-- dump date 20140620_084513 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GI -- field 3 GeneID -- field 4 chrom_position -- field 5 chromosome -- field 6 codon_start -- field 7 contig -- field 8 description -- field 9 end_pos -- field 10 gene -- field 11 gene_id -- field 12 name -- field 13 organism -- field 14 product -- field 15 protein_id -- field 16 start_pos -- field 17 strand -- field 18 taxid -- field 19 type -- header -- id GI GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type YP_815417.1 116516053 4442762 1..1362 1 NC_008533.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 1362 dnaA 4442762 dnaA Streptococcus pneumoniae D39 chromosomal replication initiation protein YP_815417.1 1 D 373153 CDS YP_815419.1 116516939 4442015 1521..2657 1 NC_008533.1 binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 2657 dnaN 4442015 dnaN Streptococcus pneumoniae D39 DNA polymerase III subunit beta YP_815419.1 1521 D 373153 CDS YP_815421.1 116515850 4441542 2722..2916 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0003; equivalent gene in S.pneumoniae R6 = spr0003; identified by match to protein family HMM PF06107; hypothetical protein 2916 4441542 SPD_0003 Streptococcus pneumoniae D39 hypothetical protein YP_815421.1 2722 D 373153 CDS YP_815423.1 116516338 4442821 3000..4115 1 NC_008533.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 4115 4442821 SPD_0004 Streptococcus pneumoniae D39 GTP-dependent nucleic acid-binding protein EngD YP_815423.1 3000 D 373153 CDS YP_815426.1 116515731 4441019 4186..4755 1 NC_008533.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 4755 pth 4441019 pth Streptococcus pneumoniae D39 peptidyl-tRNA hydrolase YP_815426.1 4186 D 373153 CDS YP_815427.1 116516151 4442513 4756..8265 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0006; equivalent gene in S.pneumoniae R6 = spr0006; identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM PF02559; match to protein family HMM PF03461; match to protein family HMM PF04851; match to protein family HMM TIGR00580; transcription-repair coupling factor 8265 mfd 4442513 mfd Streptococcus pneumoniae D39 transcription-repair coupling factor YP_815427.1 4756 D 373153 CDS YP_815429.1 116515542 4442715 8323..8589 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0007; equivalent gene in S.pneumoniae R6 = spr0007; identified by match to protein family HMM PF01479; S4 domain-containing protein 8589 4442715 SPD_0007 Streptococcus pneumoniae D39 S4 domain-containing protein YP_815429.1 8323 D 373153 CDS YP_815431.1 116515979 4442430 8582..8950 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0008; equivalent gene in S.pneumoniae R6 = spr0008; identified by match to protein family HMM PF04977; hypothetical protein 8950 4442430 SPD_0008 Streptococcus pneumoniae D39 hypothetical protein YP_815431.1 8582 D 373153 CDS YP_815432.1 116516840 4442160 8955..9077 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0009; hypothetical protein 9077 4442160 SPD_0009 Streptococcus pneumoniae D39 hypothetical protein YP_815432.1 8955 D 373153 CDS YP_815433.1 116515953 4441394 9070..10338 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0010; equivalent gene in S.pneumoniae R6 = spr0009; hypothetical protein 10338 4441394 SPD_0010 Streptococcus pneumoniae D39 hypothetical protein YP_815433.1 9070 D 373153 CDS YP_815434.1 116516781 4442234 10335..11612 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0011; equivalent gene in S.pneumoniae R6 = spr0010; identified by match to protein family HMM PF01171; match to protein family HMM TIGR02432; match to protein family HMM TIGR02433; tRNA(Ile)-lysidine synthetase 11612 tilS 4442234 tilS Streptococcus pneumoniae D39 tRNA(Ile)-lysidine synthetase YP_815434.1 10335 D 373153 CDS YP_815435.1 116516681 4441355 11616..12158 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0012; equivalent gene in S.pneumoniae R6 = spr0011; identified by match to protein family HMM PF00156; match to protein family HMM TIGR01203; hypoxanthine-guanine phosphoribosyltransferase 12158 hpt 4441355 hpt Streptococcus pneumoniae D39 hypoxanthine-guanine phosphoribosyltransferase YP_815435.1 11616 D 373153 CDS YP_815436.1 116515587 4441207 12174..14132 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0013; equivalent gene in S.pneumoniae R6 = spr0012; identified by match to protein family HMM PF00004; match to protein family HMM PF01434; match to protein family HMM PF06480; match to protein family HMM TIGR01241; cell division protein FtsH 14132 ftsH 4441207 ftsH Streptococcus pneumoniae D39 cell division protein FtsH YP_815436.1 12174 D 373153 CDS YP_815437.1 116515336 4441078 14254..14733 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0014; equivalent gene in S.pneumoniae R6 = spr0013; transcriptional regulator ComX1 14733 comX1 4441078 comX1 Streptococcus pneumoniae D39 transcriptional regulator ComX1 YP_815437.1 14254 D 373153 CDS YP_815438.1 116515956 4441397 22168..22404 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0018; equivalent gene in S.pneumoniae R6 = spr0020; hypothetical protein 22404 4441397 SPD_0023 Streptococcus pneumoniae D39 hypothetical protein YP_815438.1 22168 D 373153 CDS YP_815439.1 116515772 4441672 22635..23921 1 NC_008533.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 23921 purA 4441672 purA Streptococcus pneumoniae D39 adenylosuccinate synthetase YP_815439.1 22635 D 373153 CDS YP_815440.1 116516620 4442398 24122..24589 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0020; equivalent gene in S.pneumoniae R6 = spr0022; identified by match to protein family HMM PF00383; cytidine/deoxycytidylate deaminase family protein 24589 4442398 SPD_0025 Streptococcus pneumoniae D39 cytidine/deoxycytidylate deaminase family protein YP_815440.1 24122 D 373153 CDS YP_815441.1 116515930 4441073 24776..25219 1 NC_008533.1 catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 25219 dut 4441073 dut Streptococcus pneumoniae D39 deoxyuridine 5'-triphosphate nucleotidohydrolase YP_815441.1 24776 D 373153 CDS YP_815442.1 116516859 4442141 25179..25736 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0022; equivalent gene in S.pneumoniae R6 = spr0024; identified by match to protein family HMM PF00300; hypothetical protein 25736 4442141 SPD_0028 Streptococcus pneumoniae D39 hypothetical protein YP_815442.1 25179 D 373153 CDS YP_815444.1 116516243 4441523 25849..27111 1 NC_008533.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 27111 radA 4441523 radA Streptococcus pneumoniae D39 DNA repair protein RadA YP_815444.1 25849 D 373153 CDS YP_815447.1 116515462 4441187 27184..27681 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0024; equivalent gene in S.pneumoniae R6 = spr0026; identified by match to protein family HMM PF00484; hypothetical protein 27681 4441187 SPD_0030 Streptococcus pneumoniae D39 hypothetical protein YP_815447.1 27184 D 373153 CDS YP_815449.1 116516295 4442584 27706..28365 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0026; equivalent gene in S.pneumoniae R6 = spr0027; hypothetical protein 28365 4442584 SPD_0031 Streptococcus pneumoniae D39 hypothetical protein YP_815449.1 27706 D 373153 CDS YP_815451.1 116515789 4441554 28358..28489 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0026; hypothetical protein 28489 4441554 SPD_0032 Streptococcus pneumoniae D39 hypothetical protein YP_815451.1 28358 D 373153 CDS YP_815453.1 116516609 4442386 28634..29602 1 NC_008533.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 29602 prsA 4442386 prsA Streptococcus pneumoniae D39 ribose-phosphate pyrophosphokinase YP_815453.1 28634 D 373153 CDS YP_815455.1 116516818 4442175 complement(30143..30376) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0029; equivalent gene in S.pneumoniae R6 = spr0030; hypothetical protein 30376 4442175 SPD_0035 Streptococcus pneumoniae D39 hypothetical protein YP_815455.1 30143 R 373153 CDS YP_815457.1 116516187 4441144 complement(30369..30485) 1 NC_008533.1 hypothetical protein 30485 4441144 SPD_0036 Streptococcus pneumoniae D39 hypothetical protein YP_815457.1 30369 R 373153 CDS YP_815459.1 116517001 4441985 complement(30700..31053) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0031; equivalent gene in S.pneumoniae R6 = spr0031; hypothetical protein 31053 4441985 SPD_0037 Streptococcus pneumoniae D39 hypothetical protein YP_815459.1 30700 R 373153 CDS YP_815461.1 116516654 4443058 31306..33939 1 NC_008533.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 33939 4443058 SPD_0038 Streptococcus pneumoniae D39 DNA polymerase I YP_815461.1 31306 D 373153 CDS YP_815463.1 116515315 4442658 34024..34461 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0033; equivalent gene in S.pneumoniae R6 = spr0033; identified by match to protein family HMM PF02629; hypothetical protein 34461 4442658 SPD_0039 Streptococcus pneumoniae D39 hypothetical protein YP_815463.1 34024 D 373153 CDS YP_815466.1 116516491 4443021 complement(34652..35662) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0034; equivalent gene in S.pneumoniae R6 = spr0034; identified by match to protein family HMM PF03601; hypothetical protein 35662 4443021 SPD_0040 Streptococcus pneumoniae D39 hypothetical protein YP_815466.1 34652 R 373153 CDS YP_815468.1 116516139 4442501 35811..36980 1 NC_008533.1 catalyzes the transamination of the aromatic amino acid forming a ketoacid; first step in aromatic amino acid degradation in lactococci; aromatic amino acid aminotransferase 36980 araT 4442501 araT Streptococcus pneumoniae D39 aromatic amino acid aminotransferase YP_815468.1 35811 D 373153 CDS YP_815471.1 116517190 4441827 36977..37747 1 NC_008533.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO 37747 recO 4441827 recO Streptococcus pneumoniae D39 DNA repair protein RecO YP_815471.1 36977 D 373153 CDS YP_815473.1 116515915 4441058 37744..38736 1 NC_008533.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; glycerol-3-phosphate acyltransferase PlsX 38736 plsX 4441058 plsX Streptococcus pneumoniae D39 glycerol-3-phosphate acyltransferase PlsX YP_815473.1 37744 D 373153 CDS YP_815476.1 116515605 4442744 38742..38975 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0038; equivalent gene in S.pneumoniae R6 = spr0038; acyl carrier protein 38975 4442744 SPD_0044 Streptococcus pneumoniae D39 acyl carrier protein YP_815476.1 38742 D 373153 CDS YP_815478.1 116516897 4442082 39514..39744 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0041; equivalent gene in S.pneumoniae R6 = spr0040; identified by match to protein family HMM TIGR01847; bacteriocin BlpU 39744 blpU 4442082 blpU Streptococcus pneumoniae D39 bacteriocin BlpU YP_815478.1 39514 D 373153 CDS YP_815481.1 116515804 4442850 39747..39872 1 NC_008533.1 hypothetical protein 39872 4442850 SPD_0047 Streptococcus pneumoniae D39 hypothetical protein YP_815481.1 39747 D 373153 CDS YP_815482.1 116516510 4442631 41902..44055 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0042; equivalent gene in S.pneumoniae R6 = spr0043; identified by match to protein family HMM PF00005; match to protein family HMM PF00664; match to protein family HMM PF03412; match to protein family HMM TIGR01193; competence factor transporting ATP-binding protein/permease ComA 44055 comA 4442631 comA Streptococcus pneumoniae D39 competence factor transporting ATP-binding protein/permease ComA YP_815482.1 41902 D 373153 CDS YP_815485.1 116515701 4441443 44068..45417 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0043; equivalent gene in S.pneumoniae R6 = spr0044; identified by match to protein family HMM TIGR01000; competence factor transport protein ComB 45417 comB 4441443 comB Streptococcus pneumoniae D39 competence factor transport protein ComB YP_815485.1 44068 D 373153 CDS YP_815487.1 116516190 4441147 45587..46294 1 NC_008533.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase 46294 purC 4441147 purC Streptococcus pneumoniae D39 phosphoribosylaminoimidazole-succinocarboxamide synthase YP_815487.1 45587 D 373153 CDS YP_815489.1 116516503 4442624 46496..50221 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0045; equivalent gene in S.pneumoniae R6 = spr0046; identified by match to protein family HMM PF02769; match to protein family HMM TIGR01857; phosphoribosylformylglycinamidine synthase 50221 4442624 SPD_0052 Streptococcus pneumoniae D39 phosphoribosylformylglycinamidine synthase YP_815489.1 46496 D 373153 CDS YP_815491.1 116515944 4441346 50314..51756 1 NC_008533.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 51756 purF 4441346 purF Streptococcus pneumoniae D39 amidophosphoribosyltransferase YP_815491.1 50314 D 373153 CDS YP_815493.1 116515735 4441023 51793..52815 1 NC_008533.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 52815 purM 4441023 purM Streptococcus pneumoniae D39 phosphoribosylaminoimidazole synthetase YP_815493.1 51793 D 373153 CDS YP_815495.1 116515802 4441567 52812..53357 1 NC_008533.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 53357 purN 4441567 purN Streptococcus pneumoniae D39 phosphoribosylglycinamide formyltransferase YP_815495.1 52812 D 373153 CDS YP_815498.1 116516890 4442075 53441..53950 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0049; equivalent gene in S.pneumoniae R6 = spr0050; identified by match to protein family HMM PF04892; vanZ protein 53950 4442075 SPD_0056 Streptococcus pneumoniae D39 vanZ protein YP_815498.1 53441 D 373153 CDS YP_815500.1 116516062 4442771 53975..55522 1 NC_008533.1 involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 55522 purH 4442771 purH Streptococcus pneumoniae D39 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase YP_815500.1 53975 D 373153 CDS YP_815502.1 116517132 4442370 55644..56906 1 NC_008533.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 56906 purD 4442370 purD Streptococcus pneumoniae D39 phosphoribosylamine--glycine ligase YP_815502.1 55644 D 373153 CDS YP_815504.1 116515776 4441676 57309..57797 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0053; equivalent gene in S.pneumoniae R6 = spr0053; identified by match to protein family HMM PF00731; match to protein family HMM TIGR01162; phosphoribosylaminoimidazole carboxylase catalytic subunit 57797 purE 4441676 purE Streptococcus pneumoniae D39 phosphoribosylaminoimidazole carboxylase catalytic subunit YP_815504.1 57309 D 373153 CDS YP_815506.1 116516392 4441599 57784..58875 1 NC_008533.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 58875 purK 4441599 purK Streptococcus pneumoniae D39 phosphoribosylaminoimidazole carboxylase ATPase subunit YP_815506.1 57784 D 373153 CDS YP_815508.1 116516948 4442025 58885..59112 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0055; equivalent gene in S.pneumoniae R6 = spr0055; hypothetical protein 59112 4442025 SPD_0061 Streptococcus pneumoniae D39 hypothetical protein YP_815508.1 58885 D 373153 CDS YP_815510.1 116516623 4442401 59175..60473 1 NC_008533.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 60473 purB 4442401 purB Streptococcus pneumoniae D39 adenylosuccinate lyase YP_815510.1 59175 D 373153 CDS YP_815512.1 116517042 4442356 complement(60528..64466) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0057; equivalent gene in S.pneumoniae R6 = spr0057; identified by match to protein family HMM PF00728; match to protein family HMM PF00746; match to protein family HMM PF04650; match to protein family HMM PF07501; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; beta-N-acetylhexosaminidase 64466 strH 4442356 strH Streptococcus pneumoniae D39 beta-N-acetylhexosaminidase YP_815512.1 60528 R 373153 CDS YP_815514.1 116515951 4441392 complement(64781..65524) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0058; equivalent gene in S.pneumoniae R6 = spr0058; identified by match to protein family HMM PF00392; match to protein family HMM PF07702; GntR family transcriptional regulator protein 65524 4441392 SPD_0064 Streptococcus pneumoniae D39 GntR family transcriptional regulator protein YP_815514.1 64781 R 373153 CDS YP_815516.1 116517213 4441811 65845..67632 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0060; equivalent gene in S.pneumoniae R6 = spr0059; identified by match to protein family HMM PF01301; match to protein family HMM PF02449; Beta-galactosidase 3 67632 bgaC 4441811 bgaC Streptococcus pneumoniae D39 Beta-galactosidase 3 YP_815516.1 65845 D 373153 CDS YP_815518.1 116516149 4442511 67629..68105 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0061; equivalent gene in S.pneumoniae R6 = spr0060; identified by match to protein family HMM PF03830; PTS system transporter subunit IIB 68105 4442511 SPD_0066 Streptococcus pneumoniae D39 PTS system transporter subunit IIB YP_815518.1 67629 D 373153 CDS YP_815520.1 116515606 4442745 68133..69038 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0062; equivalent gene in S.pneumoniae R6 = spr0061; identified by match to protein family HMM PF03609; PTS system transporter subunit IIC 69038 4442745 SPD_0067 Streptococcus pneumoniae D39 PTS system transporter subunit IIC YP_815520.1 68133 D 373153 CDS YP_815521.1 116515325 4442668 69025..69840 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0063; equivalent gene in S.pneumoniae R6 = spr0062; identified by match to protein family HMM PF03613; PTS system transporter subunit IID 69840 4442668 SPD_0068 Streptococcus pneumoniae D39 PTS system transporter subunit IID YP_815521.1 69025 D 373153 CDS YP_815523.1 116516395 4441602 69847..70251 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0064; equivalent gene in S.pneumoniae R6 = spr0063; identified by match to protein family HMM PF03610; PTS system transporter subunit IIA 70251 4441602 SPD_0069 Streptococcus pneumoniae D39 PTS system transporter subunit IIA YP_815523.1 69847 D 373153 CDS YP_815524.1 116515512 4442993 70550..71716 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0065; equivalent gene in S.pneumoniae R6 = spr0064; identified by match to protein family HMM PF01380; sugar isomerase 71716 agaS 4442993 agaS Streptococcus pneumoniae D39 sugar isomerase YP_815524.1 70550 D 373153 CDS YP_815527.1 116517175 4441851 71832..72869 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0066; equivalent gene in S.pneumoniae R6 = spr0065; identified by match to protein family HMM PF01263; aldose 1-epimerase 72869 galM 4441851 galM Streptococcus pneumoniae D39 aldose 1-epimerase YP_815527.1 71832 D 373153 CDS YP_815529.1 116517115 4441887 73076..73930 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0066; identified by match to protein family HMM PF00903; hypothetical protein 73930 4441887 SPD_0072 Streptococcus pneumoniae D39 hypothetical protein YP_815529.1 73076 D 373153 CDS YP_815531.1 116515835 4441126 74080..74337 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0067; identified by match to protein family HMM PF02583; hypothetical protein 74337 4441126 SPD_0073 Streptococcus pneumoniae D39 hypothetical protein YP_815531.1 74080 D 373153 CDS YP_815532.1 116516564 4441269 75312..76076 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0075; equivalent gene in S.pneumoniae R6 = spr0068; identified by match to protein family HMM PF01048; phosphorylase, Pnp/Udp family protein 76076 4441269 SPD_0074 Streptococcus pneumoniae D39 phosphorylase, Pnp/Udp family protein YP_815532.1 75312 D 373153 CDS YP_815535.1 116516250 4441760 76332..76517 1 NC_008533.1 hypothetical protein 76517 4441760 SPD_0075 Streptococcus pneumoniae D39 hypothetical protein YP_815535.1 76332 D 373153 CDS YP_815537.1 116516800 4442195 76686..78065 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0078; equivalent gene in S.pneumoniae R6 = spr0070; identified by match to protein family HMM PF02386; potassium uptake protein, Trk family protein 78065 4442195 SPD_0076 Streptococcus pneumoniae D39 potassium uptake protein, Trk family protein YP_815537.1 76686 D 373153 CDS YP_815540.1 116515848 4441539 78079..78744 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0079; equivalent gene in S.pneumoniae R6 = spr0071; identified by match to protein family HMM PF02254; potassium uptake protein, Trk family protein 78744 4441539 SPD_0077 Streptococcus pneumoniae D39 potassium uptake protein, Trk family protein YP_815540.1 78079 D 373153 CDS YP_815541.1 116517146 4441860 79054..79593 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0072; identified by match to protein family HMM PF00535; glycosyl transferase family protein 79593 4441860 SPD_0078 Streptococcus pneumoniae D39 glycosyl transferase family protein YP_815541.1 79054 D 373153 CDS YP_815545.1 116516097 4442691 79660..80070 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0074; hypothetical protein 80070 4442691 SPD_0079 Streptococcus pneumoniae D39 hypothetical protein YP_815545.1 79660 D 373153 CDS YP_815547.1 116515436 4441283 80186..83671 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0075; contains 6 repeats of 456-bp SSURE domain, exact sequence of repeats could not be determined. Placeholder sequence was inserted containing the 5 repeats used previously in spr0075 in the R6 genome sequence; identified by match to protein family HMM PF00746; match to protein family HMM PF04650; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; cell wall surface anchor family protein 83671 4441283 SPD_0080 Streptococcus pneumoniae D39 cell wall surface anchor family protein YP_815547.1 80186 D 373153 CDS YP_815548.1 116516719 4442307 83838..84536 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0083; equivalent gene in S.pneumoniae R6 = spr0076; identified by match to protein family HMM PF00072; match to protein family HMM PF00486; DNA-binding response regulator 84536 4442307 SPD_0081 Streptococcus pneumoniae D39 DNA-binding response regulator YP_815548.1 83838 D 373153 CDS YP_815550.1 116515418 4442488 84533..85585 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0084; equivalent gene in S.pneumoniae R6 = spr0077; identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; sensor histidine kinase 85585 4442488 SPD_0082 Streptococcus pneumoniae D39 sensor histidine kinase YP_815550.1 84533 D 373153 CDS YP_815552.1 116516581 4442104 85780..86391 1 NC_008533.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 86391 rpsD 4442104 rpsD Streptococcus pneumoniae D39 30S ribosomal protein S4 YP_815552.1 85780 D 373153 CDS YP_815554.1 116515746 4441035 86577..86735 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0086; equivalent gene in S.pneumoniae R6 = spr0014 In TIGR4 this gene is annotated as a truncation; however in R6 there are numerous near perfect copies as well as copies with a slightly longer version with a different end that is not present in either R6 or TIGR4 This indicates it may still function as a transposase.; IS630-Spn1, transposase Orf1 86735 4441035 SPD_0084 Streptococcus pneumoniae D39 IS630-Spn1, transposase Orf1 YP_815554.1 86577 D 373153 CDS YP_815557.1 116516364 4443026 complement(86833..86973) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0087; hypothetical protein 86973 4443026 SPD_0085 Streptococcus pneumoniae D39 hypothetical protein YP_815557.1 86833 R 373153 CDS YP_815560.1 116516484 4443013 87053..87313 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0088; equivalent gene in S.pneumoniae R6 = spr0080; hypothetical protein 87313 4443013 SPD_0086 Streptococcus pneumoniae D39 hypothetical protein YP_815560.1 87053 D 373153 CDS YP_815562.1 116516464 4442934 87267..87488 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0089; hypothetical protein 87488 4442934 SPD_0087 Streptococcus pneumoniae D39 hypothetical protein YP_815562.1 87267 D 373153 CDS YP_815564.1 116515415 4442485 87807..88736 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0090; equivalent gene in S.pneumoniae R6 = spr0081; identified by match to protein family HMM PF00528; ABC transporter permease 88736 4442485 SPD_0088 Streptococcus pneumoniae D39 ABC transporter permease YP_815564.1 87807 D 373153 CDS YP_815566.1 116516742 4442292 88750..89673 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0091; equivalent gene in S.pneumoniae R6 = spr0082; identified by match to protein family HMM PF00528; ABC transporter permease 89673 4442292 SPD_0089 Streptococcus pneumoniae D39 ABC transporter permease YP_815566.1 88750 D 373153 CDS YP_815568.1 116516928 4442042 89931..91406 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0092; equivalent gene in S.pneumoniae R6 = spr0083; identified by match to protein family HMM PF01547; ABC transporter substrate-binding protein 91406 4442042 SPD_0090 Streptococcus pneumoniae D39 ABC transporter substrate-binding protein YP_815568.1 89931 D 373153 CDS YP_815571.1 116517133 4442371 91678..92664 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0095; equivalent gene in S.pneumoniae R6 = spr0084; identified by match to protein family HMM PF00581; hypothetical protein 92664 4442371 SPD_0091 Streptococcus pneumoniae D39 hypothetical protein YP_815571.1 91678 D 373153 CDS YP_815572.1 116516138 4442500 92786..93646 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0096; equivalent gene in S.pneumoniae R6 = spr0085; hypothetical protein 93646 4442500 SPD_0092 Streptococcus pneumoniae D39 hypothetical protein YP_815572.1 92786 D 373153 CDS YP_815573.1 116516874 4442117 complement(93718..94782) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0097; equivalent gene in S.pneumoniae R6 = spr0086; hypothetical protein 94782 4442117 SPD_0093 Streptococcus pneumoniae D39 hypothetical protein YP_815573.1 93718 R 373153 CDS YP_815575.1 116515571 4442881 complement(94845..95756) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0098; equivalent gene in S.pneumoniae R6 = spr0087; hypothetical protein 95756 4442881 SPD_0094 Streptococcus pneumoniae D39 hypothetical protein YP_815575.1 94845 R 373153 CDS YP_815578.1 116516361 4442963 complement(95749..96342) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0099; equivalent gene in S.pneumoniae R6 = spr0088; hypothetical protein 96342 4442963 SPD_0095 Streptococcus pneumoniae D39 hypothetical protein YP_815578.1 95749 R 373153 CDS YP_815579.1 116515726 4442264 complement(96329..96655) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0100; equivalent gene in S.pneumoniae R6 = spr0089; identified by match to protein family HMM PF03551; hypothetical protein 96655 4442264 SPD_0096 Streptococcus pneumoniae D39 hypothetical protein YP_815579.1 96329 R 373153 CDS YP_815581.1 116515559 4442733 complement(96794..97960) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0101; equivalent gene in S.pneumoniae R6 = spr0090; identified by match to protein family HMM PF07690; transporter 97960 4442733 SPD_0097 Streptococcus pneumoniae D39 transporter YP_815581.1 96794 R 373153 CDS YP_815584.1 116516685 4441359 98018..99175 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0102; equivalent gene in S.pneumoniae R6 = spr0091; identified by match to protein family HMM PF00535; glycosyl transferase family protein 99175 4441359 SPD_0098 Streptococcus pneumoniae D39 glycosyl transferase family protein YP_815584.1 98018 D 373153 CDS YP_815587.1 116517199 4441836 99217..101067 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0103; equivalent gene in S.pneumoniae R6 = spr0092; identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF04321; match to protein family HMM PF07993; capsular polysaccharide biosynthesis protein 101067 capD 4441836 capD Streptococcus pneumoniae D39 capsular polysaccharide biosynthesis protein YP_815587.1 99217 D 373153 CDS YP_815590.1 116515790 4441555 complement(101463..102095) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0104; equivalent gene in S.pneumoniae R6 = spr0093; identified by match to protein family HMM PF00702; match to protein family HMM TIGR01549; hydrolase 102095 4441555 SPD_0101 Streptococcus pneumoniae D39 hydrolase YP_815590.1 101463 R 373153 CDS YP_815591.1 116516525 4443076 complement(102117..102989) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0105; equivalent gene in S.pneumoniae R6 = spr0094; identified by match to protein family HMM PF03313; match to protein family HMM TIGR00718; L-serine dehydratase, iron-sulfur-dependent subunit alpha 102989 sdhA 4443076 sdhA Streptococcus pneumoniae D39 L-serine dehydratase, iron-sulfur-dependent subunit alpha YP_815591.1 102117 R 373153 CDS YP_815593.1 116516124 4442212 complement(102998..103669) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0106; equivalent gene in S.pneumoniae R6 = spr0095; identified by match to protein family HMM PF01842; match to protein family HMM PF03315; match to protein family HMM TIGR00719; L-serine dehydratase, iron-sulfur-dependent subunit beta 103669 sdhB 4442212 sdhB Streptococcus pneumoniae D39 L-serine dehydratase, iron-sulfur-dependent subunit beta YP_815593.1 102998 R 373153 CDS YP_815595.1 116516732 4442321 103911..104414 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0107; equivalent gene in S.pneumoniae R6 = spr0096; identified by match to protein family HMM PF01476; LysM domain-containing protein 104414 4442321 SPD_0104 Streptococcus pneumoniae D39 LysM domain-containing protein YP_815595.1 103911 D 373153 CDS YP_815596.1 116515849 4441541 complement(104537..104785) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0114; equivalent gene in S.pneumoniae R6 = spr0097; hypothetical protein 104785 4441541 SPD_0105 Streptococcus pneumoniae D39 hypothetical protein YP_815596.1 104537 R 373153 CDS YP_815600.1 116517179 4441855 105242..105490 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0098; identified by match to protein family HMM TIGR01653; bacteriocin 105490 4441855 SPD_0106 Streptococcus pneumoniae D39 bacteriocin YP_815600.1 105242 D 373153 CDS YP_815603.1 116516371 4443033 105545..107653 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0110; equivalent gene in S.pneumoniae R6 = spr0099; identified by match to protein family HMM TIGR01654; membrnae protein 107653 4443033 SPD_0107 Streptococcus pneumoniae D39 membrnae protein YP_815603.1 105545 D 373153 CDS YP_815605.1 116516985 4442006 107650..108291 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0111; equivalent gene in S.pneumoniae R6 = spr0100; identified by match to protein family HMM PF00005; amino acid ABC transporter ATP-binding protein 108291 4442006 SPD_0108 Streptococcus pneumoniae D39 amino acid ABC transporter ATP-binding protein YP_815605.1 107650 D 373153 CDS YP_815607.1 116516177 4441134 108497..109303 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0112; equivalent gene in S.pneumoniae R6 = spr0101; identified by match to protein family HMM PF00497; amino acid ABC transporter periplasmic amino acid-binding protein 109303 4441134 SPD_0109 Streptococcus pneumoniae D39 amino acid ABC transporter periplasmic amino acid-binding protein YP_815607.1 108497 D 373153 CDS YP_815608.1 116515666 4441249 109320..110516 1 NC_008533.1 catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming; argininosuccinate synthase 110516 argG 4441249 argG Streptococcus pneumoniae D39 argininosuccinate synthase YP_815608.1 109320 D 373153 CDS YP_815610.1 116516947 4442024 110545..111936 1 NC_008533.1 catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 111936 argH 4442024 argH Streptococcus pneumoniae D39 argininosuccinate lyase YP_815610.1 110545 D 373153 CDS YP_815612.1 116515314 4442657 complement(112225..113088) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0108; equivalent gene in S.pneumoniae R6 = spr0104; identified by match to protein family HMM PF01381; hypothetical protein 113088 4442657 SPD_0112 Streptococcus pneumoniae D39 hypothetical protein YP_815612.1 112225 R 373153 CDS YP_815614.1 116516334 4442817 115766..116233 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0107; hypothetical protein 116233 4442817 SPD_0114 Streptococcus pneumoniae D39 hypothetical protein YP_815614.1 115766 D 373153 CDS YP_815617.1 116516521 4443072 116230..117582 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0108; hypothetical protein 117582 4443072 SPD_0115 Streptococcus pneumoniae D39 hypothetical protein YP_815617.1 116230 D 373153 CDS YP_815619.1 116515891 4441389 117728..118108 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0115; equivalent gene in S.pneumoniae R6 = spr0109; hypothetical protein 118108 4441389 SPD_0116 Streptococcus pneumoniae D39 hypothetical protein YP_815619.1 117728 D 373153 CDS YP_815621.1 116516318 4442801 119688..120059 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0111; hypothetical protein 120059 4442801 SPD_0117 Streptococcus pneumoniae D39 hypothetical protein YP_815621.1 119688 D 373153 CDS YP_815623.1 116515720 4442258 120653..120778 1 NC_008533.1 hypothetical protein 120778 4442258 SPD_0118 Streptococcus pneumoniae D39 hypothetical protein YP_815623.1 120653 D 373153 CDS YP_815626.1 116515480 4442650 121084..122142 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0113; hypothetical protein 122142 4442650 SPD_0119 Streptococcus pneumoniae D39 hypothetical protein YP_815626.1 121084 D 373153 CDS YP_815628.1 116515901 4442781 122456..123433 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0114; hypothetical protein 123433 4442781 SPD_0120 Streptococcus pneumoniae D39 hypothetical protein YP_815628.1 122456 D 373153 CDS YP_815630.1 116516556 4441261 123810..124184 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0115; hypothetical protein 124184 4441261 SPD_0121 Streptococcus pneumoniae D39 hypothetical protein YP_815630.1 123810 D 373153 CDS YP_815632.1 116515445 4441292 124392..125294 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0117; hypothetical protein 125294 4441292 SPD_0122 Streptococcus pneumoniae D39 hypothetical protein YP_815632.1 124392 D 373153 CDS YP_815634.1 116516169 4442843 125350..125703 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0118; hypothetical protein 125703 4442843 SPD_0123 Streptococcus pneumoniae D39 hypothetical protein YP_815634.1 125350 D 373153 CDS YP_815636.1 116516163 4442837 125670..126428 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0119; hypothetical protein 126428 4442837 SPD_0124 Streptococcus pneumoniae D39 hypothetical protein YP_815636.1 125670 D 373153 CDS YP_815639.1 116516979 4441999 127557..127802 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0116; equivalent gene in S.pneumoniae R6 = spr0120; hypothetical protein 127802 4441999 SPD_0125 Streptococcus pneumoniae D39 hypothetical protein YP_815639.1 127557 D 373153 CDS YP_815641.1 116515876 4441373 128356..130215 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0121; identified by match to protein family HMM PF01473; surface protein A 130215 pspA 4441373 pspA Streptococcus pneumoniae D39 surface protein A YP_815641.1 128356 D 373153 CDS YP_815643.1 116516757 4442268 130616..131737 1 NC_008533.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 131737 mnmA 4442268 mnmA Streptococcus pneumoniae D39 tRNA-specific 2-thiouridylase MnmA YP_815643.1 130616 D 373153 CDS YP_815645.1 116516444 4442563 131878..132333 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0119; equivalent gene in S.pneumoniae R6 = spr0123; identified by match to protein family HMM PF00293; MutT/nudix family protein 132333 4442563 SPD_0128 Streptococcus pneumoniae D39 MutT/nudix family protein YP_815645.1 131878 D 373153 CDS YP_815647.1 116515312 4441194 132343..134256 1 NC_008533.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification protein GidA 134256 gidA 4441194 gidA Streptococcus pneumoniae D39 tRNA uridine 5-carboxymethylaminomethyl modification protein GidA YP_815647.1 132343 D 373153 CDS YP_815649.1 116516160 4442834 complement(134636..136315) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0121; equivalent gene in S.pneumoniae R6 = spr0125; identified by match to protein family HMM PF00753; match to protein family HMM PF07521; match to protein family HMM TIGR00649; metallo-beta-lactamase domain-containing protein 136315 4442834 SPD_0130 Streptococcus pneumoniae D39 metallo-beta-lactamase domain-containing protein YP_815649.1 134636 R 373153 CDS YP_815651.1 116515572 4442882 complement(136317..136550) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0122; equivalent gene in S.pneumoniae R6 = spr0126; identified by match to protein family HMM PF07288; hypothetical protein 136550 4442882 SPD_0131 Streptococcus pneumoniae D39 hypothetical protein YP_815651.1 136317 R 373153 CDS YP_815652.1 116516595 4441224 complement(137368..137520) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0124; equivalent gene in S.pneumoniae R6 = spr0127; identified by match to protein family HMM TIGR01847; hypothetical protein 137520 4441224 SPD_0132 Streptococcus pneumoniae D39 hypothetical protein YP_815652.1 137368 R 373153 CDS YP_815653.1 116516791 4442244 complement(137522..137707) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0125; equivalent gene in S.pneumoniae R6 = spr0128; hypothetical protein 137707 4442244 SPD_0133 Streptococcus pneumoniae D39 hypothetical protein YP_815653.1 137522 R 373153 CDS YP_815654.1 116516776 4442229 137885..138568 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0127; equivalent gene in S.pneumoniae R6 = spr0129; identified by match to protein family HMM PF00814; hypothetical protein 138568 4442229 SPD_0134 Streptococcus pneumoniae D39 hypothetical protein YP_815654.1 137885 D 373153 CDS YP_815655.1 116516175 4441132 138565..139002 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0128; equivalent gene in S.pneumoniae R6 = spr0130; identified by match to protein family HMM PF00583; match to protein family HMM TIGR01575; ribosomal-protein-alanine acetyltransferase 139002 rimI 4441132 rimI Streptococcus pneumoniae D39 ribosomal-protein-alanine acetyltransferase YP_815655.1 138565 D 373153 CDS YP_815656.1 116517063 4441951 138992..140002 1 NC_008533.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; DNA-binding/iron metalloprotein/AP endonuclease 140002 4441951 SPD_0136 Streptococcus pneumoniae D39 DNA-binding/iron metalloprotein/AP endonuclease YP_815656.1 138992 D 373153 CDS YP_815657.1 116516328 4442811 142604..143809 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0133; equivalent gene in S.pneumoniae R6 = spr0135; identified by match to protein family HMM PF00534; glycoside hydrolase family protein 143809 4442811 SPD_0138 Streptococcus pneumoniae D39 glycoside hydrolase family protein YP_815657.1 142604 D 373153 CDS YP_815658.1 116516905 4442091 143802..144755 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0136; equivalent gene in S.pneumoniae R6 = spr0136; identified by match to protein family HMM PF00535; glycosyl transferase family protein 144755 4442091 SPD_0139 Streptococcus pneumoniae D39 glycosyl transferase family protein YP_815658.1 143802 D 373153 CDS YP_815659.1 116516697 4441371 144765..146381 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0137; equivalent gene in S.pneumoniae R6 = spr0137; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 146381 4441371 SPD_0140 Streptococcus pneumoniae D39 ABC transporter ATP-binding protein YP_815659.1 144765 D 373153 CDS YP_815660.1 116515417 4442487 146691..147158 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0138; hypothetical protein 147158 4442487 SPD_0141 Streptococcus pneumoniae D39 hypothetical protein YP_815660.1 146691 D 373153 CDS YP_815661.1 116516472 4442942 147164..147919 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0139; equivalent gene in S.pneumoniae R6 = spr0138; identified by match to protein family HMM PF02585; hypothetical protein 147919 4442942 SPD_0142 Streptococcus pneumoniae D39 hypothetical protein YP_815661.1 147164 D 373153 CDS YP_815662.1 116515340 4441082 147932..149104 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0139; identified by match to protein family HMM PF00984; match to protein family HMM PF03721; UDP-glucose 6-dehydrogenase 149104 4441082 SPD_0143 Streptococcus pneumoniae D39 UDP-glucose 6-dehydrogenase YP_815662.1 147932 D 373153 CDS YP_815663.1 116516617 4442395 149499..150362 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0141; equivalent gene in S.pneumoniae R6 = spr0140; identified by match to protein family HMM TIGR01716; transcriptional regulator 150362 4442395 SPD_0144 Streptococcus pneumoniae D39 transcriptional regulator YP_815663.1 149499 D 373153 CDS YP_815664.1 116516089 4442683 150653..150886 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0142; equivalent gene in S.pneumoniae R6 = spr0141; hypothetical protein 150886 4442683 SPD_0145 Streptococcus pneumoniae D39 hypothetical protein YP_815664.1 150653 D 373153 CDS YP_815665.1 116516352 4442954 150908..151585 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0143; equivalent gene in S.pneumoniae R6 = spr0142; identified by match to protein family HMM PF02517; CAAX amino terminal protease family protein 151585 4442954 SPD_0146 Streptococcus pneumoniae D39 CAAX amino terminal protease family protein YP_815665.1 150908 D 373153 CDS YP_815666.1 116515826 4441117 151597..152262 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0144; equivalent gene in S.pneumoniae R6 = spr0143; identified by match to protein family HMM PF02517; CAAX amino terminal protease family protein 152262 4441117 SPD_0147 Streptococcus pneumoniae D39 CAAX amino terminal protease family protein YP_815666.1 151597 D 373153 CDS YP_815667.1 116517061 4441949 152334..153560 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0145; equivalent gene in S.pneumoniae R6 = spr0144; identified by match to protein family HMM PF07690; transporter major facilitator family protein 153560 4441949 SPD_0148 Streptococcus pneumoniae D39 transporter major facilitator family protein YP_815667.1 152334 D 373153 CDS YP_815668.1 116516566 4441271 153893..154366 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0146; equivalent gene in S.pneumoniae R6 = spr0145; identified by match to protein family HMM PF03591; hypothetical protein 154366 4441271 SPD_0149 Streptococcus pneumoniae D39 hypothetical protein YP_815668.1 153893 D 373153 CDS YP_815669.1 116517098 4441909 154470..155300 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0148; equivalent gene in S.pneumoniae R6 = spr0146; identified by match to protein family HMM PF00497; ABC transporter substrate-binding protein 155300 4441909 SPD_0150 Streptococcus pneumoniae D39 ABC transporter substrate-binding protein YP_815669.1 154470 D 373153 CDS YP_815670.1 116516447 4442566 155454..156308 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0149; equivalent gene in S.pneumoniae R6 = spr0147; identified by match to protein family HMM PF03180; lipoprotein 156308 4442566 SPD_0151 Streptococcus pneumoniae D39 lipoprotein YP_815670.1 155454 D 373153 CDS YP_815671.1 116515387 4441623 156408..157781 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0150; equivalent gene in S.pneumoniae R6 = spr0148; identified by match to protein family HMM PF01546; match to protein family HMM PF07687; hypothetical protein 157781 4441623 SPD_0152 Streptococcus pneumoniae D39 hypothetical protein YP_815671.1 156408 D 373153 CDS YP_815672.1 116515828 4441119 157774..158835 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0151; equivalent gene in S.pneumoniae R6 = spr0149; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 158835 4441119 SPD_0153 Streptococcus pneumoniae D39 ABC transporter ATP-binding protein YP_815672.1 157774 D 373153 CDS YP_815673.1 116517111 4441883 158837..159529 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0152; equivalent gene in S.pneumoniae R6 = spr0150; identified by match to protein family HMM PF00528; ABC transporter permease 159529 4441883 SPD_0154 Streptococcus pneumoniae D39 ABC transporter permease YP_815673.1 158837 D 373153 CDS YP_815674.1 116516723 4442311 complement(159559..160128) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0153; equivalent gene in S.pneumoniae R6 = spr0151; identified by match to protein family HMM TIGR02185; hypothetical protein 160128 4442311 SPD_0155 Streptococcus pneumoniae D39 hypothetical protein YP_815674.1 159559 R 373153 CDS YP_815675.1 116515665 4441248 160263..160877 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0154; equivalent gene in S.pneumoniae R6 = spr0152; identified by match to protein family HMM PF04854; hypothetical protein 160877 4441248 SPD_0156 Streptococcus pneumoniae D39 hypothetical protein YP_815675.1 160263 D 373153 CDS YP_815676.1 116515317 4442660 160879..162525 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0155; equivalent gene in S.pneumoniae R6 = spr0153; identified by match to protein family HMM PF00672; match to protein family HMM PF02518; match to protein family HMM PF06580; sensor histidine kinase 162525 4442660 SPD_0157 Streptococcus pneumoniae D39 sensor histidine kinase YP_815676.1 160879 D 373153 CDS YP_815677.1 116516660 4443064 162537..163823 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0156; equivalent gene in S.pneumoniae R6 = spr0154; identified by match to protein family HMM PF00072; match to protein family HMM PF00165; DNA-binding response regulator 163823 4443064 SPD_0158 Streptococcus pneumoniae D39 DNA-binding response regulator YP_815677.1 162537 D 373153 CDS YP_815678.1 116516260 4441770 163875..164408 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0157; equivalent gene in S.pneumoniae R6 = spr0155; hypothetical protein 164408 4441770 SPD_0159 Streptococcus pneumoniae D39 hypothetical protein YP_815678.1 163875 D 373153 CDS YP_815679.1 116516077 4442534 164486..164956 1 NC_008533.1 has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; flavoprotein NrdI 164956 4442534 SPD_0160 Streptococcus pneumoniae D39 flavoprotein NrdI YP_815679.1 164486 D 373153 CDS YP_815680.1 116516889 4442074 complement(165249..166511) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0159; equivalent gene in S.pneumoniae R6 = spr0157; hypothetical protein 166511 4442074 SPD_0161 Streptococcus pneumoniae D39 hypothetical protein YP_815680.1 165249 R 373153 CDS YP_815681.1 116515862 4441098 complement(166821..167279) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0160; equivalent gene in S.pneumoniae R6 = spr0158; hypothetical protein 167279 4441098 SPD_0162 Streptococcus pneumoniae D39 hypothetical protein YP_815681.1 166821 R 373153 CDS YP_815682.1 116516702 4442328 complement(167276..167716) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0161; equivalent gene in S.pneumoniae R6 = spr0159; identified by match to protein family HMM PF04397; hypothetical protein 167716 4442328 SPD_0163 Streptococcus pneumoniae D39 hypothetical protein YP_815682.1 167276 R 373153 CDS YP_815683.1 116515582 4441201 167832..168011 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0172; hypothetical protein 168011 4441201 SPD_0164 Streptococcus pneumoniae D39 hypothetical protein YP_815683.1 167832 D 373153 CDS YP_815684.1 116516396 4441603 168072..170021 1 NC_008533.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein 170021 mutL 4441603 mutL Streptococcus pneumoniae D39 DNA mismatch repair protein YP_815684.1 168072 D 373153 CDS YP_815685.1 116517138 4442376 complement(170346..170813) 1 NC_008533.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase 170813 ribH 4442376 ribH Streptococcus pneumoniae D39 6,7-dimethyl-8-ribityllumazine synthase YP_815685.1 170346 R 373153 CDS YP_815686.1 116516104 4441629 complement(170814..172019) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0176; equivalent gene in S.pneumoniae R6 = spr0162; identified by match to protein family HMM PF00925; match to protein family HMM PF00926; match to protein family HMM TIGR00505; match to protein family HMM TIGR00506; 3,4-dihydroxy-2-butanone 4-phosphate synthase 172019 ribB 4441629 ribB Streptococcus pneumoniae D39 3,4-dihydroxy-2-butanone 4-phosphate synthase YP_815686.1 170814 R 373153 CDS YP_815687.1 116516797 4442192 complement(172039..172674) 1 NC_008533.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha 172674 ribE 4442192 ribE Streptococcus pneumoniae D39 riboflavin synthase subunit alpha YP_815687.1 172039 R 373153 CDS YP_815688.1 116515773 4441673 complement(172659..173759) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0178; equivalent gene in S.pneumoniae R6 = spr0164; identified by match to protein family HMM PF00383; match to protein family HMM PF01872; match to protein family HMM TIGR00227; match to protein family HMM TIGR00326; riboflavin biosynthesis protein RibD 173759 ribD 4441673 ribD Streptococcus pneumoniae D39 riboflavin biosynthesis protein RibD YP_815688.1 172659 R 373153 CDS YP_815689.1 116515482 4442652 174163..174756 1 NC_008533.1 plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 174756 ruvA 4442652 ruvA Streptococcus pneumoniae D39 Holliday junction DNA helicase RuvA YP_815689.1 174163 D 373153 CDS YP_815690.1 116516468 4442938 174766..175329 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0180; equivalent gene in S.pneumoniae R6 = spr0166; identified by match to protein family HMM PF03352; DNA-3-methyladenine glycosylase I 175329 tag 4442938 tag Streptococcus pneumoniae D39 DNA-3-methyladenine glycosylase I YP_815690.1 174766 D 373153 CDS YP_815691.1 116515703 4441445 175326..176003 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0181; equivalent gene in S.pneumoniae R6 = spr0167; identified by match to protein family HMM PF02517; hypothetical protein 176003 4441445 SPD_0172 Streptococcus pneumoniae D39 hypothetical protein YP_815691.1 175326 D 373153 CDS YP_815692.1 116516516 4443067 complement(176158..177189) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0182; equivalent gene in S.pneumoniae R6 = spr0168; identified by match to protein family HMM PF02016; MccC family protein 177189 4443067 SPD_0173 Streptococcus pneumoniae D39 MccC family protein YP_815692.1 176158 R 373153 CDS YP_815693.1 116516921 4442070 complement(177444..178148) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0184; equivalent gene in S.pneumoniae R6 = spr0169; identified by match to protein family HMM PF06570; hypothetical protein 178148 4442070 SPD_0174 Streptococcus pneumoniae D39 hypothetical protein YP_815693.1 177444 R 373153 CDS YP_815694.1 116515813 4442860 complement(178139..179083) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0185; equivalent gene in S.pneumoniae R6 = spr0170; identified by match to protein family HMM PF01544; magnesium transporter CorA family protein 179083 4442860 SPD_0175 Streptococcus pneumoniae D39 magnesium transporter CorA family protein YP_815694.1 178139 R 373153 CDS YP_815695.1 116517125 4441897 179215..182046 1 NC_008533.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 182046 uvrA 4441897 uvrA Streptococcus pneumoniae D39 excinuclease ABC subunit A YP_815695.1 179215 D 373153 CDS YP_815696.1 116516135 4442225 182039..183100 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0187; equivalent gene in S.pneumoniae R6 = spr0172; identified by match to protein family HMM PF00557; peptidase M24 family protein 183100 4442225 SPD_0177 Streptococcus pneumoniae D39 peptidase M24 family protein YP_815696.1 182039 D 373153 CDS YP_815697.1 116516433 4441659 183232..183630 1 NC_008533.1 the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress; transcriptional regulator Spx 183630 spxA 4441659 spxA Streptococcus pneumoniae D39 transcriptional regulator Spx YP_815697.1 183232 D 373153 CDS YP_815698.1 116515403 4442473 183696..184265 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0191; equivalent gene in S.pneumoniae R6 = spr0174; hypothetical protein 184265 4442473 SPD_0179 Streptococcus pneumoniae D39 hypothetical protein YP_815698.1 183696 D 373153 CDS YP_815699.1 116516360 4442962 184352..184618 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0192; equivalent gene in S.pneumoniae R6 = spr0175; identified by match to protein family HMM PF06135; hypothetical protein 184618 4442962 SPD_0180 Streptococcus pneumoniae D39 hypothetical protein YP_815699.1 184352 D 373153 CDS YP_815700.1 116515819 4442867 184622..185041 1 NC_008533.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 185041 4442867 SPD_0181 Streptococcus pneumoniae D39 Holliday junction resolvase-like protein YP_815700.1 184622 D 373153 CDS YP_815701.1 116516683 4441357 185057..185362 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0194; equivalent gene in S.pneumoniae R6 = spr0177; identified by match to protein family HMM PF06949; hypothetical protein 185362 4441357 SPD_0182 Streptococcus pneumoniae D39 hypothetical protein YP_815701.1 185057 D 373153 CDS YP_815702.1 116516494 4443024 185813..187069 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0197; equivalent gene in S.pneumoniae R6 = spr0178; identified by match to protein family HMM PF02875; match to protein family HMM TIGR01499; folylpolyglutamate synthase 187069 folC 4443024 folC Streptococcus pneumoniae D39 folylpolyglutamate synthase YP_815702.1 185813 D 373153 CDS YP_815703.1 116515524 4443005 187153..187584 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0179; hypothetical protein 187584 4443005 SPD_0184 Streptococcus pneumoniae D39 hypothetical protein YP_815703.1 187153 D 373153 CDS YP_815704.1 116516680 4441354 187730..189262 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0199; equivalent gene in S.pneumoniae R6 = spr0180; identified by match to protein family HMM PF00614; cardiolipin synthetase 189262 4441354 SPD_0185 Streptococcus pneumoniae D39 cardiolipin synthetase YP_815704.1 187730 D 373153 CDS YP_815705.1 116515592 4441212 189520..191058 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0200; equivalent gene in S.pneumoniae R6 = spr0182; competence-induced protein Ccs4 191058 4441212 SPD_0186 Streptococcus pneumoniae D39 competence-induced protein Ccs4 YP_815705.1 189520 D 373153 CDS YP_815706.1 116516887 4442072 191178..193385 1 NC_008533.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; anaerobic ribonucleoside triphosphate reductase 193385 nrdD 4442072 nrdD Streptococcus pneumoniae D39 anaerobic ribonucleoside triphosphate reductase YP_815706.1 191178 D 373153 CDS YP_815707.1 116515859 4441095 193397..193537 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0203; hypothetical protein 193537 4441095 SPD_0188 Streptococcus pneumoniae D39 hypothetical protein YP_815707.1 193397 D 373153 CDS YP_815708.1 116517222 4441790 193581..194087 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0204; equivalent gene in S.pneumoniae R6 = spr0184; identified by match to protein family HMM PF00583; GNAT family acetyltransferase 194087 4441790 SPD_0189 Streptococcus pneumoniae D39 GNAT family acetyltransferase YP_815708.1 193581 D 373153 CDS YP_815709.1 116516445 4442564 194080..194670 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0205; equivalent gene in S.pneumoniae R6 = spr0185; identified by match to protein family HMM PF04055; match to protein family HMM TIGR02491; anaerobic ribonucleoside-triphosphate reductase activating protein 194670 nrdG 4442564 nrdG Streptococcus pneumoniae D39 anaerobic ribonucleoside-triphosphate reductase activating protein YP_815709.1 194080 D 373153 CDS YP_815710.1 116516988 4442009 194667..195284 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0207; equivalent gene in S.pneumoniae R6 = spr0186; identified by match to protein family HMM PF00485; hypothetical protein 195284 4442009 SPD_0191 Streptococcus pneumoniae D39 hypothetical protein YP_815710.1 194667 D 373153 CDS YP_815711.1 116516663 4442442 195551..195859 1 NC_008533.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 195859 rpsJ 4442442 rpsJ Streptococcus pneumoniae D39 30S ribosomal protein S10 YP_815711.1 195551 D 373153 CDS YP_815712.1 116516725 4442313 196076..196702 1 NC_008533.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 196702 rplC 4442313 rplC Streptococcus pneumoniae D39 50S ribosomal protein L3 YP_815712.1 196076 D 373153 CDS YP_815713.1 116515366 4441166 196727..197350 1 NC_008533.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 197350 rplD 4441166 rplD Streptococcus pneumoniae D39 50S ribosomal protein L4 YP_815713.1 196727 D 373153 CDS YP_815714.1 116515830 4441121 197350..197646 1 NC_008533.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 197646 rplW 4441121 rplW Streptococcus pneumoniae D39 50S ribosomal protein L23 YP_815714.1 197350 D 373153 CDS YP_815715.1 116515638 4441318 197664..198497 1 NC_008533.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 198497 rplB 4441318 rplB Streptococcus pneumoniae D39 50S ribosomal protein L2 YP_815715.1 197664 D 373153 CDS YP_815716.1 116516112 4441637 198601..198882 1 NC_008533.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 198882 rpsS 4441637 rpsS Streptococcus pneumoniae D39 30S ribosomal protein S19 YP_815716.1 198601 D 373153 CDS YP_815717.1 116517196 4441833 198894..199238 1 NC_008533.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 199238 rplV 4441833 rplV Streptococcus pneumoniae D39 50S ribosomal protein L22 YP_815717.1 198894 D 373153 CDS YP_815718.1 116515402 4442472 199251..199904 1 NC_008533.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 199904 rpsC 4442472 rpsC Streptococcus pneumoniae D39 30S ribosomal protein S3 YP_815718.1 199251 D 373153 CDS YP_815719.1 116515627 4442707 199908..200321 1 NC_008533.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 200321 rplP 4442707 rplP Streptococcus pneumoniae D39 50S ribosomal protein L16 YP_815719.1 199908 D 373153 CDS YP_815720.1 116516938 4442014 200331..200537 1 NC_008533.1 one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 200537 rpmC 4442014 rpmC Streptococcus pneumoniae D39 50S ribosomal protein L29 YP_815720.1 200331 D 373153 CDS YP_815721.1 116515855 4441547 200562..200822 1 NC_008533.1 primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 200822 rpsQ 4441547 rpsQ Streptococcus pneumoniae D39 30S ribosomal protein S17 YP_815721.1 200562 D 373153 CDS YP_815722.1 116517026 4441971 200848..201216 1 NC_008533.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 201216 rplN 4441971 rplN Streptococcus pneumoniae D39 50S ribosomal protein L14 YP_815722.1 200848 D 373153 CDS YP_815723.1 116516050 4442759 201294..201599 1 NC_008533.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 201599 rplX 4442759 rplX Streptococcus pneumoniae D39 50S ribosomal protein L24 YP_815723.1 201294 D 373153 CDS YP_815724.1 116515434 4441281 201623..202165 1 NC_008533.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 202165 rplE 4441281 rplE Streptococcus pneumoniae D39 50S ribosomal protein L5 YP_815724.1 201623 D 373153 CDS YP_815725.1 116516311 4442794 202183..202452 1 NC_008533.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 202452 rpsN 4442794 rpsN Streptococcus pneumoniae D39 30S ribosomal protein S14 YP_815725.1 202183 D 373153 CDS YP_815726.1 116515705 4441447 202737..203135 1 NC_008533.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 203135 rpsH 4441447 rpsH Streptococcus pneumoniae D39 30S ribosomal protein S8 YP_815726.1 202737 D 373153 CDS YP_815727.1 116516940 4442016 203327..203863 1 NC_008533.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 203863 rplF 4442016 rplF Streptococcus pneumoniae D39 50S ribosomal protein L6 YP_815727.1 203327 D 373153 CDS YP_815728.1 116515871 4441109 203947..204303 1 NC_008533.1 binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 204303 rplR 4441109 rplR Streptococcus pneumoniae D39 50S ribosomal protein L18 YP_815728.1 203947 D 373153 CDS YP_815729.1 116515495 4441305 204321..204815 1 NC_008533.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 204815 rpsE 4441305 rpsE Streptococcus pneumoniae D39 30S ribosomal protein S5 YP_815729.1 204321 D 373153 CDS YP_815730.1 116516736 4442286 204829..205011 1 NC_008533.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 205011 rpmD 4442286 rpmD Streptococcus pneumoniae D39 50S ribosomal protein L30 YP_815730.1 204829 D 373153 CDS YP_815731.1 116515385 4441621 205156..205596 1 NC_008533.1 late assembly protein; 50S ribosomal protein L15 205596 rplO 4441621 rplO Streptococcus pneumoniae D39 50S ribosomal protein L15 YP_815731.1 205156 D 373153 CDS YP_815732.1 116516915 4442064 205609..206919 1 NC_008533.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 206919 secY 4442064 secY Streptococcus pneumoniae D39 preprotein translocase subunit SecY YP_815732.1 205609 D 373153 CDS YP_815733.1 116515877 4441374 207070..207708 1 NC_008533.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 207708 adk 4441374 adk Streptococcus pneumoniae D39 adenylate kinase YP_815733.1 207070 D 373153 CDS YP_815734.1 116517117 4441889 207825..208043 1 NC_008533.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 208043 infA 4441889 infA Streptococcus pneumoniae D39 translation initiation factor IF-1 YP_815734.1 207825 D 373153 CDS YP_815735.1 116516047 4442756 208202..208567 1 NC_008533.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 208567 rpsM 4442756 rpsM Streptococcus pneumoniae D39 30S ribosomal protein S13 YP_815735.1 208202 D 373153 CDS YP_815736.1 116515441 4441288 208585..208968 1 NC_008533.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 208968 rpsK 4441288 rpsK Streptococcus pneumoniae D39 30S ribosomal protein S11 YP_815736.1 208585 D 373153 CDS YP_815737.1 116516293 4442582 209011..209946 1 NC_008533.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 209946 rpoA 4442582 rpoA Streptococcus pneumoniae D39 DNA-directed RNA polymerase subunit alpha YP_815737.1 209011 D 373153 CDS YP_815738.1 116515447 4441294 209958..210344 1 NC_008533.1 is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 210344 rplQ 4441294 rplQ Streptococcus pneumoniae D39 50S ribosomal protein L17 YP_815738.1 209958 D 373153 CDS YP_815739.1 116516644 4443048 210609..210875 1 NC_008533.1 ACT domain-containing protein; hypothetical protein 210875 4443048 SPD_0220 Streptococcus pneumoniae D39 hypothetical protein YP_815739.1 210609 D 373153 CDS YP_815740.1 116516487 4443016 212467..213159 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0240; equivalent gene in S.pneumoniae R6 = spr0219; identified by match to protein family HMM PF00300; phosphoglycerate mutase family protein 213159 4443016 SPD_0222 Streptococcus pneumoniae D39 phosphoglycerate mutase family protein YP_815740.1 212467 D 373153 CDS YP_815741.1 116515628 4442708 complement(213262..214254) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0220; identified by match to protein family HMM PF00528; iron(III) ABC transporter permease 214254 4442708 SPD_0223 Streptococcus pneumoniae D39 iron(III) ABC transporter permease YP_815741.1 213262 R 373153 CDS YP_815742.1 116516726 4442315 complement(214281..214907) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0221; iron(III) ABC transporter permease 214907 4442315 SPD_0224 Streptococcus pneumoniae D39 iron(III) ABC transporter permease YP_815742.1 214281 R 373153 CDS YP_815743.1 116516814 4442171 complement(214897..215988) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0242; equivalent gene in S.pneumoniae R6 = spr0222; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 215988 4442171 SPD_0225 Streptococcus pneumoniae D39 ABC transporter ATP-binding protein YP_815743.1 214897 R 373153 CDS YP_815744.1 116515816 4442863 complement(216001..216369) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0243; equivalent gene in S.pneumoniae R6 = spr0223; iron ABC transporter iron-binding protein 216369 4442863 SPD_0226 Streptococcus pneumoniae D39 iron ABC transporter iron-binding protein YP_815744.1 216001 R 373153 CDS YP_815745.1 116516973 4442926 complement(216514..216708) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0243; equivalent gene in S.pneumoniae R6 = spr0224; iron(III) ABC transporter iron-binding protein 216708 4442926 SPD_0227 Streptococcus pneumoniae D39 iron(III) ABC transporter iron-binding protein YP_815745.1 216514 R 373153 CDS YP_815746.1 116516144 4442506 complement(217340..217537) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0225; identified by match to protein family HMM PF00165; AraC family transcriptional regulator 217537 4442506 SPD_0228 Streptococcus pneumoniae D39 AraC family transcriptional regulator YP_815746.1 217340 R 373153 CDS YP_815747.1 116517186 4441823 complement(217612..218388) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0245; equivalent gene in S.pneumoniae R6 = spr0226; identified by match to protein family HMM PF04055; match to protein family HMM TIGR02494; glycyl-radical enzyme activating protein family protein 218388 4441823 SPD_0229 Streptococcus pneumoniae D39 glycyl-radical enzyme activating protein family protein YP_815747.1 217612 R 373153 CDS YP_815748.1 116516292 4442581 218510..219256 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0246; equivalent gene in S.pneumoniae R6 = spr0227; identified by match to protein family HMM PF00455; match to protein family HMM PF08220; DeoR family transcriptional regulator 219256 4442581 SPD_0230 Streptococcus pneumoniae D39 DeoR family transcriptional regulator YP_815748.1 218510 D 373153 CDS YP_815749.1 116517202 4441800 219269..220249 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0247; equivalent gene in S.pneumoniae R6 = spr0228; identified by match to protein family HMM PF04198; transcriptional activator 220249 4441800 SPD_0231 Streptococcus pneumoniae D39 transcriptional activator YP_815749.1 219269 D 373153 CDS YP_815750.1 116516692 4441366 220444..220764 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0248; equivalent gene in S.pneumoniae R6 = spr0229; identified by match to protein family HMM PF02255; PTS system transporter subunit IIA 220764 4441366 SPD_0232 Streptococcus pneumoniae D39 PTS system transporter subunit IIA YP_815750.1 220444 D 373153 CDS YP_815751.1 116515458 4441183 220810..221118 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0249; equivalent gene in S.pneumoniae R6 = spr0230; identified by match to protein family HMM PF02302; PTS system transporter subunit IIB 221118 4441183 SPD_0233 Streptococcus pneumoniae D39 PTS system transporter subunit IIB YP_815751.1 220810 D 373153 CDS YP_815752.1 116516696 4441370 221135..222433 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0250; equivalent gene in S.pneumoniae R6 = spr0231; identified by match to protein family HMM PF02378; match to protein family HMM TIGR00410; PTS system transporter subunit IIC 222433 4441370 SPD_0234 Streptococcus pneumoniae D39 PTS system transporter subunit IIC YP_815752.1 221135 D 373153 CDS YP_815753.1 116515577 4442887 222584..225022 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0251; equivalent gene in S.pneumoniae R6 = spr0232; identified by match to protein family HMM PF01228; match to protein family HMM PF02901; match to protein family HMM TIGR01774; pyruvate formate-lyase 225022 pfl 4442887 pfl Streptococcus pneumoniae D39 pyruvate formate-lyase YP_815753.1 222584 D 373153 CDS YP_815754.1 116516937 4442052 225041..225709 1 NC_008533.1 similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase 225709 talC 4442052 talC Streptococcus pneumoniae D39 fructose-6-phosphate aldolase YP_815754.1 225041 D 373153 CDS YP_815755.1 116515896 4442775 225727..226815 1 NC_008533.1 forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone; glycerol dehydrogenase 226815 gldA 4442775 gldA Streptococcus pneumoniae D39 glycerol dehydrogenase YP_815755.1 225727 D 373153 CDS YP_815756.1 116517205 4441803 227270..229771 1 NC_008533.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 229771 leuS 4441803 leuS Streptococcus pneumoniae D39 leucyl-tRNA synthetase YP_815756.1 227270 D 373153 CDS YP_815757.1 116515892 4441390 229965..230660 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0255; equivalent gene in S.pneumoniae R6 = spr0236; identified by match to protein family HMM PF00583; GNAT family acetyltransferase 230660 4441390 SPD_0239 Streptococcus pneumoniae D39 GNAT family acetyltransferase YP_815757.1 229965 D 373153 CDS YP_815758.1 116517164 4441839 230672..231088 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0237; identified by match to protein family HMM PF00583; GNAT family acetyltransferase 231088 4441839 SPD_0240 Streptococcus pneumoniae D39 GNAT family acetyltransferase YP_815758.1 230672 D 373153 CDS YP_815759.1 116515806 4442853 232129..233127 1 NC_008533.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 233127 ruvB 4442853 ruvB Streptococcus pneumoniae D39 Holliday junction DNA helicase RuvB YP_815759.1 232129 D 373153 CDS YP_815760.1 116516380 4443043 233108..233680 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0260; equivalent gene in S.pneumoniae R6 = spr0239; identified by match to protein family HMM PF06042; hypothetical protein 233680 4443043 SPD_0242 Streptococcus pneumoniae D39 hypothetical protein YP_815760.1 233108 D 373153 CDS YP_815761.1 116515541 4442907 233911..234669 1 NC_008533.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase 234669 uppS 4442907 uppS Streptococcus pneumoniae D39 undecaprenyl pyrophosphate synthase YP_815761.1 233911 D 373153 CDS YP_815762.1 116516628 4441416 234678..235481 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0262; equivalent gene in S.pneumoniae R6 = spr0241; identified by match to protein family HMM PF01148; phosphatidate cytidylyltransferase 235481 cdsA 4441416 cdsA Streptococcus pneumoniae D39 phosphatidate cytidylyltransferase YP_815762.1 234678 D 373153 CDS YP_815763.1 116515700 4441442 235503..236762 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0263; equivalent gene in S.pneumoniae R6 = spr0242; identified by match to protein family HMM PF02163; match to protein family HMM TIGR00054; zinc metalloprotease Eep 236762 eep 4441442 eep Streptococcus pneumoniae D39 zinc metalloprotease Eep YP_815763.1 235503 D 373153 CDS YP_815764.1 116515963 4441404 236775..238628 1 NC_008533.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 238628 proS 4441404 proS Streptococcus pneumoniae D39 prolyl-tRNA synthetase YP_815764.1 236775 D 373153 CDS YP_815765.1 116516550 4441054 238728..240107 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0265; equivalent gene in S.pneumoniae R6 = spr0244; identified by match to protein family HMM PF00232; glycosyl hydrolase family protein 240107 4441054 SPD_0247 Streptococcus pneumoniae D39 glycosyl hydrolase family protein YP_815765.1 238728 D 373153 CDS YP_815766.1 116516194 4441452 240299..242107 1 NC_008533.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 242107 glmS 4441452 glmS Streptococcus pneumoniae D39 glucosamine--fructose-6-phosphate aminotransferase YP_815766.1 240299 D 373153 CDS YP_815767.1 116515457 4441182 242226..243275 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0267; equivalent gene in S.pneumoniae R6 = spr0246; identified by match to protein family HMM PF00296; hypothetical protein 243275 4441182 SPD_0249 Streptococcus pneumoniae D39 hypothetical protein YP_815767.1 242226 D 373153 CDS YP_815768.1 116515399 4442469 complement(243375..247145) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0268; equivalent gene in S.pneumoniae R6 = spr0247; identified by match to protein family HMM PF00128; match to protein family HMM PF00746; match to protein family HMM PF02922; match to protein family HMM PF03714; match to protein family HMM PF04650; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; match to protein family HMM TIGR02102; pullulanase, extracellular 247145 4442469 SPD_0250 Streptococcus pneumoniae D39 pullulanase, extracellular YP_815768.1 243375 R 373153 CDS YP_815769.1 116516309 4442792 247562..247975 1 NC_008533.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 247975 rpsL 4442792 rpsL Streptococcus pneumoniae D39 30S ribosomal protein S12 YP_815769.1 247562 D 373153 CDS YP_815770.1 116516917 4442066 247995..248465 1 NC_008533.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 248465 rpsG 4442066 rpsG Streptococcus pneumoniae D39 30S ribosomal protein S7 YP_815770.1 247995 D 373153 CDS YP_815771.1 116516752 4442302 248890..250971 1 NC_008533.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 250971 fusA 4442302 fusA Streptococcus pneumoniae D39 elongation factor G YP_815771.1 248890 D 373153 CDS YP_815772.1 116515846 4441537 251075..255466 1 NC_008533.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; required for leading strand synthesis; PolC exhibits 3' to 5' exonuclease activity; DNA polymerase III PolC 255466 polC 4441537 polC Streptococcus pneumoniae D39 DNA polymerase III PolC YP_815772.1 251075 D 373153 CDS YP_815773.1 116516886 4442129 255568..255831 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0275; equivalent gene in S.pneumoniae R6 = spr0252; identified by match to protein family HMM PF04221; match to protein family HMM TIGR02384; hypothetical protein 255831 4442129 SPD_0255 Streptococcus pneumoniae D39 hypothetical protein YP_815773.1 255568 D 373153 CDS YP_815774.1 116516116 4441641 255824..256102 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0276; equivalent gene in S.pneumoniae R6 = spr0253; identified by match to protein family HMM PF05016; match to protein family HMM TIGR02385; hypothetical protein 256102 4441641 SPD_0256 Streptococcus pneumoniae D39 hypothetical protein YP_815774.1 255824 D 373153 CDS YP_815775.1 116516451 4442571 256123..256275 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0277; hypothetical protein 256275 4442571 SPD_0257 Streptococcus pneumoniae D39 hypothetical protein YP_815775.1 256123 D 373153 CDS YP_815776.1 116516652 4443056 256297..257538 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0278; equivalent gene in S.pneumoniae R6 = spr0254; identified by match to protein family HMM PF02073; aminopeptidase PepS 257538 pepS 4443056 pepS Streptococcus pneumoniae D39 aminopeptidase PepS YP_815776.1 256297 D 373153 CDS YP_815777.1 116516350 4442952 257548..257778 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0279; equivalent gene in S.pneumoniae R6 = spr0255; identified by match to protein family HMM PF04226; hypothetical protein 257778 4442952 SPD_0259 Streptococcus pneumoniae D39 hypothetical protein YP_815777.1 257548 D 373153 CDS YP_815778.1 116516048 4442757 258091..258813 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0280; equivalent gene in S.pneumoniae R6 = spr0256; identified by match to protein family HMM PF00849; match to protein family HMM PF01479; match to protein family HMM TIGR00093; ribosomal small subunit pseudouridine synthase A 258813 rsuA-1 4442757 rsuA-1 Streptococcus pneumoniae D39 ribosomal small subunit pseudouridine synthase A YP_815778.1 258091 D 373153 CDS YP_815779.1 116516913 4442061 259030..260364 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0281; equivalent gene in S.pneumoniae R6 = spr0258; identified by match to protein family HMM PF03051; aminopeptidase C 260364 pepC 4442061 pepC Streptococcus pneumoniae D39 aminopeptidase C YP_815779.1 259030 D 373153 CDS YP_815780.1 116516955 4442908 complement(260420..261331) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0282; equivalent gene in S.pneumoniae R6 = spr0259; identified by match to protein family HMM PF03613; match to protein family HMM TIGR00828; PTS system, mannose/fructose/sorbose family protein, IID component 261331 4442908 SPD_0262 Streptococcus pneumoniae D39 PTS system, mannose/fructose/sorbose family protein, IID component YP_815780.1 260420 R 373153 CDS YP_815781.1 116515863 4441099 complement(261355..262158) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0283; equivalent gene in S.pneumoniae R6 = spr0260; identified by match to protein family HMM PF03609; PTS system mannose-specific transporter subunit IIC 262158 manM 4441099 manM Streptococcus pneumoniae D39 PTS system mannose-specific transporter subunit IIC YP_815781.1 261355 R 373153 CDS YP_815782.1 116515792 4441557 complement(262186..263175) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0284; equivalent gene in S.pneumoniae R6 = spr0261; identified by match to protein family HMM PF03610; match to protein family HMM PF03830; PTS system mannose-specific transporter subunit IIAB 263175 manL 4441557 manL Streptococcus pneumoniae D39 PTS system mannose-specific transporter subunit IIAB YP_815782.1 262186 R 373153 CDS YP_815783.1 116516519 4443070 complement(263408..264427) 1 NC_008533.1 similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs; alcohol dehydrogenase 264427 4443070 SPD_0265 Streptococcus pneumoniae D39 alcohol dehydrogenase YP_815783.1 263408 R 373153 CDS YP_815784.1 116516403 4442969 complement(264766..265578) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0286; equivalent gene in S.pneumoniae R6 = spr0263; identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; Cof family protein 265578 4442969 SPD_0266 Streptococcus pneumoniae D39 Cof family protein YP_815784.1 264766 R 373153 CDS YP_815785.1 116515488 4441298 265768..267186 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0287; equivalent gene in S.pneumoniae R6 = spr0264; identified by match to protein family HMM PF00860; xanthine/uracil permease family protein 267186 4441298 SPD_0267 Streptococcus pneumoniae D39 xanthine/uracil permease family protein YP_815785.1 265768 D 373153 CDS YP_815786.1 116516578 4442099 267255..267947 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0288; equivalent gene in S.pneumoniae R6 = spr0265; identified by match to protein family HMM PF02517; hypothetical protein 267947 4442099 SPD_0268 Streptococcus pneumoniae D39 hypothetical protein YP_815786.1 267255 D 373153 CDS YP_815787.1 116516653 4443057 268042..269016 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0289; equivalent gene in S.pneumoniae R6 = spr0266; identified by match to protein family HMM PF00809; match to protein family HMM TIGR01496; dihydropteroate synthase 269016 folP 4443057 folP Streptococcus pneumoniae D39 dihydropteroate synthase YP_815787.1 268042 D 373153 CDS YP_815788.1 116516745 4442295 269018..270340 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0290; equivalent gene in S.pneumoniae R6 = spr0267; identified by match to protein family HMM PF02875; match to protein family HMM TIGR01499; folylpolyglutamate synthase 270340 4442295 SPD_0270 Streptococcus pneumoniae D39 folylpolyglutamate synthase YP_815788.1 269018 D 373153 CDS YP_815789.1 116515945 4441347 270321..270875 1 NC_008533.