-- dump date   	20140620_084345
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
574093000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
574093000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
574093000003	Walker A motif; other site
574093000004	ATP binding site [chemical binding]; other site
574093000005	Walker B motif; other site
574093000006	arginine finger; other site
574093000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
574093000008	DnaA box-binding interface [nucleotide binding]; other site
574093000009	DNA polymerase III subunit beta; Validated; Region: PRK05643
574093000010	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
574093000011	putative DNA binding surface [nucleotide binding]; other site
574093000012	dimer interface [polypeptide binding]; other site
574093000013	beta-clamp/clamp loader binding surface; other site
574093000014	beta-clamp/translesion DNA polymerase binding surface; other site
574093000015	Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864
574093000016	GTP-binding protein YchF; Reviewed; Region: PRK09601
574093000017	YchF GTPase; Region: YchF; cd01900
574093000018	G1 box; other site
574093000019	GTP/Mg2+ binding site [chemical binding]; other site
574093000020	Switch I region; other site
574093000021	G2 box; other site
574093000022	Switch II region; other site
574093000023	G3 box; other site
574093000024	G4 box; other site
574093000025	G5 box; other site
574093000026	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
574093000027	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
574093000028	putative active site [active]
574093000029	catalytic residue [active]
574093000030	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
574093000031	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
574093000032	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
574093000033	ATP binding site [chemical binding]; other site
574093000034	putative Mg++ binding site [ion binding]; other site
574093000035	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
574093000036	nucleotide binding region [chemical binding]; other site
574093000037	ATP-binding site [chemical binding]; other site
574093000038	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
574093000039	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
574093000040	RNA binding surface [nucleotide binding]; other site
574093000041	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
574093000042	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
574093000043	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
574093000044	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
574093000045	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
574093000046	Ligand Binding Site [chemical binding]; other site
574093000047	TilS substrate C-terminal domain; Region: TilS_C; smart00977
574093000048	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
574093000049	active site
574093000050	ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465
574093000051	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
574093000052	Walker A motif; other site
574093000053	ATP binding site [chemical binding]; other site
574093000054	Walker B motif; other site
574093000055	arginine finger; other site
574093000056	Peptidase family M41; Region: Peptidase_M41; pfam01434
574093000057	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
574093000058	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
574093000059	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
574093000060	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
574093000061	GDP-binding site [chemical binding]; other site
574093000062	ACT binding site; other site
574093000063	IMP binding site; other site
574093000064	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
574093000065	active site
574093000066	catalytic residues [active]
574093000067	DNA binding site [nucleotide binding]
574093000068	Int/Topo IB signature motif; other site
574093000069	HIRAN domain; Region: HIRAN; pfam08797
574093000070	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
574093000071	non-specific DNA binding site [nucleotide binding]; other site
574093000072	salt bridge; other site
574093000073	sequence-specific DNA binding site [nucleotide binding]; other site
574093000074	Predicted transcriptional regulator [Transcription]; Region: COG2932
574093000075	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
574093000076	Catalytic site [active]
574093000077	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
574093000078	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
574093000079	non-specific DNA binding site [nucleotide binding]; other site
574093000080	salt bridge; other site
574093000081	sequence-specific DNA binding site [nucleotide binding]; other site
574093000082	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
574093000083	Prophage antirepressor [Transcription]; Region: COG3617
574093000084	BRO family, N-terminal domain; Region: Bro-N; smart01040
574093000085	ORF6C domain; Region: ORF6C; pfam10552
574093000086	N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; pfam09681
574093000087	Replication initiation and membrane attachment; Region: DnaB_2; cl12121
574093000088	hypothetical protein; Validated; Region: PRK08116
574093000089	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
574093000090	Walker A motif; other site
574093000091	ATP binding site [chemical binding]; other site
574093000092	Walker B motif; other site
574093000093	Protein of unknown function (DUF1642); Region: DUF1642; pfam07852
574093000094	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
574093000095	sequence-specific DNA binding site [nucleotide binding]; other site
574093000096	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
574093000097	salt bridge; other site
574093000098	phage transcriptional activator, RinA family; Region: phage_rinA; TIGR01636
574093000099	INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186
574093000100	Int/Topo IB signature motif; other site
574093000101	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
574093000102	active site
574093000103	Phage Terminase; Region: Terminase_1; pfam03354
574093000104	Phage portal protein; Region: Phage_portal; pfam04860
574093000105	Phage-related protein [Function unknown]; Region: COG4695; cl01923
574093000106	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
574093000107	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
574093000108	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
574093000109	Phage capsid family; Region: Phage_capsid; pfam05065
574093000110	Rab interacting lysosomal protein; Region: RILP; pfam11461
574093000111	Lactococcus lactis bacteriophage major structural protein; Region: L_lac_phage_MSP; pfam06488
574093000112	Centrosome localisation domain of Cep57; Region: Cep57_CLD; pfam14073
574093000113	Prefoldin is a hexameric molecular chaperone complex, found in both eukaryotes and archaea, that binds and stabilizes newly synthesized polypeptides allowing them to fold correctly.  The complex contains two alpha and four beta subunits, the two subunits...; Region: Prefoldin; cl09111
574093000114	Phage-related minor tail protein [Function unknown]; Region: COG5280
574093000115	Phage-related protein [Function unknown]; Region: COG4722
574093000116	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
574093000117	Chaperone of endosialidase; Region: Peptidase_S74; pfam13884
574093000118	toxin secretion/phage lysis holin; Region: holin_tox_secr; TIGR01593
574093000119	Phage holin protein (Holin_LLH); Region: Holin_LLH; cl09890
574093000120	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
574093000121	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
574093000122	amidase catalytic site [active]
574093000123	Zn binding residues [ion binding]; other site
574093000124	substrate binding site [chemical binding]; other site
574093000125	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
574093000126	nucleoside/Zn binding site; other site
574093000127	dimer interface [polypeptide binding]; other site
574093000128	catalytic motif [active]
574093000129	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
574093000130	trimer interface [polypeptide binding]; other site
574093000131	active site
574093000132	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
574093000133	catalytic core [active]
574093000134	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
574093000135	DNA repair protein RadA; Provisional; Region: PRK11823
574093000136	Walker A motif; other site
574093000137	ATP binding site [chemical binding]; other site
574093000138	Walker B motif; other site
574093000139	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
574093000140	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
574093000141	active site clefts [active]
574093000142	zinc binding site [ion binding]; other site
574093000143	dimer interface [polypeptide binding]; other site
574093000144	potential frameshift: common BLAST hit: gi|298501816|ref|YP_003723756.1| putative repair protein
574093000145	Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339
574093000146	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269
574093000147	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
574093000148	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
574093000149	active site
574093000150	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
574093000151	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
574093000152	DNA polymerase I; Provisional; Region: PRK05755
574093000153	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
574093000154	active site
574093000155	metal binding site 1 [ion binding]; metal-binding site
574093000156	putative 5' ssDNA interaction site; other site
574093000157	metal binding site 3; metal-binding site
574093000158	metal binding site 2 [ion binding]; metal-binding site
574093000159	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
574093000160	putative DNA binding site [nucleotide binding]; other site
574093000161	putative metal binding site [ion binding]; other site
574093000162	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
574093000163	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
574093000164	active site
574093000165	DNA binding site [nucleotide binding]
574093000166	catalytic site [active]
574093000167	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
574093000168	Predicted membrane protein [Function unknown]; Region: COG2855
574093000169	aromatic amino acid aminotransferase; Validated; Region: PRK07309
574093000170	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
574093000171	pyridoxal 5'-phosphate binding site [chemical binding]; other site
574093000172	homodimer interface [polypeptide binding]; other site
574093000173	catalytic residue [active]
574093000174	Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381
574093000175	Recombination protein O N terminal; Region: RecO_N; pfam11967
574093000176	Recombination protein O C terminal; Region: RecO_C; pfam02565
574093000177	putative phosphate acyltransferase; Provisional; Region: PRK05331
574093000178	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
574093000179	ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193
574093000180	putative active site [active]
574093000181	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
574093000182	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
574093000183	Walker A/P-loop; other site
574093000184	ATP binding site [chemical binding]; other site
574093000185	Q-loop/lid; other site
574093000186	ABC transporter signature motif; other site
574093000187	Walker B; other site
574093000188	D-loop; other site
574093000189	H-loop/switch region; other site
574093000190	bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000
574093000191	HlyD family secretion protein; Region: HlyD_3; pfam13437
574093000192	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
574093000193	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
574093000194	ATP binding site [chemical binding]; other site
574093000195	active site
574093000196	substrate binding site [chemical binding]; other site
574093000197	phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857
574093000198	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
574093000199	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
574093000200	dimerization interface [polypeptide binding]; other site
574093000201	ATP binding site [chemical binding]; other site
574093000202	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
574093000203	dimerization interface [polypeptide binding]; other site
574093000204	ATP binding site [chemical binding]; other site
574093000205	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
574093000206	putative active site [active]
574093000207	catalytic triad [active]
574093000208	amidophosphoribosyltransferase; Provisional; Region: PRK07272
574093000209	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
574093000210	active site
574093000211	tetramer interface [polypeptide binding]; other site
574093000212	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
574093000213	active site
574093000214	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
574093000215	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
574093000216	dimerization interface [polypeptide binding]; other site
574093000217	putative ATP binding site [chemical binding]; other site
574093000218	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
574093000219	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
574093000220	active site
574093000221	substrate binding site [chemical binding]; other site
574093000222	cosubstrate binding site; other site
574093000223	catalytic site [active]
574093000224	VanZ like family; Region: VanZ; pfam04892
574093000225	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
574093000226	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
574093000227	purine monophosphate binding site [chemical binding]; other site
574093000228	dimer interface [polypeptide binding]; other site
574093000229	putative catalytic residues [active]
574093000230	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
574093000231	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
574093000232	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
574093000233	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
574093000234	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
574093000235	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
574093000236	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
574093000237	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
574093000238	ATP-grasp domain; Region: ATP-grasp; pfam02222
574093000239	adenylosuccinate lyase; Provisional; Region: PRK07492
574093000240	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
574093000241	tetramer interface [polypeptide binding]; other site
574093000242	active site
574093000243	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
574093000244	N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525
574093000245	Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564
574093000246	active site
574093000247	Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564
574093000248	active site
574093000249	G5 domain; Region: G5; pfam07501
574093000250	G5 domain; Region: G5; pfam07501
574093000251	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
574093000252	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
574093000253	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
574093000254	DNA-binding site [nucleotide binding]; DNA binding site
574093000255	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
574093000256	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
574093000257	Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301
574093000258	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
574093000259	active site
574093000260	phosphorylation site [posttranslational modification]
574093000261	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
574093000262	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
574093000263	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
574093000264	active pocket/dimerization site; other site
574093000265	active site
574093000266	phosphorylation site [posttranslational modification]
574093000267	putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815
574093000268	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
574093000269	dimer interface [polypeptide binding]; other site
574093000270	active site
574093000271	AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010
574093000272	putative active site [active]
574093000273	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
574093000274	active site
574093000275	catalytic residues [active]
574093000276	SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133
574093000277	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
574093000278	G5 domain; Region: G5; pfam07501
574093000279	M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342
574093000280	The GLUG motif; Region: Glug; pfam07581
574093000281	M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580
574093000282	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
574093000283	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
574093000284	putative metal binding site [ion binding]; other site
574093000285	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
574093000286	active site
574093000287	maltose O-acetyltransferase; Provisional; Region: PRK10092
574093000288	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
574093000289	active site
574093000290	substrate binding site [chemical binding]; other site
574093000291	trimer interface [polypeptide binding]; other site
574093000292	CoA binding site [chemical binding]; other site
574093000293	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
574093000294	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
574093000295	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
574093000296	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
574093000297	TrkA-N domain; Region: TrkA_N; pfam02254
574093000298	Fibronectin-binding repeat; Region: SSURE; pfam11966
574093000299	Fibronectin-binding repeat; Region: SSURE; pfam11966
574093000300	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
574093000301	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
574093000302	active site
574093000303	phosphorylation site [posttranslational modification]
574093000304	intermolecular recognition site; other site
574093000305	dimerization interface [polypeptide binding]; other site
574093000306	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
574093000307	DNA binding site [nucleotide binding]
574093000308	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
574093000309	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
574093000310	dimerization interface [polypeptide binding]; other site
574093000311	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
574093000312	dimer interface [polypeptide binding]; other site
574093000313	phosphorylation site [posttranslational modification]
574093000314	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
574093000315	ATP binding site [chemical binding]; other site
574093000316	Mg2+ binding site [ion binding]; other site
574093000317	G-X-G motif; other site
574093000318	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
574093000319	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
574093000320	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
574093000321	RNA binding surface [nucleotide binding]; other site
574093000322	Helix-turn-helix domain; Region: HTH_28; pfam13518
574093000323	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
574093000324	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
574093000325	dimer interface [polypeptide binding]; other site
574093000326	conserved gate region; other site
574093000327	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
574093000328	ABC-ATPase subunit interface; other site
574093000329	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
574093000330	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
574093000331	dimer interface [polypeptide binding]; other site
574093000332	conserved gate region; other site
574093000333	putative PBP binding loops; other site
574093000334	ABC-ATPase subunit interface; other site
574093000335	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
574093000336	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
574093000337	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
574093000338	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
574093000339	active site residue [active]
574093000340	Protein of unknown function (DUF3650); Region: DUF3650; pfam12368
574093000341	Domain of unknown function (DUF4299); Region: DUF4299; pfam14132
574093000342	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
574093000343	Predicted membrane protein [Function unknown]; Region: COG4709
574093000344	Predicted transcriptional regulators [Transcription]; Region: COG1695
574093000345	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
574093000346	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
574093000347	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
574093000348	putative substrate translocation pore; other site
574093000349	ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525
574093000350	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
574093000351	Ligand binding site; other site
574093000352	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
574093000353	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
574093000354	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
574093000355	NAD(P) binding site [chemical binding]; other site
574093000356	homodimer interface [polypeptide binding]; other site
574093000357	substrate binding site [chemical binding]; other site
574093000358	active site
574093000359	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
574093000360	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
574093000361	active site
574093000362	motif I; other site
574093000363	motif II; other site
574093000364	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
574093000365	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
574093000366	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
574093000367	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
574093000368	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
574093000369	putative L-serine binding site [chemical binding]; other site
574093000370	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
574093000371	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
574093000372	bacteriocin, lactococcin 972 family; Region: lactococcin_972; TIGR01653
574093000373	bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654
574093000374	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
574093000375	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
574093000376	Walker A/P-loop; other site
574093000377	ATP binding site [chemical binding]; other site
574093000378	Q-loop/lid; other site
574093000379	ABC transporter signature motif; other site
574093000380	Walker B; other site
574093000381	D-loop; other site
574093000382	H-loop/switch region; other site
574093000383	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
574093000384	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
574093000385	substrate binding pocket [chemical binding]; other site
574093000386	membrane-bound complex binding site; other site
574093000387	hinge residues; other site
574093000388	argininosuccinate synthase; Provisional; Region: PRK13820
574093000389	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
574093000390	ANP binding site [chemical binding]; other site
574093000391	Substrate Binding Site II [chemical binding]; other site
574093000392	Substrate Binding Site I [chemical binding]; other site
574093000393	argininosuccinate lyase; Provisional; Region: PRK00855
574093000394	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
574093000395	active sites [active]
574093000396	tetramer interface [polypeptide binding]; other site
574093000397	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
574093000398	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
574093000399	non-specific DNA binding site [nucleotide binding]; other site
574093000400	salt bridge; other site
574093000401	sequence-specific DNA binding site [nucleotide binding]; other site
574093000402	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
574093000403	TATA element modulatory factor 1 DNA binding; Region: TMF_DNA_bd; pfam12329
574093000404	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
574093000405	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
574093000406	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
574093000407	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
574093000408	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
574093000409	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
574093000410	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
574093000411	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
574093000412	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
574093000413	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
574093000414	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
574093000415	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
574093000416	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
574093000417	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
574093000418	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
574093000419	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688
574093000420	nudix motif; other site
574093000421	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
574093000422	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
574093000423	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
574093000424	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
574093000425	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
574093000426	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
574093000427	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
574093000428	hypothetical protein; Provisional; Region: PRK13667
574093000429	class IIb bacteriocin, lactobin A/cerein 7B family; Region: bact_IIb_cerein; TIGR03949
574093000430	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
574093000431	Glycoprotease family; Region: Peptidase_M22; pfam00814
574093000432	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
574093000433	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
574093000434	Coenzyme A binding pocket [chemical binding]; other site
574093000435	UGMP family protein; Validated; Region: PRK09604
574093000436	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
574093000437	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
574093000438	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
574093000439	Transposase; Region: DDE_Tnp_ISL3; pfam01610
574093000440	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
574093000441	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
574093000442	Transposase; Region: DDE_Tnp_ISL3; pfam01610
574093000443	potential frameshift: common BLAST hit: gi|169833354|ref|YP_001693666.1| glycosyl transferase, group 1 family protein
574093000444	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
574093000445	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
574093000446	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
574093000447	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
574093000448	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
574093000449	active site
574093000450	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
574093000451	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
574093000452	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
574093000453	Walker A/P-loop; other site
574093000454	ATP binding site [chemical binding]; other site
574093000455	Q-loop/lid; other site
574093000456	ABC transporter signature motif; other site
574093000457	Walker B; other site
574093000458	D-loop; other site
574093000459	H-loop/switch region; other site
574093000460	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
574093000461	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
574093000462	Ligand Binding Site [chemical binding]; other site
574093000463	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
574093000464	DDE superfamily endonuclease; Region: DDE_4; cl17710
574093000465	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
574093000466	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
574093000467	potential frameshift: common BLAST hit: gi|182683112|ref|YP_001834859.1| UDP-glucose dehydrogenase
574093000468	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
574093000469	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
574093000470	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
574093000471	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
574093000472	non-specific DNA binding site [nucleotide binding]; other site
574093000473	salt bridge; other site
574093000474	sequence-specific DNA binding site [nucleotide binding]; other site
574093000475	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
574093000476	CAAX protease self-immunity; Region: Abi; pfam02517
574093000477	CAAX protease self-immunity; Region: Abi; pfam02517
574093000478	H+ Antiporter protein; Region: 2A0121; TIGR00900
574093000479	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
574093000480	Predicted membrane protein [Function unknown]; Region: COG4392
574093000481	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
574093000482	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
574093000483	substrate binding pocket [chemical binding]; other site
574093000484	membrane-bound complex binding site; other site
574093000485	hinge residues; other site
574093000486	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
574093000487	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
574093000488	hypothetical protein; Provisional; Region: PRK06446
574093000489	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681
574093000490	metal binding site [ion binding]; metal-binding site
574093000491	dimer interface [polypeptide binding]; other site
574093000492	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
574093000493	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
574093000494	Walker A/P-loop; other site
574093000495	ATP binding site [chemical binding]; other site
574093000496	Q-loop/lid; other site
574093000497	ABC transporter signature motif; other site
574093000498	Walker B; other site
574093000499	D-loop; other site
574093000500	H-loop/switch region; other site
574093000501	NIL domain; Region: NIL; pfam09383
574093000502	ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011
574093000503	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605
574093000504	Predicted integral membrane protein [Function unknown]; Region: COG5578
574093000505	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
574093000506	HAMP domain; Region: HAMP; pfam00672
574093000507	Histidine kinase; Region: His_kinase; pfam06580
574093000508	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
574093000509	ATP binding site [chemical binding]; other site
574093000510	Mg2+ binding site [ion binding]; other site
574093000511	G-X-G motif; other site
574093000512	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
574093000513	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
574093000514	active site
574093000515	phosphorylation site [posttranslational modification]
574093000516	intermolecular recognition site; other site
574093000517	dimerization interface [polypeptide binding]; other site
574093000518	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
574093000519	flavoprotein NrdI; Provisional; Region: PRK02551
574093000520	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
574093000521	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
574093000522	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
574093000523	LytTr DNA-binding domain; Region: LytTR; smart00850
574093000524	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
574093000525	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
574093000526	ATP binding site [chemical binding]; other site
574093000527	Mg2+ binding site [ion binding]; other site
574093000528	G-X-G motif; other site
574093000529	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
574093000530	ATP binding site [chemical binding]; other site
574093000531	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
574093000532	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
574093000533	homopentamer interface [polypeptide binding]; other site
574093000534	active site
574093000535	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
574093000536	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
574093000537	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
574093000538	dimerization interface [polypeptide binding]; other site
574093000539	active site
574093000540	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
574093000541	Lumazine binding domain; Region: Lum_binding; pfam00677
574093000542	Lumazine binding domain; Region: Lum_binding; pfam00677
574093000543	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
574093000544	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
574093000545	catalytic motif [active]
574093000546	Zn binding site [ion binding]; other site
574093000547	RibD C-terminal domain; Region: RibD_C; cl17279
574093000548	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
574093000549	RuvA N terminal domain; Region: RuvA_N; pfam01330
574093000550	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
574093000551	CAAX protease self-immunity; Region: Abi; pfam02517
574093000552	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
574093000553	putative dimer interface [polypeptide binding]; other site
574093000554	catalytic triad [active]
574093000555	Protein of unknown function (DUF1129); Region: DUF1129; cl11555
574093000556	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
574093000557	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
574093000558	Cl binding site [ion binding]; other site
574093000559	oligomer interface [polypeptide binding]; other site
574093000560	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
574093000561	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
574093000562	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
574093000563	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
574093000564	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
574093000565	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
574093000566	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
574093000567	active site
574093000568	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
574093000569	ArsC family; Region: ArsC; pfam03960
574093000570	putative catalytic residues [active]
574093000571	thiol/disulfide switch; other site
574093000572	hypothetical protein; Provisional; Region: PRK05473
574093000573	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
574093000574	hypothetical protein; Provisional; Region: PRK13678
574093000575	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
574093000576	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
574093000577	Bacterial lipoprotein; Region: DUF3642; pfam12182
574093000578	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
574093000579	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
574093000580	Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154
574093000581	putative active site [active]
574093000582	catalytic site [active]
574093000583	Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160
574093000584	putative active site [active]
574093000585	catalytic site [active]
574093000586	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
574093000587	ATP cone domain; Region: ATP-cone; pfam03477
574093000588	Class III ribonucleotide reductase; Region: RNR_III; cd01675
574093000589	effector binding site; other site
574093000590	active site
574093000591	Zn binding site [ion binding]; other site
574093000592	glycine loop; other site
574093000593	Predicted acetyltransferase [General function prediction only]; Region: COG3981
574093000594	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
574093000595	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
574093000596	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
574093000597	FeS/SAM binding site; other site
574093000598	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
574093000599	active site
574093000600	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
574093000601	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
574093000602	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
574093000603	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
574093000604	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
574093000605	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
574093000606	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
574093000607	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
574093000608	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
574093000609	putative translocon binding site; other site
574093000610	protein-rRNA interface [nucleotide binding]; other site
574093000611	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
574093000612	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
574093000613	G-X-X-G motif; other site
574093000614	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
574093000615	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
574093000616	23S rRNA interface [nucleotide binding]; other site
574093000617	5S rRNA interface [nucleotide binding]; other site
574093000618	putative antibiotic binding site [chemical binding]; other site
574093000619	L25 interface [polypeptide binding]; other site
574093000620	L27 interface [polypeptide binding]; other site
574093000621	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
574093000622	23S rRNA interface [nucleotide binding]; other site
574093000623	putative translocon interaction site; other site
574093000624	signal recognition particle (SRP54) interaction site; other site
574093000625	L23 interface [polypeptide binding]; other site
574093000626	trigger factor interaction site; other site
574093000627	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
574093000628	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
574093000629	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
574093000630	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
574093000631	RNA binding site [nucleotide binding]; other site
574093000632	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
574093000633	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
574093000634	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
574093000635	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
574093000636	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
574093000637	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
574093000638	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
574093000639	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
574093000640	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
574093000641	5S rRNA interface [nucleotide binding]; other site
574093000642	L27 interface [polypeptide binding]; other site
574093000643	23S rRNA interface [nucleotide binding]; other site
574093000644	L5 interface [polypeptide binding]; other site
574093000645	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
574093000646	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
574093000647	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
574093000648	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
574093000649	23S rRNA binding site [nucleotide binding]; other site
574093000650	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
574093000651	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
574093000652	SecY translocase; Region: SecY; pfam00344
574093000653	adenylate kinase; Reviewed; Region: adk; PRK00279
574093000654	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
574093000655	AMP-binding site [chemical binding]; other site
574093000656	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
574093000657	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
574093000658	rRNA binding site [nucleotide binding]; other site
574093000659	predicted 30S ribosome binding site; other site
574093000660	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
574093000661	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
574093000662	30S ribosomal protein S13; Region: bact_S13; TIGR03631
574093000663	30S ribosomal protein S11; Validated; Region: PRK05309
574093000664	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
574093000665	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
574093000666	alphaNTD homodimer interface [polypeptide binding]; other site
574093000667	alphaNTD - beta interaction site [polypeptide binding]; other site
574093000668	alphaNTD - beta' interaction site [polypeptide binding]; other site
574093000669	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
574093000670	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
574093000671	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
574093000672	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
574093000673	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
574093000674	catalytic core [active]
574093000675	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
574093000676	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
574093000677	dimer interface [polypeptide binding]; other site
574093000678	conserved gate region; other site
574093000679	putative PBP binding loops; other site
574093000680	ABC-ATPase subunit interface; other site
574093000681	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
574093000682	spermidine/putrescine ABC transporter ATP-binding subunit; Region: potA; TIGR01187
574093000683	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
574093000684	Q-loop/lid; other site
574093000685	ABC transporter signature motif; other site
574093000686	Walker B; other site
574093000687	D-loop; other site
574093000688	H-loop/switch region; other site
574093000689	TOBE domain; Region: TOBE_2; pfam08402
574093000690	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
574093000691	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
574093000692	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
574093000693	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
574093000694	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
574093000695	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
574093000696	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
574093000697	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
574093000698	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
574093000699	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
574093000700	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
574093000701	active site
574093000702	methionine cluster; other site
574093000703	phosphorylation site [posttranslational modification]
574093000704	metal binding site [ion binding]; metal-binding site
574093000705	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
574093000706	active site
574093000707	P-loop; other site
574093000708	phosphorylation site [posttranslational modification]
574093000709	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
574093000710	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
574093000711	Pyruvate-formate lyase [Energy production and conversion]; Region: PflD; COG1882
574093000712	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
574093000713	dimer interface [polypeptide binding]; other site
574093000714	active site
574093000715	glycine loop; other site
574093000716	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
574093000717	active site
574093000718	intersubunit interactions; other site
574093000719	catalytic residue [active]
574093000720	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
574093000721	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
574093000722	dimer interface [polypeptide binding]; other site
574093000723	active site
574093000724	metal binding site [ion binding]; metal-binding site
574093000725	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
574093000726	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
574093000727	HIGH motif; other site
574093000728	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
574093000729	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
574093000730	active site
574093000731	KMSKS motif; other site
574093000732	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
574093000733	tRNA binding surface [nucleotide binding]; other site
574093000734	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
574093000735	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
574093000736	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
574093000737	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
574093000738	Coenzyme A binding pocket [chemical binding]; other site
574093000739	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
574093000740	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
574093000741	Walker A motif; other site
574093000742	ATP binding site [chemical binding]; other site
574093000743	Walker B motif; other site
574093000744	arginine finger; other site
574093000745	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
574093000746	Bacterial protein of unknown function (DUF925); Region: DUF925; cl01435
574093000747	Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042
574093000748	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
574093000749	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
574093000750	catalytic residue [active]
574093000751	putative FPP diphosphate  binding site; other site
574093000752	putative FPP binding hydrophobic cleft; other site
574093000753	dimer interface [polypeptide binding]; other site
574093000754	putative IPP diphosphate binding site; other site
574093000755	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
574093000756	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
574093000757	RIP metalloprotease RseP; Region: TIGR00054
574093000758	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
574093000759	active site
574093000760	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
574093000761	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
574093000762	putative substrate binding region [chemical binding]; other site
574093000763	prolyl-tRNA synthetase; Provisional; Region: PRK09194
574093000764	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
574093000765	dimer interface [polypeptide binding]; other site
574093000766	motif 1; other site
574093000767	active site
574093000768	motif 2; other site
574093000769	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
574093000770	putative deacylase active site [active]
574093000771	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
574093000772	active site
574093000773	motif 3; other site
574093000774	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
574093000775	anticodon binding site; other site
574093000776	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
574093000777	beta-galactosidase; Region: BGL; TIGR03356
574093000778	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
574093000779	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
574093000780	glutaminase active site [active]
574093000781	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
574093000782	dimer interface [polypeptide binding]; other site
574093000783	active site
574093000784	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
574093000785	dimer interface [polypeptide binding]; other site
574093000786	active site
574093000787	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
574093000788	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
574093000789	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
574093000790	pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102
574093000791	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
574093000792	carbohydrate binding site [chemical binding]; other site
574093000793	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
574093000794	carbohydrate binding site [chemical binding]; other site
574093000795	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
574093000796	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
574093000797	Ca binding site [ion binding]; other site
574093000798	active site
574093000799	catalytic site [active]
574093000800	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
574093000801	S17 interaction site [polypeptide binding]; other site
574093000802	S8 interaction site; other site
574093000803	16S rRNA interaction site [nucleotide binding]; other site
574093000804	streptomycin interaction site [chemical binding]; other site
574093000805	23S rRNA interaction site [nucleotide binding]; other site
574093000806	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
574093000807	30S ribosomal protein S7; Validated; Region: PRK05302
574093000808	elongation factor G; Reviewed; Region: PRK00007
574093000809	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
574093000810	G1 box; other site
574093000811	putative GEF interaction site [polypeptide binding]; other site
574093000812	GTP/Mg2+ binding site [chemical binding]; other site
574093000813	Switch I region; other site
574093000814	G2 box; other site
574093000815	G3 box; other site
574093000816	Switch II region; other site
574093000817	G4 box; other site
574093000818	G5 box; other site
574093000819	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
574093000820	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
574093000821	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
574093000822	DNA polymerase III PolC; Validated; Region: polC; PRK00448
574093000823	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
574093000824	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
574093000825	generic binding surface II; other site
574093000826	generic binding surface I; other site
574093000827	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
574093000828	active site
574093000829	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
574093000830	active site
574093000831	catalytic site [active]
574093000832	substrate binding site [chemical binding]; other site
574093000833	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
574093000834	putative PHP Thumb interface [polypeptide binding]; other site
574093000835	active site
574093000836	addiction module antitoxin, RelB/DinJ family; Region: RelB_DinJ; TIGR02384
574093000837	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041
574093000838	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
574093000839	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
574093000840	Predicted membrane protein [Function unknown]; Region: COG2261
574093000841	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
574093000842	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
