-- dump date 20140620_084416 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GI -- field 3 GeneID -- field 4 chrom_position -- field 5 chromosome -- field 6 codon_start -- field 7 contig -- field 8 description -- field 9 end_pos -- field 10 gene -- field 11 gene_id -- field 12 name -- field 13 organism -- field 14 product -- field 15 protein_id -- field 16 start_pos -- field 17 strand -- field 18 taxid -- field 19 type -- header -- id GI GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type YP_002510101.1 221230949 7329487 186..1547 1 NC_011900.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 1547 dnaA 7329487 dnaA Streptococcus pneumoniae ATCC 700669 chromosomal replication initiation protein YP_002510101.1 186 D 561276 CDS YP_002510102.1 221230950 7329237 1706..2842 1 NC_011900.1 binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 2842 dnaN 7329237 dnaN Streptococcus pneumoniae ATCC 700669 DNA polymerase III subunit beta YP_002510102.1 1706 D 561276 CDS YP_002510103.1 221230951 7329246 2907..3101 1 NC_011900.1 hypothetical protein 3101 7329246 SPN23F_00030 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510103.1 2907 D 561276 CDS YP_002510104.1 221230952 7329567 3185..4300 1 NC_011900.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 4300 7329567 SPN23F_00040 Streptococcus pneumoniae ATCC 700669 GTP-dependent nucleic acid-binding protein EngD YP_002510104.1 3185 D 561276 CDS YP_002510105.1 221230953 7329568 4372..4941 1 NC_011900.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 4941 pth 7329568 pth Streptococcus pneumoniae ATCC 700669 peptidyl-tRNA hydrolase YP_002510105.1 4372 D 561276 CDS YP_002510106.1 221230954 7327891 4942..8451 1 NC_011900.1 transcription-repair coupling factor 8451 trcF 7327891 trcF Streptococcus pneumoniae ATCC 700669 transcription-repair coupling factor YP_002510106.1 4942 D 561276 CDS YP_002510107.1 221230955 7327582 8509..8775 1 NC_011900.1 S4 domain containing protein 8775 7327582 SPN23F_00070 Streptococcus pneumoniae ATCC 700669 S4 domain containing protein YP_002510107.1 8509 D 561276 CDS YP_002510108.1 221230956 7329569 8768..9136 1 NC_011900.1 septum formation initiator protein 9136 7329569 SPN23F_00080 Streptococcus pneumoniae ATCC 700669 septum formation initiator protein YP_002510108.1 8768 D 561276 CDS YP_002510109.1 221230957 7329570 9141..9263 1 NC_011900.1 hypothetical protein 9263 7329570 SPN23F_00090 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510109.1 9141 D 561276 CDS YP_002510110.1 221230958 7329571 9256..10524 1 NC_011900.1 hypothetical protein 10524 7329571 SPN23F_00100 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510110.1 9256 D 561276 CDS YP_002510111.1 221230959 7329572 10521..11798 1 NC_011900.1 ATP-binding PP-loop family protein 11798 7329572 SPN23F_00110 Streptococcus pneumoniae ATCC 700669 ATP-binding PP-loop family protein YP_002510111.1 10521 D 561276 CDS YP_002510112.1 221230960 7329573 11802..12344 1 NC_011900.1 hypoxanthine-guanine phosphoribosyltransferase 12344 hpt 7329573 hpt Streptococcus pneumoniae ATCC 700669 hypoxanthine-guanine phosphoribosyltransferase YP_002510112.1 11802 D 561276 CDS YP_002510113.1 221230961 7328075 12360..14318 1 NC_011900.1 cell division protease FtsH 14318 ftsH 7328075 ftsH Streptococcus pneumoniae ATCC 700669 cell division protease FtsH YP_002510113.1 12360 D 561276 CDS YP_002510114.1 221230962 7328569 complement(14384..15640) 1 NC_011900.1 IS1167 transposase 15640 7328569 SPN23F_00140 Streptococcus pneumoniae ATCC 700669 IS1167 transposase YP_002510114.1 14384 R 561276 CDS YP_002510115.1 221230963 7329574 15863..16342 1 NC_011900.1 competence-specific global transcription modulator 16342 comX 7329574 comX Streptococcus pneumoniae ATCC 700669 competence-specific global transcription modulator YP_002510115.1 15863 D 561276 CDS YP_002510116.1 221230964 7329576 23778..24014 1 NC_011900.1 hypothetical protein 24014 7329576 SPN23F_00220 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510116.1 23778 D 561276 CDS YP_002510117.1 221230965 7329577 24245..25531 1 NC_011900.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 25531 purA 7329577 purA Streptococcus pneumoniae ATCC 700669 adenylosuccinate synthetase YP_002510117.1 24245 D 561276 CDS YP_002510118.1 221230966 7327896 25732..26199 1 NC_011900.1 deaminase 26199 7327896 SPN23F_00240 Streptococcus pneumoniae ATCC 700669 deaminase YP_002510118.1 25732 D 561276 CDS YP_002510119.1 221230967 7329579 complement(27604..28674) 1 NC_011900.1 type I restriction enzyme related protein 28674 7329579 SPN23F_00270 Streptococcus pneumoniae ATCC 700669 type I restriction enzyme related protein YP_002510119.1 27604 R 561276 CDS YP_002510120.1 221230968 7329580 complement(28691..29071) 1 NC_011900.1 hypothetical protein 29071 7329580 SPN23F_00280 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510120.1 28691 R 561276 CDS YP_002510121.1 221230969 7329581 complement(29084..29347) 1 NC_011900.1 plasmid stabilisation system protein 29347 7329581 SPN23F_00290 Streptococcus pneumoniae ATCC 700669 plasmid stabilisation system protein YP_002510121.1 29084 R 561276 CDS YP_002510122.1 221230970 7329582 complement(29347..29580) 1 NC_011900.1 hypothetical protein 29580 7329582 SPN23F_00300 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510122.1 29347 R 561276 CDS YP_002510123.1 221230971 7329583 complement(29580..29948) 1 NC_011900.1 phage DNA-binding protein 29948 7329583 SPN23F_00310 Streptococcus pneumoniae ATCC 700669 phage DNA-binding protein YP_002510123.1 29580 R 561276 CDS YP_002510124.1 221230972 7329584 30246..30377 1 NC_011900.1 hypothetical protein 30377 7329584 SPN23F_00320 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510124.1 30246 D 561276 CDS YP_002510125.1 221230973 7329585 30520..30711 1 NC_011900.1 DNA-binding protein 30711 7329585 SPN23F_00330 Streptococcus pneumoniae ATCC 700669 DNA-binding protein YP_002510125.1 30520 D 561276 CDS YP_002510126.1 221230974 7329586 30734..30937 1 NC_011900.1 hypothetical protein 30937 7329586 SPN23F_00340 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510126.1 30734 D 561276 CDS YP_002510127.1 221230975 7329587 complement(31092..31259) 1 NC_011900.1 hypothetical protein 31259 7329587 SPN23F_00350 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510127.1 31092 R 561276 CDS YP_002510128.1 221230976 7329590 complement(31864..32043) 1 NC_011900.1 hypothetical protein mw1055; DNA-binding protein 32043 7329590 SPN23F_00380 Streptococcus pneumoniae ATCC 700669 DNA-binding protein YP_002510128.1 31864 R 561276 CDS YP_002510129.1 221230977 7329591 32639..33082 1 NC_011900.1 catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 33082 dut 7329591 dut Streptococcus pneumoniae ATCC 700669 deoxyuridine 5'-triphosphate nucleotidohydrolase YP_002510129.1 32639 D 561276 CDS YP_002510130.1 221230978 7329592 33084..33599 1 NC_011900.1 phosphoglycerate mutase family protein 33599 7329592 SPN23F_00400 Streptococcus pneumoniae ATCC 700669 phosphoglycerate mutase family protein YP_002510130.1 33084 D 561276 CDS YP_002510131.1 221230979 7329593 33712..34974 1 NC_011900.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 34974 sms 7329593 sms Streptococcus pneumoniae ATCC 700669 DNA repair protein RadA YP_002510131.1 33712 D 561276 CDS YP_002510132.1 221230980 7329146 35047..35544 1 NC_011900.1 carbonic anhydrase 35544 7329146 SPN23F_00420 Streptococcus pneumoniae ATCC 700669 carbonic anhydrase YP_002510132.1 35047 D 561276 CDS YP_002510133.1 221230981 7329024 36497..37465 1 NC_011900.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 37465 prsA1 7329024 prsA1 Streptococcus pneumoniae ATCC 700669 ribose-phosphate pyrophosphokinase YP_002510133.1 36497 D 561276 CDS YP_002510134.1 221230982 7329026 39119..41752 1 NC_011900.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 41752 polA 7329026 polA Streptococcus pneumoniae ATCC 700669 DNA polymerase I YP_002510134.1 39119 D 561276 CDS YP_002510135.1 221230983 7327863 41837..42274 1 NC_011900.1 CoA-binding protein 42274 7327863 SPN23F_00500 Streptococcus pneumoniae ATCC 700669 CoA-binding protein YP_002510135.1 41837 D 561276 CDS YP_002510136.1 221230984 7329028 complement(42549..43559) 1 NC_011900.1 hypothetical protein 43559 7329028 SPN23F_00520 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510136.1 42549 R 561276 CDS YP_002510137.1 221230985 7329029 43708..44877 1 NC_011900.1 catalyzes the transamination of the aromatic amino acid forming a ketoacid; first step in aromatic amino acid degradation in lactococci; aromatic amino acid aminotransferase 44877 7329029 SPN23F_00530 Streptococcus pneumoniae ATCC 700669 aromatic amino acid aminotransferase YP_002510137.1 43708 D 561276 CDS YP_002510138.1 221230986 7329030 44874..45644 1 NC_011900.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO 45644 recO 7329030 recO Streptococcus pneumoniae ATCC 700669 DNA repair protein RecO YP_002510138.1 44874 D 561276 CDS YP_002510139.1 221230987 7327446 45641..46633 1 NC_011900.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; glycerol-3-phosphate acyltransferase PlsX 46633 plsX 7327446 plsX Streptococcus pneumoniae ATCC 700669 glycerol-3-phosphate acyltransferase PlsX YP_002510139.1 45641 D 561276 CDS YP_002510140.1 221230988 7327852 46639..46872 1 NC_011900.1 acyl carrier protein 46872 7327852 SPN23F_00560 Streptococcus pneumoniae ATCC 700669 acyl carrier protein YP_002510140.1 46639 D 561276 CDS YP_002510141.1 221230989 7329032 47411..47641 1 NC_011900.1 bacteriocin BlpO 47641 blpO 7329032 blpO Streptococcus pneumoniae ATCC 700669 bacteriocin BlpO YP_002510141.1 47411 D 561276 CDS YP_002510142.1 221230990 7328692 47644..47769 1 NC_011900.1 hypothetical protein 47769 7328692 SPN23F_00580 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510142.1 47644 D 561276 CDS YP_002510143.1 221230991 7329033 48356..50509 1 NC_011900.1 bacteriocin transport/processing ATP-binding protein 50509 7329033 SPN23F_00590 Streptococcus pneumoniae ATCC 700669 bacteriocin transport/processing ATP-binding protein YP_002510143.1 48356 D 561276 CDS YP_002510144.1 221230992 7329034 50522..51871 1 NC_011900.1 bacteriocin transport accessory protein 51871 7329034 SPN23F_00600 Streptococcus pneumoniae ATCC 700669 bacteriocin transport accessory protein YP_002510144.1 50522 D 561276 CDS YP_002510145.1 221230993 7329035 52041..52748 1 NC_011900.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase 52748 purC 7329035 purC Streptococcus pneumoniae ATCC 700669 phosphoribosylaminoimidazole-succinocarboxamide synthase YP_002510145.1 52041 D 561276 CDS YP_002510146.1 221230994 7327898 52805..56530 1 NC_011900.1 phosphoribosylformylglycinamidine synthase protein 56530 7327898 SPN23F_00620 Streptococcus pneumoniae ATCC 700669 phosphoribosylformylglycinamidine synthase protein YP_002510146.1 52805 D 561276 CDS YP_002510147.1 221230995 7329036 56623..58065 1 NC_011900.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 58065 purF 7329036 purF Streptococcus pneumoniae ATCC 700669 amidophosphoribosyltransferase YP_002510147.1 56623 D 561276 CDS YP_002510148.1 221230996 7327421 58102..59124 1 NC_011900.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 59124 purM 7327421 purM Streptococcus pneumoniae ATCC 700669 phosphoribosylaminoimidazole synthetase YP_002510148.1 58102 D 561276 CDS YP_002510149.1 221230997 7327424 59121..59666 1 NC_011900.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 59666 purN 7327424 purN Streptococcus pneumoniae ATCC 700669 phosphoribosylglycinamide formyltransferase YP_002510149.1 59121 D 561276 CDS YP_002510150.1 221230998 7327425 59750..60259 1 NC_011900.1 This gene gives low level resistance and is seperate from the 5 gene vancomysin resistance cluster on Tn1546. Forms a low GC trough.; VanZ-family resistance protein 60259 vanZ 7327425 vanZ Streptococcus pneumoniae ATCC 700669 VanZ-family resistance protein YP_002510150.1 59750 D 561276 CDS YP_002510151.1 221230999 7329427 60284..61831 1 NC_011900.1 involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 61831 purH 7329427 purH Streptococcus pneumoniae ATCC 700669 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase YP_002510151.1 60284 D 561276 CDS YP_002510152.1 221231000 7327422 61953..63215 1 NC_011900.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 63215 purD 7327422 purD Streptococcus pneumoniae ATCC 700669 phosphoribosylamine--glycine ligase YP_002510152.1 61953 D 561276 CDS YP_002510153.1 221231001 7327419 63585..64106 1 NC_011900.1 phosphoribosylaminoimidazole carboxylase catalytic subunit 64106 purE 7327419 purE Streptococcus pneumoniae ATCC 700669 phosphoribosylaminoimidazole carboxylase catalytic subunit YP_002510153.1 63585 D 561276 CDS YP_002510154.1 221231002 7327420 64093..65166 1 NC_011900.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 65166 purK 7327420 purK Streptococcus pneumoniae ATCC 700669 phosphoribosylaminoimidazole carboxylase ATPase subunit YP_002510154.1 64093 D 561276 CDS YP_002510155.1 221231003 7327423 65189..67576 1 NC_011900.1 ATP/GTP binding protein 67576 7327423 SPN23F_00710 Streptococcus pneumoniae ATCC 700669 ATP/GTP binding protein YP_002510155.1 65189 D 561276 CDS YP_002510156.1 221231004 7329037 67749..69047 1 NC_011900.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 69047 purB 7329037 purB Streptococcus pneumoniae ATCC 700669 adenylosuccinate lyase YP_002510156.1 67749 D 561276 CDS YP_002510157.1 221231005 7327897 complement(69102..73040) 1 NC_011900.1 beta-N-acetylhexosaminidase precursor 73040 strH 7327897 strH Streptococcus pneumoniae ATCC 700669 beta-N-acetylhexosaminidase precursor YP_002510157.1 69102 R 561276 CDS YP_002510158.1 221231006 7329158 complement(73355..74098) 1 NC_011900.1 GntR family transcriptional regulator 74098 7329158 SPN23F_00740 Streptococcus pneumoniae ATCC 700669 GntR family transcriptional regulator YP_002510158.1 73355 R 561276 CDS YP_002510159.1 221231007 7329038 74419..76206 1 NC_011900.1 beta-galactosidase 76206 7329038 SPN23F_00750 Streptococcus pneumoniae ATCC 700669 beta-galactosidase YP_002510159.1 74419 D 561276 CDS YP_002510160.1 221231008 7329039 76203..76679 1 NC_011900.1 sugar phosphotransferase system (PTS), sorbose subfamily, IIB component 76679 7329039 SPN23F_00760 Streptococcus pneumoniae ATCC 700669 sugar phosphotransferase system (PTS), sorbose subfamily, IIB component YP_002510160.1 76203 D 561276 CDS YP_002510161.1 221231009 7329040 76707..77612 1 NC_011900.1 sugar phosphotransferase system (PTS),sorbose-specific family, IIC component 77612 7329040 SPN23F_00770 Streptococcus pneumoniae ATCC 700669 sugar phosphotransferase system (PTS),sorbose-specific family, IIC component YP_002510161.1 76707 D 561276 CDS YP_002510162.1 221231010 7329041 77599..78414 1 NC_011900.1 sugar phosphotransferase system (PTS),mannose/fructose/sorbose family, IID component 78414 7329041 SPN23F_00780 Streptococcus pneumoniae ATCC 700669 sugar phosphotransferase system (PTS),mannose/fructose/sorbose family, IID component YP_002510162.1 77599 D 561276 CDS YP_002510163.1 221231011 7329042 78487..78825 1 NC_011900.1 sugar phosphotransferase system (PTS), fructose family, IIA component 78825 7329042 SPN23F_00790 Streptococcus pneumoniae ATCC 700669 sugar phosphotransferase system (PTS), fructose family, IIA component YP_002510163.1 78487 D 561276 CDS YP_002510164.1 221231012 7329043 79078..80244 1 NC_011900.1 tagatose-6-phosphate aldose/ketose isomerase 80244 agaS 7329043 agaS Streptococcus pneumoniae ATCC 700669 tagatose-6-phosphate aldose/ketose isomerase YP_002510164.1 79078 D 561276 CDS YP_002510165.1 221231013 7328641 80360..81397 1 NC_011900.1 aldose 1-epimerase 81397 7328641 SPN23F_00810 Streptococcus pneumoniae ATCC 700669 aldose 1-epimerase YP_002510165.1 80360 D 561276 CDS YP_002510166.1 221231014 7329044 81605..82459 1 NC_011900.1 glyoxalase/bleomycin resistance protein/dioxygenase superfamily protein 82459 7329044 SPN23F_00820 Streptococcus pneumoniae ATCC 700669 glyoxalase/bleomycin resistance protein/dioxygenase superfamily protein YP_002510166.1 81605 D 561276 CDS YP_002510167.1 221231015 7329045 82644..82853 1 NC_011900.1 hypothetical protein 82853 7329045 SPN23F_00830 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510167.1 82644 D 561276 CDS YP_002510168.1 221231016 7329046 complement(82895..83257) 1 NC_011900.1 hypothetical protein 83257 7329046 SPN23F_00840 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510168.1 82895 R 561276 CDS YP_002510169.1 221231017 7329047 complement(83311..83607) 1 NC_011900.1 hypothetical protein 83607 7329047 SPN23F_00850 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510169.1 83311 R 561276 CDS YP_002510170.1 221231018 7329049 83828..84592 1 NC_011900.1 phosphorylase family protein 84592 7329049 SPN23F_00870 Streptococcus pneumoniae ATCC 700669 phosphorylase family protein YP_002510170.1 83828 D 561276 CDS YP_002510171.1 221231019 7329050 84848..85033 1 NC_011900.1 hypothetical protein 85033 7329050 SPN23F_00880 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510171.1 84848 D 561276 CDS YP_002510172.1 221231020 7329051 85202..86581 1 NC_011900.1 TrkH-family cation transport protein 86581 7329051 SPN23F_00890 Streptococcus pneumoniae ATCC 700669 TrkH-family cation transport protein YP_002510172.1 85202 D 561276 CDS YP_002510173.1 221231021 7329052 86595..87260 1 NC_011900.1 TrkA family cation transport protein 87260 7329052 SPN23F_00900 Streptococcus pneumoniae ATCC 700669 TrkA family cation transport protein YP_002510173.1 86595 D 561276 CDS YP_002510174.1 221231022 7329053 87395..87553 1 NC_011900.1 hypothetical protein 87553 7329053 SPN23F_00910 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510174.1 87395 D 561276 CDS YP_002510175.1 221231023 7329056 90409..91107 1 NC_011900.1 response regulator protein 91107 7329056 SPN23F_00950 Streptococcus pneumoniae ATCC 700669 response regulator protein YP_002510175.1 90409 D 561276 CDS YP_002510176.1 221231024 7329057 91104..92156 1 NC_011900.1 histidine kinase protein 92156 7329057 SPN23F_00960 Streptococcus pneumoniae ATCC 700669 histidine kinase protein YP_002510176.1 91104 D 561276 CDS YP_002510177.1 221231025 7329058 92351..92962 1 NC_011900.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 92962 rpsD 7329058 rpsD Streptococcus pneumoniae ATCC 700669 30S ribosomal protein S4 YP_002510177.1 92351 D 561276 CDS YP_002510178.1 221231026 7329061 94377..95306 1 NC_011900.1 binding-protein-dependent transport system membrane protein 95306 7329061 SPN23F_01020 Streptococcus pneumoniae ATCC 700669 binding-protein-dependent transport system membrane protein YP_002510178.1 94377 D 561276 CDS YP_002510179.1 221231027 7329062 95320..96243 1 NC_011900.1 binding-protein-dependent transport system membrane protein 96243 7329062 SPN23F_01030 Streptococcus pneumoniae ATCC 700669 binding-protein-dependent transport system membrane protein YP_002510179.1 95320 D 561276 CDS YP_002510180.1 221231028 7329063 96453..97928 1 NC_011900.1 extracellular solute-binding protein 97928 7329063 SPN23F_01040 Streptococcus pneumoniae ATCC 700669 extracellular solute-binding protein YP_002510180.1 96453 D 561276 CDS YP_002510181.1 221231029 7329064 98200..99186 1 NC_011900.1 hypothetical protein 99186 7329064 SPN23F_01050 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510181.1 98200 D 561276 CDS YP_002510182.1 221231030 7329065 99460..100320 1 NC_011900.1 hypothetical protein 100320 7329065 SPN23F_01060 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510182.1 99460 D 561276 CDS YP_002510183.1 221231031 7329066 complement(100392..101456) 1 NC_011900.1 hypothetical protein 101456 7329066 SPN23F_01070 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510183.1 100392 R 561276 CDS YP_002510184.1 221231032 7329067 complement(101518..102429) 1 NC_011900.1 hypothetical protein 102429 7329067 SPN23F_01080 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510184.1 101518 R 561276 CDS YP_002510185.1 221231033 7329068 complement(102422..103015) 1 NC_011900.1 hypothetical protein 103015 7329068 SPN23F_01090 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510185.1 102422 R 561276 CDS YP_002510186.1 221231034 7329069 complement(103002..103328) 1 NC_011900.1 PadR family transcriptional regulator 103328 7329069 SPN23F_01100 Streptococcus pneumoniae ATCC 700669 PadR family transcriptional regulator YP_002510186.1 103002 R 561276 CDS YP_002510187.1 221231035 7329072 104690..105847 1 NC_011900.1 glycosyl transferase 105847 7329072 SPN23F_01130 Streptococcus pneumoniae ATCC 700669 glycosyl transferase YP_002510187.1 104690 D 561276 CDS YP_002510188.1 221231036 7329073 105889..107739 1 NC_011900.1 polysaccharide biosynthesis protein 107739 7329073 SPN23F_01140 Streptococcus pneumoniae ATCC 700669 polysaccharide biosynthesis protein YP_002510188.1 105889 D 561276 CDS YP_002510189.1 221231037 7329074 complement(107779..109035) 1 NC_011900.1 IS1167 transposase 109035 7329074 SPN23F_01150 Streptococcus pneumoniae ATCC 700669 IS1167 transposase YP_002510189.1 107779 R 561276 CDS YP_002510190.1 221231038 7329075 complement(109187..109393) 1 NC_011900.1 hypothetical protein 109393 7329075 SPN23F_01160 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510190.1 109187 R 561276 CDS YP_002510191.1 221231039 7329076 complement(109510..110142) 1 NC_011900.1 5'-nucleotidase 110142 7329076 SPN23F_01170 Streptococcus pneumoniae ATCC 700669 5'-nucleotidase YP_002510191.1 109510 R 561276 CDS YP_002510192.1 221231040 7329077 complement(110164..111036) 1 NC_011900.1 L-serine dehydratase, alpha chain 111036 sdhA 7329077 sdhA Streptococcus pneumoniae ATCC 700669 L-serine dehydratase, alpha chain YP_002510192.1 110164 R 561276 CDS YP_002510193.1 221231041 7329138 complement(111045..111716) 1 NC_011900.1 L-serine dehydratase, beta chain 111716 sdhB 7329138 sdhB Streptococcus pneumoniae ATCC 700669 L-serine dehydratase, beta chain YP_002510193.1 111045 R 561276 CDS YP_002510194.1 221231042 7329139 111958..112545 1 NC_011900.1 peptidoglycan-binding protein 112545 7329139 SPN23F_01200 Streptococcus pneumoniae ATCC 700669 peptidoglycan-binding protein YP_002510194.1 111958 D 561276 CDS YP_002510195.1 221231043 7329085 113349..113636 1 NC_011900.1 bacteriocin 113636 7329085 SPN23F_01202 Streptococcus pneumoniae ATCC 700669 bacteriocin YP_002510195.1 113349 D 561276 CDS YP_002510196.1 221231044 7329080 113688..115796 1 NC_011900.1 hypothetical protein 115796 7329080 SPN23F_01210 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510196.1 113688 D 561276 CDS YP_002510197.1 221231045 7329081 115793..116434 1 NC_011900.1 ABC transporter ATP-binding protein 116434 7329081 SPN23F_01220 Streptococcus pneumoniae ATCC 700669 ABC transporter ATP-binding protein YP_002510197.1 115793 D 561276 CDS YP_002510198.1 221231046 7329082 116641..117447 1 NC_011900.1 extracellular amino acid-binding protein 117447 7329082 SPN23F_01230 Streptococcus pneumoniae ATCC 700669 extracellular amino acid-binding protein YP_002510198.1 116641 D 561276 CDS YP_002510199.1 221231047 7329079 complement(119110..120366) 1 NC_011900.1 transposase 120366 7329079 SPN23F_01250 Streptococcus pneumoniae ATCC 700669 transposase YP_002510199.1 119110 R 561276 CDS YP_002510200.1 221231048 7329087 121031..121759 1 NC_011900.1 hypothetical protein 121759 7329087 SPN23F_01270 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510200.1 121031 D 561276 CDS YP_002510201.1 221231049 7329088 122894..123133 1 NC_011900.1 hypothetical protein 123133 7329088 SPN23F_01280 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510201.1 122894 D 561276 CDS YP_002510202.1 221231050 7327883 126259..127380 1 NC_011900.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 127380 mnmA 7327883 mnmA Streptococcus pneumoniae ATCC 700669 tRNA-specific 2-thiouridylase MnmA YP_002510202.1 126259 D 561276 CDS YP_002510203.1 221231051 7329090 127521..127976 1 NC_011900.1 MutT/NUDIX hydrolase family protein 127976 7329090 SPN23F_01330 Streptococcus pneumoniae ATCC 700669 MutT/NUDIX hydrolase family protein YP_002510203.1 127521 D 561276 CDS YP_002510204.1 221231052 7329091 127986..129899 1 NC_011900.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA 129899 gidA 7329091 gidA Streptococcus pneumoniae ATCC 700669 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA YP_002510204.1 127986 D 561276 CDS YP_002510205.1 221231053 7328592 complement(130278..131957) 1 NC_011900.1 metallo-beta-lactamase superfamily protein 131957 7328592 SPN23F_01350 Streptococcus pneumoniae ATCC 700669 metallo-beta-lactamase superfamily protein YP_002510205.1 130278 R 561276 CDS YP_002510206.1 221231054 7329092 complement(131959..132192) 1 NC_011900.1 hypothetical protein 132192 7329092 SPN23F_01360 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510206.1 131959 R 561276 CDS YP_002510207.1 221231055 7329190 complement(133010..133162) 1 NC_011900.1 hypothetical protein 133162 7329190 SPN23F_01370 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510207.1 133010 R 561276 CDS YP_002510208.1 221231056 7329094 complement(133164..133349) 1 NC_011900.1 hypothetical protein 133349 7329094 SPN23F_01380 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510208.1 133164 R 561276 CDS YP_002510209.1 221231057 7329095 133527..134210 1 NC_011900.1 glycoprotease family protein 134210 7329095 SPN23F_01390 Streptococcus pneumoniae ATCC 700669 glycoprotease family protein YP_002510209.1 133527 D 561276 CDS YP_002510210.1 221231058 7329096 134207..134644 1 NC_011900.1 GNAT family acetyltransferase 134644 7329096 SPN23F_01400 Streptococcus pneumoniae ATCC 700669 GNAT family acetyltransferase YP_002510210.1 134207 D 561276 CDS YP_002510211.1 221231059 7329097 134634..135644 1 NC_011900.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; DNA-binding/iron metalloprotein/AP endonuclease 135644 7329097 SPN23F_01410 Streptococcus pneumoniae ATCC 700669 DNA-binding/iron metalloprotein/AP endonuclease YP_002510211.1 134634 D 561276 CDS YP_002510212.1 221231060 7329099 complement(136061..136990) 1 NC_011900.1 transposase 136990 7329099 SPN23F_01430 Streptococcus pneumoniae ATCC 700669 transposase YP_002510212.1 136061 R 561276 CDS YP_002510213.1 221231061 7327902 139459..140412 1 NC_011900.1 glycosyl transferase 140412 7327902 SPN23F_01460 Streptococcus pneumoniae ATCC 700669 glycosyl transferase YP_002510213.1 139459 D 561276 CDS YP_002510214.1 221231062 7327903 140422..142038 1 NC_011900.1 ABC transporter ATP-binding protein/permease 142038 7327903 SPN23F_01470 Streptococcus pneumoniae ATCC 700669 ABC transporter ATP-binding protein/permease YP_002510214.1 140422 D 561276 CDS YP_002510215.1 221231063 7327906 142827..143576 1 NC_011900.1 acetyltransferase 143576 7327906 SPN23F_01490 Streptococcus pneumoniae ATCC 700669 acetyltransferase YP_002510215.1 142827 D 561276 CDS YP_002510216.1 221231064 7327907 143589..144761 1 NC_011900.1 UDP-glucose 6-dehydrogenase 144761 ugd 7327907 ugd Streptococcus pneumoniae ATCC 700669 UDP-glucose 6-dehydrogenase YP_002510216.1 143589 D 561276 CDS YP_002510217.1 221231065 7327660 145157..146020 1 NC_011900.1 hypothetical protein 146020 7327660 SPN23F_01510 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510217.1 145157 D 561276 CDS YP_002510218.1 221231066 7327908 146306..146506 1 NC_011900.1 hypothetical protein 146506 7327908 SPN23F_01520 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510218.1 146306 D 561276 CDS YP_002510219.1 221231067 7327909 146573..147238 1 NC_011900.1 membrane protease 147238 7327909 SPN23F_01530 Streptococcus pneumoniae ATCC 700669 membrane protease YP_002510219.1 146573 D 561276 CDS YP_002510220.1 221231068 7327910 147310..148536 1 NC_011900.1 transport protein 148536 7327910 SPN23F_01540 Streptococcus pneumoniae ATCC 700669 transport protein YP_002510220.1 147310 D 561276 CDS YP_002510221.1 221231069 7327911 148989..149645 1 NC_011900.1 AzlC-family transport protein 149645 7327911 SPN23F_01550 Streptococcus pneumoniae ATCC 700669 AzlC-family transport protein YP_002510221.1 148989 D 561276 CDS YP_002510222.1 221231070 7327912 149635..149844 1 NC_011900.1 AzlD-like membrane transport protein 149844 7327912 SPN23F_01560 Streptococcus pneumoniae ATCC 700669 AzlD-like membrane transport protein YP_002510222.1 149635 D 561276 CDS YP_002510223.1 221231071 7327913 150062..150892 1 NC_011900.1 extracellular solute-binding protein 150892 7327913 SPN23F_01570 Streptococcus pneumoniae ATCC 700669 extracellular solute-binding protein YP_002510223.1 150062 D 561276 CDS YP_002510224.1 221231072 7327914 151046..151900 1 NC_011900.1 lipoprotein 151900 7327914 SPN23F_01580 Streptococcus pneumoniae ATCC 700669 lipoprotein YP_002510224.1 151046 D 561276 CDS YP_002510225.1 221231073 7327915 152000..153373 1 NC_011900.1 peptidase 153373 7327915 SPN23F_01590 Streptococcus pneumoniae ATCC 700669 peptidase YP_002510225.1 152000 D 561276 CDS YP_002510226.1 221231074 7327916 153366..154427 1 NC_011900.1 ABC transporter ATP-binding protein 154427 7327916 SPN23F_01600 Streptococcus pneumoniae ATCC 700669 ABC transporter ATP-binding protein YP_002510226.1 153366 D 561276 CDS YP_002510227.1 221231075 7327917 154429..155121 1 NC_011900.1 ABC transporter system permease protein 155121 7327917 SPN23F_01610 Streptococcus pneumoniae ATCC 700669 ABC transporter system permease protein YP_002510227.1 154429 D 561276 CDS YP_002510228.1 221231076 7327918 complement(155151..155720) 1 NC_011900.1 hypothetical protein 155720 7327918 SPN23F_01620 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510228.1 155151 R 561276 CDS YP_002510229.1 221231077 7327919 155855..156469 1 NC_011900.1 hypothetical protein 156469 7327919 SPN23F_01630 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510229.1 155855 D 561276 CDS YP_002510230.1 221231078 7327920 156519..158117 1 NC_011900.1 histidine sensor kinase 158117 7327920 SPN23F_01640 Streptococcus pneumoniae ATCC 700669 histidine sensor kinase YP_002510230.1 156519 D 561276 CDS YP_002510231.1 221231079 7327921 158129..159415 1 NC_011900.1 response regulator protein 159415 7327921 SPN23F_01650 Streptococcus pneumoniae ATCC 700669 response regulator protein YP_002510231.1 158129 D 561276 CDS YP_002510232.1 221231080 7327922 159476..160009 1 NC_011900.1 hypothetical protein 160009 7327922 SPN23F_01660 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510232.1 159476 D 561276 CDS YP_002510233.1 221231081 7327923 160087..160557 1 NC_011900.1 has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; flavoprotein NrdI 160557 7327923 SPN23F_01670 Streptococcus pneumoniae ATCC 700669 flavoprotein NrdI YP_002510233.1 160087 D 561276 CDS YP_002510234.1 221231082 7327924 complement(160850..162112) 1 NC_011900.1 integral membrane protein 162112 7327924 SPN23F_01680 Streptococcus pneumoniae ATCC 700669 integral membrane protein YP_002510234.1 160850 R 561276 CDS YP_002510235.1 221231083 7327925 complement(162422..162880) 1 NC_011900.1 hypothetical protein 162880 7327925 SPN23F_01690 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510235.1 162422 R 561276 CDS YP_002510236.1 221231084 7327926 complement(162877..163317) 1 NC_011900.1 DNA-binding protein 163317 7327926 SPN23F_01700 Streptococcus pneumoniae ATCC 700669 DNA-binding protein YP_002510236.1 162877 R 561276 CDS YP_002510237.1 221231085 7327927 163673..165622 1 NC_011900.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein 165622 mutL 7327927 mutL Streptococcus pneumoniae ATCC 700669 DNA mismatch repair protein YP_002510237.1 163673 D 561276 CDS YP_002510238.1 221231086 7328401 complement(165947..166414) 1 NC_011900.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase 166414 ribH 7328401 ribH Streptococcus pneumoniae ATCC 700669 6,7-dimethyl-8-ribityllumazine synthase YP_002510238.1 165947 R 561276 CDS YP_002510239.1 221231087 7327456 complement(166415..167620) 1 NC_011900.1 riboflavin biosynthesis protein 167620 ribA 7327456 ribA Streptococcus pneumoniae ATCC 700669 riboflavin biosynthesis protein YP_002510239.1 166415 R 561276 CDS YP_002510240.1 221231088 7327452 complement(167640..168275) 1 NC_011900.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha 168275 ribE 7327452 ribE Streptococcus pneumoniae ATCC 700669 riboflavin synthase subunit alpha YP_002510240.1 167640 R 561276 CDS YP_002510241.1 221231089 7327455 complement(168260..169360) 1 NC_011900.1 riboflavin biosynthesis protein 169360 ribD 7327455 ribD Streptococcus pneumoniae ATCC 700669 riboflavin biosynthesis protein YP_002510241.1 168260 R 561276 CDS YP_002510242.1 221231090 7329459 169765..170358 1 NC_011900.1 plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 170358 ruvA 7329459 ruvA Streptococcus pneumoniae ATCC 700669 Holliday junction DNA helicase RuvA YP_002510242.1 169765 D 561276 CDS YP_002510243.1 221231091 7329129 170368..170931 1 NC_011900.1 DNA-3-methyladenine glycosylase I 170931 tag 7329129 tag Streptococcus pneumoniae ATCC 700669 DNA-3-methyladenine glycosylase I YP_002510243.1 170368 D 561276 CDS YP_002510244.1 221231092 7329162 170928..171605 1 NC_011900.1 protease 171605 7329162 SPN23F_01780 Streptococcus pneumoniae ATCC 700669 protease YP_002510244.1 170928 D 561276 CDS YP_002510245.1 221231093 7327928 complement(171742..172773) 1 NC_011900.1 carboxypeptidase 172773 7327928 SPN23F_01790 Streptococcus pneumoniae ATCC 700669 carboxypeptidase YP_002510245.1 171742 R 561276 CDS YP_002510246.1 221231094 7327929 complement(173028..173711) 1 NC_011900.1 hypothetical protein 173711 7327929 SPN23F_01800 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510246.1 173028 R 561276 CDS YP_002510247.1 221231095 7327930 complement(173723..174667) 1 NC_011900.1 CorA-like Mg2+ transporter protein 174667 7327930 SPN23F_01810 Streptococcus pneumoniae ATCC 700669 CorA-like Mg2+ transporter protein YP_002510247.1 173723 R 561276 CDS YP_002510248.1 221231096 7327931 174799..177630 1 NC_011900.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 177630 uvrA 7327931 uvrA Streptococcus pneumoniae ATCC 700669 excinuclease ABC subunit A YP_002510248.1 174799 D 561276 CDS YP_002510249.1 221231097 7329423 177623..178684 1 NC_011900.1 metallopeptidase 178684 7329423 SPN23F_01830 Streptococcus pneumoniae ATCC 700669 metallopeptidase YP_002510249.1 177623 D 561276 CDS YP_002510250.1 221231098 7327932 178816..179214 1 NC_011900.1 the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress; Spx family transcriptional regulator 179214 spxA 7327932 spxA Streptococcus pneumoniae ATCC 700669 Spx family transcriptional regulator YP_002510250.1 178816 D 561276 CDS YP_002510251.1 221231099 7327933 179280..179849 1 NC_011900.1 lipoprotein 179849 7327933 SPN23F_01850 Streptococcus pneumoniae ATCC 700669 lipoprotein YP_002510251.1 179280 D 561276 CDS YP_002510252.1 221231100 7327934 179936..180202 1 NC_011900.1 hypothetical protein 180202 7327934 SPN23F_01860 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510252.1 179936 D 561276 CDS YP_002510253.1 221231101 7327935 180215..180625 1 NC_011900.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 180625 7327935 SPN23F_01870 Streptococcus pneumoniae ATCC 700669 Holliday junction resolvase-like protein YP_002510253.1 180215 D 561276 CDS YP_002510254.1 221231102 7327936 180641..180946 1 NC_011900.1 hypothetical protein 180946 7327936 SPN23F_01880 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510254.1 180641 D 561276 CDS YP_002510255.1 221231103 7327937 181204..182454 1 NC_011900.1 folylpolyglutamate synthase 182454 7327937 SPN23F_01890 Streptococcus pneumoniae ATCC 700669 folylpolyglutamate synthase YP_002510255.1 181204 D 561276 CDS YP_002510256.1 221231104 7327938 182538..182993 1 NC_011900.1 lipoprotein 182993 7327938 SPN23F_01900 Streptococcus pneumoniae ATCC 700669 lipoprotein YP_002510256.1 182538 D 561276 CDS YP_002510257.1 221231105 7327939 183139..184671 1 NC_011900.1 cardiolipin synthetase 184671 7327939 SPN23F_01910 Streptococcus pneumoniae ATCC 700669 cardiolipin synthetase YP_002510257.1 183139 D 561276 CDS YP_002510258.1 221231106 7327940 184929..186467 1 NC_011900.1 hypothetical protein 186467 7327940 SPN23F_01920 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510258.1 184929 D 561276 CDS YP_002510259.1 221231107 7327941 186587..188794 1 NC_011900.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; anaerobic ribonucleoside triphosphate reductase 188794 nrdD 7327941 nrdD Streptococcus pneumoniae ATCC 700669 anaerobic ribonucleoside triphosphate reductase YP_002510259.1 186587 D 561276 CDS YP_002510260.1 221231108 7328422 188806..188946 1 NC_011900.1 hypothetical protein 188946 7328422 SPN23F_01940 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510260.1 188806 D 561276 CDS YP_002510261.1 221231109 7327942 188990..189496 1 NC_011900.1 GNAT family acetyltransferase 189496 7327942 SPN23F_01950 Streptococcus pneumoniae ATCC 700669 GNAT family acetyltransferase YP_002510261.1 188990 D 561276 CDS YP_002510262.1 221231110 7327943 189489..190079 1 NC_011900.1 anaerobic ribonucleoside-triphosphate reductase activating protein 190079 nrdG 7327943 nrdG Streptococcus pneumoniae ATCC 700669 anaerobic ribonucleoside-triphosphate reductase activating protein YP_002510262.1 189489 D 561276 CDS YP_002510263.1 221231111 7328423 190076..190693 1 NC_011900.1 phosphoribulokinase 190693 7328423 SPN23F_01970 Streptococcus pneumoniae ATCC 700669 phosphoribulokinase YP_002510263.1 190076 D 561276 CDS YP_002510264.1 221231112 7327944 190960..191268 1 NC_011900.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 191268 rpsJ 7327944 rpsJ Streptococcus pneumoniae ATCC 700669 30S ribosomal protein S10 YP_002510264.1 190960 D 561276 CDS YP_002510265.1 221231113 7329117 191484..192110 1 NC_011900.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 192110 rplC 7329117 rplC Streptococcus pneumoniae ATCC 700669 50S ribosomal protein L3 YP_002510265.1 191484 D 561276 CDS YP_002510266.1 221231114 7327472 192135..192758 1 NC_011900.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 192758 rplD 7327472 rplD Streptococcus pneumoniae ATCC 700669 50S ribosomal protein L4 YP_002510266.1 192135 D 561276 CDS YP_002510267.1 221231115 7327473 192758..193054 1 NC_011900.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 193054 rplW 7327473 rplW Streptococcus pneumoniae ATCC 700669 50S ribosomal protein L23 YP_002510267.1 192758 D 561276 CDS YP_002510268.1 221231116 7327490 193072..193905 1 NC_011900.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 193905 rplB 7327490 rplB Streptococcus pneumoniae ATCC 700669 50S ribosomal protein L2 YP_002510268.1 193072 D 561276 CDS YP_002510269.1 221231117 7327471 194009..194290 1 NC_011900.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 194290 rpsS 7327471 rpsS Streptococcus pneumoniae ATCC 700669 30S ribosomal protein S19 YP_002510269.1 194009 D 561276 CDS YP_002510270.1 221231118 7329125 194302..194646 1 NC_011900.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 194646 rplV 7329125 rplV Streptococcus pneumoniae ATCC 700669 50S ribosomal protein L22 YP_002510270.1 194302 D 561276 CDS YP_002510271.1 221231119 7327489 194659..195312 1 NC_011900.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 195312 rpsC 7327489 rpsC Streptococcus pneumoniae ATCC 700669 30S ribosomal protein S3 YP_002510271.1 194659 D 561276 CDS YP_002510272.1 221231120 7329110 195316..195729 1 NC_011900.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 195729 rplP 7329110 rplP Streptococcus pneumoniae ATCC 700669 50S ribosomal protein L16 YP_002510272.1 195316 D 561276 CDS YP_002510273.1 221231121 7327483 195739..195945 1 NC_011900.1 one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 195945 rpmC 7327483 rpmC Streptococcus pneumoniae ATCC 700669 50S ribosomal protein L29 YP_002510273.1 195739 D 561276 CDS YP_002510274.1 221231122 7327494 195970..196230 1 NC_011900.1 primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 196230 rpsQ 7327494 rpsQ Streptococcus pneumoniae ATCC 700669 30S ribosomal protein S17 YP_002510274.1 195970 D 561276 CDS YP_002510275.1 221231123 7329123 196256..196624 1 NC_011900.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 196624 rplN 7329123 rplN Streptococcus pneumoniae ATCC 700669 50S ribosomal protein L14 YP_002510275.1 196256 D 561276 CDS YP_002510276.1 221231124 7327481 196702..197007 1 NC_011900.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 197007 rplX 7327481 rplX Streptococcus pneumoniae ATCC 700669 50S ribosomal protein L24 YP_002510276.1 196702 D 561276 CDS YP_002510277.1 221231125 7327491 197031..197573 1 NC_011900.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 197573 rplE 7327491 rplE Streptococcus pneumoniae ATCC 700669 50S ribosomal protein L5 YP_002510277.1 197031 D 561276 CDS YP_002510278.1 221231126 7327474 197591..197860 1 NC_011900.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 197860 rpsN 7327474 rpsN Streptococcus pneumoniae ATCC 700669 30S ribosomal protein S14 YP_002510278.1 197591 D 561276 CDS YP_002510279.1 221231127 7327945 198145..198543 1 NC_011900.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 198543 rpsH 7327945 rpsH Streptococcus pneumoniae ATCC 700669 30S ribosomal protein S8 YP_002510279.1 198145 D 561276 CDS YP_002510280.1 221231128 7329115 198735..199271 1 NC_011900.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 199271 rplF 7329115 rplF Streptococcus pneumoniae ATCC 700669 50S ribosomal protein L6 YP_002510280.1 198735 D 561276 CDS YP_002510281.1 221231129 7327475 199355..199711 1 NC_011900.1 binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 199711 rplR 7327475 rplR Streptococcus pneumoniae ATCC 700669 50S ribosomal protein L18 YP_002510281.1 199355 D 561276 CDS YP_002510282.1 221231130 7327485 199729..200223 1 NC_011900.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 200223 rpsE 7327485 rpsE Streptococcus pneumoniae ATCC 700669 30S ribosomal protein S5 YP_002510282.1 199729 D 561276 CDS YP_002510283.1 221231131 7329112 200237..200419 1 NC_011900.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 200419 rpmD 7329112 rpmD Streptococcus pneumoniae ATCC 700669 50S ribosomal protein L30 YP_002510283.1 200237 D 561276 CDS YP_002510284.1 221231132 7327495 200564..201004 1 NC_011900.1 late assembly protein; 50S ribosomal protein L15 201004 rplO 7327495 rplO Streptococcus pneumoniae ATCC 700669 50S ribosomal protein L15 YP_002510284.1 200564 D 561276 CDS YP_002510285.1 221231133 7327482 201017..202327 1 NC_011900.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 202327 secY 7327482 secY Streptococcus pneumoniae ATCC 700669 preprotein translocase subunit SecY YP_002510285.1 201017 D 561276 CDS YP_002510286.1 221231134 7329142 202478..203116 1 NC_011900.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 203116 adk 7329142 adk Streptococcus pneumoniae ATCC 700669 adenylate kinase YP_002510286.1 202478 D 561276 CDS YP_002510287.1 221231135 7328638 203233..203451 1 NC_011900.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 203451 infA 7328638 infA Streptococcus pneumoniae ATCC 700669 translation initiation factor IF-1 YP_002510287.1 203233 D 561276 CDS YP_002510288.1 221231136 7328085 203610..203975 1 NC_011900.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 203975 rpsM 7328085 rpsM Streptococcus pneumoniae ATCC 700669 30S ribosomal protein S13 YP_002510288.1 203610 D 561276 CDS YP_002510289.1 221231137 7329120 203993..204376 1 NC_011900.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 204376 rpsK 7329120 rpsK Streptococcus pneumoniae ATCC 700669 30S ribosomal protein S11 YP_002510289.1 203993 D 561276 CDS YP_002510290.1 221231138 7329118 204419..205354 1 NC_011900.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 205354 rpoA 7329118 rpoA Streptococcus pneumoniae ATCC 700669 DNA-directed RNA polymerase subunit alpha YP_002510290.1 204419 D 561276 CDS YP_002510291.1 221231139 7329103 205366..205752 1 NC_011900.1 is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 205752 rplQ 7329103 rplQ Streptococcus pneumoniae ATCC 700669 50S ribosomal protein L17 YP_002510291.1 205366 D 561276 CDS YP_002510292.1 221231140 7327484 206017..206283 1 NC_011900.1 ACT domain-containing protein; hypothetical protein 206283 7327484 SPN23F_02260 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510292.1 206017 D 561276 CDS YP_002510293.1 221231141 7327946 206293..207630 1 NC_011900.1 hypothetical protein 207630 7327946 SPN23F_02270 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510293.1 206293 D 561276 CDS YP_002510294.1 221231142 7327947 207874..208566 1 NC_011900.1 phosphoglycerate mutase family protein 208566 7327947 SPN23F_02280 Streptococcus pneumoniae ATCC 700669 phosphoglycerate mutase family protein YP_002510294.1 207874 D 561276 CDS YP_002510295.1 221231143 7327948 complement(208669..209082) 1 NC_011900.1 ABC transporter permease 209082 7327948 SPN23F_02290 Streptococcus pneumoniae ATCC 700669 ABC transporter permease YP_002510295.1 208669 R 561276 CDS YP_002510296.1 221231144 7327949 complement(209079..209651) 1 NC_011900.1 inner membrane component of ABC transporter 209651 7327949 SPN23F_02300 Streptococcus pneumoniae ATCC 700669 inner membrane component of ABC transporter YP_002510296.1 209079 R 561276 CDS YP_002510297.1 221231145 7327950 complement(209678..210304) 1 NC_011900.1 ABC transporter permease 210304 7327950 SPN23F_02310 Streptococcus pneumoniae ATCC 700669 ABC transporter permease YP_002510297.1 209678 R 561276 CDS YP_002510298.1 221231146 7327951 complement(210294..211385) 1 NC_011900.1 ATP-binding component of ABC transporter 211385 7327951 SPN23F_02320 Streptococcus pneumoniae ATCC 700669 ATP-binding component of ABC transporter YP_002510298.1 210294 R 561276 CDS YP_002510299.1 221231147 7327953 complement(212736..212933) 1 NC_011900.1 AraC family transcriptional regulator 212933 7327953 SPN23F_02341 Streptococcus pneumoniae ATCC 700669 AraC family transcriptional regulator YP_002510299.1 212736 R 561276 CDS YP_002510300.1 221231148 7327954 complement(213008..213784) 1 NC_011900.1 pyruvate formate-lyase activating enzyme 213784 7327954 SPN23F_02350 Streptococcus pneumoniae ATCC 700669 pyruvate formate-lyase activating enzyme YP_002510300.1 213008 R 561276 CDS YP_002510301.1 221231149 7327955 213906..214652 1 NC_011900.1 DeoR family regulatory protein 214652 7327955 SPN23F_02360 Streptococcus pneumoniae ATCC 700669 DeoR family regulatory protein YP_002510301.1 213906 D 561276 CDS YP_002510302.1 221231150 7327956 214665..215645 1 NC_011900.1 sugar-binding regulatory protein 215645 7327956 SPN23F_02370 Streptococcus pneumoniae ATCC 700669 sugar-binding regulatory protein YP_002510302.1 214665 D 561276 CDS YP_002510303.1 221231151 7327957 215840..216160 1 NC_011900.1 sugar phosphotransferase system (PTS),lactose/cellobiose-specific family, IIA component 216160 7327957 SPN23F_02380 Streptococcus pneumoniae ATCC 700669 sugar phosphotransferase system (PTS),lactose/cellobiose-specific family, IIA component YP_002510303.1 215840 D 561276 CDS YP_002510304.1 221231152 7327958 216206..216514 1 NC_011900.1 sugar phosphotransferase system (PTS),lactose/cellobiose-specific family, IIB component 216514 7327958 SPN23F_02390 Streptococcus pneumoniae ATCC 700669 sugar phosphotransferase system (PTS),lactose/cellobiose-specific family, IIB component YP_002510304.1 216206 D 561276 CDS YP_002510305.1 221231153 7327959 216531..217829 1 NC_011900.1 sugar phosphotransferase system (PTS), IIC component 217829 7327959 SPN23F_02400 Streptococcus pneumoniae ATCC 700669 sugar phosphotransferase system (PTS), IIC component YP_002510305.1 216531 D 561276 CDS YP_002510306.1 221231154 7327960 217980..220418 1 NC_011900.1 formate acetyltransferase 220418 pflD 7327960 pflD Streptococcus pneumoniae ATCC 700669 formate acetyltransferase YP_002510306.1 217980 D 561276 CDS YP_002510307.1 221231155 7327836 220437..221105 1 NC_011900.1 similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase 221105 fsaA 7327836 fsaA Streptococcus pneumoniae ATCC 700669 fructose-6-phosphate aldolase YP_002510307.1 220437 D 561276 CDS YP_002510308.1 221231156 7328566 221123..222211 1 NC_011900.1 forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone; glycerol dehydrogenase 222211 gldA 7328566 gldA Streptococcus pneumoniae ATCC 700669 glycerol dehydrogenase YP_002510308.1 221123 D 561276 CDS YP_002510309.1 221231157 7328595 222666..225167 1 NC_011900.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 225167 leuS 7328595 leuS Streptococcus pneumoniae ATCC 700669 leucyl-tRNA synthetase YP_002510309.1 222666 D 561276 CDS YP_002510310.1 221231158 7328105 225361..226056 1 NC_011900.1 GNAT-family acetyltransferase 226056 7328105 SPN23F_02450 Streptococcus pneumoniae ATCC 700669 GNAT-family acetyltransferase YP_002510310.1 225361 D 561276 CDS YP_002510311.1 221231159 7327961 226068..226484 1 NC_011900.1 GNAT family acetyltransferase 226484 7327961 SPN23F_02460 Streptococcus pneumoniae ATCC 700669 GNAT family acetyltransferase YP_002510311.1 226068 D 561276 CDS YP_002510312.1 221231160 7327962 227552..228523 1 NC_011900.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 228523 ruvB 7327962 ruvB Streptococcus pneumoniae ATCC 700669 Holliday junction DNA helicase RuvB YP_002510312.1 227552 D 561276 CDS YP_002510313.1 221231161 7329130 228504..229076 1 NC_011900.1 hypothetical protein 229076 7329130 SPN23F_02480 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510313.1 228504 D 561276 CDS YP_002510314.1 221231162 7327963 229307..230065 1 NC_011900.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; UDP pyrophosphate synthase 230065 uppS 7327963 uppS Streptococcus pneumoniae ATCC 700669 UDP pyrophosphate synthase YP_002510314.1 229307 D 561276 CDS YP_002510315.1 221231163 7329422 230074..230877 1 NC_011900.1 phosphatidate cytidylyltransferase 230877 7329422 SPN23F_02500 Streptococcus pneumoniae ATCC 700669 phosphatidate cytidylyltransferase YP_002510315.1 230074 D 561276 CDS YP_002510316.1 221231164 7327964 230899..232158 1 NC_011900.1 pheromone-processing membrane metalloprotease 232158 eep 7327964 eep Streptococcus pneumoniae ATCC 700669 pheromone-processing membrane metalloprotease YP_002510316.1 230899 D 561276 CDS YP_002510317.1 221231165 7329250 232171..234024 1 NC_011900.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 234024 proS 7329250 proS Streptococcus pneumoniae ATCC 700669 prolyl-tRNA synthetase YP_002510317.1 232171 D 561276 CDS YP_002510318.1 221231166 7327879 234124..235503 1 NC_011900.1 beta-glucosidase 235503 7327879 SPN23F_02530 Streptococcus pneumoniae ATCC 700669 beta-glucosidase YP_002510318.1 234124 D 561276 CDS YP_002510319.1 221231167 7327965 235695..237503 1 NC_011900.1 isomerizing; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 237503 glmS 7327965 glmS Streptococcus pneumoniae ATCC 700669 glucosamine--fructose-6-phosphate aminotransferase YP_002510319.1 235695 D 561276 CDS YP_002510320.1 221231168 7328601 237622..238671 1 NC_011900.1 luciferase-like monooxygenase 238671 7328601 SPN23F_02550 Streptococcus pneumoniae ATCC 700669 luciferase-like monooxygenase YP_002510320.1 237622 D 561276 CDS YP_002510321.1 221231169 7327966 complement(238771..242568) 1 NC_011900.1 surface-anchored pullulanase 242568 7327966 SPN23F_02560 Streptococcus pneumoniae ATCC 700669 surface-anchored pullulanase YP_002510321.1 238771 R 561276 CDS YP_002510322.1 221231170 7327967 242985..243398 1 NC_011900.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 243398 rpsL 7327967 rpsL Streptococcus pneumoniae ATCC 700669 30S ribosomal protein S12 YP_002510322.1 242985 D 561276 CDS YP_002510323.1 221231171 7329119 243418..243888 1 NC_011900.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 243888 rpsG 7329119 rpsG Streptococcus pneumoniae ATCC 700669 30S ribosomal protein S7 YP_002510323.1 243418 D 561276 CDS YP_002510324.1 221231172 7329114 244283..246364 1 NC_011900.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 246364 fus 7329114 fus Streptococcus pneumoniae ATCC 700669 elongation factor G YP_002510324.1 244283 D 561276 CDS YP_002510325.1 221231173 7328579 246468..250859 1 NC_011900.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; required for leading strand synthesis; PolC exhibits 3' to 5' exonuclease activity; DNA polymerase III PolC 250859 polC 7328579 polC Streptococcus pneumoniae ATCC 700669 DNA polymerase III PolC YP_002510325.1 246468 D 561276 CDS YP_002510326.1 221231174 7327864 complement(250902..252158) 1 NC_011900.1 IS1167 transposase 252158 7327864 SPN23F_02610 Streptococcus pneumoniae ATCC 700669 IS1167 transposase YP_002510326.1 250902 R 561276 CDS YP_002510327.1 221231175 7327968 252385..252648 1 NC_011900.1 plasmid stabilization system antitoxin protein 252648 7327968 SPN23F_02620 Streptococcus pneumoniae ATCC 700669 plasmid stabilization system antitoxin protein YP_002510327.1 252385 D 561276 CDS YP_002510328.1 221231176 7327971 252939..253091 1 NC_011900.1 hypothetical protein 253091 7327971 SPN23F_02650 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510328.1 252939 D 561276 CDS YP_002510329.1 221231177 7327972 253113..254354 1 NC_011900.1 aminopeptidase PepS 254354 pepS 7327972 pepS Streptococcus pneumoniae ATCC 700669 aminopeptidase PepS YP_002510329.1 253113 D 561276 CDS YP_002510330.1 221231178 7327829 254364..254594 1 NC_011900.1 transglycosylase 254594 7327829 SPN23F_02670 Streptococcus pneumoniae ATCC 700669 transglycosylase YP_002510330.1 254364 D 561276 CDS YP_002510331.1 221231179 7327973 254863..255585 1 NC_011900.1 ribosomal small subunit pseudouridine synthase B 255585 7327973 SPN23F_02680 Streptococcus pneumoniae ATCC 700669 ribosomal small subunit pseudouridine synthase B YP_002510331.1 254863 D 561276 CDS YP_002510332.1 221231180 7327974 255802..257136 1 NC_011900.1 aminopeptidase C 257136 pepC 7327974 pepC Streptococcus pneumoniae ATCC 700669 aminopeptidase C YP_002510332.1 255802 D 561276 CDS YP_002510333.1 221231181 7327825 complement(257192..258103) 1 NC_011900.1 mannose-specific phosphotransferase system (PTS), IID component 258103 manN 7327825 manN Streptococcus pneumoniae ATCC 700669 mannose-specific phosphotransferase system (PTS), IID component YP_002510333.1 257192 R 561276 CDS YP_002510334.1 221231182 7328123 complement(258127..258930) 1 NC_011900.1 mannose-specific phosphotransferase system (PTS), IIC component 258930 manM 7328123 manM Streptococcus pneumoniae ATCC 700669 mannose-specific phosphotransferase system (PTS), IIC component YP_002510334.1 258127 R 561276 CDS YP_002510335.1 221231183 7328122 complement(258958..259947) 1 NC_011900.1 mannose-specific phosphotransferase system (PTS), IIAB component 259947 manL 7328122 manL Streptococcus pneumoniae ATCC 700669 mannose-specific phosphotransferase system (PTS), IIAB component YP_002510335.1 258958 R 561276 CDS YP_002510336.1 221231184 7328121 complement(260180..261199) 1 NC_011900.1 similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs; alcohol dehydrogenase 261199 adhP 7328121 adhP Streptococcus pneumoniae ATCC 700669 alcohol dehydrogenase YP_002510336.1 260180 R 561276 CDS YP_002510337.1 221231185 7328637 complement(261538..262350) 1 NC_011900.1 haloacid dehalogenase-like hydrolase 262350 7328637 SPN23F_02750 Streptococcus pneumoniae ATCC 700669 haloacid dehalogenase-like hydrolase YP_002510337.1 261538 R 561276 CDS YP_002510338.1 221231186 7327975 262540..263958 1 NC_011900.1 permease 263958 7327975 SPN23F_02760 Streptococcus pneumoniae ATCC 700669 permease YP_002510338.1 262540 D 561276 CDS YP_002510339.1 221231187 7327976 264011..264718 1 NC_011900.1 CAAX amino terminal protease family membrane protein 264718 7327976 SPN23F_02770 Streptococcus pneumoniae ATCC 700669 CAAX amino terminal protease family membrane protein YP_002510339.1 264011 D 561276 CDS YP_002510340.1 221231188 7327977 264808..265785 1 NC_011900.1 dihydropteroate synthase 265785 folP 7327977 folP Streptococcus pneumoniae ATCC 700669 dihydropteroate synthase YP_002510340.1 264808 D 561276 CDS YP_002510341.1 221231189 7328561 265787..267109 1 NC_011900.1 folylpolyglutamate synthase 267109 folC 7328561 folC Streptococcus pneumoniae ATCC 700669 folylpolyglutamate synthase YP_002510341.1 265787 D 561276 CDS YP_002510342.1 221231190 7328558 267090..267644 1 NC_011900.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 267644 folE 7328558 folE Streptococcus pneumoniae ATCC 700669 GTP cyclohydrolase I YP_002510342.1 267090 D 561276 CDS YP_002510343.1 221231191 7328560 267803..268615 1 NC_011900.1 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase 268615 7328560 SPN23F_02810 Streptococcus pneumoniae ATCC 700669 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase YP_002510343.1 267803 D 561276 CDS YP_002510344.1 221231192 7327978 complement(268660..268977) 1 NC_011900.1 hypothetical protein 268977 7327978 SPN23F_02820 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510344.1 268660 R 561276 CDS YP_002510345.1 221231193 7327979 269334..269780 1 NC_011900.