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 270875 folE 4441347 folE Streptococcus pneumoniae D39 GTP cyclohydrolase I YP_815789.1 270321 D 373153 CDS YP_815790.1 116517074 4441924 270918..271730 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0292; equivalent gene in S.pneumoniae R6 = spr0269; identified by match to protein family HMM PF01288; match to protein family HMM PF02152; match to protein family HMM TIGR00525; match to protein family HMM TIGR00526; match to protein family HMM TIGR01498; bifunctional folate synthesis protein 271730 sulD 4441924 sulD Streptococcus pneumoniae D39 bifunctional folate synthesis protein YP_815790.1 270918 D 373153 CDS YP_815791.1 116516191 4441148 complement(271775..272146) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0293; equivalent gene in S.pneumoniae R6 = spr0270; hypothetical protein 272146 4441148 SPD_0273 Streptococcus pneumoniae D39 hypothetical protein YP_815791.1 271775 R 373153 CDS YP_815792.1 116516171 4442845 272449..272895 1 NC_008533.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 272895 rplM 4442845 rplM Streptococcus pneumoniae D39 50S ribosomal protein L13 YP_815792.1 272449 D 373153 CDS YP_815793.1 116517105 4441916 272915..273307 1 NC_008533.1 forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 273307 rpsI 4441916 rpsI Streptococcus pneumoniae D39 30S ribosomal protein S9 YP_815793.1 272915 D 373153 CDS YP_815794.1 116516562 4441267 273994..274359 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0302; equivalent gene in S.pneumoniae R6 = spr0275; identified by match to protein family HMM PF03992; hypothetical protein 274359 4441267 SPD_0276 Streptococcus pneumoniae D39 hypothetical protein YP_815794.1 273994 D 373153 CDS YP_815795.1 116515365 4441165 274549..275985 1 NC_008533.1 converts 6-phospho-beta-D-glucosyl-(1,4)-D-glucose to glucose and glucose 6-phosphate; required for cellobiose uptake and metabolism; 6-phospho-beta-glucosidase 275985 celA 4441165 celA Streptococcus pneumoniae D39 6-phospho-beta-glucosidase YP_815795.1 274549 D 373153 CDS YP_815796.1 116515676 4442542 276037..276276 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0304; equivalent gene in S.pneumoniae R6 = spr0277; identified by match to protein family HMM PF03083; hypothetical protein 276276 4442542 SPD_0278 Streptococcus pneumoniae D39 hypothetical protein YP_815796.1 276037 D 373153 CDS YP_815797.1 116517077 4441927 276406..276720 1 NC_008533.1 required for cellobiose uptake and metabolism; PTS system cellobiose transporter subunit IIB 276720 celB 4441927 celB Streptococcus pneumoniae D39 PTS system cellobiose transporter subunit IIB YP_815797.1 276406 D 373153 CDS YP_815798.1 116516527 4443078 276844..278817 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0306; equivalent gene in S.pneumoniae R6 = spr0279; identified by match to protein family HMM PF00874; match to protein family HMM PF05043; transcriptional regulator 278817 4443078 SPD_0280 Streptococcus pneumoniae D39 transcriptional regulator YP_815798.1 276844 D 373153 CDS YP_815799.1 116515730 4441018 278827..279141 1 NC_008533.1 required for cellobiose uptake and metabolism; cellobiose phosphotransferase system IIA component 279141 celC 4441018 celC Streptococcus pneumoniae D39 cellobiose phosphotransferase system IIA component YP_815799.1 278827 D 373153 CDS YP_815800.1 116515501 4441311 279160..279666 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0309; equivalent gene in S.pneumoniae R6 = spr0281; hypothetical protein 279666 4441311 SPD_0282 Streptococcus pneumoniae D39 hypothetical protein YP_815800.1 279160 D 373153 CDS YP_815801.1 116516546 4441050 279746..281092 1 NC_008533.1 required for cellobiose uptake and metabolism; cellobiose phosphotransferase system IIC component 281092 celD 4441050 celD Streptococcus pneumoniae D39 cellobiose phosphotransferase system IIC component YP_815801.1 279746 D 373153 CDS YP_815802.1 116515742 4441031 281474..281650 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0311; equivalent gene in S.pneumoniae R6 = spr0283; hypothetical protein 281650 4441031 SPD_0284 Streptococcus pneumoniae D39 hypothetical protein YP_815802.1 281474 D 373153 CDS YP_815803.1 116516613 4442390 282052..284265 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0312; equivalent gene in S.pneumoniae R6 = spr0284; identified by match to protein family HMM PF01055; glycosyl hydrolase family protein 284265 4442390 SPD_0285 Streptococcus pneumoniae D39 glycosyl hydrolase family protein YP_815803.1 282052 D 373153 CDS YP_815804.1 116516850 4442131 complement(284487..284963) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0313; equivalent gene in S.pneumoniae R6 = spr0285; identified by match to protein family HMM PF00255; glutathione peroxidase 284963 4442131 SPD_0286 Streptococcus pneumoniae D39 glutathione peroxidase YP_815804.1 284487 R 373153 CDS YP_815805.1 116515977 4442428 285186..288389 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0314; equivalent gene in S.pneumoniae R6 = spr0286; identified by match to protein family HMM PF00746; match to protein family HMM PF02018; match to protein family HMM PF02278; match to protein family HMM PF02884; match to protein family HMM PF08124; match to protein family HMM TIGR01167; hyaluronate lyase 288389 4442428 SPD_0287 Streptococcus pneumoniae D39 hyaluronate lyase YP_815805.1 285186 D 373153 CDS YP_815806.1 116515570 4442880 complement(289533..290162) 1 NC_008533.1 catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase 290162 eda 4442880 eda Streptococcus pneumoniae D39 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase YP_815806.1 289533 R 373153 CDS YP_815807.1 116516452 4442572 complement(290172..291173) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0318; equivalent gene in S.pneumoniae R6 = spr0288; identified by match to protein family HMM PF00294; PfkB family protein carbohydrate kinase 291173 4442572 SPD_0290 Streptococcus pneumoniae D39 PfkB family protein carbohydrate kinase YP_815807.1 290172 R 373153 CDS YP_815808.1 116515351 4441093 complement(291204..291845) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0319; equivalent gene in S.pneumoniae R6 = spr0289; identified by match to protein family HMM PF06562; hypothetical protein 291845 4441093 SPD_0291 Streptococcus pneumoniae D39 hypothetical protein YP_815808.1 291204 R 373153 CDS YP_815809.1 116516839 4442159 complement(291864..292679) 1 NC_008533.1 Involved in the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate; gluconate 5-dehydrogenase 292679 4442159 SPD_0292 Streptococcus pneumoniae D39 gluconate 5-dehydrogenase YP_815809.1 291864 R 373153 CDS YP_815810.1 116515558 4442732 292950..293384 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0321; equivalent gene in S.pneumoniae R6 = spr0291; identified by match to protein family HMM PF03610; PTS system transporter subunit IIA 293384 4442732 SPD_0293 Streptococcus pneumoniae D39 PTS system transporter subunit IIA YP_815810.1 292950 D 373153 CDS YP_815811.1 116517086 4441936 293396..294586 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0322; equivalent gene in S.pneumoniae R6 = spr0292; identified by match to protein family HMM PF07470; glucuronyl hydrolase 294586 4441936 SPD_0294 Streptococcus pneumoniae D39 glucuronyl hydrolase YP_815811.1 293396 D 373153 CDS YP_815812.1 116515823 4441114 294597..295088 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0323; equivalent gene in S.pneumoniae R6 = spr0293; identified by match to protein family HMM PF03830; PTS system transporter subunit IIB 295088 4441114 SPD_0295 Streptococcus pneumoniae D39 PTS system transporter subunit IIB YP_815812.1 294597 D 373153 CDS YP_815813.1 116515404 4442474 295103..295882 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0324; equivalent gene in S.pneumoniae R6 = spr0294; identified by match to protein family HMM PF03609; PTS system transporter subunit IIC 295882 4442474 SPD_0296 Streptococcus pneumoniae D39 PTS system transporter subunit IIC YP_815813.1 295103 D 373153 CDS YP_815814.1 116516087 4442681 295869..296687 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0325; equivalent gene in S.pneumoniae R6 = spr0295; identified by match to protein family HMM PF03613; PTS system transporter subunit IID 296687 4442681 SPD_0297 Streptococcus pneumoniae D39 PTS system transporter subunit IID YP_815814.1 295869 D 373153 CDS YP_815815.2 162139312 4442710 296687..296980 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0326; equivalent gene in S.pneumoniae R6 = spr0296; preprotein translocase subunit YajC 296980 yajC-1 4442710 yajC-1 Streptococcus pneumoniae D39 preprotein translocase subunit YajC YP_815815.2 296687 D 373153 CDS YP_815816.1 116516830 4442187 297002..297118 1 NC_008533.1 hypothetical protein 297118 4442187 SPD_0299 Streptococcus pneumoniae D39 hypothetical protein YP_815816.1 297002 D 373153 CDS YP_815817.1 116516834 4442153 297064..298902 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0327; equivalent gene in S.pneumoniae R6 = spr0297; identified by match to protein family HMM PF07940; hypothetical protein 298902 4442153 SPD_0300 Streptococcus pneumoniae D39 hypothetical protein YP_815817.1 297064 D 373153 CDS YP_815818.1 116515692 4441432 298962..299963 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0330; equivalent gene in S.pneumoniae R6 = spr0298; identified by match to protein family HMM PF00356; match to protein family HMM PF00532; sugar binding transcriptional regulator RegR 299963 regR 4441432 regR Streptococcus pneumoniae D39 sugar binding transcriptional regulator RegR YP_815818.1 298962 D 373153 CDS YP_815819.1 116516600 4441230 complement(300409..300651) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0300; hypothetical protein 300651 4441230 SPD_0302 Streptococcus pneumoniae D39 hypothetical protein YP_815819.1 300409 R 373153 CDS YP_815820.1 116515521 4443002 complement(300667..300861) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0333; equivalent gene in S.pneumoniae R6 = spr0301; identified by match to protein family HMM PF01381; transcriptional regulator 300861 4443002 SPD_0303 Streptococcus pneumoniae D39 transcriptional regulator YP_815820.1 300667 R 373153 CDS YP_815821.1 116515442 4441289 301027..301977 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0334; equivalent gene in S.pneumoniae R6 = spr0302; identified by match to protein family HMM PF01795; match to protein family HMM TIGR00006; S-adenosyl-methyltransferase MraW 301977 mraW 4441289 mraW Streptococcus pneumoniae D39 S-adenosyl-methyltransferase MraW YP_815821.1 301027 D 373153 CDS YP_815822.1 116516218 4441478 301989..302306 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0335; equivalent gene in S.pneumoniae R6 = spr0303; identified by match to protein family HMM TIGR02209; cell division protein FtsL 302306 ftsL 4441478 ftsL Streptococcus pneumoniae D39 cell division protein FtsL YP_815822.1 301989 D 373153 CDS YP_815823.1 116517037 4442351 302310..304562 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0336; equivalent gene in S.pneumoniae R6 = spr0304; identified by match to protein family HMM PF00905; match to protein family HMM PF03717; match to protein family HMM PF03793; penicillin-binding protein 2X 304562 pbpX 4442351 pbpX Streptococcus pneumoniae D39 penicillin-binding protein 2X YP_815823.1 302310 D 373153 CDS YP_815824.1 116515948 4441350 304564..305544 1 NC_008533.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 305544 mraY 4441350 mraY Streptococcus pneumoniae D39 phospho-N-acetylmuramoyl-pentapeptide- transferase YP_815824.1 304564 D 373153 CDS YP_815825.1 116515968 4441410 306101..308206 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0338; equivalent gene in S.pneumoniae R6 = spr0307; identified by match to protein family HMM PF00004; match to protein family HMM PF07724; match to protein family HMM PF07728; ATP-dependent Clp protease, ATP-binding subunit 308206 clpL 4441410 clpL Streptococcus pneumoniae D39 ATP-dependent Clp protease, ATP-binding subunit YP_815825.1 306101 D 373153 CDS YP_815826.1 116516199 4441459 complement(308502..308984) 1 NC_008533.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase 308984 luxS 4441459 luxS Streptococcus pneumoniae D39 S-ribosylhomocysteinase YP_815826.1 308502 R 373153 CDS YP_815827.1 116516184 4441141 complement(309079..310563) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0341; equivalent gene in S.pneumoniae R6 = spr0309; hypothetical protein 310563 4441141 SPD_0310 Streptococcus pneumoniae D39 hypothetical protein YP_815827.1 309079 R 373153 CDS YP_815828.1 116517011 4441956 310716..312323 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0342; equivalent gene in S.pneumoniae R6 = spr0310; identified by match to protein family HMM PF00128; glucan 1,6-alpha-glucosidase 312323 dexB 4441956 dexB Streptococcus pneumoniae D39 glucan 1,6-alpha-glucosidase YP_815828.1 310716 D 373153 CDS YP_815829.1 116516728 4442317 312482..312655 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0311; hypothetical protein 312655 4442317 SPD_0313 Streptococcus pneumoniae D39 hypothetical protein YP_815829.1 312482 D 373153 CDS YP_815830.1 116516963 4442916 313744..315189 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0346; equivalent gene in S.pneumoniae R6 = spr0314; identified by match to protein family HMM PF02916; match to protein family HMM PF03816; match to protein family HMM TIGR00350; integral membrane regulatory protein Cps2A 315189 cps2A 4442916 cps2A Streptococcus pneumoniae D39 integral membrane regulatory protein Cps2A YP_815830.1 313744 D 373153 CDS YP_815831.1 116516159 4442833 315191..315922 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0347; identified by match to protein family HMM PF02811; tyrosine-protein phosphatase CpsB 315922 cps2B 4442833 cps2B Streptococcus pneumoniae D39 tyrosine-protein phosphatase CpsB YP_815831.1 315191 D 373153 CDS YP_815832.1 116517039 4442353 315931..316623 1 NC_008533.1 identified by match to protein family HMM PF02706; match to protein family HMM TIGR01006; chain length determinant protein/polysaccharide export protein, MPA1 family protein 316623 cps2C 4442353 cps2C Streptococcus pneumoniae D39 chain length determinant protein/polysaccharide export protein, MPA1 family protein YP_815832.1 315931 D 373153 CDS YP_815833.1 116517023 4441968 316633..317313 1 NC_008533.1 identified by match to protein family HMM TIGR01007; tyrosine-protein kinase Cps2D cytosolic ATPase 317313 cps2D 4441968 cps2D Streptococcus pneumoniae D39 tyrosine-protein kinase Cps2D cytosolic ATPase YP_815833.1 316633 D 373153 CDS YP_815834.1 116516773 4442284 317328..318695 1 NC_008533.1 Cps2E catalyzes the reversible addition of Glc-1-phosphate from UDP-Glc to a polyprenyl phosphate acceptor; identified by match to protein family HMM PF02397; undecaprenylphosphate glucosephosphotransferase Cps2E 318695 cps2E 4442284 cps2E Streptococcus pneumoniae D39 undecaprenylphosphate glucosephosphotransferase Cps2E YP_815834.1 317328 D 373153 CDS YP_815835.1 116516453 4442573 318727..319911 1 NC_008533.1 identified by match to protein family HMM PF00534; glycoside hydrolase family protein 319911 cps2T 4442573 cps2T Streptococcus pneumoniae D39 glycoside hydrolase family protein YP_815835.1 318727 D 373153 CDS YP_815836.1 116516251 4441761 319904..320848 1 NC_008533.1 identified by match to protein family HMM PF00535; glycosyl transferase family protein 320848 cps2F 4441761 cps2F Streptococcus pneumoniae D39 glycosyl transferase family protein YP_815836.1 319904 D 373153 CDS YP_815837.1 116516693 4441367 320864..321910 1 NC_008533.1 identified by match to protein family HMM PF00534; glycoside hydrolase family protein 321910 cps2G 4441367 cps2G Streptococcus pneumoniae D39 glycoside hydrolase family protein YP_815837.1 320864 D 373153 CDS YP_815838.1 116515655 4441238 321951..323114 1 NC_008533.1 Part of the type 2 capsule locus. equivalent gene in S.pneumoniae R6 = spr0315; polysaccharide polymerase 323114 csp2H 4441238 csp2H Streptococcus pneumoniae D39 polysaccharide polymerase YP_815838.1 321951 D 373153 CDS YP_815839.1 116516743 4442293 323244..324401 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0316; identified by match to protein family HMM PF00534; glycoside hydrolase family protein 324401 cps2I 4442293 cps2I Streptococcus pneumoniae D39 glycoside hydrolase family protein YP_815839.1 323244 D 373153 CDS YP_815840.1 116516835 4442154 324398..325807 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0317; identified by match to protein family HMM PF01943; hypothetical protein 325807 4442154 SPD_0325 Streptococcus pneumoniae D39 hypothetical protein YP_815840.1 324398 D 373153 CDS YP_815841.1 116516033 4441693 325843..327081 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0318; identified by match to protein family HMM PF00984; match to protein family HMM PF01210; match to protein family HMM PF03720; match to protein family HMM PF03721; UDP-glucose 6-dehydrogenase 327081 cps2K 4441693 cps2K Streptococcus pneumoniae D39 UDP-glucose 6-dehydrogenase YP_815841.1 325843 D 373153 CDS YP_815842.1 116517147 4441861 327110..327715 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0319; identified by match to protein family HMM PF03275; UDP-galactopyranose mutase 327715 cps2P 4441861 cps2P Streptococcus pneumoniae D39 UDP-galactopyranose mutase YP_815842.1 327110 D 373153 CDS YP_815843.1 116516051 4442760 327793..328662 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0320; identified by match to protein family HMM PF00483; match to protein family HMM TIGR01207; glucose-1-phosphate thymidylyltransferase 328662 cps2L 4442760 cps2L Streptococcus pneumoniae D39 glucose-1-phosphate thymidylyltransferase YP_815843.1 327793 D 373153 CDS YP_815844.1 116517185 4441822 328663..329256 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0321; identified by match to protein family HMM PF00908; dTDP-4-dehydrorhamnose 3,5-epimerase 329256 rfbC 4441822 rfbC Streptococcus pneumoniae D39 dTDP-4-dehydrorhamnose 3,5-epimerase YP_815844.1 328663 D 373153 CDS YP_815845.1 116516812 4442169 329269..330318 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0322; identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF04321; match to protein family HMM PF07993; match to protein family HMM TIGR01181; dTDP-glucose 4,6-dehydratase 330318 rfbB 4442169 rfbB Streptococcus pneumoniae D39 dTDP-glucose 4,6-dehydratase YP_815845.1 329269 D 373153 CDS YP_815846.1 116515912 4441055 330384..331235 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0323; identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF04321; match to protein family HMM PF07993; match to protein family HMM TIGR01214; dTDP-4-dehydrorhamnose reductase 331235 rfbD 4441055 rfbD Streptococcus pneumoniae D39 dTDP-4-dehydrorhamnose reductase YP_815846.1 330384 D 373153 CDS YP_815847.1 116517053 4441941 332280..332438 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0808; equivalent gene in S.pneumoniae R6 = spr0326; hypothetical protein 332438 4441941 SPD_0333 Streptococcus pneumoniae D39 hypothetical protein YP_815847.1 332280 D 373153 CDS YP_815848.1 116515982 4442433 332640..334622 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0366; equivalent gene in S.pneumoniae R6 = spr0327; identified by match to protein family HMM PF00496; oligopeptide ABC transporter oligopeptide-binding protein AliA 334622 aliA 4442433 aliA Streptococcus pneumoniae D39 oligopeptide ABC transporter oligopeptide-binding protein AliA YP_815848.1 332640 D 373153 CDS YP_815849.1 116515461 4441186 334922..340225 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0368; equivalent gene in S.pneumoniae R6 = spr0328; identified by match to protein family HMM PF00754; match to protein family HMM PF04650; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; cell wall surface anchor family protein 340225 4441186 SPD_0335 Streptococcus pneumoniae D39 cell wall surface anchor family protein YP_815849.1 334922 D 373153 CDS YP_815850.1 116516330 4442813 complement(340392..342551) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0369; equivalent gene in S.pneumoniae R6 = spr0329; identified by match to protein family HMM PF00905; match to protein family HMM PF00912; match to protein family HMM TIGR02074; penicillin-binding protein 1A 342551 pbp1A 4442813 pbp1A Streptococcus pneumoniae D39 penicillin-binding protein 1A YP_815850.1 340392 R 373153 CDS YP_815851.1 116515550 4442724 complement(342548..343144) 1 NC_008533.1 functions in homologous recombination, DNA repair, and chromosome segregation; binds preferentially to three- and four-stranded DNA intermediates; introduces specific nick sites in four-stranded DNA substrates; functions similarly to Escherichia coli RuvC; Holliday junction-specific endonuclease 343144 recU 4442724 recU Streptococcus pneumoniae D39 Holliday junction-specific endonuclease YP_815851.1 342548 R 373153 CDS YP_815852.1 116516898 4442083 343210..343737 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0371; equivalent gene in S.pneumoniae R6 = spr0331; identified by match to protein family HMM PF06908; hypothetical protein 343737 4442083 SPD_0338 Streptococcus pneumoniae D39 hypothetical protein YP_815852.1 343210 D 373153 CDS YP_815853.1 116515799 4441564 343807..344136 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0372; equivalent gene in S.pneumoniae R6 = spr0332; identified by match to protein family HMM PF05103; hypothetical protein 344136 4441564 SPD_0339 Streptococcus pneumoniae D39 hypothetical protein YP_815853.1 343807 D 373153 CDS YP_815854.1 116517216 4441814 344622..345779 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0373; equivalent gene in S.pneumoniae R6 = spr0333; identified by match to protein family HMM PF01170; hypothetical protein 345779 4441814 SPD_0341 Streptococcus pneumoniae D39 hypothetical protein YP_815854.1 344622 D 373153 CDS YP_815855.1 116516323 4442806 345792..347186 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0374; equivalent gene in S.pneumoniae R6 = spr0334; hypothetical protein 347186 4442806 SPD_0342 Streptococcus pneumoniae D39 hypothetical protein YP_815855.1 345792 D 373153 CDS YP_815856.1 116515453 4441177 347262..348686 1 NC_008533.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase 348686 gnd 4441177 gnd Streptococcus pneumoniae D39 6-phosphogluconate dehydrogenase YP_815856.1 347262 D 373153 CDS YP_815857.1 116516655 4443059 348698..349387 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0376; equivalent gene in S.pneumoniae R6 = spr0336; identified by match to protein family HMM PF00072; match to protein family HMM PF00486; DNA-binding response regulator 349387 4443059 SPD_0344 Streptococcus pneumoniae D39 DNA-binding response regulator YP_815857.1 348698 D 373153 CDS YP_815858.1 116515498 4441308 349485..350501 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0337; identified by similarity to GB:AAK745441; match to protein family HMM PF01473; choline binding protein C 350501 cbpC 4441308 cbpC Streptococcus pneumoniae D39 choline binding protein C YP_815858.1 349485 D 373153 CDS YP_815859.1 116516899 4442084 350623..351501 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0381; equivalent gene in S.pneumoniae R6 = spr0338; identified by match to protein family HMM PF00288; match to protein family HMM TIGR00549; mevalonate kinase 351501 mvk 4442084 mvk Streptococcus pneumoniae D39 mevalonate kinase YP_815859.1 350623 D 373153 CDS YP_815860.1 116515775 4441675 351483..352436 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0382; equivalent gene in S.pneumoniae R6 = spr0339; identified by match to protein family HMM PF00288; match to protein family HMM TIGR01240; diphosphomevalonate decarboxylase 352436 mvaD 4441675 mvaD Streptococcus pneumoniae D39 diphosphomevalonate decarboxylase YP_815860.1 351483 D 373153 CDS YP_815861.1 116517118 4441890 352423..353430 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0383; equivalent gene in S.pneumoniae R6 = spr0340; identified by match to protein family HMM PF00288; match to protein family HMM TIGR01220; phosphomevalonate kinase 353430 mvaK2 4441890 mvaK2 Streptococcus pneumoniae D39 phosphomevalonate kinase YP_815861.1 352423 D 373153 CDS YP_815862.1 116515768 4441668 353414..354424 1 NC_008533.1 catalyzes the isomerization of isopentenyl pyrophosphate to dimethylallyl diphosphate; isopentenyl pyrophosphate isomerase 354424 fni 4441668 fni Streptococcus pneumoniae D39 isopentenyl pyrophosphate isomerase YP_815862.1 353414 D 373153 CDS YP_815863.1 116516981 4442001 354502..355200 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0385; equivalent gene in S.pneumoniae R6 = spr0342; hypothetical protein 355200 4442001 SPD_0350 Streptococcus pneumoniae D39 hypothetical protein YP_815863.1 354502 D 373153 CDS YP_815864.1 116515827 4441118 355197..356192 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0386; equivalent gene in S.pneumoniae R6 = spr0343; identified by match to protein family HMM PF02518; match to protein family HMM PF07730; sensor histidine kinase 356192 4441118 SPD_0351 Streptococcus pneumoniae D39 sensor histidine kinase YP_815864.1 355197 D 373153 CDS YP_815865.1 116517140 4442378 356206..356838 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0387; equivalent gene in S.pneumoniae R6 = spr0344; identified by match to protein family HMM PF00072; match to protein family HMM PF00196; DNA-binding response regulator 356838 4442378 SPD_0352 Streptococcus pneumoniae D39 DNA-binding response regulator YP_815865.1 356206 D 373153 CDS YP_815866.1 116516086 4442680 356839..356985 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0345; hypothetical protein 356985 4442680 SPD_0353 Streptococcus pneumoniae D39 hypothetical protein YP_815866.1 356839 D 373153 CDS YP_815867.1 116516504 4442625 357758..357952 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0389; equivalent gene in S.pneumoniae R6 = spr0348; hypothetical protein 357952 4442625 SPD_0355 Streptococcus pneumoniae D39 hypothetical protein YP_815867.1 357758 D 373153 CDS YP_815868.1 116515867 4441103 358922..359806 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0351; identified by match to protein family HMM PF01473; choline binding protein F 359806 cbpF 4441103 cbpF Streptococcus pneumoniae D39 choline binding protein F YP_815868.1 358922 D 373153 CDS YP_815869.1 116516093 4442687 complement(360868..361080) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1596; equivalent gene in S.pneumoniae R6 = spr0355; hypothetical protein 361080 4442687 SPD_0359 Streptococcus pneumoniae D39 hypothetical protein YP_815869.1 360868 R 373153 CDS YP_815870.1 116515741 4441030 361289..363058 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0394; equivalent gene in S.pneumoniae R6 = spr0356; identified by match to protein family HMM PF02302; match to protein family HMM PF02378; match to protein family HMM TIGR00851; PTS system mannitol-specific transporter subunit IIBC 363058 mtlA 4441030 mtlA Streptococcus pneumoniae D39 PTS system mannitol-specific transporter subunit IIBC YP_815870.1 361289 D 373153 CDS YP_815871.1 116516824 4442181 363082..365037 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0395; equivalent gene in S.pneumoniae R6 = spr0357; transcriptional regulator 365037 4442181 SPD_0361 Streptococcus pneumoniae D39 transcriptional regulator YP_815871.1 363082 D 373153 CDS YP_815872.1 116515528 4442892 365039..365476 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0396; equivalent gene in S.pneumoniae R6 = spr0358; identified by match to protein family HMM PF00359; PTS system, mannitol-specific enzyme IIA 365476 mtlA2 4442892 mtlA2 Streptococcus pneumoniae D39 PTS system, mannitol-specific enzyme IIA YP_815872.1 365039 D 373153 CDS YP_815873.1 116516528 4443079 365538..366674 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0397; equivalent gene in S.pneumoniae R6 = spr0359; identified by match to protein family HMM PF01232; match to protein family HMM PF08125; mannitol-1-phosphate 5-dehydrogenase 366674 4443079 SPD_0363 Streptococcus pneumoniae D39 mannitol-1-phosphate 5-dehydrogenase YP_815873.1 365538 D 373153 CDS YP_815874.1 116516231 4441511 367056..367169 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0399; equivalent gene in S.pneumoniae R6 = spr0361; polar amino acid ABC transporter ATPase 367169 4441511 SPD_0364 Streptococcus pneumoniae D39 polar amino acid ABC transporter ATPase YP_815874.1 367056 D 373153 CDS YP_815875.1 116516755 4442266 367473..368756 1 NC_008533.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 368756 tig 4442266 tig Streptococcus pneumoniae D39 trigger factor YP_815875.1 367473 D 373153 CDS YP_815876.1 116515818 4442866 complement(368804..371170) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0401; equivalent gene in S.pneumoniae R6 = spr0363; identified by match to protein family HMM TIGR01448; helicase, RecD/TraA family protein 371170 4442866 SPD_0366 Streptococcus pneumoniae D39 helicase, RecD/TraA family protein YP_815876.1 368804 R 373153 CDS YP_815877.1 116515681 4442547 complement(371404..372018) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0402; equivalent gene in S.pneumoniae R6 = spr0364; identified by match to protein family HMM PF00717; match to protein family HMM TIGR02227; signal peptidase I 372018 lepB 4442547 lepB Streptococcus pneumoniae D39 signal peptidase I YP_815877.1 371404 R 373153 CDS YP_815878.1 116516121 4442208 complement(372030..372902) 1 NC_008533.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease HIII 372902 rnhC 4442208 rnhC Streptococcus pneumoniae D39 ribonuclease HIII YP_815878.1 372030 R 373153 CDS YP_815879.1 116516919 4442068 372980..373291 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0404; equivalent gene in S.pneumoniae R6 = spr0366; hypothetical protein 373291 4442068 SPD_0369 Streptococcus pneumoniae D39 hypothetical protein YP_815879.1 372980 D 373153 CDS YP_815880.1 116515394 4442464 373288..373836 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0405; equivalent gene in S.pneumoniae R6 = spr0367; identified by match to protein family HMM PF02674; hypothetical protein 373836 4442464 SPD_0370 Streptococcus pneumoniae D39 hypothetical protein YP_815880.1 373288 D 373153 CDS YP_815881.1 116517220 4441818 373940..376276 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0406; equivalent gene in S.pneumoniae R6 = spr0368; identified by match to protein family HMM PF00488; match to protein family HMM PF01713; match to protein family HMM TIGR01069; MutS2 family protein 376276 4441818 SPD_0371 Streptococcus pneumoniae D39 MutS2 family protein YP_815881.1 373940 D 373153 CDS YP_815882.1 116515323 4442666 376618..377940 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0408; equivalent gene in S.pneumoniae R6 = spr0369; identified by match to protein family HMM PF01235; match to protein family HMM TIGR00835; sodium:alanine symporter family protein 377940 4442666 SPD_0372 Streptococcus pneumoniae D39 sodium:alanine symporter family protein YP_815882.1 376618 D 373153 CDS YP_815883.1 116516508 4442629 378158..378706 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0409; equivalent gene in S.pneumoniae R6 = spr0370; identified by match to protein family HMM PF02627; match to protein family HMM TIGR00778; hypothetical protein 378706 4442629 SPD_0373 Streptococcus pneumoniae D39 hypothetical protein YP_815883.1 378158 D 373153 CDS YP_815884.1 116516614 4442392 378816..379715 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0410; equivalent gene in S.pneumoniae R6 = spr0371; identified by match to protein family HMM PF03595; exfoliative toxin 379715 4442392 SPD_0374 Streptococcus pneumoniae D39 exfoliative toxin YP_815884.1 378816 D 373153 CDS YP_815885.1 116516325 4442808 complement(379740..381014) 1 NC_008533.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 381014 serS 4442808 serS Streptococcus pneumoniae D39 seryl-tRNA synthetase YP_815885.1 379740 R 373153 CDS YP_815886.1 116516387 4441593 complement(381227..381598) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0412; equivalent gene in S.pneumoniae R6 = spr0373; identified by match to protein family HMM PF06115; hypothetical protein 381598 4441593 SPD_0376 Streptococcus pneumoniae D39 hypothetical protein YP_815886.1 381227 R 373153 CDS YP_815887.1 116515794 4441559 complement(381601..382965) 1 NC_008533.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; lysine and threonine sensitive; aspartate kinase 382965 4441559 SPD_0377 Streptococcus pneumoniae D39 aspartate kinase YP_815887.1 381601 R 373153 CDS YP_815888.1 116516619 4442397 383290..384075 1 NC_008533.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 384075 4442397 SPD_0378 Streptococcus pneumoniae D39 enoyl-CoA hydratase YP_815888.1 383290 D 373153 CDS YP_815889.1 116516027 4441687 384169..384603 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0416; equivalent gene in S.pneumoniae R6 = spr0376; identified by match to protein family HMM PF01047; match to protein family HMM PF03965; transcriptional regulator, MarR family protein 384603 4441687 SPD_0379 Streptococcus pneumoniae D39 transcriptional regulator, MarR family protein YP_815889.1 384169 D 373153 CDS YP_815890.1 116516000 4441504 384603..385577 1 NC_008533.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-ACP synthase 385577 fabH 4441504 fabH Streptococcus pneumoniae D39 3-oxoacyl-ACP synthase YP_815890.1 384603 D 373153 CDS YP_815891.1 116516846 4442166 385637..385861 1 NC_008533.1 carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 385861 acpP 4442166 acpP Streptococcus pneumoniae D39 acyl carrier protein YP_815891.1 385637 D 373153 CDS YP_815892.1 116516513 4442635 385980..386954 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0419; equivalent gene in S.pneumoniae R6 = spr0379; identified by match to protein family HMM PF03060; trans-2-enoyl-ACP reductase II 386954 fabK 4442635 fabK Streptococcus pneumoniae D39 trans-2-enoyl-ACP reductase II YP_815892.1 385980 D 373153 CDS YP_815893.1 116517048 4442363 386947..387867 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0420; equivalent gene in S.pneumoniae R6 = spr0380; identified by match to protein family HMM PF00698; match to protein family HMM TIGR00128; acyl-carrier-protein S-malonyltransferase 387867 fabD 4442363 fabD Streptococcus pneumoniae D39 acyl-carrier-protein S-malonyltransferase YP_815893.1 386947 D 373153 CDS YP_815894.1 116515382 4441618 387901..388632 1 NC_008533.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 388632 fabG 4441618 fabG Streptococcus pneumoniae D39 3-ketoacyl-ACP reductase YP_815894.1 387901 D 373153 CDS YP_815895.1 116516059 4442768 388654..389889 1 NC_008533.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-(acyl carrier protein) synthase II 389889 fabF 4442768 fabF Streptococcus pneumoniae D39 3-oxoacyl-(acyl carrier protein) synthase II YP_815895.1 388654 D 373153 CDS YP_815896.1 116516115 4441640 389892..390377 1 NC_008533.1 composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 390377 accB 4441640 accB Streptococcus pneumoniae D39 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit YP_815896.1 389892 D 373153 CDS YP_815897.1 116516802 4442197 390374..390796 1 NC_008533.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 390796 fabZ 4442197 fabZ Streptococcus pneumoniae D39 (3R)-hydroxymyristoyl-ACP dehydratase YP_815897.1 390374 D 373153 CDS YP_815898.1 116515928 4441071 390808..392175 1 NC_008533.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxylase subunit 392175 accC 4441071 accC Streptococcus pneumoniae D39 acetyl-CoA carboxylase biotin carboxylase subunit YP_815898.1 390808 D 373153 CDS YP_815899.1 116515562 4442872 392212..393078 1 NC_008533.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta 393078 accD 4442872 accD Streptococcus pneumoniae D39 acetyl-CoA carboxylase subunit beta YP_815899.1 392212 D 373153 CDS YP_815900.1 116515640 4441320 393075..393842 1 NC_008533.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; these proteins present a shorter N-terminus; acetyl-CoA carboxylase subunit alpha 393842 accA 4441320 accA Streptococcus pneumoniae D39 acetyl-CoA carboxylase subunit alpha YP_815900.1 393075 D 373153 CDS YP_815901.1 116515989 4441492 394001..394186 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0429; equivalent gene in S.pneumoniae R6 = spr0388; hypothetical protein 394186 4441492 SPD_0391 Streptococcus pneumoniae D39 hypothetical protein YP_815901.1 394001 D 373153 CDS YP_815902.1 116516823 4442180 394443..394655 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0430; equivalent gene in S.pneumoniae R6 = spr0389; hypothetical protein 394655 4442180 SPD_0392 Streptococcus pneumoniae D39 hypothetical protein YP_815902.1 394443 D 373153 CDS YP_815903.1 116516227 4441487 complement(394953..395375) 1 NC_008533.1 Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 395375 nusB 4441487 nusB Streptococcus pneumoniae D39 transcription antitermination protein NusB YP_815903.1 394953 R 373153 CDS YP_815904.1 116516235 4441515 complement(395368..395757) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0434; equivalent gene in S.pneumoniae R6 = spr0391; identified by match to protein family HMM PF03780; hypothetical protein 395757 4441515 SPD_0394 Streptococcus pneumoniae D39 hypothetical protein YP_815904.1 395368 R 373153 CDS YP_815905.1 116516179 4441136 complement(395779..396339) 1 NC_008533.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 396339 efp 4441136 efp Streptococcus pneumoniae D39 elongation factor P YP_815905.1 395779 R 373153 CDS YP_815906.1 116515626 4442706 complement(396468..397910) 1 NC_008533.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit B 397910 gatB 4442706 gatB Streptococcus pneumoniae D39 aspartyl/glutamyl-tRNA amidotransferase subunit B YP_815906.1 396468 R 373153 CDS YP_815907.1 116516449 4442568 complement(397910..399376) 1 NC_008533.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; aspartyl/glutamyl-tRNA amidotransferase subunit A 399376 gatA 4442568 gatA Streptococcus pneumoniae D39 aspartyl/glutamyl-tRNA amidotransferase subunit A YP_815907.1 397910 R 373153 CDS YP_815908.1 116515845 4441536 complement(399376..399678) 1 NC_008533.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain; aspartyl/glutamyl-tRNA amidotransferase subunit C 399678 gatC 4441536 gatC Streptococcus pneumoniae D39 aspartyl/glutamyl-tRNA amidotransferase subunit C YP_815908.1 399376 R 373153 CDS YP_815909.1 116516944 4442020 399891..401435 1 NC_008533.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 401435 prfC 4442020 prfC Streptococcus pneumoniae D39 peptide chain release factor 3 YP_815909.1 399891 D 373153 CDS YP_815910.1 116515588 4441208 401704..402189 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0397; identified by match to protein family HMM PF01501; glycosyl transferase family protein 8 402189 4441208 SPD_0400 Streptococcus pneumoniae D39 glycosyl transferase family protein 8 YP_815910.1 401704 D 373153 CDS YP_815911.1 116515847 4441538 402305..402493 1 NC_008533.1 required for 70S ribosome assembly; 50S ribosomal protein L28 402493 rpmB 4441538 rpmB Streptococcus pneumoniae D39 50S ribosomal protein L28 YP_815911.1 402305 D 373153 CDS YP_815912.1 116516098 4442692 402650..403015 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0442; equivalent gene in S.pneumoniae R6 = spr0399; identified by match to protein family HMM PF03780; hypothetical protein 403015 4442692 SPD_0402 Streptococcus pneumoniae D39 hypothetical protein YP_815912.1 402650 D 373153 CDS YP_815913.1 116516992 4442013 403018..404685 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0443; equivalent gene in S.pneumoniae R6 = spr0400; identified by match to protein family HMM PF02734; hypothetical protein 404685 4442013 SPD_0403 Streptococcus pneumoniae D39 hypothetical protein YP_815913.1 403018 D 373153 CDS YP_815914.1 116516357 4442959 404886..406586 1 NC_008533.1 catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; acetolactate synthase catalytic subunit 406586 ilvB 4442959 ilvB Streptococcus pneumoniae D39 acetolactate synthase catalytic subunit YP_815914.1 404886 D 373153 CDS YP_815915.1 116515671 4441254 406579..407055 1 NC_008533.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 407055 ilvH 4441254 ilvH Streptococcus pneumoniae D39 acetolactate synthase 3 regulatory subunit YP_815915.1 406579 D 373153 CDS YP_815916.1 116517155 4441869 407121..408143 1 NC_008533.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 408143 ilvC 4441869 ilvC Streptococcus pneumoniae D39 ketol-acid reductoisomerase YP_815916.1 407121 D 373153 CDS YP_815917.1 116515821 4442869 408220..408486 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0448; equivalent gene in S.pneumoniae R6 = spr0404; hypothetical protein 408486 4442869 SPD_0407 Streptococcus pneumoniae D39 hypothetical protein YP_815917.1 408220 D 373153 CDS YP_815918.1 116515409 4442479 408724..409080 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0449; equivalent gene in S.pneumoniae R6 = spr0405; identified by similarity to GB:AAK992091; hypothetical protein 409080 4442479 SPD_0408 Streptococcus pneumoniae D39 hypothetical protein YP_815918.1 408724 D 373153 CDS YP_815919.1 116516499 4442620 409130..410380 1 NC_008533.1 catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic; threonine dehydratase 410380 ilvA 4442620 ilvA Streptococcus pneumoniae D39 threonine dehydratase YP_815919.1 409130 D 373153 CDS YP_815920.1 116515593 4441213 411115..411330 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0451; equivalent gene in S.pneumoniae R6 = spr0407; hypothetical protein 411330 4441213 SPD_0410 Streptococcus pneumoniae D39 hypothetical protein YP_815920.1 411115 D 373153 CDS YP_815921.1 116516673 4442454 complement(411439..412179) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0452; equivalent gene in S.pneumoniae R6 = spr0408; identified by match to protein family HMM PF00005; amino acid ABC transporter ATP-binding protein 412179 4442454 SPD_0411 Streptococcus pneumoniae D39 amino acid ABC transporter ATP-binding protein YP_815921.1 411439 R 373153 CDS YP_815922.1 116516213 4441473 complement(412179..413744) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0453; equivalent gene in S.pneumoniae R6 = spr0409; identified by match to protein family HMM PF00497; match to protein family HMM PF00528; match to protein family HMM TIGR01726; amino acid ABC transporter amino acid-binding protein/permease 413744 4441473 SPD_0412 Streptococcus pneumoniae D39 amino acid ABC transporter amino acid-binding protein/permease YP_815922.1 412179 R 373153 CDS YP_815923.1 116516530 4443081 413882..415771 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0454; equivalent gene in S.pneumoniae R6 = spr0410; hypothetical protein 415771 4443081 SPD_0414 Streptococcus pneumoniae D39 hypothetical protein YP_815923.1 413882 D 373153 CDS YP_815924.1 116517055 4441943 complement(415768..415929) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0411; hypothetical protein 415929 4441943 SPD_0413 Streptococcus pneumoniae D39 hypothetical protein YP_815924.1 415768 R 373153 CDS YP_815925.1 116515636 4441316 417195..418040 1 NC_008533.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; undecaprenyl pyrophosphate phosphatase 418040 bacA 4441316 bacA Streptococcus pneumoniae D39 undecaprenyl pyrophosphate phosphatase YP_815925.1 417195 D 373153 CDS YP_815926.1 116516463 4442933 418033..418161 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0346; hypothetical protein 418161 4442933 SPD_0418 Streptococcus pneumoniae D39 hypothetical protein YP_815926.1 418033 D 373153 CDS YP_815927.1 116516092 4442686 complement(418187..419248) 1 NC_008533.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 419248 dinP 4442686 dinP Streptococcus pneumoniae D39 DNA polymerase IV YP_815927.1 418187 R 373153 CDS YP_815928.1 116517188 4441825 419643..421967 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0459; equivalent gene in S.pneumoniae R6 = spr0415; identified by match to protein family HMM PF01228; match to protein family HMM PF02901; match to protein family HMM TIGR01255; formate acetyltransferase 421967 pflB 4441825 pflB Streptococcus pneumoniae D39 formate acetyltransferase YP_815928.1 419643 D 373153 CDS YP_815929.1 116516200 4441460 complement(422334..422681) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0416; hypothetical protein 422681 4441460 SPD_0421 Streptococcus pneumoniae D39 hypothetical protein YP_815929.1 422334 R 373153 CDS YP_815930.1 116515513 4442994 complement(422879..423163) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0471; equivalent gene in S.pneumoniae R6 = spr0417; hypothetical protein 423163 4442994 SPD_0422 Streptococcus pneumoniae D39 hypothetical protein YP_815930.1 422879 R 373153 CDS YP_815931.1 116517006 4441990 complement(424598..425821) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0473; equivalent gene in S.pneumoniae R6 = spr0420; identified by match to protein family HMM PF00480; ROK family protein 425821 4441990 SPD_0423 Streptococcus pneumoniae D39 ROK family protein YP_815931.1 424598 R 373153 CDS YP_815932.1 116515962 4441403 425989..427311 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0474; equivalent gene in S.pneumoniae R6 = spr0421; identified by match to protein family HMM PF02378; match to protein family HMM TIGR00410; PTS system cellobiose-specific transporter subunit IIC 427311 4441403 SPD_0424 Streptococcus pneumoniae D39 PTS system cellobiose-specific transporter subunit IIC YP_815932.1 425989 D 373153 CDS YP_815933.1 116515811 4442858 427313..429199 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0475; equivalent gene in S.pneumoniae R6 = spr0422; hypothetical protein 429199 4442858 SPD_0425 Streptococcus pneumoniae D39 hypothetical protein YP_815933.1 427313 D 373153 CDS YP_815934.1 116516902 4442087 429367..429711 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0476; equivalent gene in S.pneumoniae R6 = spr0423; identified by match to protein family HMM PF02255; PTS system lactose-specific transporter subunit IIA 429711 lacF-1 4442087 lacF-1 Streptococcus pneumoniae D39 PTS system lactose-specific transporter subunit IIA YP_815934.1 429367 D 373153 CDS YP_815935.1 116516482 4443011 429721..431133 1 NC_008533.1 catalyzes the formation of 6-phospho-galactose from a 6-phospho-beta-galactoside; 6-phospho-beta-galactosidase 431133 lacG-1 4443011 lacG-1 Streptococcus pneumoniae D39 6-phospho-beta-galactosidase YP_815935.1 429721 D 373153 CDS YP_815936.1 116515623 4442703 431202..432881 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0478; equivalent gene in S.pneumoniae R6 = spr0425; identified by match to protein family HMM PF02302; match to protein family HMM PF02378; PTS system lactose-specific transporter subunit IIBC 432881 lacE-1 4442703 lacE-1 Streptococcus pneumoniae D39 PTS system lactose-specific transporter subunit IIBC YP_815936.1 431202 D 373153 CDS YP_815937.1 116517119 4441891 complement(433009..434448) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0479; equivalent gene in S.pneumoniae R6 = spr0426; identified by match to protein family HMM PF02386; potassium uptake protein, Trk family protein 434448 4441891 SPD_0429 Streptococcus pneumoniae D39 potassium uptake protein, Trk family protein YP_815937.1 433009 R 373153 CDS YP_815938.1 116515316 4442659 complement(434452..435801) 1 NC_008533.1 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane protein 435801 trkA 4442659 trkA Streptococcus pneumoniae D39 potassium transporter peripheral membrane protein YP_815938.1 434452 R 373153 CDS YP_815939.1 116517130 4442368 435990..436838 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0481; equivalent gene in S.pneumoniae R6 = spr0428; identified by match to protein family HMM PF01887; hypothetical protein 436838 4442368 SPD_0431 Streptococcus pneumoniae D39 hypothetical protein YP_815939.1 435990 D 373153 CDS YP_815940.1 116515998 4441502 436853..437401 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0482; equivalent gene in S.pneumoniae R6 = spr0429; identified by match to protein family HMM PF07155; hypothetical protein 437401 4441502 SPD_0432 Streptococcus pneumoniae D39 hypothetical protein YP_815940.1 436853 D 373153 CDS YP_815941.1 116516686 4441360 437408..437620 1 NC_008533.1 hypothetical protein 437620 4441360 SPD_0433 Streptococcus pneumoniae D39 hypothetical protein YP_815941.1 437408 D 373153 CDS YP_815942.1 116516811 4442207 437722..439404 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0483; equivalent gene in S.pneumoniae R6 = spr0430; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 439404 4442207 SPD_0434 Streptococcus pneumoniae D39 ABC transporter ATP-binding protein YP_815942.1 437722 D 373153 CDS YP_815943.1 116516756 4442267 439389..440219 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0484; equivalent gene in S.pneumoniae R6 = spr0431; identified by match to protein family HMM PF02361; hypothetical protein 440219 4442267 SPD_0435 Streptococcus pneumoniae D39 hypothetical protein YP_815943.1 439389 D 373153 CDS YP_815944.1 116515392 4442462 440412..440915 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0486; equivalent gene in S.pneumoniae R6 = spr0432; identified by match to protein family HMM PF00588; TrmH family RNA methyltransferase 440915 4442462 SPD_0436 Streptococcus pneumoniae D39 TrmH family RNA methyltransferase YP_815944.1 440412 D 373153 CDS YP_815945.1 116516407 4442973 441374..441937 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0488; equivalent gene in S.pneumoniae R6 = spr0433; hypothetical protein 441937 4442973 SPD_0437 Streptococcus pneumoniae D39 hypothetical protein YP_815945.1 441374 D 373153 CDS YP_815946.1 116517046 4442360 441927..442577 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0489; equivalent gene in S.pneumoniae R6 = spr0434; identified by match to protein family HMM PF01569; PAP2 family protein 442577 4442360 SPD_0438 Streptococcus pneumoniae D39 PAP2 family protein YP_815946.1 441927 D 373153 CDS YP_815947.1 116517187 4441824 442605..442994 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0490; equivalent gene in S.pneumoniae R6 = spr0435; hypothetical protein 442994 4441824 SPD_0439 Streptococcus pneumoniae D39 hypothetical protein YP_815947.1 442605 D 373153 CDS YP_815948.1 116515870 4441106 442999..443448 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0492; equivalent gene in S.pneumoniae R6 = spr0436; hypothetical protein 443448 4441106 SPD_0440 Streptococcus pneumoniae D39 hypothetical protein YP_815948.1 442999 D 373153 CDS YP_815949.1 116516666 4442445 443576..444163 1 NC_008533.1 participates in both the initiation and recycling phases of transcription; in the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling; DNA-directed RNA polymerase subunit delta 444163 4442445 SPD_0441 Streptococcus pneumoniae D39 DNA-directed RNA polymerase subunit delta YP_815949.1 443576 D 373153 CDS YP_815950.1 116515581 4441199 444553..446160 1 NC_008533.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 446160 pyrG 4441199 pyrG Streptococcus pneumoniae D39 CTP synthetase YP_815950.1 444553 D 373153 CDS YP_815951.1 116515598 4442737 complement(446719..448350) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0496; equivalent gene in S.pneumoniae R6 = spr0439; identified by match to protein family HMM PF02690; match to protein family HMM TIGR00704; Na/Pi-cotransporter II-like protein 448350 4442737 SPD_0443 Streptococcus pneumoniae D39 Na/Pi-cotransporter II-like protein YP_815951.1 446719 R 373153 CDS YP_815952.1 116516927 4442040 448715..453622 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0498; equivalent gene in S.pneumoniae R6 = spr0440; identified by match to protein family HMM PF00746; match to protein family HMM PF00754; match to protein family HMM PF03644; match to protein family HMM PF07501; match to protein family HMM PF07523; match to protein family HMM PF07554; match to protein family HMM TIGR01167; endo-beta-N-acetylglucosaminidase 453622 4442040 SPD_0444 Streptococcus pneumoniae D39 endo-beta-N-acetylglucosaminidase YP_815952.1 448715 D 373153 CDS YP_815953.1 116516585 4442109 453712..454908 1 NC_008533.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 454908 pgk 4442109 pgk Streptococcus pneumoniae D39 phosphoglycerate kinase YP_815953.1 453712 D 373153 CDS YP_815954.1 116515489 4441299 455044..455571 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0500; equivalent gene in S.pneumoniae R6 = spr0442; hypothetical protein 455571 4441299 SPD_0446 Streptococcus pneumoniae D39 hypothetical protein YP_815954.1 455044 D 373153 CDS YP_815955.1 116517159 4441873 455648..456004 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0501; equivalent gene in S.pneumoniae R6 = spr0443; identified by match to protein family HMM PF00376; transcriptional regulator, MerR family protein 456004 4441873 SPD_0447 Streptococcus pneumoniae D39 transcriptional regulator, MerR family protein YP_815955.1 455648 D 373153 CDS YP_815956.1 116516090 4442684 456041..457387 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0502; equivalent gene in S.pneumoniae R6 = spr0444; identified by match to protein family HMM PF00120; match to protein family HMM PF03951; match to protein family HMM TIGR00653; glutamine synthetase, type I 457387 glnA 4442684 glnA Streptococcus pneumoniae D39 glutamine synthetase, type I YP_815956.1 456041 D 373153 CDS YP_815957.1 116516122 4442209 457860..457997 1 NC_008533.1 hypothetical protein 457997 4442209 SPD_0449 Streptococcus pneumoniae D39 hypothetical protein YP_815957.1 457860 D 373153 CDS YP_815958.1 116515880 4441377 458167..459447 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0445; identified by match to protein family HMM PF01420; type I restriction-modification system subunit S 459447 4441377 SPD_0451 Streptococcus pneumoniae D39 type I restriction-modification system subunit S YP_815958.1 458167 D 373153 CDS YP_815959.1 116516954 4442032 complement(459401..460000) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0507; equivalent gene in S.pneumoniae R6 = spr0446; identified by match to protein family HMM PF01420; type I restriction-modification system subunit S 460000 4442032 SPD_0450 Streptococcus pneumoniae D39 type I restriction-modification system subunit S YP_815959.1 459401 R 373153 CDS YP_815960.1 116515761 4442417 complement(460011..460808) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0506; equivalent gene in S.pneumoniae R6 = spr0447; identified by match to protein family HMM PF00589; integrase/recombinase, phage integrase family protein 460808 4442417 SPD_0452 Streptococcus pneumoniae D39 integrase/recombinase, phage integrase family protein YP_815960.1 460011 R 373153 CDS YP_815961.1 116515523 4443004 complement(460865..462433) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0448; identified by match to protein family HMM PF01420; type I restriction-modification system subunit S 462433 hsdS 4443004 hsdS Streptococcus pneumoniae D39 type I restriction-modification system subunit S YP_815961.1 460865 R 373153 CDS YP_815962.1 116516554 4441259 complement(462433..463896) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0509; equivalent gene in S.pneumoniae R6 = spr0449; identified by match to protein family HMM PF02384; match to protein family HMM PF05175; type I restriction-modification system, M subunit 463896 hsdM 4441259 hsdM Streptococcus pneumoniae D39 type I restriction-modification system, M subunit YP_815962.1 462433 R 373153 CDS YP_815963.1 116515646 4441326 complement(463909..466242) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0510; equivalent gene in S.pneumoniae R6 = spr0450; identified by match to protein family HMM PF00270; match to protein family HMM PF04313; match to protein family HMM PF04851; type I restriction-modification system, R subunit 466242 hsdR 4441326 hsdR Streptococcus pneumoniae D39 type I restriction-modification system, R subunit YP_815963.1 463909 R 373153 CDS YP_815964.1 116516914 4442063 466615..466815 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0512; equivalent gene in S.pneumoniae R6 = spr0451; hypothetical protein 466815 4442063 SPD_0456 Streptococcus pneumoniae D39 hypothetical protein YP_815964.1 466615 D 373153 CDS YP_815965.1 116515425 4442495 466850..467359 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0514; equivalent gene in S.pneumoniae R6 = spr0452; hypothetical protein 467359 4442495 SPD_0457 Streptococcus pneumoniae D39 hypothetical protein YP_815965.1 466850 D 373153 CDS YP_815966.1 116516738 4442288 467523..468557 1 NC_008533.1 Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons; heat-inducible transcription repressor 468557 hrcA 4442288 hrcA Streptococcus pneumoniae D39 heat-inducible transcription repressor YP_815966.1 467523 D 373153 CDS YP_815967.1 116517069 4441918 468584..469108 1 NC_008533.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 469108 grpE 4441918 grpE Streptococcus pneumoniae D39 heat shock protein GrpE YP_815967.1 468584 D 373153 CDS YP_815968.1 116516498 4442619 469588..471411 1 NC_008533.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 471411 dnaK 4442619 dnaK Streptococcus pneumoniae D39 molecular chaperone DnaK YP_815968.1 469588 D 373153 CDS YP_815969.1 116516829 4442186 472171..473289 1 NC_008533.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; chaperone protein DnaJ 473289 dnaJ 4442186 dnaJ Streptococcus pneumoniae D39 chaperone protein DnaJ YP_815969.1 472171 D 373153 CDS YP_815970.1 116516237 4441517 complement(473624..473911) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0520; equivalent gene in S.pneumoniae R6 = spr0457; hypothetical protein 473911 4441517 SPD_0462 Streptococcus pneumoniae D39 hypothetical protein YP_815970.1 473624 R 373153 CDS YP_815971.1 116516377 4443040 complement(473921..474331) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0521; equivalent gene in S.pneumoniae R6 = spr0458; identified by match to protein family HMM PF01230; cell-cycle regulation Hit-like protein 474331 4443040 SPD_0463 Streptococcus pneumoniae D39 cell-cycle regulation Hit-like protein YP_815971.1 473921 R 373153 CDS YP_815972.1 116515745 4441034 474399..475130 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0522; equivalent gene in S.pneumoniae R6 = spr0459; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 475130 4441034 SPD_0464 Streptococcus pneumoniae D39 ABC transporter ATP-binding protein YP_815972.1 474399 D 373153 CDS YP_815973.1 116516576 4442097 475127..476176 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0523; equivalent gene in S.pneumoniae R6 = spr0460; identified by match to protein family HMM PF05975; ABC transporter permease 476176 4442097 SPD_0465 Streptococcus pneumoniae D39 ABC transporter permease YP_815973.1 475127 D 373153 CDS YP_815974.1 116515782 4441682 complement(476344..476673) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0524; equivalent gene in S.pneumoniae R6 = spr0461; hypothetical protein 476673 4441682 SPD_0466 Streptococcus pneumoniae D39 hypothetical protein YP_815974.1 476344 R 373153 CDS YP_815975.1 116516604 4441234 476949..477287 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0525; equivalent gene in S.pneumoniae R6 = spr0462; identified by match to protein family HMM PF04397; BlpS protein 477287 blpS 4441234 blpS Streptococcus pneumoniae D39 BlpS protein YP_815975.1 476949 D 373153 CDS YP_815976.1 116515330 4442673 477292..478029 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0526; equivalent gene in S.pneumoniae R6 = spr0463; identified by match to protein family HMM PF00072; match to protein family HMM PF04397; response regulator BlpR 478029 blpR 4442673 blpR Streptococcus pneumoniae D39 response regulator BlpR YP_815976.1 477292 D 373153 CDS YP_815977.1 116515327 4442670 478043..479383 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0464; identified by match to protein family HMM PF02518; histidine kinase BlpH 479383 blpH 4442670 blpH Streptococcus pneumoniae D39 histidine kinase BlpH YP_815977.1 478043 D 373153 CDS YP_815978.1 116516214 4441474 complement(479425..479580) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0528; equivalent gene in S.pneumoniae R6 = spr0465; identified by match to protein family HMM PF08128; match to protein family HMM TIGR01847; peptide pheromone BlpC 479580 blpC 4441474 blpC Streptococcus pneumoniae D39 peptide pheromone BlpC YP_815978.1 479425 R 373153 CDS YP_815979.1 116516302 4442591 483721..484410 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0545; equivalent gene in S.pneumoniae R6 = spr0472; identified by match to protein family HMM PF02517; immunity protein BlpY 484410 blpY 4442591 blpY Streptococcus pneumoniae D39 immunity protein BlpY YP_815979.1 483721 D 373153 CDS YP_815980.1 116517135 4442373 484452..484685 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0546; equivalent gene in S.pneumoniae R6 = spr0473; hypothetical protein 484685 4442373 SPD_0474 Streptococcus pneumoniae D39 hypothetical protein YP_815980.1 484452 D 373153 CDS YP_815981.1 116515839 4441530 484836..485447 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0547; equivalent gene in S.pneumoniae R6 = spr0474; identified by match to protein family HMM PF02517; CAAX amino terminal protease family protein 485447 4441530 SPD_0475 Streptococcus pneumoniae D39 CAAX amino terminal protease family protein YP_815981.1 484836 D 373153 CDS YP_815982.1 116516934 4442049 485608..486402 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0549; equivalent gene in S.pneumoniae R6 = spr0475; identified by match to protein family HMM PF01636; hypothetical protein 486402 4442049 SPD_0476 Streptococcus pneumoniae D39 hypothetical protein YP_815982.1 485608 D 373153 CDS YP_815983.1 116515622 4442702 486399..487034 1 NC_008533.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 487034 trmB 4442702 trmB Streptococcus pneumoniae D39 tRNA (guanine-N(7)-)-methyltransferase YP_815983.1 486399 D 373153 CDS YP_815984.1 116516675 4442456 487160..487639 1 NC_008533.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein 487639 4442456 SPD_0478 Streptococcus pneumoniae D39 hypothetical protein YP_815984.1 487160 D 373153 CDS YP_815985.1 116515364 4441164 487683..488819 1 NC_008533.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 488819 nusA 4441164 nusA Streptococcus pneumoniae D39 transcription elongation factor NusA YP_815985.1 487683 D 373153 CDS YP_815986.1 116516304 4442593 488841..489134 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0554; equivalent gene in S.pneumoniae R6 = spr0479; identified by match to protein family HMM PF04296; hypothetical protein 489134 4442593 SPD_0480 Streptococcus pneumoniae D39 hypothetical protein YP_815986.1 488841 D 373153 CDS YP_815987.1 116515722 4442260 489127..489426 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0555; equivalent gene in S.pneumoniae R6 = spr0480; identified by match to protein family HMM PF01248; hypothetical protein 489426 4442260 SPD_0481 Streptococcus pneumoniae D39 hypothetical protein YP_815987.1 489127 D 373153 CDS YP_815988.1 116516588 4441217 489443..492235 1 NC_008533.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 492235 infB 4441217 infB Streptococcus pneumoniae D39 translation initiation factor IF-2 YP_815988.1 489443 D 373153 CDS YP_815989.1 116515755 4442410 492486..492836 1 NC_008533.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A 492836 rbfA 4442410 rbfA Streptococcus pneumoniae D39 ribosome-binding factor A YP_815989.1 492486 D 373153 CDS YP_815990.1 116516405 4442971 493079..493894 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0558; equivalent gene in S.pneumoniae R6 = spr0483; hypothetical protein 493894 4442971 SPD_0484 Streptococcus pneumoniae D39 hypothetical protein YP_815990.1 493079 D 373153 CDS YP_815991.1 116515503 4441313 493896..494078 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0484; hypothetical protein 494078 4441313 SPD_0485 Streptococcus pneumoniae D39 hypothetical protein YP_815991.1 493896 D 373153 CDS YP_815992.1 116515842 4441533 494075..494215 1 NC_008533.1 hypothetical protein 494215 4441533 SPD_0486 Streptococcus pneumoniae D39 hypothetical protein YP_815992.1 494075 D 373153 CDS YP_815993.1 116517210 4441808 494516..494761 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0561; equivalent gene in S.pneumoniae R6 = spr0485; hypothetical protein 494761 4441808 SPD_0487 Streptococcus pneumoniae D39 hypothetical protein YP_815993.1 494516 D 373153 CDS YP_815994.1 116515574 4442884 494761..496095 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0562; equivalent gene in S.pneumoniae R6 = spr0486; identified by match to protein family HMM PF01814; match to protein family HMM PF04282; hypothetical protein 496095 4442884 SPD_0488 Streptococcus pneumoniae D39 hypothetical protein YP_815994.1 494761 D 373153 CDS YP_815995.1 116516960 4442913 496105..496359 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0563; equivalent gene in S.pneumoniae R6 = spr0487; hypothetical protein 496359 4442913 SPD_0489 Streptococcus pneumoniae D39 hypothetical protein YP_815995.1 496105 D 373153 CDS YP_815996.1 116515740 4441029 496455..496850 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0564; equivalent gene in S.pneumoniae R6 = spr0488; hypothetical protein 496850 4441029 SPD_0490 Streptococcus pneumoniae D39 hypothetical protein YP_815996.1 496455 D 373153 CDS YP_815997.1 116516878 4442121 497262..497711 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0565; equivalent gene in S.pneumoniae R6 = spr0489; hypothetical protein 497711 4442121 SPD_0491 Streptococcus pneumoniae D39 hypothetical protein YP_815997.1 497262 D 373153 CDS YP_815998.1 116517161 4441875 497698..498255 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0490; identified by match to protein family HMM PF00583; GNAT family acetyltransferase 498255 4441875 SPD_0492 Streptococcus pneumoniae D39 GNAT family acetyltransferase YP_815998.1 497698 D 373153 CDS YP_815999.1 116515713 4442250 498257..499219 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0491; hypothetical protein 499219 4442250 SPD_0493 Streptococcus pneumoniae D39 hypothetical protein YP_815999.1 498257 D 373153 CDS YP_816000.1 116516342 4442827 499231..501882 1 NC_008533.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 501882 valS 4442827 valS Streptococcus pneumoniae D39 valyl-tRNA synthetase YP_816000.1 499231 D 373153 CDS YP_816001.1 116516856 4442137 501952..502707 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0493; hypothetical protein 502707 4442137 SPD_0495 Streptococcus pneumoniae D39 hypothetical protein YP_816001.1 501952 D 373153 CDS YP_816002.1 116516013 4441575 502990..503793 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0571; equivalent gene in S.pneumoniae R6 = spr0494; identified by match to protein family HMM PF02661; cell filamentation protein Fic-like protein 503793 4441575 SPD_0496 Streptococcus pneumoniae D39 cell filamentation protein Fic-like protein YP_816002.1 502990 D 373153 CDS YP_816003.1 116516401 4442967 complement(504947..505159) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1596; equivalent gene in S.pneumoniae R6 = spr0498; hypothetical protein 505159 4442967 SPD_0499 Streptococcus pneumoniae D39 hypothetical protein YP_816003.1 504947 R 373153 CDS YP_816004.1 116516805 4442201 508402..509241 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0576; equivalent gene in S.pneumoniae R6 = spr0504; identified by match to protein family HMM PF00874; match to protein family HMM PF03123; transcription antiterminator Lict 509241 licT 4442201 licT Streptococcus pneumoniae D39 transcription antiterminator Lict YP_816004.1 508402 D 373153 CDS YP_816005.1 116515619 4442699 509259..511097 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0577; equivalent gene in S.pneumoniae R6 = spr0505; identified by match to protein family HMM PF00358; match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00830; match to protein family HMM TIGR01995; PTS system beta-glucosides-specific transporter subunit IIABC 511097 4442699 SPD_0502 Streptococcus pneumoniae D39 PTS system beta-glucosides-specific transporter subunit IIABC YP_816005.1 509259 D 373153 CDS YP_816006.1 116515964 4441405 511110..512525 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0578; equivalent gene in S.pneumoniae R6 = spr0506; identified by match to protein family HMM PF00232; 6-phospho-beta-glucosidase 512525 bglA-2 4441405 bglA-2 Streptococcus pneumoniae D39 6-phospho-beta-glucosidase YP_816006.1 511110 D 373153 CDS YP_816007.1 116516862 4442144 513117..514163 1 NC_008533.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 514163 pheS 4442144 pheS Streptococcus pneumoniae D39 phenylalanyl-tRNA synthetase subunit alpha YP_816007.1 513117 D 373153 CDS YP_816008.1 116516224 4441484 514163..514672 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0580; equivalent gene in S.pneumoniae R6 = spr0508; identified by match to protein family HMM PF00583; GNAT family acetyltransferase 514672 4441484 SPD_0505 Streptococcus pneumoniae D39 GNAT family acetyltransferase YP_816008.1 514163 D 373153 CDS YP_816009.1 116517104 4441915 514749..517151 1 NC_008533.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 517151 pheT 4441915 pheT Streptococcus pneumoniae D39 phenylalanyl-tRNA synthetase subunit beta YP_816009.1 514749 D 373153 CDS YP_816010.1 116515991 4441494 complement(517219..518220) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0582; equivalent gene in S.pneumoniae R6 = spr0510; identified by match to protein family HMM PF03372; hypothetical protein 518220 4441494 SPD_0507 Streptococcus pneumoniae D39 hypothetical protein YP_816010.1 517219 R 373153 CDS YP_816011.1 116515852 4441544 518949..519215 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1144; equivalent gene in S.pneumoniae R6 = spr0513; identified by match to protein family HMM PF01381; hypothetical protein 519215 4441544 SPD_0509 Streptococcus pneumoniae D39 hypothetical protein YP_816011.1 518949 D 373153 CDS YP_816012.1 116516990 4442011 519476..521725 1 NC_008533.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase 521725 metE 4442011 metE Streptococcus pneumoniae D39 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase YP_816012.1 519476 D 373153 CDS YP_816013.1 116516593 4441222 521789..522655 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0586; equivalent gene in S.pneumoniae R6 = spr0515; identified by match to protein family HMM PF02219; match to protein family HMM TIGR00676; 5,10-methylenetetrahydrofolate reductase 522655 metF 4441222 metF Streptococcus pneumoniae D39 5,10-methylenetetrahydrofolate reductase YP_816013.1 521789 D 373153 CDS YP_816014.1 116515732 4441020 523226..525553 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0588; equivalent gene in S.pneumoniae R6 = spr0516; identified by match to protein family HMM PF00013; match to protein family HMM PF00575; match to protein family HMM PF01138; match to protein family HMM PF03725; match to protein family HMM PF03726; polynucleotide phosphorylase/polyadenylase 525553 pnp 4441020 pnp Streptococcus pneumoniae D39 polynucleotide phosphorylase/polyadenylase YP_816014.1 523226 D 373153 CDS YP_816015.1 116516473 4442943 525569..526186 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0589; equivalent gene in S.pneumoniae R6 = spr0517; identified by match to protein family HMM TIGR01172; serine O-acetyltransferase 526186 cysE 4442943 cysE Streptococcus pneumoniae D39 serine O-acetyltransferase YP_816015.1 525569 D 373153 CDS YP_816016.1 116515456 4441181 526198..527082 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0590; equivalent gene in S.pneumoniae R6 = spr0518; identified by match to protein family HMM PF00583; GNAT family acetyltransferase 527082 4441181 SPD_0514 Streptococcus pneumoniae D39 GNAT family acetyltransferase YP_816016.1 526198 D 373153 CDS YP_816017.1 116517189 4441826 527164..528507 1 NC_008533.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 528507 cysS 4441826 cysS Streptococcus pneumoniae D39 cysteinyl-tRNA synthetase YP_816017.1 527164 D 373153 CDS YP_816018.1 116515371 4441171 528500..528886 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0592; equivalent gene in S.pneumoniae R6 = spr0520; hypothetical protein 528886 4441171 SPD_0516 Streptococcus pneumoniae D39 hypothetical protein YP_816018.1 528500 D 373153 CDS YP_816019.1 116516580 4442102 528890..529774 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0593; equivalent gene in S.pneumoniae R6 = spr0521; hypothetical protein 529774 4442102 SPD_0517 Streptococcus pneumoniae D39 hypothetical protein YP_816019.1 528890 D 373153 CDS YP_816020.1 116515354 4441154 529911..530366 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0595; equivalent gene in S.pneumoniae R6 = spr0522; hypothetical protein 530366 4441154 SPD_0518 Streptococcus pneumoniae D39 hypothetical protein YP_816020.1 529911 D 373153 CDS YP_816021.1 116516174 4442848 530363..530509 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0596; hypothetical protein 530509 4442848 SPD_0519 Streptococcus pneumoniae D39 hypothetical protein YP_816021.1 530363 D 373153 CDS YP_816022.1 116517009 4441993 530655..530828 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0523; transposase, , truncation 530828 4441993 SPD_0520 Streptococcus pneumoniae D39 transposase, , truncation YP_816022.1 530655 D 373153 CDS YP_816023.1 116515844 4441535 531180..532457 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0599; equivalent gene in S.pneumoniae R6 = spr0524; identified by match to protein family HMM PF02687; ABC transporter 532457 vex1 4441535 vex1 Streptococcus pneumoniae D39 ABC transporter YP_816023.1 531180 D 373153 CDS YP_816024.1 116516662 4442441 532470..533117 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0600; equivalent gene in S.pneumoniae R6 = spr0525; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 533117 vex2 4442441 vex2 Streptococcus pneumoniae D39 ABC transporter ATP-binding protein YP_816024.1 532470 D 373153 CDS YP_816025.1 116515629 4442709 533169..534548 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0601; equivalent gene in S.pneumoniae R6 = spr0526; identified by match to protein family HMM PF02687; ABC transporter 534548 vex3 4442709 vex3 Streptococcus pneumoniae D39 ABC transporter YP_816025.1 533169 D 373153 CDS YP_816026.1 116516514 4443065 534860..535516 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0603; equivalent gene in S.pneumoniae R6 = spr0528; identified by match to protein family HMM PF00072; match to protein family HMM PF00486; DNA-binding response regulator VncR 535516 vncR 4443065 vncR Streptococcus pneumoniae D39 DNA-binding response regulator VncR YP_816026.1 534860 D 373153 CDS YP_816027.1 116515343 4441085 535513..536841 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0604; equivalent gene in S.pneumoniae R6 = spr0529; identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; sensor histidine kinase VncS 536841 vncS 4441085 vncS Streptococcus pneumoniae D39 sensor histidine kinase VncS YP_816027.1 535513 D 373153 CDS YP_816028.1 116515860 4441096 536982..537863 1 NC_008533.