenan-specific eiib component) (eiib-lic) 1933973..1934281 Streptococcus pneumoniae 70585 7684034 YP_002741290.1 CDS SP70585_2110 NC_012468.1 1934278 1934586 D identified by match to protein family HMM PF02255; lichenan-specific phosphotransferase enzyme iia component (pts system lichenan-specific eiia component) (eiia-lic) (eiii-lic) 1934278..1934586 Streptococcus pneumoniae 70585 7683676 YP_002741291.1 CDS SP70585_2111 NC_012468.1 1935572 1938223 R identified by match to protein family HMM PF00465; bifunctional acetaldehyde-CoA/alcohol dehydrogenase complement(1935572..1938223) Streptococcus pneumoniae 70585 7682992 YP_002741292.1 CDS SP70585_2112 NC_012468.1 1938426 1938563 R hypothetical protein complement(1938426..1938563) Streptococcus pneumoniae 70585 7683535 YP_002741293.1 CDS SP70585_2113 NC_012468.1 1938523 1938933 R identified by match to protein family HMM PF02493; morn motif family protein complement(1938523..1938933) Streptococcus pneumoniae 70585 7683889 YP_002741294.1 CDS SP70585_2114 NC_012468.1 1938935 1939363 R identified by match to protein family HMM PF01451; phosphotyrosine protein phosphatase complement(1938935..1939363) Streptococcus pneumoniae 70585 7683424 YP_002741295.1 CDS yajC NC_012468.1 1939410 1939709 R member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC complement(1939410..1939709) Streptococcus pneumoniae 70585 7683641 YP_002741296.1 CDS tkt2 NC_012468.1 1939820 1941802 R catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase complement(1939820..1941802) Streptococcus pneumoniae 70585 7685012 YP_002741297.1 CDS SP70585_2117 NC_012468.1 1941916 1943007 R putative L-ascorbate 6-phosphate lactonase complement(1941916..1943007) Streptococcus pneumoniae 70585 7684534 YP_002741298.1 CDS SP70585_2118 NC_012468.1 1943119 1944792 R identified by match to protein family HMM PF00874; match to protein family HMM PF08279; transcriptional regulator, BglG family complement(1943119..1944792) Streptococcus pneumoniae 70585 7684022 YP_002741299.1 CDS araD NC_012468.1 1944969 1945673 R catalyzes the formation of D-xylulose 5-phosphate from L-ribulose 5-phosphate in the L-arabinose and L-ascorbate degradation pathways; L-ribulose-5-phosphate 4-epimerase complement(1944969..1945673) Streptococcus pneumoniae 70585 7684221 YP_002741300.1 CDS SP70585_2120 NC_012468.1 1945675 1946538 R L-xylulose 5-phosphate 3-epimerase activity not yet demonstrated; may be involved in the utilization of 2,3-diketo-L-gulonate; putative L-xylulose 5-phosphate 3-epimerase complement(1945675..1946538) Streptococcus pneumoniae 70585 7683452 YP_002741301.1 CDS ulaD NC_012468.1 1946542 1947207 R catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization; 3-keto-L-gulonate-6-phosphate decarboxylase complement(1946542..1947207) Streptococcus pneumoniae 70585 7684466 YP_002741302.1 CDS SP70585_2122 NC_012468.1 1947224 1947709 R identified by match to protein family HMM PF00359; ascorbate-specific phosphotransferase enzyme iia component (pts system ascorbate-specific eiia component) complement(1947224..1947709) Streptococcus pneumoniae 70585 7684455 YP_002741303.1 CDS SP70585_2123 NC_012468.1 1947786 1948067 R identified by match to protein family HMM PF02302; ascorbate-specific phosphotransferase enzyme iib component (ascorbate-specific pts system eiib component) complement(1947786..1948067) Streptococcus pneumoniae 70585 7683278 YP_002741304.1 CDS SP70585_2124 NC_012468.1 1948090 1949547 R membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC complement(1948090..1949547) Streptococcus pneumoniae 70585 7683037 YP_002741305.1 CDS SP70585_2125 NC_012468.1 1949678 1950301 R hypothetical protein complement(1949678..1950301) Streptococcus pneumoniae 70585 7683758 YP_002741306.1 CDS SP70585_2126 NC_012468.1 1950352 1951338 R identified by match to protein family HMM PF01424; jag protein complement(1950352..1951338) Streptococcus pneumoniae 70585 7683341 YP_002741307.1 CDS SP70585_2127 NC_012468.1 1951357 1952187 R identified by match to protein family HMM PF02096; membrane protein OxaA 1 complement(1951357..1952187) Streptococcus pneumoniae 70585 7683852 YP_002741308.1 CDS rnpA NC_012468.1 1952156 1952527 R protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P complement(1952156..1952527) Streptococcus pneumoniae 70585 7684767 YP_002741309.1 CDS SP70585_2129 NC_012468.1 1952544 1952675 R hypothetical protein complement(1952544..1952675) Streptococcus pneumoniae 70585 7683588 YP_002741310.1 CDS ackA NC_012468.1 1952676 1953866 R AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase complement(1952676..1953866) Streptococcus pneumoniae 70585 7683182 YP_002741311.1 CDS SP70585_2131 NC_012468.1 1953917 1954870 R adenine-specific DNA methylase complement(1953917..1954870) Streptococcus pneumoniae 70585 7685132 YP_002741312.1 CDS SP70585_2132 NC_012468.1 1955294 1955596 D an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; mobile genetic element 1955294..1955596 Streptococcus pneumoniae 70585 7684958 YP_002741313.1 CDS SP70585_2133 NC_012468.1 1955630 1955914 D an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; mobile genetic element 1955630..1955914 Streptococcus pneumoniae 70585 7682988 YP_002741314.1 CDS SP70585_2134 NC_012468.1 1956169 1956645 D identified by match to protein family HMM PF00583; acetyltransferase 1956169..1956645 Streptococcus pneumoniae 70585 7684829 YP_002741315.1 CDS SP70585_2135 NC_012468.1 1957300 1957713 R hypothetical protein complement(1957300..1957713) Streptococcus pneumoniae 70585 7683956 YP_002741316.1 CDS SP70585_2136 NC_012468.1 1957691 1958152 R competence protein ComGF complement(1957691..1958152) Streptococcus pneumoniae 70585 7683302 YP_002741317.1 CDS SP70585_2137 NC_012468.1 1958115 1958375 R hypothetical protein complement(1958115..1958375) Streptococcus pneumoniae 70585 7684739 YP_002741318.1 CDS SP70585_2138 NC_012468.1 1958380 1958766 R competence protein CglD complement(1958380..1958766) Streptococcus pneumoniae 70585 7684677 YP_002741319.1 CDS SP70585_2139 NC_012468.1 1958777 1959100 R identified by match to protein family HMM PF07963; match to protein family HMM TIGR02532; competence protein complement(1958777..1959100) Streptococcus pneumoniae 70585 7684045 YP_002741320.1 CDS SP70585_2140 NC_012468.1 1959102 1959950 R identified by match to protein family HMM PF00482; competence protein CglB complement(1959102..1959950) Streptococcus pneumoniae 70585 7683232 YP_002741321.1 CDS SP70585_2141 NC_012468.1 1960066 1961007 R identified by match to protein family HMM PF00437; putative ABC transporter subunit ComYA complement(1960066..1961007) Streptococcus pneumoniae 70585 7683091 YP_002741322.1 CDS SP70585_2142 NC_012468.1 1961083 1961448 R identified by match to protein family HMM PF06279; hypothetical protein complement(1961083..1961448) Streptococcus pneumoniae 70585 7683648 YP_002741323.1 CDS SP70585_2143 NC_012468.1 1961599 1962657 R identified by match to protein family HMM PF00107; match to protein family HMM PF08240; alcohol dehydrogenase, zinc-containing complement(1961599..1962657) Streptococcus pneumoniae 70585 7684429 YP_002741324.1 CDS nagA NC_012468.1 1962820 1963971 R identified by match to protein family HMM PF01979; match to protein family HMM TIGR00221; N-acetylglucosamine-6-phosphate deacetylase