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 269780 rplM 7327979 rplM Streptococcus pneumoniae ATCC 700669 50S ribosomal protein L13 YP_002510345.1 269334 D 561276 CDS YP_002510346.1 221231194 7327480 269799..270191 1 NC_011900.1 forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 270191 rpsI 7327480 rpsI Streptococcus pneumoniae ATCC 700669 30S ribosomal protein S9 YP_002510346.1 269799 D 561276 CDS YP_002510347.1 221231195 7327500 271598..273811 1 NC_011900.1 glycosylhydrolase 273811 7327500 SPN23F_02870 Streptococcus pneumoniae ATCC 700669 glycosylhydrolase YP_002510347.1 271598 D 561276 CDS YP_002510348.1 221231196 7327501 complement(274033..274509) 1 NC_011900.1 glutathione peroxidase 274509 7327501 SPN23F_02880 Streptococcus pneumoniae ATCC 700669 glutathione peroxidase YP_002510348.1 274033 R 561276 CDS YP_002510349.1 221231197 7327502 274732..277935 1 NC_011900.1 hyaluronate lyase 277935 7327502 SPN23F_02890 Streptococcus pneumoniae ATCC 700669 hyaluronate lyase YP_002510349.1 274732 D 561276 CDS YP_002510350.1 221231198 7327504 complement(279079..279708) 1 NC_011900.1 catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase 279708 kgdA 7327504 kgdA Streptococcus pneumoniae ATCC 700669 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase YP_002510350.1 279079 R 561276 CDS YP_002510351.1 221231199 7328089 complement(279718..280719) 1 NC_011900.1 PfkB family carbohydrate kinase 280719 7328089 SPN23F_02920 Streptococcus pneumoniae ATCC 700669 PfkB family carbohydrate kinase YP_002510351.1 279718 R 561276 CDS YP_002510352.1 221231200 7327505 complement(280750..281391) 1 NC_011900.1 hypothetical protein 281391 7327505 SPN23F_02930 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510352.1 280750 R 561276 CDS YP_002510353.1 221231201 7327506 complement(281410..282225) 1 NC_011900.1 Involved in the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate; gluconate 5-dehydrogenase 282225 idnO 7327506 idnO Streptococcus pneumoniae ATCC 700669 gluconate 5-dehydrogenase YP_002510353.1 281410 R 561276 CDS YP_002510354.1 221231202 7328079 282497..282931 1 NC_011900.1 N-acetylgalactosamine-specific phosphotransferase system (PTS), IIA component 282931 7328079 SPN23F_02950 Streptococcus pneumoniae ATCC 700669 N-acetylgalactosamine-specific phosphotransferase system (PTS), IIA component YP_002510354.1 282497 D 561276 CDS YP_002510355.1 221231203 7327507 282943..284133 1 NC_011900.1 unsaturated glucuronyl hydrolase 284133 ugl 7327507 ugl Streptococcus pneumoniae ATCC 700669 unsaturated glucuronyl hydrolase YP_002510355.1 282943 D 561276 CDS YP_002510356.1 221231204 7327579 284144..284635 1 NC_011900.1 N-acetylgalactosamine-specific phosphotransferase system (PTS), IIB component 284635 agaV 7327579 agaV Streptococcus pneumoniae ATCC 700669 N-acetylgalactosamine-specific phosphotransferase system (PTS), IIB component YP_002510356.1 284144 D 561276 CDS YP_002510357.1 221231205 7328642 284650..285429 1 NC_011900.1 N-acetylgalactosamine-specific phosphotransferase system (PTS), IIC component 285429 agaW 7328642 agaW Streptococcus pneumoniae ATCC 700669 N-acetylgalactosamine-specific phosphotransferase system (PTS), IIC component YP_002510357.1 284650 D 561276 CDS YP_002510358.1 221231206 7328643 285416..286234 1 NC_011900.1 N-acetylgalactosamine-specific phosphotransferase system (PTS), IID component 286234 agaD 7328643 agaD Streptococcus pneumoniae ATCC 700669 N-acetylgalactosamine-specific phosphotransferase system (PTS), IID component YP_002510358.1 285416 D 561276 CDS YP_002510359.1 221231207 7328640 286261..286527 1 NC_011900.1 hypothetical protein 286527 7328640 SPN23F_03000 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510359.1 286261 D 561276 CDS YP_002510360.1 221231208 7327508 286549..288450 1 NC_011900.1 heparinase II/III-like protein 288450 7327508 SPN23F_03010 Streptococcus pneumoniae ATCC 700669 heparinase II/III-like protein YP_002510360.1 286549 D 561276 CDS YP_002510361.1 221231209 7327509 288510..289511 1 NC_011900.1 LacI family transcriptional regulator 289511 7327509 SPN23F_03020 Streptococcus pneumoniae ATCC 700669 LacI family transcriptional regulator YP_002510361.1 288510 D 561276 CDS YP_002510362.1 221231210 7327510 complement(289621..289956) 1 NC_011900.1 membrane protein 289956 7327510 SPN23F_03030 Streptococcus pneumoniae ATCC 700669 membrane protein YP_002510362.1 289621 R 561276 CDS YP_002510363.1 221231211 7327511 complement(289967..290209) 1 NC_011900.1 hypothetical protein 290209 7327511 SPN23F_03040 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510363.1 289967 R 561276 CDS YP_002510364.1 221231212 7327512 complement(290225..290419) 1 NC_011900.1 DNA-binding protein 290419 7327512 SPN23F_03050 Streptococcus pneumoniae ATCC 700669 DNA-binding protein YP_002510364.1 290225 R 561276 CDS YP_002510365.1 221231213 7327513 290585..291535 1 NC_011900.1 S-adenosyl-methyltransferase MraW 291535 mraW 7327513 mraW Streptococcus pneumoniae ATCC 700669 S-adenosyl-methyltransferase MraW YP_002510365.1 290585 D 561276 CDS YP_002510366.1 221231214 7328131 291547..291864 1 NC_011900.1 cell division protein 291864 ftsL 7328131 ftsL Streptococcus pneumoniae ATCC 700669 cell division protein YP_002510366.1 291547 D 561276 CDS YP_002510367.1 221231215 7328570 291868..294120 1 NC_011900.1 penicillin binding protein 2x 294120 pbpX 7328570 pbpX Streptococcus pneumoniae ATCC 700669 penicillin binding protein 2x YP_002510367.1 291868 D 561276 CDS YP_002510368.1 221231216 7328456 294122..295102 1 NC_011900.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 295102 mraY 7328456 mraY Streptococcus pneumoniae ATCC 700669 phospho-N-acetylmuramoyl-pentapeptide- transferase YP_002510368.1 294122 D 561276 CDS YP_002510369.1 221231217 7328132 295711..297816 1 NC_011900.1 ATP-dependent protease ATP-binding subunit ClpL 297816 clpL 7328132 clpL Streptococcus pneumoniae ATCC 700669 ATP-dependent protease ATP-binding subunit ClpL YP_002510369.1 295711 D 561276 CDS YP_002510370.1 221231218 7329197 298252..298602 1 NC_011900.1 group II intron maturase 298602 7329197 SPN23F_03120 Streptococcus pneumoniae ATCC 700669 group II intron maturase YP_002510370.1 298252 D 561276 CDS YP_002510371.1 221231219 7329460 complement(298669..299151) 1 NC_011900.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase 299151 luxS 7329460 luxS Streptococcus pneumoniae ATCC 700669 S-ribosylhomocysteinase YP_002510371.1 298669 R 561276 CDS YP_002510372.1 221231220 7328112 complement(299246..300730) 1 NC_011900.1 hypothetical protein 300730 7328112 SPN23F_03140 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510372.1 299246 R 561276 CDS YP_002510373.1 221231221 7327515 300883..302490 1 NC_011900.1 glucan 1,6-alpha-glucosidase 302490 dexB 7327515 dexB Streptococcus pneumoniae ATCC 700669 glucan 1,6-alpha-glucosidase YP_002510373.1 300883 D 561276 CDS YP_002510374.1 221231222 7327516 303559..305004 1 NC_011900.1 capsule biosynthesis integral membrane regulatory protein Wzg 305004 wzg 7327516 wzg Streptococcus pneumoniae ATCC 700669 capsule biosynthesis integral membrane regulatory protein Wzg YP_002510374.1 303559 D 561276 CDS YP_002510375.1 221231223 7329442 305006..305737 1 NC_011900.1 capsule biosynthesis protein-tyrosine phosphatase Wzh 305737 wzh 7329442 wzh Streptococcus pneumoniae ATCC 700669 capsule biosynthesis protein-tyrosine phosphatase Wzh YP_002510375.1 305006 D 561276 CDS YP_002510376.1 221231224 7329443 305746..306438 1 NC_011900.1 capsule biosynthesis chain length determinant protein Wzd 306438 wzd 7329443 wzd Streptococcus pneumoniae ATCC 700669 capsule biosynthesis chain length determinant protein Wzd YP_002510376.1 305746 D 561276 CDS YP_002510377.1 221231225 7329440 306448..307137 1 NC_011900.1 capsule biosynthesis tyrosine-protein kinase Wze 307137 wze 7329440 wze Streptococcus pneumoniae ATCC 700669 capsule biosynthesis tyrosine-protein kinase Wze YP_002510377.1 306448 D 561276 CDS YP_002510378.1 221231226 7329441 307152..308519 1 NC_011900.1 UDP-phosphate glucose phosphotransferase 308519 wchA 7329441 wchA Streptococcus pneumoniae ATCC 700669 UDP-phosphate glucose phosphotransferase YP_002510378.1 307152 D 561276 CDS YP_002510379.1 221231227 7329432 308550..309728 1 NC_011900.1 rhamnosyl transferase WchF 309728 wchF 7329432 wchF Streptococcus pneumoniae ATCC 700669 rhamnosyl transferase WchF YP_002510379.1 308550 D 561276 CDS YP_002510380.1 221231228 7329433 310028..311221 1 NC_011900.1 oligosaccharide repeat unit polymerase Wzy 311221 wzy 7329433 wzy Streptococcus pneumoniae ATCC 700669 oligosaccharide repeat unit polymerase Wzy YP_002510380.1 310028 D 561276 CDS YP_002510381.1 221231229 7329445 311225..312196 1 NC_011900.1 glycosyltransferase WchA 312196 wchV 7329445 wchV Streptococcus pneumoniae ATCC 700669 glycosyltransferase WchA YP_002510381.1 311225 D 561276 CDS YP_002510382.1 221231230 7329434 312203..313435 1 NC_011900.1 glycosyltransferase WchW 313435 wchW 7329434 wchW Streptococcus pneumoniae ATCC 700669 glycosyltransferase WchW YP_002510382.1 312203 D 561276 CDS YP_002510383.1 221231231 7329435 313437..314822 1 NC_011900.1 capsule biosynthesis repeating unit flippase Wzx 314822 wzx 7329435 wzx Streptococcus pneumoniae ATCC 700669 capsule biosynthesis repeating unit flippase Wzx YP_002510383.1 313437 D 561276 CDS YP_002510384.1 221231232 7329444 314830..315978 1 NC_011900.1 glycerol phosphotransferase WchX 315978 wchX 7329444 wchX Streptococcus pneumoniae ATCC 700669 glycerol phosphotransferase WchX YP_002510384.1 314830 D 561276 CDS YP_002510385.1 221231233 7329436 316014..317042 1 NC_011900.1 glycerol-2-phosphate dehydrogenase WchY 317042 wchY 7329436 wchY Streptococcus pneumoniae ATCC 700669 glycerol-2-phosphate dehydrogenase WchY YP_002510385.1 316014 D 561276 CDS YP_002510386.1 221231234 7329437 317058..317762 1 NC_011900.1 nucleotidyl transferase WchZ 317762 wchZ 7329437 wchZ Streptococcus pneumoniae ATCC 700669 nucleotidyl transferase WchZ YP_002510386.1 317058 D 561276 CDS YP_002510387.1 221231235 7329438 317777..318610 1 NC_011900.1 phosphotransferase 318610 wciA 7329438 wciA Streptococcus pneumoniae ATCC 700669 phosphotransferase YP_002510387.1 317777 D 561276 CDS YP_002510388.1 221231236 7329439 318770..319639 1 NC_011900.1 glucose-1-phosphate thymidyl transferase RmlA 319639 rmlA 7329439 rmlA Streptococcus pneumoniae ATCC 700669 glucose-1-phosphate thymidyl transferase RmlA YP_002510388.1 318770 D 561276 CDS YP_002510389.1 221231237 7327459 319640..320233 1 NC_011900.1 dTDP-4-keto-6-deoxyglucose-3,5-epimerase RmlC 320233 rmlC 7327459 rmlC Streptococcus pneumoniae ATCC 700669 dTDP-4-keto-6-deoxyglucose-3,5-epimerase RmlC YP_002510389.1 319640 D 561276 CDS YP_002510390.1 221231238 7327461 320246..321295 1 NC_011900.1 dTDP-glucose-4,6-dehydratase RmlB 321295 rmlB 7327461 rmlB Streptococcus pneumoniae ATCC 700669 dTDP-glucose-4,6-dehydratase RmlB YP_002510390.1 320246 D 561276 CDS YP_002510391.1 221231239 7327460 321361..322212 1 NC_011900.1 dTDP-4-dehydrorhamnose reductase RmlD 322212 rmlD 7327460 rmlD Streptococcus pneumoniae ATCC 700669 dTDP-4-dehydrorhamnose reductase RmlD YP_002510391.1 321361 D 561276 CDS YP_002510392.1 221231240 7327517 323780..325762 1 NC_011900.1 extracellular oligopeptide-binding protein 325762 aliA 7327517 aliA Streptococcus pneumoniae ATCC 700669 extracellular oligopeptide-binding protein YP_002510392.1 323780 D 561276 CDS YP_002510393.1 221231241 7328646 326063..331366 1 NC_011900.1 cell wall surface anchored protein 331366 7328646 SPN23F_03400 Streptococcus pneumoniae ATCC 700669 cell wall surface anchored protein YP_002510393.1 326063 D 561276 CDS YP_002510394.1 221231242 7327518 complement(331533..333692) 1 NC_011900.1 penicillin-binding protein 1A 333692 pbp1A 7327518 pbp1A Streptococcus pneumoniae ATCC 700669 penicillin-binding protein 1A YP_002510394.1 331533 R 561276 CDS YP_002510395.1 221231243 7328453 complement(333689..334285) 1 NC_011900.1 functions in homologous recombination, DNA repair, and chromosome segregation; binds preferentially to three- and four-stranded DNA intermediates; introduces specific nick sites in four-stranded DNA substrates; functions similarly to Escherichia coli RuvC; Holliday junction-specific endonuclease 334285 recU 7328453 recU Streptococcus pneumoniae ATCC 700669 Holliday junction-specific endonuclease YP_002510395.1 333689 R 561276 CDS YP_002510396.1 221231244 7327448 334352..334879 1 NC_011900.1 hypothetical protein 334879 7327448 SPN23F_03430 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510396.1 334352 D 561276 CDS YP_002510397.1 221231245 7327519 334949..335290 1 NC_011900.1 DivIVA protein 335290 7327519 SPN23F_03440 Streptococcus pneumoniae ATCC 700669 DivIVA protein YP_002510397.1 334949 D 561276 CDS YP_002510398.1 221231246 7329461 335776..336933 1 NC_011900.1 RNA methylase family protein 336933 7329461 SPN23F_03450 Streptococcus pneumoniae ATCC 700669 RNA methylase family protein YP_002510398.1 335776 D 561276 CDS YP_002510399.1 221231247 7327521 336946..338340 1 NC_011900.1 hypothetical protein 338340 7327521 SPN23F_03460 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510399.1 336946 D 561276 CDS YP_002510400.1 221231248 7327522 338416..339840 1 NC_011900.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase 339840 gnd 7327522 gnd Streptococcus pneumoniae ATCC 700669 6-phosphogluconate dehydrogenase YP_002510400.1 338416 D 561276 CDS YP_002510401.1 221231249 7328617 339852..340541 1 NC_011900.1 response regulator protein 340541 csrR 7328617 csrR Streptococcus pneumoniae ATCC 700669 response regulator protein YP_002510401.1 339852 D 561276 CDS YP_002510402.1 221231250 7329215 340640..341638 1 NC_011900.1 choline binding protein J 341638 cbpJ 7329215 cbpJ Streptococcus pneumoniae ATCC 700669 choline binding protein J YP_002510402.1 340640 D 561276 CDS YP_002510403.1 221231251 7329185 complement(341756..342988) 1 NC_011900.1 Major Facilitator Superfamily protein 342988 7329185 SPN23F_03500 Streptococcus pneumoniae ATCC 700669 Major Facilitator Superfamily protein YP_002510403.1 341756 R 561276 CDS YP_002510404.1 221231252 7327525 344989..345867 1 NC_011900.1 mevalonate kinase 345867 mvaK1 7327525 mvaK1 Streptococcus pneumoniae ATCC 700669 mevalonate kinase YP_002510404.1 344989 D 561276 CDS YP_002510405.1 221231253 7328408 345849..346802 1 NC_011900.1 mevalonate diphosphate decarboxylase 346802 mvaD 7328408 mvaD Streptococcus pneumoniae ATCC 700669 mevalonate diphosphate decarboxylase YP_002510405.1 345849 D 561276 CDS YP_002510406.1 221231254 7328407 346789..347796 1 NC_011900.1 phosphomevalonate kinase 347796 mvaK2 7328407 mvaK2 Streptococcus pneumoniae ATCC 700669 phosphomevalonate kinase YP_002510406.1 346789 D 561276 CDS YP_002510407.1 221231255 7328409 347780..348790 1 NC_011900.1 catalyzes the isomerization of isopentenyl pyrophosphate to dimethylallyl diphosphate; isopentenyl pyrophosphate isomerase 348790 fni 7328409 fni Streptococcus pneumoniae ATCC 700669 isopentenyl pyrophosphate isomerase YP_002510407.1 347780 D 561276 CDS YP_002510408.1 221231256 7328557 348867..349565 1 NC_011900.1 hypothetical protein 349565 7328557 SPN23F_03570 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510408.1 348867 D 561276 CDS YP_002510409.1 221231257 7327526 349562..350557 1 NC_011900.1 sensor histidine kinase 350557 7327526 SPN23F_03580 Streptococcus pneumoniae ATCC 700669 sensor histidine kinase YP_002510409.1 349562 D 561276 CDS YP_002510410.1 221231258 7327527 350571..351203 1 NC_011900.1 response regulator protein 351203 7327527 SPN23F_03590 Streptococcus pneumoniae ATCC 700669 response regulator protein YP_002510410.1 350571 D 561276 CDS YP_002510411.1 221231259 7327529 352123..352362 1 NC_011900.1 hypothetical protein 352362 7327529 SPN23F_03630 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510411.1 352123 D 561276 CDS YP_002510412.1 221231260 7327530 352443..353264 1 NC_011900.1 choline binding protein G 353264 cbpG 7327530 cbpG Streptococcus pneumoniae ATCC 700669 choline binding protein G YP_002510412.1 352443 D 561276 CDS YP_002510413.1 221231261 7329184 353283..354305 1 NC_011900.1 choline binding protein F 354305 cbpF 7329184 cbpF Streptococcus pneumoniae ATCC 700669 choline binding protein F YP_002510413.1 353283 D 561276 CDS YP_002510414.1 221231262 7327532 355990..357759 1 NC_011900.1 mannitol-specific phosphotransferase system (PTS), IIBC component 357759 mtlA 7327532 mtlA Streptococcus pneumoniae ATCC 700669 mannitol-specific phosphotransferase system (PTS), IIBC component YP_002510414.1 355990 D 561276 CDS YP_002510415.1 221231263 7328383 357846..359738 1 NC_011900.1 transcriptional regulator 359738 mtlR 7328383 mtlR Streptococcus pneumoniae ATCC 700669 transcriptional regulator YP_002510415.1 357846 D 561276 CDS YP_002510416.1 221231264 7328386 359740..360177 1 NC_011900.1 mannitol-specific phosphotransferase system (PTS), IIA component 360177 mtlF 7328386 mtlF Streptococcus pneumoniae ATCC 700669 mannitol-specific phosphotransferase system (PTS), IIA component YP_002510416.1 359740 D 561276 CDS YP_002510417.1 221231265 7328385 360239..361375 1 NC_011900.1 mannitol-1-phosphate 5-dehydrogenase 361375 mtlD 7328385 mtlD Streptococcus pneumoniae ATCC 700669 mannitol-1-phosphate 5-dehydrogenase YP_002510417.1 360239 D 561276 CDS YP_002510418.1 221231266 7328384 361757..361870 1 NC_011900.1 hypothetical protein 361870 7328384 SPN23F_03750 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510418.1 361757 D 561276 CDS YP_002510419.1 221231267 7327533 362174..363457 1 NC_011900.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 363457 tig 7327533 tig Streptococcus pneumoniae ATCC 700669 trigger factor YP_002510419.1 362174 D 561276 CDS YP_002510420.1 221231268 7329176 complement(363505..365871) 1 NC_011900.1 hypothetical protein 365871 7329176 SPN23F_03770 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510420.1 363505 R 561276 CDS YP_002510421.1 221231269 7327534 complement(366150..366764) 1 NC_011900.1 signal peptidase I 366764 spi 7327534 spi Streptococcus pneumoniae ATCC 700669 signal peptidase I YP_002510421.1 366150 R 561276 CDS YP_002510422.1 221231270 7329150 complement(366776..367648) 1 NC_011900.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease HIII 367648 7329150 SPN23F_03800 Streptococcus pneumoniae ATCC 700669 ribonuclease HIII YP_002510422.1 366776 R 561276 CDS YP_002510423.1 221231271 7327535 367735..368037 1 NC_011900.1 hypothetical protein 368037 7327535 SPN23F_03810 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510423.1 367735 D 561276 CDS YP_002510424.1 221231272 7327536 368034..368582 1 NC_011900.1 bacteriocin production protein 368582 7327536 SPN23F_03820 Streptococcus pneumoniae ATCC 700669 bacteriocin production protein YP_002510424.1 368034 D 561276 CDS YP_002510425.1 221231273 7327537 368686..371022 1 NC_011900.1 DNA mismatch repair protein 371022 mutS2 7327537 mutS2 Streptococcus pneumoniae ATCC 700669 DNA mismatch repair protein YP_002510425.1 368686 D 561276 CDS YP_002510426.1 221231274 7329462 371365..372687 1 NC_011900.1 sodium:alanine symporter family protein 372687 7329462 SPN23F_03840 Streptococcus pneumoniae ATCC 700669 sodium:alanine symporter family protein YP_002510426.1 371365 D 561276 CDS YP_002510427.1 221231275 7327538 372905..373453 1 NC_011900.1 decarboxylase 373453 7327538 SPN23F_03850 Streptococcus pneumoniae ATCC 700669 decarboxylase YP_002510427.1 372905 D 561276 CDS YP_002510428.1 221231276 7327539 373563..374462 1 NC_011900.1 C4-dicarboxylate transporter 374462 7327539 SPN23F_03860 Streptococcus pneumoniae ATCC 700669 C4-dicarboxylate transporter YP_002510428.1 373563 D 561276 CDS YP_002510429.1 221231277 7327540 complement(374487..375761) 1 NC_011900.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 375761 serS 7327540 serS Streptococcus pneumoniae ATCC 700669 seryl-tRNA synthetase YP_002510429.1 374487 R 561276 CDS YP_002510430.1 221231278 7329143 complement(375975..376346) 1 NC_011900.1 hypothetical protein 376346 7329143 SPN23F_03880 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510430.1 375975 R 561276 CDS YP_002510431.1 221231279 7327541 complement(376349..377713) 1 NC_011900.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; lysine and threonine sensitive; aspartate kinase 377713 7327541 SPN23F_03890 Streptococcus pneumoniae ATCC 700669 aspartate kinase YP_002510431.1 376349 R 561276 CDS YP_002510432.1 221231280 7327542 378038..378823 1 NC_011900.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 378823 7327542 SPN23F_03900 Streptococcus pneumoniae ATCC 700669 enoyl-CoA hydratase YP_002510432.1 378038 D 561276 CDS YP_002510433.1 221231281 7327543 378917..379351 1 NC_011900.1 MarR family transcriptional regulator 379351 7327543 SPN23F_03910 Streptococcus pneumoniae ATCC 700669 MarR family transcriptional regulator YP_002510433.1 378917 D 561276 CDS YP_002510434.1 221231282 7327544 379351..380325 1 NC_011900.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-(acyl carrier protein) synthase III 380325 fabH 7327544 fabH Streptococcus pneumoniae ATCC 700669 3-oxoacyl-(acyl carrier protein) synthase III YP_002510434.1 379351 D 561276 CDS YP_002510435.1 221231283 7328548 380385..380609 1 NC_011900.1 carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 380609 acpP 7328548 acpP Streptococcus pneumoniae ATCC 700669 acyl carrier protein YP_002510435.1 380385 D 561276 CDS YP_002510436.1 221231284 7328631 380728..381702 1 NC_011900.1 enoyl-ACP reductase 381702 fabK 7328631 fabK Streptococcus pneumoniae ATCC 700669 enoyl-ACP reductase YP_002510436.1 380728 D 561276 CDS YP_002510437.1 221231285 7328549 381695..382615 1 NC_011900.1 malonyl CoA-acyl carrier protein transacylase 382615 fabD 7328549 fabD Streptococcus pneumoniae ATCC 700669 malonyl CoA-acyl carrier protein transacylase YP_002510437.1 381695 D 561276 CDS YP_002510438.1 221231286 7328544 382649..383380 1 NC_011900.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 383380 fabG 7328544 fabG Streptococcus pneumoniae ATCC 700669 3-ketoacyl-ACP reductase YP_002510438.1 382649 D 561276 CDS YP_002510439.1 221231287 7328547 383402..384637 1 NC_011900.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-(acyl carrier protein) synthase II 384637 fabF 7328547 fabF Streptococcus pneumoniae ATCC 700669 3-oxoacyl-(acyl carrier protein) synthase II YP_002510439.1 383402 D 561276 CDS YP_002510440.1 221231288 7328546 384640..385125 1 NC_011900.1 composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 385125 fabE 7328546 fabE Streptococcus pneumoniae ATCC 700669 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit YP_002510440.1 384640 D 561276 CDS YP_002510441.1 221231289 7328545 385122..385544 1 NC_011900.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 385544 fabZ 7328545 fabZ Streptococcus pneumoniae ATCC 700669 (3R)-hydroxymyristoyl-ACP dehydratase YP_002510441.1 385122 D 561276 CDS YP_002510442.1 221231290 7328550 385556..386923 1 NC_011900.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxylase subunit 386923 accC 7328550 accC Streptococcus pneumoniae ATCC 700669 acetyl-CoA carboxylase biotin carboxylase subunit YP_002510442.1 385556 D 561276 CDS YP_002510443.1 221231291 7328626 386960..387826 1 NC_011900.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta 387826 accD 7328626 accD Streptococcus pneumoniae ATCC 700669 acetyl-CoA carboxylase subunit beta YP_002510443.1 386960 D 561276 CDS YP_002510444.1 221231292 7328627 387823..388590 1 NC_011900.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; these proteins present a shorter N-terminus; acetyl-CoA carboxylase subunit alpha 388590 accA 7328627 accA Streptococcus pneumoniae ATCC 700669 acetyl-CoA carboxylase subunit alpha YP_002510444.1 387823 D 561276 CDS YP_002510445.1 221231293 7328625 388853..389038 1 NC_011900.1 hypothetical protein 389038 7328625 SPN23F_04030 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510445.1 388853 D 561276 CDS YP_002510446.1 221231294 7327545 389056..389346 1 NC_011900.1 hypothetical protein 389346 7327545 SPN23F_04040 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510446.1 389056 D 561276 CDS YP_002510447.1 221231295 7327546 389401..389778 1 NC_011900.1 hypothetical protein 389778 7327546 SPN23F_04050 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510447.1 389401 D 561276 CDS YP_002510448.1 221231296 7327547 complement(389825..390247) 1 NC_011900.1 Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 390247 nusB 7327547 nusB Streptococcus pneumoniae ATCC 700669 transcription antitermination protein NusB YP_002510448.1 389825 R 561276 CDS YP_002510449.1 221231297 7328434 complement(390240..390629) 1 NC_011900.1 hypothetical protein 390629 7328434 SPN23F_04070 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510449.1 390240 R 561276 CDS YP_002510450.1 221231298 7327548 complement(390651..391211) 1 NC_011900.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 391211 efp 7327548 efp Streptococcus pneumoniae ATCC 700669 elongation factor P YP_002510450.1 390651 R 561276 CDS YP_002510451.1 221231299 7329251 complement(391340..392782) 1 NC_011900.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit B 392782 gatB 7329251 gatB Streptococcus pneumoniae ATCC 700669 aspartyl/glutamyl-tRNA amidotransferase subunit B YP_002510451.1 391340 R 561276 CDS YP_002510452.1 221231300 7328587 complement(392782..394248) 1 NC_011900.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A 394248 gatA 7328587 gatA Streptococcus pneumoniae ATCC 700669 aspartyl/glutamyl-tRNA amidotransferase subunit A YP_002510452.1 392782 R 561276 CDS YP_002510453.1 221231301 7328586 complement(394248..394550) 1 NC_011900.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain; aspartyl/glutamyl-tRNA amidotransferase subunit C 394550 gatC 7328586 gatC Streptococcus pneumoniae ATCC 700669 aspartyl/glutamyl-tRNA amidotransferase subunit C YP_002510453.1 394248 R 561276 CDS YP_002510454.1 221231302 7328588 394763..396307 1 NC_011900.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 396307 prfC 7328588 prfC Streptococcus pneumoniae ATCC 700669 peptide chain release factor 3 YP_002510454.1 394763 D 561276 CDS YP_002510455.1 221231303 7327874 396576..397061 1 NC_011900.1 glycosyl transferase 397061 7327874 SPN23F_04130 Streptococcus pneumoniae ATCC 700669 glycosyl transferase YP_002510455.1 396576 D 561276 CDS YP_002510456.1 221231304 7327549 397177..397365 1 NC_011900.1 required for 70S ribosome assembly; 50S ribosomal protein L28 397365 rpmB 7327549 rpmB Streptococcus pneumoniae ATCC 700669 50S ribosomal protein L28 YP_002510456.1 397177 D 561276 CDS YP_002510457.1 221231305 7327493 397522..397887 1 NC_011900.1 hypothetical protein 397887 7327493 SPN23F_04150 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510457.1 397522 D 561276 CDS YP_002510458.1 221231306 7327550 397890..399557 1 NC_011900.1 phosphatase 399557 7327550 SPN23F_04160 Streptococcus pneumoniae ATCC 700669 phosphatase YP_002510458.1 397890 D 561276 CDS YP_002510459.1 221231307 7327551 399757..401457 1 NC_011900.1 catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; acetolactate synthase catalytic subunit 401457 alsS 7327551 alsS Streptococcus pneumoniae ATCC 700669 acetolactate synthase catalytic subunit YP_002510459.1 399757 D 561276 CDS YP_002510460.1 221231308 7328649 401450..401926 1 NC_011900.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 401926 ilvH 7328649 ilvH Streptococcus pneumoniae ATCC 700669 acetolactate synthase 3 regulatory subunit YP_002510460.1 401450 D 561276 CDS YP_002510461.1 221231309 7328084 401992..403014 1 NC_011900.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 403014 ilvC 7328084 ilvC Streptococcus pneumoniae ATCC 700669 ketol-acid reductoisomerase YP_002510461.1 401992 D 561276 CDS YP_002510462.1 221231310 7327552 403595..403951 1 NC_011900.1 hypothetical protein 403951 7327552 SPN23F_04210 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510462.1 403595 D 561276 CDS YP_002510463.1 221231311 7327553 404001..405251 1 NC_011900.1 catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic; threonine dehydratase 405251 ilvA 7327553 ilvA Streptococcus pneumoniae ATCC 700669 threonine dehydratase YP_002510463.1 404001 D 561276 CDS YP_002510464.1 221231312 7328081 406122..406337 1 NC_011900.1 hypothetical protein 406337 7328081 SPN23F_04240 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510464.1 406122 D 561276 CDS YP_002510465.1 221231313 7327554 complement(406446..407186) 1 NC_011900.1 glutamine ABC transporter,ATP-binding protein 2 407186 glnQ2 7327554 glnQ2 Streptococcus pneumoniae ATCC 700669 glutamine ABC transporter,ATP-binding protein 2 YP_002510465.1 406446 R 561276 CDS YP_002510466.1 221231314 7328604 complement(407186..408751) 1 NC_011900.1 glutamine ABC transporter, glutamine-binding protein/permease protein 408751 7328604 SPN23F_04260 Streptococcus pneumoniae ATCC 700669 glutamine ABC transporter, glutamine-binding protein/permease protein YP_002510466.1 407186 R 561276 CDS YP_002510467.1 221231315 7327555 408889..410778 1 NC_011900.1 hypothetical protein 410778 7327555 SPN23F_04270 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510467.1 408889 D 561276 CDS YP_002510468.1 221231316 7327557 412203..413048 1 NC_011900.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; UDP pyrophosphate phosphatase 413048 bacA 7327557 bacA Streptococcus pneumoniae ATCC 700669 UDP pyrophosphate phosphatase YP_002510468.1 412203 D 561276 CDS YP_002510469.1 221231317 7328680 complement(413195..414256) 1 NC_011900.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 414256 dinB 7328680 dinB Streptococcus pneumoniae ATCC 700669 DNA polymerase IV YP_002510469.1 413195 R 561276 CDS YP_002510470.1 221231318 7329231 414604..416928 1 NC_011900.1 formate acetyltransferase 416928 pfl 7329231 pfl Streptococcus pneumoniae ATCC 700669 formate acetyltransferase YP_002510470.1 414604 D 561276 CDS YP_002510471.1 221231319 7327834 complement(417295..417513) 1 NC_011900.1 hypothetical protein 417513 7327834 SPN23F_04330 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510471.1 417295 R 561276 CDS YP_002510472.1 221231320 7327558 complement(417840..418124) 1 NC_011900.1 hypothetical protein 418124 7327558 SPN23F_04340 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510472.1 417840 R 561276 CDS YP_002510473.1 221231321 7327560 complement(420048..421475) 1 NC_011900.1 cation transport protein 421475 7327560 SPN23F_04360 Streptococcus pneumoniae ATCC 700669 cation transport protein YP_002510473.1 420048 R 561276 CDS YP_002510474.1 221231322 7327561 complement(421491..422840) 1 NC_011900.1 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane component 422840 trkA 7327561 trkA Streptococcus pneumoniae ATCC 700669 potassium transporter peripheral membrane component YP_002510474.1 421491 R 561276 CDS YP_002510475.1 221231323 7327562 423028..423876 1 NC_011900.1 hypothetical protein 423876 7327562 SPN23F_04380 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510475.1 423028 D 561276 CDS YP_002510476.1 221231324 7327563 423891..424439 1 NC_011900.1 hypothetical protein 424439 7327563 SPN23F_04390 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510476.1 423891 D 561276 CDS YP_002510477.1 221231325 7327564 424446..424703 1 NC_011900.1 hypothetical protein 424703 7327564 SPN23F_04400 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510477.1 424446 D 561276 CDS YP_002510478.1 221231326 7327565 424805..426487 1 NC_011900.1 ABC transporter ATP-binding protein 426487 7327565 SPN23F_04410 Streptococcus pneumoniae ATCC 700669 ABC transporter ATP-binding protein YP_002510478.1 424805 D 561276 CDS YP_002510479.1 221231327 7327566 426472..427302 1 NC_011900.1 transport protein 427302 7327566 SPN23F_04420 Streptococcus pneumoniae ATCC 700669 transport protein YP_002510479.1 426472 D 561276 CDS YP_002510480.1 221231328 7327567 427495..427998 1 NC_011900.1 SpoU rRNA methylase family protein 427998 7327567 SPN23F_04430 Streptococcus pneumoniae ATCC 700669 SpoU rRNA methylase family protein YP_002510480.1 427495 D 561276 CDS YP_002510481.1 221231329 7329463 428451..429014 1 NC_011900.1 hypothetical protein 429014 7329463 SPN23F_04440 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510481.1 428451 D 561276 CDS YP_002510482.1 221231330 7327569 429004..429654 1 NC_011900.1 PAP2 superfamily protein 429654 7327569 SPN23F_04450 Streptococcus pneumoniae ATCC 700669 PAP2 superfamily protein YP_002510482.1 429004 D 561276 CDS YP_002510483.1 221231331 7327570 429682..430071 1 NC_011900.1 hypothetical protein 430071 7327570 SPN23F_04460 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510483.1 429682 D 561276 CDS YP_002510484.1 221231332 7327571 430076..430525 1 NC_011900.1 GNAT family acetyltransferase 430525 7327571 SPN23F_04470 Streptococcus pneumoniae ATCC 700669 GNAT family acetyltransferase YP_002510484.1 430076 D 561276 CDS YP_002510485.1 221231333 7327572 430653..431240 1 NC_011900.1 participates in both the initiation and recycling phases of transcription; in the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling; DNA-directed RNA polymerase subunit delta 431240 rpoE 7327572 rpoE Streptococcus pneumoniae ATCC 700669 DNA-directed RNA polymerase subunit delta YP_002510485.1 430653 D 561276 CDS YP_002510486.1 221231334 7329107 431630..433237 1 NC_011900.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 433237 pyrG 7329107 pyrG Streptococcus pneumoniae ATCC 700669 CTP synthetase YP_002510486.1 431630 D 561276 CDS YP_002510487.1 221231335 7327434 complement(433796..435427) 1 NC_011900.1 Na+/Pi-cotransporter protein 435427 7327434 SPN23F_04510 Streptococcus pneumoniae ATCC 700669 Na+/Pi-cotransporter protein YP_002510487.1 433796 R 561276 CDS YP_002510488.1 221231336 7327573 435720..440630 1 NC_011900.1 endo-beta-N-acetylglucosaminidase 440630 7327573 SPN23F_04520 Streptococcus pneumoniae ATCC 700669 endo-beta-N-acetylglucosaminidase YP_002510488.1 435720 D 561276 CDS YP_002510489.1 221231337 7327574 440720..441916 1 NC_011900.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 441916 pgk 7327574 pgk Streptococcus pneumoniae ATCC 700669 phosphoglycerate kinase YP_002510489.1 440720 D 561276 CDS YP_002510490.1 221231338 7327838 442052..442579 1 NC_011900.1 hypothetical protein 442579 7327838 SPN23F_04540 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510490.1 442052 D 561276 CDS YP_002510491.1 221231339 7327575 442656..443012 1 NC_011900.1 MerR family transcriptional regulator 443012 glnR 7327575 glnR Streptococcus pneumoniae ATCC 700669 MerR family transcriptional regulator YP_002510491.1 442656 D 561276 CDS YP_002510492.1 221231340 7328606 443049..444395 1 NC_011900.1 glutamine synthetase 444395 glnA 7328606 glnA Streptococcus pneumoniae ATCC 700669 glutamine synthetase YP_002510492.1 443049 D 561276 CDS YP_002510493.1 221231341 7328602 445191..446471 1 NC_011900.1 type I restriction-modification system S protein 446471 7328602 SPN23F_04590 Streptococcus pneumoniae ATCC 700669 type I restriction-modification system S protein YP_002510493.1 445191 D 561276 CDS YP_002510494.1 221231342 7327576 complement(446419..447027) 1 NC_011900.1 type I restriction-modification system S protein 447027 7327576 SPN23F_04591 Streptococcus pneumoniae ATCC 700669 type I restriction-modification system S protein YP_002510494.1 446419 R 561276 CDS YP_002510495.1 221231343 7327577 complement(447038..447835) 1 NC_011900.1 phage integrase/recombinase 447835 7327577 SPN23F_04600 Streptococcus pneumoniae ATCC 700669 phage integrase/recombinase YP_002510495.1 447038 R 561276 CDS YP_002510496.1 221231344 7327578 complement(447892..449442) 1 NC_011900.1 type I restriction-modification system S protein 449442 7327578 SPN23F_04610 Streptococcus pneumoniae ATCC 700669 type I restriction-modification system S protein YP_002510496.1 447892 R 561276 CDS YP_002510497.1 221231345 7329340 complement(449442..450905) 1 NC_011900.1 type I restriction-modification system M protein 450905 7329340 SPN23F_04620 Streptococcus pneumoniae ATCC 700669 type I restriction-modification system M protein YP_002510497.1 449442 R 561276 CDS YP_002510498.1 221231346 7328142 complement(450918..453251) 1 NC_011900.1 type I restriction-modification system R protein 453251 7328142 SPN23F_04630 Streptococcus pneumoniae ATCC 700669 type I restriction-modification system R protein YP_002510498.1 450918 R 561276 CDS YP_002510499.1 221231347 7328143 453624..453824 1 NC_011900.1 hypothetical protein 453824 7328143 SPN23F_04640 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510499.1 453624 D 561276 CDS YP_002510500.1 221231348 7328144 453859..454368 1 NC_011900.1 hypothetical protein 454368 7328144 SPN23F_04650 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510500.1 453859 D 561276 CDS YP_002510501.1 221231349 7328145 454532..455566 1 NC_011900.1 Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons; heat-inducible transcription repressor 455566 hrcA 7328145 hrcA Streptococcus pneumoniae ATCC 700669 heat-inducible transcription repressor YP_002510501.1 454532 D 561276 CDS YP_002510502.1 221231350 7328076 455593..456117 1 NC_011900.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 456117 grpE 7328076 grpE Streptococcus pneumoniae ATCC 700669 heat shock protein GrpE YP_002510502.1 455593 D 561276 CDS YP_002510503.1 221231351 7328062 456597..458420 1 NC_011900.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 458420 dnaK 7328062 dnaK Streptococcus pneumoniae ATCC 700669 molecular chaperone DnaK YP_002510503.1 456597 D 561276 CDS YP_002510504.1 221231352 7329245 458422..458778 1 NC_011900.1 hypothetical protein 458778 7329245 SPN23F_04690 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510504.1 458422 D 561276 CDS YP_002510505.1 221231353 7328146 459180..460316 1 NC_011900.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ 460316 dnaJ 7328146 dnaJ Streptococcus pneumoniae ATCC 700669 chaperone protein DnaJ YP_002510505.1 459180 D 561276 CDS YP_002510506.1 221231354 7329244 complement(460628..460819) 1 NC_011900.1 hypothetical protein 460819 7329244 SPN23F_04710 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510506.1 460628 R 561276 CDS YP_002510507.1 221231355 7328147 complement(461074..461361) 1 NC_011900.1 hypothetical protein 461361 7328147 SPN23F_04720 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510507.1 461074 R 561276 CDS YP_002510508.1 221231356 7328148 complement(461371..461781) 1 NC_011900.1 HIT-family nucleotide-binding protein 461781 7328148 SPN23F_04730 Streptococcus pneumoniae ATCC 700669 HIT-family nucleotide-binding protein YP_002510508.1 461371 R 561276 CDS YP_002510509.1 221231357 7328149 461849..462580 1 NC_011900.1 ABC transporter ATP-binding protein 462580 7328149 SPN23F_04740 Streptococcus pneumoniae ATCC 700669 ABC transporter ATP-binding protein YP_002510509.1 461849 D 561276 CDS YP_002510510.1 221231358 7328150 462577..463626 1 NC_011900.1 ABC transporter 463626 7328150 SPN23F_04750 Streptococcus pneumoniae ATCC 700669 ABC transporter YP_002510510.1 462577 D 561276 CDS YP_002510511.1 221231359 7328151 complement(463794..464123) 1 NC_011900.1 hypothetical protein 464123 7328151 SPN23F_04760 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510511.1 463794 R 561276 CDS YP_002510512.1 221231360 7328152 464399..464737 1 NC_011900.1 regulatory protein BlpS 464737 blpS 7328152 blpS Streptococcus pneumoniae ATCC 700669 regulatory protein BlpS YP_002510512.1 464399 D 561276 CDS YP_002510513.1 221231361 7328694 464742..465479 1 NC_011900.1 response regulator protein BlpR 465479 blpR 7328694 blpR Streptococcus pneumoniae ATCC 700669 response regulator protein BlpR YP_002510513.1 464742 D 561276 CDS YP_002510514.1 221231362 7328693 465493..466833 1 NC_011900.1 sensor histidine kinase BlpH 466833 blpH 7328693 blpH Streptococcus pneumoniae ATCC 700669 sensor histidine kinase BlpH YP_002510514.1 465493 D 561276 CDS YP_002510515.1 221231363 7328687 complement(466904..467032) 1 NC_011900.1 peptide pheromone BlpC (bacteriocin-like peptide) 467032 blpC 7328687 blpC Streptococcus pneumoniae ATCC 700669 peptide pheromone BlpC (bacteriocin-like peptide) YP_002510515.1 466904 R 561276 CDS YP_002510516.1 221231364 7328686 complement(467089..468450) 1 NC_011900.1 ABC transporter 468450 blpB 7328686 blpB Streptococcus pneumoniae ATCC 700669 ABC transporter YP_002510516.1 467089 R 561276 CDS YP_002510517.1 221231365 7328685 complement(468461..470014) 1 NC_011900.1 bacteriocin transport/processing ATP-binding protein BlpA 470014 blpA1 7328685 blpA1 Streptococcus pneumoniae ATCC 700669 bacteriocin transport/processing ATP-binding protein BlpA YP_002510517.1 468461 R 561276 CDS YP_002510518.1 221231366 7328683 complement(470031..470618) 1 NC_011900.1 bacteriocin transporter C39 protease domain BlpA2 470618 blpA2 7328683 blpA2 Streptococcus pneumoniae ATCC 700669 bacteriocin transporter C39 protease domain BlpA2 YP_002510518.1 470031 R 561276 CDS YP_002510519.1 221231367 7328684 470900..471097 1 NC_011900.1 bacteriocin BlpI 471097 blpI 7328684 blpI Streptococcus pneumoniae ATCC 700669 bacteriocin BlpI YP_002510519.1 470900 D 561276 CDS YP_002510520.1 221231368 7328688 471102..471263 1 NC_011900.1 immunity protein PncB 471263 pncB 7328688 pncB Streptococcus pneumoniae ATCC 700669 immunity protein PncB YP_002510520.1 471102 D 561276 CDS YP_002510521.1 221231369 7327856 471268..471417 1 NC_011900.1 hypothetical protein 471417 pncC 7327856 pncC Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510521.1 471268 D 561276 CDS YP_002510522.1 221231370 7327857 471564..471833 1 NC_011900.1 bacteriocin BlpJ 471833 blpJ 7327857 blpJ Streptococcus pneumoniae ATCC 700669 bacteriocin BlpJ YP_002510522.1 471564 D 561276 CDS YP_002510523.1 221231371 7328689 471902..472150 1 NC_011900.1 bacteriocin BlpK 472150 blpK 7328689 blpK Streptococcus pneumoniae ATCC 700669 bacteriocin BlpK YP_002510523.1 471902 D 561276 CDS YP_002510524.1 221231372 7328690 472169..472378 1 NC_011900.1 immunity protein PncK 472378 pncK 7328690 pncK Streptococcus pneumoniae ATCC 700669 immunity protein PncK YP_002510524.1 472169 D 561276 CDS YP_002510525.1 221231373 7328154 472647..472766 1 NC_011900.1 pncF 472766 7328154 SPN23F_04880 Streptococcus pneumoniae ATCC 700669 pncF YP_002510525.1 472647 D 561276 CDS YP_002510526.1 221231374 7328155 472879..472995 1 NC_011900.1 hypothetical protein 472995 7328155 SPN23F_04890 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510526.1 472879 D 561276 CDS YP_002510527.1 221231375 7328156 473063..473224 1 NC_011900.1 immunity protein 473224 pncG 7328156 pncG Streptococcus pneumoniae ATCC 700669 immunity protein YP_002510527.1 473063 D 561276 CDS YP_002510528.1 221231376 7327858 473234..473605 1 NC_011900.1 hypothetical protein 473605 blpL 7327858 blpL Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510528.1 473234 D 561276 CDS YP_002510529.1 221231377 7328691 473783..473962 1 NC_011900.1 immunity protein PncM 473962 pncM 7328691 pncM Streptococcus pneumoniae ATCC 700669 immunity protein PncM YP_002510529.1 473783 D 561276 CDS YP_002510530.1 221231378 7327860 473994..474134 1 NC_011900.1 hypothetical protein 474134 7327860 SPN23F_04920 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510530.1 473994 D 561276 CDS YP_002510531.1 221231379 7328157 474234..474617 1 NC_011900.1 immunity protein BlpX 474617 blpX 7328157 blpX Streptococcus pneumoniae ATCC 700669 immunity protein BlpX YP_002510531.1 474234 D 561276 CDS YP_002510532.1 221231380 7328695 474669..475358 1 NC_011900.1 bacteeriocin ABC transporter transmembrane domain BlpY (CAAX protease) 475358 blpY 7328695 blpY Streptococcus pneumoniae ATCC 700669 bacteeriocin ABC transporter transmembrane domain BlpY (CAAX protease) YP_002510532.1 474669 D 561276 CDS YP_002510533.1 221231381 7328696 475400..475633 1 NC_011900.1 immunity protein BlpZ 475633 blpZ 7328696 blpZ Streptococcus pneumoniae ATCC 700669 immunity protein BlpZ YP_002510533.1 475400 D 561276 CDS YP_002510534.1 221231382 7328697 475784..476395 1 NC_011900.1 ABC transporter ATP-binding protein 476395 pncP 7328697 pncP Streptococcus pneumoniae ATCC 700669 ABC transporter ATP-binding protein YP_002510534.1 475784 D 561276 CDS YP_002510535.1 221231383 7327861 476556..477350 1 NC_011900.1 phosphotransferase 477350 7327861 SPN23F_04960 Streptococcus pneumoniae ATCC 700669 phosphotransferase YP_002510535.1 476556 D 561276 CDS YP_002510536.1 221231384 7328158 477347..477982 1 NC_011900.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 477982 trmB 7328158 trmB Streptococcus pneumoniae ATCC 700669 tRNA (guanine-N(7)-)-methyltransferase YP_002510536.1 477347 D 561276 CDS YP_002510537.1 221231385 7328159 478108..478587 1 NC_011900.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein 478587 7328159 SPN23F_04980 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510537.1 478108 D 561276 CDS YP_002510538.1 221231386 7328160 478631..479767 1 NC_011900.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 479767 nusA 7328160 nusA Streptococcus pneumoniae ATCC 700669 transcription elongation factor NusA YP_002510538.1 478631 D 561276 CDS YP_002510539.1 221231387 7328433 479789..480082 1 NC_011900.1 hypothetical protein 480082 7328433 SPN23F_05000 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510539.1 479789 D 561276 CDS YP_002510540.1 221231388 7328161 480075..480374 1 NC_011900.1 hypothetical protein 480374 7328161 SPN23F_05010 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510540.1 480075 D 561276 CDS YP_002510541.1 221231389 7328162 480391..483183 1 NC_011900.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 483183 infB 7328162 infB Streptococcus pneumoniae ATCC 700669 translation initiation factor IF-2 YP_002510541.1 480391 D 561276 CDS YP_002510542.1 221231390 7328086 483434..483784 1 NC_011900.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A 483784 rbfA 7328086 rbfA Streptococcus pneumoniae ATCC 700669 ribosome-binding factor A YP_002510542.1 483434 D 561276 CDS YP_002510543.1 221231391 7327441 484063..484842 1 NC_011900.1 hypothetical protein 484842 7327441 SPN23F_05040 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510543.1 484063 D 561276 CDS YP_002510544.1 221231392 7328163 484844..485026 1 NC_011900.1 hypothetical protein 485026 7328163 SPN23F_05050 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510544.1 484844 D 561276 CDS YP_002510545.1 221231393 7328164 complement(485304..485546) 1 NC_011900.1 hypothetical protein 485546 7328164 SPN23F_05060 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510545.1 485304 R 561276 CDS YP_002510546.1 221231394 7328165 485577..485810 1 NC_011900.1 hypothetical protein 485810 7328165 SPN23F_05070 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510546.1 485577 D 561276 CDS YP_002510547.1 221231395 7328166 485810..487144 1 NC_011900.1 hypothetical protein 487144 7328166 SPN23F_05080 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510547.1 485810 D 561276 CDS YP_002510548.1 221231396 7328167 487154..487408 1 NC_011900.1 hypothetical protein 487408 7328167 SPN23F_05090 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510548.1 487154 D 561276 CDS YP_002510549.1 221231397 7328168 487504..487899 1 NC_011900.1 hypothetical protein 487899 7328168 SPN23F_05100 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510549.1 487504 D 561276 CDS YP_002510550.1 221231398 7328169 488312..488761 1 NC_011900.1 hypothetical protein 488761 7328169 SPN23F_05110 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510550.1 488312 D 561276 CDS YP_002510551.1 221231399 7328170 488748..489305 1 NC_011900.1 acetyltransferase 489305 7328170 SPN23F_05120 Streptococcus pneumoniae ATCC 700669 acetyltransferase YP_002510551.1 488748 D 561276 CDS YP_002510552.1 221231400 7328171 489307..490269 1 NC_011900.1 hypothetical protein 490269 7328171 SPN23F_05130 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510552.1 489307 D 561276 CDS YP_002510553.1 221231401 7328172 490281..492932 1 NC_011900.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 492932 valS 7328172 valS Streptococcus pneumoniae ATCC 700669 valyl-tRNA synthetase YP_002510553.1 490281 D 561276 CDS YP_002510554.1 221231402 7329426 493002..493757 1 NC_011900.1 hypothetical protein 493757 7329426 SPN23F_05150 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510554.1 493002 D 561276 CDS YP_002510555.1 221231403 7328173 494038..494841 1 NC_011900.1 cell filamentation protein fic-related protein 494841 7328173 SPN23F_05151 Streptococcus pneumoniae ATCC 700669 cell filamentation protein fic-related protein YP_002510555.1 494038 D 561276 CDS YP_002510556.1 221231404 7328176 496704..499262 1 NC_011900.1 type III restriction endonuclease 499262 7328176 SPN23F_05190 Streptococcus pneumoniae ATCC 700669 type III restriction endonuclease YP_002510556.1 496704 D 561276 CDS YP_002510557.1 221231405 7328177 499562..500401 1 NC_011900.1 transcription antiterminator 500401 7328177 SPN23F_05200 Streptococcus pneumoniae ATCC 700669 transcription antiterminator YP_002510557.1 499562 D 561276 CDS YP_002510558.1 221231406 7328178 500419..502257 1 NC_011900.1 beta-glucoside-specific phosphotransferase system (PTS), IIABC component 502257 7328178 SPN23F_05210 Streptococcus pneumoniae ATCC 700669 beta-glucoside-specific phosphotransferase system (PTS), IIABC component YP_002510558.1 500419 D 561276 CDS YP_002510559.1 221231407 7328179 502270..503685 1 NC_011900.1 6-phospho-beta-glucosidase 503685 7328179 SPN23F_05220 Streptococcus pneumoniae ATCC 700669 6-phospho-beta-glucosidase YP_002510559.1 502270 D 561276 CDS YP_002510560.1 221231408 7328180 504196..505323 1 NC_011900.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 505323 pheS 7328180 pheS Streptococcus pneumoniae ATCC 700669 phenylalanyl-tRNA synthetase subunit alpha YP_002510560.1 504196 D 561276 CDS YP_002510561.1 221231409 7327842 505323..505832 1 NC_011900.1 GNAT family acetyltransferase 505832 7327842 SPN23F_05240 Streptococcus pneumoniae ATCC 700669 GNAT family acetyltransferase YP_002510561.1 505323 D 561276 CDS YP_002510562.1 221231410 7328181 505909..508311 1 NC_011900.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 508311 pheT 7328181 pheT Streptococcus pneumoniae ATCC 700669 phenylalanyl-tRNA synthetase subunit beta YP_002510562.1 505909 D 561276 CDS YP_002510563.1 221231411 7327843 complement(508379..509380) 1 NC_011900.1 integral membrane protein 509380 7327843 SPN23F_05260 Streptococcus pneumoniae ATCC 700669 integral membrane protein YP_002510563.1 508379 R 561276 CDS YP_002510564.1 221231412 7328183 510108..510374 1 NC_011900.1 hypothetical protein 510374 7328183 SPN23F_05280 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510564.1 510108 D 561276 CDS YP_002510565.1 221231413 7328184 510635..512884 1 NC_011900.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase 512884 metE 7328184 metE Streptococcus pneumoniae ATCC 700669 5-methyltetrahydropteroyltriglutamate-- homocysteine methyltransferase YP_002510565.1 510635 D 561276 CDS YP_002510566.1 221231414 7328126 512948..513814 1 NC_011900.1 5,10-methylenetetrahydrofolate reductase 513814 metF 7328126 metF Streptococcus pneumoniae ATCC 700669 5,10-methylenetetrahydrofolate reductase YP_002510566.1 512948 D 561276 CDS YP_002510567.1 221231415 7328127 514499..516712 1 NC_011900.1 polynucleotide phosphorylase/polyadenylase 516712 pnpA 7328127 pnpA Streptococcus pneumoniae ATCC 700669 polynucleotide phosphorylase/polyadenylase YP_002510567.1 514499 D 561276 CDS YP_002510568.1 221231416 7327862 516728..517345 1 NC_011900.1 serine acetyltransferase 517345 cysE 7327862 cysE Streptococcus pneumoniae ATCC 700669 serine acetyltransferase YP_002510568.1 516728 D 561276 CDS YP_002510569.1 221231417 7329218 517357..518241 1 NC_011900.1 GNAT family acetyltransferase 518241 7329218 SPN23F_05330 Streptococcus pneumoniae ATCC 700669 GNAT family acetyltransferase YP_002510569.1 517357 D 561276 CDS YP_002510570.1 221231418 7328185 518328..519671 1 NC_011900.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 519671 cysS 7328185 cysS Streptococcus pneumoniae ATCC 700669 cysteinyl-tRNA synthetase YP_002510570.1 518328 D 561276 CDS YP_002510571.1 221231419 7329220 519664..520050 1 NC_011900.1 ribomuclease 520050 7329220 SPN23F_05350 Streptococcus pneumoniae ATCC 700669 ribomuclease YP_002510571.1 519664 D 561276 CDS YP_002510572.1 221231420 7328186 520054..520938 1 NC_011900.1 leucine-rich protein 520938 7328186 SPN23F_05360 Streptococcus pneumoniae ATCC 700669 leucine-rich protein YP_002510572.1 520054 D 561276 CDS YP_002510573.1 221231421 7328187 complement(520985..522241) 1 NC_011900.1 IS1167A transposase 522241 7328187 SPN23F_05370 Streptococcus pneumoniae ATCC 700669 IS1167A transposase YP_002510573.1 520985 R 561276 CDS YP_002510574.1 221231422 7328188 522604..523203 1 NC_011900.1 hypothetical protein 523203 7328188 SPN23F_05380 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510574.1 522604 D 561276 CDS YP_002510575.1 221231423 7329464 523873..525150 1 NC_011900.1 ABC transporter permease 525150 7329464 SPN23F_05400 Streptococcus pneumoniae ATCC 700669 ABC transporter permease YP_002510575.1 523873 D 561276 CDS YP_002510576.1 221231424 7328191 525163..525810 1 NC_011900.1 ABC transporter ATP-binding protein 525810 7328191 SPN23F_05410 Streptococcus pneumoniae ATCC 700669 ABC transporter ATP-binding protein YP_002510576.1 525163 D 561276 CDS YP_002510577.1 221231425 7328192 525862..527241 1 NC_011900.1 ABC transporter permease 527241 7328192 SPN23F_05420 Streptococcus pneumoniae ATCC 700669 ABC transporter permease YP_002510577.1 525862 D 561276 CDS YP_002510578.1 221231426 7328193 527553..528209 1 NC_011900.1 two-component system, response regulator 528209 7328193 SPN23F_05430 Streptococcus pneumoniae ATCC 700669 two-component system, response regulator YP_002510578.1 527553 D 561276 CDS YP_002510579.1 221231427 7328194 528206..529534 1 NC_011900.1 two-component system, sensor histidine kinase 529534 7328194 SPN23F_05440 Streptococcus pneumoniae ATCC 700669 two-component system, sensor histidine kinase YP_002510579.1 528206 D 561276 CDS YP_002510580.1 221231428 7328195 529675..530556 1 NC_011900.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase 530556 fba 7328195 fba Streptococcus pneumoniae ATCC 700669 fructose-bisphosphate aldolase YP_002510580.1 529675 D 561276 CDS YP_002510581.1 221231429 7328551 complement(530877..532067) 1 NC_011900.1 flavocytochrome 532067 7328551 SPN23F_05460 Streptococcus pneumoniae ATCC 700669 flavocytochrome YP_002510581.1 530877 R 561276 CDS YP_002510582.1 221231430 7328196 complement(532362..533021) 1 NC_011900.1 amino acid ABC transporter permease 533021 7328196 SPN23F_05470 Streptococcus pneumoniae ATCC 700669 amino acid ABC transporter permease YP_002510582.1 532362 R 561276 CDS YP_002510583.1 221231431 7328197 complement(533031..533708) 1 NC_011900.1 amino acid ABC transporter permease 533708 7328197 SPN23F_05480 Streptococcus pneumoniae ATCC 700669 amino acid ABC transporter permease YP_002510583.1 533031 R 561276 CDS YP_002510584.1 221231432 7328198 complement(533721..534485) 1 NC_011900.1 glutamine-binding protein precursor 534485 7328198 SPN23F_05490 Streptococcus pneumoniae ATCC 700669 glutamine-binding protein precursor YP_002510584.1 533721 R 561276 CDS YP_002510585.1 221231433 7328199 complement(534525..535283) 1 NC_011900.1 glutamine transporter, ATP-binding protein 535283 7328199 SPN23F_05500 Streptococcus pneumoniae ATCC 700669 glutamine transporter, ATP-binding protein YP_002510585.1 534525 R 561276 CDS YP_002510586.1 221231434 7328200 535560..537782 1 NC_011900.1 phosphoesterase 537782 7328200 SPN23F_05510 Streptococcus pneumoniae ATCC 700669 phosphoesterase YP_002510586.1 535560 D 561276 CDS YP_002510587.1 221231435 7328201 537957..539618 1 NC_011900.1 metallo-beta-lactamase superfamily protein 539618 7328201 SPN23F_05520 Streptococcus pneumoniae ATCC 700669 metallo-beta-lactamase superfamily protein YP_002510587.1 537957 D 561276 CDS YP_002510588.1 221231436 7328202 539687..540466 1 NC_011900.1 esterase 540466 7328202 SPN23F_05530 Streptococcus pneumoniae ATCC 700669 esterase YP_002510588.1 539687 D 561276 CDS YP_002510589.1 221231437 7328203 540578..541798 1 NC_011900.1 peptidoglycan pentaglycine interpeptide biosynthesis protein 541798 murM 7328203 murM Streptococcus pneumoniae ATCC 700669 peptidoglycan pentaglycine interpeptide biosynthesis protein YP_002510589.1 540578 D 561276 CDS YP_002510590.1 221231438 7328398 541803..543035 1 NC_011900.1 peptidoglycan branched peptide synthesis protein 543035 murN 7328398 murN Streptococcus pneumoniae ATCC 700669 peptidoglycan branched peptide synthesis protein YP_002510590.1 541803 D 561276 CDS YP_002510591.1 221231439 7328399 543114..543815 1 NC_011900.1 protease 543815 7328399 SPN23F_05560 Streptococcus pneumoniae ATCC 700669 protease YP_002510591.1 543114 D 561276 CDS YP_002510592.1 221231440 7328204 543855..545702 1 NC_011900.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 545702 uvrC 7328204 uvrC Streptococcus pneumoniae ATCC 700669 excinuclease ABC subunit C YP_002510592.1 543855 D 561276 CDS YP_002510593.1 221231441 7329425 545752..546189 1 NC_011900.1 hypothetical protein 546189 7329425 SPN23F_05580 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510593.1 545752 D 561276 CDS YP_002510594.1 221231442 7328205 546190..546525 1 NC_011900.1 hypothetical protein 546525 7328205 SPN23F_05590 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510594.1 546190 D 561276 CDS YP_002510595.1 221231443 7328206 complement(546709..547509) 1 NC_011900.1 extracellular solute-binding protein 547509 7328206 SPN23F_05600 Streptococcus pneumoniae ATCC 700669 extracellular solute-binding protein YP_002510595.1 546709 R 561276 CDS YP_002510596.1 221231444 7328207 547680..548285 1 NC_011900.1 nitroreductase family protein 548285 7328207 SPN23F_05610 Streptococcus pneumoniae ATCC 700669 nitroreductase family protein YP_002510596.1 547680 D 561276 CDS YP_002510597.1 221231445 7328208 548298..549698 1 NC_011900.1 divalent metal ion-dependent extracellular dipeptidase; able to hydrolyze a broad range of dipeptides but no tri-, tetra-, or larger oligopeptides; differences in the amino acid specificity of the cleavage site varies between species; similar to succinyl-diaminopimelate desuccinylases; dipeptidase PepV 549698 pepV 7328208 pepV Streptococcus pneumoniae ATCC 700669 dipeptidase PepV YP_002510597.1 548298 D 561276 CDS YP_002510598.1 221231446 7327831 549752..550330 1 NC_011900.1 uracil DNA glycosylase superfamily protein 550330 7327831 SPN23F_05630 Streptococcus pneumoniae ATCC 700669 uracil DNA glycosylase superfamily protein YP_002510598.1 549752 D 561276 CDS YP_002510599.1 221231447 7328209 550490..550642 1 NC_011900.1 hypothetical protein 550642 7328209 SPN23F_05640 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510599.1 550490 D 561276 CDS YP_002510600.1 221231448 7328210 550643..550777 1 NC_011900.1 hypothetical protein 550777 7328210 SPN23F_05641 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510600.1 550643 D 561276 CDS YP_002510601.1 221231449 7328211 550948..552273 1 NC_011900.1 branched-chain amino acid transport system carrier protein 552273 brnQ 7328211 brnQ Streptococcus pneumoniae ATCC 700669 branched-chain amino acid transport system carrier protein YP_002510601.1 550948 D 561276 CDS YP_002510602.1 221231450 7328698 552371..553408 1 NC_011900.1 M42 glutamyl aminopeptidase 553408 7328698 SPN23F_05660 Streptococcus pneumoniae ATCC 700669 M42 glutamyl aminopeptidase YP_002510602.1 552371 D 561276 CDS YP_002510603.1 221231451 7328212 553410..553871 1 NC_011900.1 HIT family protein 553871 7328212 SPN23F_05670 Streptococcus pneumoniae ATCC 700669 HIT family protein YP_002510603.1 553410 D 561276 CDS YP_002510604.1 221231452 7328213 553889..554605 1 NC_011900.1 carboxypeptidase 554605 7328213 SPN23F_05680 Streptococcus pneumoniae ATCC 700669 carboxypeptidase YP_002510604.1 553889 D 561276 CDS YP_002510605.1 221231453 7328214 554728..555153 1 NC_011900.1 binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 555153 rplK 7328214 rplK Streptococcus pneumoniae ATCC 700669 50S ribosomal protein L11 YP_002510605.1 554728 D 561276 CDS YP_002510606.1 221231454 7327478 555361..556050 1 NC_011900.