574093000843	RNA binding surface [nucleotide binding]; other site
574093000844	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
574093000845	active site
574093000846	uracil binding [chemical binding]; other site
574093000847	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
574093000848	trimer interface [polypeptide binding]; other site
574093000849	active site
574093000850	G bulge; other site
574093000851	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
574093000852	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
574093000853	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
574093000854	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
574093000855	active pocket/dimerization site; other site
574093000856	active site
574093000857	phosphorylation site [posttranslational modification]
574093000858	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
574093000859	active site
574093000860	phosphorylation site [posttranslational modification]
574093000861	ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422
574093000862	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
574093000863	NAD binding site [chemical binding]; other site
574093000864	substrate binding site [chemical binding]; other site
574093000865	catalytic Zn binding site [ion binding]; other site
574093000866	tetramer interface [polypeptide binding]; other site
574093000867	structural Zn binding site [ion binding]; other site
574093000868	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
574093000869	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
574093000870	active site
574093000871	motif I; other site
574093000872	motif II; other site
574093000873	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
574093000874	Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266
574093000875	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
574093000876	dihydropteroate synthase; Region: DHPS; TIGR01496
574093000877	substrate binding pocket [chemical binding]; other site
574093000878	dimer interface [polypeptide binding]; other site
574093000879	inhibitor binding site; inhibition site
574093000880	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
574093000881	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
574093000882	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
574093000883	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
574093000884	homodecamer interface [polypeptide binding]; other site
574093000885	GTP cyclohydrolase I; Provisional; Region: PLN03044
574093000886	active site
574093000887	putative catalytic site residues [active]
574093000888	zinc binding site [ion binding]; other site
574093000889	GTP-CH-I/GFRP interaction surface; other site
574093000890	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
574093000891	homooctamer interface [polypeptide binding]; other site
574093000892	active site
574093000893	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
574093000894	catalytic center binding site [active]
574093000895	ATP binding site [chemical binding]; other site
574093000896	Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124
574093000897	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
574093000898	23S rRNA interface [nucleotide binding]; other site
574093000899	L3 interface [polypeptide binding]; other site
574093000900	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
574093000901	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
574093000902	DNA binding site [nucleotide binding]
574093000903	active site
574093000904	Int/Topo IB signature motif; other site
574093000905	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
574093000906	This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595
574093000907	putative active site [active]
574093000908	putative catalytic site [active]
574093000909	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
574093000910	catalytic residues [active]
574093000911	dimer interface [polypeptide binding]; other site
574093000912	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
574093000913	Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083
574093000914	substrate binding site [chemical binding]; other site
574093000915	catalytic residues [active]
574093000916	Transposase IS200 like; Region: Y1_Tnp; pfam01797
574093000917	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
574093000918	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
574093000919	active site
574093000920	intersubunit interface [polypeptide binding]; other site
574093000921	catalytic residue [active]
574093000922	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
574093000923	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
574093000924	substrate binding site [chemical binding]; other site
574093000925	ATP binding site [chemical binding]; other site
574093000926	hypothetical protein; Provisional; Region: PRK09273
574093000927	Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698
574093000928	Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408
574093000929	gluconate 5-dehydrogenase; Provisional; Region: PRK07097
574093000930	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
574093000931	NADP binding site [chemical binding]; other site
574093000932	homodimer interface [polypeptide binding]; other site
574093000933	active site
574093000934	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
574093000935	active pocket/dimerization site; other site
574093000936	active site
574093000937	phosphorylation site [posttranslational modification]
574093000938	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
574093000939	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
574093000940	active site
574093000941	phosphorylation site [posttranslational modification]
574093000942	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
574093000943	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
574093000944	Preprotein translocase subunit YajC [Intracellular trafficking and secretion]; Region: YajC; COG1862
574093000945	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
574093000946	Transcriptional regulators [Transcription]; Region: PurR; COG1609
574093000947	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
574093000948	DNA binding site [nucleotide binding]
574093000949	domain linker motif; other site
574093000950	Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283
574093000951	putative dimerization interface [polypeptide binding]; other site
574093000952	putative ligand binding site [chemical binding]; other site
574093000953	Protein of unknown function (DUF3278); Region: DUF3278; pfam11683
574093000954	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
574093000955	non-specific DNA binding site [nucleotide binding]; other site
574093000956	salt bridge; other site
574093000957	sequence-specific DNA binding site [nucleotide binding]; other site
574093000958	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
574093000959	MraW methylase family; Region: Methyltransf_5; pfam01795
574093000960	Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839
574093000961	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
574093000962	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
574093000963	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
574093000964	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573
574093000965	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573
574093000966	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
574093000967	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
574093000968	Mg++ binding site [ion binding]; other site
574093000969	putative catalytic motif [active]
574093000970	putative substrate binding site [chemical binding]; other site
574093000971	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
574093000972	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
574093000973	Walker A motif; other site
574093000974	ATP binding site [chemical binding]; other site
574093000975	Walker B motif; other site
574093000976	arginine finger; other site
574093000977	UvrB/uvrC motif; Region: UVR; pfam02151
574093000978	MoxR-like ATPases [General function prediction only]; Region: COG0714
574093000979	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
574093000980	Walker A motif; other site
574093000981	ATP binding site [chemical binding]; other site
574093000982	Walker B motif; other site
574093000983	arginine finger; other site
574093000984	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
574093000985	LuxS protein involved in autoinducer AI2 synthesis [Signal transduction mechanisms]; Region: LuxS; COG1854
574093000986	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868
574093000987	hypothetical protein; Provisional; Region: PRK13663
574093000988	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
574093000989	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
574093000990	Ca binding site [ion binding]; other site
574093000991	active site
574093000992	catalytic site [active]
574093000993	Helix-turn-helix domain; Region: HTH_28; pfam13518
574093000994	Winged helix-turn helix; Region: HTH_29; pfam13551
574093000995	Homeodomain-like domain; Region: HTH_32; pfam13565
574093000996	Integrase core domain; Region: rve; pfam00665
574093000997	DNA polymerase processivity factor; Region: DNA_PPF; pfam02916
574093000998	Transcriptional regulator [Transcription]; Region: LytR; COG1316
574093000999	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
574093001000	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
574093001001	polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006
574093001002	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
574093001003	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
574093001004	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
574093001005	Bacterial sugar transferase; Region: Bac_transf; pfam02397
574093001006	Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660
574093001007	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; pfam04101
574093001008	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
574093001009	This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812
574093001010	putative ADP-binding pocket [chemical binding]; other site
574093001011	Domain of unknown function (DUF1919); Region: DUF1919; pfam08942
574093001012	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
574093001013	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
574093001014	O-Antigen ligase; Region: Wzy_C; pfam04932
574093001015	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
574093001016	putative trimer interface [polypeptide binding]; other site
574093001017	putative CoA binding site [chemical binding]; other site
574093001018	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
574093001019	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
574093001020	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
574093001021	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
574093001022	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
574093001023	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
574093001024	active site
574093001025	nucleotide binding site [chemical binding]; other site
574093001026	HIGH motif; other site
574093001027	KMSKS motif; other site
574093001028	Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594
574093001029	Acyltransferase family; Region: Acyl_transf_3; pfam01757
574093001030	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
574093001031	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
574093001032	peptide binding site [polypeptide binding]; other site
574093001033	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
574093001034	Endo-alpha-N-acetylgalactosaminidase; Region: Glyco_hydro_101; pfam12905
574093001035	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
574093001036	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
574093001037	Transglycosylase; Region: Transgly; pfam00912
574093001038	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
574093001039	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
574093001040	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
574093001041	hypothetical protein; Provisional; Region: PRK13660
574093001042	cell division protein GpsB; Provisional; Region: PRK14127
574093001043	DivIVA domain; Region: DivI1A_domain; TIGR03544
574093001044	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
574093001045	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
574093001046	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
574093001047	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
574093001048	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
574093001049	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
574093001050	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
574093001051	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
574093001052	active site
574093001053	phosphorylation site [posttranslational modification]
574093001054	intermolecular recognition site; other site
574093001055	dimerization interface [polypeptide binding]; other site
574093001056	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
574093001057	DNA binding site [nucleotide binding]
574093001058	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
574093001059	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
574093001060	active site
574093001061	zinc binding site [ion binding]; other site
574093001062	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
574093001063	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340
574093001064	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
574093001065	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
574093001066	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
574093001067	Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407
574093001068	diphosphomevalonate decarboxylase; Region: PLN02407
574093001069	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
574093001070	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
574093001071	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
574093001072	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
574093001073	homotetramer interface [polypeptide binding]; other site
574093001074	FMN binding site [chemical binding]; other site
574093001075	homodimer contacts [polypeptide binding]; other site
574093001076	putative active site [active]
574093001077	putative substrate binding site [chemical binding]; other site
574093001078	Predicted membrane protein [Function unknown]; Region: COG4758
574093001079	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
574093001080	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
574093001081	Histidine kinase; Region: HisKA_3; pfam07730
574093001082	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
574093001083	ATP binding site [chemical binding]; other site
574093001084	Mg2+ binding site [ion binding]; other site
574093001085	G-X-G motif; other site
574093001086	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
574093001087	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
574093001088	active site
574093001089	phosphorylation site [posttranslational modification]
574093001090	intermolecular recognition site; other site
574093001091	dimerization interface [polypeptide binding]; other site
574093001092	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
574093001093	DNA binding residues [nucleotide binding]
574093001094	dimerization interface [polypeptide binding]; other site
574093001095	A new structural DNA glycosylase; Region: AlkD_like; cl11434
574093001096	A new structural DNA glycosylase; Region: AlkD_like; cl11434
574093001097	V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591
574093001098	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
574093001099	DNA binding site [nucleotide binding]
574093001100	active site
574093001101	Int/Topo IB signature motif; other site
574093001102	trigger factor; Provisional; Region: tig; PRK01490
574093001103	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
574093001104	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
574093001105	potential frameshift: common BLAST hit: gi|225853977|ref|YP_002735489.1| helicase, RecD/TraA family
574093001106	Family description; Region: UvrD_C_2; pfam13538
574093001107	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
574093001108	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
574093001109	DNA binding site [nucleotide binding]
574093001110	AAA domain; Region: AAA_30; pfam13604
574093001111	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
574093001112	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
574093001113	Catalytic site [active]
574093001114	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
574093001115	ribonuclease HIII; Provisional; Region: PRK00996
574093001116	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
574093001117	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
574093001118	RNA/DNA hybrid binding site [nucleotide binding]; other site
574093001119	active site
574093001120	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
574093001121	Colicin V production protein; Region: Colicin_V; pfam02674
574093001122	Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: COG1193
574093001123	MutS domain III; Region: MutS_III; pfam05192
574093001124	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
574093001125	Walker A/P-loop; other site
574093001126	ATP binding site [chemical binding]; other site
574093001127	Q-loop/lid; other site
574093001128	ABC transporter signature motif; other site
574093001129	Walker B; other site
574093001130	D-loop; other site
574093001131	H-loop/switch region; other site
574093001132	Smr domain; Region: Smr; pfam01713
574093001133	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
574093001134	amino acid carrier protein; Region: agcS; TIGR00835
574093001135	Uncharacterized conserved protein [Function unknown]; Region: COG2128
574093001136	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
574093001137	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
574093001138	C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325
574093001139	gating phenylalanine in ion channel; other site
574093001140	seryl-tRNA synthetase; Provisional; Region: PRK05431
574093001141	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
574093001142	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
574093001143	dimer interface [polypeptide binding]; other site
574093001144	active site
574093001145	motif 1; other site
574093001146	motif 2; other site
574093001147	motif 3; other site
574093001148	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4687
574093001149	aspartate kinase; Reviewed; Region: PRK09034
574093001150	AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245
574093001151	putative catalytic residues [active]
574093001152	putative nucleotide binding site [chemical binding]; other site
574093001153	putative aspartate binding site [chemical binding]; other site
574093001154	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
574093001155	allosteric regulatory residue; other site
574093001156	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
574093001157	enoyl-CoA hydratase; Provisional; Region: PRK07260
574093001158	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
574093001159	substrate binding site [chemical binding]; other site
574093001160	oxyanion hole (OAH) forming residues; other site
574093001161	trimer interface [polypeptide binding]; other site
574093001162	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
574093001163	MarR family; Region: MarR_2; pfam12802
574093001164	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
574093001165	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
574093001166	dimer interface [polypeptide binding]; other site
574093001167	active site
574093001168	CoA binding pocket [chemical binding]; other site
574093001169	acyl carrier protein; Provisional; Region: acpP; PRK00982
574093001170	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
574093001171	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
574093001172	FMN binding site [chemical binding]; other site
574093001173	substrate binding site [chemical binding]; other site
574093001174	putative catalytic residue [active]
574093001175	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
574093001176	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
574093001177	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
574093001178	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
574093001179	NAD(P) binding site [chemical binding]; other site
574093001180	homotetramer interface [polypeptide binding]; other site
574093001181	homodimer interface [polypeptide binding]; other site
574093001182	active site
574093001183	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
574093001184	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
574093001185	dimer interface [polypeptide binding]; other site
574093001186	active site
574093001187	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
574093001188	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
574093001189	carboxyltransferase (CT) interaction site; other site
574093001190	biotinylation site [posttranslational modification]; other site
574093001191	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
574093001192	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
574093001193	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
574093001194	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
574093001195	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
574093001196	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
574093001197	Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571
574093001198	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
574093001199	acetyl-CoA carboxylase subunit alpha; Provisional; Region: PRK12319
574093001200	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
574093001201	putative RNA binding site [nucleotide binding]; other site
574093001202	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
574093001203	elongation factor P; Validated; Region: PRK00529
574093001204	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
574093001205	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
574093001206	RNA binding site [nucleotide binding]; other site
574093001207	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
574093001208	RNA binding site [nucleotide binding]; other site
574093001209	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
574093001210	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
574093001211	GatB domain; Region: GatB_Yqey; pfam02637
574093001212	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
574093001213	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
574093001214	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
574093001215	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
574093001216	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
574093001217	G1 box; other site
574093001218	putative GEF interaction site [polypeptide binding]; other site
574093001219	GTP/Mg2+ binding site [chemical binding]; other site
574093001220	Switch I region; other site
574093001221	G2 box; other site
574093001222	G3 box; other site
574093001223	Switch II region; other site
574093001224	G4 box; other site
574093001225	G5 box; other site
574093001226	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
574093001227	Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442
574093001228	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
574093001229	active site
574093001230	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
574093001231	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
574093001232	Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461
574093001233	DAK2 domain; Region: Dak2; pfam02734
574093001234	acetolactate synthase catalytic subunit; Reviewed; Region: PRK07282
574093001235	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
574093001236	PYR/PP interface [polypeptide binding]; other site
574093001237	dimer interface [polypeptide binding]; other site
574093001238	TPP binding site [chemical binding]; other site
574093001239	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
574093001240	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
574093001241	TPP-binding site [chemical binding]; other site
574093001242	dimer interface [polypeptide binding]; other site
574093001243	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
574093001244	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
574093001245	putative valine binding site [chemical binding]; other site
574093001246	dimer interface [polypeptide binding]; other site
574093001247	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
574093001248	ketol-acid reductoisomerase; Provisional; Region: PRK05479
574093001249	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
574093001250	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
574093001251	threonine dehydratase; Validated; Region: PRK08639
574093001252	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
574093001253	tetramer interface [polypeptide binding]; other site
574093001254	pyridoxal 5'-phosphate binding site [chemical binding]; other site
574093001255	catalytic residue [active]
574093001256	C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585
574093001257	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
574093001258	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
574093001259	Walker A/P-loop; other site
574093001260	ATP binding site [chemical binding]; other site
574093001261	Q-loop/lid; other site
574093001262	ABC transporter signature motif; other site
574093001263	Walker B; other site
574093001264	D-loop; other site
574093001265	H-loop/switch region; other site
574093001266	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
574093001267	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
574093001268	substrate binding pocket [chemical binding]; other site
574093001269	membrane-bound complex binding site; other site
574093001270	hinge residues; other site
574093001271	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
574093001272	dimer interface [polypeptide binding]; other site
574093001273	conserved gate region; other site
574093001274	putative PBP binding loops; other site
574093001275	ABC-ATPase subunit interface; other site
574093001276	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
574093001277	potential frameshift: common BLAST hit: gi|194397274|ref|YP_002037553.1| transposase
574093001278	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
574093001279	Transposase; Region: DEDD_Tnp_IS110; pfam01548
574093001280	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
574093001281	Transposase; Region: DEDD_Tnp_IS110; pfam01548
574093001282	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
574093001283	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
574093001284	active site
574093001285	DNA polymerase IV; Validated; Region: PRK02406
574093001286	DNA binding site [nucleotide binding]
574093001287	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
574093001288	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
574093001289	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
574093001290	Transcriptional regulators [Transcription]; Region: MarR; COG1846
574093001291	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
574093001292	non-specific DNA interactions [nucleotide binding]; other site
574093001293	DNA binding site [nucleotide binding]
574093001294	sequence specific DNA binding site [nucleotide binding]; other site
574093001295	putative cAMP binding site [chemical binding]; other site
574093001296	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
574093001297	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
574093001298	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
574093001299	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
574093001300	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
574093001301	methionine cluster; other site
574093001302	active site
574093001303	phosphorylation site [posttranslational modification]
574093001304	metal binding site [ion binding]; metal-binding site
574093001305	6-phospho-beta-galactosidase; Provisional; Region: PRK13511
574093001306	beta-galactosidase; Region: BGL; TIGR03356
574093001307	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
574093001308	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
574093001309	PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565
574093001310	active site
574093001311	P-loop; other site
574093001312	phosphorylation site [posttranslational modification]
574093001313	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
574093001314	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
574093001315	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
574093001316	TrkA-N domain; Region: TrkA_N; pfam02254
574093001317	TrkA-C domain; Region: TrkA_C; pfam02080
574093001318	TrkA-N domain; Region: TrkA_N; pfam02254
574093001319	TrkA-C domain; Region: TrkA_C; pfam02080
574093001320	Uncharacterized conserved protein [Function unknown]; Region: COG1912
574093001321	hypothetical protein; Provisional; Region: PRK13661
574093001322	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
574093001323	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
574093001324	Walker A/P-loop; other site
574093001325	ATP binding site [chemical binding]; other site
574093001326	Q-loop/lid; other site
574093001327	ABC transporter signature motif; other site
574093001328	Walker B; other site
574093001329	D-loop; other site
574093001330	H-loop/switch region; other site
574093001331	ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558
574093001332	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
574093001333	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
574093001334	Walker A/P-loop; other site
574093001335	ATP binding site [chemical binding]; other site
574093001336	Q-loop/lid; other site
574093001337	ABC transporter signature motif; other site
574093001338	Walker B; other site
574093001339	D-loop; other site
574093001340	H-loop/switch region; other site
574093001341	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
574093001342	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
574093001343	Predicted membrane protein [Function unknown]; Region: COG3601
574093001344	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
574093001345	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
574093001346	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
574093001347	active site
574093001348	ParB-like nuclease domain; Region: ParBc; cl02129
574093001349	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
574093001350	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
574093001351	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066
574093001352	CTP synthetase; Validated; Region: pyrG; PRK05380
574093001353	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
574093001354	Catalytic site [active]
574093001355	active site
574093001356	UTP binding site [chemical binding]; other site
574093001357	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
574093001358	active site
574093001359	putative oxyanion hole; other site
574093001360	catalytic triad [active]
574093001361	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
574093001362	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
574093001363	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
574093001364	PhoU domain; Region: PhoU; pfam01895
574093001365	PhoU domain; Region: PhoU; pfam01895
574093001366	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
574093001367	Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724
574093001368	Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins.  The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with...; Region: GH85_ENGase; cd06547
574093001369	putative active site [active]
574093001370	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
574093001371	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
574093001372	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
574093001373	G5 domain; Region: G5; pfam07501
574093001374	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
574093001375	Phosphoglycerate kinase; Region: PGK; pfam00162
574093001376	substrate binding site [chemical binding]; other site
574093001377	hinge regions; other site
574093001378	ADP binding site [chemical binding]; other site
574093001379	catalytic site [active]
574093001380	Predicted membrane protein [Function unknown]; Region: COG4129
574093001381	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
574093001382	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
574093001383	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
574093001384	DNA binding residues [nucleotide binding]
574093001385	putative dimer interface [polypeptide binding]; other site
574093001386	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
574093001387	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
574093001388	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
574093001389	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
574093001390	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
574093001391	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
574093001392	VanD integrase, IntD, and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases including those similar to IntD, a putative integrase-like protein, a component...; Region: INT_VanD; cd01196
574093001393	Int/Topo IB signature motif; other site
574093001394	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
574093001395	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
574093001396	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
574093001397	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
574093001398	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
574093001399	HsdM N-terminal domain; Region: HsdM_N; pfam12161
574093001400	Methyltransferase domain; Region: Methyltransf_26; pfam13659
574093001401	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
574093001402	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
574093001403	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
574093001404	ATP binding site [chemical binding]; other site
574093001405	putative Mg++ binding site [ion binding]; other site
574093001406	Protein of unknown function (DUF2812); Region: DUF2812; pfam11193
574093001407	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
574093001408	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
574093001409	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
574093001410	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
574093001411	dimer interface [polypeptide binding]; other site
574093001412	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
574093001413	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
574093001414	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
574093001415	nucleotide binding site [chemical binding]; other site
574093001416	NEF interaction site [polypeptide binding]; other site
574093001417	SBD interface [polypeptide binding]; other site
574093001418	chaperone protein DnaJ; Provisional; Region: PRK14276
574093001419	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
574093001420	HSP70 interaction site [polypeptide binding]; other site
574093001421	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
574093001422	substrate binding site [polypeptide binding]; other site
574093001423	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
574093001424	Zn binding sites [ion binding]; other site
574093001425	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
574093001426	substrate binding site [polypeptide binding]; other site
574093001427	dimer interface [polypeptide binding]; other site
574093001428	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
574093001429	HIT family signature motif; other site
574093001430	catalytic residue [active]
574093001431	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
574093001432	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
574093001433	Walker A/P-loop; other site
574093001434	ATP binding site [chemical binding]; other site
574093001435	Q-loop/lid; other site
574093001436	ABC transporter signature motif; other site
574093001437	Walker B; other site
574093001438	D-loop; other site
574093001439	H-loop/switch region; other site
574093001440	Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542
574093001441	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
574093001442	LytTr DNA-binding domain; Region: LytTR; pfam04397
574093001443	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
574093001444	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
574093001445	active site
574093001446	phosphorylation site [posttranslational modification]
574093001447	intermolecular recognition site; other site
574093001448	dimerization interface [polypeptide binding]; other site
574093001449	LytTr DNA-binding domain; Region: LytTR; pfam04397
574093001450	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
574093001451	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
574093001452	ATP binding site [chemical binding]; other site
574093001453	Mg2+ binding site [ion binding]; other site
574093001454	G-X-G motif; other site
574093001455	COMC family; Region: ComC; pfam03047
574093001456	bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000
574093001457	HlyD family secretion protein; Region: HlyD_3; pfam13437
574093001458	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
574093001459	ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193
574093001460	putative active site [active]
574093001461	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
574093001462	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
574093001463	Walker A/P-loop; other site
574093001464	ATP binding site [chemical binding]; other site
574093001465	Q-loop/lid; other site
574093001466	ABC transporter signature motif; other site
574093001467	Walker B; other site
574093001468	D-loop; other site
574093001469	H-loop/switch region; other site
574093001470	Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439
574093001471	CAAX protease self-immunity; Region: Abi; pfam02517
574093001472	CAAX protease self-immunity; Region: Abi; pfam02517
574093001473	Phosphotransferase enzyme family; Region: APH; pfam01636
574093001474	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
574093001475	substrate binding site [chemical binding]; other site
574093001476	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
574093001477	S-adenosylmethionine binding site [chemical binding]; other site
574093001478	Uncharacterized BCR, YhbC family COG0779; Region: DUF150; pfam02576
574093001479	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
574093001480	putative oligomer interface [polypeptide binding]; other site
574093001481	putative RNA binding site [nucleotide binding]; other site
574093001482	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
574093001483	NusA N-terminal domain; Region: NusA_N; pfam08529
574093001484	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
574093001485	RNA binding site [nucleotide binding]; other site
574093001486	homodimer interface [polypeptide binding]; other site
574093001487	NusA-like KH domain; Region: KH_5; pfam13184
574093001488	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
574093001489	G-X-X-G motif; other site
574093001490	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
574093001491	putative RNA binding cleft [nucleotide binding]; other site
574093001492	hypothetical protein; Provisional; Region: PRK07283
574093001493	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
574093001494	translation initiation factor IF-2; Region: IF-2; TIGR00487
574093001495	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
574093001496	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
574093001497	G1 box; other site
574093001498	putative GEF interaction site [polypeptide binding]; other site
574093001499	GTP/Mg2+ binding site [chemical binding]; other site
574093001500	Switch I region; other site
574093001501	G2 box; other site
574093001502	G3 box; other site
574093001503	Switch II region; other site
574093001504	G4 box; other site
574093001505	G5 box; other site
574093001506	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
574093001507	Translation-initiation factor 2; Region: IF-2; pfam11987
574093001508	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
574093001509	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
574093001510	Domain of unknown function (DUF1858); Region: DUF1858; pfam08984
574093001511	Uncharacterized conserved protein [Function unknown]; Region: COG2461
574093001512	Family of unknown function (DUF438); Region: DUF438; pfam04282
574093001513	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
574093001514	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
574093001515	putative active site [active]
574093001516	heme pocket [chemical binding]; other site
574093001517	Domain of unknown function (DUF1912); Region: DUF1912; pfam08930
574093001518	hypothetical protein; Provisional; Region: PRK07758
574093001519	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
574093001520	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
574093001521	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
574093001522	Coenzyme A binding pocket [chemical binding]; other site
574093001523	AAA domain; Region: AAA_18; pfam13238
574093001524	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
574093001525	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
574093001526	active site
574093001527	HIGH motif; other site
574093001528	nucleotide binding site [chemical binding]; other site
574093001529	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
574093001530	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
574093001531	active site
574093001532	KMSKS motif; other site
574093001533	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
574093001534	tRNA binding surface [nucleotide binding]; other site
574093001535	anticodon binding site; other site
574093001536	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
574093001537	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
574093001538	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
574093001539	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
574093001540	DDE superfamily endonuclease; Region: DDE_4; cl17710
574093001541	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
574093001542	potential frameshift: common BLAST hit: gi|289167267|ref|YP_003445534.1| DNA or RNA helicases of superfamily II
574093001543	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
574093001544	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
574093001545	putative Mg++ binding site [ion binding]; other site
574093001546	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
574093001547	nucleotide binding region [chemical binding]; other site
574093001548	ATP-binding site [chemical binding]; other site
574093001549	C-terminal putative phospholipase D-like domain of uncharacterized prokaryotic HKD family nucleases fused to DEAD/DEAH box helicases; Region: PLDc_C_DEXD_like; cd09126
574093001550	transcriptional antiterminator BglG; Provisional; Region: PRK09772
574093001551	CAT RNA binding domain; Region: CAT_RBD; smart01061
574093001552	PRD domain; Region: PRD; pfam00874
574093001553	PRD domain; Region: PRD; pfam00874
574093001554	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
574093001555	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
574093001556	active site turn [active]
574093001557	phosphorylation site [posttranslational modification]
574093001558	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
574093001559	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
574093001560	HPr interaction site; other site
574093001561	glycerol kinase (GK) interaction site [polypeptide binding]; other site
574093001562	active site
574093001563	phosphorylation site [posttranslational modification]
574093001564	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
574093001565	beta-galactosidase; Region: BGL; TIGR03356
574093001566	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
574093001567	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
574093001568	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
574093001569	dimer interface [polypeptide binding]; other site
574093001570	motif 1; other site
574093001571	active site
574093001572	motif 2; other site
574093001573	motif 3; other site
574093001574	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
574093001575	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
574093001576	Coenzyme A binding pocket [chemical binding]; other site
574093001577	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
574093001578	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
574093001579	putative tRNA-binding site [nucleotide binding]; other site
574093001580	B3/4 domain; Region: B3_4; pfam03483
574093001581	tRNA synthetase B5 domain; Region: B5; smart00874
574093001582	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
574093001583	dimer interface [polypeptide binding]; other site
574093001584	motif 1; other site
574093001585	motif 3; other site
574093001586	motif 2; other site
574093001587	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
574093001588	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
574093001589	putative catalytic site [active]
574093001590	putative metal binding site [ion binding]; other site
574093001591	putative phosphate binding site [ion binding]; other site
574093001592	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
574093001593	Helix-turn-helix domain; Region: HTH_38; pfam13936
574093001594	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
574093001595	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
574093001596	non-specific DNA binding site [nucleotide binding]; other site
574093001597	salt bridge; other site
574093001598	sequence-specific DNA binding site [nucleotide binding]; other site
574093001599	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
574093001600	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
574093001601	THF binding site; other site
574093001602	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
574093001603	substrate binding site [chemical binding]; other site
574093001604	THF binding site; other site
574093001605	zinc-binding site [ion binding]; other site
574093001606	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
574093001607	FAD binding site [chemical binding]; other site
574093001608	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
574093001609	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
574093001610	RNase E interface [polypeptide binding]; other site
574093001611	trimer interface [polypeptide binding]; other site
574093001612	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
574093001613	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
574093001614	RNase E interface [polypeptide binding]; other site
574093001615	trimer interface [polypeptide binding]; other site
574093001616	active site
574093001617	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
574093001618	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
574093001619	RNA binding site [nucleotide binding]; other site
574093001620	domain interface; other site
574093001621	serine O-acetyltransferase; Region: cysE; TIGR01172
574093001622	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
574093001623	trimer interface [polypeptide binding]; other site
574093001624	active site
574093001625	substrate binding site [chemical binding]; other site
574093001626	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
574093001627	Coenzyme A binding pocket [chemical binding]; other site
574093001628	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
574093001629	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
574093001630	Coenzyme A binding pocket [chemical binding]; other site
574093001631	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
574093001632	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
574093001633	active site
574093001634	HIGH motif; other site
574093001635	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
574093001636	KMSKS motif; other site
574093001637	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
574093001638	tRNA binding surface [nucleotide binding]; other site
574093001639	anticodon binding site; other site
574093001640	Ribonuclease III family protein [Replication, recombination, and    repair]; Region: COG1939
574093001641	active site
574093001642	metal binding site [ion binding]; metal-binding site
574093001643	dimerization interface [polypeptide binding]; other site
574093001644	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
574093001645	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
574093001646	hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264
574093001647	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
574093001648	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
574093001649	FtsX-like permease family; Region: FtsX; pfam02687
574093001650	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
574093001651	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
574093001652	Walker A/P-loop; other site
574093001653	ATP binding site [chemical binding]; other site
574093001654	Q-loop/lid; other site
574093001655	ABC transporter signature motif; other site
574093001656	Walker B; other site
574093001657	D-loop; other site
574093001658	H-loop/switch region; other site
574093001659	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
574093001660	FtsX-like permease family; Region: FtsX; pfam02687
574093001661	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
574093001662	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
574093001663	active site
574093001664	phosphorylation site [posttranslational modification]
574093001665	intermolecular recognition site; other site
574093001666	dimerization interface [polypeptide binding]; other site
574093001667	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
574093001668	DNA binding site [nucleotide binding]
574093001669	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
574093001670	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
574093001671	dimerization interface [polypeptide binding]; other site
574093001672	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
574093001673	dimer interface [polypeptide binding]; other site
574093001674	phosphorylation site [posttranslational modification]
574093001675	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
574093001676	ATP binding site [chemical binding]; other site
574093001677	Mg2+ binding site [ion binding]; other site
574093001678	G-X-G motif; other site
574093001679	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
574093001680	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
574093001681	intersubunit interface [polypeptide binding]; other site
574093001682	active site
574093001683	zinc binding site [ion binding]; other site
574093001684	Na+ binding site [ion binding]; other site
