-- dump date 20140620_084442 -- class Genbank::misc_feature -- table misc_feature_note -- id note 516950000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 516950000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 516950000003 Walker A motif; other site 516950000004 ATP binding site [chemical binding]; other site 516950000005 Walker B motif; other site 516950000006 arginine finger; other site 516950000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 516950000008 DnaA box-binding interface [nucleotide binding]; other site 516950000009 DNA polymerase III subunit beta; Validated; Region: PRK05643 516950000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 516950000011 putative DNA binding surface [nucleotide binding]; other site 516950000012 dimer interface [polypeptide binding]; other site 516950000013 beta-clamp/clamp loader binding surface; other site 516950000014 beta-clamp/translesion DNA polymerase binding surface; other site 516950000015 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4481 516950000016 GTP-binding protein YchF; Reviewed; Region: PRK09601 516950000017 YchF GTPase; Region: YchF; cd01900 516950000018 G1 box; other site 516950000019 GTP/Mg2+ binding site [chemical binding]; other site 516950000020 Switch I region; other site 516950000021 G2 box; other site 516950000022 Switch II region; other site 516950000023 G3 box; other site 516950000024 G4 box; other site 516950000025 G5 box; other site 516950000026 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 516950000027 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 516950000028 putative active site [active] 516950000029 catalytic residue [active] 516950000030 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 516950000031 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 516950000032 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 516950000033 ATP binding site [chemical binding]; other site 516950000034 putative Mg++ binding site [ion binding]; other site 516950000035 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 516950000036 nucleotide binding region [chemical binding]; other site 516950000037 ATP-binding site [chemical binding]; other site 516950000038 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 516950000039 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 516950000040 RNA binding surface [nucleotide binding]; other site 516950000041 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 516950000042 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 516950000043 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 516950000044 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 516950000045 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 516950000046 Ligand Binding Site [chemical binding]; other site 516950000047 TilS substrate C-terminal domain; Region: TilS_C; smart00977 516950000048 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 516950000049 active site 516950000050 ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465 516950000051 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 516950000052 Walker A motif; other site 516950000053 ATP binding site [chemical binding]; other site 516950000054 Walker B motif; other site 516950000055 arginine finger; other site 516950000056 Peptidase family M41; Region: Peptidase_M41; pfam01434 516950000057 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 516950000058 Helix-turn-helix domain; Region: HTH_28; pfam13518 516950000059 Winged helix-turn helix; Region: HTH_29; pfam13551 516950000060 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 516950000061 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 516950000062 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 516950000063 GDP-binding site [chemical binding]; other site 516950000064 ACT binding site; other site 516950000065 IMP binding site; other site 516950000066 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 516950000067 nucleoside/Zn binding site; other site 516950000068 dimer interface [polypeptide binding]; other site 516950000069 catalytic motif [active] 516950000070 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 516950000071 trimer interface [polypeptide binding]; other site 516950000072 active site 516950000073 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 516950000074 catalytic core [active] 516950000075 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 516950000076 DNA repair protein RadA; Provisional; Region: PRK11823 516950000077 Walker A motif; other site 516950000078 ATP binding site [chemical binding]; other site 516950000079 Walker B motif; other site 516950000080 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 516950000081 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379 516950000082 active site clefts [active] 516950000083 zinc binding site [ion binding]; other site 516950000084 dimer interface [polypeptide binding]; other site 516950000085 Protease prsW family; Region: PrsW-protease; cl15823 516950000086 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 516950000087 Helix-turn-helix domain; Region: HTH_38; pfam13936 516950000088 putative transposase OrfB; Reviewed; Region: PHA02517 516950000089 HTH-like domain; Region: HTH_21; pfam13276 516950000090 Integrase core domain; Region: rve; pfam00665 516950000091 Integrase core domain; Region: rve_2; pfam13333 516950000092 Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339 516950000093 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269 516950000094 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 516950000095 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 516950000096 active site 516950000097 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 516950000098 DNA polymerase I; Provisional; Region: PRK05755 516950000099 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 516950000100 active site 516950000101 metal binding site 1 [ion binding]; metal-binding site 516950000102 putative 5' ssDNA interaction site; other site 516950000103 metal binding site 3; metal-binding site 516950000104 metal binding site 2 [ion binding]; metal-binding site 516950000105 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 516950000106 putative DNA binding site [nucleotide binding]; other site 516950000107 putative metal binding site [ion binding]; other site 516950000108 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 516950000109 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 516950000110 active site 516950000111 DNA binding site [nucleotide binding] 516950000112 catalytic site [active] 516950000113 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 516950000114 Predicted membrane protein [Function unknown]; Region: COG2855 516950000115 aromatic amino acid aminotransferase; Validated; Region: PRK07309 516950000116 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 516950000117 pyridoxal 5'-phosphate binding site [chemical binding]; other site 516950000118 homodimer interface [polypeptide binding]; other site 516950000119 catalytic residue [active] 516950000120 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381 516950000121 Recombination protein O N terminal; Region: RecO_N; pfam11967 516950000122 Recombination protein O C terminal; Region: RecO_C; pfam02565 516950000123 putative phosphate acyltransferase; Provisional; Region: PRK05331 516950000124 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 516950000125 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 516950000126 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 516950000127 putative active site [active] 516950000128 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 516950000129 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 516950000130 Walker A/P-loop; other site 516950000131 ATP binding site [chemical binding]; other site 516950000132 Q-loop/lid; other site 516950000133 ABC transporter signature motif; other site 516950000134 Walker B; other site 516950000135 D-loop; other site 516950000136 H-loop/switch region; other site 516950000137 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 516950000138 HlyD family secretion protein; Region: HlyD_3; pfam13437 516950000139 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 516950000140 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 516950000141 ATP binding site [chemical binding]; other site 516950000142 active site 516950000143 substrate binding site [chemical binding]; other site 516950000144 phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857 516950000145 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 516950000146 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 516950000147 dimerization interface [polypeptide binding]; other site 516950000148 ATP binding site [chemical binding]; other site 516950000149 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 516950000150 dimerization interface [polypeptide binding]; other site 516950000151 ATP binding site [chemical binding]; other site 516950000152 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 516950000153 putative active site [active] 516950000154 catalytic triad [active] 516950000155 amidophosphoribosyltransferase; Provisional; Region: PRK07272 516950000156 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 516950000157 active site 516950000158 tetramer interface [polypeptide binding]; other site 516950000159 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 516950000160 active site 516950000161 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 516950000162 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 516950000163 dimerization interface [polypeptide binding]; other site 516950000164 putative ATP binding site [chemical binding]; other site 516950000165 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 516950000166 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 516950000167 active site 516950000168 substrate binding site [chemical binding]; other site 516950000169 cosubstrate binding site; other site 516950000170 catalytic site [active] 516950000171 VanZ like family; Region: VanZ; pfam04892 516950000172 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 516950000173 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 516950000174 purine monophosphate binding site [chemical binding]; other site 516950000175 dimer interface [polypeptide binding]; other site 516950000176 putative catalytic residues [active] 516950000177 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 516950000178 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 516950000179 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 516950000180 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 516950000181 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 516950000182 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 516950000183 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 516950000184 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 516950000185 ATP-grasp domain; Region: ATP-grasp; pfam02222 516950000186 adenylosuccinate lyase; Provisional; Region: PRK07492 516950000187 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 516950000188 tetramer interface [polypeptide binding]; other site 516950000189 active site 516950000190 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 516950000191 N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525 516950000192 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 516950000193 active site 516950000194 Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564 516950000195 active site 516950000196 G5 domain; Region: G5; pfam07501 516950000197 G5 domain; Region: G5; pfam07501 516950000198 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 516950000199 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 516950000200 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 516950000201 DNA-binding site [nucleotide binding]; DNA binding site 516950000202 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 516950000203 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 516950000204 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 516950000205 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 516950000206 active site 516950000207 phosphorylation site [posttranslational modification] 516950000208 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 516950000209 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 516950000210 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 516950000211 active pocket/dimerization site; other site 516950000212 active site 516950000213 phosphorylation site [posttranslational modification] 516950000214 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 516950000215 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 516950000216 dimer interface [polypeptide binding]; other site 516950000217 active site 516950000218 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 516950000219 putative active site [active] 516950000220 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 516950000221 active site 516950000222 catalytic residues [active] 516950000223 Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514 516950000224 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255 516950000225 putative metal binding site [ion binding]; other site 516950000226 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 516950000227 active site 516950000228 Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155 516950000229 putative homodimer interface [polypeptide binding]; other site 516950000230 putative homotetramer interface [polypeptide binding]; other site 516950000231 putative metal binding site [ion binding]; other site 516950000232 putative homodimer-homodimer interface [polypeptide binding]; other site 516950000233 putative allosteric switch controlling residues; other site 516950000234 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 516950000235 active site residue [active] 516950000236 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 516950000237 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 516950000238 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 516950000239 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 516950000240 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 516950000241 TrkA-N domain; Region: TrkA_N; pfam02254 516950000242 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 516950000243 active site 516950000244 Fibronectin-binding repeat; Region: SSURE; pfam11966 516950000245 Fibronectin-binding repeat; Region: SSURE; pfam11966 516950000246 Fibronectin-binding repeat; Region: SSURE; pfam11966 516950000247 Fibronectin-binding repeat; Region: SSURE; pfam11966 516950000248 Fibronectin-binding repeat; Region: SSURE; pfam11966 516950000249 Fibronectin-binding repeat; Region: SSURE; pfam11966 516950000250 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 516950000251 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 516950000252 active site 516950000253 phosphorylation site [posttranslational modification] 516950000254 intermolecular recognition site; other site 516950000255 dimerization interface [polypeptide binding]; other site 516950000256 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 516950000257 DNA binding site [nucleotide binding] 516950000258 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 516950000259 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 516950000260 dimerization interface [polypeptide binding]; other site 516950000261 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 516950000262 dimer interface [polypeptide binding]; other site 516950000263 phosphorylation site [posttranslational modification] 516950000264 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 516950000265 ATP binding site [chemical binding]; other site 516950000266 Mg2+ binding site [ion binding]; other site 516950000267 G-X-G motif; other site 516950000268 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 516950000269 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 516950000270 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 516950000271 RNA binding surface [nucleotide binding]; other site 516950000272 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 516950000273 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 516950000274 dimer interface [polypeptide binding]; other site 516950000275 conserved gate region; other site 516950000276 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 516950000277 ABC-ATPase subunit interface; other site 516950000278 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 516950000279 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 516950000280 dimer interface [polypeptide binding]; other site 516950000281 conserved gate region; other site 516950000282 putative PBP binding loops; other site 516950000283 ABC-ATPase subunit interface; other site 516950000284 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 516950000285 Domain of unknown function (DUF3502); Region: DUF3502; pfam12010 516950000286 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 516950000287 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 516950000288 active site residue [active] 516950000289 Protein of unknown function (DUF3650); Region: DUF3650; pfam12368 516950000290 Domain of unknown function (DUF4299); Region: DUF4299; pfam14132 516950000291 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 516950000292 Predicted membrane protein [Function unknown]; Region: COG4709 516950000293 Predicted transcriptional regulators [Transcription]; Region: COG1695 516950000294 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 516950000295 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 516950000296 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 516950000297 putative substrate translocation pore; other site 516950000298 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 516950000299 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 516950000300 Ligand binding site; other site 516950000301 Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086 516950000302 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 516950000303 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 516950000304 NAD(P) binding site [chemical binding]; other site 516950000305 homodimer interface [polypeptide binding]; other site 516950000306 substrate binding site [chemical binding]; other site 516950000307 active site 516950000308 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 516950000309 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 516950000310 active site 516950000311 motif I; other site 516950000312 motif II; other site 516950000313 Serine dehydratase alpha chain; Region: SDH_alpha; cl12120 516950000314 L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760 516950000315 L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719 516950000316 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 516950000317 C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903 516950000318 putative L-serine binding site [chemical binding]; other site 516950000319 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 516950000320 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 516950000321 bacteriocin, lactococcin 972 family; Region: lactococcin_972; TIGR01653 516950000322 bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654 516950000323 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 516950000324 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 516950000325 Walker A/P-loop; other site 516950000326 ATP binding site [chemical binding]; other site 516950000327 Q-loop/lid; other site 516950000328 ABC transporter signature motif; other site 516950000329 Walker B; other site 516950000330 D-loop; other site 516950000331 H-loop/switch region; other site 516950000332 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 516950000333 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 516950000334 substrate binding pocket [chemical binding]; other site 516950000335 membrane-bound complex binding site; other site 516950000336 hinge residues; other site 516950000337 Arginosuccinate synthase; Region: Arginosuc_synth; cl17227 516950000338 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 516950000339 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 516950000340 non-specific DNA binding site [nucleotide binding]; other site 516950000341 salt bridge; other site 516950000342 sequence-specific DNA binding site [nucleotide binding]; other site 516950000343 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 516950000344 putative active site [active] 516950000345 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 516950000346 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 516950000347 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 516950000348 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 516950000349 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 516950000350 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 516950000351 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 516950000352 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 516950000353 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 516950000354 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688 516950000355 nudix motif; other site 516950000356 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 516950000357 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 516950000358 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 516950000359 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 516950000360 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 516950000361 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 516950000362 hypothetical protein; Provisional; Region: PRK13667 516950000363 class IIb bacteriocin, lactobin A/cerein 7B family; Region: bact_IIb_cerein; TIGR03949 516950000364 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 516950000365 Glycoprotease family; Region: Peptidase_M22; pfam00814 516950000366 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 516950000367 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 516950000368 Coenzyme A binding pocket [chemical binding]; other site 516950000369 UGMP family protein; Validated; Region: PRK09604 516950000370 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 516950000371 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 516950000372 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 516950000373 Transposase; Region: DDE_Tnp_ISL3; pfam01610 516950000374 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 516950000375 Helix-turn-helix domain; Region: HTH_38; pfam13936 516950000376 Transposase; Region: DDE_Tnp_ISL3; pfam01610 516950000377 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 516950000378 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 516950000379 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 516950000380 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 516950000381 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 516950000382 active site 516950000383 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 516950000384 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 516950000385 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 516950000386 Walker A/P-loop; other site 516950000387 ATP binding site [chemical binding]; other site 516950000388 Q-loop/lid; other site 516950000389 ABC transporter signature motif; other site 516950000390 Walker B; other site 516950000391 D-loop; other site 516950000392 H-loop/switch region; other site 516950000393 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 516950000394 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 516950000395 Ligand Binding Site [chemical binding]; other site 516950000396 Molecular Tunnel; other site 516950000397 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 516950000398 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 516950000399 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 516950000400 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 516950000401 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 516950000402 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 516950000403 non-specific DNA binding site [nucleotide binding]; other site 516950000404 salt bridge; other site 516950000405 sequence-specific DNA binding site [nucleotide binding]; other site 516950000406 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 516950000407 Lantibiotic dehydratase, C terminus; Region: Lant_dehyd_C; pfam04738 516950000408 thiopeptide-type bacteriocin biosynthesis domain; Region: thiopep_ocin; TIGR03891 516950000409 LanC is the cyclase enzyme of the lanthionine synthetase. Lanthinoine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as precursor peptides and then post-translationally modified to contain thioether cross-links...; Region: LanC; cd04793 516950000410 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 516950000411 active site 516950000412 zinc binding site [ion binding]; other site 516950000413 H+ Antiporter protein; Region: 2A0121; TIGR00900 516950000414 CAAX protease self-immunity; Region: Abi; pfam02517 516950000415 CAAX protease self-immunity; Region: Abi; pfam02517 516950000416 AzlC protein; Region: AzlC; cl00570 516950000417 Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735 516950000418 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 516950000419 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 516950000420 substrate binding pocket [chemical binding]; other site 516950000421 membrane-bound complex binding site; other site 516950000422 hinge residues; other site 516950000423 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 516950000424 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 516950000425 hypothetical protein; Provisional; Region: PRK06446 516950000426 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681 516950000427 metal binding site [ion binding]; metal-binding site 516950000428 dimer interface [polypeptide binding]; other site 516950000429 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 516950000430 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 516950000431 Walker A/P-loop; other site 516950000432 ATP binding site [chemical binding]; other site 516950000433 Q-loop/lid; other site 516950000434 ABC transporter signature motif; other site 516950000435 Walker B; other site 516950000436 D-loop; other site 516950000437 H-loop/switch region; other site 516950000438 NIL domain; Region: NIL; pfam09383 516950000439 ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011 516950000440 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 516950000441 non-specific DNA binding site [nucleotide binding]; other site 516950000442 salt bridge; other site 516950000443 sequence-specific DNA binding site [nucleotide binding]; other site 516950000444 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 516950000445 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 516950000446 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 516950000447 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 516950000448 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 516950000449 Walker A motif; other site 516950000450 ATP binding site [chemical binding]; other site 516950000451 Walker B motif; other site 516950000452 arginine finger; other site 516950000453 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 516950000454 non-specific DNA binding site [nucleotide binding]; other site 516950000455 salt bridge; other site 516950000456 sequence-specific DNA binding site [nucleotide binding]; other site 516950000457 Replication initiation factor; Region: Rep_trans; pfam02486 516950000458 Antirestriction protein (ArdA); Region: ArdA; pfam07275 516950000459 TcpE family; Region: TcpE; pfam12648 516950000460 AAA-like domain; Region: AAA_10; pfam12846 516950000461 ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346 516950000462 Haemolysin-III related; Region: HlyIII; cl03831 516950000463 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 516950000464 N-acetyl-D-glucosamine binding site [chemical binding]; other site 516950000465 catalytic residue [active] 516950000466 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 516950000467 NlpC/P60 family; Region: NLPC_P60; pfam00877 516950000468 Conjugative transposon protein TcpC; Region: TpcC; pfam12642 516950000469 tetracycline resistance determinant leader peptide; Provisional; Region: PRK14751 516950000470 Translation elongation factors (GTPases) [Translation, ribosomal structure and biogenesis]; Region: FusA; COG0480 516950000471 Tet(M)-like family includes Tet(M), Tet(O), Tet(W), and OtrA, containing tetracycline resistant proteins; Region: TetM_like; cd04168 516950000472 G1 box; other site 516950000473 putative GEF interaction site [polypeptide binding]; other site 516950000474 GTP/Mg2+ binding site [chemical binding]; other site 516950000475 Switch I region; other site 516950000476 G2 box; other site 516950000477 G3 box; other site 516950000478 Switch II region; other site 516950000479 G4 box; other site 516950000480 G5 box; other site 516950000481 Tet_II: This subfamily represents domain II of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to domain II of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome...; Region: Tet_II; cd03690 516950000482 EF-G_domain IV_RPP domain is a part of bacterial ribosomal protected proteins (RPP) family. RPPs such as tetracycline resistance proteins Tet(M) and Tet(O) mediate tetracycline resistance in both gram-positive and -negative species. Tetracyclines inhibit...; Region: Tet_like_IV; cd01684 516950000483 Tet_C: C-terminus of ribosomal protection proteins Tet(M) and Tet(O). This domain has homology to the C terminal domains of the elongation factors EF-G and EF-2. Tet(M) and Tet(O) catalyze the release of tetracycline (Tc) from the ribosome in a...; Region: Tet_C; cd03711 516950000484 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 516950000485 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 516950000486 S-adenosylmethionine binding site [chemical binding]; other site 516950000487 multiple promoter invertase; Provisional; Region: mpi; PRK13413 516950000488 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 516950000489 catalytic residues [active] 516950000490 catalytic nucleophile [active] 516950000491 Presynaptic Site I dimer interface [polypeptide binding]; other site 516950000492 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 516950000493 Synaptic Flat tetramer interface [polypeptide binding]; other site 516950000494 Synaptic Site I dimer interface [polypeptide binding]; other site 516950000495 DNA binding site [nucleotide binding] 516950000496 Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796 516950000497 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 516950000498 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 516950000499 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 516950000500 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 516950000501 non-specific DNA binding site [nucleotide binding]; other site 516950000502 salt bridge; other site 516950000503 sequence-specific DNA binding site [nucleotide binding]; other site 516950000504 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 516950000505 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 516950000506 DNA binding residues [nucleotide binding] 516950000507 Helix-turn-helix domain; Region: HTH_16; pfam12645 516950000508 Excisionase from transposon Tn916; Region: Tn916-Xis; pfam09035 516950000509 DNA binding domain of tn916 integrase; Region: Integrase_DNA; pfam02920 516950000510 Tn1545-related conjugative transposon integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes bacterial (gram positive) and phage integrases, including those similar to Tn1545, Tn5252, and...; Region: INT_Tn1545_C; cd01199 516950000511 Int/Topo IB signature motif; other site 516950000512 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 516950000513 flavoprotein NrdI; Provisional; Region: PRK02551 516950000514 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 516950000515 Protein of unknown function (DUF3021); Region: DUF3021; pfam11457 516950000516 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 516950000517 LytTr DNA-binding domain; Region: LytTR; smart00850 516950000518 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 516950000519 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 516950000520 ATP binding site [chemical binding]; other site 516950000521 Mg2+ binding site [ion binding]; other site 516950000522 G-X-G motif; other site 516950000523 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 516950000524 ATP binding site [chemical binding]; other site 516950000525 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 516950000526 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 516950000527 homopentamer interface [polypeptide binding]; other site 516950000528 active site 516950000529 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 516950000530 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 516950000531 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 516950000532 dimerization interface [polypeptide binding]; other site 516950000533 active site 516950000534 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 516950000535 Lumazine binding domain; Region: Lum_binding; pfam00677 516950000536 Lumazine binding domain; Region: Lum_binding; pfam00677 516950000537 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 516950000538 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 516950000539 catalytic motif [active] 516950000540 Zn binding site [ion binding]; other site 516950000541 RibD C-terminal domain; Region: RibD_C; cl17279 516950000542 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 516950000543 RuvA N terminal domain; Region: RuvA_N; pfam01330 516950000544 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 516950000545 CAAX protease self-immunity; Region: Abi; pfam02517 516950000546 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 516950000547 putative dimer interface [polypeptide binding]; other site 516950000548 catalytic triad [active] 516950000549 Protein of unknown function (DUF1129); Region: DUF1129; cl11555 516950000550 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 516950000551 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 516950000552 Cl binding site [ion binding]; other site 516950000553 oligomer interface [polypeptide binding]; other site 516950000554 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 516950000555 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 516950000556 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 516950000557 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 516950000558 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 516950000559 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 516950000560 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 516950000561 active site 516950000562 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 516950000563 ArsC family; Region: ArsC; pfam03960 516950000564 putative catalytic residues [active] 516950000565 thiol/disulfide switch; other site 516950000566 hypothetical protein; Provisional; Region: PRK05473 516950000567 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 516950000568 hypothetical protein; Provisional; Region: PRK13678 516950000569 folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499 516950000570 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 516950000571 Bacterial lipoprotein; Region: DUF3642; pfam12182 516950000572 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 516950000573 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 516950000574 Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154 516950000575 putative active site [active] 516950000576 catalytic site [active] 516950000577 Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160 516950000578 putative active site [active] 516950000579 catalytic site [active] 516950000580 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 516950000581 ATP cone domain; Region: ATP-cone; pfam03477 516950000582 Class III ribonucleotide reductase; Region: RNR_III; cd01675 516950000583 effector binding site; other site 516950000584 active site 516950000585 Zn binding site [ion binding]; other site 516950000586 glycine loop; other site 516950000587 Predicted acetyltransferase [General function prediction only]; Region: COG3981 516950000588 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 516950000589 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 516950000590 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 516950000591 FeS/SAM binding site; other site 516950000592 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 516950000593 active site 516950000594 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 516950000595 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 516950000596 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 516950000597 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 516950000598 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 516950000599 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 516950000600 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 516950000601 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 516950000602 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 516950000603 putative translocon binding site; other site 516950000604 protein-rRNA interface [nucleotide binding]; other site 516950000605 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 516950000606 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 516950000607 G-X-X-G motif; other site 516950000608 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 516950000609 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 516950000610 23S rRNA interface [nucleotide binding]; other site 516950000611 5S rRNA interface [nucleotide binding]; other site 516950000612 putative antibiotic binding site [chemical binding]; other site 516950000613 L25 interface [polypeptide binding]; other site 516950000614 L27 interface [polypeptide binding]; other site 516950000615 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 516950000616 23S rRNA interface [nucleotide binding]; other site 516950000617 putative translocon interaction site; other site 516950000618 signal recognition particle (SRP54) interaction site; other site 516950000619 L23 interface [polypeptide binding]; other site 516950000620 trigger factor interaction site; other site 516950000621 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 516950000622 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 516950000623 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 516950000624 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 516950000625 RNA binding site [nucleotide binding]; other site 516950000626 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 516950000627 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 516950000628 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 516950000629 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 516950000630 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 516950000631 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 516950000632 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 516950000633 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 516950000634 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 516950000635 5S rRNA interface [nucleotide binding]; other site 516950000636 L27 interface [polypeptide binding]; other site 516950000637 23S rRNA interface [nucleotide binding]; other site 516950000638 L5 interface [polypeptide binding]; other site 516950000639 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 516950000640 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 516950000641 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 516950000642 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 516950000643 23S rRNA binding site [nucleotide binding]; other site 516950000644 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 516950000645 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 516950000646 SecY translocase; Region: SecY; pfam00344 516950000647 adenylate kinase; Reviewed; Region: adk; PRK00279 516950000648 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 516950000649 AMP-binding site [chemical binding]; other site 516950000650 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 516950000651 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 516950000652 rRNA binding site [nucleotide binding]; other site 516950000653 predicted 30S ribosome binding site; other site 516950000654 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 516950000655 30S ribosomal protein S13; Region: bact_S13; TIGR03631 516950000656 30S ribosomal protein S11; Validated; Region: PRK05309 516950000657 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 516950000658 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 516950000659 alphaNTD homodimer interface [polypeptide binding]; other site 516950000660 alphaNTD - beta interaction site [polypeptide binding]; other site 516950000661 alphaNTD - beta' interaction site [polypeptide binding]; other site 516950000662 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 516950000663 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 516950000664 ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872 516950000665 Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025 516950000666 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 516950000667 catalytic core [active] 516950000668 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 516950000669 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 516950000670 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 516950000671 dimer interface [polypeptide binding]; other site 516950000672 conserved gate region; other site 516950000673 putative PBP binding loops; other site 516950000674 ABC-ATPase subunit interface; other site 516950000675 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 516950000676 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 516950000677 dimer interface [polypeptide binding]; other site 516950000678 conserved gate region; other site 516950000679 ABC-ATPase subunit interface; other site 516950000680 TOBE domain; Region: TOBE_2; pfam08402 516950000681 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 516950000682 thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277 516950000683 Walker A/P-loop; other site 516950000684 ATP binding site [chemical binding]; other site 516950000685 Q-loop/lid; other site 516950000686 ABC transporter signature motif; other site 516950000687 Walker B; other site 516950000688 D-loop; other site 516950000689 H-loop/switch region; other site 516950000690 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 516950000691 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 516950000692 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 516950000693 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 516950000694 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 516950000695 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 516950000696 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 516950000697 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 516950000698 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 516950000699 active site 516950000700 methionine cluster; other site 516950000701 phosphorylation site [posttranslational modification] 516950000702 metal binding site [ion binding]; metal-binding site 516950000703 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 516950000704 active site 516950000705 P-loop; other site 516950000706 phosphorylation site [posttranslational modification] 516950000707 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 516950000708 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 516950000709 Pyruvate-formate lyase [Energy production and conversion]; Region: PflD; COG1882 516950000710 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 516950000711 dimer interface [polypeptide binding]; other site 516950000712 active site 516950000713 glycine loop; other site 516950000714 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 516950000715 active site 516950000716 intersubunit interactions; other site 516950000717 catalytic residue [active] 516950000718 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 516950000719 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 516950000720 dimer interface [polypeptide binding]; other site 516950000721 active site 516950000722 metal binding site [ion binding]; metal-binding site 516950000723 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 516950000724 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 516950000725 HIGH motif; other site 516950000726 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 516950000727 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 516950000728 active site 516950000729 KMSKS motif; other site 516950000730 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 516950000731 tRNA binding surface [nucleotide binding]; other site 516950000732 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 516950000733 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 516950000734 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 516950000735 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 516950000736 Coenzyme A binding pocket [chemical binding]; other site 516950000737 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 516950000738 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 516950000739 Walker A motif; other site 516950000740 ATP binding site [chemical binding]; other site 516950000741 Walker B motif; other site 516950000742 arginine finger; other site 516950000743 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 516950000744 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3575 516950000745 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 516950000746 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 516950000747 catalytic residue [active] 516950000748 putative FPP diphosphate binding site; other site 516950000749 putative FPP binding hydrophobic cleft; other site 516950000750 dimer interface [polypeptide binding]; other site 516950000751 putative IPP diphosphate binding site; other site 516950000752 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 516950000753 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 516950000754 RIP metalloprotease RseP; Region: TIGR00054 516950000755 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 516950000756 active site 516950000757 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 516950000758 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 516950000759 putative substrate binding region [chemical binding]; other site 516950000760 prolyl-tRNA synthetase; Provisional; Region: PRK09194 516950000761 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 516950000762 dimer interface [polypeptide binding]; other site 516950000763 motif 1; other site 516950000764 active site 516950000765 motif 2; other site 516950000766 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 516950000767 putative deacylase active site [active] 516950000768 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 516950000769 active site 516950000770 motif 3; other site 516950000771 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 516950000772 anticodon binding site; other site 516950000773 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 516950000774 beta-galactosidase; Region: BGL; TIGR03356 516950000775 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 516950000776 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 516950000777 glutaminase active site [active] 516950000778 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 516950000779 dimer interface [polypeptide binding]; other site 516950000780 active site 516950000781 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 516950000782 dimer interface [polypeptide binding]; other site 516950000783 active site 516950000784 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 516950000785 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 516950000786 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 516950000787 pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102 516950000788 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 516950000789 carbohydrate binding site [chemical binding]; other site 516950000790 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315 516950000791 carbohydrate binding site [chemical binding]; other site 516950000792 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 516950000793 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 516950000794 Ca binding site [ion binding]; other site 516950000795 active site 516950000796 catalytic site [active] 516950000797 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 516950000798 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 516950000799 S17 interaction site [polypeptide binding]; other site 516950000800 S8 interaction site; other site 516950000801 16S rRNA interaction site [nucleotide binding]; other site 516950000802 streptomycin interaction site [chemical binding]; other site 516950000803 23S rRNA interaction site [nucleotide binding]; other site 516950000804 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 516950000805 30S ribosomal protein S7; Validated; Region: PRK05302 516950000806 elongation factor G; Reviewed; Region: PRK00007 516950000807 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 516950000808 G1 box; other site 516950000809 putative GEF interaction site [polypeptide binding]; other site 516950000810 GTP/Mg2+ binding site [chemical binding]; other site 516950000811 Switch I region; other site 516950000812 G2 box; other site 516950000813 G3 box; other site 516950000814 Switch II region; other site 516950000815 G4 box; other site 516950000816 G5 box; other site 516950000817 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 516950000818 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 516950000819 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 516950000820 DNA polymerase III PolC; Validated; Region: polC; PRK00448 516950000821 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 516950000822 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 516950000823 generic binding surface II; other site 516950000824 generic binding surface I; other site 516950000825 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 516950000826 active site 516950000827 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 516950000828 active site 516950000829 catalytic site [active] 516950000830 substrate binding site [chemical binding]; other site 516950000831 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 516950000832 putative PHP Thumb interface [polypeptide binding]; other site 516950000833 active site 516950000834 addiction module antitoxin, RelB/DinJ family; Region: RelB_DinJ; TIGR02384 516950000835 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 516950000836 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 516950000837 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 516950000838 Predicted membrane protein [Function unknown]; Region: COG2261 516950000839 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 516950000840 