complement(1962820..1963971) Streptococcus pneumoniae 70585 7684933 YP_002741325.1 CDS SP70585_2145 NC_012468.1 1964124 1965941 R identified by match to protein family HMM PF01757; acyltransferase complement(1964124..1965941) Streptococcus pneumoniae 70585 7684874 YP_002741326.1 CDS SP70585_2147 NC_012468.1 1965934 1966059 D identified by glimmer; putative; hypothetical protein 1965934..1966059 Streptococcus pneumoniae 70585 7684218 YP_002741327.1 CDS tgt NC_012468.1 1966042 1967184 R Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase complement(1966042..1967184) Streptococcus pneumoniae 70585 7685042 YP_002741328.1 CDS SP70585_2148 NC_012468.1 1967314 1968171 D identified by match to protein family HMM PF06161; hypothetical protein 1967314..1968171 Streptococcus pneumoniae 70585 7684670 YP_002741329.1 CDS SP70585_2151 NC_012468.1 1968949 1969308 R identified by match to protein family HMM PF06993; hypothetical protein complement(1968949..1969308) Streptococcus pneumoniae 70585 7683019 YP_002741330.1 CDS SP70585_2152 NC_012468.1 1969319 1969744 R identified by match to protein family HMM PF01022; match to protein family HMM PF01047; transcriptional regulator, MarR family complement(1969319..1969744) Streptococcus pneumoniae 70585 7685184 YP_002741331.1 CDS SP70585_2153 NC_012468.1 1970067 1971179 R identified by match to protein family HMM PF01476; LysM domain-containing protein complement(1970067..1971179) Streptococcus pneumoniae 70585 7684181 YP_002741332.1 CDS SP70585_2156 NC_012468.1 1971982 1973262 R identified by match to protein family HMM PF01554; match to protein family HMM PF03023; match to protein family HMM TIGR00797; multi antimicrobial extrusion complement(1971982..1973262) Streptococcus pneumoniae 70585 7683636 YP_002741333.1 CDS thrC NC_012468.1 1973323 1974807 R catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase complement(1973323..1974807) Streptococcus pneumoniae 70585 7684032 YP_002741334.1 CDS SP70585_2158 NC_012468.1 1974883 1976160 R hypothetical protein complement(1974883..1976160) Streptococcus pneumoniae 70585 7684231 YP_002741335.1 CDS SP70585_2175 NC_012468.1 1982623 1983057 R cytidine/deoxycytidylate deaminase family protein complement(1982623..1983057) Streptococcus pneumoniae 70585 7683896 YP_002741336.1 CDS gltX NC_012468.1 1983071 1984531 R Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase complement(1983071..1984531) Streptococcus pneumoniae 70585 7683173 YP_002741337.1 CDS pgi NC_012468.1 1984655 1986004 R functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase complement(1984655..1986004) Streptococcus pneumoniae 70585 7683695 YP_002741338.1 CDS SP70585_2178 NC_012468.1 1985991 1986170 R hypothetical protein complement(1985991..1986170) Streptococcus pneumoniae 70585 7683537 YP_002741339.1 CDS SP70585_2179 NC_012468.1 1986174 1986863 R identified by match to protein family HMM PF00117; match to protein family HMM PF07722; glutamine amidotransferase complement(1986174..1986863) Streptococcus pneumoniae 70585 7684543 YP_002741340.1 CDS SP70585_2180 NC_012468.1 1987001 1988767 R identified by match to protein family HMM PF00005; match to protein family HMM PF00664; ABC transporter ATP-binding protein/permease complement(1987001..1988767) Streptococcus pneumoniae 70585 7683949 YP_002741341.1 CDS SP70585_2181 NC_012468.1 1988920 1989228 D transposase 1988920..1989228 Streptococcus pneumoniae 70585 7684661 YP_002741342.1 CDS SP70585_2182 NC_012468.1 1989558 1991252 R identified by match to protein family HMM PF00005; match to protein family HMM PF00664; ABC transporter ATP-binding protein/permease complement(1989558..1991252) Streptococcus pneumoniae 70585 7684210 YP_002741343.1 CDS mutS NC_012468.1 1991399 1993933 R This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS complement(1991399..1993933) Streptococcus pneumoniae 70585 7683590 YP_002741344.1 CDS argR NC_012468.1 1993984 1994430 R identified by match to protein family HMM PF01316; match to protein family HMM PF02863; match to protein family HMM TIGR01529; arginine repressor complement(1993984..1994430) Streptococcus pneumoniae 70585 7683493 YP_002741345.1 CDS argS NC_012468.1 1994566 1996257 D catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 1994566..1996257 Streptococcus pneumoniae 70585 7683671 YP_002741346.1 CDS SP70585_2186 NC_012468.1 1996572 1996961 R identified by match to protein family HMM PF01609; transposase (IS4 family) complement(1996572..1996961) Streptococcus pneumoniae 70585 7682932 YP_002741347.1 CDS SP70585_2187 NC_012468.1 1997115 1997600 D identified by match to protein family HMM PF06172; hypothetical protein 1997115..1997600 Streptococcus pneumoniae 70585 7683790 YP_002741348.1 CDS SP70585_2188 NC_012468.1 1997684 1998391 D identified by match to protein family HMM PF00072; match to protein family HMM PF00486; alkaline phosphatase synthesis transcriptional regulatory proteinphoP 1997684..1998391 Streptococcus pneumoniae 70585 7683933 YP_002741349.1 CDS SP70585_2189 NC_012468.1 1998392 1999723 D identified by match to protein family HMM PF00512; match to protein family HMM PF02518; histidine kinase PnpS 1998392..1999723 Streptococcus pneumoniae 70585 7685176 YP_002741350.1 CDS SP70585_2190 NC_012468.1 1999890 2000765 D ABC transporter substrate-binding protein - phosphate transport 1999890..2000765 Streptococcus pneumoniae 70585 7683300 YP_002741351.1 CDS pstC2 NC_012468.1 2000883 2001746 D identified by match to protein family HMM PF00528; match to protein family HMM TIGR02138; phosphate ABC transporter permease 2000883..2001746 Streptococcus pneumoniae 70585 7684591 YP_002741352.1 CDS pstA2 NC_012468.1 2001739 2002554 D identified by match to protein family HMM PF00528; match to protein family HMM TIGR00974; phosphate ABC transporter permease 2001739..2002554 Streptococcus pneumoniae 70585 7683597 YP_002741353.1 CDS pstB3 NC_012468.1 2002556 2003308 D ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein 2002556..2003308 Streptococcus pneumoniae 70585 7683200 YP_002741354.1 CDS phoU2 NC_012468.1 2003323 2003973 D identified by match to protein family HMM PF01895; match to protein family HMM TIGR02135; phosphate transport system regulatory protein PhoU 2003323..2003973 Streptococcus pneumoniae 70585 7685146 YP_002741355.1 CDS SP70585_2195 NC_012468.1 2004041 2004475 D transposase, IS1380-Spn1 related, truncation 2004041..2004475 Streptococcus pneumoniae 70585 7685194 YP_002741356.1 CDS gpsA NC_012468.1 2005215 2006231 D catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 2005215..2006231 Streptococcus pneumoniae 70585 7683383 YP_002741357.1 CDS galU NC_012468.1 2006253 2007152 D identified by match to protein family HMM PF00483; match to protein family HMM TIGR01099; UTP-glucose-1-phosphate uridylyltransferase 2006253..2007152 Streptococcus pneumoniae 70585 7684100 YP_002741358.1 CDS SP70585_2199 NC_012468.1 2007447 2007638 R identified by glimmer; putative; hypothetical protein complement(2007447..2007638) Streptococcus pneumoniae 70585 7684505 YP_002741359.1 CDS SP70585_2200 NC_012468.1 2007652 2008329 R identified by match to protein family HMM PF01694; peptidase, S54 complement(2007652..2008329) Streptococcus pneumoniae 70585 7685071 YP_002741360.1 CDS SP70585_2201 NC_012468.1 2008313 2008852 R identified by match to