-- dump date 20140620_084513 -- class Genbank::CDS -- table cds_note -- id note YP_815417.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. YP_815419.1 binds the polymerase to DNA and acts as a sliding clamp YP_815421.1 equivalent gene in S.pneumoniae TIGR4 = SP0003; equivalent gene in S.pneumoniae R6 = spr0003; identified by match to protein family HMM PF06107 YP_815423.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 YP_815426.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation YP_815427.1 equivalent gene in S.pneumoniae TIGR4 = SP0006; equivalent gene in S.pneumoniae R6 = spr0006; identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM PF02559; match to protein family HMM PF03461; match to protein family HMM PF04851; match to protein family HMM TIGR00580 YP_815429.1 equivalent gene in S.pneumoniae TIGR4 = SP0007; equivalent gene in S.pneumoniae R6 = spr0007; identified by match to protein family HMM PF01479 YP_815431.1 equivalent gene in S.pneumoniae TIGR4 = SP0008; equivalent gene in S.pneumoniae R6 = spr0008; identified by match to protein family HMM PF04977 YP_815432.1 equivalent gene in S.pneumoniae TIGR4 = SP0009 YP_815433.1 equivalent gene in S.pneumoniae TIGR4 = SP0010; equivalent gene in S.pneumoniae R6 = spr0009 YP_815434.1 equivalent gene in S.pneumoniae TIGR4 = SP0011; equivalent gene in S.pneumoniae R6 = spr0010; identified by match to protein family HMM PF01171; match to protein family HMM TIGR02432; match to protein family HMM TIGR02433 YP_815435.1 equivalent gene in S.pneumoniae TIGR4 = SP0012; equivalent gene in S.pneumoniae R6 = spr0011; identified by match to protein family HMM PF00156; match to protein family HMM TIGR01203 YP_815436.1 equivalent gene in S.pneumoniae TIGR4 = SP0013; equivalent gene in S.pneumoniae R6 = spr0012; identified by match to protein family HMM PF00004; match to protein family HMM PF01434; match to protein family HMM PF06480; match to protein family HMM TIGR01241 YP_815437.1 equivalent gene in S.pneumoniae TIGR4 = SP0014; equivalent gene in S.pneumoniae R6 = spr0013 YP_815438.1 equivalent gene in S.pneumoniae TIGR4 = SP0018; equivalent gene in S.pneumoniae R6 = spr0020 YP_815439.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis YP_815440.1 equivalent gene in S.pneumoniae TIGR4 = SP0020; equivalent gene in S.pneumoniae R6 = spr0022; identified by match to protein family HMM PF00383 YP_815441.1 catalyzes the formation of dUMP from dUTP YP_815442.1 equivalent gene in S.pneumoniae TIGR4 = SP0022; equivalent gene in S.pneumoniae R6 = spr0024; identified by match to protein family HMM PF00300 YP_815444.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents YP_815447.1 equivalent gene in S.pneumoniae TIGR4 = SP0024; equivalent gene in S.pneumoniae R6 = spr0026; identified by match to protein family HMM PF00484 YP_815449.1 equivalent gene in S.pneumoniae TIGR4 = SP0026; equivalent gene in S.pneumoniae R6 = spr0027 YP_815451.1 equivalent gene in S.pneumoniae TIGR4 = SP0026 YP_815453.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP YP_815455.1 equivalent gene in S.pneumoniae TIGR4 = SP0029; equivalent gene in S.pneumoniae R6 = spr0030 YP_815459.1 equivalent gene in S.pneumoniae TIGR4 = SP0031; equivalent gene in S.pneumoniae R6 = spr0031 YP_815461.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair YP_815463.1 equivalent gene in S.pneumoniae TIGR4 = SP0033; equivalent gene in S.pneumoniae R6 = spr0033; identified by match to protein family HMM PF02629 YP_815466.1 equivalent gene in S.pneumoniae TIGR4 = SP0034; equivalent gene in S.pneumoniae R6 = spr0034; identified by match to protein family HMM PF03601 YP_815468.1 catalyzes the transamination of the aromatic amino acid forming a ketoacid; first step in aromatic amino acid degradation in lactococci YP_815471.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA YP_815473.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY YP_815476.1 equivalent gene in S.pneumoniae TIGR4 = SP0038; equivalent gene in S.pneumoniae R6 = spr0038 YP_815478.1 equivalent gene in S.pneumoniae TIGR4 = SP0041; equivalent gene in S.pneumoniae R6 = spr0040; identified by match to protein family HMM TIGR01847 YP_815482.1 equivalent gene in S.pneumoniae TIGR4 = SP0042; equivalent gene in S.pneumoniae R6 = spr0043; identified by match to protein family HMM PF00005; match to protein family HMM PF00664; match to protein family HMM PF03412; match to protein family HMM TIGR01193 YP_815485.1 equivalent gene in S.pneumoniae TIGR4 = SP0043; equivalent gene in S.pneumoniae R6 = spr0044; identified by match to protein family HMM TIGR01000 YP_815487.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase YP_815489.1 equivalent gene in S.pneumoniae TIGR4 = SP0045; equivalent gene in S.pneumoniae R6 = spr0046; identified by match to protein family HMM PF02769; match to protein family HMM TIGR01857 YP_815491.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway YP_815493.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis YP_815495.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate YP_815498.1 equivalent gene in S.pneumoniae TIGR4 = SP0049; equivalent gene in S.pneumoniae R6 = spr0050; identified by match to protein family HMM PF04892 YP_815500.1 involved in de novo purine biosynthesis YP_815502.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis YP_815504.1 equivalent gene in S.pneumoniae TIGR4 = SP0053; equivalent gene in S.pneumoniae R6 = spr0053; identified by match to protein family HMM PF00731; match to protein family HMM TIGR01162 YP_815506.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway YP_815508.1 equivalent gene in S.pneumoniae TIGR4 = SP0055; equivalent gene in S.pneumoniae R6 = spr0055 YP_815510.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide YP_815512.1 equivalent gene in S.pneumoniae TIGR4 = SP0057; equivalent gene in S.pneumoniae R6 = spr0057; identified by match to protein family HMM PF00728; match to protein family HMM PF00746; match to protein family HMM PF04650; match to protein family HMM PF07501; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168 YP_815514.1 equivalent gene in S.pneumoniae TIGR4 = SP0058; equivalent gene in S.pneumoniae R6 = spr0058; identified by match to protein family HMM PF00392; match to protein family HMM PF07702 YP_815516.1 equivalent gene in S.pneumoniae TIGR4 = SP0060; equivalent gene in S.pneumoniae R6 = spr0059; identified by match to protein family HMM PF01301; match to protein family HMM PF02449 YP_815518.1 equivalent gene in S.pneumoniae TIGR4 = SP0061; equivalent gene in S.pneumoniae R6 = spr0060; identified by match to protein family HMM PF03830 YP_815520.1 equivalent gene in S.pneumoniae TIGR4 = SP0062; equivalent gene in S.pneumoniae R6 = spr0061; identified by match to protein family HMM PF03609 YP_815521.1 equivalent gene in S.pneumoniae TIGR4 = SP0063; equivalent gene in S.pneumoniae R6 = spr0062; identified by match to protein family HMM PF03613 YP_815523.1 equivalent gene in S.pneumoniae TIGR4 = SP0064; equivalent gene in S.pneumoniae R6 = spr0063; identified by match to protein family HMM PF03610 YP_815524.1 equivalent gene in S.pneumoniae TIGR4 = SP0065; equivalent gene in S.pneumoniae R6 = spr0064; identified by match to protein family HMM PF01380 YP_815527.1 equivalent gene in S.pneumoniae TIGR4 = SP0066; equivalent gene in S.pneumoniae R6 = spr0065; identified by match to protein family HMM PF01263 YP_815529.1 equivalent gene in S.pneumoniae R6 = spr0066; identified by match to protein family HMM PF00903 YP_815531.1 equivalent gene in S.pneumoniae R6 = spr0067; identified by match to protein family HMM PF02583 YP_815532.1 equivalent gene in S.pneumoniae TIGR4 = SP0075; equivalent gene in S.pneumoniae R6 = spr0068; identified by match to protein family HMM PF01048 YP_815537.1 equivalent gene in S.pneumoniae TIGR4 = SP0078; equivalent gene in S.pneumoniae R6 = spr0070; identified by match to protein family HMM PF02386 YP_815540.1 equivalent gene in S.pneumoniae TIGR4 = SP0079; equivalent gene in S.pneumoniae R6 = spr0071; identified by match to protein family HMM PF02254 YP_815541.1 equivalent gene in S.pneumoniae R6 = spr0072; identified by match to protein family HMM PF00535 YP_815545.1 equivalent gene in S.pneumoniae R6 = spr0074 YP_815547.1 equivalent gene in S.pneumoniae R6 = spr0075; contains 6 repeats of 456-bp SSURE domain, exact sequence of repeats could not be determined. Placeholder sequence was inserted containing the 5 repeats used previously in spr0075 in the R6 genome sequence; identified by match to protein family HMM PF00746; match to protein family HMM PF04650; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168 YP_815548.1 equivalent gene in S.pneumoniae TIGR4 = SP0083; equivalent gene in S.pneumoniae R6 = spr0076; identified by match to protein family HMM PF00072; match to protein family HMM PF00486 YP_815550.1 equivalent gene in S.pneumoniae TIGR4 = SP0084; equivalent gene in S.pneumoniae R6 = spr0077; identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518 YP_815552.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination YP_815554.1 equivalent gene in S.pneumoniae TIGR4 = SP0086; equivalent gene in S.pneumoniae R6 = spr0014 In TIGR4 this gene is annotated as a truncation; however in R6 there are numerous near perfect copies as well as copies with a slightly longer version with a different end that is not present in either R6 or TIGR4 This indicates it may still function as a transposase. YP_815557.1 equivalent gene in S.pneumoniae TIGR4 = SP0087 YP_815560.1 equivalent gene in S.pneumoniae TIGR4 = SP0088; equivalent gene in S.pneumoniae R6 = spr0080 YP_815562.1 equivalent gene in S.pneumoniae TIGR4 = SP0089 YP_815564.1 equivalent gene in S.pneumoniae TIGR4 = SP0090; equivalent gene in S.pneumoniae R6 = spr0081; identified by match to protein family HMM PF00528 YP_815566.1 equivalent gene in S.pneumoniae TIGR4 = SP0091; equivalent gene in S.pneumoniae R6 = spr0082; identified by match to protein family HMM PF00528 YP_815568.1 equivalent gene in S.pneumoniae TIGR4 = SP0092; equivalent gene in S.pneumoniae R6 = spr0083; identified by match to protein family HMM PF01547 YP_815571.1 equivalent gene in S.pneumoniae TIGR4 = SP0095; equivalent gene in S.pneumoniae R6 = spr0084; identified by match to protein family HMM PF00581 YP_815572.1 equivalent gene in S.pneumoniae TIGR4 = SP0096; equivalent gene in S.pneumoniae R6 = spr0085 YP_815573.1 equivalent gene in S.pneumoniae TIGR4 = SP0097; equivalent gene in S.pneumoniae R6 = spr0086 YP_815575.1 equivalent gene in S.pneumoniae TIGR4 = SP0098; equivalent gene in S.pneumoniae R6 = spr0087 YP_815578.1 equivalent gene in S.pneumoniae TIGR4 = SP0099; equivalent gene in S.pneumoniae R6 = spr0088 YP_815579.1 equivalent gene in S.pneumoniae TIGR4 = SP0100; equivalent gene in S.pneumoniae R6 = spr0089; identified by match to protein family HMM PF03551 YP_815581.1 equivalent gene in S.pneumoniae TIGR4 = SP0101; equivalent gene in S.pneumoniae R6 = spr0090; identified by match to protein family HMM PF07690 YP_815584.1 equivalent gene in S.pneumoniae TIGR4 = SP0102; equivalent gene in S.pneumoniae R6 = spr0091; identified by match to protein family HMM PF00535 YP_815587.1 equivalent gene in S.pneumoniae TIGR4 = SP0103; equivalent gene in S.pneumoniae R6 = spr0092; identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF04321; match to protein family HMM PF07993 YP_815590.1 equivalent gene in S.pneumoniae TIGR4 = SP0104; equivalent gene in S.pneumoniae R6 = spr0093; identified by match to protein family HMM PF00702; match to protein family HMM TIGR01549 YP_815591.1 equivalent gene in S.pneumoniae TIGR4 = SP0105; equivalent gene in S.pneumoniae R6 = spr0094; identified by match to protein family HMM PF03313; match to protein family HMM TIGR00718 YP_815593.1 equivalent gene in S.pneumoniae TIGR4 = SP0106; equivalent gene in S.pneumoniae R6 = spr0095; identified by match to protein family HMM PF01842; match to protein family HMM PF03315; match to protein family HMM TIGR00719 YP_815595.1 equivalent gene in S.pneumoniae TIGR4 = SP0107; equivalent gene in S.pneumoniae R6 = spr0096; identified by match to protein family HMM PF01476 YP_815596.1 equivalent gene in S.pneumoniae TIGR4 = SP0114; equivalent gene in S.pneumoniae R6 = spr0097 YP_815600.1 equivalent gene in S.pneumoniae R6 = spr0098; identified by match to protein family HMM TIGR01653 YP_815603.1 equivalent gene in S.pneumoniae TIGR4 = SP0110; equivalent gene in S.pneumoniae R6 = spr0099; identified by match to protein family HMM TIGR01654 YP_815605.1 equivalent gene in S.pneumoniae TIGR4 = SP0111; equivalent gene in S.pneumoniae R6 = spr0100; identified by match to protein family HMM PF00005 YP_815607.1 equivalent gene in S.pneumoniae TIGR4 = SP0112; equivalent gene in S.pneumoniae R6 = spr0101; identified by match to protein family HMM PF00497 YP_815608.1 catalyzes the formation of 2-N(omega)-(L-arginino)succinate from L-citrulline and L-aspartate in arginine biosynthesis, AMP-forming YP_815610.1 catalyzes the formation of arginine from (N-L-arginino)succinate YP_815612.1 equivalent gene in S.pneumoniae TIGR4 = SP0108; equivalent gene in S.pneumoniae R6 = spr0104; identified by match to protein family HMM PF01381 YP_815614.1 equivalent gene in S.pneumoniae R6 = spr0107 YP_815617.1 equivalent gene in S.pneumoniae R6 = spr0108 YP_815619.1 equivalent gene in S.pneumoniae TIGR4 = SP0115; equivalent gene in S.pneumoniae R6 = spr0109 YP_815621.1 equivalent gene in S.pneumoniae R6 = spr0111 YP_815626.1 equivalent gene in S.pneumoniae R6 = spr0113 YP_815628.1 equivalent gene in S.pneumoniae R6 = spr0114 YP_815630.1 equivalent gene in S.pneumoniae R6 = spr0115 YP_815632.1 equivalent gene in S.pneumoniae R6 = spr0117 YP_815634.1 equivalent gene in S.pneumoniae R6 = spr0118 YP_815636.1 equivalent gene in S.pneumoniae R6 = spr0119 YP_815639.1 equivalent gene in S.pneumoniae TIGR4 = SP0116; equivalent gene in S.pneumoniae R6 = spr0120 YP_815641.1 equivalent gene in S.pneumoniae R6 = spr0121; identified by match to protein family HMM PF01473 YP_815643.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs YP_815645.1 equivalent gene in S.pneumoniae TIGR4 = SP0119; equivalent gene in S.pneumoniae R6 = spr0123; identified by match to protein family HMM PF00293 YP_815647.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs YP_815649.1 equivalent gene in S.pneumoniae TIGR4 = SP0121; equivalent gene in S.pneumoniae R6 = spr0125; identified by match to protein family HMM PF00753; match to protein family HMM PF07521; match to protein family HMM TIGR00649 YP_815651.1 equivalent gene in S.pneumoniae TIGR4 = SP0122; equivalent gene in S.pneumoniae R6 = spr0126; identified by match to protein family HMM PF07288 YP_815652.1 equivalent gene in S.pneumoniae TIGR4 = SP0124; equivalent gene in S.pneumoniae R6 = spr0127; identified by match to protein family HMM TIGR01847 YP_815653.1 equivalent gene in S.pneumoniae TIGR4 = SP0125; equivalent gene in S.pneumoniae R6 = spr0128 YP_815654.1 equivalent gene in S.pneumoniae TIGR4 = SP0127; equivalent gene in S.pneumoniae R6 = spr0129; identified by match to protein family HMM PF00814 YP_815655.1 equivalent gene in S.pneumoniae TIGR4 = SP0128; equivalent gene in S.pneumoniae R6 = spr0130; identified by match to protein family HMM PF00583; match to protein family HMM TIGR01575 YP_815656.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity YP_815657.1 equivalent gene in S.pneumoniae TIGR4 = SP0133; equivalent gene in S.pneumoniae R6 = spr0135; identified by match to protein family HMM PF00534 YP_815658.1 equivalent gene in S.pneumoniae TIGR4 = SP0136; equivalent gene in S.pneumoniae R6 = spr0136; identified by match to protein family HMM PF00535 YP_815659.1 equivalent gene in S.pneumoniae TIGR4 = SP0137; equivalent gene in S.pneumoniae R6 = spr0137; identified by match to protein family HMM PF00005 YP_815660.1 equivalent gene in S.pneumoniae TIGR4 = SP0138 YP_815661.1 equivalent gene in S.pneumoniae TIGR4 = SP0139; equivalent gene in S.pneumoniae R6 = spr0138; identified by match to protein family HMM PF02585 YP_815662.1 equivalent gene in S.pneumoniae R6 = spr0139; identified by match to protein family HMM PF00984; match to protein family HMM PF03721 YP_815663.1 equivalent gene in S.pneumoniae TIGR4 = SP0141; equivalent gene in S.pneumoniae R6 = spr0140; identified by match to protein family HMM TIGR01716 YP_815664.1 equivalent gene in S.pneumoniae TIGR4 = SP0142; equivalent gene in S.pneumoniae R6 = spr0141 YP_815665.1 equivalent gene in S.pneumoniae TIGR4 = SP0143; equivalent gene in S.pneumoniae R6 = spr0142; identified by match to protein family HMM PF02517 YP_815666.1 equivalent gene in S.pneumoniae TIGR4 = SP0144; equivalent gene in S.pneumoniae R6 = spr0143; identified by match to protein family HMM PF02517 YP_815667.1 equivalent gene in S.pneumoniae TIGR4 = SP0145; equivalent gene in S.pneumoniae R6 = spr0144; identified by match to protein family HMM PF07690 YP_815668.1 equivalent gene in S.pneumoniae TIGR4 = SP0146; equivalent gene in S.pneumoniae R6 = spr0145; identified by match to protein family HMM PF03591 YP_815669.1 equivalent gene in S.pneumoniae TIGR4 = SP0148; equivalent gene in S.pneumoniae R6 = spr0146; identified by match to protein family HMM PF00497 YP_815670.1 equivalent gene in S.pneumoniae TIGR4 = SP0149; equivalent gene in S.pneumoniae R6 = spr0147; identified by match to protein family HMM PF03180 YP_815671.1 equivalent gene in S.pneumoniae TIGR4 = SP0150; equivalent gene in S.pneumoniae R6 = spr0148; identified by match to protein family HMM PF01546; match to protein family HMM PF07687 YP_815672.1 equivalent gene in S.pneumoniae TIGR4 = SP0151; equivalent gene in S.pneumoniae R6 = spr0149; identified by match to protein family HMM PF00005 YP_815673.1 equivalent gene in S.pneumoniae TIGR4 = SP0152; equivalent gene in S.pneumoniae R6 = spr0150; identified by match to protein family HMM PF00528 YP_815674.1 equivalent gene in S.pneumoniae TIGR4 = SP0153; equivalent gene in S.pneumoniae R6 = spr0151; identified by match to protein family HMM TIGR02185 YP_815675.1 equivalent gene in S.pneumoniae TIGR4 = SP0154; equivalent gene in S.pneumoniae R6 = spr0152; identified by match to protein family HMM PF04854 YP_815676.1 equivalent gene in S.pneumoniae TIGR4 = SP0155; equivalent gene in S.pneumoniae R6 = spr0153; identified by match to protein family HMM PF00672; match to protein family HMM PF02518; match to protein family HMM PF06580 YP_815677.1 equivalent gene in S.pneumoniae TIGR4 = SP0156; equivalent gene in S.pneumoniae R6 = spr0154; identified by match to protein family HMM PF00072; match to protein family HMM PF00165 YP_815678.1 equivalent gene in S.pneumoniae TIGR4 = SP0157; equivalent gene in S.pneumoniae R6 = spr0155 YP_815679.1 has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF YP_815680.1 equivalent gene in S.pneumoniae TIGR4 = SP0159; equivalent gene in S.pneumoniae R6 = spr0157 YP_815681.1 equivalent gene in S.pneumoniae TIGR4 = SP0160; equivalent gene in S.pneumoniae R6 = spr0158 YP_815682.1 equivalent gene in S.pneumoniae TIGR4 = SP0161; equivalent gene in S.pneumoniae R6 = spr0159; identified by match to protein family HMM PF04397 YP_815683.1 equivalent gene in S.pneumoniae TIGR4 = SP0172 YP_815684.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex YP_815685.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not YP_815686.1 equivalent gene in S.pneumoniae TIGR4 = SP0176; equivalent gene in S.pneumoniae R6 = spr0162; identified by match to protein family HMM PF00925; match to protein family HMM PF00926; match to protein family HMM TIGR00505; match to protein family HMM TIGR00506 YP_815687.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine YP_815688.1 equivalent gene in S.pneumoniae TIGR4 = SP0178; equivalent gene in S.pneumoniae R6 = spr0164; identified by match to protein family HMM PF00383; match to protein family HMM PF01872; match to protein family HMM TIGR00227; match to protein family HMM TIGR00326 YP_815689.1 plays an essential role in ATP-dependent branch migration of the Holliday junction YP_815690.1 equivalent gene in S.pneumoniae TIGR4 = SP0180; equivalent gene in S.pneumoniae R6 = spr0166; identified by match to protein family HMM PF03352 YP_815691.1 equivalent gene in S.pneumoniae TIGR4 = SP0181; equivalent gene in S.pneumoniae R6 = spr0167; identified by match to protein family HMM PF02517 YP_815692.1 equivalent gene in S.pneumoniae TIGR4 = SP0182; equivalent gene in S.pneumoniae R6 = spr0168; identified by match to protein family HMM PF02016 YP_815693.1 equivalent gene in S.pneumoniae TIGR4 = SP0184; equivalent gene in S.pneumoniae R6 = spr0169; identified by match to protein family HMM PF06570 YP_815694.1 equivalent gene in S.pneumoniae TIGR4 = SP0185; equivalent gene in S.pneumoniae R6 = spr0170; identified by match to protein family HMM PF01544 YP_815695.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate YP_815696.1 equivalent gene in S.pneumoniae TIGR4 = SP0187; equivalent gene in S.pneumoniae R6 = spr0172; identified by match to protein family HMM PF00557 YP_815697.1 the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress YP_815698.1 equivalent gene in S.pneumoniae TIGR4 = SP0191; equivalent gene in S.pneumoniae R6 = spr0174 YP_815699.1 equivalent gene in S.pneumoniae TIGR4 = SP0192; equivalent gene in S.pneumoniae R6 = spr0175; identified by match to protein family HMM PF06135 YP_815700.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function YP_815701.1 equivalent gene in S.pneumoniae TIGR4 = SP0194; equivalent gene in S.pneumoniae R6 = spr0177; identified by match to protein family HMM PF06949 YP_815702.1 equivalent gene in S.pneumoniae TIGR4 = SP0197; equivalent gene in S.pneumoniae R6 = spr0178; identified by match to protein family HMM PF02875; match to protein family HMM TIGR01499 YP_815703.1 equivalent gene in S.pneumoniae R6 = spr0179 YP_815704.1 equivalent gene in S.pneumoniae TIGR4 = SP0199; equivalent gene in S.pneumoniae R6 = spr0180; identified by match to protein family HMM PF00614 YP_815705.1 equivalent gene in S.pneumoniae TIGR4 = SP0200; equivalent gene in S.pneumoniae R6 = spr0182 YP_815706.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates YP_815707.1 equivalent gene in S.pneumoniae TIGR4 = SP0203 YP_815708.1 equivalent gene in S.pneumoniae TIGR4 = SP0204; equivalent gene in S.pneumoniae R6 = spr0184; identified by match to protein family HMM PF00583 YP_815709.1 equivalent gene in S.pneumoniae TIGR4 = SP0205; equivalent gene in S.pneumoniae R6 = spr0185; identified by match to protein family HMM PF04055; match to protein family HMM TIGR02491 YP_815710.1 equivalent gene in S.pneumoniae TIGR4 = SP0207; equivalent gene in S.pneumoniae R6 = spr0186; identified by match to protein family HMM PF00485 YP_815711.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex YP_815712.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin YP_815713.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA YP_815714.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel YP_815715.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation YP_815716.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA YP_815717.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center YP_815718.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation YP_815719.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e YP_815720.1 one of the stabilizing components for the large ribosomal subunit YP_815721.1 primary binding protein; helps mediate assembly; involved in translation fidelity YP_815722.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase YP_815723.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel YP_815724.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 YP_815725.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif YP_815726.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit YP_815727.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance YP_815728.1 binds 5S rRNA along with protein L5 and L25 YP_815729.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance YP_815730.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7 YP_815731.1 late assembly protein YP_815732.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase YP_815733.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP YP_815734.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 YP_815735.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA YP_815736.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 YP_815737.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme YP_815738.1 is a component of the macrolide binding site in the peptidyl transferase center YP_815739.1 ACT domain-containing protein YP_815740.1 equivalent gene in S.pneumoniae TIGR4 = SP0240; equivalent gene in S.pneumoniae R6 = spr0219; identified by match to protein family HMM PF00300 YP_815741.1 equivalent gene in S.pneumoniae R6 = spr0220; identified by match to protein family HMM PF00528 YP_815742.1 equivalent gene in S.pneumoniae R6 = spr0221 YP_815743.1 equivalent gene in S.pneumoniae TIGR4 = SP0242; equivalent gene in S.pneumoniae R6 = spr0222; identified by match to protein family HMM PF00005 YP_815744.1 equivalent gene in S.pneumoniae TIGR4 = SP0243; equivalent gene in S.pneumoniae R6 = spr0223 YP_815745.1 equivalent gene in S.pneumoniae TIGR4 = SP0243; equivalent gene in S.pneumoniae R6 = spr0224 YP_815746.1 equivalent gene in S.pneumoniae R6 = spr0225; identified by match to protein family HMM PF00165 YP_815747.1 equivalent gene in S.pneumoniae TIGR4 = SP0245; equivalent gene in S.pneumoniae R6 = spr0226; identified by match to protein family HMM PF04055; match to protein family HMM TIGR02494 YP_815748.1 equivalent gene in S.pneumoniae TIGR4 = SP0246; equivalent gene in S.pneumoniae R6 = spr0227; identified by match to protein family HMM PF00455; match to protein family HMM PF08220 YP_815749.1 equivalent gene in S.pneumoniae TIGR4 = SP0247; equivalent gene in S.pneumoniae R6 = spr0228; identified by match to protein family HMM PF04198 YP_815750.1 equivalent gene in S.pneumoniae TIGR4 = SP0248; equivalent gene in S.pneumoniae R6 = spr0229; identified by match to protein family HMM PF02255 YP_815751.1 equivalent gene in S.pneumoniae TIGR4 = SP0249; equivalent gene in S.pneumoniae R6 = spr0230; identified by match to protein family HMM PF02302 YP_815752.1 equivalent gene in S.pneumoniae TIGR4 = SP0250; equivalent gene in S.pneumoniae R6 = spr0231; identified by match to protein family HMM PF02378; match to protein family HMM TIGR00410 YP_815753.1 equivalent gene in S.pneumoniae TIGR4 = SP0251; equivalent gene in S.pneumoniae R6 = spr0232; identified by match to protein family HMM PF01228; match to protein family HMM PF02901; match to protein family HMM TIGR01774 YP_815754.1 similar to transaldolase from Escherichia coli; many organisms have multiple copies YP_815755.1 forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone YP_815756.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase YP_815757.1 equivalent gene in S.pneumoniae TIGR4 = SP0255; equivalent gene in S.pneumoniae R6 = spr0236; identified by match to protein family HMM PF00583 YP_815758.1 equivalent gene in S.pneumoniae R6 = spr0237; identified by match to protein family HMM PF00583 YP_815759.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration YP_815760.1 equivalent gene in S.pneumoniae TIGR4 = SP0260; equivalent gene in S.pneumoniae R6 = spr0239; identified by match to protein family HMM PF06042 YP_815761.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate YP_815762.1 equivalent gene in S.pneumoniae TIGR4 = SP0262; equivalent gene in S.pneumoniae R6 = spr0241; identified by match to protein family HMM PF01148 YP_815763.1 equivalent gene in S.pneumoniae TIGR4 = SP0263; equivalent gene in S.pneumoniae R6 = spr0242; identified by match to protein family HMM PF02163; match to protein family HMM TIGR00054 YP_815764.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) YP_815765.1 equivalent gene in S.pneumoniae TIGR4 = SP0265; equivalent gene in S.pneumoniae R6 = spr0244; identified by match to protein family HMM PF00232 YP_815766.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source YP_815767.1 equivalent gene in S.pneumoniae TIGR4 = SP0267; equivalent gene in S.pneumoniae R6 = spr0246; identified by match to protein family HMM PF00296 YP_815768.1 equivalent gene in S.pneumoniae TIGR4 = SP0268; equivalent gene in S.pneumoniae R6 = spr0247; identified by match to protein family HMM PF00128; match to protein family HMM PF00746; match to protein family HMM PF02922; match to protein family HMM PF03714; match to protein family HMM PF04650; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168; match to protein family HMM TIGR02102 YP_815769.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance YP_815770.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit YP_815771.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_815772.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; required for leading strand synthesis; PolC exhibits 3' to 5' exonuclease activity YP_815773.1 equivalent gene in S.pneumoniae TIGR4 = SP0275; equivalent gene in S.pneumoniae R6 = spr0252; identified by match to protein family HMM PF04221; match to protein family HMM TIGR02384 YP_815774.1 equivalent gene in S.pneumoniae TIGR4 = SP0276; equivalent gene in S.pneumoniae R6 = spr0253; identified by match to protein family HMM PF05016; match to protein family HMM TIGR02385 YP_815775.1 equivalent gene in S.pneumoniae TIGR4 = SP0277 YP_815776.1 equivalent gene in S.pneumoniae TIGR4 = SP0278; equivalent gene in S.pneumoniae R6 = spr0254; identified by match to protein family HMM PF02073 YP_815777.1 equivalent gene in S.pneumoniae TIGR4 = SP0279; equivalent gene in S.pneumoniae R6 = spr0255; identified by match to protein family HMM PF04226 YP_815778.1 equivalent gene in S.pneumoniae TIGR4 = SP0280; equivalent gene in S.pneumoniae R6 = spr0256; identified by match to protein family HMM PF00849; match to protein family HMM PF01479; match to protein family HMM TIGR00093 YP_815779.1 equivalent gene in S.pneumoniae TIGR4 = SP0281; equivalent gene in S.pneumoniae R6 = spr0258; identified by match to protein family HMM PF03051 YP_815780.1 equivalent gene in S.pneumoniae TIGR4 = SP0282; equivalent gene in S.pneumoniae R6 = spr0259; identified by match to protein family HMM PF03613; match to protein family HMM TIGR00828 YP_815781.1 equivalent gene in S.pneumoniae TIGR4 = SP0283; equivalent gene in S.pneumoniae R6 = spr0260; identified by match to protein family HMM PF03609 YP_815782.1 equivalent gene in S.pneumoniae TIGR4 = SP0284; equivalent gene in S.pneumoniae R6 = spr0261; identified by match to protein family HMM PF03610; match to protein family HMM PF03830 YP_815783.1 similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs YP_815784.1 equivalent gene in S.pneumoniae TIGR4 = SP0286; equivalent gene in S.pneumoniae R6 = spr0263; identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484 YP_815785.1 equivalent gene in S.pneumoniae TIGR4 = SP0287; equivalent gene in S.pneumoniae R6 = spr0264; identified by match to protein family HMM PF00860 YP_815786.1 equivalent gene in S.pneumoniae TIGR4 = SP0288; equivalent gene in S.pneumoniae R6 = spr0265; identified by match to protein family HMM PF02517 YP_815787.1 equivalent gene in S.pneumoniae TIGR4 = SP0289; equivalent gene in S.pneumoniae R6 = spr0266; identified by match to protein family HMM PF00809; match to protein family HMM TIGR01496 YP_815788.1 equivalent gene in S.pneumoniae TIGR4 = SP0290; equivalent gene in S.pneumoniae R6 = spr0267; identified by match to protein family HMM PF02875; match to protein family HMM TIGR01499 YP_815789.