-- dump date 20140620_084416 -- class Genbank::misc_feature -- table misc_feature_note -- id note 561276000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 561276000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 561276000003 Walker A motif; other site 561276000004 ATP binding site [chemical binding]; other site 561276000005 Walker B motif; other site 561276000006 arginine finger; other site 561276000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 561276000008 DnaA box-binding interface [nucleotide binding]; other site 561276000013 DNA polymerase III subunit beta; Validated; Region: PRK05643 561276000014 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 561276000015 putative DNA binding surface [nucleotide binding]; other site 561276000016 dimer interface [polypeptide binding]; other site 561276000017 beta-clamp/clamp loader binding surface; other site 561276000018 beta-clamp/translesion DNA polymerase binding surface; other site 561276000022 Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864 561276000024 GTP-binding protein YchF; Reviewed; Region: PRK09601 561276000025 YchF GTPase; Region: YchF; cd01900 561276000026 G1 box; other site 561276000027 GTP/Mg2+ binding site [chemical binding]; other site 561276000028 Switch I region; other site 561276000029 G2 box; other site 561276000030 Switch II region; other site 561276000031 G3 box; other site 561276000032 G4 box; other site 561276000033 G5 box; other site 561276000034 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 561276000038 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 561276000039 putative active site [active] 561276000040 catalytic residue [active] 561276000043 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 561276000044 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 561276000045 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 561276000046 ATP binding site [chemical binding]; other site 561276000047 putative Mg++ binding site [ion binding]; other site 561276000048 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 561276000049 nucleotide binding region [chemical binding]; other site 561276000050 ATP-binding site [chemical binding]; other site 561276000051 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 561276000058 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 561276000059 RNA binding surface [nucleotide binding]; other site 561276000061 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 561276000062 1 transmembrane helix predicted for SPN23F00080 by TMHMM2.0 at aa 31-53 561276000064 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 561276000065 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 561276000066 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 561276000067 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 561276000068 Ligand Binding Site [chemical binding]; other site 561276000069 TilS substrate C-terminal domain; Region: TilS_C; smart00977 561276000071 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 561276000072 active site 561276000074 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 561276000075 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 561276000076 Walker A motif; other site 561276000077 ATP binding site [chemical binding]; other site 561276000078 Walker B motif; other site 561276000079 arginine finger; other site 561276000080 Peptidase family M41; Region: Peptidase_M41; pfam01434 561276000081 2 transmembrane helices predicted for SPN23F00130 by TMHMM2.0 at aa 13-32 and 133-155 561276000087 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 561276000088 Transposase; Region: DDE_Tnp_ISL3; pfam01610 561276000090 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 561276000094 IS1167 transposase (pseudogene) 561276000095 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 561276000096 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 561276000097 GDP-binding site [chemical binding]; other site 561276000098 ACT binding site; other site 561276000099 IMP binding site; other site 561276000103 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 561276000104 nucleoside/Zn binding site; other site 561276000105 dimer interface [polypeptide binding]; other site 561276000106 catalytic motif [active] 561276000109 Prophage remnant 561276000110 Prophage remnant 561276000111 phage integrase (pseudogene) 561276000113 Uncharacterized conserved protein [Function unknown]; Region: COG4748 561276000114 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 561276000116 Domain of unknown function (DUF955); Region: DUF955; pfam06114 561276000118 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 561276000120 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 561276000121 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 561276000122 non-specific DNA binding site [nucleotide binding]; other site 561276000123 salt bridge; other site 561276000124 sequence-specific DNA binding site [nucleotide binding]; other site 561276000126 phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111 561276000127 YjzC-like protein; Region: YjzC; pfam14168 561276000128 Appears to be truncated; peptidoglycan hydrolytic amidase (pseudogene) 561276000133 Similar to one differently annotated in another pneumo genome; membrane protein (pseudogene) 561276000134 1 transmembrane helix predicted for SPN23F00370 by TMHMM2.0 at aa 10-29 561276000135 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 561276000136 trimer interface [polypeptide binding]; other site 561276000137 active site 561276000139 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 561276000140 catalytic core [active] 561276000142 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 561276000143 DNA repair protein RadA; Provisional; Region: PRK11823 561276000144 Walker A motif; other site 561276000145 ATP binding site [chemical binding]; other site 561276000146 Walker B motif; other site 561276000147 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 561276000149 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 561276000150 active site clefts [active] 561276000151 zinc binding site [ion binding]; other site 561276000152 dimer interface [polypeptide binding]; other site 561276000154 Frameshift mutation relative to orthologue in TIGR4; TIGR4 orthologue likely to also be a pseudogene due to an independent frameshift mutation in the upstream region; membrane protein (pseudogene) 561276000155 6 transmembrane helices predicted for SPN23F00430 by TMHMM2.0 at aa 7-25, 35-57, 70-92, 112-134,141-161 and 181-203 561276000156 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269 561276000157 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 561276000158 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 561276000159 active site 561276000164 coordinates determined manually using correlation scores plot; uncharacterized protein (pseudogene) 561276000165 coordinates determined manually using correlation scores plot; uncharacterized protein (pseudogene) 561276000166 DNA polymerase I; Provisional; Region: PRK05755 561276000167 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 561276000168 active site 561276000169 metal binding site 1 [ion binding]; metal-binding site 561276000170 putative 5' ssDNA interaction site; other site 561276000171 metal binding site 3; metal-binding site 561276000172 metal binding site 2 [ion binding]; metal-binding site 561276000173 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 561276000174 putative DNA binding site [nucleotide binding]; other site 561276000175 putative metal binding site [ion binding]; other site 561276000176 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 561276000177 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 561276000178 active site 561276000179 DNA binding site [nucleotide binding] 561276000180 catalytic site [active] 561276000185 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 561276000187 seems to be truncated; hypothetical protein (pseudogene) 561276000188 Predicted membrane protein [Function unknown]; Region: COG2855 561276000191 aromatic amino acid aminotransferase; Validated; Region: PRK07309 561276000192 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 561276000193 pyridoxal 5'-phosphate binding site [chemical binding]; other site 561276000194 homodimer interface [polypeptide binding]; other site 561276000195 catalytic residue [active] 561276000198 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 561276000199 Recombination protein O N terminal; Region: RecO_N; pfam11967 561276000200 Recombination protein O C terminal; Region: RecO_C; pfam02565 561276000202 putative phosphate acyltransferase; Provisional; Region: PRK05331 561276000205 IS1381 transposase (pseudogene) 561276000206 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 561276000207 1 transmembrane helix predicted for SPN23F00570 by TMHMM2.0 at aa 51-73 561276000208 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 561276000209 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 561276000210 putative active site [active] 561276000211 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 561276000212 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 561276000213 Walker A/P-loop; other site 561276000214 ATP binding site [chemical binding]; other site 561276000215 Q-loop/lid; other site 561276000216 ABC transporter signature motif; other site 561276000217 Walker B; other site 561276000218 D-loop; other site 561276000219 H-loop/switch region; other site 561276000221 5 transmembrane helices predicted for SPN23F00590 by TMHMM2.0 at aa 17-36, 167-189, 202-224,278-300 and 307-326 561276000226 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 561276000227 HlyD family secretion protein; Region: HlyD_3; pfam13437 561276000228 1 transmembrane helix predicted for SPN23F00600 by TMHMM2.0 at aa 19-41 561276000229 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 561276000230 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 561276000231 ATP binding site [chemical binding]; other site 561276000232 active site 561276000233 substrate binding site [chemical binding]; other site 561276000237 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 561276000238 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 561276000239 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 561276000240 dimerization interface [polypeptide binding]; other site 561276000241 ATP binding site [chemical binding]; other site 561276000242 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 561276000243 dimerization interface [polypeptide binding]; other site 561276000244 ATP binding site [chemical binding]; other site 561276000245 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 561276000246 putative active site [active] 561276000247 catalytic triad [active] 561276000251 amidophosphoribosyltransferase; Provisional; Region: PRK07272 561276000252 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 561276000253 active site 561276000254 tetramer interface [polypeptide binding]; other site 561276000255 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 561276000256 active site 561276000261 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 561276000262 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 561276000263 dimerization interface [polypeptide binding]; other site 561276000264 putative ATP binding site [chemical binding]; other site 561276000267 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 561276000268 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 561276000269 active site 561276000270 substrate binding site [chemical binding]; other site 561276000271 cosubstrate binding site; other site 561276000272 catalytic site [active] 561276000274 VanZ like family; Region: VanZ; pfam04892 561276000275 5 transmembrane helices predicted for SPN23F00660 by TMHMM2.0 at aa 7-25, 58-80, 87-109, 119-138 and 145-167 561276000278 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 561276000279 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 561276000280 purine monophosphate binding site [chemical binding]; other site 561276000281 dimer interface [polypeptide binding]; other site 561276000282 putative catalytic residues [active] 561276000283 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 561276000284 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 561276000287 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 561276000288 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 561276000289 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 561276000290 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 561276000295 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 561276000297 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 561276000298 ATP-grasp domain; Region: ATP-grasp; pfam02222 561276000300 AAA domain; Region: AAA_13; pfam13166 561276000301 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 561276000302 Walker A/P-loop; other site 561276000303 ATP binding site [chemical binding]; other site 561276000304 Q-loop/lid; other site 561276000306 adenylosuccinate lyase; Provisional; Region: PRK07492 561276000307 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 561276000308 tetramer interface [polypeptide binding]; other site 561276000309 active site 561276000312 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 561276000313 N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525 561276000314 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 561276000315 active site 561276000316 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 561276000317 active site 561276000318 G5 domain; Region: G5; pfam07501 561276000319 G5 domain; Region: G5; pfam07501 561276000320 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 561276000328 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 561276000329 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 561276000330 DNA-binding site [nucleotide binding]; DNA binding site 561276000331 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 561276000334 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 561276000335 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 561276000337 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 561276000338 active site 561276000339 phosphorylation site [posttranslational modification] 561276000341 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 561276000343 7 transmembrane helices predicted for SPN23F00770 by TMHMM2.0 at aa 20-42, 49-71, 91-113,140-162, 182-204, 217-239 and 259-276 561276000344 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 561276000346 5 transmembrane helices predicted for SPN23F00780 by TMHMM2.0 at aa 102-124, 128-150, 182-204,219-241 and 248-270 561276000347 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 561276000348 active pocket/dimerization site; other site 561276000349 active site 561276000351 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 561276000352 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 561276000353 dimer interface [polypeptide binding]; other site 561276000354 active site 561276000355 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 561276000356 putative active site [active] 561276000359 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 561276000360 active site 561276000361 catalytic residues [active] 561276000364 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 561276000365 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 561276000366 putative metal binding site [ion binding]; other site 561276000367 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 561276000368 active site 561276000372 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cl00846 561276000373 putative homodimer interface [polypeptide binding]; other site 561276000374 putative homotetramer interface [polypeptide binding]; other site 561276000375 putative allosteric switch controlling residues; other site 561276000376 putative metal binding site [ion binding]; other site 561276000377 putative homodimer-homodimer interface [polypeptide binding]; other site 561276000379 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 561276000380 active site residue [active] 561276000382 Similar to C-terminus of a protein from other streptococci 561276000383 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 561276000385 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 561276000386 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 561276000387 10 transmembrane helices predicted for SPN23F00890 by TMHMM2.0 at aa 23-45, 55-77, 84-106,134-156, 161-183, 198-219, 239-258, 318-340, 360-382 and 417-439 561276000389 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 561276000390 TrkA-N domain; Region: TrkA_N; pfam02254 561276000392 glycosyl transferase (pseudogene) 561276000394 cell wall surface anchor family protein (pseudogene) 561276000397 1 transmembrane helix predicted for SPN23F00940 by TMHMM2.0 at aa 493-515 561276000398 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 561276000399 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 561276000400 active site 561276000401 phosphorylation site [posttranslational modification] 561276000402 intermolecular recognition site; other site 561276000403 dimerization interface [polypeptide binding]; other site 561276000404 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 561276000405 DNA binding site [nucleotide binding] 561276000408 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 561276000409 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 561276000410 dimerization interface [polypeptide binding]; other site 561276000411 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 561276000412 dimer interface [polypeptide binding]; other site 561276000413 phosphorylation site [posttranslational modification] 561276000414 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 561276000415 ATP binding site [chemical binding]; other site 561276000416 Mg2+ binding site [ion binding]; other site 561276000417 G-X-G motif; other site 561276000418 2 transmembrane helices predicted for SPN23F00960 by TMHMM2.0 at aa 7-26 and 36-58 561276000422 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 561276000423 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 561276000424 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 561276000425 RNA binding surface [nucleotide binding]; other site 561276000429 IS630-Spn1 transposase (pseudogene) 561276000431 IS-Spn2 transposase (pseudogene) 561276000432 hypothetical protein (pseudogene) 561276000433 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 561276000434 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 561276000435 dimer interface [polypeptide binding]; other site 561276000436 conserved gate region; other site 561276000437 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 561276000438 ABC-ATPase subunit interface; other site 561276000439 6 transmembrane helices predicted for SPN23F01020 by TMHMM2.0 at aa 12-34, 82-104, 117-139,159-181, 214-236 and 276-298 561276000442 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 561276000443 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 561276000444 dimer interface [polypeptide binding]; other site 561276000445 conserved gate region; other site 561276000446 putative PBP binding loops; other site 561276000447 ABC-ATPase subunit interface; other site 561276000448 6 transmembrane helices predicted for SPN23F01030 by TMHMM2.0 at aa 26-48, 83-105, 122-144,154-176, 197-219 and 275-297 561276000451 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 561276000452 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 561276000453 1 transmembrane helix predicted for SPN23F01040 by TMHMM2.0 at aa 7-29 561276000456 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 561276000457 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 561276000458 active site residue [active] 561276000459 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 561276000461 Domain of unknown function (DUF4299); Region: DUF4299; pfam14132 561276000462 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 561276000463 1 transmembrane helix predicted for SPN23F01080 by TMHMM2.0 at aa 7-29 561276000464 Predicted membrane protein [Function unknown]; Region: COG4709 561276000466 Predicted transcriptional regulators [Transcription]; Region: COG1695 561276000467 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 561276000469 Major Facilitator Superfamily protein (pseudogene) 561276000471 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 561276000472 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 561276000473 Ligand binding site; other site 561276000475 3 transmembrane helices predicted for SPN23F01130 by TMHMM2.0 at aa 280-302, 304-326 and 336-358 561276000476 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 561276000477 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 561276000478 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 561276000479 NAD(P) binding site [chemical binding]; other site 561276000480 homodimer interface [polypeptide binding]; other site 561276000481 substrate binding site [chemical binding]; other site 561276000482 active site 561276000483 4 transmembrane helices predicted for SPN23F01140 by TMHMM2.0 at aa 24-46, 56-78, 91-113 and 117-136 561276000486 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 561276000487 Transposase; Region: DDE_Tnp_ISL3; pfam01610 561276000489 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 561276000490 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 561276000491 active site 561276000492 motif I; other site 561276000493 motif II; other site 561276000495 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 561276000496 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 561276000498 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 561276000499 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 561276000500 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 561276000501 putative L-serine binding site [chemical binding]; other site 561276000504 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 561276000505 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 561276000506 1 transmembrane helix predicted for SPN23F01200 by TMHMM2.0 at aa 12-29 561276000508 Very similar to SPN23F01201; both appear to encode the C terminal fragments of a conserved hypothetical protein, on the basis of comparisons to S. pneumoniae OXC141; hypothetical protein (pseudogene) 561276000509 bacteriocin, lactococcin 972 family; Region: lactococcin_972; TIGR01653 561276000510 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 561276000511 8 transmembrane helices predicted for SPN23F01210 by TMHMM2.0 at aa 7-26, 196-215, 246-265,275-297, 317-339, 598-620, 641-660 and 664-686 561276000512 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 561276000513 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 561276000514 Walker A/P-loop; other site 561276000515 ATP binding site [chemical binding]; other site 561276000516 Q-loop/lid; other site 561276000517 ABC transporter signature motif; other site 561276000518 Walker B; other site 561276000519 D-loop; other site 561276000520 H-loop/switch region; other site 561276000524 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 561276000525 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 561276000526 substrate binding pocket [chemical binding]; other site 561276000527 membrane-bound complex binding site; other site 561276000528 hinge residues; other site 561276000533 Very similar to SPN23F01241; both appear to encode the C terminal fragments of a conserved hypothetical protein, on the basis of comparisons to S. pneumoniae OXC141; hypothetical protein (pseudogene) 561276000534 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 561276000535 Transposase; Region: DDE_Tnp_ISL3; pfam01610 561276000537 membrane protein (pseudogene) 561276000538 1 transmembrane helix predicted for SPN23F01260 by TMHMM2.0 at aa 33-55 561276000539 8 transmembrane helices predicted for SPN23F01270 by TMHMM2.0 at aa 12-27, 32-49, 56-75, 85-104,130-152, 156-178, 190-209 and 213-230 561276000541 pneumococcal surface protein PspA (pseudogene) 561276000542 1 transmembrane helix predicted for SPN23F01290 by TMHMM2.0 at aa 7-29 561276000554 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 561276000555 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 561276000558 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 561276000559 nudix motif; other site 561276000562 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 561276000563 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 561276000564 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 561276000568 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 561276000569 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 561276000570 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 561276000574 hypothetical protein; Provisional; Region: PRK13667 561276000576 competence-induced protein ccs1 (pseudogene) 561276000577 1 transmembrane helix predicted for SPN23F01370 by TMHMM2.0 at aa 21-38 561276000578 class IIb bacteriocin, lactobin A/cerein 7B family; Region: bact_IIb_cerein; TIGR03949 561276000579 1 transmembrane helix predicted for SPN23F01380 by TMHMM2.0 at aa 38-60 561276000580 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 561276000581 Glycoprotease family; Region: Peptidase_M22; pfam00814 561276000583 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 561276000584 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 561276000585 Coenzyme A binding pocket [chemical binding]; other site 561276000587 UGMP family protein; Validated; Region: PRK09604 561276000588 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 561276000589 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 561276000592 transposase (pseudogene) 561276000593 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 561276000594 Helix-turn-helix domain; Region: HTH_38; pfam13936 561276000595 Transposase; Region: DDE_Tnp_ISL3; pfam01610 561276000597 transposase (pseudogene) 561276000598 glycosyl transferase (pseudogene) 561276000599 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 561276000600 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 561276000601 active site 561276000603 1 transmembrane helix predicted for SPN23F01460 by TMHMM2.0 at aa 285-307 561276000604 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 561276000605 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 561276000606 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 561276000607 Walker A/P-loop; other site 561276000608 ATP binding site [chemical binding]; other site 561276000609 Q-loop/lid; other site 561276000610 ABC transporter signature motif; other site 561276000611 Walker B; other site 561276000612 D-loop; other site 561276000613 H-loop/switch region; other site 561276000614 5 transmembrane helices predicted for SPN23F01470 by TMHMM2.0 at aa 13-32, 52-69, 127-144,149-171 and 237-259 561276000622 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 561276000624 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 561276000625 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 561276000626 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 561276000629 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 561276000630 non-specific DNA binding site [nucleotide binding]; other site 561276000631 salt bridge; other site 561276000632 sequence-specific DNA binding site [nucleotide binding]; other site 561276000633 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 561276000634 CAAX protease self-immunity; Region: Abi; pfam02517 561276000635 7 transmembrane helices predicted for SPN23F01530 by TMHMM2.0 at aa 5-27, 42-64, 77-99, 114-136,155-172, 176-195 and 200-219 561276000637 9 transmembrane helices predicted for SPN23F01540 by TMHMM2.0 at aa 13-32, 42-64, 85-107,168-190, 230-252, 267-289, 302-324, 353-375 and 382-404 561276000638 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 561276000640 5 transmembrane helices predicted for SPN23F01550 by TMHMM2.0 at aa 5-27, 47-69, 120-142, 146-165 and 177-199 561276000641 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 561276000642 2 transmembrane helices predicted for SPN23F01560 by TMHMM2.0 at aa 5-27 and 40-59 561276000644 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 561276000645 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 561276000646 substrate binding pocket [chemical binding]; other site 561276000647 membrane-bound complex binding site; other site 561276000648 hinge residues; other site 561276000649 1 transmembrane helix predicted for SPN23F01570 by TMHMM2.0 at aa 7-29 561276000653 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 561276000654 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 561276000657 hypothetical protein; Provisional; Region: PRK06446 561276000658 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 561276000659 metal binding site [ion binding]; metal-binding site 561276000660 dimer interface [polypeptide binding]; other site 561276000663 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 561276000664 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 561276000665 Walker A/P-loop; other site 561276000666 ATP binding site [chemical binding]; other site 561276000667 Q-loop/lid; other site 561276000668 ABC transporter signature motif; other site 561276000669 Walker B; other site 561276000670 D-loop; other site 561276000671 H-loop/switch region; other site 561276000672 NIL domain; Region: NIL; pfam09383 561276000676 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 561276000678 5 transmembrane helices predicted for SPN23F01610 by TMHMM2.0 at aa 32-54, 75-97, 101-118,169-191 and 201-223 561276000679 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 561276000680 Predicted integral membrane protein [Function unknown]; Region: COG5578 561276000681 5 transmembrane helices predicted for SPN23F01630 by TMHMM2.0 at aa 12-34, 72-94, 101-123,143-165 and 167-186 561276000683 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 561276000684 HAMP domain; Region: HAMP; pfam00672 561276000685 Histidine kinase; Region: His_kinase; pfam06580 561276000686 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 561276000687 ATP binding site [chemical binding]; other site 561276000688 Mg2+ binding site [ion binding]; other site 561276000689 G-X-G motif; other site 561276000690 1 transmembrane helix predicted for SPN23F01640 by TMHMM2.0 at aa 231-253 561276000694 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753 561276000695 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 561276000696 active site 561276000697 phosphorylation site [posttranslational modification] 561276000698 intermolecular recognition site; other site 561276000699 dimerization interface [polypeptide binding]; other site 561276000700 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 561276000704 4 transmembrane helices predicted for SPN23F01660 by TMHMM2.0 at aa 5-27, 67-89, 96-118 and 133-155 561276000705 flavoprotein NrdI; Provisional; Region: PRK02551 561276000707 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 561276000708 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 561276000709 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 561276000710 LytTr DNA-binding domain; Region: LytTR; smart00850 561276000712 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 561276000713 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 561276000714 ATP binding site [chemical binding]; other site 561276000715 Mg2+ binding site [ion binding]; other site 561276000716 G-X-G motif; other site 561276000717 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 561276000718 ATP binding site [chemical binding]; other site 561276000719 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 561276000724 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 561276000725 homopentamer interface [polypeptide binding]; other site 561276000726 active site 561276000728 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 561276000729 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 561276000730 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 561276000731 dimerization interface [polypeptide binding]; other site 561276000732 active site 561276000735 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 561276000736 Lumazine binding domain; Region: Lum_binding; pfam00677 561276000737 Lumazine binding domain; Region: Lum_binding; pfam00677 561276000741 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 561276000742 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 561276000743 catalytic motif [active] 561276000744 Zn binding site [ion binding]; other site 561276000745 RibD C-terminal domain; Region: RibD_C; cl17279 561276000749 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 561276000750 RuvA N terminal domain; Region: RuvA_N; pfam01330 561276000753 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 561276000755 CAAX protease self-immunity; Region: Abi; pfam02517 561276000756 7 transmembrane helices predicted for SPN23F01780 by TMHMM2.0 at aa 9-31, 35-52, 71-93, 122-144,151-168, 173-195 and 202-224 561276000758 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 561276000759 putative dimer interface [polypeptide binding]; other site 561276000760 catalytic triad [active] 561276000762 Uncharacterized membrane-bound protein conserved in bacteria [Function unknown]; Region: COG4858 561276000764 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 561276000765 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 561276000766 Cl binding site [ion binding]; other site 561276000767 oligomer interface [polypeptide binding]; other site 561276000769 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 561276000770 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 561276000771 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 561276000772 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 561276000779 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 561276000780 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 561276000781 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 561276000782 active site 561276000786 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 561276000787 ArsC family; Region: ArsC; pfam03960 561276000788 putative catalytic residues [active] 561276000789 thiol/disulfide switch; other site 561276000792 hypothetical protein; Provisional; Region: PRK05473 561276000794 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 561276000796 hypothetical protein; Provisional; Region: PRK13678 561276000798 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 561276000799 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 561276000803 Bacterial lipoprotein; Region: DUF3642; pfam12182 561276000805 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 561276000806 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 561276000807 Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154 561276000808 putative active site [active] 561276000809 catalytic site [active] 561276000810 Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160 561276000811 putative active site [active] 561276000812 catalytic site [active] 561276000813 3 transmembrane helices predicted for SPN23F01910 by TMHMM2.0 at aa 13-35, 40-59 and 68-87 561276000816 9 transmembrane helices predicted for SPN23F01920 by TMHMM2.0 at aa 39-61, 98-120, 140-174,194-216, 223-245, 278-300, 307-329, 333-352 and 372-394 561276000817 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 561276000818 ATP cone domain; Region: ATP-cone; pfam03477 561276000819 Class III ribonucleotide reductase; Region: RNR_III; cd01675 561276000820 effector binding site; other site 561276000821 active site 561276000822 Zn binding site [ion binding]; other site 561276000823 glycine loop; other site 561276000827 Predicted acetyltransferase [General function prediction only]; Region: COG3981 561276000828 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 561276000830 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 561276000831 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 561276000832 FeS/SAM binding site; other site 561276000834 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 561276000835 active site 561276000838 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 561276000841 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 561276000844 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 561276000846 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 561276000849 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 561276000850 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 561276000851 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 561276000855 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 561276000858 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 561276000859 putative translocon binding site; other site 561276000860 protein-rRNA interface [nucleotide binding]; other site 561276000863 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 561276000864 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 561276000865 G-X-X-G motif; other site 561276000866 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 561276000871 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 561276000872 23S rRNA interface [nucleotide binding]; other site 561276000873 5S rRNA interface [nucleotide binding]; other site 561276000874 putative antibiotic binding site [chemical binding]; other site 561276000875 L25 interface [polypeptide binding]; other site 561276000876 L27 interface [polypeptide binding]; other site 561276000880 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 561276000881 23S rRNA interface [nucleotide binding]; other site 561276000882 putative translocon interaction site; other site 561276000883 signal recognition particle (SRP54) interaction site; other site 561276000884 L23 interface [polypeptide binding]; other site 561276000885 trigger factor interaction site; other site 561276000887 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 561276000890 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 561276000893 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 561276000894 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 561276000895 RNA binding site [nucleotide binding]; other site 561276000898 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 561276000899 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 561276000900 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 561276000904 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 561276000907 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 561276000910 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 561276000911 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 561276000912 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 561276000916 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 561276000917 5S rRNA interface [nucleotide binding]; other site 561276000918 L27 interface [polypeptide binding]; other site 561276000919 23S rRNA interface [nucleotide binding]; other site 561276000920 L5 interface [polypeptide binding]; other site 561276000922 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 561276000923 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 561276000924 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 561276000928 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 561276000929 23S rRNA binding site [nucleotide binding]; other site 561276000932 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 561276000936 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 561276000937 SecY translocase; Region: SecY; pfam00344 561276000938 10 transmembrane helices predicted for SPN23F02190 by TMHMM2.0 at aa 20-42, 68-85, 117-139,149-168, 180-202, 212-234, 270-292, 307-329, 366-388 and 398-416 561276000942 adenylate kinase; Reviewed; Region: adk; PRK00279 561276000943 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 561276000944 AMP-binding site [chemical binding]; other site 561276000945 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 561276000949 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 561276000950 rRNA binding site [nucleotide binding]; other site 561276000951 predicted 30S ribosome binding site; other site 561276000953 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 561276000954 30S ribosomal protein S13; Region: bact_S13; TIGR03631 561276000957 30S ribosomal protein S11; Validated; Region: PRK05309 561276000960 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 561276000961 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 561276000962 alphaNTD homodimer interface [polypeptide binding]; other site 561276000963 alphaNTD - beta interaction site [polypeptide binding]; other site 561276000964 alphaNTD - beta' interaction site [polypeptide binding]; other site 561276000965 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 561276000969 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 561276000972 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 561276000974 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 561276000976 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 561276000977 catalytic core [active] 561276000978 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 561276000980 putative PBP binding loops; other site 561276000981 dimer interface [polypeptide binding]; other site 561276000982 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 561276000983 ABC-ATPase subunit interface; other site 561276000984 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 561276000985 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 561276000986 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 561276000987 dimer interface [polypeptide binding]; other site 561276000988 conserved gate region; other site 561276000989 ABC-ATPase subunit interface; other site 561276000991 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 561276000992 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 561276000993 Walker A/P-loop; other site 561276000994 ATP binding site [chemical binding]; other site 561276000995 Q-loop/lid; other site 561276000996 ABC transporter signature motif; other site 561276000997 Walker B; other site 561276000998 D-loop; other site 561276000999 H-loop/switch region; other site 561276001000 TOBE domain; Region: TOBE_2; pfam08402 561276001006 Appears to have been disrupted through the insertion of a RUP element; extracellular solute-binding protein (pseudogene) 561276001007 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 561276001008 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 561276001009 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 561276001012 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 561276001013 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 561276001014 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 561276001018 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 561276001019 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 561276001021 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 561276001022 active site 561276001023 methionine cluster; other site 561276001024 phosphorylation site [posttranslational modification] 561276001025 metal binding site [ion binding]; metal-binding site 561276001027 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 561276001028 active site 561276001029 P-loop; other site 561276001030 phosphorylation site [posttranslational modification] 561276001032 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 561276001033 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 561276001034 10 transmembrane helices predicted for SPN23F02400 by TMHMM2.0 at aa 21-43, 69-91, 98-120,135-157, 186-208, 223-245, 292-311, 321-343, 350-372 and 395-417 561276001036 Pyruvate-formate lyase [Energy production and conversion]; Region: PflD; COG1882 561276001037 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 561276001038 dimer interface [polypeptide binding]; other site 561276001039 active site 561276001040 glycine loop; other site 561276001044 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 561276001045 active site 561276001046 intersubunit interactions; other site 561276001047 catalytic residue [active] 561276001050 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 561276001051 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 561276001052 dimer interface [polypeptide binding]; other site 561276001053 active site 561276001054 metal binding site [ion binding]; metal-binding site 561276001058 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 561276001059 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 561276001060 HIGH motif; other site 561276001061 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 561276001062 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 561276001063 active site 561276001064 KMSKS motif; other site 561276001065 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 561276001066 tRNA binding surface [nucleotide binding]; other site 561276001070 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 561276001071 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 561276001073 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 561276001074 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 561276001075 Coenzyme A binding pocket [chemical binding]; other site 561276001077 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 561276001078 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 561276001079 Walker A motif; other site 561276001080 ATP binding site [chemical binding]; other site 561276001081 Walker B motif; other site 561276001082 arginine finger; other site 561276001083 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 561276001088 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3575 561276001090 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 561276001091 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 561276001092 catalytic residue [active] 561276001093 putative FPP diphosphate binding site; other site 561276001094 putative FPP binding hydrophobic cleft; other site 561276001095 dimer interface [polypeptide binding]; other site 561276001096 putative IPP diphosphate binding site; other site 561276001099 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 561276001100 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 561276001102 7 transmembrane helices predicted for SPN23F02500 by TMHMM2.0 at aa 10-41, 48-70, 85-104,111-128, 138-160, 173-194 and 198-220 561276001104 RIP metalloprotease RseP; Region: TIGR00054 561276001105 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 561276001106 active site 561276001107 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 561276001108 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 561276001109 putative substrate binding region [chemical binding]; other site 561276001110 5 transmembrane helices predicted for SPN23F02510 by TMHMM2.0 at aa 4-26, 169-191, 290-312,345-367 and 389-411 561276001113 prolyl-tRNA synthetase; Provisional; Region: PRK09194 561276001114 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 561276001115 dimer interface [polypeptide binding]; other site 561276001116 motif 1; other site 561276001117 active site 561276001118 motif 2; other site 561276001119 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 561276001120 putative deacylase active site [active] 561276001121 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 561276001122 active site 561276001123 motif 3; other site 561276001124 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 561276001125 anticodon binding site; other site 561276001130 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 561276001131 beta-galactosidase; Region: BGL; TIGR03356 561276001134 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 561276001135 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 561276001136 glutaminase active site [active] 561276001137 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 561276001138 dimer interface [polypeptide binding]; other site 561276001139 active site 561276001140 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 561276001141 dimer interface [polypeptide binding]; other site 561276001142 active site 561276001147 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 561276001148 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 561276001150 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 561276001151 pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102 561276001152 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 561276001153 carbohydrate binding site [chemical binding]; other site 561276001154 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 561276001155 carbohydrate binding site [chemical binding]; other site 561276001156 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 561276001157 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 561276001158 Ca binding site [ion binding]; other site 561276001159 active site 561276001160 catalytic site [active] 561276001167 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 561276001168 S17 interaction site [polypeptide binding]; other site 561276001169 S8 interaction site; other site 561276001170 16S rRNA interaction site [nucleotide binding]; other site 561276001171 streptomycin interaction site [chemical binding]; other site 561276001172 23S rRNA interaction site [nucleotide binding]; other site 561276001173 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 561276001176 30S ribosomal protein S7; Validated; Region: PRK05302 561276001179 elongation factor G; Reviewed; Region: PRK00007 561276001180 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 561276001181 G1 box; other site 561276001182 putative GEF interaction site [polypeptide binding]; other site 561276001183 GTP/Mg2+ binding site [chemical binding]; other site 561276001184 Switch I region; other site 561276001185 G2 box; other site 561276001186 G3 box; other site 561276001187 Switch II region; other site 561276001188 G4 box; other site 561276001189 G5 box; other site 561276001190 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 561276001191 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 561276001192 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 561276001199 DNA polymerase III PolC; Validated; Region: polC; PRK00448 561276001200 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 561276001201 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 561276001202 generic binding surface II; other site 561276001203 generic binding surface I; other site 561276001204 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 561276001205 active site 561276001206 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 561276001207 active site 561276001208 catalytic site [active] 561276001209 substrate binding site [chemical binding]; other site 561276001210 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 561276001211 putative PHP Thumb interface [polypeptide binding]; other site 561276001212 active site 561276001217 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 561276001218 Transposase; Region: DDE_Tnp_ISL3; pfam01610 561276001220 addiction module antitoxin, RelB/DinJ family; Region: RelB_DinJ; TIGR02384 561276001223 addiction module toxin (pseudogene) 561276001225 1 transmembrane helix predicted for SPN23F02650 by TMHMM2.0 at aa 25-47 561276001226 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 561276001227 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 561276001229 Predicted membrane protein [Function unknown]; Region: COG2261 561276001230 3 transmembrane helices predicted for SPN23F02670 by TMHMM2.0 at aa 5-19, 26-45 and 50-72 561276001232 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 561276001233 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 561276001234 RNA binding surface [nucleotide binding]; other site 561276001235 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 561276001236 active site 561276001237 uracil binding [chemical binding]; other site 561276001240 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 561276001241 trimer interface [polypeptide binding]; other site 561276001242 active site 561276001243 G bulge; other site 561276001248 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 561276001250 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 561276001252 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 561276001253 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 561276001254 active pocket/dimerization site; other site 561276001255 active site 561276001256 phosphorylation site [posttranslational modification] 561276001257 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 561276001258 active site 561276001259 phosphorylation site [posttranslational modification] 561276001262 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 561276001263 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 561276001264 NAD binding site [chemical binding]; other site 561276001265 substrate binding site [chemical binding]; other site 561276001266 catalytic Zn binding site [ion binding]; other site 561276001267 tetramer interface [polypeptide binding]; other site 561276001268 structural Zn binding site [ion binding]; other site 561276001273 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 561276001274 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 561276001275 active site 561276001276 motif I; other site 561276001277 motif II; other site 561276001280 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 561276001281 Sulfate transporter family; Region: Sulfate_transp; pfam00916 561276001283 11 transmembrane helices predicted for SPN23F02760 by TMHMM2.0 at aa 19-38, 48-70, 77-94, 99-118,130-147, 192-209, 216-238, 348-370, 377-399, 419-441 and 454-471 561276001284 CAAX protease self-immunity; Region: Abi; pfam02517 561276001285 6 transmembrane helices predicted for SPN23F02770 by TMHMM2.0 at aa 17-39, 44-66, 87-109,129-151, 164-186 and 206-228 561276001287 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 561276001288 dihydropteroate synthase; Region: DHPS; TIGR01496 561276001289 substrate binding pocket [chemical binding]; other site 561276001290 dimer interface [polypeptide binding]; other site 561276001291 inhibitor binding site; inhibition site 561276001295 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 561276001296 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 561276001297 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 561276001301 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 