protein family HMM PF01812; match to protein family HMM TIGR02727; 5-formyltetrahydrofolate cyclo-ligase complement(2008313..2008852) Streptococcus pneumoniae 70585 7683213 YP_002741361.1 CDS SP70585_2202 NC_012468.1 2008864 2009994 R identified by match to protein family HMM PF01546; match to protein family HMM PF07687; match to protein family HMM TIGR01891; peptidase, M20/M25/M40 family complement(2008864..2009994) Streptococcus pneumoniae 70585 7683782 YP_002741362.1 CDS SP70585_2203 NC_012468.1 2010062 2010760 R identified by match to protein family HMM PF00132; match to protein family HMM PF08503; galactoside O-acetyltransferase complement(2010062..2010760) Streptococcus pneumoniae 70585 7684615 YP_002741363.1 CDS SP70585_2204 NC_012468.1 2010990 2011901 R identified by match to protein family HMM PF00892; membrane protein complement(2010990..2011901) Streptococcus pneumoniae 70585 7683847 YP_002741364.1 CDS SP70585_2205 NC_012468.1 2011966 2014428 R identified by match to protein family HMM PF00905; match to protein family HMM PF00912; penicillin-binding protein 1B complement(2011966..2014428) Streptococcus pneumoniae 70585 7683434 YP_002741365.1 CDS tyrS NC_012468.1 2014570 2015826 D catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 2014570..2015826 Streptococcus pneumoniae 70585 7684452 YP_002741366.1 CDS SP70585_2207 NC_012468.1 2015904 2017967 R identified by match to protein family HMM PF00122; match to protein family HMM PF00702; match to protein family HMM TIGR01494; match to protein family HMM TIGR01525; P-type ATPase-metal/cation transport complement(2015904..2017967) Streptococcus pneumoniae 70585 7683364 YP_002741367.1 CDS SP70585_2208 NC_012468.1 2017969 2018247 R hypothetical protein complement(2017969..2018247) Streptococcus pneumoniae 70585 7684828 YP_002741368.1 CDS SP70585_2209 NC_012468.1 2018399 2019247 D identified by match to protein family HMM PF08241; 23S rRNA m1G745 methyltransferase 2018399..2019247 Streptococcus pneumoniae 70585 7683546 YP_002741369.1 CDS SP70585_2210 NC_012468.1 2020070 2020642 D hypothetical protein 2020070..2020642 Streptococcus pneumoniae 70585 7683241 YP_002741370.1 CDS SP70585_2211 NC_012468.1 2021687 2023945 R identified by match to protein family HMM PF00343; match to protein family HMM TIGR02093; glycogen phosphorylase complement(2021687..2023945) Streptococcus pneumoniae 70585 7682909 YP_002741371.1 CDS malQ NC_012468.1 2023971 2025488 R amylomaltase; acts to release glucose from maltodextrins; 4-alpha-glucanotransferase complement(2023971..2025488) Streptococcus pneumoniae 70585 7684684 YP_002741372.1 CDS SP70585_2213 NC_012468.1 2026038 2027309 D identified by match to protein family HMM PF01547; maltose/maltodextrin-binding protein 2026038..2027309 Streptococcus pneumoniae 70585 7683948 YP_002741373.1 CDS SP70585_2214 NC_012468.1 2027420 2028712 D identified by match to protein family HMM PF00528; match to protein family HMM PF05154; maltodextrin transport system permease MalC 2027420..2028712 Streptococcus pneumoniae 70585 7684674 YP_002741374.1 CDS SP70585_2215 NC_012468.1 2028714 2029556 D identified by match to protein family HMM PF00528; maltose/maltodextrin ABC transporter permease 2028714..2029556 Streptococcus pneumoniae 70585 7682921 YP_002741375.1 CDS SP70585_2216 NC_012468.1 2029809 2030609 D maltodextrose utilization protein MalA 2029809..2030609 Streptococcus pneumoniae 70585 7684406 YP_002741376.1 CDS SP70585_2217 NC_012468.1 2030619 2031605 D identified by match to protein family HMM PF00356; match to protein family HMM PF00532; HTH-type transcriptional regulator MalR (Maltose operontranscriptional repressor) 2030619..2031605 Streptococcus pneumoniae 70585 7683481 YP_002741377.1 CDS SP70585_2218 NC_012468.1 2031672 2031995 D identified by glimmer; putative; hypothetical protein 2031672..2031995 Streptococcus pneumoniae 70585 7683840 YP_002741378.1 CDS SP70585_2219 NC_012468.1 2032031 2032972 R identified by match to protein family HMM PF02588; YitT family protein complement(2032031..2032972) Streptococcus pneumoniae 70585 7683221 YP_002741379.1 CDS aspS NC_012468.1 2032950 2034713 R catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase complement(2032950..2034713) Streptococcus pneumoniae 70585 7683793 YP_002741380.1 CDS SP70585_2221 NC_012468.1 2034832 2035005 R chlorohydrolase complement(2034832..2035005) Streptococcus pneumoniae 70585 7685040 YP_002741381.1 CDS SP70585_2222 NC_012468.1 2035110 2035340 R hypothetical protein complement(2035110..2035340) Streptococcus pneumoniae 70585 7683972 YP_002741382.1 CDS SP70585_2223 NC_012468.1 2035358 2035999 R identified by match to protein family HMM PF02517; caax amino protease family complement(2035358..2035999) Streptococcus pneumoniae 70585 7685024 YP_002741383.1 CDS SP70585_2224 NC_012468.1 2036011 2036745 R hypothetical protein complement(2036011..2036745) Streptococcus pneumoniae 70585 7684669 YP_002741384.1 CDS SP70585_2225 NC_012468.1 2036748 2036945 R hypothetical protein complement(2036748..2036945) Streptococcus pneumoniae 70585 7683100 YP_002741385.1 CDS SP70585_2226 NC_012468.1 2036945 2037151 R identified by match to protein family HMM PF01381; hypothetical protein complement(2036945..2037151) Streptococcus pneumoniae 70585 7684328 YP_002741386.1 CDS SP70585_2227 NC_012468.1 2037161 2037475 R hypothetical protein complement(2037161..2037475) Streptococcus pneumoniae 70585 7684056 YP_002741387.1 CDS SP70585_2228 NC_012468.1 2037429 2037581 R identified by glimmer; putative; hypothetical protein complement(2037429..2037581) Streptococcus pneumoniae 70585 7684862 YP_002741388.1 CDS SP70585_2229 NC_012468.1 2037625 2037753 R chlorohydrolase complement(2037625..2037753) Streptococcus pneumoniae 70585 7684491 YP_002741389.1 CDS hisS NC_012468.1 2037813 2039102 R catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase complement(2037813..2039102) Streptococcus pneumoniae 70585 7684128 YP_002741390.1 CDS SP70585_2233 NC_012468.1 2041327 2043051 R identified by match to protein family HMM PF00933; beta-N-acetylglucosaminidase/beta-glucosidase (3-beta-N-acetyl-D-glucosaminidase/beta-D- glucosidase)(Nag3) complement(2041327..2043051) Streptococcus pneumoniae 70585 7685120 YP_002741391.1 CDS SP70585_2234 NC_012468.1 2043062 2044852 R identified by match to protein family HMM PF00933; beta-N-acetylglucosaminidase/beta-glucosidase (3-beta-N-acetyl-D-glucosaminidase/beta-D- glucosidase)(Nag3) complement(2043062..2044852) Streptococcus pneumoniae 70585 7683881 YP_002741392.1 CDS SP70585_2235 NC_012468.1 2044899 2045696 R phosphoglycolate phosphatase complement(2044899..2045696) Streptococcus pneumoniae 70585 7684066 YP_002741393.1 CDS SP70585_2236 NC_012468.1 2045699 2046538 R Converts D-mannonate to D-mannuronate; D-mannonate oxidoreductase complement(2045699..2046538) Streptococcus pneumoniae 70585 7684458 YP_002741394.1 CDS uxuA NC_012468.1 2046541 2047641 R catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate; mannonate dehydratase complement(2046541..2047641) Streptococcus pneumoniae 70585 7683489 YP_002741395.1 CDS uxaC NC_012468.1 2047655 2049055 R catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism; glucuronate isomerase complement(2047655..2049055) Streptococcus pneumoniae 70585 7683940 YP_002741396.1 CDS SP70585_2239 