-- dump date   	20140620_084513
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
373153000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
373153000002	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
373153000003	Walker A motif; other site
373153000004	ATP binding site [chemical binding]; other site
373153000005	Walker B motif; other site
373153000006	arginine finger; other site
373153000007	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
373153000008	DnaA box-binding interface [nucleotide binding]; other site
373153000009	DNA polymerase III subunit beta; Validated; Region: PRK05643
373153000010	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
373153000011	putative DNA binding surface [nucleotide binding]; other site
373153000012	dimer interface [polypeptide binding]; other site
373153000013	beta-clamp/clamp loader binding surface; other site
373153000014	beta-clamp/translesion DNA polymerase binding surface; other site
373153000015	Bacterial protein of unknown function (DUF951); Region: DUF951; cl01864
373153000016	GTP-binding protein YchF; Reviewed; Region: PRK09601
373153000017	YchF GTPase; Region: YchF; cd01900
373153000018	G1 box; other site
373153000019	GTP/Mg2+ binding site [chemical binding]; other site
373153000020	Switch I region; other site
373153000021	G2 box; other site
373153000022	Switch II region; other site
373153000023	G3 box; other site
373153000024	G4 box; other site
373153000025	G5 box; other site
373153000026	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
373153000027	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
373153000028	putative active site [active]
373153000029	catalytic residue [active]
373153000030	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
373153000031	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
373153000032	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
373153000033	ATP binding site [chemical binding]; other site
373153000034	putative Mg++ binding site [ion binding]; other site
373153000035	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
373153000036	nucleotide binding region [chemical binding]; other site
373153000037	ATP-binding site [chemical binding]; other site
373153000038	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
373153000039	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
373153000040	RNA binding surface [nucleotide binding]; other site
373153000041	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
373153000042	Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367
373153000043	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
373153000044	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
373153000045	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
373153000046	Ligand Binding Site [chemical binding]; other site
373153000047	TilS substrate C-terminal domain; Region: TilS_C; smart00977
373153000048	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
373153000049	active site
373153000050	ATP-dependent Zn proteases [Posttranslational modification, protein turnover, chaperones]; Region: HflB; COG0465
373153000051	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
373153000052	Walker A motif; other site
373153000053	ATP binding site [chemical binding]; other site
373153000054	Walker B motif; other site
373153000055	arginine finger; other site
373153000056	Peptidase family M41; Region: Peptidase_M41; pfam01434
373153000057	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
373153000058	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
373153000059	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
373153000060	GDP-binding site [chemical binding]; other site
373153000061	ACT binding site; other site
373153000062	IMP binding site; other site
373153000063	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
373153000064	nucleoside/Zn binding site; other site
373153000065	dimer interface [polypeptide binding]; other site
373153000066	catalytic motif [active]
373153000067	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
373153000068	trimer interface [polypeptide binding]; other site
373153000069	active site
373153000070	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
373153000071	catalytic core [active]
373153000072	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
373153000073	DNA repair protein RadA; Provisional; Region: PRK11823
373153000074	Walker A motif; other site
373153000075	ATP binding site [chemical binding]; other site
373153000076	Walker B motif; other site
373153000077	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
373153000078	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeD; cd03379
373153000079	active site clefts [active]
373153000080	zinc binding site [ion binding]; other site
373153000081	dimer interface [polypeptide binding]; other site
373153000082	Membrane proteinase, regulator of anti-sigma factor [Posttranslational modification, protein turnover, chaperones]; Region: prsW; COG2339
373153000083	Protease prsW family; Region: PrsW-protease; cl15823
373153000084	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269
373153000085	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
373153000086	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
373153000087	active site
373153000088	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
373153000089	DNA polymerase I; Provisional; Region: PRK05755
373153000090	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
373153000091	active site
373153000092	metal binding site 1 [ion binding]; metal-binding site
373153000093	putative 5' ssDNA interaction site; other site
373153000094	metal binding site 3; metal-binding site
373153000095	metal binding site 2 [ion binding]; metal-binding site
373153000096	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
373153000097	putative DNA binding site [nucleotide binding]; other site
373153000098	putative metal binding site [ion binding]; other site
373153000099	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
373153000100	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
373153000101	active site
373153000102	DNA binding site [nucleotide binding]
373153000103	catalytic site [active]
373153000104	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
373153000105	Predicted membrane protein [Function unknown]; Region: COG2855
373153000106	aromatic amino acid aminotransferase; Validated; Region: PRK07309
373153000107	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
373153000108	pyridoxal 5'-phosphate binding site [chemical binding]; other site
373153000109	homodimer interface [polypeptide binding]; other site
373153000110	catalytic residue [active]
373153000111	Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381
373153000112	Recombination protein O N terminal; Region: RecO_N; pfam11967
373153000113	Recombination protein O C terminal; Region: RecO_C; pfam02565
373153000114	putative phosphate acyltransferase; Provisional; Region: PRK05331
373153000115	Bacteriocin class II with double-glycine leader peptide; Region: Bacteriocin_IIc; pfam10439
373153000116	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418
373153000117	ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193
373153000118	putative active site [active]
373153000119	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
373153000120	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
373153000121	Walker A/P-loop; other site
373153000122	ATP binding site [chemical binding]; other site
373153000123	Q-loop/lid; other site
373153000124	ABC transporter signature motif; other site
373153000125	Walker B; other site
373153000126	D-loop; other site
373153000127	H-loop/switch region; other site
373153000128	bacteriocin secretion accessory protein; Region: bacteriocin_acc; TIGR01000
373153000129	HlyD family secretion protein; Region: HlyD_3; pfam13437
373153000130	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
373153000131	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
373153000132	ATP binding site [chemical binding]; other site
373153000133	active site
373153000134	substrate binding site [chemical binding]; other site
373153000135	phosphoribosylformylglycinamidine synthase, clade II; Region: FGAM-synthase; TIGR01857
373153000136	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
373153000137	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
373153000138	dimerization interface [polypeptide binding]; other site
373153000139	ATP binding site [chemical binding]; other site
373153000140	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
373153000141	dimerization interface [polypeptide binding]; other site
373153000142	ATP binding site [chemical binding]; other site
373153000143	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
373153000144	putative active site [active]
373153000145	catalytic triad [active]
373153000146	amidophosphoribosyltransferase; Provisional; Region: PRK07272
373153000147	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
373153000148	active site
373153000149	tetramer interface [polypeptide binding]; other site
373153000150	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
373153000151	active site
373153000152	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
373153000153	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
373153000154	dimerization interface [polypeptide binding]; other site
373153000155	putative ATP binding site [chemical binding]; other site
373153000156	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
373153000157	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
373153000158	active site
373153000159	substrate binding site [chemical binding]; other site
373153000160	cosubstrate binding site; other site
373153000161	catalytic site [active]
373153000162	VanZ like family; Region: VanZ; pfam04892
373153000163	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
373153000164	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
373153000165	purine monophosphate binding site [chemical binding]; other site
373153000166	dimer interface [polypeptide binding]; other site
373153000167	putative catalytic residues [active]
373153000168	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
373153000169	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
373153000170	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
373153000171	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
373153000172	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
373153000173	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
373153000174	Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041
373153000175	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
373153000176	ATP-grasp domain; Region: ATP-grasp; pfam02222
373153000177	adenylosuccinate lyase; Provisional; Region: PRK07492
373153000178	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
373153000179	tetramer interface [polypeptide binding]; other site
373153000180	active site
373153000181	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
373153000182	N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525
373153000183	Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564
373153000184	active site
373153000185	Glycosyl hydrolase family 20 (GH20) catalytic domain of dispersin B (DspB), lacto-N-biosidase (LnbB) and related proteins. Dispersin B is a soluble beta-N-acetylglucosamidase found in bacteria that hydrolyzes the beta-1,6-linkages of PGA (poly-beta-(1,6)...; Region: GH20_DspB_LnbB-like; cd06564
373153000186	active site
373153000187	G5 domain; Region: G5; pfam07501
373153000188	G5 domain; Region: G5; pfam07501
373153000189	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
373153000190	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
373153000191	DNA-binding site [nucleotide binding]; DNA binding site
373153000192	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
373153000193	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
373153000194	Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301
373153000195	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
373153000196	active site
373153000197	phosphorylation site [posttranslational modification]
373153000198	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
373153000199	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
373153000200	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
373153000201	active pocket/dimerization site; other site
373153000202	active site
373153000203	phosphorylation site [posttranslational modification]
373153000204	putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815
373153000205	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
373153000206	dimer interface [polypeptide binding]; other site
373153000207	active site
373153000208	AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010
373153000209	putative active site [active]
373153000210	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
373153000211	active site
373153000212	catalytic residues [active]
373153000213	Predicted ring-cleavage extradiol dioxygenase [General function prediction only]; Region: COG2514
373153000214	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_12; cd07255
373153000215	putative metal binding site [ion binding]; other site
373153000216	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
373153000217	active site
373153000218	Uncharacterized protein YrkD from Bacillus subtilis and related domains; this domain superfamily was previously known as part of DUF156; Region: BsYrkD-like_DUF156; cd10155
373153000219	putative homodimer interface [polypeptide binding]; other site
373153000220	putative homotetramer interface [polypeptide binding]; other site
373153000221	putative metal binding site [ion binding]; other site
373153000222	putative homodimer-homodimer interface [polypeptide binding]; other site
373153000223	putative allosteric switch controlling residues; other site
373153000224	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
373153000225	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
373153000226	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
373153000227	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
373153000228	TrkA-N domain; Region: TrkA_N; pfam02254
373153000229	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
373153000230	active site
373153000231	Fibronectin-binding repeat; Region: SSURE; pfam11966
373153000232	Fibronectin-binding repeat; Region: SSURE; pfam11966
373153000233	Fibronectin-binding repeat; Region: SSURE; pfam11966
373153000234	Fibronectin-binding repeat; Region: SSURE; pfam11966
373153000235	Fibronectin-binding repeat; Region: SSURE; pfam11966
373153000236	Fibronectin-binding repeat; Region: SSURE; pfam11966
373153000237	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
373153000238	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
373153000239	active site
373153000240	phosphorylation site [posttranslational modification]
373153000241	intermolecular recognition site; other site
373153000242	dimerization interface [polypeptide binding]; other site
373153000243	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
373153000244	DNA binding site [nucleotide binding]
373153000245	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
373153000246	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
373153000247	dimerization interface [polypeptide binding]; other site
373153000248	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
373153000249	dimer interface [polypeptide binding]; other site
373153000250	phosphorylation site [posttranslational modification]
373153000251	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
373153000252	ATP binding site [chemical binding]; other site
373153000253	Mg2+ binding site [ion binding]; other site
373153000254	G-X-G motif; other site
373153000255	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
373153000256	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
373153000257	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
373153000258	RNA binding surface [nucleotide binding]; other site
373153000259	Helix-turn-helix domain; Region: HTH_28; pfam13518
373153000260	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
373153000261	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
373153000262	dimer interface [polypeptide binding]; other site
373153000263	conserved gate region; other site
373153000264	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
373153000265	ABC-ATPase subunit interface; other site
373153000266	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
373153000267	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
373153000268	dimer interface [polypeptide binding]; other site
373153000269	conserved gate region; other site
373153000270	putative PBP binding loops; other site
373153000271	ABC-ATPase subunit interface; other site
373153000272	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
373153000273	Domain of unknown function (DUF3502); Region: DUF3502; pfam12010
373153000274	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
373153000275	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
373153000276	active site residue [active]
373153000277	Protein of unknown function (DUF3650); Region: DUF3650; pfam12368
373153000278	Domain of unknown function (DUF4299); Region: DUF4299; pfam14132
373153000279	Domain of unknown function (DUF4097); Region: DUF4097; pfam13349
373153000280	Predicted membrane protein [Function unknown]; Region: COG4709
373153000281	Predicted transcriptional regulators [Transcription]; Region: COG1695
373153000282	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
373153000283	Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807
373153000284	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
373153000285	putative substrate translocation pore; other site
373153000286	ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525
373153000287	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
373153000288	Ligand binding site; other site
373153000289	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
373153000290	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
373153000291	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
373153000292	NAD(P) binding site [chemical binding]; other site
373153000293	homodimer interface [polypeptide binding]; other site
373153000294	substrate binding site [chemical binding]; other site
373153000295	active site
373153000296	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
373153000297	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
373153000298	active site
373153000299	motif I; other site
373153000300	motif II; other site
373153000301	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
373153000302	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
373153000303	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
373153000304	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
373153000305	C-terminal ACT domain of the L-serine dehydratase (LSD), iron-sulfur-dependent, beta subunit; Region: ACT_LSD; cd04903
373153000306	putative L-serine binding site [chemical binding]; other site
373153000307	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
373153000308	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
373153000309	Bacteriocin (Lactococcin_972); Region: Lactococcin_972; pfam09683
373153000310	bacteriocin-associated integral membrane (putative immunity) protein; Region: bact_immun_7tm; TIGR01654
373153000311	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
373153000312	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
373153000313	Walker A/P-loop; other site
373153000314	ATP binding site [chemical binding]; other site
373153000315	Q-loop/lid; other site
373153000316	ABC transporter signature motif; other site
373153000317	Walker B; other site
373153000318	D-loop; other site
373153000319	H-loop/switch region; other site
373153000320	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
373153000321	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
373153000322	substrate binding pocket [chemical binding]; other site
373153000323	membrane-bound complex binding site; other site
373153000324	hinge residues; other site
373153000325	argininosuccinate synthase; Provisional; Region: PRK13820
373153000326	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
373153000327	ANP binding site [chemical binding]; other site
373153000328	Substrate Binding Site II [chemical binding]; other site
373153000329	Substrate Binding Site I [chemical binding]; other site
373153000330	argininosuccinate lyase; Provisional; Region: PRK00855
373153000331	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
373153000332	active sites [active]
373153000333	tetramer interface [polypeptide binding]; other site
373153000334	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
373153000335	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
373153000336	non-specific DNA binding site [nucleotide binding]; other site
373153000337	salt bridge; other site
373153000338	sequence-specific DNA binding site [nucleotide binding]; other site
373153000339	Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871
373153000340	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
373153000341	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
373153000342	HlyD family secretion protein; Region: HlyD_3; pfam13437
373153000343	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
373153000344	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
373153000345	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
373153000346	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
373153000347	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
373153000348	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
373153000349	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
373153000350	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
373153000351	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
373153000352	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
373153000353	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
373153000354	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
373153000355	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_29; cd04688
373153000356	nudix motif; other site
373153000357	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
373153000358	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
373153000359	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
373153000360	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
373153000361	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
373153000362	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
373153000363	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
373153000364	hypothetical protein; Provisional; Region: PRK13667
373153000365	class IIb bacteriocin, lactobin A/cerein 7B family; Region: bact_IIb_cerein; TIGR03949
373153000366	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
373153000367	Glycoprotease family; Region: Peptidase_M22; pfam00814
373153000368	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
373153000369	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
373153000370	Coenzyme A binding pocket [chemical binding]; other site
373153000371	UGMP family protein; Validated; Region: PRK09604
373153000372	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
373153000373	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
373153000374	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
373153000375	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
373153000376	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
373153000377	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
373153000378	active site
373153000379	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
373153000380	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
373153000381	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
373153000382	Walker A/P-loop; other site
373153000383	ATP binding site [chemical binding]; other site
373153000384	Q-loop/lid; other site
373153000385	ABC transporter signature motif; other site
373153000386	Walker B; other site
373153000387	D-loop; other site
373153000388	H-loop/switch region; other site
373153000389	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
373153000390	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
373153000391	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
373153000392	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
373153000393	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
373153000394	non-specific DNA binding site [nucleotide binding]; other site
373153000395	salt bridge; other site
373153000396	sequence-specific DNA binding site [nucleotide binding]; other site
373153000397	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
373153000398	CAAX protease self-immunity; Region: Abi; pfam02517
373153000399	CAAX protease self-immunity; Region: Abi; pfam02517
373153000400	H+ Antiporter protein; Region: 2A0121; TIGR00900
373153000401	AzlC protein; Region: AzlC; cl00570
373153000402	Branched-chain amino acid transport protein (AzlD); Region: AzlD; cl00735
373153000403	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
373153000404	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
373153000405	substrate binding pocket [chemical binding]; other site
373153000406	membrane-bound complex binding site; other site
373153000407	hinge residues; other site
373153000408	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
373153000409	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
373153000410	hypothetical protein; Provisional; Region: PRK06446
373153000411	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_4; cd05681
373153000412	metal binding site [ion binding]; metal-binding site
373153000413	dimer interface [polypeptide binding]; other site
373153000414	ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135
373153000415	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
373153000416	Walker A/P-loop; other site
373153000417	ATP binding site [chemical binding]; other site
373153000418	Q-loop/lid; other site
373153000419	ABC transporter signature motif; other site
373153000420	Walker B; other site
373153000421	D-loop; other site
373153000422	H-loop/switch region; other site
373153000423	NIL domain; Region: NIL; pfam09383
373153000424	ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011
373153000425	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605
373153000426	Predicted integral membrane protein [Function unknown]; Region: COG5578
373153000427	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
373153000428	HAMP domain; Region: HAMP; pfam00672
373153000429	Histidine kinase; Region: His_kinase; pfam06580
373153000430	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
373153000431	ATP binding site [chemical binding]; other site
373153000432	Mg2+ binding site [ion binding]; other site
373153000433	G-X-G motif; other site
373153000434	Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain [Signal transduction mechanisms]; Region: COG4753
373153000435	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
373153000436	active site
373153000437	phosphorylation site [posttranslational modification]
373153000438	intermolecular recognition site; other site
373153000439	dimerization interface [polypeptide binding]; other site
373153000440	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
373153000441	flavoprotein NrdI; Provisional; Region: PRK02551
373153000442	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
373153000443	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
373153000444	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
373153000445	LytTr DNA-binding domain; Region: LytTR; smart00850
373153000446	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
373153000447	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
373153000448	ATP binding site [chemical binding]; other site
373153000449	Mg2+ binding site [ion binding]; other site
373153000450	G-X-G motif; other site
373153000451	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
373153000452	ATP binding site [chemical binding]; other site
373153000453	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
373153000454	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
373153000455	homopentamer interface [polypeptide binding]; other site
373153000456	active site
373153000457	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
373153000458	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
373153000459	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
373153000460	dimerization interface [polypeptide binding]; other site
373153000461	active site
373153000462	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
373153000463	Lumazine binding domain; Region: Lum_binding; pfam00677
373153000464	Lumazine binding domain; Region: Lum_binding; pfam00677
373153000465	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
373153000466	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
373153000467	catalytic motif [active]
373153000468	Zn binding site [ion binding]; other site
373153000469	RibD C-terminal domain; Region: RibD_C; cl17279
373153000470	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
373153000471	RuvA N terminal domain; Region: RuvA_N; pfam01330
373153000472	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
373153000473	CAAX protease self-immunity; Region: Abi; pfam02517
373153000474	Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062
373153000475	putative dimer interface [polypeptide binding]; other site
373153000476	catalytic triad [active]
373153000477	Uncharacterized membrane-bound protein conserved in bacteria [Function unknown]; Region: COG4858
373153000478	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
373153000479	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
373153000480	Cl binding site [ion binding]; other site
373153000481	oligomer interface [polypeptide binding]; other site
373153000482	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
373153000483	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
373153000484	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
373153000485	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
373153000486	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
373153000487	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
373153000488	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
373153000489	active site
373153000490	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
373153000491	ArsC family; Region: ArsC; pfam03960
373153000492	putative catalytic residues [active]
373153000493	thiol/disulfide switch; other site
373153000494	hypothetical protein; Provisional; Region: PRK05473
373153000495	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
373153000496	hypothetical protein; Provisional; Region: PRK13678
373153000497	folylpolyglutamate synthase/dihydrofolate synthase; Region: folC; TIGR01499
373153000498	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
373153000499	Bacterial lipoprotein; Region: DUF3642; pfam12182
373153000500	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
373153000501	Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502
373153000502	Putative catalytic domain, repeat 1, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_1; cd09154
373153000503	putative active site [active]
373153000504	catalytic site [active]
373153000505	Putative catalytic domain, repeat 2, of Streptococcus mutans uncharacterized protein SMU_988 and similar proteins; Region: PLDc_SMU_988_like_2; cd09160
373153000506	putative active site [active]
373153000507	catalytic site [active]
373153000508	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
373153000509	ATP cone domain; Region: ATP-cone; pfam03477
373153000510	Class III ribonucleotide reductase; Region: RNR_III; cd01675
373153000511	effector binding site; other site
373153000512	active site
373153000513	Zn binding site [ion binding]; other site
373153000514	glycine loop; other site
373153000515	Predicted acetyltransferase [General function prediction only]; Region: COG3981
373153000516	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
373153000517	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
373153000518	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
373153000519	FeS/SAM binding site; other site
373153000520	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
373153000521	active site
373153000522	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
373153000523	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
373153000524	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
373153000525	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
373153000526	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
373153000527	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
373153000528	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
373153000529	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
373153000530	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
373153000531	putative translocon binding site; other site
373153000532	protein-rRNA interface [nucleotide binding]; other site
373153000533	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
373153000534	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
373153000535	G-X-X-G motif; other site
373153000536	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
373153000537	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
373153000538	23S rRNA interface [nucleotide binding]; other site
373153000539	5S rRNA interface [nucleotide binding]; other site
373153000540	putative antibiotic binding site [chemical binding]; other site
373153000541	L25 interface [polypeptide binding]; other site
373153000542	L27 interface [polypeptide binding]; other site
373153000543	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
373153000544	23S rRNA interface [nucleotide binding]; other site
373153000545	putative translocon interaction site; other site
373153000546	signal recognition particle (SRP54) interaction site; other site
373153000547	L23 interface [polypeptide binding]; other site
373153000548	trigger factor interaction site; other site
373153000549	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
373153000550	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
373153000551	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
373153000552	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
373153000553	RNA binding site [nucleotide binding]; other site
373153000554	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
373153000555	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
373153000556	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
373153000557	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
373153000558	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
373153000559	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
373153000560	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
373153000561	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
373153000562	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
373153000563	5S rRNA interface [nucleotide binding]; other site
373153000564	L27 interface [polypeptide binding]; other site
373153000565	23S rRNA interface [nucleotide binding]; other site
373153000566	L5 interface [polypeptide binding]; other site
373153000567	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
373153000568	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
373153000569	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
373153000570	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
373153000571	23S rRNA binding site [nucleotide binding]; other site
373153000572	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
373153000573	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
373153000574	SecY translocase; Region: SecY; pfam00344
373153000575	adenylate kinase; Reviewed; Region: adk; PRK00279
373153000576	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
373153000577	AMP-binding site [chemical binding]; other site
373153000578	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
373153000579	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
373153000580	rRNA binding site [nucleotide binding]; other site
373153000581	predicted 30S ribosome binding site; other site
373153000582	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
373153000583	30S ribosomal protein S13; Region: bact_S13; TIGR03631
373153000584	30S ribosomal protein S11; Validated; Region: PRK05309
373153000585	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
373153000586	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
373153000587	alphaNTD homodimer interface [polypeptide binding]; other site
373153000588	alphaNTD - beta interaction site [polypeptide binding]; other site
373153000589	alphaNTD - beta' interaction site [polypeptide binding]; other site
373153000590	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
373153000591	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
373153000592	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
373153000593	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
373153000594	catalytic core [active]
373153000595	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
373153000596	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
373153000597	dimer interface [polypeptide binding]; other site
373153000598	conserved gate region; other site
373153000599	putative PBP binding loops; other site
373153000600	ABC-ATPase subunit interface; other site
373153000601	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
373153000602	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
373153000603	dimer interface [polypeptide binding]; other site
373153000604	conserved gate region; other site
373153000605	ABC-ATPase subunit interface; other site
373153000606	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
373153000607	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
373153000608	Walker A/P-loop; other site
373153000609	ATP binding site [chemical binding]; other site
373153000610	Q-loop/lid; other site
373153000611	ABC transporter signature motif; other site
373153000612	Walker B; other site
373153000613	D-loop; other site
373153000614	H-loop/switch region; other site
373153000615	TOBE domain; Region: TOBE_2; pfam08402
373153000616	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
373153000617	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
373153000618	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
373153000619	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
373153000620	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
373153000621	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
373153000622	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
373153000623	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
373153000624	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
373153000625	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
373153000626	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
373153000627	active site
373153000628	methionine cluster; other site
373153000629	phosphorylation site [posttranslational modification]
373153000630	metal binding site [ion binding]; metal-binding site
373153000631	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
373153000632	active site
373153000633	P-loop; other site
373153000634	phosphorylation site [posttranslational modification]
373153000635	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
373153000636	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
373153000637	Pyruvate-formate lyase [Energy production and conversion]; Region: PflD; COG1882
373153000638	Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677