574093001685	Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097
574093001686	Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794
574093001687	NAD(P) binding domain of  ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198
574093001688	FAD binding pocket [chemical binding]; other site
574093001689	FAD binding motif [chemical binding]; other site
574093001690	phosphate binding motif [ion binding]; other site
574093001691	beta-alpha-beta structure motif; other site
574093001692	NAD binding pocket [chemical binding]; other site
574093001693	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
574093001694	dimer interface [polypeptide binding]; other site
574093001695	conserved gate region; other site
574093001696	putative PBP binding loops; other site
574093001697	ABC-ATPase subunit interface; other site
574093001698	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
574093001699	dimer interface [polypeptide binding]; other site
574093001700	conserved gate region; other site
574093001701	putative PBP binding loops; other site
574093001702	ABC-ATPase subunit interface; other site
574093001703	bifunctional adhesin/ABC transporter aspartate/glutamate-binding protein; Reviewed; Region: PRK11917
574093001704	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
574093001705	substrate binding pocket [chemical binding]; other site
574093001706	membrane-bound complex binding site; other site
574093001707	hinge residues; other site
574093001708	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
574093001709	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
574093001710	Walker A/P-loop; other site
574093001711	ATP binding site [chemical binding]; other site
574093001712	Q-loop/lid; other site
574093001713	ABC transporter signature motif; other site
574093001714	Walker B; other site
574093001715	D-loop; other site
574093001716	H-loop/switch region; other site
574093001717	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
574093001718	DHH family; Region: DHH; pfam01368
574093001719	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199
574093001720	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
574093001721	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
574093001722	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
574093001723	Predicted esterase [General function prediction only]; Region: COG0627
574093001724	S-formylglutathione hydrolase; Region: PLN02442
574093001725	Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348
574093001726	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
574093001727	FemAB family; Region: FemAB; pfam02388
574093001728	Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268
574093001729	active site
574093001730	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
574093001731	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
574093001732	GIY-YIG motif/motif A; other site
574093001733	active site
574093001734	catalytic site [active]
574093001735	putative DNA binding site [nucleotide binding]; other site
574093001736	metal binding site [ion binding]; metal-binding site
574093001737	UvrB/uvrC motif; Region: UVR; pfam02151
574093001738	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
574093001739	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
574093001740	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
574093001741	active site
574093001742	metal binding site [ion binding]; metal-binding site
574093001743	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
574093001744	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
574093001745	substrate binding pocket [chemical binding]; other site
574093001746	membrane-bound complex binding site; other site
574093001747	hinge residues; other site
574093001748	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
574093001749	dimer interface [polypeptide binding]; other site
574093001750	FMN binding site [chemical binding]; other site
574093001751	dipeptidase PepV; Reviewed; Region: PRK07318
574093001752	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
574093001753	active site
574093001754	metal binding site [ion binding]; metal-binding site
574093001755	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
574093001756	putative uracil binding site [chemical binding]; other site
574093001757	putative active site [active]
574093001758	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
574093001759	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
574093001760	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
574093001761	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
574093001762	putative oligomer interface [polypeptide binding]; other site
574093001763	putative active site [active]
574093001764	metal binding site [ion binding]; metal-binding site
574093001765	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
574093001766	nucleotide binding site/active site [active]
574093001767	HIT family signature motif; other site
574093001768	catalytic residue [active]
574093001769	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
574093001770	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
574093001771	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
574093001772	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
574093001773	23S rRNA interface [nucleotide binding]; other site
574093001774	L7/L12 interface [polypeptide binding]; other site
574093001775	putative thiostrepton binding site; other site
574093001776	L25 interface [polypeptide binding]; other site
574093001777	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
574093001778	mRNA/rRNA interface [nucleotide binding]; other site
574093001779	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
574093001780	Transposase; Region: DDE_Tnp_ISL3; pfam01610
574093001781	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
574093001782	Transposase; Region: DDE_Tnp_ISL3; pfam01610
574093001783	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251
574093001784	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
574093001785	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
574093001786	Walker A/P-loop; other site
574093001787	ATP binding site [chemical binding]; other site
574093001788	Q-loop/lid; other site
574093001789	ABC transporter signature motif; other site
574093001790	Walker B; other site
574093001791	D-loop; other site
574093001792	H-loop/switch region; other site
574093001793	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
574093001794	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
574093001795	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG3694
574093001796	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
574093001797	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
574093001798	putative active site [active]
574093001799	catalytic triad [active]
574093001800	PA_2: Protease-associated (PA) domain subgroup 2. A subgroup of PA-domain containing proteins. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is...; Region: PA_2; cd04819
574093001801	PA/protease or protease-like domain interface [polypeptide binding]; other site
574093001802	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
574093001803	catalytic residues [active]
574093001804	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
574093001805	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
574093001806	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
574093001807	active site
574093001808	phosphorylation site [posttranslational modification]
574093001809	Phosphotransferase system, galactitol-specific IIB component [Carbohydrate transport and metabolism]; Region: SgaB; COG3414
574093001810	active site
574093001811	P-loop; other site
574093001812	phosphorylation site [posttranslational modification]
574093001813	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
574093001814	PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611
574093001815	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
574093001816	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
574093001817	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
574093001818	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
574093001819	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
574093001820	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
574093001821	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
574093001822	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
574093001823	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
574093001824	G5 domain; Region: G5; pfam07501
574093001825	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
574093001826	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
574093001827	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666
574093001828	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
574093001829	Protein of unknown function (DUF3397); Region: DUF3397; pfam11877
574093001830	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
574093001831	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
574093001832	Putative rRNA methylase; Region: rRNA_methylase; pfam06962
574093001833	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
574093001834	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
574093001835	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
574093001836	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
574093001837	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
574093001838	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
574093001839	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
574093001840	catalytic residues [active]
574093001841	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
574093001842	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
574093001843	SelR domain; Region: SelR; pfam01641
574093001844	Response regulator receiver domain; Region: Response_reg; pfam00072
574093001845	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
574093001846	active site
574093001847	phosphorylation site [posttranslational modification]
574093001848	intermolecular recognition site; other site
574093001849	dimerization interface [polypeptide binding]; other site
574093001850	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
574093001851	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
574093001852	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
574093001853	Cache domain; Region: Cache_1; pfam02743
574093001854	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
574093001855	dimerization interface [polypeptide binding]; other site
574093001856	Histidine kinase; Region: His_kinase; pfam06580
574093001857	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
574093001858	ATP binding site [chemical binding]; other site
574093001859	Mg2+ binding site [ion binding]; other site
574093001860	G-X-G motif; other site
574093001861	hypothetical protein; Provisional; Region: PRK13690
574093001862	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
574093001863	G5 domain; Region: G5; pfam07501
574093001864	G5 domain; Region: G5; pfam07501
574093001865	M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342
574093001866	M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580
574093001867	aminodeoxychorismate synthase; Provisional; Region: PRK07508
574093001868	aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553
574093001869	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
574093001870	substrate-cofactor binding pocket; other site
574093001871	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
574093001872	pyridoxal 5'-phosphate binding site [chemical binding]; other site
574093001873	catalytic residue [active]
574093001874	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
574093001875	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
574093001876	Excalibur calcium-binding domain; Region: Excalibur; smart00894
574093001877	Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553
574093001878	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
574093001879	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
574093001880	nucleotide binding site [chemical binding]; other site
574093001881	thymidylate synthase; Reviewed; Region: thyA; PRK01827
574093001882	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
574093001883	dimerization interface [polypeptide binding]; other site
574093001884	active site
574093001885	Protein of unknown function (DUF3042); Region: DUF3042; pfam11240
574093001886	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
574093001887	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
574093001888	GTPases [General function prediction only]; Region: HflX; COG2262
574093001889	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
574093001890	HflX GTPase family; Region: HflX; cd01878
574093001891	G1 box; other site
574093001892	GTP/Mg2+ binding site [chemical binding]; other site
574093001893	Switch I region; other site
574093001894	G2 box; other site
574093001895	G3 box; other site
574093001896	Switch II region; other site
574093001897	G4 box; other site
574093001898	G5 box; other site
574093001899	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
574093001900	ribonuclease Z; Region: RNase_Z; TIGR02651
574093001901	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
574093001902	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
574093001903	NAD(P) binding site [chemical binding]; other site
574093001904	active site
574093001905	Transcriptional regulator [Transcription]; Region: LysR; COG0583
574093001906	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
574093001907	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
574093001908	dimerization interface [polypeptide binding]; other site
574093001909	Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014
574093001910	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
574093001911	active site residue [active]
574093001912	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
574093001913	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
574093001914	RNA binding surface [nucleotide binding]; other site
574093001915	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
574093001916	active site
574093001917	uracil binding [chemical binding]; other site
574093001918	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
574093001919	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
574093001920	G1 box; other site
574093001921	putative GEF interaction site [polypeptide binding]; other site
574093001922	GTP/Mg2+ binding site [chemical binding]; other site
574093001923	Switch I region; other site
574093001924	G2 box; other site
574093001925	G3 box; other site
574093001926	Switch II region; other site
574093001927	G4 box; other site
574093001928	G5 box; other site
574093001929	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
574093001930	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
574093001931	Protein of unknown function (DUF3165); Region: DUF3165; pfam11364
574093001932	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652
574093001933	Protein of unknown function (DUF1430); Region: DUF1430; pfam07242
574093001934	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
574093001935	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
574093001936	Walker A/P-loop; other site
574093001937	ATP binding site [chemical binding]; other site
574093001938	Q-loop/lid; other site
574093001939	ABC transporter signature motif; other site
574093001940	Walker B; other site
574093001941	D-loop; other site
574093001942	H-loop/switch region; other site
574093001943	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
574093001944	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
574093001945	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
574093001946	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
574093001947	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
574093001948	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
574093001949	homodimer interface [polypeptide binding]; other site
574093001950	active site
574093001951	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
574093001952	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
574093001953	Cell division protein FtsQ; Region: FtsQ; pfam03799
574093001954	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
574093001955	active site
574093001956	dimer interface [polypeptide binding]; other site
574093001957	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
574093001958	active site
574093001959	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
574093001960	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
574093001961	Walker A/P-loop; other site
574093001962	ATP binding site [chemical binding]; other site
574093001963	Q-loop/lid; other site
574093001964	ABC transporter signature motif; other site
574093001965	Walker B; other site
574093001966	D-loop; other site
574093001967	H-loop/switch region; other site
574093001968	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
574093001969	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
574093001970	substrate binding pocket [chemical binding]; other site
574093001971	membrane-bound complex binding site; other site
574093001972	hinge residues; other site
574093001973	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
574093001974	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
574093001975	Q-loop/lid; other site
574093001976	ABC transporter signature motif; other site
574093001977	Walker B; other site
574093001978	D-loop; other site
574093001979	H-loop/switch region; other site
574093001980	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
574093001981	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
574093001982	dimer interface [polypeptide binding]; other site
574093001983	conserved gate region; other site
574093001984	putative PBP binding loops; other site
574093001985	ABC-ATPase subunit interface; other site
574093001986	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
574093001987	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
574093001988	dimer interface [polypeptide binding]; other site
574093001989	conserved gate region; other site
574093001990	putative PBP binding loops; other site
574093001991	ABC-ATPase subunit interface; other site
574093001992	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
574093001993	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
574093001994	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
574093001995	dimer interface [polypeptide binding]; other site
574093001996	putative anticodon binding site; other site
574093001997	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
574093001998	motif 1; other site
574093001999	active site
574093002000	motif 2; other site
574093002001	motif 3; other site
574093002002	L-lactate oxidase; Region: L_lactate_ox; TIGR02708
574093002003	L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2.  This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737
574093002004	teramer interface [polypeptide binding]; other site
574093002005	active site
574093002006	FMN binding site [chemical binding]; other site
574093002007	catalytic residues [active]
574093002008	Putative transcription activator [Transcription]; Region: TenA; COG0819
574093002009	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
574093002010	substrate binding site [chemical binding]; other site
574093002011	multimerization interface [polypeptide binding]; other site
574093002012	ATP binding site [chemical binding]; other site
574093002013	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
574093002014	thiamine phosphate binding site [chemical binding]; other site
574093002015	active site
574093002016	pyrophosphate binding site [ion binding]; other site
574093002017	ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721
574093002018	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
574093002019	Walker A/P-loop; other site
574093002020	ATP binding site [chemical binding]; other site
574093002021	ABC transporter; Region: ABC_tran; pfam00005
574093002022	Q-loop/lid; other site
574093002023	ABC transporter signature motif; other site
574093002024	Walker B; other site
574093002025	D-loop; other site
574093002026	H-loop/switch region; other site
574093002027	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
574093002028	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
574093002029	Walker A/P-loop; other site
574093002030	ATP binding site [chemical binding]; other site
574093002031	Q-loop/lid; other site
574093002032	ABC transporter signature motif; other site
574093002033	Walker B; other site
574093002034	D-loop; other site
574093002035	H-loop/switch region; other site
574093002036	Putative transcription activator [Transcription]; Region: TenA; COG0819
574093002037	Predicted membrane protein [Function unknown]; Region: COG4732
574093002038	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
574093002039	substrate binding site [chemical binding]; other site
574093002040	multimerization interface [polypeptide binding]; other site
574093002041	ATP binding site [chemical binding]; other site
574093002042	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
574093002043	thiamine phosphate binding site [chemical binding]; other site
574093002044	active site
574093002045	pyrophosphate binding site [ion binding]; other site
574093002046	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
574093002047	dimer interface [polypeptide binding]; other site
574093002048	substrate binding site [chemical binding]; other site
574093002049	ATP binding site [chemical binding]; other site
574093002050	Predicted transcriptional regulator [Transcription]; Region: COG3682
574093002051	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
574093002052	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
574093002053	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
574093002054	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
574093002055	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
574093002056	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
574093002057	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
574093002058	pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720
574093002059	PYR/PP interface [polypeptide binding]; other site
574093002060	dimer interface [polypeptide binding]; other site
574093002061	tetramer interface [polypeptide binding]; other site
574093002062	TPP binding site [chemical binding]; other site
574093002063	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
574093002064	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
574093002065	TPP-binding site [chemical binding]; other site
574093002066	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
574093002067	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
574093002068	active site
574093002069	DDE superfamily endonuclease; Region: DDE_3; pfam13358
574093002070	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
574093002071	Winged helix-turn helix; Region: HTH_33; pfam13592
574093002072	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
574093002073	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
574093002074	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
574093002075	Sodium:neurotransmitter symporter family; Region: SNF; cl11976
574093002076	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
574093002077	Na2 binding site [ion binding]; other site
574093002078	putative substrate binding site 1 [chemical binding]; other site
574093002079	Na binding site 1 [ion binding]; other site
574093002080	putative substrate binding site 2 [chemical binding]; other site
574093002081	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
574093002082	Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106
574093002083	dimer interface [polypeptide binding]; other site
574093002084	TipAS antibiotic-recognition domain; Region: TipAS; pfam07739
574093002085	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
574093002086	putative active site [active]
574093002087	nucleotide binding site [chemical binding]; other site
574093002088	nudix motif; other site
574093002089	putative metal binding site [ion binding]; other site
574093002090	HI0933-like protein; Region: HI0933_like; pfam03486
574093002091	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307
574093002092	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
574093002093	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
574093002094	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
574093002095	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
574093002096	catalytic motif [active]
574093002097	Zn binding site [ion binding]; other site
574093002098	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
574093002099	active site
574093002100	Clp protease; Region: CLP_protease; pfam00574
574093002101	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
574093002102	oligomer interface [polypeptide binding]; other site
574093002103	active site residues [active]
574093002104	hypothetical protein; Provisional; Region: PRK02302
574093002105	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
574093002106	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
574093002107	putative ligand binding site [chemical binding]; other site
574093002108	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
574093002109	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
574093002110	TM-ABC transporter signature motif; other site
574093002111	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
574093002112	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
574093002113	TM-ABC transporter signature motif; other site
574093002114	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
574093002115	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
574093002116	Walker A/P-loop; other site
574093002117	ATP binding site [chemical binding]; other site
574093002118	Q-loop/lid; other site
574093002119	ABC transporter signature motif; other site
574093002120	Walker B; other site
574093002121	D-loop; other site
574093002122	H-loop/switch region; other site
574093002123	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
574093002124	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
574093002125	Walker A/P-loop; other site
574093002126	ATP binding site [chemical binding]; other site
574093002127	Q-loop/lid; other site
574093002128	ABC transporter signature motif; other site
574093002129	Walker B; other site
574093002130	D-loop; other site
574093002131	H-loop/switch region; other site
574093002132	FOG: CBS domain [General function prediction only]; Region: COG0517
574093002133	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc2; cd04585
574093002134	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116
574093002135	peptide chain release factor 2; Region: prfB; TIGR00020
574093002136	PCRF domain; Region: PCRF; pfam03462
574093002137	RF-1 domain; Region: RF-1; pfam00472
574093002138	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
574093002139	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
574093002140	Walker A/P-loop; other site
574093002141	ATP binding site [chemical binding]; other site
574093002142	Q-loop/lid; other site
574093002143	ABC transporter signature motif; other site
574093002144	Walker B; other site
574093002145	D-loop; other site
574093002146	H-loop/switch region; other site
574093002147	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
574093002148	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
574093002149	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
574093002150	PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003
574093002151	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
574093002152	active site turn [active]
574093002153	phosphorylation site [posttranslational modification]
574093002154	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
574093002155	HPr interaction site; other site
574093002156	glycerol kinase (GK) interaction site [polypeptide binding]; other site
574093002157	active site
574093002158	phosphorylation site [posttranslational modification]
574093002159	Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079
574093002160	putative catalytic site [active]
574093002161	putative metal binding site [ion binding]; other site
574093002162	putative phosphate binding site [ion binding]; other site
574093002163	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
574093002164	DEAD-like helicases superfamily; Region: DEXDc; smart00487
574093002165	ATP binding site [chemical binding]; other site
574093002166	Mg++ binding site [ion binding]; other site
574093002167	motif III; other site
574093002168	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
574093002169	nucleotide binding region [chemical binding]; other site
574093002170	ATP-binding site [chemical binding]; other site
574093002171	S-adenosylmethionine synthetase; Validated; Region: PRK05250
574093002172	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
574093002173	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
574093002174	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
574093002175	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
574093002176	Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741
574093002177	active site
574093002178	FMN binding site [chemical binding]; other site
574093002179	substrate binding site [chemical binding]; other site
574093002180	catalytic residues [active]
574093002181	homodimer interface [polypeptide binding]; other site
574093002182	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
574093002183	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
574093002184	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
574093002185	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
574093002186	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
574093002187	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470
574093002188	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455
574093002189	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
574093002190	FeS/SAM binding site; other site
574093002191	VanZ like family; Region: VanZ; pfam04892
574093002192	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
574093002193	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
574093002194	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
574093002195	ABC transporter; Region: ABC_tran_2; pfam12848
574093002196	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
574093002197	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
574093002198	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
574093002199	Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652
574093002200	active site
574093002201	D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634
574093002202	Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228
574093002203	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
574093002204	KH domain; Region: KH_4; pfam13083
574093002205	G-X-X-G motif; other site
574093002206	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
574093002207	potential frameshift: common BLAST hit: gi|298503218|ref|YP_003725158.1| 16S rRNA-processing protein
574093002208	RimM N-terminal domain; Region: RimM; pfam01782
574093002209	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
574093002210	RimM N-terminal domain; Region: RimM; pfam01782
574093002211	PRC-barrel domain; Region: PRC; pfam05239
574093002212	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
574093002213	ATP cone domain; Region: ATP-cone; pfam03477
574093002214	Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901
574093002215	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
574093002216	glutathione reductase; Validated; Region: PRK06116
574093002217	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
574093002218	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
574093002219	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
574093002220	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
574093002221	HlyD family secretion protein; Region: HlyD_3; pfam13437
574093002222	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
574093002223	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
574093002224	Walker A/P-loop; other site
574093002225	ATP binding site [chemical binding]; other site
574093002226	Q-loop/lid; other site
574093002227	ABC transporter signature motif; other site
574093002228	Walker B; other site
574093002229	D-loop; other site
574093002230	H-loop/switch region; other site
574093002231	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
574093002232	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
574093002233	FtsX-like permease family; Region: FtsX; pfam02687
574093002234	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
574093002235	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
574093002236	active site
574093002237	HIGH motif; other site
574093002238	KMSKS motif; other site
574093002239	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
574093002240	tRNA binding surface [nucleotide binding]; other site
574093002241	anticodon binding site; other site
574093002242	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
574093002243	dimer interface [polypeptide binding]; other site
574093002244	putative tRNA-binding site [nucleotide binding]; other site
574093002245	Predicted transcriptional regulators [Transcription]; Region: COG1695
574093002246	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
574093002247	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
574093002248	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
574093002249	active site
574093002250	catalytic tetrad [active]
574093002251	Protein of unknown function (DUF2829); Region: DUF2829; pfam11195
574093002252	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550
574093002253	classical (c) SDRs; Region: SDR_c; cd05233
574093002254	NAD(P) binding site [chemical binding]; other site
574093002255	active site
574093002256	Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684
574093002257	nudix motif; other site
574093002258	Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574
574093002259	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
574093002260	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
574093002261	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
574093002262	Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601
574093002263	Zn binding site [ion binding]; other site
574093002264	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
574093002265	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
574093002266	active site
574093002267	phosphorylation site [posttranslational modification]
574093002268	intermolecular recognition site; other site
574093002269	dimerization interface [polypeptide binding]; other site
574093002270	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
574093002271	DNA binding site [nucleotide binding]
574093002272	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
574093002273	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
574093002274	dimer interface [polypeptide binding]; other site
574093002275	phosphorylation site [posttranslational modification]
574093002276	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
574093002277	ATP binding site [chemical binding]; other site
574093002278	Mg2+ binding site [ion binding]; other site
574093002279	G-X-G motif; other site
574093002280	Protein of unknown function (DUF3270); Region: DUF3270; pfam11674
574093002281	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
574093002282	Peptidase family U32; Region: Peptidase_U32; pfam01136
574093002283	bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK07246
574093002284	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
574093002285	active site
574093002286	catalytic site [active]
574093002287	substrate binding site [chemical binding]; other site
574093002288	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
574093002289	ATP binding site [chemical binding]; other site
574093002290	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
574093002291	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
574093002292	DJ-1 family protein; Region: not_thiJ; TIGR01383
574093002293	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
574093002294	conserved cys residue [active]
574093002295	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
574093002296	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
574093002297	motif II; other site
574093002298	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
574093002299	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
574093002300	Mg2+ binding site [ion binding]; other site
574093002301	G-X-G motif; other site
574093002302	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
574093002303	anchoring element; other site
574093002304	dimer interface [polypeptide binding]; other site
574093002305	ATP binding site [chemical binding]; other site
574093002306	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
574093002307	active site
574093002308	putative metal-binding site [ion binding]; other site
574093002309	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
574093002310	Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477
574093002311	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
574093002312	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
574093002313	Domain of unknown function (DUF1827); Region: DUF1827; pfam08860
574093002314	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
574093002315	Transposase; Region: HTH_Tnp_IS630; pfam01710
574093002316	Helix-turn-helix domain; Region: HTH_28; pfam13518
574093002317	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
574093002318	DDE superfamily endonuclease; Region: DDE_3; pfam13358
574093002319	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
574093002320	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
574093002321	Walker A motif; other site
574093002322	ATP binding site [chemical binding]; other site
574093002323	Walker B motif; other site
574093002324	arginine finger; other site
574093002325	UvrB/uvrC motif; Region: UVR; pfam02151
574093002326	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
574093002327	Walker A motif; other site
574093002328	ATP binding site [chemical binding]; other site
574093002329	Walker B motif; other site
574093002330	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
574093002331	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703
574093002332	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
574093002333	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
574093002334	dimer interface [polypeptide binding]; other site
574093002335	conserved gate region; other site
574093002336	putative PBP binding loops; other site
574093002337	ABC-ATPase subunit interface; other site
574093002338	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
574093002339	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
574093002340	Walker A/P-loop; other site
574093002341	ATP binding site [chemical binding]; other site
574093002342	Q-loop/lid; other site
574093002343	ABC transporter signature motif; other site
574093002344	Walker B; other site
574093002345	D-loop; other site
574093002346	H-loop/switch region; other site
574093002347	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179
574093002348	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
574093002349	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
574093002350	homodimer interface [polypeptide binding]; other site
574093002351	NADP binding site [chemical binding]; other site
574093002352	substrate binding site [chemical binding]; other site
574093002353	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
574093002354	putative substrate binding site [chemical binding]; other site
574093002355	putative ATP binding site [chemical binding]; other site
574093002356	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
574093002357	tetramer (dimer of dimers) interface [polypeptide binding]; other site
574093002358	active site
574093002359	dimer interface [polypeptide binding]; other site
574093002360	phosphopentomutase; Provisional; Region: PRK05362
574093002361	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
574093002362	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797
574093002363	purine nucleoside phosphorylase; Provisional; Region: PRK08202
574093002364	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741
574093002365	nucleophilic elbow; other site
574093002366	catalytic triad; other site
574093002367	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
574093002368	Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289
574093002369	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
574093002370	topology modulation protein; Provisional; Region: PRK07261
574093002371	AAA domain; Region: AAA_17; pfam13207
574093002372	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
574093002373	pantothenate kinase; Provisional; Region: PRK05439
574093002374	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
574093002375	ATP-binding site [chemical binding]; other site
574093002376	CoA-binding site [chemical binding]; other site
574093002377	Mg2+-binding site [ion binding]; other site
574093002378	Methyltransferase domain; Region: Methyltransf_31; pfam13847
574093002379	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
574093002380	S-adenosylmethionine binding site [chemical binding]; other site
574093002381	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
574093002382	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
574093002383	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
574093002384	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
574093002385	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
574093002386	intersubunit interface [polypeptide binding]; other site
574093002387	active site
574093002388	catalytic residue [active]
574093002389	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
574093002390	active site
574093002391	catalytic motif [active]
574093002392	Zn binding site [ion binding]; other site
574093002393	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
574093002394	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
574093002395	ligand binding site [chemical binding]; other site
574093002396	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
574093002397	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
574093002398	Walker A/P-loop; other site
574093002399	ATP binding site [chemical binding]; other site
574093002400	Q-loop/lid; other site
574093002401	ABC transporter signature motif; other site
574093002402	Walker B; other site
574093002403	D-loop; other site
574093002404	H-loop/switch region; other site
574093002405	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
574093002406	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
574093002407	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
574093002408	TM-ABC transporter signature motif; other site
574093002409	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
574093002410	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
574093002411	TM-ABC transporter signature motif; other site
574093002412	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
574093002413	Helix-turn-helix domain; Region: HTH_28; pfam13518
574093002414	putative transposase OrfB; Reviewed; Region: PHA02517
574093002415	HTH-like domain; Region: HTH_21; pfam13276
574093002416	Integrase core domain; Region: rve; pfam00665
574093002417	Integrase core domain; Region: rve_2; pfam13333
574093002418	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
574093002419	DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058
574093002420	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
574093002421	Mg2+ binding site [ion binding]; other site
574093002422	G-X-G motif; other site
574093002423	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
574093002424	anchoring element; other site
574093002425	dimer interface [polypeptide binding]; other site
574093002426	ATP binding site [chemical binding]; other site
574093002427	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
574093002428	active site
574093002429	putative metal-binding site [ion binding]; other site
574093002430	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
574093002431	DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061
574093002432	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
574093002433	CAP-like domain; other site
574093002434	active site
574093002435	primary dimer interface [polypeptide binding]; other site
574093002436	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
574093002437	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
574093002438	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
574093002439	homodimer interface [polypeptide binding]; other site
574093002440	substrate-cofactor binding pocket; other site
574093002441	catalytic residue [active]
574093002442	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
574093002443	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
574093002444	Predicted membrane protein [Function unknown]; Region: COG3819
574093002445	Predicted membrane protein [Function unknown]; Region: COG3817
574093002446	Protein of unknown function (DUF979); Region: DUF979; pfam06166
574093002447	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
574093002448	putative substrate binding pocket [chemical binding]; other site
574093002449	AC domain interface; other site
574093002450	catalytic triad [active]
574093002451	AB domain interface; other site
574093002452	interchain disulfide; other site
574093002453	Protein of unknown function (DUF2969); Region: DUF2969; pfam11184
574093002454	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
574093002455	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
574093002456	RNA binding site [nucleotide binding]; other site
574093002457	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
574093002458	RNA binding site [nucleotide binding]; other site
574093002459	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
574093002460	RNA binding site [nucleotide binding]; other site
574093002461	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
574093002462	RNA binding site [nucleotide binding]; other site
574093002463	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
574093002464	Transposase; Region: DDE_Tnp_ISL3; pfam01610
574093002465	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
574093002466	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
574093002467	GAF domain; Region: GAF_2; pfam13185
574093002468	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
574093002469	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
574093002470	Walker A motif; other site
574093002471	ATP binding site [chemical binding]; other site
574093002472	Walker B motif; other site
574093002473	arginine finger; other site
574093002474	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
574093002475	Protein of unknown function (DUF3272); Region: DUF3272; pfam11676
574093002476	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
574093002477	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
574093002478	Walker A/P-loop; other site
574093002479	ATP binding site [chemical binding]; other site
574093002480	Q-loop/lid; other site
574093002481	ABC transporter signature motif; other site
574093002482	Walker B; other site
574093002483	D-loop; other site
574093002484	H-loop/switch region; other site
574093002485	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
574093002486	FeS assembly protein SufD; Region: sufD; TIGR01981
574093002487	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
574093002488	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
574093002489	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
574093002490	catalytic residue [active]
574093002491	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
574093002492	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
574093002493	trimerization site [polypeptide binding]; other site
574093002494	active site
574093002495	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
574093002496	FeS assembly protein SufB; Region: sufB; TIGR01980
574093002497	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
574093002498	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
574093002499	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
574093002500	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
574093002501	Domain of unknown function DUF20; Region: UPF0118; pfam01594
574093002502	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
574093002503	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
574093002504	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
574093002505	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
574093002506	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
574093002507	putative substrate binding site [chemical binding]; other site
574093002508	putative ATP binding site [chemical binding]; other site
574093002509	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
574093002510	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
574093002511	active site
574093002512	phosphorylation site [posttranslational modification]
574093002513	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
574093002514	active site
574093002515	P-loop; other site
574093002516	phosphorylation site [posttranslational modification]
574093002517	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
574093002518	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
574093002519	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
574093002520	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
574093002521	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
574093002522	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
574093002523	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
574093002524	Walker A/P-loop; other site
574093002525	ATP binding site [chemical binding]; other site
574093002526	Q-loop/lid; other site
574093002527	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
574093002528	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
574093002529	DDE superfamily endonuclease; Region: DDE_4; cl17710
574093002530	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
574093002531	ABC transporter signature motif; other site
574093002532	Walker B; other site
574093002533	D-loop; other site
574093002534	H-loop/switch region; other site
574093002535	FtsX-like permease family; Region: FtsX; pfam02687
574093002536	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
574093002537	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
574093002538	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
574093002539	catalytic residue [active]
574093002540	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
574093002541	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
574093002542	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
574093002543	Ligand Binding Site [chemical binding]; other site
574093002544	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
574093002545	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947
574093002546	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947
574093002547	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