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase 537863 fba 4441096 fba Streptococcus pneumoniae D39 fructose-bisphosphate aldolase YP_816028.1 536982 D 373153 CDS YP_816029.1 116515686 4442552 complement(538184..539374) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0606; equivalent gene in S.pneumoniae R6 = spr0531; identified by match to protein family HMM PF00175; match to protein family HMM PF00970; match to protein family HMM PF01794; oxidoreductase 539374 4442552 SPD_0527 Streptococcus pneumoniae D39 oxidoreductase YP_816029.1 538184 R 373153 CDS YP_816030.1 116516319 4442802 complement(539632..540291) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0607; equivalent gene in S.pneumoniae R6 = spr0532; identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; amino acid ABC transporter permease 540291 4442802 SPD_0528 Streptococcus pneumoniae D39 amino acid ABC transporter permease YP_816030.1 539632 R 373153 CDS YP_816031.1 116515469 4442639 complement(540301..540978) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0608; equivalent gene in S.pneumoniae R6 = spr0533; identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; amino acid ABC transporter permease 540978 4442639 SPD_0529 Streptococcus pneumoniae D39 amino acid ABC transporter permease YP_816031.1 540301 R 373153 CDS YP_816032.1 116516520 4443071 complement(540991..541785) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0609; equivalent gene in S.pneumoniae R6 = spr0534; identified by match to protein family HMM PF00497; amino acid ABC transporter amino acid-binding protein 541785 4443071 SPD_0530 Streptococcus pneumoniae D39 amino acid ABC transporter amino acid-binding protein YP_816032.1 540991 R 373153 CDS YP_816033.1 116517143 4442381 542831..545053 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0611; equivalent gene in S.pneumoniae R6 = spr0537; identified by match to protein family HMM PF01368; match to protein family HMM PF02272; match to protein family HMM TIGR00644; single-stranded-DNA-specific exonuclease RecJ 545053 recJ 4442381 recJ Streptococcus pneumoniae D39 single-stranded-DNA-specific exonuclease RecJ YP_816033.1 542831 D 373153 CDS YP_816034.1 116516084 4442678 545228..546889 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0613; equivalent gene in S.pneumoniae R6 = spr0538; identified by match to protein family HMM PF00753; match to protein family HMM PF07521; metallo-beta-lactamase superfamily protein 546889 4442678 SPD_0533 Streptococcus pneumoniae D39 metallo-beta-lactamase superfamily protein YP_816034.1 545228 D 373153 CDS YP_816035.1 116516440 4442559 546958..547737 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0614; equivalent gene in S.pneumoniae R6 = spr0539; identified by match to protein family HMM PF00756; tributyrin esterase 547737 estA 4442559 estA Streptococcus pneumoniae D39 tributyrin esterase YP_816035.1 546958 D 373153 CDS YP_816036.1 116515318 4442661 547849..549069 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0615; equivalent gene in S.pneumoniae R6 = spr0540; identified by match to protein family HMM PF02388; serine/alanine-adding enzyme MurM 549069 murM/fibA 4442661 murM/fibA Streptococcus pneumoniae D39 serine/alanine-adding enzyme MurM YP_816036.1 547849 D 373153 CDS YP_816037.1 116515311 4441193 549074..550306 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0616; equivalent gene in S.pneumoniae R6 = spr0541; identified by match to protein family HMM PF02388; beta-lactam resistance factor 550306 fibB 4441193 fibB Streptococcus pneumoniae D39 beta-lactam resistance factor YP_816037.1 549074 D 373153 CDS YP_816038.1 116516355 4442957 550422..551081 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0617; equivalent gene in S.pneumoniae R6 = spr0542; identified by match to protein family HMM PF00413; hypothetical protein 551081 4442957 SPD_0537 Streptococcus pneumoniae D39 hypothetical protein YP_816038.1 550422 D 373153 CDS YP_816039.1 116515431 4441278 551121..552965 1 NC_008533.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 552965 uvrC 4441278 uvrC Streptococcus pneumoniae D39 excinuclease ABC subunit C YP_816039.1 551121 D 373153 CDS YP_816040.1 116516068 4442524 552955..553788 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0619; equivalent gene in S.pneumoniae R6 = spr0544; identified by match to protein family HMM PF00149; Ser/Thr protein phosphatase family protein 553788 4442524 SPD_0539 Streptococcus pneumoniae D39 Ser/Thr protein phosphatase family protein YP_816040.1 552955 D 373153 CDS YP_816041.1 116517131 4442369 complement(553970..554770) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0620; equivalent gene in S.pneumoniae R6 = spr0545; identified by match to protein family HMM PF00497; amino acid ABC transporter amino acid-binding protein 554770 4442369 SPD_0540 Streptococcus pneumoniae D39 amino acid ABC transporter amino acid-binding protein YP_816041.1 553970 R 373153 CDS YP_816042.1 116516933 4442048 554941..555546 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0622; equivalent gene in S.pneumoniae R6 = spr0546; identified by match to protein family HMM PF00881; nitroreductase family protein 555546 4442048 SPD_0541 Streptococcus pneumoniae D39 nitroreductase family protein YP_816042.1 554941 D 373153 CDS YP_816043.1 116515781 4441681 555559..556959 1 NC_008533.1 divalent metal ion-dependent extracellular dipeptidase; able to hydrolyze a broad range of dipeptides but no tri-, tetra-, or larger oligopeptides; differences in the amino acid specificity of the cleavage site varies between species; similar to succinyl-diaminopimelate desuccinylases; dipeptidase PepV 556959 pepV 4441681 pepV Streptococcus pneumoniae D39 dipeptidase PepV YP_816043.1 555559 D 373153 CDS YP_816044.1 116517025 4441970 557013..557591 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0624; equivalent gene in S.pneumoniae R6 = spr0548; identified by match to protein family HMM PF03167; hypothetical protein 557591 4441970 SPD_0543 Streptococcus pneumoniae D39 hypothetical protein YP_816044.1 557013 D 373153 CDS YP_816045.1 116515955 4441396 557755..557907 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0549; hypothetical protein 557907 4441396 SPD_0544 Streptococcus pneumoniae D39 hypothetical protein YP_816045.1 557755 D 373153 CDS YP_816046.1 116515508 4442989 557908..558042 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0550; hypothetical protein 558042 4442989 SPD_0545 Streptococcus pneumoniae D39 hypothetical protein YP_816046.1 557908 D 373153 CDS YP_816047.1 116516855 4442136 558213..559538 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0626; equivalent gene in S.pneumoniae R6 = spr0551; identified by match to protein family HMM PF05525; match to protein family HMM TIGR00796; branched-chain amino acid transport system II carrier protein 559538 brnQ 4442136 brnQ Streptococcus pneumoniae D39 branched-chain amino acid transport system II carrier protein YP_816047.1 558213 D 373153 CDS YP_816048.1 116516393 4441600 559742..560779 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0627; equivalent gene in S.pneumoniae R6 = spr0552; identified by match to protein family HMM PF05343; hypothetical protein 560779 4441600 SPD_0547 Streptococcus pneumoniae D39 hypothetical protein YP_816048.1 559742 D 373153 CDS YP_816049.1 116515557 4442731 560748..561251 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0628; equivalent gene in S.pneumoniae R6 = spr0553; identified by match to protein family HMM PF01230; HIT family protein 561251 4442731 SPD_0548 Streptococcus pneumoniae D39 HIT family protein YP_816049.1 560748 D 373153 CDS YP_816050.1 116516570 4441275 561254..561970 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0629; equivalent gene in S.pneumoniae R6 = spr0554; identified by match to protein family HMM PF02557; hypothetical protein 561970 4441275 SPD_0549 Streptococcus pneumoniae D39 hypothetical protein YP_816050.1 561254 D 373153 CDS YP_816051.1 116515716 4442253 562279..562704 1 NC_008533.1 binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 562704 rplK 4442253 rplK Streptococcus pneumoniae D39 50S ribosomal protein L11 YP_816051.1 562279 D 373153 CDS YP_816052.1 116515704 4441446 562912..563601 1 NC_008533.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 563601 rplA 4441446 rplA Streptococcus pneumoniae D39 50S ribosomal protein L1 YP_816052.1 562912 D 373153 CDS YP_816053.1 116515836 4441128 complement(564193..564780) 1 NC_008533.1 hypothetical protein 564780 4441128 SPD_0552 Streptococcus pneumoniae D39 hypothetical protein YP_816053.1 564193 R 373153 CDS YP_816054.1 116516994 4441976 564746..565075 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0633; hypothetical protein 565075 4441976 SPD_0553 Streptococcus pneumoniae D39 hypothetical protein YP_816054.1 564746 D 373153 CDS YP_816055.1 116516037 4441697 566119..567111 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0636; equivalent gene in S.pneumoniae R6 = spr0557; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 567111 4441697 SPD_0554 Streptococcus pneumoniae D39 ABC transporter ATP-binding protein YP_816055.1 566119 D 373153 CDS YP_816056.1 116516264 4441774 567113..567931 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0637; equivalent gene in S.pneumoniae R6 = spr0558; identified by match to protein family HMM PF06182; hypothetical protein 567931 4441774 SPD_0555 Streptococcus pneumoniae D39 hypothetical protein YP_816056.1 567113 D 373153 CDS YP_816057.1 116516906 4442053 567933..568718 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0638; equivalent gene in S.pneumoniae R6 = spr0559; identified by match to protein family HMM PF06182; hypothetical protein 568718 4442053 SPD_0556 Streptococcus pneumoniae D39 hypothetical protein YP_816057.1 567933 D 373153 CDS YP_816058.1 116516972 4442925 569948..576382 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0641; equivalent gene in S.pneumoniae R6 = spr0561; identified by match to protein family HMM PF00082; match to protein family HMM PF00746; match to protein family HMM PF02225; match to protein family HMM PF06280; match to protein family HMM TIGR01167; cell wall-associated serine protease PrtA 576382 prtA 4442925 prtA Streptococcus pneumoniae D39 cell wall-associated serine protease PrtA YP_816058.1 569948 D 373153 CDS YP_816059.1 116516145 4442507 577007..577483 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0645; equivalent gene in S.pneumoniae R6 = spr0562; identified by match to protein family HMM PF00359; PTS system transporter subunit IIA 577483 4442507 SPD_0559 Streptococcus pneumoniae D39 PTS system transporter subunit IIA YP_816059.1 577007 D 373153 CDS YP_816060.1 116516148 4442510 577521..577826 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0646; equivalent gene in S.pneumoniae R6 = spr0563; PTS system transporter subunit IIB 577826 4442510 SPD_0560 Streptococcus pneumoniae D39 PTS system transporter subunit IIB YP_816060.1 577521 D 373153 CDS YP_816061.1 116517184 4441821 577874..579349 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0647; equivalent gene in S.pneumoniae R6 = spr0564; identified by match to protein family HMM PF03611; PTS system transporter subunit IIC 579349 4441821 SPD_0561 Streptococcus pneumoniae D39 PTS system transporter subunit IIC YP_816061.1 577874 D 373153 CDS YP_816062.1 116515472 4442642 579654..586340 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0648; equivalent gene in S.pneumoniae R6 = spr0565; identified by match to protein family HMM PF00703; match to protein family HMM PF00746; match to protein family HMM PF02836; match to protein family HMM PF02837; match to protein family HMM PF04650; match to protein family HMM PF07501; match to protein family HMM PF07532; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; beta-galactosidase 586340 bgaA 4442642 bgaA Streptococcus pneumoniae D39 beta-galactosidase YP_816062.1 579654 D 373153 CDS YP_816063.1 116516317 4442800 complement(587654..588007) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0650; equivalent gene in S.pneumoniae R6 = spr0568; hypothetical protein 588007 4442800 SPD_0564 Streptococcus pneumoniae D39 hypothetical protein YP_816063.1 587654 R 373153 CDS YP_816064.1 116515520 4443001 588105..588557 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0569; hypothetical protein 588557 4443001 SPD_0565 Streptococcus pneumoniae D39 hypothetical protein YP_816064.1 588105 D 373153 CDS YP_816065.1 116517049 4441937 588615..589061 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0570; hypothetical protein 589061 4441937 SPD_0566 Streptococcus pneumoniae D39 hypothetical protein YP_816065.1 588615 D 373153 CDS YP_816066.1 116516252 4441762 589039..589602 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0652; equivalent gene in S.pneumoniae R6 = spr0571; identified by match to protein family HMM PF06962; hypothetical protein 589602 4441762 SPD_0567 Streptococcus pneumoniae D39 hypothetical protein YP_816066.1 589039 D 373153 CDS YP_816067.1 116516269 4441779 589595..589849 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0653; equivalent gene in S.pneumoniae R6 = spr0572; hypothetical protein 589849 4441779 SPD_0568 Streptococcus pneumoniae D39 hypothetical protein YP_816067.1 589595 D 373153 CDS YP_816068.1 116516836 4442155 589861..591915 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0655; equivalent gene in S.pneumoniae R6 = spr0573; identified by match to protein family HMM PF00999; sodium/hydrogen exchanger family protein 591915 4442155 SPD_0569 Streptococcus pneumoniae D39 sodium/hydrogen exchanger family protein YP_816068.1 589861 D 373153 CDS YP_816069.1 116516563 4441268 592094..592954 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0657; equivalent gene in S.pneumoniae R6 = spr0574; identified by match to protein family HMM PF03631; ribonuclease BN 592954 4441268 SPD_0570 Streptococcus pneumoniae D39 ribonuclease BN YP_816069.1 592094 D 373153 CDS YP_816070.1 116515707 4441449 593165..593875 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0658; equivalent gene in S.pneumoniae R6 = spr0575; identified by match to protein family HMM PF02683; cytochrome c-type biogenesis protein CcdA 593875 ccdA-1 4441449 ccdA-1 Streptococcus pneumoniae D39 cytochrome c-type biogenesis protein CcdA YP_816070.1 593165 D 373153 CDS YP_816071.1 116517064 4441952 593895..594461 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0659; equivalent gene in S.pneumoniae R6 = spr0576; thioredoxin family protein 594461 4441952 SPD_0572 Streptococcus pneumoniae D39 thioredoxin family protein YP_816071.1 593895 D 373153 CDS YP_816072.1 116515600 4442739 594649..595584 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0660; equivalent gene in S.pneumoniae R6 = spr0577; identified by match to protein family HMM PF01625; match to protein family HMM PF01641; match to protein family HMM TIGR00357; match to protein family HMM TIGR00401; bifunctional methionine sulfoxide reductase A/B 595584 msrAB2 4442739 msrAB2 Streptococcus pneumoniae D39 bifunctional methionine sulfoxide reductase A/B YP_816072.1 594649 D 373153 CDS YP_816073.1 116516390 4441596 595852..596589 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0661; equivalent gene in S.pneumoniae R6 = spr0578; identified by match to protein family HMM PF00072; match to protein family HMM PF00165; DNA-binding response regulator 596589 4441596 SPD_0574 Streptococcus pneumoniae D39 DNA-binding response regulator YP_816073.1 595852 D 373153 CDS YP_816074.1 116515466 4442636 596586..598277 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0662; equivalent gene in S.pneumoniae R6 = spr0579; identified by match to protein family HMM PF00672; match to protein family HMM PF02518; match to protein family HMM PF02743; match to protein family HMM PF06580; sensor histidine kinase 598277 4442636 SPD_0575 Streptococcus pneumoniae D39 sensor histidine kinase YP_816074.1 596586 D 373153 CDS YP_816075.1 116516627 4441415 598393..598956 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0663; equivalent gene in S.pneumoniae R6 = spr0580; identified by match to protein family HMM PF04260; match to protein family HMM TIGR01440; hypothetical protein 598956 4441415 SPD_0576 Streptococcus pneumoniae D39 hypothetical protein YP_816075.1 598393 D 373153 CDS YP_816076.1 116515780 4441680 598978..604608 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0581; identified by match to protein family HMM PF00746; match to protein family HMM PF05342; match to protein family HMM PF07501; match to protein family HMM PF07580; match to protein family HMM TIGR01167; zinc metalloprotease ZmpB 604608 zmpB 4441680 zmpB Streptococcus pneumoniae D39 zinc metalloprotease ZmpB YP_816076.1 598978 D 373153 CDS YP_816077.1 116516803 4442198 604678..606399 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0665; equivalent gene in S.pneumoniae R6 = spr0582; identified by match to protein family HMM PF00425; match to protein family HMM TIGR00553; para-aminobenzoate synthase, component I 606399 pabB 4442198 pabB Streptococcus pneumoniae D39 para-aminobenzoate synthase, component I YP_816077.1 604678 D 373153 CDS YP_816078.1 116516626 4441414 606557..607546 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0667; equivalent gene in S.pneumoniae R6 = spr0583; identified by match to protein family HMM PF01473; match to protein family HMM PF05901; match to protein family HMM PF07553; surface protein 607546 4441414 SPD_0579 Streptococcus pneumoniae D39 surface protein YP_816078.1 606557 D 373153 CDS YP_816079.1 116517028 4441973 607682..608641 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0668; equivalent gene in S.pneumoniae R6 = spr0584; identified by match to protein family HMM PF00480; match to protein family HMM TIGR00744; glucokinase 608641 gki 4441973 gki Streptococcus pneumoniae D39 glucokinase YP_816079.1 607682 D 373153 CDS YP_816080.1 116516193 4441151 608738..609577 1 NC_008533.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase 609577 thyA 4441151 thyA Streptococcus pneumoniae D39 thymidylate synthase YP_816080.1 608738 D 373153 CDS YP_816081.1 116516058 4442767 complement(609625..609795) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0670; equivalent gene in S.pneumoniae R6 = spr0586; hypothetical protein 609795 4442767 SPD_0582 Streptococcus pneumoniae D39 hypothetical protein YP_816081.1 609625 R 373153 CDS YP_816082.1 116515353 4441153 609916..610800 1 NC_008533.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 610800 miaA 4441153 miaA Streptococcus pneumoniae D39 tRNA delta(2)-isopentenylpyrophosphate transferase YP_816082.1 609916 D 373153 CDS YP_816083.1 116517076 4441926 610793..612031 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0672; equivalent gene in S.pneumoniae R6 = spr0589; identified by match to protein family HMM PF01926; match to protein family HMM TIGR00231; GTP-binding protein HflX 612031 hflX 4441926 hflX Streptococcus pneumoniae D39 GTP-binding protein HflX YP_816083.1 610793 D 373153 CDS YP_816084.1 116516854 4442135 612024..612647 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0673; equivalent gene in S.pneumoniae R6 = spr0590; hypothetical protein 612647 4442135 SPD_0585 Streptococcus pneumoniae D39 hypothetical protein YP_816084.1 612024 D 373153 CDS YP_816085.1 116516699 4442325 612662..613591 1 NC_008533.1 member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions; ribonuclease Z 613591 rnz 4442325 rnz Streptococcus pneumoniae D39 ribonuclease Z YP_816085.1 612662 D 373153 CDS YP_816086.1 116515980 4442431 613612..614367 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0675; equivalent gene in S.pneumoniae R6 = spr0592; identified by match to protein family HMM PF00106; short chain dehydrogenase/reductase family oxidoreductase 614367 4442431 SPD_0587 Streptococcus pneumoniae D39 short chain dehydrogenase/reductase family oxidoreductase YP_816086.1 613612 D 373153 CDS YP_816087.1 116517096 4441907 complement(614421..615389) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0676; equivalent gene in S.pneumoniae R6 = spr0593; identified by match to protein family HMM PF00126; transcriptional regulator 615389 4441907 SPD_0588 Streptococcus pneumoniae D39 transcriptional regulator YP_816087.1 614421 R 373153 CDS YP_816088.1 116516426 4441652 615393..615662 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0677; equivalent gene in S.pneumoniae R6 = spr0594; identified by match to protein family HMM PF06014; hypothetical protein 615662 4441652 SPD_0589 Streptococcus pneumoniae D39 hypothetical protein YP_816088.1 615393 D 373153 CDS YP_816089.1 116515527 4442891 615662..616042 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0678; equivalent gene in S.pneumoniae R6 = spr0595; identified by match to protein family HMM PF00581; rhodanese-like domain-containing protein 616042 4442891 SPD_0590 Streptococcus pneumoniae D39 rhodanese-like domain-containing protein YP_816089.1 615662 D 373153 CDS YP_816090.1 116517051 4441939 616161..616358 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0679; equivalent gene in S.pneumoniae R6 = spr0596; hypothetical protein 616358 4441939 SPD_0591 Streptococcus pneumoniae D39 hypothetical protein YP_816090.1 616161 D 373153 CDS YP_816091.1 116516226 4441486 complement(616398..617123) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0680; equivalent gene in S.pneumoniae R6 = spr0597; identified by match to protein family HMM PF00849; match to protein family HMM PF01479; match to protein family HMM TIGR00093; ribosomal small subunit pseudouridine synthase A 617123 rsuA-2 4441486 rsuA-2 Streptococcus pneumoniae D39 ribosomal small subunit pseudouridine synthase A YP_816091.1 616398 R 373153 CDS YP_816092.1 116516567 4441272 617285..619126 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0681; equivalent gene in S.pneumoniae R6 = spr0598; identified by match to protein family HMM PF00009; match to protein family HMM PF00679; match to protein family HMM PF03144; match to protein family HMM TIGR00231; match to protein family HMM TIGR01394; elongation factor Tu family protein 619126 4441272 SPD_0593 Streptococcus pneumoniae D39 elongation factor Tu family protein YP_816092.1 617285 D 373153 CDS YP_816093.1 116515475 4442645 619146..619400 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0682; equivalent gene in S.pneumoniae R6 = spr0599; hypothetical protein 619400 4442645 SPD_0594 Streptococcus pneumoniae D39 hypothetical protein YP_816093.1 619146 D 373153 CDS YP_816094.1 116516306 4442595 619716..620063 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0600; identified by match to protein family HMM TIGR01653; hypothetical protein 620063 4442595 SPD_0595 Streptococcus pneumoniae D39 hypothetical protein YP_816094.1 619716 D 373153 CDS YP_816095.1 116515430 4441277 620134..622155 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0686; equivalent gene in S.pneumoniae R6 = spr0601; identified by match to protein family HMM PF07242; match to protein family HMM TIGR01654; hypothetical protein 622155 4441277 SPD_0596 Streptococcus pneumoniae D39 hypothetical protein YP_816095.1 620134 D 373153 CDS YP_816096.1 116516538 4441041 622157..622798 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0687; equivalent gene in S.pneumoniae R6 = spr0602; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 622798 4441041 SPD_0597 Streptococcus pneumoniae D39 ABC transporter ATP-binding protein YP_816096.1 622157 D 373153 CDS YP_816097.1 116515762 4442418 622902..624254 1 NC_008533.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 624254 murD 4442418 murD Streptococcus pneumoniae D39 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase YP_816097.1 622902 D 373153 CDS YP_816098.1 116515971 4442422 624258..625316 1 NC_008533.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 625316 murG 4442422 murG Streptococcus pneumoniae D39 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase YP_816098.1 624258 D 373153 CDS YP_816099.1 116517041 4442355 625326..626516 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0690; equivalent gene in S.pneumoniae R6 = spr0605; identified by match to protein family HMM PF03799; cell division protein DivIB 626516 divIB 4442355 divIB Streptococcus pneumoniae D39 cell division protein DivIB YP_816099.1 625326 D 373153 CDS YP_816100.1 116516346 4442948 626647..626772 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0691; identified by Glimmer2; hypothetical protein 626772 4442948 SPD_0601 Streptococcus pneumoniae D39 hypothetical protein YP_816100.1 626647 D 373153 CDS YP_816101.1 116515555 4442729 626784..626915 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0692; hypothetical protein 626915 4442729 SPD_0602 Streptococcus pneumoniae D39 hypothetical protein YP_816101.1 626784 D 373153 CDS YP_816102.1 116517120 4441892 627307..628104 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0694; equivalent gene in S.pneumoniae R6 = spr0607; identified by match to protein family HMM PF02163; hypothetical protein 628104 4441892 SPD_0603 Streptococcus pneumoniae D39 hypothetical protein YP_816102.1 627307 D 373153 CDS YP_816103.1 116516052 4442761 628447..629460 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0695; equivalent gene in S.pneumoniae R6 = spr0608; identified by match to protein family HMM PF00899; HesA/MoeB/ThiF family protein 629460 4442761 SPD_0604 Streptococcus pneumoniae D39 HesA/MoeB/ThiF family protein YP_816103.1 628447 D 373153 CDS YP_816104.1 116515841 4441532 630496..631209 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0698; equivalent gene in S.pneumoniae R6 = spr0611; identified by match to protein family HMM PF01061; hypothetical protein 631209 4441532 SPD_0606 Streptococcus pneumoniae D39 hypothetical protein YP_816104.1 630496 D 373153 CDS YP_816105.1 116516349 4442951 631944..632645 1 NC_008533.1 type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 632645 pyrF 4442951 pyrF Streptococcus pneumoniae D39 orotidine 5'-phosphate decarboxylase YP_816105.1 631944 D 373153 CDS YP_816106.1 116515534 4442899 632679..633311 1 NC_008533.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 633311 pyrE 4442899 pyrE Streptococcus pneumoniae D39 orotate phosphoribosyltransferase YP_816106.1 632679 D 373153 CDS YP_816107.1 116516064 4442519 633491..633895 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0703; equivalent gene in S.pneumoniae R6 = spr0615; hypothetical protein 633895 4442519 SPD_0610 Streptococcus pneumoniae D39 hypothetical protein YP_816107.1 633491 D 373153 CDS YP_816108.1 116517221 4441789 633991..634755 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0704; equivalent gene in S.pneumoniae R6 = spr0616; hypothetical protein 634755 4441789 SPD_0611 Streptococcus pneumoniae D39 hypothetical protein YP_816108.1 633991 D 373153 CDS YP_816109.1 116517024 4441969 634755..635507 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0705; equivalent gene in S.pneumoniae R6 = spr0617; hypothetical protein 635507 4441969 SPD_0612 Streptococcus pneumoniae D39 hypothetical protein YP_816109.1 634755 D 373153 CDS YP_816110.1 116515954 4441395 635511..636215 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0706; equivalent gene in S.pneumoniae R6 = spr0618; hypothetical protein 636215 4441395 SPD_0613 Streptococcus pneumoniae D39 hypothetical protein YP_816110.1 635511 D 373153 CDS YP_816111.1 116516384 4441589 636212..636859 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0707; equivalent gene in S.pneumoniae R6 = spr0619; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 636859 4441589 SPD_0614 Streptococcus pneumoniae D39 ABC transporter ATP-binding protein YP_816111.1 636212 D 373153 CDS YP_816112.1 116515352 4441152 complement(637816..638574) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0709; equivalent gene in S.pneumoniae R6 = spr0622; identified by match to protein family HMM PF00005; amino acid ABC transporter ATP-binding protein 638574 4441152 SPD_0616 Streptococcus pneumoniae D39 amino acid ABC transporter ATP-binding protein YP_816112.1 637816 R 373153 CDS YP_816113.1 116516015 4441577 complement(638575..639252) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0710; equivalent gene in S.pneumoniae R6 = spr0623; identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; amino acid ABC transporter permease 639252 4441577 SPD_0617 Streptococcus pneumoniae D39 amino acid ABC transporter permease YP_816113.1 638575 R 373153 CDS YP_816114.1 116516616 4442394 complement(639212..639892) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0711; equivalent gene in S.pneumoniae R6 = spr0624; identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; amino acid ABC transporter permease 639892 4442394 SPD_0618 Streptococcus pneumoniae D39 amino acid ABC transporter permease YP_816114.1 639212 R 373153 CDS YP_816115.1 116515805 4442852 640107..640253 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0712; equivalent gene in S.pneumoniae R6 = spr0625; hypothetical protein 640253 4442852 SPD_0619 Streptococcus pneumoniae D39 hypothetical protein YP_816115.1 640107 D 373153 CDS YP_816116.1 116517090 4441901 640381..641871 1 NC_008533.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 641871 lysS 4441901 lysS Streptococcus pneumoniae D39 lysyl-tRNA synthetase YP_816116.1 640381 D 373153 CDS YP_816117.1 116517149 4441863 642496..643632 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0715; equivalent gene in S.pneumoniae R6 = spr0627; identified by match to protein family HMM PF01070; match to protein family HMM TIGR02708; lactate oxidase 643632 lctO 4441863 lctO Streptococcus pneumoniae D39 lactate oxidase YP_816117.1 642496 D 373153 CDS YP_816118.1 116516305 4442594 644187..644855 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0716; equivalent gene in S.pneumoniae R6 = spr0628; identified by match to protein family HMM PF03070; transcriptional regulator, TENA/THI-4 family protein 644855 4442594 SPD_0622 Streptococcus pneumoniae D39 transcriptional regulator, TENA/THI-4 family protein YP_816118.1 644187 D 373153 CDS YP_816119.1 116515661 4441244 645144..645926 1 NC_008533.1 catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP; hydroxyethylthiazole kinase 645926 thiM 4441244 thiM Streptococcus pneumoniae D39 hydroxyethylthiazole kinase YP_816119.1 645144 D 373153 CDS YP_816120.1 116516536 4441039 645928..646557 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0718; equivalent gene in S.pneumoniae R6 = spr0630; identified by match to protein family HMM PF02581; match to protein family HMM TIGR00693; thiamine-phosphate pyrophosphorylase 646557 thiE-1 4441039 thiE-1 Streptococcus pneumoniae D39 thiamine-phosphate pyrophosphorylase YP_816120.1 645928 D 373153 CDS YP_816121.1 116516079 4442536 647115..647675 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0719; equivalent gene in S.pneumoniae R6 = spr0631; hypothetical protein 647675 4442536 SPD_0625 Streptococcus pneumoniae D39 hypothetical protein YP_816121.1 647115 D 373153 CDS YP_816122.1 116516786 4442239 647676..649061 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0720; equivalent gene in S.pneumoniae R6 = spr0632; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 649061 4442239 SPD_0626 Streptococcus pneumoniae D39 ABC transporter ATP-binding protein YP_816122.1 647676 D 373153 CDS YP_816123.1 116516329 4442812 649063..649713 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0721; equivalent gene in S.pneumoniae R6 = spr0633; hypothetical protein 649713 4442812 SPD_0627 Streptococcus pneumoniae D39 hypothetical protein YP_816123.1 649063 D 373153 CDS YP_816124.1 116517113 4441885 649724..650416 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0722; equivalent gene in S.pneumoniae R6 = spr0634; identified by match to protein family HMM PF03070; transcriptional activator TenA, TENA/THI-4 family protein 650416 tenA 4441885 tenA Streptococcus pneumoniae D39 transcriptional activator TenA, TENA/THI-4 family protein YP_816124.1 649724 D 373153 CDS YP_816125.1 116516704 4442330 650421..650945 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0723; equivalent gene in S.pneumoniae R6 = spr0635; identified by match to protein family HMM TIGR02359; hypothetical protein 650945 thiW 4442330 thiW Streptococcus pneumoniae D39 hypothetical protein YP_816125.1 650421 D 373153 CDS YP_816126.1 116515654 4441237 650945..651748 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0724; equivalent gene in S.pneumoniae R6 = spr0636; identified by match to protein family HMM PF02110; hydroxyethylthiazole kinase 651748 4441237 SPD_0630 Streptococcus pneumoniae D39 hydroxyethylthiazole kinase YP_816126.1 650945 D 373153 CDS YP_816127.1 116515649 4441329 651741..652373 1 NC_008533.1 Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate; thiamine-phosphate pyrophosphorylase 652373 thiE 4441329 thiE Streptococcus pneumoniae D39 thiamine-phosphate pyrophosphorylase YP_816127.1 651741 D 373153 CDS YP_816128.1 116516553 4441258 complement(652582..653373) 1 NC_008533.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase 653373 thiD 4441258 thiD Streptococcus pneumoniae D39 phosphomethylpyrimidine kinase YP_816128.1 652582 R 373153 CDS YP_816129.1 116515476 4442646 653739..654134 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0727; equivalent gene in S.pneumoniae R6 = spr0639; identified by match to protein family HMM PF03965; match to protein family HMM TIGR02698; transcriptional regulator 654134 4442646 SPD_0633 Streptococcus pneumoniae D39 transcriptional regulator YP_816129.1 653739 D 373153 CDS YP_816130.1 116516327 4442810 654145..654516 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0728; equivalent gene in S.pneumoniae R6 = spr0640; hypothetical protein 654516 4442810 SPD_0634 Streptococcus pneumoniae D39 hypothetical protein YP_816130.1 654145 D 373153 CDS YP_816131.1 116517177 4441853 654526..656769 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0729; equivalent gene in S.pneumoniae R6 = spr0641; identified by match to protein family HMM PF00122; match to protein family HMM PF00702; match to protein family HMM TIGR01494; match to protein family HMM TIGR01511; match to protein family HMM TIGR01525; cation-transporting ATPase, E1-E2 family protein 656769 4441853 SPD_0635 Streptococcus pneumoniae D39 cation-transporting ATPase, E1-E2 family protein YP_816131.1 654526 D 373153 CDS YP_816132.1 116516119 4441644 656976..658751 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0730; equivalent gene in S.pneumoniae R6 = spr0642; identified by match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; match to protein family HMM TIGR02720; pyruvate oxidase 658751 spxB 4441644 spxB Streptococcus pneumoniae D39 pyruvate oxidase YP_816132.1 656976 D 373153 CDS YP_816133.1 116517078 4441928 658862..659209 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0731; equivalent gene in S.pneumoniae R6 = spr0643; identified by match to protein family HMM PF00903; hypothetical protein 659209 4441928 SPD_0637 Streptococcus pneumoniae D39 hypothetical protein YP_816133.1 658862 D 373153 CDS YP_816134.1 116516202 4441462 complement(659326..659979) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0811; equivalent gene in S.pneumoniae R6 = spr0644; transposase family protein 659979 4441462 SPD_0638 Streptococcus pneumoniae D39 transposase family protein YP_816134.1 659326 R 373153 CDS YP_816135.1 116516778 4442231 complement(659867..660214) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1487; equivalent gene in S.pneumoniae R6 = spr0645; hypothetical protein 660214 4442231 SPD_0639 Streptococcus pneumoniae D39 hypothetical protein YP_816135.1 659867 R 373153 CDS YP_816136.1 116516277 4442605 661064..662008 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0736; equivalent gene in S.pneumoniae R6 = spr0647; identified by match to protein family HMM PF01238; match to protein family HMM TIGR00218; mannose-6-phosphate isomerase 662008 manA 4442605 manA Streptococcus pneumoniae D39 mannose-6-phosphate isomerase YP_816136.1 661064 D 373153 CDS YP_816137.1 116515423 4442493 complement(662111..663496) 1 NC_008533.1 This gene may encode a frameshift. The COOH end is frameshifted relative to the TIGR4 ortholog. equivalent gene in S.pneumoniae TIGR4 = SP0737; equivalent gene in S.pneumoniae R6 = spr0648; identified by match to protein family HMM PF00209; sodium-dependent transporter 663496 4442493 SPD_0642 Streptococcus pneumoniae D39 sodium-dependent transporter YP_816137.1 662111 R 373153 CDS YP_816138.1 116515491 4441301 complement(664353..664808) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0740; equivalent gene in S.pneumoniae R6 = spr0650; identified by match to protein family HMM PF00293; MutT/nudix family protein 664808 4441301 SPD_0644 Streptococcus pneumoniae D39 MutT/nudix family protein YP_816138.1 664353 R 373153 CDS YP_816139.1 116516881 4442124 complement(664828..666003) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0741; equivalent gene in S.pneumoniae R6 = spr0651; identified by match to protein family HMM PF03486; match to protein family HMM TIGR00275; hypothetical protein 666003 4442124 SPD_0645 Streptococcus pneumoniae D39 hypothetical protein YP_816139.1 664828 R 373153 CDS YP_816140.1 116516904 4442089 complement(666062..666907) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0742; equivalent gene in S.pneumoniae R6 = spr0652; identified by match to protein family HMM PF02645; hypothetical protein 666907 4442089 SPD_0646 Streptococcus pneumoniae D39 hypothetical protein YP_816140.1 666062 R 373153 CDS YP_816141.1 116517044 4442358 667032..667589 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0743; equivalent gene in S.pneumoniae R6 = spr0653; identified by match to protein family HMM PF00440; transcriptional regulator, TetR family protein 667589 4442358 SPD_0647 Streptococcus pneumoniae D39 transcriptional regulator, TetR family protein YP_816141.1 667032 D 373153 CDS YP_816142.1 116515918 4441061 667608..668075 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0744; equivalent gene in S.pneumoniae R6 = spr0654; identified by match to protein family HMM PF00383; cytidine and deoxycytidylate deaminase family protein 668075 4441061 SPD_0648 Streptococcus pneumoniae D39 cytidine and deoxycytidylate deaminase family protein YP_816142.1 667608 D 373153 CDS YP_816143.1 116515358 4441158 668143..668793 1 NC_008533.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 668793 upp 4441158 upp Streptococcus pneumoniae D39 uracil phosphoribosyltransferase YP_816143.1 668143 D 373153 CDS YP_816144.1 116516216 4441476 668967..669557 1 NC_008533.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 669557 clpP 4441476 clpP Streptococcus pneumoniae D39 ATP-dependent Clp protease proteolytic subunit YP_816144.1 668967 D 373153 CDS YP_816145.1 116516631 4441420 669636..669884 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0748; equivalent gene in S.pneumoniae R6 = spr0657; hypothetical protein 669884 4441420 SPD_0651 Streptococcus pneumoniae D39 hypothetical protein YP_816145.1 669636 D 373153 CDS YP_816146.1 116515756 4442411 669986..671146 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0749; equivalent gene in S.pneumoniae R6 = spr0659; identified by match to protein family HMM PF01094; branched-chain amino acid ABC transporter substrate-binding protein 671146 livJ 4442411 livJ Streptococcus pneumoniae D39 branched-chain amino acid ABC transporter substrate-binding protein YP_816146.1 669986 D 373153 CDS YP_816147.1 116515326 4442669 671414..672283 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0750; equivalent gene in S.pneumoniae R6 = spr0660; identified by match to protein family HMM PF02653; branched-chain amino acid ABC transporter permease 672283 livH 4442669 livH Streptococcus pneumoniae D39 branched-chain amino acid ABC transporter permease YP_816147.1 671414 D 373153 CDS YP_816148.1 116516639 4441428 672287..673243 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0751; equivalent gene in S.pneumoniae R6 = spr0661; identified by match to protein family HMM PF02653; branched-chain amino acid ABC transporter permease 673243 livM 4441428 livM Streptococcus pneumoniae D39 branched-chain amino acid ABC transporter permease YP_816148.1 672287 D 373153 CDS YP_816149.1 116516236 4441516 673243..674007 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0752; equivalent gene in S.pneumoniae R6 = spr0662; identified by match to protein family HMM PF00005; branched-chain amino acid ABC transporter ATP-binding protein 674007 livG 4441516 livG Streptococcus pneumoniae D39 branched-chain amino acid ABC transporter ATP-binding protein YP_816149.1 673243 D 373153 CDS YP_816150.1 116516439 4442558 674007..674717 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0753; equivalent gene in S.pneumoniae R6 = spr0663; identified by match to protein family HMM PF00005; branched-chain amino acid ABC transporter ATP-binding protein 674717 livF 4442558 livF Streptococcus pneumoniae D39 branched-chain amino acid ABC transporter ATP-binding protein YP_816150.1 674007 D 373153 CDS YP_816151.1 116516866 4442148 675131..675787 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0754; equivalent gene in S.pneumoniae R6 = spr0664; identified by match to protein family HMM PF00571; match to protein family HMM PF01842; acetoin utilization protein AcuB 675787 4442148 SPD_0657 Streptococcus pneumoniae D39 acetoin utilization protein AcuB YP_816151.1 675131 D 373153 CDS YP_816152.1 116516272 4442600 676001..676990 1 NC_008533.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 676990 prfB 4442600 prfB Streptococcus pneumoniae D39 peptide chain release factor 2 YP_816152.1 676001 D 373153 CDS YP_816153.1 116515754 4442409 677008..677700 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0756; equivalent gene in S.pneumoniae R6 = spr0666; identified by match to protein family HMM PF00005; match to protein family HMM TIGR02673; cell division ATP-binding protein FtsE 677700 ftsE 4442409 ftsE Streptococcus pneumoniae D39 cell division ATP-binding protein FtsE YP_816153.1 677008 D 373153 CDS YP_816154.1 116516625 4441413 677693..678619 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0757; equivalent gene in S.pneumoniae R6 = spr0667; identified by match to protein family HMM PF02687; cell division ABC transporter permease FtsX 678619 ftsX 4441413 ftsX Streptococcus pneumoniae D39 cell division ABC transporter permease FtsX YP_816154.1 677693 D 373153 CDS YP_816155.1 116517154 4441868 678905..681085 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0758; equivalent gene in S.pneumoniae R6 = spr0668; identified by match to protein family HMM PF00358; match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826; match to protein family HMM TIGR00830; match to protein family HMM TIGR02003; PTS system transporter subunit IIABC 681085 exp5 4441868 exp5 Streptococcus pneumoniae D39 PTS system transporter subunit IIABC YP_816155.1 678905 D 373153 CDS YP_816156.1 116516071 4442527 681137..681952 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0760; equivalent gene in S.pneumoniae R6 = spr0669; identified by match to protein family HMM PF03372; hypothetical protein 681952 4442527 SPD_0662 Streptococcus pneumoniae D39 hypothetical protein YP_816156.1 681137 D 373153 CDS YP_816157.1 116516888 4442073 682092..683435 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0761; equivalent gene in S.pneumoniae R6 = spr0670; identified by match to protein family HMM PF00270; match to protein family HMM PF00271; ATP-dependent RNA helicase 683435 4442073 SPD_0663 Streptococcus pneumoniae D39 ATP-dependent RNA helicase YP_816157.1 682092 D 373153 CDS YP_816158.1 116515567 4442877 683650..684840 1 NC_008533.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 684840 metK 4442877 metK Streptococcus pneumoniae D39 S-adenosylmethionine synthetase YP_816158.1 683650 D 373153 CDS YP_816159.1 116516687 4441361 685393..686328 1 NC_008533.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; subclass 1A is a dimer formed by two identical PyrD subunits each containing an FMN group; dihydroorotate dehydrogenase 1A 686328 pyrDa 4441361 pyrDa Streptococcus pneumoniae D39 dihydroorotate dehydrogenase 1A YP_816159.1 685393 D 373153 CDS YP_816160.1 116515334 4441076 686362..687399 1 NC_008533.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta 687399 holA 4441076 holA Streptococcus pneumoniae D39 DNA polymerase III subunit delta YP_816160.1 686362 D 373153 CDS YP_816161.1 116515547 4442721 687572..688177 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0766; equivalent gene in S.pneumoniae R6 = spr0674; identified by match to protein family HMM PF00081; match to protein family HMM PF02777; superoxide dismutase, manganese-dependent 688177 sodA 4442721 sodA Streptococcus pneumoniae D39 superoxide dismutase, manganese-dependent YP_816161.1 687572 D 373153 CDS YP_816162.1 116516259 4441769 688334..688864 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0767; equivalent gene in S.pneumoniae R6 = spr0675; identified by match to protein family HMM PF06265; hypothetical protein 688864 4441769 SPD_0668 Streptococcus pneumoniae D39 hypothetical protein YP_816162.1 688334 D 373153 CDS YP_816163.1 116516867 4442149 688885..689970 1 NC_008533.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance; ribosomal RNA large subunit methyltransferase N 689970 4442149 SPD_0669 Streptococcus pneumoniae D39 ribosomal RNA large subunit methyltransferase N YP_816163.1 688885 D 373153 CDS YP_816164.1 116515988 4441491 690008..690439 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0677; identified by match to protein family HMM PF04892; hypothetical protein 690439 4441491 SPD_0670 Streptococcus pneumoniae D39 hypothetical protein YP_816164.1 690008 D 373153 CDS YP_816165.1 116516136 4442226 690441..691982 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0770; equivalent gene in S.pneumoniae R6 = spr0678; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 691982 4442226 SPD_0671 Streptococcus pneumoniae D39 ABC transporter ATP-binding protein YP_816165.1 690441 D 373153 CDS YP_816166.1 116516991 4442012 complement(692039..692842) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0771; equivalent gene in S.pneumoniae R6 = spr0679; identified by match to protein family HMM PF00160; cyclophilin type peptidyl-prolyl cis-trans isomerase 692842 4442012 SPD_0672 Streptococcus pneumoniae D39 cyclophilin type peptidyl-prolyl cis-trans isomerase YP_816166.1 692039 R 373153 CDS YP_816167.1 116516873 4442116 complement(692926..693147) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0772; equivalent gene in S.pneumoniae R6 = spr0680; hypothetical protein 693147 4442116 SPD_0673 Streptococcus pneumoniae D39 hypothetical protein YP_816167.1 692926 R 373153 CDS YP_816168.1 116516029 4441689 694013..694285 1 NC_008533.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 694285 rpsP 4441689 rpsP Streptococcus pneumoniae D39 30S ribosomal protein S16 YP_816168.1 694013 D 373153 CDS YP_816169.1 116515603 4442742 694305..694544 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0776; equivalent gene in S.pneumoniae R6 = spr0683; hypothetical protein 694544 4442742 SPD_0675 Streptococcus pneumoniae D39 hypothetical protein YP_816169.1 694305 D 373153 CDS YP_816170.1 116516691 4441365 695121..695549 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0777; equivalent gene in S.pneumoniae R6 = spr0684; hypothetical protein 695549 4441365 SPD_0676 Streptococcus pneumoniae D39 hypothetical protein YP_816170.1 695121 D 373153 CDS YP_816171.1 116516366 4443028 695550..695909 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0777; equivalent gene in S.pneumoniae R6 = spr0685; hypothetical protein 695909 4443028 SPD_0677 Streptococcus pneumoniae D39 hypothetical protein YP_816171.1 695550 D 373153 CDS YP_816172.1 116516249 4441529 695940..696458 1 NC_008533.1 Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 696458 rimM 4441529 rimM Streptococcus pneumoniae D39 16S rRNA-processing protein RimM YP_816172.1 695940 D 373153 CDS YP_816173.1 116516895 4442080 696448..697167 1 NC_008533.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 697167 trmD 4442080 trmD Streptococcus pneumoniae D39 tRNA (guanine-N(1)-)-methyltransferase YP_816173.1 696448 D 373153 CDS YP_816174.1 116515795 4441560 697179..697517 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0780; equivalent gene in S.pneumoniae R6 = spr0688; identified by match to protein family HMM PF03477; hypothetical protein 697517 4441560 SPD_0680 Streptococcus pneumoniae D39 hypothetical protein YP_816174.1 697179 D 373153 CDS YP_816175.1 116516822 4442179 complement(697548..697868) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0781; equivalent gene in S.pneumoniae R6 = spr0689; hypothetical protein 697868 4442179 SPD_0681 Streptococcus pneumoniae D39 hypothetical protein YP_816175.1 697548 R 373153 CDS YP_816176.1 116517047 4442362 697966..698181 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0782; equivalent gene in S.pneumoniae R6 = spr0690; hypothetical protein 698181 4442362 SPD_0683 Streptococcus pneumoniae D39 hypothetical protein YP_816176.1 697966 D 373153 CDS YP_816177.1 116516284 4442612 complement(698178..698324) 1 NC_008533.1 hypothetical protein 698324 4442612 SPD_0682 Streptococcus pneumoniae D39 hypothetical protein YP_816177.1 698178 R 373153 CDS YP_816178.1 116515429 4441276 complement(698385..698921) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0783; equivalent gene in S.pneumoniae R6 = spr0691; identified by match to protein family HMM PF02632; biotin synthase 698921 4441276 SPD_0684 Streptococcus pneumoniae D39 biotin synthase YP_816178.1 698385 R 373153 CDS YP_816179.1 116516716 4442342 complement(699118..700464) 1 NC_008533.1 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase 700464 gor 4442342 gor Streptococcus pneumoniae D39 glutathione reductase YP_816179.1 699118 R 373153 CDS YP_816180.1 116515711 4442248 700729..701928 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0785; equivalent gene in S.pneumoniae R6 = spr0693; identified by match to protein family HMM TIGR01730; hypothetical protein 701928 4442248 SPD_0686 Streptococcus pneumoniae D39 hypothetical protein YP_816180.1 700729 D 373153 CDS YP_816181.1 116515985 4442437 701912..702613 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0786; equivalent gene in S.pneumoniae R6 = spr0694; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 702613 4442437 SPD_0687 Streptococcus pneumoniae D39 ABC transporter ATP-binding protein YP_816181.1 701912 D 373153 CDS YP_816182.1 116516885 4442128 702615..703874 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0787; equivalent gene in S.pneumoniae R6 = spr0695; identified by match to protein family HMM PF02687; hypothetical protein 703874 4442128 SPD_0688 Streptococcus pneumoniae D39 hypothetical protein YP_816182.1 702615 D 373153 CDS YP_816183.1 116516229 4441489 703998..705995 1 NC_008533.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 705995 metG 4441489 metG Streptococcus pneumoniae D39 methionyl-tRNA synthetase YP_816183.1 703998 D 373153 CDS YP_816184.1 116517058 4441946 706045..706236 1 NC_008533.1 hypothetical protein 706236 4441946 SPD_0690 Streptococcus pneumoniae D39 hypothetical protein YP_816184.1 706045 D 373153 CDS YP_816185.1 116515400 4442470 706326..706646 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0789; equivalent gene in S.pneumoniae R6 = spr0697; identified by match to protein family HMM PF03551; hypothetical protein 706646 4442470 SPD_0691 Streptococcus pneumoniae D39 hypothetical protein YP_816185.1 706326 D 373153 CDS YP_816186.1 116516712 4442338 706650..707525 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0790; equivalent gene in S.pneumoniae R6 = spr0698; hypothetical protein 707525 4442338 SPD_0692 Streptococcus pneumoniae D39 hypothetical protein YP_816186.1 706650 D 373153 CDS YP_816187.1 116515786 4441551 707540..708466 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0791; equivalent gene in S.pneumoniae R6 = spr0699; identified by match to protein family HMM PF00248; oxidoreductase, aldo/keto reductase family protein 708466 4441551 SPD_0693 Streptococcus pneumoniae D39 oxidoreductase, aldo/keto reductase family protein YP_816187.1 707540 D 373153 CDS YP_816188.1 116516430 4441656 708545..708802 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0792; equivalent gene in S.pneumoniae R6 = spr0700; hypothetical protein 708802 4441656 SPD_0694 Streptococcus pneumoniae D39 hypothetical protein YP_816188.1 708545 D 373153 CDS YP_816189.1 116515543 4442717 708795..709493 1 NC_008533.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 709493 fabG 4442717 fabG Streptococcus pneumoniae D39 3-ketoacyl-ACP reductase YP_816189.1 708795 D 373153 CDS YP_816190.1 116516157 4442831 709504..709983 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0794; equivalent gene in S.pneumoniae R6 = spr0702; identified by match to protein family HMM PF00293; MutT/nudix family protein 709983 4442831 SPD_0696 Streptococcus pneumoniae D39 MutT/nudix family protein YP_816190.1 709504 D 373153 CDS YP_816191.1 116516788 4442241 709991..710719 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0703; identified by match to protein family HMM PF00583; GNAT family acetyltransferase 710719 4442241 SPD_0697 Streptococcus pneumoniae D39 GNAT family acetyltransferase YP_816191.1 709991 D 373153 CDS YP_816192.1 116515919 4441062 710761..711630 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0795; equivalent gene in S.pneumoniae R6 = spr0704; identified by match to protein family HMM PF02896; hypothetical protein 711630 4441062 SPD_0698 Streptococcus pneumoniae D39 hypothetical protein YP_816192.1 710761 D 373153 CDS YP_816193.1 116516645 4443049 711605..712045 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0796; equivalent gene in S.pneumoniae R6 = spr0705; identified by match to protein family HMM PF06171; hypothetical protein 712045 4443049 SPD_0699 Streptococcus pneumoniae D39 hypothetical protein YP_816193.1 711605 D 373153 CDS YP_816194.1 116515610 4442749 712168..714714 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0797; equivalent gene in S.pneumoniae R6 = spr0706; identified by match to protein family HMM PF01433; aminopeptidase N 714714 pepN 4442749 pepN Streptococcus pneumoniae D39 aminopeptidase N YP_816194.1 712168 D 373153 CDS YP_816195.1 116515465 4441190 714757..715497 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0798; equivalent gene in S.pneumoniae R6 = spr0707; identified by match to protein family HMM PF00072; match to protein family HMM PF00486; DNA-binding response regulator CiaR 715497 ciaR 4441190 ciaR Streptococcus pneumoniae D39 DNA-binding response regulator CiaR YP_816195.1 714757 D 373153 CDS YP_816196.1 116516689 4441363 715487..716821 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0799; equivalent gene in S.pneumoniae R6 = spr0708; identified by match to protein family HMM PF00512; match to protein family HMM PF02518; sensor histidine kinase CiaH 716821 ciaH 4441363 ciaH Streptococcus pneumoniae D39 sensor histidine kinase CiaH YP_816196.1 715487 D 373153 CDS YP_816197.1 116517218 4441816 complement(716855..717142) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0800; equivalent gene in S.pneumoniae R6 = spr0709; hypothetical protein 717142 4441816 SPD_0703 Streptococcus pneumoniae D39 hypothetical protein YP_816197.1 716855 R 373153 CDS YP_816198.1 116516394 4441601 717141..718211 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0801; equivalent gene in S.pneumoniae R6 = spr0710; identified by match to protein family HMM PF01136; hypothetical protein 718211 4441601 SPD_0704 Streptococcus pneumoniae D39 hypothetical protein YP_816198.1 717141 D 373153 CDS YP_816199.1 116516668 4442448 718411..720861 1 NC_008533.1 unwinds DNA; bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon 720861 4442448 SPD_0705 Streptococcus pneumoniae D39 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon YP_816199.1 718411 D 373153 CDS YP_816200.1 116515576 4442886 720898..722121 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0803; equivalent gene in S.pneumoniae R6 = spr0712; identified by match to protein family HMM PF01098; rod shape-determining protein RodA 722121 4442886 SPD_0706 Streptococcus pneumoniae D39 rod shape-determining protein RodA YP_816200.1 720898 D 373153 CDS YP_816201.1 116516953 4442031 722132..722686 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0804; equivalent gene in S.pneumoniae R6 = spr0713; identified by match to protein family HMM PF01965; match to protein family HMM TIGR01383; 4-methyl-5(b-hydroxyethyl)-thiazole monophosphate biosynthesis protein 722686 4442031 SPD_0707 Streptococcus pneumoniae D39 4-methyl-5(b-hydroxyethyl)-thiazole monophosphate biosynthesis protein YP_816201.1 722132 D 373153 CDS YP_816202.1 116515873 4441111 722771..723334 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0805; equivalent gene in S.pneumoniae R6 = spr0714; identified by match to protein family HMM PF00702; match to protein family HMM TIGR01549; hydrolase 723334 4441111 SPD_0708 Streptococcus pneumoniae D39 hydrolase YP_816202.1 722771 D 373153 CDS YP_816203.1 116516156 4442518 723349..725295 1 NC_008533.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 725295 gyrB 4442518 gyrB Streptococcus pneumoniae D39 DNA gyrase subunit B YP_816203.1 723349 D 373153 CDS YP_816204.1 116516893 4442078 725377..727104 1 NC_008533.1 acts to negatively regulates ftsZ ring formation by modulating the frequency and position of the ftsZ ring formation; septation ring formation regulator EzrA 727104 ezrA 4442078 ezrA Streptococcus pneumoniae D39 septation ring formation regulator EzrA YP_816204.1 725377 D 373153 CDS YP_816205.1 116515608 4442747 727898..728251 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1487; equivalent gene in S.pneumoniae R6 = spr0717; hypothetical protein 728251 4442747 SPD_0711 Streptococcus pneumoniae D39 hypothetical protein YP_816205.1 727898 D 373153 CDS YP_816206.1 116516414 4442980 728283..728792 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0811; equivalent gene in S.pneumoniae R6 = spr0718; transposase family protein 728792 4442980 SPD_0712 Streptococcus pneumoniae D39 transposase family protein YP_816206.1 728283 D 373153 CDS YP_816207.1 116515822 4441113 complement(729426..729725) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0816; equivalent gene in S.pneumoniae R6 = spr0720; hypothetical protein 729725 4441113 SPD_0714 Streptococcus pneumoniae D39 hypothetical protein YP_816207.1 729426 R 373153 CDS YP_816208.1 116515664 4441247 complement(729890..730312) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0817; equivalent gene in S.pneumoniae R6 = spr0721; identified by match to protein family HMM PF00293; MutT/nudix family protein 730312 4441247 SPD_0715 Streptococcus pneumoniae D39 MutT/nudix family protein YP_816208.1 729890 R 373153 CDS YP_816209.1 116517010 4441994 730405..730752 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0299; equivalent gene in S.pneumoniae R6 = spr0722 In TIGR4 this gene is annotated as a truncation; however in R6 there are numerous near perfect copies as well as copies with a slightly longer version with a different end that is not present in either R6 or TIGR4 This indicates it may still function as a transposase; identified by match to protein family HMM PF01710; IS630-Spn1, transposase Orf1 730752 4441994 SPD_0716 Streptococcus pneumoniae D39 IS630-Spn1, transposase Orf1 YP_816209.1 730405 D 373153 CDS YP_816210.1 116516310 4442793 complement(731477..733735) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0820; equivalent gene in S.pneumoniae R6 = spr0725; identified by match to protein family HMM PF00004; match to protein family HMM PF02151; match to protein family HMM PF07724; match to protein family HMM PF07728; ATP-dependent Clp protease ATP-binding subunit ClpE 733735 clpE 4442793 clpE Streptococcus pneumoniae D39 ATP-dependent Clp protease ATP-binding subunit ClpE YP_816210.1 731477 R 373153 CDS YP_816211.1 116515533 4442898 complement(733964..734194) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0822; equivalent gene in S.pneumoniae R6 = spr0726; hypothetical protein 734194 4442898 SPD_0718 Streptococcus pneumoniae D39 hypothetical protein YP_816211.1 733964 R 373153 CDS YP_816212.1 116516598 4441228 734384..735067 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0823; equivalent gene in S.pneumoniae R6 = spr0727; identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; amino acid ABC transporter permease 735067 4441228 SPD_0719 Streptococcus pneumoniae D39 amino acid ABC transporter permease YP_816212.1 734384 D 373153 CDS YP_816213.1 116515734 4441022 735067..735801 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0824; equivalent gene in S.pneumoniae R6 = spr0728; identified by match to protein family HMM PF00005; amino acid ABC transporter ATP-binding protein 735801 4441022 SPD_0720 Streptococcus pneumoniae D39 amino acid ABC transporter ATP-binding protein YP_816213.1 735067 D 373153 CDS YP_816214.1 116515868 4441104 735934..736812 1 NC_008533.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 736812 folD 4441104 folD Streptococcus pneumoniae D39 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase YP_816214.1 735934 D 373153 CDS YP_816215.1 116517034 4442348 736954..737826 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0730; identified by match to protein family HMM PF01256; match to protein family HMM TIGR00196; similar to the C-terminus of Escherichia coli YjeF; YjeF-like protein 737826 4442348 SPD_0722 Streptococcus pneumoniae D39 YjeF-like protein YP_816215.1 736954 D 373153 CDS YP_816216.1 116516446 4442565 738108..738791 1 NC_008533.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A 738791 rpiA 4442565 rpiA Streptococcus pneumoniae D39 ribose-5-phosphate isomerase A YP_816216.1 738108 D 373153 CDS YP_816217.1 116516348 4442950 738805..740016 1 NC_008533.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose; phosphopentomutase 740016 deoB 4442950 deoB Streptococcus pneumoniae D39 phosphopentomutase YP_816217.1 738805 D 373153 CDS YP_816218.1 116515467 4442637 740576..741385 1 NC_008533.1 catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation; purine nucleoside phosphorylase 741385 4442637 SPD_0726 Streptococcus pneumoniae D39 purine nucleoside phosphorylase YP_816218.1 740576 D 373153 CDS YP_816219.1 116516091 4442685 741861..742592 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0833; equivalent gene in S.pneumoniae R6 = spr0735; hypothetical protein 742592 4442685 SPD_0727 Streptococcus pneumoniae D39 hypothetical protein YP_816219.1 741861 D 373153 CDS YP_816220.1 116517195 4441832 742638..742841 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0833; equivalent gene in S.pneumoniae R6 = spr0736; hypothetical protein 742841 4441832 SPD_0728 Streptococcus pneumoniae D39 hypothetical protein YP_816220.1 742638 D 373153 CDS YP_816221.1 116516976 4441996 742866..743378 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0834; equivalent gene in S.pneumoniae R6 = spr0737; hemolysin-like protein 743378 4441996 SPD_0729 Streptococcus pneumoniae D39 hemolysin-like protein YP_816221.1 742866 D 373153 CDS YP_816222.1 116515621 4442701 744036..744746 1 NC_008533.1 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase 744746 deoD 4442701 deoD Streptococcus pneumoniae D39 purine nucleoside phosphorylase YP_816222.1 744036 D 373153 CDS YP_816223.1 116516744 4442294 complement(744769..745293) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0837; equivalent gene in S.pneumoniae R6 = spr0739; topology modulation protein 745293 4442294 SPD_0731 Streptococcus pneumoniae D39 topology modulation protein YP_816223.1 744769 R 373153 CDS YP_816224.1 116515680 4442546 complement(745346..745582) 1 NC_008533.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 745582 rpsT 4442546 rpsT Streptococcus pneumoniae D39 30S ribosomal protein S20 YP_816224.1 745346 R 373153 CDS YP_816225.1 116515774 4441674 complement(745650..746570) 1 NC_008533.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase 746570 coaA 4441674 coaA Streptococcus pneumoniae D39 pantothenate kinase YP_816225.1 745650 R 373153 CDS YP_816226.1 116516378 4443041 746768..747208 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0840; equivalent gene in S.pneumoniae R6 = spr0742; hypothetical protein 747208 4443041 SPD_0734 Streptococcus pneumoniae D39 hypothetical protein YP_816226.1 746768 D 373153 CDS YP_816227.1 116516099 4442693 747415..748005 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0841; equivalent gene in S.pneumoniae R6 = spr0743; identified by match to protein family HMM PF05175; methyltransferase small subunit 748005 4442693 SPD_0735 Streptococcus pneumoniae D39 methyltransferase small subunit YP_816227.1 747415 D 373153 CDS YP_816228.1 116516475 4442945 748002..749279 1 NC_008533.1 Catalyzes the reversible phosphorolysis of pyrimidines in the nucleotide synthesis salvage pathway; pyrimidine-nucleoside phosphorylase 749279 pdp 4442945 pdp Streptococcus pneumoniae D39 pyrimidine-nucleoside phosphorylase YP_816228.1 748002 D 373153 CDS YP_816229.1 116517157 4441871 749297..749959 1 NC_008533.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 749959 deoC 4441871 deoC Streptococcus pneumoniae D39 deoxyribose-phosphate aldolase YP_816229.1 749297 D 373153 CDS YP_816230.1 116516117 4441642 749946..750335 1 NC_008533.1 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 750335 cdd-1 4441642 cdd-1 Streptococcus pneumoniae D39 cytidine deaminase YP_816230.1 749946 D 373153 CDS YP_816231.1 116516951 4442029 750425..751477 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0845; equivalent gene in S.pneumoniae R6 = spr0747; identified by match to protein family HMM PF02608; membrane lipoprotein TmpC 751477 4442029 SPD_0739 Streptococcus pneumoniae D39 membrane lipoprotein TmpC YP_816231.1 750425 D 373153 CDS YP_816232.1 116515854 4441546 751621..753156 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0846; equivalent gene in S.pneumoniae R6 = spr0748; identified by match to protein family HMM PF00005; sugar ABC transporter ATP-binding protein 753156 4441546 SPD_0740 Streptococcus pneumoniae D39 sugar ABC transporter ATP-binding protein YP_816232.1 751621 D 373153 CDS YP_816233.1 116515653 4441236 753149..754207 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0847; equivalent gene in S.pneumoniae R6 = spr0749; identified by match to protein family HMM PF02653; sugar ABC transporter permease 754207 4441236 SPD_0741 Streptococcus pneumoniae D39 sugar ABC transporter permease YP_816233.1 753149 D 373153 CDS YP_816234.1 116516674 4442455 754210..755166 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0848; equivalent gene in S.pneumoniae R6 = spr0750; identified by match to protein family HMM PF02653; sugar ABC transporter permease 755166 4442455 SPD_0742 Streptococcus pneumoniae D39 sugar ABC transporter permease YP_816234.1 754210 D 373153 CDS YP_816235.1 116515637 4441317 complement(756641..757282) 1 NC_008533.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX; glycerol-3-phosphate acyltransferase PlsY 757282 4441317 SPD_0745 Streptococcus pneumoniae D39 glycerol-3-phosphate acyltransferase PlsY YP_816235.1 756641 R 373153 CDS YP_816236.1 116516535 4441038 757418..759361 1 NC_008533.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B 759361 parE 4441038 parE Streptococcus pneumoniae D39 DNA topoisomerase IV subunit B YP_816236.1 757418 D 373153 CDS YP_816237.1 116516296 4442585 759482..759607 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0854; hypothetical protein 759607 4442585 SPD_0747 Streptococcus pneumoniae D39 hypothetical protein YP_816237.1 759482 D 373153 CDS YP_816238.1 116515631 4442711 759772..762252 1 NC_008533.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A 762252 parC 4442711 parC Streptococcus pneumoniae D39 DNA topoisomerase IV subunit A YP_816238.1 759772 D 373153 CDS YP_816239.1 116516002 4441506 762382..763404 1 NC_008533.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 763404 ilvE 4441506 ilvE Streptococcus pneumoniae D39 branched-chain amino acid aminotransferase YP_816239.1 762382 D 373153 CDS YP_816240.1 116515710 4442247 763460..764164 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0759; hypothetical protein 764164 4442247 SPD_0750 Streptococcus pneumoniae D39 hypothetical protein YP_816240.1 763460 D 373153 CDS YP_816241.1 116516266 4441776 764229..764918 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0858; equivalent gene in S.pneumoniae R6 = spr0760; identified by match to protein family HMM PF06149; hypothetical protein 764918 4441776 SPD_0751 Streptococcus pneumoniae D39 hypothetical protein YP_816241.1 764229 D 373153 CDS YP_816242.1 116517099 4441910 764915..765838 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0859; equivalent gene in S.pneumoniae R6 = spr0761; identified by match to protein family HMM PF06166; hypothetical protein 765838 4441910 SPD_0752 Streptococcus pneumoniae D39 hypothetical protein YP_816242.1 764915 D 373153 CDS YP_816243.1 116515464 4441189 765853..766497 1 NC_008533.1 catalyzes the removal of 5-oxoproline from various penultimate amino acid residues except L-proline; pyrrolidone-carboxylate peptidase 766497 pcp 4441189 pcp Streptococcus pneumoniae D39 pyrrolidone-carboxylate peptidase YP_816243.1 765853 D 373153 CDS YP_816244.1 116516313 4442796 766665..766895 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0861; equivalent gene in S.pneumoniae R6 = spr0763; hypothetical protein 766895 4442796 SPD_0754 Streptococcus pneumoniae D39 hypothetical protein YP_816244.1 766665 D 373153 CDS YP_816245.1 116515525 4442889 767268..768470 1 NC_008533.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 768470 rpsA 4442889 rpsA Streptococcus pneumoniae D39 30S ribosomal protein S1 YP_816245.1 767268 D 373153 CDS YP_816246.1 116515639 4441319 770126..770623 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0864; equivalent gene in S.pneumoniae R6 = spr0768; hypothetical protein 770623 4441319 SPD_0759 Streptococcus pneumoniae D39 hypothetical protein YP_816246.1 770126 D 373153 CDS YP_816247.1 116516459 4442929 770623..772278 1 NC_008533.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 772278 dnaX 4442929 dnaX Streptococcus pneumoniae D39 DNA polymerase III subunits gamma and tau YP_816247.1 770623 D 373153 CDS YP_816248.1 116515381 4441617 772306..772500 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0866; equivalent gene in S.pneumoniae R6 = spr0770; hypothetical protein 772500 4441617 SPD_0761 Streptococcus pneumoniae D39 hypothetical protein YP_816248.1 772306 D 373153 CDS YP_816249.1 116517208 4441806 772650..773420 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0867; equivalent gene in S.pneumoniae R6 = spr0771; identified by match to protein family HMM PF00005; match to protein family HMM TIGR01978; FeS assembly ATPase SufC 773420 sufC 4441806 sufC Streptococcus pneumoniae D39 FeS assembly ATPase SufC YP_816249.1 772650 D 373153 CDS YP_816250.1 116516109 4441634 773448..774710 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0868; equivalent gene in S.pneumoniae R6 = spr0772; identified by match to protein family HMM PF01458; match to protein family HMM TIGR01981; hypothetical protein 774710 sufD 4441634 sufD Streptococcus pneumoniae D39 hypothetical protein YP_816250.1 773448 D 373153 CDS YP_816251.1 116516952 4442030 774721..775947 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0869; equivalent gene in S.pneumoniae R6 = spr0773; identified by match to protein family HMM PF00266; match to protein family HMM PF01212; match to protein family HMM TIGR01979; cysteine desulfurase SufS subfamily protein 775947 sufS 4442030 sufS Streptococcus pneumoniae D39 cysteine desulfurase SufS subfamily protein YP_816251.1 774721 D 373153 CDS YP_816252.1 116516679 4441353 775934..776374 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0870; equivalent gene in S.pneumoniae R6 = spr0774; identified by match to protein family HMM PF01592; match to protein family HMM TIGR01994; SUF system FeS assembly protein, NifU family protein 776374 4441353 SPD_0765 Streptococcus pneumoniae D39 SUF system FeS assembly protein, NifU family protein YP_816252.1 775934 D 373153 CDS YP_816253.1 116515674 4442540 776428..777840 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0871; equivalent gene in S.pneumoniae R6 = spr0775; identified by match to protein family HMM PF01458; match to protein family HMM TIGR01980; FeS assembly protein SufB 777840 sufB 4442540 sufB Streptococcus pneumoniae D39 FeS assembly protein SufB YP_816253.1 776428 D 373153 CDS YP_816254.1 116516506 4442627 complement(778039..779280) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0872; equivalent gene in S.pneumoniae R6 = spr0776; identified by match to protein family HMM PF00768; match to protein family HMM PF07943; D-alanyl-D-alanine carboxypeptidase 779280 dacC 4442627 dacC Streptococcus pneumoniae D39 D-alanyl-D-alanine carboxypeptidase YP_816254.1 778039 R 373153 CDS YP_816255.1 116516125 4442213 779383..780492 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0873; equivalent gene in S.pneumoniae R6 = spr0777; identified by match to protein family HMM PF01594; hypothetical protein 780492 4442213 SPD_0768 Streptococcus pneumoniae D39 hypothetical protein YP_816255.1 779383 D 373153 CDS YP_816256.1 116515565 4442875 781917..782657 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0875; equivalent gene in S.pneumoniae R6 = spr0778; identified by match to protein family HMM PF00455; match to protein family HMM PF08220; lactose phosphotransferase system repressor 782657 lacR1 4442875 lacR1 Streptococcus pneumoniae D39 lactose phosphotransferase system repressor YP_816256.1 781917 D 373153 CDS YP_816257.1 116516872 4442115 782654..783565 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0876; equivalent gene in S.pneumoniae R6 = spr0779; identified by match to protein family HMM PF00294; 1-phosphofructokinase 783565 4442115 SPD_0772 Streptococcus pneumoniae D39 1-phosphofructokinase YP_816257.1 782654 D 373153 CDS YP_816258.1 116516221 4441481 783562..785514 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0877; equivalent gene in S.pneumoniae R6 = spr0780; identified by match to protein family HMM PF00359; match to protein family HMM PF02378; match to protein family HMM PF02379; match to protein family HMM TIGR00829; match to protein family HMM TIGR00848; match to protein family HMM TIGR01427; PTS system fructose specific transporter subunit IIABC 785514 4441481 SPD_0773 Streptococcus pneumoniae D39 PTS system fructose specific transporter subunit IIABC YP_816258.1 783562 D 373153 CDS YP_816259.1 116517016 4441961 785600..787903 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0878; equivalent gene in S.pneumoniae R6 = spr0781; identified by match to protein family HMM PF01580; SpoE family protein 787903 4441961 SPD_0774 Streptococcus pneumoniae D39 SpoE family protein YP_816259.1 785600 D 373153 CDS YP_816260.1 116516509 4442630 complement(787948..788481) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0879; equivalent gene in S.pneumoniae R6 = spr0782; hypothetical protein 788481 4442630 SPD_0775 Streptococcus pneumoniae D39 hypothetical protein YP_816260.1 787948 R 373153 CDS YP_816261.1 116515406 4442476 788514..789656 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0880; equivalent gene in S.pneumoniae R6 = spr0783; identified by match to protein family HMM PF00266; class V aminotransferase 789656 4442476 SPD_0776 Streptococcus pneumoniae D39 class V aminotransferase YP_816261.1 788514 D 373153 CDS YP_816262.1 116516659 4443063 789665..790879 1 NC_008533.1 Required for the synthesis of the thiazole moiety; thiamine biosynthesis protein ThiI 790879 thiI 4443063 thiI Streptococcus pneumoniae D39 thiamine biosynthesis protein ThiI YP_816262.1 789665 D 373153 CDS YP_816263.1 116515554 4442728 791014..791838 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0882; equivalent gene in S.pneumoniae R6 = spr0785; identified by match to protein family HMM PF00756; hypothetical protein 791838 4442728 SPD_0778 Streptococcus pneumoniae D39 hypothetical protein YP_816263.1 791014 D 373153 CDS YP_816264.1 116517027 4441972 791860..792195 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0883; equivalent gene in S.pneumoniae R6 = spr0786; hypothetical protein 792195 4441972 SPD_0779 Streptococcus pneumoniae D39 hypothetical protein YP_816264.1 791860 D 373153 CDS YP_816265.1 116516246 4441526 792195..792599 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0884; equivalent gene in S.pneumoniae R6 = spr0788; hypothetical protein 792599 4441526 SPD_0780 Streptococcus pneumoniae D39 hypothetical protein YP_816265.1 792195 D 373153 CDS YP_816266.1 116517060 4441948 792612..793778 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0885; equivalent gene in S.pneumoniae R6 = spr0789; hypothetical protein 793778 4441948 SPD_0781 Streptococcus pneumoniae D39 hypothetical protein YP_816266.1 792612 D 373153 CDS YP_816267.1 116515872 4441110 794286..795779 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0886; equivalent gene in S.pneumoniae R6 = spr0790; identified by match to protein family HMM PF02384; type I restriction-modification system, M subunit 795779 4441110 SPD_0782 Streptococcus pneumoniae D39 type I restriction-modification system, M subunit YP_816267.1 794286 D 373153 CDS YP_816268.1 116515342 4441084 795792..796403 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0887; equivalent gene in S.pneumoniae R6 = spr0791; identified by match to protein family HMM PF01420; type I restriction-modification system subunit S 796403 4441084 SPD_0783 Streptococcus pneumoniae D39 type I restriction-modification system subunit S YP_816268.1 795792 D 373153 CDS YP_816269.1 116516102 4441627 796482..799832 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0892; equivalent gene in S.pneumoniae R6 = spr0792; identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM PF04313; match to protein family HMM PF04851; type I restriction-modification system, R subunit 799832 4441627 SPD_0784 Streptococcus pneumoniae D39 type I restriction-modification system, R subunit YP_816269.1 796482 D 373153 CDS YP_816270.1 116515667 4441250 800103..800303 1 NC_008533.1 hypothetical protein 800303 4441250 SPD_0785 Streptococcus pneumoniae D39 hypothetical protein YP_816270.1 800103 D 373153 CDS YP_816271.1 116516573 4442094 complement(800418..800888) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0893; equivalent gene in S.pneumoniae R6 = spr0793; identified by match to protein family HMM PF01316; match to protein family HMM PF02863; transcriptional regulator of arginine metabolism expression 800888 4442094 SPD_0786 Streptococcus pneumoniae D39 transcriptional regulator of arginine metabolism expression YP_816271.1 800418 R 373153 CDS YP_816272.1 116516024 4441586 complement(800905..803178) 1 NC_008533.1 catalyzes the removal of N-terminal dipeptides when proline is the penultimate residue; x-prolyl-dipeptidyl aminopeptidase 803178 pepX 4441586 pepX Streptococcus pneumoniae D39 x-prolyl-dipeptidyl aminopeptidase YP_816272.1 800905 R 373153 CDS YP_816273.1 116516844 4442164 803524..806625 1 NC_008533.1 Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. Proposed to be responsible for the synthesis of the lagging strand. In the low GC gram positive bacteria this enzyme is less processive and more error prone than its counterpart in other bacteria.; DNA polymerase III DnaE 806625 dnaE 4442164 dnaE Streptococcus pneumoniae D39 DNA polymerase III DnaE YP_816273.1 803524 D 373153 CDS YP_816274.1 116515997 4441501 806708..807715 1 NC_008533.