NC_012468.1 2049057 2049677 R identified by match to protein family HMM PF01081; match to protein family HMM TIGR01182; khg/kdpg aldolase complement(2049057..2049677) Streptococcus pneumoniae 70585 7685149 YP_002741397.1 CDS SP70585_2240 NC_012468.1 2049800 2050516 R identified by match to protein family HMM PF00392; match to protein family HMM PF07729; GntR family transcriptional regulator complement(2049800..2050516) Streptococcus pneumoniae 70585 7684487 YP_002741398.1 CDS SP70585_2241 NC_012468.1 2050562 2052361 R identified by match to protein family HMM PF00703; match to protein family HMM PF02836; match to protein family HMM PF02837; beta-D-glucuronidase complement(2050562..2052361) Streptococcus pneumoniae 70585 7683375 YP_002741399.1 CDS SP70585_2242 NC_012468.1 2052376 2053404 R identified by match to protein family HMM PF00294; sugar kinase, ribokinase family complement(2052376..2053404) Streptococcus pneumoniae 70585 7684180 YP_002741400.1 CDS SP70585_2243 NC_012468.1 2053480 2055033 R sugar/sodium symporter complement(2053480..2055033) Streptococcus pneumoniae 70585 7684891 YP_002741401.1 CDS SP70585_2244 NC_012468.1 2055220 2055537 R identified by glimmer; putative; hypothetical protein complement(2055220..2055537) Streptococcus pneumoniae 70585 7683453 YP_002741402.1 CDS SP70585_2245 NC_012468.1 2055598 2056155 R identified by glimmer; putative; hypothetical protein complement(2055598..2056155) Streptococcus pneumoniae 70585 7683215 YP_002741403.1 CDS SP70585_2246 NC_012468.1 2056185 2056376 R hypothetical protein complement(2056185..2056376) Streptococcus pneumoniae 70585 7682898 YP_002741404.1 CDS SP70585_2247 NC_012468.1 2056419 2057648 R hypothetical protein complement(2056419..2057648) Streptococcus pneumoniae 70585 7683628 YP_002741405.1 CDS SP70585_2248 NC_012468.1 2057839 2058600 R identified by match to protein family HMM TIGR01716; positive transcriptional regulator of glucosyltransferase and Spp phenotype complement(2057839..2058600) Streptococcus pneumoniae 70585 7684435 YP_002741406.1 CDS SP70585_2249 NC_012468.1 2058665 2058799 R hypothetical protein complement(2058665..2058799) Streptococcus pneumoniae 70585 7683730 YP_002741407.1 CDS SP70585_2250 NC_012468.1 2058814 2059155 D identified by match to protein family HMM PF01883; hypothetical protein 2058814..2059155 Streptococcus pneumoniae 70585 7682900 YP_002741408.1 CDS SP70585_2251 NC_012468.1 2059219 2059428 D chlorohydrolase 2059219..2059428 Streptococcus pneumoniae 70585 7683082 YP_002741409.1 CDS ilvD NC_012468.1 2059454 2061157 R catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase complement(2059454..2061157) Streptococcus pneumoniae 70585 7683192 YP_002741410.1 CDS SP70585_2253 NC_012468.1 2061390 2062322 R identified by match to protein family HMM PF02779; match to protein family HMM PF02780; transketolase, C- subunit complement(2061390..2062322) Streptococcus pneumoniae 70585 7685102 YP_002741411.1 CDS SP70585_2254 NC_012468.1 2062319 2063176 R identified by match to protein family HMM PF00456; transketolase, thiamine disphosphate-binding subunit complement(2062319..2063176) Streptococcus pneumoniae 70585 7683712 YP_002741412.1 CDS ulaA NC_012468.1 2063180 2064526 R membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC complement(2063180..2064526) Streptococcus pneumoniae 70585 7683134 YP_002741413.1 CDS SP70585_2256 NC_012468.1 2064539 2064823 R identified by match to protein family HMM PF02302; phosphotransferase system, galactitol-specific IIB component complement(2064539..2064823) Streptococcus pneumoniae 70585 7683012 YP_002741414.1 CDS SP70585_2257 NC_012468.1 2064827 2066857 R identified by match to protein family HMM PF00359; match to protein family HMM PF00874; transcriptional regulator, BglG family protein complement(2064827..2066857) Streptococcus pneumoniae 70585 7683812 YP_002741415.1 CDS SP70585_2258 NC_012468.1 2067049 2068056 D identified by match to protein family HMM PF01145; integral membrane protein 2067049..2068056 Streptococcus pneumoniae 70585 7683796 YP_002741416.1 CDS SP70585_2259 NC_012468.1 2068059 2068259 D hypothetical protein 2068059..2068259 Streptococcus pneumoniae 70585 7684174 YP_002741417.1 CDS rpmF NC_012468.1 2068411 2068593 D some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 2068411..2068593 Streptococcus pneumoniae 70585 7685003 YP_002741418.1 CDS rpmG NC_012468.1 2068609 2068758 D in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 2068609..2068758 Streptococcus pneumoniae 70585 7683741 YP_002741419.1 CDS SP70585_2262 NC_012468.1 2069238 2071163 R identified by match to protein family HMM PF01473; choline binding protein PcpA complement(2069238..2071163) Streptococcus pneumoniae 70585 7684619 YP_002741420.1 CDS SP70585_2263 NC_012468.1 2071498 2071680 D an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by glimmer; putative; hypothetical protein 2071498..2071680 Streptococcus pneumoniae 70585 7685092 YP_002741421.1 CDS SP70585_2265 NC_012468.1 2072041 2072187 D an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; transposase B 2072041..2072187 Streptococcus pneumoniae 70585 7683675 YP_002741422.1 CDS SP70585_2266 NC_012468.1 2072194 2072430 D an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; mobile genetic element 2072194..2072430 Streptococcus pneumoniae 70585 7685111 YP_002741423.1 CDS SP70585_2267 NC_012468.1 2072514 2072654 R identified by glimmer; putative; hypothetical protein complement(2072514..2072654) Streptococcus pneumoniae 70585 7683284 YP_002741424.1 CDS SP70585_2268 NC_012468.1 2072669 2072800 R identified by glimmer; putative; hypothetical protein complement(2072669..2072800) Streptococcus pneumoniae 70585 7684573 YP_002741425.1 CDS SP70585_2269 NC_012468.1 2073067 2074947 R identified by match to protein family HMM PF00728; N-acetyl-beta-D-glucosaminidase complement(2073067..2074947) Streptococcus pneumoniae 70585 7683347 YP_002741426.1 CDS SP70585_2270 NC_012468.1 2074941 2075810 R identified by match to protein family HMM PF00480; ROK family protein complement(2074941..2075810) Streptococcus pneumoniae 70585 7684095 YP_002741427.1 CDS SP70585_2271 NC_012468.1 2075894 2078539 R identified by match to protein family HMM PF01074; match to protein family HMM PF07748; glycosyl hydrolase, family 38 complement(2075894..2078539) Streptococcus pneumoniae 70585 7683350 YP_002741428.1 CDS SP70585_2272 NC_012468.1 2078630 2079910 R identified by match to protein family HMM PF06824; hypothetical protein complement(2078630..2079910) Streptococcus pneumoniae 70585 7684091 YP_002741429.1 CDS SP70585_2273 NC_012468.1 2080081 2082165 D identified by match to protein family HMM PF07971; match to protein family HMM TIGR01180; antigen, cell wall surface anchor family 2080081..2082165 Streptococcus pneumoniae 70585 7685020 YP_002741430.1 CDS SP70585_2274 NC_012468.1 2082205 2083884 R identified by match to protein family HMM PF00754; putative alpha-L-fucosidase 1 (Alpha-L-fucoside fucohydrolase) complement(2082205..2083884) Streptococcus pneumoniae 70585 7684845 YP_002741431.1 CDS arcA NC_012468.1 2084639 2085868 D catalyzes the degradation of arginine to citruline and ammonia; arginine deiminase 2084639..2085868 Streptococcus pneumoniae 70585 7685155 YP_002741432.1 CDS argF NC_012468.1 2085926 2086942 D catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway; ornithine carbamoyltransferase 2085926..2086942 Streptococcus pneumoniae 70585 7684425 YP_002741433.1 CDS arcC NC_012468.1 2087107 2088054 D catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase 2087107..2088054 Streptococcus pneumoniae 70585 7684735 YP_002741434.1 CDS SP70585_2278 NC_012468.1 2088265 2089776 D identified by match to protein family HMM PF03606; arginine-ornithine antiporter 2088265..2089776 Streptococcus pneumoniae 70585 7683299 YP_002741435.1 CDS SP70585_2279 NC_012468.1 2089798 2091129 D identified by match to protein family HMM PF01546; match to protein family HMM TIGR01887; hypothetical protein 2089798..2091129 Streptococcus pneumoniae 70585 7683480 YP_002741436.1 CDS SP70585_2280 NC_012468.1 2091811 2092077 R identified by match to protein family HMM PF04650; match to protein family HMM TIGR01168; gram-positive signal peptide, ysirk family protein complement(2091811..2092077) Streptococcus pneumoniae 70585 7683731 YP_002741437.1 CDS SP70585_2281 NC_012468.1 2092266 2092469 D identified by glimmer; putative; hypothetical protein 2092266..2092469 Streptococcus pneumoniae 70585 7683142 YP_002741438.1 CDS SP70585_2282 NC_012468.1 2092506 2093405 R identified by match to protein family HMM PF01145; spfh domain/band 7 family complement(2092506..2093405) Streptococcus pneumoniae 70585 7684832 YP_002741439.1 CDS SP70585_2283 NC_012468.1 2093535 2094686 R identified by match to protein family HMM PF00465; NAD-dependent methanol dehydrogenase (medh) complement(2093535..2094686) Streptococcus pneumoniae 70585 7684707 YP_002741440.1 CDS fucI NC_012468.1 2094832 2096598 R catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose; L-fucose isomerase complement(2094832..2096598) Streptococcus pneumoniae 70585 7683059 YP_002741441.1 CDS SP70585_2285 NC_012468.1 2096611 2097339 R identified by match to protein family HMM PF00596; L-fuculose phosphate aldolase complement(2096611..2097339) Streptococcus pneumoniae 70585 7685035 YP_002741442.1 CDS SP70585_2286 NC_012468.1 2097354 2100371 R identified by match to protein family HMM PF08305; blood group A- and B-cleaving endo-beta-galactosidase complement(2097354..2100371) Streptococcus pneumoniae 70585 7684726 YP_002741443.1 CDS SP70585_2287 NC_012468.1 2100382 2102598 R identified by match to protein family HMM PF02065; alpha-galactosidase AgaN complement(2100382..2102598) Streptococcus pneumoniae 70585 7683738 YP_002741444.1 CDS SP70585_2288 NC_012468.1 2102620 2104491 R F5/8 type C domain containing protein complement(2102620..2104491) Streptococcus pneumoniae 70585 7683437 YP_002741445.1 CDS SP70585_2289 NC_012468.1 2104497 2105816 R identified by match to protein family HMM PF01120; alpha-L-fucosidase complement(2104497..2105816) Streptococcus pneumoniae 70585 7684025 YP_002741446.1 CDS SP70585_2290 NC_012468.1 2105813 2106652 R identified by match to protein family HMM PF00528; sugar ABC transporter permease complement(2105813..2106652) Streptococcus pneumoniae 70585 7684207 YP_002741447.1 CDS SP70585_2291 NC_012468.1 2106655 2107584 R identified by match to protein family HMM PF00528; sugar ABC transporter permease complement(2106655..2107584) Streptococcus pneumoniae 70585 7685095 YP_002741448.1 CDS SP70585_2292 NC_012468.1 2107672 2108964 R identified by match to protein family HMM PF01547; extracellular solute-binding protein complement(2107672..2108964) Streptococcus pneumoniae 70585 7684192 YP_002741449.1 CDS SP70585_2293 NC_012468.1 2108994 2110397 R identified by match to protein family HMM PF00370; rhamnulokinase (Rhamnulose kinase) complement(2108994..2110397) Streptococcus pneumoniae 70585 7684448 YP_002741450.1 CDS SP70585_2294 NC_012468.1 2110573 2111346 D identified by match to protein family HMM PF00455; match to protein family HMM PF08220; match to protein family HMM PF08279; regulator of fucose operon 2110573..2111346 Streptococcus pneumoniae 70585 7683615 YP_002741451.1 CDS SP70585_2295 NC_012468.1 2112474 2113979 R identified by match to protein family HMM PF01297; match to protein family HMM PF09223; zinc-binding lipoprotein AdcA complement(2112474..2113979) Streptococcus pneumoniae 70585 7682929 YP_002741452.1 CDS SP70585_2296 NC_012468.1 2113989 2114795 R identified by match to protein family HMM PF00950; zinc ABC transporter permease complement(2113989..2114795) Streptococcus pneumoniae 70585 7683283 YP_002741453.1 CDS SP70585_2297 NC_012468.1 2114788 2115492 R identified by match to protein family HMM PF00005; zinc transport system ATP-binding protein AdcC complement(2114788..2115492) Streptococcus pneumoniae 70585 7683122 YP_002741454.1 CDS SP70585_2298 NC_012468.1 2115492 2115932 R identified by match to protein family HMM PF01022; match to protein family HMM PF01047; match to protein family HMM PF01325; match to protein family HMM PF01978; match to protein family HMM PF08279; putative transcriptional repressor complement(2115492..2115932) Streptococcus pneumoniae 70585 7684120 YP_002741455.1 CDS SP70585_2299 NC_012468.1 2115917 2116054 D hypothetical protein 2115917..2116054 Streptococcus pneumoniae 70585 7684544 YP_002741456.1 CDS SP70585_2300 NC_012468.1 2116087 2117355 R identified by match to protein family HMM PF04914; match to protein family HMM PF04915; match to protein family HMM PF04918; D-alanine transfer from undecaprenol-phosphate to the poly complement(2116087..2117355) Streptococcus pneumoniae 70585 7684613 YP_002741457.1 CDS dltC NC_012468.1 2117348 2117587 R D-alanyl carrier protein subunit; involved in the incorporation of D-alanine into membrane-associated D-alanyl-lipoteichoic acid; D-alanyl carrier protein is the acceptor of activated D-alanine which it donates to a membrane acceptor(D-alanyl transferase) for incorporation into membrane lipoteichoic acid; D-alanine--poly(phosphoribitol) ligase subunit 2 complement(2117348..2117587) Streptococcus pneumoniae 70585 7683549 YP_002741458.1 CDS dltA NC_012468.1 2118842 2120392 R transfers D-alanine to the D-alanyl carrier protein during the incorporation of D-alanine into lipoteichoic acid; D-alanine--poly(phosphoribitol) ligase subunit 1 complement(2118842..2120392) Streptococcus pneumoniae 70585 7684868 YP_002741459.1 CDS SP70585_2305 NC_012468.1 2120413 2120544 R hypothetical protein complement(2120413..2120544) Streptococcus pneumoniae 70585 7684634 YP_002741460.1 CDS SP70585_2306 NC_012468.1 2120868 2121773 R permease of the major facilitator superfamily complement(2120868..2121773) Streptococcus pneumoniae 70585 7683734 YP_002741461.1 CDS SP70585_2307 NC_012468.1 2122502 2123779 R identified by match to protein family HMM PF00078; match to protein family HMM PF08388; GBSi1, group II intron, maturase complement(2122502..2123779) Streptococcus pneumoniae 70585 7684295 YP_002741462.1 CDS SP70585_2308 NC_012468.1 2124818 2125477 D hypothetical protein 2124818..2125477 Streptococcus pneumoniae 70585 7683112 YP_002741463.1 CDS SP70585_2309 NC_012468.1 2125564 2125767 R identified by glimmer; putative; hypothetical protein complement(2125564..2125767) Streptococcus pneumoniae 70585 7684724 YP_002741464.1 CDS SP70585_2310 NC_012468.1 2126064 2126768 R identified by match to protein family HMM PF00230; match to protein family HMM TIGR00861; glycerol uptake facilitator