574093002548	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
574093002549	HsdM N-terminal domain; Region: HsdM_N; pfam12161
574093002550	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
574093002551	hypothetical protein; Validated; Region: PRK08116
574093002552	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
574093002553	Walker A motif; other site
574093002554	ATP binding site [chemical binding]; other site
574093002555	Walker B motif; other site
574093002556	arginine finger; other site
574093002557	Protein of unknown function (DUF3801); Region: DUF3801; pfam12687
574093002558	Prophage antirepressor [Transcription]; Region: COG3617
574093002559	BRO family, N-terminal domain; Region: Bro-N; smart01040
574093002560	Phage antirepressor protein KilAC domain; Region: ANT; pfam03374
574093002561	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
574093002562	TraM recognition site of TraD and TraG; Region: TraG-D_C; pfam12696
574093002563	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
574093002564	non-specific DNA binding site [nucleotide binding]; other site
574093002565	salt bridge; other site
574093002566	sequence-specific DNA binding site [nucleotide binding]; other site
574093002567	similar to type IV secretory pathway protein VirD4
574093002568	Protein of unknown function (DUF1706); Region: DUF1706; pfam08020
574093002569	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643
574093002570	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
574093002571	generic binding surface II; other site
574093002572	generic binding surface I; other site
574093002573	Maff2 family; Region: Maff2; pfam12750
574093002574	PrgI family protein; Region: PrgI; pfam12666
574093002575	AAA-like domain; Region: AAA_10; pfam12846
574093002576	Domain of unknown function DUF87; Region: DUF87; pfam01935
574093002577	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
574093002578	NlpC/P60 family; Region: NLPC_P60; pfam00877
574093002579	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
574093002580	Domain of unknown function (DUF4366); Region: DUF4366; pfam14283
574093002581	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
574093002582	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
574093002583	DNA topoisomerase III; Provisional; Region: PRK07726
574093002584	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
574093002585	active site
574093002586	putative interdomain interaction site [polypeptide binding]; other site
574093002587	putative metal-binding site [ion binding]; other site
574093002588	putative nucleotide binding site [chemical binding]; other site
574093002589	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
574093002590	domain I; other site
574093002591	DNA binding groove [nucleotide binding]
574093002592	phosphate binding site [ion binding]; other site
574093002593	domain II; other site
574093002594	domain III; other site
574093002595	nucleotide binding site [chemical binding]; other site
574093002596	catalytic site [active]
574093002597	domain IV; other site
574093002598	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
574093002599	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
574093002600	cofactor binding site; other site
574093002601	DNA binding site [nucleotide binding]
574093002602	substrate interaction site [chemical binding]; other site
574093002603	Methyltransferase domain; Region: Methyltransf_26; pfam13659
574093002604	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
574093002605	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
574093002606	DEAD-like helicases superfamily; Region: DEXDc; smart00487
574093002607	DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646
574093002608	helicase superfamily c-terminal domain; Region: HELICc; smart00490
574093002609	nucleotide binding region [chemical binding]; other site
574093002610	ATP-binding site [chemical binding]; other site
574093002611	N-terminal domain of reverse transcriptase; Region: RVT_N; pfam13655
574093002612	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
574093002613	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
574093002614	putative active site [active]
574093002615	putative NTP binding site [chemical binding]; other site
574093002616	putative nucleic acid binding site [nucleotide binding]; other site
574093002617	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
574093002618	similar to 3' end of superfamily II DNA and RNA helicase; disrupted by retron-type reverse transcriptase; similar to MGAS10750_Spy1698
574093002619	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
574093002620	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
574093002621	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
574093002622	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
574093002623	Walker A/P-loop; other site
574093002624	ATP binding site [chemical binding]; other site
574093002625	Q-loop/lid; other site
574093002626	ABC transporter signature motif; other site
574093002627	Walker B; other site
574093002628	D-loop; other site
574093002629	H-loop/switch region; other site
574093002630	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
574093002631	Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559
574093002632	Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398
574093002633	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
574093002634	S-adenosylmethionine binding site [chemical binding]; other site
574093002635	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
574093002636	similar to cytidine deaminase
574093002637	similar to DNA recombinase
574093002638	potential frameshift: common BLAST hit: gi|257066848|ref|YP_003153104.1| transposase IS116/IS110/IS902 family protein
574093002639	Transposase; Region: DEDD_Tnp_IS110; pfam01548
574093002640	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
574093002641	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
574093002642	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
574093002643	Cation transporter family protein; Region: LIC; TIGR00860
574093002644	Domain of unknown function (DUF955); Region: DUF955; pfam06114
574093002645	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
574093002646	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
574093002647	non-specific DNA binding site [nucleotide binding]; other site
574093002648	salt bridge; other site
574093002649	sequence-specific DNA binding site [nucleotide binding]; other site
574093002650	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
574093002651	Sigma-70, region 4; Region: Sigma70_r4; pfam04545
574093002652	DNA binding residues [nucleotide binding]
574093002653	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
574093002654	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
574093002655	catalytic residues [active]
574093002656	catalytic nucleophile [active]
574093002657	Recombinase; Region: Recombinase; pfam07508
574093002658	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
574093002659	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
574093002660	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
574093002661	catalytic residues [active]
574093002662	catalytic nucleophile [active]
574093002663	Recombinase; Region: Recombinase; pfam07508
574093002664	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
574093002665	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
574093002666	catalytic residues [active]
574093002667	catalytic nucleophile [active]
574093002668	Recombinase; Region: Recombinase; pfam07508
574093002669	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
574093002670	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
574093002671	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
574093002672	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
574093002673	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
574093002674	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
574093002675	Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654
574093002676	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
574093002677	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
574093002678	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
574093002679	active site
574093002680	catalytic residues [active]
574093002681	DNA binding site [nucleotide binding]
574093002682	Int/Topo IB signature motif; other site
574093002683	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
574093002684	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
574093002685	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
574093002686	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
574093002687	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
574093002688	ATP binding site [chemical binding]; other site
574093002689	putative Mg++ binding site [ion binding]; other site
574093002690	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
574093002691	Arginine repressor [Transcription]; Region: ArgR; COG1438
574093002692	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
574093002693	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
574093002694	x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371
574093002695	X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; pfam09168
574093002696	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
574093002697	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279
574093002698	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
574093002699	active site
574093002700	PHP Thumb interface [polypeptide binding]; other site
574093002701	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
574093002702	generic binding surface II; other site
574093002703	generic binding surface I; other site
574093002704	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
574093002705	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
574093002706	active site
574093002707	ADP/pyrophosphate binding site [chemical binding]; other site
574093002708	dimerization interface [polypeptide binding]; other site
574093002709	allosteric effector site; other site
574093002710	fructose-1,6-bisphosphate binding site; other site
574093002711	pyruvate kinase; Provisional; Region: PRK05826
574093002712	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
574093002713	domain interfaces; other site
574093002714	active site
574093002715	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
574093002716	Domain of unknown function (DUF4300); Region: DUF4300; pfam14133
574093002717	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
574093002718	Predicted membrane protein [Function unknown]; Region: COG3689
574093002719	Predicted permeases [General function prediction only]; Region: COG0701
574093002720	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
574093002721	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
574093002722	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
574093002723	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
574093002724	RNA binding site [nucleotide binding]; other site
574093002725	SprT homologues; Region: SprT; cl01182
574093002726	hypothetical protein; Provisional; Region: PRK04351
574093002727	Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983
574093002728	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
574093002729	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
574093002730	Walker A/P-loop; other site
574093002731	ATP binding site [chemical binding]; other site
574093002732	Q-loop/lid; other site
574093002733	ABC transporter signature motif; other site
574093002734	Walker B; other site
574093002735	D-loop; other site
574093002736	H-loop/switch region; other site
574093002737	FtsX-like permease family; Region: FtsX; pfam02687
574093002738	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
574093002739	Integrase core domain; Region: rve; pfam00665
574093002740	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
574093002741	Helix-turn-helix domain; Region: HTH_38; pfam13936
574093002742	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
574093002743	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
574093002744	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
574093002745	homodimer interface [polypeptide binding]; other site
574093002746	pyridoxal 5'-phosphate binding site [chemical binding]; other site
574093002747	catalytic residue [active]
574093002748	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
574093002749	Transposase; Region: DEDD_Tnp_IS110; pfam01548
574093002750	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
574093002751	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
574093002752	Transposase; Region: DEDD_Tnp_IS110; pfam01548
574093002753	spermidine synthase; Provisional; Region: PRK00811
574093002754	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
574093002755	S-adenosylmethionine binding site [chemical binding]; other site
574093002756	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
574093002757	Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; pfam01488
574093002758	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
574093002759	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
574093002760	dimer interface [polypeptide binding]; other site
574093002761	active site
574093002762	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
574093002763	catalytic residues [active]
574093002764	substrate binding site [chemical binding]; other site
574093002765	agmatine deiminase; Provisional; Region: PRK13551
574093002766	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
574093002767	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
574093002768	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
574093002769	putative active site; other site
574093002770	catalytic triad [active]
574093002771	putative dimer interface [polypeptide binding]; other site
574093002772	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
574093002773	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
574093002774	active site
574093002775	motif I; other site
574093002776	motif II; other site
574093002777	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
574093002778	CAAX protease self-immunity; Region: Abi; pfam02517
574093002779	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
574093002780	Transcriptional regulator [Transcription]; Region: LysR; COG0583
574093002781	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
574093002782	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
574093002783	dimerization interface [polypeptide binding]; other site
574093002784	lipoprotein signal peptidase; Provisional; Region: PRK14797
574093002785	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
574093002786	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
574093002787	RNA binding surface [nucleotide binding]; other site
574093002788	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
574093002789	active site
574093002790	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
574093002791	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
574093002792	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
574093002793	Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263
574093002794	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
574093002795	nucleotide binding site [chemical binding]; other site
574093002796	homotetrameric interface [polypeptide binding]; other site
574093002797	putative phosphate binding site [ion binding]; other site
574093002798	putative allosteric binding site; other site
574093002799	PUA domain; Region: PUA; pfam01472
574093002800	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
574093002801	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
574093002802	putative catalytic cysteine [active]
574093002803	pyrroline-5-carboxylate reductase; Region: PLN02688
574093002804	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
574093002805	thymidylate kinase; Validated; Region: tmk; PRK00698
574093002806	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
574093002807	TMP-binding site; other site
574093002808	ATP-binding site [chemical binding]; other site
574093002809	DNA polymerase III subunit delta'; Validated; Region: PRK07276
574093002810	DNA polymerase III subunit delta'; Validated; Region: PRK08485
574093002811	DNA replication intiation control protein YabA; Reviewed; Region: PRK13169
574093002812	Predicted methyltransferases [General function prediction only]; Region: COG0313
574093002813	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
574093002814	putative SAM binding site [chemical binding]; other site
574093002815	putative homodimer interface [polypeptide binding]; other site
574093002816	Uncharacterized conserved protein [Function unknown]; Region: COG4283
574093002817	potential frameshift: common BLAST hit: gi|225858737|ref|YP_002740247.1| phage protein
574093002818	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
574093002819	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
574093002820	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
574093002821	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
574093002822	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
574093002823	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
574093002824	Glucose inhibited division protein A; Region: GIDA; pfam01134
574093002825	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
574093002826	putative nucleotide binding site [chemical binding]; other site
574093002827	uridine monophosphate binding site [chemical binding]; other site
574093002828	homohexameric interface [polypeptide binding]; other site
574093002829	ribosome recycling factor; Reviewed; Region: frr; PRK00083
574093002830	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
574093002831	hinge region; other site
574093002832	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
574093002833	S1 domain; Region: S1_2; pfam13509
574093002834	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
574093002835	hypothetical protein; Provisional; Region: PRK13672
574093002836	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
574093002837	PhoH-like protein; Region: PhoH; pfam02562
574093002838	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
574093002839	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
574093002840	Coenzyme A binding pocket [chemical binding]; other site
574093002841	Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070
574093002842	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
574093002843	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
574093002844	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
574093002845	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
574093002846	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
574093002847	SLBB domain; Region: SLBB; pfam10531
574093002848	comEA protein; Region: comE; TIGR01259
574093002849	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
574093002850	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
574093002851	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
574093002852	Competence protein; Region: Competence; pfam03772
574093002853	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
574093002854	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
574093002855	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
574093002856	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
574093002857	Walker A/P-loop; other site
574093002858	ATP binding site [chemical binding]; other site
574093002859	Q-loop/lid; other site
574093002860	ABC transporter signature motif; other site
574093002861	Walker B; other site
574093002862	D-loop; other site
574093002863	H-loop/switch region; other site
574093002864	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
574093002865	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
574093002866	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
574093002867	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
574093002868	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
574093002869	23S rRNA binding site [nucleotide binding]; other site
574093002870	L21 binding site [polypeptide binding]; other site
574093002871	L13 binding site [polypeptide binding]; other site
574093002872	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
574093002873	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
574093002874	dimer interface [polypeptide binding]; other site
574093002875	active site
574093002876	metal binding site [ion binding]; metal-binding site
574093002877	glutathione binding site [chemical binding]; other site
574093002878	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
574093002879	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
574093002880	FAD binding pocket [chemical binding]; other site
574093002881	FAD binding motif [chemical binding]; other site
574093002882	phosphate binding motif [ion binding]; other site
574093002883	beta-alpha-beta structure motif; other site
574093002884	NAD binding pocket [chemical binding]; other site
574093002885	Iron coordination center [ion binding]; other site
574093002886	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
574093002887	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
574093002888	heterodimer interface [polypeptide binding]; other site
574093002889	active site
574093002890	FMN binding site [chemical binding]; other site
574093002891	homodimer interface [polypeptide binding]; other site
574093002892	substrate binding site [chemical binding]; other site
574093002893	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
574093002894	Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193
574093002895	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
574093002896	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
574093002897	Domain of unknown function (DUF814); Region: DUF814; pfam05670
574093002898	metal-binding heat shock protein; Provisional; Region: PRK00016
574093002899	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
574093002900	GTPase Era; Reviewed; Region: era; PRK00089
574093002901	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
574093002902	G1 box; other site
574093002903	GTP/Mg2+ binding site [chemical binding]; other site
574093002904	Switch I region; other site
574093002905	G2 box; other site
574093002906	Switch II region; other site
574093002907	G3 box; other site
574093002908	G4 box; other site
574093002909	G5 box; other site
574093002910	KH domain; Region: KH_2; pfam07650
574093002911	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
574093002912	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
574093002913	DNA binding site [nucleotide binding]
574093002914	catalytic residue [active]
574093002915	H2TH interface [polypeptide binding]; other site
574093002916	putative catalytic residues [active]
574093002917	turnover-facilitating residue; other site
574093002918	intercalation triad [nucleotide binding]; other site
574093002919	8OG recognition residue [nucleotide binding]; other site
574093002920	putative reading head residues; other site
574093002921	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
574093002922	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
574093002923	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
574093002924	dephospho-CoA kinase; Region: TIGR00152
574093002925	CoA-binding site [chemical binding]; other site
574093002926	ATP-binding [chemical binding]; other site
574093002927	drug efflux system protein MdtG; Provisional; Region: PRK09874
574093002928	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
574093002929	putative substrate translocation pore; other site
574093002930	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
574093002931	Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314
574093002932	ribonuclease R; Region: RNase_R; TIGR02063
574093002933	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
574093002934	RNB domain; Region: RNB; pfam00773
574093002935	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
574093002936	RNA binding site [nucleotide binding]; other site
574093002937	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
574093002938	SmpB-tmRNA interface; other site
574093002939	tellurite resistance protein TehB; Provisional; Region: PRK12335
574093002940	Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615
574093002941	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
574093002942	S-adenosylmethionine binding site [chemical binding]; other site
574093002943	Competence protein CoiA-like family, contains a predicted nuclease    domain [General function prediction only]; Region: CoiA; COG4469
574093002944	Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164
574093002945	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
574093002946	active site
574093002947	Zn binding site [ion binding]; other site
574093002948	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
574093002949	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
574093002950	S-adenosylmethionine binding site [chemical binding]; other site
574093002951	potential frameshift: common BLAST hit: gi|225861132|ref|YP_002742641.1| foldase protein PrsA
574093002952	foldase protein PrsA; Reviewed; Region: prsA; PRK01326
574093002953	potential frameshift: common BLAST hit: gi|225858774|ref|YP_002740284.1| foldase protein PrsA
574093002954	foldase protein PrsA; Reviewed; Region: prsA; PRK01326
574093002955	foldase protein PrsA; Reviewed; Region: prsA; PRK01326
574093002956	Integrase core domain; Region: rve; pfam00665
574093002957	Integrase core domain; Region: rve_2; pfam13333
574093002958	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
574093002959	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
574093002960	catalytic core [active]
574093002961	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
574093002962	putative deacylase active site [active]
574093002963	Predicted membrane protein [Function unknown]; Region: COG2035
574093002964	Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757
574093002965	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
574093002966	active site
574093002967	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
574093002968	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
574093002969	Substrate binding site; other site
574093002970	Mg++ binding site; other site
574093002971	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
574093002972	active site
574093002973	substrate binding site [chemical binding]; other site
574093002974	CoA binding site [chemical binding]; other site
574093002975	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
574093002976	dimer interface [polypeptide binding]; other site
574093002977	ADP-ribose binding site [chemical binding]; other site
574093002978	active site
574093002979	nudix motif; other site
574093002980	metal binding site [ion binding]; metal-binding site
574093002981	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
574093002982	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
574093002983	MarR family; Region: MarR_2; cl17246
574093002984	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
574093002985	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
574093002986	active site
574093002987	catalytic site [active]
574093002988	substrate binding site [chemical binding]; other site
574093002989	Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781
574093002990	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
574093002991	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
574093002992	putative active site [active]
574093002993	catalytic site [active]
574093002994	putative metal binding site [ion binding]; other site
574093002995	Transposase; Region: HTH_Tnp_IS630; pfam01710
574093002996	Helix-turn-helix domain; Region: HTH_28; pfam13518
574093002997	Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases; Region: TM_EGFR-like; cl17045
574093002998	dimer interface [polypeptide binding]; other site
574093002999	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
574093003000	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
574093003001	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
574093003002	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
574093003003	catalytic residues [active]
574093003004	amino acid transporter; Region: 2A0306; TIGR00909
574093003005	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
574093003006	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
574093003007	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
574093003008	metal binding site [ion binding]; metal-binding site
574093003009	streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363
574093003010	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
574093003011	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
574093003012	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
574093003013	phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484
574093003014	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
574093003015	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
574093003016	motif II; other site
574093003017	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
574093003018	ligand binding site [chemical binding]; other site
574093003019	active site
574093003020	UGI interface [polypeptide binding]; other site
574093003021	catalytic site [active]
574093003022	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
574093003023	putative active site [active]
574093003024	nucleotide binding site [chemical binding]; other site
574093003025	nudix motif; other site
574093003026	putative metal binding site [ion binding]; other site
574093003027	dihydroorotase; Validated; Region: pyrC; PRK09357
574093003028	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
574093003029	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
574093003030	active site
574093003031	multidrug efflux protein; Reviewed; Region: PRK01766
574093003032	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
574093003033	cation binding site [ion binding]; other site
574093003034	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
574093003035	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
574093003036	tetramer interface [polypeptide binding]; other site
574093003037	TPP-binding site [chemical binding]; other site
574093003038	heterodimer interface [polypeptide binding]; other site
574093003039	phosphorylation loop region [posttranslational modification]
574093003040	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
574093003041	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
574093003042	alpha subunit interface [polypeptide binding]; other site
574093003043	TPP binding site [chemical binding]; other site
574093003044	heterodimer interface [polypeptide binding]; other site
574093003045	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
574093003046	dihydrolipoamide acetyltransferase; Provisional; Region: PRK14843
574093003047	e3 binding domain; Region: E3_binding; pfam02817
574093003048	e3 binding domain; Region: E3_binding; pfam02817
574093003049	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
574093003050	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
574093003051	E3 interaction surface; other site
574093003052	lipoyl attachment site [posttranslational modification]; other site
574093003053	dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350
574093003054	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
574093003055	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
574093003056	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
574093003057	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
574093003058	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
574093003059	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
574093003060	site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084
574093003061	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
574093003062	active site
574093003063	DNA binding site [nucleotide binding]
574093003064	Int/Topo IB signature motif; other site
574093003065	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
574093003066	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
574093003067	Cl- selectivity filter; other site
574093003068	Cl- binding residues [ion binding]; other site
574093003069	pore gating glutamate residue; other site
574093003070	dimer interface [polypeptide binding]; other site
574093003071	H+/Cl- coupling transport residue; other site
574093003072	TrkA-C domain; Region: TrkA_C; pfam02080
574093003073	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
574093003074	RNA/DNA hybrid binding site [nucleotide binding]; other site
574093003075	active site
574093003076	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
574093003077	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
574093003078	GTP/Mg2+ binding site [chemical binding]; other site
574093003079	G4 box; other site
574093003080	G5 box; other site
574093003081	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
574093003082	G1 box; other site
574093003083	G1 box; other site
574093003084	GTP/Mg2+ binding site [chemical binding]; other site
574093003085	Switch I region; other site
574093003086	G2 box; other site
574093003087	G2 box; other site
574093003088	G3 box; other site
574093003089	G3 box; other site
574093003090	Switch II region; other site
574093003091	Switch II region; other site
574093003092	G5 box; other site
574093003093	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
574093003094	G5 domain; Region: G5; pfam07501
574093003095	M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342
574093003096	The GLUG motif; Region: Glug; pfam07581
574093003097	M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580
574093003098	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
574093003099	Part of AAA domain; Region: AAA_19; pfam13245
574093003100	Family description; Region: UvrD_C_2; pfam13538
574093003101	Family description; Region: UvrD_C_2; pfam13538
574093003102	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
574093003103	ATP-dependent nuclease subunit B; Region: rexB_recomb; TIGR02774
574093003104	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
574093003105	Helix-turn-helix domain; Region: HTH_28; pfam13518
574093003106	Winged helix-turn helix; Region: HTH_29; pfam13551
574093003107	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
574093003108	DDE superfamily endonuclease; Region: DDE_3; pfam13358
574093003109	enolase; Provisional; Region: eno; PRK00077
574093003110	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
574093003111	dimer interface [polypeptide binding]; other site
574093003112	metal binding site [ion binding]; metal-binding site
574093003113	substrate binding pocket [chemical binding]; other site
574093003114	Uncharacterized conserved protein [Function unknown]; Region: COG5506
574093003115	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
574093003116	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
574093003117	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
574093003118	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
574093003119	glycogen synthase; Provisional; Region: glgA; PRK00654
574093003120	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
574093003121	ADP-binding pocket [chemical binding]; other site
574093003122	homodimer interface [polypeptide binding]; other site
574093003123	glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092
574093003124	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
574093003125	active site
574093003126	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
574093003127	dimer interface [polypeptide binding]; other site
574093003128	N-terminal domain interface [polypeptide binding]; other site
574093003129	sulfate 1 binding site; other site
574093003130	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
574093003131	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
574093003132	ligand binding site; other site
574093003133	oligomer interface; other site
574093003134	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
574093003135	dimer interface [polypeptide binding]; other site
574093003136	N-terminal domain interface [polypeptide binding]; other site
574093003137	sulfate 1 binding site; other site
574093003138	glycogen branching enzyme; Provisional; Region: PRK12313
574093003139	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
574093003140	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
574093003141	active site
574093003142	catalytic site [active]
574093003143	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
574093003144	NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082
574093003145	NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412
574093003146	tetrameric interface [polypeptide binding]; other site
574093003147	activator binding site; other site
574093003148	NADP binding site [chemical binding]; other site
574093003149	substrate binding site [chemical binding]; other site
574093003150	catalytic residues [active]
574093003151	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cl04227
574093003152	pullulanase, type I; Region: pulA_typeI; TIGR02104
574093003153	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
574093003154	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
574093003155	Ca binding site [ion binding]; other site
574093003156	active site
574093003157	catalytic site [active]
574093003158	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
574093003159	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
574093003160	nucleotide binding pocket [chemical binding]; other site
574093003161	K-X-D-G motif; other site
574093003162	catalytic site [active]
574093003163	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
574093003164	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
574093003165	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
574093003166	Dimer interface [polypeptide binding]; other site
574093003167	BRCT sequence motif; other site
574093003168	H+ Antiporter protein; Region: 2A0121; TIGR00900
574093003169	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
574093003170	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
574093003171	non-specific DNA binding site [nucleotide binding]; other site
574093003172	salt bridge; other site
574093003173	sequence-specific DNA binding site [nucleotide binding]; other site
574093003174	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
574093003175	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
574093003176	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
574093003177	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
574093003178	ABC transporter; Region: ABC_tran_2; pfam12848
574093003179	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
574093003180	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
574093003181	IHF dimer interface [polypeptide binding]; other site
574093003182	IHF - DNA interface [nucleotide binding]; other site
574093003183	EDD domain protein, DegV family; Region: DegV; TIGR00762
574093003184	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
574093003185	Uncharacterized conserved protein [Function unknown]; Region: COG1284
574093003186	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
574093003187	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
574093003188	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
574093003189	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
574093003190	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
574093003191	active site
574093003192	Riboflavin kinase; Region: Flavokinase; smart00904
574093003193	Domain of unknown function (DUF1980); Region: DUF1980; cl01492
574093003194	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
574093003195	Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868
574093003196	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
574093003197	Predicted membrane protein [Function unknown]; Region: COG3619
574093003198	hypothetical protein; Validated; Region: PRK00153
574093003199	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
574093003200	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
574093003201	Transposase; Region: DDE_Tnp_ISL3; pfam01610
574093003202	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
574093003203	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
574093003204	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
574093003205	RNA binding surface [nucleotide binding]; other site
574093003206	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
574093003207	active site
574093003208	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
574093003209	ATP-NAD kinase; Region: NAD_kinase; pfam01513
574093003210	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
574093003211	synthetase active site [active]
574093003212	NTP binding site [chemical binding]; other site
574093003213	metal binding site [ion binding]; metal-binding site
574093003214	Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762
574093003215	putative active site [active]
574093003216	putative metal binding residues [ion binding]; other site
574093003217	signature motif; other site
574093003218	putative triphosphate binding site [ion binding]; other site
574093003219	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458
574093003220	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
574093003221	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
574093003222	active site
574093003223	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
574093003224	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
574093003225	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
574093003226	catalytic residue [active]
574093003227	Putative amino acid metabolism; Region: DUF1831; pfam08866
574093003228	AT-rich DNA-binding protein [General function prediction only]; Region: COG2344
574093003229	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
574093003230	CoA binding domain; Region: CoA_binding; pfam02629
574093003231	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
574093003232	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
574093003233	catalytic triad [active]
574093003234	hypothetical protein; Reviewed; Region: PRK00024
574093003235	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
574093003236	MPN+ (JAMM) motif; other site
574093003237	Zinc-binding site [ion binding]; other site
574093003238	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
574093003239	Part of AAA domain; Region: AAA_19; pfam13245
574093003240	Family description; Region: UvrD_C_2; pfam13538
574093003241	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
574093003242	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
574093003243	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
574093003244	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
574093003245	active site
574093003246	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
574093003247	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
574093003248	DNA-binding site [nucleotide binding]; DNA binding site
574093003249	DRTGG domain; Region: DRTGG; pfam07085
574093003250	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
574093003251	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
574093003252	active site 2 [active]
574093003253	active site 1 [active]
574093003254	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
574093003255	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
574093003256	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
574093003257	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
574093003258	hinge; other site
574093003259	active site
574093003260	GTPase CgtA; Reviewed; Region: obgE; PRK12297
574093003261	GTP1/OBG; Region: GTP1_OBG; pfam01018
574093003262	Obg GTPase; Region: Obg; cd01898
574093003263	G1 box; other site
574093003264	GTP/Mg2+ binding site [chemical binding]; other site
574093003265	Switch I region; other site
574093003266	G2 box; other site
574093003267	G3 box; other site
574093003268	Switch II region; other site
574093003269	G4 box; other site
574093003270	G5 box; other site
574093003271	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
574093003272	Protein of unknown function (DUF4044); Region: DUF4044; pfam13253
574093003273	Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983
574093003274	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
574093003275	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
574093003276	putative ADP-binding pocket [chemical binding]; other site
574093003277	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
574093003278	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
574093003279	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
574093003280	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
574093003281	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
574093003282	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
574093003283	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
574093003284	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
574093003285	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
574093003286	DNA binding residues [nucleotide binding]
574093003287	DNA primase; Validated; Region: dnaG; PRK05667
574093003288	CHC2 zinc finger; Region: zf-CHC2; pfam01807
574093003289	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
574093003290	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
574093003291	active site
574093003292	metal binding site [ion binding]; metal-binding site
574093003293	interdomain interaction site; other site
574093003294	potential frameshift: common BLAST hit: gi|182684008|ref|YP_001835755.1| IS1239 transposase
574093003295	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
574093003296	Integrase core domain; Region: rve; pfam00665
574093003297	Helix-turn-helix domain; Region: HTH_38; pfam13936
574093003298	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
574093003299	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
574093003300	Walker A/P-loop; other site
574093003301	ATP binding site [chemical binding]; other site
574093003302	Q-loop/lid; other site
574093003303	ABC transporter signature motif; other site
574093003304	Walker B; other site
574093003305	D-loop; other site
574093003306	H-loop/switch region; other site
574093003307	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
574093003308	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
574093003309	TM-ABC transporter signature motif; other site
574093003310	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
574093003311	zinc binding site [ion binding]; other site
574093003312	putative ligand binding site [chemical binding]; other site
574093003313	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
574093003314	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
574093003315	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
574093003316	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
574093003317	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
574093003318	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
574093003319	sequence-specific DNA binding site [nucleotide binding]; other site
574093003320	salt bridge; other site
574093003321	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
574093003322	Ferroportin1 (FPN1); Region: FPN1; pfam06963
574093003323	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
574093003324	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
574093003325	DDE superfamily endonuclease; Region: DDE_4; cl17710
574093003326	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
574093003327	UDP-glucose 4-epimerase; Region: PLN02240
574093003328	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
574093003329	NAD binding site [chemical binding]; other site
574093003330	homodimer interface [polypeptide binding]; other site
574093003331	active site
574093003332	substrate binding site [chemical binding]; other site
574093003333	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
574093003334	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
574093003335	non-specific DNA binding site [nucleotide binding]; other site
574093003336	salt bridge; other site
574093003337	sequence-specific DNA binding site [nucleotide binding]; other site
574093003338	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
574093003339	Lantibiotic streptin immunity protein; Region: Streptin-Immun; pfam11083
574093003340	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
574093003341	homodimer interface [polypeptide binding]; other site
574093003342	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
574093003343	active site
574093003344	homodimer interface [polypeptide binding]; other site
574093003345	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
574093003346	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
574093003347	ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397
574093003348	Domain of unknown function (DUF4343); Region: DUF4343; pfam14243
574093003349	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
574093003350	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
574093003351	catalytic residues [active]
574093003352	catalytic nucleophile [active]
574093003353	Recombinase; Region: Recombinase; pfam07508
574093003354	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
574093003355	N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; cl09889
574093003356	Protein of unknown function (DUF3801); Region: DUF3801; pfam12687
574093003357	MobA/MobL family; Region: MobA_MobL; pfam03389
574093003358	Protein of unknown function (DUF3847); Region: DUF3847; pfam12958
574093003359	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
574093003360	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
574093003361	Walker A/P-loop; other site
574093003362	ATP binding site [chemical binding]; other site
574093003363	Q-loop/lid; other site
574093003364	ABC transporter signature motif; other site
574093003365	Walker B; other site
574093003366	D-loop; other site
574093003367	H-loop/switch region; other site
574093003368	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
574093003369	ABC-ATPase subunit  interface; other site
574093003370	dimer interface [polypeptide binding]; other site
574093003371	putative PBP binding regions; other site
574093003372	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
574093003373	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
574093003374	putative PBP binding regions; other site
574093003375	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
574093003376	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
574093003377	siderophore binding site; other site
574093003378	Predicted transcriptional regulator [Transcription]; Region: COG3655
574093003379	sequence-specific DNA binding site [nucleotide binding]; other site
574093003380	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
574093003381	TRAM domain; Region: TRAM; cl01282
574093003382	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
574093003383	S-adenosylmethionine binding site [chemical binding]; other site
574093003384	Predicted secreted protein [Function unknown]; Region: COG4086
574093003385	Protein of unknown function (DUF1002); Region: DUF1002; pfam06207
574093003386	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