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer YP_815790.1 equivalent gene in S.pneumoniae TIGR4 = SP0292; equivalent gene in S.pneumoniae R6 = spr0269; identified by match to protein family HMM PF01288; match to protein family HMM PF02152; match to protein family HMM TIGR00525; match to protein family HMM TIGR00526; match to protein family HMM TIGR01498 YP_815791.1 equivalent gene in S.pneumoniae TIGR4 = SP0293; equivalent gene in S.pneumoniae R6 = spr0270 YP_815792.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit YP_815793.1 forms a direct contact with the tRNA during translation YP_815794.1 equivalent gene in S.pneumoniae TIGR4 = SP0302; equivalent gene in S.pneumoniae R6 = spr0275; identified by match to protein family HMM PF03992 YP_815795.1 converts 6-phospho-beta-D-glucosyl-(1,4)-D-glucose to glucose and glucose 6-phosphate; required for cellobiose uptake and metabolism YP_815796.1 equivalent gene in S.pneumoniae TIGR4 = SP0304; equivalent gene in S.pneumoniae R6 = spr0277; identified by match to protein family HMM PF03083 YP_815797.1 required for cellobiose uptake and metabolism YP_815798.1 equivalent gene in S.pneumoniae TIGR4 = SP0306; equivalent gene in S.pneumoniae R6 = spr0279; identified by match to protein family HMM PF00874; match to protein family HMM PF05043 YP_815799.1 required for cellobiose uptake and metabolism YP_815800.1 equivalent gene in S.pneumoniae TIGR4 = SP0309; equivalent gene in S.pneumoniae R6 = spr0281 YP_815801.1 required for cellobiose uptake and metabolism YP_815802.1 equivalent gene in S.pneumoniae TIGR4 = SP0311; equivalent gene in S.pneumoniae R6 = spr0283 YP_815803.1 equivalent gene in S.pneumoniae TIGR4 = SP0312; equivalent gene in S.pneumoniae R6 = spr0284; identified by match to protein family HMM PF01055 YP_815804.1 equivalent gene in S.pneumoniae TIGR4 = SP0313; equivalent gene in S.pneumoniae R6 = spr0285; identified by match to protein family HMM PF00255 YP_815805.1 equivalent gene in S.pneumoniae TIGR4 = SP0314; equivalent gene in S.pneumoniae R6 = spr0286; identified by match to protein family HMM PF00746; match to protein family HMM PF02018; match to protein family HMM PF02278; match to protein family HMM PF02884; match to protein family HMM PF08124; match to protein family HMM TIGR01167 YP_815806.1 catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate YP_815807.1 equivalent gene in S.pneumoniae TIGR4 = SP0318; equivalent gene in S.pneumoniae R6 = spr0288; identified by match to protein family HMM PF00294 YP_815808.1 equivalent gene in S.pneumoniae TIGR4 = SP0319; equivalent gene in S.pneumoniae R6 = spr0289; identified by match to protein family HMM PF06562 YP_815809.1 Involved in the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate YP_815810.1 equivalent gene in S.pneumoniae TIGR4 = SP0321; equivalent gene in S.pneumoniae R6 = spr0291; identified by match to protein family HMM PF03610 YP_815811.1 equivalent gene in S.pneumoniae TIGR4 = SP0322; equivalent gene in S.pneumoniae R6 = spr0292; identified by match to protein family HMM PF07470 YP_815812.1 equivalent gene in S.pneumoniae TIGR4 = SP0323; equivalent gene in S.pneumoniae R6 = spr0293; identified by match to protein family HMM PF03830 YP_815813.1 equivalent gene in S.pneumoniae TIGR4 = SP0324; equivalent gene in S.pneumoniae R6 = spr0294; identified by match to protein family HMM PF03609 YP_815814.1 equivalent gene in S.pneumoniae TIGR4 = SP0325; equivalent gene in S.pneumoniae R6 = spr0295; identified by match to protein family HMM PF03613 YP_815815.2 equivalent gene in S.pneumoniae TIGR4 = SP0326; equivalent gene in S.pneumoniae R6 = spr0296 YP_815817.1 equivalent gene in S.pneumoniae TIGR4 = SP0327; equivalent gene in S.pneumoniae R6 = spr0297; identified by match to protein family HMM PF07940 YP_815818.1 equivalent gene in S.pneumoniae TIGR4 = SP0330; equivalent gene in S.pneumoniae R6 = spr0298; identified by match to protein family HMM PF00356; match to protein family HMM PF00532 YP_815819.1 equivalent gene in S.pneumoniae R6 = spr0300 YP_815820.1 equivalent gene in S.pneumoniae TIGR4 = SP0333; equivalent gene in S.pneumoniae R6 = spr0301; identified by match to protein family HMM PF01381 YP_815821.1 equivalent gene in S.pneumoniae TIGR4 = SP0334; equivalent gene in S.pneumoniae R6 = spr0302; identified by match to protein family HMM PF01795; match to protein family HMM TIGR00006 YP_815822.1 equivalent gene in S.pneumoniae TIGR4 = SP0335; equivalent gene in S.pneumoniae R6 = spr0303; identified by match to protein family HMM TIGR02209 YP_815823.1 equivalent gene in S.pneumoniae TIGR4 = SP0336; equivalent gene in S.pneumoniae R6 = spr0304; identified by match to protein family HMM PF00905; match to protein family HMM PF03717; match to protein family HMM PF03793 YP_815824.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan YP_815825.1 equivalent gene in S.pneumoniae TIGR4 = SP0338; equivalent gene in S.pneumoniae R6 = spr0307; identified by match to protein family HMM PF00004; match to protein family HMM PF07724; match to protein family HMM PF07728 YP_815826.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2 YP_815827.1 equivalent gene in S.pneumoniae TIGR4 = SP0341; equivalent gene in S.pneumoniae R6 = spr0309 YP_815828.1 equivalent gene in S.pneumoniae TIGR4 = SP0342; equivalent gene in S.pneumoniae R6 = spr0310; identified by match to protein family HMM PF00128 YP_815829.1 equivalent gene in S.pneumoniae R6 = spr0311 YP_815830.1 equivalent gene in S.pneumoniae TIGR4 = SP0346; equivalent gene in S.pneumoniae R6 = spr0314; identified by match to protein family HMM PF02916; match to protein family HMM PF03816; match to protein family HMM TIGR00350 YP_815831.1 equivalent gene in S.pneumoniae TIGR4 = SP0347; identified by match to protein family HMM PF02811 YP_815832.1 identified by match to protein family HMM PF02706; match to protein family HMM TIGR01006 YP_815833.1 identified by match to protein family HMM TIGR01007 YP_815834.1 Cps2E catalyzes the reversible addition of Glc-1-phosphate from UDP-Glc to a polyprenyl phosphate acceptor; identified by match to protein family HMM PF02397 YP_815835.1 identified by match to protein family HMM PF00534 YP_815836.1 identified by match to protein family HMM PF00535 YP_815837.1 identified by match to protein family HMM PF00534 YP_815838.1 Part of the type 2 capsule locus. equivalent gene in S.pneumoniae R6 = spr0315 YP_815839.1 equivalent gene in S.pneumoniae R6 = spr0316; identified by match to protein family HMM PF00534 YP_815840.1 equivalent gene in S.pneumoniae R6 = spr0317; identified by match to protein family HMM PF01943 YP_815841.1 equivalent gene in S.pneumoniae R6 = spr0318; identified by match to protein family HMM PF00984; match to protein family HMM PF01210; match to protein family HMM PF03720; match to protein family HMM PF03721 YP_815842.1 equivalent gene in S.pneumoniae R6 = spr0319; identified by match to protein family HMM PF03275 YP_815843.1 equivalent gene in S.pneumoniae R6 = spr0320; identified by match to protein family HMM PF00483; match to protein family HMM TIGR01207 YP_815844.1 equivalent gene in S.pneumoniae R6 = spr0321; identified by match to protein family HMM PF00908 YP_815845.1 equivalent gene in S.pneumoniae R6 = spr0322; identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF04321; match to protein family HMM PF07993; match to protein family HMM TIGR01181 YP_815846.1 equivalent gene in S.pneumoniae R6 = spr0323; identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF04321; match to protein family HMM PF07993; match to protein family HMM TIGR01214 YP_815847.1 equivalent gene in S.pneumoniae TIGR4 = SP0808; equivalent gene in S.pneumoniae R6 = spr0326 YP_815848.1 equivalent gene in S.pneumoniae TIGR4 = SP0366; equivalent gene in S.pneumoniae R6 = spr0327; identified by match to protein family HMM PF00496 YP_815849.1 equivalent gene in S.pneumoniae TIGR4 = SP0368; equivalent gene in S.pneumoniae R6 = spr0328; identified by match to protein family HMM PF00754; match to protein family HMM PF04650; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168 YP_815850.1 equivalent gene in S.pneumoniae TIGR4 = SP0369; equivalent gene in S.pneumoniae R6 = spr0329; identified by match to protein family HMM PF00905; match to protein family HMM PF00912; match to protein family HMM TIGR02074 YP_815851.1 functions in homologous recombination, DNA repair, and chromosome segregation; binds preferentially to three- and four-stranded DNA intermediates; introduces specific nick sites in four-stranded DNA substrates; functions similarly to Escherichia coli RuvC YP_815852.1 equivalent gene in S.pneumoniae TIGR4 = SP0371; equivalent gene in S.pneumoniae R6 = spr0331; identified by match to protein family HMM PF06908 YP_815853.1 equivalent gene in S.pneumoniae TIGR4 = SP0372; equivalent gene in S.pneumoniae R6 = spr0332; identified by match to protein family HMM PF05103 YP_815854.1 equivalent gene in S.pneumoniae TIGR4 = SP0373; equivalent gene in S.pneumoniae R6 = spr0333; identified by match to protein family HMM PF01170 YP_815855.1 equivalent gene in S.pneumoniae TIGR4 = SP0374; equivalent gene in S.pneumoniae R6 = spr0334 YP_815856.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate YP_815857.1 equivalent gene in S.pneumoniae TIGR4 = SP0376; equivalent gene in S.pneumoniae R6 = spr0336; identified by match to protein family HMM PF00072; match to protein family HMM PF00486 YP_815858.1 equivalent gene in S.pneumoniae R6 = spr0337; identified by similarity to GB:AAK745441; match to protein family HMM PF01473 YP_815859.1 equivalent gene in S.pneumoniae TIGR4 = SP0381; equivalent gene in S.pneumoniae R6 = spr0338; identified by match to protein family HMM PF00288; match to protein family HMM TIGR00549 YP_815860.1 equivalent gene in S.pneumoniae TIGR4 = SP0382; equivalent gene in S.pneumoniae R6 = spr0339; identified by match to protein family HMM PF00288; match to protein family HMM TIGR01240 YP_815861.1 equivalent gene in S.pneumoniae TIGR4 = SP0383; equivalent gene in S.pneumoniae R6 = spr0340; identified by match to protein family HMM PF00288; match to protein family HMM TIGR01220 YP_815862.1 catalyzes the isomerization of isopentenyl pyrophosphate to dimethylallyl diphosphate YP_815863.1 equivalent gene in S.pneumoniae TIGR4 = SP0385; equivalent gene in S.pneumoniae R6 = spr0342 YP_815864.1 equivalent gene in S.pneumoniae TIGR4 = SP0386; equivalent gene in S.pneumoniae R6 = spr0343; identified by match to protein family HMM PF02518; match to protein family HMM PF07730 YP_815865.1 equivalent gene in S.pneumoniae TIGR4 = SP0387; equivalent gene in S.pneumoniae R6 = spr0344; identified by match to protein family HMM PF00072; match to protein family HMM PF00196 YP_815866.1 equivalent gene in S.pneumoniae R6 = spr0345 YP_815867.1 equivalent gene in S.pneumoniae TIGR4 = SP0389; equivalent gene in S.pneumoniae R6 = spr0348 YP_815868.1 equivalent gene in S.pneumoniae R6 = spr0351; identified by match to protein family HMM PF01473 YP_815869.1 equivalent gene in S.pneumoniae TIGR4 = SP1596; equivalent gene in S.pneumoniae R6 = spr0355 YP_815870.1 equivalent gene in S.pneumoniae TIGR4 = SP0394; equivalent gene in S.pneumoniae R6 = spr0356; identified by match to protein family HMM PF02302; match to protein family HMM PF02378; match to protein family HMM TIGR00851 YP_815871.1 equivalent gene in S.pneumoniae TIGR4 = SP0395; equivalent gene in S.pneumoniae R6 = spr0357 YP_815872.1 equivalent gene in S.pneumoniae TIGR4 = SP0396; equivalent gene in S.pneumoniae R6 = spr0358; identified by match to protein family HMM PF00359 YP_815873.1 equivalent gene in S.pneumoniae TIGR4 = SP0397; equivalent gene in S.pneumoniae R6 = spr0359; identified by match to protein family HMM PF01232; match to protein family HMM PF08125 YP_815874.1 equivalent gene in S.pneumoniae TIGR4 = SP0399; equivalent gene in S.pneumoniae R6 = spr0361 YP_815875.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer YP_815876.1 equivalent gene in S.pneumoniae TIGR4 = SP0401; equivalent gene in S.pneumoniae R6 = spr0363; identified by match to protein family HMM TIGR01448 YP_815877.1 equivalent gene in S.pneumoniae TIGR4 = SP0402; equivalent gene in S.pneumoniae R6 = spr0364; identified by match to protein family HMM PF00717; match to protein family HMM TIGR02227 YP_815878.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids YP_815879.1 equivalent gene in S.pneumoniae TIGR4 = SP0404; equivalent gene in S.pneumoniae R6 = spr0366 YP_815880.1 equivalent gene in S.pneumoniae TIGR4 = SP0405; equivalent gene in S.pneumoniae R6 = spr0367; identified by match to protein family HMM PF02674 YP_815881.1 equivalent gene in S.pneumoniae TIGR4 = SP0406; equivalent gene in S.pneumoniae R6 = spr0368; identified by match to protein family HMM PF00488; match to protein family HMM PF01713; match to protein family HMM TIGR01069 YP_815882.1 equivalent gene in S.pneumoniae TIGR4 = SP0408; equivalent gene in S.pneumoniae R6 = spr0369; identified by match to protein family HMM PF01235; match to protein family HMM TIGR00835 YP_815883.1 equivalent gene in S.pneumoniae TIGR4 = SP0409; equivalent gene in S.pneumoniae R6 = spr0370; identified by match to protein family HMM PF02627; match to protein family HMM TIGR00778 YP_815884.1 equivalent gene in S.pneumoniae TIGR4 = SP0410; equivalent gene in S.pneumoniae R6 = spr0371; identified by match to protein family HMM PF03595 YP_815885.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_815886.1 equivalent gene in S.pneumoniae TIGR4 = SP0412; equivalent gene in S.pneumoniae R6 = spr0373; identified by match to protein family HMM PF06115 YP_815887.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; lysine and threonine sensitive YP_815888.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_815889.1 equivalent gene in S.pneumoniae TIGR4 = SP0416; equivalent gene in S.pneumoniae R6 = spr0376; identified by match to protein family HMM PF01047; match to protein family HMM PF03965 YP_815890.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs YP_815891.1 carries the fatty acid chain in fatty acid biosynthesis YP_815892.1 equivalent gene in S.pneumoniae TIGR4 = SP0419; equivalent gene in S.pneumoniae R6 = spr0379; identified by match to protein family HMM PF03060 YP_815893.1 equivalent gene in S.pneumoniae TIGR4 = SP0420; equivalent gene in S.pneumoniae R6 = spr0380; identified by match to protein family HMM PF00698; match to protein family HMM TIGR00128 YP_815894.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_815895.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP YP_815896.1 composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism YP_815897.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP YP_815898.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism YP_815899.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits YP_815900.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; these proteins present a shorter N-terminus YP_815901.1 equivalent gene in S.pneumoniae TIGR4 = SP0429; equivalent gene in S.pneumoniae R6 = spr0388 YP_815902.1 equivalent gene in S.pneumoniae TIGR4 = SP0430; equivalent gene in S.pneumoniae R6 = spr0389 YP_815903.1 Regulates rRNA biosynthesis by transcriptional antitermination YP_815904.1 equivalent gene in S.pneumoniae TIGR4 = SP0434; equivalent gene in S.pneumoniae R6 = spr0391; identified by match to protein family HMM PF03780 YP_815905.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA YP_815906.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_815907.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA YP_815908.1 allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases; reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA; some Mycoplasma proteins contain an N-terminal fusion to an unknown domain YP_815909.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein YP_815910.1 equivalent gene in S.pneumoniae R6 = spr0397; identified by match to protein family HMM PF01501 YP_815911.1 required for 70S ribosome assembly YP_815912.1 equivalent gene in S.pneumoniae TIGR4 = SP0442; equivalent gene in S.pneumoniae R6 = spr0399; identified by match to protein family HMM PF03780 YP_815913.1 equivalent gene in S.pneumoniae TIGR4 = SP0443; equivalent gene in S.pneumoniae R6 = spr0400; identified by match to protein family HMM PF02734 YP_815914.1 catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit YP_815915.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit YP_815916.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis YP_815917.1 equivalent gene in S.pneumoniae TIGR4 = SP0448; equivalent gene in S.pneumoniae R6 = spr0404 YP_815918.1 equivalent gene in S.pneumoniae TIGR4 = SP0449; equivalent gene in S.pneumoniae R6 = spr0405; identified by similarity to GB:AAK992091 YP_815919.1 catalyzes the formation of 2-oxobutanoate from L-threonine; biosynthetic YP_815920.1 equivalent gene in S.pneumoniae TIGR4 = SP0451; equivalent gene in S.pneumoniae R6 = spr0407 YP_815921.1 equivalent gene in S.pneumoniae TIGR4 = SP0452; equivalent gene in S.pneumoniae R6 = spr0408; identified by match to protein family HMM PF00005 YP_815922.1 equivalent gene in S.pneumoniae TIGR4 = SP0453; equivalent gene in S.pneumoniae R6 = spr0409; identified by match to protein family HMM PF00497; match to protein family HMM PF00528; match to protein family HMM TIGR01726 YP_815923.1 equivalent gene in S.pneumoniae TIGR4 = SP0454; equivalent gene in S.pneumoniae R6 = spr0410 YP_815924.1 equivalent gene in S.pneumoniae R6 = spr0411 YP_815925.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell YP_815926.1 equivalent gene in S.pneumoniae R6 = spr0346 YP_815927.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function YP_815928.1 equivalent gene in S.pneumoniae TIGR4 = SP0459; equivalent gene in S.pneumoniae R6 = spr0415; identified by match to protein family HMM PF01228; match to protein family HMM PF02901; match to protein family HMM TIGR01255 YP_815929.1 equivalent gene in S.pneumoniae R6 = spr0416 YP_815930.1 equivalent gene in S.pneumoniae TIGR4 = SP0471; equivalent gene in S.pneumoniae R6 = spr0417 YP_815931.1 equivalent gene in S.pneumoniae TIGR4 = SP0473; equivalent gene in S.pneumoniae R6 = spr0420; identified by match to protein family HMM PF00480 YP_815932.1 equivalent gene in S.pneumoniae TIGR4 = SP0474; equivalent gene in S.pneumoniae R6 = spr0421; identified by match to protein family HMM PF02378; match to protein family HMM TIGR00410 YP_815933.1 equivalent gene in S.pneumoniae TIGR4 = SP0475; equivalent gene in S.pneumoniae R6 = spr0422 YP_815934.1 equivalent gene in S.pneumoniae TIGR4 = SP0476; equivalent gene in S.pneumoniae R6 = spr0423; identified by match to protein family HMM PF02255 YP_815935.1 catalyzes the formation of 6-phospho-galactose from a 6-phospho-beta-galactoside YP_815936.1 equivalent gene in S.pneumoniae TIGR4 = SP0478; equivalent gene in S.pneumoniae R6 = spr0425; identified by match to protein family HMM PF02302; match to protein family HMM PF02378 YP_815937.1 equivalent gene in S.pneumoniae TIGR4 = SP0479; equivalent gene in S.pneumoniae R6 = spr0426; identified by match to protein family HMM PF02386 YP_815938.1 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain YP_815939.1 equivalent gene in S.pneumoniae TIGR4 = SP0481; equivalent gene in S.pneumoniae R6 = spr0428; identified by match to protein family HMM PF01887 YP_815940.1 equivalent gene in S.pneumoniae TIGR4 = SP0482; equivalent gene in S.pneumoniae R6 = spr0429; identified by match to protein family HMM PF07155 YP_815942.1 equivalent gene in S.pneumoniae TIGR4 = SP0483; equivalent gene in S.pneumoniae R6 = spr0430; identified by match to protein family HMM PF00005 YP_815943.1 equivalent gene in S.pneumoniae TIGR4 = SP0484; equivalent gene in S.pneumoniae R6 = spr0431; identified by match to protein family HMM PF02361 YP_815944.1 equivalent gene in S.pneumoniae TIGR4 = SP0486; equivalent gene in S.pneumoniae R6 = spr0432; identified by match to protein family HMM PF00588 YP_815945.1 equivalent gene in S.pneumoniae TIGR4 = SP0488; equivalent gene in S.pneumoniae R6 = spr0433 YP_815946.1 equivalent gene in S.pneumoniae TIGR4 = SP0489; equivalent gene in S.pneumoniae R6 = spr0434; identified by match to protein family HMM PF01569 YP_815947.1 equivalent gene in S.pneumoniae TIGR4 = SP0490; equivalent gene in S.pneumoniae R6 = spr0435 YP_815948.1 equivalent gene in S.pneumoniae TIGR4 = SP0492; equivalent gene in S.pneumoniae R6 = spr0436 YP_815949.1 participates in both the initiation and recycling phases of transcription; in the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling YP_815950.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer YP_815951.1 equivalent gene in S.pneumoniae TIGR4 = SP0496; equivalent gene in S.pneumoniae R6 = spr0439; identified by match to protein family HMM PF02690; match to protein family HMM TIGR00704 YP_815952.1 equivalent gene in S.pneumoniae TIGR4 = SP0498; equivalent gene in S.pneumoniae R6 = spr0440; identified by match to protein family HMM PF00746; match to protein family HMM PF00754; match to protein family HMM PF03644; match to protein family HMM PF07501; match to protein family HMM PF07523; match to protein family HMM PF07554; match to protein family HMM TIGR01167 YP_815953.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway YP_815954.1 equivalent gene in S.pneumoniae TIGR4 = SP0500; equivalent gene in S.pneumoniae R6 = spr0442 YP_815955.1 equivalent gene in S.pneumoniae TIGR4 = SP0501; equivalent gene in S.pneumoniae R6 = spr0443; identified by match to protein family HMM PF00376 YP_815956.1 equivalent gene in S.pneumoniae TIGR4 = SP0502; equivalent gene in S.pneumoniae R6 = spr0444; identified by match to protein family HMM PF00120; match to protein family HMM PF03951; match to protein family HMM TIGR00653 YP_815958.1 equivalent gene in S.pneumoniae R6 = spr0445; identified by match to protein family HMM PF01420 YP_815959.1 equivalent gene in S.pneumoniae TIGR4 = SP0507; equivalent gene in S.pneumoniae R6 = spr0446; identified by match to protein family HMM PF01420 YP_815960.1 equivalent gene in S.pneumoniae TIGR4 = SP0506; equivalent gene in S.pneumoniae R6 = spr0447; identified by match to protein family HMM PF00589 YP_815961.1 equivalent gene in S.pneumoniae R6 = spr0448; identified by match to protein family HMM PF01420 YP_815962.1 equivalent gene in S.pneumoniae TIGR4 = SP0509; equivalent gene in S.pneumoniae R6 = spr0449; identified by match to protein family HMM PF02384; match to protein family HMM PF05175 YP_815963.1 equivalent gene in S.pneumoniae TIGR4 = SP0510; equivalent gene in S.pneumoniae R6 = spr0450; identified by match to protein family HMM PF00270; match to protein family HMM PF04313; match to protein family HMM PF04851 YP_815964.1 equivalent gene in S.pneumoniae TIGR4 = SP0512; equivalent gene in S.pneumoniae R6 = spr0451 YP_815965.1 equivalent gene in S.pneumoniae TIGR4 = SP0514; equivalent gene in S.pneumoniae R6 = spr0452 YP_815966.1 Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons YP_815967.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor YP_815968.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria YP_815969.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion YP_815970.1 equivalent gene in S.pneumoniae TIGR4 = SP0520; equivalent gene in S.pneumoniae R6 = spr0457 YP_815971.1 equivalent gene in S.pneumoniae TIGR4 = SP0521; equivalent gene in S.pneumoniae R6 = spr0458; identified by match to protein family HMM PF01230 YP_815972.1 equivalent gene in S.pneumoniae TIGR4 = SP0522; equivalent gene in S.pneumoniae R6 = spr0459; identified by match to protein family HMM PF00005 YP_815973.1 equivalent gene in S.pneumoniae TIGR4 = SP0523; equivalent gene in S.pneumoniae R6 = spr0460; identified by match to protein family HMM PF05975 YP_815974.1 equivalent gene in S.pneumoniae TIGR4 = SP0524; equivalent gene in S.pneumoniae R6 = spr0461 YP_815975.1 equivalent gene in S.pneumoniae TIGR4 = SP0525; equivalent gene in S.pneumoniae R6 = spr0462; identified by match to protein family HMM PF04397 YP_815976.1 equivalent gene in S.pneumoniae TIGR4 = SP0526; equivalent gene in S.pneumoniae R6 = spr0463; identified by match to protein family HMM PF00072; match to protein family HMM PF04397 YP_815977.1 equivalent gene in S.pneumoniae R6 = spr0464; identified by match to protein family HMM PF02518 YP_815978.1 equivalent gene in S.pneumoniae TIGR4 = SP0528; equivalent gene in S.pneumoniae R6 = spr0465; identified by match to protein family HMM PF08128; match to protein family HMM TIGR01847 YP_815979.1 equivalent gene in S.pneumoniae TIGR4 = SP0545; equivalent gene in S.pneumoniae R6 = spr0472; identified by match to protein family HMM PF02517 YP_815980.1 equivalent gene in S.pneumoniae TIGR4 = SP0546; equivalent gene in S.pneumoniae R6 = spr0473 YP_815981.1 equivalent gene in S.pneumoniae TIGR4 = SP0547; equivalent gene in S.pneumoniae R6 = spr0474; identified by match to protein family HMM PF02517 YP_815982.1 equivalent gene in S.pneumoniae TIGR4 = SP0549; equivalent gene in S.pneumoniae R6 = spr0475; identified by match to protein family HMM PF01636 YP_815983.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine YP_815984.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins YP_815985.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination YP_815986.1 equivalent gene in S.pneumoniae TIGR4 = SP0554; equivalent gene in S.pneumoniae R6 = spr0479; identified by match to protein family HMM PF04296 YP_815987.1 equivalent gene in S.pneumoniae TIGR4 = SP0555; equivalent gene in S.pneumoniae R6 = spr0480; identified by match to protein family HMM PF01248 YP_815988.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex YP_815989.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock YP_815990.1 equivalent gene in S.pneumoniae TIGR4 = SP0558; equivalent gene in S.pneumoniae R6 = spr0483 YP_815991.1 equivalent gene in S.pneumoniae R6 = spr0484 YP_815993.1 equivalent gene in S.pneumoniae TIGR4 = SP0561; equivalent gene in S.pneumoniae R6 = spr0485 YP_815994.1 equivalent gene in S.pneumoniae TIGR4 = SP0562; equivalent gene in S.pneumoniae R6 = spr0486; identified by match to protein family HMM PF01814; match to protein family HMM PF04282 YP_815995.1 equivalent gene in S.pneumoniae TIGR4 = SP0563; equivalent gene in S.pneumoniae R6 = spr0487 YP_815996.1 equivalent gene in S.pneumoniae TIGR4 = SP0564; equivalent gene in S.pneumoniae R6 = spr0488 YP_815997.1 equivalent gene in S.pneumoniae TIGR4 = SP0565; equivalent gene in S.pneumoniae R6 = spr0489 YP_815998.1 equivalent gene in S.pneumoniae R6 = spr0490; identified by match to protein family HMM PF00583 YP_815999.1 equivalent gene in S.pneumoniae R6 = spr0491 YP_816000.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain YP_816001.1 equivalent gene in S.pneumoniae R6 = spr0493 YP_816002.1 equivalent gene in S.pneumoniae TIGR4 = SP0571; equivalent gene in S.pneumoniae R6 = spr0494; identified by match to protein family HMM PF02661 YP_816003.1 equivalent gene in S.pneumoniae TIGR4 = SP1596; equivalent gene in S.pneumoniae R6 = spr0498 YP_816004.1 equivalent gene in S.pneumoniae TIGR4 = SP0576; equivalent gene in S.pneumoniae R6 = spr0504; identified by match to protein family HMM PF00874; match to protein family HMM PF03123 YP_816005.1 equivalent gene in S.pneumoniae TIGR4 = SP0577; equivalent gene in S.pneumoniae R6 = spr0505; identified by match to protein family HMM PF00358; match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00830; match to protein family HMM TIGR01995 YP_816006.1 equivalent gene in S.pneumoniae TIGR4 = SP0578; equivalent gene in S.pneumoniae R6 = spr0506; identified by match to protein family HMM PF00232 YP_816007.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily YP_816008.1 equivalent gene in S.pneumoniae TIGR4 = SP0580; equivalent gene in S.pneumoniae R6 = spr0508; identified by match to protein family HMM PF00583 YP_816009.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily YP_816010.1 equivalent gene in S.pneumoniae TIGR4 = SP0582; equivalent gene in S.pneumoniae R6 = spr0510; identified by match to protein family HMM PF03372 YP_816011.1 equivalent gene in S.pneumoniae TIGR4 = SP1144; equivalent gene in S.pneumoniae R6 = spr0513; identified by match to protein family HMM PF01381 YP_816012.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine YP_816013.1 equivalent gene in S.pneumoniae TIGR4 = SP0586; equivalent gene in S.pneumoniae R6 = spr0515; identified by match to protein family HMM PF02219; match to protein family HMM TIGR00676 YP_816014.1 equivalent gene in S.pneumoniae TIGR4 = SP0588; equivalent gene in S.pneumoniae R6 = spr0516; identified by match to protein family HMM PF00013; match to protein family HMM PF00575; match to protein family HMM PF01138; match to protein family HMM PF03725; match to protein family HMM PF03726 YP_816015.1 equivalent gene in S.pneumoniae TIGR4 = SP0589; equivalent gene in S.pneumoniae R6 = spr0517; identified by match to protein family HMM TIGR01172 YP_816016.1 equivalent gene in S.pneumoniae TIGR4 = SP0590; equivalent gene in S.pneumoniae R6 = spr0518; identified by match to protein family HMM PF00583 YP_816017.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA YP_816018.1 equivalent gene in S.pneumoniae TIGR4 = SP0592; equivalent gene in S.pneumoniae R6 = spr0520 YP_816019.1 equivalent gene in S.pneumoniae TIGR4 = SP0593; equivalent gene in S.pneumoniae R6 = spr0521 YP_816020.1 equivalent gene in S.pneumoniae TIGR4 = SP0595; equivalent gene in S.pneumoniae R6 = spr0522 YP_816021.1 equivalent gene in S.pneumoniae TIGR4 = SP0596 YP_816022.1 equivalent gene in S.pneumoniae R6 = spr0523 YP_816023.1 equivalent gene in S.pneumoniae TIGR4 = SP0599; equivalent gene in S.pneumoniae R6 = spr0524; identified by match to protein family HMM PF02687 YP_816024.1 equivalent gene in S.pneumoniae TIGR4 = SP0600; equivalent gene in S.pneumoniae R6 = spr0525; identified by match to protein family HMM PF00005 YP_816025.1 equivalent gene in S.pneumoniae TIGR4 = SP0601; equivalent gene in S.pneumoniae R6 = spr0526; identified by match to protein family HMM PF02687 YP_816026.1 equivalent gene in S.pneumoniae TIGR4 = SP0603; equivalent gene in S.pneumoniae R6 = spr0528; identified by match to protein family HMM PF00072; match to protein family HMM PF00486 YP_816027.1 equivalent gene in S.pneumoniae TIGR4 = SP0604; equivalent gene in S.pneumoniae R6 = spr0529; identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518 YP_816028.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate YP_816029.1 equivalent gene in S.pneumoniae TIGR4 = SP0606; equivalent gene in S.pneumoniae R6 = spr0531; identified by match to protein family HMM PF00175; match to protein family HMM PF00970; match to protein family HMM PF01794 YP_816030.1 equivalent gene in S.pneumoniae TIGR4 = SP0607; equivalent gene in S.pneumoniae R6 = spr0532; identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726 YP_816031.1 equivalent gene in S.pneumoniae TIGR4 = SP0608; equivalent gene in S.pneumoniae R6 = spr0533; identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726 YP_816032.1 equivalent gene in S.pneumoniae TIGR4 = SP0609; equivalent gene in S.pneumoniae R6 = spr0534; identified by match to protein family HMM PF00497 YP_816033.1 equivalent gene in S.pneumoniae TIGR4 = SP0611; equivalent gene in S.pneumoniae R6 = spr0537; identified by match to protein family HMM PF01368; match to protein family HMM PF02272; match to protein family HMM TIGR00644 YP_816034.1 equivalent gene in S.pneumoniae TIGR4 = SP0613; equivalent gene in S.pneumoniae R6 = spr0538; identified by match to protein family HMM PF00753; match to protein family HMM PF07521 YP_816035.1 equivalent gene in S.pneumoniae TIGR4 = SP0614; equivalent gene in S.pneumoniae R6 = spr0539; identified by match to protein family HMM PF00756 YP_816036.1 equivalent gene in S.pneumoniae TIGR4 = SP0615; equivalent gene in S.pneumoniae R6 = spr0540; identified by match to protein family HMM PF02388 YP_816037.1 equivalent gene in S.pneumoniae TIGR4 = SP0616; equivalent gene in S.pneumoniae R6 = spr0541; identified by match to protein family HMM PF02388 YP_816038.1 equivalent gene in S.pneumoniae TIGR4 = SP0617; equivalent gene in S.pneumoniae R6 = spr0542; identified by match to protein family HMM PF00413 YP_816039.