561276001302 homodecamer interface [polypeptide binding]; other site 561276001303 GTP cyclohydrolase I; Provisional; Region: PLN03044 561276001304 active site 561276001305 putative catalytic site residues [active] 561276001306 zinc binding site [ion binding]; other site 561276001307 GTP-CH-I/GFRP interaction surface; other site 561276001311 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 561276001312 homooctamer interface [polypeptide binding]; other site 561276001313 active site 561276001314 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 561276001315 catalytic center binding site [active] 561276001316 ATP binding site [chemical binding]; other site 561276001320 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 561276001321 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 561276001322 23S rRNA interface [nucleotide binding]; other site 561276001323 L3 interface [polypeptide binding]; other site 561276001326 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 561276001332 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 561276001333 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 561276001334 putative active site [active] 561276001335 putative catalytic site [active] 561276001337 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 561276001338 catalytic residues [active] 561276001339 dimer interface [polypeptide binding]; other site 561276001343 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 561276001344 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 561276001345 substrate binding site [chemical binding]; other site 561276001346 catalytic residues [active] 561276001353 1 transmembrane helix predicted for SPN23F02890 by TMHMM2.0 at aa 1044-1061 561276001354 transposase (pseudogene) 561276001356 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 561276001357 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 561276001358 active site 561276001359 intersubunit interface [polypeptide binding]; other site 561276001360 catalytic residue [active] 561276001362 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 561276001363 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 561276001364 substrate binding site [chemical binding]; other site 561276001365 ATP binding site [chemical binding]; other site 561276001368 hypothetical protein; Provisional; Region: PRK09273 561276001369 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 561276001370 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 561276001372 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 561276001373 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 561276001374 NADP binding site [chemical binding]; other site 561276001375 homodimer interface [polypeptide binding]; other site 561276001376 active site 561276001379 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 561276001380 active pocket/dimerization site; other site 561276001381 active site 561276001382 phosphorylation site [posttranslational modification] 561276001384 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 561276001386 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 561276001387 active site 561276001388 phosphorylation site [posttranslational modification] 561276001390 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 561276001392 6 transmembrane helices predicted for SPN23F02980 by TMHMM2.0 at aa 5-27, 32-54, 97-119, 140-162,177-199 and 206-237 561276001394 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 561276001396 5 transmembrane helices predicted for SPN23F02990 by TMHMM2.0 at aa 100-122, 137-159, 180-202,227-244 and 249-271 561276001397 Preprotein translocase subunit YajC [Intracellular trafficking and secretion]; Region: YajC; COG1862 561276001399 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 561276001401 Transcriptional regulators [Transcription]; Region: PurR; COG1609 561276001402 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 561276001403 DNA binding site [nucleotide binding] 561276001404 domain linker motif; other site 561276001405 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 561276001406 putative dimerization interface [polypeptide binding]; other site 561276001407 putative ligand binding site [chemical binding]; other site 561276001410 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 561276001411 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 561276001412 non-specific DNA binding site [nucleotide binding]; other site 561276001413 salt bridge; other site 561276001414 sequence-specific DNA binding site [nucleotide binding]; other site 561276001416 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 561276001417 MraW methylase family; Region: Methyltransf_5; pfam01795 561276001420 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 561276001421 1 transmembrane helix predicted for SPN23F03070 by TMHMM2.0 at aa 25-44 561276001422 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 561276001423 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 561276001424 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 561276001425 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 561276001426 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 561276001427 1 transmembrane helix predicted for SPN23F03080 by TMHMM2.0 at aa 29-51 561276001432 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 561276001433 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 561276001434 Mg++ binding site [ion binding]; other site 561276001435 putative catalytic motif [active] 561276001436 putative substrate binding site [chemical binding]; other site 561276001437 10 transmembrane helices predicted for SPN23F03090 by TMHMM2.0 at aa 5-27, 48-70, 80-102, 115-129,144-166, 173-192, 197-214, 221-243, 247-269 and 306-325 561276001439 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 561276001440 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 561276001441 Walker A motif; other site 561276001442 ATP binding site [chemical binding]; other site 561276001443 Walker B motif; other site 561276001444 arginine finger; other site 561276001445 UvrB/uvrC motif; Region: UVR; pfam02151 561276001446 MoxR-like ATPases [General function prediction only]; Region: COG0714 561276001447 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 561276001448 Walker A motif; other site 561276001449 ATP binding site [chemical binding]; other site 561276001450 Walker B motif; other site 561276001451 arginine finger; other site 561276001452 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 561276001457 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 561276001459 LuxS protein involved in autoinducer AI2 synthesis [Signal transduction mechanisms]; Region: LuxS; COG1854 561276001461 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 561276001462 hypothetical protein; Provisional; Region: PRK13663 561276001464 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 561276001465 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 561276001466 Ca binding site [ion binding]; other site 561276001467 active site 561276001468 catalytic site [active] 561276001470 oligopeptide-binding protein fragment (pseudogene) 561276001471 1 transmembrane helix predicted for SPN23F03160 by TMHMM2.0 at aa 7-24 561276001473 IS630-Spn1 transposase (pseudogene) 561276001474 DNA polymerase processivity factor; Region: DNA_PPF; pfam02916 561276001475 Transcriptional regulator [Transcription]; Region: LytR; COG1316 561276001476 3 transmembrane helices predicted for SPN23F03180 by TMHMM2.0 at aa 17-36, 46-68 and 75-97 561276001479 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 561276001481 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 561276001482 polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006 561276001484 1 transmembrane helix predicted for SPN23F03200 by TMHMM2.0 at aa 113-135 561276001486 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 561276001487 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 561276001488 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 561276001489 Bacterial sugar transferase; Region: Bac_transf; pfam02397 561276001490 5 transmembrane helices predicted for SPN23F03220 by TMHMM2.0 at aa 5-27, 32-51, 71-88, 98-117 and 267-289 561276001492 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955 561276001493 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 561276001496 10 transmembrane helices predicted for SPN23F03250 by TMHMM2.0 at aa 7-29, 34-51, 58-80, 90-112,119-141, 156-175, 195-217, 232-254, 321-343 and 368-387 561276001497 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 561276001498 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 561276001499 active site 561276001502 Protein of unknown function (DUF563); Region: DUF563; pfam04577 561276001503 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 561276001504 Polysaccharide biosynthesis protein; Region: Polysacc_synt; pfam01943 561276001505 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 561276001507 12 transmembrane helices predicted for SPN23F03280 by TMHMM2.0 at aa 12-34, 49-71, 78-100,110-132, 141-163, 168-190, 211-228, 243-265, 288-310,325-347, 367-389 and 424-446 561276001509 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 561276001510 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 561276001511 1 transmembrane helix predicted for SPN23F03290 by TMHMM2.0 at aa 9-26 561276001513 Glycerol-1-phosphate dehydrogenase-like; Region: G1PDH-like; cd08174 561276001514 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 561276001515 active site 561276001516 metal binding site [ion binding]; metal-binding site 561276001518 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 561276001519 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 561276001520 active site 561276001521 metal-binding site 561276001523 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 561276001524 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 561276001525 active site 561276001526 motif I; other site 561276001527 motif II; other site 561276001528 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 561276001530 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 561276001531 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 561276001532 substrate binding site; other site 561276001533 tetramer interface; other site 561276001535 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 561276001537 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 561276001538 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 561276001539 NAD binding site [chemical binding]; other site 561276001540 substrate binding site [chemical binding]; other site 561276001541 homodimer interface [polypeptide binding]; other site 561276001542 active site 561276001544 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 561276001545 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 561276001546 NADP binding site [chemical binding]; other site 561276001547 active site 561276001548 putative substrate binding site [chemical binding]; other site 561276001550 transposase (pseudogene) 561276001552 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 561276001553 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 561276001554 peptide binding site [polypeptide binding]; other site 561276001558 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 561276001559 Endo-alpha-N-acetylgalactosaminidase; Region: Glyco_hydro_101; pfam12905 561276001560 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 561276001561 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 561276001563 1 transmembrane helix predicted for SPN23F03400 by TMHMM2.0 at aa 17-39 561276001567 Transglycosylase; Region: Transgly; pfam00912 561276001568 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 561276001569 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 561276001572 1 transmembrane helix predicted for SPN23F03410 by TMHMM2.0 at aa 13-35 561276001573 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 561276001575 hypothetical protein; Provisional; Region: PRK13660 561276001577 cell division protein GpsB; Provisional; Region: PRK14127 561276001578 DivIVA domain; Region: DivI1A_domain; TIGR03544 561276001580 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 561276001581 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 561276001582 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 561276001585 1 transmembrane helix predicted for SPN23F03460 by TMHMM2.0 at aa 159-181 561276001586 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 561276001587 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 561276001588 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 561276001592 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 561276001593 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 561276001594 active site 561276001595 phosphorylation site [posttranslational modification] 561276001596 intermolecular recognition site; other site 561276001597 dimerization interface [polypeptide binding]; other site 561276001598 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 561276001599 DNA binding site [nucleotide binding] 561276001602 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 561276001609 uncharacterized protein (pseudogene) 561276001612 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 561276001613 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 561276001614 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 561276001617 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 561276001618 diphosphomevalonate decarboxylase; Region: PLN02407 561276001622 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 561276001623 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 561276001626 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 561276001627 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 561276001628 homotetramer interface [polypeptide binding]; other site 561276001629 FMN binding site [chemical binding]; other site 561276001630 homodimer contacts [polypeptide binding]; other site 561276001631 putative active site [active] 561276001632 putative substrate binding site [chemical binding]; other site 561276001634 Predicted membrane protein [Function unknown]; Region: COG4758 561276001635 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 561276001636 3 transmembrane helices predicted for SPN23F03570 by TMHMM2.0 at aa 7-24, 29-46 and 59-81 561276001637 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 561276001638 Histidine kinase; Region: HisKA_3; pfam07730 561276001639 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 561276001640 ATP binding site [chemical binding]; other site 561276001641 Mg2+ binding site [ion binding]; other site 561276001642 G-X-G motif; other site 561276001643 2 transmembrane helices predicted for SPN23F03580 by TMHMM2.0 at aa 7-25 and 45-67 561276001646 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 561276001647 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 561276001648 active site 561276001649 phosphorylation site [posttranslational modification] 561276001650 intermolecular recognition site; other site 561276001651 dimerization interface [polypeptide binding]; other site 561276001652 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 561276001653 DNA binding residues [nucleotide binding] 561276001654 dimerization interface [polypeptide binding]; other site 561276001658 DNA alkylation repair enzyme (pseudogene) 561276001662 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 561276001663 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 561276001664 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 561276001668 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 561276001675 IS3-Spn1 orf B (pseudogene) 561276001677 IS3-Spn1 orf A (pseudogene) 561276001678 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 561276001679 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 561276001680 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 561276001681 active site 561276001682 P-loop; other site 561276001683 phosphorylation site [posttranslational modification] 561276001684 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 561276001685 active site 561276001686 P-loop; other site 561276001687 phosphorylation site [posttranslational modification] 561276001689 8 transmembrane helices predicted for SPN23F03700 by TMHMM2.0 at aa 21-40, 50-72, 79-101,135-157, 214-236, 246-265, 270-289 and 316-338 561276001691 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 561276001692 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 561276001693 active site 561276001694 P-loop; other site 561276001695 phosphorylation site [posttranslational modification] 561276001697 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 561276001698 active site 561276001699 phosphorylation site [posttranslational modification] 561276001702 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 561276001703 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 561276001704 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 561276001708 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 561276001709 trigger factor; Provisional; Region: tig; PRK01490 561276001710 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 561276001711 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 561276001715 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 561276001716 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 561276001717 DNA binding site [nucleotide binding] 561276001718 AAA domain; Region: AAA_30; pfam13604 561276001719 Family description; Region: UvrD_C_2; pfam13538 561276001721 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 561276001722 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 561276001723 Catalytic site [active] 561276001724 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 561276001728 1 transmembrane helix predicted for SPN23F03790 by TMHMM2.0 at aa 7-29 561276001729 ribonuclease HIII; Provisional; Region: PRK00996 561276001730 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 561276001731 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 561276001732 RNA/DNA hybrid binding site [nucleotide binding]; other site 561276001733 active site 561276001735 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 561276001736 Colicin V production protein; Region: Colicin_V; pfam02674 561276001738 3 transmembrane helices predicted for SPN23F03820 by TMHMM2.0 at aa 21-43, 79-101 and 121-143 561276001739 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: COG1193 561276001740 MutS domain III; Region: MutS_III; pfam05192 561276001741 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 561276001742 Walker A/P-loop; other site 561276001743 ATP binding site [chemical binding]; other site 561276001744 Q-loop/lid; other site 561276001745 ABC transporter signature motif; other site 561276001746 Walker B; other site 561276001747 D-loop; other site 561276001748 H-loop/switch region; other site 561276001749 Smr domain; Region: Smr; pfam01713 561276001753 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 561276001754 amino acid carrier protein; Region: agcS; TIGR00835 561276001755 11 transmembrane helices predicted for SPN23F03840 by TMHMM2.0 at aa 13-35, 59-81, 91-113,143-162, 177-199, 208-230, 236-258, 304-326, 346-368,381-400 and 410-432 561276001758 Uncharacterized conserved protein [Function unknown]; Region: COG2128 561276001759 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 561276001761 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 561276001762 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 561276001763 gating phenylalanine in ion channel; other site 561276001764 8 transmembrane helices predicted for SPN23F03860 by TMHMM2.0 at aa 5-23, 28-50, 63-85, 95-117,130-152, 206-228, 241-263 and 273-295 561276001766 seryl-tRNA synthetase; Provisional; Region: PRK05431 561276001767 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 561276001768 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 561276001769 dimer interface [polypeptide binding]; other site 561276001770 active site 561276001771 motif 1; other site 561276001772 motif 2; other site 561276001773 motif 3; other site 561276001777 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4687 561276001779 aspartate kinase; Reviewed; Region: PRK09034 561276001780 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 561276001781 putative catalytic residues [active] 561276001782 putative nucleotide binding site [chemical binding]; other site 561276001783 putative aspartate binding site [chemical binding]; other site 561276001784 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 561276001785 allosteric regulatory residue; other site 561276001786 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 561276001790 enoyl-CoA hydratase; Provisional; Region: PRK07260 561276001791 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 561276001792 substrate binding site [chemical binding]; other site 561276001793 oxyanion hole (OAH) forming residues; other site 561276001794 trimer interface [polypeptide binding]; other site 561276001796 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 561276001797 MarR family; Region: MarR_2; pfam12802 561276001799 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 561276001800 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 561276001801 dimer interface [polypeptide binding]; other site 561276001802 active site 561276001803 CoA binding pocket [chemical binding]; other site 561276001806 acyl carrier protein; Provisional; Region: acpP; PRK00982 561276001808 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 561276001809 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 561276001810 FMN binding site [chemical binding]; other site 561276001811 substrate binding site [chemical binding]; other site 561276001812 putative catalytic residue [active] 561276001815 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 561276001816 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 561276001818 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 561276001819 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 561276001820 NAD(P) binding site [chemical binding]; other site 561276001821 homotetramer interface [polypeptide binding]; other site 561276001822 homodimer interface [polypeptide binding]; other site 561276001823 active site 561276001827 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 561276001828 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 561276001829 dimer interface [polypeptide binding]; other site 561276001830 active site 561276001835 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 561276001836 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 561276001837 carboxyltransferase (CT) interaction site; other site 561276001838 biotinylation site [posttranslational modification]; other site 561276001840 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 561276001842 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 561276001843 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 561276001844 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 561276001845 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 561276001851 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 561276001852 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 561276001853 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 561276001855 acetyl-CoA carboxylase subunit alpha; Provisional; Region: PRK12319 561276001857 1 transmembrane helix predicted for SPN23F04040 by TMHMM2.0 at aa 28-47 561276001858 CAAX protease self-immunity; Region: Abi; pfam02517 561276001859 4 transmembrane helices predicted for SPN23F04050 by TMHMM2.0 at aa 10-27, 46-65, 70-89 and 102-124 561276001861 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 561276001862 putative RNA binding site [nucleotide binding]; other site 561276001865 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 561276001867 elongation factor P; Validated; Region: PRK00529 561276001868 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 561276001869 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 561276001870 RNA binding site [nucleotide binding]; other site 561276001871 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 561276001872 RNA binding site [nucleotide binding]; other site 561276001877 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 561276001878 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 561276001879 GatB domain; Region: GatB_Yqey; pfam02637 561276001883 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 561276001884 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 561276001888 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 561276001890 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 561276001891 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 561276001892 G1 box; other site 561276001893 putative GEF interaction site [polypeptide binding]; other site 561276001894 GTP/Mg2+ binding site [chemical binding]; other site 561276001895 Switch I region; other site 561276001896 G2 box; other site 561276001897 G3 box; other site 561276001898 Switch II region; other site 561276001899 G4 box; other site 561276001900 G5 box; other site 561276001901 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 561276001905 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 561276001906 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 561276001907 Ligand binding site; other site 561276001908 metal-binding site 561276001910 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 561276001912 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 561276001914 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 561276001915 DAK2 domain; Region: Dak2; pfam02734 561276001917 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07282 561276001918 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 561276001919 PYR/PP interface [polypeptide binding]; other site 561276001920 dimer interface [polypeptide binding]; other site 561276001921 TPP binding site [chemical binding]; other site 561276001922 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 561276001923 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 561276001924 TPP-binding site [chemical binding]; other site 561276001925 dimer interface [polypeptide binding]; other site 561276001931 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 561276001932 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 561276001933 putative valine binding site [chemical binding]; other site 561276001934 dimer interface [polypeptide binding]; other site 561276001935 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 561276001938 ketol-acid reductoisomerase; Provisional; Region: PRK05479 561276001939 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 561276001940 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 561276001944 hypothetical protein (pseudogene) 561276001945 threonine dehydratase; Validated; Region: PRK08639 561276001946 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 561276001947 tetramer interface [polypeptide binding]; other site 561276001948 pyridoxal 5'-phosphate binding site [chemical binding]; other site 561276001949 catalytic residue [active] 561276001950 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 561276001955 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 561276001956 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 561276001957 Walker A/P-loop; other site 561276001958 ATP binding site [chemical binding]; other site 561276001959 Q-loop/lid; other site 561276001960 ABC transporter signature motif; other site 561276001961 Walker B; other site 561276001962 D-loop; other site 561276001963 H-loop/switch region; other site 561276001967 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 561276001968 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 561276001969 substrate binding pocket [chemical binding]; other site 561276001970 membrane-bound complex binding site; other site 561276001971 hinge residues; other site 561276001972 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 561276001973 dimer interface [polypeptide binding]; other site 561276001974 conserved gate region; other site 561276001975 putative PBP binding loops; other site 561276001976 ABC-ATPase subunit interface; other site 561276001980 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 561276001981 4 transmembrane helices predicted for SPN23F04270 by TMHMM2.0 at aa 5-23, 245-267, 445-467 and 472-494 561276001982 Truncated by an internal deletion relative to some orthologues; transposase (pseudogene) 561276001985 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 561276001987 7 transmembrane helices predicted for SPN23F04300 by TMHMM2.0 at aa 10-32, 45-67, 111-133,154-176, 191-213, 226-248 and 263-280 561276001988 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 561276001989 active site 561276001990 DNA polymerase IV; Validated; Region: PRK02406 561276001991 DNA binding site [nucleotide binding] 561276001993 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 561276001994 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 561276002000 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 561276002001 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 561276002003 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 561276002004 TrkA-N domain; Region: TrkA_N; pfam02254 561276002005 TrkA-C domain; Region: TrkA_C; pfam02080 561276002006 TrkA-N domain; Region: TrkA_N; pfam02254 561276002007 TrkA-C domain; Region: TrkA_C; pfam02080 561276002014 Uncharacterized conserved protein [Function unknown]; Region: COG1912 561276002016 hypothetical protein; Provisional; Region: PRK13661 561276002018 5 transmembrane helices predicted for SPN23F04390 by TMHMM2.0 at aa 10-32, 45-65, 75-97, 109-128 and 148-170 561276002019 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 561276002020 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 561276002021 Walker A/P-loop; other site 561276002022 ATP binding site [chemical binding]; other site 561276002023 Q-loop/lid; other site 561276002024 ABC transporter signature motif; other site 561276002025 Walker B; other site 561276002026 D-loop; other site 561276002027 H-loop/switch region; other site 561276002028 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 561276002029 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 561276002030 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 561276002031 Walker A/P-loop; other site 561276002032 ATP binding site [chemical binding]; other site 561276002033 Q-loop/lid; other site 561276002034 ABC transporter signature motif; other site 561276002035 Walker B; other site 561276002036 D-loop; other site 561276002037 H-loop/switch region; other site 561276002044 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 561276002047 5 transmembrane helices predicted for SPN23F04420 by TMHMM2.0 at aa 13-35, 40-57, 64-86, 114-136 and 247-266 561276002049 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 561276002051 Predicted membrane protein [Function unknown]; Region: COG3601 561276002052 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 561276002053 5 transmembrane helices predicted for SPN23F04440 by TMHMM2.0 at aa 10-32, 39-61, 76-98, 107-129 and 156-178 561276002055 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 561276002056 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 561276002057 active site 561276002058 6 transmembrane helices predicted for SPN23F04450 by TMHMM2.0 at aa 7-25, 57-79, 86-108, 123-145,157-179 and 184-202 561276002061 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 561276002062 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 561276002064 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 561276002066 CTP synthetase; Validated; Region: pyrG; PRK05380 561276002067 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 561276002068 Catalytic site [active] 561276002069 active site 561276002070 UTP binding site [chemical binding]; other site 561276002071 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 561276002072 active site 561276002073 putative oxyanion hole; other site 561276002074 catalytic triad [active] 561276002077 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 561276002078 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 561276002079 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 561276002080 PhoU domain; Region: PhoU; pfam01895 561276002081 PhoU domain; Region: PhoU; pfam01895 561276002086 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 561276002087 Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724 561276002088 Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with...; Region: GH85_ENGase; cd06547 561276002089 putative active site [active] 561276002090 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 561276002091 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 561276002092 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 561276002093 G5 domain; Region: G5; pfam07501 561276002103 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 561276002104 Phosphoglycerate kinase; Region: PGK; pfam00162 561276002105 substrate binding site [chemical binding]; other site 561276002106 hinge regions; other site 561276002107 ADP binding site [chemical binding]; other site 561276002108 catalytic site [active] 561276002111 Predicted membrane protein [Function unknown]; Region: COG4129 561276002112 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 561276002113 5 transmembrane helices predicted for SPN23F04540 by TMHMM2.0 at aa 25-47, 62-84, 91-113, 117-134 and 141-163 561276002114 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 561276002115 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 561276002116 DNA binding residues [nucleotide binding] 561276002117 putative dimer interface [polypeptide binding]; other site 561276002119 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 561276002120 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 561276002121 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 561276002125 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 561276002126 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 561276002127 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 561276002130 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 561276002131 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 561276002132 VanD integrase, IntD, and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases including those similar to IntD, a putative integrase-like protein, a component...; Region: INT_VanD; cd01196 561276002133 Int/Topo IB signature motif; other site 561276002135 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 561276002136 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 561276002137 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 561276002140 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 561276002141 HsdM N-terminal domain; Region: HsdM_N; pfam12161 561276002142 Methyltransferase domain; Region: Methyltransf_26; pfam13659 561276002144 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 561276002145 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 561276002146 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 561276002147 ATP binding site [chemical binding]; other site 561276002148 putative Mg++ binding site [ion binding]; other site 561276002153 2 transmembrane helices predicted for SPN23F04640 by TMHMM2.0 at aa 5-27 and 32-54 561276002154 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 561276002155 2 transmembrane helices predicted for SPN23F04650 by TMHMM2.0 at aa 114-133 and 137-159 561276002156 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 561276002157 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 561276002160 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 561276002161 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 561276002162 dimer interface [polypeptide binding]; other site 561276002163 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 561276002166 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 561276002167 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 561276002168 nucleotide binding site [chemical binding]; other site 561276002169 NEF interaction site [polypeptide binding]; other site 561276002170 SBD interface [polypeptide binding]; other site 561276002175 2 transmembrane helices predicted for SPN23F04690 by TMHMM2.0 at aa 61-83 and 93-115 561276002176 chaperone protein DnaJ; Provisional; Region: PRK14276 561276002177 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 561276002178 HSP70 interaction site [polypeptide binding]; other site 561276002179 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 561276002180 substrate binding site [polypeptide binding]; other site 561276002181 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 561276002182 Zn binding sites [ion binding]; other site 561276002183 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 561276002184 substrate binding site [polypeptide binding]; other site 561276002185 dimer interface [polypeptide binding]; other site 561276002194 PIF1-like helicase; Region: PIF1; pfam05970 561276002195 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 561276002196 HIT family signature motif; other site 561276002197 catalytic residue [active] 561276002200 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 561276002201 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 561276002202 Walker A/P-loop; other site 561276002203 ATP binding site [chemical binding]; other site 561276002204 Q-loop/lid; other site 561276002205 ABC transporter signature motif; other site 561276002206 Walker B; other site 561276002207 D-loop; other site 561276002208 H-loop/switch region; other site 561276002212 Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542 561276002214 8 transmembrane helices predicted for SPN23F04750 by TMHMM2.0 at aa 21-43, 53-75, 103-125,129-148, 229-246, 250-272, 298-317 and 322-341 561276002215 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 561276002216 LytTr DNA-binding domain; Region: LytTR; pfam04397 561276002218 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 561276002219 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 561276002220 active site 561276002221 phosphorylation site [posttranslational modification] 561276002222 intermolecular recognition site; other site 561276002223 dimerization interface [polypeptide binding]; other site 561276002224 LytTr DNA-binding domain; Region: LytTR; pfam04397 561276002227 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 561276002228 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 561276002229 ATP binding site [chemical binding]; other site 561276002230 Mg2+ binding site [ion binding]; other site 561276002231 G-X-G motif; other site 561276002232 6 transmembrane helices predicted for SPN23F04790 by TMHMM2.0 at aa 5-27, 42-64, 84-105, 120-142,163-182 and 192-209 561276002234 COMC family; Region: ComC; pfam03047 561276002235 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 561276002236 HlyD family secretion protein; Region: HlyD_3; pfam13437 561276002237 1 transmembrane helix predicted for SPN23F04800 by TMHMM2.0 at aa 20-42 561276002238 potential frameshift: common BLAST hit: gi|194398624|ref|YP_002037195.1| BlpC ABC transporter ATP-binding protein (blpA) 561276002239 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 561276002240 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 561276002241 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 561276002242 Walker A/P-loop; other site 561276002243 ATP binding site [chemical binding]; other site 561276002244 Q-loop/lid; other site 561276002245 ABC transporter signature motif; other site 561276002246 Walker B; other site 561276002247 D-loop; other site 561276002248 H-loop/switch region; other site 561276002253 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 561276002254 putative active site [active] 561276002256 1 transmembrane helix predicted for SPN23F04830 by TMHMM2.0 at aa 33-55 561276002257 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 561276002258 2 transmembrane helices predicted for SPN23F04840 by TMHMM2.0 at aa 32-54 and 59-81 561276002259 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 561276002260 2 transmembrane helices predicted for SPN23F04850 by TMHMM2.0 at aa 34-51 and 56-78 561276002261 bacteriocin (pseudogene) 561276002262 1 transmembrane helix predicted for SPN23F04870 by TMHMM2.0 at aa 10-32 561276002263 1 transmembrane helix predicted for SPN23F04890 by TMHMM2.0 at aa 12-30 561276002264 2 transmembrane helices predicted for SPN23F04900 by TMHMM2.0 at aa 5-22 and 26-47 561276002265 4 transmembrane helices predicted for SPN23F04910 by TMHMM2.0 at aa 7-26, 30-49, 70-89 and 99-118 561276002266 4 transmembrane helices predicted for SPN23F04930 by TMHMM2.0 at aa 5-27, 32-54, 67-89 and 93-115 561276002267 CAAX protease self-immunity; Region: Abi; pfam02517 561276002268 6 transmembrane helices predicted for SPN23F04940 by TMHMM2.0 at aa 10-29, 41-63, 78-97, 110-132,172-194 and 201-223 561276002270 CAAX protease self-immunity; Region: Abi; pfam02517 561276002271 4 transmembrane helices predicted for SPN23F04950 by TMHMM2.0 at aa 7-27, 37-54, 70-92 and 161-178 561276002273 Phosphotransferase enzyme family; Region: APH; pfam01636 561276002274 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 561276002275 substrate binding site [chemical binding]; other site 561276002277 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 561276002278 S-adenosylmethionine binding site [chemical binding]; other site 561276002280 ribosome maturation protein RimP; Reviewed; Region: PRK00092 561276002281 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 561276002282 putative oligomer interface [polypeptide binding]; other site 561276002283 putative RNA binding site [nucleotide binding]; other site 561276002285 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 561276002286 NusA N-terminal domain; Region: NusA_N; pfam08529 561276002287 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 561276002288 RNA binding site [nucleotide binding]; other site 561276002289 homodimer interface [polypeptide binding]; other site 561276002290 NusA-like KH domain; Region: KH_5; pfam13184 561276002291 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 561276002292 G-X-X-G motif; other site 561276002295 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 561276002296 putative RNA binding cleft [nucleotide binding]; other site 561276002298 hypothetical protein; Provisional; Region: PRK07283 561276002300 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 561276002301 translation initiation factor IF-2; Region: IF-2; TIGR00487 561276002302 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 561276002303 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 561276002304 G1 box; other site 561276002305 putative GEF interaction site [polypeptide binding]; other site 561276002306 GTP/Mg2+ binding site [chemical binding]; other site 561276002307 Switch I region; other site 561276002308 G2 box; other site 561276002309 G3 box; other site 561276002310 Switch II region; other site 561276002311 G4 box; other site 561276002312 G5 box; other site 561276002313 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 561276002314 Translation-initiation factor 2; Region: IF-2; pfam11987 561276002315 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 561276002322 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 561276002324 3 transmembrane helices predicted for SPN23F05040 by TMHMM2.0 at aa 70-92, 134-156 and 203-220 561276002325 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 561276002327 Uncharacterized conserved protein [Function unknown]; Region: COG2461 561276002328 Family of unknown function (DUF438); Region: DUF438; pfam04282 561276002329 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 561276002330 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 561276002331 putative active site [active] 561276002332 heme pocket [chemical binding]; other site 561276002336 Domain of unknown function (DUF1912); Region: DUF1912; pfam08930 561276002338 hypothetical protein; Provisional; Region: PRK07758 561276002339 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 561276002340 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 561276002341 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 561276002342 Coenzyme A binding pocket [chemical binding]; other site 561276002344 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 561276002345 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 561276002346 active site 561276002347 HIGH motif; other site 561276002348 nucleotide binding site [chemical binding]; other site 561276002349 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 561276002350 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 561276002351 active site 561276002352 KMSKS motif; other site 561276002353 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 561276002354 tRNA binding surface [nucleotide binding]; other site 561276002355 anticodon binding site; other site 561276002356 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 561276002360 Domain of unknown function (DUF3883); Region: DUF3883; pfam13020 561276002361 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 561276002362 Fic/DOC family; Region: Fic; pfam02661 561276002363 IS1167 transposase (pseudogene) 561276002365 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4951 561276002366 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 561276002367 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 561276002368 ATP binding site [chemical binding]; other site 561276002369 putative Mg++ binding site [ion binding]; other site 561276002370 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 561276002371 nucleotide binding region [chemical binding]; other site 561276002372 ATP-binding site [chemical binding]; other site 561276002373 C-terminal putative phospholipase D-like domain of uncharacterized prokaryotic HKD family nucleases fused to DEAD/DEAH box helicases; Region: PLDc_C_DEXD_like; cd09126 561276002378 transcriptional antiterminator BglG; Provisional; Region: PRK09772 561276002379 CAT RNA binding domain; Region: CAT_RBD; smart01061 561276002380 PRD domain; Region: PRD; pfam00874 561276002381 PRD domain; Region: PRD; pfam00874 561276002385 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 561276002386 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 561276002387 active site turn [active] 561276002388 phosphorylation site [posttranslational modification] 561276002389 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 561276002390 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 561276002391 HPr interaction site; other site 561276002392 glycerol kinase (GK) interaction site [polypeptide binding]; other site 561276002393 active site 561276002394 phosphorylation site [posttranslational modification] 561276002398 9 transmembrane helices predicted for SPN23F05210 by TMHMM2.0 at aa 108-130, 140-162, 198-220,240-262, 275-297, 307-329, 350-372, 387-409 and 422-444 561276002402 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 561276002403 beta-galactosidase; Region: BGL; TIGR03356 561276002407 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 561276002408 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 561276002409 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 561276002410 dimer interface [polypeptide binding]; other site 561276002411 motif 1; other site 561276002412 active site 561276002413 motif 2; other site 561276002414 motif 3; other site 561276002418 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 561276002419 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 561276002420 Coenzyme A binding pocket [chemical binding]; other site 561276002422 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 561276002423 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 561276002424 putative tRNA-binding site [nucleotide binding]; other site 561276002425 B3/4 domain; Region: B3_4; pfam03483 561276002426 tRNA synthetase B5 domain; Region: B5; smart00874 561276002427 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 561276002428 dimer interface [polypeptide binding]; other site 561276002429 motif 1; other site 561276002430 motif 3; other site 561276002431 motif 2; other site 561276002432 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 561276002439 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 561276002440 putative catalytic site [active] 561276002441 putative metal binding site [ion binding]; other site 561276002442 putative phosphate binding site [ion binding]; other site 561276002443 IS1239 transposase pseudogene 561276002444 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 561276002445 non-specific DNA binding site [nucleotide binding]; other site 561276002446 salt bridge; other site 561276002447 sequence-specific DNA binding site [nucleotide binding]; other site 561276002449 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 561276002450 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 561276002451 THF binding site; other site 561276002452 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 561276002453 substrate binding site [chemical binding]; other site 561276002454 THF binding site; other site 561276002455 zinc-binding site [ion binding]; other site 561276002458 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 561276002459 FAD binding site [chemical binding]; other site 561276002461 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 561276002462 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 561276002463 RNase E interface [polypeptide binding]; other site 561276002464 trimer interface [polypeptide binding]; other site 561276002465 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 561276002466 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 561276002467 RNase E interface [polypeptide binding]; other site 561276002468 trimer interface [polypeptide binding]; other site 561276002469 active site 561276002470 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 561276002471 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 561276002472 RNA binding site [nucleotide binding]; other site 561276002473 domain interface; other site 561276002481 serine O-acetyltransferase; Region: cysE; TIGR01172 561276002482 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 561276002483 trimer interface [polypeptide binding]; other site 561276002484 active site 561276002485 substrate binding site [chemical binding]; other site 561276002489 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 561276002490 Coenzyme A binding pocket [chemical binding]; other site 561276002491 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 561276002492 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 561276002493 Coenzyme A binding pocket [chemical binding]; other site 561276002496 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 561276002497 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 561276002498 active site 561276002499 HIGH motif; other site 561276002500 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 561276002501 KMSKS motif; other site 561276002502 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 561276002503 tRNA binding surface [nucleotide binding]; other site 561276002504 anticodon binding site; other site 561276002507 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 561276002508 active site 561276002509 metal binding site [ion binding]; metal-binding site 561276002510 dimerization interface [polypeptide binding]; other site 561276002512 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 561276002513 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 561276002514 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 561276002515 Transposase; Region: DDE_Tnp_ISL3; pfam01610 561276002517 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 561276002520 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 561276002521 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 561276002522 FtsX-like permease family; Region: FtsX; pfam02687 561276002523 4 transmembrane helices predicted for SPN23F05400 by TMHMM2.0 at aa 20-39, 288-310, 330-352 and 391-413 561276002525 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 561276002526 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 561276002527 Walker A/P-loop; other site 561276002528 ATP binding site [chemical binding]; other site 561276002529 Q-loop/lid; other site 561276002530 ABC transporter signature motif; other site 561276002531 Walker B; other site 561276002532 D-loop; other site 561276002533 H-loop/switch region; other site 561276002537 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 561276002538 FtsX-like permease family; Region: FtsX; pfam02687 561276002539 4 transmembrane helices predicted for SPN23F05420 by TMHMM2.0 at aa 13-35, 302-324, 344-366 and 425-447 561276002541 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 561276002542 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 561276002543 active site 561276002544 phosphorylation site [posttranslational modification] 561276002545 intermolecular recognition site; other site 561276002546 dimerization interface [polypeptide binding]; other site 561276002547 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 561276002548 DNA binding site [nucleotide binding] 561276002551 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 561276002552 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 561276002553 dimerization interface [polypeptide binding]; other site 561276002554 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 561276002555 dimer interface [polypeptide binding]; other site 561276002556 phosphorylation site [posttranslational modification] 561276002557 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 561276002558 ATP binding site [chemical binding]; other site 561276002559 Mg2+ binding site [ion binding]; other site 561276002560 G-X-G motif; other site 561276002561 2 transmembrane helices predicted for SPN23F05440 by TMHMM2.0 at aa 10-32 and 139-161 561276002565 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 561276002566 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 561276002567 intersubunit interface [polypeptide binding]; other site 561276002568 active site 561276002569 zinc binding site [ion binding]; other site 561276002570 Na+ binding site [ion binding]; other site 561276002574 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 561276002575 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 561276002576 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 561276002577 FAD binding pocket [chemical binding]; other site 561276002578 FAD binding motif [chemical binding]; other site 561276002579 phosphate binding motif [ion binding]; other site 561276002580 beta-alpha-beta structure motif; other site 561276002581 NAD binding pocket [chemical binding]; other site 561276002585 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 561276002586 dimer interface [polypeptide binding]; other site 561276002587 conserved gate region; other site 561276002588 putative PBP binding loops; other site 561276002589 ABC-ATPase subunit interface; other site 561276002591 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 561276002592 dimer interface [polypeptide binding]; other site 561276002593 conserved gate region; other site 561276002594 putative PBP binding loops; other site 561276002595 ABC-ATPase subunit interface; other site 561276002598 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 561276002599 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 561276002600 substrate binding pocket [chemical binding]; other site 561276002601 membrane-bound complex binding site; other site 561276002602 hinge residues; other site 561276002605 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 561276002606 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 561276002607 Walker A/P-loop; other site 561276002608 ATP binding site [chemical binding]; other site 561276002609 Q-loop/lid; other site 561276002610 ABC transporter signature motif; other site 561276002611 Walker B; other site 561276002612 D-loop; other site 561276002613 H-loop/switch region; other site 561276002617 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 561276002618 DHH family; Region: DHH; pfam01368 561276002619 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 561276002622 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 561276002623 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 561276002624 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 561276002627 Predicted esterase [General function prediction only]; Region: COG0627 561276002628 S-formylglutathione hydrolase; Region: PLN02442 561276002630 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 561276002631 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 561276002634 FemAB family; Region: FemAB; pfam02388 561276002636 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 561276002637 active site 561276002638 1 transmembrane helix predicted for SPN23F05560 by TMHMM2.0 at aa 20-42 561276002641 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 561276002642 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 561276002643 GIY-YIG motif/motif A; other site 561276002644 active site 561276002645 catalytic site [active] 561276002646 putative DNA binding site [nucleotide binding]; other site 561276002647 metal binding site [ion binding]; metal-binding site 561276002648 UvrB/uvrC motif; Region: UVR; pfam02151 561276002649 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 561276002653 potential frameshift: common BLAST hit: gi|116516068|ref|YP_816040.1| Ser/Thr protein phosphatase family protein 561276002654 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 561276002655 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 561276002656 active site 561276002657 metal binding site [ion binding]; metal-binding site 561276002658 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 561276002659 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 561276002660 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 561276002661 substrate binding pocket [chemical binding]; other site 561276002662 membrane-bound complex binding site; other site 561276002663 hinge residues; other site 561276002666 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 561276002667 dimer interface [polypeptide binding]; other site 561276002668 FMN binding site [chemical binding]; other site 561276002670 dipeptidase PepV; Reviewed; Region: PRK07318 561276002671 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 561276002672 active site 561276002673 metal binding site [ion binding]; metal-binding site 561276002676 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 561276002677 putative uracil binding site [chemical binding]; other site 561276002678 putative active site [active] 561276002680 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 561276002681 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 561276002682 active site residue [active] 561276002683 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 561276002685 12 transmembrane helices predicted for SPN23F05650 by TMHMM2.0 at aa 7-29, 39-61, 73-95, 117-136,148-170, 185-207, 227-249, 280-302, 315-332, 347-369,376-398 and 413-430 561276002686 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 561276002687 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 561276002688 putative oligomer interface [polypeptide binding]; other site 561276002689 putative active site [active] 561276002690 metal binding site [ion binding]; metal-binding site 561276002692 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 561276002693 nucleotide binding site/active site [active] 561276002694 HIT family signature motif; other site 561276002695 catalytic residue [active] 561276002697 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 561276002698 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 561276002701 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 561276002702 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 561276002703 23S rRNA interface [nucleotide binding]; other site 561276002704 L7/L12 interface [polypeptide binding]; other site 561276002705 putative thiostrepton binding site; other site 561276002706 L25 interface [polypeptide binding]; other site 561276002710 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 561276002711 mRNA/rRNA interface [nucleotide binding]; other site 561276002714 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 561276002715 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 561276002716 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 561276002717 Walker A/P-loop; other site 561276002718 ATP binding site [chemical binding]; other site 561276002719 Q-loop/lid; other site 561276002720 ABC transporter signature motif; other site 561276002721 Walker B; other site 561276002722 D-loop; other site 561276002723 H-loop/switch region; other site 561276002727 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 561276002728 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 561276002729 7 transmembrane helices predicted for SPN23F05750 by TMHMM2.0 at aa 26-48, 58-77, 118-140,155-177, 182-204, 209-231 and 238-260 561276002731 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG3694 561276002732 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 561276002733 5 transmembrane helices predicted for SPN23F05760 by TMHMM2.0 at aa 26-48, 128-150, 163-185,200-222 and 227-249 561276002736 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 561276002737 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 561276002738 putative active site [active] 561276002739 catalytic triad [active] 561276002740 PA_2: Protease-associated (PA) domain subgroup 2. A subgroup of PA-domain containing proteins. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is...; Region: PA_2; cd04819 561276002741 PA/protease or protease-like domain interface [polypeptide binding]; other site 561276002742 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 561276002743 catalytic residues [active] 561276002744 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 561276002745 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 561276002755 1 transmembrane helix predicted for SPN23F05790 by TMHMM2.0 at aa 2116-2138 561276002756 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 561276002757 active site 561276002758 phosphorylation site [posttranslational modification] 561276002760 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 561276002761 active site 561276002762 P-loop; other site 561276002763 phosphorylation site [posttranslational modification] 561276002765 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 561276002766 PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611 561276002767 9 transmembrane helices predicted for SPN23F05820 by TMHMM2.0 at aa 15-37, 49-71, 95-117,151-173, 242-264, 277-299, 362-381, 388-410 and 457-475 561276002769 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 561276002770 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 561276002771 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 561276002772 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 561276002773 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 561276002774 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 561276002775 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 561276002776 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 561276002777 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 561276002778 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 561276002779 G5 domain; Region: G5; pfam07501 561276002781 2 transmembrane helices predicted for SPN23F05830 by TMHMM2.0 at aa 17-39 and 2205-2227 561276002792 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 561276002793 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 561276002794 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 561276002795 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 561276002796 radical SAM superfamily pseudogene 561276002797 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 561276002799 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 561276002800 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 561276002801 10 transmembrane helices predicted for SPN23F05910 by TMHMM2.0 at aa 3-20, 24-46, 83-105, 110-132,179-201, 229-251, 272-291, 311-333, 353-372 and 382-404 561276002803 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 561276002805 5 transmembrane helices predicted for SPN23F05920 by TMHMM2.0 at aa 35-57, 142-164, 177-199,214-236 and 249-271 561276002806 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 561276002807 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 561276002808 6 transmembrane helices predicted for SPN23F05930 by TMHMM2.0 at aa 4-35, 55-77, 87-109, 134-156,171-193 and 213-235 561276002810 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 561276002811 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 561276002812 catalytic residues [active] 561276002814 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 561276002815 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 561276002816 SelR domain; Region: SelR; pfam01641 561276002817 1 transmembrane helix predicted for SPN23F05950 by TMHMM2.0 at aa 7-26 561276002820 Response regulator receiver domain; Region: Response_reg; pfam00072 561276002821 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 561276002822 active site 561276002823 phosphorylation site [posttranslational modification] 561276002824 intermolecular recognition site; other site 561276002825 dimerization interface [polypeptide binding]; other site 561276002826 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 561276002827 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 561276002832 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 561276002833 Cache domain; Region: Cache_1; pfam02743 561276002834 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 561276002835 dimerization interface [polypeptide binding]; other site 561276002836 Histidine kinase; Region: His_kinase; pfam06580 561276002837 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 561276002838 ATP binding site [chemical binding]; other site 561276002839 Mg2+ binding site [ion binding]; other site 561276002840 G-X-G motif; other site 561276002841 2 transmembrane helices predicted for SPN23F05970 by TMHMM2.0 at aa 7-29 and 277-299 561276002846 hypothetical protein; Provisional; Region: PRK13690 561276002848 M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342 561276002849 M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580 561276002857 aminodeoxychorismate synthase; Provisional; Region: PRK07508 561276002858 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 561276002859 substrate-cofactor binding pocket; other site 561276002860 homodimer interface [polypeptide binding]; other site 561276002861 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 561276002862 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 561276002863 pyridoxal 5'-phosphate binding site [chemical binding]; other site 561276002864 catalytic residue [active] 561276002866 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 561276002867 1 transmembrane helix predicted for SPN23F06010 by TMHMM2.0 at aa 5-22 561276002868 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 561276002870 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 561276002871 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 561276002872 nucleotide binding site [chemical binding]; other site 561276002875 thymidylate synthase; Reviewed; Region: thyA; PRK01827 561276002876 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 561276002877 dimerization interface [polypeptide binding]; other site 561276002878 active site 561276002880 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 561276002881 1 transmembrane helix predicted for SPN23F06060 by TMHMM2.0 at aa 5-27 561276002882 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 561276002883 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 561276002886 GTPases [General function prediction only]; Region: HflX; COG2262 561276002887 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 561276002888 HflX GTPase family; Region: HflX; cd01878 561276002889 G1 box; other site 561276002890 GTP/Mg2+ binding site [chemical binding]; other site 561276002891 Switch I region; other site 561276002892 G2 box; other site 561276002893 G3 box; other site 561276002894 Switch II region; other site 561276002895 G4 box; other site 561276002896 G5 box; other site 561276002899 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 561276002900 ribonuclease Z; Region: RNase_Z; TIGR02651 561276002902 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 561276002903 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 561276002904 NAD(P) binding site [chemical binding]; other site 561276002905 active site 561276002909 Transcriptional regulator [Transcription]; Region: LysR; COG0583 561276002910 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 561276002911 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 561276002912 dimerization interface [polypeptide binding]; other site 561276002916 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 561276002918 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 561276002919 active site residue [active] 561276002920 1 transmembrane helix predicted for SPN23F06140 by TMHMM2.0 at aa 4-22 561276002922 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 561276002923 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 561276002924 RNA binding surface [nucleotide binding]; other site 561276002925 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 561276002926 active site 561276002927 uracil binding [chemical binding]; other site 561276002931 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 561276002932 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 561276002933 G1 box; other site 561276002934 putative GEF interaction site [polypeptide binding]; other site 561276002935 GTP/Mg2+ binding site [chemical binding]; other site 561276002936 Switch I region; other site 561276002937 G2 box; other site 561276002938 G3 box; other site 561276002939 Switch II region; other site 561276002940 G4 box; other site 561276002941 G5 box; other site 561276002942 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 561276002943 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 561276002949 Protein of unknown function (DUF3165); Region: DUF3165; pfam11364 561276002950 3 transmembrane helices predicted for SPN23F06170 by TMHMM2.0 at aa 4-18, 25-47 and 51-70 561276002951 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891 561276002953 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 561276002954 2 transmembrane helices predicted for SPN23F06190 by TMHMM2.0 at aa 5-23 and 152-174 561276002955 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 561276002956 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 561276002957 3 transmembrane helices predicted for SPN23F06200 by TMHMM2.0 at aa 287-309, 329-351 and 355-374 561276002959 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 561276002960 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 561276002961 Walker A/P-loop; other site 561276002962 ATP binding site [chemical binding]; other site 561276002963 Q-loop/lid; other site 561276002964 ABC transporter signature motif; other site 561276002965 Walker B; other site 561276002966 D-loop; other site 561276002967 H-loop/switch region; other site 561276002971 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 561276002972 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 561276002973 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 561276002974 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 561276002977 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 561276002978 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 561276002979 homodimer interface [polypeptide binding]; other site 561276002980 active site 561276002983 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 561276002984 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 561276002985 Cell division protein FtsQ; Region: FtsQ; pfam03799 561276002986 1 transmembrane helix predicted for SPN23F06240 by TMHMM2.0 at aa 130-152 561276002989 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 561276002990 active site 561276002991 dimer interface [polypeptide binding]; other site 561276002994 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 561276002995 active site 561276002999 6 transmembrane helices predicted for SPN23F06280 by TMHMM2.0 at aa 17-39, 54-76, 97-119,157-179, 184-206 and 226-248 561276003000 6 transmembrane helices predicted for SPN23F06290 by TMHMM2.0 at aa 12-34, 58-80, 101-123,156-178, 185-202 and 222-244 561276003001 6 transmembrane helices predicted for SPN23F06300 by TMHMM2.0 at aa 21-40, 60-82, 108-130,140-162, 169-188 and 208-225 561276003002 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 561276003003 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 561276003004 Walker A/P-loop; other site 561276003005 ATP binding site [chemical binding]; other site 561276003006 Q-loop/lid; other site 561276003007 ABC transporter signature motif; other site 561276003008 Walker B; other site 561276003009 D-loop; other site 561276003010 H-loop/switch region; other site 561276003014 periplasmic solute-binding transport protein (pseudogene) 561276003018 1 transmembrane helix predicted for SPN23F06330 by TMHMM2.0 at aa 10-32 561276003020 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 561276003021 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 561276003022 Walker A/P-loop; other site 561276003023 ATP binding site [chemical binding]; other site 561276003024 Q-loop/lid; other site 561276003025 ABC transporter signature motif; other site 561276003026 Walker B; other site 561276003027 D-loop; other site 561276003028 H-loop/switch region; other site 561276003032 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 561276003033 dimer interface [polypeptide binding]; other site 561276003034 conserved gate region; other site 561276003035 putative PBP binding loops; other site 561276003036 ABC-ATPase subunit interface; other site 561276003039 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 561276003040 dimer interface [polypeptide binding]; other site 561276003041 conserved gate region; other site 561276003042 putative PBP binding loops; other site 561276003043 ABC-ATPase subunit interface; other site 561276003045 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 561276003047 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 561276003048 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 561276003049 dimer interface [polypeptide binding]; other site 561276003050 putative anticodon binding site; other site 561276003051 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 561276003052 motif 1; other site 561276003053 active site 561276003054 motif 2; other site 561276003055 motif 3; other site 561276003060 L-lactate oxidase; Region: L_lactate_ox; TIGR02708 561276003061 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 561276003062 teramer interface [polypeptide binding]; other site 561276003063 active site 561276003064 FMN binding site [chemical binding]; other site 561276003065 catalytic residues [active] 561276003067 Putative transcription activator [Transcription]; Region: TenA; COG0819 561276003069 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 561276003070 substrate binding site [chemical binding]; other site 561276003071 multimerization interface [polypeptide binding]; other site 561276003072 ATP binding site [chemical binding]; other site 561276003074 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 561276003075 thiamine phosphate binding site [chemical binding]; other site 561276003076 active site 561276003077 pyrophosphate binding site [ion binding]; other site 561276003079 ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721 561276003080 5 transmembrane helices predicted for SPN23F06440 by TMHMM2.0 at aa 10-32, 45-67, 77-99, 119-136 and 151-173 561276003081 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 561276003082 Walker A/P-loop; other site 561276003083 ATP binding site [chemical binding]; other site 561276003084 ABC transporter; Region: ABC_tran; pfam00005 561276003085 Q-loop/lid; other site 561276003086 ABC transporter signature motif; other site 561276003087 Walker B; other site 561276003088 D-loop; other site 561276003089 H-loop/switch region; other site 561276003090 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 561276003091 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 561276003092 Walker A/P-loop; other site 561276003093 ATP binding site [chemical binding]; other site 561276003094 Q-loop/lid; other site 561276003095 ABC transporter signature motif; other site 561276003096 Walker B; other site 561276003097 D-loop; other site 561276003098 H-loop/switch region; other site 561276003104 4 transmembrane helices predicted for SPN23F06460 by TMHMM2.0 at aa 22-44, 51-70, 85-107 and 201-215 561276003105 Putative transcription activator [Transcription]; Region: TenA; COG0819 561276003107 Predicted membrane protein [Function unknown]; Region: COG4732 561276003108 4 transmembrane helices predicted for SPN23F06480 by TMHMM2.0 at aa 37-59, 69-88, 95-117 and 137-156 561276003109 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 561276003110 substrate binding site [chemical binding]; other site 561276003111 multimerization interface [polypeptide binding]; other site 561276003112 ATP binding site [chemical binding]; other site 561276003115 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 561276003116 thiamine phosphate binding site [chemical binding]; other site 561276003117 active site 561276003118 pyrophosphate binding site [ion binding]; other site 561276003120 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 561276003121 dimer interface [polypeptide binding]; other site 561276003122 substrate binding site [chemical binding]; other site 561276003123 ATP binding site [chemical binding]; other site 561276003126 Predicted transcriptional regulator [Transcription]; Region: COG3682 561276003127 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 561276003129 Plastocyanin domain containing protein [General function prediction only]; Region: COG4633 561276003130 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 561276003131 1 transmembrane helix predicted for SPN23F06530 by TMHMM2.0 at aa 5-22 561276003132 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 561276003133 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 561276003134 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 561276003135 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 561276003136 8 transmembrane helices predicted for SPN23F06540 by TMHMM2.0 at aa 111-133, 137-154, 175-194,198-215, 349-371, 391-413, 689-711 and 721-743 561276003141 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 561276003142 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 561276003143 PYR/PP interface [polypeptide binding]; other site 561276003144 dimer interface [polypeptide binding]; other site 561276003145 tetramer interface [polypeptide binding]; other site 561276003146 TPP binding site [chemical binding]; other site 561276003147 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 561276003148 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 561276003149 TPP-binding site [chemical binding]; other site 561276003154 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 561276003155 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 561276003156 active site 561276003159 transposase (pseudogene) 561276003160 transposase (pseudogene) 561276003161 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 561276003163 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 561276003164 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 561276003167 sodium:neurotransmitter symporter family protein (pseudogene) 561276003169 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 561276003170 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 561276003171 dimer interface [polypeptide binding]; other site 561276003172 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 561276003175 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 561276003176 putative active site [active] 561276003177 nucleotide binding site [chemical binding]; other site 561276003178 nudix motif; other site 561276003179 putative metal binding site [ion binding]; other site 561276003183 HI0933-like protein; Region: HI0933_like; pfam03486 561276003184 Chromate resistance exported protein; Region: Chrome_Resist; cl01744 561276003186 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 561276003187 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 561276003189 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 561276003190 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 561276003192 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 561276003193 catalytic motif [active] 561276003194 Zn binding site [ion binding]; other site 561276003197 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 561276003198 active site 561276003200 Clp protease; Region: CLP_protease; pfam00574 561276003201 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 561276003202 oligomer interface [polypeptide binding]; other site 561276003203 active site residues [active] 561276003207 hypothetical protein; Provisional; Region: PRK02302 561276003208 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 561276003209 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 561276003210 putative ligand binding site [chemical binding]; other site 561276003213 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 561276003214 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 561276003215 TM-ABC transporter signature motif; other site 561276003217 8 transmembrane helices predicted for SPN23F06730 by TMHMM2.0 at aa 7-29, 34-51, 58-80, 90-112,133-155, 188-210, 223-245 and 260-282 561276003218 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 561276003219 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 561276003220 TM-ABC transporter signature motif; other site 561276003221 9 transmembrane helices predicted for SPN23F06740 by TMHMM2.0 at aa 7-29, 33-55, 62-80, 90-112,119-141, 156-175, 208-230, 245-267 and 279-301 561276003223 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 561276003224 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 561276003225 Walker A/P-loop; other site 561276003226 ATP binding site [chemical binding]; other site 561276003227 Q-loop/lid; other site 561276003228 ABC transporter signature motif; other site 561276003229 Walker B; other site 561276003230 D-loop; other site 561276003231 H-loop/switch region; other site 561276003236 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 561276003237 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 561276003238 Walker A/P-loop; other site 561276003239 ATP binding site [chemical binding]; other site 561276003240 Q-loop/lid; other site 561276003241 ABC transporter signature motif; other site 561276003242 Walker B; other site 561276003243 D-loop; other site 561276003244 H-loop/switch region; other site 561276003248 FOG: CBS domain [General function prediction only]; Region: COG0517 561276003249 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 561276003250 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 561276003252 PCRF domain; Region: PCRF; pfam03462 561276003253 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 561276003254 RF-1 domain; Region: RF-1; pfam00472 561276003257 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 561276003258 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 561276003259 Walker A/P-loop; other site 561276003260 ATP binding site [chemical binding]; other site 561276003261 Q-loop/lid; other site 561276003262 ABC transporter signature motif; other site 561276003263 Walker B; other site 561276003264 D-loop; other site 561276003265 H-loop/switch region; other site 561276003269 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 561276003270 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 561276003271 4 transmembrane helices predicted for SPN23F06800 by TMHMM2.0 at aa 21-43, 179-201, 236-258 and 278-300 561276003273 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 561276003274 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 561276003275 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 561276003276 active site turn [active] 561276003277 phosphorylation site [posttranslational modification] 561276003278 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 561276003279 HPr interaction site; other site 561276003280 glycerol kinase (GK) interaction site [polypeptide binding]; other site 561276003281 active site 561276003282 phosphorylation site [posttranslational modification] 561276003284 9 transmembrane helices predicted for SPN23F06810 by TMHMM2.0 at aa 21-43, 58-80, 87-109,142-164, 185-207, 313-330, 342-359, 364-386 and 419-441 561276003289 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 561276003290 putative catalytic site [active] 561276003291 putative metal binding site [ion binding]; other site 561276003292 putative phosphate binding site [ion binding]; other site 561276003294 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 561276003295 DEAD-like helicases superfamily; Region: DEXDc; smart00487 561276003296 ATP binding site [chemical binding]; other site 561276003297 Mg++ binding site [ion binding]; other site 561276003298 motif III; other site 561276003299 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 561276003300 nucleotide binding region [chemical binding]; other site 561276003301 ATP-binding site [chemical binding]; other site 561276003304 S-adenosylmethionine synthetase; Validated; Region: PRK05250 561276003305 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 561276003306 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 561276003307 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 561276003313 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 561276003314 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 561276003315 active site 561276003316 FMN binding site [chemical binding]; other site 561276003317 substrate binding site [chemical binding]; other site 561276003318 catalytic residues [active] 561276003319 homodimer interface [polypeptide binding]; other site 561276003323 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 561276003324 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 561276003326 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 561276003327 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 561276003328 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 561276003332 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 561276003334 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454 561276003335 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 561276003337 4 transmembrane helices predicted for SPN23F06910 by TMHMM2.0 at aa 7-29, 72-94, 103-121 and 136-150 561276003338 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 561276003339 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 561276003340 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 561276003341 ABC transporter; Region: ABC_tran_2; pfam12848 561276003342 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 561276003349 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 561276003350 Transposase; Region: DDE_Tnp_ISL3; pfam01610 561276003352 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 561276003353 active site 561276003356 1 transmembrane helix predicted for SPN23F06950 by TMHMM2.0 at aa 15-37 561276003357 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 561276003359 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 561276003360 KH domain; Region: KH_4; pfam13083 561276003361 G-X-X-G motif; other site 561276003363 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 561276003364 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 561276003365 RimM N-terminal domain; Region: RimM; pfam01782 561276003366 PRC-barrel domain; Region: PRC; pfam05239 561276003369 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 561276003371 ATP cone domain; Region: ATP-cone; pfam03477 561276003373 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4443 561276003374 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 561276003376 1 transmembrane helix predicted for SPN23F07060 by TMHMM2.0 at aa 12-34 561276003377 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 561276003378 8 transmembrane helices predicted for SPN23F07070 by TMHMM2.0 at aa 5-24, 136-158, 183-205,220-242, 261-280, 560-579, 599-621 and 625-644 561276003380 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 561276003381 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 561276003382 Walker A/P-loop; other site 561276003383 ATP binding site [chemical binding]; other site 561276003384 Q-loop/lid; other site 561276003385 ABC transporter signature motif; other site 561276003386 Walker B; other site 561276003387 D-loop; other site 561276003388 H-loop/switch region; other site 561276003392 1 transmembrane helix predicted for SPN23F07090 by TMHMM2.0 at aa 5-22 561276003393 glutathione reductase; Validated; Region: PRK06116 561276003394 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 561276003395 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 561276003396 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 561276003401 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 561276003402 HlyD family secretion protein; Region: HlyD_3; pfam13437 561276003403 1 transmembrane helix predicted for SPN23F07110 by TMHMM2.0 at aa 13-32 561276003404 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 561276003405 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 561276003406 Walker A/P-loop; other site 561276003407 ATP binding site [chemical binding]; other site 561276003408 Q-loop/lid; other site 561276003409 ABC transporter signature motif; other site 561276003410 Walker B; other site 561276003411 D-loop; other site 561276003412 H-loop/switch region; other site 561276003416 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 561276003417 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 561276003418 FtsX-like permease family; Region: FtsX; pfam02687 561276003419 4 transmembrane helices predicted for SPN23F07130 by TMHMM2.0 at aa 20-42, 291-313, 334-365 and 380-402 561276003421 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 561276003422 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 561276003423 active site 561276003424 HIGH motif; other site 561276003425 KMSKS motif; other site 561276003426 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 561276003427 tRNA binding surface [nucleotide binding]; other site 561276003428 anticodon binding site; other site 561276003429 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 561276003430 dimer interface [polypeptide binding]; other site 561276003431 putative tRNA-binding site [nucleotide binding]; other site 561276003434 Predicted transcriptional regulators [Transcription]; Region: COG1695 561276003435 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 561276003437 6 transmembrane helices predicted for SPN23F07170 by TMHMM2.0 at aa 92-109, 124-146, 158-180,184-206, 211-233 and 238-260 561276003438 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 561276003439 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 561276003440 active site 561276003441 catalytic tetrad [active] 561276003443 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 561276003444 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 561276003445 classical (c) SDRs; Region: SDR_c; cd05233 561276003446 NAD(P) binding site [chemical binding]; other site 561276003447 active site 561276003450 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 561276003451 nudix motif; other site 561276003454 GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746 561276003456 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574 561276003457 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 561276003459 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 561276003461 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 561276003462 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 561276003463 Zn binding site [ion binding]; other site 561276003466 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 561276003467 Transposase; Region: DDE_Tnp_ISL3; pfam01610 561276003469 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 561276003470 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 561276003471 active site 561276003472 phosphorylation site [posttranslational modification] 561276003473 intermolecular recognition site; other site 561276003474 dimerization interface [polypeptide binding]; other site 561276003475 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 561276003476 DNA binding site [nucleotide binding] 561276003479 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 561276003480 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 561276003481 dimer interface [polypeptide binding]; other site 561276003482 phosphorylation site [posttranslational modification] 561276003483 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 561276003484 ATP binding site [chemical binding]; other site 561276003485 Mg2+ binding site [ion binding]; other site 561276003486 G-X-G motif; other site 561276003487 2 transmembrane helices predicted for SPN23F07280 by TMHMM2.0 at aa 15-37 and 183-205 561276003490 Protein of unknown function (DUF3270); Region: DUF3270; pfam11674 561276003491 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 561276003492 Peptidase family U32; Region: Peptidase_U32; pfam01136 561276003494 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK07246 561276003495 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 561276003496 active site 561276003497 catalytic site [active] 561276003498 substrate binding site [chemical binding]; other site 561276003499 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 561276003500 ATP binding site [chemical binding]; other site 561276003501 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 561276003505 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 561276003507 10 transmembrane helices predicted for SPN23F07320 by TMHMM2.0 at aa 11-33, 48-70, 75-97, 110-132,145-167, 172-191, 196-215, 288-310, 323-340 and 355-377 561276003508 DJ-1 family protein; Region: not_thiJ; TIGR01383 561276003509 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 561276003510 conserved cys residue [active] 561276003512 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 561276003513 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 561276003514 motif II; other site 561276003517 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 561276003518 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 561276003519 Mg2+ binding site [ion binding]; other site 561276003520 G-X-G motif; other site 561276003521 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 561276003522 anchoring element; other site 561276003523 dimer interface [polypeptide binding]; other site 561276003524 ATP binding site [chemical binding]; other site 561276003525 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 561276003526 active site 561276003527 putative metal-binding site [ion binding]; other site 561276003528 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 561276003534 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 561276003535 1 transmembrane helix predicted for SPN23F07360 by TMHMM2.0 at aa 5-27 561276003537 transposase pseudogene 561276003539 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 561276003541 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 561276003542 nudix motif; other site 561276003545 IS640-Spn1 transposase (pseudogene) 561276003547 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 561276003548 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 561276003549 Walker A motif; other site 561276003550 ATP binding site [chemical binding]; other site 561276003551 Walker B motif; other site 561276003552 arginine finger; other site 561276003553 UvrB/uvrC motif; Region: UVR; pfam02151 561276003554 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 561276003555 Walker A motif; other site 561276003556 ATP binding site [chemical binding]; other site 561276003557 Walker B motif; other site 561276003558 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 561276003566 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703 561276003568 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 561276003569 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 561276003570 dimer interface [polypeptide binding]; other site 561276003571 conserved gate region; other site 561276003572 putative PBP binding loops; other site 561276003573 ABC-ATPase subunit interface; other site 561276003575 3 transmembrane helices predicted for SPN23F07440 by TMHMM2.0 at aa 15-37, 50-72 and 195-217 561276003577 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 561276003578 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 561276003579 Walker A/P-loop; other site 561276003580 ATP binding site [chemical binding]; other site 561276003581 Q-loop/lid; other site 561276003582 ABC transporter signature motif; other site 561276003583 Walker B; other site 561276003584 D-loop; other site 561276003585 H-loop/switch region; other site 561276003589 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179 561276003590 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 561276003591 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 561276003592 homodimer interface [polypeptide binding]; other site 561276003593 NADP binding site [chemical binding]; other site 561276003594 substrate binding site [chemical binding]; other site 561276003599 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 561276003600 putative substrate binding site [chemical binding]; other site 561276003601 putative ATP binding site [chemical binding]; other site 561276003602 1 transmembrane helix predicted for SPN23F07480 by TMHMM2.0 at aa 26-48 561276003605 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 561276003606 tetramer (dimer of dimers) interface [polypeptide binding]; other site 561276003607 active site 561276003608 dimer interface [polypeptide binding]; other site 561276003610 phosphopentomutase; Provisional; Region: PRK05362 561276003611 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 561276003614 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3797 561276003616 purine nucleoside phosphorylase; Provisional; Region: PRK08202 561276003619 cytolysin (pseudogene) 561276003621 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 561276003624 topology modulation protein; Provisional; Region: PRK07261 561276003625 AAA domain; Region: AAA_17; pfam13207 561276003627 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 561276003629 pantothenate kinase; Provisional; Region: PRK05439 561276003630 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 561276003631 ATP-binding site [chemical binding]; other site 561276003632 CoA-binding site [chemical binding]; other site 561276003633 Mg2+-binding site [ion binding]; other site 561276003636 membrane protein (pseudogene) 561276003637 2 transmembrane helices predicted for SPN23F07610 by TMHMM2.0 at aa 7-26 and 41-63 561276003638 Methyltransferase domain; Region: Methyltransf_31; pfam13847 561276003639 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 561276003640 S-adenosylmethionine binding site [chemical binding]; other site 561276003642 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 561276003643 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 561276003644 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 561276003645 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 561276003650 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 561276003651 intersubunit interface [polypeptide binding]; other site 561276003652 active site 561276003653 catalytic residue [active] 561276003655 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 561276003656 active site 561276003657 catalytic motif [active] 561276003658 Zn binding site [ion binding]; other site 561276003661 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 561276003662 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 561276003663 ligand binding site [chemical binding]; other site 561276003667 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 561276003668 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 561276003669 Walker A/P-loop; other site 561276003670 ATP binding site [chemical binding]; other site 561276003671 Q-loop/lid; other site 561276003672 ABC transporter signature motif; other site 561276003673 Walker B; other site 561276003674 D-loop; other site 561276003675 H-loop/switch region; other site 561276003676 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 561276003681 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 561276003682 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 561276003683 TM-ABC transporter signature motif; other site 561276003684 9 transmembrane helices predicted for SPN23F07680 by TMHMM2.0 at aa 12-31, 46-68, 75-97, 107-129,138-160, 193-211, 240-262, 282-304 and 316-338 561276003686 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 561276003687 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 561276003688 TM-ABC transporter signature motif; other site 561276003689 10 transmembrane helices predicted for SPN23F07690 by TMHMM2.0 at aa 7-29, 34-56, 69-88, 98-120,132-151, 156-173, 202-224, 228-247, 252-274 and 284-306 561276003691 IS861 orf A (pseudogene) 561276003692 putative transposase OrfB; Reviewed; Region: PHA02517 561276003693 HTH-like domain; Region: HTH_21; pfam13276 561276003694 Integrase core domain; Region: rve; pfam00665 561276003695 Integrase core domain; Region: rve_2; pfam13333 561276003697 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 561276003699 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 561276003700 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 561276003701 Mg2+ binding site [ion binding]; other site 561276003702 G-X-G motif; other site 561276003703 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 561276003704 anchoring element; other site 561276003705 dimer interface [polypeptide binding]; other site 561276003706 ATP binding site [chemical binding]; other site 561276003707 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 561276003708 active site 561276003709 putative metal-binding site [ion binding]; other site 561276003710 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 561276003716 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 561276003717 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 561276003718 CAP-like domain; other site 561276003719 active site 561276003720 primary dimer interface [polypeptide binding]; other site 561276003721 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 561276003729 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 561276003730 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 561276003731 homodimer interface [polypeptide binding]; other site 561276003732 substrate-cofactor binding pocket; other site 561276003733 catalytic residue [active] 561276003736 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 561276003737 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 561276003739 Predicted membrane protein [Function unknown]; Region: COG3819 561276003741 4 transmembrane helices predicted for SPN23F07790 by TMHMM2.0 at aa 7-29, 57-76, 158-177 and 192-214 561276003742 Predicted membrane protein [Function unknown]; Region: COG3817 561276003743 Protein of unknown function (DUF979); Region: DUF979; pfam06166 561276003744 8 transmembrane helices predicted for SPN23F07800 by TMHMM2.0 at aa 7-26, 46-68, 101-120,125-144, 165-187, 202-224, 231-253 and 283-305 561276003746 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 561276003747 putative substrate binding pocket [chemical binding]; other site 561276003748 AC domain interface; other site 561276003749 catalytic triad [active] 561276003750 AB domain interface; other site 561276003751 interchain disulfide; other site 561276003755 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 561276003756 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 561276003757 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 561276003758 RNA binding site [nucleotide binding]; other site 561276003759 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 561276003760 RNA binding site [nucleotide binding]; other site 561276003761 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 561276003762 RNA binding site [nucleotide binding]; other site 561276003763 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 561276003764 RNA binding site [nucleotide binding]; other site 561276003768 IS1167 transposase (pseudogene) 561276003770 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 561276003771 GAF domain; Region: GAF_2; pfam13185 561276003772 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 561276003773 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 561276003774 Walker A motif; other site 561276003775 ATP binding site [chemical binding]; other site 561276003776 Walker B motif; other site 561276003777 arginine finger; other site 561276003778 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 561276003781 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 561276003782 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 561276003783 Walker A/P-loop; other site 561276003784 ATP binding site [chemical binding]; other site 561276003785 Q-loop/lid; other site 561276003786 ABC transporter signature motif; other site 561276003787 Walker B; other site 561276003788 D-loop; other site 561276003789 H-loop/switch region; other site 561276003793 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 561276003794 FeS assembly protein SufD; Region: sufD; TIGR01981 561276003796 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 561276003797 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 561276003798 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 561276003799 catalytic residue [active] 561276003802 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 561276003803 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 561276003804 trimerization site [polypeptide binding]; other site 561276003805 active site 561276003807 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 561276003808 FeS assembly protein SufB; Region: sufB; TIGR01980 561276003810 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 561276003811 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 561276003812 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 561276003815 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 561276003816 Domain of unknown function DUF20; Region: UPF0118; pfam01594 561276003818 7 transmembrane helices predicted for SPN23F07960 by TMHMM2.0 at aa 15-37, 49-71, 135-157,193-215, 230-252, 257-279 and 289-311 561276003819 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 561276003820 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 561276003821 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 561276003825 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 561276003826 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 561276003827 putative substrate binding site [chemical binding]; other site 561276003828 putative ATP binding site [chemical binding]; other site 561276003831 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 561276003832 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 561276003833 active site 561276003834 phosphorylation site [posttranslational modification] 561276003835 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 561276003836 active site 561276003837 P-loop; other site 561276003838 phosphorylation site [posttranslational modification] 561276003839 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 561276003843 9 transmembrane helices predicted for SPN23F07990 by TMHMM2.0 at aa 303-325, 340-362, 405-427,442-463, 475-497, 525-547, 559-581, 586-608 and 615-637 561276003846 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 561276003847 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 561276003848 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 561276003849 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 561276003850 5 transmembrane helices predicted for SPN23F08010 by TMHMM2.0 at aa 2-24, 28-50, 59-81, 101-123 and 130-152 561276003853 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 561276003854 1 transmembrane helix predicted for SPN23F08020 by TMHMM2.0 at aa 21-43 561276003855 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 561276003856 