574093003387	Lysozyme-like; Region: Lysozyme_like; pfam13702
574093003388	catalytic residue [active]
574093003389	37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473
574093003390	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
574093003391	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
574093003392	dimer interface [polypeptide binding]; other site
574093003393	active site
574093003394	glycine-pyridoxal phosphate binding site [chemical binding]; other site
574093003395	folate binding site [chemical binding]; other site
574093003396	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
574093003397	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
574093003398	Coenzyme A binding pocket [chemical binding]; other site
574093003399	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
574093003400	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
574093003401	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
574093003402	S-adenosylmethionine binding site [chemical binding]; other site
574093003403	peptide chain release factor 1; Validated; Region: prfA; PRK00591
574093003404	This domain is found in peptide chain release factors; Region: PCRF; smart00937
574093003405	RF-1 domain; Region: RF-1; pfam00472
574093003406	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
574093003407	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
574093003408	Coenzyme A binding pocket [chemical binding]; other site
574093003409	thymidine kinase; Provisional; Region: PRK04296
574093003410	4-oxalocrotonate tautomerase; Provisional; Region: PRK02289
574093003411	active site 1 [active]
574093003412	dimer interface [polypeptide binding]; other site
574093003413	hexamer interface [polypeptide binding]; other site
574093003414	active site 2 [active]
574093003415	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
574093003416	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
574093003417	trmE is a tRNA modification GTPase; Region: trmE; cd04164
574093003418	G1 box; other site
574093003419	GTP/Mg2+ binding site [chemical binding]; other site
574093003420	Switch I region; other site
574093003421	G2 box; other site
574093003422	Switch II region; other site
574093003423	G3 box; other site
574093003424	G4 box; other site
574093003425	G5 box; other site
574093003426	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
574093003427	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
574093003428	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
574093003429	dimer interface [polypeptide binding]; other site
574093003430	active site
574093003431	catalytic residue [active]
574093003432	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
574093003433	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
574093003434	Predicted membrane protein [Function unknown]; Region: COG4708
574093003435	Predicted membrane protein [Function unknown]; Region: COG2246
574093003436	GtrA-like protein; Region: GtrA; pfam04138
574093003437	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
574093003438	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
574093003439	Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276
574093003440	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
574093003441	active site
574093003442	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
574093003443	active site
574093003444	N-terminal domain interface [polypeptide binding]; other site
574093003445	Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826
574093003446	active site
574093003447	Sortase B (SrtB) or subfamily-2 sortases are membrane cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. This involves a transpeptidation reaction in which the...; Region: Sortase_B_2; cd05826
574093003448	active site
574093003449	catalytic site [active]
574093003450	T surface-antigen of pili; Region: FctA; cl16948
574093003451	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
574093003452	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
574093003453	Catalytic site [active]
574093003454	peptidase T; Region: peptidase-T; TIGR01882
574093003455	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
574093003456	metal binding site [ion binding]; metal-binding site
574093003457	dimer interface [polypeptide binding]; other site
574093003458	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
574093003459	potential frameshift: common BLAST hit: gi|298502980|ref|YP_003724920.1| histidine triad protein E precursor
574093003460	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
574093003461	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
574093003462	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
574093003463	streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363
574093003464	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
574093003465	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
574093003466	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
574093003467	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
574093003468	potential frameshift: common BLAST hit: gi|298502983|ref|YP_003724923.1| histidine triad protein B
574093003469	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
574093003470	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
574093003471	streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363
574093003472	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
574093003473	streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363
574093003474	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
574093003475	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
574093003476	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
574093003477	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
574093003478	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
574093003479	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
574093003480	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
574093003481	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
574093003482	dimerization domain swap beta strand [polypeptide binding]; other site
574093003483	regulatory protein interface [polypeptide binding]; other site
574093003484	active site
574093003485	regulatory phosphorylation site [posttranslational modification]; other site
574093003486	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
574093003487	catalytic residues [active]
574093003488	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306
574093003489	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
574093003490	Class I ribonucleotide reductase; Region: RNR_I; cd01679
574093003491	active site
574093003492	dimer interface [polypeptide binding]; other site
574093003493	catalytic residues [active]
574093003494	effector binding site; other site
574093003495	R2 peptide binding site; other site
574093003496	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
574093003497	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
574093003498	dimer interface [polypeptide binding]; other site
574093003499	putative radical transfer pathway; other site
574093003500	diiron center [ion binding]; other site
574093003501	tyrosyl radical; other site
574093003502	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
574093003503	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
574093003504	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
574093003505	Protein of unknown function (DUF3884); Region: DUF3884; pfam13024
574093003506	6-phospho-beta-galactosidase; Provisional; Region: PRK13511
574093003507	beta-galactosidase; Region: BGL; TIGR03356
574093003508	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295
574093003509	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
574093003510	PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565
574093003511	active site
574093003512	P-loop; other site
574093003513	phosphorylation site [posttranslational modification]
574093003514	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
574093003515	methionine cluster; other site
574093003516	active site
574093003517	phosphorylation site [posttranslational modification]
574093003518	metal binding site [ion binding]; metal-binding site
574093003519	CAT RNA binding domain; Region: CAT_RBD; smart01061
574093003520	transcriptional antiterminator BglG; Provisional; Region: PRK09772
574093003521	PRD domain; Region: PRD; pfam00874
574093003522	PRD domain; Region: PRD; pfam00874
574093003523	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399
574093003524	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
574093003525	tagatose-6-phosphate kinase; Region: lacC; TIGR01231
574093003526	putative substrate binding site [chemical binding]; other site
574093003527	putative ATP binding site [chemical binding]; other site
574093003528	galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622
574093003529	galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621
574093003530	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
574093003531	active site
574093003532	catalytic residues [active]
574093003533	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
574093003534	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
574093003535	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
574093003536	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
574093003537	active site
574093003538	phosphorylation site [posttranslational modification]
574093003539	GTP-binding protein LepA; Provisional; Region: PRK05433
574093003540	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
574093003541	G1 box; other site
574093003542	putative GEF interaction site [polypeptide binding]; other site
574093003543	GTP/Mg2+ binding site [chemical binding]; other site
574093003544	Switch I region; other site
574093003545	G2 box; other site
574093003546	G3 box; other site
574093003547	Switch II region; other site
574093003548	G4 box; other site
574093003549	G5 box; other site
574093003550	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
574093003551	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
574093003552	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
574093003553	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
574093003554	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
574093003555	active site
574093003556	metal binding site [ion binding]; metal-binding site
574093003557	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
574093003558	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
574093003559	Walker A/P-loop; other site
574093003560	ATP binding site [chemical binding]; other site
574093003561	Q-loop/lid; other site
574093003562	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
574093003563	ABC transporter signature motif; other site
574093003564	Walker B; other site
574093003565	D-loop; other site
574093003566	H-loop/switch region; other site
574093003567	Arginine repressor [Transcription]; Region: ArgR; COG1438
574093003568	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
574093003569	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
574093003570	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
574093003571	S4 RNA-binding domain; Region: S4; smart00363
574093003572	RNA binding surface [nucleotide binding]; other site
574093003573	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
574093003574	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
574093003575	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
574093003576	substrate binding pocket [chemical binding]; other site
574093003577	chain length determination region; other site
574093003578	substrate-Mg2+ binding site; other site
574093003579	catalytic residues [active]
574093003580	aspartate-rich region 1; other site
574093003581	active site lid residues [active]
574093003582	aspartate-rich region 2; other site
574093003583	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
574093003584	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
574093003585	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
574093003586	generic binding surface II; other site
574093003587	generic binding surface I; other site
574093003588	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
574093003589	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
574093003590	Sugar specificity; other site
574093003591	Pyrimidine base specificity; other site
574093003592	ATP-binding site [chemical binding]; other site
574093003593	Enterocin A Immunity; Region: EntA_Immun; pfam08951
574093003594	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484
574093003595	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
574093003596	RNA binding site [nucleotide binding]; other site
574093003597	active site
574093003598	tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
574093003599	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
574093003600	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
574093003601	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487
574093003602	Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903
574093003603	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
574093003604	hypothetical protein; Provisional; Region: PRK05939
574093003605	homodimer interface [polypeptide binding]; other site
574093003606	substrate-cofactor binding pocket; other site
574093003607	pyridoxal 5'-phosphate binding site [chemical binding]; other site
574093003608	catalytic residue [active]
574093003609	Dppa2/4 conserved region; Region: DCR; pfam14047
574093003610	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
574093003611	Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165
574093003612	active site
574093003613	catalytic site [active]
574093003614	DNA gyrase subunit A; Validated; Region: PRK05560
574093003615	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
574093003616	CAP-like domain; other site
574093003617	active site
574093003618	primary dimer interface [polypeptide binding]; other site
574093003619	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
574093003620	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
574093003621	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
574093003622	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
574093003623	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
574093003624	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
574093003625	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
574093003626	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
574093003627	tetramer (dimer of dimers) interface [polypeptide binding]; other site
574093003628	NAD binding site [chemical binding]; other site
574093003629	dimer interface [polypeptide binding]; other site
574093003630	substrate binding site [chemical binding]; other site
574093003631	Ion channel; Region: Ion_trans_2; pfam07885
574093003632	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
574093003633	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
574093003634	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
574093003635	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
574093003636	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
574093003637	putative active site [active]
574093003638	heme pocket [chemical binding]; other site
574093003639	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
574093003640	dimer interface [polypeptide binding]; other site
574093003641	phosphorylation site [posttranslational modification]
574093003642	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
574093003643	ATP binding site [chemical binding]; other site
574093003644	Mg2+ binding site [ion binding]; other site
574093003645	G-X-G motif; other site
574093003646	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
574093003647	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
574093003648	active site
574093003649	phosphorylation site [posttranslational modification]
574093003650	intermolecular recognition site; other site
574093003651	dimerization interface [polypeptide binding]; other site
574093003652	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
574093003653	DNA binding site [nucleotide binding]
574093003654	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
574093003655	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
574093003656	minor groove reading motif; other site
574093003657	helix-hairpin-helix signature motif; other site
574093003658	substrate binding pocket [chemical binding]; other site
574093003659	active site
574093003660	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
574093003661	DNA binding and oxoG recognition site [nucleotide binding]
574093003662	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
574093003663	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
574093003664	Potassium binding sites [ion binding]; other site
574093003665	Cesium cation binding sites [ion binding]; other site
574093003666	phosphopantothenate--cysteine ligase; Validated; Region: PRK06732
574093003667	phosphopantothenoylcysteine decarboxylase, streptococcal; Region: coaC_strep; TIGR02113
574093003668	Flavoprotein; Region: Flavoprotein; pfam02441
574093003669	Predicted membrane protein [Function unknown]; Region: COG4684
574093003670	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
574093003671	HTH domain; Region: HTH_11; pfam08279
574093003672	3H domain; Region: 3H; pfam02829
574093003673	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
574093003674	putative active site [active]
574093003675	nucleotide binding site [chemical binding]; other site
574093003676	nudix motif; other site
574093003677	putative metal binding site [ion binding]; other site
574093003678	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
574093003679	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
574093003680	excinuclease ABC subunit B; Provisional; Region: PRK05298
574093003681	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
574093003682	ATP binding site [chemical binding]; other site
574093003683	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
574093003684	nucleotide binding region [chemical binding]; other site
574093003685	ATP-binding site [chemical binding]; other site
574093003686	Ultra-violet resistance protein B; Region: UvrB; pfam12344
574093003687	UvrB/uvrC motif; Region: UVR; pfam02151
574093003688	CAAX protease self-immunity; Region: Abi; pfam02517
574093003689	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
574093003690	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
574093003691	substrate binding pocket [chemical binding]; other site
574093003692	membrane-bound complex binding site; other site
574093003693	hinge residues; other site
574093003694	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
574093003695	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
574093003696	substrate binding pocket [chemical binding]; other site
574093003697	membrane-bound complex binding site; other site
574093003698	hinge residues; other site
574093003699	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
574093003700	dimer interface [polypeptide binding]; other site
574093003701	conserved gate region; other site
574093003702	putative PBP binding loops; other site
574093003703	ABC-ATPase subunit interface; other site
574093003704	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
574093003705	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
574093003706	Walker A/P-loop; other site
574093003707	ATP binding site [chemical binding]; other site
574093003708	Q-loop/lid; other site
574093003709	ABC transporter signature motif; other site
574093003710	Walker B; other site
574093003711	D-loop; other site
574093003712	H-loop/switch region; other site
574093003713	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
574093003714	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
574093003715	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
574093003716	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
574093003717	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
574093003718	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
574093003719	P loop; other site
574093003720	GTP binding site [chemical binding]; other site
574093003721	sugar phosphate phosphatase; Provisional; Region: PRK10513
574093003722	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
574093003723	motif II; other site
574093003724	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
574093003725	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
574093003726	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
574093003727	active site
574093003728	motif I; other site
574093003729	motif II; other site
574093003730	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
574093003731	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
574093003732	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
574093003733	Walker A/P-loop; other site
574093003734	ATP binding site [chemical binding]; other site
574093003735	Q-loop/lid; other site
574093003736	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
574093003737	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
574093003738	ABC transporter signature motif; other site
574093003739	Walker B; other site
574093003740	D-loop; other site
574093003741	H-loop/switch region; other site
574093003742	ribonuclease III; Reviewed; Region: rnc; PRK00102
574093003743	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
574093003744	dimerization interface [polypeptide binding]; other site
574093003745	active site
574093003746	metal binding site [ion binding]; metal-binding site
574093003747	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
574093003748	dsRNA binding site [nucleotide binding]; other site
574093003749	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
574093003750	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
574093003751	active site
574093003752	McrBC 5-methylcytosine restriction system component [Defense mechanisms]; Region: McrC; COG4268
574093003753	GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401
574093003754	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
574093003755	Walker A motif; other site
574093003756	ATP binding site [chemical binding]; other site
574093003757	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
574093003758	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
574093003759	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
574093003760	substrate binding site [chemical binding]; other site
574093003761	Predicted membrane protein [Function unknown]; Region: COG3326
574093003762	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
574093003763	tartrate dehydrogenase; Region: TTC; TIGR02089
574093003764	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
574093003765	DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974
574093003766	metal binding site [ion binding]; metal-binding site
574093003767	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
574093003768	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
574093003769	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
574093003770	DNA topoisomerase I; Validated; Region: PRK05582
574093003771	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
574093003772	active site
574093003773	interdomain interaction site; other site
574093003774	putative metal-binding site [ion binding]; other site
574093003775	nucleotide binding site [chemical binding]; other site
574093003776	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
574093003777	domain I; other site
574093003778	DNA binding groove [nucleotide binding]
574093003779	phosphate binding site [ion binding]; other site
574093003780	domain II; other site
574093003781	domain III; other site
574093003782	nucleotide binding site [chemical binding]; other site
574093003783	catalytic site [active]
574093003784	domain IV; other site
574093003785	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
574093003786	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
574093003787	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
574093003788	Predicted membrane protein [Function unknown]; Region: COG1808
574093003789	potential frameshift: common BLAST hit: gi|182684008|ref|YP_001835755.1| IS1239 transposase
574093003790	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
574093003791	Helix-turn-helix domain; Region: HTH_38; pfam13936
574093003792	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
574093003793	Integrase core domain; Region: rve; pfam00665
574093003794	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
574093003795	DNA protecting protein DprA; Region: dprA; TIGR00732
574093003796	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
574093003797	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
574093003798	active site
574093003799	metal-binding site
574093003800	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
574093003801	Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151
574093003802	Phosphotransferase enzyme family; Region: APH; pfam01636
574093003803	active site
574093003804	substrate binding site [chemical binding]; other site
574093003805	ATP binding site [chemical binding]; other site
574093003806	dimer interface [polypeptide binding]; other site
574093003807	ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237
574093003808	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
574093003809	putative NAD(P) binding site [chemical binding]; other site
574093003810	putative catalytic Zn binding site [ion binding]; other site
574093003811	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
574093003812	substrate binding site; other site
574093003813	dimer interface; other site
574093003814	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
574093003815	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
574093003816	LPS biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3475
574093003817	LPS biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3475
574093003818	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
574093003819	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
574093003820	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
574093003821	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
574093003822	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
574093003823	ATP-grasp domain; Region: ATP-grasp_4; cl17255
574093003824	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
574093003825	IMP binding site; other site
574093003826	dimer interface [polypeptide binding]; other site
574093003827	interdomain contacts; other site
574093003828	partial ornithine binding site; other site
574093003829	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
574093003830	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
574093003831	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
574093003832	catalytic site [active]
574093003833	subunit interface [polypeptide binding]; other site
574093003834	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
574093003835	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
574093003836	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
574093003837	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
574093003838	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
574093003839	active site
574093003840	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
574093003841	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
574093003842	minor groove reading motif; other site
574093003843	helix-hairpin-helix signature motif; other site
574093003844	substrate binding pocket [chemical binding]; other site
574093003845	active site
574093003846	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
574093003847	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
574093003848	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
574093003849	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
574093003850	heat shock protein HtpX; Provisional; Region: PRK04897
574093003851	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
574093003852	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
574093003853	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
574093003854	S-adenosylmethionine binding site [chemical binding]; other site
574093003855	uracil transporter; Provisional; Region: PRK10720
574093003856	signal recognition particle protein; Provisional; Region: PRK10867
574093003857	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
574093003858	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
574093003859	P loop; other site
574093003860	GTP binding site [chemical binding]; other site
574093003861	Signal peptide binding domain; Region: SRP_SPB; pfam02978
574093003862	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
574093003863	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
574093003864	Domain of unknown function (DUF1934); Region: DUF1934; pfam09148
574093003865	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
574093003866	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
574093003867	Zn2+ binding site [ion binding]; other site
574093003868	Mg2+ binding site [ion binding]; other site
574093003869	sugar phosphate phosphatase; Provisional; Region: PRK10513
574093003870	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
574093003871	active site
574093003872	motif I; other site
574093003873	motif II; other site
574093003874	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
574093003875	SAP domain; Region: SAP; pfam02037
574093003876	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
574093003877	camphor resistance protein CrcB; Provisional; Region: PRK14229
574093003878	camphor resistance protein CrcB; Provisional; Region: PRK14221
574093003879	hypothetical protein; Provisional; Region: PRK07248
574093003880	flavodoxin; Validated; Region: PRK07308
574093003881	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
574093003882	DHH family; Region: DHH; pfam01368
574093003883	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
574093003884	Winged helix-turn helix; Region: HTH_29; pfam13551
574093003885	Homeodomain-like domain; Region: HTH_23; pfam13384
574093003886	Homeodomain-like domain; Region: HTH_32; pfam13565
574093003887	glutamate dehydrogenase; Provisional; Region: PRK09414
574093003888	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
574093003889	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
574093003890	NAD(P) binding site [chemical binding]; other site
574093003891	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
574093003892	ABC transporter signature motif; other site
574093003893	Walker B; other site
574093003894	D-loop; other site
574093003895	H-loop/switch region; other site
574093003896	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
574093003897	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
574093003898	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
574093003899	Homeodomain-like domain; Region: HTH_23; pfam13384
574093003900	Winged helix-turn helix; Region: HTH_29; pfam13551
574093003901	DDE superfamily endonuclease; Region: DDE_3; pfam13358
574093003902	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
574093003903	Homeodomain-like domain; Region: HTH_23; cl17451
574093003904	putative transposase OrfB; Reviewed; Region: PHA02517
574093003905	HTH-like domain; Region: HTH_21; pfam13276
574093003906	Integrase core domain; Region: rve; pfam00665
574093003907	Integrase core domain; Region: rve_2; pfam13333
574093003908	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
574093003909	Q-loop/lid; other site
574093003910	ABC transporter signature motif; other site
574093003911	V-type ATP synthase subunit D; Reviewed; Region: PRK00373
574093003912	V-type ATP synthase subunit B; Provisional; Region: PRK04196
574093003913	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
574093003914	V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135
574093003915	Walker A motif homologous position; other site
574093003916	Walker B motif; other site
574093003917	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
574093003918	V-type ATP synthase subunit A; Provisional; Region: PRK04192
574093003919	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
574093003920	V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction.  The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134
574093003921	Walker A motif/ATP binding site; other site
574093003922	Walker B motif; other site
574093003923	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
574093003924	V-type ATP synthase subunit F; Provisional; Region: PRK01395
574093003925	Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527
574093003926	V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660
574093003927	Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390
574093003928	V-type ATP synthase subunit K; Validated; Region: PRK06558
574093003929	ATP synthase subunit C; Region: ATP-synt_C; pfam00137
574093003930	ATP synthase subunit C; Region: ATP-synt_C; pfam00137
574093003931	V-type ATP synthase subunit I; Validated; Region: PRK05771
574093003932	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
574093003933	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
574093003934	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
574093003935	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
574093003936	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
574093003937	Neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: NanH; COG4409
574093003938	Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated...; Region: PTX; cl00102
574093003939	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
574093003940	Asp-box motif; other site
574093003941	catalytic site [active]
574093003942	Domain of unknown function (DUF386); Region: DUF386; pfam04074
574093003943	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495
574093003944	Na binding site [ion binding]; other site
574093003945	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
574093003946	N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954
574093003947	inhibitor site; inhibition site
574093003948	active site
574093003949	dimer interface [polypeptide binding]; other site
574093003950	catalytic residue [active]
574093003951	Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010
574093003952	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
574093003953	putative active site cavity [active]
574093003954	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
574093003955	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
574093003956	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
574093003957	putative active site [active]
574093003958	Arsenate reductase and related proteins, glutaredoxin family [Inorganic ion transport and metabolism]; Region: ArsC; COG1393
574093003959	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270
574093003960	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
574093003961	cofactor binding site; other site
574093003962	DNA binding site [nucleotide binding]
574093003963	substrate interaction site [chemical binding]; other site
574093003964	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
574093003965	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
574093003966	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
574093003967	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
574093003968	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
574093003969	Walker A/P-loop; other site
574093003970	ATP binding site [chemical binding]; other site
574093003971	Q-loop/lid; other site
574093003972	ABC transporter signature motif; other site
574093003973	Walker B; other site
574093003974	D-loop; other site
574093003975	H-loop/switch region; other site
574093003976	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
574093003977	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
574093003978	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
574093003979	Walker A/P-loop; other site
574093003980	ATP binding site [chemical binding]; other site
574093003981	Q-loop/lid; other site
574093003982	ABC transporter signature motif; other site
574093003983	Walker B; other site
574093003984	D-loop; other site
574093003985	H-loop/switch region; other site
574093003986	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
574093003987	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
574093003988	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
574093003989	active site
574093003990	ATP binding site [chemical binding]; other site
574093003991	Lanthionine synthetase C-like domain associated with serine threonine kinases. Some members of this subgroup lack the zinc binding site and the active site residues, and therefore are most likely inactive. The function of this domain is unknown; Region: LanC_SerThrkinase; cd04791
574093003992	Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147
574093003993	active site
574093003994	zinc binding site [ion binding]; other site
574093003995	CAAX protease self-immunity; Region: Abi; pfam02517
574093003996	Arsenate reductase and related proteins, glutaredoxin family [Inorganic ion transport and metabolism]; Region: ArsC; COG1393
574093003997	ArsC family; Region: ArsC; pfam03960
574093003998	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
574093003999	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
574093004000	core dimer interface [polypeptide binding]; other site
574093004001	L10 interface [polypeptide binding]; other site
574093004002	L11 interface [polypeptide binding]; other site
574093004003	putative EF-Tu interaction site [polypeptide binding]; other site
574093004004	putative EF-G interaction site [polypeptide binding]; other site
574093004005	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
574093004006	23S rRNA interface [nucleotide binding]; other site
574093004007	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
574093004008	chlorohydrolase; Validated; Region: PRK06687
574093004009	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
574093004010	active site
574093004011	putative substrate binding pocket [chemical binding]; other site
574093004012	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
574093004013	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
574093004014	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
574093004015	Walker A/P-loop; other site
574093004016	ATP binding site [chemical binding]; other site
574093004017	Q-loop/lid; other site
574093004018	ABC transporter signature motif; other site
574093004019	Walker B; other site
574093004020	D-loop; other site
574093004021	H-loop/switch region; other site
574093004022	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
574093004023	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
574093004024	APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination; Region: APC10-like; cl02148
574093004025	putative ligand binding site [chemical binding]; other site
574093004026	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
574093004027	Walker A/P-loop; other site
574093004028	ATP binding site [chemical binding]; other site
574093004029	Q-loop/lid; other site
574093004030	ABC transporter signature motif; other site
574093004031	Walker B; other site
574093004032	D-loop; other site
574093004033	H-loop/switch region; other site
574093004034	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
574093004035	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
574093004036	SelR domain; Region: SelR; pfam01641
574093004037	homoserine kinase; Provisional; Region: PRK01212
574093004038	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
574093004039	homoserine dehydrogenase; Provisional; Region: PRK06349
574093004040	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
574093004041	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
574093004042	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
574093004043	adaptor protein; Provisional; Region: PRK02315
574093004044	O-antigen polysaccharide polymerase Wzy; Region: O-ag_pol_Wzy; pfam14296
574093004045	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
574093004046	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
574093004047	active site
574093004048	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
574093004049	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
574093004050	putative ADP-binding pocket [chemical binding]; other site
574093004051	LPS biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3475
574093004052	Transcriptional regulator [Transcription]; Region: LytR; COG1316
574093004053	prephenate dehydratase; Provisional; Region: PRK11898
574093004054	Prephenate dehydratase; Region: PDT; pfam00800
574093004055	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
574093004056	putative L-Phe binding site [chemical binding]; other site
574093004057	shikimate kinase; Reviewed; Region: aroK; PRK00131
574093004058	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
574093004059	ADP binding site [chemical binding]; other site
574093004060	magnesium binding site [ion binding]; other site
574093004061	putative shikimate binding site; other site
574093004062	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
574093004063	Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554
574093004064	hinge; other site
574093004065	active site
574093004066	Protein of unknown function (DUF964); Region: DUF964; cl01483
574093004067	Protein of unknown function (DUF964); Region: DUF964; cl01483
574093004068	prephenate dehydrogenase; Validated; Region: PRK06545
574093004069	prephenate dehydrogenase; Validated; Region: PRK08507
574093004070	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
574093004071	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
574093004072	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
574093004073	Tetramer interface [polypeptide binding]; other site
574093004074	active site
574093004075	FMN-binding site [chemical binding]; other site
574093004076	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
574093004077	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
574093004078	active site
574093004079	dimer interface [polypeptide binding]; other site
574093004080	metal binding site [ion binding]; metal-binding site
574093004081	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
574093004082	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
574093004083	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
574093004084	shikimate binding site; other site
574093004085	NAD(P) binding site [chemical binding]; other site
574093004086	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
574093004087	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
574093004088	active site
574093004089	catalytic residue [active]
574093004090	dimer interface [polypeptide binding]; other site
574093004091	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
574093004092	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
574093004093	putative RNA binding site [nucleotide binding]; other site
574093004094	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
574093004095	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
574093004096	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
574093004097	Walker A/P-loop; other site
574093004098	ATP binding site [chemical binding]; other site
574093004099	Q-loop/lid; other site
574093004100	ABC transporter signature motif; other site
574093004101	Walker B; other site
574093004102	D-loop; other site
574093004103	H-loop/switch region; other site
574093004104	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
574093004105	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
574093004106	active site
574093004107	Na/Ca binding site [ion binding]; other site
574093004108	catalytic site [active]
574093004109	Domain of unknown function (DUF1939); Region: DUF1939; pfam09154
574093004110	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
574093004111	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
574093004112	motif 1; other site
574093004113	active site
574093004114	motif 2; other site
574093004115	motif 3; other site
574093004116	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
574093004117	DHHA1 domain; Region: DHHA1; pfam02272
574093004118	Uncharacterized conserved protein [Function unknown]; Region: COG4894
574093004119	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
574093004120	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
574093004121	DDE superfamily endonuclease; Region: DDE_4; cl17710
574093004122	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
574093004123	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
574093004124	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
574093004125	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
574093004126	dimer interface [polypeptide binding]; other site
574093004127	conserved gate region; other site
574093004128	putative PBP binding loops; other site
574093004129	ABC-ATPase subunit interface; other site
574093004130	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
574093004131	dimer interface [polypeptide binding]; other site
574093004132	conserved gate region; other site
574093004133	putative PBP binding loops; other site
574093004134	ABC-ATPase subunit interface; other site
574093004135	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
574093004136	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
574093004137	Walker A/P-loop; other site
574093004138	ATP binding site [chemical binding]; other site
574093004139	Q-loop/lid; other site
574093004140	ABC transporter signature motif; other site
574093004141	Walker B; other site
574093004142	D-loop; other site
574093004143	H-loop/switch region; other site
574093004144	TOBE domain; Region: TOBE_2; pfam08402
574093004145	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
574093004146	FAD binding domain; Region: FAD_binding_4; pfam01565
574093004147	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
574093004148	Putative membrane peptidase family (DUF2324); Region: DUF2324; cl01810
574093004149	Putative membrane peptidase family (DUF2324); Region: DUF2324; cl01810
574093004150	Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527
574093004151	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
574093004152	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
574093004153	DNA-binding site [nucleotide binding]; DNA binding site
574093004154	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
574093004155	pyridoxal 5'-phosphate binding site [chemical binding]; other site
574093004156	homodimer interface [polypeptide binding]; other site
574093004157	catalytic residue [active]
574093004158	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
574093004159	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
574093004160	substrate binding pocket [chemical binding]; other site
574093004161	membrane-bound complex binding site; other site
574093004162	hinge residues; other site
574093004163	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
574093004164	PhoU domain; Region: PhoU; pfam01895
574093004165	PhoU domain; Region: PhoU; pfam01895
574093004166	phosphate transporter ATP-binding protein; Provisional; Region: PRK14239
574093004167	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
574093004168	Walker A/P-loop; other site
574093004169	ATP binding site [chemical binding]; other site
574093004170	Q-loop/lid; other site
574093004171	ABC transporter signature motif; other site
574093004172	Walker B; other site
574093004173	D-loop; other site
574093004174	H-loop/switch region; other site
574093004175	phosphate transporter ATP-binding protein; Provisional; Region: PRK14237
574093004176	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
574093004177	Walker A/P-loop; other site
574093004178	ATP binding site [chemical binding]; other site
574093004179	Q-loop/lid; other site
574093004180	ABC transporter signature motif; other site
574093004181	Walker B; other site
574093004182	D-loop; other site
574093004183	H-loop/switch region; other site
574093004184	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
574093004185	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
574093004186	dimer interface [polypeptide binding]; other site
574093004187	conserved gate region; other site
574093004188	putative PBP binding loops; other site
574093004189	ABC-ATPase subunit interface; other site
574093004190	sulfate transport protein; Provisional; Region: cysT; CHL00187
574093004191	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
574093004192	dimer interface [polypeptide binding]; other site
574093004193	conserved gate region; other site
574093004194	putative PBP binding loops; other site
574093004195	ABC-ATPase subunit interface; other site
574093004196	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
574093004197	phosphate binding protein; Region: ptsS_2; TIGR02136
574093004198	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
574093004199	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
574093004200	S-adenosylmethionine binding site [chemical binding]; other site
574093004201	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
574093004202	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
574093004203	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
574093004204	active site
574093004205	hypothetical protein; Provisional; Region: PRK04387
574093004206	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
574093004207	ArsC family; Region: ArsC; pfam03960
574093004208	putative catalytic residues [active]
574093004209	thiol/disulfide switch; other site
574093004210	Predicted membrane protein [Function unknown]; Region: COG4478
574093004211	HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2
574093004212	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
574093004213	active site
574093004214	motif I; other site
574093004215	motif II; other site
574093004216	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
574093004217	Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884
574093004218	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
574093004219	active site
574093004220	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
574093004221	active site
574093004222	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
574093004223	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
574093004224	FeS/SAM binding site; other site
574093004225	HemN C-terminal domain; Region: HemN_C; pfam06969
574093004226	YtxH-like protein; Region: YtxH; pfam12732
574093004227	Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768
574093004228	Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790
574093004229	HPr kinase/phosphorylase; Provisional; Region: PRK05428
574093004230	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
574093004231	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
574093004232	Hpr binding site; other site
574093004233	active site
574093004234	homohexamer subunit interaction site [polypeptide binding]; other site
574093004235	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
574093004236	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
574093004237	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
574093004238	active site
574093004239	trimer interface [polypeptide binding]; other site
574093004240	allosteric site; other site
574093004241	active site lid [active]