protein complement(2126064..2126768) Streptococcus pneumoniae 70585 7685080 YP_002741465.1 CDS SP70585_2311 NC_012468.1 2126838 2128664 R identified by match to protein family HMM PF01266; alpha-glycerophosphate oxidase (Glycerol-3-phosphateoxidase) (Exported protein 6) complement(2126838..2128664) Streptococcus pneumoniae 70585 7683795 YP_002741466.1 CDS glpK NC_012468.1 2128706 2130214 R Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase complement(2128706..2130214) Streptococcus pneumoniae 70585 7685057 YP_002741467.1 CDS SP70585_2313 NC_012468.1 2130373 2131782 R identified by match to protein family HMM PF05043; M protein trans-acting positive regulator (MGA) complement(2130373..2131782) Streptococcus pneumoniae 70585 7683385 YP_002741468.1 CDS hslO NC_012468.1 2131965 2132837 D becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; Hsp33-like chaperonin 2131965..2132837 Streptococcus pneumoniae 70585 7683772 YP_002741469.1 CDS SP70585_2315 NC_012468.1 2132824 2133804 D identified by match to protein family HMM PF00724; match to protein family HMM PF01180; match to protein family HMM PF01207; match to protein family HMM TIGR00737; tRNA-dihydrouridine synthase B 2132824..2133804 Streptococcus pneumoniae 70585 7684977 YP_002741470.1 CDS SP70585_2316 NC_012468.1 2134034 2136112 R identified by match to protein family HMM PF01473; match to protein family HMM PF04650; match to protein family HMM PF05062; match to protein family HMM TIGR01168; choline binding protein A complement(2134034..2136112) Streptococcus pneumoniae 70585 7683177 YP_002741471.1 CDS SP70585_2317 NC_012468.1 2136191 2136718 R identified by match to protein family HMM PF04140; hypothetical protein complement(2136191..2136718) Streptococcus pneumoniae 70585 7685013 YP_002741472.1 CDS SP70585_2318 NC_012468.1 2136801 2138132 R identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; histidine kinase complement(2136801..2138132) Streptococcus pneumoniae 70585 7683834 YP_002741473.1 CDS SP70585_2319 NC_012468.1 2138129 2138782 R identified by match to protein family HMM PF00072; match to protein family HMM PF00486; response regulator complement(2138129..2138782) Streptococcus pneumoniae 70585 7683389 YP_002741474.1 CDS SP70585_2320 NC_012468.1 2139071 2139205 R hypothetical protein complement(2139071..2139205) Streptococcus pneumoniae 70585 7685064 YP_002741475.1 CDS SP70585_2321 NC_012468.1 2139222 2139353 D DNA alkylation repair enzyme 2139222..2139353 Streptococcus pneumoniae 70585 7683526 YP_002741476.1 CDS clpB NC_012468.1 2139424 2141856 R identified by match to protein family HMM PF00004; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM PF07728; ClpB protein complement(2139424..2141856) Streptococcus pneumoniae 70585 7684479 YP_002741477.1 CDS SP70585_2323 NC_012468.1 2141858 2142316 R identified by match to protein family HMM PF05848; transcriptional regulator CtsR complement(2141858..2142316) Streptococcus pneumoniae 70585 7684014 YP_002741478.1 CDS SP70585_2324 NC_012468.1 2142435 2143163 R identified by match to protein family HMM PF00005; anion ABC transporter ATP-binding protein complement(2142435..2143163) Streptococcus pneumoniae 70585 7685167 YP_002741479.1 CDS SP70585_2325 NC_012468.1 2143163 2144170 R identified by match to protein family HMM PF09084; ABC transporter substrate-binding protein complement(2143163..2144170) Streptococcus pneumoniae 70585 7683960 YP_002741480.1 CDS SP70585_2326 NC_012468.1 2144208 2144969 R identified by match to protein family HMM PF00528; ABC transporter permease complement(2144208..2144969) Streptococcus pneumoniae 70585 7684143 YP_002741481.1 CDS SP70585_2327 NC_012468.1 2144929 2145219 R hypothetical protein complement(2144929..2145219) Streptococcus pneumoniae 70585 7684871 YP_002741482.1 CDS SP70585_2328 NC_012468.1 2145475 2146593 R identified by match to protein family HMM PF01473; match to protein family HMM PF05257; match to protein family HMM PF08460; choline binding protein D complement(2145475..2146593) Streptococcus pneumoniae 70585 7684715 YP_002741483.1 CDS SP70585_2329 NC_012468.1 2146682 2146948 R identified by match to protein family HMM PF06257; hypothetical protein complement(2146682..2146948) Streptococcus pneumoniae 70585 7684252 YP_002741484.1 CDS dnaB NC_012468.1 2146950 2148302 R unwinds double stranded DNA; replicative DNA helicase complement(2146950..2148302) Streptococcus pneumoniae 70585 7684467 YP_002741485.1 CDS rplI NC_012468.1 2148345 2148797 R in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 complement(2148345..2148797) Streptococcus pneumoniae 70585 7684624 YP_002741486.1 CDS SP70585_2332 NC_012468.1 2148794 2150767 R identified by match to protein family HMM PF01368; match to protein family HMM PF02272; DHH subfamily 1 protein complement(2148794..2150767) Streptococcus pneumoniae 70585 7683996 YP_002741487.1 CDS SP70585_2333 NC_012468.1 2150903 2151451 R identified by match to protein family HMM PF02482; match to protein family HMM TIGR00741; ribosome-associated protein Y complement(2150903..2151451) Streptococcus pneumoniae 70585 7683520 YP_002741488.1 CDS SP70585_2334 NC_012468.1 2151530 2152192 R transformation-related protein complement(2151530..2152192) Streptococcus pneumoniae 70585 7684169 YP_002741489.1 CDS SP70585_2335 NC_012468.1 2152189 2153487 R identified by match to protein family HMM PF00271; match to protein family HMM PF04851; superfamily II ATP-dependent DNA/RNA helicase required for DNA uptake complement(2152189..2153487) Streptococcus pneumoniae 70585 7683042 YP_002741490.1 CDS SP70585_2336 NC_012468.1 2153543 2154178 D identified by match to protein family HMM PF01205; match to protein family HMM PF09186; match to protein family HMM TIGR00257; hypothetical protein 2153543..2154178 Streptococcus pneumoniae 70585 7683492 YP_002741491.1 CDS cysK NC_012468.1 2154463 2155383 D identified by match to protein family HMM PF00291; match to protein family HMM TIGR01136; match to protein family HMM TIGR01139; cysteine synthase A 2154463..2155383 Streptococcus pneumoniae 70585 7684350 YP_002741492.1 CDS SP70585_2338 NC_012468.1 2155580 2155978 R an automated process has identified a potential problem with this gene model; the current end5 and/or the end3 may need to extended or the current gene model may need to be merged with a neighboring gene model; the current gene model (or a revised gene model) may contain a frame shift; identified by match to protein family HMM PF03050; transposase complement(2155580..2155978) Streptococcus pneumoniae 70585 7684249 YP_002741493.1 CDS SP70585_2339 NC_012468.1 2156011 2156277 D transposase family protein 2156011..2156277 Streptococcus pneumoniae 70585 7685090 YP_002741494.1 CDS SP70585_2340 NC_012468.1 2156450 2156737 R identified by match to protein family HMM PF05717; transposase complement(2156450..2156737) Streptococcus pneumoniae 70585 7684705 YP_002741495.1 CDS tsf NC_012468.1 2156983 2158023 R EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts complement(2156983..2158023) Streptococcus pneumoniae 70585 7684260 YP_002741496.1 CDS rpsB NC_012468.1 2158102 2158881 R one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 complement(2158102..2158881) Streptococcus pneumoniae 70585 7683518 YP_002741497.1 CDS SP70585_2343 NC_012468.1 2159105 2160283 