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 807715 pfkA 4441501 pfkA Streptococcus pneumoniae D39 6-phosphofructokinase YP_816274.1 806708 D 373153 CDS YP_816275.1 116516870 4442113 807774..809279 1 NC_008533.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 809279 pyk 4442113 pyk Streptococcus pneumoniae D39 pyruvate kinase YP_816275.1 807774 D 373153 CDS YP_816276.1 116515522 4443003 complement(810396..810650) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0798; hypothetical protein 810650 4443003 SPD_0791 Streptococcus pneumoniae D39 hypothetical protein YP_816276.1 810396 R 373153 CDS YP_816277.1 116516105 4441630 811086..811958 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0899; equivalent gene in S.pneumoniae R6 = spr0799; hypothetical protein 811958 4441630 SPD_0792 Streptococcus pneumoniae D39 hypothetical protein YP_816277.1 811086 D 373153 CDS YP_816278.1 116515678 4442544 811971..812135 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0800; hypothetical protein 812135 4442544 SPD_0793 Streptococcus pneumoniae D39 hypothetical protein YP_816278.1 811971 D 373153 CDS YP_816279.1 116516083 4442677 812591..812902 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0901; equivalent gene in S.pneumoniae R6 = spr0802; hypothetical protein 812902 4442677 SPD_0795 Streptococcus pneumoniae D39 hypothetical protein YP_816279.1 812591 D 373153 CDS YP_816280.1 116517170 4441845 812906..813622 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0803; hypothetical protein 813622 4441845 SPD_0796 Streptococcus pneumoniae D39 hypothetical protein YP_816280.1 812906 D 373153 CDS YP_816281.1 116516749 4442299 complement(813752..814567) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0904; equivalent gene in S.pneumoniae R6 = spr0804; hypothetical protein 814567 4442299 SPD_0797 Streptococcus pneumoniae D39 hypothetical protein YP_816281.1 813752 R 373153 CDS YP_816282.1 116516828 4442185 complement(814564..815469) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0905; equivalent gene in S.pneumoniae R6 = spr0805; identified by match to protein family HMM PF03773; hypothetical protein 815469 4442185 SPD_0798 Streptococcus pneumoniae D39 hypothetical protein YP_816282.1 814564 R 373153 CDS YP_816283.1 116515502 4441312 complement(815470..815601) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0906; hypothetical protein 815601 4441312 SPD_0799 Streptococcus pneumoniae D39 hypothetical protein YP_816283.1 815470 R 373153 CDS YP_816284.1 116516341 4442826 815811..816170 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0907; equivalent gene in S.pneumoniae R6 = spr0806 The TIGR4 equivalent gene has 130 more amino acids than the D39 or R6 genes.; capsular polysaccharide biosynthesis protein 816170 4442826 SPD_0800 Streptococcus pneumoniae D39 capsular polysaccharide biosynthesis protein YP_816284.1 815811 D 373153 CDS YP_816285.1 116517174 4441850 816133..817179 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0907; equivalent gene in S.pneumoniae R6 = spr0807; hypothetical protein 817179 4441850 SPD_0801 Streptococcus pneumoniae D39 hypothetical protein YP_816285.1 816133 D 373153 CDS YP_816286.1 116516081 4442538 817281..819410 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0908; equivalent gene in S.pneumoniae R6 = spr0808; identified by match to protein family HMM PF00575; S1 RNA-binding domain-containing protein 819410 4442538 SPD_0802 Streptococcus pneumoniae D39 S1 RNA-binding domain-containing protein YP_816286.1 817281 D 373153 CDS YP_816287.1 116516907 4442054 819905..820177 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0910; equivalent gene in S.pneumoniae R6 = spr0810; identified by match to protein family HMM PF04024; hypothetical protein 820177 4442054 SPD_0803 Streptococcus pneumoniae D39 hypothetical protein YP_816287.1 819905 D 373153 CDS YP_816288.1 116515744 4441033 821150..821908 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0912; equivalent gene in S.pneumoniae R6 = spr0812; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 821908 4441033 SPD_0804 Streptococcus pneumoniae D39 ABC transporter ATP-binding protein YP_816288.1 821150 D 373153 CDS YP_816289.1 116516245 4441525 821910..823898 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0913; equivalent gene in S.pneumoniae R6 = spr0813; identified by match to protein family HMM PF02687; transporter permease 823898 4441525 SPD_0805 Streptococcus pneumoniae D39 transporter permease YP_816289.1 821910 D 373153 CDS YP_816290.1 116515380 4441616 complement(823941..824531) 1 NC_008533.1 Gene encodes 3 transmembrane regions. equivalent gene in S.pneumoniae TIGR4 = SP0914; equivalent gene in S.pneumoniae R6 spr0814; identified by match to protein family HMM PF01988; hypothetical protein 824531 4441616 SPD_0806 Streptococcus pneumoniae D39 hypothetical protein YP_816290.1 823941 R 373153 CDS YP_816291.1 116516434 4441660 complement(824611..825486) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0915; equivalent gene in S.pneumoniae R6 = spr0815; identified by match to protein family HMM PF00665; IS1239, transposase 825486 4441660 SPD_0807 Streptococcus pneumoniae D39 IS1239, transposase YP_816291.1 824611 R 373153 CDS YP_816292.1 116515443 4441290 complement(825719..825832) 1 NC_008533.1 hypothetical protein 825832 4441290 SPD_0808 Streptococcus pneumoniae D39 hypothetical protein YP_816292.1 825719 R 373153 CDS YP_816293.1 116516967 4442920 826193..827668 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0916; equivalent gene in S.pneumoniae R6 = spr0816; identified by match to protein family HMM PF00266; match to protein family HMM PF01212; match to protein family HMM PF01276; match to protein family HMM PF03711; lysine decarboxylase 827668 cad 4442920 cad Streptococcus pneumoniae D39 lysine decarboxylase YP_816293.1 826193 D 373153 CDS YP_816294.1 116515725 4442263 828605..829465 1 NC_008533.1 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase 829465 speE 4442263 speE Streptococcus pneumoniae D39 spermidine synthase YP_816294.1 828605 D 373153 CDS YP_816295.1 116516766 4442277 829462..830721 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0919; equivalent gene in S.pneumoniae R6 = spr0820; identified by match to protein family HMM PF03435; hypothetical protein 830721 lys1 4442277 lys1 Streptococcus pneumoniae D39 hypothetical protein YP_816295.1 829462 D 373153 CDS YP_816296.1 116515395 4442465 830721..831848 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0920; equivalent gene in S.pneumoniae R6 = spr0821; identified by match to protein family HMM PF00278; match to protein family HMM TIGR01047; carboxynorspermidine decarboxylase 831848 nspC 4442465 nspC Streptococcus pneumoniae D39 carboxynorspermidine decarboxylase YP_816296.1 830721 D 373153 CDS YP_816297.1 116516045 4442754 831845..832930 1 NC_008533.1 agmatine iminohydrolase; catalyzes the formation of carbamoylputrescine from agmatine in the arginine decarboxylase pathway of putrescine biosynthesis; agmatine deiminase 832930 4442754 SPD_0814 Streptococcus pneumoniae D39 agmatine deiminase YP_816297.1 831845 D 373153 CDS YP_816298.1 116516894 4442079 832940..833815 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0922; equivalent gene in S.pneumoniae R6 = spr0823; identified by match to protein family HMM PF00795; carbon-nitrogen hydrolase 833815 4442079 SPD_0815 Streptococcus pneumoniae D39 carbon-nitrogen hydrolase YP_816298.1 832940 D 373153 CDS YP_816299.1 116516008 4441570 complement(833996..834805) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0923; equivalent gene in S.pneumoniae R6 = spr0824; identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; Cof family protein 834805 4441570 SPD_0816 Streptococcus pneumoniae D39 Cof family protein YP_816299.1 833996 R 373153 CDS YP_816300.1 116516715 4442341 835352..836023 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0925; equivalent gene in S.pneumoniae R6 = spr0826; identified by match to protein family HMM PF02517; hypothetical protein 836023 4442341 SPD_0817 Streptococcus pneumoniae D39 hypothetical protein YP_816300.1 835352 D 373153 CDS YP_816301.1 116515669 4441252 836265..837173 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0927; equivalent gene in S.pneumoniae R6 = spr0828; identified by match to protein family HMM PF00126; match to protein family HMM PF03466; transcriptional regulator, LysR family protein 837173 4441252 SPD_0818 Streptococcus pneumoniae D39 transcriptional regulator, LysR family protein YP_816301.1 836265 D 373153 CDS YP_816302.1 116516537 4441040 837170..837631 1 NC_008533.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 837631 lspA 4441040 lspA Streptococcus pneumoniae D39 lipoprotein signal peptidase YP_816302.1 837170 D 373153 CDS YP_816303.1 116515398 4442468 837621..838508 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0929; equivalent gene in S.pneumoniae R6 = spr0830; identified by match to protein family HMM PF00849; match to protein family HMM PF01479; match to protein family HMM TIGR00005; ribosomal large subunit pseudouridine synthase D 838508 rluD 4442468 rluD Streptococcus pneumoniae D39 ribosomal large subunit pseudouridine synthase D YP_816303.1 837621 D 373153 CDS YP_816304.1 116516225 4441485 838511..840394 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0930; equivalent gene in S.pneumoniae R6 = spr0831; identified by match to protein family HMM PF00753; match to protein family HMM PF01473; choline binding protein E 840394 cbpE 4441485 cbpE Streptococcus pneumoniae D39 choline binding protein E YP_816304.1 838511 D 373153 CDS YP_816305.1 116516764 4442275 840495..841604 1 NC_008533.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 841604 proB 4442275 proB Streptococcus pneumoniae D39 gamma-glutamyl kinase YP_816305.1 840495 D 373153 CDS YP_816306.1 116516154 4442516 841614..842876 1 NC_008533.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 842876 proA 4442516 proA Streptococcus pneumoniae D39 gamma-glutamyl phosphate reductase YP_816306.1 841614 D 373153 CDS YP_816307.1 116516457 4442577 842880..843677 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0933; equivalent gene in S.pneumoniae R6 = spr0834; identified by match to protein family HMM PF01210; match to protein family HMM PF03446; match to protein family HMM PF03807; match to protein family HMM TIGR00112; pyrroline-5-carboxylate reductase 843677 proC 4442577 proC Streptococcus pneumoniae D39 pyrroline-5-carboxylate reductase YP_816307.1 842880 D 373153 CDS YP_816308.1 116516561 4441266 843793..844431 1 NC_008533.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 844431 tmk 4441266 tmk Streptococcus pneumoniae D39 thymidylate kinase YP_816308.1 843793 D 373153 CDS YP_816309.1 116515715 4442252 844428..845318 1 NC_008533.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA.; DNA polymerase III subunit delta' 845318 holB 4442252 holB Streptococcus pneumoniae D39 DNA polymerase III subunit delta' YP_816309.1 844428 D 373153 CDS YP_816310.1 116516332 4442815 845358..845675 1 NC_008533.1 in Bacillus subtilis this protein is involved in the negative regulation of DNA replication initiation; interacts with DnaN and DnaA; DNA replication intiation control protein YabA 845675 4442815 SPD_0827 Streptococcus pneumoniae D39 DNA replication intiation control protein YabA YP_816310.1 845358 D 373153 CDS YP_816311.1 116515519 4443000 845678..846547 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0938; equivalent gene in S.pneumoniae R6 = spr0838; identified by match to protein family HMM PF00590; match to protein family HMM TIGR00096; hypothetical protein 846547 4443000 SPD_0828 Streptococcus pneumoniae D39 hypothetical protein YP_816311.1 845678 D 373153 CDS YP_816312.1 116517217 4441815 846774..847292 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0939; equivalent gene in S.pneumoniae R6 = spr0839; identified by match to protein family HMM PF08020; hypothetical protein 847292 4441815 SPD_0829 Streptococcus pneumoniae D39 hypothetical protein YP_816312.1 846774 D 373153 CDS YP_816313.1 116516415 4442981 847401..848048 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0840; identified by match to protein family HMM PF06970; hypothetical protein 848048 4442981 SPD_0831 Streptococcus pneumoniae D39 hypothetical protein YP_816313.1 847401 D 373153 CDS YP_816314.1 116516019 4441581 complement(848037..848426) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0538; equivalent gene in S.pneumoniae R6 = spr0841; identified by match to protein family HMM PF01609; IS1381, transposase OrfB 848426 4441581 SPD_0830 Streptococcus pneumoniae D39 IS1381, transposase OrfB YP_816314.1 848037 R 373153 CDS YP_816315.1 116516286 4442614 complement(848452..848841) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0942; equivalent gene in S.pneumoniae R6 = spr0842; IS1381, transposase OrfA 848841 4442614 SPD_0832 Streptococcus pneumoniae D39 IS1381, transposase OrfA YP_816315.1 848452 R 373153 CDS YP_816316.1 116516642 4441431 849335..850669 1 NC_008533.1 TrmFO; Gid; glucose-inhibited division protein; similar to GidA; the gene from Bacillus subtilis encodes a tRNA-methyltransferase that utilizes folate as the carbon donor and bound flavin as reductant; modifies tRNA at position 54 (uridine) of the T-psi loop to form a C5-methyluridine; tRNA (uracil-5-)-methyltransferase Gid 850669 gid 4441431 gid Streptococcus pneumoniae D39 tRNA (uracil-5-)-methyltransferase Gid YP_816316.1 849335 D 373153 CDS YP_816317.1 116515310 4441192 850753..851490 1 NC_008533.1 Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 851490 pyrH 4441192 pyrH Streptococcus pneumoniae D39 uridylate kinase YP_816317.1 850753 D 373153 CDS YP_816318.1 116516857 4442138 851499..852056 1 NC_008533.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 852056 frr 4442138 frr Streptococcus pneumoniae D39 ribosome recycling factor YP_816318.1 851499 D 373153 CDS YP_816319.1 116515585 4441205 852077..852970 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0946; equivalent gene in S.pneumoniae R6 = spr0847; hypothetical protein 852970 4441205 SPD_0836 Streptococcus pneumoniae D39 hypothetical protein YP_816319.1 852077 D 373153 CDS YP_816320.1 116517068 4441917 852979..853194 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0947; equivalent gene in S.pneumoniae R6 = spr0848; identified by match to protein family HMM PF06855; hypothetical protein 853194 4441917 SPD_0837 Streptococcus pneumoniae D39 hypothetical protein YP_816320.1 852979 D 373153 CDS YP_816321.1 116516028 4441688 853280..854248 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0948; equivalent gene in S.pneumoniae R6 = spr0849; identified by match to protein family HMM PF02562; PhoH family protein 854248 4441688 SPD_0838 Streptococcus pneumoniae D39 PhoH family protein YP_816321.1 853280 D 373153 CDS YP_816322.1 116516254 4441764 854441..854941 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0950; equivalent gene in S.pneumoniae R6 = spr0850; identified by match to protein family HMM PF00583; GNAT family acetyltransferase 854941 4441764 SPD_0839 Streptococcus pneumoniae D39 GNAT family acetyltransferase YP_816322.1 854441 D 373153 CDS YP_816323.1 116517123 4441895 854944..855171 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0951; equivalent gene in S.pneumoniae R6 = spr0851; hypothetical protein 855171 4441895 SPD_0840 Streptococcus pneumoniae D39 hypothetical protein YP_816323.1 854944 D 373153 CDS YP_816324.1 116515995 4441498 856859..857428 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0953; equivalent gene in S.pneumoniae R6 = spr0855; identified by match to protein family HMM PF00583; GNAT family acetyltransferase 857428 4441498 SPD_0842 Streptococcus pneumoniae D39 GNAT family acetyltransferase YP_816324.1 856859 D 373153 CDS YP_816325.1 116516340 4442825 857496..858146 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0954; equivalent gene in S.pneumoniae R6 = spr0856; identified by match to protein family HMM PF00633; match to protein family HMM TIGR00426; match to protein family HMM TIGR01259; competence protein CelA 858146 celA 4442825 celA Streptococcus pneumoniae D39 competence protein CelA YP_816325.1 857496 D 373153 CDS YP_816326.1 116515500 4441310 858130..860370 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0955; equivalent gene in S.pneumoniae R6 = spr0857; identified by match to protein family HMM PF03772; match to protein family HMM TIGR00360; match to protein family HMM TIGR00361; competence protein CelB 860370 celB 4441310 celB Streptococcus pneumoniae D39 competence protein CelB YP_816326.1 858130 D 373153 CDS YP_816327.1 116516074 4442531 860769..861245 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0957; equivalent gene in S.pneumoniae R6 = spr0859; ABC transporter ATP-binding protein 861245 4442531 SPD_0845 Streptococcus pneumoniae D39 ABC transporter ATP-binding protein YP_816327.1 860769 D 373153 CDS YP_816328.1 116517169 4441844 861360..862541 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0958; equivalent gene in S.pneumoniae R6 = spr0860; hypothetical protein 862541 4441844 SPD_0846 Streptococcus pneumoniae D39 hypothetical protein YP_816328.1 861360 D 373153 CDS YP_816329.1 116515644 4441324 862821..863378 1 NC_008533.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits; translation initiation factor IF-3 863378 infC 4441324 infC Streptococcus pneumoniae D39 translation initiation factor IF-3 YP_816329.1 862821 D 373153 CDS YP_816330.1 116516458 4442928 863411..863611 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0960; equivalent gene in S.pneumoniae R6 = spr0862; identified by match to protein family HMM PF01632; match to protein family HMM TIGR00001; 50S ribosomal protein L35 863611 rpmI 4442928 rpmI Streptococcus pneumoniae D39 50S ribosomal protein L35 YP_816330.1 863411 D 373153 CDS YP_816331.1 116516545 4441049 863663..864022 1 NC_008533.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 864022 rplT 4441049 rplT Streptococcus pneumoniae D39 50S ribosomal protein L20 YP_816331.1 863663 D 373153 CDS YP_816332.1 116515712 4442249 864080..864460 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0962; equivalent gene in S.pneumoniae R6 = spr0864; identified by match to protein family HMM PF00903; lactoylglutathione lyase 864460 gloA 4442249 gloA Streptococcus pneumoniae D39 lactoylglutathione lyase YP_816332.1 864080 D 373153 CDS YP_816333.1 116515976 4442427 864710..865510 1 NC_008533.1 responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the pyrD subunit to the ultimate electron acceptor NAD(+); dihydroorotate dehydrogenase electron transfer subunit 865510 pyrK 4442427 pyrK Streptococcus pneumoniae D39 dihydroorotate dehydrogenase electron transfer subunit YP_816333.1 864710 D 373153 CDS YP_816334.1 116517057 4441945 865521..866459 1 NC_008533.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway, using a flavin nucleotide as an essential cofactor; subclass 1B is a heterotetramer consisting of two PyrDB subunits, similar to the PyrDA subunits and two PyrK subunits; dihydroorotate dehydrogenase 1B 866459 pyrDb 4441945 pyrDb Streptococcus pneumoniae D39 dihydroorotate dehydrogenase 1B YP_816334.1 865521 D 373153 CDS YP_816335.1 116517112 4441884 866558..868666 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0867; identified by match to protein family HMM PF01473; match to protein family HMM PF01832; endo-beta-N-acetylglucosaminidase 868666 lytB 4441884 lytB Streptococcus pneumoniae D39 endo-beta-N-acetylglucosaminidase YP_816335.1 866558 D 373153 CDS YP_816336.1 116516285 4442613 complement(868727..870382) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0966; equivalent gene in S.pneumoniae R6 = spr0868; identified by match to protein family HMM PF05670; match to protein family HMM PF05833; adherence and virulence protein A 870382 pavA 4442613 pavA Streptococcus pneumoniae D39 adherence and virulence protein A YP_816336.1 868727 R 373153 CDS YP_816337.1 116516344 4442829 870487..870984 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0967; equivalent gene in S.pneumoniae R6 = spr0869; identified by match to protein family HMM PF02130; match to protein family HMM TIGR00043; metalloprotease 870984 4442829 SPD_0855 Streptococcus pneumoniae D39 metalloprotease YP_816337.1 870487 D 373153 CDS YP_816338.1 116515614 4442753 870965..871360 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0968; equivalent gene in S.pneumoniae R6 = spr0870; identified by match to protein family HMM PF01219; diacylglycerol kinase 871360 dgkA 4442753 dgkA Streptococcus pneumoniae D39 diacylglycerol kinase YP_816338.1 870965 D 373153 CDS YP_816339.1 116516762 4442273 871377..872276 1 NC_008533.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 872276 era 4442273 era Streptococcus pneumoniae D39 GTP-binding protein Era YP_816339.1 871377 D 373153 CDS YP_816340.1 116515925 4441068 872325..873149 1 NC_008533.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 873149 mutM 4441068 mutM Streptococcus pneumoniae D39 formamidopyrimidine-DNA glycosylase YP_816340.1 872325 D 373153 CDS YP_816341.1 116516997 4441980 873149..873754 1 NC_008533.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase 873754 coaE 4441980 coaE Streptococcus pneumoniae D39 dephospho-CoA kinase YP_816341.1 873149 D 373153 CDS YP_816342.1 116516183 4441140 873741..874940 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0972; equivalent gene in S.pneumoniae R6 = spr0875; identified by match to protein family HMM PF07690; multi-drug resistance efflux pump 874940 pmrA 4441140 pmrA Streptococcus pneumoniae D39 multi-drug resistance efflux pump YP_816342.1 873741 D 373153 CDS YP_816343.1 116516845 4442165 875129..875362 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0974; equivalent gene in S.pneumoniae R6 = spr0877; identified by match to protein family HMM PF03840; match to protein family HMM TIGR00810; preprotein translocase subunit SecG 875362 secG 4442165 secG Streptococcus pneumoniae D39 preprotein translocase subunit SecG YP_816343.1 875129 D 373153 CDS YP_816344.1 116515936 4441338 875464..877818 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0975; equivalent gene in S.pneumoniae R6 = spr0878; identified by match to protein family HMM PF00575; match to protein family HMM PF00773; match to protein family HMM PF08206; match to protein family HMM TIGR00358; match to protein family HMM TIGR02063; ribonuclease R 877818 rnr 4441338 rnr Streptococcus pneumoniae D39 ribonuclease R YP_816344.1 875464 D 373153 CDS YP_816345.1 116516450 4442569 877781..878248 1 NC_008533.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 878248 smpB 4442569 smpB Streptococcus pneumoniae D39 SsrA-binding protein YP_816345.1 877781 D 373153 CDS YP_816346.1 116515607 4442746 878264..879124 1 NC_008533.1 with TehA confers resistance to tellurite; tellurite resistance protein TehB 879124 tehB 4442746 tehB Streptococcus pneumoniae D39 tellurite resistance protein TehB YP_816346.1 878264 D 373153 CDS YP_816347.1 116516258 4441768 879197..880150 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0978; equivalent gene in S.pneumoniae R6 = spr0881; identified by match to protein family HMM PF06054; competence protein CoiA 880150 coiA 4441768 coiA Streptococcus pneumoniae D39 competence protein CoiA YP_816347.1 879197 D 373153 CDS YP_816348.1 116515412 4442482 880169..881971 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0979; equivalent gene in S.pneumoniae R6 = spr0882; identified by match to protein family HMM PF01432; match to protein family HMM TIGR00181; oligoendopeptidase F 881971 pepF 4442482 pepF Streptococcus pneumoniae D39 oligoendopeptidase F YP_816348.1 880169 D 373153 CDS YP_816349.1 116516018 4441580 881973..882686 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0980; equivalent gene in S.pneumoniae R6 = spr0883; identified by match to protein family HMM PF01596; O-methyltransferase 882686 4441580 SPD_0867 Streptococcus pneumoniae D39 O-methyltransferase YP_816349.1 881973 D 373153 CDS YP_816350.1 116517083 4441933 882753..883694 1 NC_008533.1 cis/trans isomerase of peptidylprolyl; PPIase; membrane-bound lipoprotein; foldase protein PrsA 883694 prsA 4441933 prsA Streptococcus pneumoniae D39 foldase protein PrsA YP_816350.1 882753 D 373153 CDS YP_816351.1 116515927 4441070 complement(883912..884154) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1485; equivalent gene in S.pneumoniae R6 = spr0885; hypothetical protein 884154 4441070 SPD_0869 Streptococcus pneumoniae D39 hypothetical protein YP_816351.1 883912 R 373153 CDS YP_816352.1 116516753 4442303 complement(884914..885534) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0984; equivalent gene in S.pneumoniae R6 = spr0887; identified by match to protein family HMM PF00300; phosphoglycerate mutase family protein 885534 4442303 SPD_0870 Streptococcus pneumoniae D39 phosphoglycerate mutase family protein YP_816352.1 884914 R 373153 CDS YP_816353.1 116516113 4441638 complement(885534..886016) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0985; equivalent gene in S.pneumoniae R6 = spr0888; identified by match to protein family HMM PF04073; regulatory protein 886016 4441638 SPD_0871 Streptococcus pneumoniae D39 regulatory protein YP_816353.1 885534 R 373153 CDS YP_816354.1 116516986 4442007 complement(886016..886858) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0986; equivalent gene in S.pneumoniae R6 = spr0889; identified by match to protein family HMM PF04018; hypothetical protein 886858 4442007 SPD_0872 Streptococcus pneumoniae D39 hypothetical protein YP_816354.1 886016 R 373153 CDS YP_816355.1 116517017 4441962 complement(886953..887753) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0987; equivalent gene in S.pneumoniae R6 = spr0890; identified by match to protein family HMM PF01183; hypothetical protein 887753 4441962 SPD_0873 Streptococcus pneumoniae D39 hypothetical protein YP_816355.1 886953 R 373153 CDS YP_816356.1 116516172 4442846 887897..889276 1 NC_008533.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 889276 glmU 4442846 glmU Streptococcus pneumoniae D39 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase YP_816356.1 887897 D 373153 CDS YP_816357.1 116515368 4441168 889286..889831 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0989; equivalent gene in S.pneumoniae R6 = spr0892; identified by match to protein family HMM PF00293; NUDIX family hydrolase 889831 4441168 SPD_0875 Streptococcus pneumoniae D39 NUDIX family hydrolase YP_816357.1 889286 D 373153 CDS YP_816358.1 116516438 4441664 889843..890157 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0990; equivalent gene in S.pneumoniae R6 = spr0893; hypothetical protein 890157 4441664 SPD_0876 Streptococcus pneumoniae D39 hypothetical protein YP_816358.1 889843 D 373153 CDS YP_816359.1 116516739 4442289 890174..890866 1 NC_008533.1 enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 890866 mtnN 4442289 mtnN Streptococcus pneumoniae D39 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase YP_816359.1 890174 D 373153 CDS YP_816360.1 116515331 4442674 890943..891434 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0992; equivalent gene in S.pneumoniae R6 = spr0895; identified by match to protein family HMM PF04394; hypothetical protein 891434 4442674 SPD_0878 Streptococcus pneumoniae D39 hypothetical protein YP_816360.1 890943 D 373153 CDS YP_816361.1 116515938 4441340 891532..892122 1 NC_008533.1 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 892122 4441340 SPD_0879 Streptococcus pneumoniae D39 DNA polymerase III subunit epsilon YP_816361.1 891532 D 373153 CDS YP_816362.1 116516500 4442621 892131..893894 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0994; equivalent gene in S.pneumoniae R6 = spr0897; identified by match to protein family HMM PF03009; hypothetical protein 893894 4442621 SPD_0880 Streptococcus pneumoniae D39 hypothetical protein YP_816362.1 892131 D 373153 CDS YP_816363.1 116515422 4442492 894614..894754 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0899; IS630-Spn1, transposase Orf2, truncation 894754 4442492 SPD_0882 Streptococcus pneumoniae D39 IS630-Spn1, transposase Orf2, truncation YP_816363.1 894614 D 373153 CDS YP_816364.1 116516489 4443019 894915..895115 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0997; equivalent gene in S.pneumoniae R6 = spr0900; hypothetical protein 895115 4443019 SPD_0883 Streptococcus pneumoniae D39 hypothetical protein YP_816364.1 894915 D 373153 CDS YP_816365.1 116517020 4441965 895157..895561 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0998; equivalent gene in S.pneumoniae R6 = spr0902; hypothetical protein 895561 4441965 SPD_0884 Streptococcus pneumoniae D39 hypothetical protein YP_816365.1 895157 D 373153 CDS YP_816366.1 116516271 4442599 895792..896499 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0999; equivalent gene in S.pneumoniae R6 = spr0903; identified by match to protein family HMM PF02683; cytochrome c-type biogenesis protein CcdA 896499 ccdA-2 4442599 ccdA-2 Streptococcus pneumoniae D39 cytochrome c-type biogenesis protein CcdA YP_816366.1 895792 D 373153 CDS YP_816367.1 116517059 4441947 896510..897067 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1000; equivalent gene in S.pneumoniae R6 = spr0904; thioredoxin family protein 897067 4441947 SPD_0886 Streptococcus pneumoniae D39 thioredoxin family protein YP_816367.1 896510 D 373153 CDS YP_816368.1 116516274 4442602 897441..898832 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1001; equivalent gene in S.pneumoniae R6 = spr0905; identified by match to protein family HMM PF00324; amino acid permease family protein 898832 4442602 SPD_0887 Streptococcus pneumoniae D39 amino acid permease family protein YP_816368.1 897441 D 373153 CDS YP_816369.1 116515739 4441027 898975..899892 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1002; equivalent gene in S.pneumoniae R6 = spr0906; identified by match to protein family HMM PF01297; adhesion lipoprotein 899892 lmb 4441027 lmb Streptococcus pneumoniae D39 adhesion lipoprotein YP_816369.1 898975 D 373153 CDS YP_816370.1 116516147 4442509 899900..902461 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1003; equivalent gene in S.pneumoniae R6 = spr0907; identified by match to protein family HMM PF04270; match to protein family HMM TIGR01363; histidine triad protein D 902461 phtD 4442509 phtD Streptococcus pneumoniae D39 histidine triad protein D YP_816370.1 899900 D 373153 CDS YP_816371.1 116516522 4443073 902671..905790 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1004; equivalent gene in S.pneumoniae R6 = spr0908; identified by match to protein family HMM PF04270; match to protein family HMM TIGR01363; histidine triad protein E 905790 phtE 4443073 phtE Streptococcus pneumoniae D39 histidine triad protein E YP_816371.1 902671 D 373153 CDS YP_816372.1 116516916 4442065 907590..908219 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1007; equivalent gene in S.pneumoniae R6 = spr0912; hypothetical protein 908219 4442065 SPD_0893 Streptococcus pneumoniae D39 hypothetical protein YP_816372.1 907590 D 373153 CDS YP_816373.1 116515861 4441097 complement(908262..909482) 1 NC_008533.1 catalyzes the release of the N-terminal amino acid from a tripeptide; peptidase T 909482 pepT 4441097 pepT Streptococcus pneumoniae D39 peptidase T YP_816373.1 908262 R 373153 CDS YP_816374.1 116517033 4442347 909637..910731 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1009; equivalent gene in S.pneumoniae R6 = spr0914; identified by match to protein family HMM PF00762; match to protein family HMM TIGR00109; ferrochelatase 910731 hemH 4442347 hemH Streptococcus pneumoniae D39 ferrochelatase YP_816374.1 909637 D 373153 CDS YP_816375.1 116516166 4442840 complement(910773..911150) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1010; equivalent gene in S.pneumoniae R6 = spr0915 Protein encodes a channel which opens in response to a membrane stretch force. Probably serves as an osmotic gauge. Carboxy terminus tends to be more divergent across species with a high degree of sequence conservation found at the N-terminus; identified by match to protein family HMM PF01741; match to protein family HMM TIGR00220; large conductance mechanosensitive channel protein MscL 911150 mscL 4442840 mscL Streptococcus pneumoniae D39 large conductance mechanosensitive channel protein MscL YP_816375.1 910773 R 373153 CDS YP_816376.1 116517022 4441967 complement(911232..911663) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1011; equivalent gene in S.pneumoniae R6 = spr0916; identified by match to protein family HMM PF04138; GtrA family protein 911663 4441967 SPD_0897 Streptococcus pneumoniae D39 GtrA family protein YP_816376.1 911232 R 373153 CDS YP_816377.1 116515492 4441302 911786..912295 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1012; equivalent gene in S.pneumoniae R6 = spr0917; identified by match to protein family HMM PF06177; hypothetical protein 912295 4441302 SPD_0898 Streptococcus pneumoniae D39 hypothetical protein YP_816377.1 911786 D 373153 CDS YP_816378.1 116516437 4441663 912810..913886 1 NC_008533.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 913886 asd 4441663 asd Streptococcus pneumoniae D39 aspartate-semialdehyde dehydrogenase YP_816378.1 912810 D 373153 CDS YP_816379.1 116516238 4441518 913942..914877 1 NC_008533.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase 914877 dapA 4441518 dapA Streptococcus pneumoniae D39 dihydrodipicolinate synthase YP_816379.1 913942 D 373153 CDS YP_816380.1 116516848 4442168 complement(914924..916297) 1 NC_008533.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE 916297 trmE 4442168 trmE Streptococcus pneumoniae D39 tRNA modification GTPase TrmE YP_816380.1 914924 R 373153 CDS YP_816381.1 116515386 4441622 complement(916434..916616) 1 NC_008533.1 4-OT; member of subfamily 5; forms a dimer; the function in the Escherichia coli cell is unknown; 4-oxalocrotonate tautomerase 916616 xylH 4441622 xylH Streptococcus pneumoniae D39 4-oxalocrotonate tautomerase YP_816381.1 916434 R 373153 CDS YP_816382.1 116516420 4441646 916739..917338 1 NC_008533.1 catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 917338 tdk 4441646 tdk Streptococcus pneumoniae D39 thymidine kinase YP_816382.1 916739 D 373153 CDS YP_816383.1 116516070 4442526 917328..917807 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1019; equivalent gene in S.pneumoniae R6 = spr0923; identified by match to protein family HMM PF00583; GNAT family acetyltransferase 917807 4442526 SPD_0905 Streptococcus pneumoniae D39 GNAT family acetyltransferase YP_816383.1 917328 D 373153 CDS YP_816384.1 116517153 4441867 917817..918896 1 NC_008533.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 918896 prfA 4441867 prfA Streptococcus pneumoniae D39 peptide chain release factor 1 YP_816384.1 917817 D 373153 CDS YP_816385.1 116517180 4441856 918896..919735 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1021; equivalent gene in S.pneumoniae R6 = spr0925; identified by match to protein family HMM PF05175; match to protein family HMM TIGR00536; HemK protein 919735 hemK 4441856 hemK Streptococcus pneumoniae D39 HemK protein YP_816385.1 918896 D 373153 CDS YP_816386.1 116516461 4442931 919719..920321 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1022; equivalent gene in S.pneumoniae R6 = spr0926; identified by match to protein family HMM PF01300; match to protein family HMM TIGR00057; Sua5/YciO/YrdC/YwlC family protein 920321 4442931 SPD_0908 Streptococcus pneumoniae D39 Sua5/YciO/YrdC/YwlC family protein YP_816386.1 919719 D 373153 CDS YP_816387.1 116515388 4441624 920323..920754 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1023; equivalent gene in S.pneumoniae R6 = spr0927; identified by match to protein family HMM PF00583; GNAT family acetyltransferase 920754 4441624 SPD_0909 Streptococcus pneumoniae D39 GNAT family acetyltransferase YP_816387.1 920323 D 373153 CDS YP_816388.1 116517005 4441989 920816..922072 1 NC_008533.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 922072 glyA 4441989 glyA Streptococcus pneumoniae D39 serine hydroxymethyltransferase YP_816388.1 920816 D 373153 CDS YP_816389.1 116516178 4441135 922047..923054 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1025; equivalent gene in S.pneumoniae R6 = spr0929; hypothetical protein 923054 4441135 SPD_0911 Streptococcus pneumoniae D39 hypothetical protein YP_816389.1 922047 D 373153 CDS YP_816390.1 116516801 4442196 923054..923668 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1026; equivalent gene in S.pneumoniae R6 = spr0930; hypothetical protein 923668 pvaA 4442196 pvaA Streptococcus pneumoniae D39 hypothetical protein YP_816390.1 923054 D 373153 CDS YP_816391.1 116516896 4442081 923742..924716 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1027; equivalent gene in S.pneumoniae R6 = spr0931; identified by match to protein family HMM PF06207; hypothetical protein 924716 4442081 SPD_0913 Streptococcus pneumoniae D39 hypothetical protein YP_816391.1 923742 D 373153 CDS YP_816392.1 116515807 4442854 924790..926421 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1029; equivalent gene in S.pneumoniae R6 = spr0932; identified by match to protein family HMM PF01938; match to protein family HMM PF05958; match to protein family HMM TIGR00479; 23S rRNA (uracil-5-)-methyltransferase RumA 926421 rumA-1 4442854 rumA-1 Streptococcus pneumoniae D39 23S rRNA (uracil-5-)-methyltransferase RumA YP_816392.1 924790 D 373153 CDS YP_816393.1 116517168 4441843 927770..928795 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1032; equivalent gene in S.pneumoniae R6 = spr0934; identified by match to protein family HMM PF01497; iron-compound ABC transporter iron compound-binding protein 928795 4441843 SPD_0915 Streptococcus pneumoniae D39 iron-compound ABC transporter iron compound-binding protein YP_816393.1 927770 D 373153 CDS YP_816394.1 116516465 4442935 928785..929792 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1033; equivalent gene in S.pneumoniae R6 = spr0935; identified by match to protein family HMM PF01032; iron-compound ABC transporter permease 929792 4442935 SPD_0916 Streptococcus pneumoniae D39 iron-compound ABC transporter permease YP_816394.1 928785 D 373153 CDS YP_816395.1 116516717 4442343 929792..930799 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1034; equivalent gene in S.pneumoniae R6 = spr0936; identified by match to protein family HMM PF01032; iron-compound ABC transporter permease 930799 4442343 SPD_0917 Streptococcus pneumoniae D39 iron-compound ABC transporter permease YP_816395.1 929792 D 373153 CDS YP_816396.1 116515486 4441296 930799..931593 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1035; equivalent gene in S.pneumoniae R6 = spr0938; identified by match to protein family HMM PF00005; iron-compound ABC transporter ATP-binding protein 931593 4441296 SPD_0918 Streptococcus pneumoniae D39 iron-compound ABC transporter ATP-binding protein YP_816396.1 930799 D 373153 CDS YP_816397.1 116516970 4442923 932495..932650 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1038; equivalent gene in S.pneumoniae R6 = spr0940; hypothetical protein 932650 4442923 SPD_0919 Streptococcus pneumoniae D39 hypothetical protein YP_816397.1 932495 D 373153 CDS YP_816398.1 116515934 4441336 933334..933495 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1039; equivalent gene in S.pneumoniae R6 = spr0941; hypothetical protein 933495 4441336 SPD_0920 Streptococcus pneumoniae D39 hypothetical protein YP_816398.1 933334 D 373153 CDS YP_816399.1 116515333 4441075 933587..935266 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1040; equivalent gene in S.pneumoniae R6 = spr0942; identified by match to protein family HMM PF00239; match to protein family HMM PF07508; site-specific recombinase, resolvase family protein 935266 4441075 SPD_0921 Streptococcus pneumoniae D39 site-specific recombinase, resolvase family protein YP_816399.1 933587 D 373153 CDS YP_816400.1 116516667 4442447 935489..936100 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1041; equivalent gene in S.pneumoniae R6 = spr0943; hypothetical protein 936100 4442447 SPD_0922 Streptococcus pneumoniae D39 hypothetical protein YP_816400.1 935489 D 373153 CDS YP_816401.1 116515866 4441102 936413..936610 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1042; equivalent gene in S.pneumoniae R6 = spr0944; hypothetical protein 936610 4441102 SPD_0923 Streptococcus pneumoniae D39 hypothetical protein YP_816401.1 936413 D 373153 CDS YP_816402.1 116516982 4442002 936672..937487 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1043; equivalent gene in S.pneumoniae R6 = spr0945; hypothetical protein 937487 4442002 SPD_0924 Streptococcus pneumoniae D39 hypothetical protein YP_816402.1 936672 D 373153 CDS YP_816403.1 116516066 4442521 937487..938341 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1044; equivalent gene in S.pneumoniae R6 = spr0946; identified by match to protein family HMM PF03747; hydrolase 938341 4442521 SPD_0925 Streptococcus pneumoniae D39 hydrolase YP_816403.1 937487 D 373153 CDS YP_816404.1 116517124 4441896 938453..939337 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1045; equivalent gene in S.pneumoniae R6 = spr0947; identified by match to protein family HMM PF00781; match to protein family HMM TIGR00147; hypothetical protein 939337 4441896 SPD_0926 Streptococcus pneumoniae D39 hypothetical protein YP_816404.1 938453 D 373153 CDS YP_816405.1 116516706 4442332 939476..941239 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0948; identified by match to protein family HMM PF00128; match to protein family HMM PF02903; neopullulanase 941239 nplT 4442332 nplT Streptococcus pneumoniae D39 neopullulanase YP_816405.1 939476 D 373153 CDS YP_816406.1 116515723 4442261 941325..941642 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1047; equivalent gene in S.pneumoniae R6 = spr0949; hypothetical protein 941642 4442261 SPD_0928 Streptococcus pneumoniae D39 hypothetical protein YP_816406.1 941325 D 373153 CDS YP_816407.1 116515888 4441386 941688..941969 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1048; equivalent gene in S.pneumoniae R6 = spr0950; hypothetical protein 941969 4441386 SPD_0929 Streptococcus pneumoniae D39 hypothetical protein YP_816407.1 941688 D 373153 CDS YP_816408.1 116515960 4441401 942414..942890 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1050; equivalent gene in S.pneumoniae R6 = spr0951; identified by match to protein family HMM PF01381; transcriptional regulator 942890 4441401 SPD_0930 Streptococcus pneumoniae D39 transcriptional regulator YP_816408.1 942414 D 373153 CDS YP_816409.1 116515566 4442876 942890..943651 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1051; equivalent gene in S.pneumoniae R6 = spr0952; identified by match to protein family HMM PF06414; hypothetical protein 943651 4442876 SPD_0931 Streptococcus pneumoniae D39 hypothetical protein YP_816409.1 942890 D 373153 CDS YP_816410.1 116516641 4441430 943679..944455 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1052; equivalent gene in S.pneumoniae R6 = spr0953; hypothetical protein 944455 4441430 SPD_0932 Streptococcus pneumoniae D39 hypothetical protein YP_816410.1 943679 D 373153 CDS YP_816411.1 116516404 4442970 944383..944835 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1053; equivalent gene in S.pneumoniae R6 = spr0954; hypothetical protein 944835 4442970 SPD_0933 Streptococcus pneumoniae D39 hypothetical protein YP_816411.1 944383 D 373153 CDS YP_816412.1 116515499 4441309 945667..946026 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0955; Tn5252, ORF 10 protein 946026 4441309 SPD_0934 Streptococcus pneumoniae D39 Tn5252, ORF 10 protein YP_816412.1 945667 D 373153 CDS YP_816413.1 116517032 4442346 946036..946365 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0956; identified by match to protein family HMM PF05713; Tn5252, ORF 9 protein 946365 4442346 SPD_0935 Streptococcus pneumoniae D39 Tn5252, ORF 9 protein YP_816413.1 946036 D 373153 CDS YP_816414.1 116516207 4441467 946388..947005 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0957; identified by match to protein family HMM PF03432; Tn5252, relaxase 947005 4441467 SPD_0936 Streptococcus pneumoniae D39 Tn5252, relaxase YP_816414.1 946388 D 373153 CDS YP_816415.1 116515758 4442413 947686..948273 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0959; hypothetical protein 948273 4442413 SPD_0938 Streptococcus pneumoniae D39 hypothetical protein YP_816415.1 947686 D 373153 CDS YP_816416.1 116516388 4441594 complement(948318..949172) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0960; identified by match to protein family HMM TIGR01716; transcriptional activator, Rgg/GadR/MutR family protein 949172 4441594 SPD_0939 Streptococcus pneumoniae D39 transcriptional activator, Rgg/GadR/MutR family protein YP_816416.1 948318 R 373153 CDS YP_816417.1 116515679 4442545 949424..950719 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0961; identified by match to protein family HMM PF00984; match to protein family HMM PF03720; match to protein family HMM PF03721; UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase 950719 4442545 SPD_0940 Streptococcus pneumoniae D39 UDP-N-acetyl-D-mannosaminuronic acid dehydrogenase YP_816417.1 949424 D 373153 CDS YP_816418.1 116516558 4441263 950721..951329 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0962; hypothetical protein 951329 4441263 SPD_0941 Streptococcus pneumoniae D39 hypothetical protein YP_816418.1 950721 D 373153 CDS YP_816419.1 116515485 4442655 951339..952121 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0963; identified by match to protein family HMM PF01261; hypothetical protein 952121 4442655 SPD_0942 Streptococcus pneumoniae D39 hypothetical protein YP_816419.1 951339 D 373153 CDS YP_816420.1 116517038 4442352 952144..954036 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0964; hypothetical protein 954036 4442352 SPD_0943 Streptococcus pneumoniae D39 hypothetical protein YP_816420.1 952144 D 373153 CDS YP_816421.1 116515471 4442641 954065..955171 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0965; hypothetical protein 955171 4442641 SPD_0944 Streptococcus pneumoniae D39 hypothetical protein YP_816421.1 954065 D 373153 CDS YP_816422.1 116516531 4443082 955179..956489 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0966; identified by match to protein family HMM PF00501; AMP-binding protein 956489 4443082 SPD_0945 Streptococcus pneumoniae D39 AMP-binding protein YP_816422.1 955179 D 373153 CDS YP_816423.1 116515709 4441451 956491..957714 1 NC_008533.1 This gene has a tRNA synthetase class II core domain (G, H, P, S and T) protein equivalent gene in S.pneumoniae R6 spr0967; identified by match to protein family HMM PF00587; hypothetical protein 957714 4441451 SPD_0946 Streptococcus pneumoniae D39 hypothetical protein YP_816423.1 956491 D 373153 CDS YP_816424.1 116515898 4442777 957719..958654 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0968; hypothetical protein 958654 4442777 SPD_0947 Streptococcus pneumoniae D39 hypothetical protein YP_816424.1 957719 D 373153 CDS YP_816425.1 116516989 4442010 958669..959868 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0969; identified by match to protein family HMM PF02655; hypothetical protein 959868 4442010 SPD_0948 Streptococcus pneumoniae D39 hypothetical protein YP_816425.1 958669 D 373153 CDS YP_816426.1 116516041 4441701 959932..960531 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0970; identified by match to protein family HMM PF00132; hexapeptide repeat-containing transferase 960531 4441701 SPD_0949 Streptococcus pneumoniae D39 hexapeptide repeat-containing transferase YP_816426.1 959932 D 373153 CDS YP_816427.1 116515531 4442896 960914..962125 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0971; identified by match to protein family HMM PF07690; transporter major facilitator family protein 962125 4442896 SPD_0950 Streptococcus pneumoniae D39 transporter major facilitator family protein YP_816427.1 960914 D 373153 CDS YP_816428.1 116515940 4441342 962784..963005 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr0972; identified by match to protein family HMM PF01381; hypothetical protein 963005 4441342 SPD_0951 Streptococcus pneumoniae D39 hypothetical protein YP_816428.1 962784 D 373153 CDS YP_816429.1 116517219 4441817 963907..965136 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1067; equivalent gene in S.pneumoniae R6 = spr0973; identified by match to protein family HMM PF01098; cell division protein FtsW 965136 4441817 SPD_0952 Streptococcus pneumoniae D39 cell division protein FtsW YP_816429.1 963907 D 373153 CDS YP_816430.1 116516040 4441700 965156..967852 1 NC_008533.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase 967852 ppc 4441700 ppc Streptococcus pneumoniae D39 phosphoenolpyruvate carboxylase YP_816430.1 965156 D 373153 CDS YP_816431.1 116517122 4441894 968235..969269 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1069; equivalent gene in S.pneumoniae R6 = spr0975; identified by match to protein family HMM PF04392; hypothetical protein 969269 4441894 SPD_0954 Streptococcus pneumoniae D39 hypothetical protein YP_816431.1 968235 D 373153 CDS YP_816432.1 116515329 4442672 969338..970204 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1070; equivalent gene in S.pneumoniae R6 = spr0976; identified by match to protein family HMM PF02653; amino acid or sugar ABC transporter permease 970204 4442672 SPD_0955 Streptococcus pneumoniae D39 amino acid or sugar ABC transporter permease YP_816432.1 969338 D 373153 CDS YP_816433.1 116516417 4442983 970201..970959 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1071; equivalent gene in S.pneumoniae R6 = spr0977; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 970959 4442983 SPD_0956 Streptococcus pneumoniae D39 ABC transporter ATP-binding protein YP_816433.1 970201 D 373153 CDS YP_816434.1 116515597 4442736 971049..972809 1 NC_008533.1 synthesizes RNA primers at the replication forks; DNA primase 972809 dnaG 4442736 dnaG Streptococcus pneumoniae D39 DNA primase YP_816434.1 971049 D 373153 CDS YP_816435.1 116516638 4441427 972812..973921 1 NC_008533.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; primary sigma factor of bacterium; RNA polymerase sigma factor RpoD 973921 rpoD 4441427 rpoD Streptococcus pneumoniae D39 RNA polymerase sigma factor RpoD YP_816435.1 972812 D 373153 CDS YP_816436.1 116516796 4442191 973935..974264 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1074; equivalent gene in S.pneumoniae R6 = spr0980; identified by match to protein family HMM PF01883; hypothetical protein 974264 4442191 SPD_0959 Streptococcus pneumoniae D39 hypothetical protein YP_816436.1 973935 D 373153 CDS YP_816437.1 116516765 4442276 974298..975422 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1075; equivalent gene in S.pneumoniae R6 = spr0981; identified by match to protein family HMM PF00534; glycosyl transferase CpoA 975422 cpoA 4442276 cpoA Streptococcus pneumoniae D39 glycosyl transferase CpoA YP_816437.1 974298 D 373153 CDS YP_816438.1 116515479 4442649 975438..976763 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1076; equivalent gene in S.pneumoniae R6 = spr0982; identified by match to protein family HMM PF00534; group 1 glycosyl transferase 976763 4442649 SPD_0961 Streptococcus pneumoniae D39 group 1 glycosyl transferase YP_816438.1 975438 D 373153 CDS YP_816439.1 116516478 4443007 976794..976970 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1077; equivalent gene in S.pneumoniae R6 = spr0983; identified by match to protein family HMM PF04024; hypothetical protein 976970 4443007 SPD_0962 Streptococcus pneumoniae D39 hypothetical protein YP_816439.1 976794 D 373153 CDS YP_816440.1 116516165 4442839 977029..977163 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1078; hypothetical protein 977163 4442839 SPD_0963 Streptococcus pneumoniae D39 hypothetical protein YP_816440.1 977029 D 373153 CDS YP_816441.1 116515321 4442664 977227..978537 1 NC_008533.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 978537 obgE 4442664 obgE Streptococcus pneumoniae D39 GTPase ObgE YP_816441.1 977227 D 373153 CDS YP_816442.1 116516023 4441585 978547..978705 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1080; equivalent gene in S.pneumoniae R6 = spr0985; hypothetical protein 978705 4441585 SPD_0965 Streptococcus pneumoniae D39 hypothetical protein YP_816442.1 978547 D 373153 CDS YP_816443.1 116515884 4441381 981327..982586 1 NC_008533.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 982586 murA-1 4441381 murA-1 Streptococcus pneumoniae D39 UDP-N-acetylglucosamine 1-carboxyvinyltransferase YP_816443.1 981327 D 373153 CDS YP_816444.1 116516477 4443006 982602..983153 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1082; equivalent gene in S.pneumoniae R6 = spr0990; identified by match to protein family HMM PF00583; GNAT family acetyltransferase 983153 4443006 SPD_0968 Streptococcus pneumoniae D39 GNAT family acetyltransferase YP_816444.1 982602 D 373153 CDS YP_816445.1 116517139 4442377 983146..984423 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1083; equivalent gene in S.pneumoniae R6 = spr0991; identified by match to protein family HMM PF00571; match to protein family HMM PF03061; match to protein family HMM PF07085; hypothetical protein 984423 4442377 SPD_0969 Streptococcus pneumoniae D39 hypothetical protein YP_816445.1 983146 D 373153 CDS YP_816446.1 116516526 4443077 984439..985299 1 NC_008533.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; methionine aminopeptidase 985299 map 4443077 map Streptococcus pneumoniae D39 methionine aminopeptidase YP_816446.1 984439 D 373153 CDS YP_816447.1 116515413 4442483 985680..986078 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1310; equivalent gene in S.pneumoniae R6 = spr0993; IS1381, transposase OrfA 986078 4442483 SPD_0971 Streptococcus pneumoniae D39 IS1381, transposase OrfA YP_816447.1 985680 D 373153 CDS YP_816448.1 116516586 4442110 986093..986482 1 NC_008533.1 IS1381, transposase OrfB 986482 4442110 SPD_0972 Streptococcus pneumoniae D39 IS1381, transposase OrfB YP_816448.1 986093 D 373153 CDS YP_816449.1 116515714 4442251 986673..988964 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1087; equivalent gene in S.pneumoniae R6 = spr0995; identified by match to protein family HMM PF00580; match to protein family HMM TIGR01073; ATP-dependent DNA helicase PcrA 988964 pcrA 4442251 pcrA Streptococcus pneumoniae D39 ATP-dependent DNA helicase PcrA YP_816449.1 986673 D 373153 CDS YP_816450.1 116516612 4442389 989007..989687 1 NC_008533.1 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase; DNA repair protein RadC 989687 radC 4442389 radC Streptococcus pneumoniae D39 DNA repair protein RadC YP_816450.1 989007 D 373153 CDS YP_816451.1 116517015 4441960 complement(989684..990373) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1089; equivalent gene in S.pneumoniae R6 = spr0997; identified by match to protein family HMM PF00117; match to protein family HMM PF07722; class I glutamine amidotransferase 990373 4441960 SPD_0974 Streptococcus pneumoniae D39 class I glutamine amidotransferase YP_816451.1 989684 R 373153 CDS YP_816452.1 116515408 4442478 complement(990391..991032) 1 NC_008533.1 modulates transcription in response to the NADH/NAD(+) redox state; redox-sensing transcriptional repressor Rex 991032 4442478 SPD_0976 Streptococcus pneumoniae D39 redox-sensing transcriptional repressor Rex YP_816452.1 990391 R 373153 CDS YP_816453.1 116516287 4442615 complement(991115..991366) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1092; equivalent gene in S.pneumoniae R6 = spr0999; hypothetical protein 991366 4442615 SPD_0977 Streptococcus pneumoniae D39 hypothetical protein YP_816453.1 991115 R 373153 CDS YP_816454.1 116515573 4442883 complement(991338..991685) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1093; equivalent gene in S.pneumoniae R6 = spr1000; hypothetical protein 991685 4442883 SPD_0978 Streptococcus pneumoniae D39 hypothetical protein YP_816454.1 991338 R 373153 CDS YP_816455.1 116515455 4441180 complement(991690..992805) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1094; equivalent gene in S.pneumoniae R6 = spr1001; identified by match to protein family HMM PF00266; class V aminotransferase 992805 4441180 SPD_0979 Streptococcus pneumoniae D39 class V aminotransferase YP_816455.1 991690 R 373153 CDS YP_816456.1 116517035 4442349 complement(992815..993774) 1 NC_008533.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 993774 prs2 4442349 prs2 Streptococcus pneumoniae D39 ribose-phosphate pyrophosphokinase YP_816456.1 992815 R 373153 CDS YP_816457.1 116516210 4441470 complement(993887..994456) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1096; equivalent gene in S.pneumoniae R6 = spr1003; identified by match to protein family HMM PF01928; hypothetical protein 994456 4441470 SPD_0981 Streptococcus pneumoniae D39 hypothetical protein YP_816457.1 993887 R 373153 CDS YP_816458.1 116515750 4442405 994584..995255 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1097; equivalent gene in S.pneumoniae R6 = spr1004 This protein has been crystalized; identified by match to protein family HMM PF04607; pyrophosphokinase family protein 995255 4442405 SPD_0982 Streptococcus pneumoniae D39 pyrophosphokinase family protein YP_816458.1 994584 D 373153 CDS YP_816459.1 116515865 4441101 995239..996057 1 NC_008533.1 catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 996057 ppnK 4441101 ppnK Streptococcus pneumoniae D39 inorganic polyphosphate/ATP-NAD kinase YP_816459.1 995239 D 373153 CDS YP_816460.1 116516162 4442836 996054..996950 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1099; equivalent gene in S.pneumoniae R6 = spr1006; identified by match to protein family HMM PF00849; match to protein family HMM TIGR00005; ribosomal large subunit pseudouridine synthase, RluD subfamily protein 996950 4442836 SPD_0984 Streptococcus pneumoniae D39 ribosomal large subunit pseudouridine synthase, RluD subfamily protein YP_816460.1 996054 D 373153 CDS YP_816461.1 116516290 4442579 996994..997968 1 NC_008533.1 in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta; phosphotransacetylase 997968 eutD 4442579 eutD Streptococcus pneumoniae D39 phosphotransacetylase YP_816461.1 996994 D 373153 CDS YP_816462.1 116516611 4442388 complement(999729..1000028) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1102; equivalent gene in S.pneumoniae R6 = spr1010; identified by match to protein family HMM PF02575; match to protein family HMM TIGR00103; hypothetical protein 1000028 4442388 SPD_0987 Streptococcus pneumoniae D39 hypothetical protein YP_816462.1 999729 R 373153 CDS YP_816463.1 116516853 4442134 1000430..1001134 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1104; equivalent gene in S.pneumoniae R6 = spr1011; identified by match to protein family HMM PF06912; hypothetical protein 1001134 4442134 SPD_0988 Streptococcus pneumoniae D39 hypothetical protein YP_816463.1 1000430 D 373153 CDS YP_816464.1 116516747 4442297 1001316..1001630 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1105; equivalent gene in S.pneumoniae R6 = spr1012; identified by match to protein family HMM PF00829; match to protein family HMM TIGR00061; 50S ribosomal protein L21 1001630 rplU 4442297 rplU Streptococcus pneumoniae D39 50S ribosomal protein L21 YP_816464.1 1001316 D 373153 CDS YP_816465.1 116515440 4441287 1001646..1001990 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1106; equivalent gene in S.pneumoniae R6 = spr1013; identified by match to protein family HMM PF04327; hypothetical protein 1001990 4441287 SPD_0990 Streptococcus pneumoniae D39 hypothetical protein YP_816465.1 1001646 D 373153 CDS YP_816466.1 116515463 4441188 1002007..1002300 1 NC_008533.1 involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 1002300 rpmA 4441188 rpmA Streptococcus pneumoniae D39 50S ribosomal protein L27 YP_816466.1 1002007 D 373153 CDS YP_816467.1 116516406 4442972 complement(1002646..1002816) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1108; equivalent gene in S.pneumoniae R6 = spr1015; hypothetical protein 1002816 4442972 SPD_0992 Streptococcus pneumoniae D39 hypothetical protein YP_816467.1 1002646 R 373153 CDS YP_816468.1 116516220 4441480 complement(1002788..1002916) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1109; hypothetical protein 1002916 4441480 SPD_0993 Streptococcus pneumoniae D39 hypothetical protein YP_816468.1 1002788 R 373153 CDS YP_816469.1 116517107 4441879 1003253..1004170 1 NC_008533.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 1004170 ribF 4441879 ribF Streptococcus pneumoniae D39 bifunctional riboflavin kinase/FMN adenylyltransferase YP_816469.1 1003253 D 373153 CDS YP_816470.1 116516022 4441584 complement(1004263..1005111) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1111; equivalent gene in S.pneumoniae R6 = spr1018; identified by match to protein family HMM PF02588; hypothetical protein 1005111 4441584 SPD_0995 Streptococcus pneumoniae D39 hypothetical protein YP_816470.1 1004263 R 373153 CDS YP_816471.1 116517176 4441852 1005253..1006092 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1112; equivalent gene in S.pneumoniae R6 = spr1019; identified by match to protein family HMM PF02645; match to protein family HMM TIGR00762; DegV family protein 1006092 4441852 SPD_0996 Streptococcus pneumoniae D39 DegV family protein YP_816471.1 1005253 D 373153 CDS YP_816472.1 116516205 4441465 1006198..1006473 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1113; equivalent gene in S.pneumoniae R6 = spr1020; identified by match to protein family HMM PF00216; DNA-binding protein HU 1006473 hup 4441465 hup Streptococcus pneumoniae D39 DNA-binding protein HU YP_816472.1 1006198 D 373153 CDS YP_816473.1 116516774 4442227 1006899..1008800 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1114; equivalent gene in S.pneumoniae R6 = spr1021; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1008800 4442227 SPD_0998 Streptococcus pneumoniae D39 ABC transporter ATP-binding protein YP_816473.1 1006899 D 373153 CDS YP_816474.1 116516782 4442235 1008803..1009666 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1115; equivalent gene in S.pneumoniae R6 = spr1022; identified by match to protein family HMM TIGR01716; transcriptional regulator MutR 1009666 4442235 SPD_0999 Streptococcus pneumoniae D39 transcriptional regulator MutR YP_816474.1 1008803 D 373153 CDS YP_816475.1 116515698 4441440 1009746..1010924 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1116; equivalent gene in S.pneumoniae R6 = spr1023; identified by match to protein family HMM PF07690; transporter major facilitator family protein 1010924 4441440 SPD_1000 Streptococcus pneumoniae D39 transporter major facilitator family protein YP_816475.1 1009746 D 373153 CDS YP_816476.1 116516470 4442940 1011017..1012975 1 NC_008533.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA 1012975 ligA 4442940 ligA Streptococcus pneumoniae D39 NAD-dependent DNA ligase LigA YP_816476.1 1011017 D 373153 CDS YP_816477.1 116515362 4441162 1013087..1015366 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1118; equivalent gene in S.pneumoniae R6 = spr1025; identified by match to protein family HMM PF00128; match to protein family HMM PF02922; match to protein family HMM TIGR02104; pullulanase 1015366 pulA 4441162 pulA Streptococcus pneumoniae D39 pullulanase YP_816477.1 1013087 D 373153 CDS YP_816478.1 116515690 4442556 complement(1015718..1015891) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1027; hypothetical protein 1015891 4442556 SPD_1003 Streptococcus pneumoniae D39 hypothetical protein YP_816478.1 1015718 R 373153 CDS YP_816479.1 116516523 4443074 1015910..1017334 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1119; equivalent gene in S.pneumoniae R6 = spr1028; identified by match to protein family HMM PF00171; glyceraldehyde-3-phosphate dehydrogenase 1017334 gapN 4443074 gapN Streptococcus pneumoniae D39 glyceraldehyde-3-phosphate dehydrogenase YP_816479.1 1015910 D 373153 CDS YP_816480.1 116517137 4442375 1017799..1019727 1 NC_008533.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching protein 1019727 glgB 4442375 glgB Streptococcus pneumoniae D39 glycogen branching protein YP_816480.1 1017799 D 373153 CDS YP_816481.1 116516326 4442809 1019717..1020859 1 NC_008533.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 1020859 glgC 4442809 glgC Streptococcus pneumoniae D39 glucose-1-phosphate adenylyltransferase YP_816481.1 1019717 D 373153 CDS YP_816482.1 116516261 4441771 1020849..1021988 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1123; equivalent gene in S.pneumoniae R6 = spr1031; identified by match to protein family HMM PF00483; match to protein family HMM TIGR02092; glucose-1-phosphate adenylyltransferase, GlgD subunit 1021988 glgD 4441771 glgD Streptococcus pneumoniae D39 glucose-1-phosphate adenylyltransferase, GlgD subunit YP_816482.1 1020849 D 373153 CDS YP_816483.1 116516483 4443012 1021985..1023418 1 NC_008533.1 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose; glycogen synthase 1023418 glgA 4443012 glgA Streptococcus pneumoniae D39 glycogen synthase YP_816483.1 1021985 D 373153 CDS YP_816484.1 116515367 4441167 1024131..1025246 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1126; equivalent gene in S.pneumoniae R6 = spr1034; identified by match to protein family HMM PF02595; match to protein family HMM TIGR00045; glycerate kinase 1025246 4441167 SPD_1011 Streptococcus pneumoniae D39 glycerate kinase YP_816484.1 1024131 D 373153 CDS YP_816485.1 116517193 4441830 complement(1025243..1025689) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1127; equivalent gene in S.pneumoniae R6 = spr1035; identified by match to protein family HMM PF07997; hypothetical protein 1025689 4441830 SPD_1010 Streptococcus pneumoniae D39 hypothetical protein YP_816485.1 1025243 R 373153 CDS YP_816486.1 116516768 4442279 1025853..1027157 1 NC_008533.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 1027157 eno 4442279 eno Streptococcus pneumoniae D39 phosphopyruvate hydratase YP_816486.1 1025853 D 373153 CDS YP_816487.1 116515952 4441393 complement(1027295..1027741) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1147; identified by match to protein family HMM PF00589; integrase/recombinase, phage integrase family protein 1027741 4441393 SPD_1013 Streptococcus pneumoniae D39 integrase/recombinase, phage integrase family protein YP_816487.1 1027295 R 373153 CDS YP_816488.1 116515851 4441543 complement(1028138..1028488) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0299; equivalent gene in S.pneumoniae R6 = spr1038 In TIGR4 this gene is annotated as a truncation; however in R6 there are numerous near perfect copies as well as copies with a slightly longer version with a different end that is not present in either R6 or TIGR4 This indicates it may still function as a transposase; identified by match to protein family HMM PF01710; IS630-Spn1, transposase Orf1 1028488 4441543 SPD_1014 Streptococcus pneumoniae D39 IS630-Spn1, transposase Orf1 YP_816488.1 1028138 R 373153 CDS YP_816489.1 116516958 4442911 1028989..1032288 1 NC_008533.1 RexAB system found in Gram positive bacteria appears to fulfill the biological roles of RecBCD found in Gram negative bacteria. equivalent gene in S.pneumoniae TIGR4 = SP1151; equivalent gene in S.pneumoniae R6 = spr1039; identified by match to protein family HMM TIGR02774; ATP-dependent exonuclease RexB 1032288 rexB 4442911 rexB Streptococcus pneumoniae D39 ATP-dependent exonuclease RexB YP_816489.1 1028989 D 373153 CDS YP_816490.1 116515444 4441291 1032285..1035935 1 NC_008533.1 RexAB system found in Gram positive bacteria appears to fulfill the biological roles of RecBCD found in Gram negative bacteria. equivalent gene in S.pneumoniae TIGR4 = SP1152; equivalent gene in S.pneumoniae R6 = spr1040; identified by match to protein family HMM PF00580; match to protein family HMM TIGR02785; exonuclease RexA 1035935 rexA 4441291 rexA Streptococcus pneumoniae D39 exonuclease RexA YP_816490.1 1032285 D 373153 CDS YP_816491.1 116517013 4441958 1036105..1037283 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1153; equivalent gene in S.pneumoniae R6 = spr1041; hypothetical protein 1037283 4441958 SPD_1017 Streptococcus pneumoniae D39 hypothetical protein YP_816491.1 1036105 D 373153 CDS YP_816492.1 116516343 4442828 1037492..1043383 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1042; identified by match to protein family HMM PF00746; match to protein family HMM PF04650; match to protein family HMM PF05342; match to protein family HMM PF07501; match to protein family HMM PF07580; match to protein family HMM PF07581; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; immunoglobulin A1 protease 1043383 iga 4442828 iga Streptococcus pneumoniae D39 immunoglobulin A1 protease YP_816492.1 1037492 D 373153 CDS YP_816493.1 116515446 4441293 1043842..1044693 1 NC_008533.1 essential GTPase; functions in ribosome assembly; binds a unique part of the 23S rRNA; interacts with ribosomal protein L25(Ctc); ribosomal biogenesis GTPase 1044693 rbgA 4441293 rbgA Streptococcus pneumoniae D39 ribosomal biogenesis GTPase YP_816493.1 1043842 D 373153 CDS YP_816494.1 116515974 4442425 1044680..1045459 1 NC_008533.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 1045459 rnhB 4442425 rnhB Streptococcus pneumoniae D39 ribonuclease HII YP_816494.1 1044680 D 373153 CDS YP_816495.1 116517148 4441862 1045475..1047025 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1157; equivalent gene in S.pneumoniae R6 = spr1045; identified by match to protein family HMM PF00654; match to protein family HMM PF02080; voltage-gated chloride channel family protein 1047025 4441862 SPD_1021 Streptococcus pneumoniae D39 voltage-gated chloride channel family protein YP_816495.1 1045475 D 373153 CDS YP_816496.1 116516962 4442915 complement(1047218..1047331) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1158; hypothetical protein 1047331 4442915 SPD_1022 Streptococcus pneumoniae D39 hypothetical protein YP_816496.1 1047218 R 373153 CDS YP_816497.1 116516164 4442838 1047609..1048679 1 NC_008533.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerS; site-specific tyrosine recombinase XerS 1048679 xerS 4442838 xerS Streptococcus pneumoniae D39 site-specific tyrosine recombinase XerS YP_816497.1 1047609 D 373153 CDS YP_816498.1 116516751 4442301 complement(1048752..1049741) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1160; equivalent gene in S.pneumoniae R6 = spr1047; identified by match to protein family HMM PF03099; match to protein family HMM TIGR00545; lipoate-protein ligase 1049741 4442301 SPD_1024 Streptococcus pneumoniae D39 lipoate-protein ligase YP_816498.1 1048752 R 373153 CDS YP_816499.1 116515652 4441333 complement(1049805..1051490) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1161; equivalent gene in S.pneumoniae R6 = spr1048; identified by match to protein family HMM PF00070; match to protein family HMM PF00364; match to protein family HMM PF01134; match to protein family HMM PF02852; match to protein family HMM PF03486; match to protein family HMM PF07992; match to protein family HMM TIGR01350; dihydrolipoamide dehydrogenase 1051490 lpdA 4441333 lpdA Streptococcus pneumoniae D39 dihydrolipoamide dehydrogenase YP_816499.1 1049805 R 373153 CDS YP_816500.1 116515407 4442477 complement(1051554..1052597) 1 NC_008533.1 unlike PdhC proteins from other organisms, some Mycoplasma lack an N-terminal lipoyl domain; in Mycoplasma hyopneumonia the PdhD proteins contains the lipoyl domain; dihydrolipoamide acetyltransferase 1052597 4442477 SPD_1026 Streptococcus pneumoniae D39 dihydrolipoamide acetyltransferase YP_816500.1 1051554 R 373153 CDS YP_816501.1 116516741 4442291 complement(1052815..1053807) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1163; equivalent gene in S.pneumoniae R6 = spr1050; identified by match to protein family HMM PF02779; match to protein family HMM PF02780; acetoin dehydrogenase, E1 component subunit beta 1053807 4442291 SPD_1027 Streptococcus pneumoniae D39 acetoin dehydrogenase, E1 component subunit beta YP_816501.1 1052815 R 373153 CDS YP_816502.1 116516204 4441464 complement(1053823..1054791) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1164; equivalent gene in S.pneumoniae R6 = spr1051; identified by match to protein family HMM PF00676; TPP-dependent acetoin dehydrogenase subunit alpha 1054791 acoA 4441464 acoA Streptococcus pneumoniae D39 TPP-dependent acetoin dehydrogenase subunit alpha YP_816502.1 1053823 R 373153 CDS YP_816503.1 116517066 4441954 complement(1054945..1056306) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1166; equivalent gene in S.pneumoniae R6 = spr1052; identified by match to protein family HMM PF01554; match to protein family HMM TIGR00797; MATE efflux family protein 1056306 4441954 SPD_1029 Streptococcus pneumoniae D39 MATE efflux family protein YP_816503.1 1054945 R 373153 CDS YP_816504.1 116515810 4442857 complement(1056591..1057859) 1 NC_008533.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase 1057859 pyrC 4442857 pyrC Streptococcus pneumoniae D39 dihydroorotase YP_816504.1 1056591 R 373153 CDS YP_816505.1 116515668 4441251 complement(1057872..1058336) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1168; equivalent gene in S.pneumoniae R6 = spr1054; identified by match to protein family HMM PF00293; Mutator mutT protein (7,8-dihydro-8-oxoguanine-triphosphatase) (8-oxo-dGTPase) 1058336 mutX 4441251 mutX Streptococcus pneumoniae D39 Mutator mutT protein (7,8-dihydro-8-oxoguanine-triphosphatase) (8-oxo-dGTPase) YP_816505.1 1057872 R 373153 CDS YP_816506.1 116516721 4442309 complement(1058346..1058999) 1 NC_008533.