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 556050 rplA 7327478 rplA Streptococcus pneumoniae ATCC 700669 50S ribosomal protein L1 YP_002510606.1 555361 D 561276 CDS YP_002510607.1 221231455 7328215 556946..557164 1 NC_011900.1 hypothetical protein 557164 7328215 SPN23F_05720 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510607.1 556946 D 561276 CDS YP_002510608.1 221231456 7328216 557563..557808 1 NC_011900.1 hypothetical protein 557808 7328216 SPN23F_05730 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510608.1 557563 D 561276 CDS YP_002510609.1 221231457 7328217 558209..559201 1 NC_011900.1 ABC transporter ATP-binding protein 559201 7328217 SPN23F_05740 Streptococcus pneumoniae ATCC 700669 ABC transporter ATP-binding protein YP_002510609.1 558209 D 561276 CDS YP_002510610.1 221231458 7328218 559203..560021 1 NC_011900.1 hypothetical protein 560021 7328218 SPN23F_05750 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510610.1 559203 D 561276 CDS YP_002510611.1 221231459 7328219 560023..560808 1 NC_011900.1 hypothetical protein 560808 7328219 SPN23F_05760 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510611.1 560023 D 561276 CDS YP_002510612.1 221231460 7328220 560906..561124 1 NC_011900.1 hypothetical protein 561124 7328220 SPN23F_05770 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510612.1 560906 D 561276 CDS YP_002510613.1 221231461 7328221 561109..561270 1 NC_011900.1 hypothetical protein 561270 7328221 SPN23F_05780 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510613.1 561109 D 561276 CDS YP_002510614.1 221231462 7328222 561994..568428 1 NC_011900.1 surface-anchored serine protease 568428 7328222 SPN23F_05790 Streptococcus pneumoniae ATCC 700669 surface-anchored serine protease YP_002510614.1 561994 D 561276 CDS YP_002510615.1 221231463 7328223 569060..569536 1 NC_011900.1 sugar phosphotransferase system (PTS),IIA component 569536 7328223 SPN23F_05800 Streptococcus pneumoniae ATCC 700669 sugar phosphotransferase system (PTS),IIA component YP_002510615.1 569060 D 561276 CDS YP_002510616.1 221231464 7328224 569574..569879 1 NC_011900.1 sugar phosphotransferase system (PTS), IIB component 569879 7328224 SPN23F_05810 Streptococcus pneumoniae ATCC 700669 sugar phosphotransferase system (PTS), IIB component YP_002510616.1 569574 D 561276 CDS YP_002510617.1 221231465 7328225 569927..571402 1 NC_011900.1 sugar phosphotransferase system (PTS),galactitol-specific family, IIC component 571402 7328225 SPN23F_05820 Streptococcus pneumoniae ATCC 700669 sugar phosphotransferase system (PTS),galactitol-specific family, IIC component YP_002510617.1 569927 D 561276 CDS YP_002510618.1 221231466 7328226 571752..578453 1 NC_011900.1 surface anchored beta-galactosidase 578453 bgaA 7328226 bgaA Streptococcus pneumoniae ATCC 700669 surface anchored beta-galactosidase YP_002510618.1 571752 D 561276 CDS YP_002510619.1 221231467 7328681 complement(578763..579305) 1 NC_011900.1 hypothetical protein 579305 7328681 SPN23F_05840 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510619.1 578763 R 561276 CDS YP_002510620.1 221231468 7328227 complement(579305..579550) 1 NC_011900.1 hypothetical protein 579550 7328227 SPN23F_05850 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510620.1 579305 R 561276 CDS YP_002510621.1 221231469 7328228 complement(579761..580120) 1 NC_011900.1 hypothetical protein 580120 7328228 SPN23F_05860 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510621.1 579761 R 561276 CDS YP_002510622.1 221231470 7328230 581152..581709 1 NC_011900.1 rRNA methylase 581709 7328230 SPN23F_05890 Streptococcus pneumoniae ATCC 700669 rRNA methylase YP_002510622.1 581152 D 561276 CDS YP_002510623.1 221231471 7328231 581702..581956 1 NC_011900.1 hypothetical protein 581956 7328231 SPN23F_05900 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510623.1 581702 D 561276 CDS YP_002510624.1 221231472 7328232 581968..584022 1 NC_011900.1 sodium hydrogen exchange transporter 584022 7328232 SPN23F_05910 Streptococcus pneumoniae ATCC 700669 sodium hydrogen exchange transporter YP_002510624.1 581968 D 561276 CDS YP_002510625.1 221231473 7328233 584201..585061 1 NC_011900.1 ribonuclease BN-like family protein 585061 7328233 SPN23F_05920 Streptococcus pneumoniae ATCC 700669 ribonuclease BN-like family protein YP_002510625.1 584201 D 561276 CDS YP_002510626.1 221231474 7328234 585272..585982 1 NC_011900.1 cytochrome c-type biogenesis protein CcdA 585982 ccdA 7328234 ccdA Streptococcus pneumoniae ATCC 700669 cytochrome c-type biogenesis protein CcdA YP_002510626.1 585272 D 561276 CDS YP_002510627.1 221231475 7329187 586002..586568 1 NC_011900.1 redoxin 586568 7329187 SPN23F_05940 Streptococcus pneumoniae ATCC 700669 redoxin YP_002510627.1 586002 D 561276 CDS YP_002510628.1 221231476 7328235 586579..587691 1 NC_011900.1 peptide methionine sulfoxide reductase 587691 msrAB 7328235 msrAB Streptococcus pneumoniae ATCC 700669 peptide methionine sulfoxide reductase YP_002510628.1 586579 D 561276 CDS YP_002510629.1 221231477 7328140 588049..588786 1 NC_011900.1 response regulator protein 588786 7328140 SPN23F_05960 Streptococcus pneumoniae ATCC 700669 response regulator protein YP_002510629.1 588049 D 561276 CDS YP_002510630.1 221231478 7328236 588783..590474 1 NC_011900.1 sensor histidine kinase 590474 7328236 SPN23F_05970 Streptococcus pneumoniae ATCC 700669 sensor histidine kinase YP_002510630.1 588783 D 561276 CDS YP_002510631.1 221231479 7328237 590590..591153 1 NC_011900.1 hypothetical protein 591153 7328237 SPN23F_05980 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510631.1 590590 D 561276 CDS YP_002510632.1 221231480 7328238 591175..596844 1 NC_011900.1 zinc metalloproteinase ZmpB 596844 zmpB 7328238 zmpB Streptococcus pneumoniae ATCC 700669 zinc metalloproteinase ZmpB YP_002510632.1 591175 D 561276 CDS YP_002510633.1 221231481 7329452 596905..598626 1 NC_011900.1 chorismate binding enzyme 598626 pabB 7329452 pabB Streptococcus pneumoniae ATCC 700669 chorismate binding enzyme YP_002510633.1 596905 D 561276 CDS YP_002510634.1 221231482 7328450 598746..600272 1 NC_011900.1 pneumococcal surface protein 600272 7328450 SPN23F_06010 Streptococcus pneumoniae ATCC 700669 pneumococcal surface protein YP_002510634.1 598746 D 561276 CDS YP_002510635.1 221231483 7328239 600359..601222 1 NC_011900.1 hypothetical protein 601222 7328239 SPN23F_06030 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510635.1 600359 D 561276 CDS YP_002510636.1 221231484 7328240 601413..602372 1 NC_011900.1 glucokinase 602372 glkA 7328240 glkA Streptococcus pneumoniae ATCC 700669 glucokinase YP_002510636.1 601413 D 561276 CDS YP_002510637.1 221231485 7328600 602469..603308 1 NC_011900.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase 603308 thyA 7328600 thyA Streptococcus pneumoniae ATCC 700669 thymidylate synthase YP_002510637.1 602469 D 561276 CDS YP_002510638.1 221231486 7329175 complement(603356..603526) 1 NC_011900.1 hypothetical protein 603526 7329175 SPN23F_06060 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510638.1 603356 R 561276 CDS YP_002510639.1 221231487 7328241 603647..604531 1 NC_011900.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 604531 miaA 7328241 miaA Streptococcus pneumoniae ATCC 700669 tRNA delta(2)-isopentenylpyrophosphate transferase YP_002510639.1 603647 D 561276 CDS YP_002510640.1 221231488 7328130 604524..605762 1 NC_011900.1 GTPase 605762 7328130 SPN23F_06080 Streptococcus pneumoniae ATCC 700669 GTPase YP_002510640.1 604524 D 561276 CDS YP_002510641.1 221231489 7328242 605755..606378 1 NC_011900.1 hypothetical protein 606378 7328242 SPN23F_06090 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510641.1 605755 D 561276 CDS YP_002510642.1 221231490 7328243 606393..607322 1 NC_011900.1 member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions; ribonuclease Z 607322 rnz 7328243 rnz Streptococcus pneumoniae ATCC 700669 ribonuclease Z YP_002510642.1 606393 D 561276 CDS YP_002510643.1 221231491 7327467 607343..608098 1 NC_011900.1 short chain dehydrogenase 608098 7327467 SPN23F_06110 Streptococcus pneumoniae ATCC 700669 short chain dehydrogenase YP_002510643.1 607343 D 561276 CDS YP_002510644.1 221231492 7328244 complement(608152..609120) 1 NC_011900.1 LysR family transcriptional regulator 609120 7328244 SPN23F_06120 Streptococcus pneumoniae ATCC 700669 LysR family transcriptional regulator YP_002510644.1 608152 R 561276 CDS YP_002510645.1 221231493 7328245 609124..609393 1 NC_011900.1 hypothetical protein 609393 7328245 SPN23F_06130 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510645.1 609124 D 561276 CDS YP_002510646.1 221231494 7328246 609393..609773 1 NC_011900.1 hypothetical protein 609773 7328246 SPN23F_06140 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510646.1 609393 D 561276 CDS YP_002510647.1 221231495 7328247 complement(610129..610854) 1 NC_011900.1 ribosomal small subunit pseudouridine synthase A 610854 7328247 SPN23F_06150 Streptococcus pneumoniae ATCC 700669 ribosomal small subunit pseudouridine synthase A YP_002510647.1 610129 R 561276 CDS YP_002510648.1 221231496 7328248 611016..612857 1 NC_011900.1 BipA family GTPase 612857 7328248 SPN23F_06160 Streptococcus pneumoniae ATCC 700669 BipA family GTPase YP_002510648.1 611016 D 561276 CDS YP_002510649.1 221231497 7328249 612877..613131 1 NC_011900.1 hypothetical protein 613131 7328249 SPN23F_06170 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510649.1 612877 D 561276 CDS YP_002510650.1 221231498 7328250 613679..613795 1 NC_011900.1 hypothetical protein 613795 7328250 SPN23F_06180 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510650.1 613679 D 561276 CDS YP_002510651.1 221231499 7328251 613878..614501 1 NC_011900.1 hypothetical protein 614501 7328251 SPN23F_06190 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510651.1 613878 D 561276 CDS YP_002510652.1 221231500 7328252 614724..615899 1 NC_011900.1 hypothetical protein 615899 7328252 SPN23F_06200 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510652.1 614724 D 561276 CDS YP_002510653.1 221231501 7328253 615901..616542 1 NC_011900.1 ABC transporter ATP-binding protein 616542 7328253 SPN23F_06210 Streptococcus pneumoniae ATCC 700669 ABC transporter ATP-binding protein YP_002510653.1 615901 D 561276 CDS YP_002510654.1 221231502 7328254 616646..617998 1 NC_011900.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 617998 murD 7328254 murD Streptococcus pneumoniae ATCC 700669 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase YP_002510654.1 616646 D 561276 CDS YP_002510655.1 221231503 7328394 618002..619060 1 NC_011900.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; UDP diphospho-muramoyl pentapeptide beta-N acetylglucosaminyl transferase 619060 murG 7328394 murG Streptococcus pneumoniae ATCC 700669 UDP diphospho-muramoyl pentapeptide beta-N acetylglucosaminyl transferase YP_002510655.1 618002 D 561276 CDS YP_002510656.1 221231504 7328397 619070..620269 1 NC_011900.1 cell division protein DivIB/FtsQ 620269 divIB 7328397 divIB Streptococcus pneumoniae ATCC 700669 cell division protein DivIB/FtsQ YP_002510656.1 619070 D 561276 CDS YP_002510657.1 221231505 7329232 620502..621203 1 NC_011900.1 type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 621203 pyrF 7329232 pyrF Streptococcus pneumoniae ATCC 700669 orotidine 5'-phosphate decarboxylase YP_002510657.1 620502 D 561276 CDS YP_002510658.1 221231506 7327433 621237..621869 1 NC_011900.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 621869 pyrE 7327433 pyrE Streptococcus pneumoniae ATCC 700669 orotate phosphoribosyltransferase YP_002510658.1 621237 D 561276 CDS YP_002510659.1 221231507 7327432 622102..622452 1 NC_011900.1 hypothetical protein 622452 7327432 SPN23F_06270 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510659.1 622102 D 561276 CDS YP_002510660.1 221231508 7328255 622548..623312 1 NC_011900.1 hypothetical protein 623312 7328255 SPN23F_06280 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510660.1 622548 D 561276 CDS YP_002510661.1 221231509 7328256 623312..624064 1 NC_011900.1 hypothetical protein 624064 7328256 SPN23F_06290 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510661.1 623312 D 561276 CDS YP_002510662.1 221231510 7328257 624068..624772 1 NC_011900.1 hypothetical protein 624772 7328257 SPN23F_06300 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510662.1 624068 D 561276 CDS YP_002510663.1 221231511 7328258 624769..625416 1 NC_011900.1 heme exporter protein A (cytochrome C-type biogenesis protein) 625416 ccmA 7328258 ccmA Streptococcus pneumoniae ATCC 700669 heme exporter protein A (cytochrome C-type biogenesis protein) YP_002510663.1 624769 D 561276 CDS YP_002510664.1 221231512 7328260 complement(626369..627127) 1 NC_011900.1 amino acid ABC transporter ATP-binding protein 627127 7328260 SPN23F_06340 Streptococcus pneumoniae ATCC 700669 amino acid ABC transporter ATP-binding protein YP_002510664.1 626369 R 561276 CDS YP_002510665.1 221231513 7328261 complement(627128..627805) 1 NC_011900.1 amino acid ABC transporter permease 627805 7328261 SPN23F_06350 Streptococcus pneumoniae ATCC 700669 amino acid ABC transporter permease YP_002510665.1 627128 R 561276 CDS YP_002510666.1 221231514 7328262 complement(627765..628385) 1 NC_011900.1 amino acid ABC transporter permease 628385 7328262 SPN23F_06360 Streptococcus pneumoniae ATCC 700669 amino acid ABC transporter permease YP_002510666.1 627765 R 561276 CDS YP_002510667.1 221231515 7328263 628659..628805 1 NC_011900.1 L-lactate oxidase-related protein 628805 7328263 SPN23F_06370 Streptococcus pneumoniae ATCC 700669 L-lactate oxidase-related protein YP_002510667.1 628659 D 561276 CDS YP_002510668.1 221231516 7328264 628933..630423 1 NC_011900.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 630423 lysS 7328264 lysS Streptococcus pneumoniae ATCC 700669 lysyl-tRNA synthetase YP_002510668.1 628933 D 561276 CDS YP_002510669.1 221231517 7328113 631049..632185 1 NC_011900.1 L-lactate oxidase 632185 lctO 7328113 lctO Streptococcus pneumoniae ATCC 700669 L-lactate oxidase YP_002510669.1 631049 D 561276 CDS YP_002510670.1 221231518 7329466 632742..633410 1 NC_011900.1 coenzyme 633410 7329466 SPN23F_06400 Streptococcus pneumoniae ATCC 700669 coenzyme YP_002510670.1 632742 D 561276 CDS YP_002510671.1 221231519 7328265 633736..634518 1 NC_011900.1 catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP; hydroxyethylthiazole kinase 634518 thiM 7328265 thiM Streptococcus pneumoniae ATCC 700669 hydroxyethylthiazole kinase YP_002510671.1 633736 D 561276 CDS YP_002510672.1 221231520 7329171 634520..635149 1 NC_011900.1 thiamine-phosphate pyrophosphorylase 635149 thiE 7329171 thiE Streptococcus pneumoniae ATCC 700669 thiamine-phosphate pyrophosphorylase YP_002510672.1 634520 D 561276 CDS YP_002510673.1 221231521 7329467 635708..636268 1 NC_011900.1 hypothetical protein 636268 7329467 SPN23F_06440 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510673.1 635708 D 561276 CDS YP_002510674.1 221231522 7328266 636269..637654 1 NC_011900.1 ABC transporter ATP-binding protein 637654 7328266 SPN23F_06450 Streptococcus pneumoniae ATCC 700669 ABC transporter ATP-binding protein YP_002510674.1 636269 D 561276 CDS YP_002510675.1 221231523 7328267 637656..638306 1 NC_011900.1 hypothetical protein 638306 7328267 SPN23F_06460 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510675.1 637656 D 561276 CDS YP_002510676.1 221231524 7328268 638317..639009 1 NC_011900.1 coenzyme 639009 7328268 SPN23F_06470 Streptococcus pneumoniae ATCC 700669 coenzyme YP_002510676.1 638317 D 561276 CDS YP_002510677.1 221231525 7328269 639014..639538 1 NC_011900.1 hypothetical protein 639538 7328269 SPN23F_06480 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510677.1 639014 D 561276 CDS YP_002510678.1 221231526 7328270 639538..640341 1 NC_011900.1 hydroxyethylthiazole kinase 640341 7328270 SPN23F_06490 Streptococcus pneumoniae ATCC 700669 hydroxyethylthiazole kinase YP_002510678.1 639538 D 561276 CDS YP_002510679.1 221231527 7328271 640334..640966 1 NC_011900.1 Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate; thiamine-phosphate pyrophosphorylase 640966 thiE 7328271 thiE Streptococcus pneumoniae ATCC 700669 thiamine-phosphate pyrophosphorylase YP_002510679.1 640334 D 561276 CDS YP_002510680.1 221231528 7329169 complement(641176..641967) 1 NC_011900.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase 641967 thiD 7329169 thiD Streptococcus pneumoniae ATCC 700669 phosphomethylpyrimidine kinase YP_002510680.1 641176 R 561276 CDS YP_002510681.1 221231529 7329468 642333..642728 1 NC_011900.1 Homologues control the copper transport or penicillin resistance; regulator 642728 7329468 SPN23F_06520 Streptococcus pneumoniae ATCC 700669 regulator YP_002510681.1 642333 D 561276 CDS YP_002510682.1 221231530 7328272 642739..643110 1 NC_011900.1 hypothetical protein 643110 7328272 SPN23F_06530 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510682.1 642739 D 561276 CDS YP_002510683.1 221231531 7328273 643120..645363 1 NC_011900.1 metal transporting P-type ATPase 645363 7328273 SPN23F_06540 Streptococcus pneumoniae ATCC 700669 metal transporting P-type ATPase YP_002510683.1 643120 D 561276 CDS YP_002510684.1 221231532 7328274 645570..647345 1 NC_011900.1 pyruvate oxidase 647345 spxB 7328274 spxB Streptococcus pneumoniae ATCC 700669 pyruvate oxidase YP_002510684.1 645570 D 561276 CDS YP_002510685.1 221231533 7329152 647456..647803 1 NC_011900.1 glyoxalase family protein 647803 7329152 SPN23F_06560 Streptococcus pneumoniae ATCC 700669 glyoxalase family protein YP_002510685.1 647456 D 561276 CDS YP_002510686.1 221231534 7328277 649241..649522 1 NC_011900.1 glycosyl hydrolase 649522 7328277 SPN23F_06590 Streptococcus pneumoniae ATCC 700669 glycosyl hydrolase YP_002510686.1 649241 D 561276 CDS YP_002510687.1 221231535 7328278 649654..650598 1 NC_011900.1 mannose-6-phosphate isomerase 650598 pmi 7328278 pmi Streptococcus pneumoniae ATCC 700669 mannose-6-phosphate isomerase YP_002510687.1 649654 D 561276 CDS YP_002510688.1 221231536 7328279 652270..652932 1 NC_011900.1 MerR-family transcriptional regulator 652932 7328279 SPN23F_06630 Streptococcus pneumoniae ATCC 700669 MerR-family transcriptional regulator YP_002510688.1 652270 D 561276 CDS YP_002510689.1 221231537 7328280 complement(652961..653377) 1 NC_011900.1 MutT/NUDIX family protein 653377 7328280 SPN23F_06640 Streptococcus pneumoniae ATCC 700669 MutT/NUDIX family protein YP_002510689.1 652961 R 561276 CDS YP_002510690.1 221231538 7328281 complement(653436..654611) 1 NC_011900.1 hypothetical protein 654611 7328281 SPN23F_06650 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510690.1 653436 R 561276 CDS YP_002510691.1 221231539 7328282 complement(654670..655515) 1 NC_011900.1 fatty-acid binding protein 655515 7328282 SPN23F_06660 Streptococcus pneumoniae ATCC 700669 fatty-acid binding protein YP_002510691.1 654670 R 561276 CDS YP_002510692.1 221231540 7328283 655640..656197 1 NC_011900.1 TetR family transcriptional regulator 656197 7328283 SPN23F_06670 Streptococcus pneumoniae ATCC 700669 TetR family transcriptional regulator YP_002510692.1 655640 D 561276 CDS YP_002510693.1 221231541 7328284 656216..656683 1 NC_011900.1 cytidine and deoxycytidylate deaminase 656683 7328284 SPN23F_06680 Streptococcus pneumoniae ATCC 700669 cytidine and deoxycytidylate deaminase YP_002510693.1 656216 D 561276 CDS YP_002510694.1 221231542 7328285 656751..657401 1 NC_011900.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 657401 upp 7328285 upp Streptococcus pneumoniae ATCC 700669 uracil phosphoribosyltransferase YP_002510694.1 656751 D 561276 CDS YP_002510695.1 221231543 7329421 657575..658165 1 NC_011900.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 658165 clpP 7329421 clpP Streptococcus pneumoniae ATCC 700669 ATP-dependent Clp protease proteolytic subunit YP_002510695.1 657575 D 561276 CDS YP_002510696.1 221231544 7329198 658244..658492 1 NC_011900.1 hypothetical protein 658492 7329198 SPN23F_06710 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510696.1 658244 D 561276 CDS YP_002510697.1 221231545 7328286 658594..659754 1 NC_011900.1 branched-chain amino acid ABC transporter, amino acid-binding protein 659754 7328286 SPN23F_06720 Streptococcus pneumoniae ATCC 700669 branched-chain amino acid ABC transporter, amino acid-binding protein YP_002510697.1 658594 D 561276 CDS YP_002510698.1 221231546 7328287 660022..660891 1 NC_011900.1 branched-chain amino acid transport system permease protein 660891 7328287 SPN23F_06730 Streptococcus pneumoniae ATCC 700669 branched-chain amino acid transport system permease protein YP_002510698.1 660022 D 561276 CDS YP_002510699.1 221231547 7328288 660895..661851 1 NC_011900.1 branched-chain amino acid transport system permease protein 661851 7328288 SPN23F_06740 Streptococcus pneumoniae ATCC 700669 branched-chain amino acid transport system permease protein YP_002510699.1 660895 D 561276 CDS YP_002510700.1 221231548 7328289 661851..662615 1 NC_011900.1 branched-chain amino acid transport ATP-binding protein 662615 7328289 SPN23F_06750 Streptococcus pneumoniae ATCC 700669 branched-chain amino acid transport ATP-binding protein YP_002510700.1 661851 D 561276 CDS YP_002510701.1 221231549 7328290 662615..663325 1 NC_011900.1 branched-chain amino acid transport ATP-binding protein 663325 7328290 SPN23F_06760 Streptococcus pneumoniae ATCC 700669 branched-chain amino acid transport ATP-binding protein YP_002510701.1 662615 D 561276 CDS YP_002510702.1 221231550 7328291 663633..664289 1 NC_011900.1 hypothetical protein 664289 7328291 SPN23F_06770 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510702.1 663633 D 561276 CDS YP_002510703.1 221231551 7328292 664515..665492 1 NC_011900.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 665492 prfB 7328292 prfB Streptococcus pneumoniae ATCC 700669 peptide chain release factor 2 YP_002510703.1 664515 D 561276 CDS YP_002510704.1 221231552 7327873 665510..666202 1 NC_011900.1 cell division ATP-binding protein 666202 ftsE 7327873 ftsE Streptococcus pneumoniae ATCC 700669 cell division ATP-binding protein YP_002510704.1 665510 D 561276 CDS YP_002510705.1 221231553 7328568 666195..667121 1 NC_011900.1 cell division protein 667121 ftsX 7328568 ftsX Streptococcus pneumoniae ATCC 700669 cell division protein YP_002510705.1 666195 D 561276 CDS YP_002510706.1 221231554 7328572 667407..669587 1 NC_011900.1 glucose-specific phosphotransferase system (PTS), IIABC component 669587 7328572 SPN23F_06810 Streptococcus pneumoniae ATCC 700669 glucose-specific phosphotransferase system (PTS), IIABC component YP_002510706.1 667407 D 561276 CDS YP_002510707.1 221231555 7328293 669639..670454 1 NC_011900.1 endonuclease/exonuclease/phosphatase family protein 670454 7328293 SPN23F_06820 Streptococcus pneumoniae ATCC 700669 endonuclease/exonuclease/phosphatase family protein YP_002510707.1 669639 D 561276 CDS YP_002510708.1 221231556 7328294 670594..671937 1 NC_011900.1 helicase 671937 7328294 SPN23F_06830 Streptococcus pneumoniae ATCC 700669 helicase YP_002510708.1 670594 D 561276 CDS YP_002510709.1 221231557 7328295 672152..673342 1 NC_011900.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 673342 metK 7328295 metK Streptococcus pneumoniae ATCC 700669 S-adenosylmethionine synthetase YP_002510709.1 672152 D 561276 CDS YP_002510710.1 221231558 7328129 673895..674830 1 NC_011900.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; subclass 1A is a dimer formed by two identical PyrD subunits each containing an FMN group; dihydroorotate dehydrogenase 1A 674830 pyrD 7328129 pyrD Streptococcus pneumoniae ATCC 700669 dihydroorotate dehydrogenase 1A YP_002510710.1 673895 D 561276 CDS YP_002510711.1 221231559 7327430 674864..675901 1 NC_011900.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta 675901 holA 7327430 holA Streptococcus pneumoniae ATCC 700669 DNA polymerase III subunit delta YP_002510711.1 674864 D 561276 CDS YP_002510712.1 221231560 7328296 676042..676647 1 NC_011900.1 superoxide dismutase 676647 sodA 7328296 sodA Streptococcus pneumoniae ATCC 700669 superoxide dismutase YP_002510712.1 676042 D 561276 CDS YP_002510713.1 221231561 7329147 676805..677335 1 NC_011900.1 hypothetical protein 677335 7329147 SPN23F_06890 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510713.1 676805 D 561276 CDS YP_002510714.1 221231562 7328297 677356..678258 1 NC_011900.1 Appears to have undergone an in-frame deletion relative to other pneumococcal orthologues; radical SAM superfamily protein 678258 7328297 SPN23F_06900 Streptococcus pneumoniae ATCC 700669 radical SAM superfamily protein YP_002510714.1 677356 D 561276 CDS YP_002510715.1 221231563 7328298 678258..678740 1 NC_011900.1 VanZ like family protein 678740 7328298 SPN23F_06910 Streptococcus pneumoniae ATCC 700669 VanZ like family protein YP_002510715.1 678258 D 561276 CDS YP_002510716.1 221231564 7328299 678742..680283 1 NC_011900.1 ABC transporter ATP-binding protein 680283 7328299 SPN23F_06920 Streptococcus pneumoniae ATCC 700669 ABC transporter ATP-binding protein YP_002510716.1 678742 D 561276 CDS YP_002510717.1 221231565 7328300 complement(680338..681594) 1 NC_011900.1 IS1167A transposase 681594 7328300 SPN23F_06930 Streptococcus pneumoniae ATCC 700669 IS1167A transposase YP_002510717.1 680338 R 561276 CDS YP_002510718.1 221231566 7328059 complement(681761..682564) 1 NC_011900.1 cyclophilin type peptidyl-prolyl cis-trans isomerase 682564 7328059 SPN23F_06940 Streptococcus pneumoniae ATCC 700669 cyclophilin type peptidyl-prolyl cis-trans isomerase YP_002510718.1 681761 R 561276 CDS YP_002510719.1 221231567 7327740 complement(682648..682869) 1 NC_011900.1 hypothetical protein 682869 7327740 SPN23F_06950 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510719.1 682648 R 561276 CDS YP_002510720.1 221231568 7327741 683727..683999 1 NC_011900.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 683999 rpsP 7327741 rpsP Streptococcus pneumoniae ATCC 700669 30S ribosomal protein S16 YP_002510720.1 683727 D 561276 CDS YP_002510721.1 221231569 7329122 684019..684258 1 NC_011900.1 hypothetical protein 684258 7329122 SPN23F_06970 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510721.1 684019 D 561276 CDS YP_002510722.1 221231570 7327742 684834..685583 1 NC_011900.1 hypothetical protein 685583 7327742 SPN23F_06980 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510722.1 684834 D 561276 CDS YP_002510723.1 221231571 7327743 685653..686171 1 NC_011900.1 Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 686171 rimM 7327743 rimM Streptococcus pneumoniae ATCC 700669 16S rRNA-processing protein RimM YP_002510723.1 685653 D 561276 CDS YP_002510724.1 221231572 7327457 686161..686880 1 NC_011900.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 686880 trmD 7327457 trmD Streptococcus pneumoniae ATCC 700669 tRNA (guanine-N(1)-)-methyltransferase YP_002510724.1 686161 D 561276 CDS YP_002510725.1 221231573 7327585 686892..687230 1 NC_011900.1 ATP-binding protein 687230 7327585 SPN23F_07010 Streptococcus pneumoniae ATCC 700669 ATP-binding protein YP_002510725.1 686892 D 561276 CDS YP_002510726.1 221231574 7327744 complement(687261..687581) 1 NC_011900.1 hypothetical protein 687581 7327744 SPN23F_07020 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510726.1 687261 R 561276 CDS YP_002510727.1 221231575 7327745 687655..687894 1 NC_011900.1 hypothetical protein 687894 7327745 SPN23F_07030 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510727.1 687655 D 561276 CDS YP_002510728.1 221231576 7327746 complement(687891..688037) 1 NC_011900.1 hypothetical protein 688037 7327746 SPN23F_07040 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510728.1 687891 R 561276 CDS YP_002510729.1 221231577 7327747 complement(688099..688635) 1 NC_011900.1 BioY family membrane protein 688635 7327747 SPN23F_07050 Streptococcus pneumoniae ATCC 700669 BioY family membrane protein YP_002510729.1 688099 R 561276 CDS YP_002510730.1 221231578 7327748 689061..689399 1 NC_011900.1 hypothetical protein 689399 7327748 SPN23F_07060 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510730.1 689061 D 561276 CDS YP_002510731.1 221231579 7327749 689465..691447 1 NC_011900.1 ATP/GTP-binding transport protein 691447 7327749 SPN23F_07070 Streptococcus pneumoniae ATCC 700669 ATP/GTP-binding transport protein YP_002510731.1 689465 D 561276 CDS YP_002510732.1 221231580 7327750 691444..692067 1 NC_011900.1 ABC transporter ATP-binding protein 692067 7327750 SPN23F_07080 Streptococcus pneumoniae ATCC 700669 ABC transporter ATP-binding protein YP_002510732.1 691444 D 561276 CDS YP_002510733.1 221231581 7327751 692064..692564 1 NC_011900.1 hypothetical protein 692564 7327751 SPN23F_07090 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510733.1 692064 D 561276 CDS YP_002510734.1 221231582 7327752 complement(692730..694076) 1 NC_011900.1 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase 694076 gor 7327752 gor Streptococcus pneumoniae ATCC 700669 glutathione reductase YP_002510734.1 692730 R 561276 CDS YP_002510735.1 221231583 7328618 694341..695540 1 NC_011900.1 hypothetical protein 695540 7328618 SPN23F_07110 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510735.1 694341 D 561276 CDS YP_002510736.1 221231584 7327753 695524..696225 1 NC_011900.1 ABC transporter ATP-binding protein 696225 7327753 SPN23F_07120 Streptococcus pneumoniae ATCC 700669 ABC transporter ATP-binding protein YP_002510736.1 695524 D 561276 CDS YP_002510737.1 221231585 7327754 696227..697486 1 NC_011900.1 permease 697486 7327754 SPN23F_07130 Streptococcus pneumoniae ATCC 700669 permease YP_002510737.1 696227 D 561276 CDS YP_002510738.1 221231586 7327755 697610..699607 1 NC_011900.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 699607 metG 7327755 metG Streptococcus pneumoniae ATCC 700669 methionyl-tRNA synthetase YP_002510738.1 697610 D 561276 CDS YP_002510739.1 221231587 7328128 699938..700258 1 NC_011900.1 PadR family transcriptional regulator 700258 7328128 SPN23F_07160 Streptococcus pneumoniae ATCC 700669 PadR family transcriptional regulator YP_002510739.1 699938 D 561276 CDS YP_002510740.1 221231588 7327756 700262..701077 1 NC_011900.1 hypothetical protein 701077 7327756 SPN23F_07170 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510740.1 700262 D 561276 CDS YP_002510741.1 221231589 7327757 701152..702078 1 NC_011900.1 oxidoreductase 702078 7327757 SPN23F_07180 Streptococcus pneumoniae ATCC 700669 oxidoreductase YP_002510741.1 701152 D 561276 CDS YP_002510742.1 221231590 7327758 702174..702410 1 NC_011900.1 hypothetical protein 702410 7327758 SPN23F_07190 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510742.1 702174 D 561276 CDS YP_002510743.1 221231591 7327759 702403..703101 1 NC_011900.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 703101 fabG 7327759 fabG Streptococcus pneumoniae ATCC 700669 3-ketoacyl-ACP reductase YP_002510743.1 702403 D 561276 CDS YP_002510744.1 221231592 7327760 703112..703591 1 NC_011900.1 NUDIX family protein 703591 7327760 SPN23F_07210 Streptococcus pneumoniae ATCC 700669 NUDIX family protein YP_002510744.1 703112 D 561276 CDS YP_002510745.1 221231593 7327761 703599..704327 1 NC_011900.1 GNAT family acetyltransferase 704327 7327761 SPN23F_07220 Streptococcus pneumoniae ATCC 700669 GNAT family acetyltransferase YP_002510745.1 703599 D 561276 CDS YP_002510746.1 221231594 7327762 704369..705238 1 NC_011900.1 PEP-utilizing enzyme 705238 7327762 SPN23F_07230 Streptococcus pneumoniae ATCC 700669 PEP-utilizing enzyme YP_002510746.1 704369 D 561276 CDS YP_002510747.1 221231595 7327763 705213..705653 1 NC_011900.1 hypothetical protein 705653 7327763 SPN23F_07240 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510747.1 705213 D 561276 CDS YP_002510748.1 221231596 7327764 705776..708322 1 NC_011900.1 lysyl-aminopeptidase 708322 pepN 7327764 pepN Streptococcus pneumoniae ATCC 700669 lysyl-aminopeptidase YP_002510748.1 705776 D 561276 CDS YP_002510749.1 221231597 7327826 complement(708380..709636) 1 NC_011900.1 IS1167A transposase 709636 7327826 SPN23F_07260 Streptococcus pneumoniae ATCC 700669 IS1167A transposase YP_002510749.1 708380 R 561276 CDS YP_002510750.1 221231598 7327765 709854..710528 1 NC_011900.1 response regulator protein 710528 ciaR 7327765 ciaR Streptococcus pneumoniae ATCC 700669 response regulator protein YP_002510750.1 709854 D 561276 CDS YP_002510751.1 221231599 7329193 710518..711852 1 NC_011900.1 sensor histidine kinase 711852 ciaH 7329193 ciaH Streptococcus pneumoniae ATCC 700669 sensor histidine kinase YP_002510751.1 710518 D 561276 CDS YP_002510752.1 221231600 7329192 complement(711886..712173) 1 NC_011900.1 hypothetical protein 712173 7329192 SPN23F_07290 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510752.1 711886 R 561276 CDS YP_002510753.1 221231601 7327766 712313..713242 1 NC_011900.1 peptidase 713242 7327766 SPN23F_07300 Streptococcus pneumoniae ATCC 700669 peptidase YP_002510753.1 712313 D 561276 CDS YP_002510754.1 221231602 7327767 713442..715892 1 NC_011900.1 unwinds DNA; bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon 715892 7327767 SPN23F_07310 Streptococcus pneumoniae ATCC 700669 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon YP_002510754.1 713442 D 561276 CDS YP_002510755.1 221231603 7327768 715929..717152 1 NC_011900.1 peptidoglycan biosynthesis membrane protein 717152 7327768 SPN23F_07320 Streptococcus pneumoniae ATCC 700669 peptidoglycan biosynthesis membrane protein YP_002510755.1 715929 D 561276 CDS YP_002510756.1 221231604 7327769 717163..717717 1 NC_011900.1 DJ-1/PfpI family protein 717717 7327769 SPN23F_07330 Streptococcus pneumoniae ATCC 700669 DJ-1/PfpI family protein YP_002510756.1 717163 D 561276 CDS YP_002510757.1 221231605 7327770 717802..718365 1 NC_011900.1 haloacid dehalogenase-like hydrolase 718365 7327770 SPN23F_07340 Streptococcus pneumoniae ATCC 700669 haloacid dehalogenase-like hydrolase YP_002510757.1 717802 D 561276 CDS YP_002510758.1 221231606 7327771 718380..720326 1 NC_011900.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 720326 gyrB 7327771 gyrB Streptococcus pneumoniae ATCC 700669 DNA gyrase subunit B YP_002510758.1 718380 D 561276 CDS YP_002510759.1 221231607 7328066 720408..722135 1 NC_011900.1 acts to negatively regulates ftsZ ring formation by modulating the frequency and position of the ftsZ ring formation; septation ring formation regulator EzrA 722135 ezrA 7328066 ezrA Streptococcus pneumoniae ATCC 700669 septation ring formation regulator EzrA YP_002510759.1 720408 D 561276 CDS YP_002510760.1 221231608 7327772 complement(723448..723747) 1 NC_011900.1 hypothetical protein 723747 7327772 SPN23F_07380 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510760.1 723448 R 561276 CDS YP_002510761.1 221231609 7327773 complement(723912..724334) 1 NC_011900.1 MutT/NUDIX hydrolase family protein 724334 7327773 SPN23F_07390 Streptococcus pneumoniae ATCC 700669 MutT/NUDIX hydrolase family protein YP_002510761.1 723912 R 561276 CDS YP_002510762.1 221231610 7327775 complement(725499..727757) 1 NC_011900.1 ATP-dependent Clp protease ATP-binding subunit 727757 clpE 7327775 clpE Streptococcus pneumoniae ATCC 700669 ATP-dependent Clp protease ATP-binding subunit YP_002510762.1 725499 R 561276 CDS YP_002510763.1 221231611 7329196 complement(727986..728216) 1 NC_011900.1 hypothetical protein 728216 7329196 SPN23F_07430 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510763.1 727986 R 561276 CDS YP_002510764.1 221231612 7327776 728406..729089 1 NC_011900.1 amino acid ABC transporter permease 729089 7327776 SPN23F_07440 Streptococcus pneumoniae ATCC 700669 amino acid ABC transporter permease YP_002510764.1 728406 D 561276 CDS YP_002510765.1 221231613 7327777 729089..729823 1 NC_011900.1 glutamine transporter, ATP-binding protein 3 729823 glnQ3 7327777 glnQ3 Streptococcus pneumoniae ATCC 700669 glutamine transporter, ATP-binding protein 3 YP_002510765.1 729089 D 561276 CDS YP_002510766.1 221231614 7328605 729956..730834 1 NC_011900.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 730834 folD 7328605 folD Streptococcus pneumoniae ATCC 700669 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase YP_002510766.1 729956 D 561276 CDS YP_002510767.1 221231615 7328559 730971..731792 1 NC_011900.1 hypothetical protein 731792 7328559 SPN23F_07470 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510767.1 730971 D 561276 CDS YP_002510768.1 221231616 7327778 731806..732645 1 NC_011900.1 carbohydrate kinase 732645 7327778 SPN23F_07480 Streptococcus pneumoniae ATCC 700669 carbohydrate kinase YP_002510768.1 731806 D 561276 CDS YP_002510769.1 221231617 7327779 732943..733626 1 NC_011900.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A 733626 rpiA 7327779 rpiA Streptococcus pneumoniae ATCC 700669 ribose-5-phosphate isomerase A YP_002510769.1 732943 D 561276 CDS YP_002510770.1 221231618 7327469 733640..734851 1 NC_011900.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose; phosphopentomutase 734851 deoB 7327469 deoB Streptococcus pneumoniae ATCC 700669 phosphopentomutase YP_002510770.1 733640 D 561276 CDS YP_002510771.1 221231619 7329226 734853..735395 1 NC_011900.1 hypothetical protein 735395 7329226 SPN23F_07510 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510771.1 734853 D 561276 CDS YP_002510772.1 221231620 7327780 735411..736220 1 NC_011900.1 catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation; purine nucleoside phosphorylase 736220 punA 7327780 punA Streptococcus pneumoniae ATCC 700669 purine nucleoside phosphorylase YP_002510772.1 735411 D 561276 CDS YP_002510773.1 221231621 7327782 738866..739576 1 NC_011900.1 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase 739576 deoD 7327782 deoD Streptococcus pneumoniae ATCC 700669 purine nucleoside phosphorylase YP_002510773.1 738866 D 561276 CDS YP_002510774.1 221231622 7329228 complement(739599..740123) 1 NC_011900.1 topology modulation protein 740123 7329228 SPN23F_07580 Streptococcus pneumoniae ATCC 700669 topology modulation protein YP_002510774.1 739599 R 561276 CDS YP_002510775.1 221231623 7327783 complement(740176..740412) 1 NC_011900.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 740412 rpsT 7327783 rpsT Streptococcus pneumoniae ATCC 700669 30S ribosomal protein S20 YP_002510775.1 740176 R 561276 CDS YP_002510776.1 221231624 7329126 complement(740480..741400) 1 NC_011900.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase 741400 coaA 7329126 coaA Streptococcus pneumoniae ATCC 700669 pantothenate kinase YP_002510776.1 740480 R 561276 CDS YP_002510777.1 221231625 7327784 742209..742790 1 NC_011900.1 methyltransferase 742790 7327784 SPN23F_07620 Streptococcus pneumoniae ATCC 700669 methyltransferase YP_002510777.1 742209 D 561276 CDS YP_002510778.1 221231626 7327785 742787..744064 1 NC_011900.1 Catalyzes the reversible phosphorolysis of pyrimidines in the nucleotide synthesis salvage pathway; pyrimidine-nucleoside phosphorylase 744064 deoA 7327785 deoA Streptococcus pneumoniae ATCC 700669 pyrimidine-nucleoside phosphorylase YP_002510778.1 742787 D 561276 CDS YP_002510779.1 221231627 7329225 744082..744744 1 NC_011900.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 744744 deoC 7329225 deoC Streptococcus pneumoniae ATCC 700669 deoxyribose-phosphate aldolase YP_002510779.1 744082 D 561276 CDS YP_002510780.1 221231628 7329227 744731..745120 1 NC_011900.1 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 745120 cdd 7329227 cdd Streptococcus pneumoniae ATCC 700669 cytidine deaminase YP_002510780.1 744731 D 561276 CDS YP_002510781.1 221231629 7329191 745211..746263 1 NC_011900.1 lipoprotein 746263 7329191 SPN23F_07660 Streptococcus pneumoniae ATCC 700669 lipoprotein YP_002510781.1 745211 D 561276 CDS YP_002510782.1 221231630 7327786 746407..747942 1 NC_011900.1 ABC transporter ATP-binding protein 747942 7327786 SPN23F_07670 Streptococcus pneumoniae ATCC 700669 ABC transporter ATP-binding protein YP_002510782.1 746407 D 561276 CDS YP_002510783.1 221231631 7327787 747935..748993 1 NC_011900.1 ABC transporter permease 748993 7327787 SPN23F_07680 Streptococcus pneumoniae ATCC 700669 ABC transporter permease YP_002510783.1 747935 D 561276 CDS YP_002510784.1 221231632 7327788 748996..749952 1 NC_011900.1 ABC transporter permease 749952 7327788 SPN23F_07690 Streptococcus pneumoniae ATCC 700669 ABC transporter permease YP_002510784.1 748996 D 561276 CDS YP_002510785.1 221231633 7327790 750553..751386 1 NC_011900.1 IS3-Spn1 orf B 751386 7327790 SPN23F_07720 Streptococcus pneumoniae ATCC 700669 IS3-Spn1 orf B YP_002510785.1 750553 D 561276 CDS YP_002510786.1 221231634 7327791 complement(751429..752070) 1 NC_011900.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX; glycerol-3-phosphate acyltransferase PlsY 752070 7327791 SPN23F_07730 Streptococcus pneumoniae ATCC 700669 glycerol-3-phosphate acyltransferase PlsY YP_002510786.1 751429 R 561276 CDS YP_002510787.1 221231635 7327792 752206..754149 1 NC_011900.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B 754149 parE 7327792 parE Streptococcus pneumoniae ATCC 700669 DNA topoisomerase IV subunit B YP_002510787.1 752206 D 561276 CDS YP_002510788.1 221231636 7328452 754605..757040 1 NC_011900.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A 757040 parC 7328452 parC Streptococcus pneumoniae ATCC 700669 DNA topoisomerase IV subunit A YP_002510788.1 754605 D 561276 CDS YP_002510789.1 221231637 7328451 757172..758194 1 NC_011900.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 758194 7328451 SPN23F_07770 Streptococcus pneumoniae ATCC 700669 branched-chain amino acid aminotransferase YP_002510789.1 757172 D 561276 CDS YP_002510790.1 221231638 7327793 758250..758954 1 NC_011900.1 extracellular oligopeptide-binding protein 758954 7327793 SPN23F_07780 Streptococcus pneumoniae ATCC 700669 extracellular oligopeptide-binding protein YP_002510790.1 758250 D 561276 CDS YP_002510791.1 221231639 7327794 759019..759708 1 NC_011900.1 hypothetical protein 759708 7327794 SPN23F_07790 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510791.1 759019 D 561276 CDS YP_002510792.1 221231640 7327795 759705..760628 1 NC_011900.1 hypothetical protein 760628 7327795 SPN23F_07800 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510792.1 759705 D 561276 CDS YP_002510793.1 221231641 7327796 760643..761287 1 NC_011900.1 catalyzes the removal of 5-oxoproline from various penultimate amino acid residues except L-proline; pyrrolidone-carboxylate peptidase 761287 pcp 7327796 pcp Streptococcus pneumoniae ATCC 700669 pyrrolidone-carboxylate peptidase YP_002510793.1 760643 D 561276 CDS YP_002510794.1 221231642 7328459 761455..761685 1 NC_011900.1 hypothetical protein 761685 7328459 SPN23F_07820 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510794.1 761455 D 561276 CDS YP_002510795.1 221231643 7327601 762058..763260 1 NC_011900.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 763260 rpsA 7327601 rpsA Streptococcus pneumoniae ATCC 700669 30S ribosomal protein S1 YP_002510795.1 762058 D 561276 CDS YP_002510796.1 221231644 7327800 764840..765337 1 NC_011900.1 hypothetical protein 765337 7327800 SPN23F_07870 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510796.1 764840 D 561276 CDS YP_002510797.1 221231645 7327801 765337..766992 1 NC_011900.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma/tau 766992 dnaH 7327801 dnaH Streptococcus pneumoniae ATCC 700669 DNA polymerase III subunits gamma/tau YP_002510797.1 765337 D 561276 CDS YP_002510798.1 221231646 7329242 767364..768134 1 NC_011900.1 FeS assembly ATPase SufC, ABC transporter ATP-binding protein 768134 sufC 7329242 sufC Streptococcus pneumoniae ATCC 700669 FeS assembly ATPase SufC, ABC transporter ATP-binding protein YP_002510798.1 767364 D 561276 CDS YP_002510799.1 221231647 7329160 768162..769424 1 NC_011900.1 FeS assembly protein SufD 769424 sufD 7329160 sufD Streptococcus pneumoniae ATCC 700669 FeS assembly protein SufD YP_002510799.1 768162 D 561276 CDS YP_002510800.1 221231648 7329161 769435..770661 1 NC_011900.1 cysteine desulfurase 770661 csdB 7329161 csdB Streptococcus pneumoniae ATCC 700669 cysteine desulfurase YP_002510800.1 769435 D 561276 CDS YP_002510801.1 221231649 7329214 770648..771088 1 NC_011900.1 FeS assembly NifU-like protein 771088 iscU 7329214 iscU Streptococcus pneumoniae ATCC 700669 FeS assembly NifU-like protein YP_002510801.1 770648 D 561276 CDS YP_002510802.1 221231650 7328088 771142..772554 1 NC_011900.1 FeS assembly protein SufB 772554 sufB 7328088 sufB Streptococcus pneumoniae ATCC 700669 FeS assembly protein SufB YP_002510802.1 771142 D 561276 CDS YP_002510803.1 221231651 7329159 complement(772753..773994) 1 NC_011900.1 D-alanyl-D-alanine carboxypeptidase 773994 7329159 SPN23F_07950 Streptococcus pneumoniae ATCC 700669 D-alanyl-D-alanine carboxypeptidase YP_002510803.1 772753 R 561276 CDS YP_002510804.1 221231652 7327802 774175..775206 1 NC_011900.1 hypothetical protein 775206 7327802 SPN23F_07960 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510804.1 774175 D 561276 CDS YP_002510805.1 221231653 7327632 776632..777372 1 NC_011900.1 DeoR family regulatory protein 777372 7327632 SPN23F_07970 Streptococcus pneumoniae ATCC 700669 DeoR family regulatory protein YP_002510805.1 776632 D 561276 CDS YP_002510806.1 221231654 7327804 777369..778280 1 NC_011900.1 1-phosphofructokinase 778280 fruK 7327804 fruK Streptococcus pneumoniae ATCC 700669 1-phosphofructokinase YP_002510806.1 777369 D 561276 CDS YP_002510807.1 221231655 7328565 778277..780229 1 NC_011900.1 fructose-specific phosphotransferase system (PTS), IIABC component 780229 fruA 7328565 fruA Streptococcus pneumoniae ATCC 700669 fructose-specific phosphotransferase system (PTS), IIABC component YP_002510807.1 778277 D 561276 CDS YP_002510808.1 221231656 7328564 780393..782618 1 NC_011900.1 DNA translocase FtsK 782618 7328564 SPN23F_08010 Streptococcus pneumoniae ATCC 700669 DNA translocase FtsK YP_002510808.1 780393 D 561276 CDS YP_002510809.1 221231657 7327805 complement(782769..783197) 1 NC_011900.1 hypothetical protein 783197 7327805 SPN23F_08020 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510809.1 782769 R 561276 CDS YP_002510810.1 221231658 7327806 783335..784477 1 NC_011900.1 cysteine desulfhydrase 784477 7327806 SPN23F_08030 Streptococcus pneumoniae ATCC 700669 cysteine desulfhydrase YP_002510810.1 783335 D 561276 CDS YP_002510811.1 221231659 7327807 784486..785700 1 NC_011900.1 Required for the synthesis of the thiazole moiety; thiamine biosynthesis protein ThiI 785700 thiI 7327807 thiI Streptococcus pneumoniae ATCC 700669 thiamine biosynthesis protein ThiI YP_002510811.1 784486 D 561276 CDS YP_002510812.1 221231660 7329170 785835..786659 1 NC_011900.1 esterase 786659 7329170 SPN23F_08050 Streptococcus pneumoniae ATCC 700669 esterase YP_002510812.1 785835 D 561276 CDS YP_002510813.1 221231661 7327808 786672..787838 1 NC_011900.1 hypothetical protein 787838 7327808 SPN23F_08060 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510813.1 786672 D 561276 CDS YP_002510814.1 221231662 7327809 788346..789839 1 NC_011900.1 type I RM modification enzyme 789839 7327809 SPN23F_08070 Streptococcus pneumoniae ATCC 700669 type I RM modification enzyme YP_002510814.1 788346 D 561276 CDS YP_002510815.1 221231663 7327810 789852..790394 1 NC_011900.1 type I RM modification enzyme 790394 7327810 SPN23F_08080 Streptococcus pneumoniae ATCC 700669 type I RM modification enzyme YP_002510815.1 789852 D 561276 CDS YP_002510816.1 221231664 7327811 790391..791509 1 NC_011900.1 type I RM modification enzyme 791509 7327811 SPN23F_08090 Streptococcus pneumoniae ATCC 700669 type I RM modification enzyme YP_002510816.1 790391 D 561276 CDS YP_002510817.1 221231665 7327812 791569..791805 1 NC_011900.1 hypothetical protein 791805 7327812 SPN23F_08100 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510817.1 791569 D 561276 CDS YP_002510818.1 221231666 7327813 791802..792215 1 NC_011900.1 Phage/plasmid maintenance toxin/antidote system protein (toxin) 792215 7327813 SPN23F_08110 Streptococcus pneumoniae ATCC 700669 Phage/plasmid maintenance toxin/antidote system protein (toxin) YP_002510818.1 791802 D 561276 CDS YP_002510819.1 221231667 7327814 792333..793298 1 NC_011900.1 integrase/recombinase 793298 7327814 SPN23F_08120 Streptococcus pneumoniae ATCC 700669 integrase/recombinase YP_002510819.1 792333 D 561276 CDS YP_002510820.1 221231668 7327815 793264..793845 1 NC_011900.1 type I RM modification enzyme 793845 7327815 SPN23F_08130 Streptococcus pneumoniae ATCC 700669 type I RM modification enzyme YP_002510820.1 793264 D 561276 CDS YP_002510821.1 221231669 7327816 793875..797225 1 NC_011900.1 type I restriction modification system restriction protein 797225 7327816 SPN23F_08140 Streptococcus pneumoniae ATCC 700669 type I restriction modification system restriction protein YP_002510821.1 793875 D 561276 CDS YP_002510822.1 221231670 7327817 complement(797731..798201) 1 NC_011900.1 arginine repressor 798201 argR 7327817 argR Streptococcus pneumoniae ATCC 700669 arginine repressor YP_002510822.1 797731 R 561276 CDS YP_002510823.1 221231671 7328655 complement(798218..800491) 1 NC_011900.1 catalyzes the removal of N-terminal dipeptides when proline is the penultimate residue; x-prolyl-dipeptidyl aminopeptidase 800491 pepXP 7328655 pepXP Streptococcus pneumoniae ATCC 700669 x-prolyl-dipeptidyl aminopeptidase YP_002510823.1 798218 R 561276 CDS YP_002510824.1 221231672 7327832 800837..803938 1 NC_011900.1 Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. Proposed to be responsible for the synthesis of the lagging strand. In the low GC gram positive bacteria this enzyme is less processive and more error prone than its counterpart in other bacteria.; DNA polymerase III DnaE 803938 dnaE 7327832 dnaE Streptococcus pneumoniae ATCC 700669 DNA polymerase III DnaE YP_002510824.1 800837 D 561276 CDS YP_002510825.1 221231673 7329240 804021..805028 1 NC_011900.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 805028 pfk 7329240 pfk Streptococcus pneumoniae ATCC 700669 6-phosphofructokinase YP_002510825.1 804021 D 561276 CDS YP_002510826.1 221231674 7327833 805087..806592 1 NC_011900.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 806592 pyk 7327833 pyk Streptococcus pneumoniae ATCC 700669 pyruvate kinase YP_002510826.1 805087 D 561276 CDS YP_002510827.1 221231675 7327818 808407..809279 1 NC_011900.1 lipoprotein 809279 7327818 SPN23F_08210 Streptococcus pneumoniae ATCC 700669 lipoprotein YP_002510827.1 808407 D 561276 CDS YP_002510828.1 221231676 7328862 complement(809386..809769) 1 NC_011900.1 IS1381 transposase 809769 7328862 SPN23F_08220 Streptococcus pneumoniae ATCC 700669 IS1381 transposase YP_002510828.1 809386 R 561276 CDS YP_002510829.1 221231677 7328864 809912..810223 1 NC_011900.1 hypothetical protein 810223 7328864 SPN23F_08230 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510829.1 809912 D 561276 CDS YP_002510830.1 221231678 7328865 810227..810943 1 NC_011900.1 hypothetical protein 810943 7328865 SPN23F_08240 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510830.1 810227 D 561276 CDS YP_002510831.1 221231679 7328866 complement(811073..811888) 1 NC_011900.1 hypothetical protein 811888 7328866 SPN23F_08250 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510831.1 811073 R 561276 CDS YP_002510832.1 221231680 7328867 complement(811885..812790) 1 NC_011900.1 permease 812790 7328867 SPN23F_08260 Streptococcus pneumoniae ATCC 700669 permease YP_002510832.1 811885 R 561276 CDS YP_002510833.1 221231681 7328868 complement(812791..812922) 1 NC_011900.1 hypothetical protein 812922 7328868 SPN23F_08270 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510833.1 812791 R 561276 CDS YP_002510834.1 221231682 7328869 complement(813036..813221) 1 NC_011900.1 hypothetical protein 813221 7328869 SPN23F_08280 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510834.1 813036 R 561276 CDS YP_002510835.1 221231683 7328870 813337..815466 1 NC_011900.1 transcription accessory protein 815466 7328870 SPN23F_08290 Streptococcus pneumoniae ATCC 700669 transcription accessory protein YP_002510835.1 813337 D 561276 CDS YP_002510836.1 221231684 7328871 815453..815902 1 NC_011900.1 hypothetical protein 815902 7328871 SPN23F_08300 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510836.1 815453 D 561276 CDS YP_002510837.1 221231685 7328872 815961..816233 1 NC_011900.1 hypothetical protein 816233 7328872 SPN23F_08310 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510837.1 815961 D 561276 CDS YP_002510838.1 221231686 7328873 complement(816281..816445) 1 NC_011900.1 hypothetical protein 816445 7328873 SPN23F_08320 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510838.1 816281 R 561276 CDS YP_002510839.1 221231687 7328874 complement(816587..816778) 1 NC_011900.1 hypothetical protein 816778 7328874 SPN23F_08321 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510839.1 816587 R 561276 CDS YP_002510840.1 221231688 7328875 817206..817964 1 NC_011900.1 ABC transporter ATP-binding protein 817964 7328875 SPN23F_08330 Streptococcus pneumoniae ATCC 700669 ABC transporter ATP-binding protein YP_002510840.1 817206 D 561276 CDS YP_002510841.1 221231689 7328876 817966..819954 1 NC_011900.1 ABC transporter permease 819954 7328876 SPN23F_08340 Streptococcus pneumoniae ATCC 700669 ABC transporter permease YP_002510841.1 817966 D 561276 CDS YP_002510842.1 221231690 7328880 822368..823843 1 NC_011900.1 arginine decarboxylase 823843 speA 7328880 speA Streptococcus pneumoniae ATCC 700669 arginine decarboxylase YP_002510842.1 822368 D 561276 CDS YP_002510843.1 221231691 7328882 824780..825640 1 NC_011900.1 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase 825640 speE 7328882 speE Streptococcus pneumoniae ATCC 700669 spermidine synthase YP_002510843.1 824780 D 561276 CDS YP_002510844.1 221231692 7329149 825637..826896 1 NC_011900.1 saccharopine dehydrogenase family protein 826896 7329149 SPN23F_08430 Streptococcus pneumoniae ATCC 700669 saccharopine dehydrogenase family protein YP_002510844.1 825637 D 561276 CDS YP_002510845.1 221231693 7328883 826896..828023 1 NC_011900.1 carboxynorspermidine decarboxylase 828023 7328883 SPN23F_08440 Streptococcus pneumoniae ATCC 700669 carboxynorspermidine decarboxylase YP_002510845.1 826896 D 561276 CDS YP_002510846.1 221231694 7328884 828020..829105 1 NC_011900.1 catalyzes the formation of carbamoylputrescine from agmatine in the arginine decarboxylase pathway of putrescine biosynthesis; agmatine deiminase 829105 7328884 SPN23F_08450 Streptococcus pneumoniae ATCC 700669 agmatine deiminase YP_002510846.1 828020 D 561276 CDS YP_002510847.1 221231695 7328885 829115..829990 1 NC_011900.1 carbon-nitrogen hydrolase family protein 829990 7328885 SPN23F_08460 Streptococcus pneumoniae ATCC 700669 carbon-nitrogen hydrolase family protein YP_002510847.1 829115 D 561276 CDS YP_002510848.1 221231696 7328886 complement(830171..830980) 1 NC_011900.1 haloacid dehalogenase-like hydrolase 830980 7328886 SPN23F_08470 Streptococcus pneumoniae ATCC 700669 haloacid dehalogenase-like hydrolase YP_002510848.1 830171 R 561276 CDS YP_002510849.1 221231697 7328887 831527..832198 1 NC_011900.1 hypothetical protein 832198 7328887 SPN23F_08480 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510849.1 831527 D 561276 CDS YP_002510850.1 221231698 7328888 832440..833348 1 NC_011900.1 LysR family transcriptional regulator 833348 7328888 SPN23F_08500 Streptococcus pneumoniae ATCC 700669 LysR family transcriptional regulator YP_002510850.1 832440 D 561276 CDS YP_002510851.1 221231699 7328889 833345..833806 1 NC_011900.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 833806 lspA 7328889 lspA Streptococcus pneumoniae ATCC 700669 lipoprotein signal peptidase YP_002510851.1 833345 D 561276 CDS YP_002510852.1 221231700 7328111 833796..834683 1 NC_011900.1 RNA pseudouridylate synthase 834683 7328111 SPN23F_08520 Streptococcus pneumoniae ATCC 700669 RNA pseudouridylate synthase YP_002510852.1 833796 D 561276 CDS YP_002510853.1 221231701 7328890 834686..836569 1 NC_011900.1 choline binding protein E 836569 cbpE 7328890 cbpE Streptococcus pneumoniae ATCC 700669 choline binding protein E YP_002510853.1 834686 D 561276 CDS YP_002510854.1 221231702 7329182 836670..837779 1 NC_011900.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 837779 proB 7329182 proB Streptococcus pneumoniae ATCC 700669 gamma-glutamyl kinase YP_002510854.1 836670 D 561276 CDS YP_002510855.1 221231703 7327877 837789..839051 1 NC_011900.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 839051 proA 7327877 proA Streptococcus pneumoniae ATCC 700669 gamma-glutamyl phosphate reductase YP_002510855.1 837789 D 561276 CDS YP_002510856.1 221231704 7327876 839055..839852 1 NC_011900.1 pyrroline-5-carboxylate reductase 839852 proC 7327876 proC Streptococcus pneumoniae ATCC 700669 pyrroline-5-carboxylate reductase YP_002510856.1 839055 D 561276 CDS YP_002510857.1 221231705 7327878 840072..840710 1 NC_011900.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 840710 tmk 7327878 tmk Streptococcus pneumoniae ATCC 700669 thymidylate kinase YP_002510857.1 840072 D 561276 CDS YP_002510858.1 221231706 7329178 840707..841597 1 NC_011900.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA.; DNA polymerase III subunit delta' 841597 holB 7329178 holB Streptococcus pneumoniae ATCC 700669 DNA polymerase III subunit delta' YP_002510858.1 840707 D 561276 CDS YP_002510859.1 221231707 7328073 841637..841954 1 NC_011900.1 in Bacillus subtilis this protein is involved in the negative regulation of DNA replication initiation; interacts with DnaN and DnaA; DNA replication intiation control protein YabA 841954 7328073 SPN23F_08590 Streptococcus pneumoniae ATCC 700669 DNA replication intiation control protein YabA YP_002510859.1 841637 D 561276 CDS YP_002510860.1 221231708 7328891 841957..842826 1 NC_011900.1 tetrapyrrole methylase 842826 7328891 SPN23F_08600 Streptococcus pneumoniae ATCC 700669 tetrapyrrole methylase YP_002510860.1 841957 D 561276 CDS YP_002510861.1 221231709 7328892 843053..843571 1 NC_011900.1 hypothetical protein 843571 7328892 SPN23F_08610 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510861.1 843053 D 561276 CDS YP_002510862.1 221231710 7328895 845667..847001 1 NC_011900.1 TrmFO; Gid; glucose-inhibited division protein; similar to GidA; the gene from Bacillus subtilis encodes a tRNA-methyltransferase that utilizes folate as the carbon donor and bound flavin as reductant; modifies tRNA at position 54 (uridine) of the T-psi loop to form a C5-methyluridine; tRNA (uracil-5-)-methyltransferase Gid 847001 7328895 SPN23F_08650 Streptococcus pneumoniae ATCC 700669 tRNA (uracil-5-)-methyltransferase Gid YP_002510862.1 845667 D 561276 CDS YP_002510863.1 221231711 7328896 847085..847822 1 NC_011900.1 Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 847822 pyrH 7328896 pyrH Streptococcus pneumoniae ATCC 700669 uridylate kinase YP_002510863.1 847085 D 561276 CDS YP_002510864.1 221231712 7327435 847831..848388 1 NC_011900.