373153000639	dimer interface [polypeptide binding]; other site
373153000640	active site
373153000641	glycine loop; other site
373153000642	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
373153000643	active site
373153000644	intersubunit interactions; other site
373153000645	catalytic residue [active]
373153000646	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
373153000647	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
373153000648	dimer interface [polypeptide binding]; other site
373153000649	active site
373153000650	metal binding site [ion binding]; metal-binding site
373153000651	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
373153000652	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
373153000653	HIGH motif; other site
373153000654	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
373153000655	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
373153000656	active site
373153000657	KMSKS motif; other site
373153000658	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
373153000659	tRNA binding surface [nucleotide binding]; other site
373153000660	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
373153000661	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
373153000662	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
373153000663	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
373153000664	Coenzyme A binding pocket [chemical binding]; other site
373153000665	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
373153000666	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
373153000667	Walker A motif; other site
373153000668	ATP binding site [chemical binding]; other site
373153000669	Walker B motif; other site
373153000670	arginine finger; other site
373153000671	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
373153000672	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3575
373153000673	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
373153000674	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
373153000675	catalytic residue [active]
373153000676	putative FPP diphosphate  binding site; other site
373153000677	putative FPP binding hydrophobic cleft; other site
373153000678	dimer interface [polypeptide binding]; other site
373153000679	putative IPP diphosphate binding site; other site
373153000680	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
373153000681	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
373153000682	RIP metalloprotease RseP; Region: TIGR00054
373153000683	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
373153000684	active site
373153000685	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
373153000686	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
373153000687	putative substrate binding region [chemical binding]; other site
373153000688	prolyl-tRNA synthetase; Provisional; Region: PRK09194
373153000689	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
373153000690	dimer interface [polypeptide binding]; other site
373153000691	motif 1; other site
373153000692	active site
373153000693	motif 2; other site
373153000694	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
373153000695	putative deacylase active site [active]
373153000696	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
373153000697	active site
373153000698	motif 3; other site
373153000699	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
373153000700	anticodon binding site; other site
373153000701	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
373153000702	beta-galactosidase; Region: BGL; TIGR03356
373153000703	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
373153000704	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
373153000705	glutaminase active site [active]
373153000706	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
373153000707	dimer interface [polypeptide binding]; other site
373153000708	active site
373153000709	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
373153000710	dimer interface [polypeptide binding]; other site
373153000711	active site
373153000712	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
373153000713	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
373153000714	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
373153000715	pullulanase, extracellular, Gram-positive; Region: pullulan_Gpos; TIGR02102
373153000716	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
373153000717	carbohydrate binding site [chemical binding]; other site
373153000718	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
373153000719	carbohydrate binding site [chemical binding]; other site
373153000720	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
373153000721	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
373153000722	Ca binding site [ion binding]; other site
373153000723	active site
373153000724	catalytic site [active]
373153000725	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
373153000726	S17 interaction site [polypeptide binding]; other site
373153000727	S8 interaction site; other site
373153000728	16S rRNA interaction site [nucleotide binding]; other site
373153000729	streptomycin interaction site [chemical binding]; other site
373153000730	23S rRNA interaction site [nucleotide binding]; other site
373153000731	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
373153000732	30S ribosomal protein S7; Validated; Region: PRK05302
373153000733	elongation factor G; Reviewed; Region: PRK00007
373153000734	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
373153000735	G1 box; other site
373153000736	putative GEF interaction site [polypeptide binding]; other site
373153000737	GTP/Mg2+ binding site [chemical binding]; other site
373153000738	Switch I region; other site
373153000739	G2 box; other site
373153000740	G3 box; other site
373153000741	Switch II region; other site
373153000742	G4 box; other site
373153000743	G5 box; other site
373153000744	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
373153000745	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
373153000746	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
373153000747	DNA polymerase III PolC; Validated; Region: polC; PRK00448
373153000748	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
373153000749	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
373153000750	generic binding surface II; other site
373153000751	generic binding surface I; other site
373153000752	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
373153000753	active site
373153000754	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
373153000755	active site
373153000756	catalytic site [active]
373153000757	substrate binding site [chemical binding]; other site
373153000758	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
373153000759	putative PHP Thumb interface [polypeptide binding]; other site
373153000760	active site
373153000761	addiction module antitoxin, RelB/DinJ family; Region: RelB_DinJ; TIGR02384
373153000762	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041
373153000763	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
373153000764	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
373153000765	Predicted membrane protein [Function unknown]; Region: COG2261
373153000766	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
373153000767	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
373153000768	RNA binding surface [nucleotide binding]; other site
373153000769	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
373153000770	active site
373153000771	uracil binding [chemical binding]; other site
373153000772	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
373153000773	trimer interface [polypeptide binding]; other site
373153000774	active site
373153000775	G bulge; other site
373153000776	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
373153000777	PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065
373153000778	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
373153000779	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
373153000780	active pocket/dimerization site; other site
373153000781	active site
373153000782	phosphorylation site [posttranslational modification]
373153000783	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
373153000784	active site
373153000785	phosphorylation site [posttranslational modification]
373153000786	ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422
373153000787	Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297
373153000788	NAD binding site [chemical binding]; other site
373153000789	substrate binding site [chemical binding]; other site
373153000790	catalytic Zn binding site [ion binding]; other site
373153000791	tetramer interface [polypeptide binding]; other site
373153000792	structural Zn binding site [ion binding]; other site
373153000793	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
373153000794	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
373153000795	active site
373153000796	motif I; other site
373153000797	motif II; other site
373153000798	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
373153000799	Predicted metal-dependent membrane protease [General function prediction only]; Region: COG1266
373153000800	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
373153000801	dihydropteroate synthase; Region: DHPS; TIGR01496
373153000802	substrate binding pocket [chemical binding]; other site
373153000803	dimer interface [polypeptide binding]; other site
373153000804	inhibitor binding site; inhibition site
373153000805	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
373153000806	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
373153000807	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
373153000808	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
373153000809	homodecamer interface [polypeptide binding]; other site
373153000810	GTP cyclohydrolase I; Provisional; Region: PLN03044
373153000811	active site
373153000812	putative catalytic site residues [active]
373153000813	zinc binding site [ion binding]; other site
373153000814	GTP-CH-I/GFRP interaction surface; other site
373153000815	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
373153000816	homooctamer interface [polypeptide binding]; other site
373153000817	active site
373153000818	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
373153000819	catalytic center binding site [active]
373153000820	ATP binding site [chemical binding]; other site
373153000821	Staphylococcal protein of unknown function (DUF960); Region: DUF960; pfam06124
373153000822	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
373153000823	23S rRNA interface [nucleotide binding]; other site
373153000824	L3 interface [polypeptide binding]; other site
373153000825	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
373153000826	Uncharacterized conserved protein [Function unknown]; Region: COG1359
373153000827	6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589
373153000828	beta-galactosidase; Region: BGL; TIGR03356
373153000829	Uncharacterized conserved protein [Function unknown]; Region: COG4095
373153000830	cellobiose phosphotransferase system IIB component; Reviewed; Region: celB; PRK09590
373153000831	active site
373153000832	P-loop; other site
373153000833	phosphorylation site [posttranslational modification]
373153000834	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
373153000835	HTH domain; Region: HTH_11; pfam08279
373153000836	Mga helix-turn-helix domain; Region: Mga; pfam05043
373153000837	PRD domain; Region: PRD; pfam00874
373153000838	PRD domain; Region: PRD; pfam00874
373153000839	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
373153000840	active site
373153000841	P-loop; other site
373153000842	phosphorylation site [posttranslational modification]
373153000843	Phosphotransferase system mannitol/fructose-specific IIA domain (Ntr-type) [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: PtsN; COG1762
373153000844	active site
373153000845	phosphorylation site [posttranslational modification]
373153000846	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
373153000847	methionine cluster; other site
373153000848	active site
373153000849	phosphorylation site [posttranslational modification]
373153000850	metal binding site [ion binding]; metal-binding site
373153000851	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
373153000852	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
373153000853	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
373153000854	This family represents an uncharacterized glycosyl hydrolase family 31 (GH31) enzyme found in bacteria and eukaryotes that is related to the XylS xylosidase of Sulfolobus solfataricus. Alpha-xylosidases catalyze the release of an alpha-xylose residue...; Region: GH31_xylosidase_XylS-like; cd06595
373153000855	putative active site [active]
373153000856	putative catalytic site [active]
373153000857	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
373153000858	catalytic residues [active]
373153000859	dimer interface [polypeptide binding]; other site
373153000860	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
373153000861	Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083
373153000862	substrate binding site [chemical binding]; other site
373153000863	catalytic residues [active]
373153000864	2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800
373153000865	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
373153000866	active site
373153000867	intersubunit interface [polypeptide binding]; other site
373153000868	catalytic residue [active]
373153000869	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
373153000870	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
373153000871	substrate binding site [chemical binding]; other site
373153000872	ATP binding site [chemical binding]; other site
373153000873	hypothetical protein; Provisional; Region: PRK09273
373153000874	Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698
373153000875	Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408
373153000876	gluconate 5-dehydrogenase; Provisional; Region: PRK07097
373153000877	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
373153000878	NADP binding site [chemical binding]; other site
373153000879	homodimer interface [polypeptide binding]; other site
373153000880	active site
373153000881	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
373153000882	active pocket/dimerization site; other site
373153000883	active site
373153000884	phosphorylation site [posttranslational modification]
373153000885	Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470
373153000886	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
373153000887	active site
373153000888	phosphorylation site [posttranslational modification]
373153000889	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
373153000890	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
373153000891	Preprotein translocase subunit YajC [Intracellular trafficking and secretion]; Region: YajC; COG1862
373153000892	Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940
373153000893	Transcriptional regulators [Transcription]; Region: PurR; COG1609
373153000894	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
373153000895	DNA binding site [nucleotide binding]
373153000896	domain linker motif; other site
373153000897	Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283
373153000898	putative dimerization interface [polypeptide binding]; other site
373153000899	putative ligand binding site [chemical binding]; other site
373153000900	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
373153000901	non-specific DNA binding site [nucleotide binding]; other site
373153000902	salt bridge; other site
373153000903	sequence-specific DNA binding site [nucleotide binding]; other site
373153000904	Predicted S-adenosylmethionine-dependent methyltransferase involved in cell envelope biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG0275
373153000905	MraW methylase family; Region: Methyltransf_5; pfam01795
373153000906	Protein required for the initiation of cell division [Cell division and chromosome partitioning]; Region: FtsL; COG4839
373153000907	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
373153000908	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
373153000909	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
373153000910	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573
373153000911	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cd06573
373153000912	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
373153000913	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
373153000914	Mg++ binding site [ion binding]; other site
373153000915	putative catalytic motif [active]
373153000916	putative substrate binding site [chemical binding]; other site
373153000917	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
373153000918	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
373153000919	Walker A motif; other site
373153000920	ATP binding site [chemical binding]; other site
373153000921	Walker B motif; other site
373153000922	arginine finger; other site
373153000923	UvrB/uvrC motif; Region: UVR; pfam02151
373153000924	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
373153000925	Walker A motif; other site
373153000926	ATP binding site [chemical binding]; other site
373153000927	Walker B motif; other site
373153000928	arginine finger; other site
373153000929	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
373153000930	LuxS protein involved in autoinducer AI2 synthesis [Signal transduction mechanisms]; Region: LuxS; COG1854
373153000931	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4868
373153000932	hypothetical protein; Provisional; Region: PRK13663
373153000933	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
373153000934	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
373153000935	Ca binding site [ion binding]; other site
373153000936	active site
373153000937	catalytic site [active]
373153000938	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261
373153000939	DNA polymerase processivity factor; Region: DNA_PPF; pfam02916
373153000940	Transcriptional regulator [Transcription]; Region: LytR; COG1316
373153000941	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
373153000942	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
373153000943	polysaccharide export protein, MPA1 family, Gram-positive type; Region: polys_exp_MPA1; TIGR01006
373153000944	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
373153000945	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
373153000946	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
373153000947	Bacterial sugar transferase; Region: Bac_transf; pfam02397
373153000948	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_6; cd04955
373153000949	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
373153000950	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
373153000951	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_d; cd04196
373153000952	Probable Catalytic site; other site
373153000953	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
373153000954	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
373153000955	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
373153000956	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
373153000957	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
373153000958	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
373153000959	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
373153000960	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
373153000961	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
373153000962	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
373153000963	UDP-galactopyranose mutase; Region: GLF; pfam03275
373153000964	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
373153000965	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
373153000966	substrate binding site; other site
373153000967	tetramer interface; other site
373153000968	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
373153000969	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
373153000970	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
373153000971	NAD binding site [chemical binding]; other site
373153000972	substrate binding site [chemical binding]; other site
373153000973	homodimer interface [polypeptide binding]; other site
373153000974	active site
373153000975	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
373153000976	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
373153000977	NADP binding site [chemical binding]; other site
373153000978	active site
373153000979	putative substrate binding site [chemical binding]; other site
373153000980	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
373153000981	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
373153000982	peptide binding site [polypeptide binding]; other site
373153000983	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
373153000984	Endo-alpha-N-acetylgalactosaminidase; Region: Glyco_hydro_101; pfam12905
373153000985	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
373153000986	Transglycosylase; Region: Transgly; pfam00912
373153000987	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
373153000988	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
373153000989	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
373153000990	hypothetical protein; Provisional; Region: PRK13660
373153000991	cell division protein GpsB; Provisional; Region: PRK14127
373153000992	DivIVA domain; Region: DivI1A_domain; TIGR03544
373153000993	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
373153000994	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
373153000995	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
373153000996	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
373153000997	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
373153000998	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
373153000999	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
373153001000	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
373153001001	active site
373153001002	phosphorylation site [posttranslational modification]
373153001003	intermolecular recognition site; other site
373153001004	dimerization interface [polypeptide binding]; other site
373153001005	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
373153001006	DNA binding site [nucleotide binding]
373153001007	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
373153001008	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
373153001009	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
373153001010	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
373153001011	Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407
373153001012	diphosphomevalonate decarboxylase; Region: PLN02407
373153001013	Mevalonate kinase [Lipid metabolism]; Region: ERG12; COG1577
373153001014	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
373153001015	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
373153001016	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
373153001017	homotetramer interface [polypeptide binding]; other site
373153001018	FMN binding site [chemical binding]; other site
373153001019	homodimer contacts [polypeptide binding]; other site
373153001020	putative active site [active]
373153001021	putative substrate binding site [chemical binding]; other site
373153001022	Predicted membrane protein [Function unknown]; Region: COG4758
373153001023	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
373153001024	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
373153001025	Histidine kinase; Region: HisKA_3; pfam07730
373153001026	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
373153001027	ATP binding site [chemical binding]; other site
373153001028	Mg2+ binding site [ion binding]; other site
373153001029	G-X-G motif; other site
373153001030	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
373153001031	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
373153001032	active site
373153001033	phosphorylation site [posttranslational modification]
373153001034	intermolecular recognition site; other site
373153001035	dimerization interface [polypeptide binding]; other site
373153001036	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
373153001037	DNA binding residues [nucleotide binding]
373153001038	dimerization interface [polypeptide binding]; other site
373153001039	A new structural DNA glycosylase; Region: AlkD_like; cl11434
373153001040	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
373153001041	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
373153001042	Helix-turn-helix domain; Region: HTH_28; pfam13518
373153001043	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
373153001044	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
373153001045	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
373153001046	active site
373153001047	P-loop; other site
373153001048	phosphorylation site [posttranslational modification]
373153001049	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
373153001050	active site
373153001051	P-loop; other site
373153001052	phosphorylation site [posttranslational modification]
373153001053	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
373153001054	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
373153001055	active site
373153001056	P-loop; other site
373153001057	phosphorylation site [posttranslational modification]
373153001058	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
373153001059	active site
373153001060	phosphorylation site [posttranslational modification]
373153001061	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
373153001062	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
373153001063	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
373153001064	putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264
373153001065	trigger factor; Provisional; Region: tig; PRK01490
373153001066	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
373153001067	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
373153001068	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
373153001069	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
373153001070	DNA binding site [nucleotide binding]
373153001071	AAA domain; Region: AAA_30; pfam13604
373153001072	Family description; Region: UvrD_C_2; pfam13538
373153001073	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
373153001074	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
373153001075	Catalytic site [active]
373153001076	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
373153001077	ribonuclease HIII; Provisional; Region: PRK00996
373153001078	Domain of unknown function (DUF3378); Region: DUF3378; pfam11858
373153001079	bacterial Ribonuclease HIII-like; Region: RNase_HII_bacteria_HIII_like; cd06590
373153001080	RNA/DNA hybrid binding site [nucleotide binding]; other site
373153001081	active site
373153001082	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
373153001083	Colicin V production protein; Region: Colicin_V; pfam02674
373153001084	Mismatch repair ATPase (MutS family) [DNA replication, recombination, and repair]; Region: COG1193
373153001085	MutS domain III; Region: MutS_III; pfam05192
373153001086	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
373153001087	Walker A/P-loop; other site
373153001088	ATP binding site [chemical binding]; other site
373153001089	Q-loop/lid; other site
373153001090	ABC transporter signature motif; other site
373153001091	Walker B; other site
373153001092	D-loop; other site
373153001093	H-loop/switch region; other site
373153001094	Smr domain; Region: Smr; pfam01713
373153001095	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
373153001096	amino acid carrier protein; Region: agcS; TIGR00835
373153001097	Uncharacterized conserved protein [Function unknown]; Region: COG2128
373153001098	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
373153001099	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
373153001100	C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325
373153001101	gating phenylalanine in ion channel; other site
373153001102	seryl-tRNA synthetase; Provisional; Region: PRK05431
373153001103	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
373153001104	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
373153001105	dimer interface [polypeptide binding]; other site
373153001106	active site
373153001107	motif 1; other site
373153001108	motif 2; other site
373153001109	motif 3; other site
373153001110	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4687
373153001111	aspartate kinase; Reviewed; Region: PRK09034
373153001112	AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245
373153001113	putative catalytic residues [active]
373153001114	putative nucleotide binding site [chemical binding]; other site
373153001115	putative aspartate binding site [chemical binding]; other site
373153001116	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
373153001117	allosteric regulatory residue; other site
373153001118	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
373153001119	enoyl-CoA hydratase; Provisional; Region: PRK07260
373153001120	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
373153001121	substrate binding site [chemical binding]; other site
373153001122	oxyanion hole (OAH) forming residues; other site
373153001123	trimer interface [polypeptide binding]; other site
373153001124	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
373153001125	MarR family; Region: MarR_2; pfam12802
373153001126	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
373153001127	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
373153001128	dimer interface [polypeptide binding]; other site
373153001129	active site
373153001130	CoA binding pocket [chemical binding]; other site
373153001131	acyl carrier protein; Provisional; Region: acpP; PRK00982
373153001132	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
373153001133	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
373153001134	FMN binding site [chemical binding]; other site
373153001135	substrate binding site [chemical binding]; other site
373153001136	putative catalytic residue [active]
373153001137	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
373153001138	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
373153001139	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
373153001140	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
373153001141	NAD(P) binding site [chemical binding]; other site
373153001142	homotetramer interface [polypeptide binding]; other site
373153001143	homodimer interface [polypeptide binding]; other site
373153001144	active site
373153001145	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
373153001146	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
373153001147	dimer interface [polypeptide binding]; other site
373153001148	active site
373153001149	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
373153001150	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
373153001151	carboxyltransferase (CT) interaction site; other site
373153001152	biotinylation site [posttranslational modification]; other site
373153001153	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
373153001154	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
373153001155	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
373153001156	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
373153001157	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
373153001158	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
373153001159	Uncharacterized protein family UPF0547; Region: UPF0547; pfam10571
373153001160	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
373153001161	acetyl-CoA carboxylase subunit alpha; Provisional; Region: PRK12319
373153001162	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
373153001163	putative RNA binding site [nucleotide binding]; other site
373153001164	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
373153001165	elongation factor P; Validated; Region: PRK00529
373153001166	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
373153001167	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
373153001168	RNA binding site [nucleotide binding]; other site
373153001169	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
373153001170	RNA binding site [nucleotide binding]; other site
373153001171	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
373153001172	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
373153001173	GatB domain; Region: GatB_Yqey; pfam02637
373153001174	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
373153001175	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
373153001176	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
373153001177	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
373153001178	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
373153001179	G1 box; other site
373153001180	putative GEF interaction site [polypeptide binding]; other site
373153001181	GTP/Mg2+ binding site [chemical binding]; other site
373153001182	Switch I region; other site
373153001183	G2 box; other site
373153001184	G3 box; other site
373153001185	Switch II region; other site
373153001186	G4 box; other site
373153001187	G5 box; other site
373153001188	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
373153001189	Lipopolysaccharide biosynthesis proteins, LPS:glycosyltransferases [Cell envelope biogenesis, outer membrane]; Region: RfaJ; COG1442
373153001190	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
373153001191	Ligand binding site; other site
373153001192	metal-binding site
373153001193	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
373153001194	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
373153001195	Predicted kinase related to dihydroxyacetone kinase [General function prediction only]; Region: COG1461
373153001196	DAK2 domain; Region: Dak2; pfam02734
373153001197	acetolactate synthase catalytic subunit; Reviewed; Region: PRK07282
373153001198	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
373153001199	PYR/PP interface [polypeptide binding]; other site
373153001200	dimer interface [polypeptide binding]; other site
373153001201	TPP binding site [chemical binding]; other site
373153001202	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
373153001203	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
373153001204	TPP-binding site [chemical binding]; other site
373153001205	dimer interface [polypeptide binding]; other site
373153001206	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
373153001207	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
373153001208	putative valine binding site [chemical binding]; other site
373153001209	dimer interface [polypeptide binding]; other site
373153001210	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
373153001211	ketol-acid reductoisomerase; Provisional; Region: PRK05479
373153001212	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
373153001213	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
373153001214	threonine dehydratase; Validated; Region: PRK08639
373153001215	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
373153001216	tetramer interface [polypeptide binding]; other site
373153001217	pyridoxal 5'-phosphate binding site [chemical binding]; other site
373153001218	catalytic residue [active]
373153001219	C-terminal regulatory domain of Threonine dehydratase; Region: Thr_dehydrat_C; pfam00585
373153001220	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
373153001221	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
373153001222	Walker A/P-loop; other site
373153001223	ATP binding site [chemical binding]; other site
373153001224	Q-loop/lid; other site
373153001225	ABC transporter signature motif; other site
373153001226	Walker B; other site
373153001227	D-loop; other site
373153001228	H-loop/switch region; other site
373153001229	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
373153001230	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
373153001231	substrate binding pocket [chemical binding]; other site
373153001232	membrane-bound complex binding site; other site
373153001233	hinge residues; other site
373153001234	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
373153001235	dimer interface [polypeptide binding]; other site
373153001236	conserved gate region; other site
373153001237	putative PBP binding loops; other site
373153001238	ABC-ATPase subunit interface; other site
373153001239	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
373153001240	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281
373153001241	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
373153001242	active site
373153001243	DNA polymerase IV; Validated; Region: PRK02406
373153001244	DNA binding site [nucleotide binding]
373153001245	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
373153001246	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
373153001247	Transcriptional regulators [Transcription]; Region: MarR; COG1846
373153001248	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
373153001249	non-specific DNA interactions [nucleotide binding]; other site
373153001250	DNA binding site [nucleotide binding]
373153001251	sequence specific DNA binding site [nucleotide binding]; other site
373153001252	putative cAMP binding site [chemical binding]; other site
373153001253	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
373153001254	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
373153001255	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
373153001256	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
373153001257	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
373153001258	methionine cluster; other site
373153001259	active site
373153001260	phosphorylation site [posttranslational modification]
373153001261	metal binding site [ion binding]; metal-binding site
373153001262	6-phospho-beta-galactosidase; Provisional; Region: PRK13511
373153001263	beta-galactosidase; Region: BGL; TIGR03356
373153001264	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
373153001265	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
373153001266	PTS_IIB_lactose: subunit IIB of enzyme II (EII) of the lactose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS) found in Firmicutes as well as Actinobacteria. In this system, EII is a lactose-specific permease with two...; Region: PTS_IIB_lactose; cd05565
373153001267	active site
373153001268	P-loop; other site
373153001269	phosphorylation site [posttranslational modification]
373153001270	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
373153001271	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
373153001272	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
373153001273	TrkA-N domain; Region: TrkA_N; pfam02254
373153001274	TrkA-C domain; Region: TrkA_C; pfam02080
373153001275	TrkA-N domain; Region: TrkA_N; pfam02254
373153001276	TrkA-C domain; Region: TrkA_C; pfam02080
373153001277	Uncharacterized conserved protein [Function unknown]; Region: COG1912
373153001278	hypothetical protein; Provisional; Region: PRK13661
373153001279	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
373153001280	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
373153001281	Walker A/P-loop; other site
373153001282	ATP binding site [chemical binding]; other site
373153001283	Q-loop/lid; other site
373153001284	ABC transporter signature motif; other site
373153001285	Walker B; other site
373153001286	D-loop; other site