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 516950000841 RNA binding surface [nucleotide binding]; other site 516950000842 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 516950000843 active site 516950000844 uracil binding [chemical binding]; other site 516950000845 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 516950000846 trimer interface [polypeptide binding]; other site 516950000847 active site 516950000848 G bulge; other site 516950000849 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 516950000850 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 516950000851 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 516950000852 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 516950000853 active pocket/dimerization site; other site 516950000854 active site 516950000855 phosphorylation site [posttranslational modification] 516950000856 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 516950000857 active site 516950000858 phosphorylation site [posttranslational modification] 516950000859 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 516950000860 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 516950000861 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 516950000862 NAD binding site [chemical binding]; other site 516950000863 substrate binding site [chemical binding]; other site 516950000864 catalytic Zn binding site [ion binding]; other site 516950000865 tetramer interface [polypeptide binding]; other site 516950000866 structural Zn binding site [ion binding]; other site 516950000867 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 516950000868 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 516950000869 active site 516950000870 motif I; other site 516950000871 motif II; other site 516950000872 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 516950000873 Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266 516950000874 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 516950000875 dihydropteroate synthase; Region: DHPS; TIGR01496 516950000876 substrate binding pocket [chemical binding]; other site 516950000877 dimer interface [polypeptide binding]; other site 516950000878 inhibitor binding site; inhibition site 516950000879 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 516950000880 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 516950000881 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 516950000882 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 516950000883 homodecamer interface [polypeptide binding]; other site 516950000884 GTP cyclohydrolase I; Provisional; Region: PLN03044 516950000885 active site 516950000886 putative catalytic site residues [active] 516950000887 zinc binding site [ion binding]; other site 516950000888 GTP-CH-I/GFRP interaction surface; other site 516950000889 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 516950000890 homooctamer interface [polypeptide binding]; other site 516950000891 active site 516950000892 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 516950000893 catalytic center binding site [active] 516950000894 ATP binding site [chemical binding]; other site 516950000895 Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124 516950000896 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 516950000897 23S rRNA interface [nucleotide binding]; other site 516950000898 L3 interface [polypeptide binding]; other site 516950000899 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 516950000900 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 516950000901 Uncharacterized conserved protein [Function unknown]; Region: COG1359 516950000902 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 516950000903 beta-galactosidase; Region: BGL; TIGR03356 516950000904 Uncharacterized conserved protein [Function unknown]; Region: COG4095 516950000905 cellobiose phosphotransferase system IIB component; Reviewed; Region: celB; PRK09590 516950000906 active site 516950000907 P-loop; other site 516950000908 phosphorylation site [posttranslational modification] 516950000909 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 516950000910 HTH domain; Region: HTH_11; pfam08279 516950000911 Mga helix-turn-helix domain; Region: Mga; pfam05043 516950000912 PRD domain; Region: PRD; pfam00874 516950000913 PRD domain; Region: PRD; pfam00874 516950000914 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 516950000915 active site 516950000916 P-loop; other site 516950000917 phosphorylation site [posttranslational modification] 516950000918 Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: PtsN; COG1762 516950000919 active site 516950000920 phosphorylation site [posttranslational modification] 516950000921 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 516950000922 methionine cluster; other site 516950000923 active site 516950000924 phosphorylation site [posttranslational modification] 516950000925 metal binding site [ion binding]; metal-binding site 516950000926 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 516950000927 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 516950000928 Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501 516950000929 This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595 516950000930 putative active site [active] 516950000931 putative catalytic site [active] 516950000932 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 516950000933 catalytic residues [active] 516950000934 dimer interface [polypeptide binding]; other site 516950000935 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 516950000936 Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083 516950000937 substrate binding site [chemical binding]; other site 516950000938 catalytic residues [active] 516950000939 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 516950000940 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 516950000941 active site 516950000942 intersubunit interface [polypeptide binding]; other site 516950000943 catalytic residue [active] 516950000944 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 516950000945 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 516950000946 substrate binding site [chemical binding]; other site 516950000947 ATP binding site [chemical binding]; other site 516950000948 hypothetical protein; Provisional; Region: PRK09273 516950000949 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 516950000950 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 516950000951 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 516950000952 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 516950000953 NADP binding site [chemical binding]; other site 516950000954 homodimer interface [polypeptide binding]; other site 516950000955 active site 516950000956 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 516950000957 active pocket/dimerization site; other site 516950000958 active site 516950000959 phosphorylation site [posttranslational modification] 516950000960 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 516950000961 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 516950000962 active site 516950000963 phosphorylation site [posttranslational modification] 516950000964 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 516950000965 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 516950000966 Preprotein translocase subunit YajC [Intracellular trafficking and secretion]; Region: YajC; COG1862 516950000967 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 516950000968 Transcriptional regulators [Transcription]; Region: PurR; COG1609 516950000969 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 516950000970 DNA binding site [nucleotide binding] 516950000971 domain linker motif; other site 516950000972 Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283 516950000973 putative dimerization interface [polypeptide binding]; other site 516950000974 putative ligand binding site [chemical binding]; other site 516950000975 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 516950000976 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 516950000977 non-specific DNA binding site [nucleotide binding]; other site 516950000978 salt bridge; other site 516950000979 sequence-specific DNA binding site [nucleotide binding]; other site 516950000980 Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275 516950000981 MraW methylase family; Region: Methyltransf_5; pfam01795 516950000982 Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839 516950000983 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 516950000984 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 516950000985 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 516950000986 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 516950000987 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 516950000988 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 516950000989 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 516950000990 Mg++ binding site [ion binding]; other site 516950000991 putative catalytic motif [active] 516950000992 putative substrate binding site [chemical binding]; other site 516950000993 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 516950000994 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 516950000995 Walker A motif; other site 516950000996 ATP binding site [chemical binding]; other site 516950000997 Walker B motif; other site 516950000998 arginine finger; other site 516950000999 UvrB/uvrC motif; Region: UVR; pfam02151 516950001000 MoxR-like ATPases [General function prediction only]; Region: COG0714 516950001001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 516950001002 Walker A motif; other site 516950001003 ATP binding site [chemical binding]; other site 516950001004 Walker B motif; other site 516950001005 arginine finger; other site 516950001006 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 516950001007 LuxS protein involved in autoinducer AI2 synthesis [Signal transduction mechanisms]; Region: LuxS; COG1854 516950001008 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868 516950001009 hypothetical protein; Provisional; Region: PRK13663 516950001010 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 516950001011 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 516950001012 Ca binding site [ion binding]; other site 516950001013 active site 516950001014 catalytic site [active] 516950001015 DNA polymerase processivity factor; Region: DNA_PPF; pfam02916 516950001016 Transcriptional regulator [Transcription]; Region: LytR; COG1316 516950001017 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 516950001018 polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006 516950001019 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 516950001020 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 516950001021 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 516950001022 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 516950001023 Bacterial sugar transferase; Region: Bac_transf; pfam02397 516950001024 Oligosaccharide biosynthesis protein Alg14 like; Region: Alg14; pfam08660 516950001025 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; pfam04101 516950001026 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 516950001027 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 516950001028 active site 516950001029 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 516950001030 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 516950001031 active site 516950001032 Capsular polysaccharide synthesis protein; Region: Caps_synth; pfam05704 516950001033 WavE lipopolysaccharide synthesis; Region: WavE; pfam07507 516950001034 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 516950001035 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 516950001036 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 516950001037 Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222 516950001038 domain interaction interfaces [polypeptide binding]; other site 516950001039 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 516950001040 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 516950001041 Transposase; Region: DDE_Tnp_ISL3; pfam01610 516950001042 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 516950001043 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 516950001044 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 516950001045 peptide binding site [polypeptide binding]; other site 516950001046 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 516950001047 Endo-alpha-N-acetylgalactosaminidase; Region: Glyco_hydro_101; pfam12905 516950001048 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 516950001049 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 516950001050 Transglycosylase; Region: Transgly; pfam00912 516950001051 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 516950001052 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 516950001053 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 516950001054 hypothetical protein; Provisional; Region: PRK13660 516950001055 cell division protein GpsB; Provisional; Region: PRK14127 516950001056 DivIVA domain; Region: DivI1A_domain; TIGR03544 516950001057 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 516950001058 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 516950001059 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 516950001060 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 516950001061 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 516950001062 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 516950001063 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 516950001064 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 516950001065 active site 516950001066 phosphorylation site [posttranslational modification] 516950001067 intermolecular recognition site; other site 516950001068 dimerization interface [polypeptide binding]; other site 516950001069 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 516950001070 DNA binding site [nucleotide binding] 516950001071 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 516950001072 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955 516950001073 active site 516950001074 zinc binding site [ion binding]; other site 516950001075 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 516950001076 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 516950001077 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 516950001078 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 516950001079 diphosphomevalonate decarboxylase; Region: PLN02407 516950001080 Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577 516950001081 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 516950001082 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 516950001083 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 516950001084 homotetramer interface [polypeptide binding]; other site 516950001085 FMN binding site [chemical binding]; other site 516950001086 homodimer contacts [polypeptide binding]; other site 516950001087 putative active site [active] 516950001088 putative substrate binding site [chemical binding]; other site 516950001089 Predicted membrane protein [Function unknown]; Region: COG4758 516950001090 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 516950001091 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 516950001092 Histidine kinase; Region: HisKA_3; pfam07730 516950001093 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 516950001094 ATP binding site [chemical binding]; other site 516950001095 Mg2+ binding site [ion binding]; other site 516950001096 G-X-G motif; other site 516950001097 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 516950001098 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 516950001099 active site 516950001100 phosphorylation site [posttranslational modification] 516950001101 intermolecular recognition site; other site 516950001102 dimerization interface [polypeptide binding]; other site 516950001103 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 516950001104 DNA binding residues [nucleotide binding] 516950001105 dimerization interface [polypeptide binding]; other site 516950001106 A new structural DNA glycosylase; Region: AlkD_like; cl11434 516950001107 A new structural DNA glycosylase; Region: AlkD_like; cl11434 516950001108 A new structural DNA glycosylase; Region: AlkD_like; cl11434 516950001109 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 516950001110 active site 516950001111 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 516950001112 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 516950001113 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 516950001114 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 516950001115 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 516950001116 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 516950001117 Integrase core domain; Region: rve_2; pfam13333 516950001118 Integrase core domain; Region: rve; pfam00665 516950001119 HTH-like domain; Region: HTH_21; pfam13276 516950001120 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 516950001121 Helix-turn-helix domain; Region: HTH_28; pfam13518 516950001122 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 516950001123 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 516950001124 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 516950001125 active site 516950001126 P-loop; other site 516950001127 phosphorylation site [posttranslational modification] 516950001128 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 516950001129 active site 516950001130 P-loop; other site 516950001131 phosphorylation site [posttranslational modification] 516950001132 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 516950001133 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 516950001134 active site 516950001135 P-loop; other site 516950001136 phosphorylation site [posttranslational modification] 516950001137 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 516950001138 active site 516950001139 phosphorylation site [posttranslational modification] 516950001140 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 516950001141 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 516950001142 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 516950001143 trigger factor; Provisional; Region: tig; PRK01490 516950001144 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 516950001145 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 516950001146 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 516950001147 H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815 516950001148 DNA binding site [nucleotide binding] 516950001149 AAA domain; Region: AAA_30; pfam13604 516950001150 Family description; Region: UvrD_C_2; pfam13538 516950001151 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 516950001152 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462 516950001153 Catalytic site [active] 516950001154 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 516950001155 ribonuclease HIII; Provisional; Region: PRK00996 516950001156 Domain of unknown function (DUF3378); Region: DUF3378; pfam11858 516950001157 bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590 516950001158 RNA/DNA hybrid binding site [nucleotide binding]; other site 516950001159 active site 516950001160 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 516950001161 Colicin V production protein; Region: Colicin_V; pfam02674 516950001162 Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: COG1193 516950001163 MutS domain III; Region: MutS_III; pfam05192 516950001164 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 516950001165 Walker A/P-loop; other site 516950001166 ATP binding site [chemical binding]; other site 516950001167 Q-loop/lid; other site 516950001168 ABC transporter signature motif; other site 516950001169 Walker B; other site 516950001170 D-loop; other site 516950001171 H-loop/switch region; other site 516950001172 Smr domain; Region: Smr; pfam01713 516950001173 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 516950001174 amino acid carrier protein; Region: agcS; TIGR00835 516950001175 Uncharacterized conserved protein [Function unknown]; Region: COG2128 516950001176 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 516950001177 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 516950001178 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 516950001179 C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325 516950001180 gating phenylalanine in ion channel; other site 516950001181 seryl-tRNA synthetase; Provisional; Region: PRK05431 516950001182 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 516950001183 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 516950001184 dimer interface [polypeptide binding]; other site 516950001185 active site 516950001186 motif 1; other site 516950001187 motif 2; other site 516950001188 motif 3; other site 516950001189 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4687 516950001190 aspartate kinase; Reviewed; Region: PRK09034 516950001191 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 516950001192 putative catalytic residues [active] 516950001193 putative nucleotide binding site [chemical binding]; other site 516950001194 putative aspartate binding site [chemical binding]; other site 516950001195 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 516950001196 allosteric regulatory residue; other site 516950001197 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 516950001198 enoyl-CoA hydratase; Provisional; Region: PRK07260 516950001199 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 516950001200 substrate binding site [chemical binding]; other site 516950001201 oxyanion hole (OAH) forming residues; other site 516950001202 trimer interface [polypeptide binding]; other site 516950001203 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 516950001204 MarR family; Region: MarR_2; pfam12802 516950001205 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 516950001206 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 516950001207 dimer interface [polypeptide binding]; other site 516950001208 active site 516950001209 CoA binding pocket [chemical binding]; other site 516950001210 acyl carrier protein; Provisional; Region: acpP; PRK00982 516950001211 putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151 516950001212 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 516950001213 FMN binding site [chemical binding]; other site 516950001214 substrate binding site [chemical binding]; other site 516950001215 putative catalytic residue [active] 516950001216 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 516950001217 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 516950001218 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 516950001219 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 516950001220 NAD(P) binding site [chemical binding]; other site 516950001221 homotetramer interface [polypeptide binding]; other site 516950001222 homodimer interface [polypeptide binding]; other site 516950001223 active site 516950001224 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 516950001225 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 516950001226 dimer interface [polypeptide binding]; other site 516950001227 active site 516950001228 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 516950001229 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 516950001230 carboxyltransferase (CT) interaction site; other site 516950001231 biotinylation site [posttranslational modification]; other site 516950001232 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 516950001233 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 516950001234 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 516950001235 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 516950001236 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 516950001237 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 516950001238 Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571 516950001239 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 516950001240 acetyl-CoA carboxylase subunit alpha; Provisional; Region: PRK12319 516950001241 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 516950001242 putative RNA binding site [nucleotide binding]; other site 516950001243 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 516950001244 elongation factor P; Validated; Region: PRK00529 516950001245 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 516950001246 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 516950001247 RNA binding site [nucleotide binding]; other site 516950001248 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 516950001249 RNA binding site [nucleotide binding]; other site 516950001250 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 516950001251 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 516950001252 GatB domain; Region: GatB_Yqey; pfam02637 516950001253 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 516950001254 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 516950001255 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 516950001256 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 516950001257 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 516950001258 G1 box; other site 516950001259 putative GEF interaction site [polypeptide binding]; other site 516950001260 GTP/Mg2+ binding site [chemical binding]; other site 516950001261 Switch I region; other site 516950001262 G2 box; other site 516950001263 G3 box; other site 516950001264 Switch II region; other site 516950001265 G4 box; other site 516950001266 G5 box; other site 516950001267 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 516950001268 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 516950001269 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 516950001270 active site 516950001271 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 516950001272 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 516950001273 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 516950001274 Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461 516950001275 DAK2 domain; Region: Dak2; pfam02734 516950001276 acetolactate synthase catalytic subunit; Reviewed; Region: PRK07282 516950001277 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 516950001278 PYR/PP interface [polypeptide binding]; other site 516950001279 dimer interface [polypeptide binding]; other site 516950001280 TPP binding site [chemical binding]; other site 516950001281 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 516950001282 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 516950001283 TPP-binding site [chemical binding]; other site 516950001284 dimer interface [polypeptide binding]; other site 516950001285 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 516950001286 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 516950001287 putative valine binding site [chemical binding]; other site 516950001288 dimer interface [polypeptide binding]; other site 516950001289 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 516950001290 ketol-acid reductoisomerase; Provisional; Region: PRK05479 516950001291 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 516950001292 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 516950001293 threonine dehydratase; Validated; Region: PRK08639 516950001294 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 516950001295 tetramer interface [polypeptide binding]; other site 516950001296 pyridoxal 5'-phosphate binding site [chemical binding]; other site 516950001297 catalytic residue [active] 516950001298 C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585 516950001299 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 516950001300 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 516950001301 Walker A/P-loop; other site 516950001302 ATP binding site [chemical binding]; other site 516950001303 Q-loop/lid; other site 516950001304 ABC transporter signature motif; other site 516950001305 Walker B; other site 516950001306 D-loop; other site 516950001307 H-loop/switch region; other site 516950001308 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 516950001309 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 516950001310 substrate binding pocket [chemical binding]; other site 516950001311 membrane-bound complex binding site; other site 516950001312 hinge residues; other site 516950001313 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 516950001314 dimer interface [polypeptide binding]; other site 516950001315 conserved gate region; other site 516950001316 putative PBP binding loops; other site 516950001317 ABC-ATPase subunit interface; other site 516950001318 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 516950001319 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 516950001320 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 516950001321 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 516950001322 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 516950001323 Transposase; Region: DDE_Tnp_ISL3; pfam01610 516950001324 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 516950001325 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 516950001326 active site 516950001327 DNA polymerase IV; Validated; Region: PRK02406 516950001328 DNA binding site [nucleotide binding] 516950001329 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 516950001330 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 516950001331 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 516950001332 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 516950001333 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 516950001334 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 516950001335 TrkA-N domain; Region: TrkA_N; pfam02254 516950001336 TrkA-C domain; Region: TrkA_C; pfam02080 516950001337 TrkA-N domain; Region: TrkA_N; pfam02254 516950001338 TrkA-C domain; Region: TrkA_C; pfam02080 516950001339 Uncharacterized conserved protein [Function unknown]; Region: COG1912 516950001340 hypothetical protein; Provisional; Region: PRK13661 516950001341 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 516950001342 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 516950001343 Walker A/P-loop; other site 516950001344 ATP binding site [chemical binding]; other site 516950001345 Q-loop/lid; other site 516950001346 ABC transporter signature motif; other site 516950001347 Walker B; other site 516950001348 D-loop; other site 516950001349 H-loop/switch region; other site 516950001350 ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558 516950001351 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 516950001352 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 516950001353 Walker A/P-loop; other site 516950001354 ATP binding site [chemical binding]; other site 516950001355 Q-loop/lid; other site 516950001356 ABC transporter signature motif; other site 516950001357 Walker B; other site 516950001358 D-loop; other site 516950001359 H-loop/switch region; other site 516950001360 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 516950001361 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 516950001362 Predicted membrane protein [Function unknown]; Region: COG3601 516950001363 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 516950001364 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 516950001365 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 516950001366 active site 516950001367 ParB-like nuclease domain; Region: ParBc; cl02129 516950001368 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 516950001369 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 516950001370 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 516950001371 CTP synthetase; Validated; Region: pyrG; PRK05380 516950001372 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 516950001373 Catalytic site [active] 516950001374 active site 516950001375 UTP binding site [chemical binding]; other site 516950001376 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 516950001377 active site 516950001378 putative oxyanion hole; other site 516950001379 catalytic triad [active] 516950001380 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 516950001381 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 516950001382 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 516950001383 PhoU domain; Region: PhoU; pfam01895 516950001384 PhoU domain; Region: PhoU; pfam01895 516950001385 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 516950001386 Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724 516950001387 Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins. The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with...; Region: GH85_ENGase; cd06547 516950001388 putative active site [active] 516950001389 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 516950001390 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 516950001391 Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523 516950001392 G5 domain; Region: G5; pfam07501 516950001393 phosphoglycerate kinase; Provisional; Region: pgk; PRK00073 516950001394 Phosphoglycerate kinase; Region: PGK; pfam00162 516950001395 substrate binding site [chemical binding]; other site 516950001396 hinge regions; other site 516950001397 ADP binding site [chemical binding]; other site 516950001398 catalytic site [active] 516950001399 Predicted membrane protein [Function unknown]; Region: COG4129 516950001400 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 516950001401 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 516950001402 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 516950001403 DNA binding residues [nucleotide binding] 516950001404 putative dimer interface [polypeptide binding]; other site 516950001405 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 516950001406 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 516950001407 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 516950001408 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 516950001409 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 516950001410 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 516950001411 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 516950001412 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 516950001413 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 516950001414 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 516950001415 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 516950001416 HsdM N-terminal domain; Region: HsdM_N; pfam12161 516950001417 Methyltransferase domain; Region: Methyltransf_26; pfam13659 516950001418 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 516950001419 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 516950001420 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 516950001421 ATP binding site [chemical binding]; other site 516950001422 putative Mg++ binding site [ion binding]; other site 516950001423 Protein of unknown function (DUF2812); Region: DUF2812; pfam11193 516950001424 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 516950001425 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 516950001426 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 516950001427 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 516950001428 dimer interface [polypeptide binding]; other site 516950001429 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 516950001430 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 516950001431 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 516950001432 nucleotide binding site [chemical binding]; other site 516950001433 NEF interaction site [polypeptide binding]; other site 516950001434 SBD interface [polypeptide binding]; other site 516950001435 chaperone protein DnaJ; Provisional; Region: PRK14276 516950001436 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 516950001437 HSP70 interaction site [polypeptide binding]; other site 516950001438 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 516950001439 substrate binding site [polypeptide binding]; other site 516950001440 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 516950001441 Zn binding sites [ion binding]; other site 516950001442 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 516950001443 substrate binding site [polypeptide binding]; other site 516950001444 dimer interface [polypeptide binding]; other site 516950001445 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 516950001446 HIT family signature motif; other site 516950001447 catalytic residue [active] 516950001448 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 516950001449 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 516950001450 Walker A/P-loop; other site 516950001451 ATP binding site [chemical binding]; other site 516950001452 Q-loop/lid; other site 516950001453 ABC transporter signature motif; other site 516950001454 Walker B; other site 516950001455 D-loop; other site 516950001456 H-loop/switch region; other site 516950001457 Predicted ABC-type exoprotein transport system, permease component [Intracellular trafficking and secretion]; Region: EcsB; COG4473 516950001458 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 516950001459 LytTr DNA-binding domain; Region: LytTR; pfam04397 516950001460 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 516950001461 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 516950001462 active site 516950001463 phosphorylation site [posttranslational modification] 516950001464 intermolecular recognition site; other site 516950001465 dimerization interface [polypeptide binding]; other site 516950001466 LytTr DNA-binding domain; Region: LytTR; pfam04397 516950001467 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 516950001468 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 516950001469 ATP binding site [chemical binding]; other site 516950001470 Mg2+ binding site [ion binding]; other site 516950001471 G-X-G motif; other site 516950001472 bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000 516950001473 HlyD family secretion protein; Region: HlyD_3; pfam13437 516950001474 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 516950001475 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 516950001476 putative active site [active] 516950001477 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 516950001478 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 516950001479 Walker A/P-loop; other site 516950001480 ATP binding site [chemical binding]; other site 516950001481 Q-loop/lid; other site 516950001482 ABC transporter signature motif; other site 516950001483 Walker B; other site 516950001484 D-loop; other site 516950001485 H-loop/switch region; other site 516950001486 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 516950001487 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 516950001488 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 516950001489 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 516950001490 Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439 516950001491 CAAX protease self-immunity; Region: Abi; pfam02517 516950001492 CAAX protease self-immunity; Region: Abi; pfam02517 516950001493 Phosphotransferase enzyme family; Region: APH; pfam01636 516950001494 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 516950001495 substrate binding site [chemical binding]; other site 516950001496 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 516950001497 S-adenosylmethionine binding site [chemical binding]; other site 516950001498 ribosome maturation protein RimP; Reviewed; Region: PRK00092 516950001499 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 516950001500 putative oligomer interface [polypeptide binding]; other site 516950001501 putative RNA binding site [nucleotide binding]; other site 516950001502 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 516950001503 NusA N-terminal domain; Region: NusA_N; pfam08529 516950001504 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 516950001505 RNA binding site [nucleotide binding]; other site 516950001506 homodimer interface [polypeptide binding]; other site 516950001507 NusA-like KH domain; Region: KH_5; pfam13184 516950001508 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 516950001509 G-X-X-G motif; other site 516950001510 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 516950001511 putative RNA binding cleft [nucleotide binding]; other site 516950001512 hypothetical protein; Provisional; Region: PRK07283 516950001513 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 516950001514 translation initiation factor IF-2; Region: IF-2; TIGR00487 516950001515 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 516950001516 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 516950001517 G1 box; other site 516950001518 putative GEF interaction site [polypeptide binding]; other site 516950001519 GTP/Mg2+ binding site [chemical binding]; other site 516950001520 Switch I region; other site 516950001521 G2 box; other site 516950001522 G3 box; other site 516950001523 Switch II region; other site 516950001524 G4 box; other site 516950001525 G5 box; other site 516950001526 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 516950001527 Translation-initiation factor 2; Region: IF-2; pfam11987 516950001528 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 516950001529 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 516950001530 Domain of unknown function (DUF1858); Region: DUF1858; pfam08984 516950001531 Uncharacterized conserved protein [Function unknown]; Region: COG2461 516950001532 Family of unknown function (DUF438); Region: DUF438; pfam04282 516950001533 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 516950001534 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 516950001535 putative active site [active] 516950001536 heme pocket [chemical binding]; other site 516950001537 Domain of unknown function (DUF1912); Region: DUF1912; pfam08930 516950001538 hypothetical protein; Provisional; Region: PRK07758 516950001539 Flavin Reductases; Region: FlaRed; cl00801 516950001540 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 516950001541 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 516950001542 Coenzyme A binding pocket [chemical binding]; other site 516950001543 AAA domain; Region: AAA_18; pfam13238 516950001544 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 516950001545 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 516950001546 active site 516950001547 HIGH motif; other site 516950001548 nucleotide binding site [chemical binding]; other site 516950001549 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 516950001550 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 516950001551 active site 516950001552 KMSKS motif; other site 516950001553 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 516950001554 tRNA binding surface [nucleotide binding]; other site 516950001555 anticodon binding site; other site 516950001556 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 516950001557 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 516950001558 cofactor binding site; other site 516950001559 AAA domain; Region: AAA_21; pfam13304 516950001560 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 516950001561 ABC transporter signature motif; other site 516950001562 Walker B; other site 516950001563 D-loop; other site 516950001564 H-loop/switch region; other site 516950001565 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 516950001566 Fic/DOC family; Region: Fic; pfam02661 516950001567 Integrase core domain; Region: rve; pfam00665 516950001568 Integrase core domain; Region: rve_2; pfam13333 516950001569 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 516950001570 Homeodomain-like domain; Region: HTH_23; cl17451 516950001571 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4951 516950001572 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 516950001573 putative Mg++ binding site [ion binding]; other site 516950001574 C-terminal putative phospholipase D-like domain of uncharacterized prokaryotic HKD family nucleases fused to DEAD/DEAH box helicases; Region: PLDc_C_DEXD_like; cd09126 516950001575 transcriptional antiterminator BglG; Provisional; Region: PRK09772 516950001576 CAT RNA binding domain; Region: CAT_RBD; smart01061 516950001577 PRD domain; Region: PRD; pfam00874 516950001578 PRD domain; Region: PRD; pfam00874 516950001579 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 516950001580 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 516950001581 active site turn [active] 516950001582 phosphorylation site [posttranslational modification] 516950001583 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 516950001584 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 516950001585 HPr interaction site; other site 516950001586 glycerol kinase (GK) interaction site [polypeptide binding]; other site 516950001587 active site 516950001588 phosphorylation site [posttranslational modification] 516950001589 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 516950001590 beta-galactosidase; Region: BGL; TIGR03356 516950001591 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 516950001592 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 516950001593 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 516950001594 dimer interface [polypeptide binding]; other site 516950001595 motif 1; other site 516950001596 active site 516950001597 motif 2; other site 516950001598 motif 3; other site 516950001599 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 516950001600 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 516950001601 Coenzyme A binding pocket [chemical binding]; other site 516950001602 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 516950001603 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 516950001604 putative tRNA-binding site [nucleotide binding]; other site 516950001605 B3/4 domain; Region: B3_4; pfam03483 516950001606 tRNA synthetase B5 domain; Region: B5; smart00874 516950001607 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 516950001608 dimer interface [polypeptide binding]; other site 516950001609 motif 1; other site 516950001610 motif 3; other site 516950001611 motif 2; other site 516950001612 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 516950001613 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 516950001614 putative catalytic site [active] 516950001615 putative metal binding site [ion binding]; other site 516950001616 putative phosphate binding site [ion binding]; other site 516950001617 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 516950001618 Helix-turn-helix domain; Region: HTH_38; pfam13936 516950001619 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 516950001620 non-specific DNA binding site [nucleotide binding]; other site 516950001621 salt bridge; other site 516950001622 sequence-specific DNA binding site [nucleotide binding]; other site 516950001623 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 516950001624 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 516950001625 THF binding site; other site 516950001626 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 516950001627 substrate binding site [chemical binding]; other site 516950001628 THF binding site; other site 516950001629 zinc-binding site [ion binding]; other site 516950001630 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 516950001631 FAD binding site [chemical binding]; other site 516950001632 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 516950001633 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 516950001634 RNase E interface [polypeptide binding]; other site 516950001635 trimer interface [polypeptide binding]; other site 516950001636 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 516950001637 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 516950001638 RNase E interface [polypeptide binding]; other site 516950001639 trimer interface [polypeptide binding]; other site 516950001640 active site 516950001641 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 516950001642 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 516950001643 RNA binding site [nucleotide binding]; other site 516950001644 domain interface; other site 516950001645 serine O-acetyltransferase; Region: cysE; TIGR01172 516950001646 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 516950001647 trimer interface [polypeptide binding]; other site 516950001648 active site 516950001649 substrate binding site [chemical binding]; other site 516950001650 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 516950001651 Coenzyme A binding pocket [chemical binding]; other site 516950001652 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 516950001653 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 516950001654 Coenzyme A binding pocket [chemical binding]; other site 516950001655 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 516950001656 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 516950001657 active site 516950001658 HIGH motif; other site 516950001659 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 516950001660 KMSKS motif; other site 516950001661 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 516950001662 tRNA binding surface [nucleotide binding]; other site 516950001663 anticodon binding site; other site 516950001664 Ribonuclease III family protein [Replication, recombination, and repair]; Region: COG1939 516950001665 active site 516950001666 metal binding site [ion binding]; metal-binding site 516950001667 dimerization interface [polypeptide binding]; other site 516950001668 Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508 516950001669 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 516950001670 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 516950001671 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 516950001672 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 516950001673 FtsX-like permease family; Region: FtsX; pfam02687 516950001674 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 516950001675 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 516950001676 Walker A/P-loop; other site 516950001677 ATP binding site [chemical binding]; other site 516950001678 Q-loop/lid; other site 516950001679 ABC transporter signature motif; other site 516950001680 Walker B; other site 516950001681 D-loop; other site 516950001682 H-loop/switch region; other site 516950001683 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 516950001684 FtsX-like permease family; Region: FtsX; pfam02687 516950001685 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 516950001686 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 516950001687 active site 516950001688 phosphorylation site [posttranslational modification] 516950001689 intermolecular recognition site; other site 516950001690 dimerization interface [polypeptide binding]; other site 516950001691 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 516950001692 DNA binding site [nucleotide binding] 516950001693 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 516950001694 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 516950001695 dimerization interface [polypeptide binding]; other site 516950001696 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 516950001697 dimer interface [polypeptide binding]; other site 516950001698 phosphorylation site [posttranslational modification] 516950001699 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 516950001700 ATP binding site [chemical binding]; other site 516950001701 Mg2+ binding site [ion binding]; other site 516950001702 G-X-G motif; other site 516950001703 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 516950001704 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 516950001705 intersubunit interface [polypeptide binding]; other site 516950001706 active site 516950001707 zinc binding site [ion binding]; other site 516950001708 Na+ binding site [ion binding]; other site 516950001709 Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097 516950001710 Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794 516950001711 NAD(P) binding domain of ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198 516950001712 FAD binding pocket [chemical binding]; other site 516950001713 FAD binding motif [chemical binding]; other site 516950001714 phosphate binding motif [ion binding]; other site 516950001715 beta-alpha-beta structure motif; other site 516950001716 NAD binding pocket [chemical binding]; other site 516950001717 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 516950001718 dimer interface [polypeptide binding]; other site 516950001719 conserved gate region; other site 516950001720 putative PBP binding loops; other site 516950001721 ABC-ATPase subunit interface; other site 516950001722 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 516950001723 dimer interface [polypeptide binding]; other site 516950001724 conserved gate region; other site 516950001725 putative PBP binding loops; other site 516950001726 ABC-ATPase subunit interface; other site 516950001727 bifunctional adhesin/ABC transporter aspartate/glutamate-binding protein; Reviewed; Region: PRK11917 516950001728 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 516950001729 substrate binding pocket [chemical binding]; other site 516950001730 membrane-bound complex binding site; other site 516950001731 hinge residues; other site 516950001732 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 516950001733 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 516950001734 Walker A/P-loop; other site 516950001735 ATP binding site [chemical binding]; other site 516950001736 Q-loop/lid; other site 516950001737 ABC transporter signature motif; other site 516950001738 Walker B; other site 516950001739 D-loop; other site 516950001740 H-loop/switch region; other site 516950001741 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 516950001742 DHH family; Region: DHH; pfam01368 516950001743 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199 516950001744 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 516950001745 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 516950001746 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 516950001747 Predicted esterase [General function prediction only]; Region: COG0627 516950001748 S-formylglutathione hydrolase; Region: PLN02442 516950001749 Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348 516950001750 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 516950001751 FemAB family; Region: FemAB; pfam02388 516950001752 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 516950001753 active site 516950001754 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 516950001755 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 516950001756 GIY-YIG motif/motif A; other site 516950001757 active site 516950001758 catalytic site [active] 516950001759 putative DNA binding site [nucleotide binding]; other site 516950001760 metal binding site [ion binding]; metal-binding site 516950001761 UvrB/uvrC motif; Region: UVR; pfam02151 516950001762 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 516950001763 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 516950001764 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 516950001765 active site 516950001766 metal binding site [ion binding]; metal-binding site 516950001767 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 516950001768 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 516950001769 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 516950001770 substrate binding pocket [chemical binding]; other site 516950001771 membrane-bound complex binding site; other site 516950001772 hinge residues; other site 516950001773 Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137 516950001774 dimer interface [polypeptide binding]; other site 516950001775 FMN binding site [chemical binding]; other site 516950001776 dipeptidase PepV; Reviewed; Region: PRK07318 516950001777 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 516950001778 active site 516950001779 metal binding site [ion binding]; metal-binding site 516950001780 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 516950001781 putative uracil binding site [chemical binding]; other site 516950001782 putative active site [active] 516950001783 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 516950001784 Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525 516950001785 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 516950001786 M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657 516950001787 putative oligomer interface [polypeptide binding]; other site 516950001788 putative active site [active] 516950001789 metal binding site [ion binding]; metal-binding site 516950001790 Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537 516950001791 nucleotide binding site/active site [active] 516950001792 HIT family signature motif; other site 516950001793 catalytic residue [active] 516950001794 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876 516950001795 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 516950001796 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 516950001797 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 516950001798 23S rRNA interface [nucleotide binding]; other site 516950001799 L7/L12 interface [polypeptide binding]; other site 516950001800 putative thiostrepton binding site; other site 516950001801 L25 interface [polypeptide binding]; other site 516950001802 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 516950001803 mRNA/rRNA interface [nucleotide binding]; other site 516950001804 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251 516950001805 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 516950001806 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 516950001807 Walker A/P-loop; other site 516950001808 ATP binding site [chemical binding]; other site 516950001809 Q-loop/lid; other site 516950001810 ABC transporter signature motif; other site 516950001811 Walker B; other site 516950001812 D-loop; other site 516950001813 H-loop/switch region; other site 516950001814 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 516950001815 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 516950001816 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG3694 516950001817 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 516950001818 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 516950001819 Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922 516950001820 Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475 516950001821 putative active site [active] 516950001822 catalytic triad [active] 516950001823 PA_2: Protease-associated (PA) domain subgroup 2. A subgroup of PA-domain containing proteins. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is...; Region: PA_2; cd04819 516950001824 PA/protease or protease-like domain interface [polypeptide binding]; other site 516950001825 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 516950001826 catalytic residues [active] 516950001827 Fn3-like domain (DUF1034); Region: DUF1034; pfam06280 516950001828 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 516950001829 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 516950001830 active site 516950001831 phosphorylation site [posttranslational modification] 516950001832 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 516950001833 active site 516950001834 P-loop; other site 516950001835 phosphorylation site [posttranslational modification] 516950001836 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 516950001837 PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611 516950001838 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 516950001839 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 516950001840 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 516950001841 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 516950001842 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 516950001843 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 516950001844 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 516950001845 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 516950001846 Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532 516950001847 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3583 516950001848 G5 domain; Region: G5; pfam07501 516950001849 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 516950001850 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 516950001851 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3666 516950001852 Protein of unknown function (DUF3397); Region: DUF3397; pfam11877 516950001853 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 516950001854 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 516950001855 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 516950001856 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 516950001857 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 516950001858 Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295 516950001859 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 516950001860 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 516950001861 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 516950001862 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 516950001863 catalytic residues [active] 516950001864 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 516950001865 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 516950001866 SelR domain; Region: SelR; pfam01641 516950001867 Response regulator receiver domain; Region: Response_reg; pfam00072 516950001868 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 516950001869 active site 516950001870 phosphorylation site [posttranslational modification] 516950001871 intermolecular recognition site; other site 516950001872 dimerization interface [polypeptide binding]; other site 516950001873 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 516950001874 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 516950001875 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 516950001876 Cache domain; Region: Cache_1; pfam02743 516950001877 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 516950001878 dimerization interface [polypeptide binding]; other site 516950001879 Histidine kinase; Region: His_kinase; pfam06580 516950001880 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 516950001881 ATP binding site [chemical binding]; other site 516950001882 Mg2+ binding site [ion binding]; other site 516950001883 G-X-G motif; other site 516950001884 hypothetical protein; Provisional; Region: PRK13690 516950001885 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 516950001886 M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342 516950001887 M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580 516950001888 aminodeoxychorismate synthase; Provisional; Region: PRK07508 516950001889 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 516950001890 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 516950001891 substrate-cofactor binding pocket; other site 516950001892 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 516950001893 pyridoxal 5'-phosphate binding site [chemical binding]; other site 516950001894 catalytic residue [active] 516950001895 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 516950001896 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 516950001897 Excalibur calcium-binding domain; Region: Excalibur; smart00894 516950001898 Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553 516950001899 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 516950001900 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 516950001901 nucleotide binding site [chemical binding]; other site 516950001902 thymidylate synthase; Reviewed; Region: thyA; PRK01827 516950001903 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 516950001904 dimerization interface [polypeptide binding]; other site 516950001905 active site 516950001906 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 516950001907 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 516950001908 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 516950001909 GTPases [General function prediction only]; Region: HflX; COG2262 516950001910 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 516950001911 HflX GTPase family; Region: HflX; cd01878 516950001912 G1 box; other site 516950001913 GTP/Mg2+ binding site [chemical binding]; other site 516950001914 Switch I region; other site 516950001915 G2 box; other site 516950001916 G3 box; other site 516950001917 Switch II region; other site 516950001918 G4 box; other site 516950001919 G5 box; other site 516950001920 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 516950001921 ribonuclease Z; Region: RNase_Z; TIGR02651 516950001922 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 516950001923 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 516950001924 NAD(P) binding site [chemical binding]; other site 516950001925 active site 516950001926 Transcriptional regulator [Transcription]; Region: LysR; COG0583 516950001927 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 516950001928 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 516950001929 dimerization interface [polypeptide binding]; other site 516950001930 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 516950001931 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 516950001932 active site residue [active] 516950001933 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 516950001934 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 516950001935 RNA binding surface [nucleotide binding]; other site 516950001936 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 516950001937 active site 516950001938 uracil binding [chemical binding]; other site 516950001939 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 516950001940 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 516950001941 G1 box; other site 516950001942 putative GEF interaction site [polypeptide binding]; other site 516950001943 GTP/Mg2+ binding site [chemical binding]; other site 516950001944 Switch I region; other site 516950001945 G2 box; other site 516950001946 G3 box; other site 516950001947 Switch II region; other site 516950001948 G4 box; other site 516950001949 G5 box; other site 516950001950 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 516950001951 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 516950001952 Protein of unknown function (DUF3165); Region: DUF3165; pfam11364 516950001953 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891 516950001954 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 516950001955 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 516950001956 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 516950001957 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 516950001958 Walker A/P-loop; other site 516950001959 ATP binding site [chemical binding]; other site 516950001960 Q-loop/lid; other site 516950001961 ABC transporter signature motif; other site 516950001962 Walker B; other site 516950001963 D-loop; other site 516950001964 H-loop/switch region; other site 516950001965 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 516950001966 Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002 516950001967 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 516950001968 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 516950001969 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 516950001970 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 516950001971 homodimer interface [polypeptide binding]; other site 516950001972 active site 516950001973 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 516950001974 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 516950001975 Cell division protein FtsQ; Region: FtsQ; pfam03799 516950001976 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 516950001977 Peptidase family M50; Region: Peptidase_M50; pfam02163 516950001978 active site 516950001979 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 516950001980 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196 516950001981 ATP binding site [chemical binding]; other site 516950001982 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 516950001983 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 516950001984 Walker A/P-loop; other site 516950001985 ATP binding site [chemical binding]; other site 516950001986 Q-loop/lid; other site 516950001987 ABC transporter signature motif; other site 516950001988 Walker B; other site 516950001989 D-loop; other site 516950001990 H-loop/switch region; other site 516950001991 Integrase core domain; Region: rve; pfam00665 516950001992 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 516950001993 active site 516950001994 dimer interface [polypeptide binding]; other site 516950001995 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 516950001996 active site 516950001997 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 516950001998 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 516950001999 Walker A/P-loop; other site 516950002000 ATP binding site [chemical binding]; other site 516950002001 Q-loop/lid; other site 516950002002 ABC transporter signature motif; other site 516950002003 Walker B; other site 516950002004 D-loop; other site 516950002005 H-loop/switch region; other site 516950002006 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 516950002007 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 516950002008 substrate binding pocket [chemical binding]; other site 516950002009 membrane-bound complex binding site; other site 516950002010 hinge residues; other site 516950002011 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 516950002012 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 516950002013 Walker A/P-loop; other site 516950002014 ATP binding site [chemical binding]; other site 516950002015 Q-loop/lid; other site 516950002016 ABC transporter signature motif; other site 516950002017 Walker B; other site 516950002018 D-loop; other site 516950002019 H-loop/switch region; other site 516950002020 amine acid ABC transporter, permease protein, 3-TM region, His/Glu/Gln/Arg/opine family; Region: HEQRo_perm_3TM; TIGR01726 516950002021 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 516950002022 dimer interface [polypeptide binding]; other site 516950002023 conserved gate region; other site 516950002024 putative PBP binding loops; other site 516950002025 ABC-ATPase subunit interface; other site 516950002026 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 516950002027 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 516950002028 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 516950002029 dimer interface [polypeptide binding]; other site 516950002030 putative anticodon binding site; other site 516950002031 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 516950002032 motif 1; other site 516950002033 active site 516950002034 motif 2; other site 516950002035 motif 3; other site 516950002036 L-lactate oxidase; Region: L_lactate_ox; TIGR02708 516950002037 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 516950002038 teramer interface [polypeptide binding]; other site 516950002039 active site 516950002040 FMN binding site [chemical binding]; other site 516950002041 catalytic residues [active] 516950002042 Putative transcription activator [Transcription]; Region: TenA; COG0819 516950002043 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 516950002044 substrate binding site [chemical binding]; other site 516950002045 multimerization interface [polypeptide binding]; other site 516950002046 ATP binding site [chemical binding]; other site 516950002047 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 516950002048 thiamine phosphate binding site [chemical binding]; other site 516950002049 active site 516950002050 pyrophosphate binding site [ion binding]; other site 516950002051 ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721 516950002052 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 516950002053 Walker A/P-loop; other site 516950002054 ATP binding site [chemical binding]; other site 516950002055 ABC transporter; Region: ABC_tran; pfam00005 516950002056 Q-loop/lid; other site 516950002057 ABC transporter signature motif; other site 516950002058 Walker B; other site 516950002059 D-loop; other site 516950002060 H-loop/switch region; other site 516950002061 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 516950002062 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 516950002063 Walker A/P-loop; other site 516950002064 ATP binding site [chemical binding]; other site 516950002065 Q-loop/lid; other site 516950002066 ABC transporter signature motif; other site 516950002067 Walker B; other site 516950002068 D-loop; other site 516950002069 H-loop/switch region; other site 516950002070 Putative transcription activator [Transcription]; Region: TenA; COG0819 516950002071 Predicted membrane protein [Function unknown]; Region: COG4732 516950002072 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 516950002073 substrate binding site [chemical binding]; other site 516950002074 multimerization interface [polypeptide binding]; other site 516950002075 ATP binding site [chemical binding]; other site 516950002076 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 516950002077 thiamine phosphate binding site [chemical binding]; other site 516950002078 active site 516950002079 pyrophosphate binding site [ion binding]; other site 516950002080 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 516950002081 dimer interface [polypeptide binding]; other site 516950002082 substrate binding site [chemical binding]; other site 516950002083 ATP binding site [chemical binding]; other site 516950002084 Predicted transcriptional regulator [Transcription]; Region: COG3682 516950002085 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 516950002086 Plastocyanin domain containing protein [General function prediction only]; Region: COG4633 516950002087 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 516950002088 Cupredoxin-like domain; Region: Cupredoxin_1; cl17234 516950002089 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 516950002090 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 516950002091 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 516950002092 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 516950002093 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 516950002094 PYR/PP interface [polypeptide binding]; other site 516950002095 dimer interface [polypeptide binding]; other site 516950002096 tetramer interface [polypeptide binding]; other site 516950002097 TPP binding site [chemical binding]; other site 516950002098 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 516950002099 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 516950002100 TPP-binding site [chemical binding]; other site 516950002101 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 516950002102 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 516950002103 active site 516950002104 DDE superfamily endonuclease; Region: DDE_3; pfam13358 516950002105 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 516950002106 Winged helix-turn helix; Region: HTH_33; pfam13592 516950002107 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 516950002108 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 516950002109 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 516950002110 solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336 516950002111 putative substrate binding site 2 [chemical binding]; other site 516950002112 putative substrate binding site 1 [chemical binding]; other site 516950002113 Na binding site 1 [ion binding]; other site 516950002114 Na2 binding site [ion binding]; other site 516950002115 Na+-dependent transporters of the SNF family [General function prediction only]; Region: COG0733 516950002116 Helix-Turn-Helix DNA binding domain of the transcription regulators TipAL, Mta, and SkgA; Region: HTH_TipAL-Mta; cd01106 516950002117 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 516950002118 DNA binding residues [nucleotide binding] 516950002119 dimer interface [polypeptide binding]; other site 516950002120 TipAS antibiotic-recognition domain; Region: TipAS; pfam07739 516950002121 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 516950002122 putative active site [active] 516950002123 nucleotide binding site [chemical binding]; other site 516950002124 nudix motif; other site 516950002125 putative metal binding site [ion binding]; other site 516950002126 HI0933-like protein; Region: HI0933_like; pfam03486 516950002127 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307 516950002128 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 516950002129 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 516950002130 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 516950002131 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 516950002132 catalytic motif [active] 516950002133 Zn binding site [ion binding]; other site 516950002134 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 516950002135 active site 516950002136 Clp protease; Region: CLP_protease; pfam00574 516950002137 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 516950002138 oligomer interface [polypeptide binding]; other site 516950002139 active site residues [active] 516950002140 hypothetical protein; Provisional; Region: PRK02302 516950002141 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 516950002142 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347 516950002143 putative ligand binding site [chemical binding]; other site 516950002144 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 516950002145 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 516950002146 TM-ABC transporter signature motif; other site 516950002147 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 516950002148 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 516950002149 TM-ABC transporter signature motif; other site 516950002150 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 516950002151 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 516950002152 Walker A/P-loop; other site 516950002153 ATP binding site [chemical binding]; other site 516950002154 Q-loop/lid; other site 516950002155 ABC transporter signature motif; other site 516950002156 Walker B; other site 516950002157 D-loop; other site 516950002158 H-loop/switch region; other site 516950002159 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 516950002160 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 516950002161 Walker A/P-loop; other site 516950002162 ATP binding site [chemical binding]; other site 516950002163 Q-loop/lid; other site 516950002164 ABC transporter signature motif; other site 516950002165 Walker B; other site 516950002166 D-loop; other site 516950002167 H-loop/switch region; other site 516950002168 FOG: CBS domain [General function prediction only]; Region: COG0517 516950002169 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms. They produce...; Region: CBS_pair_ACT_assoc2; cd04585 516950002170 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116 516950002171 peptide chain release factor 2; Region: prfB; TIGR00020 516950002172 PCRF domain; Region: PCRF; pfam03462 516950002173 RF-1 domain; Region: RF-1; pfam00472 516950002174 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 516950002175 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 516950002176 Walker A/P-loop; other site 516950002177 ATP binding site [chemical binding]; other site 516950002178 Q-loop/lid; other site 516950002179 ABC transporter signature motif; other site 516950002180 Walker B; other site 516950002181 D-loop; other site 516950002182 H-loop/switch region; other site 516950002183 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 516950002184 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 516950002185 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 516950002186 PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003 516950002187 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 516950002188 active site turn [active] 516950002189 phosphorylation site [posttranslational modification] 516950002190 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 516950002191 HPr interaction site; other site 516950002192 glycerol kinase (GK) interaction site [polypeptide binding]; other site 516950002193 active site 516950002194 phosphorylation site [posttranslational modification] 516950002195 Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079 516950002196 putative catalytic site [active] 516950002197 putative metal binding site [ion binding]; other site 516950002198 putative phosphate binding site [ion binding]; other site 516950002199 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 516950002200 DEAD-like helicases superfamily; Region: DEXDc; smart00487 516950002201 ATP binding site [chemical binding]; other site 516950002202 Mg++ binding site [ion binding]; other site 516950002203 motif III; other site 516950002204 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 516950002205 nucleotide binding region [chemical binding]; other site 516950002206 ATP-binding site [chemical binding]; other site 516950002207 S-adenosylmethionine synthetase; Validated; Region: PRK05250 516950002208 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 516950002209 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 516950002210 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 516950002211 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 516950002212 Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741 516950002213 active site 516950002214 FMN binding site [chemical binding]; other site 516950002215 substrate binding site [chemical binding]; other site 516950002216 catalytic residues [active] 516950002217 homodimer interface [polypeptide binding]; other site 516950002218 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 516950002219 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 516950002220 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 516950002221 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 516950002222 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 516950002223 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470 516950002224 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455 516950002225 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 516950002226 FeS/SAM binding site; other site 516950002227 Glycopeptide antibiotics resistance protein [Defense mechanisms]; Region: VanZ; COG4767 516950002228 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 516950002229 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 516950002230 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 516950002231 ABC transporter; Region: ABC_tran_2; pfam12848 516950002232 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 516950002233 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 516950002234 active site 516950002235 D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634 516950002236 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 516950002237 Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837 516950002238 KH domain; Region: KH_4; pfam13083 516950002239 G-X-X-G motif; other site 516950002240 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 516950002241 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 516950002242 RimM N-terminal domain; Region: RimM; pfam01782 516950002243 PRC-barrel domain; Region: PRC; pfam05239 516950002244 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 516950002245 ATP cone domain; Region: ATP-cone; pfam03477 516950002246 Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901 516950002247 Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268 516950002248 glutathione reductase; Validated; Region: PRK06116 516950002249 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 516950002250 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 516950002251 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 516950002252 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 516950002253 HlyD family secretion protein; Region: HlyD_3; pfam13437 516950002254 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 516950002255 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 516950002256 Walker A/P-loop; other site 516950002257 ATP binding site [chemical binding]; other site 516950002258 Q-loop/lid; other site 516950002259 ABC transporter signature motif; other site 516950002260 Walker B; other site 516950002261 D-loop; other site 516950002262 H-loop/switch region; other site 516950002263 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 516950002264 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 516950002265 FtsX-like permease family; Region: FtsX; pfam02687 516950002266 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 516950002267 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 516950002268 active site 516950002269 HIGH motif; other site 516950002270 KMSKS motif; other site 516950002271 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 516950002272 tRNA binding surface [nucleotide binding]; other site 516950002273 anticodon binding site; other site 516950002274 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 516950002275 dimer interface [polypeptide binding]; other site 516950002276 putative tRNA-binding site [nucleotide binding]; other site 516950002277 Predicted transcriptional regulators [Transcription]; Region: COG1695 516950002278 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 516950002279 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 516950002280 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 516950002281 active site 516950002282 catalytic tetrad [active] 516950002283 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 516950002284 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 516950002285 classical (c) SDRs; Region: SDR_c; cd05233 516950002286 NAD(P) binding site [chemical binding]; other site 516950002287 active site 516950002288 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 516950002289 nudix motif; other site 516950002290 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574 516950002291 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 516950002292 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 516950002293 Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308 516950002294 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 516950002295 Zn binding site [ion binding]; other site 516950002296 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 516950002297 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 516950002298 active site 516950002299 phosphorylation site [posttranslational modification] 516950002300 intermolecular recognition site; other site 516950002301 dimerization interface [polypeptide binding]; other site 516950002302 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 516950002303 DNA binding site [nucleotide binding] 516950002304 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 516950002305 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 516950002306 dimer interface [polypeptide binding]; other site 516950002307 phosphorylation site [posttranslational modification] 516950002308 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 516950002309 ATP binding site [chemical binding]; other site 516950002310 Mg2+ binding site [ion binding]; other site 516950002311 G-X-G motif; other site 516950002312 Protein of unknown function (DUF3270); Region: DUF3270; pfam11674 516950002313 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 516950002314 Peptidase family U32; Region: Peptidase_U32; pfam01136 516950002315 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK07246 516950002316 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 516950002317 active site 516950002318 catalytic site [active] 516950002319 substrate binding site [chemical binding]; other site 516950002320 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 516950002321 ATP binding site [chemical binding]; other site 516950002322 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 516950002323 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 516950002324 DJ-1 family protein; Region: not_thiJ; TIGR01383 516950002325 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 516950002326 conserved cys residue [active] 516950002327 haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549 516950002328 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 516950002329 motif II; other site 516950002330 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 516950002331 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 516950002332 Mg2+ binding site [ion binding]; other site 516950002333 G-X-G motif; other site 516950002334 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 516950002335 anchoring element; other site 516950002336 dimer interface [polypeptide binding]; other site 516950002337 ATP binding site [chemical binding]; other site 516950002338 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 516950002339 active site 516950002340 putative metal-binding site [ion binding]; other site 516950002341 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 516950002342 Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477 516950002343 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 516950002344 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 516950002345 Domain of unknown function (DUF1827); Region: DUF1827; pfam08860 516950002346 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 516950002347 nudix motif; other site 516950002348 Transposase; Region: HTH_Tnp_IS630; pfam01710 516950002349 Helix-turn-helix domain; Region: HTH_28; pfam13518 516950002350 Winged helix-turn helix; Region: HTH_33; pfam13592 516950002351 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 516950002352 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 516950002353 Walker A motif; other site 516950002354 ATP binding site [chemical binding]; other site 516950002355 Walker B motif; other site 516950002356 arginine finger; other site 516950002357 UvrB/uvrC motif; Region: UVR; pfam02151 516950002358 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 516950002359 Walker A motif; other site 516950002360 ATP binding site [chemical binding]; other site 516950002361 Walker B motif; other site 516950002362 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 516950002363 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703 516950002364 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 516950002365 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 516950002366 dimer interface [polypeptide binding]; other site 516950002367 conserved gate region; other site 516950002368 putative PBP binding loops; other site 516950002369 ABC-ATPase subunit interface; other site 516950002370 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 516950002371 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 516950002372 Walker A/P-loop; other site 516950002373 ATP binding site [chemical binding]; other site 516950002374 Q-loop/lid; other site 516950002375 ABC transporter signature motif; other site 516950002376 Walker B; other site 516950002377 D-loop; other site 516950002378 H-loop/switch region; other site 516950002379 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179 516950002380 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 516950002381 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 516950002382 homodimer interface [polypeptide binding]; other site 516950002383 NADP binding site [chemical binding]; other site 516950002384 substrate binding site [chemical binding]; other site 516950002385 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 516950002386 putative substrate binding site [chemical binding]; other site 516950002387 putative ATP binding site [chemical binding]; other site 516950002388 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 516950002389 tetramer (dimer of dimers) interface [polypeptide binding]; other site 516950002390 active site 516950002391 dimer interface [polypeptide binding]; other site 516950002392 phosphopentomutase; Provisional; Region: PRK05362 516950002393 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 516950002394 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 516950002395 Protein of unknown function (DUF1697); Region: DUF1697; cl01557 516950002396 purine nucleoside phosphorylase; Provisional; Region: PRK08202 516950002397 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 516950002398 nucleophilic elbow; other site 516950002399 catalytic triad; other site 516950002400 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 516950002401 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 516950002402 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 516950002403 topology modulation protein; Provisional; Region: PRK07261 516950002404 AAA domain; Region: AAA_17; pfam13207 516950002405 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 516950002406 pantothenate kinase; Provisional; Region: PRK05439 516950002407 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 516950002408 ATP-binding site [chemical binding]; other site 516950002409 CoA-binding site [chemical binding]; other site 516950002410 Mg2+-binding site [ion binding]; other site 516950002411 Methyltransferase domain; Region: Methyltransf_31; pfam13847 516950002412 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 516950002413 S-adenosylmethionine binding site [chemical binding]; other site 516950002414 pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078 516950002415 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 516950002416 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 516950002417 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 516950002418 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 516950002419 intersubunit interface [polypeptide binding]; other site 516950002420 active site 516950002421 catalytic residue [active] 516950002422 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 516950002423 active site 516950002424 catalytic motif [active] 516950002425 Zn binding site [ion binding]; other site 516950002426 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 516950002427 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 516950002428 ligand binding site [chemical binding]; other site 516950002429 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 516950002430 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 516950002431 Walker A/P-loop; other site 516950002432 ATP binding site [chemical binding]; other site 516950002433 Q-loop/lid; other site 516950002434 ABC transporter signature motif; other site 516950002435 Walker B; other site 516950002436 D-loop; other site 516950002437 H-loop/switch region; other site 516950002438 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 516950002439 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 516950002440 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 516950002441 TM-ABC transporter signature motif; other site 516950002442 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 516950002443 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 516950002444 TM-ABC transporter signature motif; other site 516950002445 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 516950002446 Helix-turn-helix domain; Region: HTH_28; pfam13518 516950002447 HTH-like domain; Region: HTH_21; pfam13276 516950002448 Integrase core domain; Region: rve; pfam00665 516950002449 Integrase core domain; Region: rve_2; pfam13333 516950002450 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 516950002451 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 516950002452 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 516950002453 Mg2+ binding site [ion binding]; other site 516950002454 G-X-G motif; other site 516950002455 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 516950002456 anchoring element; other site 516950002457 dimer interface [polypeptide binding]; other site 516950002458 ATP binding site [chemical binding]; other site 516950002459 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 516950002460 active site 516950002461 putative metal-binding site [ion binding]; other site 516950002462 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 516950002463 DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061 516950002464 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 516950002465 CAP-like domain; other site 516950002466 active site 516950002467 primary dimer interface [polypeptide binding]; other site 516950002468 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 516950002469 branched-chain amino acid aminotransferase; Provisional; Region: PRK13357 516950002470 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 516950002471 homodimer interface [polypeptide binding]; other site 516950002472 substrate-cofactor binding pocket; other site 516950002473 catalytic residue [active] 516950002474 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 516950002475 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 516950002476 Predicted membrane protein [Function unknown]; Region: COG3819 516950002477 Predicted membrane protein [Function unknown]; Region: COG3817 516950002478 Protein of unknown function (DUF979); Region: DUF979; pfam06166 516950002479 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 516950002480 putative substrate binding pocket [chemical binding]; other site 516950002481 AC domain interface; other site 516950002482 catalytic triad [active] 516950002483 AB domain interface; other site 516950002484 interchain disulfide; other site 516950002485 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 516950002486 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 516950002487 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 516950002488 RNA binding site [nucleotide binding]; other site 516950002489 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 516950002490 RNA binding site [nucleotide binding]; other site 516950002491 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 516950002492 RNA binding site [nucleotide binding]; other site 516950002493 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 516950002494 RNA binding site [nucleotide binding]; other site 516950002495 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 516950002496 Transposase; Region: DDE_Tnp_ISL3; pfam01610 516950002497 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 516950002498 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 516950002499 GAF domain; Region: GAF_2; pfam13185 516950002500 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 516950002501 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 516950002502 Walker A motif; other site 516950002503 ATP binding site [chemical binding]; other site 516950002504 Walker B motif; other site 516950002505 arginine finger; other site 516950002506 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 516950002507 Protein of unknown function (DUF3272); Region: DUF3272; pfam11676 516950002508 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 516950002509 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 516950002510 Walker A/P-loop; other site 516950002511 ATP binding site [chemical binding]; other site 516950002512 Q-loop/lid; other site 516950002513 ABC transporter signature motif; other site 516950002514 Walker B; other site 516950002515 D-loop; other site 516950002516 H-loop/switch region; other site 516950002517 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 516950002518 FeS assembly protein SufD; Region: sufD; TIGR01981 516950002519 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 516950002520 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 516950002521 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 516950002522 catalytic residue [active] 516950002523 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 516950002524 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 516950002525 trimerization site [polypeptide binding]; other site 516950002526 active site 516950002527 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 516950002528 FeS assembly protein SufB; Region: sufB; TIGR01980 516950002529 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 516950002530 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 516950002531 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 516950002532 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 516950002533 Domain of unknown function DUF20; Region: UPF0118; pfam01594 516950002534 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 516950002535 Domain of unknown function DUF1829; Region: DUF1829; pfam08862 516950002536 TM2 domain; Region: TM2; pfam05154 516950002537 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 516950002538 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 516950002539 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 516950002540 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 516950002541 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 516950002542 putative substrate binding site [chemical binding]; other site 516950002543 putative ATP binding site [chemical binding]; other site 516950002544 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 516950002545 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 516950002546 active site 516950002547 phosphorylation site [posttranslational modification] 516950002548 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 516950002549 active site 516950002550 P-loop; other site 516950002551 phosphorylation site [posttranslational modification] 516950002552 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 516950002553 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 516950002554 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 516950002555 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 516950002556 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 516950002557 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 516950002558 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 516950002559 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 516950002560 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 516950002561 catalytic residue [active] 516950002562 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 516950002563 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 516950002564 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 516950002565 Ligand Binding Site [chemical binding]; other site 516950002566 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 516950002567 Putative esterase; Region: Esterase; pfam00756 516950002568 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 516950002569 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 516950002570 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 516950002571 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 516950002572 HsdM N-terminal domain; Region: HsdM_N; pfam12161 516950002573 Methyltransferase domain; Region: Methyltransf_26; pfam13659 516950002574 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 516950002575 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 516950002576 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 516950002577 Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877 516950002578 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 516950002579 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 516950002580 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495 516950002581 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 516950002582 active site 516950002583 catalytic residues [active] 516950002584 DNA binding site [nucleotide binding] 516950002585 Int/Topo IB signature motif; other site 516950002586 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 516950002587 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 516950002588 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 516950002589 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 516950002590 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 516950002591 ATP binding site [chemical binding]; other site 516950002592 putative Mg++ binding site [ion binding]; other site 516950002593 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 516950002594 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 516950002595 CAAX protease self-immunity; Region: Abi; pfam02517 516950002596 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 516950002597 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 516950002598 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 516950002599 putative active site [active] 516950002600 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 516950002601 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 516950002602 putative active site cavity [active] 516950002603 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 516950002604 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 516950002605 inhibitor site; inhibition site 516950002606 active site 516950002607 dimer interface [polypeptide binding]; other site 516950002608 catalytic residue [active] 516950002609 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 516950002610 Na binding site [ion binding]; other site 516950002611 Domain of unknown function (DUF386); Region: DUF386; pfam04074 516950002612 Neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: NanH; COG4409 516950002613 Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated...; Region: PTX; cl00102 516950002614 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 516950002615 Asp-box motif; other site 516950002616 catalytic site [active] 516950002617 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 516950002618 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 516950002619 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 516950002620 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 516950002621 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 516950002622 Archaeal/vacuolar-type H+-ATPase subunit I [Energy production and conversion]; Region: NtpI; COG1269 516950002623 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 516950002624 V-type ATP synthase subunit K; Validated; Region: PRK06558 516950002625 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 516950002626 ATP synthase subunit C; Region: ATP-synt_C; pfam00137 516950002627 Archaeal/vacuolar-type H+-ATPase subunit E [Energy production and conversion]; Region: NtpE; COG1390 516950002628 Archaeal/vacuolar-type H+-ATPase subunit C [Energy production and conversion]; Region: NtpC; COG1527 516950002629 V-type ATP synthase subunit C; Provisional; Region: PRK01198; cl00660 516950002630 V-type ATP synthase subunit F; Provisional; Region: PRK01395 516950002631 V-type ATP synthase subunit A; Provisional; Region: PRK04192 516950002632 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 516950002633 V/A-type ATP synthase catalytic subunit A. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_A; cd01134 516950002634 Walker A motif/ATP binding site; other site 516950002635 Walker B motif; other site 516950002636 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 516950002637 V-type ATP synthase subunit B; Provisional; Region: PRK04196 516950002638 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 516950002639 V/A-type ATP synthase (non-catalytic) subunit B. These ATPases couple ATP hydrolysis to the build up of a H+ gradient, but V-type ATPases do not catalyze the reverse reaction. The Vacuolar (V-type) ATPase is found in the membranes of vacuoles, the golgi...; Region: V_A-ATPase_B; cd01135 516950002640 Walker A motif homologous position; other site 516950002641 Walker B motif; other site 516950002642 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 516950002643 V-type ATP synthase subunit D; Reviewed; Region: PRK00373 516950002644 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 516950002645 Transposase; Region: DDE_Tnp_ISL3; pfam01610 516950002646 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 516950002647 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 516950002648 Q-loop/lid; other site 516950002649 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 516950002650 ABC transporter signature motif; other site 516950002651 Walker B; other site 516950002652 D-loop; other site 516950002653 H-loop/switch region; other site 516950002654 Arginine repressor [Transcription]; Region: ArgR; COG1438 516950002655 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 516950002656 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 516950002657 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 516950002658 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; pfam09168 516950002659 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 516950002660 DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279 516950002661 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 516950002662 active site 516950002663 PHP Thumb interface [polypeptide binding]; other site 516950002664 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 516950002665 generic binding surface II; other site 516950002666 generic binding surface I; other site 516950002667 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 516950002668 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 516950002669 active site 516950002670 ADP/pyrophosphate binding site [chemical binding]; other site 516950002671 dimerization interface [polypeptide binding]; other site 516950002672 allosteric effector site; other site 516950002673 fructose-1,6-bisphosphate binding site; other site 516950002674 pyruvate kinase; Provisional; Region: PRK05826 516950002675 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 516950002676 domain interfaces; other site 516950002677 active site 516950002678 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 516950002679 sequence-specific DNA binding site [nucleotide binding]; other site 516950002680 salt bridge; other site 516950002681 Domain of unknown function (DUF4300); Region: DUF4300; pfam14133 516950002682 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 516950002683 Predicted membrane protein [Function unknown]; Region: COG3689 516950002684 Predicted permeases [General function prediction only]; Region: COG0701 516950002685 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 516950002686 active site 516950002687 Exopolysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3955 516950002688 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 516950002689 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 516950002690 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 516950002691 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 516950002692 RNA binding site [nucleotide binding]; other site 516950002693 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 516950002694 hypothetical protein; Provisional; Region: PRK04351 516950002695 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 516950002696 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 516950002697 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 516950002698 Walker A/P-loop; other site 516950002699 ATP binding site [chemical binding]; other site 516950002700 Q-loop/lid; other site 516950002701 ABC transporter signature motif; other site 516950002702 Walker B; other site 516950002703 D-loop; other site 516950002704 H-loop/switch region; other site 516950002705 FtsX-like permease family; Region: FtsX; pfam02687 516950002706 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 516950002707 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 516950002708 Helix-turn-helix domain; Region: HTH_38; pfam13936 516950002709 Integrase core domain; Region: rve; pfam00665 516950002710 Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982 516950002711 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 516950002712 homodimer interface [polypeptide binding]; other site 516950002713 pyridoxal 5'-phosphate binding site [chemical binding]; other site 516950002714 catalytic residue [active] 516950002715 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 516950002716 Transposase; Region: DEDD_Tnp_IS110; pfam01548 516950002717 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 516950002718 spermidine synthase; Provisional; Region: PRK00811 516950002719 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 516950002720 S-adenosylmethionine binding site [chemical binding]; other site 516950002721 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 516950002722 Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; pfam01488 516950002723 carboxynorspermidine decarboxylase; Region: nspC; TIGR01047 516950002724 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829 516950002725 dimer interface [polypeptide binding]; other site 516950002726 active site 516950002727 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 516950002728 catalytic residues [active] 516950002729 substrate binding site [chemical binding]; other site 516950002730 agmatine deiminase; Provisional; Region: PRK13551 516950002731 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 516950002732 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 516950002733 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 516950002734 putative active site; other site 516950002735 catalytic triad [active] 516950002736 putative dimer interface [polypeptide binding]; other site 516950002737 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 516950002738 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 516950002739 active site 516950002740 motif I; other site 516950002741 motif II; other site 516950002742 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 516950002743 CAAX protease self-immunity; Region: Abi; pfam02517 516950002744 Transcriptional regulator [Transcription]; Region: LysR; COG0583 516950002745 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 516950002746 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 516950002747 dimerization interface [polypeptide binding]; other site 516950002748 lipoprotein signal peptidase; Provisional; Region: PRK14797 516950002749 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 516950002750 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 516950002751 RNA binding surface [nucleotide binding]; other site 516950002752 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 516950002753 active site 516950002754 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 516950002755 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 516950002756 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 516950002757 Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263 516950002758 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 516950002759 nucleotide binding site [chemical binding]; other site 516950002760 homotetrameric interface [polypeptide binding]; other site 516950002761 putative phosphate binding site [ion binding]; other site 516950002762 putative allosteric binding site; other site 516950002763 PUA domain; Region: PUA; pfam01472 516950002764 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 516950002765 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 516950002766 putative catalytic cysteine [active] 516950002767 pyrroline-5-carboxylate reductase; Region: PLN02688 516950002768 pyrroline-5-carboxylate reductase; Region: proC; TIGR00112 516950002769 thymidylate kinase; Validated; Region: tmk; PRK00698 516950002770 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 516950002771 TMP-binding site; other site 516950002772 ATP-binding site [chemical binding]; other site 516950002773 DNA polymerase III subunit delta'; Validated; Region: PRK07276 516950002774 DNA polymerase III subunit delta'; Validated; Region: PRK08485 516950002775 DNA replication intiation control protein YabA; Reviewed; Region: PRK13169 516950002776 Predicted methyltransferases [General function prediction only]; Region: COG0313 516950002777 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 516950002778 putative SAM binding site [chemical binding]; other site 516950002779 putative homodimer interface [polypeptide binding]; other site 516950002780 Uncharacterized conserved protein [Function unknown]; Region: COG4283 516950002781 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 516950002782 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 516950002783 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 516950002784 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 516950002785 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 516950002786 Glucose inhibited division protein A; Region: GIDA; pfam01134 516950002787 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 516950002788 putative nucleotide binding site [chemical binding]; other site 516950002789 uridine monophosphate binding site [chemical binding]; other site 516950002790 homohexameric interface [polypeptide binding]; other site 516950002791 ribosome recycling factor; Reviewed; Region: frr; PRK00083 516950002792 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 516950002793 hinge region; other site 516950002794 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 516950002795 S1 domain; Region: S1_2; pfam13509 516950002796 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 516950002797 hypothetical protein; Provisional; Region: PRK13672 516950002798 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 516950002799 PhoH-like protein; Region: PhoH; pfam02562 516950002800 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 516950002801 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 516950002802 DDE superfamily endonuclease; Region: DDE_4; cl17710 516950002803 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 516950002804 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 516950002805 Coenzyme A binding pocket [chemical binding]; other site 516950002806 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 516950002807 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 516950002808 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 516950002809 hexamer interface [polypeptide binding]; other site 516950002810 ligand binding site [chemical binding]; other site 516950002811 putative active site [active] 516950002812 NAD(P) binding site [chemical binding]; other site 516950002813 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 516950002814 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 516950002815 SLBB domain; Region: SLBB; pfam10531 516950002816 comEA protein; Region: comE; TIGR01259 516950002817 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786 516950002818 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 516950002819 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 516950002820 Competence protein; Region: Competence; pfam03772 516950002821 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 516950002822 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 516950002823 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13541 516950002824 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 516950002825 Walker A/P-loop; other site 516950002826 ATP binding site [chemical binding]; other site 516950002827 Q-loop/lid; other site 516950002828 ABC transporter signature motif; other site 516950002829 Walker B; other site 516950002830 D-loop; other site 516950002831 H-loop/switch region; other site 516950002832 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 516950002833 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 516950002834 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 516950002835 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 516950002836 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 516950002837 23S rRNA binding site [nucleotide binding]; other site 516950002838 L21 binding site [polypeptide binding]; other site 516950002839 L13 binding site [polypeptide binding]; other site 516950002840 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 516950002841 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 516950002842 dimer interface [polypeptide binding]; other site 516950002843 active site 516950002844 metal binding site [ion binding]; metal-binding site 516950002845 glutathione binding site [chemical binding]; other site 516950002846 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 516950002847 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 516950002848 FAD binding pocket [chemical binding]; other site 516950002849 FAD binding motif [chemical binding]; other site 516950002850 phosphate binding motif [ion binding]; other site 516950002851 beta-alpha-beta structure motif; other site 516950002852 NAD binding pocket [chemical binding]; other site 516950002853 Iron coordination center [ion binding]; other site 516950002854 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 516950002855 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 516950002856 heterodimer interface [polypeptide binding]; other site 516950002857 active site 516950002858 FMN binding site [chemical binding]; other site 516950002859 homodimer interface [polypeptide binding]; other site 516950002860 substrate binding site [chemical binding]; other site 516950002861 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 516950002862 Beta- N-acetylglucosaminidase [Carbohydrate transport and metabolism]; Region: LytD; COG4193 516950002863 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 516950002864 Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293 516950002865 Domain of unknown function (DUF814); Region: DUF814; pfam05670 516950002866 metal-binding heat shock protein; Provisional; Region: PRK00016 516950002867 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 516950002868 GTPase Era; Reviewed; Region: era; PRK00089 516950002869 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 516950002870 G1 box; other site 516950002871 GTP/Mg2+ binding site [chemical binding]; other site 516950002872 Switch I region; other site 516950002873 G2 box; other site 516950002874 Switch II region; other site 516950002875 G3 box; other site 516950002876 G4 box; other site 516950002877 G5 box; other site 516950002878 KH domain; Region: KH_2; pfam07650 516950002879 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 516950002880 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 516950002881 DNA binding site [nucleotide binding] 516950002882 catalytic residue [active] 516950002883 H2TH interface [polypeptide binding]; other site 516950002884 putative catalytic residues [active] 516950002885 turnover-facilitating residue; other site 516950002886 intercalation triad [nucleotide binding]; other site 516950002887 8OG recognition residue [nucleotide binding]; other site 516950002888 putative reading head residues; other site 516950002889 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 516950002890 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 516950002891 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 516950002892 dephospho-CoA kinase; Region: TIGR00152 516950002893 CoA-binding site [chemical binding]; other site 516950002894 ATP-binding [chemical binding]; other site 516950002895 drug efflux system protein MdtG; Provisional; Region: PRK09874 516950002896 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 516950002897 putative substrate translocation pore; other site 516950002898 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 516950002899 ribonuclease R; Region: RNase_R; TIGR02063 516950002900 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 516950002901 RNB domain; Region: RNB; pfam00773 516950002902 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 516950002903 RNA binding site [nucleotide binding]; other site 516950002904 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 516950002905 SmpB-tmRNA interface; other site 516950002906 tellurite resistance protein TehB; Provisional; Region: PRK12335 516950002907 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 516950002908 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 516950002909 S-adenosylmethionine binding site [chemical binding]; other site 516950002910 Competence protein CoiA-like family, contains a predicted nuclease domain [General function prediction only]; Region: CoiA; COG4469 516950002911 Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164 516950002912 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 516950002913 active site 516950002914 Zn binding site [ion binding]; other site 516950002915 Predicted O-methyltransferase [General function prediction only]; Region: COG4122 516950002916 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 516950002917 S-adenosylmethionine binding site [chemical binding]; other site 516950002918 foldase protein PrsA; Reviewed; Region: prsA; PRK01326 516950002919 PPIC-type PPIASE domain; Region: Rotamase_2; cl08278 516950002920 Integrase core domain; Region: rve; pfam00665 516950002921 Integrase core domain; Region: rve_2; pfam13333 516950002922 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 516950002923 catalytic core [active] 516950002924 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 516950002925 putative deacylase active site [active] 516950002926 Predicted membrane protein [Function unknown]; Region: COG2035 516950002927 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 516950002928 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 516950002929 active site 516950002930 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 516950002931 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 516950002932 Substrate binding site; other site 516950002933 Mg++ binding site; other site 516950002934 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 516950002935 active site 516950002936 substrate binding site [chemical binding]; other site 516950002937 CoA binding site [chemical binding]; other site 516950002938 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 516950002939 dimer interface [polypeptide binding]; other site 516950002940 ADP-ribose binding site [chemical binding]; other site 516950002941 active site 516950002942 nudix motif; other site 516950002943 metal binding site [ion binding]; metal-binding site 516950002944 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 516950002945 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 516950002946 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 516950002947 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 516950002948 active site 516950002949 catalytic site [active] 516950002950 substrate binding site [chemical binding]; other site 516950002951 Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781 516950002952 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 516950002953 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 516950002954 putative active site [active] 516950002955 catalytic site [active] 516950002956 putative metal binding site [ion binding]; other site 516950002957 Helix-turn-helix domain; Region: HTH_28; pfam13518 516950002958 Winged helix-turn helix; Region: HTH_29; pfam13551 516950002959 DDE superfamily endonuclease; Region: DDE_3; pfam13358 516950002960 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 516950002961 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 516950002962 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 516950002963 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 516950002964 catalytic residues [active] 516950002965 amino acid transporter; Region: 2A0306; TIGR00909 516950002966 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 516950002967 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 516950002968 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 516950002969 metal binding site [ion binding]; metal-binding site 516950002970 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 516950002971 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 516950002972 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 516950002973 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 516950002974 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 516950002975 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 516950002976 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 516950002977 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 516950002978 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 516950002979 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 516950002980 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 516950002981 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 516950002982 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 516950002983 peptidase T; Region: peptidase-T; TIGR01882 516950002984 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 516950002985 metal binding site [ion binding]; metal-binding site 516950002986 dimer interface [polypeptide binding]; other site 516950002987 Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276 516950002988 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 516950002989 C-terminal domain interface [polypeptide binding]; other site 516950002990 active site 516950002991 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 516950002992 active site 516950002993 N-terminal domain interface [polypeptide binding]; other site 516950002994 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 516950002995 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 516950002996 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 516950002997 Predicted membrane protein [Function unknown]; Region: COG2246 516950002998 GtrA-like protein; Region: GtrA; pfam04138 516950002999 Predicted membrane protein [Function unknown]; Region: COG4708 516950003000 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 516950003001 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 516950003002 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 516950003003 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 516950003004 dimer interface [polypeptide binding]; other site 516950003005 active site 516950003006 catalytic residue [active] 516950003007 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 516950003008 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 516950003009 trmE is a tRNA modification GTPase; Region: trmE; cd04164 516950003010 G1 box; other site 516950003011 GTP/Mg2+ binding site [chemical binding]; other site 516950003012 Switch I region; other site 516950003013 G2 box; other site 516950003014 Switch II region; other site 516950003015 G3 box; other site 516950003016 G4 box; other site 516950003017 G5 box; other site 516950003018 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 516950003019 4-oxalocrotonate tautomerase; Provisional; Region: PRK02289 516950003020 active site 1 [active] 516950003021 dimer interface [polypeptide binding]; other site 516950003022 hexamer interface [polypeptide binding]; other site 516950003023 active site 2 [active] 516950003024 thymidine kinase; Provisional; Region: PRK04296 516950003025 peptide chain release factor 1; Validated; Region: prfA; PRK00591 516950003026 This domain is found in peptide chain release factors; Region: PCRF; smart00937 516950003027 RF-1 domain; Region: RF-1; pfam00472 516950003028 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 516950003029 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 516950003030 S-adenosylmethionine binding site [chemical binding]; other site 516950003031 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 516950003032 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 516950003033 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 516950003034 Coenzyme A binding pocket [chemical binding]; other site 516950003035 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 516950003036 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 516950003037 dimer interface [polypeptide binding]; other site 516950003038 active site 516950003039 glycine-pyridoxal phosphate binding site [chemical binding]; other site 516950003040 folate binding site [chemical binding]; other site 516950003041 37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473 516950003042 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 516950003043 Lysozyme-like; Region: Lysozyme_like; pfam13702 516950003044 catalytic residue [active] 516950003045 Predicted secreted protein [Function unknown]; Region: COG4086 516950003046 Protein of unknown function (DUF1002); Region: DUF1002; pfam06207 516950003047 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 516950003048 TRAM domain; Region: TRAM; cl01282 516950003049 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 516950003050 S-adenosylmethionine binding site [chemical binding]; other site 516950003051 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 516950003052 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 516950003053 siderophore binding site; other site 516950003054 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 516950003055 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 516950003056 ABC-ATPase subunit interface; other site 516950003057 dimer interface [polypeptide binding]; other site 516950003058 putative PBP binding regions; other site 516950003059 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 516950003060 ABC-ATPase subunit interface; other site 516950003061 dimer interface [polypeptide binding]; other site 516950003062 putative PBP binding regions; other site 516950003063 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 516950003064 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 516950003065 Walker A/P-loop; other site 516950003066 ATP binding site [chemical binding]; other site 516950003067 Q-loop/lid; other site 516950003068 ABC transporter signature motif; other site 516950003069 Walker B; other site 516950003070 D-loop; other site 516950003071 H-loop/switch region; other site 516950003072 Protein of unknown function (DUF3847); Region: DUF3847; pfam12958 516950003073 MobA/MobL family; Region: MobA_MobL; pfam03389 516950003074 chromosome segregation protein; Provisional; Region: PRK03918 516950003075 Protein of unknown function (DUF3801); Region: DUF3801; pfam12687 516950003076 N-terminal phage replisome organiser (Phage_rep_org_N); Region: Phage_rep_org_N; cl09889 516950003077 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 516950003078 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 516950003079 catalytic residues [active] 516950003080 catalytic nucleophile [active] 516950003081 Recombinase; Region: Recombinase; pfam07508 516950003082 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 516950003083 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 516950003084 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 516950003085 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 516950003086 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 516950003087 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 516950003088 homodimer interface [polypeptide binding]; other site 516950003089 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 516950003090 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 516950003091 active site 516950003092 homodimer interface [polypeptide binding]; other site 516950003093 catalytic site [active] 516950003094 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 516950003095 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 516950003096 non-specific DNA binding site [nucleotide binding]; other site 516950003097 salt bridge; other site 516950003098 sequence-specific DNA binding site [nucleotide binding]; other site 516950003099 Zeta toxin; Region: Zeta_toxin; pfam06414 516950003100 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 516950003101 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 516950003102 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 516950003103 ABC transporter signature motif; other site 516950003104 Walker B; other site 516950003105 D-loop; other site 516950003106 H-loop/switch region; other site 516950003107 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 516950003108 Lantibiotic streptin immunity protein; Region: Streptin-Immun; pfam11083 516950003109 Transposase domain (DUF772); Region: DUF772; pfam05598 516950003110 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 516950003111 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 516950003112 Helix-turn-helix domain; Region: HTH_38; pfam13936 516950003113 Integrase core domain; Region: rve; pfam00665 516950003114 Predicted membrane protein [Function unknown]; Region: COG1808 516950003115 DNA topoisomerase I; Validated; Region: PRK05582 516950003116 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 516950003117 active site 516950003118 interdomain interaction site; other site 516950003119 putative metal-binding site [ion binding]; other site 516950003120 nucleotide binding site [chemical binding]; other site 516950003121 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 516950003122 domain I; other site 516950003123 DNA binding groove [nucleotide binding] 516950003124 phosphate binding site [ion binding]; other site 516950003125 domain II; other site 516950003126 domain III; other site 516950003127 nucleotide binding site [chemical binding]; other site 516950003128 catalytic site [active] 516950003129 domain IV; other site 516950003130 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 516950003131 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 516950003132 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 516950003133 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832 516950003134 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 516950003135 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 516950003136 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 516950003137 metal binding site [ion binding]; metal-binding site 516950003138 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 516950003139 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 516950003140 tartrate dehydrogenase; Region: TTC; TIGR02089 516950003141 Predicted membrane protein [Function unknown]; Region: COG3326 516950003142 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 516950003143 substrate binding site [chemical binding]; other site 516950003144 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 516950003145 GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401 516950003146 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 516950003147 Walker A motif; other site 516950003148 ATP binding site [chemical binding]; other site 516950003149 McrBC 5-methylcytosine restriction system component [Defense mechanisms]; Region: McrC; COG4268 516950003150 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 516950003151 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 516950003152 active site 516950003153 ribonuclease III; Reviewed; Region: rnc; PRK00102 516950003154 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 516950003155 dimerization interface [polypeptide binding]; other site 516950003156 active site 516950003157 metal binding site [ion binding]; metal-binding site 516950003158 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 516950003159 dsRNA binding site [nucleotide binding]; other site 516950003160 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 516950003161 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 516950003162 Walker A/P-loop; other site 516950003163 ATP binding site [chemical binding]; other site 516950003164 Q-loop/lid; other site 516950003165 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 516950003166 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 516950003167 ABC transporter signature motif; other site 516950003168 Walker B; other site 516950003169 D-loop; other site 516950003170 H-loop/switch region; other site 516950003171 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 516950003172 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 516950003173 active site 516950003174 motif I; other site 516950003175 motif II; other site 516950003176 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 516950003177 sugar phosphate phosphatase; Provisional; Region: PRK10513 516950003178 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 516950003179 motif II; other site 516950003180 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 516950003181 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 516950003182 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 516950003183 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 516950003184 P loop; other site 516950003185 GTP binding site [chemical binding]; other site 516950003186 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 516950003187 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 516950003188 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 516950003189 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 516950003190 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 516950003191 Walker A/P-loop; other site 516950003192 ATP binding site [chemical binding]; other site 516950003193 Q-loop/lid; other site 516950003194 ABC transporter signature motif; other site 516950003195 Walker B; other site 516950003196 D-loop; other site 516950003197 H-loop/switch region; other site 516950003198 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 516950003199 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 516950003200 substrate binding pocket [chemical binding]; other site 516950003201 membrane-bound complex binding site; other site 516950003202 hinge residues; other site 516950003203 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 516950003204 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 516950003205 substrate binding pocket [chemical binding]; other site 516950003206 membrane-bound complex binding site; other site 516950003207 hinge residues; other site 516950003208 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 516950003209 dimer interface [polypeptide binding]; other site 516950003210 conserved gate region; other site 516950003211 putative PBP binding loops; other site 516950003212 ABC-ATPase subunit interface; other site 516950003213 CAAX protease self-immunity; Region: Abi; pfam02517 516950003214 excinuclease ABC subunit B; Provisional; Region: PRK05298 516950003215 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 516950003216 ATP binding site [chemical binding]; other site 516950003217 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 516950003218 nucleotide binding region [chemical binding]; other site 516950003219 ATP-binding site [chemical binding]; other site 516950003220 Ultra-violet resistance protein B; Region: UvrB; pfam12344 516950003221 UvrB/uvrC motif; Region: UVR; pfam02151 516950003222 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 516950003223 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 516950003224 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 516950003225 Coenzyme A binding pocket [chemical binding]; other site 516950003226 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 516950003227 putative active site [active] 516950003228 nucleotide binding site [chemical binding]; other site 516950003229 nudix motif; other site 516950003230 putative metal binding site [ion binding]; other site 516950003231 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 516950003232 HTH domain; Region: HTH_11; pfam08279 516950003233 3H domain; Region: 3H; pfam02829 516950003234 Predicted membrane protein [Function unknown]; Region: COG4684 516950003235 phosphopantothenoylcysteine decarboxylase, streptococcal; Region: coaC_strep; TIGR02113 516950003236 Flavoprotein; Region: Flavoprotein; pfam02441 516950003237 phosphopantothenate--cysteine ligase; Validated; Region: PRK06732 516950003238 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 516950003239 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 516950003240 Potassium binding sites [ion binding]; other site 516950003241 Cesium cation binding sites [ion binding]; other site 516950003242 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 516950003243 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 516950003244 minor groove reading motif; other site 516950003245 helix-hairpin-helix signature motif; other site 516950003246 substrate binding pocket [chemical binding]; other site 516950003247 active site 516950003248 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 516950003249 DNA binding and oxoG recognition site [nucleotide binding] 516950003250 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 516950003251 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 516950003252 active site 516950003253 phosphorylation site [posttranslational modification] 516950003254 intermolecular recognition site; other site 516950003255 dimerization interface [polypeptide binding]; other site 516950003256 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 516950003257 DNA binding site [nucleotide binding] 516950003258 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 516950003259 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 516950003260 putative active site [active] 516950003261 heme pocket [chemical binding]; other site 516950003262 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 516950003263 dimer interface [polypeptide binding]; other site 516950003264 phosphorylation site [posttranslational modification] 516950003265 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 516950003266 ATP binding site [chemical binding]; other site 516950003267 Mg2+ binding site [ion binding]; other site 516950003268 G-X-G motif; other site 516950003269 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 516950003270 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 516950003271 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 516950003272 Ion channel; Region: Ion_trans_2; pfam07885 516950003273 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 516950003274 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 516950003275 tetramer (dimer of dimers) interface [polypeptide binding]; other site 516950003276 NAD binding site [chemical binding]; other site 516950003277 dimer interface [polypeptide binding]; other site 516950003278 substrate binding site [chemical binding]; other site 516950003279 DNA gyrase subunit A; Validated; Region: PRK05560 516950003280 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 516950003281 CAP-like domain; other site 516950003282 active site 516950003283 primary dimer interface [polypeptide binding]; other site 516950003284 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 516950003285 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 516950003286 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 516950003287 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 516950003288 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 516950003289 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 516950003290 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 516950003291 active site 516950003292 catalytic site [active] 516950003293 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 516950003294 Dppa2/4 conserved region; Region: DCR; pfam14047 516950003295 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 516950003296 hypothetical protein; Provisional; Region: PRK05939 516950003297 homodimer interface [polypeptide binding]; other site 516950003298 substrate-cofactor binding pocket; other site 516950003299 pyridoxal 5'-phosphate binding site [chemical binding]; other site 516950003300 catalytic residue [active] 516950003301 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487 516950003302 Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903 516950003303 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 516950003304 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484 516950003305 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 516950003306 RNA binding site [nucleotide binding]; other site 516950003307 active site 516950003308 tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142 516950003309 Enterocin A Immunity; Region: EntA_Immun; pfam08951 516950003310 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 516950003311 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 516950003312 Sugar specificity; other site 516950003313 Pyrimidine base specificity; other site 516950003314 ATP-binding site [chemical binding]; other site 516950003315 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 516950003316 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 516950003317 generic binding surface II; other site 516950003318 generic binding surface I; other site 516950003319 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 516950003320 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 516950003321 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 516950003322 substrate binding pocket [chemical binding]; other site 516950003323 chain length determination region; other site 516950003324 substrate-Mg2+ binding site; other site 516950003325 catalytic residues [active] 516950003326 aspartate-rich region 1; other site 516950003327 active site lid residues [active] 516950003328 aspartate-rich region 2; other site 516950003329 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 516950003330 S4 RNA-binding domain; Region: S4; smart00363 516950003331 RNA binding surface [nucleotide binding]; other site 516950003332 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 516950003333 Arginine repressor [Transcription]; Region: ArgR; COG1438 516950003334 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 516950003335 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 516950003336 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 516950003337 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 516950003338 Walker A/P-loop; other site 516950003339 ATP binding site [chemical binding]; other site 516950003340 Q-loop/lid; other site 516950003341 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 516950003342 ABC transporter signature motif; other site 516950003343 Walker B; other site 516950003344 D-loop; other site 516950003345 H-loop/switch region; other site 516950003346 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 516950003347 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 516950003348 active site 516950003349 metal binding site [ion binding]; metal-binding site 516950003350 GTP-binding protein LepA; Provisional; Region: PRK05433 516950003351 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 516950003352 G1 box; other site 516950003353 putative GEF interaction site [polypeptide binding]; other site 516950003354 GTP/Mg2+ binding site [chemical binding]; other site 516950003355 Switch I region; other site 516950003356 G2 box; other site 516950003357 G3 box; other site 516950003358 Switch II region; other site 516950003359 G4 box; other site 516950003360 G5 box; other site 516950003361 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 516950003362 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 516950003363 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 516950003364 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 516950003365 active site 516950003366 phosphorylation site [posttranslational modification] 516950003367 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 516950003368 active site 516950003369 P-loop; other site 516950003370 phosphorylation site [posttranslational modification] 516950003371 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 516950003372 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 516950003373 aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648 516950003374 catalytic residues [active] 516950003375 galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621 516950003376 galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622 516950003377 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 516950003378 tagatose-6-phosphate kinase; Region: lacC; TIGR01231 516950003379 putative substrate binding site [chemical binding]; other site 516950003380 putative ATP binding site [chemical binding]; other site 516950003381 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 516950003382 CAT RNA binding domain; Region: CAT_RBD; smart01061 516950003383 transcriptional antiterminator BglG; Provisional; Region: PRK09772 516950003384 PRD domain; Region: PRD; pfam00874 516950003385 PRD domain; Region: PRD; pfam00874 516950003386 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 516950003387 methionine cluster; other site 516950003388 active site 516950003389 phosphorylation site [posttranslational modification] 516950003390 metal binding site [ion binding]; metal-binding site 516950003391 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295 516950003392 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 516950003393 PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565 516950003394 active site 516950003395 P-loop; other site 516950003396 phosphorylation site [posttranslational modification] 516950003397 6-phospho-beta-galactosidase; Provisional; Region: PRK13511 516950003398 beta-galactosidase; Region: BGL; TIGR03356 516950003399 Protein of unknown function (DUF3884); Region: DUF3884; pfam13024 516950003400 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 516950003401 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 516950003402 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 516950003403 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 516950003404 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 516950003405 Transposase; Region: DDE_Tnp_ISL3; pfam01610 516950003406 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 516950003407 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 516950003408 dimer interface [polypeptide binding]; other site 516950003409 putative radical transfer pathway; other site 