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 561276003857 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 561276003858 catalytic residue [active] 561276003861 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 561276003862 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 561276003863 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 561276003864 Ligand Binding Site [chemical binding]; other site 561276003867 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 561276003868 Putative esterase; Region: Esterase; pfam00756 561276003869 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 561276003871 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 561276003873 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 561276003874 HsdM N-terminal domain; Region: HsdM_N; pfam12161 561276003875 Methyltransferase domain; Region: Methyltransf_26; pfam13659 561276003879 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 561276003880 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 561276003883 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 561276003884 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 561276003886 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 561276003887 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 561276003888 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 561276003889 active site 561276003890 catalytic residues [active] 561276003891 DNA binding site [nucleotide binding] 561276003892 Int/Topo IB signature motif; other site 561276003895 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 561276003897 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 561276003898 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 561276003899 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 561276003900 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 561276003901 ATP binding site [chemical binding]; other site 561276003902 putative Mg++ binding site [ion binding]; other site 561276003903 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 561276003907 Arginine repressor [Transcription]; Region: ArgR; COG1438 561276003908 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 561276003909 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 561276003912 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 561276003913 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; pfam09168 561276003914 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 561276003918 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279 561276003919 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 561276003920 active site 561276003921 PHP Thumb interface [polypeptide binding]; other site 561276003922 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 561276003923 generic binding surface II; other site 561276003924 generic binding surface I; other site 561276003928 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 561276003929 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 561276003930 active site 561276003931 ADP/pyrophosphate binding site [chemical binding]; other site 561276003932 dimerization interface [polypeptide binding]; other site 561276003933 allosteric effector site; other site 561276003934 fructose-1,6-bisphosphate binding site; other site 561276003937 pyruvate kinase; Provisional; Region: PRK05826 561276003938 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 561276003939 domain interfaces; other site 561276003940 active site 561276003943 repressor protein (pseudogene) 561276003944 Domain of unknown function (DUF4300); Region: DUF4300; pfam14133 561276003946 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 561276003948 Predicted membrane protein [Function unknown]; Region: COG3689 561276003950 Predicted permeases [General function prediction only]; Region: COG0701 561276003952 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 561276003953 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 561276003954 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 561276003955 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 561276003956 RNA binding site [nucleotide binding]; other site 561276003958 SprT homologues; Region: SprT; cl01182 561276003959 hypothetical protein; Provisional; Region: PRK04351 561276003961 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 561276003963 1 transmembrane helix predicted for SPN23F08310 by TMHMM2.0 at aa 31-53 561276003964 1 transmembrane helix predicted for SPN23F08320 by TMHMM2.0 at aa 20-42 561276003965 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 561276003966 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 561276003967 Walker A/P-loop; other site 561276003968 ATP binding site [chemical binding]; other site 561276003969 Q-loop/lid; other site 561276003970 ABC transporter signature motif; other site 561276003971 Walker B; other site 561276003972 D-loop; other site 561276003973 H-loop/switch region; other site 561276003977 FtsX-like permease family; Region: FtsX; pfam02687 561276003979 10 transmembrane helices predicted for SPN23F08340 by TMHMM2.0 at aa 20-42, 55-77, 110-132,155-177, 198-220, 230-252, 284-306, 537-559, 593-615 and 630-652 561276003980 disrupted by IS insertion; membrane protein (pseudogene) 561276003982 IS1239 transposase (pseudogene) 561276003984 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 561276003985 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 561276003986 homodimer interface [polypeptide binding]; other site 561276003987 pyridoxal 5'-phosphate binding site [chemical binding]; other site 561276003988 catalytic residue [active] 561276003989 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 561276003994 transposase (pseudogene) 561276003997 spermidine synthase; Provisional; Region: PRK00811 561276003998 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 561276003999 S-adenosylmethionine binding site [chemical binding]; other site 561276004003 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 561276004004 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; pfam01488 561276004007 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 561276004008 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 561276004009 dimer interface [polypeptide binding]; other site 561276004010 active site 561276004011 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 561276004012 catalytic residues [active] 561276004013 substrate binding site [chemical binding]; other site 561276004015 agmatine deiminase; Provisional; Region: PRK13551 561276004016 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 561276004018 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 561276004019 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 561276004020 putative active site; other site 561276004021 catalytic triad [active] 561276004022 putative dimer interface [polypeptide binding]; other site 561276004024 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 561276004025 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 561276004026 active site 561276004027 motif I; other site 561276004028 motif II; other site 561276004029 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 561276004033 CAAX protease self-immunity; Region: Abi; pfam02517 561276004034 7 transmembrane helices predicted for SPN23F08480 by TMHMM2.0 at aa 7-26, 41-63, 76-98, 120-142,149-168, 172-191 and 198-220 561276004036 Transcriptional regulator [Transcription]; Region: LysR; COG0583 561276004037 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 561276004038 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 561276004039 dimerization interface [polypeptide binding]; other site 561276004043 lipoprotein signal peptidase; Provisional; Region: PRK14797 561276004045 4 transmembrane helices predicted for SPN23F08510 by TMHMM2.0 at aa 5-27, 61-80, 87-109 and 124-146 561276004046 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 561276004047 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 561276004048 RNA binding surface [nucleotide binding]; other site 561276004049 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 561276004050 active site 561276004054 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 561276004055 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 561276004056 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 561276004064 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 561276004065 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 561276004066 nucleotide binding site [chemical binding]; other site 561276004067 homotetrameric interface [polypeptide binding]; other site 561276004068 putative phosphate binding site [ion binding]; other site 561276004069 putative allosteric binding site; other site 561276004070 PUA domain; Region: PUA; pfam01472 561276004075 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 561276004076 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 561276004077 putative catalytic cysteine [active] 561276004079 pyrroline-5-carboxylate reductase; Region: PLN02688 561276004080 Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345 561276004084 thymidylate kinase; Validated; Region: tmk; PRK00698 561276004085 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 561276004086 TMP-binding site; other site 561276004087 ATP-binding site [chemical binding]; other site 561276004091 DNA polymerase III subunit delta'; Validated; Region: PRK07276 561276004092 DNA polymerase III subunit delta'; Validated; Region: PRK08485 561276004093 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 561276004095 Predicted methyltransferases [General function prediction only]; Region: COG0313 561276004096 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 561276004097 putative SAM binding site [chemical binding]; other site 561276004098 putative homodimer interface [polypeptide binding]; other site 561276004101 Uncharacterized conserved protein [Function unknown]; Region: COG4283 561276004103 replication initiation protein (pseudogene) 561276004105 IS1381 transposase (pseudogene) 561276004107 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 561276004108 Glucose inhibited division protein A; Region: GIDA; pfam01134 561276004111 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 561276004112 putative nucleotide binding site [chemical binding]; other site 561276004113 uridine monophosphate binding site [chemical binding]; other site 561276004114 homohexameric interface [polypeptide binding]; other site 561276004116 ribosome recycling factor; Reviewed; Region: frr; PRK00083 561276004117 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 561276004118 hinge region; other site 561276004120 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 561276004121 S1 domain; Region: S1_2; pfam13509 561276004122 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 561276004123 hypothetical protein; Provisional; Region: PRK13672 561276004125 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 561276004126 PhoH-like protein; Region: PhoH; pfam02562 561276004129 acetyltransferase (pseudogene) 561276004131 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 561276004133 alanine dehydrogenase 1 (pseudogene) 561276004137 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 561276004138 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 561276004140 SLBB domain; Region: SLBB; pfam10531 561276004141 comEA protein; Region: comE; TIGR01259 561276004142 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 561276004143 1 transmembrane helix predicted for SPN23F08790 by TMHMM2.0 at aa 13-30 561276004146 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 561276004147 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 561276004148 Competence protein; Region: Competence; pfam03772 561276004149 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 561276004150 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 561276004151 9 transmembrane helices predicted for SPN23F08800 by TMHMM2.0 at aa 20-42, 52-69, 231-253,273-295, 316-338, 353-375, 382-404, 436-455 and 462-479 561276004154 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 561276004155 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 561276004156 Walker A/P-loop; other site 561276004157 ATP binding site [chemical binding]; other site 561276004158 Q-loop/lid; other site 561276004159 ABC transporter signature motif; other site 561276004160 Walker B; other site 561276004161 D-loop; other site 561276004162 H-loop/switch region; other site 561276004166 7 transmembrane helices predicted for SPN23F08830 by TMHMM2.0 at aa 15-37, 172-194, 204-226,228-250, 276-298, 305-322 and 357-379 561276004167 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 561276004168 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 561276004169 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 561276004173 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 561276004175 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 561276004176 23S rRNA binding site [nucleotide binding]; other site 561276004177 L21 binding site [polypeptide binding]; other site 561276004178 L13 binding site [polypeptide binding]; other site 561276004181 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 561276004182 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 561276004183 dimer interface [polypeptide binding]; other site 561276004184 active site 561276004185 metal binding site [ion binding]; metal-binding site 561276004186 glutathione binding site [chemical binding]; other site 561276004189 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 561276004190 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 561276004191 FAD binding pocket [chemical binding]; other site 561276004192 FAD binding motif [chemical binding]; other site 561276004193 phosphate binding motif [ion binding]; other site 561276004194 beta-alpha-beta structure motif; other site 561276004195 NAD binding pocket [chemical binding]; other site 561276004196 Iron coordination center [ion binding]; other site 561276004199 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 561276004200 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 561276004201 heterodimer interface [polypeptide binding]; other site 561276004202 active site 561276004203 FMN binding site [chemical binding]; other site 561276004204 homodimer interface [polypeptide binding]; other site 561276004205 substrate binding site [chemical binding]; other site 561276004209 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 561276004210 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 561276004211 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 561276004223 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 561276004224 Domain of unknown function (DUF814); Region: DUF814; pfam05670 561276004227 metal-binding heat shock protein; Provisional; Region: PRK00016 561276004229 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 561276004231 3 transmembrane helices predicted for SPN23F08930 by TMHMM2.0 at aa 39-58, 62-84 and 105-127 561276004233 GTPase Era; Reviewed; Region: era; PRK00089 561276004234 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 561276004235 G1 box; other site 561276004236 GTP/Mg2+ binding site [chemical binding]; other site 561276004237 Switch I region; other site 561276004238 G2 box; other site 561276004239 Switch II region; other site 561276004240 G3 box; other site 561276004241 G4 box; other site 561276004242 G5 box; other site 561276004243 KH domain; Region: KH_2; pfam07650 561276004247 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 561276004248 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 561276004249 DNA binding site [nucleotide binding] 561276004250 catalytic residue [active] 561276004251 H2TH interface [polypeptide binding]; other site 561276004252 putative catalytic residues [active] 561276004253 turnover-facilitating residue; other site 561276004254 intercalation triad [nucleotide binding]; other site 561276004255 8OG recognition residue [nucleotide binding]; other site 561276004256 putative reading head residues; other site 561276004257 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 561276004258 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 561276004263 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 561276004264 dephospho-CoA kinase; Region: TIGR00152 561276004265 CoA-binding site [chemical binding]; other site 561276004266 ATP-binding [chemical binding]; other site 561276004269 drug efflux system protein MdtG; Provisional; Region: PRK09874 561276004270 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 561276004271 putative substrate translocation pore; other site 561276004272 10 transmembrane helices predicted for SPN23F08970 by TMHMM2.0 at aa 12-34, 49-71, 84-106,140-162, 167-186, 217-239, 248-270, 306-328, 340-362 and 366-388 561276004275 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 561276004277 2 transmembrane helices predicted for SPN23F08980 by TMHMM2.0 at aa 2-24 and 52-74 561276004278 ribonuclease R; Region: RNase_R; TIGR02063 561276004279 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 561276004280 RNB domain; Region: RNB; pfam00773 561276004281 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 561276004282 RNA binding site [nucleotide binding]; other site 561276004287 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 561276004288 SmpB-tmRNA interface; other site 561276004291 tellurite resistance protein TehB; Provisional; Region: PRK12335 561276004292 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 561276004293 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 561276004294 S-adenosylmethionine binding site [chemical binding]; other site 561276004297 Competence protein CoiA-like family, contains a predicted nuclease domain [General function prediction only]; Region: CoiA; COG4469 561276004299 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 561276004300 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 561276004301 active site 561276004302 Zn binding site [ion binding]; other site 561276004305 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 561276004306 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 561276004307 S-adenosylmethionine binding site [chemical binding]; other site 561276004309 foldase protein PrsA; Reviewed; Region: prsA; PRK01326 561276004310 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 561276004313 IS3-Spn1 orf B fragment (pseudogene) 561276004315 IS3-Spn1 orf A fragment (pseudogene) 561276004317 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 561276004318 catalytic core [active] 561276004320 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 561276004321 putative deacylase active site [active] 561276004323 Predicted membrane protein [Function unknown]; Region: COG2035 561276004325 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 561276004326 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 561276004327 active site 561276004329 1 transmembrane helix predicted for SPN23F09120 by TMHMM2.0 at aa 7-24 561276004330 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 561276004331 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 561276004332 Substrate binding site; other site 561276004333 Mg++ binding site; other site 561276004334 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 561276004335 active site 561276004336 substrate binding site [chemical binding]; other site 561276004337 CoA binding site [chemical binding]; other site 561276004347 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 561276004348 dimer interface [polypeptide binding]; other site 561276004349 ADP-ribose binding site [chemical binding]; other site 561276004350 active site 561276004351 nudix motif; other site 561276004352 metal binding site [ion binding]; metal-binding site 561276004354 1 transmembrane helix predicted for SPN23F09150 by TMHMM2.0 at aa 78-100 561276004355 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 561276004356 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 561276004358 MarR family; Region: MarR_2; cl17246 561276004360 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 561276004361 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 561276004362 active site 561276004363 catalytic site [active] 561276004364 substrate binding site [chemical binding]; other site 561276004366 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781 561276004367 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 561276004368 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 561276004369 putative active site [active] 561276004370 catalytic site [active] 561276004371 putative metal binding site [ion binding]; other site 561276004372 7 transmembrane helices predicted for SPN23F09190 by TMHMM2.0 at aa 21-43, 75-97, 126-145,172-194, 226-248, 263-285 and 306-328 561276004374 IS630-Spn1 transposase (pseudogene) 561276004376 uncharacterized protein (pseudogene) 561276004377 1 transmembrane helix predicted for SPN23F09230 by TMHMM2.0 at aa 41-63 561276004378 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 561276004379 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 561276004380 6 transmembrane helices predicted for SPN23F09250 by TMHMM2.0 at aa 4-35, 56-78, 88-110, 130-152,167-189 and 210-232 561276004383 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 561276004384 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 561276004385 catalytic residues [active] 561276004388 amino acid transporter; Region: 2A0306; TIGR00909 561276004389 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 561276004391 11 transmembrane helices predicted for SPN23F09270 by TMHMM2.0 at aa 25-47, 51-73, 85-107,148-170, 177-199, 214-236, 257-279, 299-321, 374-396,411-430 and 437-456 561276004392 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 561276004393 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 561276004394 metal binding site [ion binding]; metal-binding site 561276004397 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 561276004398 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 561276004399 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 561276004400 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 561276004406 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 561276004407 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 561276004408 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 561276004409 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 561276004410 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 561276004416 pneumococcal histidine triad protein E alternate (pseudogene) 561276004417 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 561276004418 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 561276004419 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 561276004423 uncharacterized protein (pseudogene) 561276004424 peptidase T; Region: peptidase-T; TIGR01882 561276004425 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 561276004426 metal binding site [ion binding]; metal-binding site 561276004427 dimer interface [polypeptide binding]; other site 561276004432 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 561276004433 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 561276004434 C-terminal domain interface [polypeptide binding]; other site 561276004435 active site 561276004436 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 561276004437 active site 561276004438 N-terminal domain interface [polypeptide binding]; other site 561276004441 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 561276004442 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 561276004444 Predicted membrane protein [Function unknown]; Region: COG2246 561276004445 GtrA-like protein; Region: GtrA; pfam04138 561276004447 Predicted membrane protein [Function unknown]; Region: COG4708 561276004449 5 transmembrane helices predicted for SPN23F09370 by TMHMM2.0 at aa 13-35, 48-70, 75-97, 110-132 and 137-159 561276004450 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 561276004451 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 561276004454 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 561276004455 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 561276004456 dimer interface [polypeptide binding]; other site 561276004457 active site 561276004458 catalytic residue [active] 561276004460 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 561276004461 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 561276004462 trmE is a tRNA modification GTPase; Region: trmE; cd04164 561276004463 G1 box; other site 561276004464 GTP/Mg2+ binding site [chemical binding]; other site 561276004465 Switch I region; other site 561276004466 G2 box; other site 561276004467 Switch II region; other site 561276004468 G3 box; other site 561276004469 G4 box; other site 561276004470 G5 box; other site 561276004471 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 561276004474 4-oxalocrotonate tautomerase; Provisional; Region: PRK02289 561276004475 active site 1 [active] 561276004476 dimer interface [polypeptide binding]; other site 561276004477 hexamer interface [polypeptide binding]; other site 561276004478 active site 2 [active] 561276004480 thymidine kinase; Provisional; Region: PRK04296 561276004484 peptide chain release factor 1; Validated; Region: prfA; PRK00591 561276004485 This domain is found in peptide chain release factors; Region: PCRF; smart00937 561276004486 RF-1 domain; Region: RF-1; pfam00472 561276004489 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 561276004490 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 561276004491 S-adenosylmethionine binding site [chemical binding]; other site 561276004494 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 561276004496 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 561276004497 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 561276004498 Coenzyme A binding pocket [chemical binding]; other site 561276004500 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 561276004501 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 561276004502 dimer interface [polypeptide binding]; other site 561276004503 active site 561276004504 glycine-pyridoxal phosphate binding site [chemical binding]; other site 561276004505 folate binding site [chemical binding]; other site 561276004508 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 561276004509 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 561276004510 Lysozyme-like; Region: Lysozyme_like; pfam13702 561276004511 catalytic residue [active] 561276004512 Predicted secreted protein [Function unknown]; Region: COG4086 561276004513 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 561276004515 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 561276004516 TRAM domain; Region: TRAM; cl01282 561276004517 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 561276004518 S-adenosylmethionine binding site [chemical binding]; other site 561276004522 low 4.94066E-324C 561276004523 Predicted transcriptional regulator [Transcription]; Region: COG3655 561276004524 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 561276004525 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 561276004526 siderophore binding site; other site 561276004529 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 561276004530 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 561276004531 ABC-ATPase subunit interface; other site 561276004532 dimer interface [polypeptide binding]; other site 561276004533 putative PBP binding regions; other site 561276004534 8 transmembrane helices predicted for SPN23F09540 by TMHMM2.0 at aa 7-29, 61-80, 93-115, 120-142,149-171, 191-213, 243-265 and 309-326 561276004536 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 561276004537 ABC-ATPase subunit interface; other site 561276004538 dimer interface [polypeptide binding]; other site 561276004539 putative PBP binding regions; other site 561276004540 9 transmembrane helices predicted for SPN23F09550 by TMHMM2.0 at aa 15-37, 70-92, 96-118,125-144, 154-176, 200-217, 243-277, 284-301 and 311-328 561276004542 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 561276004543 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 561276004544 Walker A/P-loop; other site 561276004545 ATP binding site [chemical binding]; other site 561276004546 Q-loop/lid; other site 561276004547 ABC transporter signature motif; other site 561276004548 Walker B; other site 561276004549 D-loop; other site 561276004550 H-loop/switch region; other site 561276004555 Protein of unknown function (DUF1603); Region: DUF1603; pfam07674 561276004556 Domain of unknown function (DUF4286); Region: DUF4286; pfam14114 561276004557 site-specific recombinase (pseudogene) 561276004560 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 561276004561 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 561276004563 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 561276004564 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 561276004566 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 561276004567 homodimer interface [polypeptide binding]; other site 561276004568 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 561276004569 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 561276004570 active site 561276004571 homodimer interface [polypeptide binding]; other site 561276004572 catalytic site [active] 561276004576 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 561276004577 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 561276004578 non-specific DNA binding site [nucleotide binding]; other site 561276004579 salt bridge; other site 561276004580 sequence-specific DNA binding site [nucleotide binding]; other site 561276004582 Zeta toxin; Region: Zeta_toxin; pfam06414 561276004583 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 561276004587 uncharacterized protein (pseudogene) 561276004591 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 561276004592 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 561276004593 non-specific DNA binding site [nucleotide binding]; other site 561276004594 salt bridge; other site 561276004595 sequence-specific DNA binding site [nucleotide binding]; other site 561276004596 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 561276004598 Truncation indicated by alignment with homologues and Frameplot; lantibiotic modifying enzyme (pseudogene) 561276004600 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 561276004601 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 561276004602 putative active site [active] 561276004603 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 561276004604 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 561276004605 Walker A/P-loop; other site 561276004606 ATP binding site [chemical binding]; other site 561276004607 Q-loop/lid; other site 561276004608 ABC transporter signature motif; other site 561276004609 Walker B; other site 561276004610 D-loop; other site 561276004611 H-loop/switch region; other site 561276004614 5 transmembrane helices predicted for SPN23F09810 by TMHMM2.0 at aa 161-183, 193-215, 274-293,297-316 and 380-402 561276004618 2 transmembrane helices predicted for SPN23F09820 by TMHMM2.0 at aa 7-29 and 33-51 561276004619 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 561276004620 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 561276004621 Walker A/P-loop; other site 561276004622 ATP binding site [chemical binding]; other site 561276004623 Q-loop/lid; other site 561276004624 ABC transporter signature motif; other site 561276004625 Walker B; other site 561276004626 D-loop; other site 561276004627 H-loop/switch region; other site 561276004630 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4200 561276004631 6 transmembrane helices predicted for SPN23F09840 by TMHMM2.0 at aa 12-34, 60-82, 107-129,149-168, 173-190 and 210-232 561276004632 6 transmembrane helices predicted for SPN23F09850 by TMHMM2.0 at aa 13-35, 50-69, 105-127,137-159, 172-191 and 206-228 561276004634 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 561276004635 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 561276004636 sequence-specific DNA binding site [nucleotide binding]; other site 561276004637 salt bridge; other site 561276004639 transposase (pseudogene) 561276004640 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 561276004642 8 transmembrane helices predicted for SPN23F09880 by TMHMM2.0 at aa 13-35, 50-72, 77-99, 165-187,199-221, 299-321, 333-355 and 365-384 561276004643 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 561276004644 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 561276004648 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 561276004649 zinc binding site [ion binding]; other site 561276004650 putative ligand binding site [chemical binding]; other site 561276004651 1 transmembrane helix predicted for SPN23F09900 by TMHMM2.0 at aa 7-26 561276004653 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 561276004654 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 561276004655 TM-ABC transporter signature motif; other site 561276004657 8 transmembrane helices predicted for SPN23F09910 by TMHMM2.0 at aa 9-28, 55-77, 84-103, 127-146,176-195, 205-227, 232-254 and 259-281 561276004658 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 561276004659 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 561276004660 Walker A/P-loop; other site 561276004661 ATP binding site [chemical binding]; other site 561276004662 Q-loop/lid; other site 561276004663 ABC transporter signature motif; other site 561276004664 Walker B; other site 561276004665 D-loop; other site 561276004666 H-loop/switch region; other site 561276004670 DNA primase; Validated; Region: dnaG; PRK05667 561276004671 CHC2 zinc finger; Region: zf-CHC2; pfam01807 561276004672 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 561276004673 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 561276004674 active site 561276004675 metal binding site [ion binding]; metal-binding site 561276004676 interdomain interaction site; other site 561276004680 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 561276004681 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 561276004682 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 561276004683 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 561276004684 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 561276004685 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 561276004686 DNA binding residues [nucleotide binding] 561276004693 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 561276004695 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 561276004696 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 561276004698 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 561276004699 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 561276004700 putative ADP-binding pocket [chemical binding]; other site 561276004702 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 561276004704 1 transmembrane helix predicted for SPN23F09980 by TMHMM2.0 at aa 29-51 561276004705 Protein of unknown function (DUF4044); Region: DUF4044; pfam13253 561276004706 1 transmembrane helix predicted for SPN23F09990 by TMHMM2.0 at aa 19-41 561276004707 GTPase CgtA; Reviewed; Region: obgE; PRK12297 561276004708 GTP1/OBG; Region: GTP1_OBG; pfam01018 561276004709 Obg GTPase; Region: Obg; cd01898 561276004710 G1 box; other site 561276004711 GTP/Mg2+ binding site [chemical binding]; other site 561276004712 Switch I region; other site 561276004713 G2 box; other site 561276004714 G3 box; other site 561276004715 Switch II region; other site 561276004716 G4 box; other site 561276004717 G5 box; other site 561276004718 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 561276004724 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 561276004725 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 561276004726 hinge; other site 561276004727 active site 561276004730 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 561276004731 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 561276004733 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 561276004734 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 561276004735 DNA-binding site [nucleotide binding]; DNA binding site 561276004736 DRTGG domain; Region: DRTGG; pfam07085 561276004737 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 561276004738 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 561276004739 active site 2 [active] 561276004740 active site 1 [active] 561276004744 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 561276004745 active site 561276004747 IS1381 transposase (pseudogene) 561276004749 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 561276004750 Part of AAA domain; Region: AAA_19; pfam13245 561276004751 Family description; Region: UvrD_C_2; pfam13538 561276004754 hypothetical protein; Reviewed; Region: PRK00024 561276004755 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 561276004756 MPN+ (JAMM) motif; other site 561276004757 Zinc-binding site [ion binding]; other site 561276004760 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 561276004761 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 561276004762 catalytic triad [active] 561276004764 AT-rich DNA-binding protein [General function prediction only]; Region: COG2344 561276004765 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 561276004766 CoA binding domain; Region: CoA_binding; pfam02629 561276004769 Putative amino acid metabolism; Region: DUF1831; pfam08866 561276004771 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 561276004772 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 561276004773 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 561276004774 catalytic residue [active] 561276004777 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458 561276004778 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 561276004779 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 561276004780 active site 561276004782 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 561276004783 putative active site [active] 561276004784 putative metal binding residues [ion binding]; other site 561276004785 signature motif; other site 561276004786 putative triphosphate binding site [ion binding]; other site 561276004788 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 561276004789 synthetase active site [active] 561276004790 NTP binding site [chemical binding]; other site 561276004791 metal binding site [ion binding]; metal-binding site 561276004793 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 561276004794 ATP-NAD kinase; Region: NAD_kinase; pfam01513 561276004796 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 561276004797 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 561276004798 RNA binding surface [nucleotide binding]; other site 561276004799 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 561276004800 active site 561276004803 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 561276004805 IS1167 transposase (pseudogene) 561276004807 hypothetical protein; Validated; Region: PRK00153 561276004810 Predicted membrane protein [Function unknown]; Region: COG3619 561276004812 6 transmembrane helices predicted for SPN23F10250 by TMHMM2.0 at aa 20-38, 70-86, 98-117,127-149, 178-200 and 205-224 561276004813 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 561276004816 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 561276004818 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 561276004821 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 561276004822 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 561276004823 active site 561276004824 Riboflavin kinase; Region: Flavokinase; smart00904 561276004827 Uncharacterized conserved protein [Function unknown]; Region: COG1284 561276004828 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 561276004829 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 561276004830 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 561276004833 EDD domain protein, DegV family; Region: DegV; TIGR00762 561276004834 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 561276004836 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 561276004837 IHF dimer interface [polypeptide binding]; other site 561276004838 IHF - DNA interface [nucleotide binding]; other site 561276004841 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 561276004842 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 561276004843 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 561276004844 ABC transporter; Region: ABC_tran_2; pfam12848 561276004845 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 561276004851 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 561276004852 non-specific DNA binding site [nucleotide binding]; other site 561276004853 salt bridge; other site 561276004854 sequence-specific DNA binding site [nucleotide binding]; other site 561276004855 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 561276004856 H+ Antiporter protein; Region: 2A0121; TIGR00900 561276004857 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 561276004859 10 transmembrane helices predicted for SPN23F10370 by TMHMM2.0 at aa 71-89, 94-116, 137-159,164-183, 218-240, 250-269, 276-295, 299-321, 333-351 and 361-383 561276004860 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 561276004861 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 561276004862 nucleotide binding pocket [chemical binding]; other site 561276004863 K-X-D-G motif; other site 561276004864 catalytic site [active] 561276004865 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 561276004866 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 561276004867 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 561276004868 Dimer interface [polypeptide binding]; other site 561276004869 BRCT sequence motif; other site 561276004876 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cl04227 561276004877 pullulanase, type I; Region: pulA_typeI; TIGR02104 561276004878 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 561276004879 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 561276004880 Ca binding site [ion binding]; other site 561276004881 active site 561276004882 catalytic site [active] 561276004885 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 561276004886 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 561276004887 tetrameric interface [polypeptide binding]; other site 561276004888 activator binding site; other site 561276004889 NADP binding site [chemical binding]; other site 561276004890 substrate binding site [chemical binding]; other site 561276004891 catalytic residues [active] 561276004895 glycogen branching enzyme; Provisional; Region: PRK12313 561276004896 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 561276004897 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 561276004898 active site 561276004899 catalytic site [active] 561276004900 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 561276004904 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 561276004905 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 561276004906 ligand binding site; other site 561276004907 oligomer interface; other site 561276004908 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 561276004909 dimer interface [polypeptide binding]; other site 561276004910 N-terminal domain interface [polypeptide binding]; other site 561276004911 sulfate 1 binding site; other site 561276004914 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 561276004915 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 561276004916 active site 561276004917 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 561276004918 dimer interface [polypeptide binding]; other site 561276004919 N-terminal domain interface [polypeptide binding]; other site 561276004920 sulfate 1 binding site; other site 561276004922 glycogen synthase; Provisional; Region: glgA; PRK00654 561276004923 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 561276004924 ADP-binding pocket [chemical binding]; other site 561276004925 homodimer interface [polypeptide binding]; other site 561276004928 hydrolase (pseudogene) 561276004930 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 561276004931 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 561276004933 Uncharacterized conserved protein [Function unknown]; Region: COG5506 561276004935 enolase; Provisional; Region: eno; PRK00077 561276004936 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 561276004937 dimer interface [polypeptide binding]; other site 561276004938 metal binding site [ion binding]; metal-binding site 561276004939 substrate binding pocket [chemical binding]; other site 561276004943 phage integrase (pseudogene) 561276004945 IS630-Spn1 transposase (pseudogene) 561276004946 1 transmembrane helix predicted for SPN23F10520 by TMHMM2.0 at aa 23-40 561276004948 ATP-dependent nuclease subunit B; Region: rexB_recomb; TIGR02774 561276004949 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 561276004950 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 561276004951 Part of AAA domain; Region: AAA_19; pfam13245 561276004952 Family description; Region: UvrD_C_2; pfam13538 561276004953 Family description; Region: UvrD_C_2; pfam13538 561276004954 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 561276004957 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 561276004958 G5 domain; Region: G5; pfam07501 561276004959 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 561276004960 M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342 561276004961 M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580 561276004963 3 transmembrane helices predicted for SPN23F10580 by TMHMM2.0 at aa 17-36, 106-125 and 132-154 561276004975 G5 domain; Region: G5; pfam07501 561276004976 M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342 561276004977 M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580 561276004978 3 transmembrane helices predicted for SPN23F10590 by TMHMM2.0 at aa 16-38, 78-100 and 109-131 561276004985 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 561276004986 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 561276004987 GTP/Mg2+ binding site [chemical binding]; other site 561276004988 G4 box; other site 561276004989 G5 box; other site 561276004990 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 561276004991 G1 box; other site 561276004992 G1 box; other site 561276004993 GTP/Mg2+ binding site [chemical binding]; other site 561276004994 Switch I region; other site 561276004995 G2 box; other site 561276004996 G2 box; other site 561276004997 G3 box; other site 561276004998 G3 box; other site 561276004999 Switch II region; other site 561276005000 Switch II region; other site 561276005001 G5 box; other site 561276005004 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 561276005005 RNA/DNA hybrid binding site [nucleotide binding]; other site 561276005006 active site 561276005008 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 561276005009 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 561276005010 Cl- selectivity filter; other site 561276005011 Cl- binding residues [ion binding]; other site 561276005012 pore gating glutamate residue; other site 561276005013 dimer interface [polypeptide binding]; other site 561276005014 H+/Cl- coupling transport residue; other site 561276005015 TrkA-C domain; Region: TrkA_C; pfam02080 561276005016 10 transmembrane helices predicted for SPN23F10620 by TMHMM2.0 at aa 24-46, 61-80, 111-133,163-185, 197-219, 234-253, 278-300, 315-337, 344-366 and 376-398 561276005019 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 561276005020 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 561276005021 active site 561276005022 DNA binding site [nucleotide binding] 561276005023 Int/Topo IB signature motif; other site 561276005026 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 561276005027 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 561276005028 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 561276005030 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 561276005031 E3 interaction surface; other site 561276005032 lipoyl attachment site [posttranslational modification]; other site 561276005033 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 561276005034 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 561276005035 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 561276005036 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 561276005043 dihydrolipoamide acetyltransferase; Provisional; Region: PRK14843 561276005044 e3 binding domain; Region: E3_binding; pfam02817 561276005045 e3 binding domain; Region: E3_binding; pfam02817 561276005046 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 561276005050 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 561276005051 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 561276005052 alpha subunit interface [polypeptide binding]; other site 561276005053 TPP binding site [chemical binding]; other site 561276005054 heterodimer interface [polypeptide binding]; other site 561276005055 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 561276005058 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 561276005059 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 561276005060 tetramer interface [polypeptide binding]; other site 561276005061 TPP-binding site [chemical binding]; other site 561276005062 heterodimer interface [polypeptide binding]; other site 561276005063 phosphorylation loop region [posttranslational modification] 561276005065 multidrug efflux protein; Reviewed; Region: PRK01766 561276005066 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 561276005067 cation binding site [ion binding]; other site 561276005070 dihydroorotase; Validated; Region: pyrC; PRK09357 561276005071 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 561276005072 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 561276005073 active site 561276005077 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 561276005078 putative active site [active] 561276005079 nucleotide binding site [chemical binding]; other site 561276005080 nudix motif; other site 561276005081 putative metal binding site [ion binding]; other site 561276005084 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 561276005085 ligand binding site [chemical binding]; other site 561276005086 active site 561276005087 UGI interface [polypeptide binding]; other site 561276005088 catalytic site [active] 561276005091 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 561276005092 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 561276005093 motif II; other site 561276005095 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 561276005097 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 561276005098 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 561276005099 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 561276005100 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 561276005106 1 transmembrane helix predicted for SPN23F10770 by TMHMM2.0 at aa 7-29 561276005107 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 561276005108 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 561276005109 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 561276005110 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 561276005116 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 561276005117 dimerization domain swap beta strand [polypeptide binding]; other site 561276005118 regulatory protein interface [polypeptide binding]; other site 561276005119 active site 561276005120 regulatory phosphorylation site [posttranslational modification]; other site 561276005124 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 561276005125 catalytic residues [active] 561276005127 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 561276005128 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 561276005129 Class I ribonucleotide reductase; Region: RNR_I; cd01679 561276005130 active site 561276005131 dimer interface [polypeptide binding]; other site 561276005132 catalytic residues [active] 561276005133 effector binding site; other site 561276005134 R2 peptide binding site; other site 561276005139 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 561276005140 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 561276005141 dimer interface [polypeptide binding]; other site 561276005142 putative radical transfer pathway; other site 561276005143 diiron center [ion binding]; other site 561276005144 tyrosyl radical; other site 561276005146 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 561276005147 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 561276005148 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 561276005151 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 561276005152 beta-galactosidase; Region: BGL; TIGR03356 561276005157 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 561276005158 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 561276005159 PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565 561276005160 active site 561276005161 P-loop; other site 561276005162 phosphorylation site [posttranslational modification] 561276005165 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 561276005166 methionine cluster; other site 561276005167 active site 561276005168 phosphorylation site [posttranslational modification] 561276005169 metal binding site [ion binding]; metal-binding site 561276005171 CAT RNA binding domain; Region: CAT_RBD; smart01061 561276005172 transcriptional antiterminator BglG; Provisional; Region: PRK09772 561276005173 PRD domain; Region: PRD; pfam00874 561276005174 PRD domain; Region: PRD; pfam00874 561276005178 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 561276005180 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 561276005181 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 561276005182 putative substrate binding site [chemical binding]; other site 561276005183 putative ATP binding site [chemical binding]; other site 561276005187 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 561276005189 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 561276005191 N-terminal truncation due to IS insertion; aldose 1-epimerase 2 (pseudogene) 561276005192 transposase (pseudogene) 561276005193 C-terminal truncation due to IS insertion; sugar phosphotransferase system (PTS),IIB component (pseudogene) 561276005194 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 561276005195 