373153001287	H-loop/switch region; other site
373153001288	ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558
373153001289	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
373153001290	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
373153001291	Walker A/P-loop; other site
373153001292	ATP binding site [chemical binding]; other site
373153001293	Q-loop/lid; other site
373153001294	ABC transporter signature motif; other site
373153001295	Walker B; other site
373153001296	D-loop; other site
373153001297	H-loop/switch region; other site
373153001298	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
373153001299	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
373153001300	Predicted membrane protein [Function unknown]; Region: COG3601
373153001301	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
373153001302	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
373153001303	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
373153001304	active site
373153001305	ParB-like nuclease domain; Region: ParBc; cl02129
373153001306	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
373153001307	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
373153001308	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066
373153001309	CTP synthetase; Validated; Region: pyrG; PRK05380
373153001310	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
373153001311	Catalytic site [active]
373153001312	active site
373153001313	UTP binding site [chemical binding]; other site
373153001314	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
373153001315	active site
373153001316	putative oxyanion hole; other site
373153001317	catalytic triad [active]
373153001318	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
373153001319	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
373153001320	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
373153001321	PhoU domain; Region: PhoU; pfam01895
373153001322	PhoU domain; Region: PhoU; pfam01895
373153001323	Endo-beta-N-acetylglucosaminidase D [Carbohydrate transport and metabolism]; Region: COG4724
373153001324	Endo-beta-N-acetylglucosaminidase (ENGase) hydrolyzes the N-N'-diacetylchitobiosyl core of N-glycosylproteins.  The beta-1,4-glycosyl bond located between two N-acetylglucosamine residues is hydrolyzed such that N-acetylglucosamine 1 remains with...; Region: GH85_ENGase; cd06547
373153001325	putative active site [active]
373153001326	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
373153001327	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
373153001328	Bacterial Ig-like domain (group 3); Region: Big_3; pfam07523
373153001329	G5 domain; Region: G5; pfam07501
373153001330	phosphoglycerate kinase; Provisional; Region: pgk; PRK00073
373153001331	Phosphoglycerate kinase; Region: PGK; pfam00162
373153001332	substrate binding site [chemical binding]; other site
373153001333	hinge regions; other site
373153001334	ADP binding site [chemical binding]; other site
373153001335	catalytic site [active]
373153001336	Predicted membrane protein [Function unknown]; Region: COG4129
373153001337	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
373153001338	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
373153001339	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
373153001340	DNA binding residues [nucleotide binding]
373153001341	putative dimer interface [polypeptide binding]; other site
373153001342	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
373153001343	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
373153001344	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
373153001345	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
373153001346	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
373153001347	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
373153001348	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
373153001349	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
373153001350	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
373153001351	VanD integrase, IntD, and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, N- and C-terminal domains. This CD includes various bacterial integrases including those similar to IntD, a putative integrase-like protein, a component...; Region: INT_VanD; cd01196
373153001352	Int/Topo IB signature motif; other site
373153001353	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
373153001354	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
373153001355	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
373153001356	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
373153001357	HsdM N-terminal domain; Region: HsdM_N; pfam12161
373153001358	Methyltransferase domain; Region: Methyltransf_26; pfam13659
373153001359	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
373153001360	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
373153001361	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
373153001362	ATP binding site [chemical binding]; other site
373153001363	putative Mg++ binding site [ion binding]; other site
373153001364	Protein of unknown function (DUF2812); Region: DUF2812; pfam11193
373153001365	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
373153001366	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
373153001367	Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576
373153001368	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
373153001369	dimer interface [polypeptide binding]; other site
373153001370	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
373153001371	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
373153001372	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
373153001373	nucleotide binding site [chemical binding]; other site
373153001374	NEF interaction site [polypeptide binding]; other site
373153001375	SBD interface [polypeptide binding]; other site
373153001376	chaperone protein DnaJ; Provisional; Region: PRK14276
373153001377	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
373153001378	HSP70 interaction site [polypeptide binding]; other site
373153001379	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
373153001380	substrate binding site [polypeptide binding]; other site
373153001381	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
373153001382	Zn binding sites [ion binding]; other site
373153001383	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
373153001384	substrate binding site [polypeptide binding]; other site
373153001385	dimer interface [polypeptide binding]; other site
373153001386	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
373153001387	HIT family signature motif; other site
373153001388	catalytic residue [active]
373153001389	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
373153001390	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
373153001391	Walker A/P-loop; other site
373153001392	ATP binding site [chemical binding]; other site
373153001393	Q-loop/lid; other site
373153001394	ABC transporter signature motif; other site
373153001395	Walker B; other site
373153001396	D-loop; other site
373153001397	H-loop/switch region; other site
373153001398	Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542
373153001399	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
373153001400	LytTr DNA-binding domain; Region: LytTR; pfam04397
373153001401	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
373153001402	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
373153001403	active site
373153001404	phosphorylation site [posttranslational modification]
373153001405	intermolecular recognition site; other site
373153001406	dimerization interface [polypeptide binding]; other site
373153001407	LytTr DNA-binding domain; Region: LytTR; pfam04397
373153001408	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
373153001409	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
373153001410	ATP binding site [chemical binding]; other site
373153001411	Mg2+ binding site [ion binding]; other site
373153001412	G-X-G motif; other site
373153001413	COMC family; Region: ComC; pfam03047
373153001414	CAAX protease self-immunity; Region: Abi; pfam02517
373153001415	CAAX protease self-immunity; Region: Abi; pfam02517
373153001416	Phosphotransferase enzyme family; Region: APH; pfam01636
373153001417	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
373153001418	substrate binding site [chemical binding]; other site
373153001419	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
373153001420	S-adenosylmethionine binding site [chemical binding]; other site
373153001421	ribosome maturation protein RimP; Reviewed; Region: PRK00092
373153001422	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
373153001423	putative oligomer interface [polypeptide binding]; other site
373153001424	putative RNA binding site [nucleotide binding]; other site
373153001425	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
373153001426	NusA N-terminal domain; Region: NusA_N; pfam08529
373153001427	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
373153001428	RNA binding site [nucleotide binding]; other site
373153001429	homodimer interface [polypeptide binding]; other site
373153001430	NusA-like KH domain; Region: KH_5; pfam13184
373153001431	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
373153001432	G-X-X-G motif; other site
373153001433	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
373153001434	putative RNA binding cleft [nucleotide binding]; other site
373153001435	hypothetical protein; Provisional; Region: PRK07283
373153001436	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
373153001437	translation initiation factor IF-2; Region: IF-2; TIGR00487
373153001438	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
373153001439	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
373153001440	G1 box; other site
373153001441	putative GEF interaction site [polypeptide binding]; other site
373153001442	GTP/Mg2+ binding site [chemical binding]; other site
373153001443	Switch I region; other site
373153001444	G2 box; other site
373153001445	G3 box; other site
373153001446	Switch II region; other site
373153001447	G4 box; other site
373153001448	G5 box; other site
373153001449	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
373153001450	Translation-initiation factor 2; Region: IF-2; pfam11987
373153001451	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
373153001452	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
373153001453	Domain of unknown function (DUF1858); Region: DUF1858; pfam08984
373153001454	Uncharacterized conserved protein [Function unknown]; Region: COG2461
373153001455	Family of unknown function (DUF438); Region: DUF438; pfam04282
373153001456	Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814
373153001457	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
373153001458	putative active site [active]
373153001459	heme pocket [chemical binding]; other site
373153001460	Domain of unknown function (DUF1912); Region: DUF1912; pfam08930
373153001461	hypothetical protein; Provisional; Region: PRK07758
373153001462	Flavin Reductases; Region: FlaRed; cl00801
373153001463	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
373153001464	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
373153001465	Coenzyme A binding pocket [chemical binding]; other site
373153001466	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
373153001467	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
373153001468	active site
373153001469	HIGH motif; other site
373153001470	nucleotide binding site [chemical binding]; other site
373153001471	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
373153001472	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
373153001473	active site
373153001474	KMSKS motif; other site
373153001475	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
373153001476	tRNA binding surface [nucleotide binding]; other site
373153001477	anticodon binding site; other site
373153001478	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
373153001479	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
373153001480	Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184
373153001481	Fic/DOC family; Region: Fic; pfam02661
373153001482	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
373153001483	Helix-turn-helix domain; Region: HTH_28; pfam13518
373153001484	transcriptional antiterminator BglG; Provisional; Region: PRK09772
373153001485	CAT RNA binding domain; Region: CAT_RBD; smart01061
373153001486	PRD domain; Region: PRD; pfam00874
373153001487	PRD domain; Region: PRD; pfam00874
373153001488	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
373153001489	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
373153001490	active site turn [active]
373153001491	phosphorylation site [posttranslational modification]
373153001492	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
373153001493	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
373153001494	HPr interaction site; other site
373153001495	glycerol kinase (GK) interaction site [polypeptide binding]; other site
373153001496	active site
373153001497	phosphorylation site [posttranslational modification]
373153001498	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
373153001499	beta-galactosidase; Region: BGL; TIGR03356
373153001500	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
373153001501	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
373153001502	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
373153001503	dimer interface [polypeptide binding]; other site
373153001504	motif 1; other site
373153001505	active site
373153001506	motif 2; other site
373153001507	motif 3; other site
373153001508	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
373153001509	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
373153001510	Coenzyme A binding pocket [chemical binding]; other site
373153001511	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
373153001512	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
373153001513	putative tRNA-binding site [nucleotide binding]; other site
373153001514	B3/4 domain; Region: B3_4; pfam03483
373153001515	tRNA synthetase B5 domain; Region: B5; smart00874
373153001516	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
373153001517	dimer interface [polypeptide binding]; other site
373153001518	motif 1; other site
373153001519	motif 3; other site
373153001520	motif 2; other site
373153001521	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
373153001522	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
373153001523	putative catalytic site [active]
373153001524	putative metal binding site [ion binding]; other site
373153001525	putative phosphate binding site [ion binding]; other site
373153001526	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
373153001527	non-specific DNA binding site [nucleotide binding]; other site
373153001528	salt bridge; other site
373153001529	sequence-specific DNA binding site [nucleotide binding]; other site
373153001530	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
373153001531	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
373153001532	THF binding site; other site
373153001533	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
373153001534	substrate binding site [chemical binding]; other site
373153001535	THF binding site; other site
373153001536	zinc-binding site [ion binding]; other site
373153001537	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
373153001538	FAD binding site [chemical binding]; other site
373153001539	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
373153001540	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
373153001541	RNase E interface [polypeptide binding]; other site
373153001542	trimer interface [polypeptide binding]; other site
373153001543	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
373153001544	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
373153001545	RNase E interface [polypeptide binding]; other site
373153001546	trimer interface [polypeptide binding]; other site
373153001547	active site
373153001548	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
373153001549	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
373153001550	RNA binding site [nucleotide binding]; other site
373153001551	domain interface; other site
373153001552	serine O-acetyltransferase; Region: cysE; TIGR01172
373153001553	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
373153001554	trimer interface [polypeptide binding]; other site
373153001555	active site
373153001556	substrate binding site [chemical binding]; other site
373153001557	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
373153001558	Coenzyme A binding pocket [chemical binding]; other site
373153001559	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
373153001560	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
373153001561	Coenzyme A binding pocket [chemical binding]; other site
373153001562	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
373153001563	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
373153001564	active site
373153001565	HIGH motif; other site
373153001566	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
373153001567	KMSKS motif; other site
373153001568	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
373153001569	tRNA binding surface [nucleotide binding]; other site
373153001570	anticodon binding site; other site
373153001571	Ribonuclease III family protein [Replication, recombination, and    repair]; Region: COG1939
373153001572	active site
373153001573	metal binding site [ion binding]; metal-binding site
373153001574	dimerization interface [polypeptide binding]; other site
373153001575	Regulator of polyketide synthase expression [Signal transduction mechanisms / Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2508
373153001576	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
373153001577	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
373153001578	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
373153001579	FtsX-like permease family; Region: FtsX; pfam02687
373153001580	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
373153001581	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
373153001582	Walker A/P-loop; other site
373153001583	ATP binding site [chemical binding]; other site
373153001584	Q-loop/lid; other site
373153001585	ABC transporter signature motif; other site
373153001586	Walker B; other site
373153001587	D-loop; other site
373153001588	H-loop/switch region; other site
373153001589	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
373153001590	FtsX-like permease family; Region: FtsX; pfam02687
373153001591	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
373153001592	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
373153001593	active site
373153001594	phosphorylation site [posttranslational modification]
373153001595	intermolecular recognition site; other site
373153001596	dimerization interface [polypeptide binding]; other site
373153001597	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
373153001598	DNA binding site [nucleotide binding]
373153001599	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
373153001600	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
373153001601	dimerization interface [polypeptide binding]; other site
373153001602	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
373153001603	dimer interface [polypeptide binding]; other site
373153001604	phosphorylation site [posttranslational modification]
373153001605	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
373153001606	ATP binding site [chemical binding]; other site
373153001607	Mg2+ binding site [ion binding]; other site
373153001608	G-X-G motif; other site
373153001609	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
373153001610	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
373153001611	intersubunit interface [polypeptide binding]; other site
373153001612	active site
373153001613	zinc binding site [ion binding]; other site
373153001614	Na+ binding site [ion binding]; other site
373153001615	Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097
373153001616	Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794
373153001617	NAD(P) binding domain of  ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198
373153001618	FAD binding pocket [chemical binding]; other site
373153001619	FAD binding motif [chemical binding]; other site
373153001620	phosphate binding motif [ion binding]; other site
373153001621	beta-alpha-beta structure motif; other site
373153001622	NAD binding pocket [chemical binding]; other site
373153001623	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
373153001624	dimer interface [polypeptide binding]; other site
373153001625	conserved gate region; other site
373153001626	putative PBP binding loops; other site
373153001627	ABC-ATPase subunit interface; other site
373153001628	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
373153001629	dimer interface [polypeptide binding]; other site
373153001630	conserved gate region; other site
373153001631	putative PBP binding loops; other site
373153001632	ABC-ATPase subunit interface; other site
373153001633	bifunctional adhesin/ABC transporter aspartate/glutamate-binding protein; Reviewed; Region: PRK11917
373153001634	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
373153001635	substrate binding pocket [chemical binding]; other site
373153001636	membrane-bound complex binding site; other site
373153001637	hinge residues; other site
373153001638	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
373153001639	DHH family; Region: DHH; pfam01368
373153001640	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4199
373153001641	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
373153001642	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
373153001643	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
373153001644	Predicted esterase [General function prediction only]; Region: COG0627
373153001645	S-formylglutathione hydrolase; Region: PLN02442
373153001646	Peptidoglycan interpeptide bridge formation enzyme [Cell wall/membrane/envelope biogenesis]; Region: COG2348
373153001647	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
373153001648	FemAB family; Region: FemAB; pfam02388
373153001649	Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268
373153001650	active site
373153001651	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
373153001652	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
373153001653	GIY-YIG motif/motif A; other site
373153001654	active site
373153001655	catalytic site [active]
373153001656	putative DNA binding site [nucleotide binding]; other site
373153001657	metal binding site [ion binding]; metal-binding site
373153001658	UvrB/uvrC motif; Region: UVR; pfam02151
373153001659	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
373153001660	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
373153001661	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
373153001662	active site
373153001663	metal binding site [ion binding]; metal-binding site
373153001664	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
373153001665	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
373153001666	substrate binding pocket [chemical binding]; other site
373153001667	membrane-bound complex binding site; other site
373153001668	hinge residues; other site
373153001669	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
373153001670	dimer interface [polypeptide binding]; other site
373153001671	FMN binding site [chemical binding]; other site
373153001672	dipeptidase PepV; Reviewed; Region: PRK07318
373153001673	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
373153001674	active site
373153001675	metal binding site [ion binding]; metal-binding site
373153001676	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
373153001677	putative uracil binding site [chemical binding]; other site
373153001678	putative active site [active]
373153001679	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
373153001680	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
373153001681	active site residue [active]
373153001682	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
373153001683	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
373153001684	M42 Peptidase, Endoglucanase-like subfamily; Region: M42_glucanase_like; cd05657
373153001685	putative oligomer interface [polypeptide binding]; other site
373153001686	putative active site [active]
373153001687	metal binding site [ion binding]; metal-binding site
373153001688	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
373153001689	nucleotide binding site/active site [active]
373153001690	HIT family signature motif; other site
373153001691	catalytic residue [active]
373153001692	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: VanY; COG1876
373153001693	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
373153001694	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
373153001695	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
373153001696	23S rRNA interface [nucleotide binding]; other site
373153001697	L7/L12 interface [polypeptide binding]; other site
373153001698	putative thiostrepton binding site; other site
373153001699	L25 interface [polypeptide binding]; other site
373153001700	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
373153001701	mRNA/rRNA interface [nucleotide binding]; other site
373153001702	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cl00251
373153001703	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586
373153001704	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
373153001705	Walker A/P-loop; other site
373153001706	ATP binding site [chemical binding]; other site
373153001707	Q-loop/lid; other site
373153001708	ABC transporter signature motif; other site
373153001709	Walker B; other site
373153001710	D-loop; other site
373153001711	H-loop/switch region; other site
373153001712	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
373153001713	ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496
373153001714	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG3694
373153001715	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587
373153001716	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
373153001717	Peptidase S8 family domain in Streptococcal C5a peptidases; Region: Peptidases_S8_C5a_Peptidase; cd07475
373153001718	putative active site [active]
373153001719	catalytic triad [active]
373153001720	PA_2: Protease-associated (PA) domain subgroup 2. A subgroup of PA-domain containing proteins. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is...; Region: PA_2; cd04819
373153001721	PA/protease or protease-like domain interface [polypeptide binding]; other site
373153001722	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
373153001723	catalytic residues [active]
373153001724	Fn3-like domain (DUF1034); Region: DUF1034; pfam06280
373153001725	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
373153001726	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
373153001727	active site
373153001728	phosphorylation site [posttranslational modification]
373153001729	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
373153001730	active site
373153001731	P-loop; other site
373153001732	phosphorylation site [posttranslational modification]
373153001733	Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775
373153001734	PTS system sugar-specific permease component; Region: EIIC-GAT; pfam03611
373153001735	YSIRK type signal peptide; Region: YSIRK_signal; pfam04650
373153001736	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
373153001737	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
373153001738	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
373153001739	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
373153001740	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
373153001741	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
373153001742	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
373153001743	Bacterial Ig-like domain (group 4); Region: Big_4; pfam07532
373153001744	G5 domain; Region: G5; pfam07501
373153001745	Protein of unknown function (DUF3397); Region: DUF3397; pfam11877
373153001746	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
373153001747	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
373153001748	Putative rRNA methylase; Region: rRNA_methylase; pfam06962
373153001749	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
373153001750	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
373153001751	Ribonuclease BN family enzyme [Replication, recombination, and repair]; Region: Rbn; COG1295
373153001752	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
373153001753	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
373153001754	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
373153001755	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
373153001756	catalytic residues [active]
373153001757	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
373153001758	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
373153001759	SelR domain; Region: SelR; pfam01641
373153001760	Response regulator receiver domain; Region: Response_reg; pfam00072
373153001761	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
373153001762	active site
373153001763	phosphorylation site [posttranslational modification]
373153001764	intermolecular recognition site; other site
373153001765	dimerization interface [polypeptide binding]; other site
373153001766	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
373153001767	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
373153001768	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
373153001769	Cache domain; Region: Cache_1; pfam02743
373153001770	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
373153001771	dimerization interface [polypeptide binding]; other site
373153001772	Histidine kinase; Region: His_kinase; pfam06580
373153001773	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
373153001774	ATP binding site [chemical binding]; other site
373153001775	Mg2+ binding site [ion binding]; other site
373153001776	G-X-G motif; other site
373153001777	hypothetical protein; Provisional; Region: PRK13690
373153001778	Gram positive anchor; Region: Gram_pos_anchor; pfam00746
373153001779	G5 domain; Region: G5; pfam07501
373153001780	M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342
373153001781	M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580
373153001782	aminodeoxychorismate synthase; Provisional; Region: PRK07508
373153001783	aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553
373153001784	substrate-cofactor binding pocket; other site
373153001785	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
373153001786	Aminotransferase class IV; Region: Aminotran_4; pfam01063
373153001787	pyridoxal 5'-phosphate binding site [chemical binding]; other site
373153001788	catalytic residue [active]
373153001789	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
373153001790	Excalibur calcium-binding domain; Region: Excalibur; smart00894
373153001791	Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553
373153001792	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
373153001793	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
373153001794	nucleotide binding site [chemical binding]; other site
373153001795	thymidylate synthase; Reviewed; Region: thyA; PRK01827
373153001796	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
373153001797	dimerization interface [polypeptide binding]; other site
373153001798	active site
373153001799	Protein of unknown function (DUF3042); Region: DUF3042; pfam11240
373153001800	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
373153001801	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
373153001802	GTPases [General function prediction only]; Region: HflX; COG2262
373153001803	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
373153001804	HflX GTPase family; Region: HflX; cd01878
373153001805	G1 box; other site
373153001806	GTP/Mg2+ binding site [chemical binding]; other site
373153001807	Switch I region; other site
373153001808	G2 box; other site
373153001809	G3 box; other site
373153001810	Switch II region; other site
373153001811	G4 box; other site
373153001812	G5 box; other site
373153001813	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
373153001814	ribonuclease Z; Region: RNase_Z; TIGR02651
373153001815	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
373153001816	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
373153001817	NAD(P) binding site [chemical binding]; other site
373153001818	active site
373153001819	Transcriptional regulator [Transcription]; Region: LysR; COG0583
373153001820	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
373153001821	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
373153001822	dimerization interface [polypeptide binding]; other site
373153001823	Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014
373153001824	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
373153001825	active site residue [active]
373153001826	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
373153001827	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
373153001828	RNA binding surface [nucleotide binding]; other site
373153001829	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
373153001830	active site
373153001831	uracil binding [chemical binding]; other site
373153001832	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
373153001833	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
373153001834	G1 box; other site
373153001835	putative GEF interaction site [polypeptide binding]; other site
373153001836	GTP/Mg2+ binding site [chemical binding]; other site
373153001837	Switch I region; other site
373153001838	G2 box; other site
373153001839	G3 box; other site
373153001840	Switch II region; other site
373153001841	G4 box; other site
373153001842	G5 box; other site
373153001843	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
373153001844	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
373153001845	Protein of unknown function (DUF3165); Region: DUF3165; pfam11364
373153001846	Bacteriocin (Lactococcin_972); Region: Lactococcin_972; pfam09683
373153001847	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652
373153001848	Protein of unknown function (DUF1430); Region: DUF1430; pfam07242
373153001849	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
373153001850	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
373153001851	Walker A/P-loop; other site
373153001852	ATP binding site [chemical binding]; other site
373153001853	Q-loop/lid; other site
373153001854	ABC transporter signature motif; other site
373153001855	Walker B; other site
373153001856	D-loop; other site
373153001857	H-loop/switch region; other site
373153001858	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
373153001859	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
373153001860	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
373153001861	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
373153001862	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
373153001863	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
373153001864	homodimer interface [polypeptide binding]; other site
373153001865	active site
373153001866	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
373153001867	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
373153001868	Cell division protein FtsQ; Region: FtsQ; pfam03799
373153001869	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
373153001870	Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cl17196
373153001871	ATP binding site [chemical binding]; other site
373153001872	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
373153001873	active site
373153001874	dimer interface [polypeptide binding]; other site
373153001875	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
373153001876	active site
373153001877	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
373153001878	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
373153001879	Walker A/P-loop; other site
373153001880	ATP binding site [chemical binding]; other site
373153001881	Q-loop/lid; other site
373153001882	ABC transporter signature motif; other site
373153001883	Walker B; other site
373153001884	D-loop; other site
373153001885	H-loop/switch region; other site
373153001886	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
373153001887	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
373153001888	Walker A/P-loop; other site
373153001889	ATP binding site [chemical binding]; other site
373153001890	Q-loop/lid; other site
373153001891	ABC transporter signature motif; other site
373153001892	Walker B; other site
373153001893	D-loop; other site
373153001894	H-loop/switch region; other site
373153001895	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
373153001896	dimer interface [polypeptide binding]; other site
373153001897	conserved gate region; other site
373153001898	putative PBP binding loops; other site
373153001899	ABC-ATPase subunit interface; other site
373153001900	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
373153001901	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
373153001902	dimer interface [polypeptide binding]; other site
373153001903	conserved gate region; other site
373153001904	putative PBP binding loops; other site
373153001905	ABC-ATPase subunit interface; other site
373153001906	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
373153001907	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
373153001908	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
373153001909	dimer interface [polypeptide binding]; other site
373153001910	putative anticodon binding site; other site
373153001911	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
373153001912	motif 1; other site
373153001913	active site
373153001914	motif 2; other site
373153001915	motif 3; other site
373153001916	L-lactate oxidase; Region: L_lactate_ox; TIGR02708
373153001917	L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2.  This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737
373153001918	teramer interface [polypeptide binding]; other site
373153001919	active site
373153001920	FMN binding site [chemical binding]; other site
373153001921	catalytic residues [active]
373153001922	Putative transcription activator [Transcription]; Region: TenA; COG0819
373153001923	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
373153001924	substrate binding site [chemical binding]; other site
373153001925	multimerization interface [polypeptide binding]; other site
373153001926	ATP binding site [chemical binding]; other site
373153001927	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
373153001928	thiamine phosphate binding site [chemical binding]; other site
373153001929	active site
373153001930	pyrophosphate binding site [ion binding]; other site
373153001931	ABC-type cobalt transport system, predicted permease component [Inorganic ion transport and metabolism]; Region: COG4721
373153001932	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
373153001933	Walker A/P-loop; other site
373153001934	ATP binding site [chemical binding]; other site
373153001935	ABC transporter; Region: ABC_tran; pfam00005
373153001936	Q-loop/lid; other site
373153001937	ABC transporter signature motif; other site
373153001938	Walker B; other site
373153001939	D-loop; other site
373153001940	H-loop/switch region; other site
373153001941	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