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 848388 frr 7327435 frr Streptococcus pneumoniae ATCC 700669 ribosome recycling factor YP_002510864.1 847831 D 561276 CDS YP_002510865.1 221231713 7329128 848409..849302 1 NC_011900.1 hypothetical protein 849302 7329128 SPN23F_08680 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510865.1 848409 D 561276 CDS YP_002510866.1 221231714 7328897 849311..849526 1 NC_011900.1 hypothetical protein 849526 7328897 SPN23F_08690 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510866.1 849311 D 561276 CDS YP_002510867.1 221231715 7328898 849612..850580 1 NC_011900.1 PhoH-like protein 850580 7328898 SPN23F_08700 Streptococcus pneumoniae ATCC 700669 PhoH-like protein YP_002510867.1 849612 D 561276 CDS YP_002510868.1 221231716 7328901 851277..851504 1 NC_011900.1 competence-related protein 851504 7328901 SPN23F_08740 Streptococcus pneumoniae ATCC 700669 competence-related protein YP_002510868.1 851277 D 561276 CDS YP_002510869.1 221231717 7328902 853191..853760 1 NC_011900.1 GNAT family acetyltransferase 853760 7328902 SPN23F_08780 Streptococcus pneumoniae ATCC 700669 GNAT family acetyltransferase YP_002510869.1 853191 D 561276 CDS YP_002510870.1 221231718 7328903 853828..854478 1 NC_011900.1 competence protein 854478 comEA 7328903 comEA Streptococcus pneumoniae ATCC 700669 competence protein YP_002510870.1 853828 D 561276 CDS YP_002510871.1 221231719 7329207 854462..856702 1 NC_011900.1 competence protein 856702 comEC 7329207 comEC Streptococcus pneumoniae ATCC 700669 competence protein YP_002510871.1 854462 D 561276 CDS YP_002510872.1 221231720 7329208 857101..857688 1 NC_011900.1 ABC transporter ATP-binding protein 857688 7329208 SPN23F_08820 Streptococcus pneumoniae ATCC 700669 ABC transporter ATP-binding protein YP_002510872.1 857101 D 561276 CDS YP_002510873.1 221231721 7328904 857692..858873 1 NC_011900.1 hypothetical protein 858873 7328904 SPN23F_08830 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510873.1 857692 D 561276 CDS YP_002510874.1 221231722 7328905 859153..859710 1 NC_011900.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 859710 infC 7328905 infC Streptococcus pneumoniae ATCC 700669 translation initiation factor IF-3 YP_002510874.1 859153 D 561276 CDS YP_002510875.1 221231723 7328087 859743..859943 1 NC_011900.1 50S ribosomal protein L35 859943 rpmI 7328087 rpmI Streptococcus pneumoniae ATCC 700669 50S ribosomal protein L35 YP_002510875.1 859743 D 561276 CDS YP_002510876.1 221231724 7329102 859995..860354 1 NC_011900.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 860354 rplT 7329102 rplT Streptococcus pneumoniae ATCC 700669 50S ribosomal protein L20 YP_002510876.1 859995 D 561276 CDS YP_002510877.1 221231725 7327487 860412..860792 1 NC_011900.1 lactoylglutathione lyase 860792 gloA 7327487 gloA Streptococcus pneumoniae ATCC 700669 lactoylglutathione lyase YP_002510877.1 860412 D 561276 CDS YP_002510878.1 221231726 7328607 861042..861842 1 NC_011900.1 responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the pyrD subunit to the ultimate electron acceptor NAD(+); dihydroorotate dehydrogenase electron transfer subunit 861842 pyrK 7328607 pyrK Streptococcus pneumoniae ATCC 700669 dihydroorotate dehydrogenase electron transfer subunit YP_002510878.1 861042 D 561276 CDS YP_002510879.1 221231727 7327436 861853..862791 1 NC_011900.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway, using a flavin nucleotide as an essential cofactor; subclass 1B is a heterotetramer consisting of two PyrDB subunits, similar to the PyrDA subunits and two PyrK subunits; dihydroorotate dehydrogenase 1B 862791 pyrD 7327436 pyrD Streptococcus pneumoniae ATCC 700669 dihydroorotate dehydrogenase 1B YP_002510879.1 861853 D 561276 CDS YP_002510880.1 221231728 7327431 862890..864866 1 NC_011900.1 endo-beta-N-acetylglucosaminidase 864866 lytB 7327431 lytB Streptococcus pneumoniae ATCC 700669 endo-beta-N-acetylglucosaminidase YP_002510880.1 862890 D 561276 CDS YP_002510881.1 221231729 7328114 complement(864927..866582) 1 NC_011900.1 fibronectin/fibrinogen-binding protein adherence and virulence protein A 866582 fbpS 7328114 fbpS Streptococcus pneumoniae ATCC 700669 fibronectin/fibrinogen-binding protein adherence and virulence protein A YP_002510881.1 864927 R 561276 CDS YP_002510882.1 221231730 7328552 866687..867184 1 NC_011900.1 metalloprotease 867184 7328552 SPN23F_08920 Streptococcus pneumoniae ATCC 700669 metalloprotease YP_002510882.1 866687 D 561276 CDS YP_002510883.1 221231731 7328906 867165..867560 1 NC_011900.1 diacylglycerol kinase 867560 dgk 7328906 dgk Streptococcus pneumoniae ATCC 700669 diacylglycerol kinase YP_002510883.1 867165 D 561276 CDS YP_002510884.1 221231732 7329230 867577..868476 1 NC_011900.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 868476 era 7329230 era Streptococcus pneumoniae ATCC 700669 GTP-binding protein Era YP_002510884.1 867577 D 561276 CDS YP_002510885.1 221231733 7329258 868525..869349 1 NC_011900.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 869349 fpg 7329258 fpg Streptococcus pneumoniae ATCC 700669 formamidopyrimidine-DNA glycosylase YP_002510885.1 868525 D 561276 CDS YP_002510886.1 221231734 7328562 869349..869954 1 NC_011900.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase 869954 coaE 7328562 coaE Streptococcus pneumoniae ATCC 700669 dephospho-CoA kinase YP_002510886.1 869349 D 561276 CDS YP_002510887.1 221231735 7329204 869941..871140 1 NC_011900.1 multi-drug resistance efflux pump 871140 pmrA 7329204 pmrA Streptococcus pneumoniae ATCC 700669 multi-drug resistance efflux pump YP_002510887.1 869941 D 561276 CDS YP_002510888.1 221231736 7327855 871329..871562 1 NC_011900.1 preprotein translocase subunit SecG 871562 secG 7327855 secG Streptococcus pneumoniae ATCC 700669 preprotein translocase subunit SecG YP_002510888.1 871329 D 561276 CDS YP_002510889.1 221231737 7329141 871664..874018 1 NC_011900.1 exoribonuclease R 874018 rnr 7329141 rnr Streptococcus pneumoniae ATCC 700669 exoribonuclease R YP_002510889.1 871664 D 561276 CDS YP_002510890.1 221231738 7327466 873981..874448 1 NC_011900.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 874448 smpB 7327466 smpB Streptococcus pneumoniae ATCC 700669 SsrA-binding protein YP_002510890.1 873981 D 561276 CDS YP_002510891.1 221231739 7329145 874464..875324 1 NC_011900.1 with TehA confers resistance to tellurite; tellurite resistance protein TehB 875324 7329145 SPN23F_09010 Streptococcus pneumoniae ATCC 700669 tellurite resistance protein TehB YP_002510891.1 874464 D 561276 CDS YP_002510892.1 221231740 7328907 875397..876350 1 NC_011900.1 competence protein CoiA-like family protein 876350 7328907 SPN23F_09020 Streptococcus pneumoniae ATCC 700669 competence protein CoiA-like family protein YP_002510892.1 875397 D 561276 CDS YP_002510893.1 221231741 7328908 876369..878171 1 NC_011900.1 oligopeptidase 878171 pepB 7328908 pepB Streptococcus pneumoniae ATCC 700669 oligopeptidase YP_002510893.1 876369 D 561276 CDS YP_002510894.1 221231742 7327824 878209..878886 1 NC_011900.1 O-methyltransferase 878886 7327824 SPN23F_09040 Streptococcus pneumoniae ATCC 700669 O-methyltransferase YP_002510894.1 878209 D 561276 CDS YP_002510895.1 221231743 7328909 878953..879894 1 NC_011900.1 cis/trans isomerase of peptidylprolyl; PPIase; membrane-bound lipoprotein; foldase protein PrsA 879894 prsA 7328909 prsA Streptococcus pneumoniae ATCC 700669 foldase protein PrsA YP_002510895.1 878953 D 561276 CDS YP_002510896.1 221231744 7328912 complement(881115..881735) 1 NC_011900.1 phosphoglycerate mutase family protein 881735 7328912 SPN23F_09090 Streptococcus pneumoniae ATCC 700669 phosphoglycerate mutase family protein YP_002510896.1 881115 R 561276 CDS YP_002510897.1 221231745 7328913 complement(881735..882217) 1 NC_011900.1 hypothetical protein 882217 7328913 SPN23F_09100 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510897.1 881735 R 561276 CDS YP_002510898.1 221231746 7328914 complement(882217..883059) 1 NC_011900.1 hypothetical protein 883059 7328914 SPN23F_09110 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510898.1 882217 R 561276 CDS YP_002510899.1 221231747 7328915 complement(883154..883954) 1 NC_011900.1 glycosyl hydrolase 883954 7328915 SPN23F_09120 Streptococcus pneumoniae ATCC 700669 glycosyl hydrolase YP_002510899.1 883154 R 561276 CDS YP_002510900.1 221231748 7328916 884050..885477 1 NC_011900.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 885477 glmU 7328916 glmU Streptococcus pneumoniae ATCC 700669 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase YP_002510900.1 884050 D 561276 CDS YP_002510901.1 221231749 7328589 885487..886032 1 NC_011900.1 ADP-ribose pyrophosphatase 886032 7328589 SPN23F_09140 Streptococcus pneumoniae ATCC 700669 ADP-ribose pyrophosphatase YP_002510901.1 885487 D 561276 CDS YP_002510902.1 221231750 7328917 886044..886358 1 NC_011900.1 hypothetical protein 886358 7328917 SPN23F_09150 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510902.1 886044 D 561276 CDS YP_002510903.1 221231751 7328918 886375..887067 1 NC_011900.1 enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 887067 mtnN 7328918 mtnN Streptococcus pneumoniae ATCC 700669 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase YP_002510903.1 886375 D 561276 CDS YP_002510904.1 221231752 7328387 887156..887635 1 NC_011900.1 DNA-binding protein 887635 7328387 SPN23F_09170 Streptococcus pneumoniae ATCC 700669 DNA-binding protein YP_002510904.1 887156 D 561276 CDS YP_002510905.1 221231753 7328919 887733..888323 1 NC_011900.1 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 888323 7328919 SPN23F_09180 Streptococcus pneumoniae ATCC 700669 DNA polymerase III subunit epsilon YP_002510905.1 887733 D 561276 CDS YP_002510906.1 221231754 7328920 888332..890095 1 NC_011900.1 glycerophosphodiester phosphodiesterase 890095 7328920 SPN23F_09190 Streptococcus pneumoniae ATCC 700669 glycerophosphodiester phosphodiesterase YP_002510906.1 888332 D 561276 CDS YP_002510907.1 221231755 7328922 891118..891318 1 NC_011900.1 hypothetical protein 891318 7328922 SPN23F_09220 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510907.1 891118 D 561276 CDS YP_002510908.1 221231756 7328924 891996..892703 1 NC_011900.1 cytochrome c-type biogenesis protein 892703 7328924 SPN23F_09250 Streptococcus pneumoniae ATCC 700669 cytochrome c-type biogenesis protein YP_002510908.1 891996 D 561276 CDS YP_002510909.1 221231757 7328926 892714..893271 1 NC_011900.1 redoxin family protein 893271 7328926 SPN23F_09260 Streptococcus pneumoniae ATCC 700669 redoxin family protein YP_002510909.1 892714 D 561276 CDS YP_002510910.1 221231758 7328927 893645..895036 1 NC_011900.1 amino acid permease 895036 7328927 SPN23F_09270 Streptococcus pneumoniae ATCC 700669 amino acid permease YP_002510910.1 893645 D 561276 CDS YP_002510911.1 221231759 7328928 895179..896096 1 NC_011900.1 laminin binding protein 896096 lmb 7328928 lmb Streptococcus pneumoniae ATCC 700669 laminin binding protein YP_002510911.1 895179 D 561276 CDS YP_002510912.1 221231760 7328110 896104..898620 1 NC_011900.1 pneumococcal histidine triad protein D (bvh-11-2) 898620 phtD 7328110 phtD Streptococcus pneumoniae ATCC 700669 pneumococcal histidine triad protein D (bvh-11-2) YP_002510912.1 896104 D 561276 CDS YP_002510913.1 221231761 7327848 898830..901949 1 NC_011900.1 pneumococcal histidine triad protein E (Bvh-3) 901949 phtE 7327848 phtE Streptococcus pneumoniae ATCC 700669 pneumococcal histidine triad protein E (Bvh-3) YP_002510913.1 898830 D 561276 CDS YP_002510914.1 221231762 7327850 902779..903348 1 NC_011900.1 pneumococcal histidine triad protein E truncation 903348 7327850 SPN23F_09310 Streptococcus pneumoniae ATCC 700669 pneumococcal histidine triad protein E truncation YP_002510914.1 902779 D 561276 CDS YP_002510915.1 221231763 7328930 complement(904308..905531) 1 NC_011900.1 catalyzes the release of the N-terminal amino acid from a tripeptide; peptidase T 905531 pepT 7328930 pepT Streptococcus pneumoniae ATCC 700669 peptidase T YP_002510915.1 904308 R 561276 CDS YP_002510916.1 221231764 7327830 905686..906780 1 NC_011900.1 ferrochelatase 906780 hemH 7327830 hemH Streptococcus pneumoniae ATCC 700669 ferrochelatase YP_002510916.1 905686 D 561276 CDS YP_002510917.1 221231765 7328068 complement(906822..907199) 1 NC_011900.1 large-conductance mechanosensitive channel 907199 mscL 7328068 mscL Streptococcus pneumoniae ATCC 700669 large-conductance mechanosensitive channel YP_002510917.1 906822 R 561276 CDS YP_002510918.1 221231766 7328134 complement(907281..907712) 1 NC_011900.1 GtrA-like protein 907712 7328134 SPN23F_09360 Streptococcus pneumoniae ATCC 700669 GtrA-like protein YP_002510918.1 907281 R 561276 CDS YP_002510919.1 221231767 7328931 907835..908344 1 NC_011900.1 hypothetical protein 908344 7328931 SPN23F_09370 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510919.1 907835 D 561276 CDS YP_002510920.1 221231768 7327636 909147..910223 1 NC_011900.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 910223 asd 7327636 asd Streptococcus pneumoniae ATCC 700669 aspartate-semialdehyde dehydrogenase YP_002510920.1 909147 D 561276 CDS YP_002510921.1 221231769 7328666 910279..911214 1 NC_011900.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase 911214 dapA 7328666 dapA Streptococcus pneumoniae ATCC 700669 dihydrodipicolinate synthase YP_002510921.1 910279 D 561276 CDS YP_002510922.1 221231770 7329221 complement(911261..912634) 1 NC_011900.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE 912634 trmE 7329221 trmE Streptococcus pneumoniae ATCC 700669 tRNA modification GTPase TrmE YP_002510922.1 911261 R 561276 CDS YP_002510923.1 221231771 7327586 complement(912770..912952) 1 NC_011900.1 4-OT; member of subfamily 5; forms a dimer; the function in the Escherichia coli cell is unknown; 4-oxalocrotonate tautomerase 912952 7327586 SPN23F_09410 Streptococcus pneumoniae ATCC 700669 4-oxalocrotonate tautomerase YP_002510923.1 912770 R 561276 CDS YP_002510924.1 221231772 7328933 913075..913665 1 NC_011900.1 catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 913665 tdk 7328933 tdk Streptococcus pneumoniae ATCC 700669 thymidine kinase YP_002510924.1 913075 D 561276 CDS YP_002510925.1 221231773 7329163 913662..914741 1 NC_011900.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 914741 prfA 7329163 prfA Streptococcus pneumoniae ATCC 700669 peptide chain release factor 1 YP_002510925.1 913662 D 561276 CDS YP_002510926.1 221231774 7327872 914741..915580 1 NC_011900.1 methyltransferase 915580 7327872 SPN23F_09440 Streptococcus pneumoniae ATCC 700669 methyltransferase YP_002510926.1 914741 D 561276 CDS YP_002510927.1 221231775 7328934 915564..916166 1 NC_011900.1 hypothetical protein 916166 7328934 SPN23F_09450 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510927.1 915564 D 561276 CDS YP_002510928.1 221231776 7328935 916168..916599 1 NC_011900.1 GNAT family acetyltransferase 916599 7328935 SPN23F_09460 Streptococcus pneumoniae ATCC 700669 GNAT family acetyltransferase YP_002510928.1 916168 D 561276 CDS YP_002510929.1 221231777 7328936 916661..917917 1 NC_011900.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 917917 glyA 7328936 glyA Streptococcus pneumoniae ATCC 700669 serine hydroxymethyltransferase YP_002510929.1 916661 D 561276 CDS YP_002510930.1 221231778 7328613 917925..918899 1 NC_011900.1 hypothetical protein 918899 7328613 SPN23F_09480 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510930.1 917925 D 561276 CDS YP_002510931.1 221231779 7328937 918899..919513 1 NC_011900.1 hypothetical protein 919513 7328937 SPN23F_09490 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510931.1 918899 D 561276 CDS YP_002510932.1 221231780 7328938 919587..920561 1 NC_011900.1 hypothetical protein 920561 7328938 SPN23F_09500 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510932.1 919587 D 561276 CDS YP_002510933.1 221231781 7328939 920635..922266 1 NC_011900.1 RNA methyltransferase 922266 7328939 SPN23F_09510 Streptococcus pneumoniae ATCC 700669 RNA methyltransferase YP_002510933.1 920635 D 561276 CDS YP_002510934.1 221231782 7328940 922465..922758 1 NC_011900.1 hypothetical protein 922758 7328940 SPN23F_09511 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510934.1 922465 D 561276 CDS YP_002510935.1 221231783 7328941 923004..923222 1 NC_011900.1 regulatory protein 923222 7328941 SPN23F_09520 Streptococcus pneumoniae ATCC 700669 regulatory protein YP_002510935.1 923004 D 561276 CDS YP_002510936.1 221231784 7328942 923615..924640 1 NC_011900.1 iron-siderophore binding lipoprotein 924640 7328942 SPN23F_09530 Streptococcus pneumoniae ATCC 700669 iron-siderophore binding lipoprotein YP_002510936.1 923615 D 561276 CDS YP_002510937.1 221231785 7328863 924630..925637 1 NC_011900.1 ferric siderophore ABC transporter permease 925637 7328863 SPN23F_09540 Streptococcus pneumoniae ATCC 700669 ferric siderophore ABC transporter permease YP_002510937.1 924630 D 561276 CDS YP_002510938.1 221231786 7328943 925637..926644 1 NC_011900.1 ferric enterobactin transport protein 926644 7328943 SPN23F_09550 Streptococcus pneumoniae ATCC 700669 ferric enterobactin transport protein YP_002510938.1 925637 D 561276 CDS YP_002510939.1 221231787 7328944 926644..927438 1 NC_011900.1 ferric siderophore ABC transporter ATP-binding protein 927438 7328944 SPN23F_09560 Streptococcus pneumoniae ATCC 700669 ferric siderophore ABC transporter ATP-binding protein YP_002510939.1 926644 D 561276 CDS YP_002510940.1 221231788 7328946 928006..928215 1 NC_011900.1 hypothetical protein 928215 7328946 SPN23F_09562 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510940.1 928006 D 561276 CDS YP_002510941.1 221231789 7328947 928340..928495 1 NC_011900.1 hypothetical protein 928495 7328947 SPN23F_09570 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510941.1 928340 D 561276 CDS YP_002510942.1 221231790 7328948 928674..928817 1 NC_011900.1 hypothetical protein 928817 7328948 SPN23F_09571 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510942.1 928674 D 561276 CDS YP_002510943.1 221231791 7328949 929179..929340 1 NC_011900.1 hypothetical protein 929340 7328949 SPN23F_09580 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510943.1 929179 D 561276 CDS YP_002510944.1 221231792 7328951 931379..931945 1 NC_011900.1 hypothetical protein 931945 7328951 SPN23F_09610 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510944.1 931379 D 561276 CDS YP_002510945.1 221231793 7328952 932267..932455 1 NC_011900.1 hypothetical protein 932455 7328952 SPN23F_09620 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510945.1 932267 D 561276 CDS YP_002510946.1 221231794 7328953 932517..933332 1 NC_011900.1 hypothetical protein 933332 7328953 SPN23F_09630 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510946.1 932517 D 561276 CDS YP_002510947.1 221231795 7328954 933332..934186 1 NC_011900.1 hydrolase 934186 7328954 SPN23F_09640 Streptococcus pneumoniae ATCC 700669 hydrolase YP_002510947.1 933332 D 561276 CDS YP_002510948.1 221231796 7328955 934298..935182 1 NC_011900.1 hypothetical protein 935182 7328955 SPN23F_09650 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510948.1 934298 D 561276 CDS YP_002510949.1 221231797 7328956 935345..937084 1 NC_011900.1 alpha-amylase 937084 7328956 SPN23F_09660 Streptococcus pneumoniae ATCC 700669 alpha-amylase YP_002510949.1 935345 D 561276 CDS YP_002510950.1 221231798 7328957 937170..937487 1 NC_011900.1 hypothetical protein 937487 7328957 SPN23F_09670 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510950.1 937170 D 561276 CDS YP_002510951.1 221231799 7328958 938259..938735 1 NC_011900.1 epsilon antitoxin 938735 7328958 SPN23F_09700 Streptococcus pneumoniae ATCC 700669 epsilon antitoxin YP_002510951.1 938259 D 561276 CDS YP_002510952.1 221231800 7328959 938735..939496 1 NC_011900.1 zeta-toxin 939496 7328959 SPN23F_09710 Streptococcus pneumoniae ATCC 700669 zeta-toxin YP_002510952.1 938735 D 561276 CDS YP_002510953.1 221231801 7328961 941158..941352 1 NC_011900.1 hypothetical protein 941352 7328961 SPN23F_09731 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510953.1 941158 D 561276 CDS YP_002510954.1 221231802 7328962 941512..941871 1 NC_011900.1 Tn5252, orf 10 protein 941871 7328962 SPN23F_09740 Streptococcus pneumoniae ATCC 700669 Tn5252, orf 10 protein YP_002510954.1 941512 D 561276 CDS YP_002510955.1 221231803 7328963 941881..942210 1 NC_011900.1 Tn5252, orf 9 protein 942210 7328963 SPN23F_09750 Streptococcus pneumoniae ATCC 700669 Tn5252, orf 9 protein YP_002510955.1 941881 D 561276 CDS YP_002510956.1 221231804 7328965 complement(944159..945010) 1 NC_011900.1 regulatory protein 945010 7328965 SPN23F_09790 Streptococcus pneumoniae ATCC 700669 regulatory protein YP_002510956.1 944159 R 561276 CDS YP_002510957.1 221231805 7328968 945774..947897 1 NC_011900.1 lantibiotic export protein 947897 7328968 SPN23F_09810 Streptococcus pneumoniae ATCC 700669 lantibiotic export protein YP_002510957.1 945774 D 561276 CDS YP_002510958.1 221231806 7328969 947910..948080 1 NC_011900.1 hypothetical protein 948080 7328969 SPN23F_09820 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510958.1 947910 D 561276 CDS YP_002510959.1 221231807 7328970 948114..948842 1 NC_011900.1 lantibiotic transport ATP-binding protein 948842 7328970 SPN23F_09830 Streptococcus pneumoniae ATCC 700669 lantibiotic transport ATP-binding protein YP_002510959.1 948114 D 561276 CDS YP_002510960.1 221231808 7328971 948835..949572 1 NC_011900.1 hypothetical protein 949572 7328971 SPN23F_09840 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510960.1 948835 D 561276 CDS YP_002510961.1 221231809 7328972 949585..950295 1 NC_011900.1 hypothetical protein 950295 7328972 SPN23F_09850 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510961.1 949585 D 561276 CDS YP_002510962.1 221231810 7328973 950837..951058 1 NC_011900.1 DNA_binding protein 951058 7328973 SPN23F_09860 Streptococcus pneumoniae ATCC 700669 DNA_binding protein YP_002510962.1 950837 D 561276 CDS YP_002510963.1 221231811 7328975 951956..953185 1 NC_011900.1 cell division protein 953185 ftsW 7328975 ftsW Streptococcus pneumoniae ATCC 700669 cell division protein YP_002510963.1 951956 D 561276 CDS YP_002510964.1 221231812 7328571 953205..955901 1 NC_011900.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase 955901 ppc 7328571 ppc Streptococcus pneumoniae ATCC 700669 phosphoenolpyruvate carboxylase YP_002510964.1 953205 D 561276 CDS YP_002510965.1 221231813 7329470 956314..957318 1 NC_011900.1 ABC transporter substrate-binding protein 957318 7329470 SPN23F_09900 Streptococcus pneumoniae ATCC 700669 ABC transporter substrate-binding protein YP_002510965.1 956314 D 561276 CDS YP_002510966.1 221231814 7328976 957387..958253 1 NC_011900.1 ABC transporter permease 958253 7328976 SPN23F_09910 Streptococcus pneumoniae ATCC 700669 ABC transporter permease YP_002510966.1 957387 D 561276 CDS YP_002510967.1 221231815 7328977 958250..959008 1 NC_011900.1 ABC transporter ATP-binding protein 959008 7328977 SPN23F_09920 Streptococcus pneumoniae ATCC 700669 ABC transporter ATP-binding protein YP_002510967.1 958250 D 561276 CDS YP_002510968.1 221231816 7328978 959098..960858 1 NC_011900.1 synthesizes RNA primers at the replication forks; DNA primase 960858 dnaG 7328978 dnaG Streptococcus pneumoniae ATCC 700669 DNA primase YP_002510968.1 959098 D 561276 CDS YP_002510969.1 221231817 7329241 960861..961970 1 NC_011900.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; primary sigma factor of bacterium; RNA polymerase sigma factor RpoD 961970 rpoD 7329241 rpoD Streptococcus pneumoniae ATCC 700669 RNA polymerase sigma factor RpoD YP_002510969.1 960861 D 561276 CDS YP_002510970.1 221231818 7329106 961984..962313 1 NC_011900.1 hypothetical protein 962313 7329106 SPN23F_09950 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510970.1 961984 D 561276 CDS YP_002510971.1 221231819 7328979 962428..963471 1 NC_011900.1 glycosyltransferase 963471 7328979 SPN23F_09960 Streptococcus pneumoniae ATCC 700669 glycosyltransferase YP_002510971.1 962428 D 561276 CDS YP_002510972.1 221231820 7328980 963487..964812 1 NC_011900.1 glycosyltransferase 964812 7328980 SPN23F_09970 Streptococcus pneumoniae ATCC 700669 glycosyltransferase YP_002510972.1 963487 D 561276 CDS YP_002510973.1 221231821 7328981 964843..965019 1 NC_011900.1 phage shock protein 965019 7328981 SPN23F_09980 Streptococcus pneumoniae ATCC 700669 phage shock protein YP_002510973.1 964843 D 561276 CDS YP_002510974.1 221231822 7328982 965078..965212 1 NC_011900.1 hypothetical protein 965212 7328982 SPN23F_09990 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510974.1 965078 D 561276 CDS YP_002510975.1 221231823 7328983 965282..966586 1 NC_011900.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 966586 obgE 7328983 obgE Streptococcus pneumoniae ATCC 700669 GTPase ObgE YP_002510975.1 965282 D 561276 CDS YP_002510976.1 221231824 7328984 966596..966754 1 NC_011900.1 hypothetical protein 966754 7328984 SPN23F_10010 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510976.1 966596 D 561276 CDS YP_002510977.1 221231825 7328985 967841..969100 1 NC_011900.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 969100 murZ 7328985 murZ Streptococcus pneumoniae ATCC 700669 UDP-N-acetylglucosamine 1-carboxyvinyltransferase YP_002510977.1 967841 D 561276 CDS YP_002510978.1 221231826 7328400 969116..969667 1 NC_011900.1 GNAT family acetyltransferase 969667 7328400 SPN23F_10030 Streptococcus pneumoniae ATCC 700669 GNAT family acetyltransferase YP_002510978.1 969116 D 561276 CDS YP_002510979.1 221231827 7328986 969660..970937 1 NC_011900.1 DNA-binding protein 970937 7328986 SPN23F_10040 Streptococcus pneumoniae ATCC 700669 DNA-binding protein YP_002510979.1 969660 D 561276 CDS YP_002510980.1 221231828 7328987 970953..971813 1 NC_011900.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; methionine aminopeptidase 971813 7328987 SPN23F_10050 Streptococcus pneumoniae ATCC 700669 methionine aminopeptidase YP_002510980.1 970953 D 561276 CDS YP_002510981.1 221231829 7328990 973187..975478 1 NC_011900.1 ATP-dependent DNA helicase 975478 pcrA 7328990 pcrA Streptococcus pneumoniae ATCC 700669 ATP-dependent DNA helicase YP_002510981.1 973187 D 561276 CDS YP_002510982.1 221231830 7328461 975521..976201 1 NC_011900.1 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase; DNA repair protein RadC 976201 radC 7328461 radC Streptococcus pneumoniae ATCC 700669 DNA repair protein RadC YP_002510982.1 975521 D 561276 CDS YP_002510983.1 221231831 7327440 complement(976198..976887) 1 NC_011900.1 peptidase 976887 7327440 SPN23F_10100 Streptococcus pneumoniae ATCC 700669 peptidase YP_002510983.1 976198 R 561276 CDS YP_002510984.1 221231832 7328991 complement(976905..977546) 1 NC_011900.1 modulates transcription in response to the NADH/NAD(+) redox state; redox-sensing transcriptional repressor Rex 977546 rex 7328991 rex Streptococcus pneumoniae ATCC 700669 redox-sensing transcriptional repressor Rex YP_002510984.1 976905 R 561276 CDS YP_002510985.1 221231833 7327451 complement(977629..977844) 1 NC_011900.1 hypothetical protein 977844 7327451 SPN23F_10120 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510985.1 977629 R 561276 CDS YP_002510986.1 221231834 7328992 complement(977852..978199) 1 NC_011900.1 hypothetical protein 978199 7328992 SPN23F_10130 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510986.1 977852 R 561276 CDS YP_002510987.1 221231835 7328993 complement(978204..979319) 1 NC_011900.1 cysteine desulfurase 979319 7328993 SPN23F_10140 Streptococcus pneumoniae ATCC 700669 cysteine desulfurase YP_002510987.1 978204 R 561276 CDS YP_002510988.1 221231836 7328994 complement(979329..980288) 1 NC_011900.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 980288 prsA2 7328994 prsA2 Streptococcus pneumoniae ATCC 700669 ribose-phosphate pyrophosphokinase YP_002510988.1 979329 R 561276 CDS YP_002510989.1 221231837 7327882 complement(980401..980970) 1 NC_011900.1 adenylate cyclase family protein 980970 7327882 SPN23F_10160 Streptococcus pneumoniae ATCC 700669 adenylate cyclase family protein YP_002510989.1 980401 R 561276 CDS YP_002510990.1 221231838 7328995 981098..981769 1 NC_011900.1 hypothetical protein 981769 7328995 SPN23F_10170 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510990.1 981098 D 561276 CDS YP_002510991.1 221231839 7328996 981753..982571 1 NC_011900.1 catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 982571 ppnK 7328996 ppnK Streptococcus pneumoniae ATCC 700669 inorganic polyphosphate/ATP-NAD kinase YP_002510991.1 981753 D 561276 CDS YP_002510992.1 221231840 7327871 982568..983464 1 NC_011900.1 RNA pseudouridylate synthase 983464 7327871 SPN23F_10190 Streptococcus pneumoniae ATCC 700669 RNA pseudouridylate synthase YP_002510992.1 982568 D 561276 CDS YP_002510993.1 221231841 7328997 983508..984482 1 NC_011900.1 in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta; phosphotransacetylase 984482 eutD 7328997 eutD Streptococcus pneumoniae ATCC 700669 phosphotransacetylase YP_002510993.1 983508 D 561276 CDS YP_002510994.1 221231842 7328999 complement(986251..986550) 1 NC_011900.1 hypothetical protein 986550 7328999 SPN23F_10240 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510994.1 986251 R 561276 CDS YP_002510995.1 221231843 7329000 986952..987656 1 NC_011900.1 hypothetical protein 987656 7329000 SPN23F_10250 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510995.1 986952 D 561276 CDS YP_002510996.1 221231844 7329001 987838..988152 1 NC_011900.1 50S ribosomal protein L21 988152 rplU 7329001 rplU Streptococcus pneumoniae ATCC 700669 50S ribosomal protein L21 YP_002510996.1 987838 D 561276 CDS YP_002510997.1 221231845 7327488 988168..988512 1 NC_011900.1 hypothetical protein 988512 7327488 SPN23F_10270 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002510997.1 988168 D 561276 CDS YP_002510998.1 221231846 7329002 988529..988822 1 NC_011900.1 involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 988822 rpmA 7329002 rpmA Streptococcus pneumoniae ATCC 700669 50S ribosomal protein L27 YP_002510998.1 988529 D 561276 CDS YP_002510999.1 221231847 7327492 989775..990692 1 NC_011900.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 990692 ribC 7327492 ribC Streptococcus pneumoniae ATCC 700669 bifunctional riboflavin kinase/FMN adenylyltransferase YP_002510999.1 989775 D 561276 CDS YP_002511000.1 221231848 7327453 complement(990785..991633) 1 NC_011900.1 hypothetical protein 991633 7327453 SPN23F_10320 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511000.1 990785 R 561276 CDS YP_002511001.1 221231849 7329003 991775..992614 1 NC_011900.1 hypothetical protein 992614 7329003 SPN23F_10330 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511001.1 991775 D 561276 CDS YP_002511002.1 221231850 7329004 992721..992996 1 NC_011900.1 DNA-binding protein HU 992996 hlpA 7329004 hlpA Streptococcus pneumoniae ATCC 700669 DNA-binding protein HU YP_002511002.1 992721 D 561276 CDS YP_002511003.1 221231851 7328071 993426..995327 1 NC_011900.1 ABC transporter ATP-binding protein 995327 7328071 SPN23F_10350 Streptococcus pneumoniae ATCC 700669 ABC transporter ATP-binding protein YP_002511003.1 993426 D 561276 CDS YP_002511004.1 221231852 7329005 995330..996193 1 NC_011900.1 DNA-binding protein 996193 7329005 SPN23F_10360 Streptococcus pneumoniae ATCC 700669 DNA-binding protein YP_002511004.1 995330 D 561276 CDS YP_002511005.1 221231853 7329006 996273..997451 1 NC_011900.1 membrane transport protein 997451 7329006 SPN23F_10370 Streptococcus pneumoniae ATCC 700669 membrane transport protein YP_002511005.1 996273 D 561276 CDS YP_002511006.1 221231854 7329007 997544..999502 1 NC_011900.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA 999502 ligA 7329007 ligA Streptococcus pneumoniae ATCC 700669 NAD-dependent DNA ligase LigA YP_002511006.1 997544 D 561276 CDS YP_002511007.1 221231855 7328109 999614..1001893 1 NC_011900.1 pullulanase 1001893 7328109 SPN23F_10390 Streptococcus pneumoniae ATCC 700669 pullulanase YP_002511007.1 999614 D 561276 CDS YP_002511008.1 221231856 7329008 1002438..1003862 1 NC_011900.1 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase 1003862 gapN 7329008 gapN Streptococcus pneumoniae ATCC 700669 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase YP_002511008.1 1002438 D 561276 CDS YP_002511009.1 221231857 7328585 1004345..1006273 1 NC_011900.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching enzyme 1006273 glgB 7328585 glgB Streptococcus pneumoniae ATCC 700669 glycogen branching enzyme YP_002511009.1 1004345 D 561276 CDS YP_002511010.1 221231858 7328597 1006263..1007405 1 NC_011900.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 1007405 glgC 7328597 glgC Streptococcus pneumoniae ATCC 700669 glucose-1-phosphate adenylyltransferase YP_002511010.1 1006263 D 561276 CDS YP_002511011.1 221231859 7328598 1007395..1008534 1 NC_011900.1 glycogen biosynthesis protein 1008534 7328598 SPN23F_10430 Streptococcus pneumoniae ATCC 700669 glycogen biosynthesis protein YP_002511011.1 1007395 D 561276 CDS YP_002511012.1 221231860 7329009 1008531..1009964 1 NC_011900.1 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose; glycogen synthase 1009964 glgA 7329009 glgA Streptococcus pneumoniae ATCC 700669 glycogen synthase YP_002511012.1 1008531 D 561276 CDS YP_002511013.1 221231861 7329010 1010677..1011480 1 NC_011900.1 May be a pseudogene; truncated by an internal deletion relative to some orthologues; glycerate kinase-family protein 1011480 7329010 SPN23F_10470 Streptococcus pneumoniae ATCC 700669 glycerate kinase-family protein YP_002511013.1 1010677 D 561276 CDS YP_002511014.1 221231862 7329012 complement(1011477..1011923) 1 NC_011900.1 hypothetical protein 1011923 7329012 SPN23F_10480 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511014.1 1011477 R 561276 CDS YP_002511015.1 221231863 7329013 1012087..1013391 1 NC_011900.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 1013391 eno 7329013 eno Streptococcus pneumoniae ATCC 700669 phosphopyruvate hydratase YP_002511015.1 1012087 D 561276 CDS YP_002511016.1 221231864 7329015 1015234..1018509 1 NC_011900.1 ATP-dependent exonuclease subunit B 1018509 addB 7329015 addB Streptococcus pneumoniae ATCC 700669 ATP-dependent exonuclease subunit B YP_002511016.1 1015234 D 561276 CDS YP_002511017.1 221231865 7328635 1018506..1022156 1 NC_011900.1 ATP-dependent exonuclease subunit A 1022156 addA 7328635 addA Streptococcus pneumoniae ATCC 700669 ATP-dependent exonuclease subunit A YP_002511017.1 1018506 D 561276 CDS YP_002511018.1 221231866 7328634 1022371..1023549 1 NC_011900.1 hypothetical protein 1023549 7328634 SPN23F_10570 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511018.1 1022371 D 561276 CDS YP_002511019.1 221231867 7329016 1023758..1030237 1 NC_011900.1 IgA-protease 1030237 zmpA 7329016 zmpA Streptococcus pneumoniae ATCC 700669 IgA-protease YP_002511019.1 1023758 D 561276 CDS YP_002511020.1 221231868 7329451 1030281..1035494 1 NC_011900.1 Zinc metalloprotease ZmpD 1035494 zmpD 7329451 zmpD Streptococcus pneumoniae ATCC 700669 Zinc metalloprotease ZmpD YP_002511020.1 1030281 D 561276 CDS YP_002511021.1 221231869 7329453 1035748..1036599 1 NC_011900.1 essential GTPase; functions in ribosome assembly; binds a unique part of the 23S rRNA; interacts with ribosomal protein L25(Ctc); ribosomal biogenesis GTPase 1036599 rbgA 7329453 rbgA Streptococcus pneumoniae ATCC 700669 ribosomal biogenesis GTPase YP_002511021.1 1035748 D 561276 CDS YP_002511022.1 221231870 7329017 1036586..1037365 1 NC_011900.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 1037365 rnhB 7329017 rnhB Streptococcus pneumoniae ATCC 700669 ribonuclease HII YP_002511022.1 1036586 D 561276 CDS YP_002511023.1 221231871 7327464 1037381..1038931 1 NC_011900.1 voltage gated chloride channel family protein 1038931 7327464 SPN23F_10620 Streptococcus pneumoniae ATCC 700669 voltage gated chloride channel family protein YP_002511023.1 1037381 D 561276 CDS YP_002511024.1 221231872 7329018 1039515..1040585 1 NC_011900.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerS; site-specific tyrosine recombinase XerS 1040585 xerS 7329018 xerS Streptococcus pneumoniae ATCC 700669 site-specific tyrosine recombinase XerS YP_002511024.1 1039515 D 561276 CDS YP_002511025.1 221231873 7329019 complement(1040650..1041639) 1 NC_011900.1 lipoate-protein ligase A 1041639 7329019 SPN23F_10640 Streptococcus pneumoniae ATCC 700669 lipoate-protein ligase A YP_002511025.1 1040650 R 561276 CDS YP_002511026.1 221231874 7329020 complement(1041703..1043388) 1 NC_011900.1 dihydrolipoamide dehydrogenase 1043388 acoL 7329020 acoL Streptococcus pneumoniae ATCC 700669 dihydrolipoamide dehydrogenase YP_002511026.1 1041703 R 561276 CDS YP_002511027.1 221231875 7328630 complement(1043452..1044495) 1 NC_011900.1 unlike PdhC proteins from other organisms, some Mycoplasma lack an N-terminal lipoyl domain; in Mycoplasma hyopneumonia the PdhD proteins contains the lipoyl domain; dihydrolipoamide acetyltransferase 1044495 acoC 7328630 acoC Streptococcus pneumoniae ATCC 700669 dihydrolipoamide acetyltransferase YP_002511027.1 1043452 R 561276 CDS YP_002511028.1 221231876 7328629 complement(1044713..1045705) 1 NC_011900.1 pyruvate dehydrogenase E1 component,beta subunit 1045705 pdhB 7328629 pdhB Streptococcus pneumoniae ATCC 700669 pyruvate dehydrogenase E1 component,beta subunit YP_002511028.1 1044713 R 561276 CDS YP_002511029.1 221231877 7327821 complement(1045721..1046689) 1 NC_011900.1 pyruvate dehydrogenase E1 component,alpha subunit 1046689 pdhA 7327821 pdhA Streptococcus pneumoniae ATCC 700669 pyruvate dehydrogenase E1 component,alpha subunit YP_002511029.1 1045721 R 561276 CDS YP_002511030.1 221231878 7327820 complement(1046843..1048204) 1 NC_011900.1 multidrug resistance protein 1048204 7327820 SPN23F_10690 Streptococcus pneumoniae ATCC 700669 multidrug resistance protein YP_002511030.1 1046843 R 561276 CDS YP_002511031.1 221231879 7329021 complement(1048489..1049757) 1 NC_011900.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase 1049757 pyrC 7329021 pyrC Streptococcus pneumoniae ATCC 700669 dihydroorotase YP_002511031.1 1048489 R 561276 CDS YP_002511032.1 221231880 7327429 complement(1049770..1050234) 1 NC_011900.1 mutator MutX protein (7,8-dihydro-8-oxoguanine-triphosphatase) 1050234 mutX 7327429 mutX Streptococcus pneumoniae ATCC 700669 mutator MutX protein (7,8-dihydro-8-oxoguanine-triphosphatase) YP_002511032.1 1049770 R 561276 CDS YP_002511033.1 221231881 7328404 complement(1050244..1050897) 1 NC_011900.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 1050897 ung 7328404 ung Streptococcus pneumoniae ATCC 700669 uracil-DNA glycosylase YP_002511033.1 1050244 R 561276 CDS YP_002511034.1 221231882 7329420 complement(1051033..1051680) 1 NC_011900.1 hypothetical protein 1051680 7329420 SPN23F_10730 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511034.1 1051033 R 561276 CDS YP_002511035.1 221231883 7329673 complement(1051694..1052407) 1 NC_011900.1 haloacid dehalogenase-like hydrolase 1052407 7329673 SPN23F_10740 Streptococcus pneumoniae ATCC 700669 haloacid dehalogenase-like hydrolase YP_002511035.1 1051694 R 561276 CDS YP_002511036.1 221231884 7327661 complement(1052866..1053240) 1 NC_011900.1 phosphotransferase mannnose-specific family component IIA 1053240 7327661 SPN23F_10750 Streptococcus pneumoniae ATCC 700669 phosphotransferase mannnose-specific family component IIA YP_002511036.1 1052866 R 561276 CDS YP_002511037.1 221231885 7327662 complement(1053659..1056181) 1 NC_011900.1 streptococcal histidine triad protein PhpA 1056181 phpA 7327662 phpA Streptococcus pneumoniae ATCC 700669 streptococcal histidine triad protein PhpA YP_002511037.1 1053659 R 561276 CDS YP_002511038.1 221231886 7327847 complement(1056435..1058168) 1 NC_011900.1 phosphoenolpyruvate-protein phosphotransferase 1058168 pstI 7327847 pstI Streptococcus pneumoniae ATCC 700669 phosphoenolpyruvate-protein phosphotransferase YP_002511038.1 1056435 R 561276 CDS YP_002511039.1 221231887 7327888 complement(1058174..1058437) 1 NC_011900.1 phosphocarrier protein HPr 1058437 ptsH 7327888 ptsH Streptococcus pneumoniae ATCC 700669 phosphocarrier protein HPr YP_002511039.1 1058174 R 561276 CDS YP_002511040.1 221231888 7327893 1058788..1059006 1 NC_011900.1 glutaredoxin-like protein 1059006 nrdH 7327893 nrdH Streptococcus pneumoniae ATCC 700669 glutaredoxin-like protein YP_002511040.1 1058788 D 561276 CDS YP_002511041.1 221231889 7328424 1059087..1061246 1 NC_011900.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 1061246 7328424 SPN23F_10810 Streptococcus pneumoniae ATCC 700669 ribonucleotide-diphosphate reductase subunit alpha YP_002511041.1 1059087 D 561276 CDS YP_002511042.1 221231890 7327663 1061434..1062396 1 NC_011900.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 1062396 nrdF 7327663 nrdF Streptococcus pneumoniae ATCC 700669 ribonucleotide-diphosphate reductase subunit beta YP_002511042.1 1061434 D 561276 CDS YP_002511043.1 221231891 7327664 1062684..1063445 1 NC_011900.1 lactose phosphotransferase system repressor 1 1063445 lacR1 7327664 lacR1 Streptococcus pneumoniae ATCC 700669 lactose phosphotransferase system repressor 1 YP_002511043.1 1062684 D 561276 CDS YP_002511044.1 221231892 7328098 complement(1063808..1065214) 1 NC_011900.1 catalyzes the formation of 6-phospho-galactose from a 6-phospho-beta-galactoside; 6-phospho-beta-galactosidase 1065214 lacG2 7328098 lacG2 Streptococcus pneumoniae ATCC 700669 6-phospho-beta-galactosidase YP_002511044.1 1063808 R 561276 CDS YP_002511045.1 221231893 7328097 complement(1065429..1067123) 1 NC_011900.1 lactose-specific phosphotransferase system (PTS), IIBC component 2 1067123 lacE2 7328097 lacE2 Streptococcus pneumoniae ATCC 700669 lactose-specific phosphotransferase system (PTS), IIBC component 2 YP_002511045.1 1065429 R 561276 CDS YP_002511046.1 221231894 7328095 complement(1067125..1067442) 1 NC_011900.1 PTS system, lactose-specific IIA component 1067442 lacF 7328095 lacF Streptococcus pneumoniae ATCC 700669 PTS system, lactose-specific IIA component YP_002511046.1 1067125 R 561276 CDS YP_002511047.1 221231895 7328096 complement(1067478..1068314) 1 NC_011900.1 transcription antiterminator LacT 2 1068314 lacT2 7328096 lacT2 Streptococcus pneumoniae ATCC 700669 transcription antiterminator LacT 2 YP_002511047.1 1067478 R 561276 CDS YP_002511048.1 221231896 7328099 complement(1068548..1069528) 1 NC_011900.1 catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in Streptococcus pyogenes there are two paralogs of tagatose-bisphosphate aldolase, encoded by lacD1 and lacD2; expression of lacD1 is highly regulated by environmental conditions while lacD2 specializes in an efficient utilization of carbohydrate sources; tagatose 1,6-diphosphate aldolase 1069528 lacD2 7328099 lacD2 Streptococcus pneumoniae ATCC 700669 tagatose 1,6-diphosphate aldolase YP_002511048.1 1068548 R 561276 CDS YP_002511049.1 221231897 7328094 complement(1069530..1070459) 1 NC_011900.1 catalyzes the formation of tagatose 1,6-bisphosphate from tagatose 6-phosphate and ATP; tagatose-6-phosphate kinase 1070459 lacC2 7328094 lacC2 Streptococcus pneumoniae ATCC 700669 tagatose-6-phosphate kinase YP_002511049.1 1069530 R 561276 CDS YP_002511050.1 221231898 7328093 complement(1070470..1070985) 1 NC_011900.1 catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; galactose-6-phosphate isomerase subunit LacB 1070985 lacB1 7328093 lacB1 Streptococcus pneumoniae ATCC 700669 galactose-6-phosphate isomerase subunit LacB YP_002511050.1 1070470 R 561276 CDS YP_002511051.1 221231899 7328092 complement(1071016..1071441) 1 NC_011900.1 catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; tagatose pathway for galactose utilization; galactose-6-phosphate isomerase subunit LacA 1071441 lacA 7328092 lacA Streptococcus pneumoniae ATCC 700669 galactose-6-phosphate isomerase subunit LacA YP_002511051.1 1071016 R 561276 CDS YP_002511052.1 221231900 7327667 complement(1073263..1073739) 1 NC_011900.1 sugar phosphotransferase system (PTS), IIA component 1073739 7327667 SPN23F_10980 Streptococcus pneumoniae ATCC 700669 sugar phosphotransferase system (PTS), IIA component YP_002511052.1 1073263 R 561276 CDS YP_002511053.1 221231901 7327668 complement(1074152..1075975) 1 NC_011900.1 binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 1075975 lepA 7327668 lepA Streptococcus pneumoniae ATCC 700669 GTP-binding protein LepA YP_002511053.1 1074152 R 561276 CDS YP_002511054.1 221231902 7328102 complement(1076054..1076782) 1 NC_011900.1 Calcineurin-like phosphoesterase 1076782 7328102 SPN23F_11010 Streptococcus pneumoniae ATCC 700669 Calcineurin-like phosphoesterase YP_002511054.1 1076054 R 561276 CDS YP_002511055.1 221231903 7327669 complement(1076784..1078451) 1 NC_011900.1 DNA repair protein 1078451 recN 7327669 recN Streptococcus pneumoniae ATCC 700669 DNA repair protein YP_002511055.1 1076784 R 561276 CDS YP_002511056.1 221231904 7327445 complement(1078458..1078889) 1 NC_011900.1 repressor protein 1078889 7327445 SPN23F_11030 Streptococcus pneumoniae ATCC 700669 repressor protein YP_002511056.1 1078458 R 561276 CDS YP_002511057.1 221231905 7327670 complement(1078882..1079697) 1 NC_011900.1 hemolysin-like protein 1079697 7327670 SPN23F_11040 Streptococcus pneumoniae ATCC 700669 hemolysin-like protein YP_002511057.1 1078882 R 561276 CDS YP_002511058.1 221231906 7327671 complement(1079690..1080565) 1 NC_011900.1 geranyltranstransferase 1080565 fps 7327671 fps Streptococcus pneumoniae ATCC 700669 geranyltranstransferase YP_002511058.1 1079690 R 561276 CDS YP_002511059.1 221231907 7328563 complement(1080562..1080774) 1 NC_011900.1 catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit 1080774 xseB 7328563 xseB Streptococcus pneumoniae ATCC 700669 exodeoxyribonuclease VII small subunit YP_002511059.1 1080562 R 561276 CDS YP_002511060.1 221231908 7329450 complement(1080752..1082092) 1 NC_011900.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 1082092 xseA 7329450 xseA Streptococcus pneumoniae ATCC 700669 exodeoxyribonuclease VII large subunit YP_002511060.1 1080752 R 561276 CDS YP_002511061.1 221231909 7329449 complement(1082220..1082858) 1 NC_011900.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase 1082858 udk 7329449 udk Streptococcus pneumoniae ATCC 700669 uridine kinase YP_002511061.1 1082220 R 561276 CDS YP_002511062.1 221231910 7327659 complement(1082966..1083268) 1 NC_011900.1 bacteriocin immunity protein 1083268 7327659 SPN23F_11090 Streptococcus pneumoniae ATCC 700669 bacteriocin immunity protein YP_002511062.1 1082966 R 561276 CDS YP_002511063.1 221231911 7327672 complement(1083509..1084387) 1 NC_011900.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B 1084387 truB 7327672 truB Streptococcus pneumoniae ATCC 700669 tRNA pseudouridine synthase B YP_002511063.1 1083509 R 561276 CDS YP_002511064.1 221231912 7327654 complement(1084397..1085671) 1 NC_011900.1 hypothetical protein 1085671 7327654 SPN23F_11110 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511064.1 1084397 R 561276 CDS YP_002511065.1 221231913 7327674 complement(1087174..1087971) 1 NC_011900.1 formate/nitrate transport protein 1087971 7327674 SPN23F_11140 Streptococcus pneumoniae ATCC 700669 formate/nitrate transport protein YP_002511065.1 1087174 R 561276 CDS YP_002511066.1 221231914 7327675 complement(1088215..1088958) 1 NC_011900.1 sortase SrtA 1088958 srtA 7327675 srtA Streptococcus pneumoniae ATCC 700669 sortase SrtA YP_002511066.1 1088215 R 561276 CDS YP_002511067.1 221231915 7329153 complement(1088958..1091426) 1 NC_011900.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A 1091426 gyrA 7329153 gyrA Streptococcus pneumoniae ATCC 700669 DNA gyrase subunit A YP_002511067.1 1088958 R 561276 CDS YP_002511068.1 221231916 7328065 1091620..1092606 1 NC_011900.1 Converts (S)-lactate and NAD(+) to pyruvate and NADH; L-lactate dehydrogenase 1092606 ldh 7328065 ldh Streptococcus pneumoniae ATCC 700669 L-lactate dehydrogenase YP_002511068.1 1091620 D 561276 CDS YP_002511069.1 221231917 7328101 complement(1092854..1093627) 1 NC_011900.1 ion channel transport protein 1093627 7328101 SPN23F_11180 Streptococcus pneumoniae ATCC 700669 ion channel transport protein YP_002511069.1 1092854 R 561276 CDS YP_002511070.1 221231918 7327676 complement(1093674..1093928) 1 NC_011900.1 plasmid addiction system, toxin protein 1093928 7327676 SPN23F_11190 Streptococcus pneumoniae ATCC 700669 plasmid addiction system, toxin protein YP_002511070.1 1093674 R 561276 CDS YP_002511071.1 221231919 7327677 complement(1093930..1094172) 1 NC_011900.1 hypothetical protein 1094172 7327677 SPN23F_11200 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511071.1 1093930 R 561276 CDS YP_002511072.1 221231920 7327678 complement(1094263..1095072) 1 NC_011900.1 metallo-beta-lactamase superfamily protein 1095072 vicX 7327678 vicX Streptococcus pneumoniae ATCC 700669 metallo-beta-lactamase superfamily protein YP_002511072.1 1094263 R 561276 CDS YP_002511073.1 221231921 7329431 complement(1095074..1096423) 1 NC_011900.1 sensor histidine kinase 1096423 vicK 7329431 vicK Streptococcus pneumoniae ATCC 700669 sensor histidine kinase YP_002511073.1 1095074 R 561276 CDS YP_002511074.1 221231922 7329429 complement(1096416..1097120) 1 NC_011900.1 response regulator protein 1097120 vicR 7329429 vicR Streptococcus pneumoniae ATCC 700669 response regulator protein YP_002511074.1 1096416 R 561276 CDS YP_002511075.1 221231923 7329430 complement(1097175..1098350) 1 NC_011900.1 A/G-specific adenine glycosylase 1098350 mutY 7329430 mutY Streptococcus pneumoniae ATCC 700669 A/G-specific adenine glycosylase YP_002511075.1 1097175 R 561276 CDS YP_002511076.1 221231924 7328405 complement(1098678..1100348) 1 NC_011900.1 catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate; formate--tetrahydrofolate ligase 1100348 fhs1 7328405 fhs1 Streptococcus pneumoniae ATCC 700669 formate--tetrahydrofolate ligase YP_002511076.1 1098678 R 561276 CDS YP_002511077.1 221231925 7328554 1100578..1101267 1 NC_011900.1 phosphopantothenate--cysteine ligase 1101267 dpfB 7328554 dpfB Streptococcus pneumoniae ATCC 700669 phosphopantothenate--cysteine ligase YP_002511077.1 1100578 D 561276 CDS YP_002511078.1 221231926 7329247 1101279..1101830 1 NC_011900.1 decarboxylates 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine.; phosphopantothenoylcysteine decarboxylase 1101830 coaC 7329247 coaC Streptococcus pneumoniae ATCC 700669 phosphopantothenoylcysteine decarboxylase YP_002511078.1 1101279 D 561276 CDS YP_002511079.1 221231927 7329202 1101814..1102377 1 NC_011900.1 hypothetical protein 1102377 7329202 SPN23F_11280 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511079.1 1101814 D 561276 CDS YP_002511080.1 221231928 7327679 1102659..1103186 1 NC_011900.1 hypothetical protein 1103186 7327679 SPN23F_11290 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511080.1 1102659 D 561276 CDS YP_002511081.1 221231929 7327680 1103198..1103713 1 NC_011900.1 small-molecule-binding protein 1103713 7327680 SPN23F_11300 Streptococcus pneumoniae ATCC 700669 small-molecule-binding protein YP_002511081.1 1103198 D 561276 CDS YP_002511082.1 221231930 7327681 complement(1103710..1104177) 1 NC_011900.1 MutT/NUDIX hydrolase family protein 1104177 7327681 SPN23F_11310 Streptococcus pneumoniae ATCC 700669 MutT/NUDIX hydrolase family protein YP_002511082.1 1103710 R 561276 CDS YP_002511083.1 221231931 7327682 complement(1104251..1104739) 1 NC_011900.1 GNAT family acetyltransferase 1104739 7327682 SPN23F_11320 Streptococcus pneumoniae ATCC 700669 GNAT family acetyltransferase YP_002511083.1 1104251 R 561276 CDS YP_002511084.1 221231932 7327683 complement(1104705..1105268) 1 NC_011900.1 hypothetical protein 1105268 7327683 SPN23F_11330 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511084.1 1104705 R 561276 CDS YP_002511085.1 221231933 7327684 complement(1105278..1107266) 1 NC_011900.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 1107266 uvrB 7327684 uvrB Streptococcus pneumoniae ATCC 700669 excinuclease ABC subunit B YP_002511085.1 1105278 R 561276 CDS YP_002511086.1 221231934 7329424 complement(1107343..1108296) 1 NC_011900.1 CAAX amino terminal protease family protein 1108296 7329424 SPN23F_11350 Streptococcus pneumoniae ATCC 700669 CAAX amino terminal protease family protein YP_002511086.1 1107343 R 561276 CDS YP_002511087.1 221231935 7327685 1108469..1110634 1 NC_011900.1 glutamine ABC transporter,glutamine-binding protein/permease protein 1110634 7327685 SPN23F_11360 Streptococcus pneumoniae ATCC 700669 glutamine ABC transporter,glutamine-binding protein/permease protein YP_002511087.1 1108469 D 561276 CDS YP_002511088.1 221231936 7327686 1110634..1111374 1 NC_011900.1 glutamine ABC transporter ATP-binding protein 1 1111374 glnQ1 7327686 glnQ1 Streptococcus pneumoniae ATCC 700669 glutamine ABC transporter ATP-binding protein 1 YP_002511088.1 1110634 D 561276 CDS YP_002511089.1 221231937 7328603 1111523..1113010 1 NC_011900.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 1113010 zwf 7328603 zwf Streptococcus pneumoniae ATCC 700669 glucose-6-phosphate 1-dehydrogenase YP_002511089.1 1111523 D 561276 CDS YP_002511090.1 221231938 7329454 complement(1113056..1114345) 1 NC_011900.1 signal recognition particle 54 FtsY 1114345 ftsY 7329454 ftsY Streptococcus pneumoniae ATCC 700669 signal recognition particle 54 FtsY YP_002511090.1 1113056 R 561276 CDS YP_002511091.1 221231939 7328573 complement(1114349..1115167) 1 NC_011900.1 haloacid dehalogenase-like hydrolase 1115167 7328573 SPN23F_11400 Streptococcus pneumoniae ATCC 700669 haloacid dehalogenase-like hydrolase YP_002511091.1 1114349 R 561276 CDS YP_002511092.1 221231940 7327687 complement(1115167..1115961) 1 NC_011900.1 haloacid dehalogenase-like hydrolase 1115961 7327687 SPN23F_11410 Streptococcus pneumoniae ATCC 700669 haloacid dehalogenase-like hydrolase YP_002511092.1 1115167 R 561276 CDS YP_002511093.1 221231941 7327688 complement(1115958..1119497) 1 NC_011900.1 chromosome partition protein 1119497 smc 7327688 smc Streptococcus pneumoniae ATCC 700669 chromosome partition protein YP_002511093.1 1115958 R 561276 CDS YP_002511094.1 221231942 7329144 complement(1119488..1120186) 1 NC_011900.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 1120186 rnc 7329144 rnc Streptococcus pneumoniae ATCC 700669 ribonuclease III YP_002511094.1 1119488 R 561276 CDS YP_002511095.1 221231943 7327591 complement(1120504..1121490) 1 NC_011900.1 guanosine 5'-monophosphate oxidoreductase 1121490 7327591 SPN23F_11440 Streptococcus pneumoniae ATCC 700669 guanosine 5'-monophosphate oxidoreductase YP_002511095.1 1120504 R 561276 CDS YP_002511096.1 221231944 7327689 complement(1121724..1122962) 1 NC_011900.1 hypothetical protein 1122962 7327689 SPN23F_11450 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511096.1 1121724 R 561276 CDS YP_002511097.1 221231945 7327690 complement(1122949..1124862) 1 NC_011900.1 endonuclease 1124862 7327690 SPN23F_11460 Streptococcus pneumoniae ATCC 700669 endonuclease YP_002511097.1 1122949 R 561276 CDS YP_002511098.1 221231946 7327692 complement(1125809..1126168) 1 NC_011900.1 hypothetical protein 1126168 7327692 SPN23F_11500 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511098.1 1125809 R 561276 CDS YP_002511099.1 221231947 7327693 complement(1126172..1126441) 1 NC_011900.1 hypothetical protein 1126441 7327693 SPN23F_11510 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511099.1 1126172 R 561276 CDS YP_002511100.1 221231948 7327694 complement(1126438..1127475) 1 NC_011900.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase 1127475 leuB 7327694 leuB Streptococcus pneumoniae ATCC 700669 3-isopropylmalate dehydrogenase YP_002511100.1 1126438 R 561276 CDS YP_002511101.1 221231949 7327695 complement(1128600..1129256) 1 NC_011900.1 hypothetical protein 1129256 7327695 SPN23F_11550 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511101.1 1128600 R 561276 CDS YP_002511102.1 221231950 7327696 complement(1129300..1129932) 1 NC_011900.1 CutC family protein 1129932 7327696 SPN23F_11560 Streptococcus pneumoniae ATCC 700669 CutC family protein YP_002511102.1 1129300 R 561276 CDS YP_002511103.1 221231951 7327697 complement(1130025..1130384) 1 NC_011900.1 hypothetical protein 1130384 7327697 SPN23F_11570 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511103.1 1130025 R 561276 CDS YP_002511104.1 221231952 7327698 complement(1130490..1132577) 1 NC_011900.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I 1132577 topA 7327698 topA Streptococcus pneumoniae ATCC 700669 DNA topoisomerase I YP_002511104.1 1130490 R 561276 CDS YP_002511105.1 221231953 7329179 complement(1132744..1133787) 1 NC_011900.1 hypothetical protein 1133787 7329179 SPN23F_11590 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511105.1 1132744 R 561276 CDS YP_002511106.1 221231954 7327699 complement(1134676..1135524) 1 NC_011900.1 SMF family protein 1135524 7327699 SPN23F_11600 Streptococcus pneumoniae ATCC 700669 SMF family protein YP_002511106.1 1134676 R 561276 CDS YP_002511107.1 221231955 7327700 complement(1135620..1136309) 1 NC_011900.1 CTP:phosphocholine cytidylyltransferase 1136309 licC 7327700 licC Streptococcus pneumoniae ATCC 700669 CTP:phosphocholine cytidylyltransferase YP_002511107.1 1135620 R 561276 CDS YP_002511108.1 221231956 7328107 complement(1136321..1137199) 1 NC_011900.1 LicB-family membrane protein 1137199 7328107 SPN23F_11620 Streptococcus pneumoniae ATCC 700669 LicB-family membrane protein YP_002511108.1 1136321 R 561276 CDS YP_002511109.1 221231957 7327701 complement(1137189..1138058) 1 NC_011900.1 kinase 1138058 7327701 SPN23F_11630 Streptococcus pneumoniae ATCC 700669 kinase YP_002511109.1 1137189 R 561276 CDS YP_002511110.1 221231958 7327702 complement(1138075..1139097) 1 NC_011900.1 zinc-binding dehydrogenase 1139097 7327702 SPN23F_11640 Streptococcus pneumoniae ATCC 700669 zinc-binding dehydrogenase YP_002511110.1 1138075 R 561276 CDS YP_002511111.1 221231959 7327703 complement(1139102..1139809) 1 NC_011900.