active site 561276005196 phosphorylation site [posttranslational modification] 561276005198 GTP-binding protein LepA; Provisional; Region: PRK05433 561276005199 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 561276005200 G1 box; other site 561276005201 putative GEF interaction site [polypeptide binding]; other site 561276005202 GTP/Mg2+ binding site [chemical binding]; other site 561276005203 Switch I region; other site 561276005204 G2 box; other site 561276005205 G3 box; other site 561276005206 Switch II region; other site 561276005207 G4 box; other site 561276005208 G5 box; other site 561276005209 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 561276005210 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 561276005211 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 561276005218 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 561276005219 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 561276005220 active site 561276005221 metal binding site [ion binding]; metal-binding site 561276005224 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 561276005225 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 561276005226 Walker A/P-loop; other site 561276005227 ATP binding site [chemical binding]; other site 561276005228 Q-loop/lid; other site 561276005229 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 561276005230 ABC transporter signature motif; other site 561276005231 Walker B; other site 561276005232 D-loop; other site 561276005233 H-loop/switch region; other site 561276005236 Arginine repressor [Transcription]; Region: ArgR; COG1438 561276005237 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 561276005238 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 561276005241 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 561276005242 S4 RNA-binding domain; Region: S4; smart00363 561276005243 RNA binding surface [nucleotide binding]; other site 561276005244 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 561276005247 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 561276005248 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 561276005249 substrate binding pocket [chemical binding]; other site 561276005250 chain length determination region; other site 561276005251 substrate-Mg2+ binding site; other site 561276005252 catalytic residues [active] 561276005253 aspartate-rich region 1; other site 561276005254 active site lid residues [active] 561276005255 aspartate-rich region 2; other site 561276005259 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 561276005261 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 561276005262 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 561276005263 generic binding surface II; other site 561276005264 generic binding surface I; other site 561276005267 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 561276005268 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 561276005269 Sugar specificity; other site 561276005270 Pyrimidine base specificity; other site 561276005271 ATP-binding site [chemical binding]; other site 561276005274 Enterocin A Immunity; Region: EntA_Immun; pfam08951 561276005275 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 561276005276 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 561276005277 RNA binding site [nucleotide binding]; other site 561276005278 active site 561276005279 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 561276005281 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 561276005282 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 561276005283 O-acetylhomoserine (thiol)-lyase (pseudogene) 561276005287 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 561276005289 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 561276005290 active site 561276005291 catalytic site [active] 561276005293 1 transmembrane helix predicted for SPN23F11150 by TMHMM2.0 at aa 13-35 561276005294 DNA gyrase subunit A; Validated; Region: PRK05560 561276005295 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 561276005296 CAP-like domain; other site 561276005297 active site 561276005298 primary dimer interface [polypeptide binding]; other site 561276005299 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 561276005300 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 561276005301 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 561276005302 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 561276005303 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 561276005304 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 561276005313 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 561276005314 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 561276005315 tetramer (dimer of dimers) interface [polypeptide binding]; other site 561276005316 NAD binding site [chemical binding]; other site 561276005317 dimer interface [polypeptide binding]; other site 561276005318 substrate binding site [chemical binding]; other site 561276005322 Ion channel; Region: Ion_trans_2; pfam07885 561276005324 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 561276005326 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 561276005327 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 561276005329 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 561276005330 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 561276005331 putative active site [active] 561276005332 heme pocket [chemical binding]; other site 561276005333 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 561276005334 dimer interface [polypeptide binding]; other site 561276005335 phosphorylation site [posttranslational modification] 561276005336 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 561276005337 ATP binding site [chemical binding]; other site 561276005338 Mg2+ binding site [ion binding]; other site 561276005339 G-X-G motif; other site 561276005344 1 transmembrane helix predicted for SPN23F11220 by TMHMM2.0 at aa 13-32 561276005345 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 561276005346 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 561276005347 active site 561276005348 phosphorylation site [posttranslational modification] 561276005349 intermolecular recognition site; other site 561276005350 dimerization interface [polypeptide binding]; other site 561276005351 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 561276005352 DNA binding site [nucleotide binding] 561276005355 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 561276005356 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 561276005357 minor groove reading motif; other site 561276005358 helix-hairpin-helix signature motif; other site 561276005359 substrate binding pocket [chemical binding]; other site 561276005360 active site 561276005361 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 561276005362 DNA binding and oxoG recognition site [nucleotide binding] 561276005365 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 561276005366 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 561276005367 Potassium binding sites [ion binding]; other site 561276005368 Cesium cation binding sites [ion binding]; other site 561276005371 phosphopantothenate--cysteine ligase; Validated; Region: PRK06732 561276005373 phosphopantothenoylcysteine decarboxylase, streptococcal; Region: coaC_strep; TIGR02113 561276005374 Flavoprotein; Region: Flavoprotein; pfam02441 561276005376 Predicted membrane protein [Function unknown]; Region: COG4684 561276005377 6 transmembrane helices predicted for SPN23F11280 by TMHMM2.0 at aa 7-29, 33-52, 59-81, 91-113,120-142 and 157-179 561276005378 5 transmembrane helices predicted for SPN23F11290 by TMHMM2.0 at aa 13-32, 47-69, 76-95, 110-132 and 145-167 561276005379 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 561276005380 HTH domain; Region: HTH_11; pfam08279 561276005381 3H domain; Region: 3H; pfam02829 561276005384 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 561276005385 putative active site [active] 561276005386 nucleotide binding site [chemical binding]; other site 561276005387 nudix motif; other site 561276005388 putative metal binding site [ion binding]; other site 561276005391 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 561276005392 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 561276005393 Coenzyme A binding pocket [chemical binding]; other site 561276005395 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 561276005396 excinuclease ABC subunit B; Provisional; Region: PRK05298 561276005397 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 561276005398 ATP binding site [chemical binding]; other site 561276005399 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 561276005400 nucleotide binding region [chemical binding]; other site 561276005401 ATP-binding site [chemical binding]; other site 561276005402 Ultra-violet resistance protein B; Region: UvrB; pfam12344 561276005403 UvrB/uvrC motif; Region: UVR; pfam02151 561276005408 CAAX protease self-immunity; Region: Abi; pfam02517 561276005410 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 561276005411 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 561276005412 substrate binding pocket [chemical binding]; other site 561276005413 membrane-bound complex binding site; other site 561276005414 hinge residues; other site 561276005415 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 561276005416 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 561276005417 substrate binding pocket [chemical binding]; other site 561276005418 membrane-bound complex binding site; other site 561276005419 hinge residues; other site 561276005420 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 561276005421 dimer interface [polypeptide binding]; other site 561276005422 conserved gate region; other site 561276005423 putative PBP binding loops; other site 561276005424 ABC-ATPase subunit interface; other site 561276005428 3 transmembrane helices predicted for SPN23F11360 by TMHMM2.0 at aa 522-544, 556-578 and 694-713 561276005430 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 561276005431 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 561276005432 Walker A/P-loop; other site 561276005433 ATP binding site [chemical binding]; other site 561276005434 Q-loop/lid; other site 561276005435 ABC transporter signature motif; other site 561276005436 Walker B; other site 561276005437 D-loop; other site 561276005438 H-loop/switch region; other site 561276005442 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 561276005443 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 561276005444 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 561276005448 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 561276005449 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 561276005450 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 561276005451 P loop; other site 561276005452 GTP binding site [chemical binding]; other site 561276005457 sugar phosphate phosphatase; Provisional; Region: PRK10513 561276005458 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 561276005459 motif II; other site 561276005460 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 561276005463 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 561276005464 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 561276005465 active site 561276005466 motif I; other site 561276005467 motif II; other site 561276005468 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 561276005471 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 561276005472 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 561276005473 Walker A/P-loop; other site 561276005474 ATP binding site [chemical binding]; other site 561276005475 Q-loop/lid; other site 561276005476 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 561276005477 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 561276005478 ABC transporter signature motif; other site 561276005479 Walker B; other site 561276005480 D-loop; other site 561276005481 H-loop/switch region; other site 561276005485 ribonuclease III; Reviewed; Region: rnc; PRK00102 561276005486 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 561276005487 dimerization interface [polypeptide binding]; other site 561276005488 active site 561276005489 metal binding site [ion binding]; metal-binding site 561276005490 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 561276005491 dsRNA binding site [nucleotide binding]; other site 561276005495 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 561276005496 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 561276005497 active site 561276005499 McrBC 5-methylcytosine restriction system component [Defense mechanisms]; Region: McrC; COG4268 561276005500 GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401 561276005501 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 561276005502 Walker A motif; other site 561276005503 ATP binding site [chemical binding]; other site 561276005504 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 561276005507 conserved hypothetical protein (pseudogene) 561276005508 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 561276005509 substrate binding site [chemical binding]; other site 561276005511 Predicted membrane protein [Function unknown]; Region: COG3326 561276005513 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 561276005514 tartrate dehydrogenase; Region: TTC; TIGR02089 561276005516 2-isopropylmalate synthase (pseudogene) 561276005519 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 561276005521 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 561276005523 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 561276005525 DNA topoisomerase I; Validated; Region: PRK05582 561276005526 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 561276005527 active site 561276005528 interdomain interaction site; other site 561276005529 putative metal-binding site [ion binding]; other site 561276005530 nucleotide binding site [chemical binding]; other site 561276005531 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 561276005532 domain I; other site 561276005533 DNA binding groove [nucleotide binding] 561276005534 phosphate binding site [ion binding]; other site 561276005535 domain II; other site 561276005536 domain III; other site 561276005537 nucleotide binding site [chemical binding]; other site 561276005538 catalytic site [active] 561276005539 domain IV; other site 561276005540 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 561276005541 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 561276005542 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 561276005548 Predicted membrane protein [Function unknown]; Region: COG1808 561276005550 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 561276005551 DNA protecting protein DprA; Region: dprA; TIGR00732 561276005554 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 561276005555 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 561276005556 active site 561276005557 metal-binding site 561276005561 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 561276005562 Phosphotransferase enzyme family; Region: APH; pfam01636 561276005563 active site 561276005564 substrate binding site [chemical binding]; other site 561276005565 ATP binding site [chemical binding]; other site 561276005566 dimer interface [polypeptide binding]; other site 561276005568 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 561276005569 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 561276005570 putative NAD(P) binding site [chemical binding]; other site 561276005571 putative catalytic Zn binding site [ion binding]; other site 561276005574 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 561276005575 substrate binding site; other site 561276005576 dimer interface; other site 561276005578 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 561276005579 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 561276005581 14 transmembrane helices predicted for SPN23F11660 by TMHMM2.0 at aa 13-32, 47-64, 84-106,116-134, 141-163, 169-191, 208-227, 251-273, 293-315,330-352, 359-381, 386-405, 425-447 and 451-473 561276005582 LicD family; Region: LicD; cl01378 561276005584 LPS biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3475 561276005586 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 561276005587 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 561276005588 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 561276005589 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 561276005590 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 561276005591 ATP-grasp domain; Region: ATP-grasp_4; cl17255 561276005592 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 561276005593 IMP binding site; other site 561276005594 dimer interface [polypeptide binding]; other site 561276005595 interdomain contacts; other site 561276005596 partial ornithine binding site; other site 561276005607 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 561276005608 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 561276005609 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 561276005610 catalytic site [active] 561276005611 subunit interface [polypeptide binding]; other site 561276005615 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 561276005616 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 561276005617 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 561276005621 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 561276005622 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 561276005623 active site 561276005625 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 561276005626 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 561276005627 minor groove reading motif; other site 561276005628 helix-hairpin-helix signature motif; other site 561276005629 substrate binding pocket [chemical binding]; other site 561276005630 active site 561276005633 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 561276005635 uncharacterized protein (pseudogene) 561276005636 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 561276005637 Helix-turn-helix domain; Region: HTH_38; pfam13936 561276005638 Integrase core domain; Region: rve; pfam00665 561276005640 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 561276005641 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 561276005642 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 561276005647 heat shock protein HtpX; Provisional; Region: PRK04897 561276005649 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 561276005651 1 transmembrane helix predicted for SPN23F11790 by TMHMM2.0 at aa 4-23 561276005652 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 561276005653 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 561276005654 S-adenosylmethionine binding site [chemical binding]; other site 561276005656 uracil transporter; Provisional; Region: PRK10720 561276005658 10 transmembrane helices predicted for SPN23F11810 by TMHMM2.0 at aa 32-54, 61-83, 98-120,127-149, 159-176, 183-205, 237-259, 320-342, 347-369 and 381-403 561276005660 signal recognition particle protein; Provisional; Region: PRK10867 561276005661 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 561276005662 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 561276005663 P loop; other site 561276005664 GTP binding site [chemical binding]; other site 561276005665 Signal peptide binding domain; Region: SRP_SPB; pfam02978 561276005671 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 561276005672 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 561276005674 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 561276005676 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 561276005677 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 561276005678 Zn2+ binding site [ion binding]; other site 561276005679 Mg2+ binding site [ion binding]; other site 561276005681 sugar phosphate phosphatase; Provisional; Region: PRK10513 561276005682 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 561276005683 active site 561276005684 motif I; other site 561276005685 motif II; other site 561276005686 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 561276005689 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 561276005692 camphor resistance protein CrcB; Provisional; Region: PRK14229 561276005694 camphor resistance protein CrcB; Provisional; Region: PRK14221 561276005696 hypothetical protein; Provisional; Region: PRK07248 561276005698 flavodoxin; Validated; Region: PRK07308 561276005701 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 561276005702 DHH family; Region: DHH; pfam01368 561276005705 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 561276005708 Appears to be the remnant of a larger CDS found in D39; uncharacterized protein (pseudogene) 561276005709 transposase (pseudogene) 561276005710 glutamate dehydrogenase; Provisional; Region: PRK09414 561276005711 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 561276005712 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 561276005713 NAD(P) binding site [chemical binding]; other site 561276005720 Island encoding alternative ntp synthase 561276005721 transposase (pseudogene) 561276005723 transposase (pseudogene) 561276005725 transposase (pseudogene) 561276005726 IS66 transposase Orf1 pseudogene 561276005728 V-type ATP synthase subunit D; Reviewed; Region: PRK00373 561276005730 V-type ATP synthase subunit B; Provisional; Region: PRK04196 561276005731 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 561276005732 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 561276005733 Walker A motif homologous position; other site 561276005734 Walker B motif; other site 561276005735 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 561276005740 V-type ATP synthase subunit A; Provisional; Region: PRK04192 561276005741 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 561276005742 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 561276005743 Walker A motif/ATP binding site; other site 561276005744 Walker B motif; other site 561276005745 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 561276005751 V-type ATP synthase subunit F; Provisional; Region: PRK01395 561276005753 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 561276005754 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 561276005756 Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390 561276005757 V-type ATP synthase subunit K; Validated; Region: PRK06558 561276005758 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 561276005759 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 561276005762 Archaeal/vacuolar-type H+-ATPase subunit I [Energy production and conversion]; Region: NtpI; COG1269 561276005764 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 561276005765 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 561276005767 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 561276005768 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 561276005769 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 561276005772 Neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: NanH; COG4409 561276005773 Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated...; Region: PTX; cl00102 561276005774 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 561276005775 Asp-box motif; other site 561276005776 catalytic site [active] 561276005783 Domain of unknown function (DUF386); Region: DUF386; pfam04074 561276005785 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 561276005786 Na binding site [ion binding]; other site 561276005788 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 561276005789 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 561276005790 inhibitor site; inhibition site 561276005791 active site 561276005792 dimer interface [polypeptide binding]; other site 561276005793 catalytic residue [active] 561276005795 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 561276005796 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 561276005797 putative active site cavity [active] 561276005799 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 561276005800 Transposase; Region: DDE_Tnp_ISL3; pfam01610 561276005802 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 561276005803 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 561276005804 putative active site [active] 561276005806 5 transmembrane helices predicted for SPN23F12250 by TMHMM2.0 at aa 12-31, 68-90, 103-125,145-164 and 169-191 561276005807 putative transposase OrfB; Reviewed; Region: PHA02517 561276005808 HTH-like domain; Region: HTH_21; pfam13276 561276005809 Integrase core domain; Region: rve; pfam00665 561276005810 Integrase core domain; Region: rve_2; pfam13333 561276005812 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 561276005813 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 561276005814 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 561276005815 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 561276005816 Walker A/P-loop; other site 561276005817 ATP binding site [chemical binding]; other site 561276005818 Q-loop/lid; other site 561276005819 ABC transporter signature motif; other site 561276005820 Walker B; other site 561276005821 D-loop; other site 561276005822 H-loop/switch region; other site 561276005826 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 561276005827 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 561276005828 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 561276005829 Walker A/P-loop; other site 561276005830 ATP binding site [chemical binding]; other site 561276005831 Q-loop/lid; other site 561276005832 ABC transporter signature motif; other site 561276005833 Walker B; other site 561276005834 D-loop; other site 561276005835 H-loop/switch region; other site 561276005841 Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770 561276005842 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 561276005844 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 561276005845 active site 561276005846 ATP binding site [chemical binding]; other site 561276005847 Lanthionine synthetase C-like domain associated with serine threonine kinases. Some members of this subgroup lack the zinc binding site and the active site residues, and therefore are most likely inactive. The function of this domain is unknown; Region: LanC_SerThrkinase; cd04791 561276005848 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 561276005849 active site 561276005850 zinc binding site [ion binding]; other site 561276005852 Small ICE remnant 561276005853 CAAX protease self-immunity; Region: Abi; pfam02517 561276005855 uncharacterized protein (pseudogene) 561276005856 Arsenate reductase and related proteins, glutaredoxin family [Inorganic ion transport and metabolism]; Region: ArsC; COG1393 561276005857 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 561276005859 Integrative and conjugative element 561276005860 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 561276005861 Int/Topo IB signature motif; other site 561276005863 Domain of unknown function (DUF3173); Region: DUF3173; pfam11372 561276005864 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 561276005866 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 561276005868 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 561276005869 Part of AAA domain; Region: AAA_19; pfam13245 561276005870 Family description; Region: UvrD_C_2; pfam13538 561276005871 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 561276005872 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 561276005875 Predicted transcriptional regulator [Transcription]; Region: COG2378 561276005876 WYL domain; Region: WYL; pfam13280 561276005877 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 561276005878 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 561276005881 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 561276005882 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 561276005883 active site 561276005884 motif I; other site 561276005885 motif II; other site 561276005886 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 561276005887 HD domain; Region: HD_4; pfam13328 561276005888 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 561276005889 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 561276005890 Replication protein; Region: Rep_1; cl02412 561276005892 Chloramphenicol acetyltransferase; Region: CAT; pfam00302 561276005893 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 561276005896 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 561276005897 GIY-YIG motif/motif A; other site 561276005898 active site 561276005899 catalytic site [active] 561276005900 Zeta toxin; Region: Zeta_toxin; pfam06414 561276005901 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 561276005902 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 561276005906 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 561276005907 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 561276005908 non-specific DNA binding site [nucleotide binding]; other site 561276005909 salt bridge; other site 561276005910 sequence-specific DNA binding site [nucleotide binding]; other site 561276005912 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 561276005913 Toprim-like; Region: Toprim_2; pfam13155 561276005914 1 transmembrane helix predicted for SPN23F12680 by TMHMM2.0 at aa 9-31 561276005915 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 561276005916 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 561276005917 putative active site [active] 561276005918 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 561276005919 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 561276005920 Walker A/P-loop; other site 561276005921 ATP binding site [chemical binding]; other site 561276005922 Q-loop/lid; other site 561276005923 ABC transporter signature motif; other site 561276005924 Walker B; other site 561276005925 D-loop; other site 561276005926 H-loop/switch region; other site 561276005932 type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897 561276005933 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 561276005934 active site 561276005935 zinc binding site [ion binding]; other site 561276005937 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 561276005938 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 561276005939 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 561276005940 Walker A/P-loop; other site 561276005941 ATP binding site [chemical binding]; other site 561276005942 Q-loop/lid; other site 561276005943 ABC transporter signature motif; other site 561276005944 Walker B; other site 561276005945 D-loop; other site 561276005946 H-loop/switch region; other site 561276005950 1 transmembrane helix predicted for SPN23F12740 by TMHMM2.0 at aa 7-26 561276005951 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 561276005952 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 561276005953 non-specific DNA binding site [nucleotide binding]; other site 561276005954 salt bridge; other site 561276005955 sequence-specific DNA binding site [nucleotide binding]; other site 561276005957 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 561276005958 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 561276005959 putative active site [active] 561276005960 putative NTP binding site [chemical binding]; other site 561276005961 putative nucleic acid binding site [nucleotide binding]; other site 561276005962 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 561276005963 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 561276005964 Type II intron maturase; Region: Intron_maturas2; pfam01348 561276005965 HNH endonuclease; Region: HNH; pfam01844 561276005971 uncharacterized protein (pseudogene) 561276005972 Peptidase family M23; Region: Peptidase_M23; pfam01551 561276005973 CHAP domain; Region: CHAP; pfam05257 561276005976 1 transmembrane helix predicted for SPN23F12840 by TMHMM2.0 at aa 299-321 561276005977 AAA-like domain; Region: AAA_10; pfam12846 561276005978 PrgI family protein; Region: PrgI; pfam12666 561276005979 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 561276005980 AAA-like domain; Region: AAA_10; pfam12846 561276005981 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 561276005982 Walker A motif; other site 561276005983 ATP binding site [chemical binding]; other site 561276005984 Walker B motif; other site 561276005987 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 561276005989 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 561276005990 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 561276005992 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 561276005994 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 561276005995 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 561276005996 Walker A motif; other site 561276005997 ATP binding site [chemical binding]; other site 561276005998 Walker B motif; other site 561276005999 arginine finger; other site 561276006000 2 transmembrane helices predicted for SPN23F12960 by TMHMM2.0 at aa 15-37 and 58-79 561276006003 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 561276006004 non-specific DNA binding site [nucleotide binding]; other site 561276006005 salt bridge; other site 561276006006 sequence-specific DNA binding site [nucleotide binding]; other site 561276006007 Replication initiation factor; Region: Rep_trans; pfam02486 561276006010 2 transmembrane helices predicted for SPN23F12980 by TMHMM2.0 at aa 10-32 and 39-58 561276006011 Antirestriction protein (ArdA); Region: ArdA; pfam07275 561276006013 TcpE family; Region: TcpE; pfam12648 561276006014 AAA-like domain; Region: AAA_10; pfam12846 561276006016 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 561276006017 Haemolysin-III related; Region: HlyIII; cl03831 561276006018 8 transmembrane helices predicted for SPN23F13020 by TMHMM2.0 at aa 21-43, 91-113, 154-176,186-203, 320-342, 347-369, 382-404 and 408-430 561276006019 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 561276006020 N-acetyl-D-glucosamine binding site [chemical binding]; other site 561276006021 catalytic residue [active] 561276006022 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 561276006023 NlpC/P60 family; Region: NLPC_P60; pfam00877 561276006024 1 transmembrane helix predicted for SPN23F13030 by TMHMM2.0 at aa 7-29 561276006026 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 561276006027 1 transmembrane helix predicted for SPN23F13040 by TMHMM2.0 at aa 31-48 561276006028 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 561276006029 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 561276006030 G1 box; other site 561276006031 putative GEF interaction site [polypeptide binding]; other site 561276006032 GTP/Mg2+ binding site [chemical binding]; other site 561276006033 Switch I region; other site 561276006034 G2 box; other site 561276006035 G3 box; other site 561276006036 Switch II region; other site 561276006037 G4 box; other site 561276006038 G5 box; other site 561276006039 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 561276006040 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 561276006041 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 561276006048 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 561276006049 non-specific DNA binding site [nucleotide binding]; other site 561276006050 salt bridge; other site 561276006051 sequence-specific DNA binding site [nucleotide binding]; other site 561276006053 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 561276006054 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 561276006055 DNA binding residues [nucleotide binding] 561276006057 Excisionase from transposon Tn916; Region: Tn916-Xis; pfam09035 561276006059 integrase (pseudogene) 561276006063 CAAX protease self-immunity; Region: Abi; pfam02517 561276006065 Arsenate reductase and related proteins, glutaredoxin family [Inorganic ion transport and metabolism]; Region: ArsC; COG1393 561276006066 ArsC family; Region: ArsC; pfam03960 561276006067 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 561276006068 cofactor binding site; other site 561276006069 DNA binding site [nucleotide binding] 561276006070 substrate interaction site [chemical binding]; other site 561276006071 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 561276006076 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 561276006078 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 561276006079 core dimer interface [polypeptide binding]; other site 561276006080 L10 interface [polypeptide binding]; other site 561276006081 L11 interface [polypeptide binding]; other site 561276006082 putative EF-Tu interaction site [polypeptide binding]; other site 561276006083 putative EF-G interaction site [polypeptide binding]; other site 561276006085 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 561276006086 23S rRNA interface [nucleotide binding]; other site 561276006087 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 561276006089 chlorohydrolase; Validated; Region: PRK06687 561276006090 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 561276006091 active site 561276006092 putative substrate binding pocket [chemical binding]; other site 561276006094 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 561276006095 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 561276006096 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 561276006097 Walker A/P-loop; other site 561276006098 ATP binding site [chemical binding]; other site 561276006099 Q-loop/lid; other site 561276006100 ABC transporter signature motif; other site 561276006101 Walker B; other site 561276006102 D-loop; other site 561276006103 H-loop/switch region; other site 561276006108 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 561276006109 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 561276006110 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 561276006111 Walker A/P-loop; other site 561276006112 ATP binding site [chemical binding]; other site 561276006113 Q-loop/lid; other site 561276006114 ABC transporter signature motif; other site 561276006115 Walker B; other site 561276006116 D-loop; other site 561276006117 H-loop/switch region; other site 561276006122 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 561276006123 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 561276006124 SelR domain; Region: SelR; pfam01641 561276006127 homoserine kinase; Provisional; Region: PRK01212 561276006128 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 561276006132 homoserine dehydrogenase; Provisional; Region: PRK06349 561276006133 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 561276006134 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 561276006135 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 561276006140 adaptor protein; Provisional; Region: PRK02315 561276006142 O-antigen polysaccharide polymerase Wzy; Region: O-ag_pol_Wzy; pfam14296 561276006143 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 561276006144 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 561276006145 active site 561276006146 1 transmembrane helix predicted for SPN23F13310 by TMHMM2.0 at aa 301-318 561276006148 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 561276006149 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 561276006150 putative ADP-binding pocket [chemical binding]; other site 561276006152 LPS biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3475 561276006154 Transcriptional regulator [Transcription]; Region: LytR; COG1316 561276006156 1 transmembrane helix predicted for SPN23F13340 by TMHMM2.0 at aa 93-115 561276006157 prephenate dehydratase; Provisional; Region: PRK11898 561276006158 Prephenate dehydratase; Region: PDT; pfam00800 561276006159 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 561276006160 putative L-Phe binding site [chemical binding]; other site 561276006163 shikimate kinase; Reviewed; Region: aroK; PRK00131 561276006164 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 561276006165 ADP binding site [chemical binding]; other site 561276006166 magnesium binding site [ion binding]; other site 561276006167 putative shikimate binding site; other site 561276006171 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 561276006172 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 561276006173 hinge; other site 561276006174 active site 561276006178 hypothetical protein; Provisional; Region: PRK13676 561276006180 prephenate dehydrogenase; Validated; Region: PRK06545 561276006181 prephenate dehydrogenase; Validated; Region: PRK08507 561276006182 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 561276006184 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 561276006185 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 561276006186 Tetramer interface [polypeptide binding]; other site 561276006187 active site 561276006188 FMN-binding site [chemical binding]; other site 561276006192 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 561276006193 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 561276006194 active site 561276006195 dimer interface [polypeptide binding]; other site 561276006196 metal binding site [ion binding]; metal-binding site 561276006198 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 561276006199 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 561276006200 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 561276006201 shikimate binding site; other site 561276006202 NAD(P) binding site [chemical binding]; other site 561276006205 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 561276006206 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 561276006207 active site 561276006208 catalytic residue [active] 561276006209 dimer interface [polypeptide binding]; other site 561276006211 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 561276006212 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 561276006213 putative RNA binding site [nucleotide binding]; other site 561276006214 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 561276006215 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 561276006216 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 561276006217 Walker A/P-loop; other site 561276006218 ATP binding site [chemical binding]; other site 561276006219 Q-loop/lid; other site 561276006220 ABC transporter signature motif; other site 561276006221 Walker B; other site 561276006222 D-loop; other site 561276006223 H-loop/switch region; other site 561276006227 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 561276006228 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 561276006229 active site 561276006230 Na/Ca binding site [ion binding]; other site 561276006231 catalytic site [active] 561276006232 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 561276006234 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 561276006235 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 561276006236 motif 1; other site 561276006237 active site 561276006238 motif 2; other site 561276006239 motif 3; other site 561276006240 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 561276006241 DHHA1 domain; Region: DHHA1; pfam02272 561276006246 Uncharacterized conserved protein [Function unknown]; Region: COG4894 561276006248 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 561276006249 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 561276006251 1 transmembrane helix predicted for SPN23F13500 by TMHMM2.0 at aa 5-22 561276006252 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 561276006253 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 561276006254 dimer interface [polypeptide binding]; other site 561276006255 conserved gate region; other site 561276006256 putative PBP binding loops; other site 561276006257 ABC-ATPase subunit interface; other site 561276006259 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 561276006260 dimer interface [polypeptide binding]; other site 561276006261 conserved gate region; other site 561276006262 putative PBP binding loops; other site 561276006263 ABC-ATPase subunit interface; other site 561276006265 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 561276006266 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 561276006267 Walker A/P-loop; other site 561276006268 ATP binding site [chemical binding]; other site 561276006269 Q-loop/lid; other site 561276006270 ABC transporter signature motif; other site 561276006271 Walker B; other site 561276006272 D-loop; other site 561276006273 H-loop/switch region; other site 561276006274 TOBE domain; Region: TOBE_2; pfam08402 561276006279 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 561276006280 FAD binding domain; Region: FAD_binding_4; pfam01565 561276006281 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 561276006284 Predicted membrane protein [Function unknown]; Region: COG4377 561276006285 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 561276006287 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 561276006288 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 561276006289 DNA-binding site [nucleotide binding]; DNA binding site 561276006290 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 561276006291 pyridoxal 5'-phosphate binding site [chemical binding]; other site 561276006292 homodimer interface [polypeptide binding]; other site 561276006293 catalytic residue [active] 561276006295 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 561276006296 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 561276006297 substrate binding pocket [chemical binding]; other site 561276006298 membrane-bound complex binding site; other site 561276006299 hinge residues; other site 561276006302 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 561276006303 PhoU domain; Region: PhoU; pfam01895 561276006304 PhoU domain; Region: PhoU; pfam01895 561276006307 phosphate transporter ATP-binding protein; Provisional; Region: PRK14239 561276006308 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 561276006309 Walker A/P-loop; other site 561276006310 ATP binding site [chemical binding]; other site 561276006311 Q-loop/lid; other site 561276006312 ABC transporter signature motif; other site 561276006313 Walker B; other site 561276006314 D-loop; other site 561276006315 H-loop/switch region; other site 561276006319 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 561276006320 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 561276006321 Walker A/P-loop; other site 561276006322 ATP binding site [chemical binding]; other site 561276006323 Q-loop/lid; other site 561276006324 ABC transporter signature motif; other site 561276006325 Walker B; other site 561276006326 D-loop; other site 561276006327 H-loop/switch region; other site 561276006331 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 561276006332 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 561276006333 dimer interface [polypeptide binding]; other site 561276006334 conserved gate region; other site 561276006335 putative PBP binding loops; other site 561276006336 ABC-ATPase subunit interface; other site 561276006339 potential frameshift: common BLAST hit: gi|194396785|ref|YP_002038047.1| phosphate ABC transporter permease 561276006340 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 561276006341 ABC-ATPase subunit interface; other site 561276006344 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 561276006345 conserved gate region; other site 561276006347 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 561276006348 phosphate binding protein; Region: ptsS_2; TIGR02136 561276006351 1 transmembrane helix predicted for SPN23F13650 by TMHMM2.0 at aa 7-29 561276006353 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 561276006354 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 561276006355 S-adenosylmethionine binding site [chemical binding]; other site 561276006356 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 561276006359 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 561276006360 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 561276006361 active site 561276006363 Uncharacterized protein family (UPF0223); Region: UPF0223; cl11484 561276006365 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 561276006366 ArsC family; Region: ArsC; pfam03960 561276006367 putative catalytic residues [active] 561276006368 thiol/disulfide switch; other site 561276006370 Predicted membrane protein [Function unknown]; Region: COG4478 561276006372 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 561276006373 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 561276006374 active site 561276006375 motif I; other site 561276006376 motif II; other site 561276006377 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 561276006379 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 561276006380 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 561276006381 active site 561276006382 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 561276006383 active site 561276006385 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 561276006386 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 561276006387 FeS/SAM binding site; other site 561276006388 HemN C-terminal domain; Region: HemN_C; pfam06969 561276006391 YtxH-like protein; Region: YtxH; pfam12732 561276006392 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 561276006394 1 transmembrane helix predicted for SPN23F13760 by TMHMM2.0 at aa 4-22 561276006395 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 561276006398 HPr kinase/phosphorylase; Provisional; Region: PRK05428 561276006399 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 561276006400 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 561276006401 Hpr binding site; other site 561276006402 active site 561276006403 homohexamer subunit interaction site [polypeptide binding]; other site 561276006407 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 561276006410 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 561276006411 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 561276006412 active site 561276006413 trimer interface [polypeptide binding]; other site 561276006414 allosteric site; other site 561276006415 active site lid [active] 561276006416 hexamer (dimer of trimers) interface [polypeptide binding]; other site 561276006418 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 561276006419 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 561276006421 choline binding protein (pseudogene) 561276006425 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 561276006426 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 561276006428 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 561276006429 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 561276006430 homodimer interface [polypeptide binding]; other site 561276006431 NAD binding pocket [chemical binding]; other site 561276006432 ATP binding pocket [chemical binding]; other site 561276006433 Mg binding site [ion binding]; other site 561276006434 active-site loop [active] 561276006436 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 561276006437 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 561276006438 active site 561276006440 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 561276006441 non-specific DNA binding site [nucleotide binding]; other site 561276006442 salt bridge; other site 561276006443 sequence-specific DNA binding site [nucleotide binding]; other site 561276006445 ABC transporter ATP-binding protein (pseudogene) 561276006447 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 561276006448 Peptidase family U32; Region: Peptidase_U32; pfam01136 561276006449 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 561276006451 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 561276006452 Peptidase family U32; Region: Peptidase_U32; pfam01136 561276006455 restriction endonuclease (pseudogene) 561276006456 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 561276006457 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 561276006458 S-adenosylmethionine binding site [chemical binding]; other site 561276006461 Helix-turn-helix domain; Region: HTH_18; pfam12833 561276006462 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 561276006465 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 561276006466 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 561276006467 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 561276006468 Walker A/P-loop; other site 561276006469 ATP binding site [chemical binding]; other site 561276006470 Q-loop/lid; other site 561276006471 ABC transporter signature motif; other site 561276006472 Walker B; other site 561276006473 D-loop; other site 561276006474 H-loop/switch region; other site 561276006476 5 transmembrane helices predicted for SPN23F13990 by TMHMM2.0 at aa 17-39, 63-85, 146-168,243-265 and 272-291 561276006480 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 561276006481 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 561276006482 Walker A/P-loop; other site 561276006483 ATP binding site [chemical binding]; other site 561276006484 Q-loop/lid; other site 561276006485 ABC transporter signature motif; other site 561276006486 Walker B; other site 561276006487 D-loop; other site 561276006488 H-loop/switch region; other site 561276006489 5 transmembrane helices predicted for SPN23F14000 by TMHMM2.0 at aa 22-44, 54-76, 137-154,159-176 and 240-262 561276006493 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 561276006494 6 transmembrane helices predicted for SPN23F14010 by TMHMM2.0 at aa 12-34, 38-57, 64-81, 85-104,111-133 and 157-179 561276006495 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 561276006497 4 transmembrane helices predicted for SPN23F14020 by TMHMM2.0 at aa 28-50, 57-75, 85-107 and 208-230 561276006498 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 561276006499 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 561276006500 Walker A/P-loop; other site 561276006501 ATP binding site [chemical binding]; other site 561276006502 Q-loop/lid; other site 561276006503 ABC transporter signature motif; other site 561276006504 Walker B; other site 561276006505 D-loop; other site 561276006506 H-loop/switch region; other site 561276006507 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 561276006508 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 561276006509 Walker A/P-loop; other site 561276006510 ATP binding site [chemical binding]; other site 561276006511 Q-loop/lid; other