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision YP_816040.1 equivalent gene in S.pneumoniae TIGR4 = SP0619; equivalent gene in S.pneumoniae R6 = spr0544; identified by match to protein family HMM PF00149 YP_816041.1 equivalent gene in S.pneumoniae TIGR4 = SP0620; equivalent gene in S.pneumoniae R6 = spr0545; identified by match to protein family HMM PF00497 YP_816042.1 equivalent gene in S.pneumoniae TIGR4 = SP0622; equivalent gene in S.pneumoniae R6 = spr0546; identified by match to protein family HMM PF00881 YP_816043.1 divalent metal ion-dependent extracellular dipeptidase; able to hydrolyze a broad range of dipeptides but no tri-, tetra-, or larger oligopeptides; differences in the amino acid specificity of the cleavage site varies between species; similar to succinyl-diaminopimelate desuccinylases YP_816044.1 equivalent gene in S.pneumoniae TIGR4 = SP0624; equivalent gene in S.pneumoniae R6 = spr0548; identified by match to protein family HMM PF03167 YP_816045.1 equivalent gene in S.pneumoniae R6 = spr0549 YP_816046.1 equivalent gene in S.pneumoniae R6 = spr0550 YP_816047.1 equivalent gene in S.pneumoniae TIGR4 = SP0626; equivalent gene in S.pneumoniae R6 = spr0551; identified by match to protein family HMM PF05525; match to protein family HMM TIGR00796 YP_816048.1 equivalent gene in S.pneumoniae TIGR4 = SP0627; equivalent gene in S.pneumoniae R6 = spr0552; identified by match to protein family HMM PF05343 YP_816049.1 equivalent gene in S.pneumoniae TIGR4 = SP0628; equivalent gene in S.pneumoniae R6 = spr0553; identified by match to protein family HMM PF01230 YP_816050.1 equivalent gene in S.pneumoniae TIGR4 = SP0629; equivalent gene in S.pneumoniae R6 = spr0554; identified by match to protein family HMM PF02557 YP_816051.1 binds directly to 23S ribosomal RNA YP_816052.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA YP_816054.1 equivalent gene in S.pneumoniae TIGR4 = SP0633 YP_816055.1 equivalent gene in S.pneumoniae TIGR4 = SP0636; equivalent gene in S.pneumoniae R6 = spr0557; identified by match to protein family HMM PF00005 YP_816056.1 equivalent gene in S.pneumoniae TIGR4 = SP0637; equivalent gene in S.pneumoniae R6 = spr0558; identified by match to protein family HMM PF06182 YP_816057.1 equivalent gene in S.pneumoniae TIGR4 = SP0638; equivalent gene in S.pneumoniae R6 = spr0559; identified by match to protein family HMM PF06182 YP_816058.1 equivalent gene in S.pneumoniae TIGR4 = SP0641; equivalent gene in S.pneumoniae R6 = spr0561; identified by match to protein family HMM PF00082; match to protein family HMM PF00746; match to protein family HMM PF02225; match to protein family HMM PF06280; match to protein family HMM TIGR01167 YP_816059.1 equivalent gene in S.pneumoniae TIGR4 = SP0645; equivalent gene in S.pneumoniae R6 = spr0562; identified by match to protein family HMM PF00359 YP_816060.1 equivalent gene in S.pneumoniae TIGR4 = SP0646; equivalent gene in S.pneumoniae R6 = spr0563 YP_816061.1 equivalent gene in S.pneumoniae TIGR4 = SP0647; equivalent gene in S.pneumoniae R6 = spr0564; identified by match to protein family HMM PF03611 YP_816062.1 equivalent gene in S.pneumoniae TIGR4 = SP0648; equivalent gene in S.pneumoniae R6 = spr0565; identified by match to protein family HMM PF00703; match to protein family HMM PF00746; match to protein family HMM PF02836; match to protein family HMM PF02837; match to protein family HMM PF04650; match to protein family HMM PF07501; match to protein family HMM PF07532; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168 YP_816063.1 equivalent gene in S.pneumoniae TIGR4 = SP0650; equivalent gene in S.pneumoniae R6 = spr0568 YP_816064.1 equivalent gene in S.pneumoniae R6 = spr0569 YP_816065.1 equivalent gene in S.pneumoniae R6 = spr0570 YP_816066.1 equivalent gene in S.pneumoniae TIGR4 = SP0652; equivalent gene in S.pneumoniae R6 = spr0571; identified by match to protein family HMM PF06962 YP_816067.1 equivalent gene in S.pneumoniae TIGR4 = SP0653; equivalent gene in S.pneumoniae R6 = spr0572 YP_816068.1 equivalent gene in S.pneumoniae TIGR4 = SP0655; equivalent gene in S.pneumoniae R6 = spr0573; identified by match to protein family HMM PF00999 YP_816069.1 equivalent gene in S.pneumoniae TIGR4 = SP0657; equivalent gene in S.pneumoniae R6 = spr0574; identified by match to protein family HMM PF03631 YP_816070.1 equivalent gene in S.pneumoniae TIGR4 = SP0658; equivalent gene in S.pneumoniae R6 = spr0575; identified by match to protein family HMM PF02683 YP_816071.1 equivalent gene in S.pneumoniae TIGR4 = SP0659; equivalent gene in S.pneumoniae R6 = spr0576 YP_816072.1 equivalent gene in S.pneumoniae TIGR4 = SP0660; equivalent gene in S.pneumoniae R6 = spr0577; identified by match to protein family HMM PF01625; match to protein family HMM PF01641; match to protein family HMM TIGR00357; match to protein family HMM TIGR00401 YP_816073.1 equivalent gene in S.pneumoniae TIGR4 = SP0661; equivalent gene in S.pneumoniae R6 = spr0578; identified by match to protein family HMM PF00072; match to protein family HMM PF00165 YP_816074.1 equivalent gene in S.pneumoniae TIGR4 = SP0662; equivalent gene in S.pneumoniae R6 = spr0579; identified by match to protein family HMM PF00672; match to protein family HMM PF02518; match to protein family HMM PF02743; match to protein family HMM PF06580 YP_816075.1 equivalent gene in S.pneumoniae TIGR4 = SP0663; equivalent gene in S.pneumoniae R6 = spr0580; identified by match to protein family HMM PF04260; match to protein family HMM TIGR01440 YP_816076.1 equivalent gene in S.pneumoniae R6 = spr0581; identified by match to protein family HMM PF00746; match to protein family HMM PF05342; match to protein family HMM PF07501; match to protein family HMM PF07580; match to protein family HMM TIGR01167 YP_816077.1 equivalent gene in S.pneumoniae TIGR4 = SP0665; equivalent gene in S.pneumoniae R6 = spr0582; identified by match to protein family HMM PF00425; match to protein family HMM TIGR00553 YP_816078.1 equivalent gene in S.pneumoniae TIGR4 = SP0667; equivalent gene in S.pneumoniae R6 = spr0583; identified by match to protein family HMM PF01473; match to protein family HMM PF05901; match to protein family HMM PF07553 YP_816079.1 equivalent gene in S.pneumoniae TIGR4 = SP0668; equivalent gene in S.pneumoniae R6 = spr0584; identified by match to protein family HMM PF00480; match to protein family HMM TIGR00744 YP_816080.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived YP_816081.1 equivalent gene in S.pneumoniae TIGR4 = SP0670; equivalent gene in S.pneumoniae R6 = spr0586 YP_816082.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity YP_816083.1 equivalent gene in S.pneumoniae TIGR4 = SP0672; equivalent gene in S.pneumoniae R6 = spr0589; identified by match to protein family HMM PF01926; match to protein family HMM TIGR00231 YP_816084.1 equivalent gene in S.pneumoniae TIGR4 = SP0673; equivalent gene in S.pneumoniae R6 = spr0590 YP_816085.1 member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions YP_816086.1 equivalent gene in S.pneumoniae TIGR4 = SP0675; equivalent gene in S.pneumoniae R6 = spr0592; identified by match to protein family HMM PF00106 YP_816087.1 equivalent gene in S.pneumoniae TIGR4 = SP0676; equivalent gene in S.pneumoniae R6 = spr0593; identified by match to protein family HMM PF00126 YP_816088.1 equivalent gene in S.pneumoniae TIGR4 = SP0677; equivalent gene in S.pneumoniae R6 = spr0594; identified by match to protein family HMM PF06014 YP_816089.1 equivalent gene in S.pneumoniae TIGR4 = SP0678; equivalent gene in S.pneumoniae R6 = spr0595; identified by match to protein family HMM PF00581 YP_816090.1 equivalent gene in S.pneumoniae TIGR4 = SP0679; equivalent gene in S.pneumoniae R6 = spr0596 YP_816091.1 equivalent gene in S.pneumoniae TIGR4 = SP0680; equivalent gene in S.pneumoniae R6 = spr0597; identified by match to protein family HMM PF00849; match to protein family HMM PF01479; match to protein family HMM TIGR00093 YP_816092.1 equivalent gene in S.pneumoniae TIGR4 = SP0681; equivalent gene in S.pneumoniae R6 = spr0598; identified by match to protein family HMM PF00009; match to protein family HMM PF00679; match to protein family HMM PF03144; match to protein family HMM TIGR00231; match to protein family HMM TIGR01394 YP_816093.1 equivalent gene in S.pneumoniae TIGR4 = SP0682; equivalent gene in S.pneumoniae R6 = spr0599 YP_816094.1 equivalent gene in S.pneumoniae R6 = spr0600; identified by match to protein family HMM TIGR01653 YP_816095.1 equivalent gene in S.pneumoniae TIGR4 = SP0686; equivalent gene in S.pneumoniae R6 = spr0601; identified by match to protein family HMM PF07242; match to protein family HMM TIGR01654 YP_816096.1 equivalent gene in S.pneumoniae TIGR4 = SP0687; equivalent gene in S.pneumoniae R6 = spr0602; identified by match to protein family HMM PF00005 YP_816097.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation YP_816098.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis YP_816099.1 equivalent gene in S.pneumoniae TIGR4 = SP0690; equivalent gene in S.pneumoniae R6 = spr0605; identified by match to protein family HMM PF03799 YP_816100.1 equivalent gene in S.pneumoniae TIGR4 = SP0691; identified by Glimmer2 YP_816101.1 equivalent gene in S.pneumoniae TIGR4 = SP0692 YP_816102.1 equivalent gene in S.pneumoniae TIGR4 = SP0694; equivalent gene in S.pneumoniae R6 = spr0607; identified by match to protein family HMM PF02163 YP_816103.1 equivalent gene in S.pneumoniae TIGR4 = SP0695; equivalent gene in S.pneumoniae R6 = spr0608; identified by match to protein family HMM PF00899 YP_816104.1 equivalent gene in S.pneumoniae TIGR4 = SP0698; equivalent gene in S.pneumoniae R6 = spr0611; identified by match to protein family HMM PF01061 YP_816105.1 type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase YP_816106.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate YP_816107.1 equivalent gene in S.pneumoniae TIGR4 = SP0703; equivalent gene in S.pneumoniae R6 = spr0615 YP_816108.1 equivalent gene in S.pneumoniae TIGR4 = SP0704; equivalent gene in S.pneumoniae R6 = spr0616 YP_816109.1 equivalent gene in S.pneumoniae TIGR4 = SP0705; equivalent gene in S.pneumoniae R6 = spr0617 YP_816110.1 equivalent gene in S.pneumoniae TIGR4 = SP0706; equivalent gene in S.pneumoniae R6 = spr0618 YP_816111.1 equivalent gene in S.pneumoniae TIGR4 = SP0707; equivalent gene in S.pneumoniae R6 = spr0619; identified by match to protein family HMM PF00005 YP_816112.1 equivalent gene in S.pneumoniae TIGR4 = SP0709; equivalent gene in S.pneumoniae R6 = spr0622; identified by match to protein family HMM PF00005 YP_816113.1 equivalent gene in S.pneumoniae TIGR4 = SP0710; equivalent gene in S.pneumoniae R6 = spr0623; identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726 YP_816114.1 equivalent gene in S.pneumoniae TIGR4 = SP0711; equivalent gene in S.pneumoniae R6 = spr0624; identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726 YP_816115.1 equivalent gene in S.pneumoniae TIGR4 = SP0712; equivalent gene in S.pneumoniae R6 = spr0625 YP_816116.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 YP_816117.1 equivalent gene in S.pneumoniae TIGR4 = SP0715; equivalent gene in S.pneumoniae R6 = spr0627; identified by match to protein family HMM PF01070; match to protein family HMM TIGR02708 YP_816118.1 equivalent gene in S.pneumoniae TIGR4 = SP0716; equivalent gene in S.pneumoniae R6 = spr0628; identified by match to protein family HMM PF03070 YP_816119.1 catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP YP_816120.1 equivalent gene in S.pneumoniae TIGR4 = SP0718; equivalent gene in S.pneumoniae R6 = spr0630; identified by match to protein family HMM PF02581; match to protein family HMM TIGR00693 YP_816121.1 equivalent gene in S.pneumoniae TIGR4 = SP0719; equivalent gene in S.pneumoniae R6 = spr0631 YP_816122.1 equivalent gene in S.pneumoniae TIGR4 = SP0720; equivalent gene in S.pneumoniae R6 = spr0632; identified by match to protein family HMM PF00005 YP_816123.1 equivalent gene in S.pneumoniae TIGR4 = SP0721; equivalent gene in S.pneumoniae R6 = spr0633 YP_816124.1 equivalent gene in S.pneumoniae TIGR4 = SP0722; equivalent gene in S.pneumoniae R6 = spr0634; identified by match to protein family HMM PF03070 YP_816125.1 equivalent gene in S.pneumoniae TIGR4 = SP0723; equivalent gene in S.pneumoniae R6 = spr0635; identified by match to protein family HMM TIGR02359 YP_816126.1 equivalent gene in S.pneumoniae TIGR4 = SP0724; equivalent gene in S.pneumoniae R6 = spr0636; identified by match to protein family HMM PF02110 YP_816127.1 Condenses 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate to form thiamine monophosphate YP_816128.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine YP_816129.1 equivalent gene in S.pneumoniae TIGR4 = SP0727; equivalent gene in S.pneumoniae R6 = spr0639; identified by match to protein family HMM PF03965; match to protein family HMM TIGR02698 YP_816130.1 equivalent gene in S.pneumoniae TIGR4 = SP0728; equivalent gene in S.pneumoniae R6 = spr0640 YP_816131.1 equivalent gene in S.pneumoniae TIGR4 = SP0729; equivalent gene in S.pneumoniae R6 = spr0641; identified by match to protein family HMM PF00122; match to protein family HMM PF00702; match to protein family HMM TIGR01494; match to protein family HMM TIGR01511; match to protein family HMM TIGR01525 YP_816132.1 equivalent gene in S.pneumoniae TIGR4 = SP0730; equivalent gene in S.pneumoniae R6 = spr0642; identified by match to protein family HMM PF00205; match to protein family HMM PF02775; match to protein family HMM PF02776; match to protein family HMM TIGR02720 YP_816133.1 equivalent gene in S.pneumoniae TIGR4 = SP0731; equivalent gene in S.pneumoniae R6 = spr0643; identified by match to protein family HMM PF00903 YP_816134.1 equivalent gene in S.pneumoniae TIGR4 = SP0811; equivalent gene in S.pneumoniae R6 = spr0644 YP_816135.1 equivalent gene in S.pneumoniae TIGR4 = SP1487; equivalent gene in S.pneumoniae R6 = spr0645 YP_816136.1 equivalent gene in S.pneumoniae TIGR4 = SP0736; equivalent gene in S.pneumoniae R6 = spr0647; identified by match to protein family HMM PF01238; match to protein family HMM TIGR00218 YP_816137.1 This gene may encode a frameshift. The COOH end is frameshifted relative to the TIGR4 ortholog. equivalent gene in S.pneumoniae TIGR4 = SP0737; equivalent gene in S.pneumoniae R6 = spr0648; identified by match to protein family HMM PF00209 YP_816138.1 equivalent gene in S.pneumoniae TIGR4 = SP0740; equivalent gene in S.pneumoniae R6 = spr0650; identified by match to protein family HMM PF00293 YP_816139.1 equivalent gene in S.pneumoniae TIGR4 = SP0741; equivalent gene in S.pneumoniae R6 = spr0651; identified by match to protein family HMM PF03486; match to protein family HMM TIGR00275 YP_816140.1 equivalent gene in S.pneumoniae TIGR4 = SP0742; equivalent gene in S.pneumoniae R6 = spr0652; identified by match to protein family HMM PF02645 YP_816141.1 equivalent gene in S.pneumoniae TIGR4 = SP0743; equivalent gene in S.pneumoniae R6 = spr0653; identified by match to protein family HMM PF00440 YP_816142.1 equivalent gene in S.pneumoniae TIGR4 = SP0744; equivalent gene in S.pneumoniae R6 = spr0654; identified by match to protein family HMM PF00383 YP_816143.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate YP_816144.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates YP_816145.1 equivalent gene in S.pneumoniae TIGR4 = SP0748; equivalent gene in S.pneumoniae R6 = spr0657 YP_816146.1 equivalent gene in S.pneumoniae TIGR4 = SP0749; equivalent gene in S.pneumoniae R6 = spr0659; identified by match to protein family HMM PF01094 YP_816147.1 equivalent gene in S.pneumoniae TIGR4 = SP0750; equivalent gene in S.pneumoniae R6 = spr0660; identified by match to protein family HMM PF02653 YP_816148.1 equivalent gene in S.pneumoniae TIGR4 = SP0751; equivalent gene in S.pneumoniae R6 = spr0661; identified by match to protein family HMM PF02653 YP_816149.1 equivalent gene in S.pneumoniae TIGR4 = SP0752; equivalent gene in S.pneumoniae R6 = spr0662; identified by match to protein family HMM PF00005 YP_816150.1 equivalent gene in S.pneumoniae TIGR4 = SP0753; equivalent gene in S.pneumoniae R6 = spr0663; identified by match to protein family HMM PF00005 YP_816151.1 equivalent gene in S.pneumoniae TIGR4 = SP0754; equivalent gene in S.pneumoniae R6 = spr0664; identified by match to protein family HMM PF00571; match to protein family HMM PF01842 YP_816152.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1 YP_816153.1 equivalent gene in S.pneumoniae TIGR4 = SP0756; equivalent gene in S.pneumoniae R6 = spr0666; identified by match to protein family HMM PF00005; match to protein family HMM TIGR02673 YP_816154.1 equivalent gene in S.pneumoniae TIGR4 = SP0757; equivalent gene in S.pneumoniae R6 = spr0667; identified by match to protein family HMM PF02687 YP_816155.1 equivalent gene in S.pneumoniae TIGR4 = SP0758; equivalent gene in S.pneumoniae R6 = spr0668; identified by match to protein family HMM PF00358; match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826; match to protein family HMM TIGR00830; match to protein family HMM TIGR02003 YP_816156.1 equivalent gene in S.pneumoniae TIGR4 = SP0760; equivalent gene in S.pneumoniae R6 = spr0669; identified by match to protein family HMM PF03372 YP_816157.1 equivalent gene in S.pneumoniae TIGR4 = SP0761; equivalent gene in S.pneumoniae R6 = spr0670; identified by match to protein family HMM PF00270; match to protein family HMM PF00271 YP_816158.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase YP_816159.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; subclass 1A is a dimer formed by two identical PyrD subunits each containing an FMN group YP_816160.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA YP_816161.1 equivalent gene in S.pneumoniae TIGR4 = SP0766; equivalent gene in S.pneumoniae R6 = spr0674; identified by match to protein family HMM PF00081; match to protein family HMM PF02777 YP_816162.1 equivalent gene in S.pneumoniae TIGR4 = SP0767; equivalent gene in S.pneumoniae R6 = spr0675; identified by match to protein family HMM PF06265 YP_816163.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance YP_816164.1 equivalent gene in S.pneumoniae R6 = spr0677; identified by match to protein family HMM PF04892 YP_816165.1 equivalent gene in S.pneumoniae TIGR4 = SP0770; equivalent gene in S.pneumoniae R6 = spr0678; identified by match to protein family HMM PF00005 YP_816166.1 equivalent gene in S.pneumoniae TIGR4 = SP0771; equivalent gene in S.pneumoniae R6 = spr0679; identified by match to protein family HMM PF00160 YP_816167.1 equivalent gene in S.pneumoniae TIGR4 = SP0772; equivalent gene in S.pneumoniae R6 = spr0680 YP_816168.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity YP_816169.1 equivalent gene in S.pneumoniae TIGR4 = SP0776; equivalent gene in S.pneumoniae R6 = spr0683 YP_816170.1 equivalent gene in S.pneumoniae TIGR4 = SP0777; equivalent gene in S.pneumoniae R6 = spr0684 YP_816171.1 equivalent gene in S.pneumoniae TIGR4 = SP0777; equivalent gene in S.pneumoniae R6 = spr0685 YP_816172.1 Essential for efficient processing of 16S rRNA YP_816173.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA YP_816174.1 equivalent gene in S.pneumoniae TIGR4 = SP0780; equivalent gene in S.pneumoniae R6 = spr0688; identified by match to protein family HMM PF03477 YP_816175.1 equivalent gene in S.pneumoniae TIGR4 = SP0781; equivalent gene in S.pneumoniae R6 = spr0689 YP_816176.1 equivalent gene in S.pneumoniae TIGR4 = SP0782; equivalent gene in S.pneumoniae R6 = spr0690 YP_816178.1 equivalent gene in S.pneumoniae TIGR4 = SP0783; equivalent gene in S.pneumoniae R6 = spr0691; identified by match to protein family HMM PF02632 YP_816179.1 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense YP_816180.1 equivalent gene in S.pneumoniae TIGR4 = SP0785; equivalent gene in S.pneumoniae R6 = spr0693; identified by match to protein family HMM TIGR01730 YP_816181.1 equivalent gene in S.pneumoniae TIGR4 = SP0786; equivalent gene in S.pneumoniae R6 = spr0694; identified by match to protein family HMM PF00005 YP_816182.1 equivalent gene in S.pneumoniae TIGR4 = SP0787; equivalent gene in S.pneumoniae R6 = spr0695; identified by match to protein family HMM PF02687 YP_816183.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content YP_816185.1 equivalent gene in S.pneumoniae TIGR4 = SP0789; equivalent gene in S.pneumoniae R6 = spr0697; identified by match to protein family HMM PF03551 YP_816186.1 equivalent gene in S.pneumoniae TIGR4 = SP0790; equivalent gene in S.pneumoniae R6 = spr0698 YP_816187.1 equivalent gene in S.pneumoniae TIGR4 = SP0791; equivalent gene in S.pneumoniae R6 = spr0699; identified by match to protein family HMM PF00248 YP_816188.1 equivalent gene in S.pneumoniae TIGR4 = SP0792; equivalent gene in S.pneumoniae R6 = spr0700 YP_816189.1 Catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_816190.1 equivalent gene in S.pneumoniae TIGR4 = SP0794; equivalent gene in S.pneumoniae R6 = spr0702; identified by match to protein family HMM PF00293 YP_816191.1 equivalent gene in S.pneumoniae R6 = spr0703; identified by match to protein family HMM PF00583 YP_816192.1 equivalent gene in S.pneumoniae TIGR4 = SP0795; equivalent gene in S.pneumoniae R6 = spr0704; identified by match to protein family HMM PF02896 YP_816193.1 equivalent gene in S.pneumoniae TIGR4 = SP0796; equivalent gene in S.pneumoniae R6 = spr0705; identified by match to protein family HMM PF06171 YP_816194.1 equivalent gene in S.pneumoniae TIGR4 = SP0797; equivalent gene in S.pneumoniae R6 = spr0706; identified by match to protein family HMM PF01433 YP_816195.1 equivalent gene in S.pneumoniae TIGR4 = SP0798; equivalent gene in S.pneumoniae R6 = spr0707; identified by match to protein family HMM PF00072; match to protein family HMM PF00486 YP_816196.1 equivalent gene in S.pneumoniae TIGR4 = SP0799; equivalent gene in S.pneumoniae R6 = spr0708; identified by match to protein family HMM PF00512; match to protein family HMM PF02518 YP_816197.1 equivalent gene in S.pneumoniae TIGR4 = SP0800; equivalent gene in S.pneumoniae R6 = spr0709 YP_816198.1 equivalent gene in S.pneumoniae TIGR4 = SP0801; equivalent gene in S.pneumoniae R6 = spr0710; identified by match to protein family HMM PF01136 YP_816199.1 unwinds DNA YP_816200.1 equivalent gene in S.pneumoniae TIGR4 = SP0803; equivalent gene in S.pneumoniae R6 = spr0712; identified by match to protein family HMM PF01098 YP_816201.1 equivalent gene in S.pneumoniae TIGR4 = SP0804; equivalent gene in S.pneumoniae R6 = spr0713; identified by match to protein family HMM PF01965; match to protein family HMM TIGR01383 YP_816202.1 equivalent gene in S.pneumoniae TIGR4 = SP0805; equivalent gene in S.pneumoniae R6 = spr0714; identified by match to protein family HMM PF00702; match to protein family HMM TIGR01549 YP_816203.1 negatively supercoils closed circular double-stranded DNA YP_816204.1 acts to negatively regulates ftsZ ring formation by modulating the frequency and position of the ftsZ ring formation YP_816205.1 equivalent gene in S.pneumoniae TIGR4 = SP1487; equivalent gene in S.pneumoniae R6 = spr0717 YP_816206.1 equivalent gene in S.pneumoniae TIGR4 = SP0811; equivalent gene in S.pneumoniae R6 = spr0718 YP_816207.1 equivalent gene in S.pneumoniae TIGR4 = SP0816; equivalent gene in S.pneumoniae R6 = spr0720 YP_816208.1 equivalent gene in S.pneumoniae TIGR4 = SP0817; equivalent gene in S.pneumoniae R6 = spr0721; identified by match to protein family HMM PF00293 YP_816209.1 equivalent gene in S.pneumoniae TIGR4 = SP0299; equivalent gene in S.pneumoniae R6 = spr0722 In TIGR4 this gene is annotated as a truncation; however in R6 there are numerous near perfect copies as well as copies with a slightly longer version with a different end that is not present in either R6 or TIGR4 This indicates it may still function as a transposase; identified by match to protein family HMM PF01710 YP_816210.1 equivalent gene in S.pneumoniae TIGR4 = SP0820; equivalent gene in S.pneumoniae R6 = spr0725; identified by match to protein family HMM PF00004; match to protein family HMM PF02151; match to protein family HMM PF07724; match to protein family HMM PF07728 YP_816211.1 equivalent gene in S.pneumoniae TIGR4 = SP0822; equivalent gene in S.pneumoniae R6 = spr0726 YP_816212.1 equivalent gene in S.pneumoniae TIGR4 = SP0823; equivalent gene in S.pneumoniae R6 = spr0727; identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726 YP_816213.1 equivalent gene in S.pneumoniae TIGR4 = SP0824; equivalent gene in S.pneumoniae R6 = spr0728; identified by match to protein family HMM PF00005 YP_816214.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate YP_816215.1 equivalent gene in S.pneumoniae R6 = spr0730; identified by match to protein family HMM PF01256; match to protein family HMM TIGR00196; similar to the C-terminus of Escherichia coli YjeF YP_816216.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway YP_816217.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose YP_816218.1 catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation YP_816219.1 equivalent gene in S.pneumoniae TIGR4 = SP0833; equivalent gene in S.pneumoniae R6 = spr0735 YP_816220.1 equivalent gene in S.pneumoniae TIGR4 = SP0833; equivalent gene in S.pneumoniae R6 = spr0736 YP_816221.1 equivalent gene in S.pneumoniae TIGR4 = SP0834; equivalent gene in S.pneumoniae R6 = spr0737 YP_816222.1 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate YP_816223.1 equivalent gene in S.pneumoniae TIGR4 = SP0837; equivalent gene in S.pneumoniae R6 = spr0739 YP_816224.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase YP_816225.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis YP_816226.1 equivalent gene in S.pneumoniae TIGR4 = SP0840; equivalent gene in S.pneumoniae R6 = spr0742 YP_816227.1 equivalent gene in S.pneumoniae TIGR4 = SP0841; equivalent gene in S.pneumoniae R6 = spr0743; identified by match to protein family HMM PF05175 YP_816228.1 Catalyzes the reversible phosphorolysis of pyrimidines in the nucleotide synthesis salvage pathway YP_816229.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate YP_816230.1 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis YP_816231.1 equivalent gene in S.pneumoniae TIGR4 = SP0845; equivalent gene in S.pneumoniae R6 = spr0747; identified by match to protein family HMM PF02608 YP_816232.1 equivalent gene in S.pneumoniae TIGR4 = SP0846; equivalent gene in S.pneumoniae R6 = spr0748; identified by match to protein family HMM PF00005 YP_816233.1 equivalent gene in S.pneumoniae TIGR4 = SP0847; equivalent gene in S.pneumoniae R6 = spr0749; identified by match to protein family HMM PF02653 YP_816234.1 equivalent gene in S.pneumoniae TIGR4 = SP0848; equivalent gene in S.pneumoniae R6 = spr0750; identified by match to protein family HMM PF02653 YP_816235.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX YP_816236.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_816237.1 equivalent gene in S.pneumoniae TIGR4 = SP0854 YP_816238.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_816239.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids YP_816240.1 equivalent gene in S.pneumoniae R6 = spr0759 YP_816241.1 equivalent gene in S.pneumoniae TIGR4 = SP0858; equivalent gene in S.pneumoniae R6 = spr0760; identified by match to protein family HMM PF06149 YP_816242.1 equivalent gene in S.pneumoniae TIGR4 = SP0859; equivalent gene in S.pneumoniae R6 = spr0761; identified by match to protein family HMM PF06166 YP_816243.1 catalyzes the removal of 5-oxoproline from various penultimate amino acid residues except L-proline YP_816244.1 equivalent gene in S.pneumoniae TIGR4 = SP0861; equivalent gene in S.pneumoniae R6 = spr0763 YP_816245.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins YP_816246.1 equivalent gene in S.pneumoniae TIGR4 = SP0864; equivalent gene in S.pneumoniae R6 = spr0768 YP_816247.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA YP_816248.1 equivalent gene in S.pneumoniae TIGR4 = SP0866; equivalent gene in S.pneumoniae R6 = spr0770 YP_816249.1 equivalent gene in S.pneumoniae TIGR4 = SP0867; equivalent gene in S.pneumoniae R6 = spr0771; identified by match to protein family HMM PF00005; match to protein family HMM TIGR01978 YP_816250.1 equivalent gene in S.pneumoniae TIGR4 = SP0868; equivalent gene in S.pneumoniae R6 = spr0772; identified by match to protein family HMM PF01458; match to protein family HMM TIGR01981 YP_816251.1 equivalent gene in S.pneumoniae TIGR4 = SP0869; equivalent gene in S.pneumoniae R6 = spr0773; identified by match to protein family HMM PF00266; match to protein family HMM PF01212; match to protein family HMM TIGR01979 YP_816252.1 equivalent gene in S.pneumoniae TIGR4 = SP0870; equivalent gene in S.pneumoniae R6 = spr0774; identified by match to protein family HMM PF01592; match to protein family HMM TIGR01994 YP_816253.1 equivalent gene in S.pneumoniae TIGR4 = SP0871; equivalent gene in S.pneumoniae R6 = spr0775; identified by match to protein family HMM PF01458; match to protein family HMM TIGR01980 YP_816254.1 equivalent gene in S.pneumoniae TIGR4 = SP0872; equivalent gene in S.pneumoniae R6 = spr0776; identified by match to protein family HMM PF00768; match to protein family HMM PF07943 YP_816255.1 equivalent gene in S.pneumoniae TIGR4 = SP0873; equivalent gene in S.pneumoniae R6 = spr0777; identified by match to protein family HMM PF01594 YP_816256.1 equivalent gene in S.pneumoniae TIGR4 = SP0875; equivalent gene in S.pneumoniae R6 = spr0778; identified by match to protein family HMM PF00455; match to protein family HMM PF08220 YP_816257.1 equivalent gene in S.pneumoniae TIGR4 = SP0876; equivalent gene in S.pneumoniae R6 = spr0779; identified by match to protein family HMM PF00294 YP_816258.1 equivalent gene in S.pneumoniae TIGR4 = SP0877; equivalent gene in S.pneumoniae R6 = spr0780; identified by match to protein family HMM PF00359; match to protein family HMM PF02378; match to protein family HMM PF02379; match to protein family HMM TIGR00829; match to protein family HMM TIGR00848; match to protein family HMM TIGR01427 YP_816259.1 equivalent gene in S.pneumoniae TIGR4 = SP0878; equivalent gene in S.pneumoniae R6 = spr0781; identified by match to protein family HMM PF01580 YP_816260.1 equivalent gene in S.pneumoniae TIGR4 = SP0879; equivalent gene in S.pneumoniae R6 = spr0782 YP_816261.1 equivalent gene in S.pneumoniae TIGR4 = SP0880; equivalent gene in S.pneumoniae R6 = spr0783; identified by match to protein family HMM PF00266 YP_816262.1 Required for the synthesis of the thiazole moiety YP_816263.1 equivalent gene in S.pneumoniae TIGR4 = SP0882; equivalent gene in S.pneumoniae R6 = spr0785; identified by match to protein family HMM PF00756 YP_816264.1 equivalent gene in S.pneumoniae TIGR4 = SP0883; equivalent gene in S.pneumoniae R6 = spr0786 YP_816265.1 equivalent gene in S.pneumoniae TIGR4 = SP0884; equivalent gene in S.pneumoniae R6 = spr0788 YP_816266.1 equivalent gene in S.pneumoniae TIGR4 = SP0885; equivalent gene in S.pneumoniae R6 = spr0789 YP_816267.1 equivalent gene in S.pneumoniae TIGR4 = SP0886; equivalent gene in S.pneumoniae R6 = spr0790; identified by match to protein family HMM PF02384 YP_816268.1 equivalent gene in S.pneumoniae TIGR4 = SP0887; equivalent gene in S.pneumoniae R6 = spr0791; identified by match to protein family HMM PF01420 YP_816269.1 equivalent gene in S.pneumoniae TIGR4 = SP0892; equivalent gene in S.pneumoniae R6 = spr0792; identified by match to protein family HMM PF00270; match to protein family HMM PF00271; match to protein family HMM PF04313; match to protein family HMM PF04851 YP_816271.1 equivalent gene in S.pneumoniae TIGR4 = SP0893; equivalent gene in S.pneumoniae R6 = spr0793; identified by match to protein family HMM PF01316; match to protein family HMM PF02863 YP_816272.1 catalyzes the removal of N-terminal dipeptides when proline is the penultimate residue YP_816273.1 Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. Proposed to be responsible for the synthesis of the lagging strand. In the low GC gram positive bacteria this enzyme is less processive and more error prone than its counterpart in other bacteria. YP_816274.