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 1058999 ung 4442309 ung Streptococcus pneumoniae D39 uracil-DNA glycosylase YP_816506.1 1058346 R 373153 CDS YP_816507.1 116515370 4441170 complement(1059135..1059782) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1170; equivalent gene in S.pneumoniae R6 = spr1056; hypothetical protein 1059782 4441170 SPD_1033 Streptococcus pneumoniae D39 hypothetical protein YP_816507.1 1059135 R 373153 CDS YP_816508.1 116516454 4442574 complement(1059796..1060509) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1171; equivalent gene in S.pneumoniae R6 = spr1057; identified by match to protein family HMM PF00702; match to protein family HMM TIGR01549; match to protein family HMM TIGR02254; hydrolase 1060509 4442574 SPD_1034 Streptococcus pneumoniae D39 hydrolase YP_816508.1 1059796 R 373153 CDS YP_816509.1 116516248 4441528 complement(1060967..1061125) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1173; equivalent gene in S.pneumoniae R6 = spr1058; hypothetical protein 1061125 4441528 SPD_1035 Streptococcus pneumoniae D39 hypothetical protein YP_816509.1 1060967 R 373153 CDS YP_816510.1 116516920 4442069 complement(1061195..1061347) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1059; hypothetical protein 1061347 4442069 SPD_1036 Streptococcus pneumoniae D39 hypothetical protein YP_816510.1 1061195 R 373153 CDS YP_816511.1 116515840 4441531 complement(1061769..1064303) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1060; identified by match to protein family HMM PF04270; match to protein family HMM TIGR01363; histidine triad protein 1064303 4441531 SPD_1037 Streptococcus pneumoniae D39 histidine triad protein YP_816511.1 1061769 R 373153 CDS YP_816512.1 116517004 4441988 complement(1064461..1066911) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1175; equivalent gene in S.pneumoniae R6 = spr1061; identified by match to protein family HMM PF04270; match to protein family HMM TIGR01363; histidine triad protein A 1066911 phpA 4441988 phpA Streptococcus pneumoniae D39 histidine triad protein A YP_816512.1 1064461 R 373153 CDS YP_816513.1 116515883 4441380 complement(1067166..1068899) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1176; equivalent gene in S.pneumoniae R6 = spr1062; identified by match to protein family HMM PF00391; match to protein family HMM PF02896; match to protein family HMM PF05524; match to protein family HMM TIGR01417; phosphoenolpyruvate-protein phosphotransferase 1068899 ptsI 4441380 ptsI Streptococcus pneumoniae D39 phosphoenolpyruvate-protein phosphotransferase YP_816513.1 1067166 R 373153 CDS YP_816514.1 116516713 4442339 complement(1068905..1069168) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1177; equivalent gene in S.pneumoniae R6 = spr1063; identified by match to protein family HMM PF00381; match to protein family HMM TIGR01003; phosphocarrier protein HPr 1069168 ptsH 4442339 ptsH Streptococcus pneumoniae D39 phosphocarrier protein HPr YP_816514.1 1068905 R 373153 CDS YP_816515.1 116516941 4442017 1069519..1069737 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1178; equivalent gene in S.pneumoniae R6 = spr1064; identified by match to protein family HMM PF00462; match to protein family HMM TIGR02194; glutaredoxin-like protein NrdH 1069737 nrdH 4442017 nrdH Streptococcus pneumoniae D39 glutaredoxin-like protein NrdH YP_816515.1 1069519 D 373153 CDS YP_816516.1 116516073 4442530 1069818..1071977 1 NC_008533.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 1071977 nrdE 4442530 nrdE Streptococcus pneumoniae D39 ribonucleotide-diphosphate reductase subunit alpha YP_816516.1 1069818 D 373153 CDS YP_816517.1 116517162 4441876 1072165..1073127 1 NC_008533.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 1073127 nrdF 4441876 nrdF Streptococcus pneumoniae D39 ribonucleotide-diphosphate reductase subunit beta YP_816517.1 1072165 D 373153 CDS YP_816518.1 116516466 4442936 1073309..1074070 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1182; equivalent gene in S.pneumoniae R6 = spr1067; identified by match to protein family HMM PF00455; match to protein family HMM PF08220; lactose phosphotransferase system repressor 1074070 lacR2 4442936 lacR2 Streptococcus pneumoniae D39 lactose phosphotransferase system repressor YP_816518.1 1073309 D 373153 CDS YP_816519.1 116515662 4441245 complement(1074340..1074525) 1 NC_008533.1 hypothetical protein 1074525 4441245 SPD_1045 Streptococcus pneumoniae D39 hypothetical protein YP_816519.1 1074340 R 373153 CDS YP_816520.1 116516678 4442459 complement(1074568..1075974) 1 NC_008533.1 catalyzes the formation of 6-phospho-galactose from a 6-phospho-beta-galactoside; 6-phospho-beta-galactosidase 1075974 lacG-2 4442459 lacG-2 Streptococcus pneumoniae D39 6-phospho-beta-galactosidase YP_816520.1 1074568 R 373153 CDS YP_816521.1 116515590 4441210 complement(1076183..1077874) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1185; equivalent gene in S.pneumoniae R6 = spr1070; identified by match to protein family HMM PF02302; match to protein family HMM PF02378; match to protein family HMM TIGR00394; match to protein family HMM TIGR00410; match to protein family HMM TIGR00853; PTS system lactose-specific transporter subunit IIBC 1077874 lacE-2 4441210 lacE-2 Streptococcus pneumoniae D39 PTS system lactose-specific transporter subunit IIBC YP_816521.1 1076183 R 373153 CDS YP_816522.1 116516599 4441229 complement(1077874..1078191) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1186; equivalent gene in S.pneumoniae R6 = spr1071; identified by match to protein family HMM PF02255; match to protein family HMM TIGR00823; PTS system lactose-specific transporter subunit IIA 1078191 lacF-2 4441229 lacF-2 Streptococcus pneumoniae D39 PTS system lactose-specific transporter subunit IIA YP_816522.1 1077874 R 373153 CDS YP_816523.1 116517211 4441809 complement(1078227..1079063) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1187; equivalent gene in S.pneumoniae R6 = spr1072; identified by match to protein family HMM PF00874; match to protein family HMM PF03123; transcription antiterminator LacT 1079063 lacT 4441809 lacT Streptococcus pneumoniae D39 transcription antiterminator LacT YP_816523.1 1078227 R 373153 CDS YP_816524.1 116516368 4443030 complement(1079297..1080277) 1 NC_008533.1 catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in Streptococcus pyogenes there are two paralogs of tagatose-bisphosphate aldolase, encoded by lacD1 and lacD2; expression of lacD1 is highly regulated by environmental conditions while lacD2 specializes in an efficient utilization of carbohydrate sources; tagatose 1,6-diphosphate aldolase 1080277 lacD 4443030 lacD Streptococcus pneumoniae D39 tagatose 1,6-diphosphate aldolase YP_816524.1 1079297 R 373153 CDS YP_816525.1 116516039 4441699 complement(1080279..1081208) 1 NC_008533.1 catalyzes the formation of tagatose 1,6-bisphosphate from tagatose 6-phosphate and ATP; tagatose-6-phosphate kinase 1081208 lacC 4441699 lacC Streptococcus pneumoniae D39 tagatose-6-phosphate kinase YP_816525.1 1080279 R 373153 CDS YP_816526.1 116517129 4442367 complement(1081219..1081734) 1 NC_008533.1 catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; galactose-6-phosphate isomerase subunit LacB 1081734 lacB 4442367 lacB Streptococcus pneumoniae D39 galactose-6-phosphate isomerase subunit LacB YP_816526.1 1081219 R 373153 CDS YP_816527.1 116515890 4441388 complement(1081765..1082190) 1 NC_008533.1 catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; tagatose pathway for galactose utilization; galactose-6-phosphate isomerase subunit LacA 1082190 lacA 4441388 lacA Streptococcus pneumoniae D39 galactose-6-phosphate isomerase subunit LacA YP_816527.1 1081765 R 373153 CDS YP_816528.1 116516900 4442085 complement(1082348..1082692) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1194; equivalent gene in S.pneumoniae R6 = spr1077; hypothetical protein 1082692 4442085 SPD_1054 Streptococcus pneumoniae D39 hypothetical protein YP_816528.1 1082348 R 373153 CDS YP_816529.1 116516547 4441051 complement(1083671..1083973) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1197; equivalent gene in S.pneumoniae R6 = spr1080; PTS system transporter subunit IIB 1083973 4441051 SPD_1057 Streptococcus pneumoniae D39 PTS system transporter subunit IIB YP_816529.1 1083671 R 373153 CDS YP_816530.1 116516787 4442240 1084667..1084819 1 NC_008533.1 hypothetical protein 1084819 4442240 SPD_1059 Streptococcus pneumoniae D39 hypothetical protein YP_816530.1 1084667 D 373153 CDS YP_816531.1 116516228 4441488 complement(1084900..1086723) 1 NC_008533.1 binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 1086723 lepA 4441488 lepA Streptococcus pneumoniae D39 GTP-binding protein LepA YP_816531.1 1084900 R 373153 CDS YP_816532.1 116516467 4442937 complement(1086802..1087530) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1201; equivalent gene in S.pneumoniae R6 = spr1083; identified by match to protein family HMM PF00149; serine/threonine protein phosphatase 1087530 4442937 SPD_1061 Streptococcus pneumoniae D39 serine/threonine protein phosphatase YP_816532.1 1086802 R 373153 CDS YP_816533.1 116516837 4442157 complement(1087532..1089199) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1202; equivalent gene in S.pneumoniae R6 = spr1084; identified by match to protein family HMM PF02463; match to protein family HMM TIGR00634; DNA repair protein RecN 1089199 recN 4442157 recN Streptococcus pneumoniae D39 DNA repair protein RecN YP_816533.1 1087532 R 373153 CDS YP_816534.1 116515743 4441032 complement(1089206..1089637) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1203; equivalent gene in S.pneumoniae R6 = spr1085; identified by match to protein family HMM PF01316; match to protein family HMM PF02863; transcriptional regulator of arginine metabolism expression 1089637 4441032 SPD_1063 Streptococcus pneumoniae D39 transcriptional regulator of arginine metabolism expression YP_816534.1 1089206 R 373153 CDS YP_816535.1 116516842 4442162 complement(1089630..1090445) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1204; equivalent gene in S.pneumoniae R6 = spr1086; identified by match to protein family HMM PF01479; match to protein family HMM PF01728; match to protein family HMM TIGR00478; hemolysin A 1090445 4442162 SPD_1064 Streptococcus pneumoniae D39 hemolysin A YP_816535.1 1089630 R 373153 CDS YP_816536.1 116516004 4441508 complement(1090438..1091313) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1205; equivalent gene in S.pneumoniae R6 = spr1087; identified by match to protein family HMM PF00348; geranyltranstransferase 1091313 ispA 4441508 ispA Streptococcus pneumoniae D39 geranyltranstransferase YP_816536.1 1090438 R 373153 CDS YP_816537.1 116516524 4443075 complement(1091310..1091522) 1 NC_008533.1 catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit 1091522 xseB 4443075 xseB Streptococcus pneumoniae D39 exodeoxyribonuclease VII small subunit YP_816537.1 1091310 R 373153 CDS YP_816538.1 116515460 4441185 complement(1091500..1092840) 1 NC_008533.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 1092840 xseA 4441185 xseA Streptococcus pneumoniae D39 exodeoxyribonuclease VII large subunit YP_816538.1 1091500 R 373153 CDS YP_816539.1 116516339 4442822 complement(1092968..1093606) 1 NC_008533.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase 1093606 udk 4442822 udk Streptococcus pneumoniae D39 uridine kinase YP_816539.1 1092968 R 373153 CDS YP_816540.1 116515672 4441255 complement(1093714..1094016) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1210; equivalent gene in S.pneumoniae R6 = spr1091; hypothetical protein 1094016 4441255 SPD_1069 Streptococcus pneumoniae D39 hypothetical protein YP_816540.1 1093714 R 373153 CDS YP_816541.1 116515728 4441016 complement(1094257..1095135) 1 NC_008533.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B 1095135 truB 4441016 truB Streptococcus pneumoniae D39 tRNA pseudouridine synthase B YP_816541.1 1094257 R 373153 CDS YP_816542.1 116516569 4441274 complement(1095236..1098421) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1093; hypothetical protein 1098421 4441274 SPD_1071 Streptococcus pneumoniae D39 hypothetical protein YP_816542.1 1095236 R 373153 CDS YP_816543.1 116515946 4441348 complement(1098433..1099707) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1213; equivalent gene in S.pneumoniae R6 = spr1094; hypothetical protein 1099707 4441348 SPD_1072 Streptococcus pneumoniae D39 hypothetical protein YP_816543.1 1098433 R 373153 CDS YP_816544.1 116516807 4442203 complement(1099803..1100918) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1095; identified by match to protein family HMM PF01053; match to protein family HMM PF01212; match to protein family HMM TIGR01326; O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase 1100918 4442203 SPD_1073 Streptococcus pneumoniae D39 O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase YP_816544.1 1099803 R 373153 CDS YP_816545.1 116516884 4442127 complement(1100940..1101062) 1 NC_008533.1 similar to a domain of the O-acetylhomoserine sulfhydrylase characterized in Leptospira meyeri. equivalent gene in S.pneumoniae R6 = spr1096; hypothetical protein 1101062 4442127 SPD_1074 Streptococcus pneumoniae D39 hypothetical protein YP_816545.1 1100940 R 373153 CDS YP_816546.1 116516152 4442514 complement(1101210..1102007) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1215; equivalent gene in S.pneumoniae R6 = spr1097; identified by match to protein family HMM PF01226; transporter FNT family protein 1102007 4442514 SPD_1075 Streptococcus pneumoniae D39 transporter FNT family protein YP_816546.1 1101210 R 373153 CDS YP_816547.1 116515518 4442999 complement(1102251..1102994) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1218; equivalent gene in S.pneumoniae R6 = spr1098; identified by match to protein family HMM PF04203; match to protein family HMM TIGR01076; sortase 1102994 srtA 4442999 srtA Streptococcus pneumoniae D39 sortase YP_816547.1 1102251 R 373153 CDS YP_816548.1 116516676 4442457 complement(1102994..1105462) 1 NC_008533.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A 1105462 gyrA 4442457 gyrA Streptococcus pneumoniae D39 DNA gyrase subunit A YP_816548.1 1102994 R 373153 CDS YP_816549.1 116515602 4442741 1105656..1106642 1 NC_008533.1 Converts (S)-lactate and NAD(+) to pyruvate and NADH; L-lactate dehydrogenase 1106642 ldh 4442741 ldh Streptococcus pneumoniae D39 L-lactate dehydrogenase YP_816549.1 1105656 D 373153 CDS YP_816550.1 116516375 4443037 complement(1107028..1110282) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1221; equivalent gene in S.pneumoniae R6 = spr1101; identified by match to protein family HMM PF04851; type II restriction endonuclease 1110282 4443037 SPD_1079 Streptococcus pneumoniae D39 type II restriction endonuclease YP_816550.1 1107028 R 373153 CDS YP_816551.1 116515779 4441679 complement(1110447..1112318) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1222; equivalent gene in S.pneumoniae R6 = spr1102; identified by match to protein family HMM PF07669; type II restriction endonuclease 1112318 4441679 SPD_1080 Streptococcus pneumoniae D39 type II restriction endonuclease YP_816551.1 1110447 R 373153 CDS YP_816552.1 116516209 4441469 complement(1112393..1112647) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1223; equivalent gene in S.pneumoniae R6 = spr1103; identified by match to protein family HMM PF05016; match to protein family HMM TIGR02385; hypothetical protein 1112647 4441469 SPD_1081 Streptococcus pneumoniae D39 hypothetical protein YP_816552.1 1112393 R 373153 CDS YP_816553.1 116517043 4442357 complement(1112649..1112951) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1224; equivalent gene in S.pneumoniae R6 = spr1104; hypothetical protein 1112951 4442357 SPD_1082 Streptococcus pneumoniae D39 hypothetical protein YP_816553.1 1112649 R 373153 CDS YP_816554.1 116516804 4442200 complement(1112982..1113791) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1225; equivalent gene in S.pneumoniae R6 = spr1105; identified by match to protein family HMM PF00753; vicX protein 1113791 vicX 4442200 vicX Streptococcus pneumoniae D39 vicX protein YP_816554.1 1112982 R 373153 CDS YP_816555.1 116515922 4441065 complement(1113793..1115142) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1226; equivalent gene in S.pneumoniae R6 = spr1106; identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF00989; match to protein family HMM PF02518; match to protein family HMM TIGR00229; sensory box sensor histidine kinase 1115142 4441065 SPD_1084 Streptococcus pneumoniae D39 sensory box sensor histidine kinase YP_816555.1 1113793 R 373153 CDS YP_816556.1 116515650 4441330 complement(1115135..1115839) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1227; equivalent gene in S.pneumoniae R6 = spr1107; identified by match to protein family HMM PF00072; match to protein family HMM PF00486; DNA-binding response regulator 1115839 4441330 SPD_1085 Streptococcus pneumoniae D39 DNA-binding response regulator YP_816556.1 1115135 R 373153 CDS YP_816557.1 116516670 4442450 complement(1115894..1117069) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1228; equivalent gene in S.pneumoniae R6 = spr1108; identified by match to protein family HMM PF00633; match to protein family HMM PF00730; match to protein family HMM TIGR01084; A/G-specific adenine glycosylase 1117069 mutY 4442450 mutY Streptococcus pneumoniae D39 A/G-specific adenine glycosylase YP_816557.1 1115894 R 373153 CDS YP_816558.1 116517045 4442359 complement(1117398..1119068) 1 NC_008533.1 catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate; formate--tetrahydrofolate ligase 1119068 fhs 4442359 fhs Streptococcus pneumoniae D39 formate--tetrahydrofolate ligase YP_816558.1 1117398 R 373153 CDS YP_816559.1 116516176 4441133 1119298..1119987 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1230; equivalent gene in S.pneumoniae R6 = spr1110; identified by match to protein family HMM PF04127; match to protein family HMM TIGR02114; phosphopantothenate--cysteine ligase 1119987 coaB 4441133 coaB Streptococcus pneumoniae D39 phosphopantothenate--cysteine ligase YP_816559.1 1119298 D 373153 CDS YP_816560.1 116516321 4442804 1119999..1120550 1 NC_008533.1 decarboxylates 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine.; phosphopantothenoylcysteine decarboxylase 1120550 coaC 4442804 coaC Streptococcus pneumoniae D39 phosphopantothenoylcysteine decarboxylase YP_816560.1 1119999 D 373153 CDS YP_816561.1 116515509 4442990 1120534..1121097 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1232; equivalent gene in S.pneumoniae R6 = spr1112; hypothetical protein 1121097 4442990 SPD_1090 Streptococcus pneumoniae D39 hypothetical protein YP_816561.1 1120534 D 373153 CDS YP_816562.1 116515778 4441678 1121379..1121906 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1233; equivalent gene in S.pneumoniae R6 = spr1113; hypothetical protein 1121906 4441678 SPD_1091 Streptococcus pneumoniae D39 hypothetical protein YP_816562.1 1121379 D 373153 CDS YP_816563.1 116516020 4441582 1121918..1122433 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1114; identified by match to protein family HMM PF02829; transcriptional regulator, biotin repressor family protein 1122433 4441582 SPD_1093 Streptococcus pneumoniae D39 transcriptional regulator, biotin repressor family protein YP_816563.1 1121918 D 373153 CDS YP_816564.1 116516427 4441653 complement(1122430..1122897) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1235; equivalent gene in S.pneumoniae R6 = spr1115; identified by match to protein family HMM PF00293; MutT/nudix family protein 1122897 4441653 SPD_1092 Streptococcus pneumoniae D39 MutT/nudix family protein YP_816564.1 1122430 R 373153 CDS YP_816565.1 116516559 4441264 complement(1122971..1123459) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1236; equivalent gene in S.pneumoniae R6 = spr1116; identified by match to protein family HMM PF00583; GNAT family acetyltransferase 1123459 4441264 SPD_1094 Streptococcus pneumoniae D39 GNAT family acetyltransferase YP_816565.1 1122971 R 373153 CDS YP_816566.1 116517136 4442374 complement(1123425..1123988) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1237; equivalent gene in S.pneumoniae R6 = spr1117; hypothetical protein 1123988 4442374 SPD_1095 Streptococcus pneumoniae D39 hypothetical protein YP_816566.1 1123425 R 373153 CDS YP_816567.1 116516486 4443015 complement(1123998..1125986) 1 NC_008533.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 1125986 uvrB 4443015 uvrB Streptococcus pneumoniae D39 excinuclease ABC subunit B YP_816567.1 1123998 R 373153 CDS YP_816568.1 116515798 4441563 complement(1126063..1127016) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1240; equivalent gene in S.pneumoniae R6 = spr1119; identified by match to protein family HMM PF02517; hypothetical protein 1127016 4441563 SPD_1097 Streptococcus pneumoniae D39 hypothetical protein YP_816568.1 1126063 R 373153 CDS YP_816569.1 116516932 4442047 1127189..1129354 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1241; equivalent gene in S.pneumoniae R6 = spr1120; identified by match to protein family HMM PF00497; match to protein family HMM PF00528; match to protein family HMM TIGR01726; amino acid ABC transporter amino acid-binding protein/permease 1129354 4442047 SPD_1098 Streptococcus pneumoniae D39 amino acid ABC transporter amino acid-binding protein/permease YP_816569.1 1127189 D 373153 CDS YP_816570.1 116516532 4443083 1129354..1130094 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1242; equivalent gene in S.pneumoniae R6 = spr1121; identified by match to protein family HMM PF00005; amino acid ABC transporter ATP-binding protein 1130094 4443083 SPD_1099 Streptococcus pneumoniae D39 amino acid ABC transporter ATP-binding protein YP_816570.1 1129354 D 373153 CDS YP_816571.1 116515777 4441677 1130243..1131730 1 NC_008533.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 1131730 zwf 4441677 zwf Streptococcus pneumoniae D39 glucose-6-phosphate 1-dehydrogenase YP_816571.1 1130243 D 373153 CDS YP_816572.1 116516398 4441605 complement(1131776..1133053) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1244; equivalent gene in S.pneumoniae R6 = spr1123; identified by match to protein family HMM PF00448; match to protein family HMM PF02881; match to protein family HMM TIGR00064; signal recognition particle-docking protein FtsY 1133053 ftsY 4441605 ftsY Streptococcus pneumoniae D39 signal recognition particle-docking protein FtsY YP_816572.1 1131776 R 373153 CDS YP_816573.1 116515438 4441285 complement(1133057..1133875) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1245; equivalent gene in S.pneumoniae R6 = spr1124; identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; Cof family protein 1133875 4441285 SPD_1102 Streptococcus pneumoniae D39 Cof family protein YP_816573.1 1133057 R 373153 CDS YP_816574.1 116516975 4441995 complement(1133875..1134669) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1246; equivalent gene in S.pneumoniae R6 = spr1125; identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; Cof family protein 1134669 4441995 SPD_1103 Streptococcus pneumoniae D39 Cof family protein YP_816574.1 1133875 R 373153 CDS YP_816575.1 116515906 4442786 complement(1134666..1138205) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1247; equivalent gene in S.pneumoniae R6 = spr1126; identified by match to protein family HMM PF02463; match to protein family HMM PF06470; match to protein family HMM TIGR00650; match to protein family HMM TIGR02168; chromosome segregation protein SMC 1138205 smc 4442786 smc Streptococcus pneumoniae D39 chromosome segregation protein SMC YP_816575.1 1134666 R 373153 CDS YP_816576.1 116517072 4441922 complement(1138196..1138894) 1 NC_008533.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 1138894 rnc 4441922 rnc Streptococcus pneumoniae D39 ribonuclease III YP_816576.1 1138196 R 373153 CDS YP_816577.1 116516265 4441775 complement(1139212..1140198) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1249; equivalent gene in S.pneumoniae R6 = spr1128; identified by match to protein family HMM PF00478; match to protein family HMM TIGR01306; guanosine 5'-monophosphate oxidoreductase 1140198 guaC 4441775 guaC Streptococcus pneumoniae D39 guanosine 5'-monophosphate oxidoreductase YP_816577.1 1139212 R 373153 CDS YP_816578.1 116516577 4442098 complement(1140373..1141689) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1250; equivalent gene in S.pneumoniae R6 = spr1129; hypothetical protein 1141689 4442098 SPD_1108 Streptococcus pneumoniae D39 hypothetical protein YP_816578.1 1140373 R 373153 CDS YP_816579.1 116515594 4441214 complement(1141676..1143607) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1251; equivalent gene in S.pneumoniae R6 = spr1130; endonuclease 1143607 4441214 SPD_1109 Streptococcus pneumoniae D39 endonuclease YP_816579.1 1141676 R 373153 CDS YP_816580.1 116516694 4441368 complement(1143771..1143932) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1252; equivalent gene in S.pneumoniae R6 = spr1131; hypothetical protein 1143932 4441368 SPD_1110 Streptococcus pneumoniae D39 hypothetical protein YP_816580.1 1143771 R 373153 CDS YP_816581.1 116515996 4441500 complement(1143922..1144095) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1253; equivalent gene in S.pneumoniae R6 = spr1132; hypothetical protein 1144095 4441500 SPD_1111 Streptococcus pneumoniae D39 hypothetical protein YP_816581.1 1143922 R 373153 CDS YP_816582.1 116516497 4442618 complement(1144195..1144338) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1254; hypothetical protein 1144338 4442618 SPD_1112 Streptococcus pneumoniae D39 hypothetical protein YP_816582.1 1144195 R 373153 CDS YP_816583.1 116515583 4441202 complement(1144557..1144916) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1255; equivalent gene in S.pneumoniae R6 = spr1133; hypothetical protein 1144916 4441202 SPD_1113 Streptococcus pneumoniae D39 hypothetical protein YP_816583.1 1144557 R 373153 CDS YP_816584.1 116515939 4441341 1145014..1145127 1 NC_008533.1 hypothetical protein 1145127 4441341 SPD_1114 Streptococcus pneumoniae D39 hypothetical protein YP_816584.1 1145014 D 373153 CDS YP_816585.1 116516851 4442132 complement(1145186..1146223) 1 NC_008533.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase 1146223 leuB 4442132 leuB Streptococcus pneumoniae D39 3-isopropylmalate dehydrogenase YP_816585.1 1145186 R 373153 CDS YP_816586.1 116515984 4442435 complement(1147348..1148004) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1259; equivalent gene in S.pneumoniae R6 = spr1138; identified by match to protein family HMM PF04237; hypothetical protein 1148004 4442435 SPD_1117 Streptococcus pneumoniae D39 hypothetical protein YP_816586.1 1147348 R 373153 CDS YP_816587.1 116516861 4442143 complement(1148048..1148680) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1260; equivalent gene in S.pneumoniae R6 = spr1139; identified by match to protein family HMM PF03932; copper homeostasis protein CutC 1148680 cutC 4442143 cutC Streptococcus pneumoniae D39 copper homeostasis protein CutC YP_816587.1 1148048 R 373153 CDS YP_816588.1 116515673 4442539 complement(1148773..1149132) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1261; equivalent gene in S.pneumoniae R6 = spr1140; identified by match to protein family HMM PF04304; hypothetical protein 1149132 4442539 SPD_1119 Streptococcus pneumoniae D39 hypothetical protein YP_816588.1 1148773 R 373153 CDS YP_816589.1 116516615 4442393 complement(1149238..1151325) 1 NC_008533.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I 1151325 topA 4442393 topA Streptococcus pneumoniae D39 DNA topoisomerase I YP_816589.1 1149238 R 373153 CDS YP_816590.1 116515556 4442730 complement(1151492..1152535) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1264; equivalent gene in S.pneumoniae R6 = spr1142; identified by match to protein family HMM PF04087; hypothetical protein 1152535 4442730 SPD_1121 Streptococcus pneumoniae D39 hypothetical protein YP_816590.1 1151492 R 373153 CDS YP_816591.1 116516400 4442966 complement(1153425..1154273) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1266; equivalent gene in S.pneumoniae R6 = spr1144; identified by match to protein family HMM PF02481; match to protein family HMM TIGR00732; DNA processing protein DprA 1154273 4442966 SPD_1122 Streptococcus pneumoniae D39 DNA processing protein DprA YP_816591.1 1153425 R 373153 CDS YP_816592.1 116515684 4442550 complement(1154369..1155058) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1267; equivalent gene in S.pneumoniae R6 = spr1145; identified by match to protein family HMM PF00483; CTP:phosphocholine cytidylyltransferase 1155058 licC 4442550 licC Streptococcus pneumoniae D39 CTP:phosphocholine cytidylyltransferase YP_816592.1 1154369 R 373153 CDS YP_816593.1 116516542 4441045 complement(1155070..1155948) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1268; equivalent gene in S.pneumoniae R6 = spr1146; identified by match to protein family HMM PF00892; protein LicB 1155948 licB 4441045 licB Streptococcus pneumoniae D39 protein LicB YP_816593.1 1155070 R 373153 CDS YP_816594.1 116515546 4442720 complement(1155938..1156807) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1269; equivalent gene in S.pneumoniae R6 = spr1147; identified by match to protein family HMM PF01633; match to protein family HMM PF01636; choline kinase 1156807 pck 4442720 pck Streptococcus pneumoniae D39 choline kinase YP_816594.1 1155938 R 373153 CDS YP_816595.1 116516315 4442798 complement(1156824..1157846) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1270; equivalent gene in S.pneumoniae R6 = spr1148; zinc-containing alcohol dehydrogenase 1157846 4442798 SPD_1126 Streptococcus pneumoniae D39 zinc-containing alcohol dehydrogenase YP_816595.1 1156824 R 373153 CDS YP_816596.1 116517103 4441914 complement(1157851..1158558) 1 NC_008533.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 1158558 ispD 4441914 ispD Streptococcus pneumoniae D39 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase YP_816596.1 1157851 R 373153 CDS YP_816597.1 116516241 4441521 1158894..1160381 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1272; equivalent gene in S.pneumoniae R6 = spr1150; identified by match to protein family HMM PF01943; polysaccharide biosynthesis protein 1160381 4441521 SPD_1128 Streptococcus pneumoniae D39 polysaccharide biosynthesis protein YP_816597.1 1158894 D 373153 CDS YP_816598.1 116516858 4442139 1160391..1161194 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1273; equivalent gene in S.pneumoniae R6 = spr1151; identified by match to protein family HMM PF04991; phosphotransferase LicD1 1161194 licD1 4442139 licD1 Streptococcus pneumoniae D39 phosphotransferase LicD1 YP_816598.1 1160391 D 373153 CDS YP_816599.1 116515975 4442426 1161196..1162005 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1274; equivalent gene in S.pneumoniae R6 = spr1152; identified by match to protein family HMM PF04991; phosphotransferase LicD2 1162005 licD2 4442426 licD2 Streptococcus pneumoniae D39 phosphotransferase LicD2 YP_816599.1 1161196 D 373153 CDS YP_816600.1 116516501 4442622 complement(1162280..1165456) 1 NC_008533.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 1165456 carB 4442622 carB Streptococcus pneumoniae D39 carbamoyl phosphate synthase large subunit YP_816600.1 1162280 R 373153 CDS YP_816601.1 116515374 4441609 complement(1165769..1166848) 1 NC_008533.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 1166848 carA 4441609 carA Streptococcus pneumoniae D39 carbamoyl phosphate synthase small subunit YP_816601.1 1165769 R 373153 CDS YP_816602.1 116516819 4442176 complement(1166898..1167821) 1 NC_008533.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase catalytic subunit 1167821 pyrB 4442176 pyrB Streptococcus pneumoniae D39 aspartate carbamoyltransferase catalytic subunit YP_816602.1 1166898 R 373153 CDS YP_816603.1 116515708 4441450 complement(1167840..1168361) 1 NC_008533.1 regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity; bifunctional pyrimidine regulatory protein PyrR/uracil phosphoribosyltransferase 1168361 pyrR 4441450 pyrR Streptococcus pneumoniae D39 bifunctional pyrimidine regulatory protein PyrR/uracil phosphoribosyltransferase YP_816603.1 1167840 R 373153 CDS YP_816604.1 116516035 4441695 complement(1168572..1169201) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1279; equivalent gene in S.pneumoniae R6 = spr1157; identified by match to protein family HMM PF00633; match to protein family HMM PF00730; match to protein family HMM TIGR01083; endonuclease III 1169201 nth 4441695 nth Streptococcus pneumoniae D39 endonuclease III YP_816604.1 1168572 R 373153 CDS YP_816605.1 116516761 4442272 complement(1169201..1169743) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1280; equivalent gene in S.pneumoniae R6 = spr1158; identified by match to protein family HMM PF02620; COG1399; hypothetical protein 1169743 4442272 SPD_1136 Streptococcus pneumoniae D39 hypothetical protein YP_816605.1 1169201 R 373153 CDS YP_816606.1 116517191 4441828 1170469..1172028 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1282; equivalent gene in S.pneumoniae R6 = spr1161; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1172028 4441828 SPD_1137 Streptococcus pneumoniae D39 ABC transporter ATP-binding protein YP_816606.1 1170469 D 373153 CDS YP_816607.1 116516057 4442766 complement(1172177..1173076) 1 NC_008533.1 metalloprotease; heat shock protein HtpX 1173076 htpX 4442766 htpX Streptococcus pneumoniae D39 heat shock protein HtpX YP_816607.1 1172177 R 373153 CDS YP_816608.1 116516003 4441507 complement(1173078..1173638) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1284; equivalent gene in S.pneumoniae R6 = spr1163; identified by match to protein family HMM PF04011; LemA protein 1173638 lemA 4441507 lemA Streptococcus pneumoniae D39 LemA protein YP_816608.1 1173078 R 373153 CDS YP_816609.1 116516833 4442151 1173732..1174445 1 NC_008533.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 1174445 gidB 4442151 gidB Streptococcus pneumoniae D39 16S rRNA methyltransferase GidB YP_816609.1 1173732 D 373153 CDS YP_816610.1 116516034 4441694 1174797..1176080 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1286; equivalent gene in S.pneumoniae R6 = spr1165; identified by match to protein family HMM PF00860; match to protein family HMM TIGR00801; uracil-xanthine permease 1176080 uraA 4441694 uraA Streptococcus pneumoniae D39 uracil-xanthine permease YP_816610.1 1174797 D 373153 CDS YP_816611.1 116515651 4441332 complement(1176275..1177846) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1287; equivalent gene in S.pneumoniae R6 = spr1166; identified by match to protein family HMM PF00448; match to protein family HMM PF02881; match to protein family HMM PF02978; match to protein family HMM TIGR00959; signal recognition particle protein 1177846 ffh 4441332 ffh Streptococcus pneumoniae D39 signal recognition particle protein YP_816611.1 1176275 R 373153 CDS YP_816612.1 116515551 4442725 complement(1177858..1178190) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1288; equivalent gene in S.pneumoniae R6 = spr1167; identified by match to protein family HMM PF04297; match to protein family HMM PF04967; DNA-binding protein 1178190 4442725 SPD_1143 Streptococcus pneumoniae D39 DNA-binding protein YP_816612.1 1177858 R 373153 CDS YP_816613.1 116516359 4442961 complement(1178281..1178658) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1289; equivalent gene in S.pneumoniae R6 = spr1168; hypothetical protein 1178658 4442961 SPD_1144 Streptococcus pneumoniae D39 hypothetical protein YP_816613.1 1178281 R 373153 CDS YP_816614.1 116516095 4442689 1178730..1180034 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1290; equivalent gene in S.pneumoniae R6 = spr1169; identified by match to protein family HMM PF01966; hypothetical protein 1180034 4442689 SPD_1145 Streptococcus pneumoniae D39 hypothetical protein YP_816614.1 1178730 D 373153 CDS YP_816615.1 116516922 4442033 1180047..1180853 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1291; equivalent gene in S.pneumoniae R6 = spr1170; identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; Cof family protein 1180853 4442033 SPD_1146 Streptococcus pneumoniae D39 Cof family protein YP_816615.1 1180047 D 373153 CDS YP_816616.1 116516185 4441142 complement(1181021..1181368) 1 NC_008533.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 1181368 rplS 4441142 rplS Streptococcus pneumoniae D39 50S ribosomal protein L19 YP_816616.1 1181021 R 373153 CDS YP_816617.1 116515926 4441069 complement(1181487..1181816) 1 NC_008533.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 1181816 crcB1 4441069 crcB1 Streptococcus pneumoniae D39 camphor resistance protein CrcB YP_816617.1 1181487 R 373153 CDS YP_816618.1 116516795 4442190 complement(1181810..1182184) 1 NC_008533.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 1182184 crcB2 4442190 crcB2 Streptococcus pneumoniae D39 camphor resistance protein CrcB YP_816618.1 1181810 R 373153 CDS YP_816619.1 116516649 4443053 complement(1182181..1182447) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1296; equivalent gene in S.pneumoniae R6 = spr1174; identified by match to protein family HMM PF01817; match to protein family HMM TIGR01805; hypothetical protein 1182447 4443053 SPD_1151 Streptococcus pneumoniae D39 hypothetical protein YP_816619.1 1182181 R 373153 CDS YP_816620.1 116516999 4441982 complement(1182563..1183006) 1 NC_008533.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin 1183006 fld 4441982 fld Streptococcus pneumoniae D39 flavodoxin YP_816620.1 1182563 R 373153 CDS YP_816621.1 116516410 4442976 1183110..1184045 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1298; equivalent gene in S.pneumoniae R6 = spr1176; identified by match to protein family HMM PF01368; match to protein family HMM PF02272; DHH subfamily 1 protein 1184045 4442976 SPD_1153 Streptococcus pneumoniae D39 DHH subfamily 1 protein YP_816621.1 1183110 D 373153 CDS YP_816622.1 116515764 4442420 1184141..1184383 1 NC_008533.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 1184383 rpmE2 4442420 rpmE2 Streptococcus pneumoniae D39 50S ribosomal protein L31 YP_816622.1 1184141 D 373153 CDS YP_816623.1 116516672 4442452 complement(1184440..1185018) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1300; equivalent gene in S.pneumoniae R6 = spr1178; hypothetical protein 1185018 4442452 SPD_1155 Streptococcus pneumoniae D39 hypothetical protein YP_816623.1 1184440 R 373153 CDS YP_816624.1 116516026 4441686 complement(1184993..1185997) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1179; identified by match to protein family HMM PF04261; match to protein family HMM TIGR01413; Dyp-type peroxidase family protein 1185997 4441686 SPD_1156 Streptococcus pneumoniae D39 Dyp-type peroxidase family protein YP_816624.1 1184993 R 373153 CDS YP_816625.1 116516847 4442167 complement(1186049..1186315) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0733; equivalent gene in S.pneumoniae R6 = spr1180; hypothetical protein 1186315 4442167 SPD_1157 Streptococcus pneumoniae D39 hypothetical protein YP_816625.1 1186049 R 373153 CDS YP_816626.1 116516965 4442918 1187003..1188349 1 NC_008533.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; glutamate dehydrogenase 1188349 gdhA 4442918 gdhA Streptococcus pneumoniae D39 glutamate dehydrogenase YP_816626.1 1187003 D 373153 CDS YP_816627.1 116515897 4442776 complement(1188845..1189015) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1307; equivalent gene in S.pneumoniae R6 = spr1182; hypothetical protein 1189015 4442776 SPD_1159 Streptococcus pneumoniae D39 hypothetical protein YP_816627.1 1188845 R 373153 CDS YP_816628.1 116516496 4442617 complement(1189028..1189669) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1308; equivalent gene in S.pneumoniae R6 = spr1183; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1189669 4442617 SPD_1160 Streptococcus pneumoniae D39 ABC transporter ATP-binding protein YP_816628.1 1189028 R 373153 CDS YP_816629.1 116516155 4442517 1189941..1190378 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1184; hypothetical protein 1190378 4442517 SPD_1161 Streptococcus pneumoniae D39 hypothetical protein YP_816629.1 1189941 D 373153 CDS YP_816630.1 116516734 4442323 complement(1190669..1190872) 1 NC_008533.1 This gene is a fragement of the glucokinase genes 3' end. equivalent gene in S.pneumoniae R6 = spr1185; hypothetical protein 1190872 4442323 SPD_1162 Streptococcus pneumoniae D39 hypothetical protein YP_816630.1 1190669 R 373153 CDS YP_816631.1 116515419 4442489 complement(1190890..1191621) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1676; equivalent gene in S.pneumoniae R6 = spr1186; identified by match to protein family HMM PF00701; N-acetylneuraminate lyase 1191621 4442489 SPD_1163 Streptococcus pneumoniae D39 N-acetylneuraminate lyase YP_816631.1 1190890 R 373153 CDS YP_816632.1 116516518 4443069 complement(1191839..1192246) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1188; identified by match to protein family HMM PF00383; match to protein family HMM TIGR01354; cytidine deaminase 1192246 cdd-2 4443069 cdd-2 Streptococcus pneumoniae D39 cytidine deaminase YP_816632.1 1191839 R 373153 CDS YP_816633.1 116515484 4442654 complement(1192534..1193022) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1189; hypothetical protein 1193022 4442654 SPD_1165 Streptococcus pneumoniae D39 hypothetical protein YP_816633.1 1192534 R 373153 CDS YP_816634.1 116515829 4441120 complement(1193027..1194436) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1190; hypothetical protein 1194436 4441120 SPD_1166 Streptococcus pneumoniae D39 hypothetical protein YP_816634.1 1193027 R 373153 CDS YP_816635.1 116515706 4441448 complement(1194446..1196428) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1191; identified by match to protein family HMM PF00005; match to protein family HMM TIGR01727; ABC transporter ATP-binding protein 1196428 4441448 SPD_1167 Streptococcus pneumoniae D39 ABC transporter ATP-binding protein YP_816635.1 1194446 R 373153 CDS YP_816636.1 116515771 4441671 complement(1196441..1197292) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1192; identified by match to protein family HMM PF00528; oligopeptide ABC transporter pemease protein 1197292 4441671 SPD_1168 Streptococcus pneumoniae D39 oligopeptide ABC transporter pemease protein YP_816636.1 1196441 R 373153 CDS YP_816637.1 116516656 4443060 complement(1197309..1198259) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1193; identified by match to protein family HMM PF00528; oligopeptide ABC transporter permease 1198259 4443060 SPD_1169 Streptococcus pneumoniae D39 oligopeptide ABC transporter permease YP_816637.1 1197309 R 373153 CDS YP_816638.1 116515339 4441081 complement(1198369..1199997) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1194; identified by match to protein family HMM PF00496; oligopeptide ABC transporteroligopeptide-binding protein 1199997 4441081 SPD_1170 Streptococcus pneumoniae D39 oligopeptide ABC transporteroligopeptide-binding protein YP_816638.1 1198369 R 373153 CDS YP_816639.1 116516633 4441422 complement(1200079..1201002) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1195; identified by match to protein family HMM PF07646; hypothetical protein 1201002 4441422 SPD_1171 Streptococcus pneumoniae D39 hypothetical protein YP_816639.1 1200079 R 373153 CDS YP_816640.1 116516481 4443010 complement(1201026..1201724) 1 NC_008533.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase 1201724 nanE-2 4443010 nanE-2 Streptococcus pneumoniae D39 N-acetylmannosamine-6-phosphate 2-epimerase YP_816640.1 1201026 R 373153 CDS YP_816641.1 116517215 4441813 complement(1202617..1202838) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1199; hypothetical protein 1202838 4441813 SPD_1174 Streptococcus pneumoniae D39 hypothetical protein YP_816641.1 1202617 R 373153 CDS YP_816642.1 116515372 4441607 complement(1203902..1205221) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1340; equivalent gene in S.pneumoniae R6 = spr1201; hypothetical protein 1205221 4441607 SPD_1175 Streptococcus pneumoniae D39 hypothetical protein YP_816642.1 1203902 R 373153 CDS YP_816643.1 116516042 4441702 complement(1205224..1205964) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1341; equivalent gene in S.pneumoniae R6 = spr1202; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1205964 4441702 SPD_1176 Streptococcus pneumoniae D39 ABC transporter ATP-binding protein YP_816643.1 1205224 R 373153 CDS YP_816644.1 116517121 4441893 complement(1205979..1207586) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1342; equivalent gene in S.pneumoniae R6 = spr1203; identified by match to protein family HMM PF00005; match to protein family HMM PF00664; drug efflux ABC transporter ATP-binding protein/permease 1207586 4441893 SPD_1177 Streptococcus pneumoniae D39 drug efflux ABC transporter ATP-binding protein/permease YP_816644.1 1205979 R 373153 CDS YP_816645.1 116516607 4442384 complement(1207583..1209523) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1343; equivalent gene in S.pneumoniae R6 = spr1204; identified by match to protein family HMM PF00326; prolyl oligopeptidase family protein 1209523 4442384 SPD_1178 Streptococcus pneumoniae D39 prolyl oligopeptidase family protein YP_816645.1 1207583 R 373153 CDS YP_816646.1 116515683 4442549 complement(1209556..1212165) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1344; equivalent gene in S.pneumoniae R6 = spr1205; identified by match to protein family HMM PF05147; hypothetical protein 1212165 4442549 SPD_1179 Streptococcus pneumoniae D39 hypothetical protein YP_816646.1 1209556 R 373153 CDS YP_816647.1 116515695 4441436 complement(1212683..1213270) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1346; equivalent gene in S.pneumoniae R6 = spr1206; identified by match to protein family HMM PF02517; CAAX amino terminal protease family protein 1213270 4441436 SPD_1180 Streptococcus pneumoniae D39 CAAX amino terminal protease family protein YP_816647.1 1212683 R 373153 CDS YP_816648.1 116516016 4441578 complement(1213363..1213506) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1333; hypothetical protein 1213506 4441578 SPD_1181 Streptococcus pneumoniae D39 hypothetical protein YP_816648.1 1213363 R 373153 CDS YP_816649.1 116516880 4442123 complement(1213519..1213899) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1348; equivalent gene in S.pneumoniae R6 = spr1207; hypothetical protein 1213899 4442123 SPD_1182 Streptococcus pneumoniae D39 hypothetical protein YP_816649.1 1213519 R 373153 CDS YP_816650.1 116516289 4442578 complement(1213954..1214232) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1349; equivalent gene in S.pneumoniae R6 = spr1208; hypothetical protein 1214232 4442578 SPD_1183 Streptococcus pneumoniae D39 hypothetical protein YP_816650.1 1213954 R 373153 CDS YP_816651.1 116515907 4442787 complement(1214240..1214494) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1350; equivalent gene in S.pneumoniae R6 = spr1209; identified by match to protein family HMM PF06970; hypothetical protein 1214494 4442787 SPD_1184 Streptococcus pneumoniae D39 hypothetical protein YP_816651.1 1214240 R 373153 CDS YP_816652.1 116516935 4442050 complement(1214491..1214664) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1210; hypothetical protein 1214664 4442050 SPD_1185 Streptococcus pneumoniae D39 hypothetical protein YP_816652.1 1214491 R 373153 CDS YP_816653.1 116515620 4442700 1214640..1214822 1 NC_008533.1 hypothetical protein 1214822 4442700 SPD_1186 Streptococcus pneumoniae D39 hypothetical protein YP_816653.1 1214640 D 373153 CDS YP_816654.1 116516621 4442399 complement(1214852..1215220) 1 NC_008533.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 1215220 rplL 4442399 rplL Streptococcus pneumoniae D39 50S ribosomal protein L7/L12 YP_816654.1 1214852 R 373153 CDS YP_816655.1 116516650 4443054 complement(1215296..1215796) 1 NC_008533.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 1215796 rplJ 4443054 rplJ Streptococcus pneumoniae D39 50S ribosomal protein L10 YP_816655.1 1215296 R 373153 CDS YP_816656.1 116516775 4442228 1215801..1216025 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1213; hypothetical protein 1216025 4442228 SPD_1189 Streptococcus pneumoniae D39 hypothetical protein YP_816656.1 1215801 D 373153 CDS YP_816657.1 116515507 4442988 complement(1216046..1217305) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1356; equivalent gene in S.pneumoniae R6 = spr1214; identified by match to protein family HMM PF01979; match to protein family HMM PF07969; chlorohydrolase 1217305 4442988 SPD_1190 Streptococcus pneumoniae D39 chlorohydrolase YP_816657.1 1216046 R 373153 CDS YP_816658.1 116516549 4441053 complement(1217607..1219358) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1357; equivalent gene in S.pneumoniae R6 = spr1215; identified by match to protein family HMM PF00005; match to protein family HMM PF00664; ABC transporter ATP-binding protein/permease 1219358 4441053 SPD_1191 Streptococcus pneumoniae D39 ABC transporter ATP-binding protein/permease YP_816658.1 1217607 R 373153 CDS YP_816659.1 116516223 4441483 complement(1219360..1221084) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1358; equivalent gene in S.pneumoniae R6 = spr1216; identified by match to protein family HMM PF00005; match to protein family HMM PF00664; ABC transporter ATP-binding protein/permease 1221084 4441483 SPD_1192 Streptococcus pneumoniae D39 ABC transporter ATP-binding protein/permease YP_816659.1 1219360 R 373153 CDS YP_816660.1 116516363 4442965 complement(1221142..1222080) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1359; equivalent gene in S.pneumoniae R6 = spr1217; identified by match to protein family HMM PF01625; match to protein family HMM PF01641; match to protein family HMM TIGR00357; match to protein family HMM TIGR00401; bifunctional methionine sulfoxide reductase A/B 1222080 msrAB1 4442965 msrAB1 Streptococcus pneumoniae D39 bifunctional methionine sulfoxide reductase A/B YP_816660.1 1221142 R 373153 CDS YP_816661.1 116517101 4441912 complement(1222376..1223245) 1 NC_008533.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase 1223245 thrB 4441912 thrB Streptococcus pneumoniae D39 homoserine kinase YP_816661.1 1222376 R 373153 CDS YP_816662.1 116516244 4441524 complement(1223247..1224533) 1 NC_008533.1 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine; homoserine dehydrogenase 1224533 hom 4441524 hom Streptococcus pneumoniae D39 homoserine dehydrogenase YP_816662.1 1223247 R 373153 CDS YP_816663.1 116515689 4442555 complement(1224684..1225421) 1 NC_008533.1 enables recognition and targeting of proteins for proteolysis, involved in negative regulation of competence; adaptor protein 1225421 mecA 4442555 mecA Streptococcus pneumoniae D39 adaptor protein YP_816663.1 1224684 R 373153 CDS YP_816664.1 116516014 4441576 complement(1225563..1226597) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1363; equivalent gene in S.pneumoniae R6 = spr1221; hypothetical protein 1226597 4441576 SPD_1197 Streptococcus pneumoniae D39 hypothetical protein YP_816664.1 1225563 R 373153 CDS YP_816665.1 116515719 4442257 complement(1226626..1228059) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1364; equivalent gene in S.pneumoniae R6 = spr1222; hypothetical protein 1228059 4442257 SPD_1198 Streptococcus pneumoniae D39 hypothetical protein YP_816665.1 1226626 R 373153 CDS YP_816666.1 116516760 4442271 complement(1228075..1229061) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1365; equivalent gene in S.pneumoniae R6 = spr1223; identified by match to protein family HMM PF00535; glycosyl transferase family protein 1229061 4442271 SPD_1199 Streptococcus pneumoniae D39 glycosyl transferase family protein YP_816666.1 1228075 R 373153 CDS YP_816667.1 116516575 4442096 complement(1229063..1230163) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1366; equivalent gene in S.pneumoniae R6 = spr1224; identified by match to protein family HMM PF00534; glycoside hydrolase family protein 1230163 4442096 SPD_1200 Streptococcus pneumoniae D39 glycoside hydrolase family protein YP_816667.1 1229063 R 373153 CDS YP_816668.1 116515753 4442408 complement(1230156..1231001) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1367; equivalent gene in S.pneumoniae R6 = spr1225; identified by match to protein family HMM PF04991; phosphotransferase LicD3 1231001 licD3 4442408 licD3 Streptococcus pneumoniae D39 phosphotransferase LicD3 YP_816668.1 1230156 R 373153 CDS YP_816669.1 116516217 4441477 complement(1231280..1232554) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1368; equivalent gene in S.pneumoniae R6 = spr1226; identified by match to protein family HMM PF03816; match to protein family HMM TIGR00350; Psr protein 1232554 psr 4441477 psr Streptococcus pneumoniae D39 Psr protein YP_816669.1 1231280 R 373153 CDS YP_816670.1 116515473 4442643 complement(1232551..1233399) 1 NC_008533.1 catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; prephenate dehydratase 1233399 4442643 SPD_1203 Streptococcus pneumoniae D39 prephenate dehydratase YP_816670.1 1232551 R 373153 CDS YP_816671.1 116517070 4441920 complement(1233396..1233872) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1370; equivalent gene in S.pneumoniae R6 = spr1228; identified by match to protein family HMM PF01202; shikimate kinase 1233872 aroK 4441920 aroK Streptococcus pneumoniae D39 shikimate kinase YP_816671.1 1233396 R 373153 CDS YP_816672.1 116515889 4441387 complement(1233865..1235148) 1 NC_008533.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase 1235148 aroA 4441387 aroA Streptococcus pneumoniae D39 3-phosphoshikimate 1-carboxyvinyltransferase YP_816672.1 1233865 R 373153 CDS YP_816673.1 116515360 4441160 complement(1235240..1235578) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1372; equivalent gene in S.pneumoniae R6 = spr1230; identified by match to protein family HMM PF06133; hypothetical protein 1235578 4441160 SPD_1206 Streptococcus pneumoniae D39 hypothetical protein YP_816673.1 1235240 R 373153 CDS YP_816674.1 116516215 4441475 complement(1235589..1236692) 1 NC_008533.1 catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate; prephenate dehydrogenase 1236692 tyrA 4441475 tyrA Streptococcus pneumoniae D39 prephenate dehydrogenase YP_816674.1 1235589 R 373153 CDS YP_816675.1 116516017 4441579 complement(1236702..1237868) 1 NC_008533.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase 1237868 aroC 4441579 aroC Streptococcus pneumoniae D39 chorismate synthase YP_816675.1 1236702 R 373153 CDS YP_816676.1 116516860 4442142 complement(1237878..1238945) 1 NC_008533.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 1238945 aroB 4442142 aroB Streptococcus pneumoniae D39 3-dehydroquinate synthase YP_816676.1 1237878 R 373153 CDS YP_816677.1 116516036 4441696 complement(1238964..1239818) 1 NC_008533.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase 1239818 aroE 4441696 aroE Streptococcus pneumoniae D39 shikimate 5-dehydrogenase YP_816677.1 1238964 R 373153 CDS YP_816678.1 116517065 4441953 complement(1239808..1240485) 1 NC_008533.1 catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis; 3-dehydroquinate dehydratase 1240485 aroD 4441953 aroD Streptococcus pneumoniae D39 3-dehydroquinate dehydratase YP_816678.1 1239808 R 373153 CDS YP_816679.1 116516182 4441139 complement(1240482..1241654) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1378; equivalent gene in S.pneumoniae R6 = spr1236; hypothetical protein 1241654 4441139 SPD_1212 Streptococcus pneumoniae D39 hypothetical protein YP_816679.1 1240482 R 373153 CDS YP_816680.1 116516512 4442633 complement(1242332..1243966) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1380; equivalent gene in S.pneumoniae R6 = spr1237; hypothetical protein 1243966 4442633 SPD_1213 Streptococcus pneumoniae D39 hypothetical protein YP_816680.1 1242332 R 373153 CDS YP_816681.1 116515435 4441282 complement(1243947..1244696) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1381; equivalent gene in S.pneumoniae R6 = spr1238; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1244696 4441282 SPD_1214 Streptococcus pneumoniae D39 ABC transporter ATP-binding protein YP_816681.1 1243947 R 373153 CDS YP_816682.1 116516517 4443068 1244874..1246328 1 NC_008533.1 converts 1,4-alpha-D-glucans to maltodextrin; alpha-amylase 1246328 amy 4443068 amy Streptococcus pneumoniae D39 alpha-amylase YP_816682.1 1244874 D 373153 CDS YP_816683.1 116515613 4442752 complement(1246418..1249036) 1 NC_008533.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 1249036 alaS 4442752 alaS Streptococcus pneumoniae D39 alanyl-tRNA synthetase YP_816683.1 1246418 R 373153 CDS YP_816684.1 116515414 4442484 complement(1249058..1249543) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1384; equivalent gene in S.pneumoniae R6 = spr1241; identified by match to protein family HMM PF04525; hypothetical protein 1249543 4442484 SPD_1217 Streptococcus pneumoniae D39 hypothetical protein YP_816684.1 1249058 R 373153 CDS YP_816685.1 116516276 4442604 complement(1250318..1251388) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1386; equivalent gene in S.pneumoniae R6 = spr1243; identified by match to protein family HMM PF01547; spermidine/putrescine ABC transporter spermidine/putrescine-binding protein 1251388 potD 4442604 potD Streptococcus pneumoniae D39 spermidine/putrescine ABC transporter spermidine/putrescine-binding protein YP_816685.1 1250318 R 373153 CDS YP_816686.1 116517092 4441903 complement(1251385..1252158) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1387; equivalent gene in S.pneumoniae R6 = spr1244; identified by match to protein family HMM PF00528; spermidine/putrescine ABC transporter permease 1252158 potC 4441903 potC Streptococcus pneumoniae D39 spermidine/putrescine ABC transporter permease YP_816686.1 1251385 R 373153 CDS YP_816687.1 116515539 4442904 complement(1252155..1252961) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1388; equivalent gene in S.pneumoniae R6 = spr1245; identified by match to protein family HMM PF00528; spermidine/putrescine ABC transporter permease 1252961 potH 4442904 potH Streptococcus pneumoniae D39 spermidine/putrescine ABC transporter permease YP_816687.1 1252155 R 373153 CDS YP_816688.1 116516399 4441606 complement(1252942..1254099) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1389; equivalent gene in S.pneumoniae R6 = spr1246; identified by match to protein family HMM PF00005; spermidine/putrescine ABC transporter ATP-binding protein 1254099 potA 4441606 potA Streptococcus pneumoniae D39 spermidine/putrescine ABC transporter ATP-binding protein YP_816688.1 1252942 R 373153 CDS YP_816689.1 116515736 4441024 complement(1254158..1255108) 1 NC_008533.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 1255108 murB 4441024 murB Streptococcus pneumoniae D39 UDP-N-acetylenolpyruvoylglucosamine reductase YP_816689.1 1254158 R 373153 CDS YP_816690.1 116516196 4441455 complement(1255220..1255972) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1391; equivalent gene in S.pneumoniae R6 = spr1248; hypothetical protein 1255972 4441455 SPD_1223 Streptococcus pneumoniae D39 hypothetical protein YP_816690.1 1255220 R 373153 CDS YP_816691.1 116516826 4442183 complement(1255982..1256713) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1392; equivalent gene in S.pneumoniae R6 = spr1249; identified by match to protein family HMM PF03306; match to protein family HMM TIGR01252; alpha-acetolactate decarboxylase 1256713 budA 4442183 budA Streptococcus pneumoniae D39 alpha-acetolactate decarboxylase YP_816691.1 1255982 R 373153 CDS YP_816692.1 116515504 4441314 1256855..1258126 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1393; equivalent gene in S.pneumoniae R6 = spr1250; identified by match to protein family HMM PF00392; hypothetical protein 1258126 4441314 SPD_1225 Streptococcus pneumoniae D39 hypothetical protein YP_816692.1 1256855 D 373153 CDS YP_816693.1 116516603 4441233 complement(1258146..1258961) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1394; equivalent gene in S.pneumoniae R6 = spr1251; identified by match to protein family HMM PF00497; amino acid ABC transporter amino acid-binding protein 1258961 4441233 SPD_1226 Streptococcus pneumoniae D39 amino acid ABC transporter amino acid-binding protein YP_816693.1 1258146 R 373153 CDS YP_816694.1 116515809 4442856 complement(1259118..1259771) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1395; equivalent gene in S.pneumoniae R6 = spr1252; identified by match to protein family HMM PF01895; match to protein family HMM TIGR02135; phosphate transport system regulatory protein PhoU 1259771 4442856 SPD_1227 Streptococcus pneumoniae D39 phosphate transport system regulatory protein PhoU YP_816694.1 1259118 R 373153 CDS YP_816695.1 116516421 4441647 complement(1259783..1260541) 1 NC_008533.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein 1260541 4441647 SPD_1228 Streptococcus pneumoniae D39 phosphate transporter ATP-binding protein YP_816695.1 1259783 R 373153 CDS YP_816696.1 116516038 4441698 complement(1260554..1261357) 1 NC_008533.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein 1261357 4441698 SPD_1229 Streptococcus pneumoniae D39 phosphate transporter ATP-binding protein YP_816696.1 1260554 R 373153 CDS YP_816697.1 116516821 4442178 complement(1261368..1262252) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1398; equivalent gene in S.pneumoniae R6 = spr1255; identified by match to protein family HMM PF00528; match to protein family HMM TIGR00974; phosphate ABC transporter permease 1262252 4442178 SPD_1230 Streptococcus pneumoniae D39 phosphate ABC transporter permease YP_816697.1 1261368 R 373153 CDS YP_816698.1 116516273 4442601 complement(1262242..1263159) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1399; equivalent gene in S.pneumoniae R6 = spr1256; identified by match to protein family HMM PF00528; match to protein family HMM TIGR02138; phosphate ABC transporter permease 1263159 4442601 SPD_1231 Streptococcus pneumoniae D39 phosphate ABC transporter permease YP_816698.1 1262242 R 373153 CDS YP_816699.1 116517085 4441935 complement(1263159..1264037) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1400; equivalent gene in S.pneumoniae R6 = spr1257; identified by match to protein family HMM PF01547; match to protein family HMM TIGR02136; phosphate ABC transporter substrate-binding protein 1264037 4441935 SPD_1232 Streptococcus pneumoniae D39 phosphate ABC transporter substrate-binding protein YP_816699.1 1263159 R 373153 CDS YP_816700.1 116516379 4443042 complement(1264611..1265915) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1402; equivalent gene in S.pneumoniae R6 = spr1259; identified by match to protein family HMM PF01189; NOL1/NOP2/sun family protein 1265915 4443042 SPD_1233 Streptococcus pneumoniae D39 NOL1/NOP2/sun family protein YP_816700.1 1264611 R 373153 CDS YP_816701.1 116515379 4441615 complement(1265916..1266689) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1403; equivalent gene in S.pneumoniae R6 = spr1260; identified by match to protein family HMM PF00459; inositol monophosphatase family protein 1266689 4441615 SPD_1234 Streptococcus pneumoniae D39 inositol monophosphatase family protein YP_816701.1 1265916 R 373153 CDS YP_816702.1 116516476 4442946 complement(1266679..1266957) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1404; equivalent gene in S.pneumoniae R6 = spr1261; identified by match to protein family HMM PF05256; hypothetical protein 1266957 4442946 SPD_1235 Streptococcus pneumoniae D39 hypothetical protein YP_816702.1 1266679 R 373153 CDS YP_816703.1 116515656 4441239 complement(1266957..1267358) 1 NC_008533.1 the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress; transcriptional regulator Spx 1267358 spxA 4441239 spxA Streptococcus pneumoniae D39 transcriptional regulator Spx YP_816703.1 1266957 R 373153 CDS YP_816704.1 116515535 4442900 complement(1267568..1268185) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1406; equivalent gene in S.pneumoniae R6 = spr1263; identified by match to protein family HMM PF07314; match to protein family HMM TIGR01906; hypothetical protein 1268185 4442900 SPD_1237 Streptococcus pneumoniae D39 hypothetical protein YP_816704.1 1267568 R 373153 CDS YP_816705.1 116516703 4442329 complement(1268175..1268948) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1407; equivalent gene in S.pneumoniae R6 = spr1264; identified by match to protein family HMM PF00702; match to protein family HMM TIGR01457; match to protein family HMM TIGR01460; hydrolase 1268948 4442329 SPD_1238 Streptococcus pneumoniae D39 hydrolase YP_816705.1 1268175 R 373153 CDS YP_816706.1 116516253 4441763 complement(1268959..1269696) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1408; equivalent gene in S.pneumoniae R6 = spr1265; identified by match to protein family HMM PF01643; acyl-ACP thioesterase 1269696 4441763 SPD_1239 Streptococcus pneumoniae D39 acyl-ACP thioesterase YP_816706.1 1268959 R 373153 CDS YP_816707.1 116517056 4441944 complement(1269701..1270831) 1 NC_008533.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 1270831 4441944 SPD_1240 Streptococcus pneumoniae D39 coproporphyrinogen III oxidase YP_816707.1 1269701 R 373153 CDS YP_816708.1 116516688 4441362 complement(1270915..1271304) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1410; equivalent gene in S.pneumoniae R6 = spr1267; hypothetical protein 1271304 4441362 SPD_1241 Streptococcus pneumoniae D39 hypothetical protein YP_816708.1 1270915 R 373153 CDS YP_816709.1 116515390 4442460 complement(1271320..1271703) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1411; equivalent gene in S.pneumoniae R6 = spr1268; identified by match to protein family HMM PF06103; hypothetical protein 1271703 4442460 SPD_1242 Streptococcus pneumoniae D39 hypothetical protein YP_816709.1 1271320 R 373153 CDS YP_816710.1 116515924 4441067 complement(1271704..1272492) 1 NC_008533.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase 1272492 lgt 4441067 lgt Streptococcus pneumoniae D39 prolipoprotein diacylglyceryl transferase YP_816710.1 1271704 R 373153 CDS YP_816711.1 116515609 4442748 complement(1272485..1273420) 1 NC_008533.1 catalyzes the phosphorylation of the phosphocarrier protein HPr of the bacterial phosphotransferase system; HPr kinase/phosphorylase 1273420 hprK 4442748 hprK Streptococcus pneumoniae D39 HPr kinase/phosphorylase YP_816711.1 1272485 R 373153 CDS YP_816712.1 116517095 4441906 complement(1273550..1273726) 1 NC_008533.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 1273726 rpsU 4441906 rpsU Streptococcus pneumoniae D39 30S ribosomal protein S21 YP_816712.1 1273550 R 373153 CDS YP_816713.1 116516222 4441482 complement(1273866..1274573) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1415; equivalent gene in S.pneumoniae R6 = spr1272; identified by match to protein family HMM PF01182; glucosamine-6-phosphate isomerase 1274573 nagB 4441482 nagB Streptococcus pneumoniae D39 glucosamine-6-phosphate isomerase YP_816713.1 1273866 R 373153 CDS YP_816714.1 116515685 4442551 1274724..1275752 1 NC_008533.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine--tRNA ribosyltransferase-isomerase 1275752 queA 4442551 queA Streptococcus pneumoniae D39 S-adenosylmethionine--tRNA ribosyltransferase-isomerase YP_816714.1 1274724 D 373153 CDS YP_816715.1 116517173 4441849 complement(1276301..1276690) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1274 The R6 gene is annotated as a choline binding protein truncation (spsA-truncation); identified by match to protein family HMM PF01473; hypothetical protein 1276690 4441849 SPD_1248 Streptococcus pneumoniae D39 hypothetical protein YP_816715.1 1276301 R 373153 CDS YP_816716.1 116516411 4442977 complement(1278144..1278695) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1419; equivalent gene in S.pneumoniae R6 = spr1275; identified by match to protein family HMM PF00583; acetyltransferase 1278695 4442977 SPD_1249 Streptococcus pneumoniae D39 acetyltransferase YP_816716.1 1278144 R 373153 CDS YP_816717.1 116515793 4441558 complement(1278942..1279766) 1 NC_008533.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase 1279766 nadE 4441558 nadE Streptococcus pneumoniae D39 NAD synthetase YP_816717.1 1278942 R 373153 CDS YP_816718.1 116515881 4441378 complement(1279763..1281223) 1 NC_008533.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase 1281223 pncB 4441378 pncB Streptococcus pneumoniae D39 nicotinate phosphoribosyltransferase YP_816718.1 1279763 R 373153 CDS YP_816719.1 116516827 4442184 complement(1281339..1281827) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1422; equivalent gene in S.pneumoniae R6 = spr1278; hypothetical protein 1281827 4442184 SPD_1252 Streptococcus pneumoniae D39 hypothetical protein YP_816719.1 1281339 R 373153 CDS YP_816720.1 116517019 4441964 complement(1281817..1282026) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1423; equivalent gene in S.pneumoniae R6 = spr1279; identified by match to protein family HMM PF01381; transcriptional repressor 1282026 4441964 SPD_1253 Streptococcus pneumoniae D39 transcriptional repressor YP_816720.1 1281817 R 373153 CDS YP_816721.1 116515882 4441379 complement(1282411..1283139) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1424; equivalent gene in S.pneumoniae R6 = spr1280; hypothetical protein 1283139 4441379 SPD_1254 Streptococcus pneumoniae D39 hypothetical protein YP_816721.1 1282411 R 373153 CDS YP_816722.1 116516301 4442590 complement(1283155..1283877) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1426; equivalent gene in S.pneumoniae R6 = spr1281; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1283877 4442590 SPD_1255 Streptococcus pneumoniae D39 ABC transporter ATP-binding protein YP_816722.1 1283155 R 373153 CDS YP_816723.1 116515450 4441174 complement(1284382..1285107) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1427; equivalent gene in S.pneumoniae R6 = spr1282; identified by match to protein family HMM PF01136; peptidase, U32 family protein 1285107 4441174 SPD_1256 Streptococcus pneumoniae D39 peptidase, U32 family protein YP_816723.1 1284382 R 373153 CDS YP_816724.1 116516820 4442177 1285274..1285441 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1283; hypothetical protein 1285441 4442177 SPD_1257 Streptococcus pneumoniae D39 hypothetical protein YP_816724.1 1285274 D 373153 CDS YP_816725.1 116516724 4442312 complement(1285696..1286982) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1429; equivalent gene in S.pneumoniae R6 = spr1284; identified by match to protein family HMM PF01136; peptidase, U32 family protein 1286982 4442312 SPD_1258 Streptococcus pneumoniae D39 peptidase, U32 family protein YP_816725.1 1285696 R 373153 CDS YP_816726.1 116516980 4442000 1288160..1289338 1 NC_008533.1 Possibly an isoschizomer of XbaI. equivalent gene in S.pneumoniae TIGR4 = SP1431; equivalent gene in S.pneumoniae R6 spr1287; identified by match to protein family HMM PF01555; type II DNA modification methyltransferase 1289338 4442000 SPD_1260 Streptococcus pneumoniae D39 type II DNA modification methyltransferase YP_816726.1 1288160 D 373153 CDS YP_816727.1 116516629 4441417 1289597..1289743 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1432; hypothetical protein 1289743 4441417 SPD_1261 Streptococcus pneumoniae D39 hypothetical protein YP_816727.1 1289597 D 373153 CDS YP_816728.1 116515319 4442662 complement(1289865..1290857) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1433; equivalent gene in S.pneumoniae R6 = spr1288; identified by match to protein family HMM PF00165; AraC family transcriptional regulator 1290857 4442662 SPD_1262 Streptococcus pneumoniae D39 AraC family transcriptional regulator YP_816728.1 1289865 R 373153 CDS YP_816729.1 116516409 4442975 1291017..1292771 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1434; equivalent gene in S.pneumoniae R6 = spr1289; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein/permease 1292771 4442975 SPD_1263 Streptococcus pneumoniae D39 ABC transporter ATP-binding protein/permease YP_816729.1 1291017 D 373153 CDS YP_816730.1 116515983 4442434 1292755..1294476 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1435; equivalent gene in S.pneumoniae R6 = spr1290; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1294476 4442434 SPD_1264 Streptococcus pneumoniae D39 ABC transporter ATP-binding protein YP_816730.1 1292755 D 373153 CDS YP_816731.1 116517054 4441942 1294487..1295071 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1436; equivalent gene in S.pneumoniae R6 = spr1291; identified by match to protein family HMM TIGR02185; hypothetical protein 1295071 4441942 SPD_1265 Streptococcus pneumoniae D39 hypothetical protein YP_816731.1 1294487 D 373153 CDS YP_816732.1 116516131 4442219 1295071..1295766 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1437; equivalent gene in S.pneumoniae R6 = spr1292; identified by match to protein family HMM PF02361; hypothetical protein 1295766 4442219 SPD_1266 Streptococcus pneumoniae D39 hypothetical protein YP_816732.1 1295071 D 373153 CDS YP_816733.1 116516582 4442105 1295754..1297118 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1438; equivalent gene in S.pneumoniae R6 = spr1293; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1297118 4442105 SPD_1267 Streptococcus pneumoniae D39 ABC transporter ATP-binding protein YP_816733.1 1295754 D 373153 CDS YP_816734.1 116515677 4442543 complement(1297906..1298367) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1294; hypothetical protein 1298367 4442543 SPD_1268 Streptococcus pneumoniae D39 hypothetical protein YP_816734.1 1297906 R 373153 CDS YP_816735.1 116516700 4442326 complement(1298440..1298652) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1295; hypothetical protein 1298652 4442326 SPD_1269 Streptococcus pneumoniae D39 hypothetical protein YP_816735.1 1298440 R 373153 CDS YP_816736.1 116515801 4441566 complement(1298661..1298966) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1296; hypothetical protein 1298966 4441566 SPD_1270 Streptococcus pneumoniae D39 hypothetical protein YP_816736.1 1298661 R 373153 CDS YP_816737.1 116516931 4442046 complement(1298953..1299147) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1297; hypothetical protein 1299147 4442046 SPD_1271 Streptococcus pneumoniae D39 hypothetical protein YP_816737.1 1298953 R 373153 CDS YP_816738.1 116516078 4442535 complement(1299317..1299667) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1442; equivalent gene in S.pneumoniae R6 = spr1298; identified by match to protein family HMM PF05717; IS66 family Orf2 1299667 4442535 SPD_1272 Streptococcus pneumoniae D39 IS66 family Orf2 YP_816738.1 1299317 R 373153 CDS YP_816739.1 116517166 4441841 complement(1299648..1299887) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1443; equivalent gene in S.pneumoniae R6 = spr1299; IS66 family Orf1 1299887 4441841 SPD_1273 Streptococcus pneumoniae D39 IS66 family Orf1 YP_816739.1 1299648 R 373153 CDS YP_816740.1 116516474 4442944 complement(1300137..1301699) 1 NC_008533.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 1301699 guaA 4442944 guaA Streptococcus pneumoniae D39 GMP synthase YP_816740.1 1300137 R 373153 CDS YP_816741.1 116515468 4442638 1301841..1302539 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1446; equivalent gene in S.pneumoniae R6 = spr1301; identified by match to protein family HMM PF00392; match to protein family HMM PF07702; GntR family transcriptional regulator protein 1302539 4442638 SPD_1275 Streptococcus pneumoniae D39 GntR family transcriptional regulator protein YP_816741.1 1301841 D 373153 CDS YP_816742.1 116516351 4442953 complement(1302582..1303478) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1447; equivalent gene in S.pneumoniae R6 = spr1302; identified by match to protein family HMM PF00892; hypothetical protein 1303478 4442953 SPD_1276 Streptococcus pneumoniae D39 hypothetical protein YP_816742.1 1302582 R 373153 CDS YP_816743.1 116516560 4441265 complement(1303487..1304425) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1448; equivalent gene in S.pneumoniae R6 = spr1303; identified by match to protein family HMM PF00144; hypothetical protein 1304425 4441265 SPD_1277 Streptococcus pneumoniae D39 hypothetical protein YP_816743.1 1303487 R 373153 CDS YP_816744.1 116515759 4442415 complement(1304422..1305147) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1449; equivalent gene in S.pneumoniae R6 = spr1304; C3-degrading proteinase 1305147 cppA 4442415 cppA Streptococcus pneumoniae D39 C3-degrading proteinase YP_816744.1 1304422 R 373153 CDS YP_816745.1 116515324 4442667 complement(1305231..1305866) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1450; equivalent gene in S.pneumoniae R6 = spr1305; identified by match to protein family HMM PF00657; GDSL-like lipase/acylhydrolase 1305866 4442667 SPD_1279 Streptococcus pneumoniae D39 GDSL-like lipase/acylhydrolase YP_816745.1 1305231 R 373153 CDS YP_816746.1 116516695 4441369 complement(1305868..1306695) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1451; equivalent gene in S.pneumoniae R6 = spr1306; identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; Cof family protein 1306695 4441369 SPD_1280 Streptococcus pneumoniae D39 Cof family protein YP_816746.1 1305868 R 373153 CDS YP_816747.1 116515589 4441209 complement(1306717..1307052) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1452; equivalent gene in S.pneumoniae R6 = spr1307; hypothetical protein 1307052 4441209 SPD_1281 Streptococcus pneumoniae D39 hypothetical protein YP_816747.1 1306717 R 373153 CDS YP_816748.1 116515911 4442791 complement(1307053..1307565) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1453; equivalent gene in S.pneumoniae R6 = spr1308; hypothetical protein 1307565 4442791 SPD_1282 Streptococcus pneumoniae D39 hypothetical protein YP_816748.1 1307053 R 373153 CDS YP_816749.1 116516365 4443027 complement(1307659..1307781) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1454; hypothetical protein 1307781 4443027 SPD_1283 Streptococcus pneumoniae D39 hypothetical protein YP_816749.1 1307659 R 373153 CDS YP_816750.1 116515511 4442992 1307857..1307970 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1309; identified by similarity to GB:AAL001131; hypothetical protein 1307970 4442992 SPD_1284 Streptococcus pneumoniae D39 hypothetical protein YP_816750.1 1307857 D 373153 CDS YP_816751.1 116516110 4441635 1308294..1308905 1 NC_008533.