516950003410 diiron center [ion binding]; other site 516950003411 tyrosyl radical; other site 516950003412 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 516950003413 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 516950003414 Class I ribonucleotide reductase; Region: RNR_I; cd01679 516950003415 active site 516950003416 dimer interface [polypeptide binding]; other site 516950003417 catalytic residues [active] 516950003418 effector binding site; other site 516950003419 R2 peptide binding site; other site 516950003420 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 516950003421 catalytic residues [active] 516950003422 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 516950003423 dimerization domain swap beta strand [polypeptide binding]; other site 516950003424 regulatory protein interface [polypeptide binding]; other site 516950003425 active site 516950003426 regulatory phosphorylation site [posttranslational modification]; other site 516950003427 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 516950003428 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 516950003429 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 516950003430 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 516950003431 streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363 516950003432 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 516950003433 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 516950003434 Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270 516950003435 PLD-like domain; Region: PLDc_2; pfam13091 516950003436 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cd00138 516950003437 putative active site [active] 516950003438 catalytic site [active] 516950003439 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 516950003440 FRG domain; Region: FRG; pfam08867 516950003441 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 516950003442 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 516950003443 motif II; other site 516950003444 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 516950003445 ligand binding site [chemical binding]; other site 516950003446 active site 516950003447 UGI interface [polypeptide binding]; other site 516950003448 catalytic site [active] 516950003449 MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427 516950003450 putative active site [active] 516950003451 nucleotide binding site [chemical binding]; other site 516950003452 nudix motif; other site 516950003453 putative metal binding site [ion binding]; other site 516950003454 dihydroorotase; Validated; Region: pyrC; PRK09357 516950003455 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 516950003456 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 516950003457 active site 516950003458 multidrug efflux protein; Reviewed; Region: PRK01766 516950003459 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 516950003460 cation binding site [ion binding]; other site 516950003461 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071 516950003462 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 516950003463 tetramer interface [polypeptide binding]; other site 516950003464 TPP-binding site [chemical binding]; other site 516950003465 heterodimer interface [polypeptide binding]; other site 516950003466 phosphorylation loop region [posttranslational modification] 516950003467 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 516950003468 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 516950003469 alpha subunit interface [polypeptide binding]; other site 516950003470 TPP binding site [chemical binding]; other site 516950003471 heterodimer interface [polypeptide binding]; other site 516950003472 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 516950003473 dihydrolipoamide acetyltransferase; Provisional; Region: PRK14843 516950003474 e3 binding domain; Region: E3_binding; pfam02817 516950003475 e3 binding domain; Region: E3_binding; pfam02817 516950003476 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 516950003477 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 516950003478 E3 interaction surface; other site 516950003479 lipoyl attachment site [posttranslational modification]; other site 516950003480 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 516950003481 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 516950003482 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 516950003483 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 516950003484 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 516950003485 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 516950003486 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 516950003487 site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084 516950003488 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 516950003489 active site 516950003490 DNA binding site [nucleotide binding] 516950003491 Int/Topo IB signature motif; other site 516950003492 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 516950003493 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 516950003494 Cl- selectivity filter; other site 516950003495 Cl- binding residues [ion binding]; other site 516950003496 pore gating glutamate residue; other site 516950003497 dimer interface [polypeptide binding]; other site 516950003498 H+/Cl- coupling transport residue; other site 516950003499 TrkA-C domain; Region: TrkA_C; pfam02080 516950003500 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 516950003501 RNA/DNA hybrid binding site [nucleotide binding]; other site 516950003502 active site 516950003503 GTPase YlqF; Reviewed; Region: rbgA; PRK09563 516950003504 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 516950003505 GTP/Mg2+ binding site [chemical binding]; other site 516950003506 G4 box; other site 516950003507 G5 box; other site 516950003508 G1 box; other site 516950003509 Switch I region; other site 516950003510 G2 box; other site 516950003511 G3 box; other site 516950003512 Switch II region; other site 516950003513 G5 domain; Region: G5; pfam07501 516950003514 M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342 516950003515 M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580 516950003516 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 516950003517 G5 domain; Region: G5; pfam07501 516950003518 M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342 516950003519 M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580 516950003520 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 516950003521 Part of AAA domain; Region: AAA_19; pfam13245 516950003522 Family description; Region: UvrD_C_2; pfam13538 516950003523 Family description; Region: UvrD_C_2; pfam13538 516950003524 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 516950003525 ATP-dependent nuclease subunit B; Region: rexB_recomb; TIGR02774 516950003526 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 516950003527 Helix-turn-helix domain; Region: HTH_28; pfam13518 516950003528 Winged helix-turn helix; Region: HTH_29; pfam13551 516950003529 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 516950003530 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 516950003531 Transposase; Region: DDE_Tnp_ISL3; pfam01610 516950003532 enolase; Provisional; Region: eno; PRK00077 516950003533 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 516950003534 dimer interface [polypeptide binding]; other site 516950003535 metal binding site [ion binding]; metal-binding site 516950003536 substrate binding pocket [chemical binding]; other site 516950003537 Uncharacterized conserved protein [Function unknown]; Region: COG5506 516950003538 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 516950003539 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 516950003540 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 516950003541 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 516950003542 glycogen synthase; Provisional; Region: glgA; PRK00654 516950003543 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 516950003544 ADP-binding pocket [chemical binding]; other site 516950003545 homodimer interface [polypeptide binding]; other site 516950003546 glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092 516950003547 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 516950003548 active site 516950003549 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 516950003550 dimer interface [polypeptide binding]; other site 516950003551 N-terminal domain interface [polypeptide binding]; other site 516950003552 sulfate 1 binding site; other site 516950003553 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293 516950003554 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 516950003555 ligand binding site; other site 516950003556 oligomer interface; other site 516950003557 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 516950003558 dimer interface [polypeptide binding]; other site 516950003559 N-terminal domain interface [polypeptide binding]; other site 516950003560 sulfate 1 binding site; other site 516950003561 glycogen branching enzyme; Provisional; Region: PRK12313 516950003562 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 516950003563 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 516950003564 active site 516950003565 catalytic site [active] 516950003566 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 516950003567 NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082 516950003568 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412 516950003569 tetrameric interface [polypeptide binding]; other site 516950003570 activator binding site; other site 516950003571 NADP binding site [chemical binding]; other site 516950003572 substrate binding site [chemical binding]; other site 516950003573 catalytic residues [active] 516950003574 Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cl04227 516950003575 pullulanase, type I; Region: pulA_typeI; TIGR02104 516950003576 Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860 516950003577 Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341 516950003578 Ca binding site [ion binding]; other site 516950003579 active site 516950003580 catalytic site [active] 516950003581 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 516950003582 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 516950003583 nucleotide binding pocket [chemical binding]; other site 516950003584 K-X-D-G motif; other site 516950003585 catalytic site [active] 516950003586 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 516950003587 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 516950003588 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 516950003589 Dimer interface [polypeptide binding]; other site 516950003590 BRCT sequence motif; other site 516950003591 H+ Antiporter protein; Region: 2A0121; TIGR00900 516950003592 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 516950003593 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 516950003594 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 516950003595 non-specific DNA binding site [nucleotide binding]; other site 516950003596 salt bridge; other site 516950003597 sequence-specific DNA binding site [nucleotide binding]; other site 516950003598 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 516950003599 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 516950003600 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 516950003601 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 516950003602 ABC transporter; Region: ABC_tran_2; pfam12848 516950003603 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 516950003604 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 516950003605 IHF dimer interface [polypeptide binding]; other site 516950003606 IHF - DNA interface [nucleotide binding]; other site 516950003607 EDD domain protein, DegV family; Region: DegV; TIGR00762 516950003608 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 516950003609 Uncharacterized conserved protein [Function unknown]; Region: COG1284 516950003610 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 516950003611 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 516950003612 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 516950003613 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 516950003614 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 516950003615 active site 516950003616 Riboflavin kinase; Region: Flavokinase; smart00904 516950003617 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 516950003618 Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868 516950003619 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 516950003620 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 516950003621 Predicted membrane protein [Function unknown]; Region: COG3619 516950003622 hypothetical protein; Validated; Region: PRK00153 516950003623 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 516950003624 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 516950003625 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 516950003626 RNA binding surface [nucleotide binding]; other site 516950003627 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 516950003628 active site 516950003629 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 516950003630 ATP-NAD kinase; Region: NAD_kinase; pfam01513 516950003631 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 516950003632 synthetase active site [active] 516950003633 NTP binding site [chemical binding]; other site 516950003634 metal binding site [ion binding]; metal-binding site 516950003635 Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762 516950003636 putative active site [active] 516950003637 putative metal binding residues [ion binding]; other site 516950003638 signature motif; other site 516950003639 putative triphosphate binding site [ion binding]; other site 516950003640 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458 516950003641 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 516950003642 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 516950003643 active site 516950003644 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 516950003645 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 516950003646 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 516950003647 catalytic residue [active] 516950003648 Putative amino acid metabolism; Region: DUF1831; pfam08866 516950003649 AT-rich DNA-binding protein [General function prediction only]; Region: COG2344 516950003650 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 516950003651 CoA binding domain; Region: CoA_binding; pfam02629 516950003652 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 516950003653 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 516950003654 catalytic triad [active] 516950003655 hypothetical protein; Reviewed; Region: PRK00024 516950003656 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 516950003657 MPN+ (JAMM) motif; other site 516950003658 Zinc-binding site [ion binding]; other site 516950003659 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 516950003660 Part of AAA domain; Region: AAA_19; pfam13245 516950003661 Family description; Region: UvrD_C_2; pfam13538 516950003662 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 516950003663 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 516950003664 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 516950003665 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 516950003666 active site 516950003667 Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109 516950003668 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 516950003669 DNA-binding site [nucleotide binding]; DNA binding site 516950003670 DRTGG domain; Region: DRTGG; pfam07085 516950003671 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596 516950003672 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440 516950003673 active site 2 [active] 516950003674 active site 1 [active] 516950003675 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 516950003676 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 516950003677 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 516950003678 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 516950003679 hinge; other site 516950003680 active site 516950003681 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 516950003682 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 516950003683 Transposase; Region: DDE_Tnp_ISL3; pfam01610 516950003684 GTPase CgtA; Reviewed; Region: obgE; PRK12297 516950003685 GTP1/OBG; Region: GTP1_OBG; pfam01018 516950003686 Obg GTPase; Region: Obg; cd01898 516950003687 G1 box; other site 516950003688 GTP/Mg2+ binding site [chemical binding]; other site 516950003689 Switch I region; other site 516950003690 G2 box; other site 516950003691 G3 box; other site 516950003692 Switch II region; other site 516950003693 G4 box; other site 516950003694 G5 box; other site 516950003695 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 516950003696 Protein of unknown function (DUF4044); Region: DUF4044; pfam13253 516950003697 Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983 516950003698 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 516950003699 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 516950003700 putative ADP-binding pocket [chemical binding]; other site 516950003701 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 516950003702 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 516950003703 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 516950003704 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 516950003705 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 516950003706 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 516950003707 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 516950003708 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 516950003709 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 516950003710 DNA binding residues [nucleotide binding] 516950003711 DNA primase; Validated; Region: dnaG; PRK05667 516950003712 CHC2 zinc finger; Region: zf-CHC2; pfam01807 516950003713 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 516950003714 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 516950003715 active site 516950003716 metal binding site [ion binding]; metal-binding site 516950003717 interdomain interaction site; other site 516950003718 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 516950003719 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 516950003720 Walker A/P-loop; other site 516950003721 ATP binding site [chemical binding]; other site 516950003722 Q-loop/lid; other site 516950003723 ABC transporter signature motif; other site 516950003724 Walker B; other site 516950003725 D-loop; other site 516950003726 H-loop/switch region; other site 516950003727 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 516950003728 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 516950003729 TM-ABC transporter signature motif; other site 516950003730 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 516950003731 zinc binding site [ion binding]; other site 516950003732 putative ligand binding site [chemical binding]; other site 516950003733 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 516950003734 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 516950003735 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 516950003736 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 516950003737 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 516950003738 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 516950003739 conserved cys residue [active] 516950003740 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 516950003741 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 516950003742 catalytic residues [active] 516950003743 catalytic nucleophile [active] 516950003744 Recombinase; Region: Recombinase; pfam07508 516950003745 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 516950003746 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 516950003747 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 516950003748 non-specific DNA binding site [nucleotide binding]; other site 516950003749 salt bridge; other site 516950003750 sequence-specific DNA binding site [nucleotide binding]; other site 516950003751 Transposase; Region: DEDD_Tnp_IS110; pfam01548 516950003752 Transposase; Region: DEDD_Tnp_IS110; pfam01548 516950003753 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 516950003754 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG3694 516950003755 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 516950003756 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 516950003757 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 516950003758 ABC transporter signature motif; other site 516950003759 Walker B; other site 516950003760 D-loop; other site 516950003761 H-loop/switch region; other site 516950003762 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 516950003763 Walker A/P-loop; other site 516950003764 ATP binding site [chemical binding]; other site 516950003765 Q-loop/lid; other site 516950003766 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 516950003767 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 516950003768 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 516950003769 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 516950003770 active site 516950003771 HIGH motif; other site 516950003772 KMSKS motif; other site 516950003773 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 516950003774 tRNA binding surface [nucleotide binding]; other site 516950003775 anticodon binding site; other site 516950003776 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 516950003777 Chloramphenicol acetyltransferase; Region: CAT; cl02008 516950003778 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 516950003779 Helix-turn-helix domain; Region: HTH_38; pfam13936 516950003780 Integrase core domain; Region: rve; pfam00665 516950003781 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 516950003782 DNA protecting protein DprA; Region: dprA; TIGR00732 516950003783 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 516950003784 Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523 516950003785 active site 516950003786 metal-binding site 516950003787 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 516950003788 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 516950003789 Phosphotransferase enzyme family; Region: APH; pfam01636 516950003790 active site 516950003791 substrate binding site [chemical binding]; other site 516950003792 ATP binding site [chemical binding]; other site 516950003793 dimer interface [polypeptide binding]; other site 516950003794 ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237 516950003795 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 516950003796 putative NAD(P) binding site [chemical binding]; other site 516950003797 putative catalytic Zn binding site [ion binding]; other site 516950003798 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 516950003799 substrate binding site; other site 516950003800 dimer interface; other site 516950003801 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 516950003802 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 516950003803 LPS biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3475 516950003804 LPS biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3475 516950003805 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 516950003806 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 516950003807 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 516950003808 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 516950003809 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 516950003810 ATP-grasp domain; Region: ATP-grasp_4; cl17255 516950003811 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 516950003812 IMP binding site; other site 516950003813 dimer interface [polypeptide binding]; other site 516950003814 interdomain contacts; other site 516950003815 partial ornithine binding site; other site 516950003816 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 516950003817 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 516950003818 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 516950003819 catalytic site [active] 516950003820 subunit interface [polypeptide binding]; other site 516950003821 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 516950003822 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 516950003823 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 516950003824 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 516950003825 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 516950003826 active site 516950003827 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 516950003828 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 516950003829 minor groove reading motif; other site 516950003830 helix-hairpin-helix signature motif; other site 516950003831 substrate binding pocket [chemical binding]; other site 516950003832 active site 516950003833 Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399 516950003834 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 516950003835 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 516950003836 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 516950003837 heat shock protein HtpX; Provisional; Region: PRK04897 516950003838 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 516950003839 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 516950003840 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 516950003841 S-adenosylmethionine binding site [chemical binding]; other site 516950003842 uracil transporter; Provisional; Region: PRK10720 516950003843 signal recognition particle protein; Provisional; Region: PRK10867 516950003844 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 516950003845 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 516950003846 P loop; other site 516950003847 GTP binding site [chemical binding]; other site 516950003848 Signal peptide binding domain; Region: SRP_SPB; pfam02978 516950003849 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 516950003850 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 516950003851 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 516950003852 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 516950003853 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 516950003854 Zn2+ binding site [ion binding]; other site 516950003855 Mg2+ binding site [ion binding]; other site 516950003856 sugar phosphate phosphatase; Provisional; Region: PRK10513 516950003857 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 516950003858 active site 516950003859 motif I; other site 516950003860 motif II; other site 516950003861 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 516950003862 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 516950003863 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 516950003864 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 516950003865 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 516950003866 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 516950003867 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 516950003868 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 516950003869 Caspase domain; Region: Peptidase_C14; pfam00656 516950003870 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 516950003871 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 516950003872 non-specific DNA binding site [nucleotide binding]; other site 516950003873 salt bridge; other site 516950003874 sequence-specific DNA binding site [nucleotide binding]; other site 516950003875 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 516950003876 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 516950003877 camphor resistance protein CrcB; Provisional; Region: PRK14229 516950003878 camphor resistance protein CrcB; Provisional; Region: PRK14221 516950003879 hypothetical protein; Provisional; Region: PRK07248 516950003880 flavodoxin; Validated; Region: PRK07308 516950003881 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 516950003882 DHH family; Region: DHH; pfam01368 516950003883 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 516950003884 Dyp-type peroxidase family; Region: Dyp_perox; cl01067 516950003885 glutamate dehydrogenase; Provisional; Region: PRK09414 516950003886 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 516950003887 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 516950003888 NAD(P) binding site [chemical binding]; other site 516950003889 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 516950003890 Walker A motif; other site 516950003891 ATP binding site [chemical binding]; other site 516950003892 Walker B motif; other site 516950003893 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 516950003894 Int/Topo IB signature motif; other site 516950003895 Domain of unknown function (DUF3173); Region: DUF3173; pfam11372 516950003896 Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432 516950003897 Bacterial mobilisation protein (MobC); Region: MobC; pfam05713 516950003898 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 516950003899 Part of AAA domain; Region: AAA_19; pfam13245 516950003900 Family description; Region: UvrD_C_2; pfam13538 516950003901 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 516950003902 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 516950003903 Predicted transcriptional regulator [Transcription]; Region: COG2378 516950003904 WYL domain; Region: WYL; pfam13280 516950003905 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 516950003906 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 516950003907 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 516950003908 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 516950003909 active site 516950003910 motif I; other site 516950003911 motif II; other site 516950003912 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 516950003913 HD domain; Region: HD_4; pfam13328 516950003914 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 516950003915 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 516950003916 Replication protein; Region: Rep_1; cl02412 516950003917 Chloramphenicol acetyltransferase; Region: CAT; pfam00302 516950003918 Chloramphenicol O-acetyltransferase [Defense mechanisms]; Region: COG4845 516950003919 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 516950003920 GIY-YIG motif/motif A; other site 516950003921 active site 516950003922 catalytic site [active] 516950003923 Zeta toxin; Region: Zeta_toxin; pfam06414 516950003924 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 516950003925 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 516950003926 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 516950003927 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 516950003928 non-specific DNA binding site [nucleotide binding]; other site 516950003929 salt bridge; other site 516950003930 sequence-specific DNA binding site [nucleotide binding]; other site 516950003931 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 516950003932 Protein of unknown function (DUF3991); Region: DUF3991; pfam13154 516950003933 Toprim-like; Region: Toprim_2; pfam13155 516950003934 heptad repeat 1-heptad repeat 2 region (ectodomain) of the transmembrane subunit of various endogenous retroviruses (ERVs) and infectious retroviruses, including Ebola virus and human immunodeficiency virus type 1 (HIV-1); Region: Ebola_HIV-1-like_HR1-HR2; cl02885 516950003935 HR1; other site 516950003936 homotrimer interface [polypeptide binding]; other site 516950003937 immunosuppressive region; other site 516950003938 Methyltransferase domain; Region: Methyltransf_26; pfam13659 516950003939 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 516950003940 DEAD-like helicases superfamily; Region: DEXDc; smart00487 516950003941 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 516950003942 DNA methylase [Transcription / DNA replication, recombination, and repair]; Region: COG4646 516950003943 helicase superfamily c-terminal domain; Region: HELICc; smart00490 516950003944 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 516950003945 Peptidase family M23; Region: Peptidase_M23; pfam01551 516950003946 CHAP domain; Region: CHAP; pfam05257 516950003947 AAA-like domain; Region: AAA_10; pfam12846 516950003948 PrgI family protein; Region: PrgI; pfam12666 516950003949 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; cl01503 516950003950 AAA-like domain; Region: AAA_10; pfam12846 516950003951 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 516950003952 Walker A motif; other site 516950003953 ATP binding site [chemical binding]; other site 516950003954 Walker B motif; other site 516950003955 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 516950003956 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 516950003957 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 516950003958 Bacterial protein of unknown function (DUF961); Region: DUF961; pfam06125 516950003959 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 516950003960 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 516950003961 Walker A motif; other site 516950003962 ATP binding site [chemical binding]; other site 516950003963 Walker B motif; other site 516950003964 arginine finger; other site 516950003965 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 516950003966 non-specific DNA binding site [nucleotide binding]; other site 516950003967 salt bridge; other site 516950003968 sequence-specific DNA binding site [nucleotide binding]; other site 516950003969 Replication initiation factor; Region: Rep_trans; pfam02486 516950003970 Omega Transcriptional Repressor; Region: Omega_Repress; pfam07764 516950003971 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 516950003972 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 516950003973 S-adenosylmethionine binding site [chemical binding]; other site 516950003974 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 516950003975 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 516950003976 Coenzyme A binding pocket [chemical binding]; other site 516950003977 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 516950003978 active site 516950003979 ATP binding site [chemical binding]; other site 516950003980 Phosphotransferase enzyme family; Region: APH; pfam01636 516950003981 antibiotic binding site [chemical binding]; other site 516950003982 Omega Transcriptional Repressor; Region: Omega_Repress; pfam07764 516950003983 Ribosomal RNA adenine dimethylase; Region: RrnaAD; pfam00398 516950003984 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 516950003985 S-adenosylmethionine binding site [chemical binding]; other site 516950003986 multiple promoter invertase; Provisional; Region: mpi; PRK13413 516950003987 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 516950003988 catalytic residues [active] 516950003989 catalytic nucleophile [active] 516950003990 Presynaptic Site I dimer interface [polypeptide binding]; other site 516950003991 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 516950003992 Synaptic Flat tetramer interface [polypeptide binding]; other site 516950003993 Synaptic Site I dimer interface [polypeptide binding]; other site 516950003994 DNA binding site [nucleotide binding] 516950003995 Helix-turn-helix domain of resolvase; Region: HTH_7; pfam02796 516950003996 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 516950003997 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 516950003998 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 516950003999 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 516950004000 non-specific DNA binding site [nucleotide binding]; other site 516950004001 salt bridge; other site 516950004002 sequence-specific DNA binding site [nucleotide binding]; other site 516950004003 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 516950004004 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 516950004005 DNA binding residues [nucleotide binding] 516950004006 Helix-turn-helix domain; Region: HTH_16; pfam12645 516950004007 Excisionase from transposon Tn916; Region: Tn916-Xis; pfam09035 516950004008 DNA binding domain of tn916 integrase; Region: Integrase_DNA; pfam02920 516950004009 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 516950004010 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 516950004011 DNA binding site [nucleotide binding] 516950004012 active site 516950004013 Int/Topo IB signature motif; other site 516950004014 CAAX protease self-immunity; Region: Abi; pfam02517 516950004015 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 516950004016 cofactor binding site; other site 516950004017 DNA binding site [nucleotide binding] 516950004018 substrate interaction site [chemical binding]; other site 516950004019 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 516950004020 Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970 516950004021 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 516950004022 23S rRNA interface [nucleotide binding]; other site 516950004023 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 516950004024 chlorohydrolase; Validated; Region: PRK06687 516950004025 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 516950004026 active site 516950004027 putative substrate binding pocket [chemical binding]; other site 516950004028 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 516950004029 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 516950004030 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 516950004031 Walker A/P-loop; other site 516950004032 ATP binding site [chemical binding]; other site 516950004033 Q-loop/lid; other site 516950004034 ABC transporter signature motif; other site 516950004035 Walker B; other site 516950004036 D-loop; other site 516950004037 H-loop/switch region; other site 516950004038 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 516950004039 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 516950004040 APC10-like DOC1 domains in E3 ubiquitin ligases that mediate substrate ubiquitination; Region: APC10-like; cl02148 516950004041 putative ligand binding site [chemical binding]; other site 516950004042 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 516950004043 Walker A/P-loop; other site 516950004044 ATP binding site [chemical binding]; other site 516950004045 Q-loop/lid; other site 516950004046 ABC transporter signature motif; other site 516950004047 Walker B; other site 516950004048 D-loop; other site 516950004049 H-loop/switch region; other site 516950004050 Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225 516950004051 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 516950004052 SelR domain; Region: SelR; pfam01641 516950004053 homoserine kinase; Provisional; Region: PRK01212 516950004054 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 516950004055 homoserine dehydrogenase; Provisional; Region: PRK06349 516950004056 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 516950004057 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 516950004058 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 516950004059 adaptor protein; Provisional; Region: PRK02315 516950004060 O-antigen polysaccharide polymerase Wzy; Region: O-ag_pol_Wzy; pfam14296 516950004061 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 516950004062 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 516950004063 active site 516950004064 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 516950004065 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 516950004066 putative ADP-binding pocket [chemical binding]; other site 516950004067 LPS biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3475 516950004068 Transcriptional regulator [Transcription]; Region: LytR; COG1316 516950004069 prephenate dehydratase; Provisional; Region: PRK11898 516950004070 Prephenate dehydratase; Region: PDT; pfam00800 516950004071 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 516950004072 putative L-Phe binding site [chemical binding]; other site 516950004073 shikimate kinase; Reviewed; Region: aroK; PRK00131 516950004074 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 516950004075 ADP binding site [chemical binding]; other site 516950004076 magnesium binding site [ion binding]; other site 516950004077 putative shikimate binding site; other site 516950004078 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 516950004079 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 516950004080 hinge; other site 516950004081 active site 516950004082 hypothetical protein; Provisional; Region: PRK13676 516950004083 prephenate dehydrogenase; Validated; Region: PRK06545 516950004084 prephenate dehydrogenase; Validated; Region: PRK08507 516950004085 C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909 516950004086 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 516950004087 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 516950004088 Tetramer interface [polypeptide binding]; other site 516950004089 active site 516950004090 FMN-binding site [chemical binding]; other site 516950004091 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 516950004092 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 516950004093 active site 516950004094 dimer interface [polypeptide binding]; other site 516950004095 metal binding site [ion binding]; metal-binding site 516950004096 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 516950004097 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 516950004098 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 516950004099 shikimate binding site; other site 516950004100 NAD(P) binding site [chemical binding]; other site 516950004101 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 516950004102 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 516950004103 active site 516950004104 catalytic residue [active] 516950004105 dimer interface [polypeptide binding]; other site 516950004106 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 516950004107 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 516950004108 putative RNA binding site [nucleotide binding]; other site 516950004109 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 516950004110 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 516950004111 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 516950004112 Walker A/P-loop; other site 516950004113 ATP binding site [chemical binding]; other site 516950004114 Q-loop/lid; other site 516950004115 ABC transporter signature motif; other site 516950004116 Walker B; other site 516950004117 D-loop; other site 516950004118 H-loop/switch region; other site 516950004119 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 516950004120 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 516950004121 active site 516950004122 Na/Ca binding site [ion binding]; other site 516950004123 catalytic site [active] 516950004124 Domain of unknown function (DUF1939); Region: DUF1939; pfam09154 516950004125 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 516950004126 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 516950004127 motif 1; other site 516950004128 active site 516950004129 motif 2; other site 516950004130 motif 3; other site 516950004131 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 516950004132 DHHA1 domain; Region: DHHA1; pfam02272 516950004133 Uncharacterized conserved protein [Function unknown]; Region: COG4894 516950004134 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 516950004135 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 516950004136 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 516950004137 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 516950004138 dimer interface [polypeptide binding]; other site 516950004139 conserved gate region; other site 516950004140 putative PBP binding loops; other site 516950004141 ABC-ATPase subunit interface; other site 516950004142 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 516950004143 dimer interface [polypeptide binding]; other site 516950004144 conserved gate region; other site 516950004145 putative PBP binding loops; other site 516950004146 ABC-ATPase subunit interface; other site 516950004147 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 516950004148 ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300 516950004149 Walker A/P-loop; other site 516950004150 ATP binding site [chemical binding]; other site 516950004151 Q-loop/lid; other site 516950004152 ABC transporter signature motif; other site 516950004153 Walker B; other site 516950004154 D-loop; other site 516950004155 H-loop/switch region; other site 516950004156 TOBE domain; Region: TOBE_2; pfam08402 516950004157 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 516950004158 FAD binding domain; Region: FAD_binding_4; pfam01565 516950004159 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 516950004160 Putative membrane peptidase family (DUF2324); Region: DUF2324; cl01810 516950004161 Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527 516950004162 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 516950004163 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 516950004164 DNA-binding site [nucleotide binding]; DNA binding site 516950004165 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 516950004166 pyridoxal 5'-phosphate binding site [chemical binding]; other site 516950004167 homodimer interface [polypeptide binding]; other site 516950004168 catalytic residue [active] 516950004169 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 516950004170 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 516950004171 substrate binding pocket [chemical binding]; other site 516950004172 membrane-bound complex binding site; other site 516950004173 hinge residues; other site 516950004174 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 516950004175 PhoU domain; Region: PhoU; pfam01895 516950004176 PhoU domain; Region: PhoU; pfam01895 516950004177 phosphate transporter ATP-binding protein; Provisional; Region: PRK14239 516950004178 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 516950004179 Walker A/P-loop; other site 516950004180 ATP binding site [chemical binding]; other site 516950004181 Q-loop/lid; other site 516950004182 ABC transporter signature motif; other site 516950004183 Walker B; other site 516950004184 D-loop; other site 516950004185 H-loop/switch region; other site 516950004186 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 516950004187 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 516950004188 Walker A/P-loop; other site 516950004189 ATP binding site [chemical binding]; other site 516950004190 Q-loop/lid; other site 516950004191 ABC transporter signature motif; other site 516950004192 Walker B; other site 516950004193 D-loop; other site 516950004194 H-loop/switch region; other site 516950004195 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 516950004196 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 516950004197 dimer interface [polypeptide binding]; other site 516950004198 conserved gate region; other site 516950004199 putative PBP binding loops; other site 516950004200 ABC-ATPase subunit interface; other site 516950004201 sulfate transport protein; Provisional; Region: cysT; CHL00187 516950004202 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 516950004203 dimer interface [polypeptide binding]; other site 516950004204 conserved gate region; other site 516950004205 putative PBP binding loops; other site 516950004206 ABC-ATPase subunit interface; other site 516950004207 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 516950004208 phosphate binding protein; Region: ptsS_2; TIGR02136 516950004209 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 516950004210 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 516950004211 S-adenosylmethionine binding site [chemical binding]; other site 516950004212 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 516950004213 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 516950004214 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 516950004215 active site 516950004216 hypothetical protein; Provisional; Region: PRK04387 516950004217 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 516950004218 ArsC family; Region: ArsC; pfam03960 516950004219 putative catalytic residues [active] 516950004220 thiol/disulfide switch; other site 516950004221 Predicted membrane protein [Function unknown]; Region: COG4478 516950004222 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 516950004223 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 516950004224 active site 516950004225 motif I; other site 516950004226 motif II; other site 516950004227 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 516950004228 Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884 516950004229 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 516950004230 active site 516950004231 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 516950004232 active site 516950004233 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 516950004234 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 516950004235 FeS/SAM binding site; other site 516950004236 HemN C-terminal domain; Region: HemN_C; pfam06969 516950004237 YtxH-like protein; Region: YtxH; pfam12732 516950004238 Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768 516950004239 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 516950004240 HPr kinase/phosphorylase; Provisional; Region: PRK05428 516950004241 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 516950004242 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 516950004243 Hpr binding site; other site 516950004244 active site 516950004245 homohexamer subunit interaction site [polypeptide binding]; other site 516950004246 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 516950004247 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 516950004248 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 516950004249 active site 516950004250 trimer interface [polypeptide binding]; other site 516950004251 allosteric site; other site 516950004252 active site lid [active] 516950004253 hexamer (dimer of trimers) interface [polypeptide binding]; other site 516950004254 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 516950004255 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 516950004256 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 516950004257 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 516950004258 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 516950004259 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 516950004260 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 516950004261 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 516950004262 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 516950004263 homodimer interface [polypeptide binding]; other site 516950004264 NAD binding pocket [chemical binding]; other site 516950004265 ATP binding pocket [chemical binding]; other site 516950004266 Mg binding site [ion binding]; other site 516950004267 active-site loop [active] 516950004268 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 516950004269 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 