373153001942	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
373153001943	Walker A/P-loop; other site
373153001944	ATP binding site [chemical binding]; other site
373153001945	Q-loop/lid; other site
373153001946	ABC transporter signature motif; other site
373153001947	Walker B; other site
373153001948	D-loop; other site
373153001949	H-loop/switch region; other site
373153001950	Putative transcription activator [Transcription]; Region: TenA; COG0819
373153001951	Predicted membrane protein [Function unknown]; Region: COG4732
373153001952	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
373153001953	substrate binding site [chemical binding]; other site
373153001954	multimerization interface [polypeptide binding]; other site
373153001955	ATP binding site [chemical binding]; other site
373153001956	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
373153001957	thiamine phosphate binding site [chemical binding]; other site
373153001958	active site
373153001959	pyrophosphate binding site [ion binding]; other site
373153001960	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
373153001961	dimer interface [polypeptide binding]; other site
373153001962	substrate binding site [chemical binding]; other site
373153001963	ATP binding site [chemical binding]; other site
373153001964	Predicted transcriptional regulator [Transcription]; Region: COG3682
373153001965	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
373153001966	Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473
373153001967	Cupredoxin-like domain; Region: Cupredoxin_1; cl17234
373153001968	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
373153001969	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
373153001970	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
373153001971	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
373153001972	pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720
373153001973	PYR/PP interface [polypeptide binding]; other site
373153001974	dimer interface [polypeptide binding]; other site
373153001975	tetramer interface [polypeptide binding]; other site
373153001976	TPP binding site [chemical binding]; other site
373153001977	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
373153001978	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
373153001979	TPP-binding site [chemical binding]; other site
373153001980	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
373153001981	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
373153001982	active site
373153001983	DDE superfamily endonuclease; Region: DDE_3; pfam13358
373153001984	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
373153001985	Winged helix-turn helix; Region: HTH_29; pfam13551
373153001986	Winged helix-turn helix; Region: HTH_33; pfam13592
373153001987	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
373153001988	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
373153001989	Sodium:neurotransmitter symporter family; Region: SNF; cl11976
373153001990	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
373153001991	Na2 binding site [ion binding]; other site
373153001992	putative substrate binding site 1 [chemical binding]; other site
373153001993	Na binding site 1 [ion binding]; other site
373153001994	putative substrate binding site 2 [chemical binding]; other site
373153001995	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
373153001996	putative active site [active]
373153001997	nucleotide binding site [chemical binding]; other site
373153001998	nudix motif; other site
373153001999	putative metal binding site [ion binding]; other site
373153002000	HI0933-like protein; Region: HI0933_like; pfam03486
373153002001	Uncharacterized protein conserved in bacteria [Function unknown]; Region: DegV; COG1307
373153002002	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
373153002003	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
373153002004	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
373153002005	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
373153002006	catalytic motif [active]
373153002007	Zn binding site [ion binding]; other site
373153002008	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
373153002009	active site
373153002010	Clp protease; Region: CLP_protease; pfam00574
373153002011	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
373153002012	oligomer interface [polypeptide binding]; other site
373153002013	active site residues [active]
373153002014	hypothetical protein; Provisional; Region: PRK02302
373153002015	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
373153002016	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
373153002017	putative ligand binding site [chemical binding]; other site
373153002018	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
373153002019	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
373153002020	TM-ABC transporter signature motif; other site
373153002021	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
373153002022	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
373153002023	TM-ABC transporter signature motif; other site
373153002024	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
373153002025	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
373153002026	Walker A/P-loop; other site
373153002027	ATP binding site [chemical binding]; other site
373153002028	Q-loop/lid; other site
373153002029	ABC transporter signature motif; other site
373153002030	Walker B; other site
373153002031	D-loop; other site
373153002032	H-loop/switch region; other site
373153002033	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
373153002034	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
373153002035	Walker A/P-loop; other site
373153002036	ATP binding site [chemical binding]; other site
373153002037	Q-loop/lid; other site
373153002038	ABC transporter signature motif; other site
373153002039	Walker B; other site
373153002040	D-loop; other site
373153002041	H-loop/switch region; other site
373153002042	FOG: CBS domain [General function prediction only]; Region: COG0517
373153002043	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc2; cd04585
373153002044	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cd02116
373153002045	peptide chain release factor 2; Region: prfB; TIGR00020
373153002046	PCRF domain; Region: PCRF; pfam03462
373153002047	RF-1 domain; Region: RF-1; pfam00472
373153002048	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
373153002049	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
373153002050	Walker A/P-loop; other site
373153002051	ATP binding site [chemical binding]; other site
373153002052	Q-loop/lid; other site
373153002053	ABC transporter signature motif; other site
373153002054	Walker B; other site
373153002055	D-loop; other site
373153002056	H-loop/switch region; other site
373153002057	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
373153002058	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
373153002059	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
373153002060	PTS system, IIBC component; Region: PTS-II-BC-unk1; TIGR02003
373153002061	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
373153002062	active site turn [active]
373153002063	phosphorylation site [posttranslational modification]
373153002064	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
373153002065	HPr interaction site; other site
373153002066	glycerol kinase (GK) interaction site [polypeptide binding]; other site
373153002067	active site
373153002068	phosphorylation site [posttranslational modification]
373153002069	Streptococcus agalactiae RgfB, part of a putative two component signal transduction system, and related proteins; Region: RgfB-like; cd09079
373153002070	putative catalytic site [active]
373153002071	putative metal binding site [ion binding]; other site
373153002072	putative phosphate binding site [ion binding]; other site
373153002073	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
373153002074	DEAD-like helicases superfamily; Region: DEXDc; smart00487
373153002075	ATP binding site [chemical binding]; other site
373153002076	Mg++ binding site [ion binding]; other site
373153002077	motif III; other site
373153002078	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
373153002079	nucleotide binding region [chemical binding]; other site
373153002080	ATP-binding site [chemical binding]; other site
373153002081	S-adenosylmethionine synthetase; Validated; Region: PRK05250
373153002082	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
373153002083	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
373153002084	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
373153002085	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
373153002086	Dihydroorotate dehydrogenase (DHOD) class 1A FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1A_like; cd04741
373153002087	active site
373153002088	FMN binding site [chemical binding]; other site
373153002089	substrate binding site [chemical binding]; other site
373153002090	catalytic residues [active]
373153002091	homodimer interface [polypeptide binding]; other site
373153002092	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
373153002093	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
373153002094	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
373153002095	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
373153002096	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
373153002097	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4470
373153002098	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14455
373153002099	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
373153002100	FeS/SAM binding site; other site
373153002101	VanZ like family; Region: VanZ; pfam04892
373153002102	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
373153002103	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
373153002104	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
373153002105	ABC transporter; Region: ABC_tran_2; pfam12848
373153002106	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
373153002107	Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652
373153002108	active site
373153002109	Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228
373153002110	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
373153002111	KH domain; Region: KH_4; pfam13083
373153002112	G-X-X-G motif; other site
373153002113	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
373153002114	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
373153002115	RimM N-terminal domain; Region: RimM; pfam01782
373153002116	PRC-barrel domain; Region: PRC; pfam05239
373153002117	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
373153002118	ATP cone domain; Region: ATP-cone; pfam03477
373153002119	Uncharacterized protein conserved in bacteria (DUF2128); Region: DUF2128; pfam09901
373153002120	Uncharacterized conserved protein [General function prediction only]; Region: BioY; COG1268
373153002121	glutathione reductase; Validated; Region: PRK06116
373153002122	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
373153002123	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
373153002124	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
373153002125	Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845
373153002126	HlyD family secretion protein; Region: HlyD_3; pfam13437
373153002127	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
373153002128	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
373153002129	Walker A/P-loop; other site
373153002130	ATP binding site [chemical binding]; other site
373153002131	Q-loop/lid; other site
373153002132	ABC transporter signature motif; other site
373153002133	Walker B; other site
373153002134	D-loop; other site
373153002135	H-loop/switch region; other site
373153002136	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
373153002137	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
373153002138	FtsX-like permease family; Region: FtsX; pfam02687
373153002139	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
373153002140	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
373153002141	active site
373153002142	HIGH motif; other site
373153002143	KMSKS motif; other site
373153002144	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
373153002145	tRNA binding surface [nucleotide binding]; other site
373153002146	anticodon binding site; other site
373153002147	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
373153002148	dimer interface [polypeptide binding]; other site
373153002149	putative tRNA-binding site [nucleotide binding]; other site
373153002150	Predicted transcriptional regulators [Transcription]; Region: COG1695
373153002151	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
373153002152	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
373153002153	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
373153002154	active site
373153002155	catalytic tetrad [active]
373153002156	Protein of unknown function (DUF2829); Region: DUF2829; pfam11195
373153002157	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550
373153002158	classical (c) SDRs; Region: SDR_c; cd05233
373153002159	NAD(P) binding site [chemical binding]; other site
373153002160	active site
373153002161	Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684
373153002162	nudix motif; other site
373153002163	GNAT acetyltransferase; Region: GNAT_acetyltran; pfam12746
373153002164	Phosphoenolpyruvate synthase/pyruvate phosphate dikinase [Carbohydrate transport and metabolism]; Region: PpsA; COG0574
373153002165	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
373153002166	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
373153002167	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
373153002168	Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601
373153002169	Zn binding site [ion binding]; other site
373153002170	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
373153002171	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
373153002172	active site
373153002173	phosphorylation site [posttranslational modification]
373153002174	intermolecular recognition site; other site
373153002175	dimerization interface [polypeptide binding]; other site
373153002176	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
373153002177	DNA binding site [nucleotide binding]
373153002178	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
373153002179	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
373153002180	dimer interface [polypeptide binding]; other site
373153002181	phosphorylation site [posttranslational modification]
373153002182	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
373153002183	ATP binding site [chemical binding]; other site
373153002184	Mg2+ binding site [ion binding]; other site
373153002185	G-X-G motif; other site
373153002186	Protein of unknown function (DUF3270); Region: DUF3270; pfam11674
373153002187	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
373153002188	Peptidase family U32; Region: Peptidase_U32; pfam01136
373153002189	bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK07246
373153002190	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
373153002191	active site
373153002192	catalytic site [active]
373153002193	substrate binding site [chemical binding]; other site
373153002194	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
373153002195	ATP binding site [chemical binding]; other site
373153002196	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
373153002197	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
373153002198	DJ-1 family protein; Region: not_thiJ; TIGR01383
373153002199	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
373153002200	conserved cys residue [active]
373153002201	haloacid dehalogenase superfamily, subfamily IA, variant 1 with third motif having Dx(3-4)D or Dx(3-4)E; Region: HAD-SF-IA-v1; TIGR01549
373153002202	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
373153002203	motif II; other site
373153002204	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
373153002205	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
373153002206	Mg2+ binding site [ion binding]; other site
373153002207	G-X-G motif; other site
373153002208	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
373153002209	anchoring element; other site
373153002210	dimer interface [polypeptide binding]; other site
373153002211	ATP binding site [chemical binding]; other site
373153002212	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
373153002213	active site
373153002214	putative metal-binding site [ion binding]; other site
373153002215	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
373153002216	Negative regulator of septation ring formation [Cell division and chromosome partitioning]; Region: EzrA; COG4477
373153002217	Homeodomain-like domain; Region: HTH_32; pfam13565
373153002218	Winged helix-turn helix; Region: HTH_29; pfam13551
373153002219	DDE superfamily endonuclease; Region: DDE_3; pfam13358
373153002220	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
373153002221	Domain of unknown function (DUF1827); Region: DUF1827; pfam08860
373153002222	Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684
373153002223	nudix motif; other site
373153002224	Helix-turn-helix domain; Region: HTH_28; pfam13518
373153002225	Winged helix-turn helix; Region: HTH_29; pfam13551
373153002226	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
373153002227	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
373153002228	Walker A motif; other site
373153002229	ATP binding site [chemical binding]; other site
373153002230	Walker B motif; other site
373153002231	arginine finger; other site
373153002232	UvrB/uvrC motif; Region: UVR; pfam02151
373153002233	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
373153002234	Walker A motif; other site
373153002235	ATP binding site [chemical binding]; other site
373153002236	Walker B motif; other site
373153002237	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
373153002238	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4703
373153002239	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
373153002240	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
373153002241	dimer interface [polypeptide binding]; other site
373153002242	conserved gate region; other site
373153002243	putative PBP binding loops; other site
373153002244	ABC-ATPase subunit interface; other site
373153002245	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
373153002246	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
373153002247	Walker A/P-loop; other site
373153002248	ATP binding site [chemical binding]; other site
373153002249	Q-loop/lid; other site
373153002250	ABC transporter signature motif; other site
373153002251	Walker B; other site
373153002252	D-loop; other site
373153002253	H-loop/switch region; other site
373153002254	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14179
373153002255	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
373153002256	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
373153002257	homodimer interface [polypeptide binding]; other site
373153002258	NADP binding site [chemical binding]; other site
373153002259	substrate binding site [chemical binding]; other site
373153002260	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
373153002261	putative substrate binding site [chemical binding]; other site
373153002262	putative ATP binding site [chemical binding]; other site
373153002263	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
373153002264	tetramer (dimer of dimers) interface [polypeptide binding]; other site
373153002265	active site
373153002266	dimer interface [polypeptide binding]; other site
373153002267	phosphopentomutase; Provisional; Region: PRK05362
373153002268	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
373153002269	purine nucleoside phosphorylase; Provisional; Region: PRK08202
373153002270	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741
373153002271	nucleophilic elbow; other site
373153002272	catalytic triad; other site
373153002273	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
373153002274	Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289
373153002275	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
373153002276	topology modulation protein; Provisional; Region: PRK07261
373153002277	AAA domain; Region: AAA_17; pfam13207
373153002278	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
373153002279	pantothenate kinase; Provisional; Region: PRK05439
373153002280	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
373153002281	ATP-binding site [chemical binding]; other site
373153002282	CoA-binding site [chemical binding]; other site
373153002283	Mg2+-binding site [ion binding]; other site
373153002284	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
373153002285	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
373153002286	S-adenosylmethionine binding site [chemical binding]; other site
373153002287	pyrimidine-nucleoside phosphorylase; Reviewed; Region: PRK06078
373153002288	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
373153002289	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
373153002290	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831
373153002291	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
373153002292	intersubunit interface [polypeptide binding]; other site
373153002293	active site
373153002294	catalytic residue [active]
373153002295	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
373153002296	active site
373153002297	catalytic motif [active]
373153002298	Zn binding site [ion binding]; other site
373153002299	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
373153002300	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
373153002301	ligand binding site [chemical binding]; other site
373153002302	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
373153002303	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
373153002304	Walker A/P-loop; other site
373153002305	ATP binding site [chemical binding]; other site
373153002306	Q-loop/lid; other site
373153002307	ABC transporter signature motif; other site
373153002308	Walker B; other site
373153002309	D-loop; other site
373153002310	H-loop/switch region; other site
373153002311	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
373153002312	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
373153002313	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
373153002314	TM-ABC transporter signature motif; other site
373153002315	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
373153002316	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
373153002317	TM-ABC transporter signature motif; other site
373153002318	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
373153002319	DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058
373153002320	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
373153002321	Mg2+ binding site [ion binding]; other site
373153002322	G-X-G motif; other site
373153002323	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
373153002324	anchoring element; other site
373153002325	dimer interface [polypeptide binding]; other site
373153002326	ATP binding site [chemical binding]; other site
373153002327	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
373153002328	active site
373153002329	putative metal-binding site [ion binding]; other site
373153002330	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
373153002331	DNA topoisomerase IV, A subunit, Gram-positive; Region: parC_Gpos; TIGR01061
373153002332	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
373153002333	CAP-like domain; other site
373153002334	active site
373153002335	primary dimer interface [polypeptide binding]; other site
373153002336	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
373153002337	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
373153002338	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
373153002339	homodimer interface [polypeptide binding]; other site
373153002340	substrate-cofactor binding pocket; other site
373153002341	catalytic residue [active]
373153002342	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
373153002343	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
373153002344	Predicted membrane protein [Function unknown]; Region: COG3819
373153002345	Predicted membrane protein [Function unknown]; Region: COG3817
373153002346	Protein of unknown function (DUF979); Region: DUF979; pfam06166
373153002347	Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I:  Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501
373153002348	putative substrate binding pocket [chemical binding]; other site
373153002349	AC domain interface; other site
373153002350	catalytic triad [active]
373153002351	AB domain interface; other site
373153002352	interchain disulfide; other site
373153002353	Protein of unknown function (DUF2969); Region: DUF2969; pfam11184
373153002354	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
373153002355	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
373153002356	RNA binding site [nucleotide binding]; other site
373153002357	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
373153002358	RNA binding site [nucleotide binding]; other site
373153002359	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
373153002360	RNA binding site [nucleotide binding]; other site
373153002361	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
373153002362	RNA binding site [nucleotide binding]; other site
373153002363	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
373153002364	GAF domain; Region: GAF_2; pfam13185
373153002365	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
373153002366	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
373153002367	Walker A motif; other site
373153002368	ATP binding site [chemical binding]; other site
373153002369	Walker B motif; other site
373153002370	arginine finger; other site
373153002371	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
373153002372	Protein of unknown function (DUF3272); Region: DUF3272; pfam11676
373153002373	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
373153002374	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
373153002375	Walker A/P-loop; other site
373153002376	ATP binding site [chemical binding]; other site
373153002377	Q-loop/lid; other site
373153002378	ABC transporter signature motif; other site
373153002379	Walker B; other site
373153002380	D-loop; other site
373153002381	H-loop/switch region; other site
373153002382	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
373153002383	FeS assembly protein SufD; Region: sufD; TIGR01981
373153002384	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
373153002385	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
373153002386	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
373153002387	catalytic residue [active]
373153002388	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
373153002389	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
373153002390	trimerization site [polypeptide binding]; other site
373153002391	active site
373153002392	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
373153002393	FeS assembly protein SufB; Region: sufB; TIGR01980
373153002394	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
373153002395	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
373153002396	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
373153002397	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
373153002398	Domain of unknown function DUF20; Region: UPF0118; pfam01594
373153002399	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
373153002400	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
373153002401	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
373153002402	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
373153002403	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
373153002404	putative substrate binding site [chemical binding]; other site
373153002405	putative ATP binding site [chemical binding]; other site
373153002406	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
373153002407	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
373153002408	active site
373153002409	phosphorylation site [posttranslational modification]
373153002410	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
373153002411	active site
373153002412	P-loop; other site
373153002413	phosphorylation site [posttranslational modification]
373153002414	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
373153002415	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
373153002416	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
373153002417	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
373153002418	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
373153002419	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
373153002420	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
373153002421	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
373153002422	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
373153002423	catalytic residue [active]
373153002424	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
373153002425	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
373153002426	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
373153002427	Ligand Binding Site [chemical binding]; other site
373153002428	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
373153002429	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947
373153002430	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947
373153002431	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
373153002432	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
373153002433	HsdM N-terminal domain; Region: HsdM_N; pfam12161
373153002434	Methyltransferase domain; Region: Methyltransf_26; pfam13659
373153002435	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
373153002436	Domain of unknown function (DUF4145); Region: DUF4145; pfam13643
373153002437	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
373153002438	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
373153002439	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
373153002440	ATP binding site [chemical binding]; other site
373153002441	putative Mg++ binding site [ion binding]; other site
373153002442	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
373153002443	Arginine repressor [Transcription]; Region: ArgR; COG1438
373153002444	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
373153002445	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
373153002446	x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371
373153002447	X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; pfam09168
373153002448	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
373153002449	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK07279
373153002450	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
373153002451	active site
373153002452	PHP Thumb interface [polypeptide binding]; other site
373153002453	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
373153002454	generic binding surface II; other site
373153002455	generic binding surface I; other site
373153002456	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
373153002457	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
373153002458	active site
373153002459	ADP/pyrophosphate binding site [chemical binding]; other site
373153002460	dimerization interface [polypeptide binding]; other site
373153002461	allosteric effector site; other site
373153002462	fructose-1,6-bisphosphate binding site; other site
373153002463	pyruvate kinase; Provisional; Region: PRK05826
373153002464	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
373153002465	domain interfaces; other site
373153002466	active site
373153002467	Domain of unknown function (DUF4300); Region: DUF4300; pfam14133
373153002468	Predicted membrane protein [Function unknown]; Region: COG3689
373153002469	Predicted permeases [General function prediction only]; Region: COG0701
373153002470	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
373153002471	active site
373153002472	Domain of unknown function (DUF1919); Region: DUF1919; cl01628
373153002473	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
373153002474	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
373153002475	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
373153002476	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
373153002477	RNA binding site [nucleotide binding]; other site
373153002478	Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983
373153002479	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
373153002480	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
373153002481	Walker A/P-loop; other site
373153002482	ATP binding site [chemical binding]; other site
373153002483	Q-loop/lid; other site
373153002484	ABC transporter signature motif; other site
373153002485	Walker B; other site
373153002486	D-loop; other site
373153002487	H-loop/switch region; other site
373153002488	FtsX-like permease family; Region: FtsX; pfam02687
373153002489	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
373153002490	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
373153002491	Helix-turn-helix domain; Region: HTH_38; pfam13936
373153002492	Integrase core domain; Region: rve; pfam00665
373153002493	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
373153002494	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
373153002495	homodimer interface [polypeptide binding]; other site
373153002496	pyridoxal 5'-phosphate binding site [chemical binding]; other site
373153002497	catalytic residue [active]
373153002498	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
373153002499	spermidine synthase; Provisional; Region: PRK00811
373153002500	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
373153002501	S-adenosylmethionine binding site [chemical binding]; other site
373153002502	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
373153002503	Shikimate / quinate 5-dehydrogenase; Region: Shikimate_DH; pfam01488
373153002504	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
373153002505	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
373153002506	dimer interface [polypeptide binding]; other site
373153002507	active site
373153002508	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
373153002509	catalytic residues [active]
373153002510	substrate binding site [chemical binding]; other site
373153002511	agmatine deiminase; Provisional; Region: PRK13551
373153002512	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
373153002513	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
373153002514	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
373153002515	putative active site; other site
373153002516	catalytic triad [active]
373153002517	putative dimer interface [polypeptide binding]; other site
373153002518	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
373153002519	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
373153002520	active site
373153002521	motif I; other site
373153002522	motif II; other site
373153002523	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
373153002524	CAAX protease self-immunity; Region: Abi; pfam02517
373153002525	Transcriptional regulator [Transcription]; Region: LysR; COG0583
373153002526	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
373153002527	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
373153002528	dimerization interface [polypeptide binding]; other site
373153002529	lipoprotein signal peptidase; Provisional; Region: PRK14797
373153002530	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
373153002531	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
373153002532	RNA binding surface [nucleotide binding]; other site
373153002533	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
373153002534	active site
373153002535	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
373153002536	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
373153002537	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
373153002538	Glutamate 5-kinase [Amino acid transport and metabolism]; Region: ProB; COG0263
373153002539	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
373153002540	nucleotide binding site [chemical binding]; other site
373153002541	homotetrameric interface [polypeptide binding]; other site
373153002542	putative phosphate binding site [ion binding]; other site
373153002543	putative allosteric binding site; other site
373153002544	PUA domain; Region: PUA; pfam01472
373153002545	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
373153002546	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
373153002547	putative catalytic cysteine [active]
373153002548	pyrroline-5-carboxylate reductase; Region: PLN02688
373153002549	Pyrroline-5-carboxylate reductase [Amino acid transport and metabolism]; Region: ProC; COG0345
373153002550	thymidylate kinase; Validated; Region: tmk; PRK00698
373153002551	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
373153002552	TMP-binding site; other site
373153002553	ATP-binding site [chemical binding]; other site
373153002554	DNA polymerase III subunit delta'; Validated; Region: PRK07276
373153002555	DNA polymerase III subunit delta'; Validated; Region: PRK08485
373153002556	DNA replication intiation control protein YabA; Reviewed; Region: PRK13169
373153002557	Predicted methyltransferases [General function prediction only]; Region: COG0313
373153002558	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
373153002559	putative SAM binding site [chemical binding]; other site
373153002560	putative homodimer interface [polypeptide binding]; other site
373153002561	Protein of unknown function (DUF1706); Region: DUF1706; pfam08020
373153002562	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
373153002563	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
373153002564	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
373153002565	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
373153002566	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
373153002567	Glucose inhibited division protein A; Region: GIDA; pfam01134
373153002568	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
373153002569	putative nucleotide binding site [chemical binding]; other site
373153002570	uridine monophosphate binding site [chemical binding]; other site
373153002571	homohexameric interface [polypeptide binding]; other site
373153002572	ribosome recycling factor; Reviewed; Region: frr; PRK00083
373153002573	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
373153002574	hinge region; other site
373153002575	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
373153002576	S1 domain; Region: S1_2; pfam13509
373153002577	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
373153002578	hypothetical protein; Provisional; Region: PRK13672
373153002579	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
373153002580	PhoH-like protein; Region: PhoH; pfam02562
373153002581	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
373153002582	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
373153002583	Coenzyme A binding pocket [chemical binding]; other site
373153002584	Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070
373153002585	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
373153002586	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
373153002587	SLBB domain; Region: SLBB; pfam10531
373153002588	comEA protein; Region: comE; TIGR01259
373153002589	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