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 1308905 def 4441635 def Streptococcus pneumoniae D39 peptide deformylase YP_816751.1 1308294 D 373153 CDS YP_816752.1 116516815 4442172 1308950..1309678 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1457; equivalent gene in S.pneumoniae R6 = spr1311; identified by match to protein family HMM PF00588; match to protein family HMM PF08032; match to protein family HMM TIGR00186; TrmH family RNA methyltransferase group 3 1309678 4442172 SPD_1286 Streptococcus pneumoniae D39 TrmH family RNA methyltransferase group 3 YP_816752.1 1308950 D 373153 CDS YP_816753.1 116516912 4442060 complement(1309717..1310628) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1458; equivalent gene in S.pneumoniae R6 = spr1312; identified by match to protein family HMM PF00070; match to protein family HMM PF01134; match to protein family HMM PF01266; match to protein family HMM PF03486; match to protein family HMM PF07992; match to protein family HMM TIGR01292; thioredoxin-disulfide reductase 1310628 trxB 4442060 trxB Streptococcus pneumoniae D39 thioredoxin-disulfide reductase YP_816753.1 1309717 R 373153 CDS YP_816754.1 116516132 4442220 complement(1310694..1310918) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1459; equivalent gene in S.pneumoniae R6 = spr1313; hypothetical protein 1310918 4442220 SPD_1288 Streptococcus pneumoniae D39 hypothetical protein YP_816754.1 1310694 R 373153 CDS YP_816755.1 116516709 4442335 complement(1310996..1311739) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1460; equivalent gene in S.pneumoniae R6 = spr1314; identified by match to protein family HMM PF00005; amino acid ABC transporter ATP-binding protein 1311739 4442335 SPD_1289 Streptococcus pneumoniae D39 amino acid ABC transporter ATP-binding protein YP_816755.1 1310996 R 373153 CDS YP_816756.1 116515947 4441349 complement(1311739..1312539) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1461; equivalent gene in S.pneumoniae R6 = spr1315; identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; amino acid ABC transporter permease 1312539 4441349 SPD_1290 Streptococcus pneumoniae D39 amino acid ABC transporter permease YP_816756.1 1311739 R 373153 CDS YP_816757.1 116515586 4441206 complement(1312697..1313053) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1462; equivalent gene in S.pneumoniae R6 = spr1316; identified by match to protein family HMM PF03960; match to protein family HMM TIGR01617; hypothetical protein 1313053 4441206 SPD_1291 Streptococcus pneumoniae D39 hypothetical protein YP_816757.1 1312697 R 373153 CDS YP_816758.1 116516710 4442336 complement(1313047..1313577) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1463; equivalent gene in S.pneumoniae R6 = spr1317; identified by match to protein family HMM PF01035; match to protein family HMM TIGR00589; methylated-DNA--protein-cysteine S-methyltransferase 1313577 ogt 4442336 ogt Streptococcus pneumoniae D39 methylated-DNA--protein-cysteine S-methyltransferase YP_816758.1 1313047 R 373153 CDS YP_816759.1 116515345 4441087 complement(1313577..1314071) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1464; equivalent gene in S.pneumoniae R6 = spr1318; identified by match to protein family HMM PF00583; GNAT family acetyltransferase 1314071 4441087 SPD_1293 Streptococcus pneumoniae D39 GNAT family acetyltransferase YP_816759.1 1313577 R 373153 CDS YP_816760.1 116516428 4441654 1314206..1314652 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1465; equivalent gene in S.pneumoniae R6 = spr1319; hypothetical protein 1314652 4441654 SPD_1294 Streptococcus pneumoniae D39 hypothetical protein YP_816760.1 1314206 D 373153 CDS YP_816761.1 116515763 4442419 1314649..1315296 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1466; equivalent gene in S.pneumoniae R6 = spr1320; identified by match to protein family HMM PF03006; match to protein family HMM TIGR01065; hemolysin 1315296 4442419 SPD_1295 Streptococcus pneumoniae D39 hemolysin YP_816761.1 1314649 D 373153 CDS YP_816762.1 116516892 4442077 complement(1315317..1315898) 1 NC_008533.1 with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate; glutamine amidotransferase subunit PdxT 1315898 4442077 SPD_1296 Streptococcus pneumoniae D39 glutamine amidotransferase subunit PdxT YP_816762.1 1315317 R 373153 CDS YP_816763.1 116515752 4442407 complement(1315899..1316774) 1 NC_008533.1 with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate; pyridoxal biosynthesis lyase PdxS 1316774 4442407 SPD_1297 Streptococcus pneumoniae D39 pyridoxal biosynthesis lyase PdxS YP_816763.1 1315899 R 373153 CDS YP_816764.1 116516669 4442449 complement(1316926..1318305) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1469; equivalent gene in S.pneumoniae R6 = spr1323; identified by match to protein family HMM PF00070; match to protein family HMM PF02852; match to protein family HMM PF07992; NADH oxidase 1318305 nox 4442449 nox Streptococcus pneumoniae D39 NADH oxidase YP_816764.1 1316926 R 373153 CDS YP_816765.1 116515401 4442471 1318447..1318602 1 NC_008533.1 hypothetical protein 1318602 4442471 SPD_1299 Streptococcus pneumoniae D39 hypothetical protein YP_816765.1 1318447 D 373153 CDS YP_816766.1 116516413 4442979 1318599..1319522 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1470; equivalent gene in S.pneumoniae R6 = spr1324; identified by match to protein family HMM PF02424; thiamine biosynthesis protein ApbE 1319522 4442979 SPD_1300 Streptococcus pneumoniae D39 thiamine biosynthesis protein ApbE YP_816766.1 1318599 D 373153 CDS YP_816767.1 116516114 4441639 1319582..1320187 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1471; equivalent gene in S.pneumoniae R6 = spr1325; identified by match to protein family HMM PF03358; NADPH-dependent FMN reductase 1320187 4441639 SPD_1301 Streptococcus pneumoniae D39 NADPH-dependent FMN reductase YP_816767.1 1319582 D 373153 CDS YP_816768.1 116517114 4441886 1320205..1321449 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1472; equivalent gene in S.pneumoniae R6 = spr1326; identified by match to protein family HMM PF03358; oxidoreductase 1321449 4441886 SPD_1302 Streptococcus pneumoniae D39 oxidoreductase YP_816768.1 1320205 D 373153 CDS YP_816769.1 116517108 4441880 complement(1321566..1321823) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1473; equivalent gene in S.pneumoniae R6 = spr1327; identified by match to protein family HMM PF05979; hypothetical protein 1321823 4441880 SPD_1303 Streptococcus pneumoniae D39 hypothetical protein YP_816769.1 1321566 R 373153 CDS YP_816770.1 116516232 4441512 complement(1321865..1323901) 1 NC_008533.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta 1323901 glyS 4441512 glyS Streptococcus pneumoniae D39 glycyl-tRNA synthetase subunit beta YP_816770.1 1321865 R 373153 CDS YP_816771.1 116516637 4441426 complement(1324161..1325078) 1 NC_008533.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha 1325078 glyQ 4441426 glyQ Streptococcus pneumoniae D39 glycyl-tRNA synthetase subunit alpha YP_816771.1 1324161 R 373153 CDS YP_816772.1 116516094 4442688 complement(1325272..1325661) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1476; equivalent gene in S.pneumoniae R6 = spr1330; hypothetical protein 1325661 4442688 SPD_1306 Streptococcus pneumoniae D39 hypothetical protein YP_816772.1 1325272 R 373153 CDS YP_816773.1 116515990 4441493 complement(1325643..1326032) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1477; equivalent gene in S.pneumoniae R6 = spr1331; hypothetical protein 1326032 4441493 SPD_1307 Streptococcus pneumoniae D39 hypothetical protein YP_816773.1 1325643 R 373153 CDS YP_816774.1 116516312 4442795 complement(1326305..1327147) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1478; equivalent gene in S.pneumoniae R6 = spr1332; identified by match to protein family HMM PF00248; oxidoreductase, aldo/keto reductase family protein 1327147 4442795 SPD_1308 Streptococcus pneumoniae D39 oxidoreductase, aldo/keto reductase family protein YP_816774.1 1326305 R 373153 CDS YP_816775.1 116515788 4441553 complement(1327261..1328703) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1479; equivalent gene in S.pneumoniae R6 = spr1333; identified by match to protein family HMM PF01522; peptidoglycan GlcNAc deacetylase 1328703 pgdA 4441553 pgdA Streptococcus pneumoniae D39 peptidoglycan GlcNAc deacetylase YP_816775.1 1327261 R 373153 CDS YP_816776.1 116517100 4441911 complement(1328887..1329132) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1480; equivalent gene in S.pneumoniae R6 = spr1334; hypothetical protein 1329132 4441911 SPD_1310 Streptococcus pneumoniae D39 hypothetical protein YP_816776.1 1328887 R 373153 CDS YP_816777.1 116516322 4442805 1329479..1330456 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1482; equivalent gene in S.pneumoniae R6 = spr1335; identified by match to protein family HMM PF01118; match to protein family HMM PF01408; oxidoreductase, Gfo/Idh/MocA family protein 1330456 4442805 SPD_1311 Streptococcus pneumoniae D39 oxidoreductase, Gfo/Idh/MocA family protein YP_816777.1 1329479 D 373153 CDS YP_816778.1 116516831 4442188 1330453..1331535 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1483; equivalent gene in S.pneumoniae R6 = spr1336; identified by match to protein family HMM PF00270; match to protein family HMM PF00271; ATP-dependent RNA helicase 1331535 4442188 SPD_1312 Streptococcus pneumoniae D39 ATP-dependent RNA helicase YP_816778.1 1330453 D 373153 CDS YP_816779.1 116516195 4441454 complement(1333510..1333848) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1487; equivalent gene in S.pneumoniae R6 = spr1342; hypothetical protein 1333848 4441454 SPD_1316 Streptococcus pneumoniae D39 hypothetical protein YP_816779.1 1333510 R 373153 CDS YP_816780.1 116516784 4442237 complement(1333971..1334111) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1488; hypothetical protein 1334111 4442237 SPD_1317 Streptococcus pneumoniae D39 hypothetical protein YP_816780.1 1333971 R 373153 CDS YP_816781.1 116515356 4441156 complement(1334495..1335691) 1 NC_008533.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 1335691 tuf 4441156 tuf Streptococcus pneumoniae D39 elongation factor Tu YP_816781.1 1334495 R 373153 CDS YP_816782.1 116517081 4441931 complement(1336034..1336156) 1 NC_008533.1 hypothetical protein 1336156 4441931 SPD_1319 Streptococcus pneumoniae D39 hypothetical protein YP_816782.1 1336034 R 373153 CDS YP_816783.1 116515599 4442738 complement(1336613..1337482) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1491; equivalent gene in S.pneumoniae R6 = spr1344; identified by match to protein family HMM PF00230; glycerol uptake facilitator protein 1337482 4442738 SPD_1320 Streptococcus pneumoniae D39 glycerol uptake facilitator protein YP_816783.1 1336613 R 373153 CDS YP_816784.1 116516354 4442956 complement(1337706..1338314) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1492; equivalent gene in S.pneumoniae R6 = spr1345; identified by match to protein family HMM PF00746; match to protein family HMM PF06458; match to protein family HMM TIGR01167; cell wall surface anchor family protein 1338314 4442956 SPD_1321 Streptococcus pneumoniae D39 cell wall surface anchor family protein YP_816784.1 1337706 R 373153 CDS YP_816785.1 116515377 4441613 complement(1338272..1339378) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1493; equivalent gene in S.pneumoniae R6 = spr1346; hypothetical protein 1339378 4441613 SPD_1322 Streptococcus pneumoniae D39 hypothetical protein YP_816785.1 1338272 R 373153 CDS YP_816786.1 116516722 4442310 complement(1339489..1339743) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1494; equivalent gene in S.pneumoniae R6 = spr1347; hypothetical protein 1339743 4442310 SPD_1323 Streptococcus pneumoniae D39 hypothetical protein YP_816786.1 1339489 R 373153 CDS YP_816787.1 116515663 4441246 complement(1340101..1340400) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1496; equivalent gene in S.pneumoniae R6 = spr1349; IS630-Spn1, transposase Orf2 1340400 4441246 SPD_1324 Streptococcus pneumoniae D39 IS630-Spn1, transposase Orf2 YP_816787.1 1340101 R 373153 CDS YP_816788.1 116515604 4442743 1341179..1342897 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1498; equivalent gene in S.pneumoniae R6 = spr1351; identified by match to protein family HMM PF00408; match to protein family HMM PF02878; match to protein family HMM PF02879; match to protein family HMM PF02880; phosphoglucomutase/phosphomannomutase family protein 1342897 pgm 4442743 pgm Streptococcus pneumoniae D39 phosphoglucomutase/phosphomannomutase family protein YP_816788.1 1341179 D 373153 CDS YP_816789.1 116516657 4443061 1343008..1343355 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1499; equivalent gene in S.pneumoniae R6 = spr1352; identified by match to protein family HMM TIGR01295; bacterocin transport accessory protein 1343355 bta 4443061 bta Streptococcus pneumoniae D39 bacterocin transport accessory protein YP_816789.1 1343008 D 373153 CDS YP_816790.1 116515532 4442897 complement(1343634..1344470) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1500; equivalent gene in S.pneumoniae R6 = spr1353; identified by match to protein family HMM PF00497; amino acid ABC transporter amino acid-binding protein 1344470 aatB 4442897 aatB Streptococcus pneumoniae D39 amino acid ABC transporter amino acid-binding protein YP_816790.1 1343634 R 373153 CDS YP_816791.1 116516161 4442835 complement(1344483..1345112) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1501; equivalent gene in S.pneumoniae R6 = spr1354; identified by match to protein family HMM PF00005; amino acid ABC transporter ATP-binding protein 1345112 4442835 SPD_1329 Streptococcus pneumoniae D39 amino acid ABC transporter ATP-binding protein YP_816791.1 1344483 R 373153 CDS YP_816792.1 116516529 4443080 complement(1345122..1345763) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1502; equivalent gene in S.pneumoniae R6 = spr1355; identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726; amino acid ABC transporter permease 1345763 4443080 SPD_1330 Streptococcus pneumoniae D39 amino acid ABC transporter permease YP_816792.1 1345122 R 373153 CDS YP_816793.1 116515949 4441351 complement(1345909..1347138) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1504; equivalent gene in S.pneumoniae R6 = spr1356; identified by match to protein family HMM PF00515; match to protein family HMM PF07719; hypothetical protein 1347138 4441351 SPD_1331 Streptococcus pneumoniae D39 hypothetical protein YP_816793.1 1345909 R 373153 CDS YP_816794.1 116517014 4441959 complement(1347128..1348294) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1505; equivalent gene in S.pneumoniae R6 = spr1357; identified by match to protein family HMM PF01594; hypothetical protein 1348294 4441959 SPD_1332 Streptococcus pneumoniae D39 hypothetical protein YP_816794.1 1347128 R 373153 CDS YP_816795.1 116515433 4441280 1348438..1349451 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1506; equivalent gene in S.pneumoniae R6 = spr1358; hypothetical protein 1349451 4441280 SPD_1333 Streptococcus pneumoniae D39 hypothetical protein YP_816795.1 1348438 D 373153 CDS YP_816796.1 116516397 4441604 complement(1349496..1349915) 1 NC_008533.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; F0F1 ATP synthase subunit epsilon 1349915 atpC 4441604 atpC Streptococcus pneumoniae D39 F0F1 ATP synthase subunit epsilon YP_816796.1 1349496 R 373153 CDS YP_816797.1 116516544 4441048 complement(1349926..1351332) 1 NC_008533.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; F0F1 ATP synthase subunit beta 1351332 atpD 4441048 atpD Streptococcus pneumoniae D39 F0F1 ATP synthase subunit beta YP_816797.1 1349926 R 373153 CDS YP_816798.1 116515905 4442785 complement(1351418..1352296) 1 NC_008533.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; F0F1 ATP synthase subunit gamma 1352296 atpG 4442785 atpG Streptococcus pneumoniae D39 F0F1 ATP synthase subunit gamma YP_816798.1 1351418 R 373153 CDS YP_816799.1 116517209 4441807 complement(1352312..1353817) 1 NC_008533.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; F0F1 ATP synthase subunit alpha 1353817 atpA 4441807 atpA Streptococcus pneumoniae D39 F0F1 ATP synthase subunit alpha YP_816799.1 1352312 R 373153 CDS YP_816800.1 116516143 4442505 complement(1353832..1354368) 1 NC_008533.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; F0F1 ATP synthase subunit delta 1354368 atpH 4442505 atpH Streptococcus pneumoniae D39 F0F1 ATP synthase subunit delta YP_816800.1 1353832 R 373153 CDS YP_816801.1 116515510 4442991 complement(1354368..1354862) 1 NC_008533.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; F0F1 ATP synthase subunit B 1354862 atpF 4442991 atpF Streptococcus pneumoniae D39 F0F1 ATP synthase subunit B YP_816801.1 1354368 R 373153 CDS YP_816802.1 116516382 4443045 complement(1354876..1355592) 1 NC_008533.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; F0F1 ATP synthase subunit A 1355592 atpB 4443045 atpB Streptococcus pneumoniae D39 F0F1 ATP synthase subunit A YP_816802.1 1354876 R 373153 CDS YP_816803.1 116515363 4441163 complement(1355627..1355827) 1 NC_008533.1 produces ATP from ADP in the presence of a proton gradient across the membrane; subunit C is part of the membrane proton channel F0; F0F1 ATP synthase subunit C 1355827 atpE 4441163 atpE Streptococcus pneumoniae D39 F0F1 ATP synthase subunit C YP_816803.1 1355627 R 373153 CDS YP_816804.1 116516748 4442298 complement(1355902..1356909) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0915; equivalent gene in S.pneumoniae R6 = spr1367; identified by match to protein family HMM PF00665; IS1239, transposase 1356909 4442298 SPD_1342 Streptococcus pneumoniae D39 IS1239, transposase YP_816804.1 1355902 R 373153 CDS YP_816805.1 116515322 4442665 complement(1357354..1357782) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1516; equivalent gene in S.pneumoniae R6 = spr1368; identified by match to protein family HMM PF00583; GNAT family acetyltransferase 1357782 4442665 SPD_1343 Streptococcus pneumoniae D39 GNAT family acetyltransferase YP_816805.1 1357354 R 373153 CDS YP_816806.1 116516910 4442058 complement(1357870..1358277) 1 NC_008533.1 hypothetical protein 1358277 4442058 SPD_1344 Streptococcus pneumoniae D39 hypothetical protein YP_816806.1 1357870 R 373153 CDS YP_816807.1 116516490 4443020 complement(1358305..1358787) 1 NC_008533.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA 1358787 greA 4443020 greA Streptococcus pneumoniae D39 transcription elongation factor GreA YP_816807.1 1358305 R 373153 CDS YP_816808.1 116515658 4441241 complement(1358858..1360513) 1 NC_008533.1 YceG family protein; equivalent gene in S.pneumoniae TIGR4 = SP1518; equivalent gene in S.pneumoniae R6 = spr1370; identified by match to protein family HMM PF02618; match to protein family HMM TIGR00247; COG1559; hypothetical protein 1360513 4441241 SPD_1346 Streptococcus pneumoniae D39 hypothetical protein YP_816808.1 1358858 R 373153 CDS YP_816809.1 116516733 4442322 complement(1360594..1361088) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1519; equivalent gene in S.pneumoniae R6 = spr1371; identified by match to protein family HMM PF00583; GNAT family acetyltransferase 1361088 4442322 SPD_1347 Streptococcus pneumoniae D39 GNAT family acetyltransferase YP_816809.1 1360594 R 373153 CDS YP_816810.1 116516267 4441777 complement(1361085..1361549) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1520; equivalent gene in S.pneumoniae R6 = spr1372; identified by match to protein family HMM PF00583; GNAT family acetyltransferase 1361549 4441777 SPD_1348 Streptococcus pneumoniae D39 GNAT family acetyltransferase YP_816810.1 1361085 R 373153 CDS YP_816811.1 116515384 4441620 complement(1361559..1362893) 1 NC_008533.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 1362893 murC 4441620 murC Streptococcus pneumoniae D39 UDP-N-acetylmuramate--L-alanine ligase YP_816811.1 1361559 R 373153 CDS YP_816812.1 116516012 4441574 complement(1362904..1363521) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1522; equivalent gene in S.pneumoniae R6 = spr1374; hypothetical protein 1363521 4441574 SPD_1350 Streptococcus pneumoniae D39 hypothetical protein YP_816812.1 1362904 R 373153 CDS YP_816813.1 116516877 4442120 complement(1363569..1366667) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1523; equivalent gene in S.pneumoniae R6 = spr1375; identified by match to protein family HMM PF00176; match to protein family HMM PF00271; match to protein family HMM PF04434; Snf2 family protein 1366667 4442120 SPD_1351 Streptococcus pneumoniae D39 Snf2 family protein YP_816813.1 1363569 R 373153 CDS YP_816814.1 116517089 4441900 complement(1366760..1367926) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1524; equivalent gene in S.pneumoniae R6 = spr1376; identified by match to protein family HMM PF00155; class II aminotransferase 1367926 4441900 SPD_1352 Streptococcus pneumoniae D39 class II aminotransferase YP_816814.1 1366760 R 373153 CDS YP_816815.1 116515921 4441064 complement(1367934..1369028) 1 NC_008533.1 catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; cystathionine gamma-synthase 1369028 4441064 SPD_1353 Streptococcus pneumoniae D39 cystathionine gamma-synthase YP_816815.1 1367934 R 373153 CDS YP_816816.1 116515397 4442467 complement(1369186..1369338) 1 NC_008533.1 This may be a degenerate gene resulting from mutation in the ATP-binding protein located just upstream. equivalent gene in S.pneumoniae R6 = spr1378; hypothetical protein 1369338 4442467 SPD_1354 Streptococcus pneumoniae D39 hypothetical protein YP_816816.1 1369186 R 373153 CDS YP_816817.1 116516505 4442626 complement(1369457..1369909) 1 NC_008533.1 This may be a degenerate gene resulting from mutations in an ATP-binding protein liberating the downstream gene. equivalent gene in S.pneumoniae R6 = spr1379; hypothetical protein 1369909 4442626 SPD_1355 Streptococcus pneumoniae D39 hypothetical protein YP_816817.1 1369457 R 373153 CDS YP_816818.1 116516101 4441626 complement(1371041..1372999) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1527; equivalent gene in S.pneumoniae R6 = spr1382; identified by match to protein family HMM PF00496; oligopeptide ABC transporter oligopeptide-binding protein AliB 1372999 aliB 4441626 aliB Streptococcus pneumoniae D39 oligopeptide ABC transporter oligopeptide-binding protein AliB YP_816818.1 1371041 R 373153 CDS YP_816819.1 116517110 4441882 complement(1373202..1374824) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1529; equivalent gene in S.pneumoniae R6 = spr1383; identified by match to protein family HMM PF01943; polysaccharide biosynthesis protein 1374824 4441882 SPD_1358 Streptococcus pneumoniae D39 polysaccharide biosynthesis protein YP_816819.1 1373202 R 373153 CDS YP_816820.1 116516282 4442610 1374930..1376375 1 NC_008533.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of lysine to UDP-N-acetylmuramoyl-L-alanyl-D-glutamate forming UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine; UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase 1376375 murE 4442610 murE Streptococcus pneumoniae D39 UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase YP_816820.1 1374930 D 373153 CDS YP_816821.1 116516418 4442984 complement(1376421..1376615) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1531; equivalent gene in S.pneumoniae R6 = spr1385; identified by match to protein family HMM PF05532; hypothetical protein 1376615 4442984 SPD_1360 Streptococcus pneumoniae D39 hypothetical protein YP_816821.1 1376421 R 373153 CDS YP_816822.1 116515986 4442438 complement(1377348..1377860) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1533; equivalent gene in S.pneumoniae R6 = spr1388; hypothetical protein 1377860 4442438 SPD_1362 Streptococcus pneumoniae D39 hypothetical protein YP_816822.1 1377348 R 373153 CDS YP_816823.1 116516825 4442182 complement(1377947..1378882) 1 NC_008533.1 catalyzes the hydrolysis of pyrophosphate to phosphate; manganese-dependent inorganic pyrophosphatase 1378882 ppaC 4442182 ppaC Streptococcus pneumoniae D39 manganese-dependent inorganic pyrophosphatase YP_816823.1 1377947 R 373153 CDS YP_816824.1 116515348 4441090 complement(1378953..1379252) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1535; equivalent gene in S.pneumoniae R6 = spr1390; identified by match to protein family HMM PF01541; hypothetical protein 1379252 4441090 SPD_1364 Streptococcus pneumoniae D39 hypothetical protein YP_816824.1 1378953 R 373153 CDS YP_816825.1 116516448 4442567 complement(1379242..1379991) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1536; equivalent gene in S.pneumoniae R6 = spr1391; identified by match to protein family HMM PF05175; hypothetical protein 1379991 4442567 SPD_1365 Streptococcus pneumoniae D39 hypothetical protein YP_816825.1 1379242 R 373153 CDS YP_816826.1 116516485 4443014 complement(1380045..1380404) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1537; equivalent gene in S.pneumoniae R6 = spr1392; identified by match to protein family HMM PF00575; hypothetical protein 1380404 4443014 SPD_1366 Streptococcus pneumoniae D39 hypothetical protein YP_816826.1 1380045 R 373153 CDS YP_816827.1 116515578 4442888 complement(1380406..1381806) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1538; equivalent gene in S.pneumoniae R6 = spr1393; identified by match to protein family HMM PF00160; match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; Cof family protein/peptidyl-prolyl cis-trans isomerase 1381806 4442888 SPD_1367 Streptococcus pneumoniae D39 Cof family protein/peptidyl-prolyl cis-trans isomerase YP_816827.1 1380406 R 373153 CDS YP_816828.1 116516750 4442300 complement(1382101..1382340) 1 NC_008533.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 1382340 rpsR 4442300 rpsR Streptococcus pneumoniae D39 30S ribosomal protein S18 YP_816828.1 1382101 R 373153 CDS YP_816829.1 116516879 4442122 complement(1382372..1382842) 1 NC_008533.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein 1382842 ssb 4442122 ssb Streptococcus pneumoniae D39 single-stranded DNA-binding protein YP_816829.1 1382372 R 373153 CDS YP_816830.1 116516740 4442290 complement(1382854..1383144) 1 NC_008533.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 1383144 rpsF 4442290 rpsF Streptococcus pneumoniae D39 30S ribosomal protein S6 YP_816830.1 1382854 R 373153 CDS YP_816831.1 116515635 4441315 complement(1383297..1384640) 1 NC_008533.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; asparaginyl-tRNA synthetase 1384640 asnC 4441315 asnC Streptococcus pneumoniae D39 asparaginyl-tRNA synthetase YP_816831.1 1383297 R 373153 CDS YP_816832.1 116515820 4442868 complement(1384659..1385024) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1398; identified by match to protein family HMM PF00903; glyoxalase family protein 1385024 4442868 SPD_1372 Streptococcus pneumoniae D39 glyoxalase family protein YP_816832.1 1384659 R 373153 CDS YP_816833.1 116516335 4442818 complement(1385017..1386204) 1 NC_008533.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate; aspartate aminotransferase 1386204 aspC 4442818 aspC Streptococcus pneumoniae D39 aspartate aminotransferase YP_816833.1 1385017 R 373153 CDS YP_816834.1 116516103 4441628 complement(1386201..1386632) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1545; equivalent gene in S.pneumoniae R6 = spr1400; identified by match to protein family HMM PF03413; hypothetical protein 1386632 4441628 SPD_1374 Streptococcus pneumoniae D39 hypothetical protein YP_816834.1 1386201 R 373153 CDS YP_816835.1 116517197 4441834 1387010..1387558 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1546; equivalent gene in S.pneumoniae R6 = spr1402; identified by match to protein family HMM PF02525; match to protein family HMM PF03358; hypothetical protein 1387558 4441834 SPD_1375 Streptococcus pneumoniae D39 hypothetical protein YP_816835.1 1387010 D 373153 CDS YP_816836.1 116515899 4442779 complement(1387796..1395451) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1403; identified by match to protein family HMM PF01391; match to protein family HMM PF04650; match to protein family HMM PF07501; match to protein family HMM PF07554; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; G5 domain-containing protein 1395451 4442779 SPD_1376 Streptococcus pneumoniae D39 G5 domain-containing protein YP_816836.1 1387796 R 373153 CDS YP_816837.1 116516572 4442093 1395667..1397151 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1404; identified by match to protein family HMM PF05043; hypothetical protein 1397151 4442093 SPD_1377 Streptococcus pneumoniae D39 hypothetical protein YP_816837.1 1395667 D 373153 CDS YP_816838.1 116516903 4442088 complement(1397202..1397930) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1547; equivalent gene in S.pneumoniae R6 = spr1405; identified by match to protein family HMM PF03883; hypothetical protein 1397930 4442088 SPD_1378 Streptococcus pneumoniae D39 hypothetical protein YP_816838.1 1397202 R 373153 CDS YP_816839.1 116515817 4442864 complement(1398009..1398173) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1406; hypothetical protein 1398173 4442864 SPD_1379 Streptococcus pneumoniae D39 hypothetical protein YP_816839.1 1398009 R 373153 CDS YP_816840.1 116517106 4441878 complement(1398340..1399935) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1548; equivalent gene in S.pneumoniae R6 = spr1407; hypothetical protein 1399935 4441878 SPD_1380 Streptococcus pneumoniae D39 hypothetical protein YP_816840.1 1398340 R 373153 CDS YP_816841.1 116515494 4441304 complement(1399947..1400357) 1 NC_008533.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 1400357 def-2 4441304 def-2 Streptococcus pneumoniae D39 peptide deformylase YP_816841.1 1399947 R 373153 CDS YP_816842.1 116516324 4442807 complement(1400473..1401264) 1 NC_008533.1 YghU; B2989; one of eight glutathione transferase proteins from E. coli; glutathione S-transferase 1401264 4442807 SPD_1382 Streptococcus pneumoniae D39 glutathione S-transferase YP_816842.1 1400473 R 373153 CDS YP_816843.1 116516314 4442797 complement(1401277..1403973) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1551; equivalent gene in S.pneumoniae R6 = spr1410; identified by match to protein family HMM PF00122; match to protein family HMM PF00689; match to protein family HMM PF00690; match to protein family HMM PF00702; match to protein family HMM TIGR01494; cation-transporting ATPase, E1-E2 family protein 1403973 4442797 SPD_1383 Streptococcus pneumoniae D39 cation-transporting ATPase, E1-E2 family protein YP_816843.1 1401277 R 373153 CDS YP_816844.1 116517171 4441846 1404277..1405461 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1552; equivalent gene in S.pneumoniae R6 = spr1411; identified by match to protein family HMM PF01545; match to protein family HMM TIGR01297; cation efflux family protein 1405461 4441846 SPD_1384 Streptococcus pneumoniae D39 cation efflux family protein YP_816844.1 1404277 D 373153 CDS YP_816845.1 116516141 4442503 complement(1405604..1407475) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1553; equivalent gene in S.pneumoniae R6 = spr1412; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1407475 4442503 SPD_1385 Streptococcus pneumoniae D39 ABC transporter ATP-binding protein YP_816845.1 1405604 R 373153 CDS YP_816846.1 116517000 4441984 complement(1407472..1408656) 1 NC_008533.1 catalyzes the addition and repair of the 3'-terminal CCA sequence in tRNA; these proteins belong to the CCA-adding enzyme subfamily 2 which does not have phosphohydrolase activity; tRNA CCA-pyrophosphorylase 1408656 4441984 SPD_1386 Streptococcus pneumoniae D39 tRNA CCA-pyrophosphorylase YP_816846.1 1407472 R 373153 CDS YP_816847.1 116515624 4442704 complement(1408668..1409435) 1 NC_008533.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase 1409435 dapB 4442704 dapB Streptococcus pneumoniae D39 dihydrodipicolinate reductase YP_816847.1 1408668 R 373153 CDS YP_816848.1 116516817 4442174 complement(1409712..1410560) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1557; equivalent gene in S.pneumoniae R6 = spr1415; identified by match to protein family HMM PF02645; match to protein family HMM TIGR00762; DegV family protein 1410560 4442174 SPD_1388 Streptococcus pneumoniae D39 DegV family protein YP_816848.1 1409712 R 373153 CDS YP_816849.1 116515411 4442481 complement(1410562..1410936) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1558; equivalent gene in S.pneumoniae R6 = spr1416; identified by match to protein family HMM PF06619; hypothetical protein 1410936 4442481 SPD_1389 Streptococcus pneumoniae D39 hypothetical protein YP_816849.1 1410562 R 373153 CDS YP_816850.1 116516422 4441648 complement(1411010..1412362) 1 NC_008533.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase 1412362 glmM 4441648 glmM Streptococcus pneumoniae D39 phosphoglucosamine mutase YP_816850.1 1411010 R 373153 CDS YP_816851.1 116517073 4441923 complement(1412386..1413165) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1560; equivalent gene in S.pneumoniae R6 = spr1418; identified by match to protein family HMM PF07949; hypothetical protein 1413165 4441923 SPD_1391 Streptococcus pneumoniae D39 hypothetical protein YP_816851.1 1412386 R 373153 CDS YP_816852.1 116516268 4441778 complement(1413152..1413967) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1561; equivalent gene in S.pneumoniae R6 = spr1419; identified by match to protein family HMM PF02457; match to protein family HMM TIGR00159; hypothetical protein 1413967 4441778 SPD_1392 Streptococcus pneumoniae D39 hypothetical protein YP_816852.1 1413152 R 373153 CDS YP_816853.1 116516331 4442814 1414145..1415113 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1563; equivalent gene in S.pneumoniae R6 = spr1421; identified by match to protein family HMM PF00070; match to protein family HMM PF03486; match to protein family HMM PF07992; pyridine nucleotide-disulfide oxidoreductase family protein 1415113 4442814 SPD_1393 Streptococcus pneumoniae D39 pyridine nucleotide-disulfide oxidoreductase family protein YP_816853.1 1414145 D 373153 CDS YP_816854.1 116515514 4442995 complement(1415147..1416058) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1564; equivalent gene in S.pneumoniae R6 = spr1422; identified by match to protein family HMM PF02650; match to protein family HMM TIGR00647; COG1481; hypothetical protein 1416058 4442995 SPD_1394 Streptococcus pneumoniae D39 hypothetical protein YP_816854.1 1415147 R 373153 CDS YP_816855.1 116516455 4442575 complement(1416055..1417032) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1565; equivalent gene in S.pneumoniae R6 = spr1423; identified by match to protein family HMM PF01933; match to protein family HMM TIGR01826; hypothetical protein 1417032 4442575 SPD_1395 Streptococcus pneumoniae D39 hypothetical protein YP_816855.1 1416055 R 373153 CDS YP_816856.1 116515346 4441088 complement(1417029..1417919) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1566; equivalent gene in S.pneumoniae R6 = spr1424; identified by match to protein family HMM PF03668; hypothetical protein 1417919 4441088 SPD_1396 Streptococcus pneumoniae D39 hypothetical protein YP_816856.1 1417029 R 373153 CDS YP_816857.1 116516493 4443023 complement(1417971..1418351) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1567; equivalent gene in S.pneumoniae R6 = spr1425; identified by match to protein family HMM PF01042; match to protein family HMM TIGR00004; endoribonuclease L-PSP 1418351 4443023 SPD_1397 Streptococcus pneumoniae D39 endoribonuclease L-PSP YP_816857.1 1417971 R 373153 CDS YP_816858.1 116515393 4442463 complement(1418362..1418949) 1 NC_008533.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC 1418949 engB 4442463 engB Streptococcus pneumoniae D39 ribosome biogenesis GTP-binding protein YsxC YP_816858.1 1418362 R 373153 CDS YP_816859.1 116517127 4442365 complement(1418958..1420190) 1 NC_008533.1 binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 1420190 clpX 4442365 clpX Streptococcus pneumoniae D39 ATP-dependent protease ATP-binding subunit ClpX YP_816859.1 1418958 R 373153 CDS YP_816860.1 116516044 4441704 complement(1420222..1420392) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1570; equivalent gene in S.pneumoniae R6 = spr1428; hypothetical protein 1420392 4441704 SPD_1400 Streptococcus pneumoniae D39 hypothetical protein YP_816860.1 1420222 R 373153 CDS YP_816861.1 116516966 4442919 complement(1420392..1420898) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1571; equivalent gene in S.pneumoniae R6 = spr1429; identified by match to protein family HMM PF00186; dihydrofolate reductase 1420898 folA 4442919 folA Streptococcus pneumoniae D39 dihydrofolate reductase YP_816861.1 1420392 R 373153 CDS YP_816862.1 116515815 4442862 complement(1421028..1421546) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1572; equivalent gene in S.pneumoniae R6 = spr1430; identified by match to protein family HMM PF00210; non-heme iron-containing ferritin 1421546 4442862 SPD_1402 Streptococcus pneumoniae D39 non-heme iron-containing ferritin YP_816862.1 1421028 R 373153 CDS YP_816863.1 116515853 4441545 complement(1422042..1423514) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1573; equivalent gene in S.pneumoniae R6 = spr1431; identified by match to protein family HMM PF01183; match to protein family HMM PF01473; 1,4-beta-N-acetylmuramidase 1423514 lytC 4441545 lytC Streptococcus pneumoniae D39 1,4-beta-N-acetylmuramidase YP_816863.1 1422042 R 373153 CDS YP_816864.1 116516798 4442193 complement(1423585..1424343) 1 NC_008533.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 1424343 tpiA 4442193 tpiA Streptococcus pneumoniae D39 triosephosphate isomerase YP_816864.1 1423585 R 373153 CDS YP_816865.1 116516031 4441691 complement(1424441..1425118) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1575; equivalent gene in S.pneumoniae R6 = spr1433; identified by match to protein family HMM PF04271; match to protein family HMM TIGR01446; hypothetical protein 1425118 4441691 SPD_1405 Streptococcus pneumoniae D39 hypothetical protein YP_816865.1 1424441 R 373153 CDS YP_816866.1 116516883 4442126 complement(1425127..1426071) 1 NC_008533.1 catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis; homoserine O-succinyltransferase 1426071 metA 4442126 metA Streptococcus pneumoniae D39 homoserine O-succinyltransferase YP_816866.1 1425127 R 373153 CDS YP_816867.1 116516257 4441767 complement(1426253..1426783) 1 NC_008533.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 1426783 apt 4441767 apt Streptococcus pneumoniae D39 adenine phosphoribosyltransferase YP_816867.1 1426253 R 373153 CDS YP_816868.1 116517093 4441904 complement(1426853..1427611) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1578; equivalent gene in S.pneumoniae R6 = spr1436; hypothetical protein 1427611 4441904 SPD_1408 Streptococcus pneumoniae D39 hypothetical protein YP_816868.1 1426853 R 373153 CDS YP_816869.1 116515506 4442987 complement(1428112..1429242) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1580; equivalent gene in S.pneumoniae R6 = spr1437; identified by match to protein family HMM PF00005; match to protein family HMM PF03459; sugar ABC transporter ATP-binding protein 1429242 4442987 SPD_1409 Streptococcus pneumoniae D39 sugar ABC transporter ATP-binding protein YP_816869.1 1428112 R 373153 CDS YP_816870.1 116516385 4441590 complement(1429692..1430267) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1583; equivalent gene in S.pneumoniae R6 = spr1438; identified by match to protein family HMM PF00857; isochorismatase family protein 1430267 4441590 SPD_1411 Streptococcus pneumoniae D39 isochorismatase family protein YP_816870.1 1429692 R 373153 CDS YP_816871.1 116515749 4442404 complement(1430267..1431055) 1 NC_008533.1 CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase (By similarity). It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor; transcriptional repressor CodY 1431055 codY 4442404 codY Streptococcus pneumoniae D39 transcriptional repressor CodY YP_816871.1 1430267 R 373153 CDS YP_816872.1 116516011 4441573 complement(1431319..1432893) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1586; equivalent gene in S.pneumoniae R6 = spr1440; identified by match to protein family HMM PF00270; match to protein family HMM PF00271; ATP-dependent RNA helicase 1432893 4441573 SPD_1413 Streptococcus pneumoniae D39 ATP-dependent RNA helicase YP_816872.1 1431319 R 373153 CDS YP_816873.1 116516469 4442939 complement(1433092..1434318) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1587; equivalent gene in S.pneumoniae R6 = spr1441; identified by match to protein family HMM PF07690; oxalate/formate antiporter 1434318 4442939 SPD_1414 Streptococcus pneumoniae D39 oxalate/formate antiporter YP_816873.1 1433092 R 373153 CDS YP_816874.1 116515420 4442490 1434508..1435824 1 NC_008533.1 Involved in disulfide oxidoreductase activity and electron transport; pyridine nucleotide-disulfide oxidoreductase 1435824 4442490 SPD_1415 Streptococcus pneumoniae D39 pyridine nucleotide-disulfide oxidoreductase YP_816874.1 1434508 D 373153 CDS YP_816875.1 116516543 4441046 1435923..1437266 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1589; equivalent gene in S.pneumoniae R6 = spr1443; hypothetical protein 1437266 4441046 SPD_1416 Streptococcus pneumoniae D39 hypothetical protein YP_816875.1 1435923 D 373153 CDS YP_816876.1 116515943 4441345 1437266..1438048 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1590; equivalent gene in S.pneumoniae R6 = spr1444; identified by match to protein family HMM PF07685; hypothetical protein 1438048 4441345 SPD_1417 Streptococcus pneumoniae D39 hypothetical protein YP_816876.1 1437266 D 373153 CDS YP_816877.1 116516123 4442210 1438174..1439256 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1591; equivalent gene in S.pneumoniae R6 = spr1445; identified by match to protein family HMM PF00557; proline dipeptidase PepQ 1439256 pepQ 4442210 pepQ Streptococcus pneumoniae D39 proline dipeptidase PepQ YP_816877.1 1438174 D 373153 CDS YP_816878.1 116517192 4441829 1439249..1439452 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1592; hypothetical protein 1439452 4441829 SPD_1419 Streptococcus pneumoniae D39 hypothetical protein YP_816878.1 1439249 D 373153 CDS YP_816879.1 116515766 4441666 complement(1441071..1441532) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1597; equivalent gene in S.pneumoniae R6 = spr1449; hypothetical protein 1441532 4441666 SPD_1422 Streptococcus pneumoniae D39 hypothetical protein YP_816879.1 1441071 R 373153 CDS YP_816880.1 116516841 4442161 complement(1441510..1442283) 1 NC_008533.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase 1442283 4442161 SPD_1423 Streptococcus pneumoniae D39 phosphomethylpyrimidine kinase YP_816880.1 1441510 R 373153 CDS YP_816881.1 116516785 4442238 complement(1442273..1443022) 1 NC_008533.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A 1443022 truA 4442238 truA Streptococcus pneumoniae D39 tRNA pseudouridine synthase A YP_816881.1 1442273 R 373153 CDS YP_816882.1 116515935 4441337 complement(1443335..1444486) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1600; equivalent gene in S.pneumoniae R6 = spr1453; identified by match to protein family HMM PF07690; transporter major facilitator family protein 1444486 4441337 SPD_1425 Streptococcus pneumoniae D39 transporter major facilitator family protein YP_816882.1 1443335 R 373153 CDS YP_816883.1 116516383 4441588 complement(1444726..1445355) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1601; equivalent gene in S.pneumoniae R6 = spr1454; hypothetical protein 1445355 4441588 SPD_1426 Streptococcus pneumoniae D39 hypothetical protein YP_816883.1 1444726 R 373153 CDS YP_816884.1 116516386 4441591 complement(1445358..1445696) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1602; equivalent gene in S.pneumoniae R6 = spr1455; identified by match to protein family HMM PF03831; match to protein family HMM TIGR00686; PhnA protein 1445696 phnA 4441591 phnA Streptococcus pneumoniae D39 PhnA protein YP_816884.1 1445358 R 373153 CDS YP_816885.1 116515618 4442698 complement(1445827..1446498) 1 NC_008533.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 1446498 cmk 4442698 cmk Streptococcus pneumoniae D39 cytidylate kinase YP_816885.1 1445827 R 373153 CDS YP_816886.1 116516758 4442269 complement(1446507..1446983) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1604; equivalent gene in S.pneumoniae R6 = spr1457; hypothetical protein 1446983 4442269 SPD_1429 Streptococcus pneumoniae D39 hypothetical protein YP_816886.1 1446507 R 373153 CDS YP_816887.1 116515900 4442780 1447035..1447241 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1605; equivalent gene in S.pneumoniae R6 = spr1458; ferredoxin 1447241 fer 4442780 fer Streptococcus pneumoniae D39 ferredoxin YP_816887.1 1447035 D 373153 CDS YP_816888.1 116515490 4441300 complement(1447303..1448256) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1606; equivalent gene in S.pneumoniae R6 = spr1459; identified by match to protein family HMM PF00535; glycosyl transferase family protein 1448256 4441300 SPD_1431 Streptococcus pneumoniae D39 glycosyl transferase family protein YP_816888.1 1447303 R 373153 CDS YP_816889.1 116516336 4442819 complement(1448258..1449277) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1607; equivalent gene in S.pneumoniae R6 = spr1460; identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF04321; match to protein family HMM PF07993; match to protein family HMM TIGR01179; UDP-glucose 4-epimerase 1449277 galE-1 4442819 galE-1 Streptococcus pneumoniae D39 UDP-glucose 4-epimerase YP_816889.1 1448258 R 373153 CDS YP_816890.1 116516255 4441765 complement(1449578..1450681) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1608; equivalent gene in S.pneumoniae R6 = spr1461; identified by match to protein family HMM PF01266; FAD dependent oxidoreductase 1450681 4441765 SPD_1433 Streptococcus pneumoniae D39 FAD dependent oxidoreductase YP_816890.1 1449578 R 373153 CDS YP_816891.1 116517031 4442345 complement(1450698..1451495) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1609; equivalent gene in S.pneumoniae R6 = spr1462; identified by match to protein family HMM PF01784; match to protein family HMM TIGR00486; hypothetical protein 1451495 4442345 SPD_1434 Streptococcus pneumoniae D39 hypothetical protein YP_816891.1 1450698 R 373153 CDS YP_816892.1 116515616 4442696 complement(1451482..1452159) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1610; equivalent gene in S.pneumoniae R6 = spr1463; identified by match to protein family HMM PF04816; hypothetical protein 1452159 4442696 SPD_1435 Streptococcus pneumoniae D39 hypothetical protein YP_816892.1 1451482 R 373153 CDS YP_816893.1 116515937 4441339 complement(1452261..1454597) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1623; equivalent gene in S.pneumoniae R6 = spr1464; identified by match to protein family HMM PF00122; match to protein family HMM PF00702; match to protein family HMM TIGR01494; cation-transporting ATPase, E1-E2 family protein 1454597 4441339 SPD_1436 Streptococcus pneumoniae D39 cation-transporting ATPase, E1-E2 family protein YP_816893.1 1452261 R 373153 CDS YP_816894.1 116515478 4442648 1454730..1455479 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1624; equivalent gene in S.pneumoniae R6 = spr1465; identified by match to protein family HMM PF01553; acyltransferase domain-containing protein 1455479 4442648 SPD_1437 Streptococcus pneumoniae D39 acyltransferase domain-containing protein YP_816894.1 1454730 D 373153 CDS YP_816895.1 116516294 4442583 complement(1455772..1456386) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1625; equivalent gene in S.pneumoniae R6 = spr1466; identified by match to protein family HMM PF03596; match to protein family HMM TIGR00779; cadmium resistance transporter 1456386 4442583 SPD_1438 Streptococcus pneumoniae D39 cadmium resistance transporter YP_816895.1 1455772 R 373153 CDS YP_816896.1 116517150 4441864 complement(1457120..1457389) 1 NC_008533.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 1457389 rpsO 4441864 rpsO Streptococcus pneumoniae D39 30S ribosomal protein S15 YP_816896.1 1457120 R 373153 CDS YP_816897.1 116516085 4442679 complement(1457530..1458159) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1627; equivalent gene in S.pneumoniae R6 = spr1468; hypothetical protein 1458159 4442679 SPD_1440 Streptococcus pneumoniae D39 hypothetical protein YP_816897.1 1457530 R 373153 CDS YP_816898.1 116516356 4442958 1458222..1458344 1 NC_008533.1 hypothetical protein 1458344 4442958 SPD_1441 Streptococcus pneumoniae D39 hypothetical protein YP_816898.1 1458222 D 373153 CDS YP_816899.1 116515517 4442998 1458963..1459169 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1630; equivalent gene in S.pneumoniae R6 = spr1470; hypothetical protein 1459169 4442998 SPD_1442 Streptococcus pneumoniae D39 hypothetical protein YP_816899.1 1458963 D 373153 CDS YP_816900.1 116517071 4441921 1459176..1459352 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1630; equivalent gene in S.pneumoniae R6 = spr1471; hypothetical protein 1459352 4441921 SPD_1443 Streptococcus pneumoniae D39 hypothetical protein YP_816900.1 1459176 D 373153 CDS YP_816901.1 116515338 4441080 1459410..1461353 1 NC_008533.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); threonyl-tRNA synthetase 1461353 thrS 4441080 thrS Streptococcus pneumoniae D39 threonyl-tRNA synthetase YP_816901.1 1459410 D 373153 CDS YP_816902.1 116516868 4442111 complement(1461402..1462376) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1632; equivalent gene in S.pneumoniae R6 = spr1473; identified by match to protein family HMM PF02518; sensor histidine kinase 1462376 4442111 SPD_1445 Streptococcus pneumoniae D39 sensor histidine kinase YP_816902.1 1461402 R 373153 CDS YP_816903.1 116516130 4442218 complement(1462369..1463046) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1633; equivalent gene in S.pneumoniae R6 = spr1474; identified by match to protein family HMM PF00072; match to protein family HMM PF00486; DNA-binding response regulator 1463046 4442218 SPD_1446 Streptococcus pneumoniae D39 DNA-binding response regulator YP_816903.1 1462369 R 373153 CDS YP_816904.1 116516926 4442038 1463202..1464275 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1634; equivalent gene in S.pneumoniae R6 = spr1475; hypothetical protein 1464275 4442038 SPD_1447 Streptococcus pneumoniae D39 hypothetical protein YP_816904.1 1463202 D 373153 CDS YP_816905.1 116515825 4441116 complement(1464737..1465174) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1636; equivalent gene in S.pneumoniae R6 = spr1477; identified by match to protein family HMM PF02082; Rrf2 family protein 1465174 4441116 SPD_1448 Streptococcus pneumoniae D39 Rrf2 family protein YP_816905.1 1464737 R 373153 CDS YP_816906.1 116515688 4442554 complement(1465250..1466092) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1637; equivalent gene in S.pneumoniae R6 = spr1479; identified by match to protein family HMM PF00149; hypothetical protein 1466092 4442554 SPD_1449 Streptococcus pneumoniae D39 hypothetical protein YP_816906.1 1465250 R 373153 CDS YP_816907.1 116516746 4442296 1466204..1466854 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1638; equivalent gene in S.pneumoniae R6 = spr1480; identified by match to protein family HMM PF01047; match to protein family HMM PF01325; match to protein family HMM PF02742; match to protein family HMM PF04023; iron-dependent transcriptional regulator 1466854 4442296 SPD_1450 Streptococcus pneumoniae D39 iron-dependent transcriptional regulator YP_816907.1 1466204 D 373153 CDS YP_816908.1 116517144 4442382 1466835..1467005 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1481; hypothetical protein 1467005 4442382 SPD_1451 Streptococcus pneumoniae D39 hypothetical protein YP_816908.1 1466835 D 373153 CDS YP_816909.1 116516107 4441632 1467156..1467548 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1482; hypothetical protein 1467548 4441632 SPD_1452 Streptococcus pneumoniae D39 hypothetical protein YP_816909.1 1467156 D 373153 CDS YP_816910.1 116516358 4442960 1467807..1468244 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1641; equivalent gene in S.pneumoniae R6 = spr1483; hypothetical protein 1468244 4442960 SPD_1454 Streptococcus pneumoniae D39 hypothetical protein YP_816910.1 1467807 D 373153 CDS YP_816911.1 116515424 4442494 1469540..1469653 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1642 This gene has a frameshift relative to the TIGR4 SP1642 gene.; hypothetical protein 1469653 4442494 SPD_1455 Streptococcus pneumoniae D39 hypothetical protein YP_816911.1 1469540 D 373153 CDS YP_816912.1 116516460 4442930 1469793..1469954 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1643; equivalent gene in S.pneumoniae R6 = spr1485; hypothetical protein 1469954 4442930 SPD_1456 Streptococcus pneumoniae D39 hypothetical protein YP_816912.1 1469793 D 373153 CDS YP_816913.1 116515633 4442713 complement(1469993..1470436) 1 NC_008533.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase 1470436 dtd 4442713 dtd Streptococcus pneumoniae D39 D-tyrosyl-tRNA(Tyr) deacylase YP_816913.1 1469993 R 373153 CDS YP_816914.1 116516708 4442334 complement(1470466..1472688) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1645; equivalent gene in S.pneumoniae R6 = spr1487; identified by match to protein family HMM PF01842; match to protein family HMM PF01966; match to protein family HMM PF02824; match to protein family HMM PF04607; match to protein family HMM TIGR00691; GTP pyrophosphokinase 1472688 relA 4442334 relA Streptococcus pneumoniae D39 GTP pyrophosphokinase YP_816914.1 1470466 R 373153 CDS YP_816915.1 116515803 4441568 1473683..1474312 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1646; equivalent gene in S.pneumoniae R6 = spr1490; identified by match to protein family HMM PF00753; metallo-beta-lactamase superfamily protein 1474312 4441568 SPD_1459 Streptococcus pneumoniae D39 metallo-beta-lactamase superfamily protein YP_816915.1 1473683 D 373153 CDS YP_816916.1 116517102 4441913 complement(1474435..1476327) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1647; equivalent gene in S.pneumoniae R6 = spr1491; identified by match to protein family HMM PF01431; match to protein family HMM PF05649; endopeptidase O 1476327 pepO 4441913 pepO Streptococcus pneumoniae D39 endopeptidase O YP_816916.1 1474435 R 373153 CDS YP_816917.1 116515895 4442774 1476618..1477340 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1648; equivalent gene in S.pneumoniae R6 = spr1492; identified by match to protein family HMM PF00005; manganese ABC transporter ATP-binding protein 1477340 psaB 4442774 psaB Streptococcus pneumoniae D39 manganese ABC transporter ATP-binding protein YP_816917.1 1476618 D 373153 CDS YP_816918.1 116516771 4442282 1477337..1478185 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1649; equivalent gene in S.pneumoniae R6 = spr1493; identified by match to protein family HMM PF00950; manganese ABC transporter permease 1478185 psaC 4442282 psaC Streptococcus pneumoniae D39 manganese ABC transporter permease YP_816918.1 1477337 D 373153 CDS YP_816919.1 116515973 4442424 1478217..1479146 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1650; equivalent gene in S.pneumoniae R6 = spr1494; identified by match to protein family HMM PF01297; ABC transporter substrate-binding protein 1479146 4442424 SPD_1463 Streptococcus pneumoniae D39 ABC transporter substrate-binding protein YP_816919.1 1478217 D 373153 CDS YP_816920.1 116517151 4441865 1479269..1479760 1 NC_008533.1 antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase 1479760 tpx 4441865 tpx Streptococcus pneumoniae D39 thiol peroxidase YP_816920.1 1479269 D 373153 CDS YP_816921.1 116516046 4442755 complement(1479856..1482564) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1652; equivalent gene in S.pneumoniae R6 = spr1496; identified by match to protein family HMM PF02687; hypothetical protein 1482564 4442755 SPD_1465 Streptococcus pneumoniae D39 hypothetical protein YP_816921.1 1479856 R 373153 CDS YP_816922.1 116516416 4442982 complement(1482566..1483267) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1653; equivalent gene in S.pneumoniae R6 = spr1497; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1483267 4442982 SPD_1466 Streptococcus pneumoniae D39 ABC transporter ATP-binding protein YP_816922.1 1482566 R 373153 CDS YP_816923.1 116515332 4442675 complement(1483517..1485928) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1654; equivalent gene in S.pneumoniae R6 = spr1498; hypothetical protein 1485928 4442675 SPD_1467 Streptococcus pneumoniae D39 hypothetical protein YP_816923.1 1483517 R 373153 CDS YP_816924.1 116516661 4442440 complement(1485981..1486673) 1 NC_008533.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase 1486673 gpmA 4442440 gpmA Streptococcus pneumoniae D39 phosphoglyceromutase YP_816924.1 1485981 R 373153 CDS YP_816925.1 116515642 4441322 complement(1486724..1486912) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1656; equivalent gene in S.pneumoniae R6 = spr1500; hypothetical protein 1486912 4441322 SPD_1469 Streptococcus pneumoniae D39 hypothetical protein YP_816925.1 1486724 R 373153 CDS YP_816926.1 116516001 4441505 complement(1487288..1487428) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1658; equivalent gene in S.pneumoniae R6 = spr1501; hypothetical protein 1487428 4441505 SPD_1470 Streptococcus pneumoniae D39 hypothetical protein YP_816926.1 1487288 R 373153 CDS YP_816927.1 116517203 4441801 complement(1487432..1487548) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1658; hypothetical protein 1487548 4441801 SPD_1471 Streptococcus pneumoniae D39 hypothetical protein YP_816927.1 1487432 R 373153 CDS YP_816928.1 116515942 4441344 complement(1487996..1490788) 1 NC_008533.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase 1490788 ileS 4441344 ileS Streptococcus pneumoniae D39 isoleucyl-tRNA synthetase YP_816928.1 1487996 R 373153 CDS YP_816929.1 116516779 4442232 complement(1491041..1491157) 1 NC_008533.1 hypothetical protein 1491157 4442232 SPD_1473 Streptococcus pneumoniae D39 hypothetical protein YP_816929.1 1491041 R 373153 CDS YP_816930.1 116515933 4441335 complement(1491136..1491924) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1661; equivalent gene in S.pneumoniae R6 = spr1505; identified by match to protein family HMM PF05103; cell division protein DivIVA 1491924 divIVA 4441335 divIVA Streptococcus pneumoniae D39 cell division protein DivIVA YP_816930.1 1491136 R 373153 CDS YP_816931.1 116516882 4442125 complement(1491933..1492718) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1662; equivalent gene in S.pneumoniae R6 = spr1506; identified by match to protein family HMM PF01479; YlmH protein 1492718 ylmH 4442125 ylmH Streptococcus pneumoniae D39 YlmH protein YP_816931.1 1491933 R 373153 CDS YP_816932.1 116516690 4441364 complement(1492715..1492978) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1663; equivalent gene in S.pneumoniae R6 = spr1507; identified by match to protein family HMM PF02325; hypothetical protein 1492978 ylmG 4441364 ylmG Streptococcus pneumoniae D39 hypothetical protein YP_816932.1 1492715 R 373153 CDS YP_816933.1 116515526 4442890 complement(1492978..1493517) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1664; equivalent gene in S.pneumoniae R6 = spr1508; identified by match to protein family HMM PF04472; hypothetical protein 1493517 ylmF 4442890 ylmF Streptococcus pneumoniae D39 hypothetical protein YP_816933.1 1492978 R 373153 CDS YP_816934.1 116516370 4443032 complement(1493527..1494198) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1665; equivalent gene in S.pneumoniae R6 = spr1509; identified by match to protein family HMM TIGR00044; YlmE protein 1494198 ylmE 4443032 ylmE Streptococcus pneumoniae D39 YlmE protein YP_816934.1 1493527 R 373153 CDS YP_816935.1 116516283 4442611 complement(1494203..1495462) 1 NC_008533.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 1495462 ftsZ 4442611 ftsZ Streptococcus pneumoniae D39 cell division protein FtsZ YP_816935.1 1494203 R 373153 CDS YP_816936.1 116516996 4441979 complement(1495479..1496852) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1667; equivalent gene in S.pneumoniae R6 = spr1511; identified by match to protein family HMM PF02491; match to protein family HMM TIGR01174; cell division protein FtsA 1496852 ftsA 4441979 ftsA Streptococcus pneumoniae D39 cell division protein FtsA YP_816936.1 1495479 R 373153 CDS YP_816937.1 116515691 4442557 complement(1497071..1497775) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1668; equivalent gene in S.pneumoniae R6 = spr1512; identified by match to protein family HMM TIGR02206; hypothetical protein 1497775 4442557 SPD_1481 Streptococcus pneumoniae D39 hypothetical protein YP_816937.1 1497071 R 373153 CDS YP_816938.1 116516551 4441256 complement(1497866..1498477) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1669; equivalent gene in S.pneumoniae R6 = spr1513; identified by match to protein family HMM PF00293; MutT/nudix family protein 1498477 4441256 SPD_1482 Streptococcus pneumoniae D39 MutT/nudix family protein YP_816938.1 1497866 R 373153 CDS YP_816939.1 116515757 4442412 complement(1498464..1499837) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1670; equivalent gene in S.pneumoniae R6 = spr1514; identified by match to protein family HMM PF01225; match to protein family HMM PF02875; match to protein family HMM TIGR01143; UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6- diaminopimelate--D-alanyl-D-alanine ligase 1499837 murF 4442412 murF Streptococcus pneumoniae D39 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6- diaminopimelate--D-alanyl-D-alanine ligase YP_816939.1 1498464 R 373153 CDS YP_816940.1 116516832 4442150 complement(1499921..1500964) 1 NC_008533.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A 1500964 ddl 4442150 ddl Streptococcus pneumoniae D39 D-alanyl-alanine synthetase A YP_816940.1 1499921 R 373153 CDS YP_816941.1 116516007 4441569 complement(1501140..1501736) 1 NC_008533.1 involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 1501736 recR 4441569 recR Streptococcus pneumoniae D39 recombination protein RecR YP_816941.1 1501140 R 373153 CDS YP_816942.1 116517156 4441870 complement(1501747..1503804) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1673; equivalent gene in S.pneumoniae R6 = spr1517; identified by match to protein family HMM PF00905; match to protein family HMM PF03717; penicillin-binding protein 2B 1503804 penA 4441870 penA Streptococcus pneumoniae D39 penicillin-binding protein 2B YP_816942.1 1501747 R 373153 CDS YP_816943.1 116516240 4441520 1504004..1504855 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1674; equivalent gene in S.pneumoniae R6 = spr1518; identified by match to protein family HMM PF01380; match to protein family HMM PF01418; phosphosugar-binding transcriptional regulator 1504855 4441520 SPD_1487 Streptococcus pneumoniae D39 phosphosugar-binding transcriptional regulator YP_816943.1 1504004 D 373153 CDS YP_816944.1 116515474 4442644 complement(1504871..1505755) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1675; equivalent gene in S.pneumoniae R6 = spr1519; identified by match to protein family HMM PF00480; ROK family protein 1505755 4442644 SPD_1488 Streptococcus pneumoniae D39 ROK family protein YP_816944.1 1504871 R 373153 CDS YP_816945.1 116516552 4441257 complement(1505773..1506504) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1676; equivalent gene in S.pneumoniae R6 = spr1520; identified by match to protein family HMM PF00701; N-acetylneuraminate lyase 1506504 4441257 SPD_1489 Streptococcus pneumoniae D39 N-acetylneuraminate lyase YP_816945.1 1505773 R 373153 CDS YP_816946.1 116515320 4442663 complement(1506873..1507337) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1677; equivalent gene in S.pneumoniae R6 = spr1522; identified by match to protein family HMM PF04854; hypothetical protein 1507337 4442663 SPD_1490 Streptococcus pneumoniae D39 hypothetical protein YP_816946.1 1506873 R 373153 CDS YP_816947.1 116515978 4442429 complement(1507624..1507968) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1523; hypothetical protein 1507968 4442429 SPD_1491 Streptococcus pneumoniae D39 hypothetical protein YP_816947.1 1507624 R 373153 CDS YP_816948.1 116515454 4441178 complement(1508065..1508517) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1680; equivalent gene in S.pneumoniae R6 = spr1524; identified by match to protein family HMM PF04074; match to protein family HMM TIGR00022; hypothetical protein 1508517 4441178 SPD_1492 Streptococcus pneumoniae D39 hypothetical protein YP_816948.1 1508065 R 373153 CDS YP_816949.1 116516043 4441703 complement(1508790..1509629) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1681; equivalent gene in S.pneumoniae R6 = spr1525; identified by match to protein family HMM PF00528; sugar ABC transporter permease 1509629 4441703 SPD_1493 Streptococcus pneumoniae D39 sugar ABC transporter permease YP_816949.1 1508790 R 373153 CDS YP_816950.1 116516754 4442304 complement(1509645..1510532) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1682; equivalent gene in S.pneumoniae R6 = spr1526; identified by match to protein family HMM PF00528; sugar ABC transporter permease 1510532 4442304 SPD_1494 Streptococcus pneumoniae D39 sugar ABC transporter permease YP_816950.1 1509645 R 373153 CDS YP_816951.1 116515405 4442475 complement(1510763..1512091) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1683; equivalent gene in S.pneumoniae R6 = spr1527; identified by match to protein family HMM PF01547; sugar ABC transporter sugar-binding protein 1512091 4442475 SPD_1495 Streptococcus pneumoniae D39 sugar ABC transporter sugar-binding protein YP_816951.1 1510763 R 373153 CDS YP_816952.1 116516936 4442051 complement(1512216..1513733) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1684; equivalent gene in S.pneumoniae R6 = spr1528; identified by match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826; PTS system transporter subunit IIBC 1513733 4442051 SPD_1496 Streptococcus pneumoniae D39 PTS system transporter subunit IIBC YP_816952.1 1512216 R 373153 CDS YP_816953.1 116515887 4441385 complement(1513752..1514450) 1 NC_008533.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase 1514450 nanE-1 4441385 nanE-1 Streptococcus pneumoniae D39 N-acetylmannosamine-6-phosphate 2-epimerase YP_816953.1 1513752 R 373153 CDS YP_816954.1 116516108 4441633 complement(1514630..1515733) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1686; equivalent gene in S.pneumoniae R6 = spr1530; identified by match to protein family HMM PF01118; match to protein family HMM PF01408; match to protein family HMM PF02894; match to protein family HMM PF03447; oxidoreductase 1515733 4441633 SPD_1498 Streptococcus pneumoniae D39 oxidoreductase YP_816954.1 1514630 R 373153 CDS YP_816955.1 116516987 4442008 complement(1515745..1517838) 1 NC_008533.1 neuraminidase B; equivalent gene in S.pneumoniae TIGR4 = SP1687; equivalent gene in S.pneumoniae R6 = spr1531; identified by match to protein family HMM PF02012; match to protein family HMM PF02973; sialidase B 1517838 nanB 4442008 nanB Streptococcus pneumoniae D39 sialidase B YP_816955.1 1515745 R 373153 CDS YP_816956.1 116516337 4442820 complement(1517856..1518689) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1688; equivalent gene in S.pneumoniae R6 = spr1532; identified by match to protein family HMM PF00528; ABC transporter permease 1518689 4442820 SPD_1500 Streptococcus pneumoniae D39 ABC transporter permease YP_816956.1 1517856 R 373153 CDS YP_816957.1 116515660 4441243 complement(1518689..1519573) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1689; equivalent gene in S.pneumoniae R6 = spr1533; identified by match to protein family HMM PF00528; ABC transporter permease 1519573 4441243 SPD_1501 Streptococcus pneumoniae D39 ABC transporter permease YP_816957.1 1518689 R 373153 CDS YP_816958.1 116516571 4442092 complement(1519652..1520989) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1690; equivalent gene in S.pneumoniae R6 = spr1534; identified by match to protein family HMM PF01547; ABC transporter substrate-binding protein 1520989 4442092 SPD_1502 Streptococcus pneumoniae D39 ABC transporter substrate-binding protein YP_816958.1 1519652 R 373153 CDS YP_816959.1 116515591 4441211 complement(1521008..1521460) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1691; equivalent gene in S.pneumoniae R6 = spr1535; identified by match to protein family HMM PF04074; match to protein family HMM TIGR00022; hypothetical protein 1521460 4441211 SPD_1503 Streptococcus pneumoniae D39 hypothetical protein YP_816959.1 1521008 R 373153 CDS YP_816960.1 116517141 4442379 complement(1522475..1525468) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1536; identified by match to protein family HMM PF02012; match to protein family HMM PF02973; match to protein family HMM TIGR01167; sialidase A 1525468 nanA 4442379 nanA Streptococcus pneumoniae D39 sialidase A YP_816960.1 1522475 R 373153 CDS YP_816961.1 116515538 4442903 complement(1525825..1526052) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1694; equivalent gene in S.pneumoniae R6 = spr1537; hypothetical protein 1526052 4442903 SPD_1505 Streptococcus pneumoniae D39 hypothetical protein YP_816961.1 1525825 R 373153 CDS YP_816962.1 116516924 4442036 complement(1526947..1527927) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1695; equivalent gene in S.pneumoniae R6 = spr1538; identified by match to protein family HMM PF05448; acetyl xylan esterase 1527927 4442036 SPD_1506 Streptococcus pneumoniae D39 acetyl xylan esterase YP_816962.1 1526947 R 373153 CDS YP_816963.1 116516080 4442537 complement(1528243..1530258) 1 NC_008533.1 catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG 1530258 recG 4442537 recG Streptococcus pneumoniae D39 ATP-dependent DNA helicase RecG YP_816963.1 1528243 R 373153 CDS YP_816964.1 116515765 4441665 complement(1530277..1531380) 1 NC_008533.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase 1531380 alr 4441665 alr Streptococcus pneumoniae D39 alanine racemase YP_816964.1 1530277 R 373153 CDS YP_816965.1 116515875 4441372 complement(1531370..1531732) 1 NC_008533.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase 1531732 acpS 4441372 acpS Streptococcus pneumoniae D39 4'-phosphopantetheinyl transferase YP_816965.1 1531370 R 373153 CDS YP_816966.1 116516181 4441138 complement(1531777..1532808) 1 NC_008533.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 1532808 4441138 SPD_1510 Streptococcus pneumoniae D39 phospho-2-dehydro-3-deoxyheptonate aldolase YP_816966.1 1531777 R 373153 CDS YP_816967.1 116517167 4441842 complement(1532810..1533841) 1 NC_008533.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 1533841 4441842 SPD_1511 Streptococcus pneumoniae D39 phospho-2-dehydro-3-deoxyheptonate aldolase YP_816967.1 1532810 R 373153 CDS YP_816968.1 116515410 4442480 complement(1533922..1536435) 1 NC_008533.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 1536435 secA 4442480 secA Streptococcus pneumoniae D39 preprotein translocase subunit SecA YP_816968.1 1533922 R 373153 CDS YP_816969.1 116516316 4442799 complement(1536881..1537531) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1704; equivalent gene in S.pneumoniae R6 = spr1546; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1537531 4442799 SPD_1514 Streptococcus pneumoniae D39 ABC transporter ATP-binding protein YP_816969.1 1536881 R 373153 CDS YP_816970.1 116515682 4442548 complement(1537535..1538110) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1705; equivalent gene in S.pneumoniae R6 = spr1547; hypothetical protein 1538110 4442548 SPD_1515 Streptococcus pneumoniae D39 hypothetical protein YP_816970.1 1537535 R 373153 CDS YP_816971.1 116516608 4442385 complement(1538169..1538960) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1706; equivalent gene in S.pneumoniae R6 = spr1548; hypothetical protein 1538960 4442385 SPD_1516 Streptococcus pneumoniae D39 hypothetical protein YP_816971.1 1538169 R 373153 CDS YP_816972.1 116516969 4442922 complement(1538982..1539374) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1549; hypothetical protein 1539374 4442922 SPD_1517 Streptococcus pneumoniae D39 hypothetical protein YP_816972.1 1538982 R 373153 CDS YP_816973.1 116516974 4442927 1539701..1540552 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1550; identified by match to protein family HMM PF01381; match to protein family HMM TIGR01716; transcriptional activator, Rgg/GadR/MutR family protein 1540552 4442927 SPD_1518 Streptococcus pneumoniae D39 transcriptional activator, Rgg/GadR/MutR family protein YP_816973.1 1539701 D 373153 CDS YP_816974.1 116515879 4441376 complement(1541688..1542998) 1 NC_008533.