516950004270 active site 516950004271 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 516950004272 Walker B; other site 516950004273 D-loop; other site 516950004274 H-loop/switch region; other site 516950004275 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 516950004276 Q-loop/lid; other site 516950004277 ABC transporter signature motif; other site 516950004278 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 516950004279 Peptidase family U32; Region: Peptidase_U32; pfam01136 516950004280 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 516950004281 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 516950004282 Peptidase family U32; Region: Peptidase_U32; pfam01136 516950004283 ApaLI-like restriction endonuclease; Region: RE_ApaLI; pfam09499 516950004284 ApaLI-like restriction endonuclease; Region: RE_ApaLI; pfam09499 516950004285 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 516950004286 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 516950004287 S-adenosylmethionine binding site [chemical binding]; other site 516950004288 Helix-turn-helix domain; Region: HTH_18; pfam12833 516950004289 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 516950004290 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 516950004291 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 516950004292 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 516950004293 Walker A/P-loop; other site 516950004294 ATP binding site [chemical binding]; other site 516950004295 Q-loop/lid; other site 516950004296 ABC transporter signature motif; other site 516950004297 Walker B; other site 516950004298 D-loop; other site 516950004299 H-loop/switch region; other site 516950004300 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 516950004301 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 516950004302 Walker A/P-loop; other site 516950004303 ATP binding site [chemical binding]; other site 516950004304 Q-loop/lid; other site 516950004305 ABC transporter signature motif; other site 516950004306 Walker B; other site 516950004307 D-loop; other site 516950004308 H-loop/switch region; other site 516950004309 Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605 516950004310 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 516950004311 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 516950004312 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 516950004313 Walker A/P-loop; other site 516950004314 ATP binding site [chemical binding]; other site 516950004315 Q-loop/lid; other site 516950004316 ABC transporter signature motif; other site 516950004317 Walker B; other site 516950004318 D-loop; other site 516950004319 H-loop/switch region; other site 516950004320 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 516950004321 cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166 516950004322 Walker A/P-loop; other site 516950004323 ATP binding site [chemical binding]; other site 516950004324 Q-loop/lid; other site 516950004325 ABC transporter signature motif; other site 516950004326 Walker B; other site 516950004327 D-loop; other site 516950004328 H-loop/switch region; other site 516950004329 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 516950004330 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 516950004331 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 516950004332 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 516950004333 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 516950004334 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 516950004335 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 516950004336 GMP synthase; Reviewed; Region: guaA; PRK00074 516950004337 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 516950004338 AMP/PPi binding site [chemical binding]; other site 516950004339 candidate oxyanion hole; other site 516950004340 catalytic triad [active] 516950004341 potential glutamine specificity residues [chemical binding]; other site 516950004342 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 516950004343 ATP Binding subdomain [chemical binding]; other site 516950004344 Dimerization subdomain; other site 516950004345 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 516950004346 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 516950004347 DNA-binding site [nucleotide binding]; DNA binding site 516950004348 UTRA domain; Region: UTRA; pfam07702 516950004349 EamA-like transporter family; Region: EamA; pfam00892 516950004350 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 516950004351 Beta-lactamase; Region: Beta-lactamase; pfam00144 516950004352 NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841 516950004353 active site 516950004354 catalytic triad [active] 516950004355 oxyanion hole [active] 516950004356 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 516950004357 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 516950004358 active site 516950004359 motif I; other site 516950004360 motif II; other site 516950004361 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 516950004362 CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381 516950004363 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 516950004364 putative active site [active] 516950004365 putative metal binding site [ion binding]; other site 516950004366 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 516950004367 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 516950004368 active site 516950004369 catalytic residues [active] 516950004370 metal binding site [ion binding]; metal-binding site 516950004371 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 516950004372 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 516950004373 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 516950004374 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 516950004375 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 516950004376 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 516950004377 Protein of unknown function (DUF4059); Region: DUF4059; pfam13268 516950004378 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 516950004379 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 516950004380 Walker A/P-loop; other site 516950004381 ATP binding site [chemical binding]; other site 516950004382 Q-loop/lid; other site 516950004383 ABC transporter signature motif; other site 516950004384 Walker B; other site 516950004385 D-loop; other site 516950004386 H-loop/switch region; other site 516950004387 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 516950004388 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 516950004389 ABC-ATPase subunit interface; other site 516950004390 putative PBP binding loops; other site 516950004391 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 516950004392 putative ArsC-like catalytic residues; other site 516950004393 putative TRX-like catalytic residues [active] 516950004394 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 516950004395 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 516950004396 DNA binding site [nucleotide binding] 516950004397 active site 516950004398 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 516950004399 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 516950004400 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 516950004401 Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272 516950004402 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 516950004403 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 516950004404 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 516950004405 Walker A/P-loop; other site 516950004406 ATP binding site [chemical binding]; other site 516950004407 Q-loop/lid; other site 516950004408 ABC transporter signature motif; other site 516950004409 Walker B; other site 516950004410 D-loop; other site 516950004411 H-loop/switch region; other site 516950004412 Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749 516950004413 predicted active site [active] 516950004414 catalytic triad [active] 516950004415 pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343 516950004416 PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP, present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727 516950004417 active site 516950004418 multimer interface [polypeptide binding]; other site 516950004419 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 516950004420 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 516950004421 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 516950004422 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 516950004423 ApbE family; Region: ApbE; pfam02424 516950004424 Predicted flavoprotein [General function prediction only]; Region: COG0431 516950004425 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 516950004426 Predicted flavoprotein [General function prediction only]; Region: COG0431 516950004427 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 516950004428 PAS domain; Region: PAS_10; pfam13596 516950004429 hypothetical protein; Provisional; Region: PRK02539 516950004430 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 516950004431 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471 516950004432 DALR anticodon binding domain; Region: DALR_1; pfam05746 516950004433 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 516950004434 dimer interface [polypeptide binding]; other site 516950004435 motif 1; other site 516950004436 active site 516950004437 motif 2; other site 516950004438 motif 3; other site 516950004439 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 516950004440 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 516950004441 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 516950004442 active site 516950004443 catalytic tetrad [active] 516950004444 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 516950004445 Catalytic NodB homology domain of Streptococcus pneumoniae peptidoglycan deacetylase PgdA, Bacillus subtilis BsYjeA protein, and their bacterial homologs; Region: CE4_SpPgdA_BsYjeA_like; cd10947 516950004446 NodB motif; other site 516950004447 active site 516950004448 catalytic site [active] 516950004449 Zn binding site [ion binding]; other site 516950004450 PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784 516950004451 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 516950004452 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 516950004453 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 516950004454 DEAD-like helicases superfamily; Region: DEXDc; smart00487 516950004455 ATP binding site [chemical binding]; other site 516950004456 putative Mg++ binding site [ion binding]; other site 516950004457 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 516950004458 nucleotide binding region [chemical binding]; other site 516950004459 ATP-binding site [chemical binding]; other site 516950004460 DDE superfamily endonuclease; Region: DDE_3; pfam13358 516950004461 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 516950004462 elongation factor Tu; Reviewed; Region: PRK00049 516950004463 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 516950004464 G1 box; other site 516950004465 GEF interaction site [polypeptide binding]; other site 516950004466 GTP/Mg2+ binding site [chemical binding]; other site 516950004467 Switch I region; other site 516950004468 G2 box; other site 516950004469 G3 box; other site 516950004470 Switch II region; other site 516950004471 G4 box; other site 516950004472 G5 box; other site 516950004473 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 516950004474 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 516950004475 Antibiotic Binding Site [chemical binding]; other site 516950004476 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 516950004477 amphipathic channel; other site 516950004478 Asn-Pro-Ala signature motifs; other site 516950004479 DDE superfamily endonuclease; Region: DDE_3; pfam13358 516950004480 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 516950004481 Transposase; Region: HTH_Tnp_IS630; pfam01710 516950004482 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 516950004483 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 516950004484 active site 516950004485 substrate binding site [chemical binding]; other site 516950004486 metal binding site [ion binding]; metal-binding site 516950004487 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 516950004488 Transposase; Region: DDE_Tnp_ISL3; pfam01610 516950004489 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 516950004490 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 516950004491 catalytic residues [active] 516950004492 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 516950004493 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 516950004494 substrate binding pocket [chemical binding]; other site 516950004495 membrane-bound complex binding site; other site 516950004496 hinge residues; other site 516950004497 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 516950004498 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 516950004499 Walker A/P-loop; other site 516950004500 ATP binding site [chemical binding]; other site 516950004501 Q-loop/lid; other site 516950004502 ABC transporter signature motif; other site 516950004503 Walker B; other site 516950004504 D-loop; other site 516950004505 H-loop/switch region; other site 516950004506 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 516950004507 dimer interface [polypeptide binding]; other site 516950004508 conserved gate region; other site 516950004509 putative PBP binding loops; other site 516950004510 ABC-ATPase subunit interface; other site 516950004511 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 516950004512 TPR motif; other site 516950004513 binding surface 516950004514 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 516950004515 binding surface 516950004516 TPR motif; other site 516950004517 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 516950004518 Domain of unknown function DUF20; Region: UPF0118; pfam01594 516950004519 3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706 516950004520 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 516950004521 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 516950004522 gamma subunit interface [polypeptide binding]; other site 516950004523 epsilon subunit interface [polypeptide binding]; other site 516950004524 LBP interface [polypeptide binding]; other site 516950004525 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 516950004526 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 516950004527 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 516950004528 alpha subunit interaction interface [polypeptide binding]; other site 516950004529 Walker A motif; other site 516950004530 ATP binding site [chemical binding]; other site 516950004531 Walker B motif; other site 516950004532 inhibitor binding site; inhibition site 516950004533 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 516950004534 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 516950004535 core domain interface [polypeptide binding]; other site 516950004536 delta subunit interface [polypeptide binding]; other site 516950004537 epsilon subunit interface [polypeptide binding]; other site 516950004538 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 516950004539 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 516950004540 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 516950004541 beta subunit interaction interface [polypeptide binding]; other site 516950004542 Walker A motif; other site 516950004543 ATP binding site [chemical binding]; other site 516950004544 Walker B motif; other site 516950004545 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 516950004546 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 516950004547 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 516950004548 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 516950004549 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 516950004550 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 516950004551 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 516950004552 F0F1 ATP synthase subunit C; Provisional; Region: PRK13467 516950004553 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 516950004554 Helix-turn-helix domain; Region: HTH_38; pfam13936 516950004555 Integrase core domain; Region: rve; pfam00665 516950004556 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 516950004557 Coenzyme A binding pocket [chemical binding]; other site 516950004558 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 516950004559 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 516950004560 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 516950004561 Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559 516950004562 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 516950004563 dimerization interface [polypeptide binding]; other site 516950004564 Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420 516950004565 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 516950004566 Coenzyme A binding pocket [chemical binding]; other site 516950004567 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 516950004568 Coenzyme A binding pocket [chemical binding]; other site 516950004569 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 516950004570 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 516950004571 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 516950004572 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 516950004573 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 516950004574 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 516950004575 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 516950004576 ATP binding site [chemical binding]; other site 516950004577 putative Mg++ binding site [ion binding]; other site 516950004578 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 516950004579 nucleotide binding region [chemical binding]; other site 516950004580 ATP-binding site [chemical binding]; other site 516950004581 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 516950004582 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 516950004583 pyridoxal 5'-phosphate binding site [chemical binding]; other site 516950004584 homodimer interface [polypeptide binding]; other site 516950004585 catalytic residue [active] 516950004586 cystathionine gamma-synthase; Reviewed; Region: PRK07269 516950004587 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 516950004588 homodimer interface [polypeptide binding]; other site 516950004589 substrate-cofactor binding pocket; other site 516950004590 pyridoxal 5'-phosphate binding site [chemical binding]; other site 516950004591 catalytic residue [active] 516950004592 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 516950004593 ABC transporter; Region: ABC_tran; pfam00005 516950004594 Q-loop/lid; other site 516950004595 ABC transporter signature motif; other site 516950004596 Walker B; other site 516950004597 D-loop; other site 516950004598 H-loop/switch region; other site 516950004599 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 516950004600 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 516950004601 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 516950004602 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 516950004603 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 516950004604 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 516950004605 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 516950004606 peptide binding site [polypeptide binding]; other site 516950004607 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 516950004608 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 516950004609 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022 516950004610 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 516950004611 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 516950004612 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 516950004613 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 516950004614 Domain of unknown function (DUF1803); Region: DUF1803; pfam08820 516950004615 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 516950004616 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 516950004617 DHH family; Region: DHH; pfam01368 516950004618 DHHA2 domain; Region: DHHA2; pfam02833 516950004619 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 516950004620 GIY-YIG motif/motif A; other site 516950004621 putative active site [active] 516950004622 putative metal binding site [ion binding]; other site 516950004623 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 516950004624 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 516950004625 S-adenosylmethionine binding site [chemical binding]; other site 516950004626 Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098 516950004627 hypothetical protein; Provisional; Region: PRK07252 516950004628 RNA binding site [nucleotide binding]; other site 516950004629 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 516950004630 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 516950004631 active site 516950004632 motif I; other site 516950004633 motif II; other site 516950004634 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 516950004635 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 516950004636 active site 516950004637 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 516950004638 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 516950004639 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 516950004640 dimer interface [polypeptide binding]; other site 516950004641 ssDNA binding site [nucleotide binding]; other site 516950004642 tetramer (dimer of dimers) interface [polypeptide binding]; other site 516950004643 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 516950004644 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 516950004645 AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs. This domain is a...; Region: AsnRS_cyto_like_N; cd04323 516950004646 putative dimer interface [polypeptide binding]; other site 516950004647 putative anticodon binding site; other site 516950004648 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 516950004649 homodimer interface [polypeptide binding]; other site 516950004650 motif 1; other site 516950004651 motif 2; other site 516950004652 active site 516950004653 motif 3; other site 516950004654 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262 516950004655 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 516950004656 aspartate aminotransferase; Provisional; Region: PRK05764 516950004657 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 516950004658 pyridoxal 5'-phosphate binding site [chemical binding]; other site 516950004659 homodimer interface [polypeptide binding]; other site 516950004660 catalytic residue [active] 516950004661 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 516950004662 Predicted flavoprotein [General function prediction only]; Region: COG0431 516950004663 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 516950004664 hypothetical protein; Validated; Region: PRK02101 516950004665 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 516950004666 active site 516950004667 catalytic residues [active] 516950004668 metal binding site [ion binding]; metal-binding site 516950004669 putative S-transferase; Provisional; Region: PRK11752 516950004670 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 516950004671 C-terminal domain interface [polypeptide binding]; other site 516950004672 GSH binding site (G-site) [chemical binding]; other site 516950004673 dimer interface [polypeptide binding]; other site 516950004674 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 516950004675 N-terminal domain interface [polypeptide binding]; other site 516950004676 dimer interface [polypeptide binding]; other site 516950004677 substrate binding pocket (H-site) [chemical binding]; other site 516950004678 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 516950004679 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 516950004680 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 516950004681 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 516950004682 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 516950004683 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 516950004684 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 516950004685 Cation efflux family; Region: Cation_efflux; pfam01545 516950004686 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994 516950004687 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 516950004688 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 516950004689 Walker A/P-loop; other site 516950004690 ATP binding site [chemical binding]; other site 516950004691 Q-loop/lid; other site 516950004692 ABC transporter signature motif; other site 516950004693 Walker B; other site 516950004694 D-loop; other site 516950004695 H-loop/switch region; other site 516950004696 ABC transporter; Region: ABC_tran_2; pfam12848 516950004697 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 516950004698 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 516950004699 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 516950004700 active site 516950004701 NTP binding site [chemical binding]; other site 516950004702 metal binding triad [ion binding]; metal-binding site 516950004703 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 516950004704 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 516950004705 dihydrodipicolinate reductase; Provisional; Region: PRK00048 516950004706 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 516950004707 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 516950004708 EDD domain protein, DegV family; Region: DegV; TIGR00762 516950004709 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 516950004710 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4835 516950004711 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 516950004712 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 516950004713 active site 516950004714 substrate binding site [chemical binding]; other site 516950004715 metal binding site [ion binding]; metal-binding site 516950004716 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856 516950004717 YbbR-like protein; Region: YbbR; pfam07949 516950004718 Uncharacterized conserved protein [Function unknown]; Region: COG1624 516950004719 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 516950004720 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 516950004721 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 516950004722 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 516950004723 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 516950004724 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 516950004725 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 516950004726 Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044 516950004727 dimer interface [polypeptide binding]; other site 516950004728 phosphate binding site [ion binding]; other site 516950004729 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 516950004730 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 516950004731 homotrimer interaction site [polypeptide binding]; other site 516950004732 putative active site [active] 516950004733 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 516950004734 G1 box; other site 516950004735 GTP/Mg2+ binding site [chemical binding]; other site 516950004736 Switch I region; other site 516950004737 G2 box; other site 516950004738 G3 box; other site 516950004739 Switch II region; other site 516950004740 G4 box; other site 516950004741 G5 box; other site 516950004742 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 516950004743 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 516950004744 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 516950004745 Walker A motif; other site 516950004746 ATP binding site [chemical binding]; other site 516950004747 Walker B motif; other site 516950004748 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 516950004749 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 516950004750 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 516950004751 folate binding site [chemical binding]; other site 516950004752 NADP+ binding site [chemical binding]; other site 516950004753 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 516950004754 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 516950004755 dimerization interface [polypeptide binding]; other site 516950004756 DPS ferroxidase diiron center [ion binding]; other site 516950004757 ion pore; other site 516950004758 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 516950004759 The LytC lysozyme of Streptococcus pneumoniae is a bacterial cell wall hydrolase that cleaves the beta1-4-glycosydic bond located between the N-acetylmuramoyl-N-glucosaminyl residues of the cell wall polysaccharide chains. LytC is composed of a...; Region: GH25_LytC-like; cd06414 516950004760 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 516950004761 active site 516950004762 triosephosphate isomerase; Provisional; Region: PRK14567 516950004763 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 516950004764 substrate binding site [chemical binding]; other site 516950004765 dimer interface [polypeptide binding]; other site 516950004766 catalytic triad [active] 516950004767 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 516950004768 DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446 516950004769 Homoserine trans-succinylase [Amino acid transport and metabolism]; Region: MetA; COG1897 516950004770 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 516950004771 proposed active site lysine [active] 516950004772 conserved cys residue [active] 516950004773 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 516950004774 active site 516950004775 Methyltransferase domain; Region: Methyltransf_31; pfam13847 516950004776 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 516950004777 S-adenosylmethionine binding site [chemical binding]; other site 516950004778 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 516950004779 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 516950004780 Walker A/P-loop; other site 516950004781 ATP binding site [chemical binding]; other site 516950004782 Q-loop/lid; other site 516950004783 ABC transporter signature motif; other site 516950004784 Walker B; other site 516950004785 D-loop; other site 516950004786 H-loop/switch region; other site 516950004787 TOBE domain; Region: TOBE_2; pfam08402 516950004788 Isochorismatase family; Region: Isochorismatase; pfam00857 516950004789 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 516950004790 catalytic triad [active] 516950004791 conserved cis-peptide bond; other site 516950004792 Pleiotropic transcriptional repressor [Transcription]; Region: CodY; COG4465 516950004793 CodY GAF-like domain; Region: CodY; pfam06018 516950004794 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 516950004795 putative DNA binding site [nucleotide binding]; other site 516950004796 putative Zn2+ binding site [ion binding]; other site 516950004797 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 516950004798 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 516950004799 ATP binding site [chemical binding]; other site 516950004800 Mg++ binding site [ion binding]; other site 516950004801 motif III; other site 516950004802 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 516950004803 nucleotide binding region [chemical binding]; other site 516950004804 ATP-binding site [chemical binding]; other site 516950004805 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 516950004806 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 516950004807 putative substrate translocation pore; other site 516950004808 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 516950004809 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 516950004810 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 516950004811 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 516950004812 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 516950004813 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 516950004814 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 516950004815 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 516950004816 catalytic triad [active] 516950004817 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 516950004818 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 516950004819 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 516950004820 active site 516950004821 putative transposase OrfB; Reviewed; Region: PHA02517 516950004822 HTH-like domain; Region: HTH_21; pfam13276 516950004823 Integrase core domain; Region: rve; pfam00665 516950004824 Integrase core domain; Region: rve_2; pfam13333 516950004825 Predicted membrane protein [Function unknown]; Region: COG4720 516950004826 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 516950004827 dimer interface [polypeptide binding]; other site 516950004828 substrate binding site [chemical binding]; other site 516950004829 ATP binding site [chemical binding]; other site 516950004830 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 516950004831 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 516950004832 dimerization interface 3.5A [polypeptide binding]; other site 516950004833 active site 516950004834 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 516950004835 Major Facilitator Superfamily; Region: MFS_1; pfam07690 516950004836 putative substrate translocation pore; other site 516950004837 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 516950004838 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 516950004839 PhnA protein; Region: PhnA; pfam03831 516950004840 cytidylate kinase; Provisional; Region: cmk; PRK00023 516950004841 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 516950004842 CMP-binding site; other site 516950004843 The sites determining sugar specificity; other site 516950004844 Ferredoxin [Energy production and conversion]; Region: Fer; COG1141 516950004845 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 516950004846 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 516950004847 Ligand binding site; other site 516950004848 Putative Catalytic site; other site 516950004849 DXD motif; other site 516950004850 UDP-glucose 4-epimerase; Region: PLN02240 516950004851 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 516950004852 NAD binding site [chemical binding]; other site 516950004853 homodimer interface [polypeptide binding]; other site 516950004854 active site 516950004855 substrate binding site [chemical binding]; other site 516950004856 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 516950004857 Uncharacterized conserved protein [Function unknown]; Region: COG0327 516950004858 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 516950004859 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 516950004860 Family of unknown function (DUF633); Region: DUF633; pfam04816 516950004861 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 516950004862 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 516950004863 Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147 516950004864 LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cd04434 516950004865 active site 516950004866 zinc binding site [ion binding]; other site 516950004867 Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455 516950004868 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 516950004869 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 516950004870 ATP binding site [chemical binding]; other site 516950004871 putative Mg++ binding site [ion binding]; other site 516950004872 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 516950004873 nucleotide binding region [chemical binding]; other site 516950004874 ATP-binding site [chemical binding]; other site 516950004875 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 516950004876 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 516950004877 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 516950004878 motif II; other site 516950004879 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 516950004880 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 516950004881 putative acyl-acceptor binding pocket; other site 516950004882 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 516950004883 Cadmium resistance transporter; Region: Cad; pfam03596 516950004884 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 516950004885 16S/18S rRNA binding site [nucleotide binding]; other site 516950004886 S13e-L30e interaction site [polypeptide binding]; other site 516950004887 25S rRNA binding site [nucleotide binding]; other site 516950004888 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 516950004889 NADH(P)-binding; Region: NAD_binding_10; pfam13460 516950004890 NAD binding site [chemical binding]; other site 516950004891 substrate binding site [chemical binding]; other site 516950004892 putative active site [active] 516950004893 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 516950004894 metal binding site [ion binding]; metal-binding site 516950004895 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 516950004896 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 516950004897 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 516950004898 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 516950004899 active site 516950004900 dimer interface [polypeptide binding]; other site 516950004901 motif 1; other site 516950004902 motif 2; other site 516950004903 motif 3; other site 516950004904 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 516950004905 anticodon binding site; other site 516950004906 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 516950004907 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 516950004908 ATP binding site [chemical binding]; other site 516950004909 Mg2+ binding site [ion binding]; other site 516950004910 G-X-G motif; other site 516950004911 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 516950004912 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 516950004913 active site 516950004914 phosphorylation site [posttranslational modification] 516950004915 intermolecular recognition site; other site 516950004916 dimerization interface [polypeptide binding]; other site 516950004917 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 516950004918 DNA binding site [nucleotide binding] 516950004919 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 516950004920 nucleophilic elbow; other site 516950004921 catalytic triad; other site 516950004922 Predicted transcriptional regulator [Transcription]; Region: COG1959 516950004923 Transcriptional regulator; Region: Rrf2; pfam02082 516950004924 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 516950004925 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 516950004926 active site 516950004927 metal binding site [ion binding]; metal-binding site 516950004928 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 516950004929 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 516950004930 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 516950004931 FeoA domain; Region: FeoA; pfam04023 516950004932 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 516950004933 Transposase; Region: DDE_Tnp_ISL3; pfam01610 516950004934 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 516950004935 putative active site [active] 516950004936 dimerization interface [polypeptide binding]; other site 516950004937 putative tRNAtyr binding site [nucleotide binding]; other site 516950004938 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 516950004939 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 516950004940 Zn2+ binding site [ion binding]; other site 516950004941 Mg2+ binding site [ion binding]; other site 516950004942 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 516950004943 synthetase active site [active] 516950004944 NTP binding site [chemical binding]; other site 516950004945 metal binding site [ion binding]; metal-binding site 516950004946 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 516950004947 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 516950004948 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 516950004949 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 516950004950 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 516950004951 active site 516950004952 Zn binding site [ion binding]; other site 516950004953 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 516950004954 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 516950004955 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 516950004956 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 516950004957 ABC-ATPase subunit interface; other site 516950004958 dimer interface [polypeptide binding]; other site 516950004959 putative PBP binding regions; other site 516950004960 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 516950004961 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 516950004962 metal binding site [ion binding]; metal-binding site 516950004963 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 516950004964 dimer interface [polypeptide binding]; other site 516950004965 catalytic triad [active] 516950004966 peroxidatic and resolving cysteines [active] 516950004967 FtsX-like permease family; Region: FtsX; pfam02687 516950004968 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 516950004969 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 516950004970 FtsX-like permease family; Region: FtsX; pfam02687 516950004971 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 516950004972 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 516950004973 Walker A/P-loop; other site 516950004974 ATP binding site [chemical binding]; other site 516950004975 Q-loop/lid; other site 516950004976 ABC transporter signature motif; other site 516950004977 Walker B; other site 516950004978 D-loop; other site 516950004979 H-loop/switch region; other site 516950004980 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 516950004981 catalytic core [active] 516950004982 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 516950004983 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 516950004984 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 516950004985 active site 516950004986 HIGH motif; other site 516950004987 nucleotide binding site [chemical binding]; other site 516950004988 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 516950004989 active site 516950004990 KMSKS motif; other site 516950004991 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 516950004992 tRNA binding surface [nucleotide binding]; other site 516950004993 anticodon binding site; other site 516950004994 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 516950004995 DivIVA domain; Region: DivI1A_domain; TIGR03544 516950004996 Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599 516950004997 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 516950004998 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 516950004999 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 516950005000 RNA binding surface [nucleotide binding]; other site 516950005001 YGGT family; Region: YGGT; pfam02325 516950005002 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799 516950005003 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 516950005004 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 516950005005 catalytic residue [active] 516950005006 cell division protein FtsZ; Validated; Region: PRK09330 516950005007 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 516950005008 nucleotide binding site [chemical binding]; other site 516950005009 SulA interaction site; other site 516950005010 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 516950005011 Cell division protein FtsA; Region: FtsA; smart00842 516950005012 Cell division protein FtsA; Region: FtsA; pfam14450 516950005013 Domain of unknown function (DUF3484); Region: DUF3484; pfam11983 516950005014 Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529 516950005015 Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535 516950005016 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672 516950005017 nudix motif; other site 516950005018 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 516950005019 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 516950005020 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 516950005021 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 516950005022 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 516950005023 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 516950005024 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 516950005025 recombination protein RecR; Reviewed; Region: recR; PRK00076 516950005026 RecR protein; Region: RecR; pfam02132 516950005027 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 516950005028 putative active site [active] 516950005029 putative metal-binding site [ion binding]; other site 516950005030 tetramer interface [polypeptide binding]; other site 516950005031 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 516950005032 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 516950005033 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 516950005034 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 516950005035 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 516950005036 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 516950005037 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 516950005038 putative active site [active] 516950005039 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 516950005040 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 516950005041 nucleotide binding site [chemical binding]; other site 516950005042 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 516950005043 Class I aldolases; Region: Aldolase_Class_I; cl17187 516950005044 catalytic residue [active] 516950005045 Protein of unknown function, DUF624; Region: DUF624; pfam04854 516950005046 Domain of unknown function (DUF386); Region: DUF386; pfam04074 516950005047 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 516950005048 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 516950005049 dimer interface [polypeptide binding]; other site 516950005050 conserved gate region; other site 516950005051 putative PBP binding loops; other site 516950005052 ABC-ATPase subunit interface; other site 516950005053 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 516950005054 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 516950005055 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 516950005056 putative PBP binding loops; other site 516950005057 dimer interface [polypeptide binding]; other site 516950005058 ABC-ATPase subunit interface; other site 516950005059 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 516950005060 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 516950005061 PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002 516950005062 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 516950005063 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 516950005064 active site turn [active] 516950005065 phosphorylation site [posttranslational modification] 516950005066 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 516950005067 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 516950005068 putative active site cavity [active] 516950005069 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 516950005070 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 516950005071 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 516950005072 Neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: NanH; COG4409 516950005073 Sialidase, N-terminal domain; Region: Sialidase; pfam02973 516950005074 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 516950005075 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 516950005076 Asp-box motif; other site 516950005077 catalytic site [active] 516950005078 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 516950005079 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 516950005080 dimer interface [polypeptide binding]; other site 516950005081 conserved gate region; other site 516950005082 putative PBP binding loops; other site 516950005083 ABC-ATPase subunit interface; other site 516950005084 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 516950005085 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 516950005086 dimer interface [polypeptide binding]; other site 516950005087 conserved gate region; other site 516950005088 putative PBP binding loops; other site 516950005089 ABC-ATPase subunit interface; other site 516950005090 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 516950005091 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 516950005092 uncharacterized protein, YhcH/YjgK/YiaL family; Region: TIGR00022 516950005093 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 516950005094 Sialidase, N-terminal domain; Region: Sialidase; pfam02973 516950005095 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 516950005096 catalytic site [active] 516950005097 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 516950005098 Asp-box motif; other site 516950005099 Asp-box motif; other site 516950005100 catalytic site [active] 516950005101 Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448 516950005102 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 516950005103 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 516950005104 ssDNA binding site; other site 516950005105 generic binding surface II; other site 516950005106 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 516950005107 ATP binding site [chemical binding]; other site 516950005108 putative Mg++ binding site [ion binding]; other site 516950005109 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 516950005110 nucleotide binding region [chemical binding]; other site 516950005111 ATP-binding site [chemical binding]; other site 516950005112 alanine racemase; Reviewed; Region: alr; PRK00053 516950005113 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 516950005114 active site 516950005115 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 516950005116 dimer interface [polypeptide binding]; other site 516950005117 substrate binding site [chemical binding]; other site 516950005118 catalytic residues [active] 516950005119 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 516950005120 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG0722 516950005121 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 516950005122 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG0722 516950005123 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 516950005124 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 516950005125 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 516950005126 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 516950005127 nucleotide binding region [chemical binding]; other site 516950005128 ATP-binding site [chemical binding]; other site 516950005129 SEC-C motif; Region: SEC-C; pfam02810 516950005130 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 516950005131 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 516950005132 Walker A/P-loop; other site 516950005133 ATP binding site [chemical binding]; other site 516950005134 Q-loop/lid; other site 516950005135 ABC transporter signature motif; other site 516950005136 Walker B; other site 516950005137 D-loop; other site 516950005138 H-loop/switch region; other site 516950005139 GTP-binding protein Der; Reviewed; Region: PRK00093 516950005140 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 516950005141 G1 box; other site 516950005142 GTP/Mg2+ binding site [chemical binding]; other site 516950005143 Switch I region; other site 516950005144 G2 box; other site 516950005145 Switch II region; other site 516950005146 G3 box; other site 516950005147 G4 box; other site 516950005148 G5 box; other site 516950005149 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 516950005150 G1 box; other site 516950005151 GTP/Mg2+ binding site [chemical binding]; other site 516950005152 Switch I region; other site 516950005153 G2 box; other site 516950005154 G3 box; other site 516950005155 Switch II region; other site 516950005156 G4 box; other site 516950005157 G5 box; other site 516950005158 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 516950005159 dimer interface [polypeptide binding]; other site 516950005160 FMN binding site [chemical binding]; other site 516950005161 NADPH bind site [chemical binding]; other site 516950005162 primosomal protein DnaI; Reviewed; Region: PRK08939 516950005163 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 516950005164 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 516950005165 Walker A motif; other site 516950005166 ATP binding site [chemical binding]; other site 516950005167 Walker B motif; other site 516950005168 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 516950005169 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 516950005170 ATP cone domain; Region: ATP-cone; pfam03477 516950005171 Predicted transcriptional regulators [Transcription]; Region: COG1725 516950005172 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 516950005173 DNA-binding site [nucleotide binding]; DNA binding site 516950005174 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 516950005175 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 516950005176 Walker A/P-loop; other site 516950005177 ATP binding site [chemical binding]; other site 516950005178 Q-loop/lid; other site 516950005179 ABC transporter signature motif; other site 516950005180 Walker B; other site 516950005181 D-loop; other site 516950005182 H-loop/switch region; other site 516950005183 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 516950005184 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152 516950005185 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 516950005186 Walker A/P-loop; other site 516950005187 ATP binding site [chemical binding]; other site 516950005188 Q-loop/lid; other site 516950005189 ABC transporter signature motif; other site 516950005190 Walker B; other site 516950005191 D-loop; other site 516950005192 H-loop/switch region; other site 516950005193 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 516950005194 Uncharacterized conserved protein [Function unknown]; Region: COG0398 516950005195 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 516950005196 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 516950005197 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 516950005198 nucleotide binding site [chemical binding]; other site 516950005199 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 516950005200 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 516950005201 active site turn [active] 516950005202 phosphorylation site [posttranslational modification] 516950005203 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 516950005204 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 516950005205 HPr interaction site; other site 516950005206 glycerol kinase (GK) interaction site [polypeptide binding]; other site 516950005207 active site 516950005208 phosphorylation site [posttranslational modification] 516950005209 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 516950005210 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 516950005211 substrate binding [chemical binding]; other site 516950005212 active site 516950005213 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 516950005214 Transcriptional regulators [Transcription]; Region: PurR; COG1609 516950005215 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 516950005216 DNA binding site [nucleotide binding] 516950005217 domain linker motif; other site 516950005218 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 516950005219 dimerization interface [polypeptide binding]; other site 516950005220 ligand binding site [chemical binding]; other site 516950005221 sodium binding site [ion binding]; other site 516950005222 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 516950005223 homodimer interface [polypeptide binding]; other site 516950005224 catalytic residues [active] 516950005225 NAD binding site [chemical binding]; other site 516950005226 substrate binding pocket [chemical binding]; other site 516950005227 flexible flap; other site 516950005228 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 516950005229 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 516950005230 dimer interface [polypeptide binding]; other site 516950005231 active site 516950005232 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 516950005233 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 516950005234 Uncharacterized conserved protein [Function unknown]; Region: COG3610 516950005235 Uncharacterized conserved protein [Function unknown]; Region: COG2966 516950005236 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 516950005237 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 516950005238 Catalytic domain of Protein Kinases; Region: PKc; cd00180 516950005239 active site 516950005240 ATP binding site [chemical binding]; other site 516950005241 substrate binding site [chemical binding]; other site 516950005242 activation loop (A-loop); other site 516950005243 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815 516950005244 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 516950005245 PASTA domain; Region: PASTA; smart00740 516950005246 PASTA domain; Region: PASTA; smart00740 516950005247 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 516950005248 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 516950005249 active site 516950005250 16S rRNA methyltransferase B; Provisional; Region: PRK14902 516950005251 NusB family; Region: NusB; pfam01029 516950005252 putative RNA binding site [nucleotide binding]; other site 516950005253 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 516950005254 S-adenosylmethionine binding site [chemical binding]; other site 516950005255 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 516950005256 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 516950005257 putative active site [active] 516950005258 substrate binding site [chemical binding]; other site 516950005259 putative cosubstrate binding site; other site 516950005260 catalytic site [active] 516950005261 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 516950005262 substrate binding site [chemical binding]; other site 516950005263 primosome assembly protein PriA; Validated; Region: PRK05580 516950005264 helicase superfamily c-terminal domain; Region: HELICc; smart00490 516950005265 ATP-binding site [chemical binding]; other site 516950005266 DEAD-like helicases superfamily; Region: DEXDc; smart00487 516950005267 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 516950005268 ATP binding site [chemical binding]; other site 516950005269 putative Mg++ binding site [ion binding]; other site 516950005270 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 516950005271 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 516950005272 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 516950005273 catalytic site [active] 516950005274 G-X2-G-X-G-K; other site 516950005275 hypothetical protein; Provisional; Region: PRK00106 516950005276 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 516950005277 Zn2+ binding site [ion binding]; other site 516950005278 Mg2+ binding site [ion binding]; other site 516950005279 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 516950005280 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 516950005281 hypothetical protein; Provisional; Region: PRK13670 516950005282 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636 516950005283 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 516950005284 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 516950005285 S-adenosylmethionine binding site [chemical binding]; other site 516950005286 Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799 516950005287 Isochorismatase family; Region: Isochorismatase; pfam00857 516950005288 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 516950005289 catalytic triad [active] 516950005290 conserved cis-peptide bond; other site 516950005291 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 516950005292 Zn2+ binding site [ion binding]; other site 516950005293 Mg2+ binding site [ion binding]; other site 516950005294 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 516950005295 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 516950005296 active site 516950005297 (T/H)XGH motif; other site 516950005298 Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534 516950005299 GTPase YqeH; Provisional; Region: PRK13796 516950005300 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 516950005301 GTP/Mg2+ binding site [chemical binding]; other site 516950005302 G4 box; other site 516950005303 G5 box; other site 516950005304 G1 box; other site 516950005305 Switch I region; other site 516950005306 G2 box; other site 516950005307 G3 box; other site 516950005308 Switch II region; other site 516950005309 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 516950005310 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 516950005311 active site 516950005312 motif I; other site 516950005313 motif II; other site 516950005314 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 516950005315 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 516950005316 Cl binding site [ion binding]; other site 516950005317 oligomer interface [polypeptide binding]; other site 516950005318 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 516950005319 Mechanosensitive ion channel; Region: MS_channel; pfam00924 516950005320 serine/threonine transporter SstT; Provisional; Region: PRK14695 516950005321 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 516950005322 Predicted membrane protein [Function unknown]; Region: COG4129 516950005323 Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081 516950005324 DUF939 C-terminal domain; Region: DUF939_C; pfam11728 516950005325 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 516950005326 Transposase; Region: DDE_Tnp_ISL3; pfam01610 516950005327 accessory Sec system glycosyltransferase GtfB; Region: TIGR02919 516950005328 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 516950005329 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 516950005330 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 516950005331 preprotein translocase subunit SecA; Reviewed; Region: PRK09200 516950005332 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 516950005333 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 516950005334 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 516950005335 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 516950005336 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 516950005337 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768 516950005338 Adenylate cyclase associated (CAP) N terminal; Region: CAP_N; pfam01213 516950005339 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417 516950005340 SecY translocase; Region: SecY; pfam00344 516950005341 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 516950005342 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 516950005343 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 516950005344 Ligand binding site; other site 516950005345 metal-binding site 516950005346 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 516950005347 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 516950005348 Ligand binding site; other site 516950005349 metal-binding site 516950005350 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 516950005351 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 516950005352 Ligand binding site; other site 516950005353 metal-binding site 516950005354 glycosyltransferase, SP_1767 family; Region: glyco_access_1; TIGR03728 516950005355 beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814 516950005356 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 516950005357 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 516950005358 Ligand binding site; other site 516950005359 metal-binding site 516950005360 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 516950005361 active site 516950005362 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 516950005363 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 516950005364 Ligand binding site; other site 516950005365 metal-binding site 516950005366 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 516950005367 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 516950005368 trimer interface [polypeptide binding]; other site 516950005369 active site 516950005370 substrate binding site [chemical binding]; other site 516950005371 CoA binding site [chemical binding]; other site 516950005372 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 516950005373 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 516950005374 active site 516950005375 Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442 516950005376 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 516950005377 Ligand binding site; other site 516950005378 metal-binding site 516950005379 serine-rich repeat adhesion glycoprotein AST domain; Region: ser_adhes_Nterm; TIGR04224 516950005380 Gram positive anchor; Region: Gram_pos_anchor; pfam00746 516950005381 DDE superfamily endonuclease; Region: DDE_3; pfam13358 516950005382 MarR family; Region: MarR_2; pfam12802 516950005383 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 516950005384 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 516950005385 catalytic residues [active] 516950005386 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 516950005387 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 516950005388 amphipathic channel; other site 516950005389 Asn-Pro-Ala signature motifs; other site 516950005390 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 516950005391 oligoendopeptidase F; Region: pepF; TIGR00181 516950005392 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 516950005393 Zn binding site [ion binding]; other site 516950005394 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 516950005395 RNA methyltransferase, RsmE family; Region: TIGR00046 516950005396 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 516950005397 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 516950005398 S-adenosylmethionine binding site [chemical binding]; other site 516950005399 Bacteriophage abortive infection AbiH; Region: AbiH; pfam14253 516950005400 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 516950005401 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 516950005402 active site 516950005403 catalytic triad [active] 516950005404 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 516950005405 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 516950005406 Walker A motif; other site 516950005407 ATP binding site [chemical binding]; other site 516950005408 Walker B motif; other site 516950005409 arginine finger; other site 516950005410 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 516950005411 Peptidase family M50; Region: Peptidase_M50; pfam02163 516950005412 Protein of unknown function (DUF3013); Region: DUF3013; pfam11217 516950005413 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 516950005414 recombination factor protein RarA; Reviewed; Region: PRK13342 516950005415 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 516950005416 Walker A motif; other site 516950005417 ATP binding site [chemical binding]; other site 516950005418 Walker B motif; other site 516950005419 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 516950005420 arginine finger; other site 516950005421 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 516950005422 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 516950005423 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 516950005424 substrate binding [chemical binding]; other site 516950005425 active site 516950005426 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 516950005427 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 516950005428 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 516950005429 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 516950005430 dimer interface [polypeptide binding]; other site 516950005431 conserved gate region; other site 516950005432 ABC-ATPase subunit interface; other site 516950005433 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 516950005434 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 516950005435 dimer interface [polypeptide binding]; other site 516950005436 conserved gate region; other site 516950005437 ABC-ATPase subunit interface; other site 516950005438 Transcriptional regulators [Transcription]; Region: PurR; COG1609 516950005439 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 516950005440 DNA binding site [nucleotide binding] 516950005441 domain linker motif; other site 516950005442 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 516950005443 dimerization interface [polypeptide binding]; other site 516950005444 ligand binding site [chemical binding]; other site 516950005445 sodium binding site [ion binding]; other site 516950005446 M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280 516950005447 Mga helix-turn-helix domain; Region: Mga; pfam05043 516950005448 M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270 516950005449 Predicted membrane protein [Function unknown]; Region: COG2261 516950005450 Small integral membrane protein [Function unknown]; Region: COG5547 516950005451 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 516950005452 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 516950005453 Uncharacterized conserved protein [Function unknown]; Region: COG1262 516950005454 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 516950005455 arylsulfatase; Provisional; Region: PRK13759 516950005456 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 516950005457 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 516950005458 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 516950005459 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 516950005460 active site 516950005461 methionine cluster; other site 516950005462 phosphorylation site [posttranslational modification] 516950005463 metal binding site [ion binding]; metal-binding site 516950005464 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 516950005465 active site 516950005466 P-loop; other site 516950005467 phosphorylation site [posttranslational modification] 516950005468 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cl04270 516950005469 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 516950005470 MarR family; Region: MarR_2; pfam12802 516950005471 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 516950005472 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 516950005473 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 516950005474 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 516950005475 Coenzyme A binding pocket [chemical binding]; other site 516950005476 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 516950005477 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 516950005478 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 516950005479 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 516950005480 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 516950005481 substrate binding site [chemical binding]; other site 516950005482 active site 516950005483 catalytic residues [active] 516950005484 heterodimer interface [polypeptide binding]; other site 516950005485 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 516950005486 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 516950005487 pyridoxal 5'-phosphate binding site [chemical binding]; other site 516950005488 catalytic residue [active] 516950005489 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 516950005490 active site 516950005491 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 516950005492 active site 516950005493 ribulose/triose binding site [chemical binding]; other site 516950005494 phosphate binding site [ion binding]; other site 516950005495 substrate (anthranilate) binding pocket [chemical binding]; other site 516950005496 product (indole) binding pocket [chemical binding]; other site 516950005497 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 516950005498 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 516950005499 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 516950005500 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 516950005501 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 516950005502 glutamine binding [chemical binding]; other site 516950005503 catalytic triad [active] 516950005504 anthranilate synthase component I; Provisional; Region: PRK13570 516950005505 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 516950005506 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 516950005507 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 516950005508 Transcriptional regulators [Transcription]; Region: PurR; COG1609 516950005509 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 516950005510 DNA binding site [nucleotide binding] 516950005511 domain linker motif; other site 516950005512 Ligand-binding domain of a transcription repressor, FucR, which functions as a molecular sensor of L-fucose availability; Region: PBP1_FucR_like; cd06276 516950005513 putative dimerization interface [polypeptide binding]; other site 516950005514 putative ligand binding site [chemical binding]; other site 516950005515 Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285 516950005516 MgtC family; Region: MgtC; pfam02308 516950005517 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 516950005518 dimer interface [polypeptide binding]; other site 516950005519 conserved gate region; other site 516950005520 putative PBP binding loops; other site 516950005521 ABC-ATPase subunit interface; other site 516950005522 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 516950005523 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 516950005524 putative PBP binding loops; other site 516950005525 dimer interface [polypeptide binding]; other site 516950005526 ABC-ATPase subunit interface; other site 516950005527 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 516950005528 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 516950005529 Walker A/P-loop; other site 516950005530 ATP binding site [chemical binding]; other site 516950005531 Q-loop/lid; other site 516950005532 ABC transporter signature motif; other site 516950005533 Walker B; other site 516950005534 D-loop; other site 516950005535 H-loop/switch region; other site 516950005536 TOBE domain; Region: TOBE; pfam03459 516950005537 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 516950005538 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 516950005539 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5255 516950005540 Domain of unknown function (DUF1868); Region: 2H-phosphodiest; pfam08975 516950005541 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 516950005542 Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434 516950005543 Pectate lyase; Region: Pec_lyase_C; cl01593 516950005544 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 516950005545 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 516950005546 inhibitor-cofactor binding pocket; inhibition site 516950005547 pyridoxal 5'-phosphate binding site [chemical binding]; other site 516950005548 catalytic residue [active] 516950005549 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 516950005550 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 516950005551 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 516950005552 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 516950005553 Walker A/P-loop; other site 516950005554 ATP binding site [chemical binding]; other site 516950005555 Q-loop/lid; other site 516950005556 ABC transporter signature motif; other site 516950005557 Walker B; other site 516950005558 D-loop; other site 516950005559 H-loop/switch region; other site 516950005560 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 516950005561 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 516950005562 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 516950005563 Walker A/P-loop; other site 516950005564 ATP binding site [chemical binding]; other site 516950005565 Q-loop/lid; other site 516950005566 ABC transporter signature motif; other site 516950005567 Walker B; other site 516950005568 D-loop; other site 516950005569 H-loop/switch region; other site 516950005570 Predicted membrane protein [Function unknown]; Region: COG2323 516950005571 Protein of unknown function (DUF3290); Region: DUF3290; pfam11694 516950005572 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 516950005573 active site 516950005574 putative catalytic site [active] 516950005575 DNA binding site [nucleotide binding] 516950005576 putative phosphate binding site [ion binding]; other site 516950005577 metal binding site A [ion binding]; metal-binding site 516950005578 AP binding site [nucleotide binding]; other site 516950005579 metal binding site B [ion binding]; metal-binding site 516950005580 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 516950005581 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 516950005582 active site 516950005583 xanthine permease; Region: pbuX; TIGR03173 516950005584 Sulfate transporter family; Region: Sulfate_transp; pfam00916 516950005585 DpnD/PcfM-like protein; Region: DpnD-PcfM; pfam14207 516950005586 Dam-replacing family; Region: DRP; pfam06044 516950005587 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 516950005588 CoenzymeA binding site [chemical binding]; other site 516950005589 subunit interaction site [polypeptide binding]; other site 516950005590 PHB binding site; other site 516950005591 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 516950005592 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 516950005593 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 516950005594 galactokinase; Provisional; Region: PRK05322 516950005595 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 516950005596 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 516950005597 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 516950005598 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 516950005599 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 516950005600 DNA binding site [nucleotide binding] 516950005601 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 516950005602 putative dimerization interface [polypeptide binding]; other site 516950005603 putative ligand binding site [chemical binding]; other site 516950005604 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 516950005605 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 516950005606 catalytic Zn binding site [ion binding]; other site 516950005607 NAD(P) binding site [chemical binding]; other site 516950005608 structural Zn binding site [ion binding]; other site 516950005609 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 516950005610 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 516950005611 DNA binding residues [nucleotide binding] 516950005612 putative dimer interface [polypeptide binding]; other site 516950005613 Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230 516950005614 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 516950005615 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 516950005616 Utp21 specific WD40 associated putative domain; Region: Utp21; pfam04192 516950005617 nicotinamide mononucleotide transporter PnuC; Region: NMN_trans_PnuC; TIGR01528 516950005618 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 516950005619 dimer interface [polypeptide binding]; other site 516950005620 conserved gate region; other site 516950005621 ABC-ATPase subunit interface; other site 516950005622 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 516950005623 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 516950005624 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 516950005625 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 516950005626 Walker A/P-loop; other site 516950005627 ATP binding site [chemical binding]; other site 516950005628 Q-loop/lid; other site 516950005629 ABC transporter signature motif; other site 516950005630 Walker B; other site 516950005631 D-loop; other site 516950005632 H-loop/switch region; other site 516950005633 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 516950005634 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 516950005635 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 516950005636 Enterocin A Immunity; Region: EntA_Immun; pfam08951 516950005637 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 516950005638 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 516950005639 oligomer interface [polypeptide binding]; other site 516950005640 active site 516950005641 metal binding site [ion binding]; metal-binding site 516950005642 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 516950005643 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 516950005644 NAD(P) binding site [chemical binding]; other site 516950005645 active site 516950005646 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 516950005647 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 516950005648 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 516950005649 ABC-ATPase subunit interface; other site 516950005650 dimer interface [polypeptide binding]; other site 516950005651 putative PBP binding regions; other site 516950005652 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 516950005653 ABC-ATPase subunit interface; other site 516950005654 dimer interface [polypeptide binding]; other site 516950005655 putative PBP binding regions; other site 516950005656 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 516950005657 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 516950005658 Walker A/P-loop; other site 516950005659 ATP binding site [chemical binding]; other site 516950005660 Q-loop/lid; other site 516950005661 ABC transporter signature motif; other site 516950005662 Walker B; other site 516950005663 D-loop; other site 516950005664 H-loop/switch region; other site 516950005665 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 516950005666 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 516950005667 putative ligand binding residues [chemical binding]; other site 516950005668 hypothetical protein; Validated; Region: PRK00041 516950005669 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 516950005670 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 516950005671 RNA binding surface [nucleotide binding]; other site 516950005672 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 516950005673 active site 516950005674 segregation and condensation protein B; Reviewed; Region: scpB; PRK00135 516950005675 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 516950005676 site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436 516950005677 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 516950005678 DNA binding site [nucleotide binding] 516950005679 Int/Topo IB signature motif; other site 516950005680 active site 516950005681 catalytic residues [active] 516950005682 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643 516950005683 FOG: CBS domain [General function prediction only]; Region: COG0517 516950005684 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 516950005685 active site 516950005686 metal binding site [ion binding]; metal-binding site 516950005687 homotetramer interface [polypeptide binding]; other site 516950005688 putative deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein; Reviewed; Region: PRK02491 516950005689 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 516950005690 active site 516950005691 dimerization interface [polypeptide binding]; other site 516950005692 glutamate racemase; Provisional; Region: PRK00865 516950005693 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 516950005694 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 516950005695 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 516950005696 Ca binding site [ion binding]; other site 516950005697 active site 516950005698 catalytic site [active] 516950005699 PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992 516950005700 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 516950005701 active site turn [active] 516950005702 phosphorylation site [posttranslational modification] 516950005703 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 516950005704 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 516950005705 HPr interaction site; other site 516950005706 glycerol kinase (GK) interaction site [polypeptide binding]; other site 516950005707 active site 516950005708 phosphorylation site [posttranslational modification] 516950005709 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 516950005710 DNA-binding site [nucleotide binding]; DNA binding site 516950005711 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 516950005712 UTRA domain; Region: UTRA; pfam07702 516950005713 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 516950005714 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 516950005715 Transposase; Region: DDE_Tnp_ISL3; pfam01610 516950005716 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 516950005717 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 516950005718 Walker A/P-loop; other site 516950005719 ATP binding site [chemical binding]; other site 516950005720 Q-loop/lid; other site 516950005721 ABC transporter signature motif; other site 516950005722 Walker B; other site 516950005723 D-loop; other site 516950005724 H-loop/switch region; other site 516950005725 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 516950005726 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 516950005727 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 516950005728 Walker A/P-loop; other site 516950005729 ATP binding site [chemical binding]; other site 516950005730 Q-loop/lid; other site 516950005731 ABC transporter signature motif; other site 516950005732 Walker B; other site 516950005733 D-loop; other site 516950005734 H-loop/switch region; other site 516950005735 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 516950005736 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 516950005737 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 516950005738 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 516950005739 dimer interface [polypeptide binding]; other site 516950005740 conserved gate region; other site 516950005741 putative PBP binding loops; other site 516950005742 ABC-ATPase subunit interface; other site 516950005743 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 516950005744 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 516950005745 dimer interface [polypeptide binding]; other site 516950005746 conserved gate region; other site 516950005747 putative PBP binding loops; other site 516950005748 ABC-ATPase subunit interface; other site 516950005749 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 516950005750 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 516950005751 peptide binding site [polypeptide binding]; other site 516950005752 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 516950005753 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 516950005754 sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852 516950005755 Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355 516950005756 active site 516950005757 homodimer interface [polypeptide binding]; other site 516950005758 catalytic site [active] 516950005759 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 516950005760 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 516950005761 dimer interface [polypeptide binding]; other site 516950005762 conserved gate region; other site 516950005763 putative PBP binding loops; other site 516950005764 ABC-ATPase subunit interface; other site 516950005765 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 516950005766 dimer interface [polypeptide binding]; other site 516950005767 conserved gate region; other site 516950005768 putative PBP binding loops; other site 516950005769 ABC-ATPase subunit interface; other site 516950005770 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 516950005771 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 516950005772 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 516950005773 Melibiase; Region: Melibiase; pfam02065 516950005774 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 516950005775 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 516950005776 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 516950005777 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 516950005778 Biotin operon repressor [Transcription]; Region: BirA; COG1654 516950005779 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 516950005780 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 516950005781 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 516950005782 TRAM domain; Region: TRAM; pfam01938 516950005783 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 516950005784 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 516950005785 S-adenosylmethionine binding site [chemical binding]; other site 516950005786 Aminoglycoside 3'-phosphotransferase (APH). The APH subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin...; Region: APH; cd05150 516950005787 active site 516950005788 Phosphotransferase enzyme family; Region: APH; pfam01636 516950005789 ATP binding site [chemical binding]; other site 516950005790 antibiotic binding site [chemical binding]; other site 516950005791 recombination regulator RecX; Provisional; Region: recX; PRK14135 516950005792 hypothetical protein; Provisional; Region: PRK13662 516950005793 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 516950005794 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 516950005795 Transposase; Region: DDE_Tnp_ISL3; pfam01610 516950005796 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 516950005797 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 516950005798 ring oligomerisation interface [polypeptide binding]; other site 516950005799 ATP/Mg binding site [chemical binding]; other site 516950005800 stacking interactions; other site 516950005801 hinge regions; other site 516950005802 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 516950005803 oligomerisation interface [polypeptide binding]; other site 516950005804 mobile loop; other site 516950005805 roof hairpin; other site 516950005806 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 516950005807 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 516950005808 dimer interface [polypeptide binding]; other site 516950005809 ssDNA binding site [nucleotide binding]; other site 516950005810 tetramer (dimer of dimers) interface [polypeptide binding]; other site 516950005811 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 516950005812 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 516950005813 putative NAD(P) binding site [chemical binding]; other site 516950005814 homodimer interface [polypeptide binding]; other site 516950005815 homotetramer interface [polypeptide binding]; other site 516950005816 active site 516950005817 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 516950005818 putative tRNA-binding site [nucleotide binding]; other site 516950005819 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 516950005820 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 516950005821 catalytic residues [active] 516950005822 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 516950005823 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 516950005824 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 516950005825 LytTr DNA-binding domain; Region: LytTR; pfam04397 516950005826 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 516950005827 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 516950005828 active site 516950005829 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4898 516950005830 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 516950005831 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 516950005832 Walker A/P-loop; other site 516950005833 ATP binding site [chemical binding]; other site 516950005834 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 516950005835 Walker A/P-loop; other site 516950005836 ATP binding site [chemical binding]; other site 516950005837 Q-loop/lid; other site 516950005838 ABC transporter signature motif; other site 516950005839 Walker B; other site 516950005840 D-loop; other site 516950005841 H-loop/switch region; other site 516950005842 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 516950005843 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 516950005844 MarR family; Region: MarR_2; pfam12802 516950005845 Transcriptional regulators [Transcription]; Region: MarR; COG1846 516950005846 hypothetical protein; Provisional; Region: PRK12378 516950005847 Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289 516950005848 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 516950005849 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 516950005850 Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405 516950005851 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 516950005852 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 516950005853 non-specific DNA binding site [nucleotide binding]; other site 516950005854 salt bridge; other site 516950005855 sequence-specific DNA binding site [nucleotide binding]; other site 516950005856 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 516950005857 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 516950005858 amidase catalytic site [active] 516950005859 Zn binding residues [ion binding]; other site 516950005860 substrate binding site [chemical binding]; other site 516950005861 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 516950005862 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 516950005863 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 516950005864 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 516950005865 recombinase A; Provisional; Region: recA; PRK09354 516950005866 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 516950005867 hexamer interface [polypeptide binding]; other site 516950005868 Walker A motif; other site 516950005869 ATP binding site [chemical binding]; other site 516950005870 Walker B motif; other site 516950005871 competence damage-inducible protein A; Provisional; Region: PRK00549 516950005872 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 516950005873 putative MPT binding site; other site 516950005874 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 516950005875 Transcriptional regulator [Transcription]; Region: LytR; COG1316 516950005876 putative acetyltransferase YhhY; Provisional; Region: PRK10140 516950005877 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 516950005878 Coenzyme A binding pocket [chemical binding]; other site 516950005879 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 516950005880 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 516950005881 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 516950005882 non-specific DNA binding site [nucleotide binding]; other site 516950005883 salt bridge; other site 516950005884 sequence-specific DNA binding site [nucleotide binding]; other site 516950005885 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 516950005886 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 516950005887 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 516950005888 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 516950005889 Walker A/P-loop; other site 516950005890 ATP binding site [chemical binding]; other site 516950005891 Q-loop/lid; other site 516950005892 ABC transporter signature motif; other site 516950005893 Walker B; other site 516950005894 D-loop; other site 516950005895 H-loop/switch region; other site 516950005896 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 516950005897 active site 516950005898 multimer interface [polypeptide binding]; other site 516950005899 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 516950005900 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 516950005901 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 516950005902 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 516950005903 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 516950005904 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 516950005905 Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site 516950005906 G-loop; other site 516950005907 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 516950005908 DNA binding site [nucleotide binding] 516950005909 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 516950005910 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 516950005911 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 516950005912 RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385 516950005913 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 516950005914 RPB1 interaction site [polypeptide binding]; other site 516950005915 RPB10 interaction site [polypeptide binding]; other site 516950005916 RPB11 interaction site [polypeptide binding]; other site 516950005917 RPB3 interaction site [polypeptide binding]; other site 516950005918 RPB12 interaction site [polypeptide binding]; other site 516950005919 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 516950005920 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 516950005921 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 516950005922 Domain of unknown function DUF21; Region: DUF21; pfam01595 516950005923 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 516950005924 Transporter associated domain; Region: CorC_HlyC; smart01091 516950005925 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 516950005926 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; pfam01223 516950005927 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 516950005928 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 516950005929 hinge; other site 516950005930 active site 516950005931 Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480 516950005932 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 516950005933 protein binding site [polypeptide binding]; other site 516950005934 Phosphopantetheine adenylyltransferase [Coenzyme metabolism]; Region: CoaD; COG0669 516950005935 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 516950005936 active site 516950005937 (T/H)XGH motif; other site 516950005938 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 516950005939 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 516950005940 S-adenosylmethionine binding site [chemical binding]; other site 516950005941 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 516950005942 dimer interface [polypeptide binding]; other site 516950005943 active site 516950005944 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 516950005945 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 516950005946 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 516950005947 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 516950005948 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 516950005949 acylphosphatase; Provisional; Region: PRK14434 516950005950 OxaA-like protein precursor; Provisional; Region: PRK02463 516950005951 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 516950005952 pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493 516950005953 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 516950005954 FeS/SAM binding site; other site 516950005955 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 516950005956 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 516950005957 active site 516950005958 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 516950005959 substrate binding site [chemical binding]; other site 516950005960 catalytic residues [active] 516950005961 dimer interface [polypeptide binding]; other site 516950005962 pur operon repressor; Provisional; Region: PRK09213 516950005963 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 516950005964 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 516950005965 active site 516950005966 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 516950005967 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 516950005968 generic binding surface II; other site 516950005969 generic binding surface I; other site 516950005970 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 516950005971 Zn2+ binding site [ion binding]; other site 516950005972 Mg2+ binding site [ion binding]; other site 516950005973 Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322 516950005974 RmuC family; Region: RmuC; pfam02646 516950005975 Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564 516950005976 Thiamine pyrophosphokinase; Region: TPK; cd07995 516950005977 active site 516950005978 dimerization interface [polypeptide binding]; other site 516950005979 thiamine binding site [chemical binding]; other site 516950005980 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 516950005981 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 516950005982 substrate binding site [chemical binding]; other site 516950005983 hexamer interface [polypeptide binding]; other site 516950005984 metal binding site [ion binding]; metal-binding site 516950005985 GTPase RsgA; Reviewed; Region: PRK00098 516950005986 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 516950005987 RNA binding site [nucleotide binding]; other site 516950005988 homodimer interface [polypeptide binding]; other site 516950005989 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 516950005990 GTPase/Zn-binding domain interface [polypeptide binding]; other site 516950005991 GTP/Mg2+ binding site [chemical binding]; other site 516950005992 G4 box; other site 516950005993 G5 box; other site 516950005994 G1 box; other site 516950005995 Switch I region; other site 516950005996 G2 box; other site 516950005997 G3 box; other site 516950005998 Switch II region; other site 