373153002590	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
373153002591	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
373153002592	Competence protein; Region: Competence; pfam03772
373153002593	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
373153002594	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
373153002595	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
373153002596	Walker A/P-loop; other site
373153002597	ATP binding site [chemical binding]; other site
373153002598	ABC transporter; Region: ABC_tran; pfam00005
373153002599	Q-loop/lid; other site
373153002600	ABC transporter signature motif; other site
373153002601	Walker B; other site
373153002602	D-loop; other site
373153002603	SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685
373153002604	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
373153002605	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
373153002606	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
373153002607	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
373153002608	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
373153002609	23S rRNA binding site [nucleotide binding]; other site
373153002610	L21 binding site [polypeptide binding]; other site
373153002611	L13 binding site [polypeptide binding]; other site
373153002612	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
373153002613	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
373153002614	dimer interface [polypeptide binding]; other site
373153002615	active site
373153002616	metal binding site [ion binding]; metal-binding site
373153002617	glutathione binding site [chemical binding]; other site
373153002618	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
373153002619	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
373153002620	FAD binding pocket [chemical binding]; other site
373153002621	FAD binding motif [chemical binding]; other site
373153002622	phosphate binding motif [ion binding]; other site
373153002623	beta-alpha-beta structure motif; other site
373153002624	NAD binding pocket [chemical binding]; other site
373153002625	Iron coordination center [ion binding]; other site
373153002626	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
373153002627	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
373153002628	heterodimer interface [polypeptide binding]; other site
373153002629	active site
373153002630	FMN binding site [chemical binding]; other site
373153002631	homodimer interface [polypeptide binding]; other site
373153002632	substrate binding site [chemical binding]; other site
373153002633	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
373153002634	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
373153002635	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
373153002636	Domain of unknown function (DUF814); Region: DUF814; pfam05670
373153002637	metal-binding heat shock protein; Provisional; Region: PRK00016
373153002638	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
373153002639	GTPase Era; Reviewed; Region: era; PRK00089
373153002640	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
373153002641	G1 box; other site
373153002642	GTP/Mg2+ binding site [chemical binding]; other site
373153002643	Switch I region; other site
373153002644	G2 box; other site
373153002645	Switch II region; other site
373153002646	G3 box; other site
373153002647	G4 box; other site
373153002648	G5 box; other site
373153002649	KH domain; Region: KH_2; pfam07650
373153002650	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
373153002651	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
373153002652	DNA binding site [nucleotide binding]
373153002653	catalytic residue [active]
373153002654	H2TH interface [polypeptide binding]; other site
373153002655	putative catalytic residues [active]
373153002656	turnover-facilitating residue; other site
373153002657	intercalation triad [nucleotide binding]; other site
373153002658	8OG recognition residue [nucleotide binding]; other site
373153002659	putative reading head residues; other site
373153002660	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
373153002661	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
373153002662	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
373153002663	dephospho-CoA kinase; Region: TIGR00152
373153002664	CoA-binding site [chemical binding]; other site
373153002665	ATP-binding [chemical binding]; other site
373153002666	drug efflux system protein MdtG; Provisional; Region: PRK09874
373153002667	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
373153002668	putative substrate translocation pore; other site
373153002669	Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314
373153002670	ribonuclease R; Region: RNase_R; TIGR02063
373153002671	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
373153002672	RNB domain; Region: RNB; pfam00773
373153002673	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
373153002674	RNA binding site [nucleotide binding]; other site
373153002675	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
373153002676	SmpB-tmRNA interface; other site
373153002677	tellurite resistance protein TehB; Provisional; Region: PRK12335
373153002678	Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615
373153002679	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
373153002680	S-adenosylmethionine binding site [chemical binding]; other site
373153002681	Competence protein CoiA-like family, contains a predicted nuclease    domain [General function prediction only]; Region: CoiA; COG4469
373153002682	Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164
373153002683	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
373153002684	active site
373153002685	Zn binding site [ion binding]; other site
373153002686	Predicted O-methyltransferase [General function prediction only]; Region: COG4122
373153002687	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
373153002688	S-adenosylmethionine binding site [chemical binding]; other site
373153002689	foldase protein PrsA; Reviewed; Region: prsA; PRK01326
373153002690	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
373153002691	Integrase core domain; Region: rve; pfam00665
373153002692	Integrase core domain; Region: rve_3; cl15866
373153002693	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
373153002694	catalytic core [active]
373153002695	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
373153002696	putative deacylase active site [active]
373153002697	Predicted membrane protein [Function unknown]; Region: COG2035
373153002698	Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757
373153002699	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
373153002700	active site
373153002701	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
373153002702	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
373153002703	Substrate binding site; other site
373153002704	Mg++ binding site; other site
373153002705	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
373153002706	active site
373153002707	substrate binding site [chemical binding]; other site
373153002708	CoA binding site [chemical binding]; other site
373153002709	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
373153002710	dimer interface [polypeptide binding]; other site
373153002711	ADP-ribose binding site [chemical binding]; other site
373153002712	active site
373153002713	nudix motif; other site
373153002714	metal binding site [ion binding]; metal-binding site
373153002715	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
373153002716	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
373153002717	MarR family; Region: MarR_2; cl17246
373153002718	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
373153002719	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
373153002720	active site
373153002721	catalytic site [active]
373153002722	substrate binding site [chemical binding]; other site
373153002723	Membrane domain of membrane-anchored glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: COG4781
373153002724	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
373153002725	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
373153002726	putative active site [active]
373153002727	catalytic site [active]
373153002728	putative metal binding site [ion binding]; other site
373153002729	DDE superfamily endonuclease; Region: DDE_3; pfam13358
373153002730	Transmembrane domain of the Epidermal Growth Factor Receptor family of Protein Tyrosine Kinases; Region: TM_EGFR-like; cl17045
373153002731	dimer interface [polypeptide binding]; other site
373153002732	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
373153002733	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
373153002734	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
373153002735	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
373153002736	catalytic residues [active]
373153002737	amino acid transporter; Region: 2A0306; TIGR00909
373153002738	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
373153002739	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
373153002740	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
373153002741	metal binding site [ion binding]; metal-binding site
373153002742	streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363
373153002743	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
373153002744	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
373153002745	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
373153002746	streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363
373153002747	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
373153002748	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
373153002749	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
373153002750	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
373153002751	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
373153002752	peptidase T; Region: peptidase-T; TIGR01882
373153002753	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
373153002754	metal binding site [ion binding]; metal-binding site
373153002755	dimer interface [polypeptide binding]; other site
373153002756	Protoheme ferro-lyase (ferrochelatase) [Coenzyme metabolism]; Region: HemH; COG0276
373153002757	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
373153002758	C-terminal domain interface [polypeptide binding]; other site
373153002759	active site
373153002760	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
373153002761	active site
373153002762	N-terminal domain interface [polypeptide binding]; other site
373153002763	Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970
373153002764	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
373153002765	Predicted membrane protein [Function unknown]; Region: COG2246
373153002766	GtrA-like protein; Region: GtrA; pfam04138
373153002767	Predicted membrane protein [Function unknown]; Region: COG4708
373153002768	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
373153002769	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
373153002770	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
373153002771	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
373153002772	dimer interface [polypeptide binding]; other site
373153002773	active site
373153002774	catalytic residue [active]
373153002775	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
373153002776	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
373153002777	trmE is a tRNA modification GTPase; Region: trmE; cd04164
373153002778	G1 box; other site
373153002779	GTP/Mg2+ binding site [chemical binding]; other site
373153002780	Switch I region; other site
373153002781	G2 box; other site
373153002782	Switch II region; other site
373153002783	G3 box; other site
373153002784	G4 box; other site
373153002785	G5 box; other site
373153002786	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
373153002787	4-oxalocrotonate tautomerase; Provisional; Region: PRK02289
373153002788	active site 1 [active]
373153002789	dimer interface [polypeptide binding]; other site
373153002790	hexamer interface [polypeptide binding]; other site
373153002791	active site 2 [active]
373153002792	thymidine kinase; Provisional; Region: PRK04296
373153002793	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
373153002794	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
373153002795	Coenzyme A binding pocket [chemical binding]; other site
373153002796	peptide chain release factor 1; Validated; Region: prfA; PRK00591
373153002797	This domain is found in peptide chain release factors; Region: PCRF; smart00937
373153002798	RF-1 domain; Region: RF-1; pfam00472
373153002799	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
373153002800	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
373153002801	S-adenosylmethionine binding site [chemical binding]; other site
373153002802	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
373153002803	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
373153002804	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
373153002805	Coenzyme A binding pocket [chemical binding]; other site
373153002806	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
373153002807	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
373153002808	dimer interface [polypeptide binding]; other site
373153002809	active site
373153002810	glycine-pyridoxal phosphate binding site [chemical binding]; other site
373153002811	folate binding site [chemical binding]; other site
373153002812	37-kD nucleoid-associated bacterial protein; Region: NA37; cl15473
373153002813	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
373153002814	Lysozyme-like; Region: Lysozyme_like; pfam13702
373153002815	Predicted secreted protein [Function unknown]; Region: COG4086
373153002816	Protein of unknown function (DUF1002); Region: DUF1002; pfam06207
373153002817	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
373153002818	TRAM domain; Region: TRAM; cl01282
373153002819	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
373153002820	S-adenosylmethionine binding site [chemical binding]; other site
373153002821	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
373153002822	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
373153002823	siderophore binding site; other site
373153002824	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
373153002825	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
373153002826	ABC-ATPase subunit  interface; other site
373153002827	dimer interface [polypeptide binding]; other site
373153002828	putative PBP binding regions; other site
373153002829	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
373153002830	ABC-ATPase subunit  interface; other site
373153002831	dimer interface [polypeptide binding]; other site
373153002832	putative PBP binding regions; other site
373153002833	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
373153002834	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
373153002835	Walker A/P-loop; other site
373153002836	ATP binding site [chemical binding]; other site
373153002837	Q-loop/lid; other site
373153002838	ABC transporter signature motif; other site
373153002839	Walker B; other site
373153002840	D-loop; other site
373153002841	H-loop/switch region; other site
373153002842	Domain of unknown function (DUF4286); Region: DUF4286; pfam14114
373153002843	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
373153002844	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
373153002845	catalytic residues [active]
373153002846	catalytic nucleophile [active]
373153002847	Recombinase; Region: Recombinase; pfam07508
373153002848	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
373153002849	Domain of unknown function (DUF4343); Region: DUF4343; pfam14243
373153002850	ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397
373153002851	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
373153002852	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
373153002853	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
373153002854	homodimer interface [polypeptide binding]; other site
373153002855	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
373153002856	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
373153002857	active site
373153002858	homodimer interface [polypeptide binding]; other site
373153002859	catalytic site [active]
373153002860	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
373153002861	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
373153002862	non-specific DNA binding site [nucleotide binding]; other site
373153002863	salt bridge; other site
373153002864	sequence-specific DNA binding site [nucleotide binding]; other site
373153002865	Zeta toxin; Region: Zeta_toxin; pfam06414
373153002866	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
373153002867	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
373153002868	AAA domain; Region: AAA_21; pfam13304
373153002869	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
373153002870	ABC transporter signature motif; other site
373153002871	Walker B; other site
373153002872	D-loop; other site
373153002873	H-loop/switch region; other site
373153002874	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
373153002875	Lantibiotic streptin immunity protein; Region: Streptin-Immun; pfam11083
373153002876	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
373153002877	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
373153002878	non-specific DNA binding site [nucleotide binding]; other site
373153002879	salt bridge; other site
373153002880	sequence-specific DNA binding site [nucleotide binding]; other site
373153002881	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
373153002882	nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026
373153002883	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
373153002884	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
373153002885	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
373153002886	GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585
373153002887	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
373153002888	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
373153002889	Metal-binding active site; metal-binding site
373153002890	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
373153002891	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
373153002892	trimer interface [polypeptide binding]; other site
373153002893	active site
373153002894	substrate binding site [chemical binding]; other site
373153002895	CoA binding site [chemical binding]; other site
373153002896	O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923
373153002897	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
373153002898	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
373153002899	acyl-activating enzyme (AAE) consensus motif; other site
373153002900	acyl-activating enzyme (AAE) consensus motif; other site
373153002901	AMP binding site [chemical binding]; other site
373153002902	active site
373153002903	CoA binding site [chemical binding]; other site
373153002904	Histidyl-tRNA synthetase; Region: tRNA-synt_His; pfam13393
373153002905	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
373153002906	motif 1; other site
373153002907	dimer interface [polypeptide binding]; other site
373153002908	active site
373153002909	motif 2; other site
373153002910	motif 3; other site
373153002911	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
373153002912	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
373153002913	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
373153002914	putative trimer interface [polypeptide binding]; other site
373153002915	putative CoA binding site [chemical binding]; other site
373153002916	H+ Antiporter protein; Region: 2A0121; TIGR00900
373153002917	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
373153002918	putative substrate translocation pore; other site
373153002919	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
373153002920	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
373153002921	sequence-specific DNA binding site [nucleotide binding]; other site
373153002922	salt bridge; other site
373153002923	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
373153002924	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
373153002925	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
373153002926	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
373153002927	zinc binding site [ion binding]; other site
373153002928	putative ligand binding site [chemical binding]; other site
373153002929	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
373153002930	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
373153002931	TM-ABC transporter signature motif; other site
373153002932	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
373153002933	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
373153002934	Walker A/P-loop; other site
373153002935	ATP binding site [chemical binding]; other site
373153002936	Q-loop/lid; other site
373153002937	ABC transporter signature motif; other site
373153002938	Walker B; other site
373153002939	D-loop; other site
373153002940	H-loop/switch region; other site
373153002941	DNA primase; Validated; Region: dnaG; PRK05667
373153002942	CHC2 zinc finger; Region: zf-CHC2; pfam01807
373153002943	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
373153002944	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
373153002945	active site
373153002946	metal binding site [ion binding]; metal-binding site
373153002947	interdomain interaction site; other site
373153002948	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
373153002949	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
373153002950	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
373153002951	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
373153002952	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
373153002953	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
373153002954	DNA binding residues [nucleotide binding]
373153002955	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
373153002956	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
373153002957	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
373153002958	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
373153002959	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
373153002960	putative ADP-binding pocket [chemical binding]; other site
373153002961	Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983
373153002962	Protein of unknown function (DUF4044); Region: DUF4044; pfam13253
373153002963	GTPase CgtA; Reviewed; Region: obgE; PRK12297
373153002964	GTP1/OBG; Region: GTP1_OBG; pfam01018
373153002965	Obg GTPase; Region: Obg; cd01898
373153002966	G1 box; other site
373153002967	GTP/Mg2+ binding site [chemical binding]; other site
373153002968	Switch I region; other site
373153002969	G2 box; other site
373153002970	G3 box; other site
373153002971	Switch II region; other site
373153002972	G4 box; other site
373153002973	G5 box; other site
373153002974	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
373153002975	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
373153002976	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
373153002977	hinge; other site
373153002978	active site
373153002979	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
373153002980	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
373153002981	Predicted transcriptional regulator containing CBS domains [Transcription]; Region: COG4109
373153002982	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
373153002983	DNA-binding site [nucleotide binding]; DNA binding site
373153002984	DRTGG domain; Region: DRTGG; pfam07085
373153002985	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with a DRTGG domain upstream. The function of the DRTGG domain, named after its conserved residues, is unknown. CBS is a small domain originally...; Region: CBS_pair_DRTGG_assoc; cd04596
373153002986	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
373153002987	active site 2 [active]
373153002988	active site 1 [active]
373153002989	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
373153002990	active site
373153002991	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
373153002992	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
373153002993	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
373153002994	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
373153002995	Part of AAA domain; Region: AAA_19; pfam13245
373153002996	Family description; Region: UvrD_C_2; pfam13538
373153002997	hypothetical protein; Reviewed; Region: PRK00024
373153002998	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
373153002999	MPN+ (JAMM) motif; other site
373153003000	Zinc-binding site [ion binding]; other site
373153003001	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
373153003002	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
373153003003	catalytic triad [active]
373153003004	AT-rich DNA-binding protein [General function prediction only]; Region: COG2344
373153003005	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
373153003006	CoA binding domain; Region: CoA_binding; pfam02629
373153003007	Putative amino acid metabolism; Region: DUF1831; pfam08866
373153003008	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
373153003009	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
373153003010	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
373153003011	catalytic residue [active]
373153003012	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02458
373153003013	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
373153003014	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
373153003015	active site
373153003016	Uncharacterized subgroup 1 of the CYTH-like superfamily; Region: CYTH-like_Pase_1; cd07762
373153003017	putative active site [active]
373153003018	putative metal binding residues [ion binding]; other site
373153003019	signature motif; other site
373153003020	putative triphosphate binding site [ion binding]; other site
373153003021	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
373153003022	synthetase active site [active]
373153003023	NTP binding site [chemical binding]; other site
373153003024	metal binding site [ion binding]; metal-binding site
373153003025	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
373153003026	ATP-NAD kinase; Region: NAD_kinase; pfam01513
373153003027	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
373153003028	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
373153003029	RNA binding surface [nucleotide binding]; other site
373153003030	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
373153003031	active site
373153003032	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
373153003033	hypothetical protein; Validated; Region: PRK00153
373153003034	Predicted membrane protein [Function unknown]; Region: COG3619
373153003035	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
373153003036	Predicted ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG2868
373153003037	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
373153003038	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
373153003039	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
373153003040	active site
373153003041	Riboflavin kinase; Region: Flavokinase; smart00904
373153003042	Uncharacterized conserved protein [Function unknown]; Region: COG1284
373153003043	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
373153003044	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
373153003045	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
373153003046	EDD domain protein, DegV family; Region: DegV; TIGR00762
373153003047	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
373153003048	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
373153003049	IHF dimer interface [polypeptide binding]; other site
373153003050	IHF - DNA interface [nucleotide binding]; other site
373153003051	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
373153003052	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
373153003053	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
373153003054	ABC transporter; Region: ABC_tran_2; pfam12848
373153003055	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
373153003056	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
373153003057	non-specific DNA binding site [nucleotide binding]; other site
373153003058	salt bridge; other site
373153003059	sequence-specific DNA binding site [nucleotide binding]; other site
373153003060	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
373153003061	H+ Antiporter protein; Region: 2A0121; TIGR00900
373153003062	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
373153003063	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
373153003064	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
373153003065	nucleotide binding pocket [chemical binding]; other site
373153003066	K-X-D-G motif; other site
373153003067	catalytic site [active]
373153003068	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
373153003069	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
373153003070	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
373153003071	Dimer interface [polypeptide binding]; other site
373153003072	BRCT sequence motif; other site
373153003073	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cl04227
373153003074	pullulanase, type I; Region: pulA_typeI; TIGR02104
373153003075	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
373153003076	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
373153003077	Ca binding site [ion binding]; other site
373153003078	active site
373153003079	catalytic site [active]
373153003080	NADP+-dependent non-phosphorylating glyceraldehyde 3-phosphate dehydrogenase and ALDH family 11; Region: ALDH_F11_NP-GAPDH; cd07082
373153003081	NADP-dependent glyceraldehyde-3-phosphate dehydrogenase; Provisional; Region: PLN00412
373153003082	tetrameric interface [polypeptide binding]; other site
373153003083	activator binding site; other site
373153003084	NADP binding site [chemical binding]; other site
373153003085	substrate binding site [chemical binding]; other site
373153003086	catalytic residues [active]
373153003087	glycogen branching enzyme; Provisional; Region: PRK12313
373153003088	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
373153003089	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
373153003090	active site
373153003091	catalytic site [active]
373153003092	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
373153003093	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
373153003094	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
373153003095	ligand binding site; other site
373153003096	oligomer interface; other site
373153003097	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
373153003098	dimer interface [polypeptide binding]; other site
373153003099	N-terminal domain interface [polypeptide binding]; other site
373153003100	sulfate 1 binding site; other site
373153003101	glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092
373153003102	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
373153003103	active site
373153003104	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
373153003105	dimer interface [polypeptide binding]; other site
373153003106	N-terminal domain interface [polypeptide binding]; other site
373153003107	sulfate 1 binding site; other site
373153003108	glycogen synthase; Provisional; Region: glgA; PRK00654
373153003109	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
373153003110	ADP-binding pocket [chemical binding]; other site
373153003111	homodimer interface [polypeptide binding]; other site
373153003112	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
373153003113	Uncharacterized conserved protein [Function unknown]; Region: COG5506
373153003114	enolase; Provisional; Region: eno; PRK00077
373153003115	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
373153003116	dimer interface [polypeptide binding]; other site
373153003117	metal binding site [ion binding]; metal-binding site
373153003118	substrate binding pocket [chemical binding]; other site
373153003119	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
373153003120	DNA binding site [nucleotide binding]
373153003121	active site
373153003122	Int/Topo IB signature motif; other site
373153003123	Transposase; Region: HTH_Tnp_IS630; pfam01710
373153003124	Helix-turn-helix domain; Region: HTH_28; pfam13518
373153003125	ATP-dependent nuclease subunit B; Region: rexB_recomb; TIGR02774
373153003126	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
373153003127	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
373153003128	Part of AAA domain; Region: AAA_19; pfam13245
373153003129	Family description; Region: UvrD_C_2; pfam13538
373153003130	Family description; Region: UvrD_C_2; pfam13538
373153003131	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
373153003132	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
373153003133	G5 domain; Region: G5; pfam07501
373153003134	M26 IgA1-specific Metallo-endopeptidase N-terminal region; Region: Peptidase_M26_N; pfam05342
373153003135	M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580
373153003136	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
373153003137	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
373153003138	GTP/Mg2+ binding site [chemical binding]; other site
373153003139	G4 box; other site
373153003140	G5 box; other site
373153003141	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
373153003142	G1 box; other site
373153003143	G1 box; other site
373153003144	GTP/Mg2+ binding site [chemical binding]; other site
373153003145	Switch I region; other site
373153003146	G2 box; other site
373153003147	G2 box; other site
373153003148	G3 box; other site
373153003149	G3 box; other site
373153003150	Switch II region; other site
373153003151	Switch II region; other site
373153003152	G5 box; other site
373153003153	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
373153003154	RNA/DNA hybrid binding site [nucleotide binding]; other site
373153003155	active site
373153003156	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
373153003157	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
373153003158	Cl- selectivity filter; other site
373153003159	Cl- binding residues [ion binding]; other site
373153003160	pore gating glutamate residue; other site
373153003161	dimer interface [polypeptide binding]; other site
373153003162	H+/Cl- coupling transport residue; other site
373153003163	TrkA-C domain; Region: TrkA_C; pfam02080
373153003164	site-specific tyrosine recombinase XerS; Reviewed; Region: xerS; PRK05084
373153003165	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
373153003166	active site
373153003167	DNA binding site [nucleotide binding]
373153003168	Int/Topo IB signature motif; other site
373153003169	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
373153003170	lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545
373153003171	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
373153003172	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
373153003173	E3 interaction surface; other site
373153003174	lipoyl attachment site [posttranslational modification]; other site
373153003175	dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350
373153003176	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
373153003177	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
373153003178	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
373153003179	dihydrolipoamide acetyltransferase; Provisional; Region: PRK14843
373153003180	e3 binding domain; Region: E3_binding; pfam02817
373153003181	e3 binding domain; Region: E3_binding; pfam02817
373153003182	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
373153003183	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
373153003184	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
373153003185	alpha subunit interface [polypeptide binding]; other site
373153003186	TPP binding site [chemical binding]; other site
373153003187	heterodimer interface [polypeptide binding]; other site
373153003188	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
373153003189	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, alpha subunit [Energy production and conversion]; Region: AcoA; COG1071
373153003190	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
373153003191	tetramer interface [polypeptide binding]; other site
373153003192	TPP-binding site [chemical binding]; other site
373153003193	heterodimer interface [polypeptide binding]; other site
373153003194	phosphorylation loop region [posttranslational modification]
373153003195	multidrug efflux protein; Reviewed; Region: PRK01766
373153003196	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
373153003197	cation binding site [ion binding]; other site
373153003198	dihydroorotase; Validated; Region: pyrC; PRK09357
373153003199	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
373153003200	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
373153003201	active site
373153003202	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
373153003203	putative active site [active]
373153003204	nucleotide binding site [chemical binding]; other site
373153003205	nudix motif; other site
373153003206	putative metal binding site [ion binding]; other site
373153003207	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
373153003208	ligand binding site [chemical binding]; other site
373153003209	active site
373153003210	UGI interface [polypeptide binding]; other site
373153003211	catalytic site [active]
373153003212	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
373153003213	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
373153003214	motif II; other site
373153003215	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
373153003216	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
373153003217	streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363
373153003218	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
373153003219	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
373153003220	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
373153003221	streptococcal histidine triad protein; Region: strep_his_triad; TIGR01363
373153003222	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
373153003223	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
373153003224	Streptococcal histidine triad protein; Region: Strep_his_triad; pfam04270
373153003225	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
373153003226	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
373153003227	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
373153003228	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
373153003229	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
373153003230	dimerization domain swap beta strand [polypeptide binding]; other site
373153003231	regulatory protein interface [polypeptide binding]; other site
373153003232	active site
373153003233	regulatory phosphorylation site [posttranslational modification]; other site
373153003234	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
373153003235	catalytic residues [active]
373153003236	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306
373153003237	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
373153003238	Class I ribonucleotide reductase; Region: RNR_I; cd01679
373153003239	active site
373153003240	dimer interface [polypeptide binding]; other site
373153003241	catalytic residues [active]
373153003242	effector binding site; other site