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 1139809 ispD 7327703 ispD Streptococcus pneumoniae ATCC 700669 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase YP_002511111.1 1139102 R 561276 CDS YP_002511112.1 221231960 7327704 1140145..1141632 1 NC_011900.1 polysaccharide biosynthesis flippase 1141632 7327704 SPN23F_11660 Streptococcus pneumoniae ATCC 700669 polysaccharide biosynthesis flippase YP_002511112.1 1140145 D 561276 CDS YP_002511113.1 221231961 7327705 1141642..1142445 1 NC_011900.1 phosphotransferase LicD1 1142445 7327705 SPN23F_11670 Streptococcus pneumoniae ATCC 700669 phosphotransferase LicD1 YP_002511113.1 1141642 D 561276 CDS YP_002511114.1 221231962 7327706 1142447..1143256 1 NC_011900.1 phosphotransferase LicD2 1143256 7327706 SPN23F_11680 Streptococcus pneumoniae ATCC 700669 phosphotransferase LicD2 YP_002511114.1 1142447 D 561276 CDS YP_002511115.1 221231963 7327707 complement(1143531..1146707) 1 NC_011900.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 1146707 carB 7327707 carB Streptococcus pneumoniae ATCC 700669 carbamoyl phosphate synthase large subunit YP_002511115.1 1143531 R 561276 CDS YP_002511116.1 221231964 7328701 complement(1147019..1148098) 1 NC_011900.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 1148098 carA 7328701 carA Streptococcus pneumoniae ATCC 700669 carbamoyl phosphate synthase small subunit YP_002511116.1 1147019 R 561276 CDS YP_002511117.1 221231965 7328700 complement(1148148..1149071) 1 NC_011900.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase catalytic subunit 1149071 pyrB 7328700 pyrB Streptococcus pneumoniae ATCC 700669 aspartate carbamoyltransferase catalytic subunit YP_002511117.1 1148148 R 561276 CDS YP_002511118.1 221231966 7327428 complement(1149090..1149611) 1 NC_011900.1 regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity; bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase 1149611 pyrR 7327428 pyrR Streptococcus pneumoniae ATCC 700669 bifunctional pyrimidine regulatory protein PyrR uracil phosphoribosyltransferase YP_002511118.1 1149090 R 561276 CDS YP_002511119.1 221231967 7327438 complement(1149846..1150451) 1 NC_011900.1 endonuclease III 1150451 nth 7327438 nth Streptococcus pneumoniae ATCC 700669 endonuclease III YP_002511119.1 1149846 R 561276 CDS YP_002511120.1 221231968 7328425 complement(1150451..1150993) 1 NC_011900.1 hypothetical protein 1150993 7328425 SPN23F_11740 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511120.1 1150451 R 561276 CDS YP_002511121.1 221231969 7327709 1151727..1152680 1 NC_011900.1 IS1239 transposase 1152680 7327709 SPN23F_11760 Streptococcus pneumoniae ATCC 700669 IS1239 transposase YP_002511121.1 1151727 D 561276 CDS YP_002511122.1 221231970 7327710 1152995..1154521 1 NC_011900.1 ABC transporter ATP-binding protein 1154521 7327710 SPN23F_11770 Streptococcus pneumoniae ATCC 700669 ABC transporter ATP-binding protein YP_002511122.1 1152995 D 561276 CDS YP_002511123.1 221231971 7327711 complement(1154670..1155569) 1 NC_011900.1 metalloprotease; heat shock protein HtpX 1155569 htpX 7327711 htpX Streptococcus pneumoniae ATCC 700669 heat shock protein HtpX YP_002511123.1 1154670 R 561276 CDS YP_002511124.1 221231972 7328077 complement(1155571..1156131) 1 NC_011900.1 LemA family protein 1156131 7328077 SPN23F_11790 Streptococcus pneumoniae ATCC 700669 LemA family protein YP_002511124.1 1155571 R 561276 CDS YP_002511125.1 221231973 7327712 1156225..1156938 1 NC_011900.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 1156938 gidB 7327712 gidB Streptococcus pneumoniae ATCC 700669 16S rRNA methyltransferase GidB YP_002511125.1 1156225 D 561276 CDS YP_002511126.1 221231974 7328593 1157290..1158573 1 NC_011900.1 uracil permease 1158573 pyrP 7328593 pyrP Streptococcus pneumoniae ATCC 700669 uracil permease YP_002511126.1 1157290 D 561276 CDS YP_002511127.1 221231975 7327437 complement(1158768..1160339) 1 NC_011900.1 signal recognition particle protein 1160339 ffh 7327437 ffh Streptococcus pneumoniae ATCC 700669 signal recognition particle protein YP_002511127.1 1158768 R 561276 CDS YP_002511128.1 221231976 7328553 complement(1160351..1160683) 1 NC_011900.1 DNA-binding protein 1160683 7328553 SPN23F_11830 Streptococcus pneumoniae ATCC 700669 DNA-binding protein YP_002511128.1 1160351 R 561276 CDS YP_002511129.1 221231977 7327713 complement(1160774..1161151) 1 NC_011900.1 hypothetical protein 1161151 7327713 SPN23F_11840 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511129.1 1160774 R 561276 CDS YP_002511130.1 221231978 7327714 1161223..1162527 1 NC_011900.1 phosphohydrolase 1162527 7327714 SPN23F_11850 Streptococcus pneumoniae ATCC 700669 phosphohydrolase YP_002511130.1 1161223 D 561276 CDS YP_002511131.1 221231979 7327715 1162540..1163346 1 NC_011900.1 haloacid dehalogenase-like hydrolase 1163346 7327715 SPN23F_11860 Streptococcus pneumoniae ATCC 700669 haloacid dehalogenase-like hydrolase YP_002511131.1 1162540 D 561276 CDS YP_002511132.1 221231980 7327592 complement(1163514..1163861) 1 NC_011900.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 1163861 rplS 7327592 rplS Streptococcus pneumoniae ATCC 700669 50S ribosomal protein L19 YP_002511132.1 1163514 R 561276 CDS YP_002511133.1 221231981 7327486 complement(1163980..1164309) 1 NC_011900.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 1164309 7327486 SPN23F_11880 Streptococcus pneumoniae ATCC 700669 camphor resistance protein CrcB YP_002511133.1 1163980 R 561276 CDS YP_002511134.1 221231982 7327717 complement(1164303..1164677) 1 NC_011900.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 1164677 7327717 SPN23F_11890 Streptococcus pneumoniae ATCC 700669 camphor resistance protein CrcB YP_002511134.1 1164303 R 561276 CDS YP_002511135.1 221231983 7327718 complement(1164674..1164940) 1 NC_011900.1 hypothetical protein 1164940 7327718 SPN23F_11900 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511135.1 1164674 R 561276 CDS YP_002511136.1 221231984 7327719 complement(1165056..1165499) 1 NC_011900.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin 1165499 7327719 SPN23F_11910 Streptococcus pneumoniae ATCC 700669 flavodoxin YP_002511136.1 1165056 R 561276 CDS YP_002511137.1 221231985 7327720 1165603..1166538 1 NC_011900.1 hypothetical protein 1166538 7327720 SPN23F_11920 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511137.1 1165603 D 561276 CDS YP_002511138.1 221231986 7327721 1166634..1166876 1 NC_011900.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 type B 1166876 rpmE2 7327721 rpmE2 Streptococcus pneumoniae ATCC 700669 50S ribosomal protein L31 type B YP_002511138.1 1166634 D 561276 CDS YP_002511139.1 221231987 7327723 1168236..1169582 1 NC_011900.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; glutamate dehydrogenase 1169582 gdh 7327723 gdh Streptococcus pneumoniae ATCC 700669 glutamate dehydrogenase YP_002511139.1 1168236 D 561276 CDS YP_002511140.1 221231988 7327725 complement(1171762..1171920) 1 NC_011900.1 hypothetical protein 1171920 7327725 SPN23F_12010 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511140.1 1171762 R 561276 CDS YP_002511141.1 221231989 7327730 complement(1173713..1173898) 1 NC_011900.1 IS66 transposase Orf1 1173898 7327730 SPN23F_12060 Streptococcus pneumoniae ATCC 700669 IS66 transposase Orf1 YP_002511141.1 1173713 R 561276 CDS YP_002511142.1 221231990 7327731 complement(1174171..1174782) 1 NC_011900.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the D subunit is part of the catalytic core of the ATP synthase complex; V-type ATP synthase subunit D 1174782 ntpD 7327731 ntpD Streptococcus pneumoniae ATCC 700669 V-type ATP synthase subunit D YP_002511142.1 1174171 R 561276 CDS YP_002511143.1 221231991 7328429 complement(1174805..1176190) 1 NC_011900.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the B subunit is part of the catalytic core of the ATP synthase complex; V-type ATP synthase subunit B 1176190 ntpB 7328429 ntpB Streptococcus pneumoniae ATCC 700669 V-type ATP synthase subunit B YP_002511143.1 1174805 R 561276 CDS YP_002511144.1 221231992 7328427 complement(1176191..1177966) 1 NC_011900.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the A subunit is part of the catalytic core of the ATP synthase complex; V-type ATP synthase subunit A 1177966 ntpA 7328427 ntpA Streptococcus pneumoniae ATCC 700669 V-type ATP synthase subunit A YP_002511144.1 1176191 R 561276 CDS YP_002511145.1 221231993 7328426 complement(1178029..1178349) 1 NC_011900.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the F subunit is part of the catalytic core of the ATP synthase complex; V-type ATP synthase subunit F 1178349 7328426 SPN23F_12100 Streptococcus pneumoniae ATCC 700669 V-type ATP synthase subunit F YP_002511145.1 1178029 R 561276 CDS YP_002511146.1 221231994 7327732 complement(1178339..1179346) 1 NC_011900.1 V-type sodium ATP synthase subunit C 1179346 ntpC 7327732 ntpC Streptococcus pneumoniae ATCC 700669 V-type sodium ATP synthase subunit C YP_002511146.1 1178339 R 561276 CDS YP_002511147.1 221231995 7328428 complement(1179411..1179992) 1 NC_011900.1 V-type sodium ATP synthase subunit E 1179992 ntpE 7328428 ntpE Streptococcus pneumoniae ATCC 700669 V-type sodium ATP synthase subunit E YP_002511147.1 1179411 R 561276 CDS YP_002511148.1 221231996 7328430 complement(1180026..1180502) 1 NC_011900.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the K subunit is a nonenzymatic component which binds the dimeric form by interacting with the G and E subunits; V-type ATP synthase subunit K 1180502 ntpK 7328430 ntpK Streptococcus pneumoniae ATCC 700669 V-type ATP synthase subunit K YP_002511148.1 1180026 R 561276 CDS YP_002511149.1 221231997 7328432 complement(1180518..1182509) 1 NC_011900.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I is part of the membrane proton channel.; V-type ATP synthase subunit I 1182509 ntpI 7328432 ntpI Streptococcus pneumoniae ATCC 700669 V-type ATP synthase subunit I YP_002511149.1 1180518 R 561276 CDS YP_002511150.1 221231998 7328431 complement(1182499..1182822) 1 NC_011900.1 hypothetical protein 1182822 7328431 SPN23F_12150 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511150.1 1182499 R 561276 CDS YP_002511151.1 221231999 7327733 complement(1182847..1183737) 1 NC_011900.1 ROK family protein 1183737 7327733 SPN23F_12160 Streptococcus pneumoniae ATCC 700669 ROK family protein YP_002511151.1 1182847 R 561276 CDS YP_002511152.1 221232000 7327734 complement(1183894..1185003) 1 NC_011900.1 oxidoreductase 1185003 7327734 SPN23F_12170 Streptococcus pneumoniae ATCC 700669 oxidoreductase YP_002511152.1 1183894 R 561276 CDS YP_002511153.1 221232001 7327735 complement(1185043..1187265) 1 NC_011900.1 sialidase (neuraminidase) 1187265 7327735 SPN23F_12180 Streptococcus pneumoniae ATCC 700669 sialidase (neuraminidase) YP_002511153.1 1185043 R 561276 CDS YP_002511154.1 221232002 7327736 complement(1187267..1187725) 1 NC_011900.1 hypothetical protein 1187725 7327736 SPN23F_12190 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511154.1 1187267 R 561276 CDS YP_002511155.1 221232003 7327737 complement(1187751..1189292) 1 NC_011900.1 sodium:solute symporter 1189292 7327737 SPN23F_12200 Streptococcus pneumoniae ATCC 700669 sodium:solute symporter YP_002511155.1 1187751 R 561276 CDS YP_002511156.1 221232004 7327738 complement(1189320..1190237) 1 NC_011900.1 N-acetylneuraminate lyase 1190237 nanA 7327738 nanA Streptococcus pneumoniae ATCC 700669 N-acetylneuraminate lyase YP_002511156.1 1189320 R 561276 CDS YP_002511157.1 221232005 7328414 complement(1190262..1190951) 1 NC_011900.1 N-acetylmannosamine-6-phosphate 2-epimerase 1190951 nanE 7328414 nanE Streptococcus pneumoniae ATCC 700669 N-acetylmannosamine-6-phosphate 2-epimerase YP_002511157.1 1190262 R 561276 CDS YP_002511158.1 221232006 7328417 1191723..1192979 1 NC_011900.1 IS1167 transposase 1192979 7328417 SPN23F_12230 Streptococcus pneumoniae ATCC 700669 IS1167 transposase YP_002511158.1 1191723 D 561276 CDS YP_002511159.1 221232007 7327739 complement(1193090..1193701) 1 NC_011900.1 phosphosugar-binding transcriptional regulator 1193701 7327739 SPN23F_12240 Streptococcus pneumoniae ATCC 700669 phosphosugar-binding transcriptional regulator YP_002511159.1 1193090 R 561276 CDS YP_002511160.1 221232008 7328301 1194026..1194634 1 NC_011900.1 hypothetical protein 1194634 7328301 SPN23F_12250 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511160.1 1194026 D 561276 CDS YP_002511161.1 221232009 7329594 complement(1194869..1195708) 1 NC_011900.1 IS861 transposase Orf2 1195708 7329594 SPN23F_12260 Streptococcus pneumoniae ATCC 700669 IS861 transposase Orf2 YP_002511161.1 1194869 R 561276 CDS YP_002511162.1 221232010 7329595 complement(1195684..1196220) 1 NC_011900.1 IS861 transposase Orf1 1196220 7329595 SPN23F_12270 Streptococcus pneumoniae ATCC 700669 IS861 transposase Orf1 YP_002511162.1 1195684 R 561276 CDS YP_002511163.1 221232011 7329596 complement(1196516..1196653) 1 NC_011900.1 hypothetical protein 1196653 7329596 SPN23F_12280 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511163.1 1196516 R 561276 CDS YP_002511164.1 221232012 7329597 complement(1196787..1198106) 1 NC_011900.1 hypothetical protein 1198106 7329597 SPN23F_12290 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511164.1 1196787 R 561276 CDS YP_002511165.1 221232013 7329598 complement(1198109..1198849) 1 NC_011900.1 ABC transporter ATP-binding protein 1198849 7329598 SPN23F_12300 Streptococcus pneumoniae ATCC 700669 ABC transporter ATP-binding protein YP_002511165.1 1198109 R 561276 CDS YP_002511166.1 221232014 7329599 complement(1198864..1200471) 1 NC_011900.1 ABC transporter ATP-binding protein 1200471 7329599 SPN23F_12310 Streptococcus pneumoniae ATCC 700669 ABC transporter ATP-binding protein YP_002511166.1 1198864 R 561276 CDS YP_002511167.1 221232015 7329600 complement(1200468..1202408) 1 NC_011900.1 protease II (oligopeptidase B) 1202408 ptrB 7329600 ptrB Streptococcus pneumoniae ATCC 700669 protease II (oligopeptidase B) YP_002511167.1 1200468 R 561276 CDS YP_002511168.1 221232016 7327892 complement(1202441..1205050) 1 NC_011900.1 lantibiotic synthetase 1205050 7327892 SPN23F_12330 Streptococcus pneumoniae ATCC 700669 lantibiotic synthetase YP_002511168.1 1202441 R 561276 CDS YP_002511169.1 221232017 7329601 complement(1205229..1205366) 1 NC_011900.1 hypothetical protein 1205366 7329601 SPN23F_12340 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511169.1 1205229 R 561276 CDS YP_002511170.1 221232018 7329602 complement(1205568..1206155) 1 NC_011900.1 hypothetical protein 1206155 7329602 SPN23F_12350 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511170.1 1205568 R 561276 CDS YP_002511171.1 221232019 7329604 complement(1206404..1206784) 1 NC_011900.1 hypothetical protein 1206784 7329604 SPN23F_12370 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511171.1 1206404 R 561276 CDS YP_002511172.1 221232020 7329605 complement(1206777..1207100) 1 NC_011900.1 hypothetical protein 1207100 7329605 SPN23F_12380 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511172.1 1206777 R 561276 CDS YP_002511173.1 221232021 7329606 complement(1207108..1207362) 1 NC_011900.1 replication initiator protein 1207362 7329606 SPN23F_12390 Streptococcus pneumoniae ATCC 700669 replication initiator protein YP_002511173.1 1207108 R 561276 CDS YP_002511174.1 221232022 7329607 complement(1207362..1207532) 1 NC_011900.1 hypothetical protein 1207532 7329607 SPN23F_12400 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511174.1 1207362 R 561276 CDS YP_002511175.1 221232023 7329608 complement(1207785..1208972) 1 NC_011900.1 integrase 1208972 7329608 SPN23F_12410 Streptococcus pneumoniae ATCC 700669 integrase YP_002511175.1 1207785 R 561276 CDS YP_002511176.1 221232024 7329609 complement(1208944..1209213) 1 NC_011900.1 hypothetical protein 1209213 7329609 SPN23F_12420 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511176.1 1208944 R 561276 CDS YP_002511177.1 221232025 7329610 complement(1209814..1211643) 1 NC_011900.1 relaxase 1211643 7329610 SPN23F_12430 Streptococcus pneumoniae ATCC 700669 relaxase YP_002511177.1 1209814 R 561276 CDS YP_002511178.1 221232026 7329611 complement(1211630..1211995) 1 NC_011900.1 mobilisation protein 1211995 7329611 SPN23F_12440 Streptococcus pneumoniae ATCC 700669 mobilisation protein YP_002511178.1 1211630 R 561276 CDS YP_002511179.1 221232027 7329612 complement(1212000..1212356) 1 NC_011900.1 mobilisation protein 1212356 7329612 SPN23F_12450 Streptococcus pneumoniae ATCC 700669 mobilisation protein YP_002511179.1 1212000 R 561276 CDS YP_002511180.1 221232028 7329613 complement(1212740..1212994) 1 NC_011900.1 hypothetical protein 1212994 7329613 SPN23F_12460 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511180.1 1212740 R 561276 CDS YP_002511181.1 221232029 7329614 complement(1213060..1217064) 1 NC_011900.1 DNA helicase II, UvrD 1217064 7329614 SPN23F_12470 Streptococcus pneumoniae ATCC 700669 DNA helicase II, UvrD YP_002511181.1 1213060 R 561276 CDS YP_002511182.1 221232030 7329615 complement(1217186..1217572) 1 NC_011900.1 hypothetical protein 1217572 7329615 SPN23F_12480 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511182.1 1217186 R 561276 CDS YP_002511183.1 221232031 7329616 complement(1217644..1218594) 1 NC_011900.1 hypothetical protein 1218594 7329616 SPN23F_12490 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511183.1 1217644 R 561276 CDS YP_002511184.1 221232032 7329617 complement(1218679..1219797) 1 NC_011900.1 hypothetical protein 1219797 7329617 SPN23F_12500 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511184.1 1218679 R 561276 CDS YP_002511185.1 221232033 7329618 complement(1220059..1221855) 1 NC_011900.1 NTPase protein 1221855 7329618 SPN23F_12510 Streptococcus pneumoniae ATCC 700669 NTPase protein YP_002511185.1 1220059 R 561276 CDS YP_002511186.1 221232034 7329619 complement(1222272..1222538) 1 NC_011900.1 hypothetical protein 1222538 7329619 SPN23F_12520 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511186.1 1222272 R 561276 CDS YP_002511187.1 221232035 7329620 complement(1222525..1223229) 1 NC_011900.1 phosphoserine phosphatase 1223229 7329620 SPN23F_12530 Streptococcus pneumoniae ATCC 700669 phosphoserine phosphatase YP_002511187.1 1222525 R 561276 CDS YP_002511188.1 221232036 7329621 complement(1223282..1223848) 1 NC_011900.1 hypothetical protein 1223848 7329621 SPN23F_12540 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511188.1 1223282 R 561276 CDS YP_002511189.1 221232037 7329622 complement(1223941..1224165) 1 NC_011900.1 hypothetical protein 1224165 7329622 SPN23F_12550 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511189.1 1223941 R 561276 CDS YP_002511190.1 221232038 7329623 complement(1224254..1224871) 1 NC_011900.1 hypothetical protein 1224871 7329623 SPN23F_12560 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511190.1 1224254 R 561276 CDS YP_002511191.1 221232039 7329624 complement(1225193..1225915) 1 NC_011900.1 hypothetical protein 1225915 7329624 SPN23F_12570 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511191.1 1225193 R 561276 CDS YP_002511192.1 221232040 7329625 1226244..1227167 1 NC_011900.1 replication protein 1227167 rep 7329625 rep Streptococcus pneumoniae ATCC 700669 replication protein YP_002511192.1 1226244 D 561276 CDS YP_002511193.1 221232041 7327450 complement(1228032..1228682) 1 NC_011900.1 chloramphenicol acetyltransferase 1228682 7327450 SPN23F_12590 Streptococcus pneumoniae ATCC 700669 chloramphenicol acetyltransferase YP_002511193.1 1228032 R 561276 CDS YP_002511194.1 221232042 7329626 complement(1228853..1229101) 1 NC_011900.1 hypothetical protein 1229101 7329626 SPN23F_12600 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511194.1 1228853 R 561276 CDS YP_002511195.1 221232043 7329627 complement(1229340..1230128) 1 NC_011900.1 hypothetical protein 1230128 7329627 SPN23F_12610 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511195.1 1229340 R 561276 CDS YP_002511196.1 221232044 7329628 complement(1230604..1231362) 1 NC_011900.1 zeta toxin 1231362 7329628 SPN23F_12620 Streptococcus pneumoniae ATCC 700669 zeta toxin YP_002511196.1 1230604 R 561276 CDS YP_002511197.1 221232045 7329629 complement(1231362..1231838) 1 NC_011900.1 epsilon antitoxin 1231838 7329629 SPN23F_12630 Streptococcus pneumoniae ATCC 700669 epsilon antitoxin YP_002511197.1 1231362 R 561276 CDS YP_002511198.1 221232046 7329630 complement(1231908..1232180) 1 NC_011900.1 hypothetical protein 1232180 7329630 SPN23F_12640 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511198.1 1231908 R 561276 CDS YP_002511199.1 221232047 7329631 complement(1232218..1232601) 1 NC_011900.1 hypothetical protein 1232601 7329631 SPN23F_12650 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511199.1 1232218 R 561276 CDS YP_002511200.1 221232048 7329632 complement(1232598..1232831) 1 NC_011900.1 hypothetical protein 1232831 7329632 SPN23F_12660 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511200.1 1232598 R 561276 CDS YP_002511201.1 221232049 7329633 complement(1232882..1233967) 1 NC_011900.1 hypothetical protein 1233967 7329633 SPN23F_12670 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511201.1 1232882 R 561276 CDS YP_002511202.1 221232050 7329634 complement(1233977..1234618) 1 NC_011900.1 hypothetical protein 1234618 7329634 SPN23F_12680 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511202.1 1233977 R 561276 CDS YP_002511203.1 221232051 7329635 complement(1234839..1236962) 1 NC_011900.1 lantibiotic transport/processing ATP-binding protein 1236962 7329635 SPN23F_12690 Streptococcus pneumoniae ATCC 700669 lantibiotic transport/processing ATP-binding protein YP_002511203.1 1234839 R 561276 CDS YP_002511204.1 221232052 7329636 complement(1236969..1240220) 1 NC_011900.1 lantibiotic synthetase 1240220 7329636 SPN23F_12700 Streptococcus pneumoniae ATCC 700669 lantibiotic synthetase YP_002511204.1 1236969 R 561276 CDS YP_002511205.1 221232053 7329637 complement(1240303..1240518) 1 NC_011900.1 lantibiotic precursor 1240518 7329637 SPN23F_12701 Streptococcus pneumoniae ATCC 700669 lantibiotic precursor YP_002511205.1 1240303 R 561276 CDS YP_002511206.1 221232054 7329638 complement(1240663..1241343) 1 NC_011900.1 lantibiotic ABC transporter 1241343 7329638 SPN23F_12710 Streptococcus pneumoniae ATCC 700669 lantibiotic ABC transporter YP_002511206.1 1240663 R 561276 CDS YP_002511207.1 221232055 7329639 complement(1241392..1242132) 1 NC_011900.1 lantibiotic ABC transporter 1242132 7329639 SPN23F_12720 Streptococcus pneumoniae ATCC 700669 lantibiotic ABC transporter YP_002511207.1 1241392 R 561276 CDS YP_002511208.1 221232056 7329640 complement(1242125..1243060) 1 NC_011900.1 lantibiotic ABC transporter ATP-binding protein 1243060 7329640 SPN23F_12730 Streptococcus pneumoniae ATCC 700669 lantibiotic ABC transporter ATP-binding protein YP_002511208.1 1242125 R 561276 CDS YP_002511209.1 221232057 7329641 complement(1243238..1243411) 1 NC_011900.1 hypothetical protein 1243411 7329641 SPN23F_12740 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511209.1 1243238 R 561276 CDS YP_002511210.1 221232058 7329642 1243602..1244462 1 NC_011900.1 transcriptional regulator 1244462 7329642 SPN23F_12750 Streptococcus pneumoniae ATCC 700669 transcriptional regulator YP_002511210.1 1243602 D 561276 CDS YP_002511211.1 221232059 7329643 complement(1244545..1244835) 1 NC_011900.1 hypothetical protein 1244835 7329643 SPN23F_12760 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511211.1 1244545 R 561276 CDS YP_002511212.1 221232060 7329644 complement(1244849..1245133) 1 NC_011900.1 hypothetical protein 1245133 7329644 SPN23F_12770 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511212.1 1244849 R 561276 CDS YP_002511214.1 221232061 7329645 complement(1246260..1248071) 1 NC_011900.1 group II intron reverse transcriptase/maturase 1248071 7329645 SPN23F_12790 Streptococcus pneumoniae ATCC 700669 group II intron reverse transcriptase/maturase YP_002511214.1 1246260 R 561276 CDS YP_002511215.1 221232062 7329648 complement(1254542..1255108) 1 NC_011900.1 hypothetical protein 1255108 7329648 SPN23F_12830 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511215.1 1254542 R 561276 CDS YP_002511216.1 221232063 7329649 complement(1255346..1258159) 1 NC_011900.1 Possible involvement with cell wall metabolism; conjugal transfer protein 1258159 7329649 SPN23F_12840 Streptococcus pneumoniae ATCC 700669 conjugal transfer protein YP_002511216.1 1255346 R 561276 CDS YP_002511217.1 221232064 7329650 complement(1258171..1260486) 1 NC_011900.1 conjugal transfer protein 1260486 7329650 SPN23F_12850 Streptococcus pneumoniae ATCC 700669 conjugal transfer protein YP_002511217.1 1258171 R 561276 CDS YP_002511218.1 221232065 7329651 complement(1260476..1260838) 1 NC_011900.1 hypothetical protein 1260838 7329651 SPN23F_12860 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511218.1 1260476 R 561276 CDS YP_002511219.1 221232066 7329652 complement(1260892..1261746) 1 NC_011900.1 hypothetical protein 1261746 7329652 SPN23F_12870 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511219.1 1260892 R 561276 CDS YP_002511220.1 221232067 7329653 complement(1261763..1262005) 1 NC_011900.1 hypothetical protein 1262005 7329653 SPN23F_12880 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511220.1 1261763 R 561276 CDS YP_002511221.1 221232068 7329654 complement(1262026..1263906) 1 NC_011900.1 conjugal transfer protein TraG 1263906 traG 7329654 traG Streptococcus pneumoniae ATCC 700669 conjugal transfer protein TraG YP_002511221.1 1262026 R 561276 CDS YP_002511222.1 221232069 7327581 complement(1263903..1264391) 1 NC_011900.1 hypothetical protein 1264391 7327581 SPN23F_12900 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511222.1 1263903 R 561276 CDS YP_002511223.1 221232070 7329655 complement(1264381..1264680) 1 NC_011900.1 hypothetical protein 1264680 7329655 SPN23F_12910 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511223.1 1264381 R 561276 CDS YP_002511224.1 221232071 7329656 complement(1264963..1265799) 1 NC_011900.1 hypothetical protein 1265799 7329656 SPN23F_12920 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511224.1 1264963 R 561276 CDS YP_002511225.1 221232072 7329657 complement(1265799..1266389) 1 NC_011900.1 hypothetical protein 1266389 7329657 SPN23F_12930 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511225.1 1265799 R 561276 CDS YP_002511226.1 221232073 7329658 1266820..1267134 1 NC_011900.1 conjugative transposon protein 1267134 orf23 7329658 orf23 Streptococcus pneumoniae ATCC 700669 conjugative transposon protein YP_002511226.1 1266820 D 561276 CDS YP_002511227.1 221232074 7328447 1267153..1267536 1 NC_011900.1 conjugative transposon protein 1267536 orf22 7328447 orf22 Streptococcus pneumoniae ATCC 700669 conjugative transposon protein YP_002511227.1 1267153 D 561276 CDS YP_002511228.1 221232075 7328446 1267565..1268950 1 NC_011900.1 conjugative transposon FtsK/SpoIIIE-family protein 1268950 orf21 7328446 orf21 Streptococcus pneumoniae ATCC 700669 conjugative transposon FtsK/SpoIIIE-family protein YP_002511228.1 1267565 D 561276 CDS YP_002511229.1 221232076 7328445 1269128..1270333 1 NC_011900.1 conjugative transposon replication initiation factor 1270333 orf20 7328445 orf20 Streptococcus pneumoniae ATCC 700669 conjugative transposon replication initiation factor YP_002511229.1 1269128 D 561276 CDS YP_002511230.1 221232077 7328444 1270376..1270597 1 NC_011900.1 conjugative transposon protein 1270597 orf19 7328444 orf19 Streptococcus pneumoniae ATCC 700669 conjugative transposon protein YP_002511230.1 1270376 D 561276 CDS YP_002511231.1 221232078 7328443 1270714..1271211 1 NC_011900.1 conjugative transposon protein 1271211 orf18 7328443 orf18 Streptococcus pneumoniae ATCC 700669 conjugative transposon protein YP_002511231.1 1270714 D 561276 CDS YP_002511232.1 221232079 7328442 1271462..1271692 1 NC_011900.1 conjugative transposon membrane protein 1271692 orf17 7328442 orf17 Streptococcus pneumoniae ATCC 700669 conjugative transposon membrane protein YP_002511232.1 1271462 D 561276 CDS YP_002511233.1 221232080 7328441 1271676..1274123 1 NC_011900.1 conjugative transposon ATP/GTP-binding protein 1274123 orf16 7328441 orf16 Streptococcus pneumoniae ATCC 700669 conjugative transposon ATP/GTP-binding protein YP_002511233.1 1271676 D 561276 CDS YP_002511234.1 221232081 7328440 1274126..1276276 1 NC_011900.1 conjugative transposon membrane protein 1276276 orf15 7328440 orf15 Streptococcus pneumoniae ATCC 700669 conjugative transposon membrane protein YP_002511234.1 1274126 D 561276 CDS YP_002511235.1 221232082 7328439 1276295..1277296 1 NC_011900.1 cell wall hydrolase 1277296 orf14 7328439 orf14 Streptococcus pneumoniae ATCC 700669 cell wall hydrolase YP_002511235.1 1276295 D 561276 CDS YP_002511236.1 221232083 7328438 1277311..1278225 1 NC_011900.1 conjugative transposon exported protein 1278225 orf13 7328438 orf13 Streptococcus pneumoniae ATCC 700669 conjugative transposon exported protein YP_002511236.1 1277311 D 561276 CDS YP_002511237.1 221232084 7328437 1278602..1280521 1 NC_011900.1 conjugative transposon tetracycline resistance protein 1280521 tetM 7328437 tetM Streptococcus pneumoniae ATCC 700669 conjugative transposon tetracycline resistance protein YP_002511237.1 1278602 D 561276 CDS YP_002511238.1 221232085 7329164 complement(1280867..1281220) 1 NC_011900.1 conjugative transposon regulatory protein 1281220 orf9 7329164 orf9 Streptococcus pneumoniae ATCC 700669 conjugative transposon regulatory protein YP_002511238.1 1280867 R 561276 CDS YP_002511239.1 221232086 7328449 1281350..1281496 1 NC_011900.1 hypothetical protein 1281496 7328449 SPN23F_13061 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511239.1 1281350 D 561276 CDS YP_002511240.1 221232087 7329659 1281725..1282147 1 NC_011900.1 conjugative transposon regulatory protein 1282147 orf7 7329659 orf7 Streptococcus pneumoniae ATCC 700669 conjugative transposon regulatory protein YP_002511240.1 1281725 D 561276 CDS YP_002511241.1 221232088 7328448 1282835..1283038 1 NC_011900.1 excisionase 1283038 xis 7328448 xis Streptococcus pneumoniae ATCC 700669 excisionase YP_002511241.1 1282835 D 561276 CDS YP_002511242.1 221232089 7329661 complement(1284551..1285138) 1 NC_011900.1 CAAX amino terminal protease 1285138 7329661 SPN23F_13110 Streptococcus pneumoniae ATCC 700669 CAAX amino terminal protease YP_002511242.1 1284551 R 561276 CDS YP_002511243.1 221232090 7329662 complement(1285141..1285374) 1 NC_011900.1 hypothetical protein 1285374 7329662 SPN23F_13120 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511243.1 1285141 R 561276 CDS YP_002511244.1 221232091 7329663 complement(1285387..1285767) 1 NC_011900.1 hypothetical protein 1285767 7329663 SPN23F_13130 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511244.1 1285387 R 561276 CDS YP_002511245.1 221232092 7329664 complement(1285760..1286209) 1 NC_011900.1 hypothetical protein 1286209 7329664 SPN23F_13140 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511245.1 1285760 R 561276 CDS YP_002511246.1 221232093 7329665 complement(1286193..1287551) 1 NC_011900.1 DNA methylase 1287551 7329665 SPN23F_13150 Streptococcus pneumoniae ATCC 700669 DNA methylase YP_002511246.1 1286193 R 561276 CDS YP_002511247.1 221232094 7329666 complement(1287650..1288429) 1 NC_011900.1 replication initiator protein 1288429 7329666 SPN23F_13160 Streptococcus pneumoniae ATCC 700669 replication initiator protein YP_002511247.1 1287650 R 561276 CDS YP_002511248.1 221232095 7329667 complement(1288426..1288599) 1 NC_011900.1 hypothetical protein 1288599 7329667 SPN23F_13170 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511248.1 1288426 R 561276 CDS YP_002511249.1 221232096 7329668 complement(1288801..1289169) 1 NC_011900.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 1289169 rplL 7329668 rplL Streptococcus pneumoniae ATCC 700669 50S ribosomal protein L7/L12 YP_002511249.1 1288801 R 561276 CDS YP_002511250.1 221232097 7327479 complement(1289245..1289745) 1 NC_011900.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 1289745 rplJ 7327479 rplJ Streptococcus pneumoniae ATCC 700669 50S ribosomal protein L10 YP_002511250.1 1289245 R 561276 CDS YP_002511251.1 221232098 7327477 complement(1289995..1291254) 1 NC_011900.1 chlorohydrolase 1291254 7327477 SPN23F_13210 Streptococcus pneumoniae ATCC 700669 chlorohydrolase YP_002511251.1 1289995 R 561276 CDS YP_002511252.1 221232099 7329669 complement(1291601..1293349) 1 NC_011900.1 ABC transporter ATP-binding protein 1293349 7329669 SPN23F_13220 Streptococcus pneumoniae ATCC 700669 ABC transporter ATP-binding protein YP_002511252.1 1291601 R 561276 CDS YP_002511253.1 221232100 7329670 complement(1293351..1295075) 1 NC_011900.1 ABC transporter ATP-binding protein 1295075 7329670 SPN23F_13230 Streptococcus pneumoniae ATCC 700669 ABC transporter ATP-binding protein YP_002511253.1 1293351 R 561276 CDS YP_002511254.1 221232101 7329671 complement(1295133..1296071) 1 NC_011900.1 peptide methionine sulfoxide reductase 1296071 msrAB 7329671 msrAB Streptococcus pneumoniae ATCC 700669 peptide methionine sulfoxide reductase YP_002511254.1 1295133 R 561276 CDS YP_002511255.1 221232102 7327819 complement(1296321..1297190) 1 NC_011900.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase 1297190 thrB 7327819 thrB Streptococcus pneumoniae ATCC 700669 homoserine kinase YP_002511255.1 1296321 R 561276 CDS YP_002511256.1 221232103 7329173 complement(1297192..1298478) 1 NC_011900.1 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine; homoserine dehydrogenase 1298478 hom 7329173 hom Streptococcus pneumoniae ATCC 700669 homoserine dehydrogenase YP_002511256.1 1297192 R 561276 CDS YP_002511257.1 221232104 7328074 complement(1298629..1299366) 1 NC_011900.1 enables recognition and targeting of proteins for proteolysis, involved in negative regulation of competence; adaptor protein 1299366 mecA 7328074 mecA Streptococcus pneumoniae ATCC 700669 adaptor protein YP_002511257.1 1298629 R 561276 CDS YP_002511258.1 221232105 7328124 complement(1299566..1300600) 1 NC_011900.1 hypothetical protein 1300600 7328124 SPN23F_13290 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511258.1 1299566 R 561276 CDS YP_002511259.1 221232106 7329672 complement(1300629..1302062) 1 NC_011900.1 Hydrophobicity plot and neighbouring genes suggest this may be a polysaccharide polymerase.; hypothetical protein 1302062 7329672 SPN23F_13300 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511259.1 1300629 R 561276 CDS YP_002511260.1 221232107 7328541 complement(1302078..1303064) 1 NC_011900.1 glycosyl transferase 1303064 7328541 SPN23F_13310 Streptococcus pneumoniae ATCC 700669 glycosyl transferase YP_002511260.1 1302078 R 561276 CDS YP_002511261.1 221232108 7329260 complement(1303066..1304166) 1 NC_011900.1 glycosyl transferase 1304166 7329260 SPN23F_13320 Streptococcus pneumoniae ATCC 700669 glycosyl transferase YP_002511261.1 1303066 R 561276 CDS YP_002511262.1 221232109 7329261 complement(1304159..1305004) 1 NC_011900.1 LicD-family phosphotransferase 1305004 7329261 SPN23F_13330 Streptococcus pneumoniae ATCC 700669 LicD-family phosphotransferase YP_002511262.1 1304159 R 561276 CDS YP_002511263.1 221232110 7329262 complement(1305283..1306557) 1 NC_011900.1 Local genes and Pfam suggest that this may be related to cpsA; cell envelope-related transcriptional attenuator domain protein 1306557 7329262 SPN23F_13340 Streptococcus pneumoniae ATCC 700669 cell envelope-related transcriptional attenuator domain protein YP_002511263.1 1305283 R 561276 CDS YP_002511264.1 221232111 7329263 complement(1306554..1307402) 1 NC_011900.1 catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; prephenate dehydratase 1307402 pheA 7329263 pheA Streptococcus pneumoniae ATCC 700669 prephenate dehydratase YP_002511264.1 1306554 R 561276 CDS YP_002511265.1 221232112 7327841 complement(1307399..1307875) 1 NC_011900.1 shikimate kinase 1307875 aroK 7327841 aroK Streptococcus pneumoniae ATCC 700669 shikimate kinase YP_002511265.1 1307399 R 561276 CDS YP_002511266.1 221232113 7328665 complement(1307868..1309151) 1 NC_011900.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase 1309151 aroA 7328665 aroA Streptococcus pneumoniae ATCC 700669 3-phosphoshikimate 1-carboxyvinyltransferase YP_002511266.1 1307868 R 561276 CDS YP_002511267.1 221232114 7328658 complement(1309243..1309581) 1 NC_011900.1 hypothetical protein 1309581 7328658 SPN23F_13380 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511267.1 1309243 R 561276 CDS YP_002511268.1 221232115 7329264 complement(1309592..1310695) 1 NC_011900.1 catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate; prephenate dehydrogenase 1310695 tyrA 7329264 tyrA Streptococcus pneumoniae ATCC 700669 prephenate dehydrogenase YP_002511268.1 1309592 R 561276 CDS YP_002511269.1 221232116 7327657 complement(1310705..1311871) 1 NC_011900.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase 1311871 aroF 7327657 aroF Streptococcus pneumoniae ATCC 700669 chorismate synthase YP_002511269.1 1310705 R 561276 CDS YP_002511270.1 221232117 7328662 complement(1311881..1312948) 1 NC_011900.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 1312948 aroB 7328662 aroB Streptococcus pneumoniae ATCC 700669 3-dehydroquinate synthase YP_002511270.1 1311881 R 561276 CDS YP_002511271.1 221232118 7328659 complement(1312967..1313821) 1 NC_011900.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase 1313821 aroE 7328659 aroE Streptococcus pneumoniae ATCC 700669 shikimate 5-dehydrogenase YP_002511271.1 1312967 R 561276 CDS YP_002511272.1 221232119 7328661 complement(1313811..1314488) 1 NC_011900.1 catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis; 3-dehydroquinate dehydratase 1314488 aroD 7328661 aroD Streptococcus pneumoniae ATCC 700669 3-dehydroquinate dehydratase YP_002511272.1 1313811 R 561276 CDS YP_002511273.1 221232120 7328660 complement(1314485..1315657) 1 NC_011900.1 hypothetical protein 1315657 7328660 SPN23F_13440 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511273.1 1314485 R 561276 CDS YP_002511274.1 221232121 7329265 complement(1316333..1317967) 1 NC_011900.1 hypothetical protein 1317967 7329265 SPN23F_13450 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511274.1 1316333 R 561276 CDS YP_002511275.1 221232122 7329266 complement(1317948..1318697) 1 NC_011900.1 ABC transporter ATP-binding protein 1318697 7329266 SPN23F_13460 Streptococcus pneumoniae ATCC 700669 ABC transporter ATP-binding protein YP_002511275.1 1317948 R 561276 CDS YP_002511276.1 221232123 7329267 1318876..1320330 1 NC_011900.1 converts 1,4-alpha-D-glucans to maltodextrin; cytoplasmic alpha-amylase 1320330 7329267 SPN23F_13470 Streptococcus pneumoniae ATCC 700669 cytoplasmic alpha-amylase YP_002511276.1 1318876 D 561276 CDS YP_002511277.1 221232124 7329268 complement(1320420..1323038) 1 NC_011900.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 1323038 alaS 7329268 alaS Streptococcus pneumoniae ATCC 700669 alanyl-tRNA synthetase YP_002511277.1 1320420 R 561276 CDS YP_002511278.1 221232125 7328644 complement(1323060..1323545) 1 NC_011900.1 hypothetical protein 1323545 7328644 SPN23F_13490 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511278.1 1323060 R 561276 CDS YP_002511279.1 221232126 7329269 complement(1324320..1325390) 1 NC_011900.1 spermidine/putrescine extracellular binding protein 1325390 potD 7329269 potD Streptococcus pneumoniae ATCC 700669 spermidine/putrescine extracellular binding protein YP_002511279.1 1324320 R 561276 CDS YP_002511280.1 221232127 7327868 complement(1325387..1326160) 1 NC_011900.1 spermidine/putrescine ABC transporter permease 1326160 potC 7327868 potC Streptococcus pneumoniae ATCC 700669 spermidine/putrescine ABC transporter permease YP_002511280.1 1325387 R 561276 CDS YP_002511281.1 221232128 7327867 complement(1326157..1326963) 1 NC_011900.1 spermidine/putrescine ABC transporter permease 1326963 potB 7327867 potB Streptococcus pneumoniae ATCC 700669 spermidine/putrescine ABC transporter permease YP_002511281.1 1326157 R 561276 CDS YP_002511282.1 221232129 7327866 complement(1326944..1328101) 1 NC_011900.1 spermidine/putrescine ABC transporter ATP-binding protein 1328101 potA 7327866 potA Streptococcus pneumoniae ATCC 700669 spermidine/putrescine ABC transporter ATP-binding protein YP_002511282.1 1326944 R 561276 CDS YP_002511283.1 221232130 7327865 complement(1328160..1329110) 1 NC_011900.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 1329110 murB 7327865 murB Streptococcus pneumoniae ATCC 700669 UDP-N-acetylenolpyruvoylglucosamine reductase YP_002511283.1 1328160 R 561276 CDS YP_002511284.1 221232131 7328392 complement(1329222..1329974) 1 NC_011900.1 hypothetical protein 1329974 7328392 SPN23F_13550 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511284.1 1329222 R 561276 CDS YP_002511285.1 221232132 7329270 complement(1329984..1330715) 1 NC_011900.1 alpha-acetolactate decarboxylase 1330715 aldB 7329270 aldB Streptococcus pneumoniae ATCC 700669 alpha-acetolactate decarboxylase YP_002511285.1 1329984 R 561276 CDS YP_002511286.1 221232133 7328645 1330857..1332128 1 NC_011900.1 GntR family transcriptional regulator 1332128 7328645 SPN23F_13570 Streptococcus pneumoniae ATCC 700669 GntR family transcriptional regulator YP_002511286.1 1330857 D 561276 CDS YP_002511287.1 221232134 7329271 complement(1332148..1332963) 1 NC_011900.1 extracellular amino acid-binding protein 1332963 7329271 SPN23F_13580 Streptococcus pneumoniae ATCC 700669 extracellular amino acid-binding protein YP_002511287.1 1332148 R 561276 CDS YP_002511288.1 221232135 7329272 complement(1333120..1333773) 1 NC_011900.1 phosphate transport system protein 1333773 phoU 7329272 phoU Streptococcus pneumoniae ATCC 700669 phosphate transport system protein YP_002511288.1 1333120 R 561276 CDS YP_002511289.1 221232136 7327846 complement(1333785..1334543) 1 NC_011900.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein 1334543 pstB1 7327846 pstB1 Streptococcus pneumoniae ATCC 700669 phosphate transporter ATP-binding protein YP_002511289.1 1333785 R 561276 CDS YP_002511290.1 221232137 7327885 complement(1334556..1335359) 1 NC_011900.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein 1335359 pstB2 7327885 pstB2 Streptococcus pneumoniae ATCC 700669 phosphate transporter ATP-binding protein YP_002511290.1 1334556 R 561276 CDS YP_002511291.1 221232138 7327886 complement(1335370..1336254) 1 NC_011900.1 phosphate ABC transporter permease 1336254 7327886 SPN23F_13620 Streptococcus pneumoniae ATCC 700669 phosphate ABC transporter permease YP_002511291.1 1335370 R 561276 CDS YP_002511292.1 221232139 7329273 complement(1336244..1336693) 1 NC_011900.1 phosphate ABC transporter permease 1336693 7329273 SPN23F_13630 Streptococcus pneumoniae ATCC 700669 phosphate ABC transporter permease YP_002511292.1 1336244 R 561276 CDS YP_002511293.1 221232140 7329274 complement(1336745..1337161) 1 NC_011900.1 phosphate ABC transporter permease 1337161 7329274 SPN23F_13640 Streptococcus pneumoniae ATCC 700669 phosphate ABC transporter permease YP_002511293.1 1336745 R 561276 CDS YP_002511294.1 221232141 7329275 complement(1337161..1338039) 1 NC_011900.1 phosphate ABC transporter substrate-binding protein 1338039 pstS 7329275 pstS Streptococcus pneumoniae ATCC 700669 phosphate ABC transporter substrate-binding protein YP_002511294.1 1337161 R 561276 CDS YP_002511295.1 221232142 7327889 complement(1338613..1339917) 1 NC_011900.1 NOL1/NOP2/sun family protein 1339917 7327889 SPN23F_13670 Streptococcus pneumoniae ATCC 700669 NOL1/NOP2/sun family protein YP_002511295.1 1338613 R 561276 CDS YP_002511296.1 221232143 7329276 complement(1339918..1340691) 1 NC_011900.1 myo-inositol-1(or 4)-monophosphatase 1340691 7329276 SPN23F_13680 Streptococcus pneumoniae ATCC 700669 myo-inositol-1(or 4)-monophosphatase YP_002511296.1 1339918 R 561276 CDS YP_002511297.1 221232144 7329277 complement(1340681..1340899) 1 NC_011900.1 hypothetical protein 1340899 7329277 SPN23F_13690 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511297.1 1340681 R 561276 CDS YP_002511298.1 221232145 7329278 complement(1340959..1341360) 1 NC_011900.1 the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress; Spx family transcriptional regulator 1341360 spxA 7329278 spxA Streptococcus pneumoniae ATCC 700669 Spx family transcriptional regulator YP_002511298.1 1340959 R 561276 CDS YP_002511299.1 221232146 7329151 complement(1341570..1342187) 1 NC_011900.1 hypothetical protein 1342187 7329151 SPN23F_13710 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511299.1 1341570 R 561276 CDS YP_002511300.1 221232147 7329279 complement(1342177..1342950) 1 NC_011900.1 haloacid dehalogenase-like hydrolase 1342950 7329279 SPN23F_13720 Streptococcus pneumoniae ATCC 700669 haloacid dehalogenase-like hydrolase YP_002511300.1 1342177 R 561276 CDS YP_002511301.1 221232148 7329280 complement(1342961..1343698) 1 NC_011900.1 acyl-ACP thioesterase 1343698 7329280 SPN23F_13730 Streptococcus pneumoniae ATCC 700669 acyl-ACP thioesterase YP_002511301.1 1342961 R 561276 CDS YP_002511302.1 221232149 7329281 complement(1343703..1344833) 1 NC_011900.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 1344833 hemN 7329281 hemN Streptococcus pneumoniae ATCC 700669 coproporphyrinogen III oxidase YP_002511302.1 1343703 R 561276 CDS YP_002511303.1 221232150 7328069 complement(1344917..1345306) 1 NC_011900.1 exported hydrophilic protein 1345306 7328069 SPN23F_13750 Streptococcus pneumoniae ATCC 700669 exported hydrophilic protein YP_002511303.1 1344917 R 561276 CDS YP_002511304.1 221232151 7329282 complement(1345322..1345705) 1 NC_011900.1 hypothetical protein 1345705 7329282 SPN23F_13760 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511304.1 1345322 R 561276 CDS YP_002511305.1 221232152 7329283 complement(1345706..1346494) 1 NC_011900.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase 1346494 lgt 7329283 lgt Streptococcus pneumoniae ATCC 700669 prolipoprotein diacylglyceryl transferase YP_002511305.1 1345706 R 561276 CDS YP_002511306.1 221232153 7328106 complement(1346487..1347422) 1 NC_011900.1 catalyzes the phosphorylation of the phosphocarrier protein HPr of the bacterial phosphotransferase system; HPr kinase/phosphorylase 1347422 ptsK 7328106 ptsK Streptococcus pneumoniae ATCC 700669 HPr kinase/phosphorylase YP_002511306.1 1346487 R 561276 CDS YP_002511307.1 221232154 7327894 complement(1347552..1347728) 1 NC_011900.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 1347728 rpsU 7327894 rpsU Streptococcus pneumoniae ATCC 700669 30S ribosomal protein S21 YP_002511307.1 1347552 R 561276 CDS YP_002511308.1 221232155 7329127 complement(1347868..1348575) 1 NC_011900.1 glucosamine-6-phosphate isomerase 1348575 nagB 7329127 nagB Streptococcus pneumoniae ATCC 700669 glucosamine-6-phosphate isomerase YP_002511308.1 1347868 R 561276 CDS YP_002511309.1 221232156 7328413 1348726..1349754 1 NC_011900.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine:tRNA ribosyltransferase-isomerase 1349754 queA 7328413 queA Streptococcus pneumoniae ATCC 700669 S-adenosylmethionine:tRNA ribosyltransferase-isomerase YP_002511309.1 1348726 D 561276 CDS YP_002511310.1 221232157 7329284 complement(1352264..1352815) 1 NC_011900.1 GNAT family acetyltransferase 1352815 7329284 SPN23F_13830 Streptococcus pneumoniae ATCC 700669 GNAT family acetyltransferase YP_002511310.1 1352264 R 561276 CDS YP_002511311.1 221232158 7329285 complement(1353165..1353989) 1 NC_011900.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase 1353989 nadE 7329285 nadE Streptococcus pneumoniae ATCC 700669 NAD synthetase YP_002511311.1 1353165 R 561276 CDS YP_002511312.1 221232159 7328412 complement(1353986..1355446) 1 NC_011900.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase 1355446 7328412 SPN23F_13850 Streptococcus pneumoniae ATCC 700669 nicotinate phosphoribosyltransferase YP_002511312.1 1353986 R 561276 CDS YP_002511313.1 221232160 7329286 complement(1355562..1356050) 1 NC_011900.1 hypothetical protein 1356050 7329286 SPN23F_13860 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511313.1 1355562 R 561276 CDS YP_002511314.1 221232161 7329287 complement(1356040..1356249) 1 NC_011900.1 DNA-binding protein 1356249 7329287 SPN23F_13870 Streptococcus pneumoniae ATCC 700669 DNA-binding protein YP_002511314.1 1356040 R 561276 CDS YP_002511315.1 221232162 7329288 complement(1356635..1357114) 1 NC_011900.1 hypothetical protein 1357114 7329288 SPN23F_13880 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511315.1 1356635 R 561276 CDS YP_002511316.1 221232163 7329291 complement(1358358..1359083) 1 NC_011900.1 peptidase 1359083 7329291 SPN23F_13910 Streptococcus pneumoniae ATCC 700669 peptidase YP_002511316.1 1358358 R 561276 CDS YP_002511317.1 221232164 7329292 complement(1359672..1360958) 1 NC_011900.1 peptidase 1360958 7329292 SPN23F_13930 Streptococcus pneumoniae ATCC 700669 peptidase YP_002511317.1 1359672 R 561276 CDS YP_002511318.1 221232165 7329294 1362136..1363326 1 NC_011900.1 DNA modification methylase 1363326 7329294 SPN23F_13960 Streptococcus pneumoniae ATCC 700669 DNA modification methylase YP_002511318.1 1362136 D 561276 CDS YP_002511319.1 221232166 7329295 complement(1363841..1364833) 1 NC_011900.1 AraC family transcriptional regulator 1364833 7329295 SPN23F_13980 Streptococcus pneumoniae ATCC 700669 AraC family transcriptional regulator YP_002511319.1 1363841 R 561276 CDS YP_002511320.1 221232167 7329296 1364993..1366747 1 NC_011900.1 ABC transporter 1366747 7329296 SPN23F_13990 Streptococcus pneumoniae ATCC 700669 ABC transporter YP_002511320.1 1364993 D 561276 CDS YP_002511321.1 221232168 7329297 1366731..1368452 1 NC_011900.1 ABC transporter 1368452 7329297 SPN23F_14000 Streptococcus pneumoniae ATCC 700669 ABC transporter YP_002511321.1 1366731 D 561276 CDS YP_002511322.1 221232169 7329298 1368463..1369047 1 NC_011900.1 hypothetical protein 1369047 7329298 SPN23F_14010 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511322.1 1368463 D 561276 CDS YP_002511323.1 221232170 7329299 1369047..1369742 1 NC_011900.1 hypothetical protein 1369742 7329299 SPN23F_14020 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511323.1 1369047 D 561276 CDS YP_002511324.1 221232171 7329300 1369730..1371094 1 NC_011900.1 ABC transporter 1371094 7329300 SPN23F_14030 Streptococcus pneumoniae ATCC 700669 ABC transporter YP_002511324.1 1369730 D 561276 CDS YP_002511325.1 221232172 7329303 complement(1373293..1373643) 1 NC_011900.1 transposase 1373643 7329303 SPN23F_14080 Streptococcus pneumoniae ATCC 700669 transposase YP_002511325.1 1373293 R 561276 CDS YP_002511326.1 221232173 7329304 complement(1373624..1373809) 1 NC_011900.1 IS66 family element, orf1 1373809 7329304 SPN23F_14090 Streptococcus pneumoniae ATCC 700669 IS66 family element, orf1 YP_002511326.1 1373624 R 561276 CDS YP_002511327.1 221232174 7329305 complement(1374113..1375675) 1 NC_011900.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 1375675 guaA 7329305 guaA Streptococcus pneumoniae ATCC 700669 GMP synthase YP_002511327.1 1374113 R 561276 CDS YP_002511328.1 221232175 7328063 1375817..1376515 1 NC_011900.1 GntR family transcriptional regulator 1376515 7328063 SPN23F_14110 Streptococcus pneumoniae ATCC 700669 GntR family transcriptional regulator YP_002511328.1 1375817 D 561276 CDS YP_002511329.1 221232176 7329306 complement(1376558..1377454) 1 NC_011900.1 hypothetical protein 1377454 7329306 SPN23F_14120 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511329.1 1376558 R 561276 CDS YP_002511330.1 221232177 7329307 complement(1377463..1378398) 1 NC_011900.1 beta-lactamase 1378398 7329307 SPN23F_14130 Streptococcus pneumoniae ATCC 700669 beta-lactamase YP_002511330.1 1377463 R 561276 CDS YP_002511331.1 221232178 7329308 complement(1378395..1379120) 1 NC_011900.1 hypothetical protein 1379120 7329308 SPN23F_14140 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511331.1 1378395 R 561276 CDS YP_002511332.1 221232179 7329309 complement(1379204..1379839) 1 NC_011900.1 GDSL-like Lipase/acylhydrolase family protein 1379839 7329309 SPN23F_14150 Streptococcus pneumoniae ATCC 700669 GDSL-like Lipase/acylhydrolase family protein YP_002511332.1 1379204 R 561276 CDS YP_002511333.1 221232180 7329310 complement(1379841..1380668) 1 NC_011900.1 haloacid dehalogenase-like hydrolase 1380668 7329310 SPN23F_14160 Streptococcus pneumoniae ATCC 700669 haloacid dehalogenase-like hydrolase YP_002511333.1 1379841 R 561276 CDS YP_002511334.1 221232181 7329312 1382255..1382866 1 NC_011900.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 1382866 def 7329312 def Streptococcus pneumoniae ATCC 700669 peptide deformylase YP_002511334.1 1382255 D 561276 CDS YP_002511335.1 221232182 7329224 1382911..1383639 1 NC_011900.1 SpoU rRNA methylase family protein 1383639 7329224 SPN23F_14210 Streptococcus pneumoniae ATCC 700669 SpoU rRNA methylase family protein YP_002511335.1 1382911 D 561276 CDS YP_002511336.1 221232183 7329313 complement(1383678..1384589) 1 NC_011900.1 thioredoxin reductase 1384589 7329313 SPN23F_14220 Streptococcus pneumoniae ATCC 700669 thioredoxin reductase YP_002511336.1 1383678 R 561276 CDS YP_002511337.1 221232184 7329314 complement(1384655..1384879) 1 NC_011900.1 hypothetical protein 1384879 7329314 SPN23F_14230 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511337.1 1384655 R 561276 CDS YP_002511338.1 221232185 7329315 complement(1384957..1385700) 1 NC_011900.1 ABC transporter ATP-binding protein 1385700 7329315 SPN23F_14240 Streptococcus pneumoniae ATCC 700669 ABC transporter ATP-binding protein YP_002511338.1 1384957 R 561276 CDS YP_002511339.1 221232186 7329316 complement(1385700..1386500) 1 NC_011900.1 ABC transporter permease 1386500 7329316 SPN23F_14250 Streptococcus pneumoniae ATCC 700669 ABC transporter permease YP_002511339.1 1385700 R 561276 CDS YP_002511340.1 221232187 7329317 complement(1386658..1387014) 1 NC_011900.1 ArsC family transcriptional regulator 1387014 7329317 SPN23F_14260 Streptococcus pneumoniae ATCC 700669 ArsC family transcriptional regulator YP_002511340.1 1386658 R 561276 CDS YP_002511341.1 221232188 7329318 complement(1387027..1387539) 1 NC_011900.1 methylated-DNA--protein-cysteine methyltransferase 1387539 ogt 7329318 ogt Streptococcus pneumoniae ATCC 700669 methylated-DNA--protein-cysteine methyltransferase YP_002511341.1 1387027 R 561276 CDS YP_002511342.1 221232189 7328436 complement(1387539..1388033) 1 NC_011900.1 GNAT family acetyltransferase 1388033 7328436 SPN23F_14280 Streptococcus pneumoniae ATCC 700669 GNAT family acetyltransferase YP_002511342.1 1387539 R 561276 CDS YP_002511343.1 221232190 7329319 1388168..1388614 1 NC_011900.1 hypothetical protein 1388614 7329319 SPN23F_14290 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511343.1 1388168 D 561276 CDS YP_002511344.1 221232191 7329320 1388611..1389258 1 NC_011900.1 hemolysin-III-like membrane protein 1389258 7329320 SPN23F_14300 Streptococcus pneumoniae ATCC 700669 hemolysin-III-like membrane protein YP_002511344.1 1388611 D 561276 CDS YP_002511345.1 221232192 7329321 complement(1389279..1389860) 1 NC_011900.1 with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate; glutamine amidotransferase subunit PdxT 1389860 7329321 SPN23F_14310 Streptococcus pneumoniae ATCC 700669 glutamine amidotransferase subunit PdxT YP_002511345.1 1389279 R 561276 CDS YP_002511346.1 221232193 7329322 complement(1389861..1390736) 1 NC_011900.1 with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate; pyridoxal biosynthesis lyase PdxS 1390736 7329322 SPN23F_14320 Streptococcus pneumoniae ATCC 700669 pyridoxal biosynthesis lyase PdxS YP_002511346.1 1389861 R 561276 CDS YP_002511347.1 221232194 7329323 complement(1390888..1392267) 1 NC_011900.1 NADH oxidase 1392267 nox 7329323 nox Streptococcus pneumoniae ATCC 700669 NADH oxidase YP_002511347.1 1390888 R 561276 CDS YP_002511348.1 221232195 7328421 1392561..1393484 1 NC_011900.1 ApbE family protein 1393484 7328421 SPN23F_14350 Streptococcus pneumoniae ATCC 700669 ApbE family protein YP_002511348.1 1392561 D 561276 CDS YP_002511349.1 221232196 7329324 1393544..1394149 1 NC_011900.1 NADPH-dependent FMN reductase 1394149 7329324 SPN23F_14360 Streptococcus pneumoniae ATCC 700669 NADPH-dependent FMN reductase YP_002511349.1 1393544 D 561276 CDS YP_002511350.1 221232197 7329325 1394167..1395411 1 NC_011900.1 NADPH-dependent FMN reductase 1395411 7329325 SPN23F_14370 Streptococcus pneumoniae ATCC 700669 NADPH-dependent FMN reductase YP_002511350.1 1394167 D 561276 CDS YP_002511351.1 221232198 7329326 complement(1395634..1395891) 1 NC_011900.1 hypothetical protein 1395891 7329326 SPN23F_14380 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511351.1 1395634 R 561276 CDS YP_002511352.1 221232199 7329327 complement(1395933..1397969) 1 NC_011900.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta 1397969 glyS 7329327 glyS Streptococcus pneumoniae ATCC 700669 glycyl-tRNA synthetase subunit beta YP_002511352.1 1395933 R 561276 CDS YP_002511353.1 221232200 7328615 complement(1398229..1399146) 1 NC_011900.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha 1399146 glyQ 7328615 glyQ Streptococcus pneumoniae ATCC 700669 glycyl-tRNA synthetase subunit alpha YP_002511353.1 1398229 R 561276 CDS YP_002511354.1 221232201 7328614 complement(1399165..1399926) 1 NC_011900.1 hypothetical protein 1399926 7328614 SPN23F_14410 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511354.1 1399165 R 561276 CDS YP_002511355.1 221232202 7329328 complement(1400199..1401041) 1 NC_011900.1 aldo/keto reductase family protein 1401041 7329328 SPN23F_14420 Streptococcus pneumoniae ATCC 700669 aldo/keto reductase family protein YP_002511355.1 1400199 R 561276 CDS YP_002511356.1 221232203 7329329 complement(1401155..1402492) 1 NC_011900.1 polysaccharide deacetylase 1402492 7329329 SPN23F_14430 Streptococcus pneumoniae ATCC 700669 polysaccharide deacetylase YP_002511356.1 1401155 R 561276 CDS YP_002511357.1 221232204 7329330 complement(1402781..1403158) 1 NC_011900.1 hypothetical protein 1403158 7329330 SPN23F_14440 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511357.1 1402781 R 561276 CDS YP_002511358.1 221232205 7329331 1403373..1404350 1 NC_011900.1 oxidoreductase 1404350 7329331 SPN23F_14450 Streptococcus pneumoniae ATCC 700669 oxidoreductase YP_002511358.1 1403373 D 561276 CDS YP_002511359.1 221232206 7329332 1404347..1405429 1 NC_011900.1 RNA helicase 1405429 7329332 SPN23F_14460 Streptococcus pneumoniae ATCC 700669 RNA helicase YP_002511359.1 1404347 D 561276 CDS YP_002511360.1 221232207 7329336 complement(1408400..1409596) 1 NC_011900.