574093004242	hexamer (dimer of trimers) interface [polypeptide binding]; other site
574093004243	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
574093004244	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
574093004245	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
574093004246	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
574093004247	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
574093004248	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
574093004249	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
574093004250	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
574093004251	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
574093004252	homodimer interface [polypeptide binding]; other site
574093004253	NAD binding pocket [chemical binding]; other site
574093004254	ATP binding pocket [chemical binding]; other site
574093004255	Mg binding site [ion binding]; other site
574093004256	active-site loop [active]
574093004257	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
574093004258	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
574093004259	active site
574093004260	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
574093004261	non-specific DNA binding site [nucleotide binding]; other site
574093004262	salt bridge; other site
574093004263	sequence-specific DNA binding site [nucleotide binding]; other site
574093004264	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
574093004265	ABC transporter; Region: ABC_tran; pfam00005
574093004266	Q-loop/lid; other site
574093004267	ABC transporter signature motif; other site
574093004268	Walker B; other site
574093004269	D-loop; other site
574093004270	H-loop/switch region; other site
574093004271	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
574093004272	Peptidase family U32; Region: Peptidase_U32; pfam01136
574093004273	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
574093004274	Zinc finger domain containing protein (CHY type) [Function unknown]; Region: COG4357
574093004275	CHY zinc finger; Region: zf-CHY; pfam05495
574093004276	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
574093004277	Peptidase family U32; Region: Peptidase_U32; pfam01136
574093004278	ApaLI-like restriction endonuclease; Region: RE_ApaLI; pfam09499
574093004279	ApaLI-like restriction endonuclease; Region: RE_ApaLI; pfam09499
574093004280	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
574093004281	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
574093004282	S-adenosylmethionine binding site [chemical binding]; other site
574093004283	Helix-turn-helix domain; Region: HTH_18; pfam12833
574093004284	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
574093004285	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
574093004286	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
574093004287	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
574093004288	Walker A/P-loop; other site
574093004289	ATP binding site [chemical binding]; other site
574093004290	Q-loop/lid; other site
574093004291	ABC transporter signature motif; other site
574093004292	Walker B; other site
574093004293	D-loop; other site
574093004294	H-loop/switch region; other site
574093004295	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
574093004296	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
574093004297	Walker A/P-loop; other site
574093004298	ATP binding site [chemical binding]; other site
574093004299	Q-loop/lid; other site
574093004300	ABC transporter signature motif; other site
574093004301	Walker B; other site
574093004302	D-loop; other site
574093004303	H-loop/switch region; other site
574093004304	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605
574093004305	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
574093004306	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
574093004307	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
574093004308	Walker A/P-loop; other site
574093004309	ATP binding site [chemical binding]; other site
574093004310	Q-loop/lid; other site
574093004311	ABC transporter signature motif; other site
574093004312	Walker B; other site
574093004313	D-loop; other site
574093004314	H-loop/switch region; other site
574093004315	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
574093004316	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
574093004317	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
574093004318	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
574093004319	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
574093004320	GMP synthase; Reviewed; Region: guaA; PRK00074
574093004321	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
574093004322	AMP/PPi binding site [chemical binding]; other site
574093004323	candidate oxyanion hole; other site
574093004324	catalytic triad [active]
574093004325	potential glutamine specificity residues [chemical binding]; other site
574093004326	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
574093004327	ATP Binding subdomain [chemical binding]; other site
574093004328	Dimerization subdomain; other site
574093004329	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
574093004330	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
574093004331	DNA-binding site [nucleotide binding]; DNA binding site
574093004332	UTRA domain; Region: UTRA; pfam07702
574093004333	EamA-like transporter family; Region: EamA; pfam00892
574093004334	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
574093004335	Beta-lactamase; Region: Beta-lactamase; pfam00144
574093004336	NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841
574093004337	active site
574093004338	catalytic triad [active]
574093004339	oxyanion hole [active]
574093004340	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
574093004341	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
574093004342	active site
574093004343	motif I; other site
574093004344	motif II; other site
574093004345	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
574093004346	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
574093004347	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
574093004348	putative active site [active]
574093004349	putative metal binding site [ion binding]; other site
574093004350	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
574093004351	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
574093004352	active site
574093004353	catalytic residues [active]
574093004354	metal binding site [ion binding]; metal-binding site
574093004355	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
574093004356	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
574093004357	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
574093004358	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
574093004359	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
574093004360	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
574093004361	Protein of unknown function (DUF4059); Region: DUF4059; pfam13268
574093004362	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
574093004363	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
574093004364	Walker A/P-loop; other site
574093004365	ATP binding site [chemical binding]; other site
574093004366	Q-loop/lid; other site
574093004367	ABC transporter signature motif; other site
574093004368	Walker B; other site
574093004369	D-loop; other site
574093004370	H-loop/switch region; other site
574093004371	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
574093004372	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
574093004373	ABC-ATPase subunit interface; other site
574093004374	putative PBP binding loops; other site
574093004375	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
574093004376	putative ArsC-like catalytic residues; other site
574093004377	putative TRX-like catalytic residues [active]
574093004378	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
574093004379	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
574093004380	DNA binding site [nucleotide binding]
574093004381	active site
574093004382	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
574093004383	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
574093004384	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
574093004385	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
574093004386	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
574093004387	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
574093004388	predicted active site [active]
574093004389	catalytic triad [active]
574093004390	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
574093004391	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
574093004392	active site
574093004393	multimer interface [polypeptide binding]; other site
574093004394	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
574093004395	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
574093004396	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
574093004397	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
574093004398	ApbE family; Region: ApbE; pfam02424
574093004399	Predicted flavoprotein [General function prediction only]; Region: COG0431
574093004400	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
574093004401	Predicted flavoprotein [General function prediction only]; Region: COG0431
574093004402	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
574093004403	PAS domain; Region: PAS_10; pfam13596
574093004404	hypothetical protein; Provisional; Region: PRK02539
574093004405	Glycyl-tRNA synthetase, beta subunit [Translation, ribosomal structure and biogenesis]; Region: GlyS; COG0751
574093004406	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471
574093004407	DALR anticodon binding domain; Region: DALR_1; pfam05746
574093004408	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
574093004409	dimer interface [polypeptide binding]; other site
574093004410	motif 1; other site
574093004411	active site
574093004412	motif 2; other site
574093004413	motif 3; other site
574093004414	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
574093004415	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
574093004416	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
574093004417	active site
574093004418	catalytic tetrad [active]
574093004419	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
574093004420	Catalytic NodB homology domain of Streptococcus pneumoniae peptidoglycan deacetylase PgdA, Bacillus subtilis BsYjeA protein, and their bacterial homologs; Region: CE4_SpPgdA_BsYjeA_like; cd10947
574093004421	NodB motif; other site
574093004422	active site
574093004423	catalytic site [active]
574093004424	Zn binding site [ion binding]; other site
574093004425	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
574093004426	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
574093004427	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
574093004428	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
574093004429	DEAD-like helicases superfamily; Region: DEXDc; smart00487
574093004430	ATP binding site [chemical binding]; other site
574093004431	putative Mg++ binding site [ion binding]; other site
574093004432	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
574093004433	nucleotide binding region [chemical binding]; other site
574093004434	ATP-binding site [chemical binding]; other site
574093004435	DDE superfamily endonuclease; Region: DDE_3; pfam13358
574093004436	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
574093004437	Winged helix-turn helix; Region: HTH_29; pfam13551
574093004438	Winged helix-turn helix; Region: HTH_33; pfam13592
574093004439	elongation factor Tu; Reviewed; Region: PRK00049
574093004440	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
574093004441	G1 box; other site
574093004442	GEF interaction site [polypeptide binding]; other site
574093004443	GTP/Mg2+ binding site [chemical binding]; other site
574093004444	Switch I region; other site
574093004445	G2 box; other site
574093004446	G3 box; other site
574093004447	Switch II region; other site
574093004448	G4 box; other site
574093004449	G5 box; other site
574093004450	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
574093004451	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
574093004452	Antibiotic Binding Site [chemical binding]; other site
574093004453	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
574093004454	Helix-turn-helix domain; Region: HTH_38; pfam13936
574093004455	Integrase core domain; Region: rve; pfam00665
574093004456	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
574093004457	amphipathic channel; other site
574093004458	Asn-Pro-Ala signature motifs; other site
574093004459	MucBP domain; Region: MucBP; pfam06458
574093004460	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
574093004461	DDE superfamily endonuclease; Region: DDE_3; pfam13358
574093004462	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
574093004463	Transposase; Region: HTH_Tnp_IS630; pfam01710
574093004464	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
574093004465	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
574093004466	active site
574093004467	substrate binding site [chemical binding]; other site
574093004468	metal binding site [ion binding]; metal-binding site
574093004469	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
574093004470	catalytic residues [active]
574093004471	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
574093004472	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
574093004473	substrate binding pocket [chemical binding]; other site
574093004474	membrane-bound complex binding site; other site
574093004475	hinge residues; other site
574093004476	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
574093004477	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
574093004478	Walker A/P-loop; other site
574093004479	ATP binding site [chemical binding]; other site
574093004480	Q-loop/lid; other site
574093004481	ABC transporter signature motif; other site
574093004482	Walker B; other site
574093004483	D-loop; other site
574093004484	H-loop/switch region; other site
574093004485	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
574093004486	dimer interface [polypeptide binding]; other site
574093004487	conserved gate region; other site
574093004488	putative PBP binding loops; other site
574093004489	ABC-ATPase subunit interface; other site
574093004490	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
574093004491	TPR motif; other site
574093004492	binding surface
574093004493	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
574093004494	binding surface
574093004495	TPR motif; other site
574093004496	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
574093004497	Domain of unknown function DUF20; Region: UPF0118; pfam01594
574093004498	3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706
574093004499	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
574093004500	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
574093004501	gamma subunit interface [polypeptide binding]; other site
574093004502	epsilon subunit interface [polypeptide binding]; other site
574093004503	LBP interface [polypeptide binding]; other site
574093004504	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
574093004505	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
574093004506	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
574093004507	alpha subunit interaction interface [polypeptide binding]; other site
574093004508	Walker A motif; other site
574093004509	ATP binding site [chemical binding]; other site
574093004510	Walker B motif; other site
574093004511	inhibitor binding site; inhibition site
574093004512	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
574093004513	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
574093004514	core domain interface [polypeptide binding]; other site
574093004515	delta subunit interface [polypeptide binding]; other site
574093004516	epsilon subunit interface [polypeptide binding]; other site
574093004517	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
574093004518	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
574093004519	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
574093004520	beta subunit interaction interface [polypeptide binding]; other site
574093004521	Walker A motif; other site
574093004522	ATP binding site [chemical binding]; other site
574093004523	Walker B motif; other site
574093004524	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
574093004525	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
574093004526	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
574093004527	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
574093004528	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
574093004529	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
574093004530	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
574093004531	F0F1 ATP synthase subunit C; Provisional; Region: PRK13467
574093004532	Helix-turn-helix domain; Region: HTH_38; pfam13936
574093004533	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
574093004534	Integrase core domain; Region: rve; pfam00665
574093004535	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
574093004536	Coenzyme A binding pocket [chemical binding]; other site
574093004537	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
574093004538	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
574093004539	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
574093004540	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
574093004541	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
574093004542	dimerization interface [polypeptide binding]; other site
574093004543	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
574093004544	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
574093004545	Coenzyme A binding pocket [chemical binding]; other site
574093004546	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
574093004547	Coenzyme A binding pocket [chemical binding]; other site
574093004548	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
574093004549	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
574093004550	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
574093004551	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
574093004552	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
574093004553	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
574093004554	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
574093004555	ATP binding site [chemical binding]; other site
574093004556	putative Mg++ binding site [ion binding]; other site
574093004557	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
574093004558	nucleotide binding region [chemical binding]; other site
574093004559	ATP-binding site [chemical binding]; other site
574093004560	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
574093004561	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
574093004562	pyridoxal 5'-phosphate binding site [chemical binding]; other site
574093004563	homodimer interface [polypeptide binding]; other site
574093004564	catalytic residue [active]
574093004565	cystathionine gamma-synthase; Reviewed; Region: PRK07269
574093004566	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
574093004567	homodimer interface [polypeptide binding]; other site
574093004568	substrate-cofactor binding pocket; other site
574093004569	pyridoxal 5'-phosphate binding site [chemical binding]; other site
574093004570	catalytic residue [active]
574093004571	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
574093004572	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
574093004573	Walker A/P-loop; other site
574093004574	ATP binding site [chemical binding]; other site
574093004575	Q-loop/lid; other site
574093004576	ABC transporter signature motif; other site
574093004577	Walker B; other site
574093004578	D-loop; other site
574093004579	H-loop/switch region; other site
574093004580	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
574093004581	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
574093004582	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
574093004583	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
574093004584	peptide binding site [polypeptide binding]; other site
574093004585	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
574093004586	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
574093004587	UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022
574093004588	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
574093004589	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
574093004590	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
574093004591	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
574093004592	Domain of unknown function (DUF1803); Region: DUF1803; pfam08820
574093004593	Domain of unknown function (DUF1803); Region: DUF1803; pfam08820
574093004594	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
574093004595	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
574093004596	DHH family; Region: DHH; pfam01368
574093004597	DHHA2 domain; Region: DHHA2; pfam02833
574093004598	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
574093004599	GIY-YIG motif/motif A; other site
574093004600	putative active site [active]
574093004601	putative metal binding site [ion binding]; other site
574093004602	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
574093004603	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
574093004604	S-adenosylmethionine binding site [chemical binding]; other site
574093004605	hypothetical protein; Provisional; Region: PRK07252
574093004606	Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098
574093004607	RNA binding site [nucleotide binding]; other site
574093004608	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
574093004609	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
574093004610	active site
574093004611	motif I; other site
574093004612	motif II; other site
574093004613	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
574093004614	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
574093004615	active site
574093004616	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
574093004617	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
574093004618	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
574093004619	dimer interface [polypeptide binding]; other site
574093004620	ssDNA binding site [nucleotide binding]; other site
574093004621	tetramer (dimer of dimers) interface [polypeptide binding]; other site
574093004622	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
574093004623	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
574093004624	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
574093004625	putative dimer interface [polypeptide binding]; other site
574093004626	putative anticodon binding site; other site
574093004627	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
574093004628	homodimer interface [polypeptide binding]; other site
574093004629	motif 1; other site
574093004630	motif 2; other site
574093004631	active site
574093004632	motif 3; other site
574093004633	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
574093004634	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
574093004635	aspartate aminotransferase; Provisional; Region: PRK05764
574093004636	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
574093004637	pyridoxal 5'-phosphate binding site [chemical binding]; other site
574093004638	homodimer interface [polypeptide binding]; other site
574093004639	catalytic residue [active]
574093004640	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353
574093004641	Predicted flavoprotein [General function prediction only]; Region: COG0431
574093004642	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
574093004643	hypothetical protein; Validated; Region: PRK02101
574093004644	Protein of unknown function (DUF3953); Region: DUF3953; pfam13129
574093004645	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
574093004646	active site
574093004647	catalytic residues [active]
574093004648	metal binding site [ion binding]; metal-binding site
574093004649	putative S-transferase; Provisional; Region: PRK11752
574093004650	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
574093004651	C-terminal domain interface [polypeptide binding]; other site
574093004652	GSH binding site (G-site) [chemical binding]; other site
574093004653	dimer interface [polypeptide binding]; other site
574093004654	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
574093004655	N-terminal domain interface [polypeptide binding]; other site
574093004656	dimer interface [polypeptide binding]; other site
574093004657	substrate binding pocket (H-site) [chemical binding]; other site
574093004658	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
574093004659	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
574093004660	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
574093004661	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
574093004662	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
574093004663	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
574093004664	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
574093004665	Cation efflux family; Region: Cation_efflux; pfam01545
574093004666	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994
574093004667	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
574093004668	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
574093004669	Walker A/P-loop; other site
574093004670	ATP binding site [chemical binding]; other site
574093004671	Q-loop/lid; other site
574093004672	ABC transporter signature motif; other site
574093004673	Walker B; other site
574093004674	D-loop; other site
574093004675	H-loop/switch region; other site
574093004676	ABC transporter; Region: ABC_tran_2; pfam12848
574093004677	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
574093004678	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
574093004679	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
574093004680	active site
574093004681	NTP binding site [chemical binding]; other site
574093004682	metal binding triad [ion binding]; metal-binding site
574093004683	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
574093004684	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
574093004685	dihydrodipicolinate reductase; Provisional; Region: PRK00048
574093004686	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
574093004687	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
574093004688	EDD domain protein, DegV family; Region: DegV; TIGR00762
574093004689	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
574093004690	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4835
574093004691	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
574093004692	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
574093004693	active site
574093004694	substrate binding site [chemical binding]; other site
574093004695	metal binding site [ion binding]; metal-binding site
574093004696	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
574093004697	YbbR-like protein; Region: YbbR; pfam07949
574093004698	Uncharacterized conserved protein [Function unknown]; Region: COG1624
574093004699	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
574093004700	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
574093004701	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
574093004702	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
574093004703	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
574093004704	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
574093004705	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
574093004706	Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044
574093004707	dimer interface [polypeptide binding]; other site
574093004708	phosphate binding site [ion binding]; other site
574093004709	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
574093004710	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
574093004711	homotrimer interaction site [polypeptide binding]; other site
574093004712	putative active site [active]
574093004713	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
574093004714	G1 box; other site
574093004715	GTP/Mg2+ binding site [chemical binding]; other site
574093004716	Switch I region; other site
574093004717	G2 box; other site
574093004718	G3 box; other site
574093004719	Switch II region; other site
574093004720	G4 box; other site
574093004721	G5 box; other site
574093004722	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
574093004723	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
574093004724	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
574093004725	Walker A motif; other site
574093004726	ATP binding site [chemical binding]; other site
574093004727	Walker B motif; other site
574093004728	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
574093004729	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
574093004730	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
574093004731	folate binding site [chemical binding]; other site
574093004732	NADP+ binding site [chemical binding]; other site
574093004733	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
574093004734	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
574093004735	dimerization interface [polypeptide binding]; other site
574093004736	DPS ferroxidase diiron center [ion binding]; other site
574093004737	ion pore; other site
574093004738	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
574093004739	The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains.   LytC is composed of a...; Region: GH25_LytC-like; cd06414
574093004740	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
574093004741	active site
574093004742	triosephosphate isomerase; Provisional; Region: PRK14567
574093004743	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
574093004744	substrate binding site [chemical binding]; other site
574093004745	dimer interface [polypeptide binding]; other site
574093004746	catalytic triad [active]
574093004747	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
574093004748	DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446
574093004749	Homoserine trans-succinylase [Amino acid transport and metabolism]; Region: MetA; COG1897
574093004750	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
574093004751	proposed active site lysine [active]
574093004752	conserved cys residue [active]
574093004753	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
574093004754	active site
574093004755	Methyltransferase domain; Region: Methyltransf_31; pfam13847
574093004756	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
574093004757	S-adenosylmethionine binding site [chemical binding]; other site
574093004758	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
574093004759	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
574093004760	Walker A/P-loop; other site
574093004761	ATP binding site [chemical binding]; other site
574093004762	Q-loop/lid; other site
574093004763	ABC transporter signature motif; other site
574093004764	Walker B; other site
574093004765	D-loop; other site
574093004766	H-loop/switch region; other site
574093004767	TOBE domain; Region: TOBE_2; pfam08402
574093004768	Isochorismatase family; Region: Isochorismatase; pfam00857
574093004769	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
574093004770	catalytic triad [active]
574093004771	conserved cis-peptide bond; other site
574093004772	Pleiotropic transcriptional repressor [Transcription]; Region: CodY; COG4465
574093004773	CodY GAF-like domain; Region: CodY; pfam06018
574093004774	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
574093004775	putative DNA binding site [nucleotide binding]; other site
574093004776	putative Zn2+ binding site [ion binding]; other site
574093004777	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
574093004778	Helix-turn-helix domain; Region: HTH_38; pfam13936
574093004779	Integrase core domain; Region: rve; pfam00665
574093004780	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
574093004781	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
574093004782	ATP binding site [chemical binding]; other site
574093004783	Mg++ binding site [ion binding]; other site
574093004784	motif III; other site
574093004785	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
574093004786	nucleotide binding region [chemical binding]; other site
574093004787	ATP-binding site [chemical binding]; other site
574093004788	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
574093004789	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
574093004790	putative substrate translocation pore; other site
574093004791	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251
574093004792	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
574093004793	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
574093004794	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
574093004795	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
574093004796	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
574093004797	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
574093004798	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
574093004799	catalytic triad [active]
574093004800	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
574093004801	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
574093004802	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
574093004803	active site
574093004804	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
574093004805	HTH-like domain; Region: HTH_21; pfam13276
574093004806	Integrase core domain; Region: rve; pfam00665
574093004807	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
574093004808	Helix-turn-helix domain; Region: HTH_28; pfam13518
574093004809	Predicted membrane protein [Function unknown]; Region: COG4720
574093004810	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
574093004811	dimer interface [polypeptide binding]; other site
574093004812	substrate binding site [chemical binding]; other site
574093004813	ATP binding site [chemical binding]; other site
574093004814	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
574093004815	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
574093004816	dimerization interface 3.5A [polypeptide binding]; other site
574093004817	active site
574093004818	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
574093004819	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
574093004820	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
574093004821	PhnA protein; Region: PhnA; pfam03831
574093004822	cytidylate kinase; Provisional; Region: cmk; PRK00023
574093004823	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
574093004824	CMP-binding site; other site
574093004825	The sites determining sugar specificity; other site
574093004826	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
574093004827	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
574093004828	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
574093004829	Ligand binding site; other site
574093004830	Putative Catalytic site; other site
574093004831	DXD motif; other site
574093004832	UDP-glucose 4-epimerase; Region: PLN02240
574093004833	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
574093004834	NAD binding site [chemical binding]; other site
574093004835	homodimer interface [polypeptide binding]; other site
574093004836	active site
574093004837	substrate binding site [chemical binding]; other site
574093004838	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
574093004839	Uncharacterized conserved protein [Function unknown]; Region: COG0327
574093004840	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
574093004841	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
574093004842	Family of unknown function (DUF633); Region: DUF633; pfam04816
574093004843	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
574093004844	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
574093004845	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
574093004846	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
574093004847	motif II; other site
574093004848	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
574093004849	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
574093004850	putative acyl-acceptor binding pocket; other site
574093004851	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
574093004852	Cadmium resistance transporter; Region: Cad; pfam03596
574093004853	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
574093004854	16S/18S rRNA binding site [nucleotide binding]; other site
574093004855	S13e-L30e interaction site [polypeptide binding]; other site
574093004856	25S rRNA binding site [nucleotide binding]; other site
574093004857	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
574093004858	NADH(P)-binding; Region: NAD_binding_10; pfam13460
574093004859	NAD binding site [chemical binding]; other site
574093004860	substrate binding site [chemical binding]; other site
574093004861	putative active site [active]
574093004862	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
574093004863	metal binding site [ion binding]; metal-binding site
574093004864	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
574093004865	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
574093004866	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
574093004867	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
574093004868	active site
574093004869	dimer interface [polypeptide binding]; other site
574093004870	motif 1; other site
574093004871	motif 2; other site
574093004872	motif 3; other site
574093004873	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
574093004874	anticodon binding site; other site
574093004875	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
574093004876	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
574093004877	ATP binding site [chemical binding]; other site
574093004878	Mg2+ binding site [ion binding]; other site
574093004879	G-X-G motif; other site
574093004880	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
574093004881	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
574093004882	active site
574093004883	phosphorylation site [posttranslational modification]
574093004884	intermolecular recognition site; other site
574093004885	dimerization interface [polypeptide binding]; other site
574093004886	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
574093004887	DNA binding site [nucleotide binding]
574093004888	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741
574093004889	nucleophilic elbow; other site
574093004890	catalytic triad; other site
574093004891	Predicted transcriptional regulator [Transcription]; Region: COG1959
574093004892	Transcriptional regulator; Region: Rrf2; pfam02082
574093004893	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
574093004894	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
574093004895	active site
574093004896	metal binding site [ion binding]; metal-binding site
574093004897	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
574093004898	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
574093004899	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
574093004900	FeoA domain; Region: FeoA; pfam04023
574093004901	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
574093004902	putative active site [active]
574093004903	dimerization interface [polypeptide binding]; other site
574093004904	putative tRNAtyr binding site [nucleotide binding]; other site
574093004905	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
574093004906	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
574093004907	Zn2+ binding site [ion binding]; other site
574093004908	Mg2+ binding site [ion binding]; other site
574093004909	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
574093004910	synthetase active site [active]
574093004911	NTP binding site [chemical binding]; other site
574093004912	metal binding site [ion binding]; metal-binding site
574093004913	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
574093004914	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
574093004915	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
574093004916	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
574093004917	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
574093004918	active site
574093004919	Zn binding site [ion binding]; other site
574093004920	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
574093004921	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
574093004922	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
574093004923	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
574093004924	ABC-ATPase subunit  interface; other site
574093004925	dimer interface [polypeptide binding]; other site
574093004926	putative PBP binding regions; other site
574093004927	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
574093004928	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
574093004929	metal binding site [ion binding]; metal-binding site
574093004930	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
574093004931	dimer interface [polypeptide binding]; other site
574093004932	catalytic triad [active]
574093004933	peroxidatic and resolving cysteines [active]
574093004934	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
574093004935	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
574093004936	FtsX-like permease family; Region: FtsX; pfam02687
574093004937	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
574093004938	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
574093004939	Walker A/P-loop; other site
574093004940	ATP binding site [chemical binding]; other site
574093004941	Q-loop/lid; other site
574093004942	ABC transporter signature motif; other site
574093004943	Walker B; other site
574093004944	D-loop; other site
574093004945	H-loop/switch region; other site
574093004946	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
574093004947	catalytic core [active]
574093004948	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
574093004949	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
574093004950	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
574093004951	active site
574093004952	HIGH motif; other site
574093004953	nucleotide binding site [chemical binding]; other site
574093004954	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
574093004955	active site
574093004956	KMSKS motif; other site
574093004957	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
574093004958	tRNA binding surface [nucleotide binding]; other site
574093004959	anticodon binding site; other site
574093004960	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
574093004961	DivIVA domain; Region: DivI1A_domain; TIGR03544
574093004962	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
574093004963	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
574093004964	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
574093004965	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
574093004966	RNA binding surface [nucleotide binding]; other site
574093004967	YGGT family; Region: YGGT; pfam02325
574093004968	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
574093004969	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
574093004970	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
574093004971	catalytic residue [active]
574093004972	cell division protein FtsZ; Validated; Region: PRK09330
574093004973	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
574093004974	nucleotide binding site [chemical binding]; other site
574093004975	SulA interaction site; other site
574093004976	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
574093004977	Cell division protein FtsA; Region: FtsA; smart00842
574093004978	Cell division protein FtsA; Region: FtsA; pfam14450
574093004979	Domain of unknown function (DUF3484); Region: DUF3484; pfam11983
574093004980	Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529
574093004981	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
574093004982	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
574093004983	nudix motif; other site
574093004984	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
574093004985	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
574093004986	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
574093004987	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
574093004988	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
574093004989	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
574093004990	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
574093004991	recombination protein RecR; Reviewed; Region: recR; PRK00076
574093004992	RecR protein; Region: RecR; pfam02132
574093004993	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
574093004994	putative active site [active]
574093004995	putative metal-binding site [ion binding]; other site
574093004996	tetramer interface [polypeptide binding]; other site
574093004997	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
574093004998	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
574093004999	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
574093005000	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
574093005001	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
574093005002	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
574093005003	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
574093005004	putative active site [active]
574093005005	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
574093005006	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
574093005007	nucleotide binding site [chemical binding]; other site
574093005008	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
574093005009	Class I aldolases; Region: Aldolase_Class_I; cl17187
574093005010	catalytic residue [active]
574093005011	Protein of unknown function, DUF624; Region: DUF624; pfam04854
574093005012	Domain of unknown function (DUF386); Region: DUF386; pfam04074
574093005013	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
574093005014	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
574093005015	dimer interface [polypeptide binding]; other site
574093005016	conserved gate region; other site
574093005017	putative PBP binding loops; other site
574093005018	ABC-ATPase subunit interface; other site
574093005019	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
574093005020	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
574093005021	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
574093005022	putative PBP binding loops; other site
574093005023	dimer interface [polypeptide binding]; other site
574093005024	ABC-ATPase subunit interface; other site
574093005025	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
574093005026	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
574093005027	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
574093005028	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
574093005029	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
574093005030	active site turn [active]
574093005031	phosphorylation site [posttranslational modification]
574093005032	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
574093005033	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
574093005034	putative active site cavity [active]
574093005035	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
574093005036	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
574093005037	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
574093005038	Neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: NanH; COG4409
574093005039	Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated...; Region: PTX; cl00102
574093005040	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
574093005041	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
574093005042	Asp-box motif; other site
574093005043	catalytic site [active]
574093005044	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
574093005045	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
574093005046	DDE superfamily endonuclease; Region: DDE_4; cl17710
574093005047	Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated...; Region: PTX; cl00102
574093005048	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
574093005049	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
574093005050	dimer interface [polypeptide binding]; other site
574093005051	conserved gate region; other site
574093005052	putative PBP binding loops; other site
574093005053	ABC-ATPase subunit interface; other site
574093005054	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
574093005055	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
574093005056	dimer interface [polypeptide binding]; other site
574093005057	conserved gate region; other site
574093005058	putative PBP binding loops; other site
574093005059	ABC-ATPase subunit interface; other site
574093005060	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
574093005061	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
574093005062	uncharacterized protein, YhcH/YjgK/YiaL family; Region: TIGR00022
574093005063	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
574093005064	Sialidase, N-terminal domain; Region: Sialidase; pfam02973
574093005065	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
574093005066	catalytic site [active]
574093005067	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
574093005068	Asp-box motif; other site
574093005069	Asp-box motif; other site
574093005070	catalytic site [active]
574093005071	Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448
574093005072	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
574093005073	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
574093005074	ssDNA binding site; other site
574093005075	generic binding surface II; other site
574093005076	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
574093005077	ATP binding site [chemical binding]; other site
574093005078	putative Mg++ binding site [ion binding]; other site
574093005079	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
574093005080	nucleotide binding region [chemical binding]; other site
574093005081	ATP-binding site [chemical binding]; other site
574093005082	alanine racemase; Reviewed; Region: alr; PRK00053
574093005083	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
574093005084	active site
574093005085	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
574093005086	dimer interface [polypeptide binding]; other site
574093005087	substrate binding site [chemical binding]; other site
574093005088	catalytic residues [active]
574093005089	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
574093005090	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG0722
574093005091	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
574093005092	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG0722
574093005093	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
574093005094	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