site 561276006512 ABC transporter signature motif; other site 561276006513 Walker B; other site 561276006514 D-loop; other site 561276006515 H-loop/switch region; other site 561276006521 transposase remnant (pseudogene) 561276006522 transposase remnant (pseudogene) 561276006523 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 561276006524 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 561276006526 GMP synthase; Reviewed; Region: guaA; PRK00074 561276006527 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 561276006528 AMP/PPi binding site [chemical binding]; other site 561276006529 candidate oxyanion hole; other site 561276006530 catalytic triad [active] 561276006531 potential glutamine specificity residues [chemical binding]; other site 561276006532 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 561276006533 ATP Binding subdomain [chemical binding]; other site 561276006534 Dimerization subdomain; other site 561276006539 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 561276006540 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 561276006541 DNA-binding site [nucleotide binding]; DNA binding site 561276006542 UTRA domain; Region: UTRA; pfam07702 561276006546 EamA-like transporter family; Region: EamA; pfam00892 561276006550 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 561276006551 Beta-lactamase; Region: Beta-lactamase; pfam00144 561276006554 NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841 561276006555 active site 561276006556 catalytic triad [active] 561276006557 oxyanion hole [active] 561276006559 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 561276006560 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 561276006561 active site 561276006562 motif I; other site 561276006563 motif II; other site 561276006564 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 561276006566 membrane protein (pseudogene) 561276006567 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 561276006568 active site 561276006569 catalytic residues [active] 561276006570 metal binding site [ion binding]; metal-binding site 561276006572 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 561276006573 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 561276006574 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 561276006577 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 561276006578 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 561276006579 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 561276006583 Protein of unknown function (DUF4059); Region: DUF4059; pfam13268 561276006584 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 561276006585 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 561276006586 Walker A/P-loop; other site 561276006587 ATP binding site [chemical binding]; other site 561276006588 Q-loop/lid; other site 561276006589 ABC transporter signature motif; other site 561276006590 Walker B; other site 561276006591 D-loop; other site 561276006592 H-loop/switch region; other site 561276006596 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 561276006597 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 561276006598 ABC-ATPase subunit interface; other site 561276006599 putative PBP binding loops; other site 561276006602 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 561276006603 putative ArsC-like catalytic residues; other site 561276006604 putative TRX-like catalytic residues [active] 561276006606 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 561276006607 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 561276006608 DNA binding site [nucleotide binding] 561276006609 active site 561276006612 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 561276006613 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 561276006615 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 561276006617 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 561276006618 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 561276006620 7 transmembrane helices predicted for SPN23F14300 by TMHMM2.0 at aa 20-42, 47-69, 90-107,111-133, 140-162, 166-185 and 192-214 561276006621 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 561276006622 predicted active site [active] 561276006623 catalytic triad [active] 561276006626 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 561276006627 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 561276006628 active site 561276006629 multimer interface [polypeptide binding]; other site 561276006632 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 561276006633 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 561276006634 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 561276006639 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 561276006640 ApbE family; Region: ApbE; pfam02424 561276006642 Predicted flavoprotein [General function prediction only]; Region: COG0431 561276006643 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 561276006645 Predicted flavoprotein [General function prediction only]; Region: COG0431 561276006646 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 561276006647 PAS domain; Region: PAS_10; pfam13596 561276006649 hypothetical protein; Provisional; Region: PRK02539 561276006651 Glycyl-tRNA synthetase, beta subunit [Translation, ribosomal structure and biogenesis]; Region: GlyS; COG0751 561276006652 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 561276006653 DALR anticodon binding domain; Region: DALR_1; pfam05746 561276006656 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 561276006657 dimer interface [polypeptide binding]; other site 561276006658 motif 1; other site 561276006659 active site 561276006660 motif 2; other site 561276006661 motif 3; other site 561276006664 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 561276006666 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 561276006667 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 561276006668 active site 561276006669 catalytic tetrad [active] 561276006673 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 561276006674 Catalytic NodB homology domain of Streptococcus pneumoniae peptidoglycan deacetylase PgdA, Bacillus subtilis BsYjeA protein, and their bacterial homologs; Region: CE4_SpPgdA_BsYjeA_like; cd10947 561276006675 NodB motif; other site 561276006676 active site 561276006677 catalytic site [active] 561276006678 Zn binding site [ion binding]; other site 561276006680 1 transmembrane helix predicted for SPN23F14430 by TMHMM2.0 at aa 2-24 561276006681 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 561276006682 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 561276006683 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 561276006685 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 561276006686 DEAD-like helicases superfamily; Region: DEXDc; smart00487 561276006687 ATP binding site [chemical binding]; other site 561276006688 putative Mg++ binding site [ion binding]; other site 561276006689 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 561276006690 nucleotide binding region [chemical binding]; other site 561276006691 ATP-binding site [chemical binding]; other site 561276006694 transposase (pseudogene) 561276006695 IS1167 transposase (pseudogene) 561276006697 elongation factor Tu; Reviewed; Region: PRK00049 561276006698 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 561276006699 G1 box; other site 561276006700 GEF interaction site [polypeptide binding]; other site 561276006701 GTP/Mg2+ binding site [chemical binding]; other site 561276006702 Switch I region; other site 561276006703 G2 box; other site 561276006704 G3 box; other site 561276006705 Switch II region; other site 561276006706 G4 box; other site 561276006707 G5 box; other site 561276006708 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 561276006709 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 561276006710 Antibiotic Binding Site [chemical binding]; other site 561276006716 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 561276006717 Helix-turn-helix domain; Region: HTH_38; pfam13936 561276006718 Integrase core domain; Region: rve; pfam00665 561276006720 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 561276006721 amphipathic channel; other site 561276006722 Asn-Pro-Ala signature motifs; other site 561276006725 sortase-sorted surface anchored protein (pseudogene) 561276006729 transposase (pseudogene) 561276006731 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 561276006732 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 561276006733 active site 561276006734 substrate binding site [chemical binding]; other site 561276006735 metal binding site [ion binding]; metal-binding site 561276006741 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 561276006742 catalytic residues [active] 561276006743 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 561276006744 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 561276006745 substrate binding pocket [chemical binding]; other site 561276006746 membrane-bound complex binding site; other site 561276006747 hinge residues; other site 561276006750 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 561276006751 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 561276006752 Walker A/P-loop; other site 561276006753 ATP binding site [chemical binding]; other site 561276006754 Q-loop/lid; other site 561276006755 ABC transporter signature motif; other site 561276006756 Walker B; other site 561276006757 D-loop; other site 561276006758 H-loop/switch region; other site 561276006762 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 561276006763 dimer interface [polypeptide binding]; other site 561276006764 conserved gate region; other site 561276006765 putative PBP binding loops; other site 561276006766 ABC-ATPase subunit interface; other site 561276006768 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 561276006769 TPR motif; other site 561276006770 binding surface 561276006771 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 561276006772 binding surface 561276006773 TPR motif; other site 561276006775 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 561276006776 Domain of unknown function DUF20; Region: UPF0118; pfam01594 561276006778 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 561276006779 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 561276006780 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 561276006781 gamma subunit interface [polypeptide binding]; other site 561276006782 epsilon subunit interface [polypeptide binding]; other site 561276006783 LBP interface [polypeptide binding]; other site 561276006786 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 561276006787 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 561276006788 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 561276006789 alpha subunit interaction interface [polypeptide binding]; other site 561276006790 Walker A motif; other site 561276006791 ATP binding site [chemical binding]; other site 561276006792 Walker B motif; other site 561276006793 inhibitor binding site; inhibition site 561276006794 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 561276006800 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 561276006801 core domain interface [polypeptide binding]; other site 561276006802 delta subunit interface [polypeptide binding]; other site 561276006803 epsilon subunit interface [polypeptide binding]; other site 561276006806 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 561276006807 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 561276006808 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 561276006809 beta subunit interaction interface [polypeptide binding]; other site 561276006810 Walker A motif; other site 561276006811 ATP binding site [chemical binding]; other site 561276006812 Walker B motif; other site 561276006813 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 561276006819 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 561276006820 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 561276006822 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 561276006823 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 561276006825 1 transmembrane helix predicted for SPN23F14760 by TMHMM2.0 at aa 4-26 561276006826 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 561276006827 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 561276006829 F0F1 ATP synthase subunit C; Provisional; Region: PRK13467 561276006832 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 561276006833 Helix-turn-helix domain; Region: HTH_38; pfam13936 561276006834 Integrase core domain; Region: rve; pfam00665 561276006836 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 561276006837 Coenzyme A binding pocket [chemical binding]; other site 561276006839 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 561276006840 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 561276006841 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 561276006845 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 561276006846 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 561276006847 dimerization interface [polypeptide binding]; other site 561276006849 1 transmembrane helix predicted for SPN23F14820 by TMHMM2.0 at aa 189-211 561276006850 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 561276006851 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 561276006852 Coenzyme A binding pocket [chemical binding]; other site 561276006854 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 561276006855 Coenzyme A binding pocket [chemical binding]; other site 561276006857 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 561276006858 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 561276006859 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 561276006860 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 561276006865 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 561276006866 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 561276006867 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 561276006868 ATP binding site [chemical binding]; other site 561276006869 putative Mg++ binding site [ion binding]; other site 561276006870 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 561276006871 nucleotide binding region [chemical binding]; other site 561276006872 ATP-binding site [chemical binding]; other site 561276006878 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 561276006879 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 561276006880 pyridoxal 5'-phosphate binding site [chemical binding]; other site 561276006881 homodimer interface [polypeptide binding]; other site 561276006882 catalytic residue [active] 561276006884 cystathionine gamma-synthase; Reviewed; Region: PRK07269 561276006885 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 561276006886 homodimer interface [polypeptide binding]; other site 561276006887 substrate-cofactor binding pocket; other site 561276006888 pyridoxal 5'-phosphate binding site [chemical binding]; other site 561276006889 catalytic residue [active] 561276006892 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 561276006893 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 561276006894 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 561276006895 Walker A/P-loop; other site 561276006896 ATP binding site [chemical binding]; other site 561276006897 Q-loop/lid; other site 561276006898 ABC transporter signature motif; other site 561276006899 Walker B; other site 561276006900 D-loop; other site 561276006901 H-loop/switch region; other site 561276006906 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 561276006907 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 561276006908 peptide binding site [polypeptide binding]; other site 561276006912 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 561276006913 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 561276006915 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 561276006916 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 561276006917 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 561276006918 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 561276006921 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237 561276006923 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 561276006924 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 561276006928 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 561276006929 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 561276006930 DHH family; Region: DHH; pfam01368 561276006931 DHHA2 domain; Region: DHHA2; pfam02833 561276006934 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 561276006935 GIY-YIG motif/motif A; other site 561276006936 putative active site [active] 561276006937 putative metal binding site [ion binding]; other site 561276006939 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 561276006940 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 561276006941 S-adenosylmethionine binding site [chemical binding]; other site 561276006944 hypothetical protein; Provisional; Region: PRK07252 561276006945 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 561276006946 RNA binding site [nucleotide binding]; other site 561276006948 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 561276006949 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 561276006950 active site 561276006951 motif I; other site 561276006952 motif II; other site 561276006953 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 561276006954 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 561276006955 active site 561276006960 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 561276006963 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 561276006964 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 561276006965 dimer interface [polypeptide binding]; other site 561276006966 ssDNA binding site [nucleotide binding]; other site 561276006967 tetramer (dimer of dimers) interface [polypeptide binding]; other site 561276006969 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 561276006971 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 561276006972 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 561276006973 putative dimer interface [polypeptide binding]; other site 561276006974 putative anticodon binding site; other site 561276006975 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 561276006976 homodimer interface [polypeptide binding]; other site 561276006977 motif 1; other site 561276006978 motif 2; other site 561276006979 active site 561276006980 motif 3; other site 561276006985 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 561276006986 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 561276006988 aspartate aminotransferase; Provisional; Region: PRK05764 561276006989 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 561276006990 pyridoxal 5'-phosphate binding site [chemical binding]; other site 561276006991 homodimer interface [polypeptide binding]; other site 561276006992 catalytic residue [active] 561276006995 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 561276006997 1 transmembrane helix predicted for SPN23F15080 by TMHMM2.0 at aa 12-34 561276006998 Predicted flavoprotein [General function prediction only]; Region: COG0431 561276006999 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 561276007001 G5 domain; Region: G5; pfam07501 561276007002 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 561276007003 Streptococcal surface-anchored protein repeat, S. criceti family; Region: RPT_S_cricet; TIGR04203 561276007004 Streptococcal surface-anchored protein repeat, S. criceti family; Region: RPT_S_cricet; TIGR04203 561276007005 Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391 561276007006 Streptococcal surface-anchored protein repeat, S. criceti family; Region: RPT_S_cricet; TIGR04203 561276007007 Streptococcal surface-anchored protein repeat, S. criceti family; Region: RPT_S_cricet; TIGR04203 561276007008 Streptococcal surface-anchored protein repeat, S. criceti family; Region: RPT_S_cricet; TIGR04203 561276007009 Streptococcal surface-anchored protein repeat, S. criceti family; Region: RPT_S_cricet; TIGR04203 561276007010 Streptococcal surface-anchored protein repeat, S. criceti family; Region: RPT_S_cricet; TIGR04203 561276007011 Streptococcal surface-anchored protein repeat, S. criceti family; Region: RPT_S_cricet; TIGR04203 561276007019 1 transmembrane helix predicted for SPN23F15110 by TMHMM2.0 at aa 23-45 561276007021 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 561276007022 Mga helix-turn-helix domain; Region: Mga; pfam05043 561276007023 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 561276007027 hypothetical protein; Validated; Region: PRK02101 561276007029 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 561276007030 active site 561276007031 catalytic residues [active] 561276007032 metal binding site [ion binding]; metal-binding site 561276007034 putative S-transferase; Provisional; Region: PRK11752 561276007035 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 561276007036 C-terminal domain interface [polypeptide binding]; other site 561276007037 GSH binding site (G-site) [chemical binding]; other site 561276007038 dimer interface [polypeptide binding]; other site 561276007039 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 561276007040 N-terminal domain interface [polypeptide binding]; other site 561276007041 dimer interface [polypeptide binding]; other site 561276007042 substrate binding pocket (H-site) [chemical binding]; other site 561276007045 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 561276007046 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 561276007047 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 561276007048 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 561276007049 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 561276007050 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 561276007056 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 561276007057 Cation efflux family; Region: Cation_efflux; pfam01545 561276007058 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 561276007059 5 transmembrane helices predicted for SPN23F15190 by TMHMM2.0 at aa 13-35, 40-62, 83-100, 115-137 and 183-201 561276007061 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 561276007062 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 561276007063 Walker A/P-loop; other site 561276007064 ATP binding site [chemical binding]; other site 561276007065 Q-loop/lid; other site 561276007066 ABC transporter signature motif; other site 561276007067 Walker B; other site 561276007068 D-loop; other site 561276007069 H-loop/switch region; other site 561276007070 ABC transporter; Region: ABC_tran_2; pfam12848 561276007071 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 561276007076 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 561276007077 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 561276007078 active site 561276007079 NTP binding site [chemical binding]; other site 561276007080 metal binding triad [ion binding]; metal-binding site 561276007081 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 561276007082 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 561276007084 dihydrodipicolinate reductase; Provisional; Region: PRK00048 561276007085 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 561276007086 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 561276007090 EDD domain protein, DegV family; Region: DegV; TIGR00762 561276007091 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 561276007093 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4835 561276007095 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 561276007096 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 561276007097 active site 561276007098 substrate binding site [chemical binding]; other site 561276007099 metal binding site [ion binding]; metal-binding site 561276007105 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 561276007106 YbbR-like protein; Region: YbbR; pfam07949 561276007109 1 transmembrane helix predicted for SPN23F15260 by TMHMM2.0 at aa 5-27 561276007111 Uncharacterized conserved protein [Function unknown]; Region: COG1624 561276007112 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 561276007114 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 561276007115 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 561276007116 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 561276007120 Prophage MM1 561276007121 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 561276007122 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 561276007123 amidase catalytic site [active] 561276007124 Zn binding residues [ion binding]; other site 561276007125 substrate binding site [chemical binding]; other site 561276007132 Phage holin protein (Holin_LLH); Region: Holin_LLH; pfam09682 561276007133 1 transmembrane helix predicted for SPN23F15300 by TMHMM2.0 at aa 7-24 561276007134 toxin secretion/phage lysis holin; Region: holin_tox_secr; TIGR01593 561276007136 Siphovirus protein of unknown function (DUF859); Region: DUF859; pfam05895 561276007137 Siphovirus protein of unknown function (DUF859); Region: DUF859; pfam05895 561276007143 putative phage tail component, N-terminal domain; Region: phi3626_gp14_N; TIGR01633 561276007144 Phage tail protein; Region: Sipho_tail; cl17486 561276007146 tape measure domain; Region: tape_meas_nterm; TIGR02675 561276007147 Bacteriophage Gp15 protein; Region: Phage_Gp15; pfam06854 561276007149 Minor capsid protein from bacteriophage; Region: Minor_capsid_3; pfam12691 561276007150 Minor capsid protein; Region: Minor_capsid_2; pfam11114 561276007151 Minor capsid protein; Region: Minor_capsid_1; pfam10665 561276007152 Phage minor structural protein GP20; Region: Phage_GP20; pfam06810 561276007154 Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152 561276007156 phage portal protein, putative, A118 family; Region: A118_put_portal; TIGR01542 561276007157 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 561276007159 Phage terminase large subunit; Region: Terminase_3; cl12054 561276007160 Terminase-like family; Region: Terminase_6; pfam03237 561276007163 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 561276007164 ParB-like nuclease domain; Region: ParBc; pfam02195 561276007165 Domain of unknown function (DUF4417); Region: DUF4417; pfam14386 561276007167 Protein of unknwon function (DUF3310); Region: DUF3310; pfam11753 561276007168 1 transmembrane helix predicted for SPN23F15550 by TMHMM2.0 at aa 24-46 561276007169 YopX protein; Region: YopX; cl09859 561276007170 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 561276007172 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 561276007173 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 561276007175 1 transmembrane helix predicted for SPN23F15660 by TMHMM2.0 at aa 4-26 561276007176 C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145 561276007177 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 561276007178 cofactor binding site; other site 561276007179 DNA binding site [nucleotide binding] 561276007180 substrate interaction site [chemical binding]; other site 561276007181 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 561276007185 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 561276007186 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 561276007187 dimer interface [polypeptide binding]; other site 561276007188 ssDNA binding site [nucleotide binding]; other site 561276007189 tetramer (dimer of dimers) interface [polypeptide binding]; other site 561276007191 Protein of unknown function (DUF1351); Region: DUF1351; pfam07083 561276007193 ERF superfamily; Region: ERF; pfam04404 561276007196 Helix-turn-helix domain; Region: HTH_36; pfam13730 561276007197 phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111 561276007198 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 561276007199 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 561276007200 non-specific DNA binding site [nucleotide binding]; other site 561276007201 salt bridge; other site 561276007202 sequence-specific DNA binding site [nucleotide binding]; other site 561276007204 Domain of unknown function (DUF955); Region: DUF955; pfam06114 561276007206 2 transmembrane helices predicted for SPN23F15790 by TMHMM2.0 at aa 4-21 and 74-96 561276007207 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 561276007208 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 561276007209 Int/Topo IB signature motif; other site 561276007211 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 561276007212 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 561276007215 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 561276007216 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 561276007217 dimer interface [polypeptide binding]; other site 561276007218 phosphate binding site [ion binding]; other site 561276007221 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 561276007224 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 561276007225 homotrimer interaction site [polypeptide binding]; other site 561276007226 putative active site [active] 561276007229 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 561276007230 G1 box; other site 561276007231 GTP/Mg2+ binding site [chemical binding]; other site 561276007232 Switch I region; other site 561276007233 G2 box; other site 561276007234 G3 box; other site 561276007235 Switch II region; other site 561276007236 G4 box; other site 561276007237 G5 box; other site 561276007240 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 561276007241 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 561276007242 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 561276007243 Walker A motif; other site 561276007244 ATP binding site [chemical binding]; other site 561276007245 Walker B motif; other site 561276007246 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 561276007250 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 561276007251 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 561276007252 folate binding site [chemical binding]; other site 561276007253 NADP+ binding site [chemical binding]; other site 561276007256 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 561276007257 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 561276007258 dimerization interface [polypeptide binding]; other site 561276007259 DPS ferroxidase diiron center [ion binding]; other site 561276007260 ion pore; other site 561276007262 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 561276007263 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 561276007264 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 561276007265 active site 561276007270 triosephosphate isomerase; Provisional; Region: PRK14567 561276007271 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 561276007272 substrate binding site [chemical binding]; other site 561276007273 dimer interface [polypeptide binding]; other site 561276007274 catalytic triad [active] 561276007277 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 561276007278 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 561276007280 Homoserine trans-succinylase [Amino acid transport and metabolism]; Region: MetA; COG1897 561276007281 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 561276007282 proposed active site lysine [active] 561276007283 conserved cys residue [active] 561276007285 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 561276007286 active site 561276007289 Methyltransferase domain; Region: Methyltransf_31; pfam13847 561276007290 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 561276007291 S-adenosylmethionine binding site [chemical binding]; other site 561276007293 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 561276007294 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 561276007295 Walker A/P-loop; other site 561276007296 ATP binding site [chemical binding]; other site 561276007297 Q-loop/lid; other site 561276007298 ABC transporter signature motif; other site 561276007299 Walker B; other site 561276007300 D-loop; other site 561276007301 H-loop/switch region; other site 561276007302 TOBE domain; Region: TOBE_2; pfam08402 561276007307 Isochorismatase family; Region: Isochorismatase; pfam00857 561276007308 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 561276007309 catalytic triad [active] 561276007310 conserved cis-peptide bond; other site 561276007312 Pleiotropic transcriptional repressor [Transcription]; Region: CodY; COG4465 561276007313 CodY GAF-like domain; Region: CodY; pfam06018 561276007314 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 561276007315 putative DNA binding site [nucleotide binding]; other site 561276007316 putative Zn2+ binding site [ion binding]; other site 561276007319 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 561276007320 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 561276007321 ATP binding site [chemical binding]; other site 561276007322 Mg++ binding site [ion binding]; other site 561276007323 motif III; other site 561276007324 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 561276007325 nucleotide binding region [chemical binding]; other site 561276007326 ATP-binding site [chemical binding]; other site 561276007331 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 561276007332 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 561276007333 putative substrate translocation pore; other site 561276007335 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 561276007336 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 561276007337 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 561276007338 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 561276007344 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 561276007345 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 561276007346 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 561276007349 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 561276007350 catalytic triad [active] 561276007352 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 561276007353 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 561276007354 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 561276007355 active site 561276007359 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 561276007360 1 transmembrane helix predicted for SPN23F16070 by TMHMM2.0 at aa 4-26 561276007362 putative transposase OrfB; Reviewed; Region: PHA02517 561276007363 HTH-like domain; Region: HTH_21; pfam13276 561276007364 Integrase core domain; Region: rve; pfam00665 561276007365 Integrase core domain; Region: rve_2; pfam13333 561276007367 IS3-Spn1 orf A (pseudogene) 561276007368 Predicted membrane protein [Function unknown]; Region: COG4720 561276007369 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 561276007370 dimer interface [polypeptide binding]; other site 561276007371 substrate binding site [chemical binding]; other site 561276007372 ATP binding site [chemical binding]; other site 561276007374 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 561276007375 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 561276007376 dimerization interface 3.5A [polypeptide binding]; other site 561276007377 active site 561276007380 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 561276007381 Major Facilitator Superfamily; Region: MFS_1; pfam07690 561276007382 putative substrate translocation pore; other site 561276007385 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 561276007386 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 561276007387 PhnA protein; Region: PhnA; pfam03831 561276007390 cytidylate kinase; Provisional; Region: cmk; PRK00023 561276007391 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 561276007392 CMP-binding site; other site 561276007393 The sites determining sugar specificity; other site 561276007396 1 transmembrane helix predicted for SPN23F16180 by TMHMM2.0 at aa 35-57 561276007398 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 561276007399 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 561276007400 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 561276007401 Ligand binding site; other site 561276007402 Putative Catalytic site; other site 561276007403 DXD motif; other site 561276007405 UDP-glucose 4-epimerase; Region: PLN02240 561276007406 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 561276007407 NAD binding site [chemical binding]; other site 561276007408 homodimer interface [polypeptide binding]; other site 561276007409 active site 561276007410 substrate binding site [chemical binding]; other site 561276007412 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 561276007414 Uncharacterized conserved protein [Function unknown]; Region: COG0327 561276007415 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 561276007417 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 561276007418 Family of unknown function (DUF633); Region: DUF633; pfam04816 561276007420 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 561276007421 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 561276007422 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 561276007423 motif II; other site 561276007427 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 561276007428 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 561276007429 putative acyl-acceptor binding pocket; other site 561276007431 1 transmembrane helix predicted for SPN23F16270 by TMHMM2.0 at aa 217-239 561276007432 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 561276007433 Cadmium resistance transporter; Region: Cad; pfam03596 561276007435 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 561276007436 16S/18S rRNA binding site [nucleotide binding]; other site 561276007437 S13e-L30e interaction site [polypeptide binding]; other site 561276007438 25S rRNA binding site [nucleotide binding]; other site 561276007440 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 561276007441 NADH(P)-binding; Region: NAD_binding_10; pfam13460 561276007442 NAD binding site [chemical binding]; other site 561276007443 substrate binding site [chemical binding]; other site 561276007444 putative active site [active] 561276007446 2 transmembrane helices predicted for SPN23F16310 by TMHMM2.0 at aa 7-29 and 39-58 561276007447 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 561276007448 metal binding site [ion binding]; metal-binding site 561276007449 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 561276007450 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 561276007451 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 561276007452 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 561276007453 active site 561276007454 dimer interface [polypeptide binding]; other site 561276007455 motif 1; other site 561276007456 motif 2; other site 561276007457 motif 3; other site 561276007458 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 561276007459 anticodon binding site; other site 561276007464 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 561276007465 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 561276007466 ATP binding site [chemical binding]; other site 561276007467 Mg2+ binding site [ion binding]; other site 561276007468 G-X-G motif; other site 561276007470 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 561276007471 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 561276007472 active site 561276007473 phosphorylation site [posttranslational modification] 561276007474 intermolecular recognition site; other site 561276007475 dimerization interface [polypeptide binding]; other site 561276007476 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 561276007477 DNA binding site [nucleotide binding] 561276007480 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 561276007481 nucleophilic elbow; other site 561276007482 catalytic triad; other site 561276007483 Predicted transcriptional regulator [Transcription]; Region: COG1959 561276007484 Transcriptional regulator; Region: Rrf2; pfam02082 561276007487 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 561276007488 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 561276007489 active site 561276007490 metal binding site [ion binding]; metal-binding site 561276007492 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 561276007493 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 561276007494 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 561276007495 FeoA domain; Region: FeoA; pfam04023 561276007499 6 transmembrane helices predicted for SPN23F16410 by TMHMM2.0 at aa 20-42, 55-74, 78-94, 115-134,144-166 and 187-209 561276007500 3 transmembrane helices predicted for SPN23F16420 by TMHMM2.0 at aa 7-26, 31-53 and 73-92 561276007501 Start and end of CDS inferred from Fasta hits; membrane protein (pseudogene) 561276007502 2 transmembrane helices predicted for SPN23F16430 by TMHMM2.0 at aa 4-26 and 33-52 561276007503 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 561276007504 putative active site [active] 561276007505 dimerization interface [polypeptide binding]; other site 561276007506 putative tRNAtyr binding site [nucleotide binding]; other site 561276007508 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 561276007509 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 561276007510 Zn2+ binding site [ion binding]; other site 561276007511 Mg2+ binding site [ion binding]; other site 561276007512 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 561276007513 synthetase active site [active] 561276007514 NTP binding site [chemical binding]; other site 561276007515 metal binding site [ion binding]; metal-binding site 561276007516 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 561276007517 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 561276007521 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 561276007523 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 561276007524 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 561276007525 active site 561276007526 Zn binding site [ion binding]; other site 561276007530 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 561276007531 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 561276007535 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 561276007536 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 561276007537 ABC-ATPase subunit interface; other site 561276007538 dimer interface [polypeptide binding]; other site 561276007539 putative PBP binding regions; other site 561276007541 8 transmembrane helices predicted for SPN23F16510 by TMHMM2.0 at aa 19-41, 61-83, 95-114,136-154, 174-193, 197-216, 223-242 and 246-268 561276007542 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 561276007543 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 561276007544 metal binding site [ion binding]; metal-binding site 561276007547 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 561276007548 dimer interface [polypeptide binding]; other site 561276007549 catalytic triad [active] 561276007550 peroxidatic and resolving cysteines [active] 561276007553 FtsX-like permease family; Region: FtsX; pfam02687 561276007554 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 561276007555 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 561276007556 FtsX-like permease family; Region: FtsX; pfam02687 561276007559 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 561276007560 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 561276007561 Walker A/P-loop; other site 561276007562 ATP binding site [chemical binding]; other site 561276007563 Q-loop/lid; other site 561276007564 ABC transporter signature motif; other site 561276007565 Walker B; other site 561276007566 D-loop; other site 561276007567 H-loop/switch region; other site 561276007572 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 561276007573 catalytic core [active] 561276007574 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 561276007576 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 561276007577 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 561276007578 active site 561276007579 HIGH motif; other site 561276007580 nucleotide binding site [chemical binding]; other site 561276007581 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 561276007582 active site 561276007583 KMSKS motif; other site 561276007584 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 561276007585 tRNA binding surface [nucleotide binding]; other site 561276007586 anticodon binding site; other site 561276007587 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 561276007592 DivIVA domain; Region: DivI1A_domain; TIGR03544 561276007593 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 561276007594 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 561276007596 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 561276007597 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 561276007598 RNA binding surface [nucleotide binding]; other site 561276007600 YGGT family; Region: YGGT; pfam02325 561276007602 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 561276007604 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 561276007605 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 561276007606 catalytic residue [active] 561276007608 cell division protein FtsZ; Validated; Region: PRK09330 561276007609 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 561276007610 nucleotide binding site [chemical binding]; other site 561276007611 SulA interaction site; other site 561276007615 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 561276007616 Cell division protein FtsA; Region: FtsA; smart00842 561276007617 Cell division protein FtsA; Region: FtsA; pfam14450 561276007618 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 561276007621 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 561276007623 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 561276007624 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 561276007625 nudix motif; other site 561276007627 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 561276007628 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 561276007629 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 561276007630 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 561276007634 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 561276007635 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 561276007636 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 561276007641 recombination protein RecR; Reviewed; Region: recR; PRK00076 561276007642 RecR protein; Region: RecR; pfam02132 561276007643 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 561276007644 putative active site [active] 561276007645 putative metal-binding site [ion binding]; other site 561276007646 tetramer interface [polypeptide binding]; other site 561276007650 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 561276007651 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 561276007652 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 561276007653 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 561276007656 1 transmembrane helix predicted for SPN23F16740 by TMHMM2.0 at aa 13-32 561276007657 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 561276007658 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 561276007659 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 561276007660 putative active site [active] 561276007663 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 561276007664 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 561276007665 nucleotide binding site [chemical binding]; other site 561276007667 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 561276007668 Class I aldolases; Region: Aldolase_Class_I; cl17187 561276007669 catalytic residue [active] 561276007671 Protein of unknown function, DUF624; Region: DUF624; pfam04854 561276007674 Domain of unknown function (DUF386); Region: DUF386; pfam04074 561276007676 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 561276007677 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 561276007678 dimer interface [polypeptide binding]; other site 561276007679 conserved gate region; other site 561276007680 putative PBP binding loops; other site 561276007681 ABC-ATPase subunit interface; other site 561276007683 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 561276007684 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 561276007685 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 561276007686 putative PBP binding loops; other site 561276007687 dimer interface [polypeptide binding]; other site 561276007688 ABC-ATPase subunit interface; other site 561276007690 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 561276007691 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 561276007695 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 561276007696 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 561276007697 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 561276007698 active site turn [active] 561276007699 phosphorylation site [posttranslational modification] 561276007702 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 561276007703 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 561276007704 putative active site cavity [active] 561276007706 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 561276007707 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 561276007708 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 561276007711 Neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: NanH; COG4409 561276007712 Sialidase, N-terminal domain; Region: Sialidase; pfam02973 561276007713 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 561276007714 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 561276007715 Asp-box motif; other site 561276007716 catalytic site [active] 561276007722 1 transmembrane helix predicted for SPN23F16870 by TMHMM2.0 at aa 5-27 561276007723 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 561276007724 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 561276007725 dimer interface [polypeptide binding]; other site 561276007726 conserved gate region; other site 561276007727 putative PBP binding loops; other site 561276007728 ABC-ATPase subunit interface; other site 561276007731 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 561276007732 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 561276007733 dimer interface [polypeptide binding]; other site 561276007734 conserved gate region; other site 561276007735 putative PBP binding loops; other site 561276007736 ABC-ATPase subunit interface; other site 561276007739 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 561276007740 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 561276007742 1 transmembrane helix predicted for SPN23F16900 by TMHMM2.0 at aa 7-24 561276007744 uncharacterized protein, YhcH/YjgK/YiaL family; Region: TIGR00022 561276007746 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 561276007747 Sialidase, N-terminal domain; Region: Sialidase; pfam02973 561276007748 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 561276007749 catalytic site [active] 561276007750 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 561276007751 Asp-box motif; other site 561276007752 Asp-box motif; other site 561276007753 catalytic site [active] 561276007759 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 561276007761 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 561276007762 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 561276007763 ssDNA binding site; other site 561276007764 generic binding surface II; other site 561276007765 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 561276007766 ATP binding site [chemical binding]; other site 561276007767 putative Mg++ binding site [ion binding]; other site 561276007768 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 561276007769 nucleotide binding region [chemical binding]; other site 561276007770 ATP-binding site [chemical binding]; other site 561276007775 alanine racemase; Reviewed; Region: alr; PRK00053 561276007776 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 561276007777 active site 561276007778 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 561276007779 dimer interface [polypeptide binding]; other site 561276007780 substrate binding site [chemical binding]; other site 561276007781 catalytic residues [active] 561276007785 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 561276007787 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG0722 561276007788 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 561276007790 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG0722 561276007791 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 561276007793 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 561276007794 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 561276007795 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 561276007796 nucleotide binding region [chemical binding]; other site 561276007797 ATP-binding site [chemical binding]; other site 561276007798 SEC-C motif; Region: SEC-C; pfam02810 561276007806 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 561276007807 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 561276007808 Walker A/P-loop; other site 561276007809 ATP binding site [chemical binding]; other site 561276007810 Q-loop/lid; other site 561276007811 ABC transporter signature motif; other site 561276007812 Walker B; other site 561276007813 D-loop; other site 561276007814 H-loop/switch region; other site 561276007817 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 561276007818 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 561276007819 non-specific DNA binding site [nucleotide binding]; other site 561276007820 salt bridge; other site 561276007821 sequence-specific DNA binding site [nucleotide binding]; other site 561276007822 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 561276007824 GTP-binding protein Der; Reviewed; Region: PRK00093 561276007825 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 561276007826 G1 box; other site 561276007827 GTP/Mg2+ binding site [chemical binding]; other site 561276007828 Switch I region; other site 561276007829 G2 box; other site 561276007830 Switch II region; other site 561276007831 G3 box; other site 561276007832 G4 box; other site 561276007833 G5 box; other