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 1409596 tufA 7329336 tufA Streptococcus pneumoniae ATCC 700669 elongation factor Tu YP_002511360.1 1408400 R 561276 CDS YP_002511361.1 221232208 7327656 complement(1409760..1410713) 1 NC_011900.1 IS1239 transposase 1410713 7327656 SPN23F_14540 Streptococcus pneumoniae ATCC 700669 IS1239 transposase YP_002511361.1 1409760 R 561276 CDS YP_002511362.1 221232209 7329337 complement(1411751..1412620) 1 NC_011900.1 glycerol facilitator-aquaporin 1412620 gla 7329337 gla Streptococcus pneumoniae ATCC 700669 glycerol facilitator-aquaporin YP_002511362.1 1411751 R 561276 CDS YP_002511363.1 221232210 7329338 complement(1414540..1414791) 1 NC_011900.1 hypothetical protein 1414791 7329338 SPN23F_14590 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511363.1 1414540 R 561276 CDS YP_002511364.1 221232211 7328703 1416213..1417931 1 NC_011900.1 phosphomannomutase 1417931 pgmA 7328703 pgmA Streptococcus pneumoniae ATCC 700669 phosphomannomutase YP_002511364.1 1416213 D 561276 CDS YP_002511365.1 221232212 7327839 1418042..1418389 1 NC_011900.1 hypothetical protein 1418389 7327839 SPN23F_14640 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511365.1 1418042 D 561276 CDS YP_002511366.1 221232213 7328704 complement(1418667..1419503) 1 NC_011900.1 amino acid ABC transporter substrate-binding protein 1419503 7328704 SPN23F_14650 Streptococcus pneumoniae ATCC 700669 amino acid ABC transporter substrate-binding protein YP_002511366.1 1418667 R 561276 CDS YP_002511367.1 221232214 7328705 complement(1419516..1420145) 1 NC_011900.1 amino acid ABC transporter ATP-binding protein 1420145 7328705 SPN23F_14660 Streptococcus pneumoniae ATCC 700669 amino acid ABC transporter ATP-binding protein YP_002511367.1 1419516 R 561276 CDS YP_002511368.1 221232215 7328706 complement(1420155..1420796) 1 NC_011900.1 amino acid ABC transporter permease 1420796 7328706 SPN23F_14670 Streptococcus pneumoniae ATCC 700669 amino acid ABC transporter permease YP_002511368.1 1420155 R 561276 CDS YP_002511369.1 221232216 7328707 complement(1420942..1422171) 1 NC_011900.1 hypothetical protein 1422171 7328707 SPN23F_14680 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511369.1 1420942 R 561276 CDS YP_002511370.1 221232217 7328708 complement(1422161..1423327) 1 NC_011900.1 hypothetical protein 1423327 7328708 SPN23F_14690 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511370.1 1422161 R 561276 CDS YP_002511371.1 221232218 7328709 1423471..1424484 1 NC_011900.1 hypothetical protein 1424484 7328709 SPN23F_14700 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511371.1 1423471 D 561276 CDS YP_002511372.1 221232219 7328710 complement(1424529..1424948) 1 NC_011900.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; F0F1 ATP synthase subunit epsilon 1424948 atpC 7328710 atpC Streptococcus pneumoniae ATCC 700669 F0F1 ATP synthase subunit epsilon YP_002511372.1 1424529 R 561276 CDS YP_002511373.1 221232220 7328674 complement(1424959..1426365) 1 NC_011900.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; F0F1 ATP synthase subunit beta 1426365 atpD 7328674 atpD Streptococcus pneumoniae ATCC 700669 F0F1 ATP synthase subunit beta YP_002511373.1 1424959 R 561276 CDS YP_002511374.1 221232221 7328675 complement(1426451..1427329) 1 NC_011900.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; F0F1 ATP synthase subunit gamma 1427329 atpG 7328675 atpG Streptococcus pneumoniae ATCC 700669 F0F1 ATP synthase subunit gamma YP_002511374.1 1426451 R 561276 CDS YP_002511375.1 221232222 7328678 complement(1427345..1428850) 1 NC_011900.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; F0F1 ATP synthase subunit alpha 1428850 atpA 7328678 atpA Streptococcus pneumoniae ATCC 700669 F0F1 ATP synthase subunit alpha YP_002511375.1 1427345 R 561276 CDS YP_002511376.1 221232223 7328672 complement(1428865..1429401) 1 NC_011900.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit delta 1429401 atpH 7328672 atpH Streptococcus pneumoniae ATCC 700669 F0F1 ATP synthase subunit delta YP_002511376.1 1428865 R 561276 CDS YP_002511377.1 221232224 7328679 complement(1429401..1429895) 1 NC_011900.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; F0F1 ATP synthase subunit B 1429895 atpF 7328679 atpF Streptococcus pneumoniae ATCC 700669 F0F1 ATP synthase subunit B YP_002511377.1 1429401 R 561276 CDS YP_002511378.1 221232225 7328677 complement(1429909..1430625) 1 NC_011900.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; F0F1 ATP synthase subunit A 1430625 atpB 7328677 atpB Streptococcus pneumoniae ATCC 700669 F0F1 ATP synthase subunit A YP_002511378.1 1429909 R 561276 CDS YP_002511379.1 221232226 7328673 complement(1430660..1430860) 1 NC_011900.1 produces ATP from ADP in the presence of a proton gradient across the membrane; subunit C is part of the membrane proton channel F0; F0F1 ATP synthase subunit C 1430860 atpE 7328673 atpE Streptococcus pneumoniae ATCC 700669 F0F1 ATP synthase subunit C YP_002511379.1 1430660 R 561276 CDS YP_002511380.1 221232227 7328676 complement(1430935..1431942) 1 NC_011900.1 insertion sequence IS1239 transposase 1431942 7328676 SPN23F_14790 Streptococcus pneumoniae ATCC 700669 insertion sequence IS1239 transposase YP_002511380.1 1430935 R 561276 CDS YP_002511381.1 221232228 7328711 complement(1432387..1432815) 1 NC_011900.1 acetyltransferase 1432815 7328711 SPN23F_14800 Streptococcus pneumoniae ATCC 700669 acetyltransferase YP_002511381.1 1432387 R 561276 CDS YP_002511382.1 221232229 7328712 complement(1433113..1433595) 1 NC_011900.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA 1433595 greA 7328712 greA Streptococcus pneumoniae ATCC 700669 transcription elongation factor GreA YP_002511382.1 1433113 R 561276 CDS YP_002511383.1 221232230 7328621 complement(1433666..1435321) 1 NC_011900.1 aminodeoxychorismate lyase 1435321 7328621 SPN23F_14820 Streptococcus pneumoniae ATCC 700669 aminodeoxychorismate lyase YP_002511383.1 1433666 R 561276 CDS YP_002511384.1 221232231 7328713 complement(1435402..1435896) 1 NC_011900.1 GNAT family acetyltransferase 1435896 7328713 SPN23F_14830 Streptococcus pneumoniae ATCC 700669 GNAT family acetyltransferase YP_002511384.1 1435402 R 561276 CDS YP_002511385.1 221232232 7328714 complement(1435893..1436357) 1 NC_011900.1 GNAT family acetyltransferase. GNAT family acetyltransferase 1436357 7328714 SPN23F_14840 Streptococcus pneumoniae ATCC 700669 GNAT family acetyltransferase. GNAT family acetyltransferase YP_002511385.1 1435893 R 561276 CDS YP_002511386.1 221232233 7328715 complement(1436367..1437701) 1 NC_011900.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 1437701 murC 7328715 murC Streptococcus pneumoniae ATCC 700669 UDP-N-acetylmuramate--L-alanine ligase YP_002511386.1 1436367 R 561276 CDS YP_002511387.1 221232234 7328393 complement(1437712..1438350) 1 NC_011900.1 ATP-binding protein 1438350 7328393 SPN23F_14860 Streptococcus pneumoniae ATCC 700669 ATP-binding protein YP_002511387.1 1437712 R 561276 CDS YP_002511388.1 221232235 7328716 complement(1438398..1441496) 1 NC_011900.1 SNF-family helicase 1441496 7328716 SPN23F_14870 Streptococcus pneumoniae ATCC 700669 SNF-family helicase YP_002511388.1 1438398 R 561276 CDS YP_002511389.1 221232236 7328717 complement(1441589..1442755) 1 NC_011900.1 aminotransferase 1442755 7328717 SPN23F_14880 Streptococcus pneumoniae ATCC 700669 aminotransferase YP_002511389.1 1441589 R 561276 CDS YP_002511390.1 221232237 7328718 complement(1442763..1443857) 1 NC_011900.1 catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; cystathionine gamma-synthase 1443857 7328718 SPN23F_14890 Streptococcus pneumoniae ATCC 700669 cystathionine gamma-synthase YP_002511390.1 1442763 R 561276 CDS YP_002511391.1 221232238 7328719 complement(1444015..1445697) 1 NC_011900.1 ABC transporter ATP-binding protein 1445697 7328719 SPN23F_14900 Streptococcus pneumoniae ATCC 700669 ABC transporter ATP-binding protein YP_002511391.1 1444015 R 561276 CDS YP_002511392.1 221232239 7328720 complement(1445869..1447827) 1 NC_011900.1 extracellular oligopeptide-binding protein 1447827 7328720 SPN23F_14910 Streptococcus pneumoniae ATCC 700669 extracellular oligopeptide-binding protein YP_002511392.1 1445869 R 561276 CDS YP_002511393.1 221232240 7328721 complement(1448031..1449653) 1 NC_011900.1 polysaccharide biosynthesis protein 1449653 7328721 SPN23F_14920 Streptococcus pneumoniae ATCC 700669 polysaccharide biosynthesis protein YP_002511393.1 1448031 R 561276 CDS YP_002511394.1 221232241 7328722 1449759..1451204 1 NC_011900.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of lysine to UDP-N-acetylmuramoyl-L-alanyl-D-glutamate forming UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine; UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase 1451204 murE 7328722 murE Streptococcus pneumoniae ATCC 700669 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase YP_002511394.1 1449759 D 561276 CDS YP_002511395.1 221232242 7328395 complement(1451247..1451444) 1 NC_011900.1 CsbD-like protein 1451444 7328395 SPN23F_14940 Streptococcus pneumoniae ATCC 700669 CsbD-like protein YP_002511395.1 1451247 R 561276 CDS YP_002511396.1 221232243 7328723 complement(1451545..1452141) 1 NC_011900.1 hypothetical protein 1452141 7328723 SPN23F_14950 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511396.1 1451545 R 561276 CDS YP_002511397.1 221232244 7328724 complement(1452178..1452690) 1 NC_011900.1 hypothetical protein 1452690 7328724 SPN23F_14960 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511397.1 1452178 R 561276 CDS YP_002511398.1 221232245 7328725 complement(1452776..1453711) 1 NC_011900.1 catalyzes the hydrolysis of pyrophosphate to phosphate; manganese-dependent inorganic pyrophosphatase 1453711 ppaC 7328725 ppaC Streptococcus pneumoniae ATCC 700669 manganese-dependent inorganic pyrophosphatase YP_002511398.1 1452776 R 561276 CDS YP_002511399.1 221232246 7327869 complement(1453782..1454081) 1 NC_011900.1 hypothetical protein 1454081 7327869 SPN23F_14980 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511399.1 1453782 R 561276 CDS YP_002511400.1 221232247 7328726 complement(1454071..1454820) 1 NC_011900.1 hypothetical protein 1454820 7328726 SPN23F_14990 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511400.1 1454071 R 561276 CDS YP_002511401.1 221232248 7328727 complement(1454874..1455233) 1 NC_011900.1 hypothetical protein 1455233 7328727 SPN23F_15000 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511401.1 1454874 R 561276 CDS YP_002511402.1 221232249 7328728 complement(1455235..1456635) 1 NC_011900.1 cyclophilin type peptidyl-prolyl cis-trans isomerase protein 1456635 7328728 SPN23F_15010 Streptococcus pneumoniae ATCC 700669 cyclophilin type peptidyl-prolyl cis-trans isomerase protein YP_002511402.1 1455235 R 561276 CDS YP_002511403.1 221232250 7328729 complement(1456930..1457169) 1 NC_011900.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 1457169 rpsR 7328729 rpsR Streptococcus pneumoniae ATCC 700669 30S ribosomal protein S18 YP_002511403.1 1456930 R 561276 CDS YP_002511404.1 221232251 7329124 complement(1457201..1457671) 1 NC_011900.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein 1457671 ssb 7329124 ssb Streptococcus pneumoniae ATCC 700669 single-stranded DNA-binding protein YP_002511404.1 1457201 R 561276 CDS YP_002511405.1 221232252 7329154 complement(1457683..1457973) 1 NC_011900.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 1457973 rpsF 7329154 rpsF Streptococcus pneumoniae ATCC 700669 30S ribosomal protein S6 YP_002511405.1 1457683 R 561276 CDS YP_002511406.1 221232253 7329113 complement(1458126..1459469) 1 NC_011900.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; asparaginyl-tRNA synthetase 1459469 asnC 7329113 asnC Streptococcus pneumoniae ATCC 700669 asparaginyl-tRNA synthetase YP_002511406.1 1458126 R 561276 CDS YP_002511407.1 221232254 7328669 complement(1459488..1459853) 1 NC_011900.1 hypothetical protein 1459853 7328669 SPN23F_15060 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511407.1 1459488 R 561276 CDS YP_002511408.1 221232255 7328730 complement(1459846..1461033) 1 NC_011900.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; aspartate aminotransferase 1461033 aspC 7328730 aspC Streptococcus pneumoniae ATCC 700669 aspartate aminotransferase YP_002511408.1 1459846 R 561276 CDS YP_002511409.1 221232256 7328670 complement(1461030..1461518) 1 NC_011900.1 hypothetical protein 1461518 7328670 SPN23F_15080 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511409.1 1461030 R 561276 CDS YP_002511410.1 221232257 7328731 1461839..1462387 1 NC_011900.1 NADPH-dependent FMN reductase 1462387 pclA 7328731 pclA Streptococcus pneumoniae ATCC 700669 NADPH-dependent FMN reductase YP_002511410.1 1461839 D 561276 CDS YP_002511411.1 221232258 7328458 complement(1462624..1467948) 1 NC_011900.1 collagen-like surface-anchored protein 1467948 7328458 SPN23F_15110 Streptococcus pneumoniae ATCC 700669 collagen-like surface-anchored protein YP_002511411.1 1462624 R 561276 CDS YP_002511412.1 221232259 7328732 1468164..1469648 1 NC_011900.1 Mga-like regulatory protein 1469648 7328732 SPN23F_15120 Streptococcus pneumoniae ATCC 700669 Mga-like regulatory protein YP_002511412.1 1468164 D 561276 CDS YP_002511413.1 221232260 7328733 complement(1469699..1470427) 1 NC_011900.1 hypothetical protein 1470427 7328733 SPN23F_15130 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511413.1 1469699 R 561276 CDS YP_002511414.1 221232261 7328734 complement(1470849..1472444) 1 NC_011900.1 hypothetical protein 1472444 7328734 SPN23F_15150 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511414.1 1470849 R 561276 CDS YP_002511415.1 221232262 7328735 complement(1472456..1472866) 1 NC_011900.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 1472866 fms 7328735 fms Streptococcus pneumoniae ATCC 700669 peptide deformylase YP_002511415.1 1472456 R 561276 CDS YP_002511416.1 221232263 7328555 complement(1472982..1473773) 1 NC_011900.1 YghU; B2989; one of eight glutathione transferase proteins from E. coli; glutathione S-transferase YghU 1473773 7328555 SPN23F_15170 Streptococcus pneumoniae ATCC 700669 glutathione S-transferase YghU YP_002511416.1 1472982 R 561276 CDS YP_002511417.1 221232264 7328736 complement(1473786..1476482) 1 NC_011900.1 cation transporting ATPase 1476482 7328736 SPN23F_15180 Streptococcus pneumoniae ATCC 700669 cation transporting ATPase YP_002511417.1 1473786 R 561276 CDS YP_002511418.1 221232265 7329471 1476786..1477970 1 NC_011900.1 cation efflux family protein 1477970 7329471 SPN23F_15190 Streptococcus pneumoniae ATCC 700669 cation efflux family protein YP_002511418.1 1476786 D 561276 CDS YP_002511419.1 221232266 7328738 complement(1478113..1479984) 1 NC_011900.1 ABC transporter ATP-binding protein 1479984 7328738 SPN23F_15200 Streptococcus pneumoniae ATCC 700669 ABC transporter ATP-binding protein YP_002511419.1 1478113 R 561276 CDS YP_002511420.1 221232267 7328739 complement(1479981..1481165) 1 NC_011900.1 catalyzes the addition and repair of the 3'-terminal CCA sequence in tRNA; these proteins belong to the CCA-adding enzyme subfamily 2 which does not have phosphohydrolase activity; tRNA CCA-pyrophosphorylase 1481165 cca 7328739 cca Streptococcus pneumoniae ATCC 700669 tRNA CCA-pyrophosphorylase YP_002511420.1 1479981 R 561276 CDS YP_002511421.1 221232268 7329186 complement(1481177..1481944) 1 NC_011900.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase 1481944 dapB 7329186 dapB Streptococcus pneumoniae ATCC 700669 dihydrodipicolinate reductase YP_002511421.1 1481177 R 561276 CDS YP_002511422.1 221232269 7329222 complement(1482210..1483058) 1 NC_011900.1 DegV family protein 1483058 7329222 SPN23F_15230 Streptococcus pneumoniae ATCC 700669 DegV family protein YP_002511422.1 1482210 R 561276 CDS YP_002511423.1 221232270 7328740 complement(1483060..1483434) 1 NC_011900.1 hypothetical protein 1483434 7328740 SPN23F_15240 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511423.1 1483060 R 561276 CDS YP_002511424.1 221232271 7328741 complement(1483508..1484860) 1 NC_011900.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase 1484860 glmM 7328741 glmM Streptococcus pneumoniae ATCC 700669 phosphoglucosamine mutase YP_002511424.1 1483508 R 561276 CDS YP_002511425.1 221232272 7328742 complement(1484884..1485663) 1 NC_011900.1 hypothetical protein 1485663 7328742 SPN23F_15260 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511425.1 1484884 R 561276 CDS YP_002511426.1 221232273 7328743 complement(1485650..1486507) 1 NC_011900.1 hypothetical protein 1486507 7328743 SPN23F_15270 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511426.1 1485650 R 561276 CDS YP_002511427.1 221232274 7328744 1486643..1487611 1 NC_011900.1 pyridine nucleotide-disulfide oxidoreductase family protein 1487611 7328744 SPN23F_15280 Streptococcus pneumoniae ATCC 700669 pyridine nucleotide-disulfide oxidoreductase family protein YP_002511427.1 1486643 D 561276 CDS YP_002511428.1 221232275 7328745 complement(1487864..1488820) 1 NC_011900.1 autolysin 1488820 7328745 SPN23F_15290 Streptococcus pneumoniae ATCC 700669 autolysin YP_002511428.1 1487864 R 561276 CDS YP_002511429.1 221232276 7328746 complement(1488824..1489156) 1 NC_011900.1 antiholin 1489156 hol 7328746 hol Streptococcus pneumoniae ATCC 700669 antiholin YP_002511429.1 1488824 R 561276 CDS YP_002511430.1 221232277 7328072 complement(1489160..1489576) 1 NC_011900.1 holin 1489576 7328072 SPN23F_15310 Streptococcus pneumoniae ATCC 700669 holin YP_002511430.1 1489160 R 561276 CDS YP_002511431.1 221232278 7328747 complement(1489586..1489849) 1 NC_011900.1 prophage protein 1489849 7328747 SPN23F_15320 Streptococcus pneumoniae ATCC 700669 prophage protein YP_002511431.1 1489586 R 561276 CDS YP_002511432.1 221232279 7328748 complement(1489909..1491987) 1 NC_011900.1 phage structural protein 1491987 7328748 SPN23F_15330 Streptococcus pneumoniae ATCC 700669 phage structural protein YP_002511432.1 1489909 R 561276 CDS YP_002511433.1 221232280 7328749 complement(1491998..1497025) 1 NC_011900.1 platelet-binding phage protein 1497025 7328749 SPN23F_15340 Streptococcus pneumoniae ATCC 700669 platelet-binding phage protein YP_002511433.1 1491998 R 561276 CDS YP_002511434.1 221232281 7328750 complement(1497027..1498508) 1 NC_011900.1 phage tail protein 1498508 7328750 SPN23F_15350 Streptococcus pneumoniae ATCC 700669 phage tail protein YP_002511434.1 1497027 R 561276 CDS YP_002511435.1 221232282 7328751 complement(1498538..1501819) 1 NC_011900.1 phage minor tail protein 1501819 7328751 SPN23F_15360 Streptococcus pneumoniae ATCC 700669 phage minor tail protein YP_002511435.1 1498538 R 561276 CDS YP_002511436.1 221232283 7328752 complement(1501812..1502381) 1 NC_011900.1 phage Gp15 protein 1502381 7328752 SPN23F_15370 Streptococcus pneumoniae ATCC 700669 phage Gp15 protein YP_002511436.1 1501812 R 561276 CDS YP_002511437.1 221232284 7328753 complement(1502394..1502882) 1 NC_011900.1 hypothetical protein 1502882 7328753 SPN23F_15380 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511437.1 1502394 R 561276 CDS YP_002511438.1 221232285 7328754 complement(1502947..1503396) 1 NC_011900.1 hypothetical protein 1503396 7328754 SPN23F_15390 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511438.1 1502947 R 561276 CDS YP_002511439.1 221232286 7328755 complement(1503393..1503800) 1 NC_011900.1 hypothetical protein 1503800 7328755 SPN23F_15400 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511439.1 1503393 R 561276 CDS YP_002511440.1 221232287 7328756 complement(1503800..1504144) 1 NC_011900.1 hypothetical protein 1504144 7328756 SPN23F_15410 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511440.1 1503800 R 561276 CDS YP_002511441.1 221232288 7328757 complement(1504144..1504515) 1 NC_011900.1 hypothetical protein 1504515 7328757 SPN23F_15420 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511441.1 1504144 R 561276 CDS YP_002511442.1 221232289 7328758 complement(1504505..1504897) 1 NC_011900.1 hypothetical protein 1504897 7328758 SPN23F_15430 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511442.1 1504505 R 561276 CDS YP_002511443.1 221232290 7328759 complement(1504940..1505173) 1 NC_011900.1 hypothetical protein 1505173 7328759 SPN23F_15440 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511443.1 1504940 R 561276 CDS YP_002511444.1 221232291 7328760 complement(1505184..1506065) 1 NC_011900.1 phage capsid protein 1506065 7328760 SPN23F_15450 Streptococcus pneumoniae ATCC 700669 phage capsid protein YP_002511444.1 1505184 R 561276 CDS YP_002511445.1 221232292 7328761 complement(1506083..1506646) 1 NC_011900.1 phage scaffolding protein 1506646 7328761 SPN23F_15460 Streptococcus pneumoniae ATCC 700669 phage scaffolding protein YP_002511445.1 1506083 R 561276 CDS YP_002511446.1 221232293 7328762 complement(1506785..1507936) 1 NC_011900.1 minor capsid protein 1507936 7328762 SPN23F_15470 Streptococcus pneumoniae ATCC 700669 minor capsid protein YP_002511446.1 1506785 R 561276 CDS YP_002511447.1 221232294 7328763 complement(1508139..1509707) 1 NC_011900.1 minor capsid protein 1509707 7328763 SPN23F_15490 Streptococcus pneumoniae ATCC 700669 minor capsid protein YP_002511447.1 1508139 R 561276 CDS YP_002511448.1 221232295 7328764 complement(1509720..1511030) 1 NC_011900.1 phage terminase large subunit 1511030 7328764 SPN23F_15500 Streptococcus pneumoniae ATCC 700669 phage terminase large subunit YP_002511448.1 1509720 R 561276 CDS YP_002511449.1 221232296 7328765 complement(1511020..1511475) 1 NC_011900.1 hypothetical protein 1511475 7328765 SPN23F_15510 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511449.1 1511020 R 561276 CDS YP_002511450.1 221232297 7328766 complement(1511679..1512425) 1 NC_011900.1 hypothetical protein 1512425 7328766 SPN23F_15520 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511450.1 1511679 R 561276 CDS YP_002511451.1 221232298 7328767 complement(1512406..1513494) 1 NC_011900.1 hypothetical protein 1513494 7328767 SPN23F_15530 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511451.1 1512406 R 561276 CDS YP_002511452.1 221232299 7328768 complement(1513566..1513958) 1 NC_011900.1 hypothetical protein 1513958 7328768 SPN23F_15540 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511452.1 1513566 R 561276 CDS YP_002511453.1 221232300 7328769 complement(1513955..1514197) 1 NC_011900.1 hypothetical protein 1514197 7328769 SPN23F_15550 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511453.1 1513955 R 561276 CDS YP_002511454.1 221232301 7328770 complement(1514257..1514631) 1 NC_011900.1 hypothetical protein 1514631 7328770 SPN23F_15560 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511454.1 1514257 R 561276 CDS YP_002511455.1 221232302 7328771 complement(1514691..1514864) 1 NC_011900.1 hypothetical protein 1514864 7328771 SPN23F_15570 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511455.1 1514691 R 561276 CDS YP_002511456.1 221232303 7328772 complement(1514864..1515151) 1 NC_011900.1 hypothetical protein 1515151 7328772 SPN23F_15580 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511456.1 1514864 R 561276 CDS YP_002511457.1 221232304 7328773 complement(1515151..1515648) 1 NC_011900.1 hypothetical protein 1515648 7328773 SPN23F_15590 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511457.1 1515151 R 561276 CDS YP_002511458.1 221232305 7328774 complement(1515650..1515967) 1 NC_011900.1 hypothetical protein 1515967 7328774 SPN23F_15600 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511458.1 1515650 R 561276 CDS YP_002511459.1 221232306 7328775 complement(1516016..1516222) 1 NC_011900.1 hypothetical protein 1516222 7328775 SPN23F_15610 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511459.1 1516016 R 561276 CDS YP_002511460.1 221232307 7328776 complement(1516224..1516625) 1 NC_011900.1 phage Holliday junction resolvase 1516625 7328776 SPN23F_15620 Streptococcus pneumoniae ATCC 700669 phage Holliday junction resolvase YP_002511460.1 1516224 R 561276 CDS YP_002511461.1 221232308 7328777 complement(1516636..1516848) 1 NC_011900.1 phage protein 1516848 7328777 SPN23F_15630 Streptococcus pneumoniae ATCC 700669 phage protein YP_002511461.1 1516636 R 561276 CDS YP_002511462.1 221232309 7328778 complement(1516865..1517602) 1 NC_011900.1 phage protein 1517602 7328778 SPN23F_15640 Streptococcus pneumoniae ATCC 700669 phage protein YP_002511462.1 1516865 R 561276 CDS YP_002511463.1 221232310 7328779 complement(1517604..1518038) 1 NC_011900.1 phage protein 1518038 7328779 SPN23F_15650 Streptococcus pneumoniae ATCC 700669 phage protein YP_002511463.1 1517604 R 561276 CDS YP_002511464.1 221232311 7328780 complement(1518092..1518295) 1 NC_011900.1 hypothetical protein 1518295 7328780 SPN23F_15660 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511464.1 1518092 R 561276 CDS YP_002511465.1 221232312 7328781 complement(1518330..1519439) 1 NC_011900.1 DNA methylase 1519439 7328781 SPN23F_15670 Streptococcus pneumoniae ATCC 700669 DNA methylase YP_002511465.1 1518330 R 561276 CDS YP_002511466.1 221232313 7328782 complement(1519513..1520058) 1 NC_011900.1 single-strand DNA-binding protein 1520058 ssb 7328782 ssb Streptococcus pneumoniae ATCC 700669 single-strand DNA-binding protein YP_002511466.1 1519513 R 561276 CDS YP_002511467.1 221232314 7329155 complement(1520246..1521238) 1 NC_011900.1 hypothetical protein 1521238 7329155 SPN23F_15700 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511467.1 1520246 R 561276 CDS YP_002511468.1 221232315 7328783 complement(1521241..1521948) 1 NC_011900.1 phage single-strand DNA binding protein 1521948 ssb1 7328783 ssb1 Streptococcus pneumoniae ATCC 700669 phage single-strand DNA binding protein YP_002511468.1 1521241 R 561276 CDS YP_002511469.1 221232316 7329156 complement(1521954..1522406) 1 NC_011900.1 hypothetical protein 1522406 7329156 SPN23F_15720 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511469.1 1521954 R 561276 CDS YP_002511470.1 221232317 7328784 complement(1522458..1522982) 1 NC_011900.1 hypothetical protein 1522982 7328784 SPN23F_15730 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511470.1 1522458 R 561276 CDS YP_002511471.1 221232318 7328785 complement(1523063..1523329) 1 NC_011900.1 hypothetical protein 1523329 7328785 SPN23F_15740 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511471.1 1523063 R 561276 CDS YP_002511472.1 221232319 7328786 complement(1523561..1523824) 1 NC_011900.1 hypothetical protein 1523824 7328786 SPN23F_15750 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511472.1 1523561 R 561276 CDS YP_002511473.1 221232320 7328787 complement(1524002..1524193) 1 NC_011900.1 phage DNA-binding protein 1524193 7328787 SPN23F_15760 Streptococcus pneumoniae ATCC 700669 phage DNA-binding protein YP_002511473.1 1524002 R 561276 CDS YP_002511474.1 221232321 7328788 1524490..1524852 1 NC_011900.1 DNA-binding protein 1524852 7328788 SPN23F_15770 Streptococcus pneumoniae ATCC 700669 DNA-binding protein YP_002511474.1 1524490 D 561276 CDS YP_002511475.1 221232322 7328789 1524874..1525254 1 NC_011900.1 hypothetical protein 1525254 7328789 SPN23F_15780 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511475.1 1524874 D 561276 CDS YP_002511476.1 221232323 7328790 1525268..1525618 1 NC_011900.1 phage protein 1525618 7328790 SPN23F_15790 Streptococcus pneumoniae ATCC 700669 phage protein YP_002511476.1 1525268 D 561276 CDS YP_002511477.1 221232324 7328791 1525737..1526864 1 NC_011900.1 phage integrase 1526864 7328791 SPN23F_15800 Streptococcus pneumoniae ATCC 700669 phage integrase YP_002511477.1 1525737 D 561276 CDS YP_002511478.1 221232325 7328792 complement(1526952..1527863) 1 NC_011900.1 hypothetical protein 1527863 7328792 SPN23F_15810 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511478.1 1526952 R 561276 CDS YP_002511479.1 221232326 7328793 complement(1527860..1528837) 1 NC_011900.1 hypothetical protein 1528837 7328793 SPN23F_15820 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511479.1 1527860 R 561276 CDS YP_002511480.1 221232327 7328794 complement(1528834..1529724) 1 NC_011900.1 hypothetical protein 1529724 7328794 SPN23F_15830 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511480.1 1528834 R 561276 CDS YP_002511481.1 221232328 7328795 complement(1529776..1530156) 1 NC_011900.1 endoribonuclease L-PSP family protein 1530156 7328795 SPN23F_15840 Streptococcus pneumoniae ATCC 700669 endoribonuclease L-PSP family protein YP_002511481.1 1529776 R 561276 CDS YP_002511482.1 221232329 7328796 complement(1530167..1530754) 1 NC_011900.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC 1530754 engB 7328796 engB Streptococcus pneumoniae ATCC 700669 ribosome biogenesis GTP-binding protein YsxC YP_002511482.1 1530167 R 561276 CDS YP_002511483.1 221232330 7329254 complement(1530763..1531995) 1 NC_011900.1 binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 1531995 clpX 7329254 clpX Streptococcus pneumoniae ATCC 700669 ATP-dependent protease ATP-binding subunit ClpX YP_002511483.1 1530763 R 561276 CDS YP_002511484.1 221232331 7329199 complement(1532027..1532197) 1 NC_011900.1 hypothetical protein 1532197 7329199 SPN23F_15870 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511484.1 1532027 R 561276 CDS YP_002511485.1 221232332 7328797 complement(1532197..1532703) 1 NC_011900.1 dihydrofolate reductase 1532703 dyr 7328797 dyr Streptococcus pneumoniae ATCC 700669 dihydrofolate reductase YP_002511485.1 1532197 R 561276 CDS YP_002511486.1 221232333 7329249 complement(1532833..1533351) 1 NC_011900.1 Dps-like peroxide resistance protein Dpr 1533351 dpr 7329249 dpr Streptococcus pneumoniae ATCC 700669 Dps-like peroxide resistance protein Dpr YP_002511486.1 1532833 R 561276 CDS YP_002511487.1 221232334 7329248 complement(1533849..1535321) 1 NC_011900.1 exported choline-binding glycosyl hydrolase 1535321 7329248 SPN23F_15900 Streptococcus pneumoniae ATCC 700669 exported choline-binding glycosyl hydrolase YP_002511487.1 1533849 R 561276 CDS YP_002511488.1 221232335 7328798 complement(1535392..1536150) 1 NC_011900.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 1536150 tpiA 7328798 tpiA Streptococcus pneumoniae ATCC 700669 triosephosphate isomerase YP_002511488.1 1535392 R 561276 CDS YP_002511489.1 221232336 7329180 complement(1536248..1536925) 1 NC_011900.1 DNA replication protein DnaD 1536925 7329180 SPN23F_15920 Streptococcus pneumoniae ATCC 700669 DNA replication protein DnaD YP_002511489.1 1536248 R 561276 CDS YP_002511490.1 221232337 7328799 complement(1536934..1537878) 1 NC_011900.1 catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis; homoserine O-succinyltransferase 1537878 metA 7328799 metA Streptococcus pneumoniae ATCC 700669 homoserine O-succinyltransferase YP_002511490.1 1536934 R 561276 CDS YP_002511491.1 221232338 7328125 complement(1538060..1538572) 1 NC_011900.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 1538572 apt 7328125 apt Streptococcus pneumoniae ATCC 700669 adenine phosphoribosyltransferase YP_002511491.1 1538060 R 561276 CDS YP_002511492.1 221232339 7328650 complement(1538660..1539418) 1 NC_011900.1 methyltransferase 1539418 7328650 SPN23F_15950 Streptococcus pneumoniae ATCC 700669 methyltransferase YP_002511492.1 1538660 R 561276 CDS YP_002511493.1 221232340 7328800 1539626..1539796 1 NC_011900.1 hypothetical protein 1539796 7328800 SPN23F_15960 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511493.1 1539626 D 561276 CDS YP_002511494.1 221232341 7328801 complement(1539919..1541049) 1 NC_011900.1 multiple sugar-binding transport ATP-binding protein 1541049 msmK 7328801 msmK Streptococcus pneumoniae ATCC 700669 multiple sugar-binding transport ATP-binding protein YP_002511494.1 1539919 R 561276 CDS YP_002511495.1 221232342 7327615 complement(1541499..1542074) 1 NC_011900.1 isochorismatase family protein 1542074 7327615 SPN23F_15990 Streptococcus pneumoniae ATCC 700669 isochorismatase family protein YP_002511495.1 1541499 R 561276 CDS YP_002511496.1 221232343 7328802 complement(1542074..1542862) 1 NC_011900.1 CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase (By similarity). It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; transcriptional repressor CodY 1542862 codY 7328802 codY Streptococcus pneumoniae ATCC 700669 transcriptional repressor CodY YP_002511496.1 1542074 R 561276 CDS YP_002511497.1 221232344 7329205 complement(1543127..1544701) 1 NC_011900.1 DEAD/DEAH box helicase 1544701 7329205 SPN23F_16010 Streptococcus pneumoniae ATCC 700669 DEAD/DEAH box helicase YP_002511497.1 1543127 R 561276 CDS YP_002511498.1 221232345 7328803 complement(1544900..1546126) 1 NC_011900.1 major facilitator superfamily protein 1546126 7328803 SPN23F_16020 Streptococcus pneumoniae ATCC 700669 major facilitator superfamily protein YP_002511498.1 1544900 R 561276 CDS YP_002511499.1 221232346 7328804 1546319..1547635 1 NC_011900.1 Involved in disulfide oxidoreductase activity and electron transport; pyridine nucleotide-disulfide oxidoreductase 1547635 7328804 SPN23F_16030 Streptococcus pneumoniae ATCC 700669 pyridine nucleotide-disulfide oxidoreductase YP_002511499.1 1546319 D 561276 CDS YP_002511500.1 221232347 7328805 1547734..1549077 1 NC_011900.1 Mur ligase family protein 1549077 7328805 SPN23F_16040 Streptococcus pneumoniae ATCC 700669 Mur ligase family protein YP_002511500.1 1547734 D 561276 CDS YP_002511501.1 221232348 7328806 1549077..1549859 1 NC_011900.1 aminotransferase 1549859 7328806 SPN23F_16050 Streptococcus pneumoniae ATCC 700669 aminotransferase YP_002511501.1 1549077 D 561276 CDS YP_002511502.1 221232349 7328807 1549985..1551067 1 NC_011900.1 Xaa-Pro dipeptidase 1551067 pepQ 7328807 pepQ Streptococcus pneumoniae ATCC 700669 Xaa-Pro dipeptidase YP_002511502.1 1549985 D 561276 CDS YP_002511503.1 221232350 7327828 1551060..1551263 1 NC_011900.1 GNAT family acetyltransferase 1551263 7327828 SPN23F_16070 Streptococcus pneumoniae ATCC 700669 GNAT family acetyltransferase YP_002511503.1 1551060 D 561276 CDS YP_002511504.1 221232351 7328808 complement(1551391..1552224) 1 NC_011900.1 IS3-Spn1 orf B 1552224 7328808 SPN23F_16080 Streptococcus pneumoniae ATCC 700669 IS3-Spn1 orf B YP_002511504.1 1551391 R 561276 CDS YP_002511505.1 221232352 7328810 complement(1552959..1553420) 1 NC_011900.1 hypothetical protein 1553420 7328810 SPN23F_16100 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511505.1 1552959 R 561276 CDS YP_002511506.1 221232353 7328811 complement(1553398..1554171) 1 NC_011900.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase 1554171 thiD 7328811 thiD Streptococcus pneumoniae ATCC 700669 phosphomethylpyrimidine kinase YP_002511506.1 1553398 R 561276 CDS YP_002511507.1 221232354 7329167 complement(1554161..1554910) 1 NC_011900.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A 1554910 truA 7329167 truA Streptococcus pneumoniae ATCC 700669 tRNA pseudouridine synthase A YP_002511507.1 1554161 R 561276 CDS YP_002511508.1 221232355 7327653 complement(1555223..1556374) 1 NC_011900.1 Major Facilitator Superfamily protein 1556374 7327653 SPN23F_16140 Streptococcus pneumoniae ATCC 700669 Major Facilitator Superfamily protein YP_002511508.1 1555223 R 561276 CDS YP_002511509.1 221232356 7328812 complement(1556614..1557243) 1 NC_011900.1 hypothetical protein 1557243 7328812 SPN23F_16150 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511509.1 1556614 R 561276 CDS YP_002511510.1 221232357 7328813 complement(1557246..1557584) 1 NC_011900.1 PhnA protein 1557584 7328813 SPN23F_16160 Streptococcus pneumoniae ATCC 700669 PhnA protein YP_002511510.1 1557246 R 561276 CDS YP_002511511.1 221232358 7328814 complement(1557715..1558386) 1 NC_011900.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 1558386 cmk 7328814 cmk Streptococcus pneumoniae ATCC 700669 cytidylate kinase YP_002511511.1 1557715 R 561276 CDS YP_002511512.1 221232359 7329200 complement(1558395..1558871) 1 NC_011900.1 hypothetical protein 1558871 7329200 SPN23F_16180 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511512.1 1558395 R 561276 CDS YP_002511513.1 221232360 7328815 1559013..1559129 1 NC_011900.1 hypothetical protein 1559129 7328815 SPN23F_16190 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511513.1 1559013 D 561276 CDS YP_002511514.1 221232361 7328816 complement(1559191..1560144) 1 NC_011900.1 membrane glycosyl transferase 1560144 7328816 SPN23F_16200 Streptococcus pneumoniae ATCC 700669 membrane glycosyl transferase YP_002511514.1 1559191 R 561276 CDS YP_002511515.1 221232362 7328817 complement(1560146..1561165) 1 NC_011900.1 UDP-glucose 4-epimerase 1561165 galE 7328817 galE Streptococcus pneumoniae ATCC 700669 UDP-glucose 4-epimerase YP_002511515.1 1560146 R 561276 CDS YP_002511516.1 221232363 7328580 complement(1561268..1561396) 1 NC_011900.1 hypothetical protein 1561396 7328580 SPN23F_16220 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511516.1 1561268 R 561276 CDS YP_002511517.1 221232364 7328818 complement(1561466..1562569) 1 NC_011900.1 FAD dependent oxidoreductase 1562569 7328818 SPN23F_16230 Streptococcus pneumoniae ATCC 700669 FAD dependent oxidoreductase YP_002511517.1 1561466 R 561276 CDS YP_002511518.1 221232365 7328819 complement(1562586..1563383) 1 NC_011900.1 NIF3 (NGG1p interacting factor 3) family protein 1563383 7328819 SPN23F_16240 Streptococcus pneumoniae ATCC 700669 NIF3 (NGG1p interacting factor 3) family protein YP_002511518.1 1562586 R 561276 CDS YP_002511519.1 221232366 7328820 complement(1563370..1564047) 1 NC_011900.1 hypothetical protein 1564047 7328820 SPN23F_16250 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511519.1 1563370 R 561276 CDS YP_002511520.1 221232367 7328821 complement(1564149..1566485) 1 NC_011900.1 cation-transporting ATPase 1566485 7328821 SPN23F_16260 Streptococcus pneumoniae ATCC 700669 cation-transporting ATPase YP_002511520.1 1564149 R 561276 CDS YP_002511521.1 221232368 7328822 1566618..1567367 1 NC_011900.1 acyltransferase 1567367 7328822 SPN23F_16270 Streptococcus pneumoniae ATCC 700669 acyltransferase YP_002511521.1 1566618 D 561276 CDS YP_002511522.1 221232369 7328823 complement(1567659..1568273) 1 NC_011900.1 cadmium resistance protein 1568273 cadD 7328823 cadD Streptococcus pneumoniae ATCC 700669 cadmium resistance protein YP_002511522.1 1567659 R 561276 CDS YP_002511523.1 221232370 7328699 complement(1569088..1569357) 1 NC_011900.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 1569357 rpsO 7328699 rpsO Streptococcus pneumoniae ATCC 700669 30S ribosomal protein S15 YP_002511523.1 1569088 R 561276 CDS YP_002511524.1 221232371 7329121 complement(1569498..1570127) 1 NC_011900.1 hypothetical protein 1570127 7329121 SPN23F_16300 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511524.1 1569498 R 561276 CDS YP_002511525.1 221232372 7328824 1570365..1570565 1 NC_011900.1 hypothetical protein 1570565 7328824 SPN23F_16310 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511525.1 1570365 D 561276 CDS YP_002511526.1 221232373 7329472 1570996..1571319 1 NC_011900.1 hypothetical protein 1571319 7329472 SPN23F_16320 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511526.1 1570996 D 561276 CDS YP_002511527.1 221232374 7328826 1571377..1573320 1 NC_011900.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); threonyl-tRNA synthetase 1573320 thrS 7328826 thrS Streptococcus pneumoniae ATCC 700669 threonyl-tRNA synthetase YP_002511527.1 1571377 D 561276 CDS YP_002511528.1 221232375 7329174 complement(1573369..1574343) 1 NC_011900.1 sensor histidine kinase protein 1574343 7329174 SPN23F_16340 Streptococcus pneumoniae ATCC 700669 sensor histidine kinase protein YP_002511528.1 1573369 R 561276 CDS YP_002511529.1 221232376 7328827 complement(1574336..1575013) 1 NC_011900.1 response regulator protein 1575013 7328827 SPN23F_16350 Streptococcus pneumoniae ATCC 700669 response regulator protein YP_002511529.1 1574336 R 561276 CDS YP_002511530.1 221232377 7328828 1575169..1576242 1 NC_011900.1 hypothetical protein 1576242 7328828 SPN23F_16360 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511530.1 1575169 D 561276 CDS YP_002511531.1 221232378 7328829 complement(1576703..1577140) 1 NC_011900.1 transcriptional regulator protein 1577140 7328829 SPN23F_16370 Streptococcus pneumoniae ATCC 700669 transcriptional regulator protein YP_002511531.1 1576703 R 561276 CDS YP_002511532.1 221232379 7328830 complement(1577216..1578058) 1 NC_011900.1 metallophosphoesterase protein 1578058 7328830 SPN23F_16380 Streptococcus pneumoniae ATCC 700669 metallophosphoesterase protein YP_002511532.1 1577216 R 561276 CDS YP_002511533.1 221232380 7328831 1578170..1578820 1 NC_011900.1 metal-dependent transcriptional regulator 1578820 scaR 7328831 scaR Streptococcus pneumoniae ATCC 700669 metal-dependent transcriptional regulator YP_002511533.1 1578170 D 561276 CDS YP_002511534.1 221232381 7329131 1579017..1579664 1 NC_011900.1 hypothetical protein 1579664 7329131 SPN23F_16410 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511534.1 1579017 D 561276 CDS YP_002511535.1 221232382 7328832 1579795..1580208 1 NC_011900.1 hypothetical protein 1580208 7328832 SPN23F_16420 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511535.1 1579795 D 561276 CDS YP_002511536.1 221232383 7328834 complement(1580679..1581122) 1 NC_011900.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase 1581122 7328834 SPN23F_16450 Streptococcus pneumoniae ATCC 700669 D-tyrosyl-tRNA(Tyr) deacylase YP_002511536.1 1580679 R 561276 CDS YP_002511537.1 221232384 7328835 complement(1581152..1583374) 1 NC_011900.1 GTP pyrophosphokinase 1583374 relA 7328835 relA Streptococcus pneumoniae ATCC 700669 GTP pyrophosphokinase YP_002511537.1 1581152 R 561276 CDS YP_002511538.1 221232385 7327449 1584370..1584999 1 NC_011900.1 metallo-beta-lactamase superfamily protein 1584999 7327449 SPN23F_16480 Streptococcus pneumoniae ATCC 700669 metallo-beta-lactamase superfamily protein YP_002511538.1 1584370 D 561276 CDS YP_002511539.1 221232386 7328836 complement(1585122..1587014) 1 NC_011900.1 endopeptidase O 1587014 pepO 7328836 pepO Streptococcus pneumoniae ATCC 700669 endopeptidase O YP_002511539.1 1585122 R 561276 CDS YP_002511540.1 221232387 7327827 1587305..1588027 1 NC_011900.1 metal cation ABC transporter ATP-binding protein 1588027 mtsB 7327827 mtsB Streptococcus pneumoniae ATCC 700669 metal cation ABC transporter ATP-binding protein YP_002511540.1 1587305 D 561276 CDS YP_002511541.1 221232388 7328389 1588024..1588872 1 NC_011900.1 metal cation ABC transporter membrane protein 1588872 mtsC 7328389 mtsC Streptococcus pneumoniae ATCC 700669 metal cation ABC transporter membrane protein YP_002511541.1 1588024 D 561276 CDS YP_002511542.1 221232389 7328390 1588904..1589833 1 NC_011900.1 metal ABC transporter substrate-binding lipoprotein precursor 1589833 mtsA 7328390 mtsA Streptococcus pneumoniae ATCC 700669 metal ABC transporter substrate-binding lipoprotein precursor YP_002511542.1 1588904 D 561276 CDS YP_002511543.1 221232390 7328388 1589956..1590447 1 NC_011900.1 antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase 1590447 tpx 7328388 tpx Streptococcus pneumoniae ATCC 700669 thiol peroxidase YP_002511543.1 1589956 D 561276 CDS YP_002511544.1 221232391 7327580 complement(1590543..1593251) 1 NC_011900.1 ABC transporter permease 1593251 7327580 SPN23F_16540 Streptococcus pneumoniae ATCC 700669 ABC transporter permease YP_002511544.1 1590543 R 561276 CDS YP_002511545.1 221232392 7328837 complement(1593253..1593954) 1 NC_011900.1 ABC transporter ATP-binding protein 1593954 7328837 SPN23F_16550 Streptococcus pneumoniae ATCC 700669 ABC transporter ATP-binding protein YP_002511545.1 1593253 R 561276 CDS YP_002511546.1 221232393 7328838 complement(1594204..1596615) 1 NC_011900.1 hypothetical protein 1596615 7328838 SPN23F_16560 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511546.1 1594204 R 561276 CDS YP_002511547.1 221232394 7328839 complement(1596668..1597360) 1 NC_011900.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase 1597360 gpmA 7328839 gpmA Streptococcus pneumoniae ATCC 700669 phosphoglyceromutase YP_002511547.1 1596668 R 561276 CDS YP_002511548.1 221232395 7328619 complement(1597411..1597599) 1 NC_011900.1 hypothetical protein 1597599 7328619 SPN23F_16580 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511548.1 1597411 R 561276 CDS YP_002511549.1 221232396 7328840 complement(1597895..1598275) 1 NC_011900.1 integral membrane protein 1598275 7328840 SPN23F_16590 Streptococcus pneumoniae ATCC 700669 integral membrane protein YP_002511549.1 1597895 R 561276 CDS YP_002511550.1 221232397 7328841 complement(1598678..1601470) 1 NC_011900.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase 1601470 ileS 7328841 ileS Streptococcus pneumoniae ATCC 700669 isoleucyl-tRNA synthetase YP_002511550.1 1598678 R 561276 CDS YP_002511551.1 221232398 7329473 complement(1601818..1602606) 1 NC_011900.1 cell-division protein DivIVA 1602606 7329473 SPN23F_16620 Streptococcus pneumoniae ATCC 700669 cell-division protein DivIVA YP_002511551.1 1601818 R 561276 CDS YP_002511552.1 221232399 7328842 complement(1602615..1603400) 1 NC_011900.1 hypothetical protein 1603400 7328842 SPN23F_16630 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511552.1 1602615 R 561276 CDS YP_002511553.1 221232400 7328843 complement(1603397..1603660) 1 NC_011900.1 hypothetical protein 1603660 7328843 SPN23F_16640 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511553.1 1603397 R 561276 CDS YP_002511554.1 221232401 7328844 complement(1603660..1604199) 1 NC_011900.1 hypothetical protein 1604199 7328844 SPN23F_16650 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511554.1 1603660 R 561276 CDS YP_002511555.1 221232402 7328845 complement(1604209..1604880) 1 NC_011900.1 hypothetical protein 1604880 7328845 SPN23F_16660 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511555.1 1604209 R 561276 CDS YP_002511556.1 221232403 7328846 complement(1604885..1606144) 1 NC_011900.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 1606144 ftsZ 7328846 ftsZ Streptococcus pneumoniae ATCC 700669 cell division protein FtsZ YP_002511556.1 1604885 R 561276 CDS YP_002511557.1 221232404 7328574 complement(1606161..1607534) 1 NC_011900.1 cell division protein 1607534 ftsA 7328574 ftsA Streptococcus pneumoniae ATCC 700669 cell division protein YP_002511557.1 1606161 R 561276 CDS YP_002511558.1 221232405 7328567 complement(1607753..1608457) 1 NC_011900.1 hypothetical protein 1608457 7328567 SPN23F_16690 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511558.1 1607753 R 561276 CDS YP_002511559.1 221232406 7328847 complement(1608548..1609159) 1 NC_011900.1 MutT/NUDIX hydrolase family protein 1609159 7328847 SPN23F_16700 Streptococcus pneumoniae ATCC 700669 MutT/NUDIX hydrolase family protein YP_002511559.1 1608548 R 561276 CDS YP_002511560.1 221232407 7328848 complement(1609146..1610519) 1 NC_011900.1 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase 1610519 murF 7328848 murF Streptococcus pneumoniae ATCC 700669 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase YP_002511560.1 1609146 R 561276 CDS YP_002511561.1 221232408 7328396 complement(1610603..1611646) 1 NC_011900.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A 1611646 ddl 7328396 ddl Streptococcus pneumoniae ATCC 700669 D-alanyl-alanine synthetase A YP_002511561.1 1610603 R 561276 CDS YP_002511562.1 221232409 7329223 complement(1611822..1612418) 1 NC_011900.1 involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 1612418 recR 7329223 recR Streptococcus pneumoniae ATCC 700669 recombination protein RecR YP_002511562.1 1611822 R 561276 CDS YP_002511563.1 221232410 7327447 complement(1612429..1614471) 1 NC_011900.1 penicillin-binding protein 2b 1614471 penA 7327447 penA Streptococcus pneumoniae ATCC 700669 penicillin-binding protein 2b YP_002511563.1 1612429 R 561276 CDS YP_002511564.1 221232411 7327822 1614680..1615531 1 NC_011900.1 transcription regulator 1615531 7327822 SPN23F_16750 Streptococcus pneumoniae ATCC 700669 transcription regulator YP_002511564.1 1614680 D 561276 CDS YP_002511565.1 221232412 7328849 complement(1615547..1616431) 1 NC_011900.1 ROK family protein 1616431 7328849 SPN23F_16760 Streptococcus pneumoniae ATCC 700669 ROK family protein YP_002511565.1 1615547 R 561276 CDS YP_002511566.1 221232413 7328850 complement(1616449..1617366) 1 NC_011900.1 N-acetylneuraminate lyase 1617366 nanH 7328850 nanH Streptococcus pneumoniae ATCC 700669 N-acetylneuraminate lyase YP_002511566.1 1616449 R 561276 CDS YP_002511567.1 221232414 7328418 complement(1617535..1618179) 1 NC_011900.1 hypothetical protein 1618179 7328418 SPN23F_16780 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511567.1 1617535 R 561276 CDS YP_002511568.1 221232415 7328851 complement(1618466..1618810) 1 NC_011900.1 hypothetical protein 1618810 7328851 SPN23F_16790 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511568.1 1618466 R 561276 CDS YP_002511569.1 221232416 7328852 complement(1618907..1619359) 1 NC_011900.1 hypothetical protein 1619359 7328852 SPN23F_16800 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511569.1 1618907 R 561276 CDS YP_002511570.1 221232417 7328853 complement(1619631..1620470) 1 NC_011900.1 transport system permease 1620470 7328853 SPN23F_16810 Streptococcus pneumoniae ATCC 700669 transport system permease YP_002511570.1 1619631 R 561276 CDS YP_002511571.1 221232418 7328854 complement(1620486..1621382) 1 NC_011900.1 transport system permease 1621382 7328854 SPN23F_16820 Streptococcus pneumoniae ATCC 700669 transport system permease YP_002511571.1 1620486 R 561276 CDS YP_002511572.1 221232419 7328855 complement(1621605..1622933) 1 NC_011900.1 extracellular solute-binding lipoprotein 1622933 7328855 SPN23F_16830 Streptococcus pneumoniae ATCC 700669 extracellular solute-binding lipoprotein YP_002511572.1 1621605 R 561276 CDS YP_002511573.1 221232420 7328856 complement(1623058..1624575) 1 NC_011900.1 sugar phosphotransferase system (PTS), IIBC component 1624575 7328856 SPN23F_16840 Streptococcus pneumoniae ATCC 700669 sugar phosphotransferase system (PTS), IIBC component YP_002511573.1 1623058 R 561276 CDS YP_002511574.1 221232421 7328857 complement(1624594..1625292) 1 NC_011900.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase 1625292 7328857 SPN23F_16850 Streptococcus pneumoniae ATCC 700669 N-acetylmannosamine-6-phosphate 2-epimerase YP_002511574.1 1624594 R 561276 CDS YP_002511575.1 221232422 7328858 complement(1625466..1626569) 1 NC_011900.1 oxidoreductase 1626569 7328858 SPN23F_16860 Streptococcus pneumoniae ATCC 700669 oxidoreductase YP_002511575.1 1625466 R 561276 CDS YP_002511576.1 221232423 7328859 complement(1626581..1628674) 1 NC_011900.1 sialidase B precursor (neuraminidase B) 1628674 nanB 7328859 nanB Streptococcus pneumoniae ATCC 700669 sialidase B precursor (neuraminidase B) YP_002511576.1 1626581 R 561276 CDS YP_002511577.1 221232424 7328416 complement(1628692..1629525) 1 NC_011900.1 ABC transporter permease 1629525 7328416 SPN23F_16880 Streptococcus pneumoniae ATCC 700669 ABC transporter permease YP_002511577.1 1628692 R 561276 CDS YP_002511578.1 221232425 7328860 complement(1629525..1630409) 1 NC_011900.1 ABC transporter permease 1630409 7328860 SPN23F_16890 Streptococcus pneumoniae ATCC 700669 ABC transporter permease YP_002511578.1 1629525 R 561276 CDS YP_002511579.1 221232426 7328060 complement(1630488..1631825) 1 NC_011900.1 ABC transporter substrate-binding protein 1631825 7328060 SPN23F_16900 Streptococcus pneumoniae ATCC 700669 ABC transporter substrate-binding protein YP_002511579.1 1630488 R 561276 CDS YP_002511580.1 221232427 7329488 complement(1631844..1632296) 1 NC_011900.1 hypothetical protein 1632296 7329488 SPN23F_16910 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511580.1 1631844 R 561276 CDS YP_002511581.1 221232428 7329489 complement(1633310..1636207) 1 NC_011900.1 sialidase A (neuraminidase A) 1636207 nanA 7329489 nanA Streptococcus pneumoniae ATCC 700669 sialidase A (neuraminidase A) YP_002511581.1 1633310 R 561276 CDS YP_002511582.1 221232429 7328415 complement(1636495..1636722) 1 NC_011900.1 hypothetical protein 1636722 7328415 SPN23F_16930 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511582.1 1636495 R 561276 CDS YP_002511583.1 221232430 7329490 complement(1637752..1638732) 1 NC_011900.1 acetyl xylan esterase (AXE1) family protein 1638732 7329490 SPN23F_16950 Streptococcus pneumoniae ATCC 700669 acetyl xylan esterase (AXE1) family protein YP_002511583.1 1637752 R 561276 CDS YP_002511584.1 221232431 7329491 complement(1639049..1641064) 1 NC_011900.1 catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG 1641064 recG 7329491 recG Streptococcus pneumoniae ATCC 700669 ATP-dependent DNA helicase RecG YP_002511584.1 1639049 R 561276 CDS YP_002511585.1 221232432 7327444 complement(1641083..1642186) 1 NC_011900.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase 1642186 alr 7327444 alr Streptococcus pneumoniae ATCC 700669 alanine racemase YP_002511585.1 1641083 R 561276 CDS YP_002511586.1 221232433 7328648 complement(1642176..1642538) 1 NC_011900.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase 1642538 acpS 7328648 acpS Streptococcus pneumoniae ATCC 700669 4'-phosphopantetheinyl transferase YP_002511586.1 1642176 R 561276 CDS YP_002511587.1 221232434 7328632 complement(1642583..1643614) 1 NC_011900.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 1643614 aroF 7328632 aroF Streptococcus pneumoniae ATCC 700669 phospho-2-dehydro-3-deoxyheptonate aldolase YP_002511587.1 1642583 R 561276 CDS YP_002511588.1 221232435 7328663 complement(1643616..1644647) 1 NC_011900.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 1644647 aroF1 7328663 aroF1 Streptococcus pneumoniae ATCC 700669 phospho-2-dehydro-3-deoxyheptonate aldolase YP_002511588.1 1643616 R 561276 CDS YP_002511589.1 221232436 7328664 complement(1644728..1647241) 1 NC_011900.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 1647241 secA 7328664 secA Streptococcus pneumoniae ATCC 700669 preprotein translocase subunit SecA YP_002511589.1 1644728 R 561276 CDS YP_002511590.1 221232437 7329140 complement(1647387..1647674) 1 NC_011900.1 hypothetical protein 1647674 7329140 SPN23F_17020 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511590.1 1647387 R 561276 CDS YP_002511591.1 221232438 7329492 complement(1647702..1648334) 1 NC_011900.1 ABC transporter ATP-binding protein 1648334 7329492 SPN23F_17030 Streptococcus pneumoniae ATCC 700669 ABC transporter ATP-binding protein YP_002511591.1 1647702 R 561276 CDS YP_002511592.1 221232439 7329493 complement(1648338..1648979) 1 NC_011900.1 hypothetical protein 1648979 7329493 SPN23F_17040 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511592.1 1648338 R 561276 CDS YP_002511593.1 221232440 7329494 complement(1648972..1649763) 1 NC_011900.1 hypothetical protein 1649763 7329494 SPN23F_17050 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511593.1 1648972 R 561276 CDS YP_002511594.1 221232441 7329495 complement(1649785..1650177) 1 NC_011900.1 hypothetical protein 1650177 7329495 SPN23F_17060 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511594.1 1649785 R 561276 CDS YP_002511595.1 221232442 7329496 1650504..1651355 1 NC_011900.1 DNA-binding protein 1651355 7329496 SPN23F_17070 Streptococcus pneumoniae ATCC 700669 DNA-binding protein YP_002511595.1 1650504 D 561276 CDS YP_002511596.1 221232443 7329497 complement(1651587..1651937) 1 NC_011900.1 hypothetical protein 1651937 7329497 SPN23F_17080 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511596.1 1651587 R 561276 CDS YP_002511597.1 221232444 7329498 complement(1652077..1652412) 1 NC_011900.1 hypothetical protein 1652412 7329498 SPN23F_17090 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511597.1 1652077 R 561276 CDS YP_002511598.1 221232445 7329499 complement(1652500..1653810) 1 NC_011900.