R identified by match to protein family HMM PF05257; general stress protein GSP-781 complement(2159105..2160283) Streptococcus pneumoniae 70585 7683993 YP_002741498.1 CDS mreD NC_012468.1 2160377 2160871 R identified by match to protein family HMM PF04093; match to protein family HMM TIGR03426; rod shape-determining protein MreD complement(2160377..2160871) Streptococcus pneumoniae 70585 7684148 YP_002741499.1 CDS mreC NC_012468.1 2160871 2161689 R in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall; rod shape-determining protein MreC complement(2160871..2161689) Streptococcus pneumoniae 70585 7683865 YP_002741500.1 CDS SP70585_2346 NC_012468.1 2161748 2162542 R identified by match to protein family HMM PF02361; ABC transporter permease complement(2161748..2162542) Streptococcus pneumoniae 70585 7683951 YP_002741501.1 CDS cbiO NC_012468.1 2162535 2163374 R with CbiNQ forms the ABC transporter for cobalt import; Streptococcus has two adjacent copies of this gene; cobalt transporter ATP-binding subunit complement(2162535..2163374) Streptococcus pneumoniae 70585 7684501 YP_002741502.1 CDS cbiO NC_012468.1 2163359 2164186 R with CbiNQ forms the ABC transporter for cobalt import; Streptococcus has two adjacent copies of this gene; cobalt transporter ATP-binding subunit complement(2163359..2164186) Streptococcus pneumoniae 70585 7684079 YP_002741503.1 CDS pgsA NC_012468.1 2164183 2164728 R identified by match to protein family HMM PF01066; match to protein family HMM TIGR00560; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase complement(2164183..2164728) Streptococcus pneumoniae 70585 7684905 YP_002741504.1 CDS SP70585_2350 NC_012468.1 2164739 2165560 R hypothetical protein complement(2164739..2165560) Streptococcus pneumoniae 70585 7683223 YP_002741505.1 CDS SP70585_2351 NC_012468.1 2165602 2166885 R identified by match to protein family HMM PF00675; match to protein family HMM PF05193; peptidase, M16 family complement(2165602..2166885) Streptococcus pneumoniae 70585 7683423 YP_002741506.1 CDS SP70585_2352 NC_012468.1 2166882 2168132 R identified by match to protein family HMM PF05193; peptidase, M16 family complement(2166882..2168132) Streptococcus pneumoniae 70585 7682890 YP_002741507.1 CDS SP70585_2353 NC_012468.1 2168291 2168659 D identified by match to protein family HMM TIGR02988; S4 domain protein YaaA, putative 2168291..2168659 Streptococcus pneumoniae 70585 7685049 YP_002741508.1 CDS recF NC_012468.1 2168662 2169759 D Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 2168662..2169759 Streptococcus pneumoniae 70585 7683798 YP_002741509.1 CDS guaB NC_012468.1 2169810 2171288 R catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase complement(2169810..2171288) Streptococcus pneumoniae 70585 7683038 YP_002741510.1 CDS trpS NC_012468.1 2171440 2172465 R catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase II complement(2171440..2172465) Streptococcus pneumoniae 70585 7684080 YP_002741511.1 CDS SP70585_2357 NC_012468.1 2172671 2174293 D identified by match to protein family HMM PF00005; ATPase component of ABC transporters with duplicated ATPase domains 2172671..2174293 Streptococcus pneumoniae 70585 7683879 YP_002741512.1 CDS SP70585_2358 NC_012468.1 2174355 2176907 D ABC transporter permease 2174355..2176907 Streptococcus pneumoniae 70585 7683987 YP_002741513.1 CDS SP70585_2359 NC_012468.1 2177350 2177688 R identified by glimmer; putative; hypothetical protein complement(2177350..2177688) Streptococcus pneumoniae 70585 7684215 YP_002741514.1 CDS SP70585_2360 NC_012468.1 2177773 2178540 R identified by glimmer; putative; hypothetical protein complement(2177773..2178540) Streptococcus pneumoniae 70585 7685096 YP_002741515.1 CDS SP70585_2361 NC_012468.1 2178719 2179261 D identified by match to protein family HMM PF00440; TetR family transcriptional regulator 2178719..2179261 Streptococcus pneumoniae 70585 7684258 YP_002741516.1 CDS SP70585_2364 NC_012468.1 2179504 2180256 R identified by match to protein family HMM PF00072; match to protein family HMM PF04397; response regulator complement(2179504..2180256) Streptococcus pneumoniae 70585 7683927 YP_002741517.1 CDS SP70585_2365 NC_012468.1 2180253 2181578 R identified by match to protein family HMM PF02518; ComD complement(2180253..2181578) Streptococcus pneumoniae 70585 7684204 YP_002741518.1 CDS SP70585_2366 NC_012468.1 2181599 2181724 R identified by match to protein family HMM PF03047; hypothetical protein complement(2181599..2181724) Streptococcus pneumoniae 70585 7683726 YP_002741519.1 CDS SP70585_2368 NC_012468.1 2182007 2182486 R SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase complement(2182007..2182486) Streptococcus pneumoniae 70585 7684310 YP_002741520.1 CDS SP70585_2369 NC_012468.1 2182669 2183850 D identified by match to protein family HMM PF00089; trypsin domain protein 2182669..2183850 Streptococcus pneumoniae 70585 7683757 YP_002741521.1 CDS SP70585_2370 NC_012468.1 2183908 2184666 D identified by match to protein family HMM PF02195; match to protein family HMM TIGR00180; stage 0 sporulation protein J 2183908..2184666 Streptococcus pneumoniae 70585 7684342 SP70585_0016 tRNA SP70585_0016 NC_012468.1 16445 16519 D tRNA-Glu 16445..16519 Streptococcus pneumoniae 70585 7684063 SP70585_0018 tRNA SP70585_0018 NC_012468.1 18365 18442 D tRNA-Ala 18365..18442 Streptococcus pneumoniae 70585 7684290 SP70585_0022 tRNA SP70585_0022 NC_012468.1 21662 21738 D tRNA-Asn 21662..21738 Streptococcus pneumoniae 70585 7684289 SP70585_0897 tRNA SP70585_0897 NC_012468.1 820767 820850 D tRNA-Tyr 820767..820850 Streptococcus pneumoniae 70585 7683287 SP70585_0898 tRNA SP70585_0898 NC_012468.1 820857 820931 D tRNA-Gln 820857..820931 Streptococcus pneumoniae 70585 7683928 SP70585_0912 tRNA SP70585_0912 NC_012468.1 835312 835404 R tRNA-Ser complement(835312..835404) Streptococcus pneumoniae 70585 7683929 SP70585_1052 tRNA SP70585_1052 NC_012468.1 969423 969498 D tRNA-Thr 969423..969498 Streptococcus pneumoniae 70585 7683984 SP70585_1311 tRNA SP70585_1311 NC_012468.1 1218467 1218543 R tRNA-Arg complement(1218467..1218543) Streptococcus pneumoniae 70585 7685177 SP70585_1357 tRNA SP70585_1357 NC_012468.1 1261665 1261739 R tRNA-Arg complement(1261665..1261739) Streptococcus pneumoniae 70585 7683027 SP70585_1622 tRNA SP70585_1622 NC_012468.1 1501164 1501254 R tRNA-Leu complement(1501164..1501254) Streptococcus pneumoniae 70585 7682975 SP70585_1837 tRNA SP70585_1837 NC_012468.1 1708586 1708663 D tRNA-Lys 1708586..1708663 Streptococcus pneumoniae 70585 7684227 SP70585_1960 tRNA SP70585_1960 NC_012468.1 1822917 1823009 R tRNA-Ser complement(1822917..1823009) Streptococcus pneumoniae 70585 7684456 SP70585_1961 tRNA SP70585_1961 NC_012468.1 1823011 1823089 R tRNA-Ile complement(1823011..1823089) Streptococcus pneumoniae 70585 7683910 SP70585_1962 tRNA SP70585_1962 NC_012468.1 1823121 1823194 R tRNA-Gly complement(1823121..1823194) Streptococcus pneumoniae 70585 7683917 SP70585_1963 tRNA SP70585_1963 NC_012468.1 1823211 1823286 R tRNA-Phe complement(1823211..1823286) Streptococcus pneumoniae 70585 7684314 SP70585_1964 tRNA SP70585_1964 NC_012468.1 1823287 1823363 R tRNA-Met complement(1823287..1823363) Streptococcus pneumoniae 70585 7683907 SP70585_1965 tRNA SP70585_1965 NC_012468.1 1823374 1823466 R tRNA-Ser