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis YP_816275.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_816276.1 equivalent gene in S.pneumoniae R6 = spr0798 YP_816277.1 equivalent gene in S.pneumoniae TIGR4 = SP0899; equivalent gene in S.pneumoniae R6 = spr0799 YP_816278.1 equivalent gene in S.pneumoniae R6 = spr0800 YP_816279.1 equivalent gene in S.pneumoniae TIGR4 = SP0901; equivalent gene in S.pneumoniae R6 = spr0802 YP_816280.1 equivalent gene in S.pneumoniae R6 = spr0803 YP_816281.1 equivalent gene in S.pneumoniae TIGR4 = SP0904; equivalent gene in S.pneumoniae R6 = spr0804 YP_816282.1 equivalent gene in S.pneumoniae TIGR4 = SP0905; equivalent gene in S.pneumoniae R6 = spr0805; identified by match to protein family HMM PF03773 YP_816283.1 equivalent gene in S.pneumoniae TIGR4 = SP0906 YP_816284.1 equivalent gene in S.pneumoniae TIGR4 = SP0907; equivalent gene in S.pneumoniae R6 = spr0806 The TIGR4 equivalent gene has 130 more amino acids than the D39 or R6 genes. YP_816285.1 equivalent gene in S.pneumoniae TIGR4 = SP0907; equivalent gene in S.pneumoniae R6 = spr0807 YP_816286.1 equivalent gene in S.pneumoniae TIGR4 = SP0908; equivalent gene in S.pneumoniae R6 = spr0808; identified by match to protein family HMM PF00575 YP_816287.1 equivalent gene in S.pneumoniae TIGR4 = SP0910; equivalent gene in S.pneumoniae R6 = spr0810; identified by match to protein family HMM PF04024 YP_816288.1 equivalent gene in S.pneumoniae TIGR4 = SP0912; equivalent gene in S.pneumoniae R6 = spr0812; identified by match to protein family HMM PF00005 YP_816289.1 equivalent gene in S.pneumoniae TIGR4 = SP0913; equivalent gene in S.pneumoniae R6 = spr0813; identified by match to protein family HMM PF02687 YP_816290.1 Gene encodes 3 transmembrane regions. equivalent gene in S.pneumoniae TIGR4 = SP0914; equivalent gene in S.pneumoniae R6 spr0814; identified by match to protein family HMM PF01988 YP_816291.1 equivalent gene in S.pneumoniae TIGR4 = SP0915; equivalent gene in S.pneumoniae R6 = spr0815; identified by match to protein family HMM PF00665 YP_816293.1 equivalent gene in S.pneumoniae TIGR4 = SP0916; equivalent gene in S.pneumoniae R6 = spr0816; identified by match to protein family HMM PF00266; match to protein family HMM PF01212; match to protein family HMM PF01276; match to protein family HMM PF03711 YP_816294.1 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine YP_816295.1 equivalent gene in S.pneumoniae TIGR4 = SP0919; equivalent gene in S.pneumoniae R6 = spr0820; identified by match to protein family HMM PF03435 YP_816296.1 equivalent gene in S.pneumoniae TIGR4 = SP0920; equivalent gene in S.pneumoniae R6 = spr0821; identified by match to protein family HMM PF00278; match to protein family HMM TIGR01047 YP_816297.1 agmatine iminohydrolase; catalyzes the formation of carbamoylputrescine from agmatine in the arginine decarboxylase pathway of putrescine biosynthesis YP_816298.1 equivalent gene in S.pneumoniae TIGR4 = SP0922; equivalent gene in S.pneumoniae R6 = spr0823; identified by match to protein family HMM PF00795 YP_816299.1 equivalent gene in S.pneumoniae TIGR4 = SP0923; equivalent gene in S.pneumoniae R6 = spr0824; identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484 YP_816300.1 equivalent gene in S.pneumoniae TIGR4 = SP0925; equivalent gene in S.pneumoniae R6 = spr0826; identified by match to protein family HMM PF02517 YP_816301.1 equivalent gene in S.pneumoniae TIGR4 = SP0927; equivalent gene in S.pneumoniae R6 = spr0828; identified by match to protein family HMM PF00126; match to protein family HMM PF03466 YP_816302.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis YP_816303.1 equivalent gene in S.pneumoniae TIGR4 = SP0929; equivalent gene in S.pneumoniae R6 = spr0830; identified by match to protein family HMM PF00849; match to protein family HMM PF01479; match to protein family HMM TIGR00005 YP_816304.1 equivalent gene in S.pneumoniae TIGR4 = SP0930; equivalent gene in S.pneumoniae R6 = spr0831; identified by match to protein family HMM PF00753; match to protein family HMM PF01473 YP_816305.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis YP_816306.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway YP_816307.1 equivalent gene in S.pneumoniae TIGR4 = SP0933; equivalent gene in S.pneumoniae R6 = spr0834; identified by match to protein family HMM PF01210; match to protein family HMM PF03446; match to protein family HMM PF03807; match to protein family HMM TIGR00112 YP_816308.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP) YP_816309.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA. YP_816310.1 in Bacillus subtilis this protein is involved in the negative regulation of DNA replication initiation; interacts with DnaN and DnaA YP_816311.1 equivalent gene in S.pneumoniae TIGR4 = SP0938; equivalent gene in S.pneumoniae R6 = spr0838; identified by match to protein family HMM PF00590; match to protein family HMM TIGR00096 YP_816312.1 equivalent gene in S.pneumoniae TIGR4 = SP0939; equivalent gene in S.pneumoniae R6 = spr0839; identified by match to protein family HMM PF08020 YP_816313.1 equivalent gene in S.pneumoniae R6 = spr0840; identified by match to protein family HMM PF06970 YP_816314.1 equivalent gene in S.pneumoniae TIGR4 = SP0538; equivalent gene in S.pneumoniae R6 = spr0841; identified by match to protein family HMM PF01609 YP_816315.1 equivalent gene in S.pneumoniae TIGR4 = SP0942; equivalent gene in S.pneumoniae R6 = spr0842 YP_816316.1 TrmFO; Gid; glucose-inhibited division protein; similar to GidA; the gene from Bacillus subtilis encodes a tRNA-methyltransferase that utilizes folate as the carbon donor and bound flavin as reductant; modifies tRNA at position 54 (uridine) of the T-psi loop to form a C5-methyluridine YP_816317.1 Catalyzes the phosphorylation of UMP to UDP YP_816318.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs YP_816319.1 equivalent gene in S.pneumoniae TIGR4 = SP0946; equivalent gene in S.pneumoniae R6 = spr0847 YP_816320.1 equivalent gene in S.pneumoniae TIGR4 = SP0947; equivalent gene in S.pneumoniae R6 = spr0848; identified by match to protein family HMM PF06855 YP_816321.1 equivalent gene in S.pneumoniae TIGR4 = SP0948; equivalent gene in S.pneumoniae R6 = spr0849; identified by match to protein family HMM PF02562 YP_816322.1 equivalent gene in S.pneumoniae TIGR4 = SP0950; equivalent gene in S.pneumoniae R6 = spr0850; identified by match to protein family HMM PF00583 YP_816323.1 equivalent gene in S.pneumoniae TIGR4 = SP0951; equivalent gene in S.pneumoniae R6 = spr0851 YP_816324.1 equivalent gene in S.pneumoniae TIGR4 = SP0953; equivalent gene in S.pneumoniae R6 = spr0855; identified by match to protein family HMM PF00583 YP_816325.1 equivalent gene in S.pneumoniae TIGR4 = SP0954; equivalent gene in S.pneumoniae R6 = spr0856; identified by match to protein family HMM PF00633; match to protein family HMM TIGR00426; match to protein family HMM TIGR01259 YP_816326.1 equivalent gene in S.pneumoniae TIGR4 = SP0955; equivalent gene in S.pneumoniae R6 = spr0857; identified by match to protein family HMM PF03772; match to protein family HMM TIGR00360; match to protein family HMM TIGR00361 YP_816327.1 equivalent gene in S.pneumoniae TIGR4 = SP0957; equivalent gene in S.pneumoniae R6 = spr0859 YP_816328.1 equivalent gene in S.pneumoniae TIGR4 = SP0958; equivalent gene in S.pneumoniae R6 = spr0860 YP_816329.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits YP_816330.1 equivalent gene in S.pneumoniae TIGR4 = SP0960; equivalent gene in S.pneumoniae R6 = spr0862; identified by match to protein family HMM PF01632; match to protein family HMM TIGR00001 YP_816331.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit YP_816332.1 equivalent gene in S.pneumoniae TIGR4 = SP0962; equivalent gene in S.pneumoniae R6 = spr0864; identified by match to protein family HMM PF00903 YP_816333.1 responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the pyrD subunit to the ultimate electron acceptor NAD(+) YP_816334.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway, using a flavin nucleotide as an essential cofactor; subclass 1B is a heterotetramer consisting of two PyrDB subunits, similar to the PyrDA subunits and two PyrK subunits YP_816335.1 equivalent gene in S.pneumoniae R6 = spr0867; identified by match to protein family HMM PF01473; match to protein family HMM PF01832 YP_816336.1 equivalent gene in S.pneumoniae TIGR4 = SP0966; equivalent gene in S.pneumoniae R6 = spr0868; identified by match to protein family HMM PF05670; match to protein family HMM PF05833 YP_816337.1 equivalent gene in S.pneumoniae TIGR4 = SP0967; equivalent gene in S.pneumoniae R6 = spr0869; identified by match to protein family HMM PF02130; match to protein family HMM TIGR00043 YP_816338.1 equivalent gene in S.pneumoniae TIGR4 = SP0968; equivalent gene in S.pneumoniae R6 = spr0870; identified by match to protein family HMM PF01219 YP_816339.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome YP_816340.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases YP_816341.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis YP_816342.1 equivalent gene in S.pneumoniae TIGR4 = SP0972; equivalent gene in S.pneumoniae R6 = spr0875; identified by match to protein family HMM PF07690 YP_816343.1 equivalent gene in S.pneumoniae TIGR4 = SP0974; equivalent gene in S.pneumoniae R6 = spr0877; identified by match to protein family HMM PF03840; match to protein family HMM TIGR00810 YP_816344.1 equivalent gene in S.pneumoniae TIGR4 = SP0975; equivalent gene in S.pneumoniae R6 = spr0878; identified by match to protein family HMM PF00575; match to protein family HMM PF00773; match to protein family HMM PF08206; match to protein family HMM TIGR00358; match to protein family HMM TIGR02063 YP_816345.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation YP_816346.1 with TehA confers resistance to tellurite YP_816347.1 equivalent gene in S.pneumoniae TIGR4 = SP0978; equivalent gene in S.pneumoniae R6 = spr0881; identified by match to protein family HMM PF06054 YP_816348.1 equivalent gene in S.pneumoniae TIGR4 = SP0979; equivalent gene in S.pneumoniae R6 = spr0882; identified by match to protein family HMM PF01432; match to protein family HMM TIGR00181 YP_816349.1 equivalent gene in S.pneumoniae TIGR4 = SP0980; equivalent gene in S.pneumoniae R6 = spr0883; identified by match to protein family HMM PF01596 YP_816350.1 cis/trans isomerase of peptidylprolyl; PPIase; membrane-bound lipoprotein YP_816351.1 equivalent gene in S.pneumoniae TIGR4 = SP1485; equivalent gene in S.pneumoniae R6 = spr0885 YP_816352.1 equivalent gene in S.pneumoniae TIGR4 = SP0984; equivalent gene in S.pneumoniae R6 = spr0887; identified by match to protein family HMM PF00300 YP_816353.1 equivalent gene in S.pneumoniae TIGR4 = SP0985; equivalent gene in S.pneumoniae R6 = spr0888; identified by match to protein family HMM PF04073 YP_816354.1 equivalent gene in S.pneumoniae TIGR4 = SP0986; equivalent gene in S.pneumoniae R6 = spr0889; identified by match to protein family HMM PF04018 YP_816355.1 equivalent gene in S.pneumoniae TIGR4 = SP0987; equivalent gene in S.pneumoniae R6 = spr0890; identified by match to protein family HMM PF01183 YP_816356.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis YP_816357.1 equivalent gene in S.pneumoniae TIGR4 = SP0989; equivalent gene in S.pneumoniae R6 = spr0892; identified by match to protein family HMM PF00293 YP_816358.1 equivalent gene in S.pneumoniae TIGR4 = SP0990; equivalent gene in S.pneumoniae R6 = spr0893 YP_816359.1 enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine YP_816360.1 equivalent gene in S.pneumoniae TIGR4 = SP0992; equivalent gene in S.pneumoniae R6 = spr0895; identified by match to protein family HMM PF04394 YP_816361.1 3'-5' exonuclease of DNA polymerase III YP_816362.1 equivalent gene in S.pneumoniae TIGR4 = SP0994; equivalent gene in S.pneumoniae R6 = spr0897; identified by match to protein family HMM PF03009 YP_816363.1 equivalent gene in S.pneumoniae R6 = spr0899 YP_816364.1 equivalent gene in S.pneumoniae TIGR4 = SP0997; equivalent gene in S.pneumoniae R6 = spr0900 YP_816365.1 equivalent gene in S.pneumoniae TIGR4 = SP0998; equivalent gene in S.pneumoniae R6 = spr0902 YP_816366.1 equivalent gene in S.pneumoniae TIGR4 = SP0999; equivalent gene in S.pneumoniae R6 = spr0903; identified by match to protein family HMM PF02683 YP_816367.1 equivalent gene in S.pneumoniae TIGR4 = SP1000; equivalent gene in S.pneumoniae R6 = spr0904 YP_816368.1 equivalent gene in S.pneumoniae TIGR4 = SP1001; equivalent gene in S.pneumoniae R6 = spr0905; identified by match to protein family HMM PF00324 YP_816369.1 equivalent gene in S.pneumoniae TIGR4 = SP1002; equivalent gene in S.pneumoniae R6 = spr0906; identified by match to protein family HMM PF01297 YP_816370.1 equivalent gene in S.pneumoniae TIGR4 = SP1003; equivalent gene in S.pneumoniae R6 = spr0907; identified by match to protein family HMM PF04270; match to protein family HMM TIGR01363 YP_816371.1 equivalent gene in S.pneumoniae TIGR4 = SP1004; equivalent gene in S.pneumoniae R6 = spr0908; identified by match to protein family HMM PF04270; match to protein family HMM TIGR01363 YP_816372.1 equivalent gene in S.pneumoniae TIGR4 = SP1007; equivalent gene in S.pneumoniae R6 = spr0912 YP_816373.1 catalyzes the release of the N-terminal amino acid from a tripeptide YP_816374.1 equivalent gene in S.pneumoniae TIGR4 = SP1009; equivalent gene in S.pneumoniae R6 = spr0914; identified by match to protein family HMM PF00762; match to protein family HMM TIGR00109 YP_816375.1 equivalent gene in S.pneumoniae TIGR4 = SP1010; equivalent gene in S.pneumoniae R6 = spr0915 Protein encodes a channel which opens in response to a membrane stretch force. Probably serves as an osmotic gauge. Carboxy terminus tends to be more divergent across species with a high degree of sequence conservation found at the N-terminus; identified by match to protein family HMM PF01741; match to protein family HMM TIGR00220 YP_816376.1 equivalent gene in S.pneumoniae TIGR4 = SP1011; equivalent gene in S.pneumoniae R6 = spr0916; identified by match to protein family HMM PF04138 YP_816377.1 equivalent gene in S.pneumoniae TIGR4 = SP1012; equivalent gene in S.pneumoniae R6 = spr0917; identified by match to protein family HMM PF06177 YP_816378.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde YP_816379.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis YP_816380.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE YP_816381.1 4-OT; member of subfamily 5; forms a dimer; the function in the Escherichia coli cell is unknown YP_816382.1 catalyzes the formation of thymidine 5'-phosphate from thymidine YP_816383.1 equivalent gene in S.pneumoniae TIGR4 = SP1019; equivalent gene in S.pneumoniae R6 = spr0923; identified by match to protein family HMM PF00583 YP_816384.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 YP_816385.1 equivalent gene in S.pneumoniae TIGR4 = SP1021; equivalent gene in S.pneumoniae R6 = spr0925; identified by match to protein family HMM PF05175; match to protein family HMM TIGR00536 YP_816386.1 equivalent gene in S.pneumoniae TIGR4 = SP1022; equivalent gene in S.pneumoniae R6 = spr0926; identified by match to protein family HMM PF01300; match to protein family HMM TIGR00057 YP_816387.1 equivalent gene in S.pneumoniae TIGR4 = SP1023; equivalent gene in S.pneumoniae R6 = spr0927; identified by match to protein family HMM PF00583 YP_816388.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate YP_816389.1 equivalent gene in S.pneumoniae TIGR4 = SP1025; equivalent gene in S.pneumoniae R6 = spr0929 YP_816390.1 equivalent gene in S.pneumoniae TIGR4 = SP1026; equivalent gene in S.pneumoniae R6 = spr0930 YP_816391.1 equivalent gene in S.pneumoniae TIGR4 = SP1027; equivalent gene in S.pneumoniae R6 = spr0931; identified by match to protein family HMM PF06207 YP_816392.1 equivalent gene in S.pneumoniae TIGR4 = SP1029; equivalent gene in S.pneumoniae R6 = spr0932; identified by match to protein family HMM PF01938; match to protein family HMM PF05958; match to protein family HMM TIGR00479 YP_816393.1 equivalent gene in S.pneumoniae TIGR4 = SP1032; equivalent gene in S.pneumoniae R6 = spr0934; identified by match to protein family HMM PF01497 YP_816394.1 equivalent gene in S.pneumoniae TIGR4 = SP1033; equivalent gene in S.pneumoniae R6 = spr0935; identified by match to protein family HMM PF01032 YP_816395.1 equivalent gene in S.pneumoniae TIGR4 = SP1034; equivalent gene in S.pneumoniae R6 = spr0936; identified by match to protein family HMM PF01032 YP_816396.1 equivalent gene in S.pneumoniae TIGR4 = SP1035; equivalent gene in S.pneumoniae R6 = spr0938; identified by match to protein family HMM PF00005 YP_816397.1 equivalent gene in S.pneumoniae TIGR4 = SP1038; equivalent gene in S.pneumoniae R6 = spr0940 YP_816398.1 equivalent gene in S.pneumoniae TIGR4 = SP1039; equivalent gene in S.pneumoniae R6 = spr0941 YP_816399.1 equivalent gene in S.pneumoniae TIGR4 = SP1040; equivalent gene in S.pneumoniae R6 = spr0942; identified by match to protein family HMM PF00239; match to protein family HMM PF07508 YP_816400.1 equivalent gene in S.pneumoniae TIGR4 = SP1041; equivalent gene in S.pneumoniae R6 = spr0943 YP_816401.1 equivalent gene in S.pneumoniae TIGR4 = SP1042; equivalent gene in S.pneumoniae R6 = spr0944 YP_816402.1 equivalent gene in S.pneumoniae TIGR4 = SP1043; equivalent gene in S.pneumoniae R6 = spr0945 YP_816403.1 equivalent gene in S.pneumoniae TIGR4 = SP1044; equivalent gene in S.pneumoniae R6 = spr0946; identified by match to protein family HMM PF03747 YP_816404.1 equivalent gene in S.pneumoniae TIGR4 = SP1045; equivalent gene in S.pneumoniae R6 = spr0947; identified by match to protein family HMM PF00781; match to protein family HMM TIGR00147 YP_816405.1 equivalent gene in S.pneumoniae R6 = spr0948; identified by match to protein family HMM PF00128; match to protein family HMM PF02903 YP_816406.1 equivalent gene in S.pneumoniae TIGR4 = SP1047; equivalent gene in S.pneumoniae R6 = spr0949 YP_816407.1 equivalent gene in S.pneumoniae TIGR4 = SP1048; equivalent gene in S.pneumoniae R6 = spr0950 YP_816408.1 equivalent gene in S.pneumoniae TIGR4 = SP1050; equivalent gene in S.pneumoniae R6 = spr0951; identified by match to protein family HMM PF01381 YP_816409.1 equivalent gene in S.pneumoniae TIGR4 = SP1051; equivalent gene in S.pneumoniae R6 = spr0952; identified by match to protein family HMM PF06414 YP_816410.1 equivalent gene in S.pneumoniae TIGR4 = SP1052; equivalent gene in S.pneumoniae R6 = spr0953 YP_816411.1 equivalent gene in S.pneumoniae TIGR4 = SP1053; equivalent gene in S.pneumoniae R6 = spr0954 YP_816412.1 equivalent gene in S.pneumoniae R6 = spr0955 YP_816413.1 equivalent gene in S.pneumoniae R6 = spr0956; identified by match to protein family HMM PF05713 YP_816414.1 equivalent gene in S.pneumoniae R6 = spr0957; identified by match to protein family HMM PF03432 YP_816415.1 equivalent gene in S.pneumoniae R6 = spr0959 YP_816416.1 equivalent gene in S.pneumoniae R6 = spr0960; identified by match to protein family HMM TIGR01716 YP_816417.1 equivalent gene in S.pneumoniae R6 = spr0961; identified by match to protein family HMM PF00984; match to protein family HMM PF03720; match to protein family HMM PF03721 YP_816418.1 equivalent gene in S.pneumoniae R6 = spr0962 YP_816419.1 equivalent gene in S.pneumoniae R6 = spr0963; identified by match to protein family HMM PF01261 YP_816420.1 equivalent gene in S.pneumoniae R6 = spr0964 YP_816421.1 equivalent gene in S.pneumoniae R6 = spr0965 YP_816422.1 equivalent gene in S.pneumoniae R6 = spr0966; identified by match to protein family HMM PF00501 YP_816423.1 This gene has a tRNA synthetase class II core domain (G, H, P, S and T) protein equivalent gene in S.pneumoniae R6 spr0967; identified by match to protein family HMM PF00587 YP_816424.1 equivalent gene in S.pneumoniae R6 = spr0968 YP_816425.1 equivalent gene in S.pneumoniae R6 = spr0969; identified by match to protein family HMM PF02655 YP_816426.1 equivalent gene in S.pneumoniae R6 = spr0970; identified by match to protein family HMM PF00132 YP_816427.1 equivalent gene in S.pneumoniae R6 = spr0971; identified by match to protein family HMM PF07690 YP_816428.1 equivalent gene in S.pneumoniae R6 = spr0972; identified by match to protein family HMM PF01381 YP_816429.1 equivalent gene in S.pneumoniae TIGR4 = SP1067; equivalent gene in S.pneumoniae R6 = spr0973; identified by match to protein family HMM PF01098 YP_816430.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate YP_816431.1 equivalent gene in S.pneumoniae TIGR4 = SP1069; equivalent gene in S.pneumoniae R6 = spr0975; identified by match to protein family HMM PF04392 YP_816432.1 equivalent gene in S.pneumoniae TIGR4 = SP1070; equivalent gene in S.pneumoniae R6 = spr0976; identified by match to protein family HMM PF02653 YP_816433.1 equivalent gene in S.pneumoniae TIGR4 = SP1071; equivalent gene in S.pneumoniae R6 = spr0977; identified by match to protein family HMM PF00005 YP_816434.1 synthesizes RNA primers at the replication forks YP_816435.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; primary sigma factor of bacterium YP_816436.1 equivalent gene in S.pneumoniae TIGR4 = SP1074; equivalent gene in S.pneumoniae R6 = spr0980; identified by match to protein family HMM PF01883 YP_816437.1 equivalent gene in S.pneumoniae TIGR4 = SP1075; equivalent gene in S.pneumoniae R6 = spr0981; identified by match to protein family HMM PF00534 YP_816438.1 equivalent gene in S.pneumoniae TIGR4 = SP1076; equivalent gene in S.pneumoniae R6 = spr0982; identified by match to protein family HMM PF00534 YP_816439.1 equivalent gene in S.pneumoniae TIGR4 = SP1077; equivalent gene in S.pneumoniae R6 = spr0983; identified by match to protein family HMM PF04024 YP_816440.1 equivalent gene in S.pneumoniae TIGR4 = SP1078 YP_816441.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication YP_816442.1 equivalent gene in S.pneumoniae TIGR4 = SP1080; equivalent gene in S.pneumoniae R6 = spr0985 YP_816443.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_816444.1 equivalent gene in S.pneumoniae TIGR4 = SP1082; equivalent gene in S.pneumoniae R6 = spr0990; identified by match to protein family HMM PF00583 YP_816445.1 equivalent gene in S.pneumoniae TIGR4 = SP1083; equivalent gene in S.pneumoniae R6 = spr0991; identified by match to protein family HMM PF00571; match to protein family HMM PF03061; match to protein family HMM PF07085 YP_816446.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides YP_816447.1 equivalent gene in S.pneumoniae TIGR4 = SP1310; equivalent gene in S.pneumoniae R6 = spr0993 YP_816449.1 equivalent gene in S.pneumoniae TIGR4 = SP1087; equivalent gene in S.pneumoniae R6 = spr0995; identified by match to protein family HMM PF00580; match to protein family HMM TIGR01073 YP_816450.1 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase YP_816451.1 equivalent gene in S.pneumoniae TIGR4 = SP1089; equivalent gene in S.pneumoniae R6 = spr0997; identified by match to protein family HMM PF00117; match to protein family HMM PF07722 YP_816452.1 modulates transcription in response to the NADH/NAD(+) redox state YP_816453.1 equivalent gene in S.pneumoniae TIGR4 = SP1092; equivalent gene in S.pneumoniae R6 = spr0999 YP_816454.1 equivalent gene in S.pneumoniae TIGR4 = SP1093; equivalent gene in S.pneumoniae R6 = spr1000 YP_816455.1 equivalent gene in S.pneumoniae TIGR4 = SP1094; equivalent gene in S.pneumoniae R6 = spr1001; identified by match to protein family HMM PF00266 YP_816456.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP YP_816457.1 equivalent gene in S.pneumoniae TIGR4 = SP1096; equivalent gene in S.pneumoniae R6 = spr1003; identified by match to protein family HMM PF01928 YP_816458.1 equivalent gene in S.pneumoniae TIGR4 = SP1097; equivalent gene in S.pneumoniae R6 = spr1004 This protein has been crystalized; identified by match to protein family HMM PF04607 YP_816459.1 catalyzes the phosphorylation of NAD to NADP YP_816460.1 equivalent gene in S.pneumoniae TIGR4 = SP1099; equivalent gene in S.pneumoniae R6 = spr1006; identified by match to protein family HMM PF00849; match to protein family HMM TIGR00005 YP_816461.1 in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta YP_816462.1 equivalent gene in S.pneumoniae TIGR4 = SP1102; equivalent gene in S.pneumoniae R6 = spr1010; identified by match to protein family HMM PF02575; match to protein family HMM TIGR00103 YP_816463.1 equivalent gene in S.pneumoniae TIGR4 = SP1104; equivalent gene in S.pneumoniae R6 = spr1011; identified by match to protein family HMM PF06912 YP_816464.1 equivalent gene in S.pneumoniae TIGR4 = SP1105; equivalent gene in S.pneumoniae R6 = spr1012; identified by match to protein family HMM PF00829; match to protein family HMM TIGR00061 YP_816465.1 equivalent gene in S.pneumoniae TIGR4 = SP1106; equivalent gene in S.pneumoniae R6 = spr1013; identified by match to protein family HMM PF04327 YP_816466.1 involved in the peptidyltransferase reaction during translation YP_816467.1 equivalent gene in S.pneumoniae TIGR4 = SP1108; equivalent gene in S.pneumoniae R6 = spr1015 YP_816468.1 equivalent gene in S.pneumoniae TIGR4 = SP1109 YP_816469.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities YP_816470.1 equivalent gene in S.pneumoniae TIGR4 = SP1111; equivalent gene in S.pneumoniae R6 = spr1018; identified by match to protein family HMM PF02588 YP_816471.1 equivalent gene in S.pneumoniae TIGR4 = SP1112; equivalent gene in S.pneumoniae R6 = spr1019; identified by match to protein family HMM PF02645; match to protein family HMM TIGR00762 YP_816472.1 equivalent gene in S.pneumoniae TIGR4 = SP1113; equivalent gene in S.pneumoniae R6 = spr1020; identified by match to protein family HMM PF00216 YP_816473.1 equivalent gene in S.pneumoniae TIGR4 = SP1114; equivalent gene in S.pneumoniae R6 = spr1021; identified by match to protein family HMM PF00005 YP_816474.1 equivalent gene in S.pneumoniae TIGR4 = SP1115; equivalent gene in S.pneumoniae R6 = spr1022; identified by match to protein family HMM TIGR01716 YP_816475.1 equivalent gene in S.pneumoniae TIGR4 = SP1116; equivalent gene in S.pneumoniae R6 = spr1023; identified by match to protein family HMM PF07690 YP_816476.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB YP_816477.1 equivalent gene in S.pneumoniae TIGR4 = SP1118; equivalent gene in S.pneumoniae R6 = spr1025; identified by match to protein family HMM PF00128; match to protein family HMM PF02922; match to protein family HMM TIGR02104 YP_816478.1 equivalent gene in S.pneumoniae R6 = spr1027 YP_816479.1 equivalent gene in S.pneumoniae TIGR4 = SP1119; equivalent gene in S.pneumoniae R6 = spr1028; identified by match to protein family HMM PF00171 YP_816480.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain YP_816481.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate YP_816482.1 equivalent gene in S.pneumoniae TIGR4 = SP1123; equivalent gene in S.pneumoniae R6 = spr1031; identified by match to protein family HMM PF00483; match to protein family HMM TIGR02092 YP_816483.1 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose YP_816484.1 equivalent gene in S.pneumoniae TIGR4 = SP1126; equivalent gene in S.pneumoniae R6 = spr1034; identified by match to protein family HMM PF02595; match to protein family HMM TIGR00045 YP_816485.1 equivalent gene in S.pneumoniae TIGR4 = SP1127; equivalent gene in S.pneumoniae R6 = spr1035; identified by match to protein family HMM PF07997 YP_816486.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis YP_816487.1 equivalent gene in S.pneumoniae TIGR4 = SP1147; identified by match to protein family HMM PF00589 YP_816488.1 equivalent gene in S.pneumoniae TIGR4 = SP0299; equivalent gene in S.pneumoniae R6 = spr1038 In TIGR4 this gene is annotated as a truncation; however in R6 there are numerous near perfect copies as well as copies with a slightly longer version with a different end that is not present in either R6 or TIGR4 This indicates it may still function as a transposase; identified by match to protein family HMM PF01710 YP_816489.1 RexAB system found in Gram positive bacteria appears to fulfill the biological roles of RecBCD found in Gram negative bacteria. equivalent gene in S.pneumoniae TIGR4 = SP1151; equivalent gene in S.pneumoniae R6 = spr1039; identified by match to protein family HMM TIGR02774 YP_816490.1 RexAB system found in Gram positive bacteria appears to fulfill the biological roles of RecBCD found in Gram negative bacteria. equivalent gene in S.pneumoniae TIGR4 = SP1152; equivalent gene in S.pneumoniae R6 = spr1040; identified by match to protein family HMM PF00580; match to protein family HMM TIGR02785 YP_816491.1 equivalent gene in S.pneumoniae TIGR4 = SP1153; equivalent gene in S.pneumoniae R6 = spr1041 YP_816492.1 equivalent gene in S.pneumoniae R6 = spr1042; identified by match to protein family HMM PF00746; match to protein family HMM PF04650; match to protein family HMM PF05342; match to protein family HMM PF07501; match to protein family HMM PF07580; match to protein family HMM PF07581; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168 YP_816493.1 essential GTPase; functions in ribosome assembly; binds a unique part of the 23S rRNA; interacts with ribosomal protein L25(Ctc) YP_816494.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids YP_816495.1 equivalent gene in S.pneumoniae TIGR4 = SP1157; equivalent gene in S.pneumoniae R6 = spr1045; identified by match to protein family HMM PF00654; match to protein family HMM PF02080 YP_816496.1 equivalent gene in S.pneumoniae TIGR4 = SP1158 YP_816497.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerS YP_816498.1 equivalent gene in S.pneumoniae TIGR4 = SP1160; equivalent gene in S.pneumoniae R6 = spr1047; identified by match to protein family HMM PF03099; match to protein family HMM TIGR00545 YP_816499.1 equivalent gene in S.pneumoniae TIGR4 = SP1161; equivalent gene in S.pneumoniae R6 = spr1048; identified by match to protein family HMM PF00070; match to protein family HMM PF00364; match to protein family HMM PF01134; match to protein family HMM PF02852; match to protein family HMM PF03486; match to protein family HMM PF07992; match to protein family HMM TIGR01350 YP_816500.1 unlike PdhC proteins from other organisms, some Mycoplasma lack an N-terminal lipoyl domain; in Mycoplasma hyopneumonia the PdhD proteins contains the lipoyl domain YP_816501.1 equivalent gene in S.pneumoniae TIGR4 = SP1163; equivalent gene in S.pneumoniae R6 = spr1050; identified by match to protein family HMM PF02779; match to protein family HMM PF02780 YP_816502.1 equivalent gene in S.pneumoniae TIGR4 = SP1164; equivalent gene in S.pneumoniae R6 = spr1051; identified by match to protein family HMM PF00676 YP_816503.1 equivalent gene in S.pneumoniae TIGR4 = SP1166; equivalent gene in S.pneumoniae R6 = spr1052; identified by match to protein family HMM PF01554; match to protein family HMM TIGR00797 YP_816504.