site 561276007834 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 561276007835 G1 box; other site 561276007836 GTP/Mg2+ binding site [chemical binding]; other site 561276007837 Switch I region; other site 561276007838 G2 box; other site 561276007839 G3 box; other site 561276007840 Switch II region; other site 561276007841 G4 box; other site 561276007842 G5 box; other site 561276007847 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 561276007848 dimer interface [polypeptide binding]; other site 561276007849 FMN binding site [chemical binding]; other site 561276007850 NADPH bind site [chemical binding]; other site 561276007852 primosomal protein DnaI; Reviewed; Region: PRK08939 561276007853 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 561276007854 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 561276007855 Walker A motif; other site 561276007856 ATP binding site [chemical binding]; other site 561276007857 Walker B motif; other site 561276007860 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 561276007862 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 561276007863 ATP cone domain; Region: ATP-cone; pfam03477 561276007865 Predicted transcriptional regulators [Transcription]; Region: COG1725 561276007866 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 561276007867 DNA-binding site [nucleotide binding]; DNA binding site 561276007869 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 561276007870 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 561276007871 Walker A/P-loop; other site 561276007872 ATP binding site [chemical binding]; other site 561276007873 Q-loop/lid; other site 561276007874 ABC transporter signature motif; other site 561276007875 Walker B; other site 561276007876 D-loop; other site 561276007877 H-loop/switch region; other site 561276007880 6 transmembrane helices predicted for SPN23F17170 by TMHMM2.0 at aa 13-35, 50-72, 108-130,150-172, 184-206 and 226-248 561276007881 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 561276007882 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 561276007883 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 561276007884 Walker A/P-loop; other site 561276007885 ATP binding site [chemical binding]; other site 561276007886 Q-loop/lid; other site 561276007887 ABC transporter signature motif; other site 561276007888 Walker B; other site 561276007889 D-loop; other site 561276007890 H-loop/switch region; other site 561276007891 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 561276007895 Uncharacterized conserved protein [Function unknown]; Region: COG0398 561276007896 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 561276007897 5 transmembrane helices predicted for SPN23F17210 by TMHMM2.0 at aa 20-42, 67-89, 96-118, 146-168 and 175-197 561276007900 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 561276007901 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 561276007902 nucleotide binding site [chemical binding]; other site 561276007905 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 561276007906 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 561276007907 active site turn [active] 561276007908 phosphorylation site [posttranslational modification] 561276007909 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 561276007910 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 561276007911 HPr interaction site; other site 561276007912 glycerol kinase (GK) interaction site [polypeptide binding]; other site 561276007913 active site 561276007914 phosphorylation site [posttranslational modification] 561276007920 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 561276007921 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 561276007922 substrate binding [chemical binding]; other site 561276007923 active site 561276007924 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 561276007928 Transcriptional regulators [Transcription]; Region: PurR; COG1609 561276007929 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 561276007930 DNA binding site [nucleotide binding] 561276007931 domain linker motif; other site 561276007932 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 561276007933 dimerization interface [polypeptide binding]; other site 561276007934 ligand binding site [chemical binding]; other site 561276007935 sodium binding site [ion binding]; other site 561276007939 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 561276007940 homodimer interface [polypeptide binding]; other site 561276007941 catalytic residues [active] 561276007942 NAD binding site [chemical binding]; other site 561276007943 substrate binding pocket [chemical binding]; other site 561276007944 flexible flap; other site 561276007946 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 561276007947 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 561276007948 dimer interface [polypeptide binding]; other site 561276007949 active site 561276007952 IS1381 transposase OrfA (pseudogene) 561276007954 Uncharacterized conserved protein [Function unknown]; Region: COG3610 561276007956 Uncharacterized conserved protein [Function unknown]; Region: COG2966 561276007957 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 561276007959 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 561276007960 Catalytic domain of Protein Kinases; Region: PKc; cd00180 561276007961 active site 561276007962 ATP binding site [chemical binding]; other site 561276007963 substrate binding site [chemical binding]; other site 561276007964 activation loop (A-loop); other site 561276007965 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 561276007966 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 561276007967 PASTA domain; Region: PASTA; smart00740 561276007968 PASTA domain; Region: PASTA; smart00740 561276007969 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 561276007974 1 transmembrane helix predicted for SPN23F17350 by TMHMM2.0 at aa 345-364 561276007978 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 561276007979 active site 561276007981 16S rRNA methyltransferase B; Provisional; Region: PRK14902 561276007982 NusB family; Region: NusB; pfam01029 561276007983 putative RNA binding site [nucleotide binding]; other site 561276007984 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 561276007985 S-adenosylmethionine binding site [chemical binding]; other site 561276007989 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 561276007990 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 561276007991 putative active site [active] 561276007992 substrate binding site [chemical binding]; other site 561276007993 putative cosubstrate binding site; other site 561276007994 catalytic site [active] 561276007995 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 561276007996 substrate binding site [chemical binding]; other site 561276007999 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 561276008000 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 561276008001 ATP binding site [chemical binding]; other site 561276008002 putative Mg++ binding site [ion binding]; other site 561276008003 helicase superfamily c-terminal domain; Region: HELICc; smart00490 561276008004 ATP-binding site [chemical binding]; other site 561276008009 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 561276008011 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 561276008012 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 561276008013 catalytic site [active] 561276008014 G-X2-G-X-G-K; other site 561276008016 hypothetical protein; Provisional; Region: PRK00106 561276008017 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 561276008018 Zn2+ binding site [ion binding]; other site 561276008019 Mg2+ binding site [ion binding]; other site 561276008022 1 transmembrane helix predicted for SPN23F17420 by TMHMM2.0 at aa 5-24 561276008023 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 561276008024 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 561276008025 catalytic residues [active] 561276008027 1 transmembrane helix predicted for SPN23F17450 by TMHMM2.0 at aa 13-35 561276008028 KilA-N domain; Region: KilA-N; pfam04383 561276008029 IS1167 transposase (pseudogene) 561276008031 hypothetical protein; Provisional; Region: PRK13670 561276008032 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 561276008034 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 561276008035 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 561276008036 S-adenosylmethionine binding site [chemical binding]; other site 561276008038 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 561276008040 Isochorismatase family; Region: Isochorismatase; pfam00857 561276008041 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 561276008042 catalytic triad [active] 561276008043 conserved cis-peptide bond; other site 561276008045 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 561276008046 Zn2+ binding site [ion binding]; other site 561276008047 Mg2+ binding site [ion binding]; other site 561276008049 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 561276008050 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 561276008051 active site 561276008052 (T/H)XGH motif; other site 561276008054 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 561276008056 GTPase YqeH; Provisional; Region: PRK13796 561276008057 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 561276008058 GTP/Mg2+ binding site [chemical binding]; other site 561276008059 G4 box; other site 561276008060 G5 box; other site 561276008061 G1 box; other site 561276008062 Switch I region; other site 561276008063 G2 box; other site 561276008064 G3 box; other site 561276008065 Switch II region; other site 561276008068 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 561276008069 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 561276008070 active site 561276008071 motif I; other site 561276008072 motif II; other site 561276008075 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 561276008076 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 561276008077 Cl binding site [ion binding]; other site 561276008078 oligomer interface [polypeptide binding]; other site 561276008080 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 561276008081 Mechanosensitive ion channel; Region: MS_channel; pfam00924 561276008083 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 561276008085 1 transmembrane helix predicted for SPN23F17600 by TMHMM2.0 at aa 15-37 561276008086 serine/threonine transporter SstT; Provisional; Region: PRK14695 561276008087 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 561276008089 7 transmembrane helices predicted for SPN23F17610 by TMHMM2.0 at aa 2-24, 53-75, 96-113, 128-150,210-232, 242-264 and 269-291 561276008090 Predicted membrane protein [Function unknown]; Region: COG4129 561276008091 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 561276008092 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 561276008094 3 transmembrane helices predicted for SPN23F17620 by TMHMM2.0 at aa 10-41, 54-76 and 119-141 561276008095 Island encoding a large cell wall anchored glycoprotein 561276008096 1 transmembrane helix predicted for SPN23F17650 by TMHMM2.0 at aa 38-57 561276008097 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 561276008098 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 561276008099 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 561276008100 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 561276008103 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 561276008104 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 561276008108 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 561276008109 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 561276008110 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 561276008111 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 561276008112 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 561276008113 Adenylate cyclase associated (CAP) N terminal; Region: CAP_N; pfam01213 561276008114 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417 561276008115 SecY translocase; Region: SecY; pfam00344 561276008117 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 561276008118 active site 561276008120 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 561276008121 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 561276008122 Ligand binding site; other site 561276008123 metal-binding site 561276008125 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 561276008126 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 561276008127 Ligand binding site; other site 561276008128 metal-binding site 561276008130 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 561276008131 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 561276008132 active site 561276008134 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 561276008135 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 561276008136 Ligand binding site; other site 561276008137 metal-binding site 561276008138 glycosyltransferase, SP_1767 family; Region: glyco_access_1; TIGR03728 561276008141 beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814 561276008142 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 561276008143 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 561276008144 Ligand binding site; other site 561276008145 metal-binding site 561276008147 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 561276008148 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 561276008149 active site 561276008150 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 561276008151 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 561276008152 Ligand binding site; other site 561276008153 metal-binding site 561276008156 serine-rich repeat adhesion glycoprotein AST domain; Region: ser_adhes_Nterm; TIGR04224 561276008157 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 561276008159 1 transmembrane helix predicted for SPN23F17820 by TMHMM2.0 at aa 10-28 561276008160 DDE superfamily endonuclease; Region: DDE_3; pfam13358 561276008161 MarR family; Region: MarR; pfam01047 561276008162 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 561276008163 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 561276008164 catalytic residues [active] 561276008166 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 561276008168 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 561276008169 amphipathic channel; other site 561276008170 Asn-Pro-Ala signature motifs; other site 561276008172 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 561276008173 oligoendopeptidase F; Region: pepF; TIGR00181 561276008174 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 561276008175 Zn binding site [ion binding]; other site 561276008179 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 561276008180 RNA methyltransferase, RsmE family; Region: TIGR00046 561276008182 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 561276008183 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 561276008184 S-adenosylmethionine binding site [chemical binding]; other site 561276008186 Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253 561276008187 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 561276008188 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 561276008189 active site 561276008190 catalytic triad [active] 561276008191 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 561276008192 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 561276008193 Walker A motif; other site 561276008194 ATP binding site [chemical binding]; other site 561276008195 Walker B motif; other site 561276008196 arginine finger; other site 561276008199 Peptidase family M50; Region: Peptidase_M50; pfam02163 561276008201 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 561276008202 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 561276008205 recombination factor protein RarA; Reviewed; Region: PRK13342 561276008206 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 561276008207 Walker A motif; other site 561276008208 ATP binding site [chemical binding]; other site 561276008209 Walker B motif; other site 561276008210 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 561276008211 arginine finger; other site 561276008212 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 561276008215 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 561276008216 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 561276008217 substrate binding [chemical binding]; other site 561276008218 active site 561276008219 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 561276008221 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 561276008225 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 561276008226 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 561276008227 dimer interface [polypeptide binding]; other site 561276008228 conserved gate region; other site 561276008229 ABC-ATPase subunit interface; other site 561276008232 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 561276008233 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 561276008234 dimer interface [polypeptide binding]; other site 561276008235 conserved gate region; other site 561276008236 ABC-ATPase subunit interface; other site 561276008239 Transcriptional regulators [Transcription]; Region: PurR; COG1609 561276008240 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 561276008241 DNA binding site [nucleotide binding] 561276008242 domain linker motif; other site 561276008243 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 561276008244 dimerization interface [polypeptide binding]; other site 561276008245 ligand binding site [chemical binding]; other site 561276008246 sodium binding site [ion binding]; other site 561276008250 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 561276008251 Mga helix-turn-helix domain; Region: Mga; pfam05043 561276008252 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 561276008257 Predicted membrane protein [Function unknown]; Region: COG2261 561276008258 2 transmembrane helices predicted for SPN23F18120 by TMHMM2.0 at aa 2-24 and 28-50 561276008260 2 transmembrane helices predicted for SPN23F18130 by TMHMM2.0 at aa 7-25 and 53-75 561276008261 Small integral membrane protein [Function unknown]; Region: COG5547 561276008262 2 transmembrane helices predicted for SPN23F18140 by TMHMM2.0 at aa 7-29 and 33-50 561276008263 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 561276008265 CsbD-like protein 561276008267 transposase (pseudogene) 561276008268 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 561276008270 Uncharacterized conserved protein [Function unknown]; Region: COG1262 561276008271 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 561276008273 arylsulfatase; Provisional; Region: PRK13759 561276008274 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 561276008277 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 561276008278 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 561276008280 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 561276008281 active site 561276008282 methionine cluster; other site 561276008283 phosphorylation site [posttranslational modification] 561276008284 metal binding site [ion binding]; metal-binding site 561276008286 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 561276008287 active site 561276008288 P-loop; other site 561276008289 phosphorylation site [posttranslational modification] 561276008291 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cl04270 561276008292 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 561276008294 MarR family; Region: MarR_2; pfam12802 561276008295 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 561276008296 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 561276008299 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 561276008300 Coenzyme A binding pocket [chemical binding]; other site 561276008302 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 561276008303 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 561276008304 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 561276008305 5 transmembrane helices predicted for SPN23F18280 by TMHMM2.0 at aa 4-21, 68-90, 125-147, 159-181 and 196-218 561276008308 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 561276008309 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 561276008310 non-specific DNA binding site [nucleotide binding]; other site 561276008311 salt bridge; other site 561276008312 sequence-specific DNA binding site [nucleotide binding]; other site 561276008313 Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856 561276008316 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 561276008317 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 561276008318 substrate binding site [chemical binding]; other site 561276008319 active site 561276008320 catalytic residues [active] 561276008321 heterodimer interface [polypeptide binding]; other site 561276008324 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 561276008325 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 561276008326 pyridoxal 5'-phosphate binding site [chemical binding]; other site 561276008327 catalytic residue [active] 561276008330 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 561276008331 active site 561276008333 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 561276008334 active site 561276008335 ribulose/triose binding site [chemical binding]; other site 561276008336 phosphate binding site [ion binding]; other site 561276008337 substrate (anthranilate) binding pocket [chemical binding]; other site 561276008338 product (indole) binding pocket [chemical binding]; other site 561276008341 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 561276008342 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 561276008343 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 561276008346 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 561276008347 Glutamine amidotransferase class-I; Region: GATase; pfam00117 561276008348 glutamine binding [chemical binding]; other site 561276008349 catalytic triad [active] 561276008352 anthranilate synthase component I; Provisional; Region: PRK13570 561276008353 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 561276008354 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 561276008357 Transcriptional regulators [Transcription]; Region: PurR; COG1609 561276008358 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 561276008359 DNA binding site [nucleotide binding] 561276008360 domain linker motif; other site 561276008361 Ligand-binding domain of a transcription repressor, FucR, which functions as a molecular sensor of L-fucose availability; Region: PBP1_FucR_like; cd06276 561276008362 putative dimerization interface [polypeptide binding]; other site 561276008363 putative ligand binding site [chemical binding]; other site 561276008366 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 561276008367 MgtC family; Region: MgtC; pfam02308 561276008369 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 561276008370 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 561276008371 dimer interface [polypeptide binding]; other site 561276008372 conserved gate region; other site 561276008373 putative PBP binding loops; other site 561276008374 ABC-ATPase subunit interface; other site 561276008375 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 561276008376 putative PBP binding loops; other site 561276008377 dimer interface [polypeptide binding]; other site 561276008378 ABC-ATPase subunit interface; other site 561276008382 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 561276008383 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 561276008384 Walker A/P-loop; other site 561276008385 ATP binding site [chemical binding]; other site 561276008386 Q-loop/lid; other site 561276008387 ABC transporter signature motif; other site 561276008388 Walker B; other site 561276008389 D-loop; other site 561276008390 H-loop/switch region; other site 561276008391 TOBE domain; Region: TOBE; pfam03459 561276008396 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 561276008397 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 561276008399 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5255 561276008400 Domain of unknown function (DUF1868); Region: 2H-phosphodiest; pfam08975 561276008402 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 561276008403 UDP-glucose 4-epimerase; Region: PLN02240 561276008404 NAD binding site [chemical binding]; other site 561276008405 homodimer interface [polypeptide binding]; other site 561276008406 active site 561276008407 substrate binding site [chemical binding]; other site 561276008409 Galactose-1-phosphate uridyltransferase [Carbohydrate transport and metabolism]; Region: GalT; COG4468 561276008410 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 561276008411 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 561276008414 Phosphate uptake regulator [Inorganic ion transport and metabolism]; Region: PhoU; COG0704 561276008415 PhoU domain; Region: PhoU; pfam01895 561276008417 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 561276008418 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 561276008419 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 561276008420 Pectate lyase; Region: Pec_lyase_C; cl01593 561276008423 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 561276008424 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 561276008425 inhibitor-cofactor binding pocket; inhibition site 561276008426 pyridoxal 5'-phosphate binding site [chemical binding]; other site 561276008427 catalytic residue [active] 561276008429 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 561276008431 1 transmembrane helix predicted for SPN23F18540 by TMHMM2.0 at aa 36-58 561276008432 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 561276008433 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 561276008434 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 561276008435 Walker A/P-loop; other site 561276008436 ATP binding site [chemical binding]; other site 561276008437 Q-loop/lid; other site 561276008438 ABC transporter signature motif; other site 561276008439 Walker B; other site 561276008440 D-loop; other site 561276008441 H-loop/switch region; other site 561276008445 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 561276008446 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 561276008447 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 561276008448 Walker A/P-loop; other site 561276008449 ATP binding site [chemical binding]; other site 561276008450 Q-loop/lid; other site 561276008451 ABC transporter signature motif; other site 561276008452 Walker B; other site 561276008453 D-loop; other site 561276008454 H-loop/switch region; other site 561276008459 Predicted membrane protein [Function unknown]; Region: COG2323 561276008461 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 561276008462 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 561276008463 1 transmembrane helix predicted for SPN23F18590 by TMHMM2.0 at aa 13-35 561276008464 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 561276008465 active site 561276008466 putative catalytic site [active] 561276008467 DNA binding site [nucleotide binding] 561276008468 putative phosphate binding site [ion binding]; other site 561276008469 metal binding site A [ion binding]; metal-binding site 561276008470 AP binding site [nucleotide binding]; other site 561276008471 metal binding site B [ion binding]; metal-binding site 561276008476 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 561276008477 active site 561276008478 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 561276008479 active site 561276008481 xanthine permease; Region: pbuX; TIGR03173 561276008482 Sulfate transporter family; Region: Sulfate_transp; pfam00916 561276008484 12 transmembrane helices predicted for SPN23F18630 by TMHMM2.0 at aa 12-34, 38-60, 67-89, 93-115,122-144, 159-176, 183-202, 230-252, 273-290, 305-327,334-356 and 393-415 561276008486 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 561276008487 putative active site [active] 561276008488 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 561276008489 putative active site [active] 561276008491 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 561276008492 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 561276008493 cofactor binding site; other site 561276008494 DNA binding site [nucleotide binding] 561276008495 substrate interaction site [chemical binding]; other site 561276008496 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 561276008501 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 561276008502 CoenzymeA binding site [chemical binding]; other site 561276008503 subunit interaction site [polypeptide binding]; other site 561276008504 PHB binding site; other site 561276008506 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 561276008507 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 561276008508 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 561276008511 galactokinase; Provisional; Region: PRK05322 561276008512 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 561276008513 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 561276008514 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 561276008520 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 561276008521 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 561276008522 DNA binding site [nucleotide binding] 561276008523 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 561276008524 putative dimerization interface [polypeptide binding]; other site 561276008525 putative ligand binding site [chemical binding]; other site 561276008529 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 561276008530 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 561276008531 catalytic Zn binding site [ion binding]; other site 561276008532 NAD(P) binding site [chemical binding]; other site 561276008533 structural Zn binding site [ion binding]; other site 561276008537 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 561276008538 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 561276008539 DNA binding residues [nucleotide binding] 561276008540 putative dimer interface [polypeptide binding]; other site 561276008542 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 561276008544 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 561276008545 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 561276008546 Utp21 specific WD40 associated putative domain; Region: Utp21; pfam04192 561276008548 nicotinamide mononucleotide transporter PnuC; Region: NMN_trans_PnuC; TIGR01528 561276008550 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 561276008551 dimer interface [polypeptide binding]; other site 561276008552 conserved gate region; other site 561276008553 ABC-ATPase subunit interface; other site 561276008554 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 561276008555 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 561276008559 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 561276008560 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 561276008561 Walker A/P-loop; other site 561276008562 ATP binding site [chemical binding]; other site 561276008563 Q-loop/lid; other site 561276008564 ABC transporter signature motif; other site 561276008565 Walker B; other site 561276008566 D-loop; other site 561276008567 H-loop/switch region; other site 561276008571 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 561276008572 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 561276008575 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 561276008577 Enterocin A Immunity; Region: EntA_Immun; pfam08951 561276008579 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 561276008580 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 561276008581 oligomer interface [polypeptide binding]; other site 561276008582 active site 561276008583 metal binding site [ion binding]; metal-binding site 561276008585 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 561276008586 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 561276008587 NAD(P) binding site [chemical binding]; other site 561276008588 active site 561276008590 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 561276008591 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 561276008592 ABC-ATPase subunit interface; other site 561276008593 dimer interface [polypeptide binding]; other site 561276008594 putative PBP binding regions; other site 561276008595 8 transmembrane helices predicted for SPN23F18820 by TMHMM2.0 at aa 7-29, 49-66, 107-129,139-161, 182-204, 224-246, 266-288 and 292-314 561276008597 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 561276008598 ABC-ATPase subunit interface; other site 561276008599 dimer interface [polypeptide binding]; other site 561276008600 putative PBP binding regions; other site 561276008601 9 transmembrane helices predicted for SPN23F18830 by TMHMM2.0 at aa 10-32, 45-64, 69-91, 103-124,134-156, 177-196, 237-259, 266-286 and 291-313 561276008603 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 561276008604 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 561276008605 Walker A/P-loop; other site 561276008606 ATP binding site [chemical binding]; other site 561276008607 Q-loop/lid; other site 561276008608 ABC transporter signature motif; other site 561276008609 Walker B; other site 561276008610 D-loop; other site 561276008611 H-loop/switch region; other site 561276008615 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 561276008616 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 561276008617 putative ligand binding residues [chemical binding]; other site 561276008620 hypothetical protein; Validated; Region: PRK00041 561276008622 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 561276008623 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 561276008624 RNA binding surface [nucleotide binding]; other site 561276008625 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 561276008626 active site 561276008630 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 561276008632 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 561276008634 site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436 561276008635 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 561276008636 DNA binding site [nucleotide binding] 561276008637 Int/Topo IB signature motif; other site 561276008638 active site 561276008639 catalytic residues [active] 561276008642 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 561276008643 FOG: CBS domain [General function prediction only]; Region: COG0517 561276008645 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 561276008646 active site 561276008647 metal binding site [ion binding]; metal-binding site 561276008648 homotetramer interface [polypeptide binding]; other site 561276008650 putative deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein; Reviewed; Region: PRK02491 561276008651 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 561276008652 active site 561276008653 dimerization interface [polypeptide binding]; other site 561276008656 glutamate racemase; Provisional; Region: PRK00865 561276008660 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 561276008662 1 transmembrane helix predicted for SPN23F18950 by TMHMM2.0 at aa 4-26 561276008663 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 561276008664 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 561276008665 Ca binding site [ion binding]; other site 561276008666 active site 561276008667 catalytic site [active] 561276008669 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 561276008670 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 561276008671 active site turn [active] 561276008672 phosphorylation site [posttranslational modification] 561276008673 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 561276008674 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 561276008675 HPr interaction site; other site 561276008676 glycerol kinase (GK) interaction site [polypeptide binding]; other site 561276008677 active site 561276008678 phosphorylation site [posttranslational modification] 561276008684 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 561276008685 DNA-binding site [nucleotide binding]; DNA binding site 561276008686 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 561276008687 UTRA domain; Region: UTRA; pfam07702 561276008691 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 561276008692 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 561276008693 Walker A/P-loop; other site 561276008694 ATP binding site [chemical binding]; other site 561276008695 Q-loop/lid; other site 561276008696 ABC transporter signature motif; other site 561276008697 Walker B; other site 561276008698 D-loop; other site 561276008699 H-loop/switch region; other site 561276008702 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 561276008703 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 561276008704 TM-ABC transporter signature motif; other site 561276008706 substrate-binding protein (pseudogene) 561276008709 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 561276008710 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 561276008711 Walker A/P-loop; other site 561276008712 ATP binding site [chemical binding]; other site 561276008713 Q-loop/lid; other site 561276008714 ABC transporter signature motif; other site 561276008715 Walker B; other site 561276008716 D-loop; other site 561276008717 H-loop/switch region; other site 561276008718 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 561276008723 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 561276008724 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 561276008725 Walker A/P-loop; other site 561276008726 ATP binding site [chemical binding]; other site 561276008727 Q-loop/lid; other site 561276008728 ABC transporter signature motif; other site 561276008729 Walker B; other site 561276008730 D-loop; other site 561276008731 H-loop/switch region; other site 561276008732 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 561276008737 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 561276008738 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 561276008739 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 561276008740 dimer interface [polypeptide binding]; other site 561276008741 conserved gate region; other site 561276008742 putative PBP binding loops; other site 561276008743 ABC-ATPase subunit interface; other site 561276008746 potential frameshift: common BLAST hit: gi|169832656|ref|YP_001695255.1| oligopeptide transport system permease protein AmiC 561276008747 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 561276008748 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 561276008749 dimer interface [polypeptide binding]; other site 561276008750 conserved gate region; other site 561276008751 putative PBP binding loops; other site 561276008752 ABC-ATPase subunit interface; other site 561276008755 1 transmembrane helix predicted for SPN23F19090 by TMHMM2.0 at aa 9-31 561276008756 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 561276008757 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 561276008758 peptide binding site [polypeptide binding]; other site 561276008762 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 561276008763 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 561276008765 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 561276008766 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 561276008767 active site 561276008768 homodimer interface [polypeptide binding]; other site 561276008769 catalytic site [active] 561276008771 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 561276008772 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 561276008773 dimer interface [polypeptide binding]; other site 561276008774 conserved gate region; other site 561276008775 putative PBP binding loops; other site 561276008776 ABC-ATPase subunit interface; other site 561276008778 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 561276008779 dimer interface [polypeptide binding]; other site 561276008780 conserved gate region; other site 561276008781 putative PBP binding loops; other site 561276008782 ABC-ATPase subunit interface; other site 561276008785 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 561276008786 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 561276008791 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 561276008792 Melibiase; Region: Melibiase; pfam02065 561276008795 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 561276008796 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 561276008797 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 561276008798 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 561276008803 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 561276008804 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 561276008805 DNA-binding site [nucleotide binding]; DNA binding site 561276008806 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 561276008807 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 561276008811 IS1167 transposase (pseudogene) 561276008813 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 561276008814 TRAM domain; Region: TRAM; cl01282 561276008815 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 561276008816 S-adenosylmethionine binding site [chemical binding]; other site 561276008820 recombination regulator RecX; Provisional; Region: recX; PRK14135 561276008822 hypothetical protein; Provisional; Region: PRK13662 561276008824 IS1167 transposase (pseudogene) 561276008826 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 561276008827 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 561276008828 ring oligomerisation interface [polypeptide binding]; other site 561276008829 ATP/Mg binding site [chemical binding]; other site 561276008830 stacking interactions; other site 561276008831 hinge regions; other site 561276008834 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 561276008835 oligomerisation interface [polypeptide binding]; other site 561276008836 mobile loop; other site 561276008837 roof hairpin; other site 561276008840 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 561276008841 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 561276008842 dimer interface [polypeptide binding]; other site 561276008843 ssDNA binding site [nucleotide binding]; other site 561276008844 tetramer (dimer of dimers) interface [polypeptide binding]; other site 561276008846 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 561276008847 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 561276008848 putative NAD(P) binding site [chemical binding]; other site 561276008849 homodimer interface [polypeptide binding]; other site 561276008850 homotetramer interface [polypeptide binding]; other site 561276008851 active site 561276008854 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 561276008855 putative tRNA-binding site [nucleotide binding]; other site 561276008857 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 561276008858 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 561276008859 catalytic residues [active] 561276008861 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 561276008863 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 561276008864 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 561276008865 LytTr DNA-binding domain; Region: LytTR; pfam04397 561276008867 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 561276008868 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 561276008869 active site 561276008871 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4898 561276008872 ABC transporter ATP-binding protein/permease (pseudogene) 561276008877 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 561276008878 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 561276008880 MarR family; Region: MarR_2; pfam12802 561276008881 Transcriptional regulators [Transcription]; Region: MarR; COG1846 561276008883 hypothetical protein; Provisional; Region: PRK12378 561276008885 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 561276008888 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108 561276008889 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 561276008890 IS1381 transposase (pseudogene) 561276008892 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 561276008893 Domain of unknown function (DUF955); Region: DUF955; cl01076 561276008894 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 561276008895 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 561276008896 non-specific DNA binding site [nucleotide binding]; other site 561276008897 salt bridge; other site 561276008898 sequence-specific DNA binding site [nucleotide binding]; other site 561276008900 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 561276008901 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 561276008902 amidase catalytic site [active] 561276008903 Zn binding residues [ion binding]; other site 561276008904 substrate binding site [chemical binding]; other site 561276008905 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 561276008906 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 561276008913 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 561276008914 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 561276008917 recombinase A; Provisional; Region: recA; PRK09354 561276008918 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 561276008919 hexamer interface [polypeptide binding]; other site 561276008920 Walker A motif; other site 561276008921 ATP binding site [chemical binding]; other site 561276008922 Walker B motif; other site 561276008926 competence damage-inducible protein A; Provisional; Region: PRK00549 561276008927 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 561276008928 putative MPT binding site; other site 561276008929 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 561276008932 Transcriptional regulator [Transcription]; Region: LytR; COG1316 561276008934 1 transmembrane helix predicted for SPN23F19640 by TMHMM2.0 at aa 5-27 561276008935 putative acetyltransferase YhhY; Provisional; Region: PRK10140 561276008936 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 561276008937 Coenzyme A binding pocket [chemical binding]; other site 561276008939 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 561276008942 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 561276008943 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 561276008944 non-specific DNA binding site [nucleotide binding]; other site 561276008945 salt bridge; other site 561276008946 sequence-specific DNA binding site [nucleotide binding]; other site 561276008948 type 2 lantibiotic, SP_1948 family; Region: lant_SP_1948; TIGR03893 561276008949 type 2 lantibiotic, SP_1948 family; Region: lant_SP_1948; TIGR03893 561276008950 Lantibiotic modifying enzyme [Defense mechanisms]; Region: LcnDR2; COG4403 561276008951 LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792 561276008952 active site 561276008953 zinc binding site [ion binding]; other site 561276008955 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 561276008956 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709 561276008957 active site 561276008958 putative substrate binding region [chemical binding]; other site 561276008959 5 transmembrane helices predicted for SPN23F19740 by TMHMM2.0 at aa 7-26, 36-58, 70-92, 107-129 and 136-155 561276008961 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 561276008962 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39F; cd02425 561276008963 putative active site [active] 561276008964 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 561276008965 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 561276008966 Walker A/P-loop; other site 561276008967 ATP binding site [chemical binding]; other site 561276008968 Q-loop/lid; other site 561276008969 ABC transporter signature motif; other site 561276008970 Walker B; other site 561276008971 D-loop; other site 561276008972 H-loop/switch region; other site 561276008975 6 transmembrane helices predicted for SPN23F19750 by TMHMM2.0 at aa 157-179, 194-216, 265-287,292-314, 374-396 and 406-428 561276008979 Peptidase S8 family domain in Lantiobiotic (lanthionine-containing antibiotics) specific proteases; Region: Peptidases_S8_Lantibiotic_specific_protease; cd07482 561276008980 active site 561276008981 catalytic triad [active] 561276008984 1 transmembrane helix predicted for SPN23F19760 by TMHMM2.0 at aa 552-574 561276008985 membrane protein (pseudogene) 561276008986 3 transmembrane helices predicted for SPN23F19770 by TMHMM2.0 at aa 151-173, 193-215 and 220-239 561276008988 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 561276008989 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 561276008990 Walker A/P-loop; other site 561276008991 ATP binding site [chemical binding]; other site 561276008992 Q-loop/lid; other site 561276008993 ABC transporter signature motif; other site 561276008994 Walker B; other site 561276008995 D-loop; other site 561276008996 H-loop/switch region; other site 561276009001 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 561276009002 active site 561276009003 multimer interface [polypeptide binding]; other site 561276009006 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 561276009007 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 561276009008 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 561276009009 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 561276009010 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 561276009011 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 561276009012 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 561276009013 G-loop; other site 561276009014 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 561276009015 DNA binding site [nucleotide binding] 561276009016 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 561276009022 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 561276009023 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 561276009024 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 561276009025 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 561276009026 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 561276009027 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 561276009028 RPB1 interaction site [polypeptide binding]; other site 561276009029 RPB10 interaction site [polypeptide binding]; other site 561276009030 RPB11 interaction site [polypeptide binding]; other site 561276009031 RPB3 interaction site [polypeptide binding]; other site 561276009032 RPB12 interaction site [polypeptide binding]; other site 561276009040 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 561276009041 Domain of unknown function DUF21; Region: DUF21; pfam01595 561276009042 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 561276009043 Transporter associated domain; Region: CorC_HlyC; smart01091 561276009047 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 561276009048 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; pfam01223 561276009051 1 transmembrane helix predicted for SPN23F19840 by TMHMM2.0 at aa 7-25 561276009052 DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772 561276009053 1 transmembrane helix predicted for SPN23F19850 by TMHMM2.0 at aa 12-34 561276009054 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 561276009055 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 561276009056 hinge; other site 561276009057 active site 561276009059 Protein of unknown function (DUF1146); Region: DUF1146; pfam06612 561276009060 1 transmembrane helix predicted for SPN23F19870 by TMHMM2.0 at aa 34-56 561276009061 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 561276009062 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 561276009063 protein binding site [polypeptide binding]; other site 561276009064 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 561276009065 1 transmembrane helix predicted for SPN23F19880 by TMHMM2.0 at aa 7-29 561276009066 Phosphopantetheine adenylyltransferase [Coenzyme metabolism]; Region: CoaD; COG0669 561276009067 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 561276009068 active site 561276009069 (T/H)XGH motif; other site 561276009071 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 561276009072 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 561276009073 S-adenosylmethionine binding site [chemical binding]; other site 561276009076 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 561276009077 dimer interface [polypeptide binding]; other site 561276009078 active site 561276009080 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 561276009081 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 561276009083 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 561276009084 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 561276009085 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 561276009088 acylphosphatase; Provisional; Region: PRK14434 561276009090 OxaA-like protein precursor; Provisional; Region: PRK02463 561276009091 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 561276009092 6 transmembrane helices predicted for SPN23F19960 by TMHMM2.0 at aa 7-26, 58-80, 131-153,168-190, 211-225 and 230-252 561276009094 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 561276009095 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 561276009096 FeS/SAM binding site; other site 561276009100 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 561276009101 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 561276009102 active site 561276009103 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 561276009104 substrate binding site [chemical binding]; other site 561276009105 catalytic residues [active] 561276009106 dimer interface [polypeptide binding]; other site 561276009109 pur operon repressor; Provisional; Region: PRK09213 561276009110 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 561276009111 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 561276009112 active site 561276009116 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 561276009117 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 561276009118 generic binding surface II; other site 561276009119 generic binding surface