574093005095	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
574093005096	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
574093005097	nucleotide binding region [chemical binding]; other site
574093005098	ATP-binding site [chemical binding]; other site
574093005099	SEC-C motif; Region: SEC-C; pfam02810
574093005100	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
574093005101	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
574093005102	Walker A/P-loop; other site
574093005103	ATP binding site [chemical binding]; other site
574093005104	Q-loop/lid; other site
574093005105	ABC transporter signature motif; other site
574093005106	Walker B; other site
574093005107	D-loop; other site
574093005108	H-loop/switch region; other site
574093005109	GTP-binding protein Der; Reviewed; Region: PRK00093
574093005110	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
574093005111	G1 box; other site
574093005112	GTP/Mg2+ binding site [chemical binding]; other site
574093005113	Switch I region; other site
574093005114	G2 box; other site
574093005115	Switch II region; other site
574093005116	G3 box; other site
574093005117	G4 box; other site
574093005118	G5 box; other site
574093005119	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
574093005120	G1 box; other site
574093005121	GTP/Mg2+ binding site [chemical binding]; other site
574093005122	Switch I region; other site
574093005123	G2 box; other site
574093005124	G3 box; other site
574093005125	Switch II region; other site
574093005126	G4 box; other site
574093005127	G5 box; other site
574093005128	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
574093005129	dimer interface [polypeptide binding]; other site
574093005130	FMN binding site [chemical binding]; other site
574093005131	NADPH bind site [chemical binding]; other site
574093005132	primosomal protein DnaI; Reviewed; Region: PRK08939
574093005133	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
574093005134	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
574093005135	Walker A motif; other site
574093005136	ATP binding site [chemical binding]; other site
574093005137	Walker B motif; other site
574093005138	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
574093005139	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
574093005140	ATP cone domain; Region: ATP-cone; pfam03477
574093005141	Predicted transcriptional regulators [Transcription]; Region: COG1725
574093005142	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
574093005143	DNA-binding site [nucleotide binding]; DNA binding site
574093005144	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
574093005145	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
574093005146	Walker A/P-loop; other site
574093005147	ATP binding site [chemical binding]; other site
574093005148	Q-loop/lid; other site
574093005149	ABC transporter signature motif; other site
574093005150	Walker B; other site
574093005151	D-loop; other site
574093005152	H-loop/switch region; other site
574093005153	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
574093005154	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
574093005155	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
574093005156	Walker A/P-loop; other site
574093005157	ATP binding site [chemical binding]; other site
574093005158	Q-loop/lid; other site
574093005159	ABC transporter signature motif; other site
574093005160	Walker B; other site
574093005161	D-loop; other site
574093005162	H-loop/switch region; other site
574093005163	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
574093005164	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
574093005165	Uncharacterized conserved protein [Function unknown]; Region: COG0398
574093005166	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
574093005167	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
574093005168	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
574093005169	nucleotide binding site [chemical binding]; other site
574093005170	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
574093005171	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
574093005172	active site turn [active]
574093005173	phosphorylation site [posttranslational modification]
574093005174	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
574093005175	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
574093005176	HPr interaction site; other site
574093005177	glycerol kinase (GK) interaction site [polypeptide binding]; other site
574093005178	active site
574093005179	phosphorylation site [posttranslational modification]
574093005180	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
574093005181	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
574093005182	substrate binding [chemical binding]; other site
574093005183	active site
574093005184	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
574093005185	Transcriptional regulators [Transcription]; Region: PurR; COG1609
574093005186	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
574093005187	DNA binding site [nucleotide binding]
574093005188	domain linker motif; other site
574093005189	Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291
574093005190	dimerization interface [polypeptide binding]; other site
574093005191	ligand binding site [chemical binding]; other site
574093005192	sodium binding site [ion binding]; other site
574093005193	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
574093005194	homodimer interface [polypeptide binding]; other site
574093005195	catalytic residues [active]
574093005196	NAD binding site [chemical binding]; other site
574093005197	substrate binding pocket [chemical binding]; other site
574093005198	flexible flap; other site
574093005199	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
574093005200	3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835
574093005201	dimer interface [polypeptide binding]; other site
574093005202	active site
574093005203	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
574093005204	Uncharacterized conserved protein [Function unknown]; Region: COG3610
574093005205	Uncharacterized conserved protein [Function unknown]; Region: COG2966
574093005206	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
574093005207	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
574093005208	Catalytic domain of Protein Kinases; Region: PKc; cd00180
574093005209	active site
574093005210	ATP binding site [chemical binding]; other site
574093005211	substrate binding site [chemical binding]; other site
574093005212	activation loop (A-loop); other site
574093005213	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
574093005214	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
574093005215	PASTA domain; Region: PASTA; smart00740
574093005216	PASTA domain; Region: PASTA; smart00740
574093005217	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
574093005218	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
574093005219	active site
574093005220	16S rRNA methyltransferase B; Provisional; Region: PRK14902
574093005221	NusB family; Region: NusB; pfam01029
574093005222	putative RNA binding site [nucleotide binding]; other site
574093005223	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
574093005224	S-adenosylmethionine binding site [chemical binding]; other site
574093005225	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
574093005226	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
574093005227	putative active site [active]
574093005228	substrate binding site [chemical binding]; other site
574093005229	putative cosubstrate binding site; other site
574093005230	catalytic site [active]
574093005231	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
574093005232	substrate binding site [chemical binding]; other site
574093005233	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
574093005234	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
574093005235	ATP binding site [chemical binding]; other site
574093005236	putative Mg++ binding site [ion binding]; other site
574093005237	helicase superfamily c-terminal domain; Region: HELICc; smart00490
574093005238	ATP-binding site [chemical binding]; other site
574093005239	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
574093005240	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
574093005241	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
574093005242	catalytic site [active]
574093005243	G-X2-G-X-G-K; other site
574093005244	hypothetical protein; Provisional; Region: PRK00106
574093005245	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
574093005246	Zn2+ binding site [ion binding]; other site
574093005247	Mg2+ binding site [ion binding]; other site
574093005248	Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769
574093005249	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
574093005250	hypothetical protein; Provisional; Region: PRK13670
574093005251	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636
574093005252	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
574093005253	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
574093005254	S-adenosylmethionine binding site [chemical binding]; other site
574093005255	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
574093005256	Isochorismatase family; Region: Isochorismatase; pfam00857
574093005257	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
574093005258	catalytic triad [active]
574093005259	conserved cis-peptide bond; other site
574093005260	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
574093005261	Zn2+ binding site [ion binding]; other site
574093005262	Mg2+ binding site [ion binding]; other site
574093005263	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
574093005264	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
574093005265	active site
574093005266	(T/H)XGH motif; other site
574093005267	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
574093005268	GTPase YqeH; Provisional; Region: PRK13796
574093005269	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
574093005270	GTP/Mg2+ binding site [chemical binding]; other site
574093005271	G4 box; other site
574093005272	G5 box; other site
574093005273	G1 box; other site
574093005274	Switch I region; other site
574093005275	G2 box; other site
574093005276	G3 box; other site
574093005277	Switch II region; other site
574093005278	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
574093005279	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
574093005280	active site
574093005281	motif I; other site
574093005282	motif II; other site
574093005283	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
574093005284	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
574093005285	Cl binding site [ion binding]; other site
574093005286	oligomer interface [polypeptide binding]; other site
574093005287	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
574093005288	Mechanosensitive ion channel; Region: MS_channel; pfam00924
574093005289	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
574093005290	serine/threonine transporter SstT; Provisional; Region: PRK14695
574093005291	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
574093005292	Predicted membrane protein [Function unknown]; Region: COG4129
574093005293	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
574093005294	DUF939 C-terminal domain; Region: DUF939_C; pfam11728
574093005295	MarR family; Region: MarR; pfam01047
574093005296	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
574093005297	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
574093005298	catalytic residues [active]
574093005299	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
574093005300	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
574093005301	amphipathic channel; other site
574093005302	Asn-Pro-Ala signature motifs; other site
574093005303	Protein of unknown function (DUF2785); Region: DUF2785; pfam10978
574093005304	ABC-2 type transporter; Region: ABC2_membrane; cl17235
574093005305	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
574093005306	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
574093005307	Walker A/P-loop; other site
574093005308	ATP binding site [chemical binding]; other site
574093005309	Q-loop/lid; other site
574093005310	ABC transporter signature motif; other site
574093005311	Walker B; other site
574093005312	D-loop; other site
574093005313	H-loop/switch region; other site
574093005314	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
574093005315	dimerization interface [polypeptide binding]; other site
574093005316	putative DNA binding site [nucleotide binding]; other site
574093005317	putative Zn2+ binding site [ion binding]; other site
574093005318	oligoendopeptidase F; Region: pepF; TIGR00181
574093005319	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
574093005320	Zn binding site [ion binding]; other site
574093005321	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
574093005322	RNA methyltransferase, RsmE family; Region: TIGR00046
574093005323	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
574093005324	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
574093005325	S-adenosylmethionine binding site [chemical binding]; other site
574093005326	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682
574093005327	nudix motif; other site
574093005328	Peptidase family M50; Region: Peptidase_M50; pfam02163
574093005329	Protein of unknown function (DUF3013); Region: DUF3013; pfam11217
574093005330	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
574093005331	YcfA-like protein; Region: YcfA; pfam07927
574093005332	recombination factor protein RarA; Reviewed; Region: PRK13342
574093005333	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
574093005334	Walker A motif; other site
574093005335	ATP binding site [chemical binding]; other site
574093005336	Walker B motif; other site
574093005337	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
574093005338	arginine finger; other site
574093005339	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
574093005340	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
574093005341	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
574093005342	substrate binding [chemical binding]; other site
574093005343	active site
574093005344	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
574093005345	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
574093005346	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
574093005347	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
574093005348	dimer interface [polypeptide binding]; other site
574093005349	conserved gate region; other site
574093005350	ABC-ATPase subunit interface; other site
574093005351	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
574093005352	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
574093005353	dimer interface [polypeptide binding]; other site
574093005354	conserved gate region; other site
574093005355	putative PBP binding loops; other site
574093005356	ABC-ATPase subunit interface; other site
574093005357	Transcriptional regulators [Transcription]; Region: PurR; COG1609
574093005358	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
574093005359	DNA binding site [nucleotide binding]
574093005360	domain linker motif; other site
574093005361	Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291
574093005362	dimerization interface [polypeptide binding]; other site
574093005363	ligand binding site [chemical binding]; other site
574093005364	sodium binding site [ion binding]; other site
574093005365	M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280
574093005366	Mga helix-turn-helix domain; Region: Mga; pfam05043
574093005367	M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270
574093005368	Predicted membrane protein [Function unknown]; Region: COG2261
574093005369	Small integral membrane protein [Function unknown]; Region: COG5547
574093005370	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
574093005371	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
574093005372	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
574093005373	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
574093005374	Uncharacterized conserved protein [Function unknown]; Region: COG1262
574093005375	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
574093005376	arylsulfatase; Provisional; Region: PRK13759
574093005377	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
574093005378	potential frameshift: common BLAST hit: gi|221232545|ref|YP_002511699.1| sugar phosphotransferase system (PTS), IIC component
574093005379	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
574093005380	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
574093005381	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
574093005382	active site
574093005383	methionine cluster; other site
574093005384	phosphorylation site [posttranslational modification]
574093005385	metal binding site [ion binding]; metal-binding site
574093005386	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
574093005387	active site
574093005388	P-loop; other site
574093005389	phosphorylation site [posttranslational modification]
574093005390	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
574093005391	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
574093005392	MarR family; Region: MarR_2; pfam12802
574093005393	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
574093005394	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
574093005395	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
574093005396	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
574093005397	Coenzyme A binding pocket [chemical binding]; other site
574093005398	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
574093005399	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
574093005400	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
574093005401	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
574093005402	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
574093005403	non-specific DNA binding site [nucleotide binding]; other site
574093005404	salt bridge; other site
574093005405	sequence-specific DNA binding site [nucleotide binding]; other site
574093005406	Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856
574093005407	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
574093005408	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
574093005409	substrate binding site [chemical binding]; other site
574093005410	active site
574093005411	catalytic residues [active]
574093005412	heterodimer interface [polypeptide binding]; other site
574093005413	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
574093005414	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
574093005415	pyridoxal 5'-phosphate binding site [chemical binding]; other site
574093005416	catalytic residue [active]
574093005417	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
574093005418	active site
574093005419	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
574093005420	active site
574093005421	ribulose/triose binding site [chemical binding]; other site
574093005422	phosphate binding site [ion binding]; other site
574093005423	substrate (anthranilate) binding pocket [chemical binding]; other site
574093005424	product (indole) binding pocket [chemical binding]; other site
574093005425	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
574093005426	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
574093005427	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
574093005428	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
574093005429	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
574093005430	glutamine binding [chemical binding]; other site
574093005431	catalytic triad [active]
574093005432	anthranilate synthase component I; Provisional; Region: PRK13570
574093005433	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
574093005434	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
574093005435	Transcriptional regulators [Transcription]; Region: PurR; COG1609
574093005436	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
574093005437	DNA binding site [nucleotide binding]
574093005438	domain linker motif; other site
574093005439	Ligand-binding domain of a transcription repressor, FucR, which functions as a molecular sensor of L-fucose availability; Region: PBP1_FucR_like; cd06276
574093005440	putative dimerization interface [polypeptide binding]; other site
574093005441	putative ligand binding site [chemical binding]; other site
574093005442	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
574093005443	MgtC family; Region: MgtC; pfam02308
574093005444	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
574093005445	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
574093005446	dimer interface [polypeptide binding]; other site
574093005447	conserved gate region; other site
574093005448	putative PBP binding loops; other site
574093005449	ABC-ATPase subunit interface; other site
574093005450	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
574093005451	putative PBP binding loops; other site
574093005452	dimer interface [polypeptide binding]; other site
574093005453	ABC-ATPase subunit interface; other site
574093005454	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
574093005455	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
574093005456	Walker A/P-loop; other site
574093005457	ATP binding site [chemical binding]; other site
574093005458	Q-loop/lid; other site
574093005459	ABC transporter signature motif; other site
574093005460	Walker B; other site
574093005461	D-loop; other site
574093005462	H-loop/switch region; other site
574093005463	TOBE domain; Region: TOBE; pfam03459
574093005464	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
574093005465	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
574093005466	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5255
574093005467	Domain of unknown function (DUF1868); Region: 2H-phosphodiest; pfam08975
574093005468	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
574093005469	UDP-glucose 4-epimerase; Region: PLN02240
574093005470	NAD binding site [chemical binding]; other site
574093005471	homodimer interface [polypeptide binding]; other site
574093005472	active site
574093005473	substrate binding site [chemical binding]; other site
574093005474	Galactose-1-phosphate uridyltransferase [Carbohydrate transport and metabolism]; Region: GalT; COG4468
574093005475	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
574093005476	Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744
574093005477	Phosphate uptake regulator [Inorganic ion transport and metabolism]; Region: PhoU; COG0704
574093005478	PhoU domain; Region: PhoU; pfam01895
574093005479	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
574093005480	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
574093005481	Pectate lyase; Region: Pec_lyase_C; cl01593
574093005482	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
574093005483	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
574093005484	inhibitor-cofactor binding pocket; inhibition site
574093005485	pyridoxal 5'-phosphate binding site [chemical binding]; other site
574093005486	catalytic residue [active]
574093005487	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
574093005488	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
574093005489	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
574093005490	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
574093005491	Walker A/P-loop; other site
574093005492	ATP binding site [chemical binding]; other site
574093005493	Q-loop/lid; other site
574093005494	ABC transporter signature motif; other site
574093005495	Walker B; other site
574093005496	D-loop; other site
574093005497	H-loop/switch region; other site
574093005498	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
574093005499	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
574093005500	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
574093005501	Walker A/P-loop; other site
574093005502	ATP binding site [chemical binding]; other site
574093005503	Q-loop/lid; other site
574093005504	ABC transporter signature motif; other site
574093005505	Walker B; other site
574093005506	D-loop; other site
574093005507	H-loop/switch region; other site
574093005508	Predicted membrane protein [Function unknown]; Region: COG2323
574093005509	Protein of unknown function (DUF3290); Region: DUF3290; pfam11694
574093005510	Protein of unknown function (DUF3290); Region: DUF3290; pfam11694
574093005511	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
574093005512	active site
574093005513	putative catalytic site [active]
574093005514	DNA binding site [nucleotide binding]
574093005515	putative phosphate binding site [ion binding]; other site
574093005516	metal binding site A [ion binding]; metal-binding site
574093005517	AP binding site [nucleotide binding]; other site
574093005518	metal binding site B [ion binding]; metal-binding site
574093005519	Bleomycin binding protein (BLMA) and similar proteins; BLMA confers bleomycin (Bm) resistance by directly binding to Bm; Region: BLMA_like; cd08349
574093005520	dimer interface [polypeptide binding]; other site
574093005521	ligand binding site [chemical binding]; other site
574093005522	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
574093005523	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
574093005524	active site
574093005525	xanthine permease; Region: pbuX; TIGR03173
574093005526	Sulfate transporter family; Region: Sulfate_transp; pfam00916
574093005527	DpnII restriction endonuclease; Region: DpnII; pfam04556
574093005528	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
574093005529	DNA methylase; Region: N6_N4_Mtase; pfam01555
574093005530	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
574093005531	S-adenosylmethionine binding site [chemical binding]; other site
574093005532	DNA adenine methylase (dam); Region: dam; TIGR00571
574093005533	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
574093005534	CoenzymeA binding site [chemical binding]; other site
574093005535	subunit interaction site [polypeptide binding]; other site
574093005536	PHB binding site; other site
574093005537	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270
574093005538	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
574093005539	Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744
574093005540	galactokinase; Provisional; Region: PRK05322
574093005541	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
574093005542	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
574093005543	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
574093005544	DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339
574093005545	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
574093005546	DNA binding site [nucleotide binding]
574093005547	Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544
574093005548	putative dimerization interface [polypeptide binding]; other site
574093005549	putative ligand binding site [chemical binding]; other site
574093005550	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287
574093005551	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
574093005552	catalytic Zn binding site [ion binding]; other site
574093005553	NAD(P) binding site [chemical binding]; other site
574093005554	structural Zn binding site [ion binding]; other site
574093005555	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
574093005556	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
574093005557	DNA binding residues [nucleotide binding]
574093005558	putative dimer interface [polypeptide binding]; other site
574093005559	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
574093005560	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
574093005561	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
574093005562	Utp21 specific WD40 associated putative domain; Region: Utp21; pfam04192
574093005563	nicotinamide mononucleotide transporter PnuC; Region: NMN_trans_PnuC; TIGR01528
574093005564	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
574093005565	dimer interface [polypeptide binding]; other site
574093005566	conserved gate region; other site
574093005567	ABC-ATPase subunit interface; other site
574093005568	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
574093005569	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
574093005570	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
574093005571	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
574093005572	Walker A/P-loop; other site
574093005573	ATP binding site [chemical binding]; other site
574093005574	Q-loop/lid; other site
574093005575	ABC transporter signature motif; other site
574093005576	Walker B; other site
574093005577	D-loop; other site
574093005578	H-loop/switch region; other site
574093005579	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
574093005580	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
574093005581	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
574093005582	Enterocin A Immunity; Region: EntA_Immun; pfam08951
574093005583	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
574093005584	M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638
574093005585	oligomer interface [polypeptide binding]; other site
574093005586	active site
574093005587	metal binding site [ion binding]; metal-binding site
574093005588	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
574093005589	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
574093005590	NAD(P) binding site [chemical binding]; other site
574093005591	active site
574093005592	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
574093005593	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
574093005594	ABC-ATPase subunit  interface; other site
574093005595	dimer interface [polypeptide binding]; other site
574093005596	putative PBP binding regions; other site
574093005597	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
574093005598	ABC-ATPase subunit  interface; other site
574093005599	dimer interface [polypeptide binding]; other site
574093005600	putative PBP binding regions; other site
574093005601	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
574093005602	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
574093005603	Walker A/P-loop; other site
574093005604	ATP binding site [chemical binding]; other site
574093005605	Q-loop/lid; other site
574093005606	ABC transporter signature motif; other site
574093005607	Walker B; other site
574093005608	D-loop; other site
574093005609	H-loop/switch region; other site
574093005610	ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607
574093005611	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
574093005612	putative ligand binding residues [chemical binding]; other site
574093005613	hypothetical protein; Validated; Region: PRK00041
574093005614	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
574093005615	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
574093005616	RNA binding surface [nucleotide binding]; other site
574093005617	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
574093005618	active site
574093005619	segregation and condensation protein B; Reviewed; Region: scpB; PRK00135
574093005620	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
574093005621	site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436
574093005622	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
574093005623	active site
574093005624	Int/Topo IB signature motif; other site
574093005625	DNA binding site [nucleotide binding]
574093005626	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643
574093005627	FOG: CBS domain [General function prediction only]; Region: COG0517
574093005628	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
574093005629	active site
574093005630	metal binding site [ion binding]; metal-binding site
574093005631	homotetramer interface [polypeptide binding]; other site
574093005632	putative deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein; Reviewed; Region: PRK02491
574093005633	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
574093005634	active site
574093005635	dimerization interface [polypeptide binding]; other site
574093005636	glutamate racemase; Provisional; Region: PRK00865
574093005637	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763
574093005638	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
574093005639	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
574093005640	Ca binding site [ion binding]; other site
574093005641	active site
574093005642	catalytic site [active]
574093005643	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
574093005644	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
574093005645	active site turn [active]
574093005646	phosphorylation site [posttranslational modification]
574093005647	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
574093005648	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
574093005649	HPr interaction site; other site
574093005650	glycerol kinase (GK) interaction site [polypeptide binding]; other site
574093005651	active site
574093005652	phosphorylation site [posttranslational modification]
574093005653	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
574093005654	DNA-binding site [nucleotide binding]; DNA binding site
574093005655	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
574093005656	UTRA domain; Region: UTRA; pfam07702
574093005657	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
574093005658	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
574093005659	Walker A/P-loop; other site
574093005660	ATP binding site [chemical binding]; other site
574093005661	Q-loop/lid; other site
574093005662	ABC transporter signature motif; other site
574093005663	Walker B; other site
574093005664	D-loop; other site
574093005665	H-loop/switch region; other site
574093005666	potential frameshift: common BLAST hit: gi|225855320|ref|YP_002736832.1| ABC transporter permease protein
574093005667	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
574093005668	TM-ABC transporter signature motif; other site
574093005669	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454
574093005670	potential frameshift: common BLAST hit: gi|289167199|ref|YP_003445466.1| ABC transporter, substrate binding protein
574093005671	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
574093005672	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
574093005673	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
574093005674	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
574093005675	Walker A/P-loop; other site
574093005676	ATP binding site [chemical binding]; other site
574093005677	Q-loop/lid; other site
574093005678	ABC transporter signature motif; other site
574093005679	Walker B; other site
574093005680	D-loop; other site
574093005681	H-loop/switch region; other site
574093005682	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
574093005683	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
574093005684	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
574093005685	Walker A/P-loop; other site
574093005686	ATP binding site [chemical binding]; other site
574093005687	Q-loop/lid; other site
574093005688	ABC transporter signature motif; other site
574093005689	Walker B; other site
574093005690	D-loop; other site
574093005691	H-loop/switch region; other site
574093005692	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
574093005693	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
574093005694	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
574093005695	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
574093005696	dimer interface [polypeptide binding]; other site
574093005697	conserved gate region; other site
574093005698	putative PBP binding loops; other site
574093005699	ABC-ATPase subunit interface; other site
574093005700	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
574093005701	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
574093005702	dimer interface [polypeptide binding]; other site
574093005703	conserved gate region; other site
574093005704	putative PBP binding loops; other site
574093005705	ABC-ATPase subunit interface; other site
574093005706	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
574093005707	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
574093005708	peptide binding site [polypeptide binding]; other site
574093005709	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
574093005710	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
574093005711	sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852
574093005712	Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355
574093005713	active site
574093005714	homodimer interface [polypeptide binding]; other site
574093005715	catalytic site [active]
574093005716	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
574093005717	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
574093005718	dimer interface [polypeptide binding]; other site
574093005719	conserved gate region; other site
574093005720	putative PBP binding loops; other site
574093005721	ABC-ATPase subunit interface; other site
574093005722	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
574093005723	dimer interface [polypeptide binding]; other site
574093005724	conserved gate region; other site
574093005725	putative PBP binding loops; other site
574093005726	ABC-ATPase subunit interface; other site
574093005727	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
574093005728	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
574093005729	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
574093005730	Melibiase; Region: Melibiase; pfam02065
574093005731	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
574093005732	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
574093005733	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
574093005734	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
574093005735	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
574093005736	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
574093005737	DNA-binding site [nucleotide binding]; DNA binding site
574093005738	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
574093005739	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
574093005740	TRAM domain; Region: TRAM; pfam01938
574093005741	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
574093005742	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
574093005743	S-adenosylmethionine binding site [chemical binding]; other site
574093005744	recombination regulator RecX; Provisional; Region: recX; PRK14135
574093005745	hypothetical protein; Provisional; Region: PRK13662
574093005746	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
574093005747	Methyltransferase domain; Region: Methyltransf_31; pfam13847
574093005748	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
574093005749	S-adenosylmethionine binding site [chemical binding]; other site
574093005750	Uncharacterized BCR, COG1636; Region: DUF208; cl17782
574093005751	Uncharacterized BCR, COG1636; Region: DUF208; cl17782
574093005752	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
574093005753	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
574093005754	ring oligomerisation interface [polypeptide binding]; other site
574093005755	ATP/Mg binding site [chemical binding]; other site
574093005756	stacking interactions; other site
574093005757	hinge regions; other site
574093005758	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
574093005759	oligomerisation interface [polypeptide binding]; other site
574093005760	mobile loop; other site
574093005761	roof hairpin; other site
574093005762	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
574093005763	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
574093005764	dimer interface [polypeptide binding]; other site
574093005765	ssDNA binding site [nucleotide binding]; other site
574093005766	tetramer (dimer of dimers) interface [polypeptide binding]; other site
574093005767	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
574093005768	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
574093005769	putative NAD(P) binding site [chemical binding]; other site
574093005770	homodimer interface [polypeptide binding]; other site
574093005771	homotetramer interface [polypeptide binding]; other site
574093005772	active site
574093005773	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
574093005774	putative tRNA-binding site [nucleotide binding]; other site
574093005775	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
574093005776	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
574093005777	catalytic residues [active]
574093005778	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
574093005779	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
574093005780	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
574093005781	LytTr DNA-binding domain; Region: LytTR; pfam04397
574093005782	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
574093005783	active site
574093005784	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
574093005785	Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; cl02047
574093005786	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
574093005787	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
574093005788	Walker A/P-loop; other site
574093005789	ATP binding site [chemical binding]; other site
574093005790	Q-loop/lid; other site
574093005791	ABC transporter signature motif; other site
574093005792	Walker B; other site
574093005793	D-loop; other site
574093005794	H-loop/switch region; other site
574093005795	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
574093005796	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
574093005797	MarR family; Region: MarR_2; pfam12802
574093005798	Transcriptional regulators [Transcription]; Region: MarR; COG1846
574093005799	hypothetical protein; Provisional; Region: PRK12378
574093005800	Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289
574093005801	Protein of unknown function (DUF4231); Region: DUF4231; pfam14015
574093005802	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
574093005803	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
574093005804	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
574093005805	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
574093005806	non-specific DNA binding site [nucleotide binding]; other site
574093005807	salt bridge; other site
574093005808	sequence-specific DNA binding site [nucleotide binding]; other site
574093005809	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
574093005810	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
574093005811	amidase catalytic site [active]
574093005812	Zn binding residues [ion binding]; other site
574093005813	substrate binding site [chemical binding]; other site
574093005814	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
574093005815	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
574093005816	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
574093005817	recombinase A; Provisional; Region: recA; PRK09354
574093005818	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
574093005819	hexamer interface [polypeptide binding]; other site
574093005820	Walker A motif; other site
574093005821	ATP binding site [chemical binding]; other site
574093005822	Walker B motif; other site
574093005823	competence damage-inducible protein A; Provisional; Region: PRK00549
574093005824	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
574093005825	putative MPT binding site; other site
574093005826	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
574093005827	Transcriptional regulator [Transcription]; Region: LytR; COG1316
574093005828	putative acetyltransferase YhhY; Provisional; Region: PRK10140
574093005829	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
574093005830	Coenzyme A binding pocket [chemical binding]; other site
574093005831	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
574093005832	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
574093005833	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
574093005834	non-specific DNA binding site [nucleotide binding]; other site
574093005835	salt bridge; other site
574093005836	sequence-specific DNA binding site [nucleotide binding]; other site
574093005837	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652
574093005838	Protein of unknown function (DUF1430); Region: DUF1430; pfam07242
574093005839	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
574093005840	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
574093005841	Walker A/P-loop; other site
574093005842	ATP binding site [chemical binding]; other site
574093005843	Q-loop/lid; other site
574093005844	ABC transporter signature motif; other site
574093005845	Walker B; other site
574093005846	D-loop; other site
574093005847	H-loop/switch region; other site
574093005848	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
574093005849	active site
574093005850	multimer interface [polypeptide binding]; other site
574093005851	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
574093005852	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
574093005853	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
574093005854	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
574093005855	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
574093005856	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
574093005857	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
574093005858	G-loop; other site
574093005859	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
574093005860	DNA binding site [nucleotide binding]
574093005861	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
574093005862	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
574093005863	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
574093005864	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
574093005865	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
574093005866	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
574093005867	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
574093005868	RPB1 interaction site [polypeptide binding]; other site
574093005869	RPB10 interaction site [polypeptide binding]; other site
574093005870	RPB11 interaction site [polypeptide binding]; other site
574093005871	RPB3 interaction site [polypeptide binding]; other site
574093005872	RPB12 interaction site [polypeptide binding]; other site
574093005873	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
574093005874	Domain of unknown function DUF21; Region: DUF21; pfam01595
574093005875	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
574093005876	Transporter associated domain; Region: CorC_HlyC; smart01091
574093005877	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
574093005878	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; pfam01223
574093005879	DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772
574093005880	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
574093005881	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
574093005882	hinge; other site
574093005883	active site
574093005884	Protein of unknown function (DUF1146); Region: DUF1146; pfam06612
574093005885	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
574093005886	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
574093005887	protein binding site [polypeptide binding]; other site
574093005888	potential frameshift: common BLAST hit: gi|225857542|ref|YP_002739053.1| phosphopantetheine adenylyltransferase
574093005889	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
574093005890	active site
574093005891	KMSKS motif; other site
574093005892	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
574093005893	active site
574093005894	HIGH motif; other site
574093005895	nucleotide binding site [chemical binding]; other site
574093005896	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
574093005897	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
574093005898	S-adenosylmethionine binding site [chemical binding]; other site
574093005899	Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia.  AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645
574093005900	dimer interface [polypeptide binding]; other site
574093005901	active site
574093005902	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
574093005903	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
574093005904	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
574093005905	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
574093005906	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
574093005907	acylphosphatase; Provisional; Region: PRK14434
574093005908	OxaA-like protein precursor; Provisional; Region: PRK02463
574093005909	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
574093005910	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
574093005911	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
574093005912	FeS/SAM binding site; other site
574093005913	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
574093005914	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
574093005915	active site
574093005916	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
574093005917	substrate binding site [chemical binding]; other site
574093005918	catalytic residues [active]
574093005919	dimer interface [polypeptide binding]; other site
574093005920	pur operon repressor; Provisional; Region: PRK09213
574093005921	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
574093005922	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
574093005923	active site
574093005924	Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481
574093005925	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
574093005926	generic binding surface II; other site
574093005927	generic binding surface I; other site
574093005928	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
574093005929	Zn2+ binding site [ion binding]; other site
574093005930	Mg2+ binding site [ion binding]; other site
574093005931	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
574093005932	RmuC family; Region: RmuC; pfam02646
574093005933	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
574093005934	Thiamine pyrophosphokinase; Region: TPK; cd07995
574093005935	active site
574093005936	dimerization interface [polypeptide binding]; other site
574093005937	thiamine binding site [chemical binding]; other site
574093005938	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
574093005939	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
574093005940	substrate binding site [chemical binding]; other site
574093005941	hexamer interface [polypeptide binding]; other site
574093005942	metal binding site [ion binding]; metal-binding site
574093005943	GTPase RsgA; Reviewed; Region: PRK00098
574093005944	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
574093005945	RNA binding site [nucleotide binding]; other site
574093005946	homodimer interface [polypeptide binding]; other site
574093005947	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