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis YP_816505.1 equivalent gene in S.pneumoniae TIGR4 = SP1168; equivalent gene in S.pneumoniae R6 = spr1054; identified by match to protein family HMM PF00293 YP_816506.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine YP_816507.1 equivalent gene in S.pneumoniae TIGR4 = SP1170; equivalent gene in S.pneumoniae R6 = spr1056 YP_816508.1 equivalent gene in S.pneumoniae TIGR4 = SP1171; equivalent gene in S.pneumoniae R6 = spr1057; identified by match to protein family HMM PF00702; match to protein family HMM TIGR01549; match to protein family HMM TIGR02254 YP_816509.1 equivalent gene in S.pneumoniae TIGR4 = SP1173; equivalent gene in S.pneumoniae R6 = spr1058 YP_816510.1 equivalent gene in S.pneumoniae R6 = spr1059 YP_816511.1 equivalent gene in S.pneumoniae R6 = spr1060; identified by match to protein family HMM PF04270; match to protein family HMM TIGR01363 YP_816512.1 equivalent gene in S.pneumoniae TIGR4 = SP1175; equivalent gene in S.pneumoniae R6 = spr1061; identified by match to protein family HMM PF04270; match to protein family HMM TIGR01363 YP_816513.1 equivalent gene in S.pneumoniae TIGR4 = SP1176; equivalent gene in S.pneumoniae R6 = spr1062; identified by match to protein family HMM PF00391; match to protein family HMM PF02896; match to protein family HMM PF05524; match to protein family HMM TIGR01417 YP_816514.1 equivalent gene in S.pneumoniae TIGR4 = SP1177; equivalent gene in S.pneumoniae R6 = spr1063; identified by match to protein family HMM PF00381; match to protein family HMM TIGR01003 YP_816515.1 equivalent gene in S.pneumoniae TIGR4 = SP1178; equivalent gene in S.pneumoniae R6 = spr1064; identified by match to protein family HMM PF00462; match to protein family HMM TIGR02194 YP_816516.1 Catalyzes the rate-limiting step in dNTP synthesis YP_816517.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE YP_816518.1 equivalent gene in S.pneumoniae TIGR4 = SP1182; equivalent gene in S.pneumoniae R6 = spr1067; identified by match to protein family HMM PF00455; match to protein family HMM PF08220 YP_816520.1 catalyzes the formation of 6-phospho-galactose from a 6-phospho-beta-galactoside YP_816521.1 equivalent gene in S.pneumoniae TIGR4 = SP1185; equivalent gene in S.pneumoniae R6 = spr1070; identified by match to protein family HMM PF02302; match to protein family HMM PF02378; match to protein family HMM TIGR00394; match to protein family HMM TIGR00410; match to protein family HMM TIGR00853 YP_816522.1 equivalent gene in S.pneumoniae TIGR4 = SP1186; equivalent gene in S.pneumoniae R6 = spr1071; identified by match to protein family HMM PF02255; match to protein family HMM TIGR00823 YP_816523.1 equivalent gene in S.pneumoniae TIGR4 = SP1187; equivalent gene in S.pneumoniae R6 = spr1072; identified by match to protein family HMM PF00874; match to protein family HMM PF03123 YP_816524.1 catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in Streptococcus pyogenes there are two paralogs of tagatose-bisphosphate aldolase, encoded by lacD1 and lacD2; expression of lacD1 is highly regulated by environmental conditions while lacD2 specializes in an efficient utilization of carbohydrate sources YP_816525.1 catalyzes the formation of tagatose 1,6-bisphosphate from tagatose 6-phosphate and ATP YP_816526.1 catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate YP_816527.1 catalyzes the interconversion of galactose 6-phosphate to tagatose 6-phosphate; tagatose pathway for galactose utilization YP_816528.1 equivalent gene in S.pneumoniae TIGR4 = SP1194; equivalent gene in S.pneumoniae R6 = spr1077 YP_816529.1 equivalent gene in S.pneumoniae TIGR4 = SP1197; equivalent gene in S.pneumoniae R6 = spr1080 YP_816531.1 binds to the ribosome on the universally-conserved alpha-sarcin loop YP_816532.1 equivalent gene in S.pneumoniae TIGR4 = SP1201; equivalent gene in S.pneumoniae R6 = spr1083; identified by match to protein family HMM PF00149 YP_816533.1 equivalent gene in S.pneumoniae TIGR4 = SP1202; equivalent gene in S.pneumoniae R6 = spr1084; identified by match to protein family HMM PF02463; match to protein family HMM TIGR00634 YP_816534.1 equivalent gene in S.pneumoniae TIGR4 = SP1203; equivalent gene in S.pneumoniae R6 = spr1085; identified by match to protein family HMM PF01316; match to protein family HMM PF02863 YP_816535.1 equivalent gene in S.pneumoniae TIGR4 = SP1204; equivalent gene in S.pneumoniae R6 = spr1086; identified by match to protein family HMM PF01479; match to protein family HMM PF01728; match to protein family HMM TIGR00478 YP_816536.1 equivalent gene in S.pneumoniae TIGR4 = SP1205; equivalent gene in S.pneumoniae R6 = spr1087; identified by match to protein family HMM PF00348 YP_816537.1 catalyzes the bidirectional exonucleolytic cleavage of DNA YP_816538.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides YP_816539.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor YP_816540.1 equivalent gene in S.pneumoniae TIGR4 = SP1210; equivalent gene in S.pneumoniae R6 = spr1091 YP_816541.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs YP_816542.1 equivalent gene in S.pneumoniae R6 = spr1093 YP_816543.1 equivalent gene in S.pneumoniae TIGR4 = SP1213; equivalent gene in S.pneumoniae R6 = spr1094 YP_816544.1 equivalent gene in S.pneumoniae R6 = spr1095; identified by match to protein family HMM PF01053; match to protein family HMM PF01212; match to protein family HMM TIGR01326 YP_816545.1 similar to a domain of the O-acetylhomoserine sulfhydrylase characterized in Leptospira meyeri. equivalent gene in S.pneumoniae R6 = spr1096 YP_816546.1 equivalent gene in S.pneumoniae TIGR4 = SP1215; equivalent gene in S.pneumoniae R6 = spr1097; identified by match to protein family HMM PF01226 YP_816547.1 equivalent gene in S.pneumoniae TIGR4 = SP1218; equivalent gene in S.pneumoniae R6 = spr1098; identified by match to protein family HMM PF04203; match to protein family HMM TIGR01076 YP_816548.1 negatively supercoils closed circular double-stranded DNA YP_816549.1 Converts (S)-lactate and NAD(+) to pyruvate and NADH YP_816550.1 equivalent gene in S.pneumoniae TIGR4 = SP1221; equivalent gene in S.pneumoniae R6 = spr1101; identified by match to protein family HMM PF04851 YP_816551.1 equivalent gene in S.pneumoniae TIGR4 = SP1222; equivalent gene in S.pneumoniae R6 = spr1102; identified by match to protein family HMM PF07669 YP_816552.1 equivalent gene in S.pneumoniae TIGR4 = SP1223; equivalent gene in S.pneumoniae R6 = spr1103; identified by match to protein family HMM PF05016; match to protein family HMM TIGR02385 YP_816553.1 equivalent gene in S.pneumoniae TIGR4 = SP1224; equivalent gene in S.pneumoniae R6 = spr1104 YP_816554.1 equivalent gene in S.pneumoniae TIGR4 = SP1225; equivalent gene in S.pneumoniae R6 = spr1105; identified by match to protein family HMM PF00753 YP_816555.1 equivalent gene in S.pneumoniae TIGR4 = SP1226; equivalent gene in S.pneumoniae R6 = spr1106; identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF00989; match to protein family HMM PF02518; match to protein family HMM TIGR00229 YP_816556.1 equivalent gene in S.pneumoniae TIGR4 = SP1227; equivalent gene in S.pneumoniae R6 = spr1107; identified by match to protein family HMM PF00072; match to protein family HMM PF00486 YP_816557.1 equivalent gene in S.pneumoniae TIGR4 = SP1228; equivalent gene in S.pneumoniae R6 = spr1108; identified by match to protein family HMM PF00633; match to protein family HMM PF00730; match to protein family HMM TIGR01084 YP_816558.1 catalyzes the formation of 10-formyltetrahydrofolate from formate and tetrahydrofolate YP_816559.1 equivalent gene in S.pneumoniae TIGR4 = SP1230; equivalent gene in S.pneumoniae R6 = spr1110; identified by match to protein family HMM PF04127; match to protein family HMM TIGR02114 YP_816560.1 decarboxylates 4-phosphopantothenoylcysteine to form 4'-phosphopantotheine. YP_816561.1 equivalent gene in S.pneumoniae TIGR4 = SP1232; equivalent gene in S.pneumoniae R6 = spr1112 YP_816562.1 equivalent gene in S.pneumoniae TIGR4 = SP1233; equivalent gene in S.pneumoniae R6 = spr1113 YP_816563.1 equivalent gene in S.pneumoniae R6 = spr1114; identified by match to protein family HMM PF02829 YP_816564.1 equivalent gene in S.pneumoniae TIGR4 = SP1235; equivalent gene in S.pneumoniae R6 = spr1115; identified by match to protein family HMM PF00293 YP_816565.1 equivalent gene in S.pneumoniae TIGR4 = SP1236; equivalent gene in S.pneumoniae R6 = spr1116; identified by match to protein family HMM PF00583 YP_816566.1 equivalent gene in S.pneumoniae TIGR4 = SP1237; equivalent gene in S.pneumoniae R6 = spr1117 YP_816567.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion YP_816568.1 equivalent gene in S.pneumoniae TIGR4 = SP1240; equivalent gene in S.pneumoniae R6 = spr1119; identified by match to protein family HMM PF02517 YP_816569.1 equivalent gene in S.pneumoniae TIGR4 = SP1241; equivalent gene in S.pneumoniae R6 = spr1120; identified by match to protein family HMM PF00497; match to protein family HMM PF00528; match to protein family HMM TIGR01726 YP_816570.1 equivalent gene in S.pneumoniae TIGR4 = SP1242; equivalent gene in S.pneumoniae R6 = spr1121; identified by match to protein family HMM PF00005 YP_816571.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate YP_816572.1 equivalent gene in S.pneumoniae TIGR4 = SP1244; equivalent gene in S.pneumoniae R6 = spr1123; identified by match to protein family HMM PF00448; match to protein family HMM PF02881; match to protein family HMM TIGR00064 YP_816573.1 equivalent gene in S.pneumoniae TIGR4 = SP1245; equivalent gene in S.pneumoniae R6 = spr1124; identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484 YP_816574.1 equivalent gene in S.pneumoniae TIGR4 = SP1246; equivalent gene in S.pneumoniae R6 = spr1125; identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484 YP_816575.1 equivalent gene in S.pneumoniae TIGR4 = SP1247; equivalent gene in S.pneumoniae R6 = spr1126; identified by match to protein family HMM PF02463; match to protein family HMM PF06470; match to protein family HMM TIGR00650; match to protein family HMM TIGR02168 YP_816576.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity YP_816577.1 equivalent gene in S.pneumoniae TIGR4 = SP1249; equivalent gene in S.pneumoniae R6 = spr1128; identified by match to protein family HMM PF00478; match to protein family HMM TIGR01306 YP_816578.1 equivalent gene in S.pneumoniae TIGR4 = SP1250; equivalent gene in S.pneumoniae R6 = spr1129 YP_816579.1 equivalent gene in S.pneumoniae TIGR4 = SP1251; equivalent gene in S.pneumoniae R6 = spr1130 YP_816580.1 equivalent gene in S.pneumoniae TIGR4 = SP1252; equivalent gene in S.pneumoniae R6 = spr1131 YP_816581.1 equivalent gene in S.pneumoniae TIGR4 = SP1253; equivalent gene in S.pneumoniae R6 = spr1132 YP_816582.1 equivalent gene in S.pneumoniae TIGR4 = SP1254 YP_816583.1 equivalent gene in S.pneumoniae TIGR4 = SP1255; equivalent gene in S.pneumoniae R6 = spr1133 YP_816585.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis YP_816586.1 equivalent gene in S.pneumoniae TIGR4 = SP1259; equivalent gene in S.pneumoniae R6 = spr1138; identified by match to protein family HMM PF04237 YP_816587.1 equivalent gene in S.pneumoniae TIGR4 = SP1260; equivalent gene in S.pneumoniae R6 = spr1139; identified by match to protein family HMM PF03932 YP_816588.1 equivalent gene in S.pneumoniae TIGR4 = SP1261; equivalent gene in S.pneumoniae R6 = spr1140; identified by match to protein family HMM PF04304 YP_816589.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity YP_816590.1 equivalent gene in S.pneumoniae TIGR4 = SP1264; equivalent gene in S.pneumoniae R6 = spr1142; identified by match to protein family HMM PF04087 YP_816591.1 equivalent gene in S.pneumoniae TIGR4 = SP1266; equivalent gene in S.pneumoniae R6 = spr1144; identified by match to protein family HMM PF02481; match to protein family HMM TIGR00732 YP_816592.1 equivalent gene in S.pneumoniae TIGR4 = SP1267; equivalent gene in S.pneumoniae R6 = spr1145; identified by match to protein family HMM PF00483 YP_816593.1 equivalent gene in S.pneumoniae TIGR4 = SP1268; equivalent gene in S.pneumoniae R6 = spr1146; identified by match to protein family HMM PF00892 YP_816594.1 equivalent gene in S.pneumoniae TIGR4 = SP1269; equivalent gene in S.pneumoniae R6 = spr1147; identified by match to protein family HMM PF01633; match to protein family HMM PF01636 YP_816595.1 equivalent gene in S.pneumoniae TIGR4 = SP1270; equivalent gene in S.pneumoniae R6 = spr1148 YP_816596.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers YP_816597.1 equivalent gene in S.pneumoniae TIGR4 = SP1272; equivalent gene in S.pneumoniae R6 = spr1150; identified by match to protein family HMM PF01943 YP_816598.1 equivalent gene in S.pneumoniae TIGR4 = SP1273; equivalent gene in S.pneumoniae R6 = spr1151; identified by match to protein family HMM PF04991 YP_816599.1 equivalent gene in S.pneumoniae TIGR4 = SP1274; equivalent gene in S.pneumoniae R6 = spr1152; identified by match to protein family HMM PF04991 YP_816600.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity YP_816601.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers YP_816602.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis YP_816603.1 regulates pyrimidine biosynthesis by binding to the mRNA of the pyr genes, also has been shown to have uracil phosphoribosyltransferase activity YP_816604.1 equivalent gene in S.pneumoniae TIGR4 = SP1279; equivalent gene in S.pneumoniae R6 = spr1157; identified by match to protein family HMM PF00633; match to protein family HMM PF00730; match to protein family HMM TIGR01083 YP_816605.1 equivalent gene in S.pneumoniae TIGR4 = SP1280; equivalent gene in S.pneumoniae R6 = spr1158; identified by match to protein family HMM PF02620; COG1399 YP_816606.1 equivalent gene in S.pneumoniae TIGR4 = SP1282; equivalent gene in S.pneumoniae R6 = spr1161; identified by match to protein family HMM PF00005 YP_816607.1 metalloprotease YP_816608.1 equivalent gene in S.pneumoniae TIGR4 = SP1284; equivalent gene in S.pneumoniae R6 = spr1163; identified by match to protein family HMM PF04011 YP_816609.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA YP_816610.1 equivalent gene in S.pneumoniae TIGR4 = SP1286; equivalent gene in S.pneumoniae R6 = spr1165; identified by match to protein family HMM PF00860; match to protein family HMM TIGR00801 YP_816611.1 equivalent gene in S.pneumoniae TIGR4 = SP1287; equivalent gene in S.pneumoniae R6 = spr1166; identified by match to protein family HMM PF00448; match to protein family HMM PF02881; match to protein family HMM PF02978; match to protein family HMM TIGR00959 YP_816612.1 equivalent gene in S.pneumoniae TIGR4 = SP1288; equivalent gene in S.pneumoniae R6 = spr1167; identified by match to protein family HMM PF04297; match to protein family HMM PF04967 YP_816613.1 equivalent gene in S.pneumoniae TIGR4 = SP1289; equivalent gene in S.pneumoniae R6 = spr1168 YP_816614.1 equivalent gene in S.pneumoniae TIGR4 = SP1290; equivalent gene in S.pneumoniae R6 = spr1169; identified by match to protein family HMM PF01966 YP_816615.1 equivalent gene in S.pneumoniae TIGR4 = SP1291; equivalent gene in S.pneumoniae R6 = spr1170; identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484 YP_816616.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site YP_816617.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling YP_816618.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling YP_816619.1 equivalent gene in S.pneumoniae TIGR4 = SP1296; equivalent gene in S.pneumoniae R6 = spr1174; identified by match to protein family HMM PF01817; match to protein family HMM TIGR01805 YP_816620.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group YP_816621.1 equivalent gene in S.pneumoniae TIGR4 = SP1298; equivalent gene in S.pneumoniae R6 = spr1176; identified by match to protein family HMM PF01368; match to protein family HMM PF02272 YP_816622.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome YP_816623.1 equivalent gene in S.pneumoniae TIGR4 = SP1300; equivalent gene in S.pneumoniae R6 = spr1178 YP_816624.1 equivalent gene in S.pneumoniae R6 = spr1179; identified by match to protein family HMM PF04261; match to protein family HMM TIGR01413 YP_816625.1 equivalent gene in S.pneumoniae TIGR4 = SP0733; equivalent gene in S.pneumoniae R6 = spr1180 YP_816626.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer YP_816627.1 equivalent gene in S.pneumoniae TIGR4 = SP1307; equivalent gene in S.pneumoniae R6 = spr1182 YP_816628.1 equivalent gene in S.pneumoniae TIGR4 = SP1308; equivalent gene in S.pneumoniae R6 = spr1183; identified by match to protein family HMM PF00005 YP_816629.1 equivalent gene in S.pneumoniae R6 = spr1184 YP_816630.1 This gene is a fragement of the glucokinase genes 3' end. equivalent gene in S.pneumoniae R6 = spr1185 YP_816631.1 equivalent gene in S.pneumoniae TIGR4 = SP1676; equivalent gene in S.pneumoniae R6 = spr1186; identified by match to protein family HMM PF00701 YP_816632.1 equivalent gene in S.pneumoniae R6 = spr1188; identified by match to protein family HMM PF00383; match to protein family HMM TIGR01354 YP_816633.1 equivalent gene in S.pneumoniae R6 = spr1189 YP_816634.1 equivalent gene in S.pneumoniae R6 = spr1190 YP_816635.1 equivalent gene in S.pneumoniae R6 = spr1191; identified by match to protein family HMM PF00005; match to protein family HMM TIGR01727 YP_816636.1 equivalent gene in S.pneumoniae R6 = spr1192; identified by match to protein family HMM PF00528 YP_816637.1 equivalent gene in S.pneumoniae R6 = spr1193; identified by match to protein family HMM PF00528 YP_816638.1 equivalent gene in S.pneumoniae R6 = spr1194; identified by match to protein family HMM PF00496 YP_816639.1 equivalent gene in S.pneumoniae R6 = spr1195; identified by match to protein family HMM PF07646 YP_816640.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate YP_816641.1 equivalent gene in S.pneumoniae R6 = spr1199 YP_816642.1 equivalent gene in S.pneumoniae TIGR4 = SP1340; equivalent gene in S.pneumoniae R6 = spr1201 YP_816643.1 equivalent gene in S.pneumoniae TIGR4 = SP1341; equivalent gene in S.pneumoniae R6 = spr1202; identified by match to protein family HMM PF00005 YP_816644.1 equivalent gene in S.pneumoniae TIGR4 = SP1342; equivalent gene in S.pneumoniae R6 = spr1203; identified by match to protein family HMM PF00005; match to protein family HMM PF00664 YP_816645.1 equivalent gene in S.pneumoniae TIGR4 = SP1343; equivalent gene in S.pneumoniae R6 = spr1204; identified by match to protein family HMM PF00326 YP_816646.1 equivalent gene in S.pneumoniae TIGR4 = SP1344; equivalent gene in S.pneumoniae R6 = spr1205; identified by match to protein family HMM PF05147 YP_816647.1 equivalent gene in S.pneumoniae TIGR4 = SP1346; equivalent gene in S.pneumoniae R6 = spr1206; identified by match to protein family HMM PF02517 YP_816648.1 equivalent gene in S.pneumoniae TIGR4 = SP1333 YP_816649.1 equivalent gene in S.pneumoniae TIGR4 = SP1348; equivalent gene in S.pneumoniae R6 = spr1207 YP_816650.1 equivalent gene in S.pneumoniae TIGR4 = SP1349; equivalent gene in S.pneumoniae R6 = spr1208 YP_816651.1 equivalent gene in S.pneumoniae TIGR4 = SP1350; equivalent gene in S.pneumoniae R6 = spr1209; identified by match to protein family HMM PF06970 YP_816652.1 equivalent gene in S.pneumoniae R6 = spr1210 YP_816654.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors YP_816655.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit YP_816656.1 equivalent gene in S.pneumoniae R6 = spr1213 YP_816657.1 equivalent gene in S.pneumoniae TIGR4 = SP1356; equivalent gene in S.pneumoniae R6 = spr1214; identified by match to protein family HMM PF01979; match to protein family HMM PF07969 YP_816658.1 equivalent gene in S.pneumoniae TIGR4 = SP1357; equivalent gene in S.pneumoniae R6 = spr1215; identified by match to protein family HMM PF00005; match to protein family HMM PF00664 YP_816659.1 equivalent gene in S.pneumoniae TIGR4 = SP1358; equivalent gene in S.pneumoniae R6 = spr1216; identified by match to protein family HMM PF00005; match to protein family HMM PF00664 YP_816660.1 equivalent gene in S.pneumoniae TIGR4 = SP1359; equivalent gene in S.pneumoniae R6 = spr1217; identified by match to protein family HMM PF01625; match to protein family HMM PF01641; match to protein family HMM TIGR00357; match to protein family HMM TIGR00401 YP_816661.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate YP_816662.1 catalyzes the formation of L-aspartate 4-semialdehyde from L-homoserine YP_816663.1 enables recognition and targeting of proteins for proteolysis, involved in negative regulation of competence YP_816664.1 equivalent gene in S.pneumoniae TIGR4 = SP1363; equivalent gene in S.pneumoniae R6 = spr1221 YP_816665.1 equivalent gene in S.pneumoniae TIGR4 = SP1364; equivalent gene in S.pneumoniae R6 = spr1222 YP_816666.1 equivalent gene in S.pneumoniae TIGR4 = SP1365; equivalent gene in S.pneumoniae R6 = spr1223; identified by match to protein family HMM PF00535 YP_816667.1 equivalent gene in S.pneumoniae TIGR4 = SP1366; equivalent gene in S.pneumoniae R6 = spr1224; identified by match to protein family HMM PF00534 YP_816668.1 equivalent gene in S.pneumoniae TIGR4 = SP1367; equivalent gene in S.pneumoniae R6 = spr1225; identified by match to protein family HMM PF04991 YP_816669.1 equivalent gene in S.pneumoniae TIGR4 = SP1368; equivalent gene in S.pneumoniae R6 = spr1226; identified by match to protein family HMM PF03816; match to protein family HMM TIGR00350 YP_816670.1 catalyzes the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis YP_816671.1 equivalent gene in S.pneumoniae TIGR4 = SP1370; equivalent gene in S.pneumoniae R6 = spr1228; identified by match to protein family HMM PF01202 YP_816672.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis YP_816673.1 equivalent gene in S.pneumoniae TIGR4 = SP1372; equivalent gene in S.pneumoniae R6 = spr1230; identified by match to protein family HMM PF06133 YP_816674.1 catalyzes the formation of 4-hydroxyphenylpyruvate from prephenate YP_816675.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis YP_816676.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis YP_816677.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate YP_816678.1 catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis YP_816679.1 equivalent gene in S.pneumoniae TIGR4 = SP1378; equivalent gene in S.pneumoniae R6 = spr1236 YP_816680.1 equivalent gene in S.pneumoniae TIGR4 = SP1380; equivalent gene in S.pneumoniae R6 = spr1237 YP_816681.1 equivalent gene in S.pneumoniae TIGR4 = SP1381; equivalent gene in S.pneumoniae R6 = spr1238; identified by match to protein family HMM PF00005 YP_816682.1 converts 1,4-alpha-D-glucans to maltodextrin YP_816683.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_816684.1 equivalent gene in S.pneumoniae TIGR4 = SP1384; equivalent gene in S.pneumoniae R6 = spr1241; identified by match to protein family HMM PF04525 YP_816685.1 equivalent gene in S.pneumoniae TIGR4 = SP1386; equivalent gene in S.pneumoniae R6 = spr1243; identified by match to protein family HMM PF01547 YP_816686.1 equivalent gene in S.pneumoniae TIGR4 = SP1387; equivalent gene in S.pneumoniae R6 = spr1244; identified by match to protein family HMM PF00528 YP_816687.1 equivalent gene in S.pneumoniae TIGR4 = SP1388; equivalent gene in S.pneumoniae R6 = spr1245; identified by match to protein family HMM PF00528 YP_816688.1 equivalent gene in S.pneumoniae TIGR4 = SP1389; equivalent gene in S.pneumoniae R6 = spr1246; identified by match to protein family HMM PF00005 YP_816689.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis YP_816690.1 equivalent gene in S.pneumoniae TIGR4 = SP1391; equivalent gene in S.pneumoniae R6 = spr1248 YP_816691.1 equivalent gene in S.pneumoniae TIGR4 = SP1392; equivalent gene in S.pneumoniae R6 = spr1249; identified by match to protein family HMM PF03306; match to protein family HMM TIGR01252 YP_816692.1 equivalent gene in S.pneumoniae TIGR4 = SP1393; equivalent gene in S.pneumoniae R6 = spr1250; identified by match to protein family HMM PF00392 YP_816693.1 equivalent gene in S.pneumoniae TIGR4 = SP1394; equivalent gene in S.pneumoniae R6 = spr1251; identified by match to protein family HMM PF00497 YP_816694.1 equivalent gene in S.pneumoniae TIGR4 = SP1395; equivalent gene in S.pneumoniae R6 = spr1252; identified by match to protein family HMM PF01895; match to protein family HMM TIGR02135 YP_816695.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation YP_816696.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation YP_816697.1 equivalent gene in S.pneumoniae TIGR4 = SP1398; equivalent gene in S.pneumoniae R6 = spr1255; identified by match to protein family HMM PF00528; match to protein family HMM TIGR00974 YP_816698.1 equivalent gene in S.pneumoniae TIGR4 = SP1399; equivalent gene in S.pneumoniae R6 = spr1256; identified by match to protein family HMM PF00528; match to protein family HMM TIGR02138 YP_816699.1 equivalent gene in S.pneumoniae TIGR4 = SP1400; equivalent gene in S.pneumoniae R6 = spr1257; identified by match to protein family HMM PF01547; match to protein family HMM TIGR02136 YP_816700.1 equivalent gene in S.pneumoniae TIGR4 = SP1402; equivalent gene in S.pneumoniae R6 = spr1259; identified by match to protein family HMM PF01189 YP_816701.1 equivalent gene in S.pneumoniae TIGR4 = SP1403; equivalent gene in S.pneumoniae R6 = spr1260; identified by match to protein family HMM PF00459 YP_816702.1 equivalent gene in S.pneumoniae TIGR4 = SP1404; equivalent gene in S.pneumoniae R6 = spr1261; identified by match to protein family HMM PF05256 YP_816703.1 the anti-alpha factor Spx interacts with RNA polymerase alpha subunit C-terminal domain in a region that interacts with the sigma 70 subunit and may interfere with activation of promoters; in Bacillus subtilis this protein is a substrate for ClpXP protease; blocks transcription of the competence regulatory gene encoded by the srf operon; regulates a number of genes involved in thiol homeostasis including trxA and trxB; monomeric member of ArsC family of proteins; does not bind DNA; contains a disulfide bond between C10 and C13 which may sense disulfide stress YP_816704.1 equivalent gene in S.pneumoniae TIGR4 = SP1406; equivalent gene in S.pneumoniae R6 = spr1263; identified by match to protein family HMM PF07314; match to protein family HMM TIGR01906 YP_816705.1 equivalent gene in S.pneumoniae TIGR4 = SP1407; equivalent gene in S.pneumoniae R6 = spr1264; identified by match to protein family HMM PF00702; match to protein family HMM TIGR01457; match to protein family HMM TIGR01460 YP_816706.1 equivalent gene in S.pneumoniae TIGR4 = SP1408; equivalent gene in S.pneumoniae R6 = spr1265; identified by match to protein family HMM PF01643 YP_816707.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_816708.1 equivalent gene in S.pneumoniae TIGR4 = SP1410; equivalent gene in S.pneumoniae R6 = spr1267 YP_816709.1 equivalent gene in S.pneumoniae TIGR4 = SP1411; equivalent gene in S.pneumoniae R6 = spr1268; identified by match to protein family HMM PF06103 YP_816710.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein YP_816711.1 catalyzes the phosphorylation of the phosphocarrier protein HPr of the bacterial phosphotransferase system YP_816712.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA YP_816713.1 equivalent gene in S.pneumoniae TIGR4 = SP1415; equivalent gene in S.pneumoniae R6 = spr1272; identified by match to protein family HMM PF01182 YP_816714.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step YP_816715.1 equivalent gene in S.pneumoniae R6 = spr1274 The R6 gene is annotated as a choline binding protein truncation (spsA-truncation); identified by match to protein family HMM PF01473 YP_816716.1 equivalent gene in S.pneumoniae TIGR4 = SP1419; equivalent gene in S.pneumoniae R6 = spr1275; identified by match to protein family HMM PF00583 YP_816717.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers YP_816718.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-diphosphate and nicotinate from nicotinate D-ribonucleotide and diphosphate YP_816719.1 equivalent gene in S.pneumoniae TIGR4 = SP1422; equivalent gene in S.pneumoniae R6 = spr1278 YP_816720.1 equivalent gene in S.pneumoniae TIGR4 = SP1423; equivalent gene in S.pneumoniae R6 = spr1279; identified by match to protein family HMM PF01381 YP_816721.1 equivalent gene in S.pneumoniae TIGR4 = SP1424; equivalent gene in S.pneumoniae R6 = spr1280 YP_816722.1 equivalent gene in S.pneumoniae TIGR4 = SP1426; equivalent gene in S.pneumoniae R6 = spr1281; identified by match to protein family HMM PF00005 YP_816723.1 equivalent gene in S.pneumoniae TIGR4 = SP1427; equivalent gene in S.pneumoniae R6 = spr1282; identified by match to protein family HMM PF01136 YP_816724.1 equivalent gene in S.pneumoniae R6 = spr1283 YP_816725.1 equivalent gene in S.pneumoniae TIGR4 = SP1429; equivalent gene in S.pneumoniae R6 = spr1284; identified by match to protein family HMM PF01136 YP_816726.1 Possibly an isoschizomer of XbaI. equivalent gene in S.pneumoniae TIGR4 = SP1431; equivalent gene in S.pneumoniae R6 spr1287; identified by match to protein family HMM PF01555 YP_816727.1 equivalent gene in S.pneumoniae TIGR4 = SP1432 YP_816728.1 equivalent gene in S.pneumoniae TIGR4 = SP1433; equivalent gene in S.pneumoniae R6 = spr1288; identified by match to protein family HMM PF00165 YP_816729.1 equivalent gene in S.pneumoniae TIGR4 = SP1434; equivalent gene in S.pneumoniae R6 = spr1289; identified by match to protein family HMM PF00005 YP_816730.1 equivalent gene in S.pneumoniae TIGR4 = SP1435; equivalent gene in S.pneumoniae R6 = spr1290; identified by match to protein family HMM PF00005 YP_816731.1 equivalent gene in S.pneumoniae TIGR4 = SP1436; equivalent gene in S.pneumoniae R6 = spr1291; identified by match to protein family HMM TIGR02185 YP_816732.1 equivalent gene in S.pneumoniae TIGR4 = SP1437; equivalent gene in S.pneumoniae R6 = spr1292; identified by match to protein family HMM PF02361 YP_816733.1 equivalent gene in S.pneumoniae TIGR4 = SP1438; equivalent gene in S.pneumoniae R6 = spr1293; identified by match to protein family HMM PF00005 YP_816734.1 equivalent gene in S.pneumoniae R6 = spr1294 YP_816735.1 equivalent gene in S.pneumoniae R6 = spr1295 YP_816736.1 equivalent gene in S.pneumoniae R6 = spr1296 YP_816737.1 equivalent gene in S.pneumoniae R6 = spr1297 YP_816738.1 equivalent gene in S.pneumoniae TIGR4 = SP1442; equivalent gene in S.pneumoniae R6 = spr1298; identified by match to protein family HMM PF05717 YP_816739.1 equivalent gene in S.pneumoniae TIGR4 = SP1443; equivalent gene in S.pneumoniae R6 = spr1299 YP_816740.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway YP_816741.1 equivalent gene in S.pneumoniae TIGR4 = SP1446; equivalent gene in S.pneumoniae R6 = spr1301; identified by match to protein family HMM PF00392; match to protein family HMM PF07702 YP_816742.1 equivalent gene in S.pneumoniae TIGR4 = SP1447; equivalent gene in S.pneumoniae R6 = spr1302; identified by match to protein family HMM PF00892 YP_816743.1 equivalent gene in S.pneumoniae TIGR4 = SP1448; equivalent gene in S.pneumoniae R6 = spr1303; identified by match to protein family HMM PF00144 YP_816744.1 equivalent gene in S.pneumoniae TIGR4 = SP1449; equivalent gene in S.pneumoniae R6 = spr1304 YP_816745.1 equivalent gene in S.pneumoniae TIGR4 = SP1450; equivalent gene in S.pneumoniae R6 = spr1305; identified by match to protein family HMM PF00657 YP_816746.1 equivalent gene in S.pneumoniae TIGR4 = SP1451; equivalent gene in S.pneumoniae R6 = spr1306; identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484 YP_816747.1 equivalent gene in S.pneumoniae TIGR4 = SP1452; equivalent gene in S.pneumoniae R6 = spr1307 YP_816748.1 equivalent gene in S.pneumoniae TIGR4 = SP1453; equivalent gene in S.pneumoniae R6 = spr1308 YP_816749.1 equivalent gene in S.pneumoniae TIGR4 = SP1454 YP_816750.1 equivalent gene in S.pneumoniae R6 = spr1309; identified by similarity to GB:AAL001131 YP_816751.