373153003243	R2 peptide binding site; other site
373153003244	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
373153003245	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
373153003246	dimer interface [polypeptide binding]; other site
373153003247	putative radical transfer pathway; other site
373153003248	diiron center [ion binding]; other site
373153003249	tyrosyl radical; other site
373153003250	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
373153003251	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
373153003252	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
373153003253	Protein of unknown function (DUF3884); Region: DUF3884; pfam13024
373153003254	6-phospho-beta-galactosidase; Provisional; Region: PRK13511
373153003255	beta-galactosidase; Region: BGL; TIGR03356
373153003256	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; cl17295
373153003257	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
373153003258	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
373153003259	active site
373153003260	P-loop; other site
373153003261	phosphorylation site [posttranslational modification]
373153003262	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
373153003263	methionine cluster; other site
373153003264	active site
373153003265	phosphorylation site [posttranslational modification]
373153003266	metal binding site [ion binding]; metal-binding site
373153003267	CAT RNA binding domain; Region: CAT_RBD; smart01061
373153003268	transcriptional antiterminator BglG; Provisional; Region: PRK09772
373153003269	PRD domain; Region: PRD; pfam00874
373153003270	PRD domain; Region: PRD; pfam00874
373153003271	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399
373153003272	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
373153003273	tagatose-6-phosphate kinase; Region: lacC; TIGR01231
373153003274	putative substrate binding site [chemical binding]; other site
373153003275	putative ATP binding site [chemical binding]; other site
373153003276	galactose-6-phosphate isomerase subunit LacB; Reviewed; Region: PRK08622
373153003277	galactose-6-phosphate isomerase subunit LacA; Reviewed; Region: PRK08621
373153003278	aldose 1-epimerase superfamily; Region: Aldose_epim; cl14648
373153003279	catalytic residues [active]
373153003280	PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS).  In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566
373153003281	active site
373153003282	P-loop; other site
373153003283	phosphorylation site [posttranslational modification]
373153003284	GTP-binding protein LepA; Provisional; Region: PRK05433
373153003285	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
373153003286	G1 box; other site
373153003287	putative GEF interaction site [polypeptide binding]; other site
373153003288	GTP/Mg2+ binding site [chemical binding]; other site
373153003289	Switch I region; other site
373153003290	G2 box; other site
373153003291	G3 box; other site
373153003292	Switch II region; other site
373153003293	G4 box; other site
373153003294	G5 box; other site
373153003295	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
373153003296	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
373153003297	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
373153003298	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
373153003299	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
373153003300	active site
373153003301	metal binding site [ion binding]; metal-binding site
373153003302	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
373153003303	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
373153003304	Walker A/P-loop; other site
373153003305	ATP binding site [chemical binding]; other site
373153003306	Q-loop/lid; other site
373153003307	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
373153003308	ABC transporter signature motif; other site
373153003309	Walker B; other site
373153003310	D-loop; other site
373153003311	H-loop/switch region; other site
373153003312	Arginine repressor [Transcription]; Region: ArgR; COG1438
373153003313	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
373153003314	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
373153003315	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
373153003316	S4 RNA-binding domain; Region: S4; smart00363
373153003317	RNA binding surface [nucleotide binding]; other site
373153003318	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
373153003319	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
373153003320	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
373153003321	substrate binding pocket [chemical binding]; other site
373153003322	chain length determination region; other site
373153003323	substrate-Mg2+ binding site; other site
373153003324	catalytic residues [active]
373153003325	aspartate-rich region 1; other site
373153003326	active site lid residues [active]
373153003327	aspartate-rich region 2; other site
373153003328	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
373153003329	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
373153003330	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
373153003331	generic binding surface II; other site
373153003332	generic binding surface I; other site
373153003333	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
373153003334	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
373153003335	Sugar specificity; other site
373153003336	Pyrimidine base specificity; other site
373153003337	ATP-binding site [chemical binding]; other site
373153003338	Enterocin A Immunity; Region: EntA_Immun; pfam08951
373153003339	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK02484
373153003340	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
373153003341	RNA binding site [nucleotide binding]; other site
373153003342	active site
373153003343	tRNA Pseudouridine synthase II, C terminal; Region: TruB_C; pfam09142
373153003344	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
373153003345	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4487
373153003346	Uncharacterized protein conserved in bacteria (DUF2130); Region: DUF2130; pfam09903
373153003347	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
373153003348	hypothetical protein; Provisional; Region: PRK05939
373153003349	homodimer interface [polypeptide binding]; other site
373153003350	substrate-cofactor binding pocket; other site
373153003351	pyridoxal 5'-phosphate binding site [chemical binding]; other site
373153003352	catalytic residue [active]
373153003353	Dppa2/4 conserved region; Region: DCR; pfam14047
373153003354	Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116
373153003355	Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165
373153003356	active site
373153003357	catalytic site [active]
373153003358	DNA gyrase subunit A; Validated; Region: PRK05560
373153003359	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
373153003360	CAP-like domain; other site
373153003361	active site
373153003362	primary dimer interface [polypeptide binding]; other site
373153003363	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
373153003364	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
373153003365	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
373153003366	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
373153003367	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
373153003368	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
373153003369	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
373153003370	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
373153003371	tetramer (dimer of dimers) interface [polypeptide binding]; other site
373153003372	NAD binding site [chemical binding]; other site
373153003373	dimer interface [polypeptide binding]; other site
373153003374	substrate binding site [chemical binding]; other site
373153003375	This entry represents the putative helicase A859L; Region: T5orf172; smart00974
373153003376	DEAD-like helicases superfamily; Region: DEXDc; smart00487
373153003377	Domain of unknown function (DUF947); Region: DUF947; pfam06102
373153003378	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
373153003379	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
373153003380	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
373153003381	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
373153003382	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
373153003383	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
373153003384	putative active site [active]
373153003385	heme pocket [chemical binding]; other site
373153003386	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
373153003387	dimer interface [polypeptide binding]; other site
373153003388	phosphorylation site [posttranslational modification]
373153003389	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
373153003390	ATP binding site [chemical binding]; other site
373153003391	Mg2+ binding site [ion binding]; other site
373153003392	G-X-G motif; other site
373153003393	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
373153003394	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
373153003395	active site
373153003396	phosphorylation site [posttranslational modification]
373153003397	intermolecular recognition site; other site
373153003398	dimerization interface [polypeptide binding]; other site
373153003399	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
373153003400	DNA binding site [nucleotide binding]
373153003401	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
373153003402	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
373153003403	minor groove reading motif; other site
373153003404	helix-hairpin-helix signature motif; other site
373153003405	substrate binding pocket [chemical binding]; other site
373153003406	active site
373153003407	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
373153003408	DNA binding and oxoG recognition site [nucleotide binding]
373153003409	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
373153003410	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
373153003411	Potassium binding sites [ion binding]; other site
373153003412	Cesium cation binding sites [ion binding]; other site
373153003413	phosphopantothenate--cysteine ligase; Validated; Region: PRK06732
373153003414	phosphopantothenoylcysteine decarboxylase, streptococcal; Region: coaC_strep; TIGR02113
373153003415	Flavoprotein; Region: Flavoprotein; pfam02441
373153003416	Predicted membrane protein [Function unknown]; Region: COG4684
373153003417	Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827
373153003418	HTH domain; Region: HTH_11; pfam08279
373153003419	3H domain; Region: 3H; pfam02829
373153003420	MutT homolog-1 (MTH1) is a member of the Nudix hydrolase superfamily. MTH1, the mammalian counterpart of MutT, hydrolyzes oxidized purine nucleoside triphosphates, such as 8-oxo-dGTP and 2-hydroxy-ATP, to monophosphates, thereby preventing the...; Region: MTH1; cd03427
373153003421	putative active site [active]
373153003422	nucleotide binding site [chemical binding]; other site
373153003423	nudix motif; other site
373153003424	putative metal binding site [ion binding]; other site
373153003425	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
373153003426	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
373153003427	Coenzyme A binding pocket [chemical binding]; other site
373153003428	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
373153003429	excinuclease ABC subunit B; Provisional; Region: PRK05298
373153003430	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
373153003431	ATP binding site [chemical binding]; other site
373153003432	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
373153003433	nucleotide binding region [chemical binding]; other site
373153003434	ATP-binding site [chemical binding]; other site
373153003435	Ultra-violet resistance protein B; Region: UvrB; pfam12344
373153003436	UvrB/uvrC motif; Region: UVR; pfam02151
373153003437	CAAX protease self-immunity; Region: Abi; pfam02517
373153003438	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
373153003439	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
373153003440	substrate binding pocket [chemical binding]; other site
373153003441	membrane-bound complex binding site; other site
373153003442	hinge residues; other site
373153003443	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
373153003444	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
373153003445	substrate binding pocket [chemical binding]; other site
373153003446	membrane-bound complex binding site; other site
373153003447	hinge residues; other site
373153003448	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
373153003449	dimer interface [polypeptide binding]; other site
373153003450	conserved gate region; other site
373153003451	putative PBP binding loops; other site
373153003452	ABC-ATPase subunit interface; other site
373153003453	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
373153003454	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
373153003455	Walker A/P-loop; other site
373153003456	ATP binding site [chemical binding]; other site
373153003457	Q-loop/lid; other site
373153003458	ABC transporter signature motif; other site
373153003459	Walker B; other site
373153003460	D-loop; other site
373153003461	H-loop/switch region; other site
373153003462	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
373153003463	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
373153003464	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
373153003465	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
373153003466	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
373153003467	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
373153003468	P loop; other site
373153003469	GTP binding site [chemical binding]; other site
373153003470	sugar phosphate phosphatase; Provisional; Region: PRK10513
373153003471	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
373153003472	motif II; other site
373153003473	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
373153003474	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
373153003475	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
373153003476	active site
373153003477	motif I; other site
373153003478	motif II; other site
373153003479	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
373153003480	Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196
373153003481	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
373153003482	Walker A/P-loop; other site
373153003483	ATP binding site [chemical binding]; other site
373153003484	Q-loop/lid; other site
373153003485	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
373153003486	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
373153003487	ABC transporter signature motif; other site
373153003488	Walker B; other site
373153003489	D-loop; other site
373153003490	H-loop/switch region; other site
373153003491	ribonuclease III; Reviewed; Region: rnc; PRK00102
373153003492	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
373153003493	dimerization interface [polypeptide binding]; other site
373153003494	active site
373153003495	metal binding site [ion binding]; metal-binding site
373153003496	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
373153003497	dsRNA binding site [nucleotide binding]; other site
373153003498	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
373153003499	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
373153003500	active site
373153003501	McrBC 5-methylcytosine restriction system component [Defense mechanisms]; Region: McrC; COG4268
373153003502	GTPase subunit of restriction endonuclease [Defense mechanisms]; Region: McrB; COG1401
373153003503	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
373153003504	Walker A motif; other site
373153003505	ATP binding site [chemical binding]; other site
373153003506	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
373153003507	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251
373153003508	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
373153003509	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
373153003510	substrate binding site [chemical binding]; other site
373153003511	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
373153003512	tartrate dehydrogenase; Region: TTC; TIGR02089
373153003513	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
373153003514	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
373153003515	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2832
373153003516	DNA topoisomerase I; Validated; Region: PRK05582
373153003517	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
373153003518	active site
373153003519	interdomain interaction site; other site
373153003520	putative metal-binding site [ion binding]; other site
373153003521	nucleotide binding site [chemical binding]; other site
373153003522	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
373153003523	domain I; other site
373153003524	DNA binding groove [nucleotide binding]
373153003525	phosphate binding site [ion binding]; other site
373153003526	domain II; other site
373153003527	domain III; other site
373153003528	nucleotide binding site [chemical binding]; other site
373153003529	catalytic site [active]
373153003530	domain IV; other site
373153003531	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
373153003532	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
373153003533	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
373153003534	Predicted membrane protein [Function unknown]; Region: COG1808
373153003535	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
373153003536	DNA protecting protein DprA; Region: dprA; TIGR00732
373153003537	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
373153003538	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
373153003539	active site
373153003540	metal-binding site
373153003541	Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151
373153003542	Phosphotransferase enzyme family; Region: APH; pfam01636
373153003543	active site
373153003544	substrate binding site [chemical binding]; other site
373153003545	ATP binding site [chemical binding]; other site
373153003546	dimer interface [polypeptide binding]; other site
373153003547	ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237
373153003548	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
373153003549	putative NAD(P) binding site [chemical binding]; other site
373153003550	putative catalytic Zn binding site [ion binding]; other site
373153003551	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
373153003552	substrate binding site; other site
373153003553	dimer interface; other site
373153003554	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
373153003555	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
373153003556	LPS biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3475
373153003557	LPS biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3475
373153003558	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
373153003559	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
373153003560	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
373153003561	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
373153003562	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
373153003563	ATP-grasp domain; Region: ATP-grasp_4; cl17255
373153003564	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
373153003565	IMP binding site; other site
373153003566	dimer interface [polypeptide binding]; other site
373153003567	interdomain contacts; other site
373153003568	partial ornithine binding site; other site
373153003569	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
373153003570	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
373153003571	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
373153003572	catalytic site [active]
373153003573	subunit interface [polypeptide binding]; other site
373153003574	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
373153003575	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
373153003576	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
373153003577	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
373153003578	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
373153003579	active site
373153003580	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
373153003581	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
373153003582	minor groove reading motif; other site
373153003583	helix-hairpin-helix signature motif; other site
373153003584	substrate binding pocket [chemical binding]; other site
373153003585	active site
373153003586	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
373153003587	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
373153003588	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
373153003589	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
373153003590	heat shock protein HtpX; Provisional; Region: PRK04897
373153003591	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
373153003592	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
373153003593	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
373153003594	S-adenosylmethionine binding site [chemical binding]; other site
373153003595	uracil transporter; Provisional; Region: PRK10720
373153003596	signal recognition particle protein; Provisional; Region: PRK10867
373153003597	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
373153003598	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
373153003599	P loop; other site
373153003600	GTP binding site [chemical binding]; other site
373153003601	Signal peptide binding domain; Region: SRP_SPB; pfam02978
373153003602	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
373153003603	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
373153003604	Domain of unknown function (DUF1934); Region: DUF1934; pfam09148
373153003605	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
373153003606	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
373153003607	Zn2+ binding site [ion binding]; other site
373153003608	Mg2+ binding site [ion binding]; other site
373153003609	sugar phosphate phosphatase; Provisional; Region: PRK10513
373153003610	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
373153003611	active site
373153003612	motif I; other site
373153003613	motif II; other site
373153003614	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
373153003615	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
373153003616	camphor resistance protein CrcB; Provisional; Region: PRK14229
373153003617	camphor resistance protein CrcB; Provisional; Region: PRK14221
373153003618	hypothetical protein; Provisional; Region: PRK07248
373153003619	flavodoxin; Validated; Region: PRK07308
373153003620	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
373153003621	DHH family; Region: DHH; pfam01368
373153003622	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
373153003623	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
373153003624	Winged helix-turn helix; Region: HTH_33; pfam13592
373153003625	glutamate dehydrogenase; Provisional; Region: PRK09414
373153003626	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
373153003627	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
373153003628	NAD(P) binding site [chemical binding]; other site
373153003629	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
373153003630	Walker A/P-loop; other site
373153003631	ATP binding site [chemical binding]; other site
373153003632	ABC transporter; Region: ABC_tran; pfam00005
373153003633	Q-loop/lid; other site
373153003634	ABC transporter signature motif; other site
373153003635	Walker B; other site
373153003636	D-loop; other site
373153003637	H-loop/switch region; other site
373153003638	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
373153003639	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
373153003640	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
373153003641	Class I aldolases; Region: Aldolase_Class_I; cl17187
373153003642	catalytic residue [active]
373153003643	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
373153003644	active site
373153003645	catalytic motif [active]
373153003646	Zn binding site [ion binding]; other site
373153003647	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
373153003648	tetramer interfaces [polypeptide binding]; other site
373153003649	binuclear metal-binding site [ion binding]; other site
373153003650	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
373153003651	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
373153003652	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
373153003653	Walker A/P-loop; other site
373153003654	ATP binding site [chemical binding]; other site
373153003655	Q-loop/lid; other site
373153003656	ABC transporter signature motif; other site
373153003657	Walker B; other site
373153003658	D-loop; other site
373153003659	H-loop/switch region; other site
373153003660	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
373153003661	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
373153003662	Walker A/P-loop; other site
373153003663	ATP binding site [chemical binding]; other site
373153003664	Q-loop/lid; other site
373153003665	ABC transporter signature motif; other site
373153003666	Walker B; other site
373153003667	D-loop; other site
373153003668	H-loop/switch region; other site
373153003669	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
373153003670	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
373153003671	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
373153003672	dimer interface [polypeptide binding]; other site
373153003673	conserved gate region; other site
373153003674	putative PBP binding loops; other site
373153003675	ABC-ATPase subunit interface; other site
373153003676	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
373153003677	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
373153003678	dimer interface [polypeptide binding]; other site
373153003679	conserved gate region; other site
373153003680	putative PBP binding loops; other site
373153003681	ABC-ATPase subunit interface; other site
373153003682	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
373153003683	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
373153003684	cyclically-permuted mutarotase family protein; Region: mutarot_permut; TIGR03548
373153003685	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
373153003686	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
373153003687	putative active site cavity [active]
373153003688	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
373153003689	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
373153003690	Walker A/P-loop; other site
373153003691	ATP binding site [chemical binding]; other site
373153003692	Q-loop/lid; other site
373153003693	ABC transporter signature motif; other site
373153003694	Walker B; other site
373153003695	D-loop; other site
373153003696	H-loop/switch region; other site
373153003697	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
373153003698	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
373153003699	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
373153003700	Walker A/P-loop; other site
373153003701	ATP binding site [chemical binding]; other site
373153003702	Q-loop/lid; other site
373153003703	ABC transporter signature motif; other site
373153003704	Walker B; other site
373153003705	D-loop; other site
373153003706	H-loop/switch region; other site
373153003707	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
373153003708	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
373153003709	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
373153003710	active site
373153003711	ATP binding site [chemical binding]; other site
373153003712	Lanthionine synthetase C-like domain associated with serine threonine kinases. Some members of this subgroup lack the zinc binding site and the active site residues, and therefore are most likely inactive. The function of this domain is unknown; Region: LanC_SerThrkinase; cd04791
373153003713	Lanthionine synthetase C-like protein; Region: LANC_like; pfam05147
373153003714	active site
373153003715	zinc binding site [ion binding]; other site
373153003716	CAAX protease self-immunity; Region: Abi; pfam02517
373153003717	Arsenate reductase and related proteins, glutaredoxin family [Inorganic ion transport and metabolism]; Region: ArsC; COG1393
373153003718	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
373153003719	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
373153003720	core dimer interface [polypeptide binding]; other site
373153003721	L10 interface [polypeptide binding]; other site
373153003722	L11 interface [polypeptide binding]; other site
373153003723	putative EF-Tu interaction site [polypeptide binding]; other site
373153003724	putative EF-G interaction site [polypeptide binding]; other site
373153003725	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
373153003726	23S rRNA interface [nucleotide binding]; other site
373153003727	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
373153003728	chlorohydrolase; Validated; Region: PRK06687
373153003729	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
373153003730	active site
373153003731	putative substrate binding pocket [chemical binding]; other site
373153003732	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
373153003733	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
373153003734	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
373153003735	Walker A/P-loop; other site
373153003736	ATP binding site [chemical binding]; other site
373153003737	Q-loop/lid; other site
373153003738	ABC transporter signature motif; other site
373153003739	Walker B; other site
373153003740	D-loop; other site
373153003741	H-loop/switch region; other site
373153003742	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
373153003743	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
373153003744	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
373153003745	Walker A/P-loop; other site
373153003746	ATP binding site [chemical binding]; other site
373153003747	Q-loop/lid; other site
373153003748	ABC transporter signature motif; other site
373153003749	Walker B; other site
373153003750	D-loop; other site
373153003751	H-loop/switch region; other site
373153003752	Peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: MsrA; COG0225
373153003753	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229
373153003754	SelR domain; Region: SelR; pfam01641
373153003755	homoserine kinase; Provisional; Region: PRK01212
373153003756	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
373153003757	homoserine dehydrogenase; Provisional; Region: PRK06349
373153003758	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
373153003759	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
373153003760	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
373153003761	adaptor protein; Provisional; Region: PRK02315
373153003762	O-antigen polysaccharide polymerase Wzy; Region: O-ag_pol_Wzy; pfam14296
373153003763	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
373153003764	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
373153003765	active site
373153003766	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
373153003767	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
373153003768	putative ADP-binding pocket [chemical binding]; other site
373153003769	LPS biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3475
373153003770	Transcriptional regulator [Transcription]; Region: LytR; COG1316
373153003771	prephenate dehydratase; Provisional; Region: PRK11898
373153003772	Prephenate dehydratase; Region: PDT; pfam00800
373153003773	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
373153003774	putative L-Phe binding site [chemical binding]; other site
373153003775	shikimate kinase; Reviewed; Region: aroK; PRK00131
373153003776	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
373153003777	ADP binding site [chemical binding]; other site
373153003778	magnesium binding site [ion binding]; other site
373153003779	putative shikimate binding site; other site
373153003780	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
373153003781	Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554
373153003782	hinge; other site
373153003783	active site
373153003784	hypothetical protein; Provisional; Region: PRK13676
373153003785	prephenate dehydrogenase; Validated; Region: PRK06545
373153003786	prephenate dehydrogenase; Validated; Region: PRK08507
373153003787	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
373153003788	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
373153003789	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
373153003790	Tetramer interface [polypeptide binding]; other site
373153003791	active site
373153003792	FMN-binding site [chemical binding]; other site
373153003793	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
373153003794	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
373153003795	active site
373153003796	dimer interface [polypeptide binding]; other site
373153003797	metal binding site [ion binding]; metal-binding site
373153003798	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
373153003799	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
373153003800	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
373153003801	shikimate binding site; other site
373153003802	NAD(P) binding site [chemical binding]; other site
373153003803	3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710
373153003804	Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502
373153003805	active site
373153003806	catalytic residue [active]
373153003807	dimer interface [polypeptide binding]; other site
373153003808	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
373153003809	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
373153003810	putative RNA binding site [nucleotide binding]; other site
373153003811	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
373153003812	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
373153003813	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
373153003814	Walker A/P-loop; other site
373153003815	ATP binding site [chemical binding]; other site
373153003816	Q-loop/lid; other site
373153003817	ABC transporter signature motif; other site
373153003818	Walker B; other site
373153003819	D-loop; other site
373153003820	H-loop/switch region; other site
373153003821	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
373153003822	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
373153003823	active site
373153003824	Na/Ca binding site [ion binding]; other site
373153003825	catalytic site [active]
373153003826	Domain of unknown function (DUF1939); Region: DUF1939; pfam09154
373153003827	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
373153003828	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
373153003829	motif 1; other site
373153003830	active site
373153003831	motif 2; other site
373153003832	motif 3; other site
373153003833	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
373153003834	DHHA1 domain; Region: DHHA1; pfam02272
373153003835	Uncharacterized conserved protein [Function unknown]; Region: COG4894
373153003836	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
373153003837	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
373153003838	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
373153003839	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
373153003840	dimer interface [polypeptide binding]; other site
373153003841	conserved gate region; other site
373153003842	putative PBP binding loops; other site
373153003843	ABC-ATPase subunit interface; other site
373153003844	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
373153003845	dimer interface [polypeptide binding]; other site
373153003846	conserved gate region; other site
373153003847	putative PBP binding loops; other site
373153003848	ABC-ATPase subunit interface; other site
373153003849	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
373153003850	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
373153003851	Walker A/P-loop; other site
373153003852	ATP binding site [chemical binding]; other site
373153003853	Q-loop/lid; other site
373153003854	ABC transporter signature motif; other site
373153003855	Walker B; other site
373153003856	D-loop; other site
373153003857	H-loop/switch region; other site
373153003858	TOBE domain; Region: TOBE_2; pfam08402
373153003859	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
373153003860	FAD binding domain; Region: FAD_binding_4; pfam01565
373153003861	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
373153003862	Putative membrane peptidase family (DUF2324); Region: DUF2324; cl01810
373153003863	Alpha-acetolactate decarboxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: AlsD; COG3527
373153003864	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
373153003865	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
373153003866	DNA-binding site [nucleotide binding]; DNA binding site
373153003867	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
373153003868	pyridoxal 5'-phosphate binding site [chemical binding]; other site
373153003869	homodimer interface [polypeptide binding]; other site
373153003870	catalytic residue [active]
373153003871	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
373153003872	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
373153003873	substrate binding pocket [chemical binding]; other site
373153003874	membrane-bound complex binding site; other site
373153003875	hinge residues; other site
373153003876	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
373153003877	PhoU domain; Region: PhoU; pfam01895
373153003878	PhoU domain; Region: PhoU; pfam01895
373153003879	phosphate transporter ATP-binding protein; Provisional; Region: PRK14239
373153003880	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
373153003881	Walker A/P-loop; other site
373153003882	ATP binding site [chemical binding]; other site
373153003883	Q-loop/lid; other site
373153003884	ABC transporter signature motif; other site
373153003885	Walker B; other site
373153003886	D-loop; other site
373153003887	H-loop/switch region; other site
373153003888	phosphate transporter ATP-binding protein; Provisional; Region: PRK14237
373153003889	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
373153003890	Walker A/P-loop; other site
373153003891	ATP binding site [chemical binding]; other site
373153003892	Q-loop/lid; other site
373153003893	ABC transporter signature motif; other site
373153003894	Walker B; other site
373153003895	D-loop; other site
373153003896	H-loop/switch region; other site
373153003897	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
373153003898	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
373153003899	dimer interface [polypeptide binding]; other site
373153003900	conserved gate region; other site
373153003901	putative PBP binding loops; other site
373153003902	ABC-ATPase subunit interface; other site
373153003903	sulfate transport protein; Provisional; Region: cysT; CHL00187
373153003904	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
373153003905	dimer interface [polypeptide binding]; other site
373153003906	conserved gate region; other site
373153003907	putative PBP binding loops; other site
373153003908	ABC-ATPase subunit interface; other site
373153003909	ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725
373153003910	phosphate binding protein; Region: ptsS_2; TIGR02136