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 1653810 engA 7329499 engA Streptococcus pneumoniae ATCC 700669 GTP-binding protein EngA YP_002511598.1 1652500 R 561276 CDS YP_002511599.1 221232446 7329253 complement(1653824..1654537) 1 NC_011900.1 oxygen-insensitive NADPH nitroreductase 1654537 nfsA 7329253 nfsA Streptococcus pneumoniae ATCC 700669 oxygen-insensitive NADPH nitroreductase YP_002511599.1 1653824 R 561276 CDS YP_002511600.1 221232447 7328420 complement(1654534..1655430) 1 NC_011900.1 Primosomal protein that may act to load helicase DnaC during DNA replication; primosomal protein DnaI 1655430 dnaI 7328420 dnaI Streptococcus pneumoniae ATCC 700669 primosomal protein DnaI YP_002511600.1 1654534 R 561276 CDS YP_002511601.1 221232448 7329243 complement(1655431..1656600) 1 NC_011900.1 replication initiation and membrane attachment protein 1656600 dnaB 7329243 dnaB Streptococcus pneumoniae ATCC 700669 replication initiation and membrane attachment protein YP_002511601.1 1655431 R 561276 CDS YP_002511602.1 221232449 7329238 complement(1656601..1657074) 1 NC_011900.1 NrdR family transcriptional regulator 1657074 nrdR 7329238 nrdR Streptococcus pneumoniae ATCC 700669 NrdR family transcriptional regulator YP_002511602.1 1656601 R 561276 CDS YP_002511603.1 221232450 7329500 1657214..1657579 1 NC_011900.1 GntR family transcriptional regulator 1657579 7329500 SPN23F_17150 Streptococcus pneumoniae ATCC 700669 GntR family transcriptional regulator YP_002511603.1 1657214 D 561276 CDS YP_002511604.1 221232451 7329501 1657584..1658279 1 NC_011900.1 ABC transporter ATP-binding protein 1658279 7329501 SPN23F_17160 Streptococcus pneumoniae ATCC 700669 ABC transporter ATP-binding protein YP_002511604.1 1657584 D 561276 CDS YP_002511605.1 221232452 7329502 1658296..1659063 1 NC_011900.1 hypothetical protein 1659063 7329502 SPN23F_17170 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511605.1 1658296 D 561276 CDS YP_002511606.1 221232453 7329503 complement(1659416..1660615) 1 NC_011900.1 hypothetical protein 1660615 7329503 SPN23F_17180 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511606.1 1659416 R 561276 CDS YP_002511607.1 221232454 7329504 complement(1660612..1661505) 1 NC_011900.1 ABC transporter ATP-binding protein 1661505 7329504 SPN23F_17190 Streptococcus pneumoniae ATCC 700669 ABC transporter ATP-binding protein YP_002511607.1 1660612 R 561276 CDS YP_002511608.1 221232455 7329505 1662815..1663432 1 NC_011900.1 hypothetical protein 1663432 7329505 SPN23F_17210 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511608.1 1662815 D 561276 CDS YP_002511609.1 221232456 7329506 complement(1663752..1664639) 1 NC_011900.1 fructokinase 1664639 scrK 7329506 scrK Streptococcus pneumoniae ATCC 700669 fructokinase YP_002511609.1 1663752 R 561276 CDS YP_002511610.1 221232457 7329136 complement(1664788..1666671) 1 NC_011900.1 sucrose-specific phosphotransferase system (PTS), IIABC component 1666671 scrA 7329136 scrA Streptococcus pneumoniae ATCC 700669 sucrose-specific phosphotransferase system (PTS), IIABC component YP_002511610.1 1664788 R 561276 CDS YP_002511611.1 221232458 7329134 1667048..1668502 1 NC_011900.1 sucrose-6-phosphate hydrolase 1668502 scrB 7329134 scrB Streptococcus pneumoniae ATCC 700669 sucrose-6-phosphate hydrolase YP_002511611.1 1667048 D 561276 CDS YP_002511612.1 221232459 7329135 1668483..1669448 1 NC_011900.1 sucrose operon repressor 1669448 scrR 7329135 scrR Streptococcus pneumoniae ATCC 700669 sucrose operon repressor YP_002511612.1 1668483 D 561276 CDS YP_002511613.1 221232460 7329137 complement(1669483..1670757) 1 NC_011900.1 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1670757 mvaA 7329137 mvaA Streptococcus pneumoniae ATCC 700669 3-hydroxy-3-methylglutaryl-coenzyme A reductase YP_002511613.1 1669483 R 561276 CDS YP_002511614.1 221232461 7328406 complement(1670757..1671929) 1 NC_011900.1 3-hydroxy-3-methylglutaryl coenzyme A synthase 1671929 mvaS 7328406 mvaS Streptococcus pneumoniae ATCC 700669 3-hydroxy-3-methylglutaryl coenzyme A synthase YP_002511614.1 1670757 R 561276 CDS YP_002511615.1 221232462 7328410 complement(1672060..1672308) 1 NC_011900.1 hypothetical protein 1672308 7328410 SPN23F_17290 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511615.1 1672060 R 561276 CDS YP_002511616.1 221232463 7329508 complement(1673063..1673398) 1 NC_011900.1 hypothetical protein 1673398 7329508 SPN23F_17330 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511616.1 1673063 R 561276 CDS YP_002511617.1 221232464 7329509 complement(1673514..1674272) 1 NC_011900.1 hypothetical protein 1674272 7329509 SPN23F_17340 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511617.1 1673514 R 561276 CDS YP_002511618.1 221232465 7329510 complement(1674387..1676366) 1 NC_011900.1 serine/threonine-protein kinase 1676366 stk1 7329510 stk1 Streptococcus pneumoniae ATCC 700669 serine/threonine-protein kinase YP_002511618.1 1674387 R 561276 CDS YP_002511619.1 221232466 7329157 complement(1676363..1677103) 1 NC_011900.1 protein phosphatase 1677103 7329157 SPN23F_17360 Streptococcus pneumoniae ATCC 700669 protein phosphatase YP_002511619.1 1676363 R 561276 CDS YP_002511620.1 221232467 7329511 complement(1677118..1678431) 1 NC_011900.1 ribosomal RNA small subunit methyltransferase 1678431 7329511 SPN23F_17370 Streptococcus pneumoniae ATCC 700669 ribosomal RNA small subunit methyltransferase YP_002511620.1 1677118 R 561276 CDS YP_002511621.1 221232468 7329512 complement(1678424..1679359) 1 NC_011900.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase 1679359 fmt 7329512 fmt Streptococcus pneumoniae ATCC 700669 methionyl-tRNA formyltransferase YP_002511621.1 1678424 R 561276 CDS YP_002511622.1 221232469 7328556 complement(1679372..1681768) 1 NC_011900.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA 1681768 priA 7328556 priA Streptococcus pneumoniae ATCC 700669 primosome assembly protein PriA YP_002511622.1 1679372 R 561276 CDS YP_002511623.1 221232470 7327875 complement(1681834..1682148) 1 NC_011900.1 Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 1682148 rpoZ 7327875 rpoZ Streptococcus pneumoniae ATCC 700669 DNA-directed RNA polymerase subunit omega YP_002511623.1 1681834 R 561276 CDS YP_002511624.1 221232471 7329108 complement(1682173..1682799) 1 NC_011900.1 Essential for recycling GMP and indirectly, cGMP; guanylate kinase 1682799 gmk 7329108 gmk Streptococcus pneumoniae ATCC 700669 guanylate kinase YP_002511624.1 1682173 R 561276 CDS YP_002511625.1 221232472 7328616 complement(1682929..1684542) 1 NC_011900.1 hypothetical protein 1684542 7328616 SPN23F_17420 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511625.1 1682929 R 561276 CDS YP_002511626.1 221232473 7329513 complement(1684612..1684902) 1 NC_011900.1 site-specific recombinase 1684902 7329513 SPN23F_17430 Streptococcus pneumoniae ATCC 700669 site-specific recombinase YP_002511626.1 1684612 R 561276 CDS YP_002511627.1 221232474 7329514 complement(1685025..1685783) 1 NC_011900.1 Unique to this genome and apparently part of an integrated element.; hypothetical protein 1685783 7329514 SPN23F_17440 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511627.1 1685025 R 561276 CDS YP_002511628.1 221232475 7329515 complement(1685799..1685939) 1 NC_011900.1 May form N-term signal sequence for downstream gene?; hypothetical protein 1685939 7329515 SPN23F_17450 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511628.1 1685799 R 561276 CDS YP_002511629.1 221232476 7329516 complement(1686091..1686264) 1 NC_011900.1 hypothetical protein 1686264 7329516 SPN23F_17460 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511629.1 1686091 R 561276 CDS YP_002511630.1 221232477 7329519 complement(1687632..1688729) 1 NC_011900.1 hypothetical protein 1688729 7329519 SPN23F_17490 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511630.1 1687632 R 561276 CDS YP_002511631.1 221232478 7329520 complement(1688739..1689479) 1 NC_011900.1 methyltransferase 1689479 7329520 SPN23F_17500 Streptococcus pneumoniae ATCC 700669 methyltransferase YP_002511631.1 1688739 R 561276 CDS YP_002511632.1 221232479 7329521 complement(1689799..1690152) 1 NC_011900.1 hypothetical protein 1690152 7329521 SPN23F_17510 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511632.1 1689799 R 561276 CDS YP_002511633.1 221232480 7329522 complement(1690165..1690665) 1 NC_011900.1 isochorismatase 1690665 7329522 SPN23F_17520 Streptococcus pneumoniae ATCC 700669 isochorismatase YP_002511633.1 1690165 R 561276 CDS YP_002511634.1 221232481 7329523 complement(1690666..1691259) 1 NC_011900.1 hypothetical protein 1691259 7329523 SPN23F_17530 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511634.1 1690666 R 561276 CDS YP_002511635.1 221232482 7329524 complement(1691259..1691888) 1 NC_011900.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase 1691888 nadD 7329524 nadD Streptococcus pneumoniae ATCC 700669 nicotinic acid mononucleotide adenylyltransferase YP_002511635.1 1691259 R 561276 CDS YP_002511636.1 221232483 7329525 complement(1691940..1692251) 1 NC_011900.1 hypothetical protein 1692251 7329525 SPN23F_17550 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511636.1 1691940 R 561276 CDS YP_002511637.1 221232484 7329526 complement(1692451..1693557) 1 NC_011900.1 in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis; GTP-binding protein YqeH 1693557 7329526 SPN23F_17560 Streptococcus pneumoniae ATCC 700669 GTP-binding protein YqeH YP_002511637.1 1692451 R 561276 CDS YP_002511638.1 221232485 7329527 complement(1693560..1694087) 1 NC_011900.1 hydrolase 1694087 7329527 SPN23F_17570 Streptococcus pneumoniae ATCC 700669 hydrolase YP_002511638.1 1693560 R 561276 CDS YP_002511639.1 221232486 7329528 complement(1694102..1695010) 1 NC_011900.1 CorA-like Mg2+ transporter protein 1695010 7329528 SPN23F_17580 Streptococcus pneumoniae ATCC 700669 CorA-like Mg2+ transporter protein YP_002511639.1 1694102 R 561276 CDS YP_002511640.1 221232487 7329529 complement(1695067..1695627) 1 NC_011900.1 mechanosensitive ion channel protein 1695627 7329529 SPN23F_17590 Streptococcus pneumoniae ATCC 700669 mechanosensitive ion channel protein YP_002511640.1 1695067 R 561276 CDS YP_002511641.1 221232488 7329530 1695831..1696019 1 NC_011900.1 sodium:dicarboxylate symporter family protein 1696019 7329530 SPN23F_17600 Streptococcus pneumoniae ATCC 700669 sodium:dicarboxylate symporter family protein YP_002511641.1 1695831 D 561276 CDS YP_002511642.1 221232489 7329531 1696016..1696975 1 NC_011900.1 involved in the import of serine and threonine coupled with the import of sodium; serine/threonine transporter SstT 1696975 7329531 SPN23F_17610 Streptococcus pneumoniae ATCC 700669 serine/threonine transporter SstT YP_002511642.1 1696016 D 561276 CDS YP_002511643.1 221232490 7329532 1697043..1697996 1 NC_011900.1 hypothetical protein 1697996 7329532 SPN23F_17620 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511643.1 1697043 D 561276 CDS YP_002511644.1 221232491 7329533 complement(1698019..1698621) 1 NC_011900.1 Mostly made up of 11 x FEVVDRTDEVSSKHR tandem repeat. No good RBS.; hypothetical protein 1698621 7329533 SPN23F_17630 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511644.1 1698019 R 561276 CDS YP_002511645.1 221232492 7329534 complement(1698682..1698906) 1 NC_011900.1 hypothetical protein 1698906 7329534 SPN23F_17640 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511645.1 1698682 R 561276 CDS YP_002511646.1 221232493 7329535 complement(1698911..1699090) 1 NC_011900.1 hypothetical protein 1699090 7329535 SPN23F_17650 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511646.1 1698911 R 561276 CDS YP_002511647.1 221232494 7329536 complement(1699092..1700429) 1 NC_011900.1 hypothetical protein 1700429 7329536 SPN23F_17660 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511647.1 1699092 R 561276 CDS YP_002511648.1 221232495 7329537 complement(1700422..1701933) 1 NC_011900.1 glycosyl transferase 1701933 7329537 SPN23F_17670 Streptococcus pneumoniae ATCC 700669 glycosyl transferase YP_002511648.1 1700422 R 561276 CDS YP_002511649.1 221232496 7329538 complement(1701945..1704317) 1 NC_011900.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; in some organisms, especially gram positive pathogens, have paralogs that have been found to be nonessential but do function in secretion of a subset of exported proteins; preprotein translocase subunit SecA 1704317 7329538 SPN23F_17680 Streptococcus pneumoniae ATCC 700669 preprotein translocase subunit SecA YP_002511649.1 1701945 R 561276 CDS YP_002511650.1 221232497 7329539 complement(1704310..1704750) 1 NC_011900.1 hypothetical protein 1704750 7329539 SPN23F_17690 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511650.1 1704310 R 561276 CDS YP_002511651.1 221232498 7329540 complement(1704747..1706282) 1 NC_011900.1 hypothetical protein 1706282 7329540 SPN23F_17700 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511651.1 1704747 R 561276 CDS YP_002511652.1 221232499 7329541 complement(1706266..1707846) 1 NC_011900.1 hypothetical protein 1707846 7329541 SPN23F_17710 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511652.1 1706266 R 561276 CDS YP_002511653.1 221232500 7329542 complement(1707856..1709073) 1 NC_011900.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 1709073 secY 7329542 secY Streptococcus pneumoniae ATCC 700669 preprotein translocase subunit SecY YP_002511653.1 1707856 R 561276 CDS YP_002511654.1 221232501 7329543 complement(1709130..1710035) 1 NC_011900.1 glycosyltransferase 1710035 7329543 SPN23F_17730 Streptococcus pneumoniae ATCC 700669 glycosyltransferase YP_002511654.1 1709130 R 561276 CDS YP_002511655.1 221232502 7329544 complement(1710035..1711231) 1 NC_011900.1 glycosyltransferase 1711231 7329544 SPN23F_17740 Streptococcus pneumoniae ATCC 700669 glycosyltransferase YP_002511655.1 1710035 R 561276 CDS YP_002511656.1 221232503 7329545 complement(1711240..1712460) 1 NC_011900.1 glycosyltransferase 1712460 7329545 SPN23F_17750 Streptococcus pneumoniae ATCC 700669 glycosyltransferase YP_002511656.1 1711240 R 561276 CDS YP_002511657.1 221232504 7329546 complement(1712485..1713369) 1 NC_011900.1 glycosyl transferase 1713369 7329546 SPN23F_17760 Streptococcus pneumoniae ATCC 700669 glycosyl transferase YP_002511657.1 1712485 R 561276 CDS YP_002511658.1 221232505 7329547 complement(1713366..1715819) 1 NC_011900.1 glycosyltransferase 1715819 7329547 SPN23F_17770 Streptococcus pneumoniae ATCC 700669 glycosyltransferase YP_002511658.1 1713366 R 561276 CDS YP_002511659.1 221232506 7329548 complement(1715902..1716867) 1 NC_011900.1 hypothetical protein 1716867 7329548 SPN23F_17780 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511659.1 1715902 R 561276 CDS YP_002511660.1 221232507 7329549 complement(1716896..1717486) 1 NC_011900.1 glycosyltransferase 1717486 7329549 SPN23F_17790 Streptococcus pneumoniae ATCC 700669 glycosyltransferase YP_002511660.1 1716896 R 561276 CDS YP_002511661.1 221232508 7329550 complement(1717777..1718991) 1 NC_011900.1 glycosyltransferase 1718991 7329550 SPN23F_17800 Streptococcus pneumoniae ATCC 700669 glycosyltransferase YP_002511661.1 1717777 R 561276 CDS YP_002511662.1 221232509 7329551 complement(1719298..1721382) 1 NC_011900.1 glycosyl transferase 1721382 7329551 SPN23F_17810 Streptococcus pneumoniae ATCC 700669 glycosyl transferase YP_002511662.1 1719298 R 561276 CDS YP_002511663.1 221232510 7329552 complement(1721443..1734744) 1 NC_011900.1 cell wall surface anchored protein 1734744 psrP 7329552 psrP Streptococcus pneumoniae ATCC 700669 cell wall surface anchored protein YP_002511663.1 1721443 R 561276 CDS YP_002511664.1 221232511 7327884 complement(1735116..1735595) 1 NC_011900.1 match to Transposase_14 (PF01710); transposase 1735595 7327884 SPN23F_17840 Streptococcus pneumoniae ATCC 700669 transposase YP_002511664.1 1735116 R 561276 CDS YP_002511665.1 221232512 7329553 1735974..1736354 1 NC_011900.1 match to MarR (PF01047); MarR-family transcriptional regulator 1736354 7329553 SPN23F_17850 Streptococcus pneumoniae ATCC 700669 MarR-family transcriptional regulator YP_002511665.1 1735974 D 561276 CDS YP_002511666.1 221232513 7329554 1736453..1736674 1 NC_011900.1 hypothetical protein 1736674 7329554 SPN23F_17860 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511666.1 1736453 D 561276 CDS YP_002511667.1 221232514 7329555 1736691..1737005 1 NC_011900.1 thioredoxin 1737005 7329555 SPN23F_17870 Streptococcus pneumoniae ATCC 700669 thioredoxin YP_002511667.1 1736691 D 561276 CDS YP_002511668.1 221232515 7329556 1737312..1737845 1 NC_011900.1 NADPH-dependent; catalyzes the reduction of 7-cyano-7-deazaguanine to 7-aminomethyl-7-deazaguanine in queuosine biosynthesis; 7-cyano-7-deazaguanine reductase 1737845 7329556 SPN23F_17880 Streptococcus pneumoniae ATCC 700669 7-cyano-7-deazaguanine reductase YP_002511668.1 1737312 D 561276 CDS YP_002511669.1 221232516 7329557 1737907..1738164 1 NC_011900.1 hypothetical protein 1738164 7329557 SPN23F_17890 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511669.1 1737907 D 561276 CDS YP_002511670.1 221232517 7329558 complement(1738189..1738857) 1 NC_011900.1 aquaporin Z 1738857 aqpZ 7329558 aqpZ Streptococcus pneumoniae ATCC 700669 aquaporin Z YP_002511670.1 1738189 R 561276 CDS YP_002511671.1 221232518 7328651 complement(1738968..1739759) 1 NC_011900.1 hypothetical protein 1739759 7328651 SPN23F_17910 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511671.1 1738968 R 561276 CDS YP_002511672.1 221232519 7329559 complement(1739827..1739982) 1 NC_011900.1 hypothetical protein 1739982 7329559 SPN23F_17920 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511672.1 1739827 R 561276 CDS YP_002511673.1 221232520 7329560 complement(1740006..1741802) 1 NC_011900.1 oligopeptidase 1741802 7329560 SPN23F_17930 Streptococcus pneumoniae ATCC 700669 oligopeptidase YP_002511673.1 1740006 R 561276 CDS YP_002511674.1 221232521 7329561 complement(1741813..1742556) 1 NC_011900.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 1742556 7329561 SPN23F_17940 Streptococcus pneumoniae ATCC 700669 16S ribosomal RNA methyltransferase RsmE YP_002511674.1 1741813 R 561276 CDS YP_002511675.1 221232522 7329562 complement(1742558..1743508) 1 NC_011900.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; ribosomal protein L11 methyltransferase 1743508 prmA 7329562 prmA Streptococcus pneumoniae ATCC 700669 ribosomal protein L11 methyltransferase YP_002511675.1 1742558 R 561276 CDS YP_002511676.1 221232523 7329563 complement(1743523..1744539) 1 NC_011900.1 otitis media-associated p41 1744539 7329563 SPN23F_17960 Streptococcus pneumoniae ATCC 700669 otitis media-associated p41 YP_002511676.1 1743523 R 561276 CDS YP_002511677.1 221232524 7329564 complement(1744590..1746734) 1 NC_011900.1 hypothetical protein 1746734 7329564 SPN23F_17970 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511677.1 1744590 R 561276 CDS YP_002511678.1 221232525 7329565 complement(1746835..1747869) 1 NC_011900.1 ATPase 1747869 7329565 SPN23F_17980 Streptococcus pneumoniae ATCC 700669 ATPase YP_002511678.1 1746835 R 561276 CDS YP_002511679.1 221232526 7329566 complement(1748118..1749206) 1 NC_011900.1 peptidase 1749206 7329566 SPN23F_18000 Streptococcus pneumoniae ATCC 700669 peptidase YP_002511679.1 1748118 R 561276 CDS YP_002511680.1 221232527 7328141 complement(1749225..1749695) 1 NC_011900.1 hypothetical protein 1749695 7328141 SPN23F_18010 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511680.1 1749225 R 561276 CDS YP_002511681.1 221232528 7329341 complement(1749986..1750438) 1 NC_011900.1 phage-like protein 1750438 7329341 SPN23F_18020 Streptococcus pneumoniae ATCC 700669 phage-like protein YP_002511681.1 1749986 R 561276 CDS YP_002511682.1 221232529 7329342 complement(1750791..1750970) 1 NC_011900.1 hypothetical protein 1750970 7329342 SPN23F_18030 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511682.1 1750791 R 561276 CDS YP_002511683.1 221232530 7329343 complement(1751135..1751374) 1 NC_011900.1 hypothetical protein 1751374 7329343 SPN23F_18040 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511683.1 1751135 R 561276 CDS YP_002511684.1 221232531 7329344 1751644..1752915 1 NC_011900.1 recombination factor protein RarA 1752915 7329344 SPN23F_18050 Streptococcus pneumoniae ATCC 700669 recombination factor protein RarA YP_002511684.1 1751644 D 561276 CDS YP_002511685.1 221232532 7327621 complement(1753460..1754779) 1 NC_011900.1 beta-fructofuranosidase 1754779 7327621 SPN23F_18060 Streptococcus pneumoniae ATCC 700669 beta-fructofuranosidase YP_002511685.1 1753460 R 561276 CDS YP_002511686.1 221232533 7329346 complement(1754789..1756405) 1 NC_011900.1 extracellular solute-binding protein 1756405 7329346 SPN23F_18070 Streptococcus pneumoniae ATCC 700669 extracellular solute-binding protein YP_002511686.1 1754789 R 561276 CDS YP_002511687.1 221232534 7329347 complement(1756434..1757324) 1 NC_011900.1 binding-protein-dependent transport system membrane protein 1757324 7329347 SPN23F_18080 Streptococcus pneumoniae ATCC 700669 binding-protein-dependent transport system membrane protein YP_002511687.1 1756434 R 561276 CDS YP_002511688.1 221232535 7329348 complement(1757335..1758252) 1 NC_011900.1 binding-protein-dependent transport system membrane protein 1758252 7329348 SPN23F_18090 Streptococcus pneumoniae ATCC 700669 binding-protein-dependent transport system membrane protein YP_002511688.1 1757335 R 561276 CDS YP_002511689.1 221232536 7329349 complement(1758403..1759404) 1 NC_011900.1 LacI family transcriptional regulator 1759404 7329349 SPN23F_18100 Streptococcus pneumoniae ATCC 700669 LacI family transcriptional regulator YP_002511689.1 1758403 R 561276 CDS YP_002511690.1 221232537 7329350 complement(1759766..1761247) 1 NC_011900.1 Mga-like regulatory protein 1761247 7329350 SPN23F_18110 Streptococcus pneumoniae ATCC 700669 Mga-like regulatory protein YP_002511690.1 1759766 R 561276 CDS YP_002511691.1 221232538 7329351 1761690..1761854 1 NC_011900.1 transglycosylase 1761854 7329351 SPN23F_18120 Streptococcus pneumoniae ATCC 700669 transglycosylase YP_002511691.1 1761690 D 561276 CDS YP_002511692.1 221232539 7329352 1761938..1762504 1 NC_011900.1 hypothetical protein 1762504 7329352 SPN23F_18130 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511692.1 1761938 D 561276 CDS YP_002511693.1 221232540 7329353 1762516..1762686 1 NC_011900.1 hypothetical protein 1762686 7329353 SPN23F_18140 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511693.1 1762516 D 561276 CDS YP_002511694.1 221232541 7329354 1762725..1763333 1 NC_011900.1 hypothetical protein 1763333 7329354 SPN23F_18150 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511694.1 1762725 D 561276 CDS YP_002511696.1 221232542 7329356 complement(1764824..1765594) 1 NC_011900.1 hypothetical protein 1765594 7329356 SPN23F_18180 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511696.1 1764824 R 561276 CDS YP_002511697.1 221232543 7329357 complement(1765609..1766457) 1 NC_011900.1 hypothetical protein 1766457 7329357 SPN23F_18190 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511697.1 1765609 R 561276 CDS YP_002511698.1 221232544 7329358 complement(1766454..1767929) 1 NC_011900.1 can hydrolyze p-nitrophenyl sulfate; contains a specific cysteine that is converted into C{alpha]-formylglycine upon activation with the anaerobic sulfatase-maturase; arylsulfatase 1767929 7329358 SPN23F_18200 Streptococcus pneumoniae ATCC 700669 arylsulfatase YP_002511698.1 1766454 R 561276 CDS YP_002511699.1 221232545 7329359 complement(1768252..1769607) 1 NC_011900.1 sugar phosphotransferase system (PTS), IIC component 1769607 7329359 SPN23F_18210 Streptococcus pneumoniae ATCC 700669 sugar phosphotransferase system (PTS), IIC component YP_002511699.1 1768252 R 561276 CDS YP_002511700.1 221232546 7329360 complement(1769617..1769934) 1 NC_011900.1 lactose/cellobiose-specific phosphotransferase system (PTS), IIA component 1769934 7329360 SPN23F_18220 Streptococcus pneumoniae ATCC 700669 lactose/cellobiose-specific phosphotransferase system (PTS), IIA component YP_002511700.1 1769617 R 561276 CDS YP_002511701.1 221232547 7329361 complement(1769951..1770268) 1 NC_011900.1 sugar phosphotransferase system (PTS),lactose/cellobiose-specific family, IIB component 1770268 7329361 SPN23F_18230 Streptococcus pneumoniae ATCC 700669 sugar phosphotransferase system (PTS),lactose/cellobiose-specific family, IIB component YP_002511701.1 1769951 R 561276 CDS YP_002511702.1 221232548 7329362 complement(1770283..1771179) 1 NC_011900.1 hypothetical protein 1771179 7329362 SPN23F_18240 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511702.1 1770283 R 561276 CDS YP_002511703.1 221232549 7329363 complement(1771182..1772444) 1 NC_011900.1 sugar phosphotransferase system (PTS), IIC component 1772444 7329363 SPN23F_18250 Streptococcus pneumoniae ATCC 700669 sugar phosphotransferase system (PTS), IIC component YP_002511703.1 1771182 R 561276 CDS YP_002511704.1 221232550 7329364 1772724..1773902 1 NC_011900.1 ROK-family repressor protein 1773902 7329364 SPN23F_18260 Streptococcus pneumoniae ATCC 700669 ROK-family repressor protein YP_002511704.1 1772724 D 561276 CDS YP_002511705.1 221232551 7329365 complement(1774178..1774585) 1 NC_011900.1 GNAT family acetyltransferase 1774585 7329365 SPN23F_18270 Streptococcus pneumoniae ATCC 700669 GNAT family acetyltransferase YP_002511705.1 1774178 R 561276 CDS YP_002511706.1 221232552 7329366 1774655..1775314 1 NC_011900.1 type IV prepilin peptidase family protein 1775314 7329366 SPN23F_18280 Streptococcus pneumoniae ATCC 700669 type IV prepilin peptidase family protein YP_002511706.1 1774655 D 561276 CDS YP_002511707.1 221232553 7329367 complement(1775366..1776517) 1 NC_011900.1 DNA-binding protein 1776517 7329367 SPN23F_18290 Streptococcus pneumoniae ATCC 700669 DNA-binding protein YP_002511707.1 1775366 R 561276 CDS YP_002511708.1 221232554 7329368 complement(1776532..1777263) 1 NC_011900.1 hypothetical protein 1777263 7329368 SPN23F_18300 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511708.1 1776532 R 561276 CDS YP_002511709.1 221232555 7329369 complement(1777565..1778341) 1 NC_011900.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 1778341 trpA 7329369 trpA Streptococcus pneumoniae ATCC 700669 tryptophan synthase subunit alpha YP_002511709.1 1777565 R 561276 CDS YP_002511710.1 221232556 7327645 complement(1778334..1779557) 1 NC_011900.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 1779557 trpB 7327645 trpB Streptococcus pneumoniae ATCC 700669 tryptophan synthase subunit beta YP_002511710.1 1778334 R 561276 CDS YP_002511711.1 221232557 7327646 complement(1779535..1780134) 1 NC_011900.1 catalyzes the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)-anthranilate in tryptophan biosynthesis; N-(5'-phosphoribosyl)anthranilate isomerase 1780134 trpF 7327646 trpF Streptococcus pneumoniae ATCC 700669 N-(5'-phosphoribosyl)anthranilate isomerase YP_002511711.1 1779535 R 561276 CDS YP_002511712.1 221232558 7327650 complement(1780121..1780888) 1 NC_011900.1 involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water; indole-3-glycerol-phosphate synthase 1780888 trpC 7327650 trpC Streptococcus pneumoniae ATCC 700669 indole-3-glycerol-phosphate synthase YP_002511712.1 1780121 R 561276 CDS YP_002511713.1 221232559 7327647 complement(1780885..1781889) 1 NC_011900.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate; anthranilate phosphoribosyltransferase 1781889 trpD 7327647 trpD Streptococcus pneumoniae ATCC 700669 anthranilate phosphoribosyltransferase YP_002511713.1 1780885 R 561276 CDS YP_002511714.1 221232560 7327648 complement(1781900..1782466) 1 NC_011900.1 TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity; anthranilate synthase component II 1782466 trpG 7327648 trpG Streptococcus pneumoniae ATCC 700669 anthranilate synthase component II YP_002511714.1 1781900 R 561276 CDS YP_002511715.1 221232561 7327651 complement(1782463..1783824) 1 NC_011900.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I 1783824 trpE 7327651 trpE Streptococcus pneumoniae ATCC 700669 anthranilate synthase component I YP_002511715.1 1782463 R 561276 CDS YP_002511716.1 221232562 7329474 complement(1785009..1786010) 1 NC_011900.1 LacI-family transcriptional regulator (catabolite control protein) 1786010 7329474 SPN23F_18390 Streptococcus pneumoniae ATCC 700669 LacI-family transcriptional regulator (catabolite control protein) YP_002511716.1 1785009 R 561276 CDS YP_002511717.1 221232563 7329370 complement(1786118..1786486) 1 NC_011900.1 hypothetical protein 1786486 7329370 SPN23F_18400 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511717.1 1786118 R 561276 CDS YP_002511718.1 221232564 7329371 complement(1786582..1787292) 1 NC_011900.1 cation transporter 1787292 7329371 SPN23F_18410 Streptococcus pneumoniae ATCC 700669 cation transporter YP_002511718.1 1786582 R 561276 CDS YP_002511719.1 221232565 7329372 complement(1787295..1788986) 1 NC_011900.1 inner membrane component of ABC transporter 1788986 7329372 SPN23F_18420 Streptococcus pneumoniae ATCC 700669 inner membrane component of ABC transporter YP_002511719.1 1787295 R 561276 CDS YP_002511720.1 221232566 7329373 complement(1788998..1790008) 1 NC_011900.1 iron ABC transporter ATP-binding protein 1790008 7329373 SPN23F_18430 Streptococcus pneumoniae ATCC 700669 iron ABC transporter ATP-binding protein YP_002511720.1 1788998 R 561276 CDS YP_002511721.1 221232567 7329374 complement(1790112..1791179) 1 NC_011900.1 iron ABC transporter, solute-binding protein 1791179 7329374 SPN23F_18440 Streptococcus pneumoniae ATCC 700669 iron ABC transporter, solute-binding protein YP_002511721.1 1790112 R 561276 CDS YP_002511722.1 221232568 7329375 complement(1791204..1791863) 1 NC_011900.1 hypothetical protein 1791863 7329375 SPN23F_18450 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511722.1 1791204 R 561276 CDS YP_002511723.1 221232569 7329376 complement(1792073..1793053) 1 NC_011900.1 UDP-glucose 4-epimerase 1793053 galE 7329376 galE Streptococcus pneumoniae ATCC 700669 UDP-glucose 4-epimerase YP_002511723.1 1792073 R 561276 CDS YP_002511724.1 221232570 7328581 complement(1793066..1794541) 1 NC_011900.1 catalyzes the formation of alpha-D-glucose 1-phosphate and UDP-galactose from UDP-glucose and alpha-D-galactose 1-phosphate in galactose metabolism; galactose-1-phosphate uridylyltransferase 1794541 7328581 SPN23F_18470 Streptococcus pneumoniae ATCC 700669 galactose-1-phosphate uridylyltransferase YP_002511724.1 1793066 R 561276 CDS YP_002511725.1 221232571 7329377 complement(1794554..1795195) 1 NC_011900.1 phosphate transport system protein 1795195 7329377 SPN23F_18480 Streptococcus pneumoniae ATCC 700669 phosphate transport system protein YP_002511725.1 1794554 R 561276 CDS YP_002511726.1 221232572 7329378 complement(1795253..1795654) 1 NC_011900.1 hypothetical protein 1795654 7329378 SPN23F_18490 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511726.1 1795253 R 561276 CDS YP_002511727.1 221232573 7329379 complement(1795808..1796104) 1 NC_011900.1 hypothetical protein 1796104 7329379 SPN23F_18500 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511727.1 1795808 R 561276 CDS YP_002511728.1 221232574 7329380 complement(1796088..1798214) 1 NC_011900.1 sortase-sorted surface anchored protein 1798214 7329380 SPN23F_18510 Streptococcus pneumoniae ATCC 700669 sortase-sorted surface anchored protein YP_002511728.1 1796088 R 561276 CDS YP_002511729.1 221232575 7329381 complement(1799378..1800604) 1 NC_011900.1 DegT/DnrJ/EryC1/StrS family amino sugar synthetase 1800604 7329381 SPN23F_18530 Streptococcus pneumoniae ATCC 700669 DegT/DnrJ/EryC1/StrS family amino sugar synthetase YP_002511729.1 1799378 R 561276 CDS YP_002511730.1 221232576 7329382 complement(1800647..1801339) 1 NC_011900.1 sugar transferase 1801339 7329382 SPN23F_18540 Streptococcus pneumoniae ATCC 700669 sugar transferase YP_002511730.1 1800647 R 561276 CDS YP_002511731.1 221232577 7329383 complement(1801512..1803263) 1 NC_011900.1 ABC transporter ATP-binding protein/permease 1803263 7329383 SPN23F_18550 Streptococcus pneumoniae ATCC 700669 ABC transporter ATP-binding protein/permease YP_002511731.1 1801512 R 561276 CDS YP_002511732.1 221232578 7329384 complement(1803253..1804998) 1 NC_011900.1 ABC transporter ATP-binding protein/permease 1804998 7329384 SPN23F_18560 Streptococcus pneumoniae ATCC 700669 ABC transporter ATP-binding protein/permease YP_002511732.1 1803253 R 561276 CDS YP_002511733.1 221232579 7329385 complement(1805126..1805581) 1 NC_011900.1 hypothetical protein 1805581 7329385 SPN23F_18570 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511733.1 1805126 R 561276 CDS YP_002511734.1 221232580 7329386 complement(1805653..1805832) 1 NC_011900.1 hypothetical protein 1805832 7329386 SPN23F_18580 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511734.1 1805653 R 561276 CDS YP_002511735.1 221232581 7329387 complement(1805882..1806109) 1 NC_011900.1 hypothetical protein 1806109 7329387 SPN23F_18590 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511735.1 1805882 R 561276 CDS YP_002511736.1 221232582 7329388 1806243..1807070 1 NC_011900.1 exodeoxyribonuclease 1807070 exoA 7329388 exoA Streptococcus pneumoniae ATCC 700669 exodeoxyribonuclease YP_002511736.1 1806243 D 561276 CDS YP_002511737.1 221232583 7329259 1807225..1807464 1 NC_011900.1 hypothetical protein 1807464 7329259 SPN23F_18610 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511737.1 1807225 D 561276 CDS YP_002511738.1 221232584 7329475 1808342..1808923 1 NC_011900.1 Catalyzes the transfer of the phosphoribosyl moiety from 5-phospho--D-ribosyl-1-pyrophosphate (PRib-PP) to the 6-oxo-guanine and -xanthine; xanthine phosphoribosyltransferase 1808923 xpt 7329475 xpt Streptococcus pneumoniae ATCC 700669 xanthine phosphoribosyltransferase YP_002511738.1 1808342 D 561276 CDS YP_002511739.1 221232585 7329448 1808923..1810185 1 NC_011900.1 xanthine permease 1810185 pbuX 7329448 pbuX Streptococcus pneumoniae ATCC 700669 xanthine permease YP_002511739.1 1808923 D 561276 CDS YP_002511740.1 221232586 7328457 complement(1810240..1811730) 1 NC_011900.1 restriction enzyme 1811730 7328457 SPN23F_18640 Streptococcus pneumoniae ATCC 700669 restriction enzyme YP_002511740.1 1810240 R 561276 CDS YP_002511741.1 221232587 7329390 1811847..1813112 1 NC_011900.1 DNA modification methylase 1813112 7329390 SPN23F_18650 Streptococcus pneumoniae ATCC 700669 DNA modification methylase YP_002511741.1 1811847 D 561276 CDS YP_002511742.1 221232588 7329391 complement(1813158..1813562) 1 NC_011900.1 thioesterase superfamily protein 1813562 7329391 SPN23F_18660 Streptococcus pneumoniae ATCC 700669 thioesterase superfamily protein YP_002511742.1 1813158 R 561276 CDS YP_002511743.1 221232589 7329392 complement(1813632..1815113) 1 NC_011900.1 catalyzes the formation of alpha-D-glucose 1-phosphate and UDP-galactose from UDP-glucose and alpha-D-galactose 1-phosphate in galactose metabolism; galactose-1-phosphate uridylyltransferase 1815113 galT 7329392 galT Streptococcus pneumoniae ATCC 700669 galactose-1-phosphate uridylyltransferase YP_002511743.1 1813632 R 561276 CDS YP_002511744.1 221232590 7328584 complement(1815132..1816310) 1 NC_011900.1 catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase 1816310 galK 7328584 galK Streptococcus pneumoniae ATCC 700669 galactokinase YP_002511744.1 1815132 R 561276 CDS YP_002511745.1 221232591 7328582 1816475..1817482 1 NC_011900.1 galactose operon repressor 1817482 galR 7328582 galR Streptococcus pneumoniae ATCC 700669 galactose operon repressor YP_002511745.1 1816475 D 561276 CDS YP_002511746.1 221232592 7328583 complement(1817528..1818565) 1 NC_011900.1 zinc-binding dehydrogenase 1818565 7328583 SPN23F_18700 Streptococcus pneumoniae ATCC 700669 zinc-binding dehydrogenase YP_002511746.1 1817528 R 561276 CDS YP_002511747.1 221232593 7329393 complement(1818566..1818919) 1 NC_011900.1 MerR family transcriptional regulator 1818919 7329393 SPN23F_18710 Streptococcus pneumoniae ATCC 700669 MerR family transcriptional regulator YP_002511747.1 1818566 R 561276 CDS YP_002511748.1 221232594 7329394 complement(1819163..1820053) 1 NC_011900.1 cation efflux family protein 1820053 7329394 SPN23F_18720 Streptococcus pneumoniae ATCC 700669 cation efflux family protein YP_002511748.1 1819163 R 561276 CDS YP_002511749.1 221232595 7329395 1820186..1820722 1 NC_011900.1 TetR family transcriptional regulator 1820722 7329395 SPN23F_18730 Streptococcus pneumoniae ATCC 700669 TetR family transcriptional regulator YP_002511749.1 1820186 D 561276 CDS YP_002511750.1 221232596 7329396 complement(1820889..1821695) 1 NC_011900.1 nicotinamide mononucleotide transporter 1821695 7329396 SPN23F_18740 Streptococcus pneumoniae ATCC 700669 nicotinamide mononucleotide transporter YP_002511750.1 1820889 R 561276 CDS YP_002511751.1 221232597 7329397 complement(1822040..1823560) 1 NC_011900.1 glycine/betaine ABC transporter 1823560 7329397 SPN23F_18750 Streptococcus pneumoniae ATCC 700669 glycine/betaine ABC transporter YP_002511751.1 1822040 R 561276 CDS YP_002511752.1 221232598 7329398 complement(1823553..1824281) 1 NC_011900.1 glycine/betaine ABC transporter ATP-binding protein 1824281 7329398 SPN23F_18760 Streptococcus pneumoniae ATCC 700669 glycine/betaine ABC transporter ATP-binding protein YP_002511752.1 1823553 R 561276 CDS YP_002511753.1 221232599 7329399 complement(1824296..1825060) 1 NC_011900.1 hypothetical protein 1825060 7329399 SPN23F_18770 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511753.1 1824296 R 561276 CDS YP_002511754.1 221232600 7329400 complement(1825064..1825507) 1 NC_011900.1 MarR-family transcriptional regulator 1825507 7329400 SPN23F_18780 Streptococcus pneumoniae ATCC 700669 MarR-family transcriptional regulator YP_002511754.1 1825064 R 561276 CDS YP_002511755.1 221232601 7329401 complement(1826189..1826485) 1 NC_011900.1 hypothetical protein 1826485 7329401 SPN23F_18790 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511755.1 1826189 R 561276 CDS YP_002511756.1 221232602 7329402 complement(1826507..1827571) 1 NC_011900.1 glutamyl-aminopeptidase 1827571 pepA 7329402 pepA Streptococcus pneumoniae ATCC 700669 glutamyl-aminopeptidase YP_002511756.1 1826507 R 561276 CDS YP_002511757.1 221232603 7327823 1827972..1828673 1 NC_011900.1 UDP-glucose 4-epimerase 1828673 7327823 SPN23F_18810 Streptococcus pneumoniae ATCC 700669 UDP-glucose 4-epimerase YP_002511757.1 1827972 D 561276 CDS YP_002511758.1 221232604 7329403 1829096..1830055 1 NC_011900.1 iron compound ABC transporter permease 1830055 7329403 SPN23F_18820 Streptococcus pneumoniae ATCC 700669 iron compound ABC transporter permease YP_002511758.1 1829096 D 561276 CDS YP_002511759.1 221232605 7329404 1830045..1831001 1 NC_011900.1 iron compound ABC transporter permease 1831001 7329404 SPN23F_18830 Streptococcus pneumoniae ATCC 700669 iron compound ABC transporter permease YP_002511759.1 1830045 D 561276 CDS YP_002511760.1 221232606 7329405 1830998..1831750 1 NC_011900.1 siderophore uptake ATP-binding protein 1831750 7329405 SPN23F_18840 Streptococcus pneumoniae ATCC 700669 siderophore uptake ATP-binding protein YP_002511760.1 1830998 D 561276 CDS YP_002511761.1 221232607 7329406 1831846..1832811 1 NC_011900.1 siderophore uptake periplasmic binding protein 1832811 7329406 SPN23F_18850 Streptococcus pneumoniae ATCC 700669 siderophore uptake periplasmic binding protein YP_002511761.1 1831846 D 561276 CDS YP_002511762.1 221232608 7329407 complement(1833036..1833278) 1 NC_011900.1 hypothetical protein 1833278 7329407 SPN23F_18860 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511762.1 1833036 R 561276 CDS YP_002511763.1 221232609 7329408 complement(1833278..1834000) 1 NC_011900.1 ribosomal large subunit pseudouridine synthase B 1834000 rluB 7329408 rluB Streptococcus pneumoniae ATCC 700669 ribosomal large subunit pseudouridine synthase B YP_002511763.1 1833278 R 561276 CDS YP_002511764.1 221232610 7327458 complement(1833987..1834556) 1 NC_011900.1 functions during chromosome segregation; may form a condensin-like structure with SMC and ScpA; forms a homodimer; segregation and condensation protein B 1834556 scpB 7327458 scpB Streptococcus pneumoniae ATCC 700669 segregation and condensation protein B YP_002511764.1 1833987 R 561276 CDS YP_002511765.1 221232611 7329133 complement(1834575..1835303) 1 NC_011900.1 functions during chromosome segregation; may form a condensin-like structure with SMC and ScpB; segregation and condensation protein A 1835303 scpA 7329133 scpA Streptococcus pneumoniae ATCC 700669 segregation and condensation protein A YP_002511765.1 1834575 R 561276 CDS YP_002511766.1 221232612 7329132 complement(1835303..1836037) 1 NC_011900.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD-like protein 1836037 xerD 7329132 xerD Streptococcus pneumoniae ATCC 700669 site-specific tyrosine recombinase XerD-like protein YP_002511766.1 1835303 R 561276 CDS YP_002511767.1 221232613 7329446 complement(1836034..1836495) 1 NC_011900.1 hypothetical protein 1836495 7329446 SPN23F_18910 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511767.1 1836034 R 561276 CDS YP_002511768.1 221232614 7329409 complement(1836492..1837013) 1 NC_011900.1 phosphoesterase 1837013 7329409 SPN23F_18920 Streptococcus pneumoniae ATCC 700669 phosphoesterase YP_002511768.1 1836492 R 561276 CDS YP_002511769.1 221232615 7329410 complement(1836989..1837960) 1 NC_011900.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; deoxyribonucleotide triphosphate pyrophosphatase/hypothetical protein 1837960 7329410 SPN23F_18930 Streptococcus pneumoniae ATCC 700669 deoxyribonucleotide triphosphate pyrophosphatase/hypothetical protein YP_002511769.1 1836989 R 561276 CDS YP_002511770.1 221232616 7329411 complement(1837957..1838751) 1 NC_011900.1 converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 1838751 glr 7329411 glr Streptococcus pneumoniae ATCC 700669 glutamate racemase YP_002511770.1 1837957 R 561276 CDS YP_002511771.1 221232617 7328611 complement(1838958..1839206) 1 NC_011900.1 hypothetical protein 1839206 7328611 SPN23F_18950 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511771.1 1838958 R 561276 CDS YP_002511772.1 221232618 7329412 complement(1839462..1841087) 1 NC_011900.1 trehalose-6-phosphate hydrolase 1841087 treA 7329412 treA Streptococcus pneumoniae ATCC 700669 trehalose-6-phosphate hydrolase YP_002511772.1 1839462 R 561276 CDS YP_002511773.1 221232619 7327583 complement(1841265..1843232) 1 NC_011900.1 sugar phosphotransferase system (PTS), IIABC component 1843232 7327583 SPN23F_18970 Streptococcus pneumoniae ATCC 700669 sugar phosphotransferase system (PTS), IIABC component YP_002511773.1 1841265 R 561276 CDS YP_002511774.1 221232620 7329413 1843417..1844127 1 NC_011900.1 GntR family transcriptional regulator 1844127 7329413 SPN23F_18980 Streptococcus pneumoniae ATCC 700669 GntR family transcriptional regulator YP_002511774.1 1843417 D 561276 CDS YP_002511775.1 221232621 7329414 complement(1844160..1844963) 1 NC_011900.1 ABC transporter ATP-binding protein 1844963 7329414 SPN23F_18990 Streptococcus pneumoniae ATCC 700669 ABC transporter ATP-binding protein YP_002511775.1 1844160 R 561276 CDS YP_002511776.1 221232622 7329415 complement(1844976..1845869) 1 NC_011900.1 transport system permease protein 1845869 7329415 SPN23F_19000 Streptococcus pneumoniae ATCC 700669 transport system permease protein YP_002511776.1 1844976 R 561276 CDS YP_002511777.1 221232623 7329418 complement(1847309..1848235) 1 NC_011900.1 peptide ABC transporter ATP-binding protein 1848235 7329418 SPN23F_19050 Streptococcus pneumoniae ATCC 700669 peptide ABC transporter ATP-binding protein YP_002511777.1 1847309 R 561276 CDS YP_002511778.1 221232624 7329419 complement(1848246..1849313) 1 NC_011900.1 peptide ABC transporter ATP-binding protein 1849313 7329419 SPN23F_19060 Streptococcus pneumoniae ATCC 700669 peptide ABC transporter ATP-binding protein YP_002511778.1 1848246 R 561276 CDS YP_002511779.1 221232625 7328302 complement(1849322..1850248) 1 NC_011900.1 peptide ABC transporter permease 1850248 7328302 SPN23F_19070 Streptococcus pneumoniae ATCC 700669 peptide ABC transporter permease YP_002511779.1 1849322 R 561276 CDS YP_002511780.1 221232626 7328304 complement(1850248..1851501) 1 NC_011900.1 peptide ABC transporter permease 1851501 7328304 SPN23F_19080 Streptococcus pneumoniae ATCC 700669 peptide ABC transporter permease YP_002511780.1 1850248 R 561276 CDS YP_002511781.1 221232627 7328305 complement(1851517..1851744) 1 NC_011900.1 peptide ABC transporter permease 1851744 7328305 SPN23F_19090 Streptococcus pneumoniae ATCC 700669 peptide ABC transporter permease YP_002511781.1 1851517 R 561276 CDS YP_002511782.1 221232628 7328306 complement(1851811..1853790) 1 NC_011900.1 extracellular oligopeptide-binding protein 1853790 7328306 SPN23F_19100 Streptococcus pneumoniae ATCC 700669 extracellular oligopeptide-binding protein YP_002511782.1 1851811 R 561276 CDS YP_002511783.1 221232629 7328307 complement(1854476..1855669) 1 NC_011900.1 polysaccharide repeat unit polymerase 1855669 7328307 SPN23F_19110 Streptococcus pneumoniae ATCC 700669 polysaccharide repeat unit polymerase YP_002511783.1 1854476 R 561276 CDS YP_002511784.1 221232630 7328308 complement(1855807..1857249) 1 NC_011900.1 sucrose phosphorylase 1857249 7328308 SPN23F_19120 Streptococcus pneumoniae ATCC 700669 sucrose phosphorylase YP_002511784.1 1855807 R 561276 CDS YP_002511785.1 221232631 7328309 complement(1857607..1858440) 1 NC_011900.1 multiple sugar-binding transport system permease protein 1858440 msmG 7328309 msmG Streptococcus pneumoniae ATCC 700669 multiple sugar-binding transport system permease protein YP_002511785.1 1857607 R 561276 CDS YP_002511786.1 221232632 7328137 complement(1858454..1859320) 1 NC_011900.1 multiple sugar-binding transport system permease protein 1859320 msmF 7328137 msmF Streptococcus pneumoniae ATCC 700669 multiple sugar-binding transport system permease protein YP_002511786.1 1858454 R 561276 CDS YP_002511787.1 221232633 7328136 complement(1859334..1860593) 1 NC_011900.1 multiple sugar-binding protein precursor 1860593 msmE 7328136 msmE Streptococcus pneumoniae ATCC 700669 multiple sugar-binding protein precursor YP_002511787.1 1859334 R 561276 CDS YP_002511788.1 221232634 7328135 complement(1860685..1862847) 1 NC_011900.1 alpha-galactosidase 1862847 aga 7328135 aga Streptococcus pneumoniae ATCC 700669 alpha-galactosidase YP_002511788.1 1860685 R 561276 CDS YP_002511789.1 221232635 7328639 1862955..1863815 1 NC_011900.1 AraC family transcriptional regulator 1863815 msmR 7328639 msmR Streptococcus pneumoniae ATCC 700669 AraC family transcriptional regulator YP_002511789.1 1862955 D 561276 CDS YP_002511790.1 221232636 7328139 1863812..1864747 1 NC_011900.1 catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; biotin--protein ligase 1864747 birA 7328139 birA Streptococcus pneumoniae ATCC 700669 biotin--protein ligase YP_002511790.1 1863812 D 561276 CDS YP_002511791.1 221232637 7327604 complement(1873080..1874423) 1 NC_011900.1 RNA methyltransferase 1874423 7327604 SPN23F_19230 Streptococcus pneumoniae ATCC 700669 RNA methyltransferase YP_002511791.1 1873080 R 561276 CDS YP_002511792.1 221232638 7328311 1874473..1875249 1 NC_011900.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 1875249 recX 7328311 recX Streptococcus pneumoniae ATCC 700669 recombination regulator RecX YP_002511792.1 1874473 D 561276 CDS YP_002511793.1 221232639 7328312 1875338..1875871 1 NC_011900.1 hypothetical protein 1875871 7328312 SPN23F_19250 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511793.1 1875338 D 561276 CDS YP_002511794.1 221232640 7328315 complement(1878020..1879642) 1 NC_011900.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; chaperonin GroEL 1879642 groEL 7328315 groEL Streptococcus pneumoniae ATCC 700669 chaperonin GroEL YP_002511794.1 1878020 R 561276 CDS YP_002511795.1 221232641 7328622 complement(1879658..1879942) 1 NC_011900.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 1879942 groES 7328622 groES Streptococcus pneumoniae ATCC 700669 co-chaperonin GroES YP_002511795.1 1879658 R 561276 CDS YP_002511796.1 221232642 7328061 complement(1880098..1880493) 1 NC_011900.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein 1880493 7328061 SPN23F_19320 Streptococcus pneumoniae ATCC 700669 single-stranded DNA-binding protein YP_002511796.1 1880098 R 561276 CDS YP_002511797.1 221232643 7328316 complement(1880571..1881332) 1 NC_011900.1 NADP-dependent L-serine/L-allo-threonine dehydrogenase 1881332 7328316 SPN23F_19330 Streptococcus pneumoniae ATCC 700669 NADP-dependent L-serine/L-allo-threonine dehydrogenase YP_002511797.1 1880571 R 561276 CDS YP_002511798.1 221232644 7328317 complement(1881374..1882000) 1 NC_011900.1 tRNA-binding protein 1882000 7328317 SPN23F_19340 Streptococcus pneumoniae ATCC 700669 tRNA-binding protein YP_002511798.1 1881374 R 561276 CDS YP_002511799.1 221232645 7328318 complement(1882016..1882333) 1 NC_011900.1 thioredoxin 1882333 7328318 SPN23F_19350 Streptococcus pneumoniae ATCC 700669 thioredoxin YP_002511799.1 1882016 R 561276 CDS YP_002511800.1 221232646 7328319 complement(1882330..1882620) 1 NC_011900.1 hypothetical protein 1882620 7328319 SPN23F_19360 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511800.1 1882330 R 561276 CDS YP_002511801.1 221232647 7328320 complement(1882914..1883015) 1 NC_011900.1 may be a gene fragment; cell wall-binding protein 1883015 7328320 SPN23F_19370 Streptococcus pneumoniae ATCC 700669 cell wall-binding protein YP_002511801.1 1882914 R 561276 CDS YP_002511802.1 221232648 7328321 complement(1883266..1883940) 1 NC_011900.1 hypothetical protein 1883940 7328321 SPN23F_19380 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511802.1 1883266 R 561276 CDS YP_002511803.1 221232649 7328322 complement(1883946..1884392) 1 NC_011900.1 DNA-binding protein 1884392 7328322 SPN23F_19390 Streptococcus pneumoniae ATCC 700669 DNA-binding protein YP_002511803.1 1883946 R 561276 CDS YP_002511804.1 221232650 7328323 complement(1884506..1885009) 1 NC_011900.1 PAP2 superfamily membrane protein 1885009 7328323 SPN23F_19400 Streptococcus pneumoniae ATCC 700669 PAP2 superfamily membrane protein YP_002511804.1 1884506 R 561276 CDS YP_002511805.1 221232651 7328324 complement(1885006..1885368) 1 NC_011900.1 hypothetical protein 1885368 7328324 SPN23F_19410 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511805.1 1885006 R 561276 CDS YP_002511806.1 221232652 7328327 complement(1886472..1887293) 1 NC_011900.1 ABC transporter ATP-binding protein/permease 1887293 7328327 SPN23F_19440 Streptococcus pneumoniae ATCC 700669 ABC transporter ATP-binding protein/permease YP_002511806.1 1886472 R 561276 CDS YP_002511807.1 221232653 7328328 complement(1887331..1887780) 1 NC_011900.1 MarR family transcriptional regulator 1887780 7328328 SPN23F_19450 Streptococcus pneumoniae ATCC 700669 MarR family transcriptional regulator YP_002511807.1 1887331 R 561276 CDS YP_002511808.1 221232654 7328329 complement(1887904..1888620) 1 NC_011900.1 hypothetical protein 1888620 7328329 SPN23F_19460 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511808.1 1887904 R 561276 CDS YP_002511809.1 221232655 7328330 complement(1889503..1890918) 1 NC_011900.1 pneumolysin (thiol-activated cytolysin) 1890918 ply 7328330 ply Streptococcus pneumoniae ATCC 700669 pneumolysin (thiol-activated cytolysin) YP_002511809.1 1889503 R 561276 CDS YP_002511810.1 221232656 7327853 complement(1890929..1891261) 1 NC_011900.1 hypothetical protein 1891261 7327853 SPN23F_19480 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511810.1 1890929 R 561276 CDS YP_002511811.1 221232657 7328331 complement(1891332..1891940) 1 NC_011900.1 hypothetical protein 1891940 7328331 SPN23F_19490 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511811.1 1891332 R 561276 CDS YP_002511812.1 221232658 7328332 complement(1891953..1892411) 1 NC_011900.1 hypothetical protein 1892411 7328332 SPN23F_19500 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511812.1 1891953 R 561276 CDS YP_002511813.1 221232659 7328335 complement(1894103..1894363) 1 NC_011900.1 hypothetical protein 1894363 7328335 SPN23F_19530 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511813.1 1894103 R 561276 CDS YP_002511814.1 221232660 7328336 complement(1894422..1894973) 1 NC_011900.1 hypothetical protein 1894973 7328336 SPN23F_19540 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511814.1 1894422 R 561276 CDS YP_002511815.1 221232661 7328337 complement(1894963..1895160) 1 NC_011900.1 hypothetical protein 1895160 7328337 SPN23F_19550 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511815.1 1894963 R 561276 CDS YP_002511816.1 221232662 7328338 complement(1895164..1895958) 1 NC_011900.1 hypothetical protein 1895958 7328338 SPN23F_19560 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511816.1 1895164 R 561276 CDS YP_002511817.1 221232663 7328339 complement(1896366..1896791) 1 NC_011900.1 hypothetical protein 1896791 7328339 SPN23F_19570 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511817.1 1896366 R 561276 CDS YP_002511818.1 221232664 7328340 complement(1896920..1897279) 1 NC_011900.1 hypothetical protein 1897279 7328340 SPN23F_19580 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511818.1 1896920 R 561276 CDS YP_002511819.1 221232665 7328341 complement(1897518..1897679) 1 NC_011900.1 DNA-binding protein 1897679 7328341 SPN23F_19590 Streptococcus pneumoniae ATCC 700669 DNA-binding protein YP_002511819.1 1897518 R 561276 CDS YP_002511820.1 221232666 7328342 complement(1898038..1898994) 1 NC_011900.1 No appparent secretion signal; cell wall-binding amidase 1898994 7328342 SPN23F_19600 Streptococcus pneumoniae ATCC 700669 cell wall-binding amidase YP_002511820.1 1898038 R 561276 CDS YP_002511821.1 221232667 7328343 complement(1899370..1900740) 1 NC_011900.1 drug/sodium antiporter 1900740 7328343 SPN23F_19610 Streptococcus pneumoniae ATCC 700669 drug/sodium antiporter YP_002511821.1 1899370 R 561276 CDS YP_002511822.1 221232668 7328344 complement(1901047..1902213) 1 NC_011900.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A 1902213 recA 7328344 recA Streptococcus pneumoniae ATCC 700669 recombinase A YP_002511822.1 1901047 R 561276 CDS YP_002511823.1 221232669 7327442 complement(1902268..1903524) 1 NC_011900.1 competence damage-inducible protein A 1903524 cinA 7327442 cinA Streptococcus pneumoniae ATCC 700669 competence damage-inducible protein A YP_002511823.1 1902268 R 561276 CDS YP_002511824.1 221232670 7329194 complement(1903609..1904625) 1 NC_011900.1 LytR family transcriptional regulator 1904625 7329194 SPN23F_19640 Streptococcus pneumoniae ATCC 700669 LytR family transcriptional regulator YP_002511824.1 1903609 R 561276 CDS YP_002511825.1 221232671 7328345 complement(1904633..1905151) 1 NC_011900.1 GNAT family acetyltransferase 1905151 7328345 SPN23F_19650 Streptococcus pneumoniae ATCC 700669 GNAT family acetyltransferase YP_002511825.1 1904633 R 561276 CDS YP_002511826.1 221232672 7328346 complement(1905141..1905584) 1 NC_011900.1 P-loop hydrolase 1905584 7328346 SPN23F_19660 Streptococcus pneumoniae ATCC 700669 P-loop hydrolase YP_002511826.1 1905141 R 561276 CDS YP_002511827.1 221232673 7328347 complement(1905670..1906290) 1 NC_011900.1 hypothetical protein 1906290 7328347 SPN23F_19670 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511827.1 1905670 R 561276 CDS YP_002511828.1 221232674 7328348 complement(1906673..1907536) 1 NC_011900.1 transcriptional regulator 1907536 7328348 SPN23F_19680 Streptococcus pneumoniae ATCC 700669 transcriptional regulator YP_002511828.1 1906673 R 561276 CDS YP_002511829.1 221232675 7328349 1907728..1907898 1 NC_011900.1 secreted protein 1907898 7328349 SPN23F_19690 Streptococcus pneumoniae ATCC 700669 secreted protein YP_002511829.1 1907728 D 561276 CDS YP_002511830.1 221232676 7328350 1908001..1908225 1 NC_011900.1 hypothetical protein 1908225 7328350 SPN23F_19700 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511830.1 1908001 D 561276 CDS YP_002511831.1 221232677 7328351 1908232..1908420 1 NC_011900.1 hypothetical protein 1908420 7328351 SPN23F_19710 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511831.1 1908232 D 561276 CDS YP_002511832.1 221232678 7328352 1908536..1911526 1 NC_011900.1 lantibiotic modifying enzyme 1911526 7328352 SPN23F_19720 Streptococcus pneumoniae ATCC 700669 lantibiotic modifying enzyme YP_002511832.1 1908536 D 561276 CDS YP_002511833.1 221232679 7328353 1911876..1912580 1 NC_011900.1 hypothetical protein 1912580 7328353 SPN23F_19730 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511833.1 1911876 D 561276 CDS YP_002511834.1 221232680 7328354 1912561..1913490 1 NC_011900.1 hypothetical protein 1913490 7328354 SPN23F_19740 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511834.1 1912561 D 561276 CDS YP_002511835.1 221232681 7328355 1913487..1915595 1 NC_011900.1 bacteriocin secretion/processing ATP-binding protein 1915595 7328355 SPN23F_19750 Streptococcus pneumoniae ATCC 700669 bacteriocin secretion/processing ATP-binding protein YP_002511835.1 1913487 D 561276 CDS YP_002511836.1 221232682 7328356 1915619..1917358 1 NC_011900.1 lantibiotic leader peptide processing serine protease 1917358 7328356 SPN23F_19760 Streptococcus pneumoniae ATCC 700669 lantibiotic leader peptide processing serine protease YP_002511836.1 1915619 D 561276 CDS YP_002511837.1 221232683 7328358 1918178..1918810 1 NC_011900.1 ABC transporter ATP-binding protein 1918810 7328358 SPN23F_19780 Streptococcus pneumoniae ATCC 700669 ABC transporter ATP-binding protein YP_002511837.1 1918178 D 561276 CDS YP_002511838.1 221232684 7328359 1918968..1919129 1 NC_011900.1 hypothetical protein 1919129 7328359 SPN23F_19790 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511838.1 1918968 D 561276 CDS YP_002511839.1 221232685 7328360 complement(1919755..1920168) 1 NC_011900.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase 1920168 ndk 7328360 ndk Streptococcus pneumoniae ATCC 700669 nucleoside diphosphate kinase YP_002511839.1 1919755 R 561276 CDS YP_002511840.1 221232686 7328419 complement(1920279..1923956) 1 NC_011900.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 1923956 rpoC 7328419 rpoC Streptococcus pneumoniae ATCC 700669 DNA-directed RNA polymerase subunit beta' YP_002511840.1 1920279 R 561276 CDS YP_002511841.1 221232687 7329105 complement(1923989..1927600) 1 NC_011900.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 1927600 rpoB 7329105 rpoB Streptococcus pneumoniae ATCC 700669 DNA-directed RNA polymerase subunit beta YP_002511841.1 1923989 R 561276 CDS YP_002511842.1 221232688 7327600 complement(1928284..1929615) 1 NC_011900.1 transport protein 1929615 7327600 SPN23F_19830 Streptococcus pneumoniae ATCC 700669 transport protein YP_002511842.1 1928284 R 561276 CDS YP_002511843.1 221232689 7328361 complement(1929844..1930668) 1 NC_011900.1 competence associated endonuclease 1930668 endA 7328361 endA Streptococcus pneumoniae ATCC 700669 competence associated endonuclease YP_002511843.1 1929844 R 561276 CDS YP_002511844.1 221232690 7329252 complement(1930707..1930895) 1 NC_011900.1 competence associated protein 1930895 epuA 7329252 epuA Streptococcus pneumoniae ATCC 700669 competence associated protein YP_002511844.1 1930707 R 561276 CDS YP_002511845.1 221232691 7329257 complement(1930888..1932171) 1 NC_011900.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1932171 murA1 7329257 murA1 Streptococcus pneumoniae ATCC 700669 UDP-N-acetylglucosamine 1-carboxyvinyltransferase YP_002511845.1 1930888 R 561276 CDS YP_002511846.1 221232692 7328391 complement(1932195..1932425) 1 NC_011900.1 hypothetical protein 1932425 7328391 SPN23F_19870 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511846.1 1932195 R 561276 CDS YP_002511847.1 221232693 7328362 complement(1932483..1933520) 1 NC_011900.1 hypothetical protein 1933520 7328362 SPN23F_19880 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511847.1 1932483 R 561276 CDS YP_002511848.1 221232694 7328363 complement(1933504..1933992) 1 NC_011900.