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_816752.1 equivalent gene in S.pneumoniae TIGR4 = SP1457; equivalent gene in S.pneumoniae R6 = spr1311; identified by match to protein family HMM PF00588; match to protein family HMM PF08032; match to protein family HMM TIGR00186 YP_816753.1 equivalent gene in S.pneumoniae TIGR4 = SP1458; equivalent gene in S.pneumoniae R6 = spr1312; identified by match to protein family HMM PF00070; match to protein family HMM PF01134; match to protein family HMM PF01266; match to protein family HMM PF03486; match to protein family HMM PF07992; match to protein family HMM TIGR01292 YP_816754.1 equivalent gene in S.pneumoniae TIGR4 = SP1459; equivalent gene in S.pneumoniae R6 = spr1313 YP_816755.1 equivalent gene in S.pneumoniae TIGR4 = SP1460; equivalent gene in S.pneumoniae R6 = spr1314; identified by match to protein family HMM PF00005 YP_816756.1 equivalent gene in S.pneumoniae TIGR4 = SP1461; equivalent gene in S.pneumoniae R6 = spr1315; identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726 YP_816757.1 equivalent gene in S.pneumoniae TIGR4 = SP1462; equivalent gene in S.pneumoniae R6 = spr1316; identified by match to protein family HMM PF03960; match to protein family HMM TIGR01617 YP_816758.1 equivalent gene in S.pneumoniae TIGR4 = SP1463; equivalent gene in S.pneumoniae R6 = spr1317; identified by match to protein family HMM PF01035; match to protein family HMM TIGR00589 YP_816759.1 equivalent gene in S.pneumoniae TIGR4 = SP1464; equivalent gene in S.pneumoniae R6 = spr1318; identified by match to protein family HMM PF00583 YP_816760.1 equivalent gene in S.pneumoniae TIGR4 = SP1465; equivalent gene in S.pneumoniae R6 = spr1319 YP_816761.1 equivalent gene in S.pneumoniae TIGR4 = SP1466; equivalent gene in S.pneumoniae R6 = spr1320; identified by match to protein family HMM PF03006; match to protein family HMM TIGR01065 YP_816762.1 with PdxST is involved in the biosynthesis of pyridoxal 5'-phosphate; PdxT catalyzes the hydrolysis of glutamine to glutamate and ammonia; PdxS utilizes the ammonia to synthesize pyridoxal 5'-phosphate YP_816763.1 with PdxT forms pyridoxal 5'-phosphate from glutamine, either ribose 5-phosphate or ribulose 5-phosphate, and either glyceraldehyde 3-phosphate or dihydroxyacetone phosphate YP_816764.1 equivalent gene in S.pneumoniae TIGR4 = SP1469; equivalent gene in S.pneumoniae R6 = spr1323; identified by match to protein family HMM PF00070; match to protein family HMM PF02852; match to protein family HMM PF07992 YP_816766.1 equivalent gene in S.pneumoniae TIGR4 = SP1470; equivalent gene in S.pneumoniae R6 = spr1324; identified by match to protein family HMM PF02424 YP_816767.1 equivalent gene in S.pneumoniae TIGR4 = SP1471; equivalent gene in S.pneumoniae R6 = spr1325; identified by match to protein family HMM PF03358 YP_816768.1 equivalent gene in S.pneumoniae TIGR4 = SP1472; equivalent gene in S.pneumoniae R6 = spr1326; identified by match to protein family HMM PF03358 YP_816769.1 equivalent gene in S.pneumoniae TIGR4 = SP1473; equivalent gene in S.pneumoniae R6 = spr1327; identified by match to protein family HMM PF05979 YP_816770.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_816771.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_816772.1 equivalent gene in S.pneumoniae TIGR4 = SP1476; equivalent gene in S.pneumoniae R6 = spr1330 YP_816773.1 equivalent gene in S.pneumoniae TIGR4 = SP1477; equivalent gene in S.pneumoniae R6 = spr1331 YP_816774.1 equivalent gene in S.pneumoniae TIGR4 = SP1478; equivalent gene in S.pneumoniae R6 = spr1332; identified by match to protein family HMM PF00248 YP_816775.1 equivalent gene in S.pneumoniae TIGR4 = SP1479; equivalent gene in S.pneumoniae R6 = spr1333; identified by match to protein family HMM PF01522 YP_816776.1 equivalent gene in S.pneumoniae TIGR4 = SP1480; equivalent gene in S.pneumoniae R6 = spr1334 YP_816777.1 equivalent gene in S.pneumoniae TIGR4 = SP1482; equivalent gene in S.pneumoniae R6 = spr1335; identified by match to protein family HMM PF01118; match to protein family HMM PF01408 YP_816778.1 equivalent gene in S.pneumoniae TIGR4 = SP1483; equivalent gene in S.pneumoniae R6 = spr1336; identified by match to protein family HMM PF00270; match to protein family HMM PF00271 YP_816779.1 equivalent gene in S.pneumoniae TIGR4 = SP1487; equivalent gene in S.pneumoniae R6 = spr1342 YP_816780.1 equivalent gene in S.pneumoniae TIGR4 = SP1488 YP_816781.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_816783.1 equivalent gene in S.pneumoniae TIGR4 = SP1491; equivalent gene in S.pneumoniae R6 = spr1344; identified by match to protein family HMM PF00230 YP_816784.1 equivalent gene in S.pneumoniae TIGR4 = SP1492; equivalent gene in S.pneumoniae R6 = spr1345; identified by match to protein family HMM PF00746; match to protein family HMM PF06458; match to protein family HMM TIGR01167 YP_816785.1 equivalent gene in S.pneumoniae TIGR4 = SP1493; equivalent gene in S.pneumoniae R6 = spr1346 YP_816786.1 equivalent gene in S.pneumoniae TIGR4 = SP1494; equivalent gene in S.pneumoniae R6 = spr1347 YP_816787.1 equivalent gene in S.pneumoniae TIGR4 = SP1496; equivalent gene in S.pneumoniae R6 = spr1349 YP_816788.1 equivalent gene in S.pneumoniae TIGR4 = SP1498; equivalent gene in S.pneumoniae R6 = spr1351; identified by match to protein family HMM PF00408; match to protein family HMM PF02878; match to protein family HMM PF02879; match to protein family HMM PF02880 YP_816789.1 equivalent gene in S.pneumoniae TIGR4 = SP1499; equivalent gene in S.pneumoniae R6 = spr1352; identified by match to protein family HMM TIGR01295 YP_816790.1 equivalent gene in S.pneumoniae TIGR4 = SP1500; equivalent gene in S.pneumoniae R6 = spr1353; identified by match to protein family HMM PF00497 YP_816791.1 equivalent gene in S.pneumoniae TIGR4 = SP1501; equivalent gene in S.pneumoniae R6 = spr1354; identified by match to protein family HMM PF00005 YP_816792.1 equivalent gene in S.pneumoniae TIGR4 = SP1502; equivalent gene in S.pneumoniae R6 = spr1355; identified by match to protein family HMM PF00528; match to protein family HMM TIGR01726 YP_816793.1 equivalent gene in S.pneumoniae TIGR4 = SP1504; equivalent gene in S.pneumoniae R6 = spr1356; identified by match to protein family HMM PF00515; match to protein family HMM PF07719 YP_816794.1 equivalent gene in S.pneumoniae TIGR4 = SP1505; equivalent gene in S.pneumoniae R6 = spr1357; identified by match to protein family HMM PF01594 YP_816795.1 equivalent gene in S.pneumoniae TIGR4 = SP1506; equivalent gene in S.pneumoniae R6 = spr1358 YP_816796.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane YP_816797.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit YP_816798.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit YP_816799.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit YP_816800.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex YP_816801.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel. YP_816802.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 YP_816803.1 produces ATP from ADP in the presence of a proton gradient across the membrane; subunit C is part of the membrane proton channel F0 YP_816804.1 equivalent gene in S.pneumoniae TIGR4 = SP0915; equivalent gene in S.pneumoniae R6 = spr1367; identified by match to protein family HMM PF00665 YP_816805.1 equivalent gene in S.pneumoniae TIGR4 = SP1516; equivalent gene in S.pneumoniae R6 = spr1368; identified by match to protein family HMM PF00583 YP_816807.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_816808.1 YceG family protein; equivalent gene in S.pneumoniae TIGR4 = SP1518; equivalent gene in S.pneumoniae R6 = spr1370; identified by match to protein family HMM PF02618; match to protein family HMM TIGR00247; COG1559 YP_816809.1 equivalent gene in S.pneumoniae TIGR4 = SP1519; equivalent gene in S.pneumoniae R6 = spr1371; identified by match to protein family HMM PF00583 YP_816810.1 equivalent gene in S.pneumoniae TIGR4 = SP1520; equivalent gene in S.pneumoniae R6 = spr1372; identified by match to protein family HMM PF00583 YP_816811.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis YP_816812.1 equivalent gene in S.pneumoniae TIGR4 = SP1522; equivalent gene in S.pneumoniae R6 = spr1374 YP_816813.1 equivalent gene in S.pneumoniae TIGR4 = SP1523; equivalent gene in S.pneumoniae R6 = spr1375; identified by match to protein family HMM PF00176; match to protein family HMM PF00271; match to protein family HMM PF04434 YP_816814.1 equivalent gene in S.pneumoniae TIGR4 = SP1524; equivalent gene in S.pneumoniae R6 = spr1376; identified by match to protein family HMM PF00155 YP_816815.1 catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine YP_816816.1 This may be a degenerate gene resulting from mutation in the ATP-binding protein located just upstream. equivalent gene in S.pneumoniae R6 = spr1378 YP_816817.1 This may be a degenerate gene resulting from mutations in an ATP-binding protein liberating the downstream gene. equivalent gene in S.pneumoniae R6 = spr1379 YP_816818.1 equivalent gene in S.pneumoniae TIGR4 = SP1527; equivalent gene in S.pneumoniae R6 = spr1382; identified by match to protein family HMM PF00496 YP_816819.1 equivalent gene in S.pneumoniae TIGR4 = SP1529; equivalent gene in S.pneumoniae R6 = spr1383; identified by match to protein family HMM PF01943 YP_816820.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of lysine to UDP-N-acetylmuramoyl-L-alanyl-D-glutamate forming UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysine YP_816821.1 equivalent gene in S.pneumoniae TIGR4 = SP1531; equivalent gene in S.pneumoniae R6 = spr1385; identified by match to protein family HMM PF05532 YP_816822.1 equivalent gene in S.pneumoniae TIGR4 = SP1533; equivalent gene in S.pneumoniae R6 = spr1388 YP_816823.1 catalyzes the hydrolysis of pyrophosphate to phosphate YP_816824.1 equivalent gene in S.pneumoniae TIGR4 = SP1535; equivalent gene in S.pneumoniae R6 = spr1390; identified by match to protein family HMM PF01541 YP_816825.1 equivalent gene in S.pneumoniae TIGR4 = SP1536; equivalent gene in S.pneumoniae R6 = spr1391; identified by match to protein family HMM PF05175 YP_816826.1 equivalent gene in S.pneumoniae TIGR4 = SP1537; equivalent gene in S.pneumoniae R6 = spr1392; identified by match to protein family HMM PF00575 YP_816827.1 equivalent gene in S.pneumoniae TIGR4 = SP1538; equivalent gene in S.pneumoniae R6 = spr1393; identified by match to protein family HMM PF00160; match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484 YP_816828.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit YP_816829.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA YP_816830.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 YP_816831.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_816832.1 equivalent gene in S.pneumoniae R6 = spr1398; identified by match to protein family HMM PF00903 YP_816833.1 catalyzes the formation of oxalozcetate and L-glutamate from L-aspartate and 2-oxoglutarate YP_816834.1 equivalent gene in S.pneumoniae TIGR4 = SP1545; equivalent gene in S.pneumoniae R6 = spr1400; identified by match to protein family HMM PF03413 YP_816835.1 equivalent gene in S.pneumoniae TIGR4 = SP1546; equivalent gene in S.pneumoniae R6 = spr1402; identified by match to protein family HMM PF02525; match to protein family HMM PF03358 YP_816836.1 equivalent gene in S.pneumoniae R6 = spr1403; identified by match to protein family HMM PF01391; match to protein family HMM PF04650; match to protein family HMM PF07501; match to protein family HMM PF07554; match to protein family HMM TIGR01167; match to protein family HMM TIGR01168 YP_816837.1 equivalent gene in S.pneumoniae R6 = spr1404; identified by match to protein family HMM PF05043 YP_816838.1 equivalent gene in S.pneumoniae TIGR4 = SP1547; equivalent gene in S.pneumoniae R6 = spr1405; identified by match to protein family HMM PF03883 YP_816839.1 equivalent gene in S.pneumoniae R6 = spr1406 YP_816840.1 equivalent gene in S.pneumoniae TIGR4 = SP1548; equivalent gene in S.pneumoniae R6 = spr1407 YP_816841.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_816842.1 YghU; B2989; one of eight glutathione transferase proteins from E. coli YP_816843.1 equivalent gene in S.pneumoniae TIGR4 = SP1551; equivalent gene in S.pneumoniae R6 = spr1410; identified by match to protein family HMM PF00122; match to protein family HMM PF00689; match to protein family HMM PF00690; match to protein family HMM PF00702; match to protein family HMM TIGR01494 YP_816844.1 equivalent gene in S.pneumoniae TIGR4 = SP1552; equivalent gene in S.pneumoniae R6 = spr1411; identified by match to protein family HMM PF01545; match to protein family HMM TIGR01297 YP_816845.1 equivalent gene in S.pneumoniae TIGR4 = SP1553; equivalent gene in S.pneumoniae R6 = spr1412; identified by match to protein family HMM PF00005 YP_816846.1 catalyzes the addition and repair of the 3'-terminal CCA sequence in tRNA; these proteins belong to the CCA-adding enzyme subfamily 2 which does not have phosphohydrolase activity YP_816847.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis YP_816848.1 equivalent gene in S.pneumoniae TIGR4 = SP1557; equivalent gene in S.pneumoniae R6 = spr1415; identified by match to protein family HMM PF02645; match to protein family HMM TIGR00762 YP_816849.1 equivalent gene in S.pneumoniae TIGR4 = SP1558; equivalent gene in S.pneumoniae R6 = spr1416; identified by match to protein family HMM PF06619 YP_816850.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate YP_816851.1 equivalent gene in S.pneumoniae TIGR4 = SP1560; equivalent gene in S.pneumoniae R6 = spr1418; identified by match to protein family HMM PF07949 YP_816852.1 equivalent gene in S.pneumoniae TIGR4 = SP1561; equivalent gene in S.pneumoniae R6 = spr1419; identified by match to protein family HMM PF02457; match to protein family HMM TIGR00159 YP_816853.1 equivalent gene in S.pneumoniae TIGR4 = SP1563; equivalent gene in S.pneumoniae R6 = spr1421; identified by match to protein family HMM PF00070; match to protein family HMM PF03486; match to protein family HMM PF07992 YP_816854.1 equivalent gene in S.pneumoniae TIGR4 = SP1564; equivalent gene in S.pneumoniae R6 = spr1422; identified by match to protein family HMM PF02650; match to protein family HMM TIGR00647; COG1481 YP_816855.1 equivalent gene in S.pneumoniae TIGR4 = SP1565; equivalent gene in S.pneumoniae R6 = spr1423; identified by match to protein family HMM PF01933; match to protein family HMM TIGR01826 YP_816856.1 equivalent gene in S.pneumoniae TIGR4 = SP1566; equivalent gene in S.pneumoniae R6 = spr1424; identified by match to protein family HMM PF03668 YP_816857.1 equivalent gene in S.pneumoniae TIGR4 = SP1567; equivalent gene in S.pneumoniae R6 = spr1425; identified by match to protein family HMM PF01042; match to protein family HMM TIGR00004 YP_816858.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential YP_816859.1 binds and unfolds substrates as part of the ClpXP protease YP_816860.1 equivalent gene in S.pneumoniae TIGR4 = SP1570; equivalent gene in S.pneumoniae R6 = spr1428 YP_816861.1 equivalent gene in S.pneumoniae TIGR4 = SP1571; equivalent gene in S.pneumoniae R6 = spr1429; identified by match to protein family HMM PF00186 YP_816862.1 equivalent gene in S.pneumoniae TIGR4 = SP1572; equivalent gene in S.pneumoniae R6 = spr1430; identified by match to protein family HMM PF00210 YP_816863.1 equivalent gene in S.pneumoniae TIGR4 = SP1573; equivalent gene in S.pneumoniae R6 = spr1431; identified by match to protein family HMM PF01183; match to protein family HMM PF01473 YP_816864.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate YP_816865.1 equivalent gene in S.pneumoniae TIGR4 = SP1575; equivalent gene in S.pneumoniae R6 = spr1433; identified by match to protein family HMM PF04271; match to protein family HMM TIGR01446 YP_816866.1 catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis YP_816867.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis YP_816868.1 equivalent gene in S.pneumoniae TIGR4 = SP1578; equivalent gene in S.pneumoniae R6 = spr1436 YP_816869.1 equivalent gene in S.pneumoniae TIGR4 = SP1580; equivalent gene in S.pneumoniae R6 = spr1437; identified by match to protein family HMM PF00005; match to protein family HMM PF03459 YP_816870.1 equivalent gene in S.pneumoniae TIGR4 = SP1583; equivalent gene in S.pneumoniae R6 = spr1438; identified by match to protein family HMM PF00857 YP_816871.1 CodY; DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase (By similarity). It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor YP_816872.1 equivalent gene in S.pneumoniae TIGR4 = SP1586; equivalent gene in S.pneumoniae R6 = spr1440; identified by match to protein family HMM PF00270; match to protein family HMM PF00271 YP_816873.1 equivalent gene in S.pneumoniae TIGR4 = SP1587; equivalent gene in S.pneumoniae R6 = spr1441; identified by match to protein family HMM PF07690 YP_816874.1 Involved in disulfide oxidoreductase activity and electron transport YP_816875.1 equivalent gene in S.pneumoniae TIGR4 = SP1589; equivalent gene in S.pneumoniae R6 = spr1443 YP_816876.1 equivalent gene in S.pneumoniae TIGR4 = SP1590; equivalent gene in S.pneumoniae R6 = spr1444; identified by match to protein family HMM PF07685 YP_816877.1 equivalent gene in S.pneumoniae TIGR4 = SP1591; equivalent gene in S.pneumoniae R6 = spr1445; identified by match to protein family HMM PF00557 YP_816878.1 equivalent gene in S.pneumoniae TIGR4 = SP1592 YP_816879.1 equivalent gene in S.pneumoniae TIGR4 = SP1597; equivalent gene in S.pneumoniae R6 = spr1449 YP_816880.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine YP_816881.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability YP_816882.1 equivalent gene in S.pneumoniae TIGR4 = SP1600; equivalent gene in S.pneumoniae R6 = spr1453; identified by match to protein family HMM PF07690 YP_816883.1 equivalent gene in S.pneumoniae TIGR4 = SP1601; equivalent gene in S.pneumoniae R6 = spr1454 YP_816884.1 equivalent gene in S.pneumoniae TIGR4 = SP1602; equivalent gene in S.pneumoniae R6 = spr1455; identified by match to protein family HMM PF03831; match to protein family HMM TIGR00686 YP_816885.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP YP_816886.1 equivalent gene in S.pneumoniae TIGR4 = SP1604; equivalent gene in S.pneumoniae R6 = spr1457 YP_816887.1 equivalent gene in S.pneumoniae TIGR4 = SP1605; equivalent gene in S.pneumoniae R6 = spr1458 YP_816888.1 equivalent gene in S.pneumoniae TIGR4 = SP1606; equivalent gene in S.pneumoniae R6 = spr1459; identified by match to protein family HMM PF00535 YP_816889.1 equivalent gene in S.pneumoniae TIGR4 = SP1607; equivalent gene in S.pneumoniae R6 = spr1460; identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF04321; match to protein family HMM PF07993; match to protein family HMM TIGR01179 YP_816890.1 equivalent gene in S.pneumoniae TIGR4 = SP1608; equivalent gene in S.pneumoniae R6 = spr1461; identified by match to protein family HMM PF01266 YP_816891.1 equivalent gene in S.pneumoniae TIGR4 = SP1609; equivalent gene in S.pneumoniae R6 = spr1462; identified by match to protein family HMM PF01784; match to protein family HMM TIGR00486 YP_816892.1 equivalent gene in S.pneumoniae TIGR4 = SP1610; equivalent gene in S.pneumoniae R6 = spr1463; identified by match to protein family HMM PF04816 YP_816893.1 equivalent gene in S.pneumoniae TIGR4 = SP1623; equivalent gene in S.pneumoniae R6 = spr1464; identified by match to protein family HMM PF00122; match to protein family HMM PF00702; match to protein family HMM TIGR01494 YP_816894.1 equivalent gene in S.pneumoniae TIGR4 = SP1624; equivalent gene in S.pneumoniae R6 = spr1465; identified by match to protein family HMM PF01553 YP_816895.1 equivalent gene in S.pneumoniae TIGR4 = SP1625; equivalent gene in S.pneumoniae R6 = spr1466; identified by match to protein family HMM PF03596; match to protein family HMM TIGR00779 YP_816896.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence YP_816897.1 equivalent gene in S.pneumoniae TIGR4 = SP1627; equivalent gene in S.pneumoniae R6 = spr1468 YP_816899.1 equivalent gene in S.pneumoniae TIGR4 = SP1630; equivalent gene in S.pneumoniae R6 = spr1470 YP_816900.1 equivalent gene in S.pneumoniae TIGR4 = SP1630; equivalent gene in S.pneumoniae R6 = spr1471 YP_816901.1 catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr) YP_816902.1 equivalent gene in S.pneumoniae TIGR4 = SP1632; equivalent gene in S.pneumoniae R6 = spr1473; identified by match to protein family HMM PF02518 YP_816903.1 equivalent gene in S.pneumoniae TIGR4 = SP1633; equivalent gene in S.pneumoniae R6 = spr1474; identified by match to protein family HMM PF00072; match to protein family HMM PF00486 YP_816904.1 equivalent gene in S.pneumoniae TIGR4 = SP1634; equivalent gene in S.pneumoniae R6 = spr1475 YP_816905.1 equivalent gene in S.pneumoniae TIGR4 = SP1636; equivalent gene in S.pneumoniae R6 = spr1477; identified by match to protein family HMM PF02082 YP_816906.1 equivalent gene in S.pneumoniae TIGR4 = SP1637; equivalent gene in S.pneumoniae R6 = spr1479; identified by match to protein family HMM PF00149 YP_816907.1 equivalent gene in S.pneumoniae TIGR4 = SP1638; equivalent gene in S.pneumoniae R6 = spr1480; identified by match to protein family HMM PF01047; match to protein family HMM PF01325; match to protein family HMM PF02742; match to protein family HMM PF04023 YP_816908.1 equivalent gene in S.pneumoniae R6 = spr1481 YP_816909.1 equivalent gene in S.pneumoniae R6 = spr1482 YP_816910.1 equivalent gene in S.pneumoniae TIGR4 = SP1641; equivalent gene in S.pneumoniae R6 = spr1483 YP_816911.1 equivalent gene in S.pneumoniae TIGR4 = SP1642 This gene has a frameshift relative to the TIGR4 SP1642 gene. YP_816912.1 equivalent gene in S.pneumoniae TIGR4 = SP1643; equivalent gene in S.pneumoniae R6 = spr1485 YP_816913.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine YP_816914.1 equivalent gene in S.pneumoniae TIGR4 = SP1645; equivalent gene in S.pneumoniae R6 = spr1487; identified by match to protein family HMM PF01842; match to protein family HMM PF01966; match to protein family HMM PF02824; match to protein family HMM PF04607; match to protein family HMM TIGR00691 YP_816915.1 equivalent gene in S.pneumoniae TIGR4 = SP1646; equivalent gene in S.pneumoniae R6 = spr1490; identified by match to protein family HMM PF00753 YP_816916.1 equivalent gene in S.pneumoniae TIGR4 = SP1647; equivalent gene in S.pneumoniae R6 = spr1491; identified by match to protein family HMM PF01431; match to protein family HMM PF05649 YP_816917.1 equivalent gene in S.pneumoniae TIGR4 = SP1648; equivalent gene in S.pneumoniae R6 = spr1492; identified by match to protein family HMM PF00005 YP_816918.1 equivalent gene in S.pneumoniae TIGR4 = SP1649; equivalent gene in S.pneumoniae R6 = spr1493; identified by match to protein family HMM PF00950 YP_816919.1 equivalent gene in S.pneumoniae TIGR4 = SP1650; equivalent gene in S.pneumoniae R6 = spr1494; identified by match to protein family HMM PF01297 YP_816920.1 antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein YP_816921.1 equivalent gene in S.pneumoniae TIGR4 = SP1652; equivalent gene in S.pneumoniae R6 = spr1496; identified by match to protein family HMM PF02687 YP_816922.1 equivalent gene in S.pneumoniae TIGR4 = SP1653; equivalent gene in S.pneumoniae R6 = spr1497; identified by match to protein family HMM PF00005 YP_816923.1 equivalent gene in S.pneumoniae TIGR4 = SP1654; equivalent gene in S.pneumoniae R6 = spr1498 YP_816924.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate YP_816925.1 equivalent gene in S.pneumoniae TIGR4 = SP1656; equivalent gene in S.pneumoniae R6 = spr1500 YP_816926.1 equivalent gene in S.pneumoniae TIGR4 = SP1658; equivalent gene in S.pneumoniae R6 = spr1501 YP_816927.1 equivalent gene in S.pneumoniae TIGR4 = SP1658 YP_816928.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme YP_816930.1 equivalent gene in S.pneumoniae TIGR4 = SP1661; equivalent gene in S.pneumoniae R6 = spr1505; identified by match to protein family HMM PF05103 YP_816931.1 equivalent gene in S.pneumoniae TIGR4 = SP1662; equivalent gene in S.pneumoniae R6 = spr1506; identified by match to protein family HMM PF01479 YP_816932.1 equivalent gene in S.pneumoniae TIGR4 = SP1663; equivalent gene in S.pneumoniae R6 = spr1507; identified by match to protein family HMM PF02325 YP_816933.1 equivalent gene in S.pneumoniae TIGR4 = SP1664; equivalent gene in S.pneumoniae R6 = spr1508; identified by match to protein family HMM PF04472 YP_816934.1 equivalent gene in S.pneumoniae TIGR4 = SP1665; equivalent gene in S.pneumoniae R6 = spr1509; identified by match to protein family HMM TIGR00044 YP_816935.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function YP_816936.1 equivalent gene in S.pneumoniae TIGR4 = SP1667; equivalent gene in S.pneumoniae R6 = spr1511; identified by match to protein family HMM PF02491; match to protein family HMM TIGR01174 YP_816937.1 equivalent gene in S.pneumoniae TIGR4 = SP1668; equivalent gene in S.pneumoniae R6 = spr1512; identified by match to protein family HMM TIGR02206 YP_816938.1 equivalent gene in S.pneumoniae TIGR4 = SP1669; equivalent gene in S.pneumoniae R6 = spr1513; identified by match to protein family HMM PF00293 YP_816939.1 equivalent gene in S.pneumoniae TIGR4 = SP1670; equivalent gene in S.pneumoniae R6 = spr1514; identified by match to protein family HMM PF01225; match to protein family HMM PF02875; match to protein family HMM TIGR01143 YP_816940.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli YP_816941.1 involved in a recombinational process of DNA repair, independent of the recBC complex YP_816942.1 equivalent gene in S.pneumoniae TIGR4 = SP1673; equivalent gene in S.pneumoniae R6 = spr1517; identified by match to protein family HMM PF00905; match to protein family HMM PF03717 YP_816943.1 equivalent gene in S.pneumoniae TIGR4 = SP1674; equivalent gene in S.pneumoniae R6 = spr1518; identified by match to protein family HMM PF01380; match to protein family HMM PF01418 YP_816944.1 equivalent gene in S.pneumoniae TIGR4 = SP1675; equivalent gene in S.pneumoniae R6 = spr1519; identified by match to protein family HMM PF00480 YP_816945.1 equivalent gene in S.pneumoniae TIGR4 = SP1676; equivalent gene in S.pneumoniae R6 = spr1520; identified by match to protein family HMM PF00701 YP_816946.1 equivalent gene in S.pneumoniae TIGR4 = SP1677; equivalent gene in S.pneumoniae R6 = spr1522; identified by match to protein family HMM PF04854 YP_816947.1 equivalent gene in S.pneumoniae R6 = spr1523 YP_816948.1 equivalent gene in S.pneumoniae TIGR4 = SP1680; equivalent gene in S.pneumoniae R6 = spr1524; identified by match to protein family HMM PF04074; match to protein family HMM TIGR00022 YP_816949.1 equivalent gene in S.pneumoniae TIGR4 = SP1681; equivalent gene in S.pneumoniae R6 = spr1525; identified by match to protein family HMM PF00528 YP_816950.1 equivalent gene in S.pneumoniae TIGR4 = SP1682; equivalent gene in S.pneumoniae R6 = spr1526; identified by match to protein family HMM PF00528 YP_816951.1 equivalent gene in S.pneumoniae TIGR4 = SP1683; equivalent gene in S.pneumoniae R6 = spr1527; identified by match to protein family HMM PF01547 YP_816952.1 equivalent gene in S.pneumoniae TIGR4 = SP1684; equivalent gene in S.pneumoniae R6 = spr1528; identified by match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826 YP_816953.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate YP_816954.1 equivalent gene in S.pneumoniae TIGR4 = SP1686; equivalent gene in S.pneumoniae R6 = spr1530; identified by match to protein family HMM PF01118; match to protein family HMM PF01408; match to protein family HMM PF02894; match to protein family HMM PF03447 YP_816955.1 neuraminidase B; equivalent gene in S.pneumoniae TIGR4 = SP1687; equivalent gene in S.pneumoniae R6 = spr1531; identified by match to protein family HMM PF02012; match to protein family HMM PF02973 YP_816956.1 equivalent gene in S.pneumoniae TIGR4 = SP1688; equivalent gene in S.pneumoniae R6 = spr1532; identified by match to protein family HMM PF00528 YP_816957.1 equivalent gene in S.pneumoniae TIGR4 = SP1689; equivalent gene in S.pneumoniae R6 = spr1533; identified by match to protein family HMM PF00528 YP_816958.1 equivalent gene in S.pneumoniae TIGR4 = SP1690; equivalent gene in S.pneumoniae R6 = spr1534; identified by match to protein family HMM PF01547 YP_816959.1 equivalent gene in S.pneumoniae TIGR4 = SP1691; equivalent gene in S.pneumoniae R6 = spr1535; identified by match to protein family HMM PF04074; match to protein family HMM TIGR00022 YP_816960.1 equivalent gene in S.pneumoniae R6 = spr1536; identified by match to protein family HMM PF02012; match to protein family HMM PF02973; match to protein family HMM TIGR01167 YP_816961.1 equivalent gene in S.pneumoniae TIGR4 = SP1694; equivalent gene in S.pneumoniae R6 = spr1537 YP_816962.1 equivalent gene in S.pneumoniae TIGR4 = SP1695; equivalent gene in S.pneumoniae R6 = spr1538; identified by match to protein family HMM PF05448 YP_816963.1 catalyzes branch migration in Holliday junction intermediates YP_816964.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer YP_816965.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids YP_816966.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive YP_816967.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive YP_816968.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins YP_816969.1 equivalent gene in S.pneumoniae TIGR4 = SP1704; equivalent gene in S.pneumoniae R6 = spr1546; identified by match to protein family HMM PF00005 YP_816970.1 equivalent gene in S.pneumoniae TIGR4 = SP1705; equivalent gene in S.pneumoniae R6 = spr1547 YP_816971.1 equivalent gene in S.pneumoniae TIGR4 = SP1706; equivalent gene in S.pneumoniae R6 = spr1548 YP_816972.1 equivalent gene in S.pneumoniae R6 = spr1549 YP_816973.1 equivalent gene in S.pneumoniae R6 = spr1550; identified by match to protein family HMM PF01381; match to protein family HMM TIGR01716 YP_816974.