373153003911	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
373153003912	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
373153003913	S-adenosylmethionine binding site [chemical binding]; other site
373153003914	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
373153003915	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
373153003916	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
373153003917	active site
373153003918	hypothetical protein; Provisional; Region: PRK04387
373153003919	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
373153003920	ArsC family; Region: ArsC; pfam03960
373153003921	putative catalytic residues [active]
373153003922	thiol/disulfide switch; other site
373153003923	Predicted membrane protein [Function unknown]; Region: COG4478
373153003924	HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2
373153003925	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
373153003926	active site
373153003927	motif I; other site
373153003928	motif II; other site
373153003929	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
373153003930	Acyl-ACP thioesterase [Lipid metabolism]; Region: FatA; COG3884
373153003931	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
373153003932	active site
373153003933	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
373153003934	active site
373153003935	coproporphyrinogen III oxidase; Provisional; Region: PRK08599
373153003936	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
373153003937	FeS/SAM binding site; other site
373153003938	HemN C-terminal domain; Region: HemN_C; pfam06969
373153003939	YtxH-like protein; Region: YtxH; pfam12732
373153003940	Uncharacterized protein containing a divergent version of the methyl-accepting chemotaxis-like domain [General function prediction only]; Region: COG4768
373153003941	Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790
373153003942	HPr kinase/phosphorylase; Provisional; Region: PRK05428
373153003943	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
373153003944	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
373153003945	Hpr binding site; other site
373153003946	active site
373153003947	homohexamer subunit interaction site [polypeptide binding]; other site
373153003948	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
373153003949	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
373153003950	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
373153003951	active site
373153003952	trimer interface [polypeptide binding]; other site
373153003953	allosteric site; other site
373153003954	active site lid [active]
373153003955	hexamer (dimer of trimers) interface [polypeptide binding]; other site
373153003956	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
373153003957	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
373153003958	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
373153003959	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
373153003960	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
373153003961	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
373153003962	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
373153003963	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
373153003964	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
373153003965	homodimer interface [polypeptide binding]; other site
373153003966	NAD binding pocket [chemical binding]; other site
373153003967	ATP binding pocket [chemical binding]; other site
373153003968	Mg binding site [ion binding]; other site
373153003969	active-site loop [active]
373153003970	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
373153003971	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
373153003972	active site
373153003973	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
373153003974	non-specific DNA binding site [nucleotide binding]; other site
373153003975	salt bridge; other site
373153003976	sequence-specific DNA binding site [nucleotide binding]; other site
373153003977	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
373153003978	ABC transporter; Region: ABC_tran; pfam00005
373153003979	Q-loop/lid; other site
373153003980	ABC transporter signature motif; other site
373153003981	Walker B; other site
373153003982	D-loop; other site
373153003983	H-loop/switch region; other site
373153003984	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
373153003985	Peptidase family U32; Region: Peptidase_U32; pfam01136
373153003986	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
373153003987	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
373153003988	Peptidase family U32; Region: Peptidase_U32; pfam01136
373153003989	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
373153003990	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
373153003991	S-adenosylmethionine binding site [chemical binding]; other site
373153003992	Helix-turn-helix domain; Region: HTH_18; pfam12833
373153003993	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
373153003994	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
373153003995	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
373153003996	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
373153003997	Walker A/P-loop; other site
373153003998	ATP binding site [chemical binding]; other site
373153003999	Q-loop/lid; other site
373153004000	ABC transporter signature motif; other site
373153004001	Walker B; other site
373153004002	D-loop; other site
373153004003	H-loop/switch region; other site
373153004004	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
373153004005	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
373153004006	Walker A/P-loop; other site
373153004007	ATP binding site [chemical binding]; other site
373153004008	Q-loop/lid; other site
373153004009	ABC transporter signature motif; other site
373153004010	Walker B; other site
373153004011	D-loop; other site
373153004012	H-loop/switch region; other site
373153004013	Hypothetical bacterial integral membrane protein (Trep_Strep); Region: Trep_Strep; pfam09605
373153004014	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
373153004015	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
373153004016	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
373153004017	Walker A/P-loop; other site
373153004018	ATP binding site [chemical binding]; other site
373153004019	Q-loop/lid; other site
373153004020	ABC transporter signature motif; other site
373153004021	Walker B; other site
373153004022	D-loop; other site
373153004023	H-loop/switch region; other site
373153004024	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
373153004025	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
373153004026	Walker A/P-loop; other site
373153004027	ATP binding site [chemical binding]; other site
373153004028	Q-loop/lid; other site
373153004029	ABC transporter signature motif; other site
373153004030	Walker B; other site
373153004031	D-loop; other site
373153004032	H-loop/switch region; other site
373153004033	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
373153004034	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
373153004035	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
373153004036	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
373153004037	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
373153004038	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
373153004039	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
373153004040	GMP synthase; Reviewed; Region: guaA; PRK00074
373153004041	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
373153004042	AMP/PPi binding site [chemical binding]; other site
373153004043	candidate oxyanion hole; other site
373153004044	catalytic triad [active]
373153004045	potential glutamine specificity residues [chemical binding]; other site
373153004046	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
373153004047	ATP Binding subdomain [chemical binding]; other site
373153004048	Dimerization subdomain; other site
373153004049	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
373153004050	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
373153004051	DNA-binding site [nucleotide binding]; DNA binding site
373153004052	UTRA domain; Region: UTRA; pfam07702
373153004053	EamA-like transporter family; Region: EamA; pfam00892
373153004054	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
373153004055	Beta-lactamase; Region: Beta-lactamase; pfam00144
373153004056	NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841
373153004057	active site
373153004058	catalytic triad [active]
373153004059	oxyanion hole [active]
373153004060	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
373153004061	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
373153004062	active site
373153004063	motif I; other site
373153004064	motif II; other site
373153004065	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
373153004066	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
373153004067	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
373153004068	putative active site [active]
373153004069	putative metal binding site [ion binding]; other site
373153004070	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
373153004071	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
373153004072	active site
373153004073	catalytic residues [active]
373153004074	metal binding site [ion binding]; metal-binding site
373153004075	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
373153004076	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
373153004077	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
373153004078	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
373153004079	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
373153004080	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
373153004081	Protein of unknown function (DUF4059); Region: DUF4059; pfam13268
373153004082	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
373153004083	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
373153004084	Walker A/P-loop; other site
373153004085	ATP binding site [chemical binding]; other site
373153004086	Q-loop/lid; other site
373153004087	ABC transporter signature motif; other site
373153004088	Walker B; other site
373153004089	D-loop; other site
373153004090	H-loop/switch region; other site
373153004091	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
373153004092	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
373153004093	ABC-ATPase subunit interface; other site
373153004094	putative PBP binding loops; other site
373153004095	Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036
373153004096	putative ArsC-like catalytic residues; other site
373153004097	putative TRX-like catalytic residues [active]
373153004098	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
373153004099	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
373153004100	DNA binding site [nucleotide binding]
373153004101	active site
373153004102	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
373153004103	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
373153004104	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
373153004105	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
373153004106	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
373153004107	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
373153004108	predicted active site [active]
373153004109	catalytic triad [active]
373153004110	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
373153004111	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
373153004112	active site
373153004113	multimer interface [polypeptide binding]; other site
373153004114	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
373153004115	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
373153004116	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
373153004117	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
373153004118	ApbE family; Region: ApbE; pfam02424
373153004119	Predicted flavoprotein [General function prediction only]; Region: COG0431
373153004120	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
373153004121	Predicted flavoprotein [General function prediction only]; Region: COG0431
373153004122	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
373153004123	PAS domain; Region: PAS_10; pfam13596
373153004124	hypothetical protein; Provisional; Region: PRK02539
373153004125	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
373153004126	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; smart00471
373153004127	DALR anticodon binding domain; Region: DALR_1; pfam05746
373153004128	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
373153004129	dimer interface [polypeptide binding]; other site
373153004130	motif 1; other site
373153004131	active site
373153004132	motif 2; other site
373153004133	motif 3; other site
373153004134	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
373153004135	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
373153004136	active site
373153004137	catalytic tetrad [active]
373153004138	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
373153004139	Catalytic NodB homology domain of Streptococcus pneumoniae peptidoglycan deacetylase PgdA, Bacillus subtilis BsYjeA protein, and their bacterial homologs; Region: CE4_SpPgdA_BsYjeA_like; cd10947
373153004140	NodB motif; other site
373153004141	active site
373153004142	catalytic site [active]
373153004143	Zn binding site [ion binding]; other site
373153004144	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
373153004145	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
373153004146	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
373153004147	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
373153004148	DEAD-like helicases superfamily; Region: DEXDc; smart00487
373153004149	ATP binding site [chemical binding]; other site
373153004150	putative Mg++ binding site [ion binding]; other site
373153004151	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
373153004152	nucleotide binding region [chemical binding]; other site
373153004153	ATP-binding site [chemical binding]; other site
373153004154	Winged helix-turn helix; Region: HTH_29; pfam13551
373153004155	Winged helix-turn helix; Region: HTH_33; pfam13592
373153004156	elongation factor Tu; Reviewed; Region: PRK00049
373153004157	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
373153004158	G1 box; other site
373153004159	GEF interaction site [polypeptide binding]; other site
373153004160	GTP/Mg2+ binding site [chemical binding]; other site
373153004161	Switch I region; other site
373153004162	G2 box; other site
373153004163	G3 box; other site
373153004164	Switch II region; other site
373153004165	G4 box; other site
373153004166	G5 box; other site
373153004167	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
373153004168	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
373153004169	Antibiotic Binding Site [chemical binding]; other site
373153004170	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
373153004171	amphipathic channel; other site
373153004172	Asn-Pro-Ala signature motifs; other site
373153004173	MucBP domain; Region: MucBP; pfam06458
373153004174	DDE superfamily endonuclease; Region: DDE_3; pfam13358
373153004175	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
373153004176	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
373153004177	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
373153004178	active site
373153004179	substrate binding site [chemical binding]; other site
373153004180	metal binding site [ion binding]; metal-binding site
373153004181	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
373153004182	catalytic residues [active]
373153004183	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
373153004184	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
373153004185	substrate binding pocket [chemical binding]; other site
373153004186	membrane-bound complex binding site; other site
373153004187	hinge residues; other site
373153004188	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
373153004189	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
373153004190	Walker A/P-loop; other site
373153004191	ATP binding site [chemical binding]; other site
373153004192	Q-loop/lid; other site
373153004193	ABC transporter signature motif; other site
373153004194	Walker B; other site
373153004195	D-loop; other site
373153004196	H-loop/switch region; other site
373153004197	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
373153004198	dimer interface [polypeptide binding]; other site
373153004199	conserved gate region; other site
373153004200	putative PBP binding loops; other site
373153004201	ABC-ATPase subunit interface; other site
373153004202	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
373153004203	TPR motif; other site
373153004204	binding surface
373153004205	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
373153004206	binding surface
373153004207	TPR motif; other site
373153004208	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
373153004209	Domain of unknown function DUF20; Region: UPF0118; pfam01594
373153004210	3-carboxymuconate cyclase [Carbohydrate transport and metabolism]; Region: COG2706
373153004211	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
373153004212	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
373153004213	gamma subunit interface [polypeptide binding]; other site
373153004214	epsilon subunit interface [polypeptide binding]; other site
373153004215	LBP interface [polypeptide binding]; other site
373153004216	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
373153004217	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
373153004218	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
373153004219	alpha subunit interaction interface [polypeptide binding]; other site
373153004220	Walker A motif; other site
373153004221	ATP binding site [chemical binding]; other site
373153004222	Walker B motif; other site
373153004223	inhibitor binding site; inhibition site
373153004224	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
373153004225	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
373153004226	core domain interface [polypeptide binding]; other site
373153004227	delta subunit interface [polypeptide binding]; other site
373153004228	epsilon subunit interface [polypeptide binding]; other site
373153004229	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
373153004230	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
373153004231	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
373153004232	beta subunit interaction interface [polypeptide binding]; other site
373153004233	Walker A motif; other site
373153004234	ATP binding site [chemical binding]; other site
373153004235	Walker B motif; other site
373153004236	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
373153004237	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
373153004238	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
373153004239	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
373153004240	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
373153004241	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
373153004242	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
373153004243	F0F1 ATP synthase subunit C; Provisional; Region: PRK13467
373153004244	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
373153004245	Helix-turn-helix domain; Region: HTH_38; pfam13936
373153004246	Integrase core domain; Region: rve; pfam00665
373153004247	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
373153004248	Coenzyme A binding pocket [chemical binding]; other site
373153004249	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
373153004250	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
373153004251	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
373153004252	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
373153004253	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
373153004254	dimerization interface [polypeptide binding]; other site
373153004255	Acetyltransferase (GNAT) domain; Region: Acetyltransf_4; pfam13420
373153004256	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
373153004257	Coenzyme A binding pocket [chemical binding]; other site
373153004258	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
373153004259	Coenzyme A binding pocket [chemical binding]; other site
373153004260	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
373153004261	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
373153004262	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
373153004263	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
373153004264	Bacterial SNF2 helicase associated; Region: SNF2_assoc; pfam08455
373153004265	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
373153004266	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
373153004267	ATP binding site [chemical binding]; other site
373153004268	putative Mg++ binding site [ion binding]; other site
373153004269	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
373153004270	nucleotide binding region [chemical binding]; other site
373153004271	ATP-binding site [chemical binding]; other site
373153004272	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
373153004273	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
373153004274	pyridoxal 5'-phosphate binding site [chemical binding]; other site
373153004275	homodimer interface [polypeptide binding]; other site
373153004276	catalytic residue [active]
373153004277	cystathionine gamma-synthase; Reviewed; Region: PRK07269
373153004278	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
373153004279	homodimer interface [polypeptide binding]; other site
373153004280	substrate-cofactor binding pocket; other site
373153004281	pyridoxal 5'-phosphate binding site [chemical binding]; other site
373153004282	catalytic residue [active]
373153004283	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
373153004284	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
373153004285	H-loop/switch region; other site
373153004286	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
373153004287	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
373153004288	Walker A/P-loop; other site
373153004289	ATP binding site [chemical binding]; other site
373153004290	Q-loop/lid; other site
373153004291	ABC transporter signature motif; other site
373153004292	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
373153004293	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
373153004294	peptide binding site [polypeptide binding]; other site
373153004295	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
373153004296	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
373153004297	UDP-N-acetylmuramoylalanyl-D-glutamate--L-lysine ligase; Provisional; Region: PRK14022
373153004298	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
373153004299	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
373153004300	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
373153004301	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3237
373153004302	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
373153004303	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
373153004304	DHH family; Region: DHH; pfam01368
373153004305	DHHA2 domain; Region: DHHA2; pfam02833
373153004306	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
373153004307	GIY-YIG motif/motif A; other site
373153004308	putative active site [active]
373153004309	putative metal binding site [ion binding]; other site
373153004310	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
373153004311	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
373153004312	S-adenosylmethionine binding site [chemical binding]; other site
373153004313	hypothetical protein; Provisional; Region: PRK07252
373153004314	Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098
373153004315	RNA binding site [nucleotide binding]; other site
373153004316	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
373153004317	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
373153004318	active site
373153004319	motif I; other site
373153004320	motif II; other site
373153004321	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
373153004322	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
373153004323	active site
373153004324	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
373153004325	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
373153004326	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
373153004327	dimer interface [polypeptide binding]; other site
373153004328	ssDNA binding site [nucleotide binding]; other site
373153004329	tetramer (dimer of dimers) interface [polypeptide binding]; other site
373153004330	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
373153004331	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
373153004332	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
373153004333	putative dimer interface [polypeptide binding]; other site
373153004334	putative anticodon binding site; other site
373153004335	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
373153004336	homodimer interface [polypeptide binding]; other site
373153004337	motif 1; other site
373153004338	motif 2; other site
373153004339	active site
373153004340	motif 3; other site
373153004341	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
373153004342	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
373153004343	aspartate aminotransferase; Provisional; Region: PRK05764
373153004344	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
373153004345	pyridoxal 5'-phosphate binding site [chemical binding]; other site
373153004346	homodimer interface [polypeptide binding]; other site
373153004347	catalytic residue [active]
373153004348	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353
373153004349	Predicted flavoprotein [General function prediction only]; Region: COG0431
373153004350	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
373153004351	G5 domain; Region: G5; pfam07501
373153004352	Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
373153004353	Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
373153004354	Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
373153004355	Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
373153004356	Streptococcal surface-anchored protein repeat, S. criceti family; Region: RPT_S_cricet; TIGR04203
373153004357	Streptococcal surface-anchored protein repeat, S. criceti family; Region: RPT_S_cricet; TIGR04203
373153004358	Streptococcal surface-anchored protein repeat, S. criceti family; Region: RPT_S_cricet; TIGR04203
373153004359	Collagen triple helix repeat (20 copies); Region: Collagen; pfam01391
373153004360	Streptococcal surface-anchored protein repeat, S. criceti family; Region: RPT_S_cricet; TIGR04203
373153004361	Streptococcal surface-anchored protein repeat, S. criceti family; Region: RPT_S_cricet; TIGR04203
373153004362	Streptococcal surface-anchored protein repeat, S. criceti family; Region: RPT_S_cricet; TIGR04203
373153004363	Streptococcal surface-anchored protein repeat, S. criceti family; Region: RPT_S_cricet; TIGR04203
373153004364	Streptococcal surface-anchored protein repeat, S. criceti family; Region: RPT_S_cricet; TIGR04203
373153004365	Streptococcal surface-anchored protein repeat, S. criceti family; Region: RPT_S_cricet; TIGR04203
373153004366	M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280
373153004367	Mga helix-turn-helix domain; Region: Mga; pfam05043
373153004368	M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270
373153004369	hypothetical protein; Validated; Region: PRK02101
373153004370	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
373153004371	active site
373153004372	catalytic residues [active]
373153004373	metal binding site [ion binding]; metal-binding site
373153004374	putative S-transferase; Provisional; Region: PRK11752
373153004375	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
373153004376	C-terminal domain interface [polypeptide binding]; other site
373153004377	GSH binding site (G-site) [chemical binding]; other site
373153004378	dimer interface [polypeptide binding]; other site
373153004379	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
373153004380	N-terminal domain interface [polypeptide binding]; other site
373153004381	dimer interface [polypeptide binding]; other site
373153004382	substrate binding pocket (H-site) [chemical binding]; other site
373153004383	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
373153004384	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
373153004385	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
373153004386	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
373153004387	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
373153004388	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
373153004389	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
373153004390	Cation efflux family; Region: Cation_efflux; pfam01545
373153004391	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4994
373153004392	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
373153004393	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
373153004394	Walker A/P-loop; other site
373153004395	ATP binding site [chemical binding]; other site
373153004396	Q-loop/lid; other site
373153004397	ABC transporter signature motif; other site
373153004398	Walker B; other site
373153004399	D-loop; other site
373153004400	H-loop/switch region; other site
373153004401	ABC transporter; Region: ABC_tran_2; pfam12848
373153004402	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
373153004403	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
373153004404	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
373153004405	active site
373153004406	NTP binding site [chemical binding]; other site
373153004407	metal binding triad [ion binding]; metal-binding site
373153004408	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
373153004409	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
373153004410	dihydrodipicolinate reductase; Provisional; Region: PRK00048
373153004411	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
373153004412	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
373153004413	EDD domain protein, DegV family; Region: DegV; TIGR00762
373153004414	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
373153004415	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4835
373153004416	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
373153004417	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
373153004418	active site
373153004419	substrate binding site [chemical binding]; other site
373153004420	metal binding site [ion binding]; metal-binding site
373153004421	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
373153004422	YbbR-like protein; Region: YbbR; pfam07949
373153004423	Uncharacterized conserved protein [Function unknown]; Region: COG1624
373153004424	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
373153004425	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
373153004426	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
373153004427	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
373153004428	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
373153004429	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
373153004430	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
373153004431	Family of CofD-like proteins and proteins related to YvcK; Region: CofD_YvcK; cd07044
373153004432	dimer interface [polypeptide binding]; other site
373153004433	phosphate binding site [ion binding]; other site
373153004434	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
373153004435	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
373153004436	homotrimer interaction site [polypeptide binding]; other site
373153004437	putative active site [active]
373153004438	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
373153004439	G1 box; other site
373153004440	GTP/Mg2+ binding site [chemical binding]; other site
373153004441	Switch I region; other site
373153004442	G2 box; other site
373153004443	G3 box; other site
373153004444	Switch II region; other site
373153004445	G4 box; other site
373153004446	G5 box; other site
373153004447	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
373153004448	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
373153004449	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
373153004450	Walker A motif; other site
373153004451	ATP binding site [chemical binding]; other site
373153004452	Walker B motif; other site
373153004453	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
373153004454	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
373153004455	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
373153004456	folate binding site [chemical binding]; other site
373153004457	NADP+ binding site [chemical binding]; other site
373153004458	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
373153004459	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
373153004460	dimerization interface [polypeptide binding]; other site
373153004461	DPS ferroxidase diiron center [ion binding]; other site
373153004462	ion pore; other site
373153004463	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
373153004464	Protein of unknown function (DUF1007); Region: DUF1007; cl01487
373153004465	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
373153004466	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
373153004467	active site
373153004468	triosephosphate isomerase; Provisional; Region: PRK14567
373153004469	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
373153004470	substrate binding site [chemical binding]; other site
373153004471	dimer interface [polypeptide binding]; other site
373153004472	catalytic triad [active]
373153004473	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
373153004474	DnaD and phage-associated domain; Region: DnaD_dom; TIGR01446
373153004475	Homoserine trans-succinylase [Amino acid transport and metabolism]; Region: MetA; COG1897
373153004476	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
373153004477	proposed active site lysine [active]
373153004478	conserved cys residue [active]
373153004479	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
373153004480	active site
373153004481	Methyltransferase domain; Region: Methyltransf_31; pfam13847
373153004482	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
373153004483	S-adenosylmethionine binding site [chemical binding]; other site
373153004484	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
373153004485	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
373153004486	Walker A/P-loop; other site
373153004487	ATP binding site [chemical binding]; other site
373153004488	Q-loop/lid; other site
373153004489	ABC transporter signature motif; other site
373153004490	Walker B; other site
373153004491	D-loop; other site
373153004492	H-loop/switch region; other site
373153004493	TOBE domain; Region: TOBE_2; pfam08402
373153004494	Isochorismatase family; Region: Isochorismatase; pfam00857
373153004495	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
373153004496	catalytic triad [active]
373153004497	conserved cis-peptide bond; other site
373153004498	Pleiotropic transcriptional repressor [Transcription]; Region: CodY; COG4465
373153004499	CodY GAF-like domain; Region: CodY; pfam06018
373153004500	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
373153004501	putative DNA binding site [nucleotide binding]; other site
373153004502	putative Zn2+ binding site [ion binding]; other site
373153004503	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
373153004504	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
373153004505	ATP binding site [chemical binding]; other site
373153004506	Mg++ binding site [ion binding]; other site
373153004507	motif III; other site
373153004508	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
373153004509	nucleotide binding region [chemical binding]; other site
373153004510	ATP-binding site [chemical binding]; other site
373153004511	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
373153004512	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
373153004513	putative substrate translocation pore; other site
373153004514	pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251
373153004515	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
373153004516	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
373153004517	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
373153004518	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
373153004519	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
373153004520	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
373153004521	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
373153004522	catalytic triad [active]
373153004523	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
373153004524	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
373153004525	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
373153004526	active site
373153004527	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
373153004528	Predicted membrane protein [Function unknown]; Region: COG4720
373153004529	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
373153004530	dimer interface [polypeptide binding]; other site
373153004531	substrate binding site [chemical binding]; other site
373153004532	ATP binding site [chemical binding]; other site
373153004533	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
373153004534	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
373153004535	dimerization interface 3.5A [polypeptide binding]; other site
373153004536	active site
373153004537	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
373153004538	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
373153004539	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
373153004540	PhnA protein; Region: PhnA; pfam03831
373153004541	cytidylate kinase; Provisional; Region: cmk; PRK00023
373153004542	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
373153004543	CMP-binding site; other site
373153004544	The sites determining sugar specificity; other site
373153004545	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
373153004546	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
373153004547	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
373153004548	Ligand binding site; other site
373153004549	Putative Catalytic site; other site
373153004550	DXD motif; other site
373153004551	UDP-glucose 4-epimerase; Region: PLN02240
373153004552	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
373153004553	NAD binding site [chemical binding]; other site
373153004554	homodimer interface [polypeptide binding]; other site
373153004555	active site
373153004556	substrate binding site [chemical binding]; other site
373153004557	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
373153004558	Uncharacterized conserved protein [Function unknown]; Region: COG0327
373153004559	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
373153004560	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
373153004561	Family of unknown function (DUF633); Region: DUF633; pfam04816
373153004562	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
373153004563	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
373153004564	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
373153004565	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
373153004566	motif II; other site
373153004567	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