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 1542998 engA 4441376 engA Streptococcus pneumoniae D39 GTP-binding protein EngA YP_816974.1 1541688 R 373153 CDS YP_816975.1 116517075 4441925 complement(1543012..1543725) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1710; equivalent gene in S.pneumoniae R6 = spr1554; identified by match to protein family HMM PF00881; nitroreductase family protein 1543725 4441925 SPD_1520 Streptococcus pneumoniae D39 nitroreductase family protein YP_816975.1 1543012 R 373153 CDS YP_816976.1 116516206 4441466 complement(1543722..1544618) 1 NC_008533.1 Primosomal protein that may act to load helicase DnaC during DNA replication; primosomal protein DnaI 1544618 dnaI 4441466 dnaI Streptococcus pneumoniae D39 primosomal protein DnaI YP_816976.1 1543722 R 373153 CDS YP_816977.1 116515470 4442640 complement(1544619..1545788) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1712; equivalent gene in S.pneumoniae R6 = spr1556; identified by match to protein family HMM PF07261; hypothetical protein 1545788 4442640 SPD_1522 Streptococcus pneumoniae D39 hypothetical protein YP_816977.1 1544619 R 373153 CDS YP_816978.1 116516730 4442319 complement(1545789..1546262) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1713; equivalent gene in S.pneumoniae R6 = spr1557; identified by match to protein family HMM PF03477; match to protein family HMM TIGR00244; transcriptional regulator NrdR 1546262 nrdR 4442319 nrdR Streptococcus pneumoniae D39 transcriptional regulator NrdR YP_816978.1 1545789 R 373153 CDS YP_816979.1 116516792 4442245 1546402..1546767 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1714; equivalent gene in S.pneumoniae R6 = spr1558; identified by match to protein family HMM PF00392; GntR family transcriptional regulator protein 1546767 4442245 SPD_1524 Streptococcus pneumoniae D39 GntR family transcriptional regulator protein YP_816979.1 1546402 D 373153 CDS YP_816980.1 116515972 4442423 1546772..1547467 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1715; equivalent gene in S.pneumoniae R6 = spr1559; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1547467 4442423 SPD_1525 Streptococcus pneumoniae D39 ABC transporter ATP-binding protein YP_816980.1 1546772 D 373153 CDS YP_816981.1 116515966 4441408 1547484..1548251 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1715; equivalent gene in S.pneumoniae R6 = spr1560; hypothetical protein 1548251 4441408 SPD_1526 Streptococcus pneumoniae D39 hypothetical protein YP_816981.1 1547484 D 373153 CDS YP_816982.1 116516998 4441981 complement(1548664..1549863) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1716; equivalent gene in S.pneumoniae R6 = spr1561; hypothetical protein 1549863 4441981 SPD_1527 Streptococcus pneumoniae D39 hypothetical protein YP_816982.1 1548664 R 373153 CDS YP_816983.1 116516180 4441137 complement(1549860..1550753) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1717; equivalent gene in S.pneumoniae R6 = spr1562; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1550753 4441137 SPD_1528 Streptococcus pneumoniae D39 ABC transporter ATP-binding protein YP_816983.1 1549860 R 373153 CDS YP_816984.1 116515885 4441382 1552062..1552679 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1720; equivalent gene in S.pneumoniae R6 = spr1564; hypothetical protein 1552679 4441382 SPD_1530 Streptococcus pneumoniae D39 hypothetical protein YP_816984.1 1552062 D 373153 CDS YP_816985.1 116516735 4442285 complement(1552999..1553886) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1721; equivalent gene in S.pneumoniae R6 = spr1565; identified by match to protein family HMM PF00480; fructokinase 1553886 scrK 4442285 scrK Streptococcus pneumoniae D39 fructokinase YP_816985.1 1552999 R 373153 CDS YP_816986.1 116517116 4441888 complement(1554035..1555918) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1722; equivalent gene in S.pneumoniae R6 = spr1566; identified by match to protein family HMM PF00358; match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826; match to protein family HMM TIGR00830; match to protein family HMM TIGR01996; PTS system IIABC components 1555918 4441888 SPD_1532 Streptococcus pneumoniae D39 PTS system IIABC components YP_816986.1 1554035 R 373153 CDS YP_816987.1 116515797 4441562 complement(1556045..1556242) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1723; hypothetical protein 1556242 4441562 SPD_1533 Streptococcus pneumoniae D39 hypothetical protein YP_816987.1 1556045 R 373153 CDS YP_816988.1 116516412 4442978 1556295..1557749 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1724; equivalent gene in S.pneumoniae R6 = spr1568; identified by match to protein family HMM PF00251; match to protein family HMM TIGR01322; sucrose-6-phosphate hydrolase 1557749 scrB 4442978 scrB Streptococcus pneumoniae D39 sucrose-6-phosphate hydrolase YP_816988.1 1556295 D 373153 CDS YP_816989.1 116516061 4442770 1557730..1558695 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1725; equivalent gene in S.pneumoniae R6 = spr1569; identified by match to protein family HMM PF00356; match to protein family HMM PF00532; sucrose operon repressor 1558695 scrR 4442770 scrR Streptococcus pneumoniae D39 sucrose operon repressor YP_816989.1 1557730 D 373153 CDS YP_816990.1 116516718 4442305 complement(1558730..1560004) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1726; equivalent gene in S.pneumoniae R6 = spr1570; identified by match to protein family HMM TIGR00532; hydroxymethylglutaryl-CoA reductase, degradative 1560004 4442305 SPD_1536 Streptococcus pneumoniae D39 hydroxymethylglutaryl-CoA reductase, degradative YP_816990.1 1558730 R 373153 CDS YP_816991.1 116515383 4441619 complement(1560004..1561200) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1727; equivalent gene in S.pneumoniae R6 = spr1571; identified by match to protein family HMM PF01154; match to protein family HMM TIGR01835; hydroxymethylglutaryl-CoA synthase 1561200 mvaS 4441619 mvaS Streptococcus pneumoniae D39 hydroxymethylglutaryl-CoA synthase YP_816991.1 1560004 R 373153 CDS YP_816992.1 116515856 4441548 complement(1561307..1561594) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1728; equivalent gene in S.pneumoniae R6 = spr1572; hypothetical protein 1561594 4441548 SPD_1538 Streptococcus pneumoniae D39 hypothetical protein YP_816992.1 1561307 R 373153 CDS YP_816993.1 116516534 4441037 complement(1562311..1562760) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1730; equivalent gene in S.pneumoniae R6 = spr1575; hypothetical protein 1562760 4441037 SPD_1540 Streptococcus pneumoniae D39 hypothetical protein YP_816993.1 1562311 R 373153 CDS YP_816994.1 116516263 4441773 complement(1562762..1563520) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1731; equivalent gene in S.pneumoniae R6 = spr1576; identified by match to protein family HMM PF06738; hypothetical protein 1563520 4441773 SPD_1541 Streptococcus pneumoniae D39 hypothetical protein YP_816994.1 1562762 R 373153 CDS YP_816995.1 116517182 4441819 complement(1563635..1565614) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1732; equivalent gene in S.pneumoniae R6 = spr1577; identified by match to protein family HMM PF00069; match to protein family HMM PF01163; match to protein family HMM PF03793; serine/threonine protein kinase 1565614 4441819 SPD_1542 Streptococcus pneumoniae D39 serine/threonine protein kinase YP_816995.1 1563635 R 373153 CDS YP_816996.1 116515932 4441334 complement(1565611..1566351) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1733; equivalent gene in S.pneumoniae R6 = spr1578; identified by match to protein family HMM PF00481; phosphatase 1566351 4441334 SPD_1543 Streptococcus pneumoniae D39 phosphatase YP_816996.1 1565611 R 373153 CDS YP_816997.1 116517030 4442344 complement(1566366..1567679) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1734; equivalent gene in S.pneumoniae R6 = spr1579; identified by match to protein family HMM PF01029; match to protein family HMM PF01189; match to protein family HMM TIGR00563; ribosomal RNA small subunit methyltransferase B 1567679 sun 4442344 sun Streptococcus pneumoniae D39 ribosomal RNA small subunit methyltransferase B YP_816997.1 1566366 R 373153 CDS YP_816998.1 116515769 4441669 complement(1567672..1568607) 1 NC_008533.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase 1568607 fmt 4441669 fmt Streptococcus pneumoniae D39 methionyl-tRNA formyltransferase YP_816998.1 1567672 R 373153 CDS YP_816999.1 116516961 4442914 complement(1568620..1571016) 1 NC_008533.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA 1571016 priA 4442914 priA Streptococcus pneumoniae D39 primosome assembly protein PriA YP_816999.1 1568620 R 373153 CDS YP_817000.1 116515579 4441196 complement(1571082..1571396) 1 NC_008533.1 Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 1571396 4441196 SPD_1547 Streptococcus pneumoniae D39 DNA-directed RNA polymerase subunit omega YP_817000.1 1571082 R 373153 CDS YP_817001.1 116516658 4443062 complement(1571421..1572047) 1 NC_008533.1 Essential for recycling GMP and indirectly, cGMP; guanylate kinase 1572047 gmk 4443062 gmk Streptococcus pneumoniae D39 guanylate kinase YP_817001.1 1571421 R 373153 CDS YP_817002.1 116516869 4442112 complement(1572177..1573790) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1739; equivalent gene in S.pneumoniae R6 = spr1584; identified by match to protein family HMM PF00013; match to protein family HMM PF01966; match to protein family HMM TIGR00277; hypothetical protein 1573790 4442112 SPD_1549 Streptococcus pneumoniae D39 hypothetical protein YP_817002.1 1572177 R 373153 CDS YP_817003.1 116515838 4441130 complement(1573981..1574235) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1740; equivalent gene in S.pneumoniae R6 = spr1585; identified by match to protein family HMM PF06769; match to protein family HMM TIGR02116; hypothetical protein 1574235 4441130 SPD_1550 Streptococcus pneumoniae D39 hypothetical protein YP_817003.1 1573981 R 373153 CDS YP_817004.1 116516949 4442026 complement(1574239..1574499) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1741; equivalent gene in S.pneumoniae R6 = spr1586; identified by match to protein family HMM PF02604; match to protein family HMM TIGR01552; hypothetical protein 1574499 4442026 SPD_1551 Streptococcus pneumoniae D39 hypothetical protein YP_817004.1 1574239 R 373153 CDS YP_817005.1 116516082 4442676 complement(1574731..1575828) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1742; equivalent gene in S.pneumoniae R6 = spr1587; identified by match to protein family HMM PF05636; hypothetical protein 1575828 4442676 SPD_1552 Streptococcus pneumoniae D39 hypothetical protein YP_817005.1 1574731 R 373153 CDS YP_817006.1 116517052 4441940 complement(1575838..1576584) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1743; equivalent gene in S.pneumoniae R6 = spr1588; hypothetical protein 1576584 4441940 SPD_1553 Streptococcus pneumoniae D39 hypothetical protein YP_817006.1 1575838 R 373153 CDS YP_817007.1 116515553 4442727 complement(1576687..1577040) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1744; equivalent gene in S.pneumoniae R6 = spr1589; identified by match to protein family HMM PF02410; match to protein family HMM TIGR00090; iojap-like protein 1577040 4442727 SPD_1554 Streptococcus pneumoniae D39 iojap-like protein YP_817007.1 1576687 R 373153 CDS YP_817008.1 116516727 4442316 complement(1577053..1577553) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1745; equivalent gene in S.pneumoniae R6 = spr1590; identified by match to protein family HMM PF00857; isochorismatase family protein 1577553 4442316 SPD_1555 Streptococcus pneumoniae D39 isochorismatase family protein YP_817008.1 1577053 R 373153 CDS YP_817009.1 116515369 4441169 complement(1577554..1578147) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1746; equivalent gene in S.pneumoniae R6 = spr1591; identified by match to protein family HMM PF01966; match to protein family HMM TIGR00277; match to protein family HMM TIGR00488; hypothetical protein 1578147 4441169 SPD_1556 Streptococcus pneumoniae D39 hypothetical protein YP_817009.1 1577554 R 373153 CDS YP_817010.1 116515834 4441125 complement(1578147..1578776) 1 NC_008533.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase 1578776 nadD 4441125 nadD Streptococcus pneumoniae D39 nicotinic acid mononucleotide adenylyltransferase YP_817010.1 1578147 R 373153 CDS YP_817011.1 116515641 4441321 complement(1578828..1579139) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1748; equivalent gene in S.pneumoniae R6 = spr1593; identified by match to protein family HMM PF01985; match to protein family HMM TIGR00253; hypothetical protein 1579139 4441321 SPD_1558 Streptococcus pneumoniae D39 hypothetical protein YP_817011.1 1578828 R 373153 CDS YP_817012.1 116516270 4442598 complement(1579354..1580460) 1 NC_008533.1 in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis; GTP-binding protein YqeH 1580460 4442598 SPD_1559 Streptococcus pneumoniae D39 GTP-binding protein YqeH YP_817012.1 1579354 R 373153 CDS YP_817013.1 116517207 4441805 complement(1580463..1580990) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1750; equivalent gene in S.pneumoniae R6 = spr1595; identified by match to protein family HMM TIGR01662; match to protein family HMM TIGR01668; hypothetical protein 1580990 4441805 SPD_1560 Streptococcus pneumoniae D39 hypothetical protein YP_817013.1 1580463 R 373153 CDS YP_817014.1 116516142 4442504 complement(1581005..1581901) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1751; equivalent gene in S.pneumoniae R6 = spr1596; identified by match to protein family HMM PF01544; magnesium transporter CorA family protein 1581901 4442504 SPD_1561 Streptococcus pneumoniae D39 magnesium transporter CorA family protein YP_817014.1 1581005 R 373153 CDS YP_817015.1 116516950 4442027 complement(1581958..1582554) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1752; equivalent gene in S.pneumoniae R6 = spr1597; identified by match to protein family HMM PF00924; small conductance mechanosensitive ion channel (MscS) family protein 1582554 4442027 SPD_1562 Streptococcus pneumoniae D39 small conductance mechanosensitive ion channel (MscS) family protein YP_817015.1 1581958 R 373153 CDS YP_817016.1 116516711 4442337 1582907..1583866 1 NC_008533.1 involved in the import of serine and threonine coupled with the import of sodium; serine/threonine transporter SstT 1583866 4442337 SPD_1563 Streptococcus pneumoniae D39 serine/threonine transporter SstT YP_817016.1 1582907 D 373153 CDS YP_817017.1 116517163 4441877 1583934..1584887 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1754; equivalent gene in S.pneumoniae R6 = spr1599; identified by match to protein family HMM PF06081; hypothetical protein 1584887 4441877 SPD_1564 Streptococcus pneumoniae D39 hypothetical protein YP_817017.1 1583934 D 373153 CDS YP_817018.1 116516515 4443066 1585031..1585411 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1774; equivalent gene in S.pneumoniae R6 = spr1600; identified by match to protein family HMM PF01047; transcriptional regulator 1585411 4443066 SPD_1565 Streptococcus pneumoniae D39 transcriptional regulator YP_817018.1 1585031 D 373153 CDS YP_817019.1 116515687 4442553 1585429..1585731 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1775; equivalent gene in S.pneumoniae R6 = spr1601; hypothetical protein 1585731 4442553 SPD_1566 Streptococcus pneumoniae D39 hypothetical protein YP_817019.1 1585429 D 373153 CDS YP_817020.1 116516780 4442233 1585748..1586062 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1776; equivalent gene in S.pneumoniae R6 = spr1602; identified by match to protein family HMM PF00085; match to protein family HMM TIGR01068; thioredoxin 1586062 trx 4442233 trx Streptococcus pneumoniae D39 thioredoxin YP_817020.1 1585748 D 373153 CDS YP_817021.1 116515904 4442784 1586556..1586900 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1777; equivalent gene in S.pneumoniae R6 = spr1603; identified by match to protein family HMM PF01227; GTP cyclohydrolase 1586900 4442784 SPD_1568 Streptococcus pneumoniae D39 GTP cyclohydrolase YP_817021.1 1586556 D 373153 CDS YP_817022.1 116515733 4441021 complement(1587380..1588048) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1778; equivalent gene in S.pneumoniae R6 = spr1604; identified by match to protein family HMM PF00230; aquaporin 1588048 4441021 SPD_1569 Streptococcus pneumoniae D39 aquaporin YP_817022.1 1587380 R 373153 CDS YP_817023.1 116515449 4441173 complement(1588159..1588713) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1779; equivalent gene in S.pneumoniae R6 = spr1605; hypothetical protein 1588713 4441173 SPD_1570 Streptococcus pneumoniae D39 hypothetical protein YP_817023.1 1588159 R 373153 CDS YP_817024.1 116516584 4442108 complement(1588959..1590755) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1780; equivalent gene in S.pneumoniae R6 = spr1606; identified by match to protein family HMM PF01432; match to protein family HMM TIGR00181; oligoendopeptidase F 1590755 4442108 SPD_1571 Streptococcus pneumoniae D39 oligoendopeptidase F YP_817024.1 1588959 R 373153 CDS YP_817025.1 116515693 4441433 complement(1590766..1591509) 1 NC_008533.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 1591509 4441433 SPD_1572 Streptococcus pneumoniae D39 16S ribosomal RNA methyltransferase RsmE YP_817025.1 1590766 R 373153 CDS YP_817026.1 116516647 4443051 complement(1591511..1592461) 1 NC_008533.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; 50S ribosomal protein L11 methyltransferase 1592461 prmA 4443051 prmA Streptococcus pneumoniae D39 50S ribosomal protein L11 methyltransferase YP_817026.1 1591511 R 373153 CDS YP_817027.1 116515601 4442740 complement(1592599..1593027) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1609; identified by match to protein family HMM PF00293; MutT/nudix family protein 1593027 4442740 SPD_1574 Streptococcus pneumoniae D39 MutT/nudix family protein YP_817027.1 1592599 R 373153 CDS YP_817028.1 116517094 4441905 complement(1592993..1594096) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1784; equivalent gene in S.pneumoniae R6 = spr1610; identified by match to protein family HMM PF02163; hypothetical protein 1594096 4441905 SPD_1575 Streptococcus pneumoniae D39 hypothetical protein YP_817028.1 1592993 R 373153 CDS YP_817029.1 116515833 4441124 complement(1594115..1594585) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1785; equivalent gene in S.pneumoniae R6 = spr1611; hypothetical protein 1594585 4441124 SPD_1576 Streptococcus pneumoniae D39 hypothetical protein YP_817029.1 1594115 R 373153 CDS YP_817030.1 116515428 4442498 complement(1594876..1595328) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1786; equivalent gene in S.pneumoniae R6 = spr1612; identified by match to protein family HMM PF03681; hypothetical protein 1595328 4442498 SPD_1577 Streptococcus pneumoniae D39 hypothetical protein YP_817030.1 1594876 R 373153 CDS YP_817031.1 116516279 4442607 complement(1595681..1595860) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1614; hypothetical protein 1595860 4442607 SPD_1578 Streptococcus pneumoniae D39 hypothetical protein YP_817031.1 1595681 R 373153 CDS YP_817032.1 116515699 4441441 complement(1596025..1596264) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1789; equivalent gene in S.pneumoniae R6 = spr1615; hypothetical protein 1596264 4441441 SPD_1579 Streptococcus pneumoniae D39 hypothetical protein YP_817032.1 1596025 R 373153 CDS YP_817033.1 116516731 4442320 1596534..1597805 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1790; equivalent gene in S.pneumoniae R6 = spr1616; identified by match to protein family HMM PF00004; recombination factor protein RarA 1597805 4442320 SPD_1580 Streptococcus pneumoniae D39 recombination factor protein RarA YP_817033.1 1596534 D 373153 CDS YP_817034.1 116517206 4441804 complement(1598352..1599671) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1795; equivalent gene in S.pneumoniae R6 = spr1617; identified by match to protein family HMM PF00251; match to protein family HMM TIGR01322; sucrose-6-phosphate hydrolase 1599671 4441804 SPD_1582 Streptococcus pneumoniae D39 sucrose-6-phosphate hydrolase YP_817034.1 1598352 R 373153 CDS YP_817035.1 116516106 4441631 complement(1599681..1600526) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1618; identified by match to protein family HMM PF00528; ABC transporter permease 1600526 4441631 SPD_1583 Streptococcus pneumoniae D39 ABC transporter permease YP_817035.1 1599681 R 373153 CDS YP_817036.1 116515702 4441444 complement(1600528..1601430) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1619; identified by match to protein family HMM PF00528; ABC transporter permease 1601430 4441444 SPD_1584 Streptococcus pneumoniae D39 ABC transporter permease YP_817036.1 1600528 R 373153 CDS YP_817037.1 116516945 4442021 complement(1601526..1602836) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1620; identified by match to protein family HMM PF01547; sugar ABC transporter substrate-binding protein 1602836 4442021 SPD_1585 Streptococcus pneumoniae D39 sugar ABC transporter substrate-binding protein YP_817037.1 1601526 R 373153 CDS YP_817038.1 116515545 4442719 complement(1602963..1603958) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1621; identified by match to protein family HMM PF00356; match to protein family HMM PF00532; LacI family transcriptional regulator 1603958 4442719 SPD_1586 Streptococcus pneumoniae D39 LacI family transcriptional regulator YP_817038.1 1602963 R 373153 CDS YP_817039.1 116516300 4442589 complement(1604320..1605801) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1800; equivalent gene in S.pneumoniae R6 = spr1622; identified by match to protein family HMM PF05043; transcriptional activator 1605801 4442589 SPD_1587 Streptococcus pneumoniae D39 transcriptional activator YP_817039.1 1604320 R 373153 CDS YP_817040.1 116516127 4442215 1606491..1607057 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1802; equivalent gene in S.pneumoniae R6 = spr1623; hypothetical protein 1607057 4442215 SPD_1588 Streptococcus pneumoniae D39 hypothetical protein YP_817040.1 1606491 D 373153 CDS YP_817041.1 116515552 4442726 1607069..1607239 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1803; equivalent gene in S.pneumoniae R6 = spr1624; hypothetical protein 1607239 4442726 SPD_1589 Streptococcus pneumoniae D39 hypothetical protein YP_817041.1 1607069 D 373153 CDS YP_817042.1 116515908 4442788 1607278..1607886 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1804; equivalent gene in S.pneumoniae R6 = spr1625; identified by match to protein family HMM PF03780; general stress protein 24 1607886 4442788 SPD_1590 Streptococcus pneumoniae D39 general stress protein 24 YP_817042.1 1607278 D 373153 CDS YP_817043.1 116515903 4442783 1607917..1608120 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1805; equivalent gene in S.pneumoniae R6 = spr1626; identified by match to protein family HMM PF05532; hypothetical protein 1608120 4442783 SPD_1591 Streptococcus pneumoniae D39 hypothetical protein YP_817043.1 1607917 D 373153 CDS YP_817044.1 116516977 4441997 complement(1608647..1609093) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1807; equivalent gene in S.pneumoniae R6 = spr1627; identified by match to protein family HMM PF00583; GNAT family acetyltransferase 1609093 4441997 SPD_1592 Streptococcus pneumoniae D39 GNAT family acetyltransferase YP_817044.1 1608647 R 373153 CDS YP_817045.1 116516208 4441468 1609163..1609822 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1808; equivalent gene in S.pneumoniae R6 = spr1628; identified by match to protein family HMM PF01478; match to protein family HMM PF06750; type IV prepilin peptidase 1609822 4441468 SPD_1593 Streptococcus pneumoniae D39 type IV prepilin peptidase YP_817045.1 1609163 D 373153 CDS YP_817046.1 116516126 4442214 complement(1609874..1611025) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1809; equivalent gene in S.pneumoniae R6 = spr1629; identified by match to protein family HMM PF01381; match to protein family HMM PF06114; transcriptional regulator 1611025 4442214 SPD_1594 Streptococcus pneumoniae D39 transcriptional regulator YP_817046.1 1609874 R 373153 CDS YP_817047.1 116517126 4442364 complement(1611040..1611771) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1810; equivalent gene in S.pneumoniae R6 = spr1630; hypothetical protein 1611771 4442364 SPD_1595 Streptococcus pneumoniae D39 hypothetical protein YP_817047.1 1611040 R 373153 CDS YP_817048.1 116515328 4442671 complement(1612073..1612849) 1 NC_008533.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 1612849 trpA 4442671 trpA Streptococcus pneumoniae D39 tryptophan synthase subunit alpha YP_817048.1 1612073 R 373153 CDS YP_817049.1 116516622 4442400 complement(1612842..1614065) 1 NC_008533.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 1614065 trpB 4442400 trpB Streptococcus pneumoniae D39 tryptophan synthase subunit beta YP_817049.1 1612842 R 373153 CDS YP_817050.1 116515967 4441409 complement(1614043..1614642) 1 NC_008533.1 catalyzes the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)-anthranilate in tryptophan biosynthesis; N-(5'-phosphoribosyl)anthranilate isomerase 1614642 trpF 4441409 trpF Streptococcus pneumoniae D39 N-(5'-phosphoribosyl)anthranilate isomerase YP_817050.1 1614043 R 373153 CDS YP_817051.1 116516838 4442158 complement(1614629..1615396) 1 NC_008533.1 involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water; indole-3-glycerol-phosphate synthase 1615396 trpC 4442158 trpC Streptococcus pneumoniae D39 indole-3-glycerol-phosphate synthase YP_817051.1 1614629 R 373153 CDS YP_817052.1 116516280 4442608 complement(1615393..1616397) 1 NC_008533.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate; anthranilate phosphoribosyltransferase 1616397 trpD 4442608 trpD Streptococcus pneumoniae D39 anthranilate phosphoribosyltransferase YP_817052.1 1615393 R 373153 CDS YP_817053.1 116516075 4442532 complement(1616408..1616974) 1 NC_008533.1 TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity; anthranilate synthase component II 1616974 trpG 4442532 trpG Streptococcus pneumoniae D39 anthranilate synthase component II YP_817053.1 1616408 R 373153 CDS YP_817054.1 116516925 4442037 complement(1616971..1618332) 1 NC_008533.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I 1618332 trpE 4442037 trpE Streptococcus pneumoniae D39 anthranilate synthase component I YP_817054.1 1616971 R 373153 CDS YP_817055.1 116515981 4442432 complement(1618467..1618622) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1638; hypothetical protein 1618622 4442432 SPD_1603 Streptococcus pneumoniae D39 hypothetical protein YP_817055.1 1618467 R 373153 CDS YP_817056.1 116515832 4441123 complement(1618626..1618745) 1 NC_008533.1 hypothetical protein 1618745 4441123 SPD_1604 Streptococcus pneumoniae D39 hypothetical protein YP_817056.1 1618626 R 373153 CDS YP_817057.1 116516729 4442318 complement(1619519..1620520) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1821; equivalent gene in S.pneumoniae R6 = spr1639; identified by match to protein family HMM PF00356; match to protein family HMM PF00532; LacI family transcriptional regulator 1620520 4442318 SPD_1605 Streptococcus pneumoniae D39 LacI family transcriptional regulator YP_817057.1 1619519 R 373153 CDS YP_817058.1 116515634 4442714 complement(1621092..1621802) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1823; equivalent gene in S.pneumoniae R6 = spr1641; identified by match to protein family HMM PF02308; MgtC/SapB family protein 1621802 4442714 SPD_1606 Streptococcus pneumoniae D39 MgtC/SapB family protein YP_817058.1 1621092 R 373153 CDS YP_817059.1 116516480 4443009 complement(1621805..1623496) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1824; equivalent gene in S.pneumoniae R6 = spr1643; identified by match to protein family HMM PF00528; ABC transporter permease 1623496 4443009 SPD_1607 Streptococcus pneumoniae D39 ABC transporter permease YP_817059.1 1621805 R 373153 CDS YP_817060.1 116516345 4442830 complement(1623508..1624518) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1825; equivalent gene in S.pneumoniae R6 = spr1644; identified by match to protein family HMM PF00005; match to protein family HMM PF03459; ABC transporter ATP-binding protein 1624518 4442830 SPD_1608 Streptococcus pneumoniae D39 ABC transporter ATP-binding protein YP_817060.1 1623508 R 373153 CDS YP_817061.1 116515427 4442497 complement(1624621..1625688) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1826; equivalent gene in S.pneumoniae R6 = spr1645; ABC transporter substrate-binding protein 1625688 4442497 SPD_1609 Streptococcus pneumoniae D39 ABC transporter substrate-binding protein YP_817061.1 1624621 R 373153 CDS YP_817062.1 116516088 4442682 complement(1625713..1626372) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1827; equivalent gene in S.pneumoniae R6 = spr1646; hypothetical protein 1626372 4442682 SPD_1610 Streptococcus pneumoniae D39 hypothetical protein YP_817062.1 1625713 R 373153 CDS YP_817063.1 116517152 4441866 complement(1626500..1626613) 1 NC_008533.1 hypothetical protein 1626613 4441866 SPD_1611 Streptococcus pneumoniae D39 hypothetical protein YP_817063.1 1626500 R 373153 CDS YP_817064.1 116515568 4442878 complement(1626582..1627562) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1828; equivalent gene in S.pneumoniae R6 = spr1647; identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF07993; match to protein family HMM TIGR01179; UDP-glucose 4-epimerase 1627562 galE-2 4442878 galE-2 Streptococcus pneumoniae D39 UDP-glucose 4-epimerase YP_817064.1 1626582 R 373153 CDS YP_817065.1 116516923 4442034 complement(1627575..1629050) 1 NC_008533.1 catalyzes the formation of alpha-D-glucose 1-phosphate and UDP-galactose from UDP-glucose and alpha-D-galactose 1-phosphate in galactose metabolism; galactose-1-phosphate uridylyltransferase 1629050 galT-1 4442034 galT-1 Streptococcus pneumoniae D39 galactose-1-phosphate uridylyltransferase YP_817065.1 1627575 R 373153 CDS YP_817066.1 116516347 4442949 complement(1629063..1629704) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1830; equivalent gene in S.pneumoniae R6 = spr1649; phosphate transport system regulatory protein PhoU 1629704 4442949 SPD_1614 Streptococcus pneumoniae D39 phosphate transport system regulatory protein PhoU YP_817066.1 1629063 R 373153 CDS YP_817067.1 116515595 4441215 complement(1629762..1630256) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1831; equivalent gene in S.pneumoniae R6 = spr1650; hypothetical protein 1630256 4441215 SPD_1615 Streptococcus pneumoniae D39 hypothetical protein YP_817067.1 1629762 R 373153 CDS YP_817068.1 116516072 4442528 complement(1630317..1630613) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1832; equivalent gene in S.pneumoniae R6 = spr1651; hypothetical protein 1630613 4442528 SPD_1616 Streptococcus pneumoniae D39 hypothetical protein YP_817068.1 1630317 R 373153 CDS YP_817069.1 116515361 4441161 complement(1630597..1632723) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1833; equivalent gene in S.pneumoniae R6 = spr1652; identified by match to protein family HMM PF04650; match to protein family HMM TIGR01168; cell wall surface anchor family protein 1632723 4441161 SPD_1617 Streptococcus pneumoniae D39 cell wall surface anchor family protein YP_817069.1 1630597 R 373153 CDS YP_817070.1 116517214 4441812 1633669..1633845 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1836; equivalent gene in S.pneumoniae R6 = spr1653; hypothetical protein 1633845 4441812 SPD_1618 Streptococcus pneumoniae D39 hypothetical protein YP_817070.1 1633669 D 373153 CDS YP_817071.1 116516120 4441645 complement(1633887..1635113) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1837; equivalent gene in S.pneumoniae R6 = spr1654; identified by match to protein family HMM PF01041; capsular polysaccharide biosynthesis protein 1635113 4441645 SPD_1619 Streptococcus pneumoniae D39 capsular polysaccharide biosynthesis protein YP_817071.1 1633887 R 373153 CDS YP_817072.1 116516993 4441975 complement(1635156..1635848) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1838; equivalent gene in S.pneumoniae R6 = spr1655; identified by match to protein family HMM PF02397; glycosyl transferase family protein 1635848 4441975 SPD_1620 Streptococcus pneumoniae D39 glycosyl transferase family protein YP_817072.1 1635156 R 373153 CDS YP_817073.1 116516065 4442520 complement(1636021..1637772) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1839; equivalent gene in S.pneumoniae R6 = spr1656; identified by match to protein family HMM PF00005; match to protein family HMM PF00664; ABC transporter ATP-binding protein/permease 1637772 4442520 SPD_1621 Streptococcus pneumoniae D39 ABC transporter ATP-binding protein/permease YP_817073.1 1636021 R 373153 CDS YP_817074.1 116515751 4442406 complement(1637762..1639507) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1840; equivalent gene in S.pneumoniae R6 = spr1657; identified by match to protein family HMM PF00005; match to protein family HMM PF00664; ABC transporter ATP-binding protein/permease 1639507 4442406 SPD_1622 Streptococcus pneumoniae D39 ABC transporter ATP-binding protein/permease YP_817074.1 1637762 R 373153 CDS YP_817075.1 116515837 4441129 complement(1639635..1640165) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1841; equivalent gene in S.pneumoniae R6 = spr1658; identified by match to protein family HMM PF04239; hypothetical protein 1640165 4441129 SPD_1623 Streptococcus pneumoniae D39 hypothetical protein YP_817075.1 1639635 R 373153 CDS YP_817076.1 116515487 4441297 complement(1640162..1640431) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1842; equivalent gene in S.pneumoniae R6 = spr1659; hypothetical protein 1640431 4441297 SPD_1624 Streptococcus pneumoniae D39 hypothetical protein YP_817076.1 1640162 R 373153 CDS YP_817077.1 116516579 4442100 complement(1640391..1640618) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1844; hypothetical protein 1640618 4442100 SPD_1625 Streptococcus pneumoniae D39 hypothetical protein YP_817077.1 1640391 R 373153 CDS YP_817078.1 116516049 4442758 1640752..1641579 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1845; equivalent gene in S.pneumoniae R6 = spr1660; identified by match to protein family HMM PF03372; match to protein family HMM TIGR00195; match to protein family HMM TIGR00633; exodeoxyribonuclease III 1641579 xth 4442758 xth Streptococcus pneumoniae D39 exodeoxyribonuclease III YP_817078.1 1640752 D 373153 CDS YP_817079.1 116515812 4442859 1642851..1643432 1 NC_008533.1 Catalyzes the transfer of the phosphoribosyl moiety from 5-phospho--D-ribosyl-1-pyrophosphate (PRib-PP) to the 6-oxo-guanine and -xanthine; xanthine phosphoribosyltransferase 1643432 xpt 4442859 xpt Streptococcus pneumoniae D39 xanthine phosphoribosyltransferase YP_817079.1 1642851 D 373153 CDS YP_817080.1 116516978 4441998 1643432..1644694 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1848; equivalent gene in S.pneumoniae R6 = spr1663; identified by match to protein family HMM PF00860; match to protein family HMM PF00916; match to protein family HMM TIGR00801; xanthine permease 1644694 pbuX 4441998 pbuX Streptococcus pneumoniae D39 xanthine permease YP_817080.1 1643432 D 373153 CDS YP_817081.1 116515864 4441100 complement(1644745..1645206) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1849; equivalent gene in S.pneumoniae R6 = spr1664; hypothetical protein 1645206 4441100 SPD_1630 Streptococcus pneumoniae D39 hypothetical protein YP_817081.1 1644745 R 373153 CDS YP_817082.1 116516583 4442106 complement(1645203..1645967) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1850; equivalent gene in S.pneumoniae R6 = spr1665; identified by match to protein family HMM PF06044; Dam-replacing family protein 1645967 4442106 SPD_1631 Streptococcus pneumoniae D39 Dam-replacing family protein YP_817082.1 1645203 R 373153 CDS YP_817083.1 116516006 4441510 complement(1646148..1646552) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1851; equivalent gene in S.pneumoniae R6 = spr1666; identified by match to protein family HMM PF03061; match to protein family HMM TIGR00369; hypothetical protein 1646552 4441510 SPD_1632 Streptococcus pneumoniae D39 hypothetical protein YP_817083.1 1646148 R 373153 CDS YP_817084.1 116517165 4441840 complement(1646622..1648103) 1 NC_008533.1 catalyzes the formation of alpha-D-glucose 1-phosphate and UDP-galactose from UDP-glucose and alpha-D-galactose 1-phosphate in galactose metabolism; galactose-1-phosphate uridylyltransferase 1648103 galT-2 4441840 galT-2 Streptococcus pneumoniae D39 galactose-1-phosphate uridylyltransferase YP_817084.1 1646622 R 373153 CDS YP_817085.1 116516140 4442502 complement(1648122..1649300) 1 NC_008533.1 catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase 1649300 galK 4442502 galK Streptococcus pneumoniae D39 galactokinase YP_817085.1 1648122 R 373153 CDS YP_817086.1 116515548 4442722 1649464..1650471 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1854; equivalent gene in S.pneumoniae R6 = spr1669; identified by match to protein family HMM PF00356; match to protein family HMM PF00532; galactose operon repressor 1650471 galR 4442722 galR Streptococcus pneumoniae D39 galactose operon repressor YP_817086.1 1649464 D 373153 CDS YP_817087.1 116516381 4443044 complement(1650517..1651554) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1855; equivalent gene in S.pneumoniae R6 = spr1670; identified by match to protein family HMM PF00107; zinc-containing alcohol dehydrogenase 1651554 4443044 SPD_1636 Streptococcus pneumoniae D39 zinc-containing alcohol dehydrogenase YP_817087.1 1650517 R 373153 CDS YP_817088.1 116515738 4441026 complement(1651555..1651908) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1856; equivalent gene in S.pneumoniae R6 = spr1671; identified by match to protein family HMM PF00376; transcriptional regulator, MerR family protein 1651908 4441026 SPD_1637 Streptococcus pneumoniae D39 transcriptional regulator, MerR family protein YP_817088.1 1651555 R 373153 CDS YP_817089.1 116516957 4442910 complement(1652152..1653042) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1857; equivalent gene in S.pneumoniae R6 = spr1672; identified by match to protein family HMM PF01545; match to protein family HMM TIGR01297; cation efflux system protein 1653042 4442910 SPD_1638 Streptococcus pneumoniae D39 cation efflux system protein YP_817089.1 1652152 R 373153 CDS YP_817090.1 116516665 4442444 1653175..1653711 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1858; equivalent gene in S.pneumoniae R6 = spr1673; identified by match to protein family HMM PF00440; transcriptional regulator, TetR family protein 1653711 4442444 SPD_1639 Streptococcus pneumoniae D39 transcriptional regulator, TetR family protein YP_817090.1 1653175 D 373153 CDS YP_817091.1 116515309 4441191 complement(1653878..1654684) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1859; equivalent gene in S.pneumoniae R6 = spr1674; identified by match to protein family HMM PF04973; match to protein family HMM TIGR01528; nicotinamide mononucleotide transporter PnuC 1654684 pnuC 4441191 pnuC Streptococcus pneumoniae D39 nicotinamide mononucleotide transporter PnuC YP_817091.1 1653878 R 373153 CDS YP_817092.1 116516671 4442451 complement(1656513..1658033) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1860; equivalent gene in S.pneumoniae R6 = spr1677; identified by match to protein family HMM PF00528; match to protein family HMM PF04069; choline transporter (glycine betaine transport system permease) 1658033 proWX 4442451 proWX Streptococcus pneumoniae D39 choline transporter (glycine betaine transport system permease) YP_817092.1 1656513 R 373153 CDS YP_817093.1 116515426 4442496 complement(1658026..1658754) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1861; equivalent gene in S.pneumoniae R6 = spr1678; identified by match to protein family HMM PF00005; choline transporter 1658754 proV 4442496 proV Streptococcus pneumoniae D39 choline transporter YP_817093.1 1658026 R 373153 CDS YP_817094.1 116516425 4441651 complement(1658769..1659533) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1862; equivalent gene in S.pneumoniae R6 = spr1679; identified by match to protein family HMM PF07366; hypothetical protein 1659533 4441651 SPD_1644 Streptococcus pneumoniae D39 hypothetical protein YP_817094.1 1658769 R 373153 CDS YP_817095.1 116516067 4442522 complement(1659537..1659980) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1863; equivalent gene in S.pneumoniae R6 = spr1680; identified by match to protein family HMM PF01047; transcriptional regulator, MarR family protein 1659980 4442522 SPD_1645 Streptococcus pneumoniae D39 transcriptional regulator, MarR family protein YP_817095.1 1659537 R 373153 CDS YP_817096.1 116516799 4442194 complement(1660662..1660958) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1864; equivalent gene in S.pneumoniae R6 = spr1681; hypothetical protein 1660958 4442194 SPD_1646 Streptococcus pneumoniae D39 hypothetical protein YP_817096.1 1660662 R 373153 CDS YP_817097.1 116516201 4441461 complement(1660980..1662044) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1865; equivalent gene in S.pneumoniae R6 = spr1682; identified by match to protein family HMM PF05343; glutamyl aminopeptidase PepA 1662044 pepA 4441461 pepA Streptococcus pneumoniae D39 glutamyl aminopeptidase PepA YP_817097.1 1660980 R 373153 CDS YP_817098.1 116515575 4442885 1662445..1663146 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1867; equivalent gene in S.pneumoniae R6 = spr1683; identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF07993; NAD-dependent epimerase/dehydratase family protein 1663146 4442885 SPD_1648 Streptococcus pneumoniae D39 NAD-dependent epimerase/dehydratase family protein YP_817098.1 1662445 D 373153 CDS YP_817099.1 116515914 4441057 1663569..1664528 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1869; equivalent gene in S.pneumoniae R6 = spr1684; identified by match to protein family HMM PF01032; iron-compound ABC transporter permease 1664528 4441057 SPD_1649 Streptococcus pneumoniae D39 iron-compound ABC transporter permease YP_817099.1 1663569 D 373153 CDS YP_817100.1 116517018 4441963 1664518..1665474 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1870; equivalent gene in S.pneumoniae R6 = spr1685; identified by match to protein family HMM PF01032; iron-compound ABC transporter permease 1665474 4441963 SPD_1650 Streptococcus pneumoniae D39 iron-compound ABC transporter permease YP_817100.1 1664518 D 373153 CDS YP_817101.1 116515957 4441398 1665471..1666223 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1871; equivalent gene in S.pneumoniae R6 = spr1686; identified by match to protein family HMM PF00005; iron-compound ABC transporter ATP-binding protein 1666223 4441398 SPD_1651 Streptococcus pneumoniae D39 iron-compound ABC transporter ATP-binding protein YP_817101.1 1665471 D 373153 CDS YP_817102.1 116515347 4441089 1666319..1667284 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1872; equivalent gene in S.pneumoniae R6 = spr1687; identified by match to protein family HMM PF01497; iron-compound ABC transporter iron-compound-binding protein 1667284 4441089 SPD_1652 Streptococcus pneumoniae D39 iron-compound ABC transporter iron-compound-binding protein YP_817102.1 1666319 D 373153 CDS YP_817103.1 116516197 4441456 complement(1667509..1667751) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1873; equivalent gene in S.pneumoniae R6 = spr1688; identified by match to protein family HMM PF01809; match to protein family HMM TIGR00278; hypothetical protein 1667751 4441456 SPD_1653 Streptococcus pneumoniae D39 hypothetical protein YP_817103.1 1667509 R 373153 CDS YP_817104.1 116515785 4441550 complement(1667751..1668473) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1874; equivalent gene in S.pneumoniae R6 = spr1689; identified by match to protein family HMM PF00849; match to protein family HMM PF01479; match to protein family HMM TIGR00093; ribosomal large subunit pseudouridine synthase B 1668473 rluB 4441550 rluB Streptococcus pneumoniae D39 ribosomal large subunit pseudouridine synthase B YP_817104.1 1667751 R 373153 CDS YP_817105.1 116516630 4441419 complement(1668460..1669029) 1 NC_008533.1 functions during chromosome segregation; may form a condensin-like structure with SMC and ScpA; forms a homodimer; segregation and condensation protein B 1669029 scpB 4441419 scpB Streptococcus pneumoniae D39 segregation and condensation protein B YP_817105.1 1668460 R 373153 CDS YP_817106.1 116516005 4441509 complement(1669048..1669776) 1 NC_008533.1 functions during chromosome segregation; may form a condensin-like structure with SMC and ScpB; segregation and condensation protein A 1669776 scpA 4441509 scpA Streptococcus pneumoniae D39 segregation and condensation protein A YP_817106.1 1669048 R 373153 CDS YP_817107.1 116517040 4442354 complement(1669776..1670516) 1 NC_008533.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD 1670516 xerD 4442354 xerD Streptococcus pneumoniae D39 site-specific tyrosine recombinase XerD YP_817107.1 1669776 R 373153 CDS YP_817108.1 116515694 4441435 complement(1670507..1670968) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1878; equivalent gene in S.pneumoniae R6 = spr1693; identified by match to protein family HMM PF00571; hypothetical protein 1670968 4441435 SPD_1658 Streptococcus pneumoniae D39 hypothetical protein YP_817108.1 1670507 R 373153 CDS YP_817109.1 116516789 4442242 complement(1670965..1671486) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1879; equivalent gene in S.pneumoniae R6 = spr1694; identified by match to protein family HMM PF00149; match to protein family HMM TIGR00040; hypothetical protein 1671486 4442242 SPD_1659 Streptococcus pneumoniae D39 hypothetical protein YP_817109.1 1670965 R 373153 CDS YP_817110.1 116515496 4441306 complement(1671462..1672433) 1 NC_008533.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein 1672433 4441306 SPD_1660 Streptococcus pneumoniae D39 deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein YP_817110.1 1671462 R 373153 CDS YP_817111.1 116516596 4441225 complement(1672430..1673224) 1 NC_008533.1 converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 1673224 murI 4441225 murI Streptococcus pneumoniae D39 glutamate racemase YP_817111.1 1672430 R 373153 CDS YP_817112.1 116516372 4443034 complement(1673431..1673679) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1882; equivalent gene in S.pneumoniae R6 = spr1697; hypothetical protein 1673679 4443034 SPD_1662 Streptococcus pneumoniae D39 hypothetical protein YP_817112.1 1673431 R 373153 CDS YP_817113.1 116515529 4442894 complement(1673821..1675446) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1883; equivalent gene in S.pneumoniae R6 = spr1698; identified by match to protein family HMM PF00128; match to protein family HMM TIGR02403; alpha,alpha-phosphotrehalase 1675446 treC 4442894 treC Streptococcus pneumoniae D39 alpha,alpha-phosphotrehalase YP_817113.1 1673821 R 373153 CDS YP_817114.1 116517080 4441930 complement(1675624..1677591) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1884; equivalent gene in S.pneumoniae R6 = spr1699; identified by match to protein family HMM PF00358; match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826; match to protein family HMM TIGR00830; match to protein family HMM TIGR01992; PTS system, trehalose-specific IIABC components 1677591 4441930 SPD_1664 Streptococcus pneumoniae D39 PTS system, trehalose-specific IIABC components YP_817114.1 1675624 R 373153 CDS YP_817115.1 116515994 4441497 1677776..1678486 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1885; equivalent gene in S.pneumoniae R6 = spr1700; identified by match to protein family HMM PF00392; match to protein family HMM PF07702; match to protein family HMM TIGR02404; trehalose operon repressor 1678486 treR 4441497 treR Streptococcus pneumoniae D39 trehalose operon repressor YP_817115.1 1677776 D 373153 CDS YP_817116.1 116516555 4441260 complement(1680023..1680949) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1887; equivalent gene in S.pneumoniae R6 = spr1703; identified by match to protein family HMM PF00005; oligopeptide ABC transporter ATP-binding protein AmiF 1680949 amiF 4441260 amiF Streptococcus pneumoniae D39 oligopeptide ABC transporter ATP-binding protein AmiF YP_817116.1 1680023 R 373153 CDS YP_817117.1 116515459 4441184 complement(1680960..1682027) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1888; equivalent gene in S.pneumoniae R6 = spr1704; identified by match to protein family HMM PF00005; match to protein family HMM TIGR01727; oligopeptide ABC transporter ATP-binding protein AmiE 1682027 amiE 4441184 amiE Streptococcus pneumoniae D39 oligopeptide ABC transporter ATP-binding protein AmiE YP_817117.1 1680960 R 373153 CDS YP_817118.1 116516298 4442587 complement(1682036..1682962) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1889; equivalent gene in S.pneumoniae R6 = spr1705; identified by match to protein family HMM PF00528; oligopeptide ABC transporter permease AmiD 1682962 amiD 4442587 amiD Streptococcus pneumoniae D39 oligopeptide ABC transporter permease AmiD YP_817118.1 1682036 R 373153 CDS YP_817119.1 116517087 4441898 complement(1682962..1684458) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1890; equivalent gene in S.pneumoniae R6 = spr1706; identified by match to protein family HMM PF00528; oligopeptide ABC transporter permease AmiC 1684458 amiC 4441898 amiC Streptococcus pneumoniae D39 oligopeptide ABC transporter permease AmiC YP_817119.1 1682962 R 373153 CDS YP_817120.1 116515355 4441155 complement(1684525..1686504) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1891; equivalent gene in S.pneumoniae R6 = spr1707; identified by match to protein family HMM PF00496; oligopeptide ABC transporter oligopeptide-binding protein AmiA 1686504 amiA 4441155 amiA Streptococcus pneumoniae D39 oligopeptide ABC transporter oligopeptide-binding protein AmiA YP_817120.1 1684525 R 373153 CDS YP_817121.1 116516720 4442308 complement(1687191..1688384) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1893; equivalent gene in S.pneumoniae R6 = spr1708; identified by match to protein family HMM PF04932; hypothetical protein 1688384 4442308 SPD_1672 Streptococcus pneumoniae D39 hypothetical protein YP_817121.1 1687191 R 373153 CDS YP_817122.1 116515647 4441327 complement(1688522..1689964) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1894; equivalent gene in S.pneumoniae R6 = spr1709; identified by match to protein family HMM PF00128; sucrose phosphorylase 1689964 gtfA 4441327 gtfA Streptococcus pneumoniae D39 sucrose phosphorylase YP_817122.1 1688522 R 373153 CDS YP_817123.1 116516930 4442045 complement(1690148..1690315) 1 NC_008533.1 hypothetical protein 1690315 4442045 SPD_1674 Streptococcus pneumoniae D39 hypothetical protein YP_817123.1 1690148 R 373153 CDS YP_817124.1 116516219 4441479 complement(1690322..1691155) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1895; equivalent gene in S.pneumoniae R6 = spr1710; identified by match to protein family HMM PF00528; sugar ABC transporter permease 1691155 rafG 4441479 rafG Streptococcus pneumoniae D39 sugar ABC transporter permease YP_817124.1 1690322 R 373153 CDS YP_817125.1 116517088 4441899 complement(1691169..1692035) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1896; equivalent gene in S.pneumoniae R6 = spr1711; identified by match to protein family HMM PF00528; sugar ABC transporter permease 1692035 rafF 4441899 rafF Streptococcus pneumoniae D39 sugar ABC transporter permease YP_817125.1 1691169 R 373153 CDS YP_817126.1 116516419 4442985 complement(1692049..1693308) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1897; equivalent gene in S.pneumoniae R6 = spr1712; identified by match to protein family HMM PF01547; sugar ABC transporter sugar-binding protein 1693308 rafE 4442985 rafE Streptococcus pneumoniae D39 sugar ABC transporter sugar-binding protein YP_817126.1 1692049 R 373153 CDS YP_817127.1 116515396 4442466 complement(1693400..1695562) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1898; equivalent gene in S.pneumoniae R6 = spr1713; identified by match to protein family HMM PF02065; alpha-galactosidase AgaN 1695562 aga 4442466 aga Streptococcus pneumoniae D39 alpha-galactosidase AgaN YP_817127.1 1693400 R 373153 CDS YP_817128.1 116516533 4443084 1695670..1696530 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1899; equivalent gene in S.pneumoniae R6 = spr1714; identified by match to protein family HMM PF00165; match to protein family HMM PF02311; msm operon regulatory protein MsmR 1696530 msmR 4443084 msmR Streptococcus pneumoniae D39 msm operon regulatory protein MsmR YP_817128.1 1695670 D 373153 CDS YP_817129.1 116515717 4442254 1696527..1697462 1 NC_008533.1 catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; biotin--protein ligase 1697462 4442254 SPD_1680 Streptococcus pneumoniae D39 biotin--protein ligase YP_817129.1 1696527 D 373153 CDS YP_817130.1 116516423 4441649 complement(1705095..1706450) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1901; equivalent gene in S.pneumoniae R6 = spr1717; identified by match to protein family HMM PF01938; match to protein family HMM PF05958; match to protein family HMM TIGR00479; 23S rRNA (uracil-5-)-methyltransferase RumA 1706450 rumA-2 4441649 rumA-2 Streptococcus pneumoniae D39 23S rRNA (uracil-5-)-methyltransferase RumA YP_817130.1 1705095 R 373153 CDS YP_817131.1 116516281 4442609 1706488..1707264 1 NC_008533.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 1707264 recX 4442609 recX Streptococcus pneumoniae D39 recombination regulator RecX YP_817131.1 1706488 D 373153 CDS YP_817132.1 116516443 4442562 1707353..1707886 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1903; equivalent gene in S.pneumoniae R6 = spr1719; identified by match to protein family HMM PF04167; hypothetical protein 1707886 4442562 SPD_1706 Streptococcus pneumoniae D39 hypothetical protein YP_817132.1 1707353 D 373153 CDS YP_817133.1 116515970 4442421 complement(1708240..1708446) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1904; equivalent gene in S.pneumoniae R6 = spr1720; hypothetical protein 1708446 4442421 SPD_1707 Streptococcus pneumoniae D39 hypothetical protein YP_817133.1 1708240 R 373153 CDS YP_817134.1 116516793 4442246 1708606..1709835 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1262; equivalent gene in S.pneumoniae R6 = spr1721; identified by match to protein family HMM PF01610; IS1167, transposase 1709835 4442246 SPD_1708 Streptococcus pneumoniae D39 IS1167, transposase YP_817134.1 1708606 D 373153 CDS YP_817135.1 116516636 4441425 complement(1709934..1711556) 1 NC_008533.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; chaperonin GroEL 1711556 groEL 4441425 groEL Streptococcus pneumoniae D39 chaperonin GroEL YP_817135.1 1709934 R 373153 CDS YP_817136.1 116516929 4442043 complement(1711572..1711856) 1 NC_008533.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 1711856 groES 4442043 groES Streptococcus pneumoniae D39 co-chaperonin GroES YP_817136.1 1711572 R 373153 CDS YP_817137.1 116515814 4442861 complement(1712012..1712407) 1 NC_008533.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA; single-stranded DNA-binding protein 1712407 4442861 SPD_1711 Streptococcus pneumoniae D39 single-stranded DNA-binding protein YP_817137.1 1712012 R 373153 CDS YP_817138.1 116516362 4442964 complement(1712485..1713246) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1909; equivalent gene in S.pneumoniae R6 = spr1725; identified by match to protein family HMM PF00106; short chain dehydrogenase/reductase family oxidoreductase 1713246 4442964 SPD_1712 Streptococcus pneumoniae D39 short chain dehydrogenase/reductase family oxidoreductase YP_817138.1 1712485 R 373153 CDS YP_817139.1 116515611 4442750 complement(1713279..1713905) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1910; equivalent gene in S.pneumoniae R6 = spr1726; identified by match to protein family HMM PF01588; hypothetical protein 1713905 4442750 SPD_1713 Streptococcus pneumoniae D39 hypothetical protein YP_817139.1 1713279 R 373153 CDS YP_817140.1 116517084 4441934 complement(1713921..1714238) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1911; equivalent gene in S.pneumoniae R6 = spr1727; identified by match to protein family HMM PF00085; thioredoxin family protein 1714238 4441934 SPD_1714 Streptococcus pneumoniae D39 thioredoxin family protein YP_817140.1 1713921 R 373153 CDS YP_817141.1 116516247 4441527 complement(1714235..1714534) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1912; equivalent gene in S.pneumoniae R6 = spr1728; hypothetical protein 1714534 4441527 SPD_1715 Streptococcus pneumoniae D39 hypothetical protein YP_817141.1 1714235 R 373153 CDS YP_817142.1 116515657 4441240 complement(1714871..1715062) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1729; identified by match to protein family HMM PF01473; hypothetical protein 1715062 4441240 SPD_1716 Streptococcus pneumoniae D39 hypothetical protein YP_817142.1 1714871 R 373153 CDS YP_817143.1 116516511 4442632 complement(1715223..1715897) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1914; equivalent gene in S.pneumoniae R6 = spr1730; hypothetical protein 1715897 4442632 SPD_1717 Streptococcus pneumoniae D39 hypothetical protein YP_817143.1 1715223 R 373153 CDS YP_817144.1 116515993 4441496 complement(1715903..1716349) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1915; equivalent gene in S.pneumoniae R6 = spr1731; identified by match to protein family HMM PF04397; hypothetical protein 1716349 4441496 SPD_1718 Streptococcus pneumoniae D39 hypothetical protein YP_817144.1 1715903 R 373153 CDS YP_817145.1 116516557 4441262 complement(1716463..1716966) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1916; equivalent gene in S.pneumoniae R6 = spr1732; identified by match to protein family HMM PF01569; PAP2 family protein 1716966 4441262 SPD_1719 Streptococcus pneumoniae D39 PAP2 family protein YP_817145.1 1716463 R 373153 CDS YP_817146.1 116515659 4441242 complement(1716963..1717325) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1917; equivalent gene in S.pneumoniae R6 = spr1733; hypothetical protein 1717325 4441242 SPD_1720 Streptococcus pneumoniae D39 hypothetical protein YP_817146.1 1716963 R 373153 CDS YP_817147.1 116516021 4441583 complement(1717391..1718422) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1918; equivalent gene in S.pneumoniae R6 = spr1734; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1718422 4441583 SPD_1721 Streptococcus pneumoniae D39 ABC transporter ATP-binding protein YP_817147.1 1717391 R 373153 CDS YP_817148.1 116516096 4442690 complement(1719267..1719380) 1 NC_008533.1 hypothetical protein 1719380 4442690 SPD_1723 Streptococcus pneumoniae D39 hypothetical protein YP_817148.1 1719267 R 373153 CDS YP_817149.1 116517178 4441854 complement(1719860..1720576) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1922; equivalent gene in S.pneumoniae R6 = spr1738; identified by match to protein family HMM PF01709; match to protein family HMM TIGR01033; hypothetical protein 1720576 4441854 SPD_1725 Streptococcus pneumoniae D39 hypothetical protein YP_817149.1 1719860 R 373153 CDS YP_817150.1 116515376 4441611 complement(1721457..1722872) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1923; equivalent gene in S.pneumoniae R6 = spr1739; identified by match to protein family HMM PF01289; pneumolysin 1722872 ply 4441611 ply Streptococcus pneumoniae D39 pneumolysin YP_817150.1 1721457 R 373153 CDS YP_817151.1 116516591 4441220 complement(1722883..1723293) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1924; equivalent gene in S.pneumoniae R6 = spr1740; hypothetical protein 1723293 4441220 SPD_1727 Streptococcus pneumoniae D39 hypothetical protein YP_817151.1 1722883 R 373153 CDS YP_817152.1 116515483 4442653 complement(1723286..1723894) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1925; equivalent gene in S.pneumoniae R6 = spr1741; hypothetical protein 1723894 4442653 SPD_1728 Streptococcus pneumoniae D39 hypothetical protein YP_817152.1 1723286 R 373153 CDS YP_817153.1 116515874 4441112 complement(1723907..1724365) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1926; equivalent gene in S.pneumoniae R6 = spr1742 This gene has a frameshift at amaino acid 96 relative to its R6 equivalent gene but not its TIGR4 equivalent gene.; hypothetical protein 1724365 4441112 SPD_1729 Streptococcus pneumoniae D39 hypothetical protein YP_817153.1 1723907 R 373153 CDS YP_817154.1 116516597 4441227 complement(1725654..1725914) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1930; equivalent gene in S.pneumoniae R6 = spr1746; hypothetical protein 1725914 4441227 SPD_1731 Streptococcus pneumoniae D39 hypothetical protein YP_817154.1 1725654 R 373153 CDS YP_817155.1 116516601 4441231 complement(1725973..1726524) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1931; equivalent gene in S.pneumoniae R6 = spr1747; hypothetical protein 1726524 4441231 SPD_1732 Streptococcus pneumoniae D39 hypothetical protein YP_817155.1 1725973 R 373153 CDS YP_817156.1 116516964 4442917 complement(1726514..1726711) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1932; equivalent gene in S.pneumoniae R6 = spr1748; hypothetical protein 1726711 4442917 SPD_1733 Streptococcus pneumoniae D39 hypothetical protein YP_817156.1 1726514 R 373153 CDS YP_817157.1 116517008 4441992 complement(1726715..1727509) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1933; equivalent gene in S.pneumoniae R6 = spr1749; hypothetical protein 1727509 4441992 SPD_1734 Streptococcus pneumoniae D39 hypothetical protein YP_817157.1 1726715 R 373153 CDS YP_817158.1 116516198 4441458 complement(1727917..1728342) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1934; equivalent gene in S.pneumoniae R6 = spr1750; hypothetical protein 1728342 4441458 SPD_1735 Streptococcus pneumoniae D39 hypothetical protein YP_817158.1 1727917 R 373153 CDS YP_817159.1 116516167 4442841 complement(1728471..1728830) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1935; equivalent gene in S.pneumoniae R6 = spr1751; hypothetical protein 1728830 4442841 SPD_1736 Streptococcus pneumoniae D39 hypothetical protein YP_817159.1 1728471 R 373153 CDS YP_817160.1 116516777 4442230 complement(1729601..1730557) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1937; equivalent gene in S.pneumoniae R6 = spr1754; identified by match to protein family HMM PF01473; match to protein family HMM PF01510; autolysin/N-acetylmuramoyl-L-alanine amidase 1730557 lytA 4442230 lytA Streptococcus pneumoniae D39 autolysin/N-acetylmuramoyl-L-alanine amidase YP_817160.1 1729601 R 373153 CDS YP_817161.1 116517012 4441957 complement(1730933..1732303) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1939; equivalent gene in S.pneumoniae R6 = spr1756; identified by match to protein family HMM PF01554; match to protein family HMM TIGR00797; MATE efflux family protein DinF 1732303 dinF 4441957 dinF Streptococcus pneumoniae D39 MATE efflux family protein DinF YP_817161.1 1730933 R 373153 CDS YP_817162.1 116516275 4442603 complement(1732610..1733776) 1 NC_008533.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A 1733776 recA 4442603 recA Streptococcus pneumoniae D39 recombinase A YP_817162.1 1732610 R 373153 CDS YP_817163.1 116515783 4441683 complement(1733831..1735087) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1941; equivalent gene in S.pneumoniae R6 = spr1758; identified by match to protein family HMM PF00994; match to protein family HMM PF02464; match to protein family HMM TIGR00199; match to protein family HMM TIGR00200; competence damage-inducible protein A 1735087 cinA 4441683 cinA Streptococcus pneumoniae D39 competence damage-inducible protein A YP_817163.1 1733831 R 373153 CDS YP_817164.1 116516376 4443038 complement(1735172..1736188) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1942; equivalent gene in S.pneumoniae R6 = spr1759; identified by match to protein family HMM PF03816; match to protein family HMM TIGR00350; transcriptional regulator 1736188 4443038 SPD_1741 Streptococcus pneumoniae D39 transcriptional regulator YP_817164.1 1735172 R 373153 CDS YP_817165.1 116516759 4442270 complement(1736196..1736714) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1943; equivalent gene in S.pneumoniae R6 = spr1760; identified by match to protein family HMM PF00583; GNAT family acetyltransferase 1736714 4442270 SPD_1742 Streptococcus pneumoniae D39 GNAT family acetyltransferase YP_817165.1 1736196 R 373153 CDS YP_817166.1 116515913 4441056 complement(1736704..1737147) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1944; equivalent gene in S.pneumoniae R6 = spr1761; identified by match to protein family HMM PF02367; match to protein family HMM TIGR00150; hypothetical protein 1737147 4441056 SPD_1743 Streptococcus pneumoniae D39 hypothetical protein YP_817166.1 1736704 R 373153 CDS YP_817167.1 116516234 4441514 complement(1737233..1737853) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1945; equivalent gene in S.pneumoniae R6 = spr1762; hypothetical protein 1737853 4441514 SPD_1744 Streptococcus pneumoniae D39 hypothetical protein YP_817167.1 1737233 R 373153 CDS YP_817168.1 116517204 4441802 complement(1738236..1739099) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1946; equivalent gene in S.pneumoniae R6 = spr1763; identified by match to protein family HMM PF01381; transcriptional regulator PlcR 1739099 4441802 SPD_1745 Streptococcus pneumoniae D39 transcriptional regulator PlcR YP_817168.1 1738236 R 373153 CDS YP_817169.1 116516150 4442512 1739291..1739461 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1947; equivalent gene in S.pneumoniae R6 = spr1764; hypothetical protein 1739461 4442512 SPD_1746 Streptococcus pneumoniae D39 hypothetical protein YP_817169.1 1739291 D 373153 CDS YP_817170.1 116516307 4442596 1739564..1739788 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1948; equivalent gene in S.pneumoniae R6 = spr1765; hypothetical protein 1739788 4442596 SPD_1747 Streptococcus pneumoniae D39 hypothetical protein YP_817170.1 1739564 D 373153 CDS YP_817171.1 116515563 4442873 1739795..1739983 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1949; equivalent gene in S.pneumoniae R6 = spr1766; hypothetical protein 1739983 4442873 SPD_1748 Streptococcus pneumoniae D39 hypothetical protein YP_817171.1 1739795 D 373153 CDS YP_817172.1 116516640 4441429 1740099..1743089 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1950; equivalent gene in S.pneumoniae R6 = spr1767; identified by match to protein family HMM PF05147; bacteriocin formation protein 1743089 4441429 SPD_1749 Streptococcus pneumoniae D39 bacteriocin formation protein YP_817172.1 1740099 D 373153 CDS YP_817173.1 116516852 4442133 1743439..1744143 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1951; equivalent gene in S.pneumoniae R6 = spr1768 The crystal structure of this protein is published; identified by similarity to GB:1SQS_A; hypothetical protein 1744143 wrbA 4442133 wrbA Streptococcus pneumoniae D39 hypothetical protein YP_817173.1 1743439 D 373153 CDS YP_817174.1 116516025 4441685 1744124..1745053 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1952; equivalent gene in S.pneumoniae R6 = spr1769; hypothetical protein 1745053 4441685 SPD_1751 Streptococcus pneumoniae D39 hypothetical protein YP_817174.1 1744124 D 373153 CDS YP_817175.1 116516806 4442202 1745050..1747158 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1953; equivalent gene in S.pneumoniae R6 = spr1770; identified by match to protein family HMM PF00005; match to protein family HMM PF00664; match to protein family HMM PF03412; toxin secretion ABC transporter ATP-binding protein/permease 1747158 4442202 SPD_1752 Streptococcus pneumoniae D39 toxin secretion ABC transporter ATP-binding protein/permease YP_817175.1 1745050 D 373153 CDS YP_817176.1 116515961 4441402 1747182..1748921 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1954; equivalent gene in S.pneumoniae R6 = spr1771; identified by match to protein family HMM PF00082; subtilase family serine protease 1748921 4441402 SPD_1753 Streptococcus pneumoniae D39 subtilase family serine protease YP_817176.1 1747182 D 373153 CDS YP_817177.1 116517021 4441966 1748972..1749739 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1956; equivalent gene in S.pneumoniae R6 = spr1772; identified by match to protein family HMM PF07242; hypothetical protein 1749739 4441966 SPD_1754 Streptococcus pneumoniae D39 hypothetical protein YP_817177.1 1748972 D 373153 CDS YP_817178.1 116516211 4441471 1749741..1750373 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1957; equivalent gene in S.pneumoniae R6 = spr1773; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1750373 4441471 SPD_1755 Streptococcus pneumoniae D39 ABC transporter ATP-binding protein YP_817178.1 1749741 D 373153 CDS YP_817179.1 116516632 4441421 1750531..1750692 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1958; equivalent gene in S.pneumoniae R6 = spr1774; hypothetical protein 1750692 4441421 SPD_1756 Streptococcus pneumoniae D39 hypothetical protein YP_817179.1 1750531 D 373153 CDS YP_817180.1 116516942 4442018 complement(1751319..1751732) 1 NC_008533.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase 1751732 ndk 4442018 ndk Streptococcus pneumoniae D39 nucleoside diphosphate kinase YP_817180.1 1751319 R 373153 CDS YP_817181.1 116515724 4442262 complement(1751843..1755520) 1 NC_008533.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 1755520 rpoC 4442262 rpoC Streptococcus pneumoniae D39 DNA-directed RNA polymerase subunit beta' YP_817181.1 1751843 R 373153 CDS YP_817182.1 116516435 4441661 complement(1755553..1759164) 1 NC_008533.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 1759164 rpoB 4441661 rpoB Streptococcus pneumoniae D39 DNA-directed RNA polymerase subunit beta YP_817182.1 1755553 R 373153 CDS YP_817183.1 116515537 4442902 complement(1759848..1761179) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1963; equivalent gene in S.pneumoniae R6 = spr1778; identified by match to protein family HMM PF00571; match to protein family HMM PF01595; match to protein family HMM PF03471; hypothetical protein 1761179 4442902 SPD_1761 Streptococcus pneumoniae D39 hypothetical protein YP_817183.1 1759848 R 373153 CDS YP_817184.1 116516431 4441657 complement(1761408..1762232) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1964; equivalent gene in S.pneumoniae R6 = spr1779; identified by match to protein family HMM PF01223; DNA-entry nuclease 1762232 4441657 SPD_1762 Streptococcus pneumoniae D39 DNA-entry nuclease YP_817184.1 1761408 R 373153 CDS YP_817185.1 116516278 4442606 complement(1762271..1762477) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1965; equivalent gene in S.pneumoniae R6 = spr1780; hypothetical protein 1762477 4442606 SPD_1763 Streptococcus pneumoniae D39 hypothetical protein YP_817185.1 1762271 R 373153 CDS YP_817186.1 116516843 4442163 complement(1762452..1763735) 1 NC_008533.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1763735 murA-2 4442163 murA-2 Streptococcus pneumoniae D39 UDP-N-acetylglucosamine 1-carboxyvinyltransferase YP_817186.1 1762452 R 373153 CDS YP_817187.1 116516010 4441572 complement(1764047..1765084) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1967; equivalent gene in S.pneumoniae R6 = spr1782; hypothetical protein 1765084 4441572 SPD_1765 Streptococcus pneumoniae D39 hypothetical protein YP_817187.1 1764047 R 373153 CDS YP_817188.1 116515643 4441323 complement(1765068..1765556) 1 NC_008533.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 1765556 coaD 4441323 coaD Streptococcus pneumoniae D39 phosphopantetheine adenylyltransferase YP_817188.1 1765068 R 373153 CDS YP_817189.1 116516705 4442331 complement(1765546..1766085) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1969; equivalent gene in S.pneumoniae R6 = spr1784; identified by match to protein family HMM PF03602; match to protein family HMM TIGR00095; type II DNA modification methyltransferase 1766085 4442331 SPD_1767 Streptococcus pneumoniae D39 type II DNA modification methyltransferase YP_817189.1 1765546 R 373153 CDS YP_817190.1 116515784 4441684 complement(1766150..1767142) 1 NC_008533.1 catalyzes the formation of asparagine from aspartate and ammonia; asparagine synthetase AsnA 1767142 asnA 4441684 asnA Streptococcus pneumoniae D39 asparagine synthetase AsnA YP_817190.1 1766150 R 373153 CDS YP_817191.1 116515931 4441074 1767122..1767280 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1971; equivalent gene in S.pneumoniae R6 = spr1786; hypothetical protein 1767280 4441074 SPD_1770 Streptococcus pneumoniae D39 hypothetical protein YP_817191.1 1767122 D 373153 CDS YP_817192.1 116516865 4442147 complement(1767254..1767961) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1972; equivalent gene in S.pneumoniae R6 = spr1787; identified by match to protein family HMM PF01027; hypothetical protein 1767961 4442147 SPD_1769 Streptococcus pneumoniae D39 hypothetical protein YP_817192.1 1767254 R 373153 CDS YP_817193.1 116516909 4442057 complement(1767993..1768733) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1973; equivalent gene in S.pneumoniae R6 = spr1788; identified by match to protein family HMM PF00588; match to protein family HMM PF08032; SpoU rRNA methylase family protein 1768733 4442057 SPD_1771 Streptococcus pneumoniae D39 SpoU rRNA methylase family protein YP_817193.1 1767993 R 373153 CDS YP_817194.1 116516230 4441490 1768782..1769045 1 NC_008533.1 catalyzes the hydrolysis of acylphosphate; acylphosphatase 1769045 4441490 SPD_1772 Streptococcus pneumoniae D39 acylphosphatase YP_817194.1 1768782 D 373153 CDS YP_817195.1 116517062 4441950 1769123..1770049 1 NC_008533.1 involved in biogenesis of membrane proteins; Firmicutes specific proteins are shorter than other bacterial counterparts and have a signal peptide and lipid attachment site; OxaA-like protein precursor 1770049 4441950 SPD_1773 Streptococcus pneumoniae D39 OxaA-like protein precursor YP_817195.1 1769123 D 373153 CDS YP_817196.1 116516256 4441766 complement(1770124..1770918) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1976; equivalent gene in S.pneumoniae R6 = spr1791; identified by match to protein family HMM PF04055; match to protein family HMM TIGR02493; pyruvate formate-lyase activating enzyme 1770918 pflA 4441766 pflA Streptococcus pneumoniae D39 pyruvate formate-lyase activating enzyme YP_817196.1 1770124 R 373153 CDS YP_817197.1 116516303 4442592 complement(1771044..1772294) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1978; equivalent gene in S.pneumoniae R6 = spr1792; identified by match to protein family HMM PF00278; match to protein family HMM PF02784; diaminopimelate decarboxylase 1772294 lysA 4442592 lysA Streptococcus pneumoniae D39 diaminopimelate decarboxylase YP_817197.1 1771044 R 373153 CDS YP_817198.1 116515481 4442651 complement(1772361..1773188) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1979; equivalent gene in S.pneumoniae R6 = spr1793; identified by match to protein family HMM PF00156; match to protein family HMM TIGR01743; pur operon repressor 1773188 purR 4442651 purR Streptococcus pneumoniae D39 pur operon repressor YP_817198.1 1772361 R 373153 CDS YP_817199.1 116516594 4441223 complement(1773455..1774408) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1980; equivalent gene in S.pneumoniae R6 = spr1794; identified by match to protein family HMM PF01336; cmp-binding-factor 1 1774408 cbf1 4441223 cbf1 Streptococcus pneumoniae D39 cmp-binding-factor 1 YP_817199.1 1773455 R 373153 CDS YP_817200.1 116516808 4442204 complement(1774386..1775642) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1981; equivalent gene in S.pneumoniae R6 = spr1795; identified by match to protein family HMM PF02646; hypothetical protein 1775642 4442204 SPD_1778 Streptococcus pneumoniae D39 hypothetical protein YP_817200.1 1774386 R 373153 CDS YP_817201.1 116516589 4441218 complement(1775644..1776306) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1982; equivalent gene in S.pneumoniae R6 = spr1796; identified by match to protein family HMM PF04263; match to protein family HMM PF04265; match to protein family HMM TIGR01378; hypothetical protein 1776306 4441218 SPD_1779 Streptococcus pneumoniae D39 hypothetical protein YP_817201.1 1775644 R 373153 CDS YP_817202.1 116515540 4442906 complement(1776269..1776925) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1983; equivalent gene in S.pneumoniae R6 = spr1797; identified by match to protein family HMM PF00834; match to protein family HMM TIGR01163; ribulose-phosphate 3-epimerase 1776925 rpe 4442906 rpe Streptococcus pneumoniae D39 ribulose-phosphate 3-epimerase YP_817202.1 1776269 R 373153 CDS YP_817203.1 116516502 4442623 complement(1776936..1777814) 1 NC_008533.1 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity; ribosome-associated GTPase 1777814 rsgA 4442623 rsgA Streptococcus pneumoniae D39 ribosome-associated GTPase YP_817203.1 1776936 R 373153 CDS YP_817204.1 116515767 4441667 complement(1777816..1778688) 1 NC_008533.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 1778688 ksgA 4441667 ksgA Streptococcus pneumoniae D39 dimethyladenosine transferase YP_817204.1 1777816 R 373153 CDS YP_817205.1 116517198 4441835 complement(1778819..1779127) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1986; equivalent gene in S.pneumoniae R6 = spr1800; hypothetical protein 1779127 4441835 SPD_1783 Streptococcus pneumoniae D39 hypothetical protein YP_817205.1 1778819 R 373153 CDS YP_817206.1 116515516 4442997 complement(1779120..1779761) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1987; equivalent gene in S.pneumoniae R6 = spr1801; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1779761 4442997 SPD_1784 Streptococcus pneumoniae D39 ABC transporter ATP-binding protein YP_817206.1 1779120 R 373153 CDS YP_817207.1 116516767 4442278 complement(1779763..1781793) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1988; equivalent gene in S.pneumoniae R6 = spr1802; identified by match to protein family HMM PF07242; match to protein family HMM TIGR01654; immunity protein 1781793 4442278 SPD_1785 Streptococcus pneumoniae D39 immunity protein YP_817207.1 1779763 R 373153 CDS YP_817208.1 116516188 4441145 complement(1782062..1782961) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1989; equivalent gene in S.pneumoniae R6 = spr1803; identified by match to protein family HMM PF01381; transcriptional regulator PlcR 1782961 4441145 SPD_1786 Streptococcus pneumoniae D39 transcriptional regulator PlcR YP_817208.1 1782062 R 373153 CDS YP_817209.1 116515737 4441025 complement(1783033..1783593) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1990; equivalent gene in S.pneumoniae R6 = spr1804; identified by match to protein family HMM PF01751; match to protein family HMM TIGR00334; primase-like protein 1783593 4441025 SPD_1787 Streptococcus pneumoniae D39 primase-like protein YP_817209.1 1783033 R 373153 CDS YP_817210.1 116516605 4441235 complement(1783593..1784366) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1991; equivalent gene in S.pneumoniae R6 = spr1805; identified by match to protein family HMM PF01026; match to protein family HMM TIGR00010; TatD family hydrolase 1784366 4441235 SPD_1788 Streptococcus pneumoniae D39 TatD family hydrolase YP_817210.1 1783593 R 373153 CDS YP_817211.1 116516291 4442580 complement(1784672..1785337) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1992; equivalent gene in S.pneumoniae R6 = spr1806; identified by match to protein family HMM PF00746; match to protein family HMM TIGR01167; cell wall surface anchor family protein 1785337 4442580 SPD_1789 Streptococcus pneumoniae D39 cell wall surface anchor family protein YP_817211.1 1784672 R 373153 CDS YP_817212.1 116517079 4441929 complement(1785600..1785734) 1 NC_008533.1 in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 1785734 rpmH 4441929 rpmH Streptococcus pneumoniae D39 50S ribosomal protein L34 YP_817212.1 1785600 R 373153 CDS YP_817213.1 116516203 4441463 complement(1785879..1787093) 1 NC_008533.