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains YP_816975.1 equivalent gene in S.pneumoniae TIGR4 = SP1710; equivalent gene in S.pneumoniae R6 = spr1554; identified by match to protein family HMM PF00881 YP_816976.1 Primosomal protein that may act to load helicase DnaC during DNA replication YP_816977.1 equivalent gene in S.pneumoniae TIGR4 = SP1712; equivalent gene in S.pneumoniae R6 = spr1556; identified by match to protein family HMM PF07261 YP_816978.1 equivalent gene in S.pneumoniae TIGR4 = SP1713; equivalent gene in S.pneumoniae R6 = spr1557; identified by match to protein family HMM PF03477; match to protein family HMM TIGR00244 YP_816979.1 equivalent gene in S.pneumoniae TIGR4 = SP1714; equivalent gene in S.pneumoniae R6 = spr1558; identified by match to protein family HMM PF00392 YP_816980.1 equivalent gene in S.pneumoniae TIGR4 = SP1715; equivalent gene in S.pneumoniae R6 = spr1559; identified by match to protein family HMM PF00005 YP_816981.1 equivalent gene in S.pneumoniae TIGR4 = SP1715; equivalent gene in S.pneumoniae R6 = spr1560 YP_816982.1 equivalent gene in S.pneumoniae TIGR4 = SP1716; equivalent gene in S.pneumoniae R6 = spr1561 YP_816983.1 equivalent gene in S.pneumoniae TIGR4 = SP1717; equivalent gene in S.pneumoniae R6 = spr1562; identified by match to protein family HMM PF00005 YP_816984.1 equivalent gene in S.pneumoniae TIGR4 = SP1720; equivalent gene in S.pneumoniae R6 = spr1564 YP_816985.1 equivalent gene in S.pneumoniae TIGR4 = SP1721; equivalent gene in S.pneumoniae R6 = spr1565; identified by match to protein family HMM PF00480 YP_816986.1 equivalent gene in S.pneumoniae TIGR4 = SP1722; equivalent gene in S.pneumoniae R6 = spr1566; identified by match to protein family HMM PF00358; match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826; match to protein family HMM TIGR00830; match to protein family HMM TIGR01996 YP_816987.1 equivalent gene in S.pneumoniae TIGR4 = SP1723 YP_816988.1 equivalent gene in S.pneumoniae TIGR4 = SP1724; equivalent gene in S.pneumoniae R6 = spr1568; identified by match to protein family HMM PF00251; match to protein family HMM TIGR01322 YP_816989.1 equivalent gene in S.pneumoniae TIGR4 = SP1725; equivalent gene in S.pneumoniae R6 = spr1569; identified by match to protein family HMM PF00356; match to protein family HMM PF00532 YP_816990.1 equivalent gene in S.pneumoniae TIGR4 = SP1726; equivalent gene in S.pneumoniae R6 = spr1570; identified by match to protein family HMM TIGR00532 YP_816991.1 equivalent gene in S.pneumoniae TIGR4 = SP1727; equivalent gene in S.pneumoniae R6 = spr1571; identified by match to protein family HMM PF01154; match to protein family HMM TIGR01835 YP_816992.1 equivalent gene in S.pneumoniae TIGR4 = SP1728; equivalent gene in S.pneumoniae R6 = spr1572 YP_816993.1 equivalent gene in S.pneumoniae TIGR4 = SP1730; equivalent gene in S.pneumoniae R6 = spr1575 YP_816994.1 equivalent gene in S.pneumoniae TIGR4 = SP1731; equivalent gene in S.pneumoniae R6 = spr1576; identified by match to protein family HMM PF06738 YP_816995.1 equivalent gene in S.pneumoniae TIGR4 = SP1732; equivalent gene in S.pneumoniae R6 = spr1577; identified by match to protein family HMM PF00069; match to protein family HMM PF01163; match to protein family HMM PF03793 YP_816996.1 equivalent gene in S.pneumoniae TIGR4 = SP1733; equivalent gene in S.pneumoniae R6 = spr1578; identified by match to protein family HMM PF00481 YP_816997.1 equivalent gene in S.pneumoniae TIGR4 = SP1734; equivalent gene in S.pneumoniae R6 = spr1579; identified by match to protein family HMM PF01029; match to protein family HMM PF01189; match to protein family HMM TIGR00563 YP_816998.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth YP_816999.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity YP_817000.1 Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits YP_817001.1 Essential for recycling GMP and indirectly, cGMP YP_817002.1 equivalent gene in S.pneumoniae TIGR4 = SP1739; equivalent gene in S.pneumoniae R6 = spr1584; identified by match to protein family HMM PF00013; match to protein family HMM PF01966; match to protein family HMM TIGR00277 YP_817003.1 equivalent gene in S.pneumoniae TIGR4 = SP1740; equivalent gene in S.pneumoniae R6 = spr1585; identified by match to protein family HMM PF06769; match to protein family HMM TIGR02116 YP_817004.1 equivalent gene in S.pneumoniae TIGR4 = SP1741; equivalent gene in S.pneumoniae R6 = spr1586; identified by match to protein family HMM PF02604; match to protein family HMM TIGR01552 YP_817005.1 equivalent gene in S.pneumoniae TIGR4 = SP1742; equivalent gene in S.pneumoniae R6 = spr1587; identified by match to protein family HMM PF05636 YP_817006.1 equivalent gene in S.pneumoniae TIGR4 = SP1743; equivalent gene in S.pneumoniae R6 = spr1588 YP_817007.1 equivalent gene in S.pneumoniae TIGR4 = SP1744; equivalent gene in S.pneumoniae R6 = spr1589; identified by match to protein family HMM PF02410; match to protein family HMM TIGR00090 YP_817008.1 equivalent gene in S.pneumoniae TIGR4 = SP1745; equivalent gene in S.pneumoniae R6 = spr1590; identified by match to protein family HMM PF00857 YP_817009.1 equivalent gene in S.pneumoniae TIGR4 = SP1746; equivalent gene in S.pneumoniae R6 = spr1591; identified by match to protein family HMM PF01966; match to protein family HMM TIGR00277; match to protein family HMM TIGR00488 YP_817010.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria YP_817011.1 equivalent gene in S.pneumoniae TIGR4 = SP1748; equivalent gene in S.pneumoniae R6 = spr1593; identified by match to protein family HMM PF01985; match to protein family HMM TIGR00253 YP_817012.1 in Bacillus subtilis this enzyme appears to be involved in 30S ribosomal RNA subunit biogenesis YP_817013.1 equivalent gene in S.pneumoniae TIGR4 = SP1750; equivalent gene in S.pneumoniae R6 = spr1595; identified by match to protein family HMM TIGR01662; match to protein family HMM TIGR01668 YP_817014.1 equivalent gene in S.pneumoniae TIGR4 = SP1751; equivalent gene in S.pneumoniae R6 = spr1596; identified by match to protein family HMM PF01544 YP_817015.1 equivalent gene in S.pneumoniae TIGR4 = SP1752; equivalent gene in S.pneumoniae R6 = spr1597; identified by match to protein family HMM PF00924 YP_817016.1 involved in the import of serine and threonine coupled with the import of sodium YP_817017.1 equivalent gene in S.pneumoniae TIGR4 = SP1754; equivalent gene in S.pneumoniae R6 = spr1599; identified by match to protein family HMM PF06081 YP_817018.1 equivalent gene in S.pneumoniae TIGR4 = SP1774; equivalent gene in S.pneumoniae R6 = spr1600; identified by match to protein family HMM PF01047 YP_817019.1 equivalent gene in S.pneumoniae TIGR4 = SP1775; equivalent gene in S.pneumoniae R6 = spr1601 YP_817020.1 equivalent gene in S.pneumoniae TIGR4 = SP1776; equivalent gene in S.pneumoniae R6 = spr1602; identified by match to protein family HMM PF00085; match to protein family HMM TIGR01068 YP_817021.1 equivalent gene in S.pneumoniae TIGR4 = SP1777; equivalent gene in S.pneumoniae R6 = spr1603; identified by match to protein family HMM PF01227 YP_817022.1 equivalent gene in S.pneumoniae TIGR4 = SP1778; equivalent gene in S.pneumoniae R6 = spr1604; identified by match to protein family HMM PF00230 YP_817023.1 equivalent gene in S.pneumoniae TIGR4 = SP1779; equivalent gene in S.pneumoniae R6 = spr1605 YP_817024.1 equivalent gene in S.pneumoniae TIGR4 = SP1780; equivalent gene in S.pneumoniae R6 = spr1606; identified by match to protein family HMM PF01432; match to protein family HMM TIGR00181 YP_817025.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase YP_817026.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype YP_817027.1 equivalent gene in S.pneumoniae R6 = spr1609; identified by match to protein family HMM PF00293 YP_817028.1 equivalent gene in S.pneumoniae TIGR4 = SP1784; equivalent gene in S.pneumoniae R6 = spr1610; identified by match to protein family HMM PF02163 YP_817029.1 equivalent gene in S.pneumoniae TIGR4 = SP1785; equivalent gene in S.pneumoniae R6 = spr1611 YP_817030.1 equivalent gene in S.pneumoniae TIGR4 = SP1786; equivalent gene in S.pneumoniae R6 = spr1612; identified by match to protein family HMM PF03681 YP_817031.1 equivalent gene in S.pneumoniae R6 = spr1614 YP_817032.1 equivalent gene in S.pneumoniae TIGR4 = SP1789; equivalent gene in S.pneumoniae R6 = spr1615 YP_817033.1 equivalent gene in S.pneumoniae TIGR4 = SP1790; equivalent gene in S.pneumoniae R6 = spr1616; identified by match to protein family HMM PF00004 YP_817034.1 equivalent gene in S.pneumoniae TIGR4 = SP1795; equivalent gene in S.pneumoniae R6 = spr1617; identified by match to protein family HMM PF00251; match to protein family HMM TIGR01322 YP_817035.1 equivalent gene in S.pneumoniae R6 = spr1618; identified by match to protein family HMM PF00528 YP_817036.1 equivalent gene in S.pneumoniae R6 = spr1619; identified by match to protein family HMM PF00528 YP_817037.1 equivalent gene in S.pneumoniae R6 = spr1620; identified by match to protein family HMM PF01547 YP_817038.1 equivalent gene in S.pneumoniae R6 = spr1621; identified by match to protein family HMM PF00356; match to protein family HMM PF00532 YP_817039.1 equivalent gene in S.pneumoniae TIGR4 = SP1800; equivalent gene in S.pneumoniae R6 = spr1622; identified by match to protein family HMM PF05043 YP_817040.1 equivalent gene in S.pneumoniae TIGR4 = SP1802; equivalent gene in S.pneumoniae R6 = spr1623 YP_817041.1 equivalent gene in S.pneumoniae TIGR4 = SP1803; equivalent gene in S.pneumoniae R6 = spr1624 YP_817042.1 equivalent gene in S.pneumoniae TIGR4 = SP1804; equivalent gene in S.pneumoniae R6 = spr1625; identified by match to protein family HMM PF03780 YP_817043.1 equivalent gene in S.pneumoniae TIGR4 = SP1805; equivalent gene in S.pneumoniae R6 = spr1626; identified by match to protein family HMM PF05532 YP_817044.1 equivalent gene in S.pneumoniae TIGR4 = SP1807; equivalent gene in S.pneumoniae R6 = spr1627; identified by match to protein family HMM PF00583 YP_817045.1 equivalent gene in S.pneumoniae TIGR4 = SP1808; equivalent gene in S.pneumoniae R6 = spr1628; identified by match to protein family HMM PF01478; match to protein family HMM PF06750 YP_817046.1 equivalent gene in S.pneumoniae TIGR4 = SP1809; equivalent gene in S.pneumoniae R6 = spr1629; identified by match to protein family HMM PF01381; match to protein family HMM PF06114 YP_817047.1 equivalent gene in S.pneumoniae TIGR4 = SP1810; equivalent gene in S.pneumoniae R6 = spr1630 YP_817048.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis YP_817049.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate YP_817050.1 catalyzes the formation of 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate from N-(5-phospho-beta-D-ribosyl)-anthranilate in tryptophan biosynthesis YP_817051.1 involved in tryptophan biosynthesis; amino acid biosynthesis; converts 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate to C(1)-(3-indolyl)-glycerol 3-phosphate and carbon dioxide and water YP_817052.1 Catalyzes the conversion of N-(5-phospho-D-ribosyl)-anthranilate and diphosphate to anthranilate and 5-phospho-alpha-D-ribose 1-diphosphate YP_817053.1 TrpG; with TrpE catalyzes the formation of anthranilate and glutamate from chorismate and glutamine; TrpG provides the glutamine amidotransferase activity YP_817054.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine YP_817055.1 equivalent gene in S.pneumoniae R6 = spr1638 YP_817057.1 equivalent gene in S.pneumoniae TIGR4 = SP1821; equivalent gene in S.pneumoniae R6 = spr1639; identified by match to protein family HMM PF00356; match to protein family HMM PF00532 YP_817058.1 equivalent gene in S.pneumoniae TIGR4 = SP1823; equivalent gene in S.pneumoniae R6 = spr1641; identified by match to protein family HMM PF02308 YP_817059.1 equivalent gene in S.pneumoniae TIGR4 = SP1824; equivalent gene in S.pneumoniae R6 = spr1643; identified by match to protein family HMM PF00528 YP_817060.1 equivalent gene in S.pneumoniae TIGR4 = SP1825; equivalent gene in S.pneumoniae R6 = spr1644; identified by match to protein family HMM PF00005; match to protein family HMM PF03459 YP_817061.1 equivalent gene in S.pneumoniae TIGR4 = SP1826; equivalent gene in S.pneumoniae R6 = spr1645 YP_817062.1 equivalent gene in S.pneumoniae TIGR4 = SP1827; equivalent gene in S.pneumoniae R6 = spr1646 YP_817064.1 equivalent gene in S.pneumoniae TIGR4 = SP1828; equivalent gene in S.pneumoniae R6 = spr1647; identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF02719; match to protein family HMM PF07993; match to protein family HMM TIGR01179 YP_817065.1 catalyzes the formation of alpha-D-glucose 1-phosphate and UDP-galactose from UDP-glucose and alpha-D-galactose 1-phosphate in galactose metabolism YP_817066.1 equivalent gene in S.pneumoniae TIGR4 = SP1830; equivalent gene in S.pneumoniae R6 = spr1649 YP_817067.1 equivalent gene in S.pneumoniae TIGR4 = SP1831; equivalent gene in S.pneumoniae R6 = spr1650 YP_817068.1 equivalent gene in S.pneumoniae TIGR4 = SP1832; equivalent gene in S.pneumoniae R6 = spr1651 YP_817069.1 equivalent gene in S.pneumoniae TIGR4 = SP1833; equivalent gene in S.pneumoniae R6 = spr1652; identified by match to protein family HMM PF04650; match to protein family HMM TIGR01168 YP_817070.1 equivalent gene in S.pneumoniae TIGR4 = SP1836; equivalent gene in S.pneumoniae R6 = spr1653 YP_817071.1 equivalent gene in S.pneumoniae TIGR4 = SP1837; equivalent gene in S.pneumoniae R6 = spr1654; identified by match to protein family HMM PF01041 YP_817072.1 equivalent gene in S.pneumoniae TIGR4 = SP1838; equivalent gene in S.pneumoniae R6 = spr1655; identified by match to protein family HMM PF02397 YP_817073.1 equivalent gene in S.pneumoniae TIGR4 = SP1839; equivalent gene in S.pneumoniae R6 = spr1656; identified by match to protein family HMM PF00005; match to protein family HMM PF00664 YP_817074.1 equivalent gene in S.pneumoniae TIGR4 = SP1840; equivalent gene in S.pneumoniae R6 = spr1657; identified by match to protein family HMM PF00005; match to protein family HMM PF00664 YP_817075.1 equivalent gene in S.pneumoniae TIGR4 = SP1841; equivalent gene in S.pneumoniae R6 = spr1658; identified by match to protein family HMM PF04239 YP_817076.1 equivalent gene in S.pneumoniae TIGR4 = SP1842; equivalent gene in S.pneumoniae R6 = spr1659 YP_817077.1 equivalent gene in S.pneumoniae TIGR4 = SP1844 YP_817078.1 equivalent gene in S.pneumoniae TIGR4 = SP1845; equivalent gene in S.pneumoniae R6 = spr1660; identified by match to protein family HMM PF03372; match to protein family HMM TIGR00195; match to protein family HMM TIGR00633 YP_817079.1 Catalyzes the transfer of the phosphoribosyl moiety from 5-phospho--D-ribosyl-1-pyrophosphate (PRib-PP) to the 6-oxo-guanine and -xanthine YP_817080.1 equivalent gene in S.pneumoniae TIGR4 = SP1848; equivalent gene in S.pneumoniae R6 = spr1663; identified by match to protein family HMM PF00860; match to protein family HMM PF00916; match to protein family HMM TIGR00801 YP_817081.1 equivalent gene in S.pneumoniae TIGR4 = SP1849; equivalent gene in S.pneumoniae R6 = spr1664 YP_817082.1 equivalent gene in S.pneumoniae TIGR4 = SP1850; equivalent gene in S.pneumoniae R6 = spr1665; identified by match to protein family HMM PF06044 YP_817083.1 equivalent gene in S.pneumoniae TIGR4 = SP1851; equivalent gene in S.pneumoniae R6 = spr1666; identified by match to protein family HMM PF03061; match to protein family HMM TIGR00369 YP_817084.1 catalyzes the formation of alpha-D-glucose 1-phosphate and UDP-galactose from UDP-glucose and alpha-D-galactose 1-phosphate in galactose metabolism YP_817085.1 catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism YP_817086.1 equivalent gene in S.pneumoniae TIGR4 = SP1854; equivalent gene in S.pneumoniae R6 = spr1669; identified by match to protein family HMM PF00356; match to protein family HMM PF00532 YP_817087.1 equivalent gene in S.pneumoniae TIGR4 = SP1855; equivalent gene in S.pneumoniae R6 = spr1670; identified by match to protein family HMM PF00107 YP_817088.1 equivalent gene in S.pneumoniae TIGR4 = SP1856; equivalent gene in S.pneumoniae R6 = spr1671; identified by match to protein family HMM PF00376 YP_817089.1 equivalent gene in S.pneumoniae TIGR4 = SP1857; equivalent gene in S.pneumoniae R6 = spr1672; identified by match to protein family HMM PF01545; match to protein family HMM TIGR01297 YP_817090.1 equivalent gene in S.pneumoniae TIGR4 = SP1858; equivalent gene in S.pneumoniae R6 = spr1673; identified by match to protein family HMM PF00440 YP_817091.1 equivalent gene in S.pneumoniae TIGR4 = SP1859; equivalent gene in S.pneumoniae R6 = spr1674; identified by match to protein family HMM PF04973; match to protein family HMM TIGR01528 YP_817092.1 equivalent gene in S.pneumoniae TIGR4 = SP1860; equivalent gene in S.pneumoniae R6 = spr1677; identified by match to protein family HMM PF00528; match to protein family HMM PF04069 YP_817093.1 equivalent gene in S.pneumoniae TIGR4 = SP1861; equivalent gene in S.pneumoniae R6 = spr1678; identified by match to protein family HMM PF00005 YP_817094.1 equivalent gene in S.pneumoniae TIGR4 = SP1862; equivalent gene in S.pneumoniae R6 = spr1679; identified by match to protein family HMM PF07366 YP_817095.1 equivalent gene in S.pneumoniae TIGR4 = SP1863; equivalent gene in S.pneumoniae R6 = spr1680; identified by match to protein family HMM PF01047 YP_817096.1 equivalent gene in S.pneumoniae TIGR4 = SP1864; equivalent gene in S.pneumoniae R6 = spr1681 YP_817097.1 equivalent gene in S.pneumoniae TIGR4 = SP1865; equivalent gene in S.pneumoniae R6 = spr1682; identified by match to protein family HMM PF05343 YP_817098.1 equivalent gene in S.pneumoniae TIGR4 = SP1867; equivalent gene in S.pneumoniae R6 = spr1683; identified by match to protein family HMM PF01073; match to protein family HMM PF01370; match to protein family HMM PF07993 YP_817099.1 equivalent gene in S.pneumoniae TIGR4 = SP1869; equivalent gene in S.pneumoniae R6 = spr1684; identified by match to protein family HMM PF01032 YP_817100.1 equivalent gene in S.pneumoniae TIGR4 = SP1870; equivalent gene in S.pneumoniae R6 = spr1685; identified by match to protein family HMM PF01032 YP_817101.1 equivalent gene in S.pneumoniae TIGR4 = SP1871; equivalent gene in S.pneumoniae R6 = spr1686; identified by match to protein family HMM PF00005 YP_817102.1 equivalent gene in S.pneumoniae TIGR4 = SP1872; equivalent gene in S.pneumoniae R6 = spr1687; identified by match to protein family HMM PF01497 YP_817103.1 equivalent gene in S.pneumoniae TIGR4 = SP1873; equivalent gene in S.pneumoniae R6 = spr1688; identified by match to protein family HMM PF01809; match to protein family HMM TIGR00278 YP_817104.1 equivalent gene in S.pneumoniae TIGR4 = SP1874; equivalent gene in S.pneumoniae R6 = spr1689; identified by match to protein family HMM PF00849; match to protein family HMM PF01479; match to protein family HMM TIGR00093 YP_817105.1 functions during chromosome segregation; may form a condensin-like structure with SMC and ScpA; forms a homodimer YP_817106.1 functions during chromosome segregation; may form a condensin-like structure with SMC and ScpB YP_817107.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs YP_817108.1 equivalent gene in S.pneumoniae TIGR4 = SP1878; equivalent gene in S.pneumoniae R6 = spr1693; identified by match to protein family HMM PF00571 YP_817109.1 equivalent gene in S.pneumoniae TIGR4 = SP1879; equivalent gene in S.pneumoniae R6 = spr1694; identified by match to protein family HMM PF00149; match to protein family HMM TIGR00040 YP_817110.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine YP_817111.1 converts L-glutamate to D-glutamate, a component of peptidoglycan YP_817112.1 equivalent gene in S.pneumoniae TIGR4 = SP1882; equivalent gene in S.pneumoniae R6 = spr1697 YP_817113.1 equivalent gene in S.pneumoniae TIGR4 = SP1883; equivalent gene in S.pneumoniae R6 = spr1698; identified by match to protein family HMM PF00128; match to protein family HMM TIGR02403 YP_817114.1 equivalent gene in S.pneumoniae TIGR4 = SP1884; equivalent gene in S.pneumoniae R6 = spr1699; identified by match to protein family HMM PF00358; match to protein family HMM PF00367; match to protein family HMM PF02378; match to protein family HMM TIGR00826; match to protein family HMM TIGR00830; match to protein family HMM TIGR01992 YP_817115.1 equivalent gene in S.pneumoniae TIGR4 = SP1885; equivalent gene in S.pneumoniae R6 = spr1700; identified by match to protein family HMM PF00392; match to protein family HMM PF07702; match to protein family HMM TIGR02404 YP_817116.1 equivalent gene in S.pneumoniae TIGR4 = SP1887; equivalent gene in S.pneumoniae R6 = spr1703; identified by match to protein family HMM PF00005 YP_817117.1 equivalent gene in S.pneumoniae TIGR4 = SP1888; equivalent gene in S.pneumoniae R6 = spr1704; identified by match to protein family HMM PF00005; match to protein family HMM TIGR01727 YP_817118.1 equivalent gene in S.pneumoniae TIGR4 = SP1889; equivalent gene in S.pneumoniae R6 = spr1705; identified by match to protein family HMM PF00528 YP_817119.1 equivalent gene in S.pneumoniae TIGR4 = SP1890; equivalent gene in S.pneumoniae R6 = spr1706; identified by match to protein family HMM PF00528 YP_817120.1 equivalent gene in S.pneumoniae TIGR4 = SP1891; equivalent gene in S.pneumoniae R6 = spr1707; identified by match to protein family HMM PF00496 YP_817121.1 equivalent gene in S.pneumoniae TIGR4 = SP1893; equivalent gene in S.pneumoniae R6 = spr1708; identified by match to protein family HMM PF04932 YP_817122.1 equivalent gene in S.pneumoniae TIGR4 = SP1894; equivalent gene in S.pneumoniae R6 = spr1709; identified by match to protein family HMM PF00128 YP_817124.1 equivalent gene in S.pneumoniae TIGR4 = SP1895; equivalent gene in S.pneumoniae R6 = spr1710; identified by match to protein family HMM PF00528 YP_817125.1 equivalent gene in S.pneumoniae TIGR4 = SP1896; equivalent gene in S.pneumoniae R6 = spr1711; identified by match to protein family HMM PF00528 YP_817126.1 equivalent gene in S.pneumoniae TIGR4 = SP1897; equivalent gene in S.pneumoniae R6 = spr1712; identified by match to protein family HMM PF01547 YP_817127.1 equivalent gene in S.pneumoniae TIGR4 = SP1898; equivalent gene in S.pneumoniae R6 = spr1713; identified by match to protein family HMM PF02065 YP_817128.1 equivalent gene in S.pneumoniae TIGR4 = SP1899; equivalent gene in S.pneumoniae R6 = spr1714; identified by match to protein family HMM PF00165; match to protein family HMM PF02311 YP_817129.1 catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon YP_817130.1 equivalent gene in S.pneumoniae TIGR4 = SP1901; equivalent gene in S.pneumoniae R6 = spr1717; identified by match to protein family HMM PF01938; match to protein family HMM PF05958; match to protein family HMM TIGR00479 YP_817131.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities YP_817132.1 equivalent gene in S.pneumoniae TIGR4 = SP1903; equivalent gene in S.pneumoniae R6 = spr1719; identified by match to protein family HMM PF04167 YP_817133.1 equivalent gene in S.pneumoniae TIGR4 = SP1904; equivalent gene in S.pneumoniae R6 = spr1720 YP_817134.1 equivalent gene in S.pneumoniae TIGR4 = SP1262; equivalent gene in S.pneumoniae R6 = spr1721; identified by match to protein family HMM PF01610 YP_817135.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth YP_817136.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring YP_817137.1 binds to single stranded DNA and may facilitate the binding and interaction of other proteins to DNA YP_817138.1 equivalent gene in S.pneumoniae TIGR4 = SP1909; equivalent gene in S.pneumoniae R6 = spr1725; identified by match to protein family HMM PF00106 YP_817139.1 equivalent gene in S.pneumoniae TIGR4 = SP1910; equivalent gene in S.pneumoniae R6 = spr1726; identified by match to protein family HMM PF01588 YP_817140.1 equivalent gene in S.pneumoniae TIGR4 = SP1911; equivalent gene in S.pneumoniae R6 = spr1727; identified by match to protein family HMM PF00085 YP_817141.1 equivalent gene in S.pneumoniae TIGR4 = SP1912; equivalent gene in S.pneumoniae R6 = spr1728 YP_817142.1 equivalent gene in S.pneumoniae R6 = spr1729; identified by match to protein family HMM PF01473 YP_817143.1 equivalent gene in S.pneumoniae TIGR4 = SP1914; equivalent gene in S.pneumoniae R6 = spr1730 YP_817144.1 equivalent gene in S.pneumoniae TIGR4 = SP1915; equivalent gene in S.pneumoniae R6 = spr1731; identified by match to protein family HMM PF04397 YP_817145.1 equivalent gene in S.pneumoniae TIGR4 = SP1916; equivalent gene in S.pneumoniae R6 = spr1732; identified by match to protein family HMM PF01569 YP_817146.1 equivalent gene in S.pneumoniae TIGR4 = SP1917; equivalent gene in S.pneumoniae R6 = spr1733 YP_817147.1 equivalent gene in S.pneumoniae TIGR4 = SP1918; equivalent gene in S.pneumoniae R6 = spr1734; identified by match to protein family HMM PF00005 YP_817149.1 equivalent gene in S.pneumoniae TIGR4 = SP1922; equivalent gene in S.pneumoniae R6 = spr1738; identified by match to protein family HMM PF01709; match to protein family HMM TIGR01033 YP_817150.1 equivalent gene in S.pneumoniae TIGR4 = SP1923; equivalent gene in S.pneumoniae R6 = spr1739; identified by match to protein family HMM PF01289 YP_817151.1 equivalent gene in S.pneumoniae TIGR4 = SP1924; equivalent gene in S.pneumoniae R6 = spr1740 YP_817152.1 equivalent gene in S.pneumoniae TIGR4 = SP1925; equivalent gene in S.pneumoniae R6 = spr1741 YP_817153.1 equivalent gene in S.pneumoniae TIGR4 = SP1926; equivalent gene in S.pneumoniae R6 = spr1742 This gene has a frameshift at amaino acid 96 relative to its R6 equivalent gene but not its TIGR4 equivalent gene. YP_817154.1 equivalent gene in S.pneumoniae TIGR4 = SP1930; equivalent gene in S.pneumoniae R6 = spr1746 YP_817155.1 equivalent gene in S.pneumoniae TIGR4 = SP1931; equivalent gene in S.pneumoniae R6 = spr1747 YP_817156.1 equivalent gene in S.pneumoniae TIGR4 = SP1932; equivalent gene in S.pneumoniae R6 = spr1748 YP_817157.1 equivalent gene in S.pneumoniae TIGR4 = SP1933; equivalent gene in S.pneumoniae R6 = spr1749 YP_817158.1 equivalent gene in S.pneumoniae TIGR4 = SP1934; equivalent gene in S.pneumoniae R6 = spr1750 YP_817159.1 equivalent gene in S.pneumoniae TIGR4 = SP1935; equivalent gene in S.pneumoniae R6 = spr1751 YP_817160.1 equivalent gene in S.pneumoniae TIGR4 = SP1937; equivalent gene in S.pneumoniae R6 = spr1754; identified by match to protein family HMM PF01473; match to protein family HMM PF01510 YP_817161.1 equivalent gene in S.pneumoniae TIGR4 = SP1939; equivalent gene in S.pneumoniae R6 = spr1756; identified by match to protein family HMM PF01554; match to protein family HMM TIGR00797 YP_817162.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs YP_817163.1 equivalent gene in S.pneumoniae TIGR4 = SP1941; equivalent gene in S.pneumoniae R6 = spr1758; identified by match to protein family HMM PF00994; match to protein family HMM PF02464; match to protein family HMM TIGR00199; match to protein family HMM TIGR00200 YP_817164.1 equivalent gene in S.pneumoniae TIGR4 = SP1942; equivalent gene in S.pneumoniae R6 = spr1759; identified by match to protein family HMM PF03816; match to protein family HMM TIGR00350 YP_817165.1 equivalent gene in S.pneumoniae TIGR4 = SP1943; equivalent gene in S.pneumoniae R6 = spr1760; identified by match to protein family HMM PF00583 YP_817166.1 equivalent gene in S.pneumoniae TIGR4 = SP1944; equivalent gene in S.pneumoniae R6 = spr1761; identified by match to protein family HMM PF02367; match to protein family HMM TIGR00150 YP_817167.1 equivalent gene in S.pneumoniae TIGR4 = SP1945; equivalent gene in S.pneumoniae R6 = spr1762 YP_817168.1 equivalent gene in S.pneumoniae TIGR4 = SP1946; equivalent gene in S.pneumoniae R6 = spr1763; identified by match to protein family HMM PF01381 YP_817169.1 equivalent gene in S.pneumoniae TIGR4 = SP1947; equivalent gene in S.pneumoniae R6 = spr1764 YP_817170.1 equivalent gene in S.pneumoniae TIGR4 = SP1948; equivalent gene in S.pneumoniae R6 = spr1765 YP_817171.1 equivalent gene in S.pneumoniae TIGR4 = SP1949; equivalent gene in S.pneumoniae R6 = spr1766 YP_817172.1 equivalent gene in S.pneumoniae TIGR4 = SP1950; equivalent gene in S.pneumoniae R6 = spr1767; identified by match to protein family HMM PF05147 YP_817173.1 equivalent gene in S.pneumoniae TIGR4 = SP1951; equivalent gene in S.pneumoniae R6 = spr1768 The crystal structure of this protein is published; identified by similarity to GB:1SQS_A YP_817174.1 equivalent gene in S.pneumoniae TIGR4 = SP1952; equivalent gene in S.pneumoniae R6 = spr1769 YP_817175.1 equivalent gene in S.pneumoniae TIGR4 = SP1953; equivalent gene in S.pneumoniae R6 = spr1770; identified by match to protein family HMM PF00005; match to protein family HMM PF00664; match to protein family HMM PF03412 YP_817176.1 equivalent gene in S.pneumoniae TIGR4 = SP1954; equivalent gene in S.pneumoniae R6 = spr1771; identified by match to protein family HMM PF00082 YP_817177.1 equivalent gene in S.pneumoniae TIGR4 = SP1956; equivalent gene in S.pneumoniae R6 = spr1772; identified by match to protein family HMM PF07242 YP_817178.1 equivalent gene in S.pneumoniae TIGR4 = SP1957; equivalent gene in S.pneumoniae R6 = spr1773; identified by match to protein family HMM PF00005 YP_817179.1 equivalent gene in S.pneumoniae TIGR4 = SP1958; equivalent gene in S.pneumoniae R6 = spr1774 YP_817180.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate YP_817181.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter YP_817182.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme YP_817183.1 equivalent gene in S.pneumoniae TIGR4 = SP1963; equivalent gene in S.pneumoniae R6 = spr1778; identified by match to protein family HMM PF00571; match to protein family HMM PF01595; match to protein family HMM PF03471 YP_817184.1 equivalent gene in S.pneumoniae TIGR4 = SP1964; equivalent gene in S.pneumoniae R6 = spr1779; identified by match to protein family HMM PF01223 YP_817185.1 equivalent gene in S.pneumoniae TIGR4 = SP1965; equivalent gene in S.pneumoniae R6 = spr1780 YP_817186.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_817187.1 equivalent gene in S.pneumoniae TIGR4 = SP1967; equivalent gene in S.pneumoniae R6 = spr1782 YP_817188.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA YP_817189.1 equivalent gene in S.pneumoniae TIGR4 = SP1969; equivalent gene in S.pneumoniae R6 = spr1784; identified by match to protein family HMM PF03602; match to protein family HMM TIGR00095 YP_817190.1 catalyzes the formation of asparagine from aspartate and ammonia YP_817191.1 equivalent gene in S.pneumoniae TIGR4 = SP1971; equivalent gene in S.pneumoniae R6 = spr1786 YP_817192.1 equivalent gene in S.pneumoniae TIGR4 = SP1972; equivalent gene in S.pneumoniae R6 = spr1787; identified by match to protein family HMM PF01027 YP_817193.1 equivalent gene in S.pneumoniae TIGR4 = SP1973; equivalent gene in S.pneumoniae R6 = spr1788; identified by match to protein family HMM PF00588; match to protein family HMM PF08032 YP_817194.1 catalyzes the hydrolysis of acylphosphate YP_817195.1 involved in biogenesis of membrane proteins; Firmicutes specific proteins are shorter than other bacterial counterparts and have a signal peptide and lipid attachment site YP_817196.1 equivalent gene in S.pneumoniae TIGR4 = SP1976; equivalent gene in S.pneumoniae R6 = spr1791; identified by match to protein family HMM PF04055; match to protein family HMM TIGR02493 YP_817197.1 equivalent gene in S.pneumoniae TIGR4 = SP1978; equivalent gene in S.pneumoniae R6 = spr1792; identified by match to protein family HMM PF00278; match to protein family HMM PF02784 YP_817198.1 equivalent gene in S.pneumoniae TIGR4 = SP1979; equivalent gene in S.pneumoniae R6 = spr1793; identified by match to protein family HMM PF00156; match to protein family HMM TIGR01743 YP_817199.1 equivalent gene in S.pneumoniae TIGR4 = SP1980; equivalent gene in S.pneumoniae R6 = spr1794; identified by match to protein family HMM PF01336 YP_817200.1 equivalent gene in S.pneumoniae TIGR4 = SP1981; equivalent gene in S.pneumoniae R6 = spr1795; identified by match to protein family HMM PF02646 YP_817201.1 equivalent gene in S.pneumoniae TIGR4 = SP1982; equivalent gene in S.pneumoniae R6 = spr1796; identified by match to protein family HMM PF04263; match to protein family HMM PF04265; match to protein family HMM TIGR01378 YP_817202.1 equivalent gene in S.pneumoniae TIGR4 = SP1983; equivalent gene in S.pneumoniae R6 = spr1797; identified by match to protein family HMM PF00834; match to protein family HMM TIGR01163 YP_817203.1 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity YP_817204.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin YP_817205.1 equivalent gene in S.pneumoniae TIGR4 = SP1986; equivalent gene in S.pneumoniae R6 = spr1800 YP_817206.1 equivalent gene in S.pneumoniae TIGR4 = SP1987; equivalent gene in S.pneumoniae R6 = spr1801; identified by match to protein family HMM PF00005 YP_817207.1 equivalent gene in S.pneumoniae TIGR4 = SP1988; equivalent gene in S.pneumoniae R6 = spr1802; identified by match to protein family HMM PF07242; match to protein family HMM TIGR01654 YP_817208.1 equivalent gene in S.pneumoniae TIGR4 = SP1989; equivalent gene in S.pneumoniae R6 = spr1803; identified by match to protein family HMM PF01381 YP_817209.1 equivalent gene in S.pneumoniae TIGR4 = SP1990; equivalent gene in S.pneumoniae R6 = spr1804; identified by match to protein family HMM PF01751; match to protein family HMM TIGR00334 YP_817210.1 equivalent gene in S.pneumoniae TIGR4 = SP1991; equivalent gene in S.pneumoniae R6 = spr1805; identified by match to protein family HMM PF01026; match to protein family HMM TIGR00010 YP_817211.1 equivalent gene in S.pneumoniae TIGR4 = SP1992; equivalent gene in S.pneumoniae R6 = spr1806; identified by match to protein family HMM PF00746; match to protein family HMM TIGR01167 YP_817212.1 in Escherichia coli transcription of this gene is enhanced by polyamines YP_817213.