complement(1823374..1823466) Streptococcus pneumoniae 70585 7684304 SP70585_1966 tRNA SP70585_1966 NC_012468.1 1823474 1823550 R tRNA-Met complement(1823474..1823550) Streptococcus pneumoniae 70585 7683897 SP70585_1967 tRNA SP70585_1967 NC_012468.1 1823560 1823638 R tRNA-Met complement(1823560..1823638) Streptococcus pneumoniae 70585 7683908 SP70585_1968 tRNA SP70585_1968 NC_012468.1 1823639 1823717 R tRNA-Pro complement(1823639..1823717) Streptococcus pneumoniae 70585 7684313 SP70585_1969 tRNA SP70585_1969 NC_012468.1 1823729 1823805 R tRNA-Arg complement(1823729..1823805) Streptococcus pneumoniae 70585 7683894 SP70585_1970 tRNA SP70585_1970 NC_012468.1 1823812 1823900 R tRNA-Leu complement(1823812..1823900) Streptococcus pneumoniae 70585 7684301 SP70585_1971 tRNA SP70585_1971 NC_012468.1 1823905 1823979 R tRNA-Gly complement(1823905..1823979) Streptococcus pneumoniae 70585 7684303 SP70585_1972 tRNA SP70585_1972 NC_012468.1 1823999 1824074 R tRNA-Thr complement(1823999..1824074) Streptococcus pneumoniae 70585 7683921 SP70585_1973 tRNA SP70585_1973 NC_012468.1 1824089 1824175 R tRNA-Leu complement(1824089..1824175) Streptococcus pneumoniae 70585 7683906 SP70585_1974 tRNA SP70585_1974 NC_012468.1 1824177 1824252 R tRNA-Lys complement(1824177..1824252) Streptococcus pneumoniae 70585 7683899 SP70585_1975 tRNA SP70585_1975 NC_012468.1 1824277 1824349 R tRNA-Asp complement(1824277..1824349) Streptococcus pneumoniae 70585 7683924 SP70585_2373 tRNA SP70585_2373 NC_012468.1 1824352 1824424 R tRNA-Val complement(1824352..1824424) Streptococcus pneumoniae 70585 7683919 SP70585_1979 tRNA SP70585_1979 NC_012468.1 1827643 1827720 R tRNA-Ala complement(1827643..1827720) Streptococcus pneumoniae 70585 7684285 SP70585_1981 tRNA SP70585_1981 NC_012468.1 1829567 1829641 R tRNA-Glu complement(1829567..1829641) Streptococcus pneumoniae 70585 7684282 SP70585_2033 tRNA SP70585_2033 NC_012468.1 1875120 1875195 D tRNA-Cys 1875120..1875195 Streptococcus pneumoniae 70585 7684899 SP70585_2079 tRNA SP70585_2079 NC_012468.1 1912833 1912911 R tRNA-Pro complement(1912833..1912911) Streptococcus pneumoniae 70585 7684751 SP70585_2080 tRNA SP70585_2080 NC_012468.1 1912923 1912999 R tRNA-Arg complement(1912923..1912999) Streptococcus pneumoniae 70585 7684302 SP70585_2081 tRNA SP70585_2081 NC_012468.1 1913006 1913094 R tRNA-Leu complement(1913006..1913094) Streptococcus pneumoniae 70585 7684298 SP70585_2082 tRNA SP70585_2082 NC_012468.1 1913099 1913173 R tRNA-Gly complement(1913099..1913173) Streptococcus pneumoniae 70585 7683912 SP70585_2083 tRNA SP70585_2083 NC_012468.1 1913193 1913268 R tRNA-Thr complement(1913193..1913268) Streptococcus pneumoniae 70585 7683918 SP70585_2084 tRNA SP70585_2084 NC_012468.1 1913283 1913369 R tRNA-Leu complement(1913283..1913369) Streptococcus pneumoniae 70585 7685199 SP70585_2085 tRNA SP70585_2085 NC_012468.1 1913371 1913446 R tRNA-Lys complement(1913371..1913446) Streptococcus pneumoniae 70585 7683913 SP70585_2086 tRNA SP70585_2086 NC_012468.1 1913471 1913543 R tRNA-Asp complement(1913471..1913543) Streptococcus pneumoniae 70585 7684317 SP70585_2375 tRNA SP70585_2375 NC_012468.1 1913546 1913618 R tRNA-Val complement(1913546..1913618) Streptococcus pneumoniae 70585 7683923 SP70585_2090 tRNA SP70585_2090 NC_012468.1 1916837 1916914 R tRNA-Ala complement(1916837..1916914) Streptococcus pneumoniae 70585 7684284 SP70585_2092 tRNA SP70585_2092 NC_012468.1 1918760 1918834 R tRNA-Glu complement(1918760..1918834) Streptococcus pneumoniae 70585 7684287 SP70585_2159 tRNA SP70585_2159 NC_012468.1 1976263 1976351 R tRNA-Leu complement(1976263..1976351) Streptococcus pneumoniae 70585 7684794 SP70585_2160 tRNA SP70585_2160 NC_012468.1 1976356 1976432 R tRNA-Gln complement(1976356..1976432) Streptococcus pneumoniae 70585 7684319 SP70585_2161 tRNA SP70585_2161 NC_012468.1 1976438 1976515 R tRNA-His complement(1976438..1976515) Streptococcus pneumoniae 70585 7684312 SP70585_2162 tRNA SP70585_2162 NC_012468.1 1976529 1976601 R tRNA-Trp complement(1976529..1976601) Streptococcus pneumoniae 70585 7683916 SP70585_2374 tRNA SP70585_2374 NC_012468.1 1976604 1976684 R tRNA-Tyr complement(1976604..1976684) Streptococcus pneumoniae 70585 7683920 SP70585_2163 tRNA SP70585_2163 NC_012468.1 1976694 1976769 R tRNA-Phe complement(1976694..1976769) Streptococcus pneumoniae 70585 7683926 SP70585_2164 tRNA SP70585_2164 NC_012468.1 1976770 1976846 R tRNA-Met complement(1976770..1976846) Streptococcus pneumoniae 70585 7684306 SP70585_2165 tRNA SP70585_2165 NC_012468.1 1976854 1976946 R tRNA-Ser complement(1976854..1976946) Streptococcus pneumoniae 70585 7683922 SP70585_2166 tRNA SP70585_2166 NC_012468.1 1977025 1977103 R tRNA-Ile complement(1977025..1977103) Streptococcus pneumoniae 70585 7684315 SP70585_2167 tRNA SP70585_2167 NC_012468.1 1977133 1977208 R tRNA-Gly complement(1977133..1977208) Streptococcus pneumoniae 70585 7684311 SP70585_2168 tRNA SP70585_2168 NC_012468.1 1977210 1977285 R tRNA-Val complement(1977210..1977285) Streptococcus pneumoniae 70585 7683925 SP70585_2172 tRNA SP70585_2172 NC_012468.1 1980504 1980581 R tRNA-Ala complement(1980504..1980581) Streptococcus pneumoniae 70585 7684291 SP70585_2174 tRNA SP70585_2174 NC_012468.1 1982427 1982501 R tRNA-Glu complement(1982427..1982501) Streptococcus pneumoniae 70585 7684281 SP70585_2362 tRNA SP70585_2362 NC_012468.1 2179299 2179375 R tRNA-Asn complement(2179299..2179375) Streptococcus pneumoniae 70585 7683084 SP70585_2363 tRNA SP70585_2363 NC_012468.1 2179378 2179452 R tRNA-Glu complement(2179378..2179452) Streptococcus pneumoniae 70585 7684308 SP70585_2367 tRNA SP70585_2367 NC_012468.1 2181887 2181963 R tRNA-Arg complement(2181887..2181963) Streptococcus pneumoniae 70585 7684618 SP70585_0017 rRNA rrs1 NC_012468.1 16782 18239 D 16S ribosomal RNA 16782..18239 Streptococcus pneumoniae 70585 7683895 SP70585_0020 rRNA rrl1 NC_012468.1 18563 21464 D 23S ribosomal RNA 18563..21464 Streptococcus pneumoniae 70585 7683901 SP70585_0021 rRNA rrf1 NC_012468.1 21541 21656 D 5S ribosomal RNA 21541..21656 Streptococcus pneumoniae 70585 7684288 SP70585_1976 rRNA rrf2 NC_012468.1 1824429 1824544 R 5S ribosomal RNA complement(1824429..1824544) Streptococcus pneumoniae 70585 7684309 SP70585_1977 rRNA rrl2 NC_012468.1 1824621 1827522 R 23S ribosomal RNA complement(1824621..1827522) Streptococcus pneumoniae 70585 7684283 SP70585_1980 rRNA rrs2 NC_012468.1 1827846 1829303 R 16S ribosomal RNA complement(1827846..1829303) Streptococcus pneumoniae 70585 7684300 SP70585_2087 rRNA rrf3 NC_012468.1 1913623 1913738 R 5S ribosomal RNA complement(1913623..1913738) Streptococcus pneumoniae 70585 7683903 SP70585_2088 rRNA rrl3 NC_012468.1 1913815 1916716 R 23S ribosomal RNA complement(1913815..1916716) Streptococcus pneumoniae 70585 7684292 SP70585_2091 rRNA rrs3 NC_012468.1 1917040 1918497 R 16S ribosomal RNA complement(1917040..1918497) Streptococcus pneumoniae 70585 7683904 SP70585_2169 rRNA rrf4 NC_012468.1 1977290 1977405 R 5S ribosomal RNA complement(1977290..1977405) Streptococcus pneumoniae 70585 7683900 SP70585_2170 rRNA rrl4 NC_012468.1 1977482 1980383 R 23S ribosomal RNA complement(1977482..1980383) Streptococcus pneumoniae 70585 7684286 SP70585_2173 rRNA rrs4 NC_012468.1 1980707 1982164 R 16S ribosomal RNA complement(1980707..1982164) Streptococcus pneumoniae 70585 7684299