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase AlaT 1787093 4441463 SPD_1791 Streptococcus pneumoniae D39 aminotransferase AlaT YP_817213.1 1785879 R 373153 CDS YP_817214.1 116516320 4442803 complement(1787249..1787542) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1995; equivalent gene in S.pneumoniae R6 = spr1809; hypothetical protein 1787542 4442803 SPD_1792 Streptococcus pneumoniae D39 hypothetical protein YP_817214.1 1787249 R 373153 CDS YP_817215.1 116515416 4442486 1787704..1788156 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1996; equivalent gene in S.pneumoniae R6 = spr1810; identified by match to protein family HMM PF00582; universal stress protein family protein 1788156 4442486 SPD_1793 Streptococcus pneumoniae D39 universal stress protein family protein YP_817215.1 1787704 D 373153 CDS YP_817216.1 116516548 4441052 complement(1788191..1789579) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1997; equivalent gene in S.pneumoniae R6 = spr1811; identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484; Cof family protein 1789579 4441052 SPD_1794 Streptococcus pneumoniae D39 Cof family protein YP_817216.1 1788191 R 373153 CDS YP_817217.1 116515808 4442855 1789645..1790607 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1998; equivalent gene in S.pneumoniae R6 = spr1812; identified by match to protein family HMM PF00710; L-asparaginase 1790607 4442855 SPD_1796 Streptococcus pneumoniae D39 L-asparaginase YP_817217.1 1789645 D 373153 CDS YP_817218.1 116515675 4442541 complement(1790604..1790732) 1 NC_008533.1 hypothetical protein 1790732 4442541 SPD_1795 Streptococcus pneumoniae D39 hypothetical protein YP_817218.1 1790604 R 373153 CDS YP_817219.1 116517109 4441881 complement(1790859..1791869) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1999; equivalent gene in S.pneumoniae R6 = spr1813; identified by match to protein family HMM PF00356; match to protein family HMM PF00532; match to protein family HMM TIGR01481; catabolite control protein A 1791869 ccpA 4441881 ccpA Streptococcus pneumoniae D39 catabolite control protein A YP_817219.1 1790859 R 373153 CDS YP_817220.1 116516134 4442224 complement(1792294..1792893) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2000; equivalent gene in S.pneumoniae R6 = spr1814; identified by match to protein family HMM PF00072; match to protein family HMM PF00196; DNA-binding response regulator 1792893 4442224 SPD_1798 Streptococcus pneumoniae D39 DNA-binding response regulator YP_817220.1 1792294 R 373153 CDS YP_817221.1 116515432 4441279 complement(1792895..1793992) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2001; equivalent gene in S.pneumoniae R6 = spr1815; identified by match to protein family HMM PF02518; match to protein family HMM PF07730; sensor histidine kinase 1793992 4441279 SPD_1799 Streptococcus pneumoniae D39 sensor histidine kinase YP_817221.1 1792895 R 373153 CDS YP_817222.1 116516402 4442968 complement(1793992..1794729) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2002; equivalent gene in S.pneumoniae R6 = spr1816; identified by match to protein family HMM PF01061; hypothetical protein 1794729 4442968 SPD_1800 Streptococcus pneumoniae D39 hypothetical protein YP_817222.1 1793992 R 373153 CDS YP_817223.1 116516186 4441143 complement(1794731..1795615) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1817; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 1795615 4441143 SPD_1801 Streptococcus pneumoniae D39 ABC transporter ATP-binding protein YP_817223.1 1794731 R 373153 CDS YP_817224.1 116516158 4442832 complement(1795602..1795796) 1 NC_008533.1 hypothetical protein 1795796 4442832 SPD_1802 Streptococcus pneumoniae D39 hypothetical protein YP_817224.1 1795602 R 373153 CDS YP_817225.1 116515357 4441157 complement(1795793..1795972) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1818; hypothetical protein 1795972 4441157 SPD_1803 Streptococcus pneumoniae D39 hypothetical protein YP_817225.1 1795793 R 373153 CDS YP_817226.1 116515760 4442416 complement(1802678..1803157) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0014; equivalent gene in S.pneumoniae R6 = spr0013; transcriptional regulator ComX2 1803157 comX2 4442416 comX2 Streptococcus pneumoniae D39 transcriptional regulator ComX2 YP_817226.1 1802678 R 373153 CDS YP_817227.1 116515696 4441437 complement(1803279..1803815) 1 NC_008533.1 Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 1803815 nusG 4441437 nusG Streptococcus pneumoniae D39 transcription antitermination protein NusG YP_817227.1 1803279 R 373153 CDS YP_817228.1 116516864 4442146 complement(1803870..1804046) 1 NC_008533.1 forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 1804046 secE 4442146 secE Streptococcus pneumoniae D39 preprotein translocase subunit SecE YP_817228.1 1803870 R 373153 CDS YP_817229.1 116515999 4441503 complement(1804261..1806456) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2010; equivalent gene in S.pneumoniae R6 = spr1823; identified by match to protein family HMM PF00905; match to protein family HMM PF00912; match to protein family HMM TIGR02074; penicillin-binding protein 2A 1806456 pbp2A 4441503 pbp2A Streptococcus pneumoniae D39 penicillin-binding protein 2A YP_817229.1 1804261 R 373153 CDS YP_817230.1 116515727 4442265 1806543..1807418 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2011; equivalent gene in S.pneumoniae R6 = spr1824; identified by match to protein family HMM PF00849; ribosomal large subunit pseudouridine synthase, RluD subfamily protein 1807418 4442265 SPD_1822 Streptococcus pneumoniae D39 ribosomal large subunit pseudouridine synthase, RluD subfamily protein YP_817230.1 1806543 D 373153 CDS YP_817231.1 116516442 4442561 complement(1807486..1808493) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2012; equivalent gene in S.pneumoniae R6 = spr1825; identified by match to protein family HMM PF00044; match to protein family HMM PF02800; match to protein family HMM TIGR01534; glyceraldehyde-3-phosphate dehydrogenase 1808493 gap 4442561 gap Streptococcus pneumoniae D39 glyceraldehyde-3-phosphate dehydrogenase YP_817231.1 1807486 R 373153 CDS YP_817232.1 116515615 4442695 complement(1808670..1809632) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2013; equivalent gene in S.pneumoniae R6 = spr1826; identified by match to protein family HMM PF02687; hypothetical protein 1809632 4442695 SPD_1824 Streptococcus pneumoniae D39 hypothetical protein YP_817232.1 1808670 R 373153 CDS YP_817233.1 116516875 4442118 complement(1810656..1811528) 1 NC_008533.1 catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; nicotinate-nucleotide pyrophosphorylase 1811528 nadC 4442118 nadC Streptococcus pneumoniae D39 nicotinate-nucleotide pyrophosphorylase YP_817233.1 1810656 R 373153 CDS YP_817234.1 116517036 4442350 1811765..1813075 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2017; equivalent gene in S.pneumoniae R6 = spr1830; identified by match to protein family HMM PF03600; match to protein family HMM PF07158; hypothetical protein 1813075 4442350 SPD_1827 Streptococcus pneumoniae D39 hypothetical protein YP_817234.1 1811765 D 373153 CDS YP_817235.1 116515923 4441066 complement(1813441..1813572) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2019; equivalent gene in S.pneumoniae R6 = spr1831; hypothetical protein 1813572 4441066 SPD_1828 Streptococcus pneumoniae D39 hypothetical protein YP_817235.1 1813441 R 373153 CDS YP_817236.1 116516507 4442628 complement(1814095..1814823) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2020; equivalent gene in S.pneumoniae R6 = spr1832; identified by match to protein family HMM PF00392; match to protein family HMM PF07702; GntR family transcriptional regulator protein 1814823 4442628 SPD_1829 Streptococcus pneumoniae D39 GntR family transcriptional regulator protein YP_817236.1 1814095 R 373153 CDS YP_817237.1 116515373 4441608 1814981..1816390 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2021; equivalent gene in S.pneumoniae R6 = spr1833; identified by match to protein family HMM PF00232; glycosyl hydrolase family protein 1816390 4441608 SPD_1830 Streptococcus pneumoniae D39 glycosyl hydrolase family protein YP_817237.1 1814981 D 373153 CDS YP_817238.1 116515645 4441325 1816408..1817703 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2022; equivalent gene in S.pneumoniae R6 = spr1834; identified by match to protein family HMM PF02378; match to protein family HMM TIGR00410; PTS system transporter subunit IIC 1817703 4441325 SPD_1831 Streptococcus pneumoniae D39 PTS system transporter subunit IIC YP_817238.1 1816408 D 373153 CDS YP_817239.1 116515596 4442735 1817708..1818016 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2023; equivalent gene in S.pneumoniae R6 = spr1835; identified by match to protein family HMM PF02302; PTS system transporter subunit IIB 1818016 4442735 SPD_1832 Streptococcus pneumoniae D39 PTS system transporter subunit IIB YP_817239.1 1817708 D 373153 CDS YP_817240.1 116516943 4442019 1818013..1818321 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2024; equivalent gene in S.pneumoniae R6 = spr1836; identified by match to protein family HMM PF02255; PTS system transporter subunit IIA 1818321 4442019 SPD_1833 Streptococcus pneumoniae D39 PTS system transporter subunit IIA YP_817240.1 1818013 D 373153 CDS YP_817241.1 116515886 4441384 complement(1819229..1821880) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2026; equivalent gene in S.pneumoniae R6 = spr1837; identified by match to protein family HMM PF00465; bifunctional acetaldehyde-CoA/alcohol dehydrogenase 1821880 4441384 SPD_1834 Streptococcus pneumoniae D39 bifunctional acetaldehyde-CoA/alcohol dehydrogenase YP_817241.1 1819229 R 373153 CDS YP_817242.1 116517194 4441831 complement(1822083..1822220) 1 NC_008533.1 hypothetical protein 1822220 4441831 SPD_1835 Streptococcus pneumoniae D39 hypothetical protein YP_817242.1 1822083 R 373153 CDS YP_817243.1 116516602 4441232 complement(1822180..1822590) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2027; equivalent gene in S.pneumoniae R6 = spr1838; identified by match to protein family HMM PF02493; hypothetical protein 1822590 4441232 SPD_1836 Streptococcus pneumoniae D39 hypothetical protein YP_817243.1 1822180 R 373153 CDS YP_817244.1 116517142 4442380 complement(1822592..1823020) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2028; equivalent gene in S.pneumoniae R6 = spr1839; identified by match to protein family HMM PF01451; phosphotyrosine protein phosphatase 1823020 4442380 SPD_1837 Streptococcus pneumoniae D39 phosphotyrosine protein phosphatase YP_817244.1 1822592 R 373153 CDS YP_817245.1 116516333 4442816 complement(1823067..1823366) 1 NC_008533.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC 1823366 yajC 4442816 yajC Streptococcus pneumoniae D39 preprotein translocase subunit YajC YP_817245.1 1823067 R 373153 CDS YP_817246.1 116515729 4441017 complement(1823483..1825459) 1 NC_008533.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 1825459 tkt 4441017 tkt Streptococcus pneumoniae D39 transketolase YP_817246.1 1823483 R 373153 CDS YP_817247.1 116516032 4441692 complement(1825573..1826664) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2031; equivalent gene in S.pneumoniae R6 = spr1842; L-ascorbate 6-phosphate lactonase 1826664 4441692 SPD_1840 Streptococcus pneumoniae D39 L-ascorbate 6-phosphate lactonase YP_817247.1 1825573 R 373153 CDS YP_817248.1 116515617 4442697 complement(1826776..1828449) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2032; equivalent gene in S.pneumoniae R6 = spr1843; identified by match to protein family HMM PF00874; BglG family transcriptional regulator 1828449 4442697 SPD_1841 Streptococcus pneumoniae D39 BglG family transcriptional regulator YP_817248.1 1826776 R 373153 CDS YP_817249.1 116515625 4442705 complement(1828628..1829332) 1 NC_008533.1 catalyzes the formation of D-xylulose 5-phosphate from L-ribulose 5-phosphate in the L-arabinose and L-ascorbate degradation pathways; L-ribulose-5-phosphate 4-epimerase 1829332 araD 4442705 araD Streptococcus pneumoniae D39 L-ribulose-5-phosphate 4-epimerase YP_817249.1 1828628 R 373153 CDS YP_817250.1 116515477 4442647 complement(1829334..1830197) 1 NC_008533.1 L-xylulose 5-phosphate 3-epimerase activity not yet demonstrated; may be involved in the utilization of 2,3-diketo-L-gulonate; L-xylulose 5-phosphate 3-epimerase 1830197 4442647 SPD_1843 Streptococcus pneumoniae D39 L-xylulose 5-phosphate 3-epimerase YP_817250.1 1829334 R 373153 CDS YP_817251.1 116516297 4442586 complement(1830201..1830866) 1 NC_008533.1 catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization; 3-keto-L-gulonate-6-phosphate decarboxylase 1830866 ulaD 4442586 ulaD Streptococcus pneumoniae D39 3-keto-L-gulonate-6-phosphate decarboxylase YP_817251.1 1830201 R 373153 CDS YP_817252.1 116515791 4441556 complement(1830883..1831368) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2036; equivalent gene in S.pneumoniae R6 = spr1847; identified by match to protein family HMM PF00359; PTS system transporter subunit IIA 1831368 4441556 SPD_1845 Streptococcus pneumoniae D39 PTS system transporter subunit IIA YP_817252.1 1830883 R 373153 CDS YP_817253.1 116516606 4442383 complement(1831445..1831726) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2037; equivalent gene in S.pneumoniae R6 = spr1848; identified by match to protein family HMM PF02302; PTS system transporter subunit IIB 1831726 4442383 SPD_1846 Streptococcus pneumoniae D39 PTS system transporter subunit IIB YP_817253.1 1831445 R 373153 CDS YP_817254.1 116516701 4442327 complement(1831749..1833206) 1 NC_008533.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC 1833206 4442327 SPD_1847 Streptococcus pneumoniae D39 PTS system ascorbate-specific transporter subunit IIC YP_817254.1 1831749 R 373153 CDS YP_817255.1 116515843 4441534 complement(1833337..1833960) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2039; equivalent gene in S.pneumoniae R6 = spr1850; hypothetical protein 1833960 4441534 SPD_1848 Streptococcus pneumoniae D39 hypothetical protein YP_817255.1 1833337 R 373153 CDS YP_817256.1 116516984 4442004 complement(1834011..1834997) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2040; equivalent gene in S.pneumoniae R6 = spr1851; identified by match to protein family HMM PF01424; protein jag (SpoIIIJ-associated protein ) 1834997 4442004 SPD_1849 Streptococcus pneumoniae D39 protein jag (SpoIIIJ-associated protein ) YP_817256.1 1834011 R 373153 CDS YP_817257.1 116516129 4442217 complement(1835016..1835846) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2041; equivalent gene in S.pneumoniae R6 = spr1852; identified by match to protein family HMM PF02096; SpoIIIJ family protein 1835846 4442217 SPD_1850 Streptococcus pneumoniae D39 SpoIIIJ family protein YP_817257.1 1835016 R 373153 CDS YP_817258.1 116515893 4441391 complement(1835815..1836186) 1 NC_008533.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 1836186 rnpA 4441391 rnpA Streptococcus pneumoniae D39 ribonuclease P YP_817258.1 1835815 R 373153 CDS YP_817259.1 116516968 4442921 complement(1836203..1836334) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2043; hypothetical protein 1836334 4442921 SPD_1852 Streptococcus pneumoniae D39 hypothetical protein YP_817259.1 1836203 R 373153 CDS YP_817260.1 116515857 4441549 complement(1836335..1837525) 1 NC_008533.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 1837525 ackA 4441549 ackA Streptococcus pneumoniae D39 acetate kinase YP_817260.1 1836335 R 373153 CDS YP_817261.1 116516707 4442333 complement(1837576..1838529) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2045; equivalent gene in S.pneumoniae R6 = spr1855; hypothetical protein 1838529 4442333 SPD_1854 Streptococcus pneumoniae D39 hypothetical protein YP_817261.1 1837576 R 373153 CDS YP_817262.1 116515648 4441328 complement(1838590..1838970) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1856; hypothetical protein 1838970 4441328 SPD_1855 Streptococcus pneumoniae D39 hypothetical protein YP_817262.1 1838590 R 373153 CDS YP_817263.1 116516495 4443025 complement(1839002..1839184) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1857; hypothetical protein 1839184 4443025 SPD_1856 Streptococcus pneumoniae D39 hypothetical protein YP_817263.1 1839002 R 373153 CDS YP_817264.1 116515421 4442491 complement(1839321..1839734) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2047; equivalent gene in S.pneumoniae R6 = spr1858; hypothetical protein 1839734 4442491 SPD_1857 Streptococcus pneumoniae D39 hypothetical protein YP_817264.1 1839321 R 373153 CDS YP_817265.1 116516153 4442515 complement(1839712..1840173) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2048; equivalent gene in S.pneumoniae R6 = spr1859; hypothetical protein 1840173 4442515 SPD_1858 Streptococcus pneumoniae D39 hypothetical protein YP_817265.1 1839712 R 373153 CDS YP_817266.1 116516170 4442844 complement(1840136..1840396) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2049; hypothetical protein 1840396 4442844 SPD_1859 Streptococcus pneumoniae D39 hypothetical protein YP_817266.1 1840136 R 373153 CDS YP_817267.1 116516816 4442173 complement(1840401..1840805) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2050; equivalent gene in S.pneumoniae R6 = spr1861; identified by match to protein family HMM TIGR02532; competence protein CglD 1840805 clgD 4442173 clgD Streptococcus pneumoniae D39 competence protein CglD YP_817267.1 1840401 R 373153 CDS YP_817268.1 116515910 4442790 complement(1840798..1841124) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2051; equivalent gene in S.pneumoniae R6 = spr1862; identified by match to protein family HMM PF07963; match to protein family HMM TIGR02532; competence protein CglC 1841124 cglC 4442790 cglC Streptococcus pneumoniae D39 competence protein CglC YP_817268.1 1840798 R 373153 CDS YP_817269.1 116515992 4441495 complement(1841126..1841998) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2052; equivalent gene in S.pneumoniae R6 = spr1863; identified by match to protein family HMM PF00482; competence protein CglB 1841998 cglB 4441495 cglB Streptococcus pneumoniae D39 competence protein CglB YP_817269.1 1841126 R 373153 CDS YP_817270.1 116516783 4442236 complement(1842090..1843031) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2053; equivalent gene in S.pneumoniae R6 = spr1864; identified by match to protein family HMM PF00437; competence protein CglA 1843031 cglA 4442236 cglA Streptococcus pneumoniae D39 competence protein CglA YP_817270.1 1842090 R 373153 CDS YP_817271.1 116515909 4442789 complement(1843107..1843472) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2054; equivalent gene in S.pneumoniae R6 = spr1865; identified by match to protein family HMM PF06279; hypothetical protein 1843472 4442789 SPD_1864 Streptococcus pneumoniae D39 hypothetical protein YP_817271.1 1843107 R 373153 CDS YP_817272.1 116517097 4441908 complement(1843623..1844681) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2055; equivalent gene in S.pneumoniae R6 = spr1866; identified by match to protein family HMM PF00107; zinc-containing alcohol dehydrogenase 1844681 4441908 SPD_1865 Streptococcus pneumoniae D39 zinc-containing alcohol dehydrogenase YP_817272.1 1843623 R 373153 CDS YP_817273.1 116516233 4441513 complement(1844844..1845995) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2056; equivalent gene in S.pneumoniae R6 = spr1867; identified by match to protein family HMM PF01979; match to protein family HMM TIGR00221; N-acetylglucosamine-6-phosphate deacetylase 1845995 nagA 4441513 nagA Streptococcus pneumoniae D39 N-acetylglucosamine-6-phosphate deacetylase YP_817273.1 1844844 R 373153 CDS YP_817274.1 116516353 4442955 complement(1846148..1847965) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2057; equivalent gene in S.pneumoniae R6 = spr1868; identified by match to protein family HMM PF01757; hypothetical protein 1847965 4442955 SPD_1867 Streptococcus pneumoniae D39 hypothetical protein YP_817274.1 1846148 R 373153 CDS YP_817275.1 116515515 4442996 complement(1848063..1849205) 1 NC_008533.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase 1849205 tgt 4442996 tgt Streptococcus pneumoniae D39 queuine tRNA-ribosyltransferase YP_817275.1 1848063 R 373153 CDS YP_817276.1 116515894 4442773 1849335..1850192 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2059; equivalent gene in S.pneumoniae R6 = spr1870; identified by match to protein family HMM PF06161; hypothetical protein 1850192 4442773 SPD_1869 Streptococcus pneumoniae D39 hypothetical protein YP_817276.1 1849335 D 373153 CDS YP_817277.1 116517003 4441987 complement(1851003..1851302) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2061; equivalent gene in S.pneumoniae R6 = spr1873; identified by match to protein family HMM PF06993; hypothetical protein 1851302 4441987 SPD_1871 Streptococcus pneumoniae D39 hypothetical protein YP_817277.1 1851003 R 373153 CDS YP_817278.1 116515344 4441086 complement(1851734..1851847) 1 NC_008533.1 hypothetical protein 1851847 4441086 SPD_1873 Streptococcus pneumoniae D39 hypothetical protein YP_817278.1 1851734 R 373153 CDS YP_817279.1 116515770 4441670 complement(1852057..1853199) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2063; equivalent gene in S.pneumoniae R6 = spr1875; identified by match to protein family HMM PF01476; LysM domain-containing protein 1853199 4441670 SPD_1874 Streptococcus pneumoniae D39 LysM domain-containing protein YP_817279.1 1852057 R 373153 CDS YP_817280.1 116516634 4441423 complement(1853365..1853985) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2064; equivalent gene in S.pneumoniae R6 = spr1876; identified by match to protein family HMM PF00702; match to protein family HMM TIGR01549; hydrolase 1853985 4441423 SPD_1875 Streptococcus pneumoniae D39 hydrolase YP_817280.1 1853365 R 373153 CDS YP_817281.1 116515917 4441060 complement(1853989..1855269) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2065; equivalent gene in S.pneumoniae R6 = spr1877; identified by match to protein family HMM PF01554; match to protein family HMM TIGR00797; MATE efflux family protein 1855269 4441060 SPD_1876 Streptococcus pneumoniae D39 MATE efflux family protein YP_817281.1 1853989 R 373153 CDS YP_817282.1 116516763 4442274 complement(1855330..1856814) 1 NC_008533.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 1856814 thrC 4442274 thrC Streptococcus pneumoniae D39 threonine synthase YP_817282.1 1855330 R 373153 CDS YP_817283.1 116515452 4441176 complement(1856890..1858167) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2067; equivalent gene in S.pneumoniae R6 = spr1879; hypothetical protein 1858167 4441176 SPD_1878 Streptococcus pneumoniae D39 hypothetical protein YP_817283.1 1856890 R 373153 CDS YP_817284.1 116515341 4441083 complement(1864631..1865065) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2068; equivalent gene in S.pneumoniae R6 = spr1880; identified by match to protein family HMM PF00383; cytidine/deoxycytidylate deaminase family protein 1865065 4441083 SPD_1895 Streptococcus pneumoniae D39 cytidine/deoxycytidylate deaminase family protein YP_817284.1 1864631 R 373153 CDS YP_817285.1 116516946 4442022 complement(1865079..1866539) 1 NC_008533.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 1866539 gltX 4442022 gltX Streptococcus pneumoniae D39 glutamyl-tRNA synthetase YP_817285.1 1865079 R 373153 CDS YP_817286.1 116516610 4442387 complement(1866663..1868012) 1 NC_008533.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 1868012 pgi 4442387 pgi Streptococcus pneumoniae D39 glucose-6-phosphate isomerase YP_817286.1 1866663 R 373153 CDS YP_817287.1 116516772 4442283 complement(1867999..1868178) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2071; equivalent gene in S.pneumoniae R6 = spr1883; hypothetical protein 1868178 4442283 SPD_1898 Streptococcus pneumoniae D39 hypothetical protein YP_817287.1 1867999 R 373153 CDS YP_817288.1 116516367 4443029 complement(1868182..1868910) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2072; equivalent gene in S.pneumoniae R6 = spr1884; identified by match to protein family HMM PF00117; match to protein family HMM PF07722; glutamine amidotransferase, class 1 1868910 4443029 SPD_1899 Streptococcus pneumoniae D39 glutamine amidotransferase, class 1 YP_817288.1 1868182 R 373153 CDS YP_817289.1 116515530 4442895 complement(1869010..1870776) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2073; equivalent gene in S.pneumoniae R6 = spr1885; identified by match to protein family HMM PF00005; match to protein family HMM PF00664; ABC transporter ATP-binding protein/permease 1870776 4442895 SPD_1900 Streptococcus pneumoniae D39 ABC transporter ATP-binding protein/permease YP_817289.1 1869010 R 373153 CDS YP_817290.1 116516118 4441643 1871024..1871233 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1886; transposase 1871233 4441643 SPD_1901 Streptococcus pneumoniae D39 transposase YP_817290.1 1871024 D 373153 CDS YP_817291.1 116517181 4441857 complement(1871563..1873257) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2075; equivalent gene in S.pneumoniae R6 = spr1887; identified by match to protein family HMM PF00005; match to protein family HMM PF00664; ABC transporter ATP-binding protein/permease 1873257 4441857 SPD_1902 Streptococcus pneumoniae D39 ABC transporter ATP-binding protein/permease YP_817291.1 1871563 R 373153 CDS YP_817292.1 116515831 4441122 complement(1873404..1875938) 1 NC_008533.1 This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS 1875938 mutS 4441122 mutS Streptococcus pneumoniae D39 DNA mismatch repair protein MutS YP_817292.1 1873404 R 373153 CDS YP_817293.1 116516959 4442912 complement(1875989..1876435) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2077; equivalent gene in S.pneumoniae R6 = spr1889; identified by match to protein family HMM PF01316; match to protein family HMM PF02863; match to protein family HMM TIGR01529; arginine repressor 1876435 argR 4442912 argR Streptococcus pneumoniae D39 arginine repressor YP_817293.1 1875989 R 373153 CDS YP_817294.1 116516539 4441042 1876583..1878274 1 NC_008533.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 1878274 argS 4441042 argS Streptococcus pneumoniae D39 arginyl-tRNA synthetase YP_817294.1 1876583 D 373153 CDS YP_817295.1 116516479 4443008 complement(1878589..1878978) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1086; equivalent gene in S.pneumoniae R6 = spr1891; identified by match to protein family HMM PF01609; IS1381, transposase OrfB 1878978 4443008 SPD_1906 Streptococcus pneumoniae D39 IS1381, transposase OrfB YP_817295.1 1878589 R 373153 CDS YP_817296.1 116515391 4442461 1879142..1879618 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2081; equivalent gene in S.pneumoniae R6 = spr1892; identified by match to protein family HMM PF06172; hypothetical protein 1879618 4442461 SPD_1907 Streptococcus pneumoniae D39 hypothetical protein YP_817296.1 1879142 D 373153 CDS YP_817297.1 116516111 4441636 1879702..1880409 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2082; equivalent gene in S.pneumoniae R6 = spr1893; identified by match to protein family HMM PF00072; match to protein family HMM PF00486; response regulator 1880409 4441636 SPD_1908 Streptococcus pneumoniae D39 response regulator YP_817297.1 1879702 D 373153 CDS YP_817298.1 116515950 4441352 1880410..1881741 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2083; equivalent gene in S.pneumoniae R6 = spr1894; identified by match to protein family HMM PF00512; match to protein family HMM PF02518; sensor histidine kinase PnpS 1881741 pnpS 4441352 pnpS Streptococcus pneumoniae D39 sensor histidine kinase PnpS YP_817298.1 1880410 D 373153 CDS YP_817299.1 116516790 4442243 1881908..1882783 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2084; equivalent gene in S.pneumoniae R6 = spr1895; phosphate ABC transporter substrate-binding protein 1882783 pstS 4442243 pstS Streptococcus pneumoniae D39 phosphate ABC transporter substrate-binding protein YP_817299.1 1881908 D 373153 CDS YP_817300.1 116515718 4442256 1882901..1883764 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2085; equivalent gene in S.pneumoniae R6 = spr1896; identified by match to protein family HMM PF00528; match to protein family HMM TIGR02138; phosphate ABC transporter permease 1883764 pstC 4442256 pstC Streptococcus pneumoniae D39 phosphate ABC transporter permease YP_817300.1 1882901 D 373153 CDS YP_817301.1 116516568 4441273 1883757..1884572 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2086; equivalent gene in S.pneumoniae R6 = spr1897; identified by match to protein family HMM PF00528; match to protein family HMM TIGR00974; phosphate ABC transporter permease 1884572 pstA 4441273 pstA Streptococcus pneumoniae D39 phosphate ABC transporter permease YP_817301.1 1883757 D 373153 CDS YP_817302.1 116516574 4442095 1884574..1885326 1 NC_008533.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein 1885326 pstB 4442095 pstB Streptococcus pneumoniae D39 phosphate transporter ATP-binding protein YP_817302.1 1884574 D 373153 CDS YP_817303.1 116515544 4442718 1885341..1885991 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2088; equivalent gene in S.pneumoniae R6 = spr1899; identified by match to protein family HMM PF01895; match to protein family HMM TIGR02135; phosphate transport system regulatory protein PhoU 1885991 phoU 4442718 phoU Streptococcus pneumoniae D39 phosphate transport system regulatory protein PhoU YP_817303.1 1885341 D 373153 CDS YP_817304.1 116517050 4441938 complement(1886598..1887038) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2090; equivalent gene in S.pneumoniae R6 = spr1901; identified by match to protein family HMM PF01381; transcriptional regulator 1887038 4441938 SPD_1916 Streptococcus pneumoniae D39 transcriptional regulator YP_817304.1 1886598 R 373153 CDS YP_817305.1 116516288 4442616 complement(1887129..1887251) 1 NC_008533.1 hypothetical protein 1887251 4442616 SPD_1917 Streptococcus pneumoniae D39 hypothetical protein YP_817305.1 1887129 R 373153 CDS YP_817306.1 116516995 4441977 1887250..1888266 1 NC_008533.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 1888266 gpsA 4441977 gpsA Streptococcus pneumoniae D39 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase YP_817306.1 1887250 D 373153 CDS YP_817307.1 116516192 4441150 1888288..1889187 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2092; equivalent gene in S.pneumoniae R6 = spr1903; identified by match to protein family HMM PF00483; match to protein family HMM TIGR01099; UTP-glucose-1-phosphate uridylyltransferase 1889187 galU 4441150 galU Streptococcus pneumoniae D39 UTP-glucose-1-phosphate uridylyltransferase YP_817307.1 1888288 D 373153 CDS YP_817308.1 116516863 4442145 complement(1889254..1889931) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2094; equivalent gene in S.pneumoniae R6 = spr1904; identified by match to protein family HMM PF01694; hypothetical protein 1889931 4442145 SPD_1920 Streptococcus pneumoniae D39 hypothetical protein YP_817308.1 1889254 R 373153 CDS YP_817309.1 116515920 4441063 complement(1889915..1890454) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2095; equivalent gene in S.pneumoniae R6 = spr1905; identified by match to protein family HMM PF01812; match to protein family HMM TIGR02727; 5-formyltetrahydrofolate cyclo-ligase 1890454 4441063 SPD_1921 Streptococcus pneumoniae D39 5-formyltetrahydrofolate cyclo-ligase YP_817309.1 1889915 R 373153 CDS YP_817310.1 116515584 4441204 complement(1890466..1891596) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2096; equivalent gene in S.pneumoniae R6 = spr1906; identified by match to protein family HMM PF01546; match to protein family HMM PF07687; match to protein family HMM TIGR01891; peptidase, M20/M25/M40 family protein 1891596 4441204 SPD_1922 Streptococcus pneumoniae D39 peptidase, M20/M25/M40 family protein YP_817310.1 1890466 R 373153 CDS YP_817311.1 116516648 4443052 complement(1891664..1892362) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2097; equivalent gene in S.pneumoniae R6 = spr1907; identified by match to protein family HMM PF00132; 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase 1892362 4443052 SPD_1923 Streptococcus pneumoniae D39 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase YP_817311.1 1891664 R 373153 CDS YP_817312.1 116515670 4441253 complement(1892592..1893503) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2098; equivalent gene in S.pneumoniae R6 = spr1908; identified by match to protein family HMM PF00892; hypothetical protein 1893503 4441253 SPD_1924 Streptococcus pneumoniae D39 hypothetical protein YP_817312.1 1892592 R 373153 CDS YP_817313.1 116516492 4443022 complement(1893568..1896033) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2099; equivalent gene in S.pneumoniae R6 = spr1909; identified by match to protein family HMM PF00905; match to protein family HMM PF00912; penicillin-binding protein 1B 1896033 pbp1B 4443022 pbp1B Streptococcus pneumoniae D39 penicillin-binding protein 1B YP_817313.1 1893568 R 373153 CDS YP_817314.1 116516055 4442764 1896175..1897431 1 NC_008533.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 1897431 tyrS 4442764 tyrS Streptococcus pneumoniae D39 tyrosyl-tRNA synthetase YP_817314.1 1896175 D 373153 CDS YP_817315.1 116517091 4441902 complement(1897509..1899572) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2101; equivalent gene in S.pneumoniae R6 = spr1911; identified by match to protein family HMM PF00122; match to protein family HMM PF00702; match to protein family HMM TIGR01494; match to protein family HMM TIGR01512; match to protein family HMM TIGR01525; cation-transporting ATPase, E1-E2 family protein 1899572 4441902 SPD_1927 Streptococcus pneumoniae D39 cation-transporting ATPase, E1-E2 family protein YP_817315.1 1897509 R 373153 CDS YP_817316.1 116515549 4442723 complement(1899574..1899885) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2102; equivalent gene in S.pneumoniae R6 = spr1912; hypothetical protein 1899885 4442723 SPD_1928 Streptococcus pneumoniae D39 hypothetical protein YP_817316.1 1899574 R 373153 CDS YP_817317.1 116516682 4441356 1900004..1900852 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2103; equivalent gene in S.pneumoniae R6 = spr1913; rRNA (guanine-N1-)-methyltransferase 1900852 rrmA 4441356 rrmA Streptococcus pneumoniae D39 rRNA (guanine-N1-)-methyltransferase YP_817317.1 1900004 D 373153 CDS YP_817318.1 116516684 4441358 complement(1901368..1901574) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2104; equivalent gene in S.pneumoniae R6 = spr1914; hypothetical protein 1901574 4441358 SPD_1930 Streptococcus pneumoniae D39 hypothetical protein YP_817318.1 1901368 R 373153 CDS YP_817319.1 116515564 4442874 1901651..1902223 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2105; equivalent gene in S.pneumoniae R6 = spr1915; hypothetical protein 1902223 4442874 SPD_1931 Streptococcus pneumoniae D39 hypothetical protein YP_817319.1 1901651 D 373153 CDS YP_817320.1 116515958 4441399 complement(1903268..1905526) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2106; equivalent gene in S.pneumoniae R6 = spr1916; identified by match to protein family HMM PF00343; match to protein family HMM TIGR02093; maltodextrin phosphorylase 1905526 malP 4441399 malP Streptococcus pneumoniae D39 maltodextrin phosphorylase YP_817320.1 1903268 R 373153 CDS YP_817321.1 116516849 4442130 complement(1905552..1907069) 1 NC_008533.1 amylomaltase; acts to release glucose from maltodextrins; 4-alpha-glucanotransferase 1907069 malQ 4442130 malQ Streptococcus pneumoniae D39 4-alpha-glucanotransferase YP_817321.1 1905552 R 373153 CDS YP_817322.1 116517172 4441847 1907619..1908890 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2108; equivalent gene in S.pneumoniae R6 = spr1918; identified by match to protein family HMM PF01547; maltose/maltodextrin ABC transporter maltose/maltodextrin-binding protein 1908890 malX 4441847 malX Streptococcus pneumoniae D39 maltose/maltodextrin ABC transporter maltose/maltodextrin-binding protein YP_817322.1 1907619 D 373153 CDS YP_817323.1 116515389 4441625 1909001..1910293 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2109; equivalent gene in S.pneumoniae R6 = spr1919; identified by match to protein family HMM PF00528; match to protein family HMM PF05154; maltodextrin ABC transporter permease 1910293 malC 4441625 malC Streptococcus pneumoniae D39 maltodextrin ABC transporter permease YP_817323.1 1909001 D 373153 CDS YP_817324.1 116517158 4441872 1910295..1911137 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2110; equivalent gene in S.pneumoniae R6 = spr1920; identified by match to protein family HMM PF00528; maltodextrin ABC transporter permease 1911137 malD 4441872 malD Streptococcus pneumoniae D39 maltodextrin ABC transporter permease YP_817324.1 1910295 D 373153 CDS YP_817325.1 116516009 4441571 1911390..1912190 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2111; equivalent gene in S.pneumoniae R6 = spr1921; maltodextrose utilization protein MalA 1912190 malA 4441571 malA Streptococcus pneumoniae D39 maltodextrose utilization protein MalA YP_817325.1 1911390 D 373153 CDS YP_817326.1 116516891 4442076 1912200..1913186 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2112; equivalent gene in S.pneumoniae R6 = spr1922; identified by match to protein family HMM PF00356; match to protein family HMM PF00532; maltose operon transcriptional repressor 1913186 malR 4442076 malR Streptococcus pneumoniae D39 maltose operon transcriptional repressor YP_817326.1 1912200 D 373153 CDS YP_817327.1 116515796 4441561 1913253..1913474 1 NC_008533.1 hypothetical protein 1913474 4441561 SPD_1939 Streptococcus pneumoniae D39 hypothetical protein YP_817327.1 1913253 D 373153 CDS YP_817328.1 116517145 4441858 complement(1913478..1914419) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2113; equivalent gene in S.pneumoniae R6 = spr1923; identified by match to protein family HMM PF02588; hypothetical protein 1914419 4441858 SPD_1940 Streptococcus pneumoniae D39 hypothetical protein YP_817328.1 1913478 R 373153 CDS YP_817329.1 116516137 4442499 complement(1914397..1916160) 1 NC_008533.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase 1916160 aspS 4442499 aspS Streptococcus pneumoniae D39 aspartyl-tRNA synthetase YP_817329.1 1914397 R 373153 CDS YP_817330.1 116516424 4441650 complement(1916279..1916470) 1 NC_008533.1 hypothetical protein 1916470 4441650 SPD_1942 Streptococcus pneumoniae D39 hypothetical protein YP_817330.1 1916279 R 373153 CDS YP_817331.1 116515350 4441092 complement(1916512..1916742) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2115; equivalent gene in S.pneumoniae R6 = spr1925; hypothetical protein 1916742 4441092 SPD_1943 Streptococcus pneumoniae D39 hypothetical protein YP_817331.1 1916512 R 373153 CDS YP_817332.1 116516646 4443050 complement(1916760..1917401) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2116; equivalent gene in S.pneumoniae R6 = spr1926; identified by match to protein family HMM PF02517; hypothetical protein 1917401 4443050 SPD_1944 Streptococcus pneumoniae D39 hypothetical protein YP_817332.1 1916760 R 373153 CDS YP_817333.1 116515612 4442751 complement(1917413..1918147) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2117; equivalent gene in S.pneumoniae R6 = spr1927; hypothetical protein 1918147 4442751 SPD_1945 Streptococcus pneumoniae D39 hypothetical protein YP_817333.1 1917413 R 373153 CDS YP_817334.1 116517007 4441991 complement(1918150..1918347) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2118; equivalent gene in S.pneumoniae R6 = spr1928; hypothetical protein 1918347 4441991 SPD_1946 Streptococcus pneumoniae D39 hypothetical protein YP_817334.1 1918150 R 373153 CDS YP_817335.1 116516030 4441690 complement(1918347..1918553) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2119; equivalent gene in S.pneumoniae R6 = spr1929; identified by match to protein family HMM PF01381; transcriptional regulator 1918553 4441690 SPD_1947 Streptococcus pneumoniae D39 transcriptional regulator YP_817335.1 1918347 R 373153 CDS YP_817336.1 116515313 4442656 complement(1918563..1919027) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1930; hypothetical protein 1919027 4442656 SPD_1948 Streptococcus pneumoniae D39 hypothetical protein YP_817336.1 1918563 R 373153 CDS YP_817337.1 116516373 4443035 complement(1919027..1919206) 1 NC_008533.1 hypothetical protein 1919206 4443035 SPD_1949 Streptococcus pneumoniae D39 hypothetical protein YP_817337.1 1919027 R 373153 CDS YP_817338.1 116515787 4441552 complement(1919203..1920492) 1 NC_008533.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase 1920492 hisS 4441552 hisS Streptococcus pneumoniae D39 histidyl-tRNA synthetase YP_817338.1 1919203 R 373153 CDS YP_817339.1 116516587 4441216 complement(1920570..1921817) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2122; equivalent gene in S.pneumoniae R6 = spr1932; identified by match to protein family HMM PF07690; hypothetical protein 1921817 4441216 SPD_1951 Streptococcus pneumoniae D39 hypothetical protein YP_817339.1 1920570 R 373153 CDS YP_817340.1 116515929 4441072 complement(1922007..1922858) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1933; identified by match to protein family HMM TIGR01716; transcriptional activator Rgg/GadR/MutR family protein 1922858 4441072 SPD_1952 Streptococcus pneumoniae D39 transcriptional activator Rgg/GadR/MutR family protein YP_817340.1 1922007 R 373153 CDS YP_817341.1 116516794 4442189 complement(1922833..1922967) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2124; hypothetical protein 1922967 4442189 SPD_1953 Streptococcus pneumoniae D39 hypothetical protein YP_817341.1 1922833 R 373153 CDS YP_817342.1 116516133 4442223 1922982..1923323 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2125; equivalent gene in S.pneumoniae R6 = spr1934; identified by match to protein family HMM PF01883; hypothetical protein 1923323 4442223 SPD_1954 Streptococcus pneumoniae D39 hypothetical protein YP_817342.1 1922982 D 373153 CDS YP_817343.1 116516770 4442281 1923387..1923506 1 NC_008533.1 hypothetical protein 1923506 4442281 SPD_1955 Streptococcus pneumoniae D39 hypothetical protein YP_817343.1 1923387 D 373153 CDS YP_817344.1 116516565 4441270 complement(1923532..1925235) 1 NC_008533.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase 1925235 ilvD 4441270 ilvD Streptococcus pneumoniae D39 dihydroxy-acid dehydratase YP_817344.1 1923532 R 373153 CDS YP_817345.1 116515375 4441610 complement(1925468..1926400) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2127; equivalent gene in S.pneumoniae R6 = spr1936; identified by match to protein family HMM PF02779; match to protein family HMM PF02780; transketolase, C-terminal subunit 1926400 4441610 SPD_1957 Streptococcus pneumoniae D39 transketolase, C-terminal subunit YP_817345.1 1925468 R 373153 CDS YP_817346.1 116515337 4441079 complement(1926397..1927254) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2128; equivalent gene in S.pneumoniae R6 = spr1937; identified by match to protein family HMM PF00456; transketolase 1927254 4441079 SPD_1958 Streptococcus pneumoniae D39 transketolase YP_817346.1 1926397 R 373153 CDS YP_817347.1 116516643 4443047 complement(1927258..1928604) 1 NC_008533.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC 1928604 ulaA 4443047 ulaA Streptococcus pneumoniae D39 PTS system ascorbate-specific transporter subunit IIC YP_817347.1 1927258 R 373153 CDS YP_817348.1 116516056 4442765 complement(1928617..1928901) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2130; equivalent gene in S.pneumoniae R6 = spr1939; identified by match to protein family HMM PF02302; PTS system transporter subunit IIB 1928901 4442765 SPD_1960 Streptococcus pneumoniae D39 PTS system transporter subunit IIB YP_817348.1 1928617 R 373153 CDS YP_817349.1 116516429 4441655 complement(1928905..1930935) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2131; equivalent gene in S.pneumoniae R6 = spr1940; identified by match to protein family HMM PF00359; match to protein family HMM PF00874; BglG family transcriptional regulator 1930935 4441655 SPD_1961 Streptococcus pneumoniae D39 BglG family transcriptional regulator YP_817349.1 1928905 R 373153 CDS YP_817350.1 116517201 4441838 1931126..1932133 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2132; equivalent gene in S.pneumoniae R6 = spr1941; identified by match to protein family HMM PF01145; hypothetical protein 1932133 4441838 SPD_1962 Streptococcus pneumoniae D39 hypothetical protein YP_817350.1 1931126 D 373153 CDS YP_817351.1 116516063 4442772 1932488..1932670 1 NC_008533.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 1932670 rpmF 4442772 rpmF Streptococcus pneumoniae D39 50S ribosomal protein L32 YP_817351.1 1932488 D 373153 CDS YP_817352.1 116516908 4442056 1932686..1932835 1 NC_008533.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 1932835 rpmG 4442056 rpmG Streptococcus pneumoniae D39 50S ribosomal protein L33 YP_817352.1 1932686 D 373153 CDS YP_817353.1 116515800 4441565 complement(1933315..1935357) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2136; equivalent gene in S.pneumoniae R6 = spr1945; identified by match to protein family HMM PF01473; choline binding protein PcpA 1935357 pcpA 4441565 pcpA Streptococcus pneumoniae D39 choline binding protein PcpA YP_817353.1 1933315 R 373153 CDS YP_817354.1 116516391 4441597 1935714..1936283 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP0537; equivalent gene in S.pneumoniae R6 = spr1946; identified by match to protein family HMM PF04326; IS1381, transposase OrfA 1936283 4441597 SPD_1966 Streptococcus pneumoniae D39 IS1381, transposase OrfA YP_817354.1 1935714 D 373153 CDS YP_817355.1 116515349 4441091 1936309..1936698 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP1086; equivalent gene in S.pneumoniae R6 = spr1947; identified by match to protein family HMM PF01609; IS1381, transposase OrfB 1936698 4441091 SPD_1967 Streptococcus pneumoniae D39 IS1381, transposase OrfB YP_817355.1 1936309 D 373153 CDS YP_817356.1 116516408 4442974 complement(1936750..1937076) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2139; equivalent gene in S.pneumoniae R6 = spr1948; hypothetical protein 1937076 4442974 SPD_1968 Streptococcus pneumoniae D39 hypothetical protein YP_817356.1 1936750 R 373153 CDS YP_817357.1 116515878 4441375 complement(1937402..1939282) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2141; equivalent gene in S.pneumoniae R6 = spr1949; identified by match to protein family HMM PF00728; glycosyl hydrolase-like protein 1939282 4441375 SPD_1969 Streptococcus pneumoniae D39 glycosyl hydrolase-like protein YP_817357.1 1937402 R 373153 CDS YP_817358.1 116516983 4442003 complement(1939276..1940145) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2142; equivalent gene in S.pneumoniae R6 = spr1950; identified by match to protein family HMM PF00480; ROK family protein 1940145 4442003 SPD_1970 Streptococcus pneumoniae D39 ROK family protein YP_817358.1 1939276 R 373153 CDS YP_817359.1 116516168 4442842 complement(1940229..1942874) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2143; equivalent gene in S.pneumoniae R6 = spr1951; identified by match to protein family HMM PF01074; match to protein family HMM PF07748; hypothetical protein 1942874 4442842 SPD_1971 Streptococcus pneumoniae D39 hypothetical protein YP_817359.1 1940229 R 373153 CDS YP_817360.1 116517029 4441974 complement(1942965..1944245) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2144; equivalent gene in S.pneumoniae R6 = spr1952; identified by match to protein family HMM PF06824; hypothetical protein 1944245 4441974 SPD_1972 Streptococcus pneumoniae D39 hypothetical protein YP_817360.1 1942965 R 373153 CDS YP_817361.1 116515902 4442782 1944416..1946500 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2145; equivalent gene in S.pneumoniae R6 = spr1953; identified by match to protein family HMM PF07971; match to protein family HMM TIGR01180; alpha-1,2-mannosidase 1946500 4442782 SPD_1973 Streptococcus pneumoniae D39 alpha-1,2-mannosidase YP_817361.1 1944416 D 373153 CDS YP_817362.1 116516956 4442909 complement(1946540..1948219) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2146; equivalent gene in S.pneumoniae R6 = spr1954; identified by match to protein family HMM PF00754; hypothetical protein 1948219 4442909 SPD_1974 Streptococcus pneumoniae D39 hypothetical protein YP_817362.1 1946540 R 373153 CDS YP_817363.1 116516173 4442847 1950271..1951287 1 NC_008533.1 catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway; ornithine carbamoyltransferase 1951287 argF 4442847 argF Streptococcus pneumoniae D39 ornithine carbamoyltransferase YP_817363.1 1950271 D 373153 CDS YP_817364.1 116517200 4441837 1951452..1952399 1 NC_008533.1 catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase 1952399 arcC 4441837 arcC Streptococcus pneumoniae D39 carbamate kinase YP_817364.1 1951452 D 373153 CDS YP_817365.1 116516100 4442694 1952608..1954119 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2152; equivalent gene in S.pneumoniae R6 = spr1959; identified by match to protein family HMM PF03606; hypothetical protein 1954119 4442694 SPD_1978 Streptococcus pneumoniae D39 hypothetical protein YP_817365.1 1952608 D 373153 CDS YP_817366.1 116516441 4442560 1954141..1955472 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2153; equivalent gene in S.pneumoniae R6 = spr1960; identified by match to protein family HMM PF01546; match to protein family HMM TIGR01887; hypothetical protein 1955472 4442560 SPD_1979 Streptococcus pneumoniae D39 hypothetical protein YP_817366.1 1954141 D 373153 CDS YP_817367.1 116516541 4441044 complement(1955877..1956167) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1961; hypothetical protein 1956167 4441044 SPD_1981 Streptococcus pneumoniae D39 hypothetical protein YP_817367.1 1955877 R 373153 CDS YP_817368.1 116516901 4442086 complement(1956155..1956304) 1 NC_008533.1 hypothetical protein 1956304 4442086 SPD_1982 Streptococcus pneumoniae D39 hypothetical protein YP_817368.1 1956155 R 373153 CDS YP_817369.1 116515824 4441115 1956590..1956769 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1214; hypothetical protein 1956769 4441115 SPD_1983 Streptococcus pneumoniae D39 hypothetical protein YP_817369.1 1956590 D 373153 CDS YP_817370.1 116516677 4442458 complement(1956806..1957705) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2156; equivalent gene in S.pneumoniae R6 = spr1962; identified by match to protein family HMM PF01145; hypersensitive-induced reaction protein 4 1957705 4442458 SPD_1984 Streptococcus pneumoniae D39 hypersensitive-induced reaction protein 4 YP_817370.1 1956806 R 373153 CDS YP_817371.1 116515561 4442871 complement(1957835..1958986) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2157; equivalent gene in S.pneumoniae R6 = spr1963; identified by match to protein family HMM PF00465; iron-containing alcohol dehydrogenase 1958986 4442871 SPD_1985 Streptococcus pneumoniae D39 iron-containing alcohol dehydrogenase YP_817371.1 1957835 R 373153 CDS YP_817372.1 116516456 4442576 complement(1959132..1960898) 1 NC_008533.1 catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose; L-fucose isomerase 1960898 fucI 4442576 fucI Streptococcus pneumoniae D39 L-fucose isomerase YP_817372.1 1959132 R 373153 CDS YP_817373.1 116515536 4442901 complement(1960955..1964071) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2159; equivalent gene in S.pneumoniae R6 = spr1965; identified by match to protein family HMM PF00754; fucolectin-like protein 1964071 4442901 SPD_1987 Streptococcus pneumoniae D39 fucolectin-like protein YP_817373.1 1960955 R 373153 CDS YP_817374.1 116517212 4441810 complement(1964081..1966375) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2160; equivalent gene in S.pneumoniae R6 = spr1966; hypothetical protein 1966375 4441810 SPD_1988 Streptococcus pneumoniae D39 hypothetical protein YP_817374.1 1964081 R 373153 CDS YP_817375.1 116516146 4442508 complement(1966434..1967234) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2161; equivalent gene in S.pneumoniae R6 = spr1967; identified by match to protein family HMM PF03613; PTS system transporter subunit IID 1967234 4442508 SPD_1989 Streptococcus pneumoniae D39 PTS system transporter subunit IID YP_817375.1 1966434 R 373153 CDS YP_817376.1 116516971 4442924 complement(1967231..1968004) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2162; equivalent gene in S.pneumoniae R6 = spr1968; identified by match to protein family HMM PF03609; PTS system transporter subunit IIC 1968004 4442924 SPD_1990 Streptococcus pneumoniae D39 PTS system transporter subunit IIC YP_817376.1 1967231 R 373153 CDS YP_817377.1 116515959 4441400 complement(1968029..1968499) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2163; equivalent gene in S.pneumoniae R6 = spr1969; identified by match to protein family HMM PF03830; PTS system transporter subunit IIB 1968499 4441400 SPD_1991 Streptococcus pneumoniae D39 PTS system transporter subunit IIB YP_817377.1 1968029 R 373153 CDS YP_817378.1 116517183 4441820 complement(1968490..1968933) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2164; equivalent gene in S.pneumoniae R6 = spr1970; identified by match to protein family HMM PF03610; PTS system transporter subunit IIA 1968933 4441820 SPD_1992 Streptococcus pneumoniae D39 PTS system transporter subunit IIA YP_817378.1 1968490 R 373153 CDS YP_817379.1 116516128 4442216 complement(1968914..1969354) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2165; equivalent gene in S.pneumoniae R6 = spr1971; identified by match to protein family HMM PF05025; RbsD/FucU transport protein family protein 1969354 fucU 4442216 fucU Streptococcus pneumoniae D39 RbsD/FucU transport protein family protein YP_817379.1 1968914 R 373153 CDS YP_817380.1 116516769 4442280 complement(1969366..1970004) 1 NC_008533.1 catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate; L-fuculose phosphate aldolase 1970004 fucA 4442280 fucA Streptococcus pneumoniae D39 L-fuculose phosphate aldolase YP_817380.1 1969366 R 373153 CDS YP_817381.1 116516651 4443055 complement(1970119..1971522) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2167; equivalent gene in S.pneumoniae R6 = spr1973; identified by match to protein family HMM PF00370; match to protein family HMM PF02782; L-fuculose kinase 1971522 fucK 4443055 fucK Streptococcus pneumoniae D39 L-fuculose kinase YP_817381.1 1970119 R 373153 CDS YP_817382.1 116517134 4442372 1971698..1972471 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2168; equivalent gene in S.pneumoniae R6 = spr1974; identified by match to protein family HMM PF00455; match to protein family HMM PF08220; fucose operon repressor 1972471 4442372 SPD_1996 Streptococcus pneumoniae D39 fucose operon repressor YP_817382.1 1971698 D 373153 CDS YP_817383.1 116516060 4442769 complement(1973600..1975105) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2169; equivalent gene in S.pneumoniae R6 = spr1975; identified by match to protein family HMM PF01297; zinc ABC transporter zinc-binding lipoprotein 1975105 adcA 4442769 adcA Streptococcus pneumoniae D39 zinc ABC transporter zinc-binding lipoprotein YP_817383.1 1973600 R 373153 CDS YP_817384.1 116516369 4443031 complement(1975115..1975921) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2170; equivalent gene in S.pneumoniae R6 = spr1976; identified by match to protein family HMM PF00950; zinc ABC transporter permease 1975921 adcB 4443031 adcB Streptococcus pneumoniae D39 zinc ABC transporter permease YP_817384.1 1975115 R 373153 CDS YP_817385.1 116516242 4441522 complement(1975914..1976618) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2171; equivalent gene in S.pneumoniae R6 = spr1977; identified by match to protein family HMM PF00005; zinc ABC transporter ATP-binding protein 1976618 adcC 4441522 adcC Streptococcus pneumoniae D39 zinc ABC transporter ATP-binding protein YP_817385.1 1975914 R 373153 CDS YP_817386.1 116516635 4441424 complement(1976618..1977058) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2172; equivalent gene in S.pneumoniae R6 = spr1978; identified by match to protein family HMM PF01022; match to protein family HMM PF01047; match to protein family HMM PF01325; match to protein family HMM PF01978; adc operon repressor AdcR 1977058 adcR 4441424 adcR Streptococcus pneumoniae D39 adc operon repressor AdcR YP_817386.1 1976618 R 373153 CDS YP_817387.1 116515569 4442879 1977043..1977180 1 NC_008533.1 hypothetical protein 1977180 4442879 SPD_2001 Streptococcus pneumoniae D39 hypothetical protein YP_817387.1 1977043 D 373153 CDS YP_817388.1 116515941 4441343 complement(1977213..1978481) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2173; equivalent gene in S.pneumoniae R6 = spr1979; identified by match to protein family HMM PF04914; match to protein family HMM PF04915; match to protein family HMM PF04918; undecaprenol-phosphate-poly(glycerophosphate subunit) D-alanine transfer protein 1978481 dltD 4441343 dltD Streptococcus pneumoniae D39 undecaprenol-phosphate-poly(glycerophosphate subunit) D-alanine transfer protein YP_817388.1 1977213 R 373153 CDS YP_817389.1 116516809 4442205 complement(1978474..1978713) 1 NC_008533.1 D-alanyl carrier protein subunit; involved in the incorporation of D-alanine into membrane-associated D-alanyl-lipoteichoic acid; D-alanyl carrier protein is the acceptor of activated D-alanine which it donates to a membrane acceptor(D-alanyl transferase) for incorporation into membrane lipoteichoic acid; D-alanine--poly(phosphoribitol) ligase subunit 2 1978713 dltC 4442205 dltC Streptococcus pneumoniae D39 D-alanine--poly(phosphoribitol) ligase subunit 2 YP_817389.1 1978474 R 373153 CDS YP_817390.1 116515437 4441284 complement(1978727..1979971) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2175; equivalent gene in S.pneumoniae R6 = spr1981; identified by match to protein family HMM PF03062; protein DltB 1979971 dltB 4441284 dltB Streptococcus pneumoniae D39 protein DltB YP_817390.1 1978727 R 373153 CDS YP_817391.1 116516471 4442941 complement(1979968..1981518) 1 NC_008533.1 transfers D-alanine to the D-alanyl carrier protein during the incorporation of D-alanine into lipoteichoic acid; D-alanine--poly(phosphoribitol) ligase subunit 1 1981518 dltA 4442941 dltA Streptococcus pneumoniae D39 D-alanine--poly(phosphoribitol) ligase subunit 1 YP_817391.1 1979968 R 373153 CDS YP_817392.1 116516054 4442763 complement(1981539..1981670) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2177; hypothetical protein 1981670 4442763 SPD_2006 Streptococcus pneumoniae D39 hypothetical protein YP_817392.1 1981539 R 373153 CDS YP_817393.1 116517160 4441874 complement(1981984..1983162) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2180; equivalent gene in S.pneumoniae R6 = spr1983; identified by match to protein family HMM PF07690; transporter major facilitator family protein 1983162 4441874 SPD_2007 Streptococcus pneumoniae D39 transporter major facilitator family protein YP_817393.1 1981984 R 373153 CDS YP_817394.1 116516488 4443018 1986006..1986593 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2182; equivalent gene in S.pneumoniae R6 = spr1986; hypothetical protein 1986593 4443018 SPD_2009 Streptococcus pneumoniae D39 hypothetical protein YP_817394.1 1986006 D 373153 CDS YP_817395.1 116515697 4441438 complement(1986680..1986826) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2183; equivalent gene in S.pneumoniae R6 = spr1987; hypothetical protein 1986826 4441438 SPD_2010 Streptococcus pneumoniae D39 hypothetical protein YP_817395.1 1986680 R 373153 CDS YP_817396.1 116516308 4442597 complement(1987074..1987778) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2184; equivalent gene in S.pneumoniae R6 = spr1988; identified by match to protein family HMM PF00230; match to protein family HMM TIGR00861; glycerol uptake facilitator protein 1987778 glpF 4442597 glpF Streptococcus pneumoniae D39 glycerol uptake facilitator protein YP_817396.1 1987074 R 373153 CDS YP_817397.1 116516239 4441519 complement(1987848..1989674) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2185; equivalent gene in S.pneumoniae R6 = spr1990; identified by match to protein family HMM PF01266; alpha-glycerophosphate oxidase 1989674 glpO 4441519 glpO Streptococcus pneumoniae D39 alpha-glycerophosphate oxidase YP_817397.1 1987848 R 373153 CDS YP_817398.1 116516212 4441472 complement(1989716..1991224) 1 NC_008533.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase 1991224 glpK 4441472 glpK Streptococcus pneumoniae D39 glycerol kinase YP_817398.1 1989716 R 373153 CDS YP_817399.1 116516714 4442340 complement(1991383..1992810) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2187; equivalent gene in S.pneumoniae R6 = spr1992; identified by match to protein family HMM PF05043; hypothetical protein 1992810 4442340 SPD_2014 Streptococcus pneumoniae D39 hypothetical protein YP_817399.1 1991383 R 373153 CDS YP_817400.1 116515969 4441411 1992975..1993847 1 NC_008533.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; Hsp33-like chaperonin 1993847 hslO 4441411 hslO Streptococcus pneumoniae D39 Hsp33-like chaperonin YP_817400.1 1992975 D 373153 CDS YP_817401.1 116516462 4442932 1993858..1994814 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2189; equivalent gene in S.pneumoniae R6 = spr1994; identified by match to protein family HMM PF01180; match to protein family HMM PF01207; match to protein family HMM TIGR00737; TIM-barrel protein, nifR3 family protein 1994814 4442932 SPD_2016 Streptococcus pneumoniae D39 TIM-barrel protein, nifR3 family protein YP_817401.1 1993858 D 373153 CDS YP_817402.1 116515359 4441159 complement(1995044..1997149) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr1995 This gene is also called SpsA, pspC (pneumococcal surface protein C)and Hic; identified by match to protein family HMM PF01473; match to protein family HMM PF04650; match to protein family HMM PF05062; match to protein family HMM TIGR01168; choline binding protein A 1997149 cbpA 4441159 cbpA Streptococcus pneumoniae D39 choline binding protein A YP_817402.1 1995044 R 373153 CDS YP_817403.1 116516618 4442396 complement(1997228..1997755) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2191; equivalent gene in S.pneumoniae R6 = spr1996; identified by match to protein family HMM PF04140; hypothetical protein 1997755 4442396 SPD_2018 Streptococcus pneumoniae D39 hypothetical protein YP_817403.1 1997228 R 373153 CDS YP_817404.1 116515721 4442259 complement(1997838..1999169) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2192; equivalent gene in S.pneumoniae R6 = spr1997; identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518; sensor histidine kinase 1999169 4442259 SPD_2019 Streptococcus pneumoniae D39 sensor histidine kinase YP_817404.1 1997838 R 373153 CDS YP_817405.1 116516299 4442588 complement(1999166..1999819) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2193; equivalent gene in S.pneumoniae R6 = spr1998; identified by match to protein family HMM PF00072; match to protein family HMM PF00486; DNA-binding response regulator 1999819 4442588 SPD_2020 Streptococcus pneumoniae D39 DNA-binding response regulator YP_817405.1 1999166 R 373153 CDS YP_817406.1 116515451 4441175 complement(2000108..2000242) 1 NC_008533.1 hypothetical protein 2000242 4441175 SPD_2021 Streptococcus pneumoniae D39 hypothetical protein YP_817406.1 2000108 R 373153 CDS YP_817407.1 116516069 4442525 complement(2000461..2002893) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2194; equivalent gene in S.pneumoniae R6 = spr2000; identified by match to protein family HMM PF00004; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM PF07728; ATP-dependent Clp protease, ATP-binding subunit 2002893 4442525 SPD_2022 Streptococcus pneumoniae D39 ATP-dependent Clp protease, ATP-binding subunit YP_817407.1 2000461 R 373153 CDS YP_817408.1 116516436 4441662 complement(2002895..2003353) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2195; equivalent gene in S.pneumoniae R6 = spr2001; identified by match to protein family HMM PF05848; CtsR family transcriptional regulator 2003353 ctsR 4441662 ctsR Streptococcus pneumoniae D39 CtsR family transcriptional regulator YP_817408.1 2002895 R 373153 CDS YP_817409.1 116517002 4441986 complement(2003472..2004200) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2196; equivalent gene in S.pneumoniae R6 = spr2002; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 2004200 4441986 SPD_2024 Streptococcus pneumoniae D39 ABC transporter ATP-binding protein YP_817409.1 2003472 R 373153 CDS YP_817410.1 116516189 4441146 complement(2004200..2005207) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2197; equivalent gene in S.pneumoniae R6 = spr2003; ABC transporter substrate-binding protein 2005207 4441146 SPD_2025 Streptococcus pneumoniae D39 ABC transporter substrate-binding protein YP_817410.1 2004200 R 373153 CDS YP_817411.1 116515916 4441059 complement(2005245..2005961) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2198; equivalent gene in S.pneumoniae R6 = spr2004; identified by match to protein family HMM PF00528; ABC transporter permease 2005961 4441059 SPD_2026 Streptococcus pneumoniae D39 ABC transporter permease YP_817411.1 2005245 R 373153 CDS YP_817412.1 116516871 4442114 complement(2005966..2006256) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2199; equivalent gene in S.pneumoniae R6 = spr2005; hypothetical protein 2006256 4442114 SPD_2027 Streptococcus pneumoniae D39 hypothetical protein YP_817412.1 2005966 R 373153 CDS YP_817413.1 116516664 4442443 complement(2006512..2007858) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2201; equivalent gene in S.pneumoniae R6 = spr2006; identified by match to protein family HMM PF01473; match to protein family HMM PF05257; choline binding protein D 2007858 cbpD 4442443 cbpD Streptococcus pneumoniae D39 choline binding protein D YP_817413.1 2006512 R 373153 CDS YP_817414.1 116515580 4441198 complement(2007947..2008213) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2202; equivalent gene in S.pneumoniae R6 = spr2007; identified by match to protein family HMM PF06257; hypothetical protein 2008213 4441198 SPD_2029 Streptococcus pneumoniae D39 hypothetical protein YP_817414.1 2007947 R 373153 CDS YP_817415.1 116516432 4441658 complement(2008215..2009567) 1 NC_008533.1 unwinds double stranded DNA; replicative DNA helicase 2009567 dnaB 4441658 dnaB Streptococcus pneumoniae D39 replicative DNA helicase YP_817415.1 2008215 R 373153 CDS YP_817416.1 116515335 4441077 complement(2009611..2010063) 1 NC_008533.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 2010063 rplI 4441077 rplI Streptococcus pneumoniae D39 50S ribosomal protein L9 YP_817416.1 2009611 R 373153 CDS YP_817417.1 116516911 4442059 complement(2010060..2012033) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2205; equivalent gene in S.pneumoniae R6 = spr2010; identified by match to protein family HMM PF01368; match to protein family HMM PF02272; DHH subfamily 1 protein 2012033 4442059 SPD_2032 Streptococcus pneumoniae D39 DHH subfamily 1 protein YP_817417.1 2010060 R 373153 CDS YP_817418.1 116516918 4442067 complement(2012169..2012717) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2206; equivalent gene in S.pneumoniae R6 = spr2011; identified by match to protein family HMM PF02482; match to protein family HMM TIGR00741; ribosomal subunit interface protein 2012717 yfiA 4442067 yfiA Streptococcus pneumoniae D39 ribosomal subunit interface protein YP_817418.1 2012169 R 373153 CDS YP_817419.1 116515869 4441105 complement(2012797..2013459) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2207; equivalent gene in S.pneumoniae R6 = spr2012; competence protein ComF 2013459 4441105 SPD_2034 Streptococcus pneumoniae D39 competence protein ComF YP_817419.1 2012797 R 373153 CDS YP_817420.1 116516737 4442287 complement(2013456..2014754) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2208; equivalent gene in S.pneumoniae R6 = spr2013; identified by match to protein family HMM PF00271; match to protein family HMM PF04851; helicase 2014754 4442287 SPD_2035 Streptococcus pneumoniae D39 helicase YP_817420.1 2013456 R 373153 CDS YP_817421.1 116515439 4441286 2014810..2015445 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2209; equivalent gene in S.pneumoniae R6 = spr2014; identified by match to protein family HMM PF01205; match to protein family HMM TIGR00257; hypothetical protein 2015445 4441286 SPD_2036 Streptococcus pneumoniae D39 hypothetical protein YP_817421.1 2014810 D 373153 CDS YP_817422.1 116516389 4441595 2015730..2016650 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2210; equivalent gene in S.pneumoniae R6 = spr2015; identified by match to protein family HMM PF00291; match to protein family HMM TIGR01136; match to protein family HMM TIGR01139; cysteine synthase A 2016650 cysK 4441595 cysK Streptococcus pneumoniae D39 cysteine synthase A YP_817422.1 2015730 D 373153 CDS YP_817423.1 116515632 4442712 complement(2016847..2017116) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr2016; hypothetical protein 2017116 4442712 SPD_2038 Streptococcus pneumoniae D39 hypothetical protein YP_817423.1 2016847 R 373153 CDS YP_817424.1 116516076 4442533 complement(2018234..2019274) 1 NC_008533.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 2019274 tsf 4442533 tsf Streptococcus pneumoniae D39 elongation factor Ts YP_817424.1 2018234 R 373153 CDS YP_817425.1 116517128 4442366 complement(2019340..2020119) 1 NC_008533.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 2020119 rpsB 4442366 rpsB Streptococcus pneumoniae D39 30S ribosomal protein S2 YP_817425.1 2019340 R 373153 CDS YP_817426.1 116516590 4441219 complement(2020343..2021521) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2216; equivalent gene in S.pneumoniae R6 = spr2021; identified by match to protein family HMM PF05257; hypothetical protein 2021521 4441219 SPD_2043 Streptococcus pneumoniae D39 hypothetical protein YP_817426.1 2020343 R 373153 CDS YP_817427.1 116515493 4441303 complement(2021615..2022109) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2217; equivalent gene in S.pneumoniae R6 = spr2022; identified by match to protein family HMM PF04093; rod shpae-determining protein MreD 2022109 4441303 SPD_2044 Streptococcus pneumoniae D39 rod shpae-determining protein MreD YP_817427.1 2021615 R 373153 CDS YP_817428.1 116516374 4443036 complement(2022109..2022927) 1 NC_008533.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall; rod shape-determining protein MreC 2022927 mreC 4443036 mreC Streptococcus pneumoniae D39 rod shape-determining protein MreC YP_817428.1 2022109 R 373153 CDS YP_817429.1 116516262 4441772 complement(2022986..2023780) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2219; equivalent gene in S.pneumoniae R6 = spr2024; identified by match to protein family HMM PF02361; cobalt ABC transporter permease 2023780 4441772 SPD_2046 Streptococcus pneumoniae D39 cobalt ABC transporter permease YP_817429.1 2022986 R 373153 CDS YP_817430.1 116517082 4441932 complement(2023773..2024612) 1 NC_008533.1 with CbiNQ forms the ABC transporter for cobalt import; Streptococcus has two adjacent copies of this gene; cobalt transporter ATP-binding subunit 2024612 cbiO 4441932 cbiO Streptococcus pneumoniae D39 cobalt transporter ATP-binding subunit YP_817430.1 2023773 R 373153 CDS YP_817431.1 116515987 4442439 complement(2024597..2025424) 1 NC_008533.1 with CbiNQ forms the ABC transporter for cobalt import; Streptococcus has two adjacent copies of this gene; cobalt transporter ATP-binding subunit 2025424 cbiO 4442439 cbiO Streptococcus pneumoniae D39 cobalt transporter ATP-binding subunit YP_817431.1 2024597 R 373153 CDS YP_817432.1 116516876 4442119 complement(2025421..2025966) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2222; equivalent gene in S.pneumoniae R6 = spr2027; identified by match to protein family HMM PF01066; match to protein family HMM TIGR00560; CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase 2025966 pgsA 4442119 pgsA Streptococcus pneumoniae D39 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase YP_817432.1 2025421 R 373153 CDS YP_817433.1 116515748 4442403 complement(2025977..2026798) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2223; equivalent gene in S.pneumoniae R6 = spr2028; hypothetical protein 2026798 4442403 SPD_2050 Streptococcus pneumoniae D39 hypothetical protein YP_817433.1 2025977 R 373153 CDS YP_817434.1 116516624 4441412 complement(2026840..2028123) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2224; equivalent gene in S.pneumoniae R6 = spr2029; identified by match to protein family HMM PF00675; match to protein family HMM PF05193; peptidase, M16 family protein 2028123 4441412 SPD_2051 Streptococcus pneumoniae D39 peptidase, M16 family protein YP_817434.1 2026840 R 373153 CDS YP_817435.1 116515448 4441295 complement(2028120..2029370) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2225; equivalent gene in S.pneumoniae R6 = spr2030; identified by match to protein family HMM PF05193; hypothetical protein 2029370 4441295 SPD_2052 Streptococcus pneumoniae D39 hypothetical protein YP_817435.1 2028120 R 373153 CDS YP_817436.1 116515378 4441614 2029529..2029897 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2226; equivalent gene in S.pneumoniae R6 = spr2031; hypothetical protein 2029897 4441614 SPD_2053 Streptococcus pneumoniae D39 hypothetical protein YP_817436.1 2029529 D 373153 CDS YP_817437.1 116516540 4441043 2029900..2030997 1 NC_008533.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 2030997 recF 4441043 recF Streptococcus pneumoniae D39 recombination protein F YP_817437.1 2029900 D 373153 CDS YP_817438.1 116515965 4441407 complement(2031048..2032526) 1 NC_008533.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase 2032526 guaB 4441407 guaB Streptococcus pneumoniae D39 inosine 5'-monophosphate dehydrogenase YP_817438.1 2031048 R 373153 CDS YP_817439.1 116516810 4442206 complement(2032678..2033703) 1 NC_008533.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase II 2033703 trpS 4442206 trpS Streptococcus pneumoniae D39 tryptophanyl-tRNA synthetase II YP_817439.1 2032678 R 373153 CDS YP_817440.1 116515858 4441094 2033909..2035531 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2230; equivalent gene in S.pneumoniae R6 = spr2035; identified by match to protein family HMM PF00005; ABC transporter ATP-binding protein 2035531 4441094 SPD_2057 Streptococcus pneumoniae D39 ABC transporter ATP-binding protein YP_817440.1 2033909 D 373153 CDS YP_817441.1 116516813 4442170 2035593..2038145 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2231; equivalent gene in S.pneumoniae R6 = spr2036; ABC transporter permease 2038145 4442170 SPD_2058 Streptococcus pneumoniae D39 ABC transporter permease YP_817441.1 2035593 D 373153 CDS YP_817442.1 116516592 4441221 2039957..2040499 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2234; equivalent gene in S.pneumoniae R6 = spr2040; identified by match to protein family HMM PF00440; transcriptional regulator, TetR family protein 2040499 4441221 SPD_2060 Streptococcus pneumoniae D39 transcriptional regulator, TetR family protein YP_817442.1 2039957 D 373153 CDS YP_817443.1 116515497 4441307 complement(2040742..2041494) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2235; equivalent gene in S.pneumoniae R6 = spr2041; identified by match to protein family HMM PF00072; match to protein family HMM PF04397; response regulator 2041494 comE 4441307 comE Streptococcus pneumoniae D39 response regulator YP_817443.1 2040742 R 373153 CDS YP_817444.1 116515505 4442986 complement(2041491..2042816) 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2236; equivalent gene in S.pneumoniae R6 = spr2042; identified by match to protein family HMM PF02518; sensor histidine kinase ComD 2042816 comD 4442986 comD Streptococcus pneumoniae D39 sensor histidine kinase ComD YP_817444.1 2041491 R 373153 CDS YP_817445.1 116517067 4441955 complement(2042837..2042962) 1 NC_008533.1 equivalent gene in S.pneumoniae R6 = spr2043; identified by match to protein family HMM PF03047; competence-stimulating peptide type 1 2042962 comC1 4441955 comC1 Streptococcus pneumoniae D39 competence-stimulating peptide type 1 YP_817445.1 2042837 R 373153 CDS YP_817446.1 116515560 4442870 complement(2043244..2043723) 1 NC_008533.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase 2043723 4442870 SPD_2067 Streptococcus pneumoniae D39 rRNA large subunit methyltransferase YP_817446.1 2043244 R 373153 CDS YP_817447.1 116516698 4442324 2043906..2045087 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2239; equivalent gene in S.pneumoniae R6 = spr2045; identified by match to protein family HMM PF00089; serine protease 2045087 4442324 SPD_2068 Streptococcus pneumoniae D39 serine protease YP_817447.1 2043906 D 373153 CDS YP_817448.1 116515747 4442402 2045145..2045903 1 NC_008533.1 equivalent gene in S.pneumoniae TIGR4 = SP2240; equivalent gene in S.pneumoniae R6 = spr2046; identified by match to protein family HMM PF02195; match to protein family HMM TIGR00180; SpoJ protein 2045903 4442402 SPD_2069 Streptococcus pneumoniae D39 SpoJ protein YP_817448.1 2045145 D 373153 CDS