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor YP_817214.1 equivalent gene in S.pneumoniae TIGR4 = SP1995; equivalent gene in S.pneumoniae R6 = spr1809 YP_817215.1 equivalent gene in S.pneumoniae TIGR4 = SP1996; equivalent gene in S.pneumoniae R6 = spr1810; identified by match to protein family HMM PF00582 YP_817216.1 equivalent gene in S.pneumoniae TIGR4 = SP1997; equivalent gene in S.pneumoniae R6 = spr1811; identified by match to protein family HMM PF00702; match to protein family HMM PF05116; match to protein family HMM TIGR00099; match to protein family HMM TIGR01484 YP_817217.1 equivalent gene in S.pneumoniae TIGR4 = SP1998; equivalent gene in S.pneumoniae R6 = spr1812; identified by match to protein family HMM PF00710 YP_817219.1 equivalent gene in S.pneumoniae TIGR4 = SP1999; equivalent gene in S.pneumoniae R6 = spr1813; identified by match to protein family HMM PF00356; match to protein family HMM PF00532; match to protein family HMM TIGR01481 YP_817220.1 equivalent gene in S.pneumoniae TIGR4 = SP2000; equivalent gene in S.pneumoniae R6 = spr1814; identified by match to protein family HMM PF00072; match to protein family HMM PF00196 YP_817221.1 equivalent gene in S.pneumoniae TIGR4 = SP2001; equivalent gene in S.pneumoniae R6 = spr1815; identified by match to protein family HMM PF02518; match to protein family HMM PF07730 YP_817222.1 equivalent gene in S.pneumoniae TIGR4 = SP2002; equivalent gene in S.pneumoniae R6 = spr1816; identified by match to protein family HMM PF01061 YP_817223.1 equivalent gene in S.pneumoniae R6 = spr1817; identified by match to protein family HMM PF00005 YP_817225.1 equivalent gene in S.pneumoniae R6 = spr1818 YP_817226.1 equivalent gene in S.pneumoniae TIGR4 = SP0014; equivalent gene in S.pneumoniae R6 = spr0013 YP_817227.1 Modulates Rho-dependent transcription termination YP_817228.1 forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force YP_817229.1 equivalent gene in S.pneumoniae TIGR4 = SP2010; equivalent gene in S.pneumoniae R6 = spr1823; identified by match to protein family HMM PF00905; match to protein family HMM PF00912; match to protein family HMM TIGR02074 YP_817230.1 equivalent gene in S.pneumoniae TIGR4 = SP2011; equivalent gene in S.pneumoniae R6 = spr1824; identified by match to protein family HMM PF00849 YP_817231.1 equivalent gene in S.pneumoniae TIGR4 = SP2012; equivalent gene in S.pneumoniae R6 = spr1825; identified by match to protein family HMM PF00044; match to protein family HMM PF02800; match to protein family HMM TIGR01534 YP_817232.1 equivalent gene in S.pneumoniae TIGR4 = SP2013; equivalent gene in S.pneumoniae R6 = spr1826; identified by match to protein family HMM PF02687 YP_817233.1 catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide YP_817234.1 equivalent gene in S.pneumoniae TIGR4 = SP2017; equivalent gene in S.pneumoniae R6 = spr1830; identified by match to protein family HMM PF03600; match to protein family HMM PF07158 YP_817235.1 equivalent gene in S.pneumoniae TIGR4 = SP2019; equivalent gene in S.pneumoniae R6 = spr1831 YP_817236.1 equivalent gene in S.pneumoniae TIGR4 = SP2020; equivalent gene in S.pneumoniae R6 = spr1832; identified by match to protein family HMM PF00392; match to protein family HMM PF07702 YP_817237.1 equivalent gene in S.pneumoniae TIGR4 = SP2021; equivalent gene in S.pneumoniae R6 = spr1833; identified by match to protein family HMM PF00232 YP_817238.1 equivalent gene in S.pneumoniae TIGR4 = SP2022; equivalent gene in S.pneumoniae R6 = spr1834; identified by match to protein family HMM PF02378; match to protein family HMM TIGR00410 YP_817239.1 equivalent gene in S.pneumoniae TIGR4 = SP2023; equivalent gene in S.pneumoniae R6 = spr1835; identified by match to protein family HMM PF02302 YP_817240.1 equivalent gene in S.pneumoniae TIGR4 = SP2024; equivalent gene in S.pneumoniae R6 = spr1836; identified by match to protein family HMM PF02255 YP_817241.1 equivalent gene in S.pneumoniae TIGR4 = SP2026; equivalent gene in S.pneumoniae R6 = spr1837; identified by match to protein family HMM PF00465 YP_817243.1 equivalent gene in S.pneumoniae TIGR4 = SP2027; equivalent gene in S.pneumoniae R6 = spr1838; identified by match to protein family HMM PF02493 YP_817244.1 equivalent gene in S.pneumoniae TIGR4 = SP2028; equivalent gene in S.pneumoniae R6 = spr1839; identified by match to protein family HMM PF01451 YP_817245.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex YP_817246.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase YP_817247.1 equivalent gene in S.pneumoniae TIGR4 = SP2031; equivalent gene in S.pneumoniae R6 = spr1842 YP_817248.1 equivalent gene in S.pneumoniae TIGR4 = SP2032; equivalent gene in S.pneumoniae R6 = spr1843; identified by match to protein family HMM PF00874 YP_817249.1 catalyzes the formation of D-xylulose 5-phosphate from L-ribulose 5-phosphate in the L-arabinose and L-ascorbate degradation pathways YP_817250.1 L-xylulose 5-phosphate 3-epimerase activity not yet demonstrated; may be involved in the utilization of 2,3-diketo-L-gulonate YP_817251.1 catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization YP_817252.1 equivalent gene in S.pneumoniae TIGR4 = SP2036; equivalent gene in S.pneumoniae R6 = spr1847; identified by match to protein family HMM PF00359 YP_817253.1 equivalent gene in S.pneumoniae TIGR4 = SP2037; equivalent gene in S.pneumoniae R6 = spr1848; identified by match to protein family HMM PF02302 YP_817254.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr YP_817255.1 equivalent gene in S.pneumoniae TIGR4 = SP2039; equivalent gene in S.pneumoniae R6 = spr1850 YP_817256.1 equivalent gene in S.pneumoniae TIGR4 = SP2040; equivalent gene in S.pneumoniae R6 = spr1851; identified by match to protein family HMM PF01424 YP_817257.1 equivalent gene in S.pneumoniae TIGR4 = SP2041; equivalent gene in S.pneumoniae R6 = spr1852; identified by match to protein family HMM PF02096 YP_817258.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates YP_817259.1 equivalent gene in S.pneumoniae TIGR4 = SP2043 YP_817260.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA YP_817261.1 equivalent gene in S.pneumoniae TIGR4 = SP2045; equivalent gene in S.pneumoniae R6 = spr1855 YP_817262.1 equivalent gene in S.pneumoniae R6 = spr1856 YP_817263.1 equivalent gene in S.pneumoniae R6 = spr1857 YP_817264.1 equivalent gene in S.pneumoniae TIGR4 = SP2047; equivalent gene in S.pneumoniae R6 = spr1858 YP_817265.1 equivalent gene in S.pneumoniae TIGR4 = SP2048; equivalent gene in S.pneumoniae R6 = spr1859 YP_817266.1 equivalent gene in S.pneumoniae TIGR4 = SP2049 YP_817267.1 equivalent gene in S.pneumoniae TIGR4 = SP2050; equivalent gene in S.pneumoniae R6 = spr1861; identified by match to protein family HMM TIGR02532 YP_817268.1 equivalent gene in S.pneumoniae TIGR4 = SP2051; equivalent gene in S.pneumoniae R6 = spr1862; identified by match to protein family HMM PF07963; match to protein family HMM TIGR02532 YP_817269.1 equivalent gene in S.pneumoniae TIGR4 = SP2052; equivalent gene in S.pneumoniae R6 = spr1863; identified by match to protein family HMM PF00482 YP_817270.1 equivalent gene in S.pneumoniae TIGR4 = SP2053; equivalent gene in S.pneumoniae R6 = spr1864; identified by match to protein family HMM PF00437 YP_817271.1 equivalent gene in S.pneumoniae TIGR4 = SP2054; equivalent gene in S.pneumoniae R6 = spr1865; identified by match to protein family HMM PF06279 YP_817272.1 equivalent gene in S.pneumoniae TIGR4 = SP2055; equivalent gene in S.pneumoniae R6 = spr1866; identified by match to protein family HMM PF00107 YP_817273.1 equivalent gene in S.pneumoniae TIGR4 = SP2056; equivalent gene in S.pneumoniae R6 = spr1867; identified by match to protein family HMM PF01979; match to protein family HMM TIGR00221 YP_817274.1 equivalent gene in S.pneumoniae TIGR4 = SP2057; equivalent gene in S.pneumoniae R6 = spr1868; identified by match to protein family HMM PF01757 YP_817275.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr) YP_817276.1 equivalent gene in S.pneumoniae TIGR4 = SP2059; equivalent gene in S.pneumoniae R6 = spr1870; identified by match to protein family HMM PF06161 YP_817277.1 equivalent gene in S.pneumoniae TIGR4 = SP2061; equivalent gene in S.pneumoniae R6 = spr1873; identified by match to protein family HMM PF06993 YP_817279.1 equivalent gene in S.pneumoniae TIGR4 = SP2063; equivalent gene in S.pneumoniae R6 = spr1875; identified by match to protein family HMM PF01476 YP_817280.1 equivalent gene in S.pneumoniae TIGR4 = SP2064; equivalent gene in S.pneumoniae R6 = spr1876; identified by match to protein family HMM PF00702; match to protein family HMM TIGR01549 YP_817281.1 equivalent gene in S.pneumoniae TIGR4 = SP2065; equivalent gene in S.pneumoniae R6 = spr1877; identified by match to protein family HMM PF01554; match to protein family HMM TIGR00797 YP_817282.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine YP_817283.1 equivalent gene in S.pneumoniae TIGR4 = SP2067; equivalent gene in S.pneumoniae R6 = spr1879 YP_817284.1 equivalent gene in S.pneumoniae TIGR4 = SP2068; equivalent gene in S.pneumoniae R6 = spr1880; identified by match to protein family HMM PF00383 YP_817285.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_817286.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family YP_817287.1 equivalent gene in S.pneumoniae TIGR4 = SP2071; equivalent gene in S.pneumoniae R6 = spr1883 YP_817288.1 equivalent gene in S.pneumoniae TIGR4 = SP2072; equivalent gene in S.pneumoniae R6 = spr1884; identified by match to protein family HMM PF00117; match to protein family HMM PF07722 YP_817289.1 equivalent gene in S.pneumoniae TIGR4 = SP2073; equivalent gene in S.pneumoniae R6 = spr1885; identified by match to protein family HMM PF00005; match to protein family HMM PF00664 YP_817290.1 equivalent gene in S.pneumoniae R6 = spr1886 YP_817291.1 equivalent gene in S.pneumoniae TIGR4 = SP2075; equivalent gene in S.pneumoniae R6 = spr1887; identified by match to protein family HMM PF00005; match to protein family HMM PF00664 YP_817292.1 This protein performs the mismatch recognition step during the DNA repair process YP_817293.1 equivalent gene in S.pneumoniae TIGR4 = SP2077; equivalent gene in S.pneumoniae R6 = spr1889; identified by match to protein family HMM PF01316; match to protein family HMM PF02863; match to protein family HMM TIGR01529 YP_817294.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase YP_817295.1 equivalent gene in S.pneumoniae TIGR4 = SP1086; equivalent gene in S.pneumoniae R6 = spr1891; identified by match to protein family HMM PF01609 YP_817296.1 equivalent gene in S.pneumoniae TIGR4 = SP2081; equivalent gene in S.pneumoniae R6 = spr1892; identified by match to protein family HMM PF06172 YP_817297.1 equivalent gene in S.pneumoniae TIGR4 = SP2082; equivalent gene in S.pneumoniae R6 = spr1893; identified by match to protein family HMM PF00072; match to protein family HMM PF00486 YP_817298.1 equivalent gene in S.pneumoniae TIGR4 = SP2083; equivalent gene in S.pneumoniae R6 = spr1894; identified by match to protein family HMM PF00512; match to protein family HMM PF02518 YP_817299.1 equivalent gene in S.pneumoniae TIGR4 = SP2084; equivalent gene in S.pneumoniae R6 = spr1895 YP_817300.1 equivalent gene in S.pneumoniae TIGR4 = SP2085; equivalent gene in S.pneumoniae R6 = spr1896; identified by match to protein family HMM PF00528; match to protein family HMM TIGR02138 YP_817301.1 equivalent gene in S.pneumoniae TIGR4 = SP2086; equivalent gene in S.pneumoniae R6 = spr1897; identified by match to protein family HMM PF00528; match to protein family HMM TIGR00974 YP_817302.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation YP_817303.1 equivalent gene in S.pneumoniae TIGR4 = SP2088; equivalent gene in S.pneumoniae R6 = spr1899; identified by match to protein family HMM PF01895; match to protein family HMM TIGR02135 YP_817304.1 equivalent gene in S.pneumoniae TIGR4 = SP2090; equivalent gene in S.pneumoniae R6 = spr1901; identified by match to protein family HMM PF01381 YP_817306.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate YP_817307.1 equivalent gene in S.pneumoniae TIGR4 = SP2092; equivalent gene in S.pneumoniae R6 = spr1903; identified by match to protein family HMM PF00483; match to protein family HMM TIGR01099 YP_817308.1 equivalent gene in S.pneumoniae TIGR4 = SP2094; equivalent gene in S.pneumoniae R6 = spr1904; identified by match to protein family HMM PF01694 YP_817309.1 equivalent gene in S.pneumoniae TIGR4 = SP2095; equivalent gene in S.pneumoniae R6 = spr1905; identified by match to protein family HMM PF01812; match to protein family HMM TIGR02727 YP_817310.1 equivalent gene in S.pneumoniae TIGR4 = SP2096; equivalent gene in S.pneumoniae R6 = spr1906; identified by match to protein family HMM PF01546; match to protein family HMM PF07687; match to protein family HMM TIGR01891 YP_817311.1 equivalent gene in S.pneumoniae TIGR4 = SP2097; equivalent gene in S.pneumoniae R6 = spr1907; identified by match to protein family HMM PF00132 YP_817312.1 equivalent gene in S.pneumoniae TIGR4 = SP2098; equivalent gene in S.pneumoniae R6 = spr1908; identified by match to protein family HMM PF00892 YP_817313.1 equivalent gene in S.pneumoniae TIGR4 = SP2099; equivalent gene in S.pneumoniae R6 = spr1909; identified by match to protein family HMM PF00905; match to protein family HMM PF00912 YP_817314.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr) YP_817315.1 equivalent gene in S.pneumoniae TIGR4 = SP2101; equivalent gene in S.pneumoniae R6 = spr1911; identified by match to protein family HMM PF00122; match to protein family HMM PF00702; match to protein family HMM TIGR01494; match to protein family HMM TIGR01512; match to protein family HMM TIGR01525 YP_817316.1 equivalent gene in S.pneumoniae TIGR4 = SP2102; equivalent gene in S.pneumoniae R6 = spr1912 YP_817317.1 equivalent gene in S.pneumoniae TIGR4 = SP2103; equivalent gene in S.pneumoniae R6 = spr1913 YP_817318.1 equivalent gene in S.pneumoniae TIGR4 = SP2104; equivalent gene in S.pneumoniae R6 = spr1914 YP_817319.1 equivalent gene in S.pneumoniae TIGR4 = SP2105; equivalent gene in S.pneumoniae R6 = spr1915 YP_817320.1 equivalent gene in S.pneumoniae TIGR4 = SP2106; equivalent gene in S.pneumoniae R6 = spr1916; identified by match to protein family HMM PF00343; match to protein family HMM TIGR02093 YP_817321.1 amylomaltase; acts to release glucose from maltodextrins YP_817322.1 equivalent gene in S.pneumoniae TIGR4 = SP2108; equivalent gene in S.pneumoniae R6 = spr1918; identified by match to protein family HMM PF01547 YP_817323.1 equivalent gene in S.pneumoniae TIGR4 = SP2109; equivalent gene in S.pneumoniae R6 = spr1919; identified by match to protein family HMM PF00528; match to protein family HMM PF05154 YP_817324.1 equivalent gene in S.pneumoniae TIGR4 = SP2110; equivalent gene in S.pneumoniae R6 = spr1920; identified by match to protein family HMM PF00528 YP_817325.1 equivalent gene in S.pneumoniae TIGR4 = SP2111; equivalent gene in S.pneumoniae R6 = spr1921 YP_817326.1 equivalent gene in S.pneumoniae TIGR4 = SP2112; equivalent gene in S.pneumoniae R6 = spr1922; identified by match to protein family HMM PF00356; match to protein family HMM PF00532 YP_817328.1 equivalent gene in S.pneumoniae TIGR4 = SP2113; equivalent gene in S.pneumoniae R6 = spr1923; identified by match to protein family HMM PF02588 YP_817329.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes YP_817331.1 equivalent gene in S.pneumoniae TIGR4 = SP2115; equivalent gene in S.pneumoniae R6 = spr1925 YP_817332.1 equivalent gene in S.pneumoniae TIGR4 = SP2116; equivalent gene in S.pneumoniae R6 = spr1926; identified by match to protein family HMM PF02517 YP_817333.1 equivalent gene in S.pneumoniae TIGR4 = SP2117; equivalent gene in S.pneumoniae R6 = spr1927 YP_817334.1 equivalent gene in S.pneumoniae TIGR4 = SP2118; equivalent gene in S.pneumoniae R6 = spr1928 YP_817335.1 equivalent gene in S.pneumoniae TIGR4 = SP2119; equivalent gene in S.pneumoniae R6 = spr1929; identified by match to protein family HMM PF01381 YP_817336.1 equivalent gene in S.pneumoniae R6 = spr1930 YP_817338.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG YP_817339.1 equivalent gene in S.pneumoniae TIGR4 = SP2122; equivalent gene in S.pneumoniae R6 = spr1932; identified by match to protein family HMM PF07690 YP_817340.1 equivalent gene in S.pneumoniae R6 = spr1933; identified by match to protein family HMM TIGR01716 YP_817341.1 equivalent gene in S.pneumoniae TIGR4 = SP2124 YP_817342.1 equivalent gene in S.pneumoniae TIGR4 = SP2125; equivalent gene in S.pneumoniae R6 = spr1934; identified by match to protein family HMM PF01883 YP_817344.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis YP_817345.1 equivalent gene in S.pneumoniae TIGR4 = SP2127; equivalent gene in S.pneumoniae R6 = spr1936; identified by match to protein family HMM PF02779; match to protein family HMM PF02780 YP_817346.1 equivalent gene in S.pneumoniae TIGR4 = SP2128; equivalent gene in S.pneumoniae R6 = spr1937; identified by match to protein family HMM PF00456 YP_817347.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr YP_817348.1 equivalent gene in S.pneumoniae TIGR4 = SP2130; equivalent gene in S.pneumoniae R6 = spr1939; identified by match to protein family HMM PF02302 YP_817349.1 equivalent gene in S.pneumoniae TIGR4 = SP2131; equivalent gene in S.pneumoniae R6 = spr1940; identified by match to protein family HMM PF00359; match to protein family HMM PF00874 YP_817350.1 equivalent gene in S.pneumoniae TIGR4 = SP2132; equivalent gene in S.pneumoniae R6 = spr1941; identified by match to protein family HMM PF01145 YP_817351.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not YP_817352.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif YP_817353.1 equivalent gene in S.pneumoniae TIGR4 = SP2136; equivalent gene in S.pneumoniae R6 = spr1945; identified by match to protein family HMM PF01473 YP_817354.1 equivalent gene in S.pneumoniae TIGR4 = SP0537; equivalent gene in S.pneumoniae R6 = spr1946; identified by match to protein family HMM PF04326 YP_817355.1 equivalent gene in S.pneumoniae TIGR4 = SP1086; equivalent gene in S.pneumoniae R6 = spr1947; identified by match to protein family HMM PF01609 YP_817356.1 equivalent gene in S.pneumoniae TIGR4 = SP2139; equivalent gene in S.pneumoniae R6 = spr1948 YP_817357.1 equivalent gene in S.pneumoniae TIGR4 = SP2141; equivalent gene in S.pneumoniae R6 = spr1949; identified by match to protein family HMM PF00728 YP_817358.1 equivalent gene in S.pneumoniae TIGR4 = SP2142; equivalent gene in S.pneumoniae R6 = spr1950; identified by match to protein family HMM PF00480 YP_817359.1 equivalent gene in S.pneumoniae TIGR4 = SP2143; equivalent gene in S.pneumoniae R6 = spr1951; identified by match to protein family HMM PF01074; match to protein family HMM PF07748 YP_817360.1 equivalent gene in S.pneumoniae TIGR4 = SP2144; equivalent gene in S.pneumoniae R6 = spr1952; identified by match to protein family HMM PF06824 YP_817361.1 equivalent gene in S.pneumoniae TIGR4 = SP2145; equivalent gene in S.pneumoniae R6 = spr1953; identified by match to protein family HMM PF07971; match to protein family HMM TIGR01180 YP_817362.1 equivalent gene in S.pneumoniae TIGR4 = SP2146; equivalent gene in S.pneumoniae R6 = spr1954; identified by match to protein family HMM PF00754 YP_817363.1 catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway YP_817364.1 catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP YP_817365.1 equivalent gene in S.pneumoniae TIGR4 = SP2152; equivalent gene in S.pneumoniae R6 = spr1959; identified by match to protein family HMM PF03606 YP_817366.1 equivalent gene in S.pneumoniae TIGR4 = SP2153; equivalent gene in S.pneumoniae R6 = spr1960; identified by match to protein family HMM PF01546; match to protein family HMM TIGR01887 YP_817367.1 equivalent gene in S.pneumoniae R6 = spr1961 YP_817369.1 equivalent gene in S.pneumoniae R6 = spr1214 YP_817370.1 equivalent gene in S.pneumoniae TIGR4 = SP2156; equivalent gene in S.pneumoniae R6 = spr1962; identified by match to protein family HMM PF01145 YP_817371.1 equivalent gene in S.pneumoniae TIGR4 = SP2157; equivalent gene in S.pneumoniae R6 = spr1963; identified by match to protein family HMM PF00465 YP_817372.1 catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose YP_817373.1 equivalent gene in S.pneumoniae TIGR4 = SP2159; equivalent gene in S.pneumoniae R6 = spr1965; identified by match to protein family HMM PF00754 YP_817374.1 equivalent gene in S.pneumoniae TIGR4 = SP2160; equivalent gene in S.pneumoniae R6 = spr1966 YP_817375.1 equivalent gene in S.pneumoniae TIGR4 = SP2161; equivalent gene in S.pneumoniae R6 = spr1967; identified by match to protein family HMM PF03613 YP_817376.1 equivalent gene in S.pneumoniae TIGR4 = SP2162; equivalent gene in S.pneumoniae R6 = spr1968; identified by match to protein family HMM PF03609 YP_817377.1 equivalent gene in S.pneumoniae TIGR4 = SP2163; equivalent gene in S.pneumoniae R6 = spr1969; identified by match to protein family HMM PF03830 YP_817378.1 equivalent gene in S.pneumoniae TIGR4 = SP2164; equivalent gene in S.pneumoniae R6 = spr1970; identified by match to protein family HMM PF03610 YP_817379.1 equivalent gene in S.pneumoniae TIGR4 = SP2165; equivalent gene in S.pneumoniae R6 = spr1971; identified by match to protein family HMM PF05025 YP_817380.1 catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate YP_817381.1 equivalent gene in S.pneumoniae TIGR4 = SP2167; equivalent gene in S.pneumoniae R6 = spr1973; identified by match to protein family HMM PF00370; match to protein family HMM PF02782 YP_817382.1 equivalent gene in S.pneumoniae TIGR4 = SP2168; equivalent gene in S.pneumoniae R6 = spr1974; identified by match to protein family HMM PF00455; match to protein family HMM PF08220 YP_817383.1 equivalent gene in S.pneumoniae TIGR4 = SP2169; equivalent gene in S.pneumoniae R6 = spr1975; identified by match to protein family HMM PF01297 YP_817384.1 equivalent gene in S.pneumoniae TIGR4 = SP2170; equivalent gene in S.pneumoniae R6 = spr1976; identified by match to protein family HMM PF00950 YP_817385.1 equivalent gene in S.pneumoniae TIGR4 = SP2171; equivalent gene in S.pneumoniae R6 = spr1977; identified by match to protein family HMM PF00005 YP_817386.1 equivalent gene in S.pneumoniae TIGR4 = SP2172; equivalent gene in S.pneumoniae R6 = spr1978; identified by match to protein family HMM PF01022; match to protein family HMM PF01047; match to protein family HMM PF01325; match to protein family HMM PF01978 YP_817388.1 equivalent gene in S.pneumoniae TIGR4 = SP2173; equivalent gene in S.pneumoniae R6 = spr1979; identified by match to protein family HMM PF04914; match to protein family HMM PF04915; match to protein family HMM PF04918 YP_817389.1 D-alanyl carrier protein subunit; involved in the incorporation of D-alanine into membrane-associated D-alanyl-lipoteichoic acid; D-alanyl carrier protein is the acceptor of activated D-alanine which it donates to a membrane acceptor(D-alanyl transferase) for incorporation into membrane lipoteichoic acid YP_817390.1 equivalent gene in S.pneumoniae TIGR4 = SP2175; equivalent gene in S.pneumoniae R6 = spr1981; identified by match to protein family HMM PF03062 YP_817391.1 transfers D-alanine to the D-alanyl carrier protein during the incorporation of D-alanine into lipoteichoic acid YP_817392.1 equivalent gene in S.pneumoniae TIGR4 = SP2177 YP_817393.1 equivalent gene in S.pneumoniae TIGR4 = SP2180; equivalent gene in S.pneumoniae R6 = spr1983; identified by match to protein family HMM PF07690 YP_817394.1 equivalent gene in S.pneumoniae TIGR4 = SP2182; equivalent gene in S.pneumoniae R6 = spr1986 YP_817395.1 equivalent gene in S.pneumoniae TIGR4 = SP2183; equivalent gene in S.pneumoniae R6 = spr1987 YP_817396.1 equivalent gene in S.pneumoniae TIGR4 = SP2184; equivalent gene in S.pneumoniae R6 = spr1988; identified by match to protein family HMM PF00230; match to protein family HMM TIGR00861 YP_817397.1 equivalent gene in S.pneumoniae TIGR4 = SP2185; equivalent gene in S.pneumoniae R6 = spr1990; identified by match to protein family HMM PF01266 YP_817398.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP YP_817399.1 equivalent gene in S.pneumoniae TIGR4 = SP2187; equivalent gene in S.pneumoniae R6 = spr1992; identified by match to protein family HMM PF05043 YP_817400.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers YP_817401.1 equivalent gene in S.pneumoniae TIGR4 = SP2189; equivalent gene in S.pneumoniae R6 = spr1994; identified by match to protein family HMM PF01180; match to protein family HMM PF01207; match to protein family HMM TIGR00737 YP_817402.1 equivalent gene in S.pneumoniae R6 = spr1995 This gene is also called SpsA, pspC (pneumococcal surface protein C)and Hic; identified by match to protein family HMM PF01473; match to protein family HMM PF04650; match to protein family HMM PF05062; match to protein family HMM TIGR01168 YP_817403.1 equivalent gene in S.pneumoniae TIGR4 = SP2191; equivalent gene in S.pneumoniae R6 = spr1996; identified by match to protein family HMM PF04140 YP_817404.1 equivalent gene in S.pneumoniae TIGR4 = SP2192; equivalent gene in S.pneumoniae R6 = spr1997; identified by match to protein family HMM PF00512; match to protein family HMM PF00672; match to protein family HMM PF02518 YP_817405.1 equivalent gene in S.pneumoniae TIGR4 = SP2193; equivalent gene in S.pneumoniae R6 = spr1998; identified by match to protein family HMM PF00072; match to protein family HMM PF00486 YP_817407.1 equivalent gene in S.pneumoniae TIGR4 = SP2194; equivalent gene in S.pneumoniae R6 = spr2000; identified by match to protein family HMM PF00004; match to protein family HMM PF02861; match to protein family HMM PF07724; match to protein family HMM PF07728 YP_817408.1 equivalent gene in S.pneumoniae TIGR4 = SP2195; equivalent gene in S.pneumoniae R6 = spr2001; identified by match to protein family HMM PF05848 YP_817409.1 equivalent gene in S.pneumoniae TIGR4 = SP2196; equivalent gene in S.pneumoniae R6 = spr2002; identified by match to protein family HMM PF00005 YP_817410.1 equivalent gene in S.pneumoniae TIGR4 = SP2197; equivalent gene in S.pneumoniae R6 = spr2003 YP_817411.1 equivalent gene in S.pneumoniae TIGR4 = SP2198; equivalent gene in S.pneumoniae R6 = spr2004; identified by match to protein family HMM PF00528 YP_817412.1 equivalent gene in S.pneumoniae TIGR4 = SP2199; equivalent gene in S.pneumoniae R6 = spr2005 YP_817413.1 equivalent gene in S.pneumoniae TIGR4 = SP2201; equivalent gene in S.pneumoniae R6 = spr2006; identified by match to protein family HMM PF01473; match to protein family HMM PF05257 YP_817414.1 equivalent gene in S.pneumoniae TIGR4 = SP2202; equivalent gene in S.pneumoniae R6 = spr2007; identified by match to protein family HMM PF06257 YP_817415.1 unwinds double stranded DNA YP_817416.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk YP_817417.1 equivalent gene in S.pneumoniae TIGR4 = SP2205; equivalent gene in S.pneumoniae R6 = spr2010; identified by match to protein family HMM PF01368; match to protein family HMM PF02272 YP_817418.1 equivalent gene in S.pneumoniae TIGR4 = SP2206; equivalent gene in S.pneumoniae R6 = spr2011; identified by match to protein family HMM PF02482; match to protein family HMM TIGR00741 YP_817419.1 equivalent gene in S.pneumoniae TIGR4 = SP2207; equivalent gene in S.pneumoniae R6 = spr2012 YP_817420.1 equivalent gene in S.pneumoniae TIGR4 = SP2208; equivalent gene in S.pneumoniae R6 = spr2013; identified by match to protein family HMM PF00271; match to protein family HMM PF04851 YP_817421.1 equivalent gene in S.pneumoniae TIGR4 = SP2209; equivalent gene in S.pneumoniae R6 = spr2014; identified by match to protein family HMM PF01205; match to protein family HMM TIGR00257 YP_817422.1 equivalent gene in S.pneumoniae TIGR4 = SP2210; equivalent gene in S.pneumoniae R6 = spr2015; identified by match to protein family HMM PF00291; match to protein family HMM TIGR01136; match to protein family HMM TIGR01139 YP_817423.1 equivalent gene in S.pneumoniae R6 = spr2016 YP_817424.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu YP_817425.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit YP_817426.1 equivalent gene in S.pneumoniae TIGR4 = SP2216; equivalent gene in S.pneumoniae R6 = spr2021; identified by match to protein family HMM PF05257 YP_817427.1 equivalent gene in S.pneumoniae TIGR4 = SP2217; equivalent gene in S.pneumoniae R6 = spr2022; identified by match to protein family HMM PF04093 YP_817428.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall YP_817429.1 equivalent gene in S.pneumoniae TIGR4 = SP2219; equivalent gene in S.pneumoniae R6 = spr2024; identified by match to protein family HMM PF02361 YP_817430.1 with CbiNQ forms the ABC transporter for cobalt import; Streptococcus has two adjacent copies of this gene YP_817431.1 with CbiNQ forms the ABC transporter for cobalt import; Streptococcus has two adjacent copies of this gene YP_817432.1 equivalent gene in S.pneumoniae TIGR4 = SP2222; equivalent gene in S.pneumoniae R6 = spr2027; identified by match to protein family HMM PF01066; match to protein family HMM TIGR00560 YP_817433.1 equivalent gene in S.pneumoniae TIGR4 = SP2223; equivalent gene in S.pneumoniae R6 = spr2028 YP_817434.1 equivalent gene in S.pneumoniae TIGR4 = SP2224; equivalent gene in S.pneumoniae R6 = spr2029; identified by match to protein family HMM PF00675; match to protein family HMM PF05193 YP_817435.1 equivalent gene in S.pneumoniae TIGR4 = SP2225; equivalent gene in S.pneumoniae R6 = spr2030; identified by match to protein family HMM PF05193 YP_817436.1 equivalent gene in S.pneumoniae TIGR4 = SP2226; equivalent gene in S.pneumoniae R6 = spr2031 YP_817437.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA YP_817438.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate YP_817439.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_817440.1 equivalent gene in S.pneumoniae TIGR4 = SP2230; equivalent gene in S.pneumoniae R6 = spr2035; identified by match to protein family HMM PF00005 YP_817441.1 equivalent gene in S.pneumoniae TIGR4 = SP2231; equivalent gene in S.pneumoniae R6 = spr2036 YP_817442.1 equivalent gene in S.pneumoniae TIGR4 = SP2234; equivalent gene in S.pneumoniae R6 = spr2040; identified by match to protein family HMM PF00440 YP_817443.1 equivalent gene in S.pneumoniae TIGR4 = SP2235; equivalent gene in S.pneumoniae R6 = spr2041; identified by match to protein family HMM PF00072; match to protein family HMM PF04397 YP_817444.1 equivalent gene in S.pneumoniae TIGR4 = SP2236; equivalent gene in S.pneumoniae R6 = spr2042; identified by match to protein family HMM PF02518 YP_817445.1 equivalent gene in S.pneumoniae R6 = spr2043; identified by match to protein family HMM PF03047 YP_817446.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA YP_817447.1 equivalent gene in S.pneumoniae TIGR4 = SP2239; equivalent gene in S.pneumoniae R6 = spr2045; identified by match to protein family HMM PF00089 YP_817448.1 equivalent gene in S.pneumoniae TIGR4 = SP2240; equivalent gene in S.pneumoniae R6 = spr2046; identified by match to protein family HMM PF02195; match to protein family HMM TIGR00180