574093005948	GTPase/Zn-binding domain interface [polypeptide binding]; other site
574093005949	GTP/Mg2+ binding site [chemical binding]; other site
574093005950	G4 box; other site
574093005951	G5 box; other site
574093005952	G1 box; other site
574093005953	Switch I region; other site
574093005954	G2 box; other site
574093005955	G3 box; other site
574093005956	Switch II region; other site
574093005957	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
574093005958	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
574093005959	S-adenosylmethionine binding site [chemical binding]; other site
574093005960	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
574093005961	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
574093005962	Walker A/P-loop; other site
574093005963	ATP binding site [chemical binding]; other site
574093005964	Q-loop/lid; other site
574093005965	ABC transporter signature motif; other site
574093005966	Walker B; other site
574093005967	D-loop; other site
574093005968	H-loop/switch region; other site
574093005969	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652
574093005970	Protein of unknown function (DUF1430); Region: DUF1430; pfam07242
574093005971	Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891
574093005972	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
574093005973	DDE superfamily endonuclease; Region: DDE_4; cl17710
574093005974	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
574093005975	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
574093005976	non-specific DNA binding site [nucleotide binding]; other site
574093005977	salt bridge; other site
574093005978	sequence-specific DNA binding site [nucleotide binding]; other site
574093005979	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
574093005980	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
574093005981	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
574093005982	putative active site [active]
574093005983	putative metal binding site [ion binding]; other site
574093005984	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
574093005985	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
574093005986	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
574093005987	active site
574093005988	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
574093005989	Ribosomal protein L34; Region: Ribosomal_L34; cl00370
574093005990	aminotransferase AlaT; Validated; Region: PRK09265
574093005991	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
574093005992	pyridoxal 5'-phosphate binding site [chemical binding]; other site
574093005993	homodimer interface [polypeptide binding]; other site
574093005994	catalytic residue [active]
574093005995	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
574093005996	Ligand Binding Site [chemical binding]; other site
574093005997	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
574093005998	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
574093005999	active site
574093006000	motif I; other site
574093006001	motif II; other site
574093006002	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
574093006003	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545
574093006004	putative nucleotide binding site [chemical binding]; other site
574093006005	putative metal binding site [ion binding]; other site
574093006006	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
574093006007	active site
574093006008	homotetramer interface [polypeptide binding]; other site
574093006009	homodimer interface [polypeptide binding]; other site
574093006010	catabolite control protein A; Region: ccpA; TIGR01481
574093006011	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
574093006012	DNA binding site [nucleotide binding]
574093006013	domain linker motif; other site
574093006014	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
574093006015	dimerization interface [polypeptide binding]; other site
574093006016	effector binding site; other site
574093006017	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
574093006018	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
574093006019	active site
574093006020	phosphorylation site [posttranslational modification]
574093006021	intermolecular recognition site; other site
574093006022	dimerization interface [polypeptide binding]; other site
574093006023	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
574093006024	DNA binding residues [nucleotide binding]
574093006025	dimerization interface [polypeptide binding]; other site
574093006026	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
574093006027	Histidine kinase; Region: HisKA_3; pfam07730
574093006028	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
574093006029	ATP binding site [chemical binding]; other site
574093006030	Mg2+ binding site [ion binding]; other site
574093006031	G-X-G motif; other site
574093006032	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
574093006033	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
574093006034	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
574093006035	Walker A/P-loop; other site
574093006036	ATP binding site [chemical binding]; other site
574093006037	Q-loop/lid; other site
574093006038	ABC transporter signature motif; other site
574093006039	Walker B; other site
574093006040	D-loop; other site
574093006041	H-loop/switch region; other site
574093006042	potential frameshift: common BLAST hit: gi|182684008|ref|YP_001835755.1| IS1239 transposase
574093006043	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
574093006044	Integrase core domain; Region: rve; pfam00665
574093006045	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
574093006046	Helix-turn-helix domain; Region: HTH_38; pfam13936
574093006047	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
574093006048	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
574093006049	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
574093006050	putative homodimer interface [polypeptide binding]; other site
574093006051	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
574093006052	heterodimer interface [polypeptide binding]; other site
574093006053	homodimer interface [polypeptide binding]; other site
574093006054	Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690
574093006055	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
574093006056	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
574093006057	Transglycosylase; Region: Transgly; pfam00912
574093006058	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
574093006059	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
574093006060	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
574093006061	active site
574093006062	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
574093006063	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
574093006064	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
574093006065	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
574093006066	FtsX-like permease family; Region: FtsX; pfam02687
574093006067	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
574093006068	DDE superfamily endonuclease; Region: DDE_3; pfam13358
574093006069	Transposase; Region: HTH_Tnp_IS630; pfam01710
574093006070	Helix-turn-helix domain; Region: HTH_28; pfam13518
574093006071	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06559
574093006072	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
574093006073	dimerization interface [polypeptide binding]; other site
574093006074	active site
574093006075	Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158
574093006076	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
574093006077	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
574093006078	Walker A/P-loop; other site
574093006079	ATP binding site [chemical binding]; other site
574093006080	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
574093006081	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
574093006082	DNA-binding site [nucleotide binding]; DNA binding site
574093006083	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
574093006084	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
574093006085	beta-galactosidase; Region: BGL; TIGR03356
574093006086	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
574093006087	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
574093006088	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
574093006089	active site
574093006090	P-loop; other site
574093006091	phosphorylation site [posttranslational modification]
574093006092	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
574093006093	methionine cluster; other site
574093006094	active site
574093006095	phosphorylation site [posttranslational modification]
574093006096	metal binding site [ion binding]; metal-binding site
574093006097	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
574093006098	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
574093006099	putative catalytic cysteine [active]
574093006100	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
574093006101	putative active site [active]
574093006102	metal binding site [ion binding]; metal-binding site
574093006103	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
574093006104	MORN repeat; Region: MORN; cl14787
574093006105	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
574093006106	Low molecular weight phosphatase family; Region: LMWPc; cd00115
574093006107	active site
574093006108	preprotein translocase subunit YajC; Validated; Region: yajC; PRK06531
574093006109	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
574093006110	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
574093006111	TPP-binding site [chemical binding]; other site
574093006112	dimer interface [polypeptide binding]; other site
574093006113	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
574093006114	PYR/PP interface [polypeptide binding]; other site
574093006115	dimer interface [polypeptide binding]; other site
574093006116	TPP binding site [chemical binding]; other site
574093006117	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
574093006118	putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709
574093006119	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
574093006120	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
574093006121	PRD domain; Region: PRD; pfam00874
574093006122	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
574093006123	active site
574093006124	P-loop; other site
574093006125	phosphorylation site [posttranslational modification]
574093006126	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
574093006127	L-ribulose-5-phosphate 4-epimerase; Provisional; Region: araD; PRK13145
574093006128	intersubunit interface [polypeptide binding]; other site
574093006129	active site
574093006130	Zn2+ binding site [ion binding]; other site
574093006131	putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210
574093006132	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
574093006133	AP (apurinic/apyrimidinic) site pocket; other site
574093006134	DNA interaction; other site
574093006135	Metal-binding active site; metal-binding site
574093006136	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
574093006137	active site
574093006138	dimer interface [polypeptide binding]; other site
574093006139	magnesium binding site [ion binding]; other site
574093006140	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
574093006141	active site
574093006142	phosphorylation site [posttranslational modification]
574093006143	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
574093006144	active site
574093006145	P-loop; other site
574093006146	phosphorylation site [posttranslational modification]
574093006147	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997
574093006148	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
574093006149	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
574093006150	G-X-X-G motif; other site
574093006151	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
574093006152	RxxxH motif; other site
574093006153	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
574093006154	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
574093006155	ribonuclease P; Reviewed; Region: rnpA; PRK00499
574093006156	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
574093006157	propionate/acetate kinase; Provisional; Region: PRK12379
574093006158	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
574093006159	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
574093006160	S-adenosylmethionine binding site [chemical binding]; other site
574093006161	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
574093006162	Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940
574093006163	Type II secretory pathway pseudopilin; Region: PulG; pfam11773
574093006164	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
574093006165	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
574093006166	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
574093006167	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
574093006168	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
574093006169	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
574093006170	Walker A motif; other site
574093006171	ATP binding site [chemical binding]; other site
574093006172	Walker B motif; other site
574093006173	Protein of unknown function (DUF1033); Region: DUF1033; pfam06279
574093006174	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286
574093006175	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
574093006176	catalytic Zn binding site [ion binding]; other site
574093006177	structural Zn binding site [ion binding]; other site
574093006178	NAD(P) binding site [chemical binding]; other site
574093006179	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
574093006180	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
574093006181	active site
574093006182	dimer interface [polypeptide binding]; other site
574093006183	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
574093006184	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
574093006185	catalytic triad [active]
574093006186	catalytic triad [active]
574093006187	oxyanion hole [active]
574093006188	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
574093006189	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
574093006190	Predicted integral membrane protein [Function unknown]; Region: COG5523
574093006191	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
574093006192	putative substrate binding pocket [chemical binding]; other site
574093006193	AC domain interface; other site
574093006194	catalytic triad [active]
574093006195	AB domain interface; other site
574093006196	interchain disulfide; other site
574093006197	Predicted membrane protein [Function unknown]; Region: COG3759
574093006198	Transcriptional regulators [Transcription]; Region: MarR; COG1846
574093006199	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
574093006200	putative DNA binding site [nucleotide binding]; other site
574093006201	putative Zn2+ binding site [ion binding]; other site
574093006202	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
574093006203	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
574093006204	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
574093006205	motif II; other site
574093006206	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
574093006207	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
574093006208	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
574093006209	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
574093006210	pyridoxal 5'-phosphate binding site [chemical binding]; other site
574093006211	catalytic residue [active]
574093006212	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
574093006213	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
574093006214	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
574093006215	DDE superfamily endonuclease; Region: DDE_4; cl17710
574093006216	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
574093006217	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
574093006218	active site
574093006219	catalytic motif [active]
574093006220	Zn binding site [ion binding]; other site
574093006221	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
574093006222	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
574093006223	active site
574093006224	HIGH motif; other site
574093006225	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
574093006226	active site
574093006227	KMSKS motif; other site
574093006228	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
574093006229	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
574093006230	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
574093006231	active site
574093006232	dimer interface [polypeptide binding]; other site
574093006233	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
574093006234	dimer interface [polypeptide binding]; other site
574093006235	active site
574093006236	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
574093006237	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
574093006238	catalytic triad [active]
574093006239	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
574093006240	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
574093006241	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
574093006242	Walker A/P-loop; other site
574093006243	ATP binding site [chemical binding]; other site
574093006244	Q-loop/lid; other site
574093006245	ABC transporter signature motif; other site
574093006246	Walker B; other site
574093006247	D-loop; other site
574093006248	H-loop/switch region; other site
574093006249	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
574093006250	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
574093006251	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
574093006252	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
574093006253	Walker A/P-loop; other site
574093006254	ATP binding site [chemical binding]; other site
574093006255	Q-loop/lid; other site
574093006256	ABC transporter signature motif; other site
574093006257	Walker B; other site
574093006258	D-loop; other site
574093006259	H-loop/switch region; other site
574093006260	DNA mismatch repair protein MutS; Region: mutS1; TIGR01070
574093006261	MutS domain I; Region: MutS_I; pfam01624
574093006262	MutS domain II; Region: MutS_II; pfam05188
574093006263	MutS domain III; Region: MutS_III; pfam05192
574093006264	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
574093006265	Walker A/P-loop; other site
574093006266	ATP binding site [chemical binding]; other site
574093006267	Q-loop/lid; other site
574093006268	ABC transporter signature motif; other site
574093006269	Walker B; other site
574093006270	D-loop; other site
574093006271	H-loop/switch region; other site
574093006272	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
574093006273	arginine repressor; Region: argR_whole; TIGR01529
574093006274	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
574093006275	arginyl-tRNA synthetase; Reviewed; Region: PRK12451
574093006276	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
574093006277	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
574093006278	active site
574093006279	HIGH motif; other site
574093006280	KMSK motif region; other site
574093006281	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
574093006282	tRNA binding surface [nucleotide binding]; other site
574093006283	anticodon binding site; other site
574093006284	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
574093006285	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
574093006286	Uncharacterized conserved protein [Function unknown]; Region: COG3542
574093006287	potential frameshift: common BLAST hit: gi|298501581|ref|YP_003723521.1| response regulator
574093006288	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
574093006289	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
574093006290	active site
574093006291	phosphorylation site [posttranslational modification]
574093006292	intermolecular recognition site; other site
574093006293	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
574093006294	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
574093006295	dimerization interface [polypeptide binding]; other site
574093006296	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
574093006297	DNA binding site [nucleotide binding]
574093006298	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
574093006299	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
574093006300	dimer interface [polypeptide binding]; other site
574093006301	phosphorylation site [posttranslational modification]
574093006302	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
574093006303	ATP binding site [chemical binding]; other site
574093006304	G-X-G motif; other site
574093006305	PBP superfamily domain; Region: PBP_like_2; cl17296
574093006306	PBP superfamily domain; Region: PBP_like_2; cl17296
574093006307	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
574093006308	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
574093006309	dimer interface [polypeptide binding]; other site
574093006310	conserved gate region; other site
574093006311	putative PBP binding loops; other site
574093006312	ABC-ATPase subunit interface; other site
574093006313	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
574093006314	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
574093006315	dimer interface [polypeptide binding]; other site
574093006316	conserved gate region; other site
574093006317	putative PBP binding loops; other site
574093006318	ABC-ATPase subunit interface; other site
574093006319	phosphate transporter ATP-binding protein; Provisional; Region: PRK14240
574093006320	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
574093006321	Walker A/P-loop; other site
574093006322	ATP binding site [chemical binding]; other site
574093006323	Q-loop/lid; other site
574093006324	ABC transporter signature motif; other site
574093006325	Walker B; other site
574093006326	D-loop; other site
574093006327	H-loop/switch region; other site
574093006328	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
574093006329	PhoU domain; Region: PhoU; pfam01895
574093006330	PhoU domain; Region: PhoU; pfam01895
574093006331	DNA replication terminus site-binding protein (Ter protein); Region: Ter; cl11502
574093006332	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
574093006333	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
574093006334	non-specific DNA binding site [nucleotide binding]; other site
574093006335	salt bridge; other site
574093006336	sequence-specific DNA binding site [nucleotide binding]; other site
574093006337	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
574093006338	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
574093006339	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
574093006340	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
574093006341	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
574093006342	active site
574093006343	tetramer interface; other site
574093006344	Rhomboid family; Region: Rhomboid; pfam01694
574093006345	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
574093006346	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
574093006347	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
574093006348	M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670
574093006349	metal binding site [ion binding]; metal-binding site
574093006350	putative dimer interface [polypeptide binding]; other site
574093006351	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
574093006352	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
574093006353	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
574093006354	trimer interface [polypeptide binding]; other site
574093006355	active site
574093006356	substrate binding site [chemical binding]; other site
574093006357	CoA binding site [chemical binding]; other site
574093006358	EamA-like transporter family; Region: EamA; pfam00892
574093006359	Transglycosylase; Region: Transgly; pfam00912
574093006360	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
574093006361	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
574093006362	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
574093006363	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
574093006364	active site
574093006365	HIGH motif; other site
574093006366	dimer interface [polypeptide binding]; other site
574093006367	KMSKS motif; other site
574093006368	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
574093006369	RNA binding surface [nucleotide binding]; other site
574093006370	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
574093006371	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
574093006372	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
574093006373	motif II; other site
574093006374	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
574093006375	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
574093006376	S-adenosylmethionine binding site [chemical binding]; other site
574093006377	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
574093006378	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
574093006379	4-alpha-glucanotransferase; Provisional; Region: PRK14508
574093006380	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
574093006381	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
574093006382	ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
574093006383	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
574093006384	conserved gate region; other site
574093006385	putative PBP binding loops; other site
574093006386	ABC-ATPase subunit interface; other site
574093006387	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
574093006388	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
574093006389	dimer interface [polypeptide binding]; other site
574093006390	conserved gate region; other site
574093006391	putative PBP binding loops; other site
574093006392	ABC-ATPase subunit interface; other site
574093006393	Predicted integral membrane protein [Function unknown]; Region: COG5521
574093006394	Transcriptional regulators [Transcription]; Region: PurR; COG1609
574093006395	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
574093006396	DNA binding site [nucleotide binding]
574093006397	domain linker motif; other site
574093006398	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
574093006399	putative dimerization interface [polypeptide binding]; other site
574093006400	putative ligand binding site [chemical binding]; other site
574093006401	Uncharacterized conserved protein [Function unknown]; Region: COG1284
574093006402	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
574093006403	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
574093006404	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
574093006405	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
574093006406	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
574093006407	dimer interface [polypeptide binding]; other site
574093006408	anticodon binding site; other site
574093006409	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
574093006410	homodimer interface [polypeptide binding]; other site
574093006411	motif 1; other site
574093006412	active site
574093006413	motif 2; other site
574093006414	GAD domain; Region: GAD; pfam02938
574093006415	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
574093006416	motif 3; other site
574093006417	CAAX protease self-immunity; Region: Abi; pfam02517
574093006418	Protein of unknown function (DUF3169); Region: DUF3169; pfam11368
574093006419	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
574093006420	non-specific DNA binding site [nucleotide binding]; other site
574093006421	salt bridge; other site
574093006422	sequence-specific DNA binding site [nucleotide binding]; other site
574093006423	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
574093006424	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
574093006425	dimer interface [polypeptide binding]; other site
574093006426	motif 1; other site
574093006427	active site
574093006428	motif 2; other site
574093006429	motif 3; other site
574093006430	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
574093006431	anticodon binding site; other site
574093006432	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
574093006433	non-specific DNA binding site [nucleotide binding]; other site
574093006434	salt bridge; other site
574093006435	sequence-specific DNA binding site [nucleotide binding]; other site
574093006436	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
574093006437	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
574093006438	6-phosphogluconate dehydratase; Region: edd; TIGR01196
574093006439	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
574093006440	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
574093006441	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
574093006442	PYR/PP interface [polypeptide binding]; other site
574093006443	dimer interface [polypeptide binding]; other site
574093006444	TPP binding site [chemical binding]; other site
574093006445	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
574093006446	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
574093006447	TPP-binding site [chemical binding]; other site
574093006448	dimer interface [polypeptide binding]; other site
574093006449	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
574093006450	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
574093006451	active site
574093006452	P-loop; other site
574093006453	phosphorylation site [posttranslational modification]
574093006454	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
574093006455	PRD domain; Region: PRD; pfam00874
574093006456	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
574093006457	active site
574093006458	P-loop; other site
574093006459	phosphorylation site [posttranslational modification]
574093006460	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
574093006461	active site
574093006462	phosphorylation site [posttranslational modification]
574093006463	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
574093006464	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_2; cd03402
574093006465	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877
574093006466	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
574093006467	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
574093006468	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
574093006469	Leucine rich repeat; Region: LRR_8; pfam13855
574093006470	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
574093006471	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
574093006472	Divergent AAA domain; Region: AAA_4; pfam04326
574093006473	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
574093006474	Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA  is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565
574093006475	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
574093006476	putative active site [active]
574093006477	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
574093006478	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
574093006479	nucleotide binding site [chemical binding]; other site
574093006480	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
574093006481	N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814
574093006482	active site
574093006483	metal binding site [ion binding]; metal-binding site
574093006484	homodimer interface [polypeptide binding]; other site
574093006485	catalytic site [active]
574093006486	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
574093006487	Uncharacterized conserved protein [Function unknown]; Region: COG3538
574093006488	Protein of unknown function (DUF1237); Region: DUF1237; pfam06824
574093006489	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
574093006490	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
574093006491	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
574093006492	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
574093006493	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
574093006494	arginine deiminase; Provisional; Region: PRK01388
574093006495	ornithine carbamoyltransferase; Validated; Region: PRK02102
574093006496	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
574093006497	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
574093006498	carbamate kinase; Reviewed; Region: PRK12686
574093006499	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
574093006500	putative substrate binding site [chemical binding]; other site
574093006501	nucleotide binding site [chemical binding]; other site
574093006502	nucleotide binding site [chemical binding]; other site
574093006503	homodimer interface [polypeptide binding]; other site
574093006504	Predicted membrane protein [Function unknown]; Region: COG1288
574093006505	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
574093006506	hypothetical protein; Provisional; Region: PRK07205
574093006507	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
574093006508	active site
574093006509	metal binding site [ion binding]; metal-binding site
574093006510	M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580
574093006511	M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580
574093006512	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
574093006513	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
574093006514	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_4; cd03407
574093006515	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
574093006516	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
574093006517	dimer interface [polypeptide binding]; other site
574093006518	active site
574093006519	metal binding site [ion binding]; metal-binding site
574093006520	L-fucose isomerase; Provisional; Region: fucI; PRK10991
574093006521	L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556
574093006522	hexamer (dimer of trimers) interface [polypeptide binding]; other site
574093006523	trimer interface [polypeptide binding]; other site
574093006524	substrate binding site [chemical binding]; other site
574093006525	Mn binding site [ion binding]; other site
574093006526	Glycosyl hydrolase family 98; Region: Glyco_hydro_98M; pfam08306
574093006527	Glycosyl hydrolase family 98 C-terminal domain; Region: Glyco_hydro_98C; pfam08307
574093006528	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
574093006529	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
574093006530	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
574093006531	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
574093006532	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
574093006533	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
574093006534	active site
574093006535	phosphorylation site [posttranslational modification]
574093006536	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
574093006537	active pocket/dimerization site; other site
574093006538	active site
574093006539	phosphorylation site [posttranslational modification]
574093006540	Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154
574093006541	L-fuculose phosphate aldolase; Provisional; Region: PRK06833
574093006542	intersubunit interface [polypeptide binding]; other site
574093006543	active site
574093006544	Zn2+ binding site [ion binding]; other site
574093006545	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
574093006546	N- and C-terminal domain interface [polypeptide binding]; other site
574093006547	rhamnulokinase; Region: rhamnulo_kin; TIGR02627
574093006548	active site
574093006549	putative catalytic site [active]
574093006550	metal binding site [ion binding]; metal-binding site
574093006551	ATP binding site [chemical binding]; other site
574093006552	carbohydrate binding site [chemical binding]; other site
574093006553	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
574093006554	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
574093006555	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
574093006556	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
574093006557	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
574093006558	metal binding site [ion binding]; metal-binding site
574093006559	YodA lipocalin-like domain; Region: YodA; pfam09223
574093006560	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
574093006561	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
574093006562	ABC-ATPase subunit  interface; other site
574093006563	dimer interface [polypeptide binding]; other site
574093006564	putative PBP binding regions; other site
574093006565	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
574093006566	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
574093006567	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
574093006568	putative DNA binding site [nucleotide binding]; other site
574093006569	potential frameshift: common BLAST hit: gi|225857741|ref|YP_002739252.1| D-alanine transfer from undecaprenol-phosphate to the poly
574093006570	DltD C-terminal region; Region: DltD_C; pfam04914
574093006571	DltD N-terminal region; Region: DltD_N; pfam04915
574093006572	DltD central region; Region: DltD_M; pfam04918
574093006573	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087
574093006574	D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091
574093006575	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
574093006576	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
574093006577	acyl-activating enzyme (AAE) consensus motif; other site
574093006578	AMP binding site [chemical binding]; other site
574093006579	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
574093006580	amphipathic channel; other site
574093006581	Asn-Pro-Ala signature motifs; other site
574093006582	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
574093006583	glycerol kinase; Provisional; Region: glpK; PRK00047
574093006584	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
574093006585	N- and C-terminal domain interface [polypeptide binding]; other site
574093006586	active site
574093006587	MgATP binding site [chemical binding]; other site
574093006588	catalytic site [active]
574093006589	metal binding site [ion binding]; metal-binding site
574093006590	glycerol binding site [chemical binding]; other site
574093006591	homotetramer interface [polypeptide binding]; other site
574093006592	homodimer interface [polypeptide binding]; other site
574093006593	FBP binding site [chemical binding]; other site
574093006594	protein IIAGlc interface [polypeptide binding]; other site
574093006595	Mga helix-turn-helix domain; Region: Mga; pfam05043
574093006596	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
574093006597	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
574093006598	dimerization interface [polypeptide binding]; other site
574093006599	domain crossover interface; other site
574093006600	redox-dependent activation switch; other site
574093006601	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
574093006602	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
574093006603	FMN binding site [chemical binding]; other site
574093006604	active site
574093006605	catalytic residues [active]
574093006606	substrate binding site [chemical binding]; other site
574093006607	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
574093006608	RICH domain; Region: RICH; pfam05062
574093006609	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
574093006610	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
574093006611	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
574093006612	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
574093006613	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
574093006614	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755
574093006615	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
574093006616	HAMP domain; Region: HAMP; pfam00672
574093006617	dimerization interface [polypeptide binding]; other site
574093006618	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
574093006619	dimer interface [polypeptide binding]; other site
574093006620	phosphorylation site [posttranslational modification]
574093006621	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
574093006622	ATP binding site [chemical binding]; other site
574093006623	Mg2+ binding site [ion binding]; other site
574093006624	G-X-G motif; other site
574093006625	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
574093006626	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
574093006627	active site
574093006628	phosphorylation site [posttranslational modification]
574093006629	intermolecular recognition site; other site
574093006630	dimerization interface [polypeptide binding]; other site
574093006631	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
574093006632	DNA binding site [nucleotide binding]
574093006633	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
574093006634	Clp amino terminal domain; Region: Clp_N; pfam02861
574093006635	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
574093006636	Walker A motif; other site
574093006637	ATP binding site [chemical binding]; other site
574093006638	Walker B motif; other site
574093006639	arginine finger; other site
574093006640	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
574093006641	Walker A motif; other site
574093006642	ATP binding site [chemical binding]; other site
574093006643	Walker B motif; other site
574093006644	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
574093006645	Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463
574093006646	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
574093006647	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
574093006648	Walker A/P-loop; other site
574093006649	ATP binding site [chemical binding]; other site
574093006650	Q-loop/lid; other site
574093006651	ABC transporter signature motif; other site
574093006652	Walker B; other site
574093006653	D-loop; other site
574093006654	H-loop/switch region; other site
574093006655	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
574093006656	NMT1/THI5 like; Region: NMT1; pfam09084
574093006657	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
574093006658	Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528
574093006659	Uncharacterized conserved protein [Function unknown]; Region: COG0011
574093006660	Surface antigen [General function prediction only]; Region: COG3942
574093006661	CHAP domain; Region: CHAP; pfam05257
574093006662	Bacterial SH3 domain; Region: SH3_5; pfam08460
574093006663	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
574093006664	Bacterial SH3 domain; Region: SH3_5; pfam08460
574093006665	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
574093006666	Uncharacterized protein conserved in bacteria [Function unknown]; Region: Veg; COG4466
574093006667	replicative DNA helicase; Provisional; Region: PRK05748
574093006668	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
574093006669	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
574093006670	Walker A motif; other site
574093006671	ATP binding site [chemical binding]; other site
574093006672	Walker B motif; other site
574093006673	DNA binding loops [nucleotide binding]
574093006674	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
574093006675	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
574093006676	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
574093006677	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
574093006678	DHH family; Region: DHH; pfam01368
574093006679	DHHA1 domain; Region: DHHA1; pfam02272
574093006680	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
574093006681	30S subunit binding site; other site
574093006682	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
574093006683	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
574093006684	active site
574093006685	Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098
574093006686	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
574093006687	ATP binding site [chemical binding]; other site
574093006688	putative Mg++ binding site [ion binding]; other site
574093006689	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
574093006690	nucleotide binding region [chemical binding]; other site
574093006691	ATP-binding site [chemical binding]; other site
574093006692	Uncharacterized conserved protein [Function unknown]; Region: COG1739
574093006693	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
574093006694	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
574093006695	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
574093006696	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
574093006697	dimer interface [polypeptide binding]; other site
574093006698	pyridoxal 5'-phosphate binding site [chemical binding]; other site
574093006699	catalytic residue [active]
574093006700	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
574093006701	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
574093006702	DDE superfamily endonuclease; Region: DDE_3; pfam13358
574093006703	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
574093006704	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
574093006705	elongation factor Ts; Provisional; Region: tsf; PRK09377
574093006706	UBA/TS-N domain; Region: UBA; pfam00627
574093006707	Elongation factor TS; Region: EF_TS; pfam00889
574093006708	Elongation factor TS; Region: EF_TS; pfam00889
574093006709	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
574093006710	rRNA interaction site [nucleotide binding]; other site
574093006711	S8 interaction site; other site
574093006712	putative laminin-1 binding site; other site
574093006713	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
574093006714	Septum formation initiator; Region: DivIC; cl17659
574093006715	Surface antigen [General function prediction only]; Region: COG3942
574093006716	CHAP domain; Region: CHAP; pfam05257
574093006717	rod shape-determining protein MreD; Region: MreD; cl01087
574093006718	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792
574093006719	rod shape-determining protein MreC; Region: MreC; pfam04085
574093006720	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
574093006721	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13649
574093006722	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
574093006723	Walker A/P-loop; other site
574093006724	ATP binding site [chemical binding]; other site
574093006725	Q-loop/lid; other site
574093006726	ABC transporter signature motif; other site
574093006727	Walker B; other site
574093006728	D-loop; other site
574093006729	H-loop/switch region; other site
574093006730	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13650
574093006731	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
574093006732	Walker A/P-loop; other site
574093006733	ATP binding site [chemical binding]; other site
574093006734	Q-loop/lid; other site
574093006735	ABC transporter signature motif; other site
574093006736	Walker B; other site
574093006737	D-loop; other site
574093006738	H-loop/switch region; other site
574093006739	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
574093006740	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
574093006741	Helix-turn-helix domain; Region: HTH_25; pfam13413
574093006742	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
574093006743	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
574093006744	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
574093006745	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
574093006746	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
574093006747	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
574093006748	S4-like RNA binding protein [Replication, recombination, and repair]; Region: COG2501
574093006749	Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195
574093006750	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
574093006751	Walker A/P-loop; other site
574093006752	ATP binding site [chemical binding]; other site
574093006753	Q-loop/lid; other site
574093006754	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
574093006755	ABC transporter signature motif; other site
574093006756	Walker B; other site
574093006757	D-loop; other site
574093006758	H-loop/switch region; other site
574093006759	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
574093006760	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
574093006761	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
574093006762	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
574093006763	active site
574093006764	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
574093006765	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
574093006766	active site
574093006767	HIGH motif; other site
574093006768	dimer interface [polypeptide binding]; other site
574093006769	KMSKS motif; other site
574093006770	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
574093006771	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
574093006772	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
574093006773	ABC transporter; Region: ABC_tran_2; pfam12848
574093006774	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
574093006775	Predicted membrane protein [Function unknown]; Region: COG4485
574093006776	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
574093006777	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
574093006778	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
574093006779	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
574093006780	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
574093006781	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
574093006782	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
574093006783	active site
574093006784	phosphorylation site [posttranslational modification]
574093006785	intermolecular recognition site; other site
574093006786	dimerization interface [polypeptide binding]; other site
574093006787	LytTr DNA-binding domain; Region: LytTR; pfam04397
574093006788	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
574093006789	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
574093006790	potential frameshift: common BLAST hit: gi|182684008|ref|YP_001835755.1| IS1239 transposase
574093006791	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
574093006792	Integrase core domain; Region: rve; pfam00665
574093006793	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
574093006794	Helix-turn-helix domain; Region: HTH_38; pfam13936
574093006795	COMC family; Region: ComC; pfam03047
574093006796	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
574093006797	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
574093006798	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
574093006799	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
574093006800	protein binding site [polypeptide binding]; other site
574093006801	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
574093006802	ParB-like nuclease domain; Region: ParBc; pfam02195
574093006803	KorB domain; Region: KorB; pfam08535