516950005999 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 516950006000 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 516950006001 S-adenosylmethionine binding site [chemical binding]; other site 516950006002 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 516950006003 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 516950006004 Walker A/P-loop; other site 516950006005 ATP binding site [chemical binding]; other site 516950006006 Q-loop/lid; other site 516950006007 ABC transporter signature motif; other site 516950006008 Walker B; other site 516950006009 D-loop; other site 516950006010 H-loop/switch region; other site 516950006011 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652 516950006012 Protein of unknown function (DUF1430); Region: DUF1430; pfam07242 516950006013 Bacteriocin (Lactococcin_972); Region: Lactococcin_972; cl09891 516950006014 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 516950006015 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 516950006016 non-specific DNA binding site [nucleotide binding]; other site 516950006017 salt bridge; other site 516950006018 sequence-specific DNA binding site [nucleotide binding]; other site 516950006019 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 516950006020 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 516950006021 putative active site [active] 516950006022 putative metal binding site [ion binding]; other site 516950006023 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 516950006024 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 516950006025 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 516950006026 active site 516950006027 Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564 516950006028 Ribosomal protein L34; Region: Ribosomal_L34; cl00370 516950006029 aminotransferase AlaT; Validated; Region: PRK09265 516950006030 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 516950006031 pyridoxal 5'-phosphate binding site [chemical binding]; other site 516950006032 homodimer interface [polypeptide binding]; other site 516950006033 catalytic residue [active] 516950006034 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 516950006035 Ligand Binding Site [chemical binding]; other site 516950006036 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 516950006037 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 516950006038 active site 516950006039 motif I; other site 516950006040 motif II; other site 516950006041 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 516950006042 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545 516950006043 putative nucleotide binding site [chemical binding]; other site 516950006044 putative metal binding site [ion binding]; other site 516950006045 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 516950006046 active site 516950006047 homotetramer interface [polypeptide binding]; other site 516950006048 homodimer interface [polypeptide binding]; other site 516950006049 catabolite control protein A; Region: ccpA; TIGR01481 516950006050 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 516950006051 DNA binding site [nucleotide binding] 516950006052 domain linker motif; other site 516950006053 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 516950006054 dimerization interface [polypeptide binding]; other site 516950006055 effector binding site; other site 516950006056 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 516950006057 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 516950006058 active site 516950006059 phosphorylation site [posttranslational modification] 516950006060 intermolecular recognition site; other site 516950006061 dimerization interface [polypeptide binding]; other site 516950006062 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 516950006063 DNA binding residues [nucleotide binding] 516950006064 dimerization interface [polypeptide binding]; other site 516950006065 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 516950006066 Histidine kinase; Region: HisKA_3; pfam07730 516950006067 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 516950006068 ATP binding site [chemical binding]; other site 516950006069 Mg2+ binding site [ion binding]; other site 516950006070 G-X-G motif; other site 516950006071 ABC-2 type transporter; Region: ABC2_membrane; cl17235 516950006072 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 516950006073 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 516950006074 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 516950006075 Walker A/P-loop; other site 516950006076 ATP binding site [chemical binding]; other site 516950006077 Q-loop/lid; other site 516950006078 ABC transporter signature motif; other site 516950006079 Walker B; other site 516950006080 D-loop; other site 516950006081 H-loop/switch region; other site 516950006082 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 516950006083 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 516950006084 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 516950006085 putative homodimer interface [polypeptide binding]; other site 516950006086 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 516950006087 heterodimer interface [polypeptide binding]; other site 516950006088 homodimer interface [polypeptide binding]; other site 516950006089 Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690 516950006090 Helix-turn-helix domain; Region: HTH_28; pfam13518 516950006091 Winged helix-turn helix; Region: HTH_29; pfam13551 516950006092 Homeodomain-like domain; Region: HTH_32; pfam13565 516950006093 Integrase core domain; Region: rve; pfam00665 516950006094 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 516950006095 Transglycosylase; Region: Transgly; pfam00912 516950006096 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 516950006097 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 516950006098 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 516950006099 active site 516950006100 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 516950006101 Transposase; Region: DDE_Tnp_ISL3; pfam01610 516950006102 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 516950006103 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 516950006104 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 516950006105 FtsX-like permease family; Region: FtsX; pfam02687 516950006106 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 516950006107 DDE superfamily endonuclease; Region: DDE_3; pfam13358 516950006108 Transposase; Region: HTH_Tnp_IS630; pfam01710 516950006109 Helix-turn-helix domain; Region: HTH_28; pfam13518 516950006110 nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06559 516950006111 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 516950006112 dimerization interface [polypeptide binding]; other site 516950006113 active site 516950006114 Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158 516950006115 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 516950006116 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 516950006117 Walker A/P-loop; other site 516950006118 ATP binding site [chemical binding]; other site 516950006119 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 516950006120 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 516950006121 DNA-binding site [nucleotide binding]; DNA binding site 516950006122 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 516950006123 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 516950006124 beta-galactosidase; Region: BGL; TIGR03356 516950006125 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 516950006126 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 516950006127 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 516950006128 active site 516950006129 P-loop; other site 516950006130 phosphorylation site [posttranslational modification] 516950006131 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 516950006132 methionine cluster; other site 516950006133 active site 516950006134 phosphorylation site [posttranslational modification] 516950006135 metal binding site [ion binding]; metal-binding site 516950006136 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 516950006137 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 516950006138 putative catalytic cysteine [active] 516950006139 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 516950006140 putative active site [active] 516950006141 metal binding site [ion binding]; metal-binding site 516950006142 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 516950006143 MORN repeat; Region: MORN; cl14787 516950006144 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 516950006145 Low molecular weight phosphatase family; Region: LMWPc; cd00115 516950006146 active site 516950006147 preprotein translocase subunit YajC; Validated; Region: yajC; PRK06531 516950006148 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 516950006149 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 516950006150 TPP-binding site [chemical binding]; other site 516950006151 dimer interface [polypeptide binding]; other site 516950006152 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 516950006153 PYR/PP interface [polypeptide binding]; other site 516950006154 dimer interface [polypeptide binding]; other site 516950006155 TPP binding site [chemical binding]; other site 516950006156 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 516950006157 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 516950006158 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 516950006159 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 516950006160 PRD domain; Region: PRD; pfam00874 516950006161 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 516950006162 active site 516950006163 P-loop; other site 516950006164 phosphorylation site [posttranslational modification] 516950006165 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 516950006166 L-ribulose-5-phosphate 4-epimerase; Provisional; Region: araD; PRK13145 516950006167 intersubunit interface [polypeptide binding]; other site 516950006168 active site 516950006169 Zn2+ binding site [ion binding]; other site 516950006170 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 516950006171 Metal-binding active site; metal-binding site 516950006172 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 516950006173 AP (apurinic/apyrimidinic) site pocket; other site 516950006174 DNA interaction; other site 516950006175 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 516950006176 active site 516950006177 dimer interface [polypeptide binding]; other site 516950006178 magnesium binding site [ion binding]; other site 516950006179 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 516950006180 active site 516950006181 phosphorylation site [posttranslational modification] 516950006182 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 516950006183 active site 516950006184 P-loop; other site 516950006185 phosphorylation site [posttranslational modification] 516950006186 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997 516950006187 Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847 516950006188 jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation. The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414 516950006189 G-X-X-G motif; other site 516950006190 R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644 516950006191 RxxxH motif; other site 516950006192 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 516950006193 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 516950006194 ribonuclease P; Reviewed; Region: rnpA; PRK00499 516950006195 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 516950006196 propionate/acetate kinase; Provisional; Region: PRK12379 516950006197 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 516950006198 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 516950006199 S-adenosylmethionine binding site [chemical binding]; other site 516950006200 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 516950006201 Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940 516950006202 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 516950006203 Type II secretory pathway pseudopilin; Region: PulG; pfam11773 516950006204 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 516950006205 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 516950006206 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 516950006207 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 516950006208 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 516950006209 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 516950006210 Walker A motif; other site 516950006211 ATP binding site [chemical binding]; other site 516950006212 Walker B motif; other site 516950006213 Protein of unknown function (DUF1033); Region: DUF1033; pfam06279 516950006214 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286 516950006215 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 516950006216 catalytic Zn binding site [ion binding]; other site 516950006217 structural Zn binding site [ion binding]; other site 516950006218 NAD(P) binding site [chemical binding]; other site 516950006219 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 516950006220 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 516950006221 active site 516950006222 dimer interface [polypeptide binding]; other site 516950006223 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 516950006224 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 516950006225 catalytic triad [active] 516950006226 catalytic triad [active] 516950006227 oxyanion hole [active] 516950006228 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 516950006229 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 516950006230 Predicted integral membrane protein [Function unknown]; Region: COG5523 516950006231 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 516950006232 putative substrate binding pocket [chemical binding]; other site 516950006233 AC domain interface; other site 516950006234 catalytic triad [active] 516950006235 AB domain interface; other site 516950006236 interchain disulfide; other site 516950006237 Predicted membrane protein [Function unknown]; Region: COG3759 516950006238 Transcriptional regulators [Transcription]; Region: MarR; COG1846 516950006239 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 516950006240 putative DNA binding site [nucleotide binding]; other site 516950006241 putative Zn2+ binding site [ion binding]; other site 516950006242 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 516950006243 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 516950006244 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 516950006245 motif II; other site 516950006246 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 516950006247 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 516950006248 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 516950006249 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 516950006250 pyridoxal 5'-phosphate binding site [chemical binding]; other site 516950006251 catalytic residue [active] 516950006252 Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572 516950006253 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 516950006254 active site 516950006255 catalytic motif [active] 516950006256 Zn binding site [ion binding]; other site 516950006257 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 516950006258 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 516950006259 active site 516950006260 HIGH motif; other site 516950006261 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 516950006262 active site 516950006263 KMSKS motif; other site 516950006264 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 516950006265 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 516950006266 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 516950006267 active site 516950006268 dimer interface [polypeptide binding]; other site 516950006269 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 516950006270 dimer interface [polypeptide binding]; other site 516950006271 active site 516950006272 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 516950006273 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 516950006274 catalytic triad [active] 516950006275 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 516950006276 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 516950006277 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 516950006278 Walker A/P-loop; other site 516950006279 ATP binding site [chemical binding]; other site 516950006280 Q-loop/lid; other site 516950006281 ABC transporter signature motif; other site 516950006282 Walker B; other site 516950006283 D-loop; other site 516950006284 H-loop/switch region; other site 516950006285 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 516950006286 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 516950006287 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 516950006288 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 516950006289 Walker A/P-loop; other site 516950006290 ATP binding site [chemical binding]; other site 516950006291 Q-loop/lid; other site 516950006292 ABC transporter signature motif; other site 516950006293 Walker B; other site 516950006294 D-loop; other site 516950006295 H-loop/switch region; other site 516950006296 DNA mismatch repair protein MutS; Region: mutS1; TIGR01070 516950006297 MutS domain I; Region: MutS_I; pfam01624 516950006298 MutS domain II; Region: MutS_II; pfam05188 516950006299 MutS domain III; Region: MutS_III; pfam05192 516950006300 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 516950006301 Walker A/P-loop; other site 516950006302 ATP binding site [chemical binding]; other site 516950006303 Q-loop/lid; other site 516950006304 ABC transporter signature motif; other site 516950006305 Walker B; other site 516950006306 D-loop; other site 516950006307 H-loop/switch region; other site 516950006308 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 516950006309 arginine repressor; Region: argR_whole; TIGR01529 516950006310 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 516950006311 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 516950006312 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 516950006313 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 516950006314 active site 516950006315 HIGH motif; other site 516950006316 KMSK motif region; other site 516950006317 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 516950006318 tRNA binding surface [nucleotide binding]; other site 516950006319 anticodon binding site; other site 516950006320 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 516950006321 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 516950006322 Uncharacterized conserved protein [Function unknown]; Region: COG3542 516950006323 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 516950006324 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 516950006325 active site 516950006326 phosphorylation site [posttranslational modification] 516950006327 intermolecular recognition site; other site 516950006328 dimerization interface [polypeptide binding]; other site 516950006329 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 516950006330 DNA binding site [nucleotide binding] 516950006331 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 516950006332 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 516950006333 dimer interface [polypeptide binding]; other site 516950006334 phosphorylation site [posttranslational modification] 516950006335 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 516950006336 ATP binding site [chemical binding]; other site 516950006337 G-X-G motif; other site 516950006338 PBP superfamily domain; Region: PBP_like_2; cl17296 516950006339 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 516950006340 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 516950006341 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 516950006342 dimer interface [polypeptide binding]; other site 516950006343 conserved gate region; other site 516950006344 putative PBP binding loops; other site 516950006345 ABC-ATPase subunit interface; other site 516950006346 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 516950006347 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 516950006348 dimer interface [polypeptide binding]; other site 516950006349 conserved gate region; other site 516950006350 putative PBP binding loops; other site 516950006351 ABC-ATPase subunit interface; other site 516950006352 phosphate transporter ATP-binding protein; Provisional; Region: PRK14240 516950006353 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 516950006354 Walker A/P-loop; other site 516950006355 ATP binding site [chemical binding]; other site 516950006356 Q-loop/lid; other site 516950006357 ABC transporter signature motif; other site 516950006358 Walker B; other site 516950006359 D-loop; other site 516950006360 H-loop/switch region; other site 516950006361 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 516950006362 PhoU domain; Region: PhoU; pfam01895 516950006363 PhoU domain; Region: PhoU; pfam01895 516950006364 DNA replication terminus site-binding protein (Ter protein); Region: Ter; cl11502 516950006365 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 516950006366 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 516950006367 non-specific DNA binding site [nucleotide binding]; other site 516950006368 salt bridge; other site 516950006369 sequence-specific DNA binding site [nucleotide binding]; other site 516950006370 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 516950006371 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 516950006372 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 516950006373 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 516950006374 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 516950006375 active site 516950006376 tetramer interface; other site 516950006377 Rhomboid family; Region: Rhomboid; pfam01694 516950006378 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 516950006379 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 516950006380 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 516950006381 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 516950006382 metal binding site [ion binding]; metal-binding site 516950006383 putative dimer interface [polypeptide binding]; other site 516950006384 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 516950006385 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 516950006386 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 516950006387 trimer interface [polypeptide binding]; other site 516950006388 active site 516950006389 substrate binding site [chemical binding]; other site 516950006390 CoA binding site [chemical binding]; other site 516950006391 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 516950006392 EamA-like transporter family; Region: EamA; pfam00892 516950006393 Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744 516950006394 Transglycosylase; Region: Transgly; pfam00912 516950006395 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 516950006396 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 516950006397 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 516950006398 active site 516950006399 HIGH motif; other site 516950006400 dimer interface [polypeptide binding]; other site 516950006401 KMSKS motif; other site 516950006402 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 516950006403 RNA binding surface [nucleotide binding]; other site 516950006404 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 516950006405 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 516950006406 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 516950006407 motif II; other site 516950006408 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 516950006409 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 516950006410 S-adenosylmethionine binding site [chemical binding]; other site 516950006411 glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093 516950006412 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 516950006413 4-alpha-glucanotransferase; Provisional; Region: PRK14508 516950006414 Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182 516950006415 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 516950006416 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 516950006417 dimer interface [polypeptide binding]; other site 516950006418 conserved gate region; other site 516950006419 putative PBP binding loops; other site 516950006420 ABC-ATPase subunit interface; other site 516950006421 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 516950006422 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 516950006423 dimer interface [polypeptide binding]; other site 516950006424 conserved gate region; other site 516950006425 putative PBP binding loops; other site 516950006426 ABC-ATPase subunit interface; other site 516950006427 Predicted integral membrane protein [Function unknown]; Region: COG5521 516950006428 Transcriptional regulators [Transcription]; Region: PurR; COG1609 516950006429 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 516950006430 DNA binding site [nucleotide binding] 516950006431 domain linker motif; other site 516950006432 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 516950006433 putative dimerization interface [polypeptide binding]; other site 516950006434 putative ligand binding site [chemical binding]; other site 516950006435 Uncharacterized conserved protein [Function unknown]; Region: COG1284 516950006436 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 516950006437 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 516950006438 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 516950006439 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 516950006440 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 516950006441 dimer interface [polypeptide binding]; other site 516950006442 anticodon binding site; other site 516950006443 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 516950006444 homodimer interface [polypeptide binding]; other site 516950006445 motif 1; other site 516950006446 active site 516950006447 motif 2; other site 516950006448 GAD domain; Region: GAD; pfam02938 516950006449 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 516950006450 motif 3; other site 516950006451 CAAX protease self-immunity; Region: Abi; pfam02517 516950006452 Protein of unknown function (DUF3169); Region: DUF3169; pfam11368 516950006453 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 516950006454 non-specific DNA binding site [nucleotide binding]; other site 516950006455 salt bridge; other site 516950006456 sequence-specific DNA binding site [nucleotide binding]; other site 516950006457 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 516950006458 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 516950006459 dimer interface [polypeptide binding]; other site 516950006460 motif 1; other site 516950006461 active site 516950006462 motif 2; other site 516950006463 motif 3; other site 516950006464 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 516950006465 anticodon binding site; other site 516950006466 Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701 516950006467 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 516950006468 non-specific DNA binding site [nucleotide binding]; other site 516950006469 salt bridge; other site 516950006470 sequence-specific DNA binding site [nucleotide binding]; other site 516950006471 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 516950006472 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 516950006473 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 516950006474 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 516950006475 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 516950006476 PYR/PP interface [polypeptide binding]; other site 516950006477 dimer interface [polypeptide binding]; other site 516950006478 TPP binding site [chemical binding]; other site 516950006479 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 516950006480 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 516950006481 TPP-binding site [chemical binding]; other site 516950006482 dimer interface [polypeptide binding]; other site 516950006483 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 516950006484 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 516950006485 active site 516950006486 P-loop; other site 516950006487 phosphorylation site [posttranslational modification] 516950006488 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 516950006489 PRD domain; Region: PRD; pfam00874 516950006490 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 516950006491 active site 516950006492 P-loop; other site 516950006493 phosphorylation site [posttranslational modification] 516950006494 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 516950006495 active site 516950006496 phosphorylation site [posttranslational modification] 516950006497 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 516950006498 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_2; cd03402 516950006499 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4877 516950006500 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 516950006501 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 516950006502 Leucine rich repeats (6 copies); Region: LRR_5; pfam13306 516950006503 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 516950006504 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 516950006505 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 516950006506 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 516950006507 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 516950006508 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 516950006509 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 516950006510 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 516950006511 Divergent AAA domain; Region: AAA_4; pfam04326 516950006512 DDE superfamily endonuclease; Region: DDE_4_2; pfam13613 516950006513 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293 516950006514 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 516950006515 putative active site [active] 516950006516 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 516950006517 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 516950006518 nucleotide binding site [chemical binding]; other site 516950006519 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 516950006520 N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814 516950006521 active site 516950006522 metal binding site [ion binding]; metal-binding site 516950006523 homodimer interface [polypeptide binding]; other site 516950006524 catalytic site [active] 516950006525 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 516950006526 Uncharacterized conserved protein [Function unknown]; Region: COG3538 516950006527 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 516950006528 Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537 516950006529 Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971 516950006530 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 516950006531 Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119 516950006532 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 516950006533 arginine deiminase; Provisional; Region: PRK01388 516950006534 ornithine carbamoyltransferase; Validated; Region: PRK02102 516950006535 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 516950006536 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 516950006537 carbamate kinase; Reviewed; Region: PRK12686 516950006538 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 516950006539 putative substrate binding site [chemical binding]; other site 516950006540 nucleotide binding site [chemical binding]; other site 516950006541 nucleotide binding site [chemical binding]; other site 516950006542 homodimer interface [polypeptide binding]; other site 516950006543 Predicted membrane protein [Function unknown]; Region: COG1288 516950006544 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 516950006545 hypothetical protein; Provisional; Region: PRK07205 516950006546 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 516950006547 active site 516950006548 metal binding site [ion binding]; metal-binding site 516950006549 YSIRK type signal peptide; Region: YSIRK_signal; pfam04650 516950006550 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 516950006551 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_4; cd03407 516950006552 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 516950006553 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 516950006554 dimer interface [polypeptide binding]; other site 516950006555 active site 516950006556 metal binding site [ion binding]; metal-binding site 516950006557 L-fucose isomerase; Provisional; Region: fucI; PRK10991 516950006558 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 516950006559 hexamer (dimer of trimers) interface [polypeptide binding]; other site 516950006560 trimer interface [polypeptide binding]; other site 516950006561 substrate binding site [chemical binding]; other site 516950006562 Mn binding site [ion binding]; other site 516950006563 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 516950006564 intersubunit interface [polypeptide binding]; other site 516950006565 active site 516950006566 Zn2+ binding site [ion binding]; other site 516950006567 NPCBM/NEW2 domain; Region: NPCBM; pfam08305 516950006568 NPCBM/NEW2 domain; Region: NPCBM; pfam08305 516950006569 Glycosyl hydrolase family 98; Region: Glyco_hydro_98M; pfam08306 516950006570 Glycosyl hydrolase family 98 C-terminal domain; Region: Glyco_hydro_98C; pfam08307 516950006571 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 516950006572 Melibiase; Region: Melibiase; pfam02065 516950006573 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 516950006574 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 516950006575 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 516950006576 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 516950006577 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 516950006578 dimer interface [polypeptide binding]; other site 516950006579 conserved gate region; other site 516950006580 putative PBP binding loops; other site 516950006581 ABC-ATPase subunit interface; other site 516950006582 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 516950006583 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 516950006584 dimer interface [polypeptide binding]; other site 516950006585 conserved gate region; other site 516950006586 putative PBP binding loops; other site 516950006587 ABC-ATPase subunit interface; other site 516950006588 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 516950006589 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 516950006590 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 516950006591 N- and C-terminal domain interface [polypeptide binding]; other site 516950006592 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 516950006593 active site 516950006594 putative catalytic site [active] 516950006595 metal binding site [ion binding]; metal-binding site 516950006596 ATP binding site [chemical binding]; other site 516950006597 carbohydrate binding site [chemical binding]; other site 516950006598 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 516950006599 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 516950006600 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 516950006601 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 516950006602 Metal binding protein AcdA. These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017 516950006603 metal binding site [ion binding]; metal-binding site 516950006604 YodA lipocalin-like domain; Region: YodA; pfam09223 516950006605 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 516950006606 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 516950006607 ABC-ATPase subunit interface; other site 516950006608 dimer interface [polypeptide binding]; other site 516950006609 putative PBP binding regions; other site 516950006610 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 516950006611 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 516950006612 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 516950006613 putative DNA binding site [nucleotide binding]; other site 516950006614 Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966 516950006615 DltD N-terminal region; Region: DltD_N; pfam04915 516950006616 DltD central region; Region: DltD_M; pfam04918 516950006617 DltD C-terminal region; Region: DltD_C; pfam04914 516950006618 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 516950006619 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 516950006620 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 516950006621 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 516950006622 acyl-activating enzyme (AAE) consensus motif; other site 516950006623 AMP binding site [chemical binding]; other site 516950006624 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 516950006625 H+ Antiporter protein; Region: 2A0121; TIGR00900 516950006626 putative substrate translocation pore; other site 516950006627 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 516950006628 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 516950006629 putative active site [active] 516950006630 putative NTP binding site [chemical binding]; other site 516950006631 putative nucleic acid binding site [nucleotide binding]; other site 516950006632 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 516950006633 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 516950006634 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 516950006635 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 516950006636 amphipathic channel; other site 516950006637 Asn-Pro-Ala signature motifs; other site 516950006638 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 516950006639 glycerol kinase; Provisional; Region: glpK; PRK00047 516950006640 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 516950006641 N- and C-terminal domain interface [polypeptide binding]; other site 516950006642 active site 516950006643 MgATP binding site [chemical binding]; other site 516950006644 catalytic site [active] 516950006645 metal binding site [ion binding]; metal-binding site 516950006646 glycerol binding site [chemical binding]; other site 516950006647 homotetramer interface [polypeptide binding]; other site 516950006648 homodimer interface [polypeptide binding]; other site 516950006649 FBP binding site [chemical binding]; other site 516950006650 protein IIAGlc interface [polypeptide binding]; other site 516950006651 Mga helix-turn-helix domain; Region: Mga; pfam05043 516950006652 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 516950006653 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 516950006654 dimerization interface [polypeptide binding]; other site 516950006655 domain crossover interface; other site 516950006656 redox-dependent activation switch; other site 516950006657 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 516950006658 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 516950006659 FMN binding site [chemical binding]; other site 516950006660 active site 516950006661 catalytic residues [active] 516950006662 substrate binding site [chemical binding]; other site 516950006663 Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168 516950006664 RICH domain; Region: RICH; pfam05062 516950006665 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 516950006666 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 516950006667 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 516950006668 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 516950006669 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 516950006670 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 516950006671 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 516950006672 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 516950006673 glucan-binding repeat; Region: glucan_65_rpt; TIGR04035 516950006674 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 516950006675 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755 516950006676 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 516950006677 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 516950006678 dimerization interface [polypeptide binding]; other site 516950006679 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 516950006680 dimer interface [polypeptide binding]; other site 516950006681 phosphorylation site [posttranslational modification] 516950006682 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 516950006683 ATP binding site [chemical binding]; other site 516950006684 Mg2+ binding site [ion binding]; other site 516950006685 G-X-G motif; other site 516950006686 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 516950006687 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 516950006688 active site 516950006689 phosphorylation site [posttranslational modification] 516950006690 intermolecular recognition site; other site 516950006691 dimerization interface [polypeptide binding]; other site 516950006692 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 516950006693 DNA binding site [nucleotide binding] 516950006694 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 516950006695 Clp amino terminal domain; Region: Clp_N; pfam02861 516950006696 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 516950006697 Walker A motif; other site 516950006698 ATP binding site [chemical binding]; other site 516950006699 Walker B motif; other site 516950006700 arginine finger; other site 516950006701 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 516950006702 Walker A motif; other site 516950006703 ATP binding site [chemical binding]; other site 516950006704 Walker B motif; other site 516950006705 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 516950006706 Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463 516950006707 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 516950006708 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 516950006709 Walker A/P-loop; other site 516950006710 ATP binding site [chemical binding]; other site 516950006711 Q-loop/lid; other site 516950006712 ABC transporter signature motif; other site 516950006713 Walker B; other site 516950006714 D-loop; other site 516950006715 H-loop/switch region; other site 516950006716 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 516950006717 NMT1/THI5 like; Region: NMT1; pfam09084 516950006718 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 516950006719 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 516950006720 Uncharacterized conserved protein [Function unknown]; Region: COG0011 516950006721 Surface antigen [General function prediction only]; Region: COG3942 516950006722 CHAP domain; Region: CHAP; pfam05257 516950006723 Bacterial SH3 domain; Region: SH3_5; pfam08460 516950006724 FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263 516950006725 Bacterial SH3 domain; Region: SH3_5; pfam08460 516950006726 Putative cell wall binding repeat; Region: CW_binding_1; pfam01473 516950006727 Uncharacterized protein conserved in bacteria [Function unknown]; Region: Veg; COG4466 516950006728 replicative DNA helicase; Provisional; Region: PRK05748 516950006729 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 516950006730 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 516950006731 Walker A motif; other site 516950006732 ATP binding site [chemical binding]; other site 516950006733 Walker B motif; other site 516950006734 DNA binding loops [nucleotide binding] 516950006735 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 516950006736 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 516950006737 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 516950006738 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 516950006739 DHH family; Region: DHH; pfam01368 516950006740 DHHA1 domain; Region: DHHA1; pfam02272 516950006741 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 516950006742 30S subunit binding site; other site 516950006743 comF family protein; Region: comF; TIGR00201 516950006744 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 516950006745 active site 516950006746 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 516950006747 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 516950006748 ATP binding site [chemical binding]; other site 516950006749 putative Mg++ binding site [ion binding]; other site 516950006750 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 516950006751 nucleotide binding region [chemical binding]; other site 516950006752 ATP-binding site [chemical binding]; other site 516950006753 Uncharacterized conserved protein [Function unknown]; Region: COG1739 516950006754 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 516950006755 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 516950006756 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 516950006757 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 516950006758 dimer interface [polypeptide binding]; other site 516950006759 pyridoxal 5'-phosphate binding site [chemical binding]; other site 516950006760 catalytic residue [active] 516950006761 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 516950006762 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 516950006763 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 516950006764 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 516950006765 elongation factor Ts; Provisional; Region: tsf; PRK09377 516950006766 UBA/TS-N domain; Region: UBA; pfam00627 516950006767 Elongation factor TS; Region: EF_TS; pfam00889 516950006768 Elongation factor TS; Region: EF_TS; pfam00889 516950006769 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 516950006770 rRNA interaction site [nucleotide binding]; other site 516950006771 S8 interaction site; other site 516950006772 putative laminin-1 binding site; other site 516950006773 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883 516950006774 Septum formation initiator; Region: DivIC; cl17659 516950006775 Surface antigen [General function prediction only]; Region: COG3942 516950006776 CHAP domain; Region: CHAP; pfam05257 516950006777 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891 516950006778 Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792 516950006779 rod shape-determining protein MreC; Region: MreC; pfam04085 516950006780 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 516950006781 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13649 516950006782 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 516950006783 Walker A/P-loop; other site 516950006784 ATP binding site [chemical binding]; other site 516950006785 Q-loop/lid; other site 516950006786 ABC transporter signature motif; other site 516950006787 Walker B; other site 516950006788 D-loop; other site 516950006789 H-loop/switch region; other site 516950006790 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13650 516950006791 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 516950006792 Walker A/P-loop; other site 516950006793 ATP binding site [chemical binding]; other site 516950006794 Q-loop/lid; other site 516950006795 ABC transporter signature motif; other site 516950006796 Walker B; other site 516950006797 D-loop; other site 516950006798 H-loop/switch region; other site 516950006799 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 516950006800 Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426 516950006801 Helix-turn-helix domain; Region: HTH_25; pfam13413 516950006802 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 516950006803 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 516950006804 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 516950006805 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 516950006806 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 516950006807 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 516950006808 S4-like RNA binding protein [Replication, recombination, and repair]; Region: COG2501 516950006809 Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195 516950006810 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 516950006811 Walker A/P-loop; other site 516950006812 ATP binding site [chemical binding]; other site 516950006813 Q-loop/lid; other site 516950006814 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 516950006815 ABC transporter signature motif; other site 516950006816 Walker B; other site 516950006817 D-loop; other site 516950006818 H-loop/switch region; other site 516950006819 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 516950006820 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 516950006821 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 516950006822 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 516950006823 active site 516950006824 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 516950006825 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 516950006826 active site 516950006827 HIGH motif; other site 516950006828 dimer interface [polypeptide binding]; other site 516950006829 KMSKS motif; other site 516950006830 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 516950006831 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 516950006832 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 516950006833 ABC transporter; Region: ABC_tran_2; pfam12848 516950006834 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 516950006835 Predicted membrane protein [Function unknown]; Region: COG4485 516950006836 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 516950006837 Predicted membrane protein [Function unknown]; Region: COG1511 516950006838 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 516950006839 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 516950006840 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 516950006841 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 516950006842 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 516950006843 active site 516950006844 phosphorylation site [posttranslational modification] 516950006845 intermolecular recognition site; other site 516950006846 dimerization interface [polypeptide binding]; other site 516950006847 LytTr DNA-binding domain; Region: LytTR; pfam04397 516950006848 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 516950006849 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 516950006850 COMC family; Region: ComC; pfam03047 516950006851 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 516950006852 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 516950006853 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 516950006854 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 516950006855 protein binding site [polypeptide binding]; other site 516950006856 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 516950006857 ParB-like nuclease domain; Region: ParBc; pfam02195 516950006858 KorB domain; Region: KorB; pfam08535