I; other site 561276009120 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 561276009121 Zn2+ binding site [ion binding]; other site 561276009122 Mg2+ binding site [ion binding]; other site 561276009125 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 561276009126 RmuC family; Region: RmuC; pfam02646 561276009128 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 561276009129 Thiamine pyrophosphokinase; Region: TPK; cd07995 561276009130 active site 561276009131 dimerization interface [polypeptide binding]; other site 561276009132 thiamine binding site [chemical binding]; other site 561276009135 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 561276009136 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 561276009137 substrate binding site [chemical binding]; other site 561276009138 hexamer interface [polypeptide binding]; other site 561276009139 metal binding site [ion binding]; metal-binding site 561276009142 GTPase RsgA; Reviewed; Region: PRK00098 561276009143 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 561276009144 RNA binding site [nucleotide binding]; other site 561276009145 homodimer interface [polypeptide binding]; other site 561276009146 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 561276009147 GTPase/Zn-binding domain interface [polypeptide binding]; other site 561276009148 GTP/Mg2+ binding site [chemical binding]; other site 561276009149 G4 box; other site 561276009150 G5 box; other site 561276009151 G1 box; other site 561276009152 Switch I region; other site 561276009153 G2 box; other site 561276009154 G3 box; other site 561276009155 Switch II region; other site 561276009158 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 561276009159 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 561276009160 S-adenosylmethionine binding site [chemical binding]; other site 561276009163 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 561276009164 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 561276009165 Walker A/P-loop; other site 561276009166 ATP binding site [chemical binding]; other site 561276009167 Q-loop/lid; other site 561276009168 ABC transporter signature motif; other site 561276009169 Walker B; other site 561276009170 D-loop; other site 561276009171 H-loop/switch region; other site 561276009175 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 561276009176 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 561276009178 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891 561276009179 1 transmembrane helix predicted for SPN23F20090 by TMHMM2.0 at aa 7-29 561276009180 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 561276009181 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 561276009182 non-specific DNA binding site [nucleotide binding]; other site 561276009183 salt bridge; other site 561276009184 sequence-specific DNA binding site [nucleotide binding]; other site 561276009186 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 561276009187 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 561276009188 putative active site [active] 561276009189 putative metal binding site [ion binding]; other site 561276009190 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 561276009192 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 561276009193 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 561276009194 active site 561276009197 gene model created manually to include N-terminal signal sequence; surface anchored protein (pseudogene) 561276009199 1 transmembrane helix predicted for SPN23F20130 by TMHMM2.0 at aa 268-290 561276009202 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 561276009205 aminotransferase AlaT; Validated; Region: PRK09265 561276009206 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 561276009207 pyridoxal 5'-phosphate binding site [chemical binding]; other site 561276009208 homodimer interface [polypeptide binding]; other site 561276009209 catalytic residue [active] 561276009211 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 561276009212 Ligand Binding Site [chemical binding]; other site 561276009214 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 561276009215 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 561276009216 active site 561276009217 motif I; other site 561276009218 motif II; other site 561276009219 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 561276009220 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545 561276009221 putative nucleotide binding site [chemical binding]; other site 561276009222 putative metal binding site [ion binding]; other site 561276009226 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 561276009227 active site 561276009228 homotetramer interface [polypeptide binding]; other site 561276009229 homodimer interface [polypeptide binding]; other site 561276009233 catabolite control protein A; Region: ccpA; TIGR01481 561276009234 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 561276009235 DNA binding site [nucleotide binding] 561276009236 domain linker motif; other site 561276009237 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 561276009238 dimerization interface [polypeptide binding]; other site 561276009239 effector binding site; other site 561276009243 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 561276009244 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 561276009245 active site 561276009246 phosphorylation site [posttranslational modification] 561276009247 intermolecular recognition site; other site 561276009248 dimerization interface [polypeptide binding]; other site 561276009249 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 561276009250 DNA binding residues [nucleotide binding] 561276009251 dimerization interface [polypeptide binding]; other site 561276009255 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 561276009256 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; cl02333 561276009257 Histidine kinase; Region: HisKA_3; pfam07730 561276009258 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 561276009259 ATP binding site [chemical binding]; other site 561276009260 Mg2+ binding site [ion binding]; other site 561276009261 G-X-G motif; other site 561276009264 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 561276009265 ABC-2 type transporter; Region: ABC2_membrane; cl17235 561276009267 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 561276009268 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 561276009269 Walker A/P-loop; other site 561276009270 ATP binding site [chemical binding]; other site 561276009271 Q-loop/lid; other site 561276009272 ABC transporter signature motif; other site 561276009273 Walker B; other site 561276009274 D-loop; other site 561276009275 H-loop/switch region; other site 561276009279 manually curated to include N-terminal signal sequence; exported protein (pseudogene) 561276009280 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 561276009282 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 561276009283 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 561276009284 putative homodimer interface [polypeptide binding]; other site 561276009285 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 561276009286 heterodimer interface [polypeptide binding]; other site 561276009287 homodimer interface [polypeptide binding]; other site 561276009290 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 561276009291 1 transmembrane helix predicted for SPN23F20300 by TMHMM2.0 at aa 33-55 561276009292 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 561276009293 Transglycosylase; Region: Transgly; pfam00912 561276009294 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 561276009297 1 transmembrane helix predicted for SPN23F20310 by TMHMM2.0 at aa 57-76 561276009298 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 561276009299 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 561276009300 active site 561276009303 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 561276009304 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 561276009305 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 561276009309 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 561276009310 FtsX-like permease family; Region: FtsX; pfam02687 561276009312 IS630-Spn1 transposase (pseudogene) 561276009314 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06559 561276009315 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 561276009316 dimerization interface [polypeptide binding]; other site 561276009317 active site 561276009320 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 561276009321 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 561276009323 9 transmembrane helices predicted for SPN23F20380 by TMHMM2.0 at aa 21-43, 47-69, 90-112,172-194, 226-245, 260-277, 282-304, 324-358 and 411-433 561276009325 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 561276009326 Walker A/P-loop; other site 561276009327 ATP binding site [chemical binding]; other site 561276009329 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 561276009330 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 561276009331 DNA-binding site [nucleotide binding]; DNA binding site 561276009332 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 561276009335 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 561276009336 beta-galactosidase; Region: BGL; TIGR03356 561276009338 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 561276009339 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 561276009341 10 transmembrane helices predicted for SPN23F20430 by TMHMM2.0 at aa 33-55, 68-90, 100-122,134-156, 185-207, 227-249, 289-311, 343-365, 370-392 and 399-418 561276009342 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 561276009343 active site 561276009344 P-loop; other site 561276009345 phosphorylation site [posttranslational modification] 561276009347 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 561276009348 methionine cluster; other site 561276009349 active site 561276009350 phosphorylation site [posttranslational modification] 561276009351 metal binding site [ion binding]; metal-binding site 561276009353 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 561276009354 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 561276009355 putative catalytic cysteine [active] 561276009356 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 561276009357 putative active site [active] 561276009358 metal binding site [ion binding]; metal-binding site 561276009362 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 561276009363 MORN repeat; Region: MORN; cl14787 561276009367 1 transmembrane helix predicted for SPN23F20480 by TMHMM2.0 at aa 20-42 561276009368 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 561276009369 Low molecular weight phosphatase family; Region: LMWPc; cd00115 561276009370 active site 561276009372 preprotein translocase subunit YajC; Validated; Region: yajC; PRK06531 561276009374 1 transmembrane helix predicted for SPN23F20500 by TMHMM2.0 at aa 5-22 561276009375 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 561276009376 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 561276009377 TPP-binding site [chemical binding]; other site 561276009378 dimer interface [polypeptide binding]; other site 561276009379 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 561276009380 PYR/PP interface [polypeptide binding]; other site 561276009381 dimer interface [polypeptide binding]; other site 561276009382 TPP binding site [chemical binding]; other site 561276009383 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 561276009389 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 561276009390 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 561276009391 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 561276009392 PRD domain; Region: PRD; pfam00874 561276009393 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 561276009394 active site 561276009395 P-loop; other site 561276009396 phosphorylation site [posttranslational modification] 561276009401 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 561276009402 L-ribulose-5-phosphate 4-epimerase; Provisional; Region: araD; PRK13145 561276009403 intersubunit interface [polypeptide binding]; other site 561276009404 active site 561276009405 Zn2+ binding site [ion binding]; other site 561276009407 hexulose-6-phosphate isomerase (pseudogene) 561276009410 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 561276009411 active site 561276009412 dimer interface [polypeptide binding]; other site 561276009413 magnesium binding site [ion binding]; other site 561276009415 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 561276009416 active site 561276009417 phosphorylation site [posttranslational modification] 561276009419 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 561276009420 active site 561276009421 P-loop; other site 561276009422 phosphorylation site [posttranslational modification] 561276009424 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 561276009426 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 561276009427 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 561276009428 G-X-X-G motif; other site 561276009429 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 561276009430 RxxxH motif; other site 561276009432 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 561276009433 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 561276009435 ribonuclease P; Reviewed; Region: rnpA; PRK00499 561276009438 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 561276009439 propionate/acetate kinase; Provisional; Region: PRK12379 561276009442 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 561276009443 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 561276009444 S-adenosylmethionine binding site [chemical binding]; other site 561276009445 methyltransferase (pseudogene) 561276009447 1 transmembrane helix predicted for SPN23F20700 by TMHMM2.0 at aa 7-29 561276009448 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 561276009449 1 transmembrane helix predicted for SPN23F20710 by TMHMM2.0 at aa 17-39 561276009450 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 561276009451 Type II secretory pathway pseudopilin; Region: PulG; pfam11773 561276009452 1 transmembrane helix predicted for SPN23F20720 by TMHMM2.0 at aa 2-24 561276009453 1 transmembrane helix predicted for SPN23F20730 by TMHMM2.0 at aa 12-34 561276009454 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 561276009456 1 transmembrane helix predicted for SPN23F20740 by TMHMM2.0 at aa 15-37 561276009457 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 561276009458 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 561276009459 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 561276009463 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 561276009464 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 561276009465 Walker A motif; other site 561276009466 ATP binding site [chemical binding]; other site 561276009467 Walker B motif; other site 561276009471 Protein of unknown function (DUF1033); Region: DUF1033; pfam06279 561276009473 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 561276009474 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 561276009475 catalytic Zn binding site [ion binding]; other site 561276009476 structural Zn binding site [ion binding]; other site 561276009477 NAD(P) binding site [chemical binding]; other site 561276009481 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 561276009482 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 561276009483 active site 561276009484 dimer interface [polypeptide binding]; other site 561276009486 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 561276009487 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 561276009488 catalytic triad [active] 561276009489 catalytic triad [active] 561276009490 oxyanion hole [active] 561276009492 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 561276009493 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 561276009495 Predicted integral membrane protein [Function unknown]; Region: COG5523 561276009497 5 transmembrane helices predicted for SPN23F20820 by TMHMM2.0 at aa 26-48, 68-90, 126-148,172-194 and 244-266 561276009498 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 561276009499 putative substrate binding pocket [chemical binding]; other site 561276009500 AC domain interface; other site 561276009501 catalytic triad [active] 561276009502 AB domain interface; other site 561276009503 interchain disulfide; other site 561276009505 Predicted membrane protein [Function unknown]; Region: COG3759 561276009507 Transcriptional regulators [Transcription]; Region: MarR; COG1846 561276009508 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 561276009509 putative DNA binding site [nucleotide binding]; other site 561276009510 putative Zn2+ binding site [ion binding]; other site 561276009512 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 561276009514 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 561276009515 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 561276009516 motif II; other site 561276009518 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 561276009519 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 561276009522 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 561276009523 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 561276009524 pyridoxal 5'-phosphate binding site [chemical binding]; other site 561276009525 catalytic residue [active] 561276009528 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572 561276009530 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 561276009531 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 561276009532 active site 561276009533 HIGH motif; other site 561276009534 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 561276009535 active site 561276009536 KMSKS motif; other site 561276009537 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 561276009540 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 561276009541 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 561276009542 active site 561276009543 dimer interface [polypeptide binding]; other site 561276009544 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 561276009545 dimer interface [polypeptide binding]; other site 561276009546 active site 561276009549 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 561276009550 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 561276009551 catalytic triad [active] 561276009553 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 561276009554 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 561276009555 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 561276009556 Walker A/P-loop; other site 561276009557 ATP binding site [chemical binding]; other site 561276009558 Q-loop/lid; other site 561276009559 ABC transporter signature motif; other site 561276009560 Walker B; other site 561276009561 D-loop; other site 561276009562 H-loop/switch region; other site 561276009568 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 561276009569 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 561276009570 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 561276009571 Walker A/P-loop; other site 561276009572 ATP binding site [chemical binding]; other site 561276009573 Q-loop/lid; other site 561276009574 ABC transporter signature motif; other site 561276009575 Walker B; other site 561276009576 D-loop; other site 561276009577 H-loop/switch region; other site 561276009583 DNA mismatch repair protein MutS; Region: mutS1; TIGR01070 561276009584 MutS domain I; Region: MutS_I; pfam01624 561276009585 MutS domain II; Region: MutS_II; pfam05188 561276009586 MutS domain III; Region: MutS_III; pfam05192 561276009587 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 561276009588 Walker A/P-loop; other site 561276009589 ATP binding site [chemical binding]; other site 561276009590 Q-loop/lid; other site 561276009591 ABC transporter signature motif; other site 561276009592 Walker B; other site 561276009593 D-loop; other site 561276009594 H-loop/switch region; other site 561276009602 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 561276009603 arginine repressor; Region: argR_whole; TIGR01529 561276009604 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 561276009607 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 561276009608 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 561276009609 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 561276009610 active site 561276009611 HIGH motif; other site 561276009612 KMSK motif region; other site 561276009613 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 561276009614 tRNA binding surface [nucleotide binding]; other site 561276009615 anticodon binding site; other site 561276009619 IS1381 transposase (pseudogene) 561276009621 Uncharacterized conserved protein [Function unknown]; Region: COG3542 561276009623 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 561276009624 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 561276009625 active site 561276009626 phosphorylation site [posttranslational modification] 561276009627 intermolecular recognition site; other site 561276009628 dimerization interface [polypeptide binding]; other site 561276009629 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 561276009630 DNA binding site [nucleotide binding] 561276009633 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 561276009634 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 561276009635 dimer interface [polypeptide binding]; other site 561276009636 phosphorylation site [posttranslational modification] 561276009637 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 561276009638 ATP binding site [chemical binding]; other site 561276009639 G-X-G motif; other site 561276009640 1 transmembrane helix predicted for SPN23F21080 by TMHMM2.0 at aa 7-26 561276009643 PBP superfamily domain; Region: PBP_like_2; cl17296 561276009644 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 561276009646 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 561276009647 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 561276009648 dimer interface [polypeptide binding]; other site 561276009649 conserved gate region; other site 561276009650 putative PBP binding loops; other site 561276009651 ABC-ATPase subunit interface; other site 561276009652 5 transmembrane helices predicted for SPN23F21100 by TMHMM2.0 at aa 13-35, 74-96, 109-131,141-163 and 258-280 561276009654 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 561276009655 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 561276009656 dimer interface [polypeptide binding]; other site 561276009657 conserved gate region; other site 561276009658 putative PBP binding loops; other site 561276009659 ABC-ATPase subunit interface; other site 561276009660 6 transmembrane helices predicted for SPN23F21110 by TMHMM2.0 at aa 7-29, 60-82, 102-124,128-145, 176-198 and 241-263 561276009663 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 561276009664 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 561276009665 Walker A/P-loop; other site 561276009666 ATP binding site [chemical binding]; other site 561276009667 Q-loop/lid; other site 561276009668 ABC transporter signature motif; other site 561276009669 Walker B; other site 561276009670 D-loop; other site 561276009671 H-loop/switch region; other site 561276009675 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 561276009676 PhoU domain; Region: PhoU; pfam01895 561276009677 PhoU domain; Region: PhoU; pfam01895 561276009682 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 561276009683 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 561276009684 non-specific DNA binding site [nucleotide binding]; other site 561276009685 salt bridge; other site 561276009686 sequence-specific DNA binding site [nucleotide binding]; other site 561276009688 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 561276009689 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 561276009690 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 561276009693 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 561276009694 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 561276009695 active site 561276009696 tetramer interface; other site 561276009698 Rhomboid family; Region: Rhomboid; pfam01694 561276009700 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 561276009701 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 561276009703 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 561276009704 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 561276009705 metal binding site [ion binding]; metal-binding site 561276009706 putative dimer interface [polypeptide binding]; other site 561276009709 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 561276009710 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 561276009711 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 561276009712 trimer interface [polypeptide binding]; other site 561276009713 active site 561276009714 substrate binding site [chemical binding]; other site 561276009715 CoA binding site [chemical binding]; other site 561276009724 EamA-like transporter family; Region: EamA; pfam00892 561276009727 Transglycosylase; Region: Transgly; pfam00912 561276009728 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 561276009729 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 561276009732 1 transmembrane helix predicted for SPN23F21230 by TMHMM2.0 at aa 60-82 561276009733 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 561276009734 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 561276009735 active site 561276009736 HIGH motif; other site 561276009737 dimer interface [polypeptide binding]; other site 561276009738 KMSKS motif; other site 561276009739 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 561276009740 RNA binding surface [nucleotide binding]; other site 561276009744 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 561276009745 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 561276009746 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 561276009747 motif II; other site 561276009751 1 transmembrane helix predicted for SPN23F21260 by TMHMM2.0 at aa 15-34 561276009752 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 561276009753 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 561276009754 S-adenosylmethionine binding site [chemical binding]; other site 561276009756 2 transmembrane helices predicted for SPN23F21290 by TMHMM2.0 at aa 7-29 and 107-129 561276009757 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 561276009758 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 561276009761 4-alpha-glucanotransferase; Provisional; Region: PRK14508 561276009763 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 561276009764 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 561276009768 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 561276009769 dimer interface [polypeptide binding]; other site 561276009770 conserved gate region; other site 561276009771 putative PBP binding loops; other site 561276009772 ABC-ATPase subunit interface; other site 561276009774 8 transmembrane helices predicted for SPN23F21340 by TMHMM2.0 at aa 29-48, 68-90, 123-145,192-214, 226-245, 287-309, 331-353 and 397-419 561276009777 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 561276009778 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 561276009779 dimer interface [polypeptide binding]; other site 561276009780 conserved gate region; other site 561276009781 putative PBP binding loops; other site 561276009782 ABC-ATPase subunit interface; other site 561276009783 5 transmembrane helices predicted for SPN23F21350 by TMHMM2.0 at aa 17-39, 76-98, 110-132,142-159 and 244-266 561276009786 Predicted integral membrane protein [Function unknown]; Region: COG5521 561276009787 4 transmembrane helices predicted for SPN23F21360 by TMHMM2.0 at aa 25-47, 164-195, 210-232 and 237-259 561276009788 Transcriptional regulators [Transcription]; Region: PurR; COG1609 561276009789 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 561276009790 DNA binding site [nucleotide binding] 561276009791 domain linker motif; other site 561276009792 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 561276009793 putative dimerization interface [polypeptide binding]; other site 561276009794 putative ligand binding site [chemical binding]; other site 561276009798 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 561276009799 Transposase; Region: DDE_Tnp_ISL3; pfam01610 561276009801 Uncharacterized conserved protein [Function unknown]; Region: COG1284 561276009802 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 561276009803 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 561276009804 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 561276009807 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 561276009808 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 561276009809 dimer interface [polypeptide binding]; other site 561276009810 anticodon binding site; other site 561276009811 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 561276009812 homodimer interface [polypeptide binding]; other site 561276009813 motif 1; other site 561276009814 active site 561276009815 motif 2; other site 561276009816 GAD domain; Region: GAD; pfam02938 561276009817 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 561276009818 motif 3; other site 561276009824 CAAX protease self-immunity; Region: Abi; pfam02517 561276009826 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 561276009827 1 transmembrane helix predicted for SPN23F21460 by TMHMM2.0 at aa 7-29 561276009828 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 561276009829 non-specific DNA binding site [nucleotide binding]; other site 561276009830 salt bridge; other site 561276009831 sequence-specific DNA binding site [nucleotide binding]; other site 561276009833 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 561276009834 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 561276009835 dimer interface [polypeptide binding]; other site 561276009836 motif 1; other site 561276009837 active site 561276009838 motif 2; other site 561276009839 motif 3; other site 561276009840 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 561276009841 anticodon binding site; other site 561276009846 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 561276009848 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 561276009849 non-specific DNA binding site [nucleotide binding]; other site 561276009850 salt bridge; other site 561276009851 sequence-specific DNA binding site [nucleotide binding]; other site 561276009852 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 561276009853 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 561276009854 Helix-turn-helix domain; Region: HTH_38; pfam13936 561276009855 Integrase core domain; Region: rve; pfam00665 561276009857 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 561276009859 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 561276009863 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 561276009864 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 561276009865 PYR/PP interface [polypeptide binding]; other site 561276009866 dimer interface [polypeptide binding]; other site 561276009867 TPP binding site [chemical binding]; other site 561276009868 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 561276009871 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 561276009872 TPP-binding site [chemical binding]; other site 561276009873 dimer interface [polypeptide binding]; other site 561276009875 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 561276009877 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 561276009878 active site 561276009879 P-loop; other site 561276009880 phosphorylation site [posttranslational modification] 561276009882 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 561276009883 PRD domain; Region: PRD; pfam00874 561276009884 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 561276009885 active site 561276009886 P-loop; other site 561276009887 phosphorylation site [posttranslational modification] 561276009888 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 561276009889 active site 561276009890 phosphorylation site [posttranslational modification] 561276009894 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 561276009895 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 561276009896 2 transmembrane helices predicted for SPN23F21640 by TMHMM2.0 at aa 12-34 and 39-61 561276009898 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 561276009899 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 561276009901 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 561276009903 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 561276009904 Transposase; Region: DDE_Tnp_ISL3; pfam01610 561276009906 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 561276009907 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 561276009908 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 561276009909 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 561276009910 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 561276009911 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 561276009912 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 561276009913 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 561276009914 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 561276009924 IS1381 transposase (pseudogene) 561276009926 IS1381 transposase (pseudogene) 561276009928 hypothetical protein (pseudogene) 561276009929 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 561276009930 putative active site [active] 561276009932 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 561276009933 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 561276009934 nucleotide binding site [chemical binding]; other site 561276009936 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 561276009937 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 561276009938 active site 561276009939 metal binding site [ion binding]; metal-binding site 561276009940 homodimer interface [polypeptide binding]; other site 561276009941 catalytic site [active] 561276009942 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 561276009945 Uncharacterized conserved protein [Function unknown]; Region: COG3538 561276009946 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 561276009948 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 561276009949 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 561276009952 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 561276009953 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 561276009954 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 561276009955 arginine deiminase; Provisional; Region: PRK01388 561276009957 ornithine carbamoyltransferase; Validated; Region: PRK02102 561276009958 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 561276009959 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 561276009963 carbamate kinase; Reviewed; Region: PRK12686 561276009964 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 561276009965 putative substrate binding site [chemical binding]; other site 561276009966 nucleotide binding site [chemical binding]; other site 561276009967 nucleotide binding site [chemical binding]; other site 561276009968 homodimer interface [polypeptide binding]; other site 561276009970 Predicted membrane protein [Function unknown]; Region: COG1288 561276009971 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 561276009973 12 transmembrane helices predicted for SPN23F21830 by TMHMM2.0 at aa 13-32, 85-107, 120-139,149-171, 173-195, 200-222, 264-283, 317-339, 346-368,396-418, 450-472 and 482-502 561276009974 hypothetical protein; Provisional; Region: PRK07205 561276009975 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 561276009976 active site 561276009977 metal binding site [ion binding]; metal-binding site 561276009982 1 transmembrane helix predicted for SPN23F21870 by TMHMM2.0 at aa 13-35 561276009984 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 561276009985 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 561276009987 1 transmembrane helix predicted for SPN23F21880 by TMHMM2.0 at aa 5-27 561276009988 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 561276009989 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 561276009990 dimer interface [polypeptide binding]; other site 561276009991 active site 561276009992 metal binding site [ion binding]; metal-binding site 561276009997 L-fucose isomerase; Provisional; Region: fucI; PRK10991 561276009998 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 561276009999 hexamer (dimer of trimers) interface [polypeptide binding]; other site 561276010000 trimer interface [polypeptide binding]; other site 561276010001 substrate binding site [chemical binding]; other site 561276010002 Mn binding site [ion binding]; other site 561276010006 Glycosyl hydrolase family 98; Region: Glyco_hydro_98M; pfam08306 561276010007 Glycosyl hydrolase family 98 C-terminal domain; Region: Glyco_hydro_98C; pfam08307 561276010008 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 561276010009 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 561276010010 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 561276010016 1 transmembrane helix predicted for SPN23F21910 by TMHMM2.0 at aa 12-29 561276010017 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 561276010019 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 561276010021 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 561276010022 active site 561276010023 phosphorylation site [posttranslational modification] 561276010025 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 561276010026 active pocket/dimerization site; other site 561276010027 active site 561276010028 phosphorylation site [posttranslational modification] 561276010030 Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154 561276010032 L-fuculose phosphate aldolase; Provisional; Region: PRK06833 561276010033 intersubunit interface [polypeptide binding]; other site 561276010034 active site 561276010035 Zn2+ binding site [ion binding]; other site 561276010037 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 561276010038 N- and C-terminal domain interface [polypeptide binding]; other site 561276010039 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 561276010040 active site 561276010041 putative catalytic site [active] 561276010042 metal binding site [ion binding]; metal-binding site 561276010043 ATP binding site [chemical binding]; other site 561276010044 carbohydrate binding site [chemical binding]; other site 561276010047 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 561276010048 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 561276010049 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 561276010053 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 561276010054 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 561276010055 metal binding site [ion binding]; metal-binding site 561276010056 YodA lipocalin-like domain; Region: YodA; pfam09223 561276010060 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 561276010061 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 561276010062 ABC-ATPase subunit interface; other site 561276010063 dimer interface [polypeptide binding]; other site 561276010064 putative PBP binding regions; other site 561276010066 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 561276010067 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 561276010070 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 561276010071 putative DNA binding site [nucleotide binding]; other site 561276010073 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 561276010074 DltD N-terminal region; Region: DltD_N; pfam04915 561276010075 DltD central region; Region: DltD_M; pfam04918 561276010076 DltD C-terminal region; Region: DltD_C; pfam04914 561276010080 1 transmembrane helix predicted for SPN23F22060 by TMHMM2.0 at aa 5-27 561276010081 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 561276010083 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 561276010085 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 561276010086 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 561276010087 acyl-activating enzyme (AAE) consensus motif; other site 561276010088 AMP binding site [chemical binding]; other site 561276010092 1 transmembrane helix predicted for SPN23F22100 by TMHMM2.0 at aa 7-29 561276010093 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 561276010094 putative substrate translocation pore; other site 561276010096 reverse transcriptase-Group II intron (pseudogene) 561276010101 1 transmembrane helix predicted for SPN23F22150 by TMHMM2.0 at aa 119-141 561276010102 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 561276010103 amphipathic channel; other site 561276010104 Asn-Pro-Ala signature motifs; other site 561276010107 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 561276010109 1 transmembrane helix predicted for SPN23F22190 by TMHMM2.0 at aa 21-43 561276010110 glycerol kinase; Provisional; Region: glpK; PRK00047 561276010111 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 561276010112 N- and C-terminal domain interface [polypeptide binding]; other site 561276010113 active site 561276010114 MgATP binding site [chemical binding]; other site 561276010115 catalytic site [active] 561276010116 metal binding site [ion binding]; metal-binding site 561276010117 glycerol binding site [chemical binding]; other site 561276010118 homotetramer interface [polypeptide binding]; other site 561276010119 homodimer interface [polypeptide binding]; other site 561276010120 FBP binding site [chemical binding]; other site 561276010121 protein IIAGlc interface [polypeptide binding]; other site 561276010126 Mga helix-turn-helix domain; Region: Mga; pfam05043 561276010128 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 561276010129 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 561276010130 dimerization interface [polypeptide binding]; other site 561276010131 domain crossover interface; other site 561276010132 redox-dependent activation switch; other site 561276010134 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 561276010135 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 561276010136 FMN binding site [chemical binding]; other site 561276010137 active site 561276010138 catalytic residues [active] 561276010139 substrate binding site [chemical binding]; other site 561276010143 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 561276010144 RICH domain; Region: RICH; pfam05062 561276010145 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 561276010146 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 561276010147 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 561276010148 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 561276010149 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 561276010150 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 561276010151 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 561276010152 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 561276010153 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 561276010165 1 transmembrane helix predicted for SPN23F22240 by TMHMM2.0 at aa 13-35 561276010167 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 561276010169 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 561276010170 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 561276010171 dimerization interface [polypeptide binding]; other site 561276010172 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 561276010173 dimer interface [polypeptide binding]; other site 561276010174 phosphorylation site [posttranslational modification] 561276010175 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 561276010176 ATP binding site [chemical binding]; other site 561276010177 Mg2+ binding site [ion binding]; other site 561276010178 G-X-G motif; other site 561276010182 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 561276010183 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 561276010184 active site 561276010185 phosphorylation site [posttranslational modification] 561276010186 intermolecular recognition site; other site 561276010187 dimerization interface [polypeptide binding]; other site 561276010188 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 561276010189 DNA binding site [nucleotide binding] 561276010192 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 561276010193 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 561276010194 Walker A motif; other site 561276010195 ATP binding site [chemical binding]; other site 561276010196 Walker B motif; other site 561276010197 arginine finger; other site 561276010198 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 561276010199 Walker A motif; other site 561276010200 ATP binding site [chemical binding]; other site 561276010201 Walker B motif; other site 561276010202 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 561276010211 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 561276010214 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 561276010215 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 561276010216 Walker A/P-loop; other site 561276010217 ATP binding site [chemical binding]; other site 561276010218 Q-loop/lid; other site 561276010219 ABC transporter signature motif; other site 561276010220 Walker B; other site 561276010221 D-loop; other site 561276010222 H-loop/switch region; other site 561276010227 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 561276010228 NMT1/THI5 like; Region: NMT1; pfam09084 561276010230 1 transmembrane helix predicted for SPN23F22310 by TMHMM2.0 at aa 7-29 561276010232 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 561276010233 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 561276010235 Uncharacterized conserved protein [Function unknown]; Region: COG0011 561276010238 Surface antigen [General function prediction only]; Region: COG3942 561276010239 CHAP domain; Region: CHAP; pfam05257 561276010240 Bacterial SH3 domain; Region: SH3_5; pfam08460 561276010241 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 561276010242 Bacterial SH3 domain; Region: SH3_5; pfam08460 561276010243 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 561276010251 Uncharacterized protein conserved in bacteria [Function unknown]; Region: Veg; COG4466 561276010253 replicative DNA helicase; Provisional; Region: PRK05748 561276010254 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 561276010255 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 561276010256 Walker A motif; other site 561276010257 ATP binding site [chemical binding]; other site 561276010258 Walker B motif; other site 561276010259 DNA binding loops [nucleotide binding] 561276010263 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 561276010264 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 561276010265 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 561276010269 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 561276010270 DHH family; Region: DHH; pfam01368 561276010271 DHHA1 domain; Region: DHHA1; pfam02272 561276010274 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 561276010275 30S subunit binding site; other site 561276010277 comF family protein; Region: comF; TIGR00201 561276010278 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 561276010279 active site 561276010281 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 561276010282 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 561276010283 ATP binding site [chemical binding]; other site 561276010284 putative Mg++ binding site [ion binding]; other site 561276010285 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 561276010286 nucleotide binding region [chemical binding]; other site 561276010287 ATP-binding site [chemical binding]; other site 561276010291 Uncharacterized conserved protein [Function unknown]; Region: COG1739 561276010292 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 561276010293 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 561276010297 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 561276010298 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 561276010299 dimer interface [polypeptide binding]; other site 561276010300 pyridoxal 5'-phosphate binding site [chemical binding]; other site 561276010301 catalytic residue [active] 561276010309 elongation factor Ts; Provisional; Region: tsf; PRK09377 561276010310 UBA/TS-N domain; Region: UBA; pfam00627 561276010311 Elongation factor TS; Region: EF_TS; pfam00889 561276010312 Elongation factor TS; Region: EF_TS; pfam00889 561276010315 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 561276010316 rRNA interaction site [nucleotide binding]; other site 561276010317 S8 interaction site; other site 561276010318 putative laminin-1 binding site; other site 561276010321 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 561276010322 Septum formation initiator; Region: DivIC; cl17659 561276010323 Surface antigen [General function prediction only]; Region: COG3942 561276010324 CHAP domain; Region: CHAP; pfam05257 561276010326 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 561276010328 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 561276010329 rod shape-determining protein MreC; Region: MreC; pfam04085 561276010331 1 transmembrane helix predicted for SPN23F22510 by TMHMM2.0 at aa 9-31 561276010332 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 561276010335 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13649 561276010336 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 561276010337 Walker A/P-loop; other site 561276010338 ATP binding site [chemical binding]; other site 561276010339 Q-loop/lid; other site 561276010340 ABC transporter signature motif; other site 561276010341 Walker B; other site 561276010342 D-loop; other site 561276010343 H-loop/switch region; other site 561276010347 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13650 561276010348 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 561276010349 Walker A/P-loop; other site 561276010350 ATP binding site [chemical binding]; other site 561276010351 Q-loop/lid; other site 561276010352 ABC transporter signature motif; other site 561276010353 Walker B; other site 561276010354 D-loop; other site 561276010355 H-loop/switch region; other site 561276010359 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 561276010362 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 561276010363 Helix-turn-helix domain; Region: HTH_25; pfam13413 561276010364 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 561276010365 1 transmembrane helix predicted for SPN23F22560 by TMHMM2.0 at aa 108-130 561276010366 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 561276010367 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 561276010368 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 561276010371 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 561276010372 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 561276010374 S4-like RNA binding protein [Replication, recombination, and repair]; Region: COG2501 561276010375 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 561276010376 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 561276010377 Walker A/P-loop; other site 561276010378 ATP binding site [chemical binding]; other site 561276010379 Q-loop/lid; other site 561276010380 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 561276010381 ABC transporter signature motif; other site 561276010382 Walker B; other site 561276010383 D-loop; other site 561276010384 H-loop/switch region; other site 561276010388 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 561276010389 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 561276010390 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 561276010391 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 561276010392 active site 561276010396 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 561276010397 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 561276010398 active site 561276010399 HIGH motif; other site 561276010400 dimer interface [polypeptide binding]; other site 561276010401 KMSKS motif; other site 561276010404 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 561276010405 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 561276010406 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 561276010407 ABC transporter; Region: ABC_tran_2; pfam12848 561276010408 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 561276010413 Predicted membrane protein [Function unknown]; Region: COG4485 561276010414 14 transmembrane helices predicted for SPN23F22640 by TMHMM2.0 at aa 11-33, 48-67, 74-96, 106-128,158-177, 190-212, 225-247, 287-309, 316-333, 348-370,377-396, 401-423, 430-452 and 819-841 561276010415 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 561276010416 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 561276010417 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 561276010418 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 561276010420 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 561276010421 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 561276010422 active site 561276010423 phosphorylation site [posttranslational modification] 561276010424 intermolecular recognition site; other site 561276010425 dimerization interface [polypeptide binding]; other site 561276010426 LytTr DNA-binding domain; Region: LytTR; pfam04397 561276010429 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 561276010430 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 561276010432 COMC family; Region: ComC; pfam03047 561276010434 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 561276010436 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 561276010437 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 561276010438 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 561276010439 protein binding site [polypeptide binding]; other site 561276010440 1 transmembrane helix predicted for SPN23F22720 by TMHMM2.0 at aa 12-34 561276010442 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 561276010443 ParB-like nuclease domain; Region: ParBc; pfam02195 561276010444 KorB domain; Region: KorB; pfam08535