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 1933992 coaD 7328363 coaD Streptococcus pneumoniae ATCC 700669 phosphopantetheine adenylyltransferase YP_002511848.1 1933504 R 561276 CDS YP_002511849.1 221232695 7329203 complement(1933982..1934521) 1 NC_011900.1 methylase 1934521 7329203 SPN23F_19900 Streptococcus pneumoniae ATCC 700669 methylase YP_002511849.1 1933982 R 561276 CDS YP_002511850.1 221232696 7328364 complement(1934586..1935578) 1 NC_011900.1 catalyzes the formation of asparagine from aspartate and ammonia; asparagine synthetase AsnA 1935578 asnA 7328364 asnA Streptococcus pneumoniae ATCC 700669 asparagine synthetase AsnA YP_002511850.1 1934586 R 561276 CDS YP_002511851.1 221232697 7328667 complement(1935690..1936373) 1 NC_011900.1 hypothetical protein 1936373 7328667 SPN23F_19930 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511851.1 1935690 R 561276 CDS YP_002511852.1 221232698 7328365 complement(1936429..1937169) 1 NC_011900.1 SpoU rRNA Methylase family protein 1937169 7328365 SPN23F_19940 Streptococcus pneumoniae ATCC 700669 SpoU rRNA Methylase family protein YP_002511852.1 1936429 R 561276 CDS YP_002511853.1 221232699 7328366 1937203..1937481 1 NC_011900.1 catalyzes the hydrolysis of acylphosphate; acylphosphatase 1937481 7328366 SPN23F_19950 Streptococcus pneumoniae ATCC 700669 acylphosphatase YP_002511853.1 1937203 D 561276 CDS YP_002511854.1 221232700 7328367 1937559..1938485 1 NC_011900.1 involved in biogenesis of membrane proteins; Firmicutes specific proteins are shorter than other bacterial counterparts and have a signal peptide and lipid attachment site; OxaA-like protein precursor 1938485 7328367 SPN23F_19960 Streptococcus pneumoniae ATCC 700669 OxaA-like protein precursor YP_002511854.1 1937559 D 561276 CDS YP_002511855.1 221232701 7328368 complement(1938560..1939354) 1 NC_011900.1 pyruvate formate-lyase activating enzyme 1939354 pflC 7328368 pflC Streptococcus pneumoniae ATCC 700669 pyruvate formate-lyase activating enzyme YP_002511855.1 1938560 R 561276 CDS YP_002511856.1 221232702 7327835 complement(1939480..1940730) 1 NC_011900.1 pyridoxal-dependent decarboxylase 1940730 7327835 SPN23F_19980 Streptococcus pneumoniae ATCC 700669 pyridoxal-dependent decarboxylase YP_002511856.1 1939480 R 561276 CDS YP_002511857.1 221232703 7328369 complement(1940797..1941624) 1 NC_011900.1 pur operon repressor 1941624 purR 7328369 purR Streptococcus pneumoniae ATCC 700669 pur operon repressor YP_002511857.1 1940797 R 561276 CDS YP_002511858.1 221232704 7327426 complement(1941891..1942832) 1 NC_011900.1 3'-5' exoribonuclease 1942832 7327426 SPN23F_20000 Streptococcus pneumoniae ATCC 700669 3'-5' exoribonuclease YP_002511858.1 1941891 R 561276 CDS YP_002511859.1 221232705 7328370 complement(1942822..1944078) 1 NC_011900.1 RmuC family protein 1944078 7328370 SPN23F_20010 Streptococcus pneumoniae ATCC 700669 RmuC family protein YP_002511859.1 1942822 R 561276 CDS YP_002511860.1 221232706 7328371 complement(1944080..1944742) 1 NC_011900.1 thiamin pyrophosphokinase 1944742 thiN 7328371 thiN Streptococcus pneumoniae ATCC 700669 thiamin pyrophosphokinase YP_002511860.1 1944080 R 561276 CDS YP_002511861.1 221232707 7329172 complement(1944705..1945361) 1 NC_011900.1 ribulose-phosphate 3-epimerase 1945361 rpe 7329172 rpe Streptococcus pneumoniae ATCC 700669 ribulose-phosphate 3-epimerase YP_002511861.1 1944705 R 561276 CDS YP_002511862.1 221232708 7327468 complement(1945372..1946250) 1 NC_011900.1 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity; ribosome-associated GTPase 1946250 engC 7327468 engC Streptococcus pneumoniae ATCC 700669 ribosome-associated GTPase YP_002511862.1 1945372 R 561276 CDS YP_002511863.1 221232709 7329255 complement(1946252..1947124) 1 NC_011900.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 1947124 ksgA 7329255 ksgA Streptococcus pneumoniae ATCC 700669 dimethyladenosine transferase YP_002511863.1 1946252 R 561276 CDS YP_002511864.1 221232710 7328090 complement(1947255..1947563) 1 NC_011900.1 hypothetical protein 1947563 7328090 SPN23F_20060 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511864.1 1947255 R 561276 CDS YP_002511865.1 221232711 7328372 complement(1947556..1948197) 1 NC_011900.1 ABC transporter ATP-binding protein 1948197 7328372 SPN23F_20070 Streptococcus pneumoniae ATCC 700669 ABC transporter ATP-binding protein YP_002511865.1 1947556 R 561276 CDS YP_002511866.1 221232712 7328373 complement(1948199..1950229) 1 NC_011900.1 hypothetical protein 1950229 7328373 SPN23F_20080 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511866.1 1948199 R 561276 CDS YP_002511867.1 221232713 7328374 complement(1950306..1950602) 1 NC_011900.1 hypothetical protein 1950602 7328374 SPN23F_20090 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511867.1 1950306 R 561276 CDS YP_002511868.1 221232714 7328375 complement(1950922..1951821) 1 NC_011900.1 DNA-binding protein 1951821 7328375 SPN23F_20100 Streptococcus pneumoniae ATCC 700669 DNA-binding protein YP_002511868.1 1950922 R 561276 CDS YP_002511869.1 221232715 7328376 complement(1951893..1952453) 1 NC_011900.1 hypothetical protein 1952453 7328376 SPN23F_20110 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511869.1 1951893 R 561276 CDS YP_002511870.1 221232716 7328377 complement(1952453..1953226) 1 NC_011900.1 TatD related DNase 1953226 7328377 SPN23F_20120 Streptococcus pneumoniae ATCC 700669 TatD related DNase YP_002511870.1 1952453 R 561276 CDS YP_002511871.1 221232717 7328379 complement(1954708..1954842) 1 NC_011900.1 in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 1954842 rpmH 7328379 rpmH Streptococcus pneumoniae ATCC 700669 50S ribosomal protein L34 YP_002511871.1 1954708 R 561276 CDS YP_002511872.1 221232718 7329101 complement(1954987..1956201) 1 NC_011900.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase AlaT 1956201 7329101 SPN23F_20150 Streptococcus pneumoniae ATCC 700669 aminotransferase AlaT YP_002511872.1 1954987 R 561276 CDS YP_002511873.1 221232719 7328380 complement(1956357..1956650) 1 NC_011900.1 hypothetical protein 1956650 7328380 SPN23F_20160 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511873.1 1956357 R 561276 CDS YP_002511874.1 221232720 7328381 1956812..1957264 1 NC_011900.1 universal stress protein 1957264 7328381 SPN23F_20170 Streptococcus pneumoniae ATCC 700669 universal stress protein YP_002511874.1 1956812 D 561276 CDS YP_002511875.1 221232721 7328382 complement(1957299..1958687) 1 NC_011900.1 haloacid dehalogenase-like hydrolase 1958687 7328382 SPN23F_20180 Streptococcus pneumoniae ATCC 700669 haloacid dehalogenase-like hydrolase YP_002511875.1 1957299 R 561276 CDS YP_002511876.1 221232722 7327900 1958753..1959715 1 NC_011900.1 L-asparaginase 1959715 asnB 7327900 asnB Streptococcus pneumoniae ATCC 700669 L-asparaginase YP_002511876.1 1958753 D 561276 CDS YP_002511877.1 221232723 7328668 complement(1959921..1960931) 1 NC_011900.1 catabolite control protein A 1960931 ccpA 7328668 ccpA Streptococcus pneumoniae ATCC 700669 catabolite control protein A YP_002511877.1 1959921 R 561276 CDS YP_002511878.1 221232724 7329189 complement(1961356..1961955) 1 NC_011900.1 response regulator protein 1961955 7329189 SPN23F_20210 Streptococcus pneumoniae ATCC 700669 response regulator protein YP_002511878.1 1961356 R 561276 CDS YP_002511879.1 221232725 7327980 complement(1961957..1963054) 1 NC_011900.1 histidine sensor kinase protein 1963054 7327980 SPN23F_20220 Streptococcus pneumoniae ATCC 700669 histidine sensor kinase protein YP_002511879.1 1961957 R 561276 CDS YP_002511880.1 221232726 7327981 complement(1963054..1963791) 1 NC_011900.1 ABC transporter 1963791 7327981 SPN23F_20230 Streptococcus pneumoniae ATCC 700669 ABC transporter YP_002511880.1 1963054 R 561276 CDS YP_002511881.1 221232727 7327982 complement(1963793..1964677) 1 NC_011900.1 ABC transporter ATP-binding protein 1964677 7327982 SPN23F_20240 Streptococcus pneumoniae ATCC 700669 ABC transporter ATP-binding protein YP_002511881.1 1963793 R 561276 CDS YP_002511882.1 221232728 7327983 complement(1964664..1964858) 1 NC_011900.1 hypothetical protein 1964858 7327983 SPN23F_20250 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511882.1 1964664 R 561276 CDS YP_002511883.1 221232729 7327605 complement(1971741..1972220) 1 NC_011900.1 competence-specific global transcription modulator 1972220 comX 7327605 comX Streptococcus pneumoniae ATCC 700669 competence-specific global transcription modulator YP_002511883.1 1971741 R 561276 CDS YP_002511884.1 221232730 7329212 complement(1972342..1972878) 1 NC_011900.1 Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 1972878 nusG 7329212 nusG Streptococcus pneumoniae ATCC 700669 transcription antitermination protein NusG YP_002511884.1 1972342 R 561276 CDS YP_002511885.1 221232731 7328435 complement(1972933..1973109) 1 NC_011900.1 forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 1973109 secE 7328435 secE Streptococcus pneumoniae ATCC 700669 preprotein translocase subunit SecE YP_002511885.1 1972933 R 561276 CDS YP_002511886.1 221232732 7327986 complement(1973324..1975519) 1 NC_011900.1 penicillin-binding protein 2a 1975519 pbp2A 7327986 pbp2A Streptococcus pneumoniae ATCC 700669 penicillin-binding protein 2a YP_002511886.1 1973324 R 561276 CDS YP_002511887.1 221232733 7328455 1975645..1976481 1 NC_011900.1 RNA pseudouridylate synthase 1976481 7328455 SPN23F_20320 Streptococcus pneumoniae ATCC 700669 RNA pseudouridylate synthase YP_002511887.1 1975645 D 561276 CDS YP_002511888.1 221232734 7327987 complement(1976549..1977556) 1 NC_011900.1 glyceraldehyde-3-phosphate dehydrogenase, plasmin receptor 1977556 plr 7327987 plr Streptococcus pneumoniae ATCC 700669 glyceraldehyde-3-phosphate dehydrogenase, plasmin receptor YP_002511888.1 1976549 R 561276 CDS YP_002511889.1 221232735 7327851 complement(1977733..1978566) 1 NC_011900.1 puttaive FtsX-family transport protein 1978566 7327851 SPN23F_20340 Streptococcus pneumoniae ATCC 700669 puttaive FtsX-family transport protein YP_002511889.1 1977733 R 561276 CDS YP_002511890.1 221232736 7327990 complement(1979746..1980618) 1 NC_011900.1 catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; nicotinate-nucleotide pyrophosphorylase 1980618 nadC 7327990 nadC Streptococcus pneumoniae ATCC 700669 nicotinate-nucleotide pyrophosphorylase YP_002511890.1 1979746 R 561276 CDS YP_002511891.1 221232737 7328411 1980855..1982165 1 NC_011900.1 dicarboxylate carrier protein 1982165 7328411 SPN23F_20380 Streptococcus pneumoniae ATCC 700669 dicarboxylate carrier protein YP_002511891.1 1980855 D 561276 CDS YP_002511892.1 221232738 7327992 complement(1982531..1982662) 1 NC_011900.1 nucleotide-binding protein 1982662 7327992 SPN23F_20400 Streptococcus pneumoniae ATCC 700669 nucleotide-binding protein YP_002511892.1 1982531 R 561276 CDS YP_002511893.1 221232739 7327993 complement(1983185..1983913) 1 NC_011900.1 GntR family transcriptional regulator 1983913 treR 7327993 treR Streptococcus pneumoniae ATCC 700669 GntR family transcriptional regulator YP_002511893.1 1983185 R 561276 CDS YP_002511894.1 221232740 7327584 1984071..1985480 1 NC_011900.1 beta-glucosidase 1985480 7327584 SPN23F_20420 Streptococcus pneumoniae ATCC 700669 beta-glucosidase YP_002511894.1 1984071 D 561276 CDS YP_002511895.1 221232741 7327994 1985498..1986793 1 NC_011900.1 PTS system, lichenan-specific IIc component 1986793 licC 7327994 licC Streptococcus pneumoniae ATCC 700669 PTS system, lichenan-specific IIc component YP_002511895.1 1985498 D 561276 CDS YP_002511896.1 221232742 7328108 1986798..1987106 1 NC_011900.1 exported PTS system protein 1987106 7328108 SPN23F_20440 Streptococcus pneumoniae ATCC 700669 exported PTS system protein YP_002511896.1 1986798 D 561276 CDS YP_002511897.1 221232743 7327995 1987103..1987411 1 NC_011900.1 lactose-specific phosphotransferase system (PTS), IIA component 2 1987411 7327995 SPN23F_20450 Streptococcus pneumoniae ATCC 700669 lactose-specific phosphotransferase system (PTS), IIA component 2 YP_002511897.1 1987103 D 561276 CDS YP_002511898.1 221232744 7327996 complement(1988278..1990929) 1 NC_011900.1 bifunctional acetaldehyde-CoA/alcohol dehydrogenase 1990929 adhE 7327996 adhE Streptococcus pneumoniae ATCC 700669 bifunctional acetaldehyde-CoA/alcohol dehydrogenase YP_002511898.1 1988278 R 561276 CDS YP_002511899.1 221232745 7328636 complement(1991229..1991639) 1 NC_011900.1 hypothetical protein 1991639 7328636 SPN23F_20480 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511899.1 1991229 R 561276 CDS YP_002511900.1 221232746 7327997 complement(1991641..1992069) 1 NC_011900.1 phosphotyrosine protein phosphatase 1992069 7327997 SPN23F_20490 Streptococcus pneumoniae ATCC 700669 phosphotyrosine protein phosphatase YP_002511900.1 1991641 R 561276 CDS YP_002511901.1 221232747 7327998 complement(1992116..1992415) 1 NC_011900.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC 1992415 yajC 7327998 yajC Streptococcus pneumoniae ATCC 700669 preprotein translocase subunit YajC YP_002511901.1 1992116 R 561276 CDS YP_002511902.1 221232748 7327999 complement(1992532..1994508) 1 NC_011900.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 1994508 tkt 7327999 tkt Streptococcus pneumoniae ATCC 700669 transketolase YP_002511902.1 1992532 R 561276 CDS YP_002511903.1 221232749 7329177 complement(1994622..1995713) 1 NC_011900.1 L-ascorbate 6-phosphate lactonase 1995713 7329177 SPN23F_20520 Streptococcus pneumoniae ATCC 700669 L-ascorbate 6-phosphate lactonase YP_002511903.1 1994622 R 561276 CDS YP_002511904.1 221232750 7328000 complement(1995825..1997498) 1 NC_011900.1 transcriptional antiterminator 1997498 7328000 SPN23F_20530 Streptococcus pneumoniae ATCC 700669 transcriptional antiterminator YP_002511904.1 1995825 R 561276 CDS YP_002511905.1 221232751 7328001 complement(1997677..1998381) 1 NC_011900.1 catalyzes the formation of D-xylulose 5-phosphate from L-ribulose 5-phosphate in the L-arabinose and L-ascorbate degradation pathways; L-ribulose-5-phosphate 4-epimerase 1998381 araD 7328001 araD Streptococcus pneumoniae ATCC 700669 L-ribulose-5-phosphate 4-epimerase YP_002511905.1 1997677 R 561276 CDS YP_002511906.1 221232752 7328004 complement(1999245..1999910) 1 NC_011900.1 catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization; 3-keto-L-gulonate-6-phosphate decarboxylase 1999910 ulaD 7328004 ulaD Streptococcus pneumoniae ATCC 700669 3-keto-L-gulonate-6-phosphate decarboxylase YP_002511906.1 1999245 R 561276 CDS YP_002511907.1 221232753 7328005 complement(1999927..2000412) 1 NC_011900.1 sugar phosphotransferase system (PTS), IIA component 2000412 7328005 SPN23F_20580 Streptococcus pneumoniae ATCC 700669 sugar phosphotransferase system (PTS), IIA component YP_002511907.1 1999927 R 561276 CDS YP_002511908.1 221232754 7328006 complement(2000489..2000770) 1 NC_011900.1 sugar phosphotransferase system (PTS),lactose/cellobiose-specific family, IIB subunit protein 2000770 7328006 SPN23F_20590 Streptococcus pneumoniae ATCC 700669 sugar phosphotransferase system (PTS),lactose/cellobiose-specific family, IIB subunit protein YP_002511908.1 2000489 R 561276 CDS YP_002511909.1 221232755 7328007 complement(2000793..2002250) 1 NC_011900.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC 2002250 7328007 SPN23F_20600 Streptococcus pneumoniae ATCC 700669 PTS system ascorbate-specific transporter subunit IIC YP_002511909.1 2000793 R 561276 CDS YP_002511910.1 221232756 7328008 complement(2002381..2003004) 1 NC_011900.1 hypothetical protein 2003004 7328008 SPN23F_20610 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511910.1 2002381 R 561276 CDS YP_002511911.1 221232757 7328009 complement(2003055..2004041) 1 NC_011900.1 ssDNA-binding protein 2004041 7328009 SPN23F_20620 Streptococcus pneumoniae ATCC 700669 ssDNA-binding protein YP_002511911.1 2003055 R 561276 CDS YP_002511912.1 221232758 7328010 complement(2004060..2004890) 1 NC_011900.1 membrane protein OxaA 1 precursor 2004890 7328010 SPN23F_20630 Streptococcus pneumoniae ATCC 700669 membrane protein OxaA 1 precursor YP_002511912.1 2004060 R 561276 CDS YP_002511913.1 221232759 7328011 complement(2004859..2005230) 1 NC_011900.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 2005230 rnpA 7328011 rnpA Streptococcus pneumoniae ATCC 700669 ribonuclease P YP_002511913.1 2004859 R 561276 CDS YP_002511914.1 221232760 7327465 complement(2005379..2006569) 1 NC_011900.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 2006569 ackA 7327465 ackA Streptococcus pneumoniae ATCC 700669 acetate kinase YP_002511914.1 2005379 R 561276 CDS YP_002511915.1 221232761 7328628 complement(2006620..2007573) 1 NC_011900.1 hypothetical protein 2007573 7328628 SPN23F_20670 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511915.1 2006620 R 561276 CDS YP_002511916.1 221232762 7328013 complement(2008331..2008777) 1 NC_011900.1 hypothetical protein 2008777 7328013 SPN23F_20700 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511916.1 2008331 R 561276 CDS YP_002511917.1 221232763 7328014 complement(2008755..2009216) 1 NC_011900.1 hypothetical protein 2009216 7328014 SPN23F_20710 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511917.1 2008755 R 561276 CDS YP_002511918.1 221232764 7328015 complement(2009179..2009439) 1 NC_011900.1 hypothetical protein 2009439 7328015 SPN23F_20720 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511918.1 2009179 R 561276 CDS YP_002511919.1 221232765 7328016 complement(2009444..2009848) 1 NC_011900.1 competence protein 2009848 7328016 SPN23F_20730 Streptococcus pneumoniae ATCC 700669 competence protein YP_002511919.1 2009444 R 561276 CDS YP_002511920.1 221232766 7328017 complement(2009841..2010167) 1 NC_011900.1 competence protein 2010167 comYC 7328017 comYC Streptococcus pneumoniae ATCC 700669 competence protein YP_002511920.1 2009841 R 561276 CDS YP_002511921.1 221232767 7329213 complement(2010169..2011017) 1 NC_011900.1 competence protein 2011017 7329213 SPN23F_20750 Streptococcus pneumoniae ATCC 700669 competence protein YP_002511921.1 2010169 R 561276 CDS YP_002511922.1 221232768 7328018 complement(2011133..2012074) 1 NC_011900.1 competence protein 2012074 7328018 SPN23F_20760 Streptococcus pneumoniae ATCC 700669 competence protein YP_002511922.1 2011133 R 561276 CDS YP_002511923.1 221232769 7328019 complement(2012150..2012515) 1 NC_011900.1 hypothetical protein 2012515 7328019 SPN23F_20770 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511923.1 2012150 R 561276 CDS YP_002511924.1 221232770 7328020 complement(2012666..2013724) 1 NC_011900.1 zinc-binding alcohol dehydrogenase 2013724 7328020 SPN23F_20780 Streptococcus pneumoniae ATCC 700669 zinc-binding alcohol dehydrogenase YP_002511924.1 2012666 R 561276 CDS YP_002511925.1 221232771 7328021 complement(2013887..2015038) 1 NC_011900.1 N-acetylglucosamine-6-phosphate deacetylase 2015038 7328021 SPN23F_20790 Streptococcus pneumoniae ATCC 700669 N-acetylglucosamine-6-phosphate deacetylase YP_002511925.1 2013887 R 561276 CDS YP_002511926.1 221232772 7328022 complement(2015191..2017008) 1 NC_011900.1 acyltransferase family protein 2017008 7328022 SPN23F_20800 Streptococcus pneumoniae ATCC 700669 acyltransferase family protein YP_002511926.1 2015191 R 561276 CDS YP_002511927.1 221232773 7328023 complement(2017109..2018251) 1 NC_011900.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase 2018251 tgt 7328023 tgt Streptococcus pneumoniae ATCC 700669 queuine tRNA-ribosyltransferase YP_002511927.1 2017109 R 561276 CDS YP_002511928.1 221232774 7329165 2018381..2019238 1 NC_011900.1 hypothetical protein 2019238 7329165 SPN23F_20820 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511928.1 2018381 D 561276 CDS YP_002511929.1 221232775 7328024 complement(2019266..2019910) 1 NC_011900.1 catalyzes the removal of 5-oxoproline from various penultimate amino acid residues except L-proline; pyrrolidone-carboxylate peptidase 2019910 7328024 SPN23F_20830 Streptococcus pneumoniae ATCC 700669 pyrrolidone-carboxylate peptidase YP_002511929.1 2019266 R 561276 CDS YP_002511930.1 221232776 7328025 complement(2020017..2020376) 1 NC_011900.1 hypothetical protein 2020376 7328025 SPN23F_20840 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511930.1 2020017 R 561276 CDS YP_002511931.1 221232777 7328026 complement(2020387..2020812) 1 NC_011900.1 MarR family transcriptional regulator 2020812 7328026 SPN23F_20850 Streptococcus pneumoniae ATCC 700669 MarR family transcriptional regulator YP_002511931.1 2020387 R 561276 CDS YP_002511932.1 221232778 7328027 complement(2021132..2022244) 1 NC_011900.1 hypothetical protein 2022244 7328027 SPN23F_20870 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511932.1 2021132 R 561276 CDS YP_002511933.1 221232779 7328028 complement(2022410..2023030) 1 NC_011900.1 haloacid dehalogenase-like hydrolase 2023030 7328028 SPN23F_20880 Streptococcus pneumoniae ATCC 700669 haloacid dehalogenase-like hydrolase YP_002511933.1 2022410 R 561276 CDS YP_002511934.1 221232780 7328029 complement(2023034..2024314) 1 NC_011900.1 multi antimicrobial extrusion (MATE) family transporter 2024314 7328029 SPN23F_20890 Streptococcus pneumoniae ATCC 700669 multi antimicrobial extrusion (MATE) family transporter YP_002511934.1 2023034 R 561276 CDS YP_002511935.1 221232781 7328030 complement(2024375..2025859) 1 NC_011900.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 2025859 7328030 SPN23F_20900 Streptococcus pneumoniae ATCC 700669 threonine synthase YP_002511935.1 2024375 R 561276 CDS YP_002511936.1 221232782 7328031 complement(2025935..2027212) 1 NC_011900.1 hypothetical protein 2027212 7328031 SPN23F_20910 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511936.1 2025935 R 561276 CDS YP_002511937.1 221232783 7327606 complement(2034124..2035584) 1 NC_011900.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 2035584 gltX 7327606 gltX Streptococcus pneumoniae ATCC 700669 glutamyl-tRNA synthetase YP_002511937.1 2034124 R 561276 CDS YP_002511938.1 221232784 7328612 complement(2035708..2037057) 1 NC_011900.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 2037057 pgi 7328612 pgi Streptococcus pneumoniae ATCC 700669 glucose-6-phosphate isomerase YP_002511938.1 2035708 R 561276 CDS YP_002511939.1 221232785 7327837 complement(2037227..2037916) 1 NC_011900.1 peptidase 2037916 7327837 SPN23F_20970 Streptococcus pneumoniae ATCC 700669 peptidase YP_002511939.1 2037227 R 561276 CDS YP_002511940.1 221232786 7328033 complement(2038055..2039821) 1 NC_011900.1 ABC transporter ATP-binding protein 2039821 7328033 SPN23F_20980 Streptococcus pneumoniae ATCC 700669 ABC transporter ATP-binding protein YP_002511940.1 2038055 R 561276 CDS YP_002511941.1 221232787 7328035 complement(2040612..2042306) 1 NC_011900.1 ABC transporter ATP-binding protein 2042306 7328035 SPN23F_21000 Streptococcus pneumoniae ATCC 700669 ABC transporter ATP-binding protein YP_002511941.1 2040612 R 561276 CDS YP_002511942.1 221232788 7328036 complement(2042453..2044987) 1 NC_011900.1 This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS 2044987 mutS 7328036 mutS Streptococcus pneumoniae ATCC 700669 DNA mismatch repair protein MutS YP_002511942.1 2042453 R 561276 CDS YP_002511943.1 221232789 7328402 complement(2045038..2045484) 1 NC_011900.1 arginine repressor 2045484 argR 7328402 argR Streptococcus pneumoniae ATCC 700669 arginine repressor YP_002511943.1 2045038 R 561276 CDS YP_002511944.1 221232790 7328656 2045620..2047311 1 NC_011900.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 2047311 argS 7328656 argS Streptococcus pneumoniae ATCC 700669 arginyl-tRNA synthetase YP_002511944.1 2045620 D 561276 CDS YP_002511945.1 221232791 7328037 2048160..2048636 1 NC_011900.1 hypothetical protein 2048636 7328037 SPN23F_21060 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511945.1 2048160 D 561276 CDS YP_002511946.1 221232792 7328038 2048720..2049427 1 NC_011900.1 alkaline phosphatase synthesis transcriptional regulatory protein 2049427 phoP 7328038 phoP Streptococcus pneumoniae ATCC 700669 alkaline phosphatase synthesis transcriptional regulatory protein YP_002511946.1 2048720 D 561276 CDS YP_002511947.1 221232793 7327844 2049428..2050759 1 NC_011900.1 alkaline phosphatase synthesis sensor protein 2050759 phoR 7327844 phoR Streptococcus pneumoniae ATCC 700669 alkaline phosphatase synthesis sensor protein YP_002511947.1 2049428 D 561276 CDS YP_002511948.1 221232794 7327845 2050926..2051801 1 NC_011900.1 lipoprotein 2051801 7327845 SPN23F_21090 Streptococcus pneumoniae ATCC 700669 lipoprotein YP_002511948.1 2050926 D 561276 CDS YP_002511949.1 221232795 7328039 2051919..2052782 1 NC_011900.1 ABC transporter permease 2052782 7328039 SPN23F_21100 Streptococcus pneumoniae ATCC 700669 ABC transporter permease YP_002511949.1 2051919 D 561276 CDS YP_002511950.1 221232796 7328040 2052775..2053590 1 NC_011900.1 ABC transporter permease 2053590 7328040 SPN23F_21110 Streptococcus pneumoniae ATCC 700669 ABC transporter permease YP_002511950.1 2052775 D 561276 CDS YP_002511951.1 221232797 7328041 2053592..2054344 1 NC_011900.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein 2054344 pstB3 7328041 pstB3 Streptococcus pneumoniae ATCC 700669 phosphate transporter ATP-binding protein YP_002511951.1 2053592 D 561276 CDS YP_002511952.1 221232798 7327887 2054359..2055009 1 NC_011900.1 phosphate transport system protein 2055009 7327887 SPN23F_21130 Streptococcus pneumoniae ATCC 700669 phosphate transport system protein YP_002511952.1 2054359 D 561276 CDS YP_002511953.1 221232799 7328043 complement(2055616..2056056) 1 NC_011900.1 DNA-binding protein 2056056 7328043 SPN23F_21150 Streptococcus pneumoniae ATCC 700669 DNA-binding protein YP_002511953.1 2055616 R 561276 CDS YP_002511954.1 221232800 7328044 2056268..2057284 1 NC_011900.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 2057284 gpsA 7328044 gpsA Streptococcus pneumoniae ATCC 700669 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase YP_002511954.1 2056268 D 561276 CDS YP_002511955.1 221232801 7328620 2057306..2058205 1 NC_011900.1 UTP-glucose-1-phosphate uridylyltransferase 2058205 hasC 7328620 hasC Streptococcus pneumoniae ATCC 700669 UTP-glucose-1-phosphate uridylyltransferase YP_002511955.1 2057306 D 561276 CDS YP_002511956.1 221232802 7328067 complement(2058277..2058954) 1 NC_011900.1 rhomboid family membrane protein 2058954 7328067 SPN23F_21180 Streptococcus pneumoniae ATCC 700669 rhomboid family membrane protein YP_002511956.1 2058277 R 561276 CDS YP_002511957.1 221232803 7328045 complement(2058938..2059477) 1 NC_011900.1 5-formyltetrahydrofolate cyclo-ligase 2059477 7328045 SPN23F_21190 Streptococcus pneumoniae ATCC 700669 5-formyltetrahydrofolate cyclo-ligase YP_002511957.1 2058938 R 561276 CDS YP_002511958.1 221232804 7328046 complement(2059489..2060619) 1 NC_011900.1 peptidase 2060619 7328046 SPN23F_21200 Streptococcus pneumoniae ATCC 700669 peptidase YP_002511958.1 2059489 R 561276 CDS YP_002511959.1 221232805 7328047 complement(2060687..2061385) 1 NC_011900.1 transferase 2061385 7328047 SPN23F_21210 Streptococcus pneumoniae ATCC 700669 transferase YP_002511959.1 2060687 R 561276 CDS YP_002511960.1 221232806 7328048 complement(2061615..2062526) 1 NC_011900.1 hypothetical protein 2062526 7328048 SPN23F_21220 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511960.1 2061615 R 561276 CDS YP_002511961.1 221232807 7328049 complement(2062591..2065056) 1 NC_011900.1 penicillin-binding protein 1B 2065056 pbp1B 7328049 pbp1B Streptococcus pneumoniae ATCC 700669 penicillin-binding protein 1B YP_002511961.1 2062591 R 561276 CDS YP_002511962.1 221232808 7328454 2065198..2066454 1 NC_011900.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 2066454 tyrS 7328454 tyrS Streptococcus pneumoniae ATCC 700669 tyrosyl-tRNA synthetase YP_002511962.1 2065198 D 561276 CDS YP_002511963.1 221232809 7327658 complement(2066532..2068595) 1 NC_011900.1 cation transporting ATPase 2068595 7327658 SPN23F_21250 Streptococcus pneumoniae ATCC 700669 cation transporting ATPase YP_002511963.1 2066532 R 561276 CDS YP_002511964.1 221232810 7328050 complement(2068597..2068875) 1 NC_011900.1 hypothetical protein 2068875 7328050 SPN23F_21260 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511964.1 2068597 R 561276 CDS YP_002511965.1 221232811 7328051 2069027..2069875 1 NC_011900.1 ribosomal RNA large subunit methyltransferase A 2069875 7328051 SPN23F_21270 Streptococcus pneumoniae ATCC 700669 ribosomal RNA large subunit methyltransferase A YP_002511965.1 2069027 D 561276 CDS YP_002511966.1 221232812 7328052 2070497..2071069 1 NC_011900.1 hypothetical protein 2071069 7328052 SPN23F_21290 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511966.1 2070497 D 561276 CDS YP_002511967.1 221232813 7328053 complement(2072113..2074371) 1 NC_011900.1 glycogen phosphorylase 2074371 glgP 7328053 glgP Streptococcus pneumoniae ATCC 700669 glycogen phosphorylase YP_002511967.1 2072113 R 561276 CDS YP_002511968.1 221232814 7328599 complement(2074397..2075914) 1 NC_011900.1 amylomaltase; acts to release glucose from maltodextrins; 4-alpha-glucanotransferase 2075914 malQ 7328599 malQ Streptococcus pneumoniae ATCC 700669 4-alpha-glucanotransferase YP_002511968.1 2074397 R 561276 CDS YP_002511969.1 221232815 7328118 2076464..2077735 1 NC_011900.1 maltose/maltodextrin-binding protein precursor 2077735 malX 7328118 malX Streptococcus pneumoniae ATCC 700669 maltose/maltodextrin-binding protein precursor YP_002511969.1 2076464 D 561276 CDS YP_002511970.1 221232816 7328120 2077846..2079138 1 NC_011900.1 maltose/maltodextrin ABC transport system permease protein 2079138 malC 7328120 malC Streptococcus pneumoniae ATCC 700669 maltose/maltodextrin ABC transport system permease protein YP_002511970.1 2077846 D 561276 CDS YP_002511971.1 221232817 7328116 2079140..2079982 1 NC_011900.1 maltose/maltodextrin ABC transport system permease protein 2079982 malD 7328116 malD Streptococcus pneumoniae ATCC 700669 maltose/maltodextrin ABC transport system permease protein YP_002511971.1 2079140 D 561276 CDS YP_002511972.1 221232818 7328117 2080235..2081035 1 NC_011900.1 maltodextrose utilization protein MalA 2081035 malA 7328117 malA Streptococcus pneumoniae ATCC 700669 maltodextrose utilization protein MalA YP_002511972.1 2080235 D 561276 CDS YP_002511973.1 221232819 7328115 2081045..2082031 1 NC_011900.1 maltose operon transcriptional repressor 2082031 malR 7328115 malR Streptococcus pneumoniae ATCC 700669 maltose operon transcriptional repressor YP_002511973.1 2081045 D 561276 CDS YP_002511974.1 221232820 7328119 complement(2082216..2083472) 1 NC_011900.1 IS1167 transposase 2083472 7328119 SPN23F_21380 Streptococcus pneumoniae ATCC 700669 IS1167 transposase YP_002511974.1 2082216 R 561276 CDS YP_002511975.1 221232821 7328054 2083608..2084153 1 NC_011900.1 May be non-coding repetitive sequence; repetitive protein 2084153 7328054 SPN23F_21390 Streptococcus pneumoniae ATCC 700669 repetitive protein YP_002511975.1 2083608 D 561276 CDS YP_002511976.1 221232822 7328055 complement(2084195..2085136) 1 NC_011900.1 hypothetical protein 2085136 7328055 SPN23F_21400 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511976.1 2084195 R 561276 CDS YP_002511977.1 221232823 7328056 complement(2085114..2086877) 1 NC_011900.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase 2086877 aspS 7328056 aspS Streptococcus pneumoniae ATCC 700669 aspartyl-tRNA synthetase YP_002511977.1 2085114 R 561276 CDS YP_002511978.1 221232824 7328671 complement(2086996..2087232) 1 NC_011900.1 hypothetical protein 2087232 7328671 SPN23F_21420 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511978.1 2086996 R 561276 CDS YP_002511979.1 221232825 7328057 complement(2087274..2087504) 1 NC_011900.1 hypothetical protein 2087504 7328057 SPN23F_21430 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511979.1 2087274 R 561276 CDS YP_002511980.1 221232826 7328058 complement(2087522..2088163) 1 NC_011900.1 May form pseudogene with downstream CDS; CAAX amino terminal protease family membrane protein 2088163 7328058 SPN23F_21440 Streptococcus pneumoniae ATCC 700669 CAAX amino terminal protease family membrane protein YP_002511980.1 2087522 R 561276 CDS YP_002511981.1 221232827 7328303 complement(2088175..2088897) 1 NC_011900.1 hypothetical protein 2088897 7328303 SPN23F_21450 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511981.1 2088175 R 561276 CDS YP_002511982.1 221232828 7328462 complement(2088900..2089097) 1 NC_011900.1 hypothetical protein 2089097 7328462 SPN23F_21460 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511982.1 2088900 R 561276 CDS YP_002511983.1 221232829 7328463 complement(2089097..2089303) 1 NC_011900.1 DNA-binding protein 2089303 7328463 SPN23F_21470 Streptococcus pneumoniae ATCC 700669 DNA-binding protein YP_002511983.1 2089097 R 561276 CDS YP_002511984.1 221232830 7328464 complement(2089313..2089777) 1 NC_011900.1 hypothetical protein 2089777 7328464 SPN23F_21480 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511984.1 2089313 R 561276 CDS YP_002511985.1 221232831 7328465 complement(2089777..2089968) 1 NC_011900.1 hypothetical protein 2089968 7328465 SPN23F_21490 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511985.1 2089777 R 561276 CDS YP_002511986.1 221232832 7328466 complement(2089965..2091254) 1 NC_011900.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase 2091254 hisS 7328466 hisS Streptococcus pneumoniae ATCC 700669 histidyl-tRNA synthetase YP_002511986.1 2089965 R 561276 CDS YP_002511987.1 221232833 7328070 complement(2091332..2092579) 1 NC_011900.1 Major Facilitator Superfamily protein 2092579 7328070 SPN23F_21510 Streptococcus pneumoniae ATCC 700669 Major Facilitator Superfamily protein YP_002511987.1 2091332 R 561276 CDS YP_002511988.1 221232834 7328467 2092796..2094142 1 NC_011900.1 IS4-family transposase 2094142 7328467 SPN23F_21520 Streptococcus pneumoniae ATCC 700669 IS4-family transposase YP_002511988.1 2092796 D 561276 CDS YP_002511989.1 221232835 7328468 complement(2094478..2095329) 1 NC_011900.1 DNA-binding protein 2095329 7328468 SPN23F_21530 Streptococcus pneumoniae ATCC 700669 DNA-binding protein YP_002511989.1 2094478 R 561276 CDS YP_002511990.1 221232836 7328469 complement(2095382..2096335) 1 NC_011900.1 insertion sequence IS1239 transposase 2096335 7328469 SPN23F_21540 Streptococcus pneumoniae ATCC 700669 insertion sequence IS1239 transposase YP_002511990.1 2095382 R 561276 CDS YP_002511991.1 221232837 7328470 2096698..2097039 1 NC_011900.1 hypothetical protein 2097039 7328470 SPN23F_21560 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511991.1 2096698 D 561276 CDS YP_002511992.1 221232838 7328471 complement(2097248..2098951) 1 NC_011900.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase 2098951 ilvD 7328471 ilvD Streptococcus pneumoniae ATCC 700669 dihydroxy-acid dehydratase YP_002511992.1 2097248 R 561276 CDS YP_002511993.1 221232839 7328083 complement(2099184..2100116) 1 NC_011900.1 transketolase subunit 2100116 7328083 SPN23F_21590 Streptococcus pneumoniae ATCC 700669 transketolase subunit YP_002511993.1 2099184 R 561276 CDS YP_002511994.1 221232840 7328472 complement(2100113..2100970) 1 NC_011900.1 transketolase subunit 2100970 7328472 SPN23F_21600 Streptococcus pneumoniae ATCC 700669 transketolase subunit YP_002511994.1 2100113 R 561276 CDS YP_002511995.1 221232841 7328473 complement(2100974..2102320) 1 NC_011900.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC 2102320 ulaA 7328473 ulaA Streptococcus pneumoniae ATCC 700669 PTS system ascorbate-specific transporter subunit IIC YP_002511995.1 2100974 R 561276 CDS YP_002511996.1 221232842 7328474 complement(2102333..2102617) 1 NC_011900.1 sugar phosphotransferase system (PTS),lactose/cellobiose-specific family, IIB subunit protein 2102617 7328474 SPN23F_21620 Streptococcus pneumoniae ATCC 700669 sugar phosphotransferase system (PTS),lactose/cellobiose-specific family, IIB subunit protein YP_002511996.1 2102333 R 561276 CDS YP_002511997.1 221232843 7328475 complement(2102621..2104651) 1 NC_011900.1 PTS multi-domain regulator 2104651 7328475 SPN23F_21630 Streptococcus pneumoniae ATCC 700669 PTS multi-domain regulator YP_002511997.1 2102621 R 561276 CDS YP_002511998.1 221232844 7328476 2104842..2105849 1 NC_011900.1 hypothetical protein 2105849 7328476 SPN23F_21640 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511998.1 2104842 D 561276 CDS YP_002511999.1 221232845 7328477 2105852..2106052 1 NC_011900.1 hypothetical protein 2106052 7328477 SPN23F_21650 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002511999.1 2105852 D 561276 CDS YP_002512000.1 221232846 7328478 2106204..2106386 1 NC_011900.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 2106386 rpmF 7328478 rpmF Streptococcus pneumoniae ATCC 700669 50S ribosomal protein L32 YP_002512000.1 2106204 D 561276 CDS YP_002512001.1 221232847 7327497 2106402..2106551 1 NC_011900.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 2106551 rpmG 7327497 rpmG Streptococcus pneumoniae ATCC 700669 50S ribosomal protein L33 YP_002512001.1 2106402 D 561276 CDS YP_002512002.1 221232848 7327498 2107133..2108389 1 NC_011900.1 transposase 2108389 7327498 SPN23F_21680 Streptococcus pneumoniae ATCC 700669 transposase YP_002512002.1 2107133 D 561276 CDS YP_002512003.1 221232849 7328479 complement(2108466..2110451) 1 NC_011900.1 cell surface choline binding protein PcpA 2110451 pcpA 7328479 pcpA Streptococcus pneumoniae ATCC 700669 cell surface choline binding protein PcpA YP_002512003.1 2108466 R 561276 CDS YP_002512004.1 221232850 7328483 complement(2112435..2114315) 1 NC_011900.1 N-acetyl-beta-D-glucosaminidase 2114315 gcnA 7328483 gcnA Streptococcus pneumoniae ATCC 700669 N-acetyl-beta-D-glucosaminidase YP_002512004.1 2112435 R 561276 CDS YP_002512005.1 221232851 7328590 complement(2114309..2115178) 1 NC_011900.1 ROK family protein 2115178 7328590 SPN23F_21750 Streptococcus pneumoniae ATCC 700669 ROK family protein YP_002512005.1 2114309 R 561276 CDS YP_002512006.1 221232852 7328484 complement(2115262..2117907) 1 NC_011900.1 glycosyl hydrolase 2117907 7328484 SPN23F_21760 Streptococcus pneumoniae ATCC 700669 glycosyl hydrolase YP_002512006.1 2115262 R 561276 CDS YP_002512007.1 221232853 7328485 complement(2117998..2119278) 1 NC_011900.1 hypothetical protein 2119278 7328485 SPN23F_21770 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002512007.1 2117998 R 561276 CDS YP_002512008.1 221232854 7328486 2119449..2121533 1 NC_011900.1 alpha-1,2-mannosidase 2121533 7328486 SPN23F_21780 Streptococcus pneumoniae ATCC 700669 alpha-1,2-mannosidase YP_002512008.1 2119449 D 561276 CDS YP_002512009.1 221232855 7328487 complement(2121573..2123252) 1 NC_011900.1 fucosidase 2123252 7328487 SPN23F_21790 Streptococcus pneumoniae ATCC 700669 fucosidase YP_002512009.1 2121573 R 561276 CDS YP_002512010.1 221232856 7328488 2124008..2125237 1 NC_011900.1 catalyzes the degradation of arginine to citruline and ammonia; arginine deiminase 2125237 arcA 7328488 arcA Streptococcus pneumoniae ATCC 700669 arginine deiminase YP_002512010.1 2124008 D 561276 CDS YP_002512011.1 221232857 7328652 2125295..2126311 1 NC_011900.1 catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway; ornithine carbamoyltransferase 2126311 arcB 7328652 arcB Streptococcus pneumoniae ATCC 700669 ornithine carbamoyltransferase YP_002512011.1 2125295 D 561276 CDS YP_002512012.1 221232858 7328653 2126476..2127423 1 NC_011900.1 catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase 2127423 arcC 7328653 arcC Streptococcus pneumoniae ATCC 700669 carbamate kinase YP_002512012.1 2126476 D 561276 CDS YP_002512013.1 221232859 7328654 2127634..2129145 1 NC_011900.1 C4-dicarboxylate anaerobic carrier protein 2129145 7328654 SPN23F_21830 Streptococcus pneumoniae ATCC 700669 C4-dicarboxylate anaerobic carrier protein YP_002512013.1 2127634 D 561276 CDS YP_002512014.1 221232860 7328489 2129167..2130498 1 NC_011900.1 hypothetical protein 2130498 7328489 SPN23F_21840 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002512014.1 2129167 D 561276 CDS YP_002512015.1 221232861 7328493 complement(2131831..2132730) 1 NC_011900.1 hypothetical protein 2132730 7328493 SPN23F_21880 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002512015.1 2131831 R 561276 CDS YP_002512016.1 221232862 7328494 complement(2132860..2134011) 1 NC_011900.1 alcohol dehydrogenase 2134011 7328494 SPN23F_21890 Streptococcus pneumoniae ATCC 700669 alcohol dehydrogenase YP_002512016.1 2132860 R 561276 CDS YP_002512017.1 221232863 7328495 complement(2134157..2135923) 1 NC_011900.1 catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose; L-fucose isomerase 2135923 fucI 7328495 fucI Streptococcus pneumoniae ATCC 700669 L-fucose isomerase YP_002512017.1 2134157 R 561276 CDS YP_002512018.1 221232864 7328576 complement(2135980..2139096) 1 NC_011900.1 exported glycosyl hydrolase 2139096 7328576 SPN23F_21910 Streptococcus pneumoniae ATCC 700669 exported glycosyl hydrolase YP_002512018.1 2135980 R 561276 CDS YP_002512019.1 221232865 7328496 complement(2139106..2141400) 1 NC_011900.1 hypothetical protein 2141400 7328496 SPN23F_21920 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002512019.1 2139106 R 561276 CDS YP_002512020.1 221232866 7328497 complement(2141459..2142259) 1 NC_011900.1 PTS system, IId component 2142259 7328497 SPN23F_21930 Streptococcus pneumoniae ATCC 700669 PTS system, IId component YP_002512020.1 2141459 R 561276 CDS YP_002512021.1 221232867 7328498 complement(2142256..2143029) 1 NC_011900.1 PTS system, IIc component 2143029 7328498 SPN23F_21940 Streptococcus pneumoniae ATCC 700669 PTS system, IIc component YP_002512021.1 2142256 R 561276 CDS YP_002512022.1 221232868 7328499 complement(2143054..2143524) 1 NC_011900.1 PTS system, mannose-specific IIAB component 2143524 7328499 SPN23F_21950 Streptococcus pneumoniae ATCC 700669 PTS system, mannose-specific IIAB component YP_002512022.1 2143054 R 561276 CDS YP_002512023.1 221232869 7328500 complement(2143515..2143958) 1 NC_011900.1 PTS system, IIa component 2143958 7328500 SPN23F_21960 Streptococcus pneumoniae ATCC 700669 PTS system, IIa component YP_002512023.1 2143515 R 561276 CDS YP_002512024.1 221232870 7328501 complement(2143939..2144379) 1 NC_011900.1 fuscose operon fucU protein 2144379 fucU 7328501 fucU Streptococcus pneumoniae ATCC 700669 fuscose operon fucU protein YP_002512024.1 2143939 R 561276 CDS YP_002512025.1 221232871 7328578 complement(2144391..2145029) 1 NC_011900.1 catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate; L-fuculose phosphate aldolase 2145029 fucA 7328578 fucA Streptococcus pneumoniae ATCC 700669 L-fuculose phosphate aldolase YP_002512025.1 2144391 R 561276 CDS YP_002512026.1 221232872 7328575 complement(2145144..2146547) 1 NC_011900.1 fuculokinase 2146547 fucK 7328575 fucK Streptococcus pneumoniae ATCC 700669 fuculokinase YP_002512026.1 2145144 R 561276 CDS YP_002512027.1 221232873 7328577 2146723..2147496 1 NC_011900.1 fucose phosphotransferase system repressor 2147496 7328577 SPN23F_22000 Streptococcus pneumoniae ATCC 700669 fucose phosphotransferase system repressor YP_002512027.1 2146723 D 561276 CDS YP_002512028.1 221232874 7328502 complement(2148625..2150130) 1 NC_011900.1 zinc-binding protein AdcA precursor 2150130 adcA 7328502 adcA Streptococcus pneumoniae ATCC 700669 zinc-binding protein AdcA precursor YP_002512028.1 2148625 R 561276 CDS YP_002512029.1 221232875 7328633 complement(2150140..2150946) 1 NC_011900.1 ABC transporter permease 2150946 7328633 SPN23F_22020 Streptococcus pneumoniae ATCC 700669 ABC transporter permease YP_002512029.1 2150140 R 561276 CDS YP_002512030.1 221232876 7328503 complement(2150939..2151643) 1 NC_011900.1 ABC transporter ATP-binding protein 2151643 7328503 SPN23F_22030 Streptococcus pneumoniae ATCC 700669 ABC transporter ATP-binding protein YP_002512030.1 2150939 R 561276 CDS YP_002512031.1 221232877 7328504 complement(2151643..2152083) 1 NC_011900.1 MarR family transcriptional regulator 2152083 7328504 SPN23F_22040 Streptococcus pneumoniae ATCC 700669 MarR family transcriptional regulator YP_002512031.1 2151643 R 561276 CDS YP_002512032.1 221232878 7328505 complement(2152238..2153506) 1 NC_011900.1 D-alanyl-lipoteichoic acid biosynthesis protein 2153506 dltD 7328505 dltD Streptococcus pneumoniae ATCC 700669 D-alanyl-lipoteichoic acid biosynthesis protein YP_002512032.1 2152238 R 561276 CDS YP_002512033.1 221232879 7329236 complement(2153499..2153738) 1 NC_011900.1 D-alanyl carrier protein subunit; involved in the incorporation of D-alanine into membrane-associated D-alanyl-lipoteichoic acid; D-alanyl carrier protein is the acceptor of activated D-alanine which it donates to a membrane acceptor(D-alanyl transferase) for incorporation into membrane lipoteichoic acid; D-alanine--poly(phosphoribitol) ligase subunit 2 2153738 dltC 7329236 dltC Streptococcus pneumoniae ATCC 700669 D-alanine--poly(phosphoribitol) ligase subunit 2 YP_002512033.1 2153499 R 561276 CDS YP_002512034.1 221232880 7329235 complement(2153752..2154996) 1 NC_011900.1 activated D-alanine transport protein 2154996 dltB 7329235 dltB Streptococcus pneumoniae ATCC 700669 activated D-alanine transport protein YP_002512034.1 2153752 R 561276 CDS YP_002512035.1 221232881 7329234 complement(2154993..2156543) 1 NC_011900.1 transfers D-alanine to the D-alanyl carrier protein during the incorporation of D-alanine into lipoteichoic acid; D-alanine--poly(phosphoribitol) ligase subunit 1 2156543 dltA 7329234 dltA Streptococcus pneumoniae ATCC 700669 D-alanine--poly(phosphoribitol) ligase subunit 1 YP_002512035.1 2154993 R 561276 CDS YP_002512036.1 221232882 7329233 complement(2156564..2156695) 1 NC_011900.1 hypothetical protein 2156695 7329233 SPN23F_22100 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002512036.1 2156564 R 561276 CDS YP_002512037.1 221232883 7328506 complement(2157009..2157914) 1 NC_011900.1 major facilitator family transport protein 2157914 7328506 SPN23F_22110 Streptococcus pneumoniae ATCC 700669 major facilitator family transport protein YP_002512037.1 2157009 R 561276 CDS YP_002512038.1 221232884 7328508 2161027..2161614 1 NC_011900.1 hypothetical protein 2161614 7328508 SPN23F_22150 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002512038.1 2161027 D 561276 CDS YP_002512039.1 221232885 7328509 complement(2161701..2161904) 1 NC_011900.1 May be affected by BOX element. May be truncated.; hypothetical protein 2161904 7328509 SPN23F_22160 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002512039.1 2161701 R 561276 CDS YP_002512040.1 221232886 7328510 complement(2162201..2162905) 1 NC_011900.1 glycerol uptake facilitator protein 1 2162905 glpF1 7328510 glpF1 Streptococcus pneumoniae ATCC 700669 glycerol uptake facilitator protein 1 YP_002512040.1 2162201 R 561276 CDS YP_002512041.1 221232887 7328608 complement(2162975..2164801) 1 NC_011900.1 alpha-glycerophosphate oxidase 2164801 glpO 7328608 glpO Streptococcus pneumoniae ATCC 700669 alpha-glycerophosphate oxidase YP_002512041.1 2162975 R 561276 CDS YP_002512042.1 221232888 7328610 complement(2164843..2166351) 1 NC_011900.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase 2166351 glpK 7328610 glpK Streptococcus pneumoniae ATCC 700669 glycerol kinase YP_002512042.1 2164843 R 561276 CDS YP_002512043.1 221232889 7328609 complement(2166510..2167919) 1 NC_011900.1 DNA-binding protein 2167919 7328609 SPN23F_22210 Streptococcus pneumoniae ATCC 700669 DNA-binding protein YP_002512043.1 2166510 R 561276 CDS YP_002512044.1 221232890 7328511 2168102..2168974 1 NC_011900.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; Hsp33-like chaperonin 2168974 hslO 7328511 hslO Streptococcus pneumoniae ATCC 700669 Hsp33-like chaperonin YP_002512044.1 2168102 D 561276 CDS YP_002512045.1 221232891 7328512 2168961..2169941 1 NC_011900.1 tRNA-dihydrouridine synthase 2169941 7328512 SPN23F_22230 Streptococcus pneumoniae ATCC 700669 tRNA-dihydrouridine synthase YP_002512045.1 2168961 D 561276 CDS YP_002512046.1 221232892 7328513 complement(2170171..2172795) 1 NC_011900.1 choline-binding surface protein A 2172795 cbpA 7328513 cbpA Streptococcus pneumoniae ATCC 700669 choline-binding surface protein A YP_002512046.1 2170171 R 561276 CDS YP_002512047.1 221232893 7328861 complement(2172874..2173401) 1 NC_011900.1 isoprenylcysteine carboxyl methyltransferase (ICMT) family protein 2173401 7328861 SPN23F_22250 Streptococcus pneumoniae ATCC 700669 isoprenylcysteine carboxyl methyltransferase (ICMT) family protein YP_002512047.1 2172874 R 561276 CDS YP_002512048.1 221232894 7328514 complement(2173496..2174827) 1 NC_011900.1 two-component system, sensor histidine kinase 2174827 7328514 SPN23F_22260 Streptococcus pneumoniae ATCC 700669 two-component system, sensor histidine kinase YP_002512048.1 2173496 R 561276 CDS YP_002512049.1 221232895 7328515 complement(2174824..2175477) 1 NC_011900.1 two-component system, response regulator 2175477 7328515 SPN23F_22270 Streptococcus pneumoniae ATCC 700669 two-component system, response regulator YP_002512049.1 2174824 R 561276 CDS YP_002512050.1 221232896 7328516 complement(2175798..2178230) 1 NC_011900.1 stress response-related Clp ATPase 2178230 clpC 7328516 clpC Streptococcus pneumoniae ATCC 700669 stress response-related Clp ATPase YP_002512050.1 2175798 R 561276 CDS YP_002512051.1 221232897 7329195 complement(2178232..2178690) 1 NC_011900.1 transcriptional regulator 2178690 ctsR 7329195 ctsR Streptococcus pneumoniae ATCC 700669 transcriptional regulator YP_002512051.1 2178232 R 561276 CDS YP_002512052.1 221232898 7329216 complement(2178809..2179537) 1 NC_011900.1 ABC transporter ATP-binding protein 2179537 7329216 SPN23F_22300 Streptococcus pneumoniae ATCC 700669 ABC transporter ATP-binding protein YP_002512052.1 2178809 R 561276 CDS YP_002512053.1 221232899 7328517 complement(2179537..2180544) 1 NC_011900.1 ABC transporter substrate-binding protein 2180544 7328517 SPN23F_22310 Streptococcus pneumoniae ATCC 700669 ABC transporter substrate-binding protein YP_002512053.1 2179537 R 561276 CDS YP_002512054.1 221232900 7328518 complement(2180583..2181299) 1 NC_011900.1 ABC transporter permease 2181299 7328518 SPN23F_22320 Streptococcus pneumoniae ATCC 700669 ABC transporter permease YP_002512054.1 2180583 R 561276 CDS YP_002512055.1 221232901 7328519 complement(2181304..2181594) 1 NC_011900.1 hypothetical protein 2181594 7328519 SPN23F_22330 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002512055.1 2181304 R 561276 CDS YP_002512056.1 221232902 7329486 complement(2181850..2183196) 1 NC_011900.1 choline binding protein D 2183196 cbpD 7329486 cbpD Streptococcus pneumoniae ATCC 700669 choline binding protein D YP_002512056.1 2181850 R 561276 CDS YP_002512057.1 221232903 7329181 complement(2183285..2183551) 1 NC_011900.1 hypothetical protein 2183551 veg 7329181 veg Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002512057.1 2183285 R 561276 CDS YP_002512058.1 221232904 7329428 complement(2183553..2184905) 1 NC_011900.1 unwinds double stranded DNA; replicative DNA helicase 2184905 dnaC 7329428 dnaC Streptococcus pneumoniae ATCC 700669 replicative DNA helicase YP_002512058.1 2183553 R 561276 CDS YP_002512059.1 221232905 7329239 complement(2184949..2185401) 1 NC_011900.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 2185401 rplI 7329239 rplI Streptococcus pneumoniae ATCC 700669 50S ribosomal protein L9 YP_002512059.1 2184949 R 561276 CDS YP_002512060.1 221232906 7327476 complement(2185398..2187371) 1 NC_011900.1 DHH family protein 2187371 7327476 SPN23F_22380 Streptococcus pneumoniae ATCC 700669 DHH family protein YP_002512060.1 2185398 R 561276 CDS YP_002512061.1 221232907 7328521 complement(2187507..2188055) 1 NC_011900.1 sigma 54 modulation protein / S30EA ribosomal protein 2188055 7328521 SPN23F_22390 Streptococcus pneumoniae ATCC 700669 sigma 54 modulation protein / S30EA ribosomal protein YP_002512061.1 2187507 R 561276 CDS YP_002512062.1 221232908 7328522 complement(2188135..2188797) 1 NC_011900.1 late competence protein 2188797 comFC 7328522 comFC Streptococcus pneumoniae ATCC 700669 late competence protein YP_002512062.1 2188135 R 561276 CDS YP_002512063.1 221232909 7329210 complement(2188794..2190092) 1 NC_011900.1 late competence protein 2190092 comFA 7329210 comFA Streptococcus pneumoniae ATCC 700669 late competence protein YP_002512063.1 2188794 R 561276 CDS YP_002512064.1 221232910 7329209 2190148..2190783 1 NC_011900.1 hypothetical protein 2190783 7329209 SPN23F_22420 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002512064.1 2190148 D 561276 CDS YP_002512065.1 221232911 7328523 2191068..2191988 1 NC_011900.1 cysteine synthase 2191988 cysM 7328523 cysM Streptococcus pneumoniae ATCC 700669 cysteine synthase YP_002512065.1 2191068 D 561276 CDS YP_002512066.1 221232912 7328526 complement(2193606..2194646) 1 NC_011900.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 2194646 tsf 7328526 tsf Streptococcus pneumoniae ATCC 700669 elongation factor Ts YP_002512066.1 2193606 R 561276 CDS YP_002512067.1 221232913 7327655 complement(2194725..2195504) 1 NC_011900.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 2195504 rpsB 7327655 rpsB Streptococcus pneumoniae ATCC 700669 30S ribosomal protein S2 YP_002512067.1 2194725 R 561276 CDS YP_002512068.1 221232914 7329109 complement(2195728..2196906) 1 NC_011900.1 amidase 2196906 7329109 SPN23F_22490 Streptococcus pneumoniae ATCC 700669 amidase YP_002512068.1 2195728 R 561276 CDS YP_002512069.1 221232915 7328527 complement(2197000..2197494) 1 NC_011900.1 hypothetical protein 2197494 7328527 SPN23F_22500 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002512069.1 2197000 R 561276 CDS YP_002512070.1 221232916 7328528 complement(2197494..2198312) 1 NC_011900.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall; rod shape-determining protein MreC 2198312 mreC 7328528 mreC Streptococcus pneumoniae ATCC 700669 rod shape-determining protein MreC YP_002512070.1 2197494 R 561276 CDS YP_002512071.1 221232917 7328133 complement(2198371..2199165) 1 NC_011900.1 cobalt transport protein 2199165 7328133 SPN23F_22520 Streptococcus pneumoniae ATCC 700669 cobalt transport protein YP_002512071.1 2198371 R 561276 CDS YP_002512072.1 221232918 7328529 complement(2199158..2199997) 1 NC_011900.1 with CbiNQ forms the ABC transporter for cobalt import; Streptococcus has two adjacent copies of this gene; cobalt transporter ATP-binding subunit 2199997 cbiO 7328529 cbiO Streptococcus pneumoniae ATCC 700669 cobalt transporter ATP-binding subunit YP_002512072.1 2199158 R 561276 CDS YP_002512073.1 221232919 7328530 complement(2199982..2200809) 1 NC_011900.1 with CbiNQ forms the ABC transporter for cobalt import; Streptococcus has two adjacent copies of this gene; cobalt transporter ATP-binding subunit 2200809 cbiO 7328530 cbiO Streptococcus pneumoniae ATCC 700669 cobalt transporter ATP-binding subunit YP_002512073.1 2199982 R 561276 CDS YP_002512074.1 221232920 7328531 complement(2200806..2201351) 1 NC_011900.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 2201351 pgsA 7328531 pgsA Streptococcus pneumoniae ATCC 700669 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase YP_002512074.1 2200806 R 561276 CDS YP_002512075.1 221232921 7327840 complement(2201362..2202183) 1 NC_011900.1 hypothetical protein 2202183 7327840 SPN23F_22560 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002512075.1 2201362 R 561276 CDS YP_002512076.1 221232922 7328532 complement(2202225..2203508) 1 NC_011900.1 protease 2203508 7328532 SPN23F_22570 Streptococcus pneumoniae ATCC 700669 protease YP_002512076.1 2202225 R 561276 CDS YP_002512077.1 221232923 7328533 complement(2203505..2204755) 1 NC_011900.1 protease 2204755 7328533 SPN23F_22580 Streptococcus pneumoniae ATCC 700669 protease YP_002512077.1 2203505 R 561276 CDS YP_002512078.1 221232924 7328534 2204914..2205282 1 NC_011900.1 hypothetical protein 2205282 7328534 SPN23F_22590 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002512078.1 2204914 D 561276 CDS YP_002512079.1 221232925 7328535 2205285..2206382 1 NC_011900.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 2206382 recF 7328535 recF Streptococcus pneumoniae ATCC 700669 recombination protein F YP_002512079.1 2205285 D 561276 CDS YP_002512080.1 221232926 7327443 complement(2206434..2207912) 1 NC_011900.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase 2207912 guaB 7327443 guaB Streptococcus pneumoniae ATCC 700669 inosine 5'-monophosphate dehydrogenase YP_002512080.1 2206434 R 561276 CDS YP_002512081.1 221232927 7328064 complement(2208064..2209089) 1 NC_011900.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase II 2209089 trsA 7328064 trsA Streptococcus pneumoniae ATCC 700669 tryptophanyl-tRNA synthetase II YP_002512081.1 2208064 R 561276 CDS YP_002512082.1 221232928 7327652 2209295..2210917 1 NC_011900.1 ABC transporter ATP-binding protein 2210917 7327652 SPN23F_22630 Streptococcus pneumoniae ATCC 700669 ABC transporter ATP-binding protein YP_002512082.1 2209295 D 561276 CDS YP_002512083.1 221232929 7328536 2210979..2213531 1 NC_011900.1 hypothetical protein 2213531 7328536 SPN23F_22640 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002512083.1 2210979 D 561276 CDS YP_002512084.1 221232930 7328537 complement(2214036..2214311) 1 NC_011900.1 hypothetical protein 2214311 7328537 SPN23F_22650 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002512084.1 2214036 R 561276 CDS YP_002512085.1 221232931 7328538 complement(2214396..2215109) 1 NC_011900.1 hypothetical protein 2215109 7328538 SPN23F_22660 Streptococcus pneumoniae ATCC 700669 hypothetical protein YP_002512085.1 2214396 R 561276 CDS YP_002512086.1 221232932 7328539 2215342..2215884 1 NC_011900.1 TetR family transcriptional regulator 2215884 7328539 SPN23F_22670 Streptococcus pneumoniae ATCC 700669 TetR family transcriptional regulator YP_002512086.1 2215342 D 561276 CDS YP_002512087.1 221232933 7327607 complement(2216127..2216879) 1 NC_011900.1 response regulator protein 2216879 7327607 SPN23F_22680 Streptococcus pneumoniae ATCC 700669 response regulator protein YP_002512087.1 2216127 R 561276 CDS YP_002512088.1 221232934 7328543 complement(2216876..2218201) 1 NC_011900.1 sensor histidine kinase 2218201 7328543 SPN23F_22690 Streptococcus pneumoniae ATCC 700669 sensor histidine kinase YP_002512088.1 2216876 R 561276 CDS YP_002512089.1 221232935 7328623 complement(2218222..2218347) 1 NC_011900.1 competence-stimulating peptide type 2 precursor (csp-2) 2218347 comC2 7328623 comC2 Streptococcus pneumoniae ATCC 700669 competence-stimulating peptide type 2 precursor (csp-2) YP_002512089.1 2218222 R 561276 CDS YP_002512090.1 221232936 7327595 complement(2218629..2219108) 1 NC_011900.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase 2219108 7327595 SPN23F_22710 Streptococcus pneumoniae ATCC 700669 rRNA large subunit methyltransferase YP_002512090.1 2218629 R 561276 CDS YP_002512091.1 221232937 7328624 2219291..2220472 1 NC_011900.1 serine protease 2220472 htrA 7328624 htrA Streptococcus pneumoniae ATCC 700669 serine protease YP_002512091.1 2219291 D 561276 CDS YP_002512092.1 221232938 7328078 2220530..2221288 1 NC_011900.1 chromosome partitioning protein ParB 2221288 parB 7328078 parB Streptococcus pneumoniae ATCC 700669 chromosome partitioning protein ParB YP_002512092.1 2220530 D 561276 CDS