373153004568	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
373153004569	putative acyl-acceptor binding pocket; other site
373153004570	Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300
373153004571	Cadmium resistance transporter; Region: Cad; pfam03596
373153004572	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
373153004573	16S/18S rRNA binding site [nucleotide binding]; other site
373153004574	S13e-L30e interaction site [polypeptide binding]; other site
373153004575	25S rRNA binding site [nucleotide binding]; other site
373153004576	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
373153004577	NADH(P)-binding; Region: NAD_binding_10; pfam13460
373153004578	NAD binding site [chemical binding]; other site
373153004579	substrate binding site [chemical binding]; other site
373153004580	putative active site [active]
373153004581	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
373153004582	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941
373153004583	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
373153004584	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
373153004585	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
373153004586	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
373153004587	active site
373153004588	dimer interface [polypeptide binding]; other site
373153004589	motif 1; other site
373153004590	motif 2; other site
373153004591	motif 3; other site
373153004592	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
373153004593	anticodon binding site; other site
373153004594	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
373153004595	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
373153004596	ATP binding site [chemical binding]; other site
373153004597	Mg2+ binding site [ion binding]; other site
373153004598	G-X-G motif; other site
373153004599	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
373153004600	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
373153004601	active site
373153004602	phosphorylation site [posttranslational modification]
373153004603	intermolecular recognition site; other site
373153004604	dimerization interface [polypeptide binding]; other site
373153004605	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
373153004606	DNA binding site [nucleotide binding]
373153004607	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741
373153004608	nucleophilic elbow; other site
373153004609	catalytic triad; other site
373153004610	Predicted transcriptional regulator [Transcription]; Region: COG1959
373153004611	Transcriptional regulator; Region: Rrf2; pfam02082
373153004612	Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850
373153004613	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
373153004614	active site
373153004615	metal binding site [ion binding]; metal-binding site
373153004616	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
373153004617	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
373153004618	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
373153004619	FeoA domain; Region: FeoA; pfam04023
373153004620	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
373153004621	putative active site [active]
373153004622	dimerization interface [polypeptide binding]; other site
373153004623	putative tRNAtyr binding site [nucleotide binding]; other site
373153004624	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
373153004625	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
373153004626	Zn2+ binding site [ion binding]; other site
373153004627	Mg2+ binding site [ion binding]; other site
373153004628	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
373153004629	synthetase active site [active]
373153004630	NTP binding site [chemical binding]; other site
373153004631	metal binding site [ion binding]; metal-binding site
373153004632	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
373153004633	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
373153004634	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
373153004635	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
373153004636	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
373153004637	active site
373153004638	Zn binding site [ion binding]; other site
373153004639	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
373153004640	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
373153004641	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
373153004642	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
373153004643	ABC-ATPase subunit  interface; other site
373153004644	dimer interface [polypeptide binding]; other site
373153004645	putative PBP binding regions; other site
373153004646	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
373153004647	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
373153004648	metal binding site [ion binding]; metal-binding site
373153004649	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
373153004650	dimer interface [polypeptide binding]; other site
373153004651	catalytic triad [active]
373153004652	peroxidatic and resolving cysteines [active]
373153004653	FtsX-like permease family; Region: FtsX; pfam02687
373153004654	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
373153004655	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
373153004656	FtsX-like permease family; Region: FtsX; pfam02687
373153004657	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
373153004658	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
373153004659	Walker A/P-loop; other site
373153004660	ATP binding site [chemical binding]; other site
373153004661	Q-loop/lid; other site
373153004662	ABC transporter signature motif; other site
373153004663	Walker B; other site
373153004664	D-loop; other site
373153004665	H-loop/switch region; other site
373153004666	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
373153004667	catalytic core [active]
373153004668	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
373153004669	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
373153004670	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
373153004671	active site
373153004672	HIGH motif; other site
373153004673	nucleotide binding site [chemical binding]; other site
373153004674	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
373153004675	active site
373153004676	KMSKS motif; other site
373153004677	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
373153004678	tRNA binding surface [nucleotide binding]; other site
373153004679	anticodon binding site; other site
373153004680	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
373153004681	DivIVA domain; Region: DivI1A_domain; TIGR03544
373153004682	Cell division initiation protein [Cell division and chromosome partitioning]; Region: DivIVA; COG3599
373153004683	The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual proteins of this...; Region: Band_7; cl02525
373153004684	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
373153004685	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
373153004686	RNA binding surface [nucleotide binding]; other site
373153004687	YGGT family; Region: YGGT; pfam02325
373153004688	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1799
373153004689	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
373153004690	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
373153004691	catalytic residue [active]
373153004692	cell division protein FtsZ; Validated; Region: PRK09330
373153004693	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
373153004694	nucleotide binding site [chemical binding]; other site
373153004695	SulA interaction site; other site
373153004696	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
373153004697	Cell division protein FtsA; Region: FtsA; smart00842
373153004698	Cell division protein FtsA; Region: FtsA; pfam14450
373153004699	Domain of unknown function (DUF3484); Region: DUF3484; pfam11983
373153004700	Integral membrane protein (intg_mem_TP0381); Region: Intg_mem_TP0381; pfam09529
373153004701	Hydrolase of X-linked nucleoside diphosphate N terminal; Region: Nudix_N; pfam12535
373153004702	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_14; cd04672
373153004703	nudix motif; other site
373153004704	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
373153004705	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
373153004706	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
373153004707	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
373153004708	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
373153004709	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
373153004710	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
373153004711	recombination protein RecR; Reviewed; Region: recR; PRK00076
373153004712	RecR protein; Region: RecR; pfam02132
373153004713	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
373153004714	putative active site [active]
373153004715	putative metal-binding site [ion binding]; other site
373153004716	tetramer interface [polypeptide binding]; other site
373153004717	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
373153004718	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
373153004719	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
373153004720	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
373153004721	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
373153004722	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
373153004723	putative active site [active]
373153004724	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
373153004725	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
373153004726	nucleotide binding site [chemical binding]; other site
373153004727	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
373153004728	Class I aldolases; Region: Aldolase_Class_I; cl17187
373153004729	catalytic residue [active]
373153004730	Protein of unknown function, DUF624; Region: DUF624; pfam04854
373153004731	Domain of unknown function (DUF386); Region: DUF386; pfam04074
373153004732	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
373153004733	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
373153004734	dimer interface [polypeptide binding]; other site
373153004735	conserved gate region; other site
373153004736	putative PBP binding loops; other site
373153004737	ABC-ATPase subunit interface; other site
373153004738	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
373153004739	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
373153004740	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
373153004741	putative PBP binding loops; other site
373153004742	dimer interface [polypeptide binding]; other site
373153004743	ABC-ATPase subunit interface; other site
373153004744	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
373153004745	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
373153004746	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
373153004747	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
373153004748	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
373153004749	active site turn [active]
373153004750	phosphorylation site [posttranslational modification]
373153004751	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
373153004752	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
373153004753	putative active site cavity [active]
373153004754	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
373153004755	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
373153004756	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
373153004757	Neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: NanH; COG4409
373153004758	Sialidase, N-terminal domain; Region: Sialidase; pfam02973
373153004759	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
373153004760	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
373153004761	Asp-box motif; other site
373153004762	catalytic site [active]
373153004763	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
373153004764	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
373153004765	dimer interface [polypeptide binding]; other site
373153004766	conserved gate region; other site
373153004767	putative PBP binding loops; other site
373153004768	ABC-ATPase subunit interface; other site
373153004769	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
373153004770	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
373153004771	dimer interface [polypeptide binding]; other site
373153004772	conserved gate region; other site
373153004773	putative PBP binding loops; other site
373153004774	ABC-ATPase subunit interface; other site
373153004775	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
373153004776	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
373153004777	uncharacterized protein, YhcH/YjgK/YiaL family; Region: TIGR00022
373153004778	Sialidase, N-terminal domain; Region: Sialidase; pfam02973
373153004779	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
373153004780	catalytic site [active]
373153004781	Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260
373153004782	Asp-box motif; other site
373153004783	Asp-box motif; other site
373153004784	catalytic site [active]
373153004785	Procyclic acidic repetitive protein (PARP); Region: Trypan_PARP; pfam05887
373153004786	Acetyl xylan esterase (AXE1); Region: AXE1; pfam05448
373153004787	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
373153004788	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
373153004789	ssDNA binding site; other site
373153004790	generic binding surface II; other site
373153004791	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
373153004792	ATP binding site [chemical binding]; other site
373153004793	putative Mg++ binding site [ion binding]; other site
373153004794	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
373153004795	nucleotide binding region [chemical binding]; other site
373153004796	ATP-binding site [chemical binding]; other site
373153004797	alanine racemase; Reviewed; Region: alr; PRK00053
373153004798	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
373153004799	active site
373153004800	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
373153004801	dimer interface [polypeptide binding]; other site
373153004802	substrate binding site [chemical binding]; other site
373153004803	catalytic residues [active]
373153004804	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
373153004805	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG0722
373153004806	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
373153004807	3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; COG0722
373153004808	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
373153004809	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
373153004810	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
373153004811	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
373153004812	nucleotide binding region [chemical binding]; other site
373153004813	ATP-binding site [chemical binding]; other site
373153004814	SEC-C motif; Region: SEC-C; pfam02810
373153004815	gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740
373153004816	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
373153004817	Walker A/P-loop; other site
373153004818	ATP binding site [chemical binding]; other site
373153004819	Q-loop/lid; other site
373153004820	ABC transporter signature motif; other site
373153004821	Walker B; other site
373153004822	D-loop; other site
373153004823	H-loop/switch region; other site
373153004824	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
373153004825	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
373153004826	non-specific DNA binding site [nucleotide binding]; other site
373153004827	salt bridge; other site
373153004828	sequence-specific DNA binding site [nucleotide binding]; other site
373153004829	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
373153004830	GTP-binding protein Der; Reviewed; Region: PRK00093
373153004831	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
373153004832	G1 box; other site
373153004833	GTP/Mg2+ binding site [chemical binding]; other site
373153004834	Switch I region; other site
373153004835	G2 box; other site
373153004836	Switch II region; other site
373153004837	G3 box; other site
373153004838	G4 box; other site
373153004839	G5 box; other site
373153004840	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
373153004841	G1 box; other site
373153004842	GTP/Mg2+ binding site [chemical binding]; other site
373153004843	Switch I region; other site
373153004844	G2 box; other site
373153004845	G3 box; other site
373153004846	Switch II region; other site
373153004847	G4 box; other site
373153004848	G5 box; other site
373153004849	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
373153004850	dimer interface [polypeptide binding]; other site
373153004851	FMN binding site [chemical binding]; other site
373153004852	NADPH bind site [chemical binding]; other site
373153004853	primosomal protein DnaI; Reviewed; Region: PRK08939
373153004854	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
373153004855	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
373153004856	Walker A motif; other site
373153004857	ATP binding site [chemical binding]; other site
373153004858	Walker B motif; other site
373153004859	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
373153004860	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
373153004861	ATP cone domain; Region: ATP-cone; pfam03477
373153004862	Predicted transcriptional regulators [Transcription]; Region: COG1725
373153004863	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
373153004864	DNA-binding site [nucleotide binding]; DNA binding site
373153004865	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
373153004866	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
373153004867	Walker A/P-loop; other site
373153004868	ATP binding site [chemical binding]; other site
373153004869	Q-loop/lid; other site
373153004870	ABC transporter signature motif; other site
373153004871	Walker B; other site
373153004872	D-loop; other site
373153004873	H-loop/switch region; other site
373153004874	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
373153004875	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
373153004876	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
373153004877	Walker A/P-loop; other site
373153004878	ATP binding site [chemical binding]; other site
373153004879	Q-loop/lid; other site
373153004880	ABC transporter signature motif; other site
373153004881	Walker B; other site
373153004882	D-loop; other site
373153004883	H-loop/switch region; other site
373153004884	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
373153004885	Uncharacterized conserved protein [Function unknown]; Region: COG0398
373153004886	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
373153004887	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
373153004888	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
373153004889	nucleotide binding site [chemical binding]; other site
373153004890	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
373153004891	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
373153004892	active site turn [active]
373153004893	phosphorylation site [posttranslational modification]
373153004894	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
373153004895	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
373153004896	HPr interaction site; other site
373153004897	glycerol kinase (GK) interaction site [polypeptide binding]; other site
373153004898	active site
373153004899	phosphorylation site [posttranslational modification]
373153004900	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
373153004901	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
373153004902	substrate binding [chemical binding]; other site
373153004903	active site
373153004904	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
373153004905	Transcriptional regulators [Transcription]; Region: PurR; COG1609
373153004906	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
373153004907	DNA binding site [nucleotide binding]
373153004908	domain linker motif; other site
373153004909	Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291
373153004910	dimerization interface [polypeptide binding]; other site
373153004911	ligand binding site [chemical binding]; other site
373153004912	sodium binding site [ion binding]; other site
373153004913	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
373153004914	homodimer interface [polypeptide binding]; other site
373153004915	catalytic residues [active]
373153004916	NAD binding site [chemical binding]; other site
373153004917	substrate binding pocket [chemical binding]; other site
373153004918	flexible flap; other site
373153004919	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
373153004920	3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835
373153004921	dimer interface [polypeptide binding]; other site
373153004922	active site
373153004923	Uncharacterized conserved protein [Function unknown]; Region: COG3610
373153004924	Uncharacterized conserved protein [Function unknown]; Region: COG2966
373153004925	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
373153004926	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
373153004927	Catalytic domain of Protein Kinases; Region: PKc; cd00180
373153004928	active site
373153004929	ATP binding site [chemical binding]; other site
373153004930	substrate binding site [chemical binding]; other site
373153004931	activation loop (A-loop); other site
373153004932	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
373153004933	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
373153004934	PASTA domain; Region: PASTA; smart00740
373153004935	PASTA domain; Region: PASTA; smart00740
373153004936	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
373153004937	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
373153004938	active site
373153004939	16S rRNA methyltransferase B; Provisional; Region: PRK14902
373153004940	NusB family; Region: NusB; pfam01029
373153004941	putative RNA binding site [nucleotide binding]; other site
373153004942	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
373153004943	S-adenosylmethionine binding site [chemical binding]; other site
373153004944	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
373153004945	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
373153004946	putative active site [active]
373153004947	substrate binding site [chemical binding]; other site
373153004948	putative cosubstrate binding site; other site
373153004949	catalytic site [active]
373153004950	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
373153004951	substrate binding site [chemical binding]; other site
373153004952	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
373153004953	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
373153004954	ATP binding site [chemical binding]; other site
373153004955	putative Mg++ binding site [ion binding]; other site
373153004956	helicase superfamily c-terminal domain; Region: HELICc; smart00490
373153004957	ATP-binding site [chemical binding]; other site
373153004958	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
373153004959	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
373153004960	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
373153004961	catalytic site [active]
373153004962	G-X2-G-X-G-K; other site
373153004963	hypothetical protein; Provisional; Region: PRK00106
373153004964	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
373153004965	Zn2+ binding site [ion binding]; other site
373153004966	Mg2+ binding site [ion binding]; other site
373153004967	Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769
373153004968	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
373153004969	hypothetical protein; Provisional; Region: PRK13670
373153004970	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; pfam05636
373153004971	SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500
373153004972	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
373153004973	S-adenosylmethionine binding site [chemical binding]; other site
373153004974	Uncharacterized homolog of plant Iojap protein [Function unknown]; Region: COG0799
373153004975	Isochorismatase family; Region: Isochorismatase; pfam00857
373153004976	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
373153004977	catalytic triad [active]
373153004978	conserved cis-peptide bond; other site
373153004979	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
373153004980	Zn2+ binding site [ion binding]; other site
373153004981	Mg2+ binding site [ion binding]; other site
373153004982	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
373153004983	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
373153004984	active site
373153004985	(T/H)XGH motif; other site
373153004986	Predicted RNA-binding protein containing KH domain, possibly ribosomal protein [Translation, ribosomal structure and biogenesis]; Region: COG1534
373153004987	GTPase YqeH; Provisional; Region: PRK13796
373153004988	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
373153004989	GTP/Mg2+ binding site [chemical binding]; other site
373153004990	G4 box; other site
373153004991	G5 box; other site
373153004992	G1 box; other site
373153004993	Switch I region; other site
373153004994	G2 box; other site
373153004995	G3 box; other site
373153004996	Switch II region; other site
373153004997	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
373153004998	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
373153004999	active site
373153005000	motif I; other site
373153005001	motif II; other site
373153005002	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
373153005003	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
373153005004	Cl binding site [ion binding]; other site
373153005005	oligomer interface [polypeptide binding]; other site
373153005006	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
373153005007	Mechanosensitive ion channel; Region: MS_channel; pfam00924
373153005008	serine/threonine transporter SstT; Provisional; Region: PRK14695
373153005009	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
373153005010	Predicted membrane protein [Function unknown]; Region: COG4129
373153005011	Bacterial protein of unknown function (DUF939); Region: DUF939; pfam06081
373153005012	DUF939 C-terminal domain; Region: DUF939_C; pfam11728
373153005013	MarR family; Region: MarR; pfam01047
373153005014	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
373153005015	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
373153005016	catalytic residues [active]
373153005017	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
373153005018	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
373153005019	amphipathic channel; other site
373153005020	Asn-Pro-Ala signature motifs; other site
373153005021	Protein of unknown function (DUF2785); Region: DUF2785; pfam10978
373153005022	oligoendopeptidase F; Region: pepF; TIGR00181
373153005023	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
373153005024	Zn binding site [ion binding]; other site
373153005025	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
373153005026	RNA methyltransferase, RsmE family; Region: TIGR00046
373153005027	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
373153005028	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
373153005029	S-adenosylmethionine binding site [chemical binding]; other site
373153005030	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682
373153005031	nudix motif; other site
373153005032	Peptidase family M50; Region: Peptidase_M50; pfam02163
373153005033	Protein of unknown function (DUF3013); Region: DUF3013; pfam11217
373153005034	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
373153005035	recombination factor protein RarA; Reviewed; Region: PRK13342
373153005036	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
373153005037	Walker A motif; other site
373153005038	ATP binding site [chemical binding]; other site
373153005039	Walker B motif; other site
373153005040	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
373153005041	arginine finger; other site
373153005042	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
373153005043	Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621
373153005044	Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996
373153005045	substrate binding [chemical binding]; other site
373153005046	active site
373153005047	Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244
373153005048	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
373153005049	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
373153005050	dimer interface [polypeptide binding]; other site
373153005051	conserved gate region; other site
373153005052	putative PBP binding loops; other site
373153005053	ABC-ATPase subunit interface; other site
373153005054	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
373153005055	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
373153005056	dimer interface [polypeptide binding]; other site
373153005057	conserved gate region; other site
373153005058	putative PBP binding loops; other site
373153005059	ABC-ATPase subunit interface; other site
373153005060	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
373153005061	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
373153005062	Transcriptional regulators [Transcription]; Region: PurR; COG1609
373153005063	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
373153005064	DNA binding site [nucleotide binding]
373153005065	domain linker motif; other site
373153005066	Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291
373153005067	dimerization interface [polypeptide binding]; other site
373153005068	ligand binding site [chemical binding]; other site
373153005069	sodium binding site [ion binding]; other site
373153005070	M protein trans-acting positive regulator (MGA) HTH domain; Region: HTH_Mga; pfam08280
373153005071	Mga helix-turn-helix domain; Region: Mga; pfam05043
373153005072	M protein trans-acting positive regulator (MGA) PRD domain; Region: PRD_Mga; pfam08270
373153005073	Small integral membrane protein [Function unknown]; Region: COG5547
373153005074	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
373153005075	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
373153005076	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
373153005077	Coenzyme A binding pocket [chemical binding]; other site
373153005078	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
373153005079	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
373153005080	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
373153005081	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
373153005082	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
373153005083	non-specific DNA binding site [nucleotide binding]; other site
373153005084	salt bridge; other site
373153005085	sequence-specific DNA binding site [nucleotide binding]; other site
373153005086	Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856
373153005087	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
373153005088	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
373153005089	substrate binding site [chemical binding]; other site
373153005090	active site
373153005091	catalytic residues [active]
373153005092	heterodimer interface [polypeptide binding]; other site
373153005093	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
373153005094	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
373153005095	pyridoxal 5'-phosphate binding site [chemical binding]; other site
373153005096	catalytic residue [active]
373153005097	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
373153005098	active site
373153005099	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
373153005100	active site
373153005101	ribulose/triose binding site [chemical binding]; other site
373153005102	phosphate binding site [ion binding]; other site
373153005103	substrate (anthranilate) binding pocket [chemical binding]; other site
373153005104	product (indole) binding pocket [chemical binding]; other site
373153005105	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
373153005106	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
373153005107	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
373153005108	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
373153005109	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
373153005110	glutamine binding [chemical binding]; other site
373153005111	catalytic triad [active]
373153005112	anthranilate synthase component I; Provisional; Region: PRK13570
373153005113	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
373153005114	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
373153005115	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
373153005116	Transcriptional regulators [Transcription]; Region: PurR; COG1609
373153005117	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
373153005118	DNA binding site [nucleotide binding]
373153005119	domain linker motif; other site
373153005120	Ligand-binding domain of a transcription repressor, FucR, which functions as a molecular sensor of L-fucose availability; Region: PBP1_FucR_like; cd06276
373153005121	putative dimerization interface [polypeptide binding]; other site
373153005122	putative ligand binding site [chemical binding]; other site
373153005123	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
373153005124	MgtC family; Region: MgtC; pfam02308
373153005125	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
373153005126	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
373153005127	dimer interface [polypeptide binding]; other site
373153005128	conserved gate region; other site
373153005129	putative PBP binding loops; other site
373153005130	ABC-ATPase subunit interface; other site
373153005131	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
373153005132	putative PBP binding loops; other site
373153005133	dimer interface [polypeptide binding]; other site
373153005134	ABC-ATPase subunit interface; other site
373153005135	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
373153005136	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
373153005137	Walker A/P-loop; other site
373153005138	ATP binding site [chemical binding]; other site
373153005139	Q-loop/lid; other site
373153005140	ABC transporter signature motif; other site
373153005141	Walker B; other site
373153005142	D-loop; other site
373153005143	H-loop/switch region; other site
373153005144	TOBE domain; Region: TOBE; pfam03459
373153005145	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
373153005146	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
373153005147	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5255
373153005148	Domain of unknown function (DUF1868); Region: 2H-phosphodiest; pfam08975
373153005149	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
373153005150	UDP-glucose 4-epimerase; Region: PLN02240
373153005151	NAD binding site [chemical binding]; other site
373153005152	homodimer interface [polypeptide binding]; other site
373153005153	active site
373153005154	substrate binding site [chemical binding]; other site
373153005155	Galactose-1-phosphate uridyltransferase [Carbohydrate transport and metabolism]; Region: GalT; COG4468
373153005156	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
373153005157	Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744
373153005158	Phosphate uptake regulator [Inorganic ion transport and metabolism]; Region: PhoU; COG0704
373153005159	PhoU domain; Region: PhoU; pfam01895
373153005160	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120
373153005161	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
373153005162	Endopygalactorunase [Cell envelope biogenesis, outer membrane]; Region: PGU1; COG5434
373153005163	Pectate lyase; Region: Pec_lyase_C; cl01593
373153005164	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
373153005165	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
373153005166	inhibitor-cofactor binding pocket; inhibition site
373153005167	pyridoxal 5'-phosphate binding site [chemical binding]; other site
373153005168	catalytic residue [active]
373153005169	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
373153005170	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
373153005171	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
373153005172	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
373153005173	Walker A/P-loop; other site
373153005174	ATP binding site [chemical binding]; other site
373153005175	Q-loop/lid; other site
373153005176	ABC transporter signature motif; other site
373153005177	Walker B; other site
373153005178	D-loop; other site
373153005179	H-loop/switch region; other site
373153005180	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
373153005181	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
373153005182	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
373153005183	Walker A/P-loop; other site
373153005184	ATP binding site [chemical binding]; other site
373153005185	Q-loop/lid; other site
373153005186	ABC transporter signature motif; other site
373153005187	Walker B; other site
373153005188	D-loop; other site
373153005189	H-loop/switch region; other site
373153005190	Predicted membrane protein [Function unknown]; Region: COG2323
373153005191	Protein of unknown function (DUF3290); Region: DUF3290; pfam11694
373153005192	Protein of unknown function (DUF3290); Region: DUF3290; pfam11694
373153005193	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
373153005194	active site
373153005195	putative catalytic site [active]
373153005196	DNA binding site [nucleotide binding]
373153005197	putative phosphate binding site [ion binding]; other site
373153005198	metal binding site A [ion binding]; metal-binding site
373153005199	AP binding site [nucleotide binding]; other site
373153005200	metal binding site B [ion binding]; metal-binding site
373153005201	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
373153005202	active site
373153005203	xanthine permease; Region: pbuX; TIGR03173
373153005204	Sulfate transporter family; Region: Sulfate_transp; pfam00916
373153005205	DpnD/PcfM-like protein; Region: DpnD-PcfM; pfam14207
373153005206	Dam-replacing family; Region: DRP; pfam06044
373153005207	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
373153005208	CoenzymeA binding site [chemical binding]; other site
373153005209	subunit interaction site [polypeptide binding]; other site
373153005210	PHB binding site; other site
373153005211	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270
373153005212	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
373153005213	Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744
373153005214	galactokinase; Provisional; Region: PRK05322
373153005215	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
373153005216	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
373153005217	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
373153005218	DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339
373153005219	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
373153005220	DNA binding site [nucleotide binding]
373153005221	Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544
373153005222	putative dimerization interface [polypeptide binding]; other site
373153005223	putative ligand binding site [chemical binding]; other site
373153005224	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287
373153005225	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
373153005226	catalytic Zn binding site [ion binding]; other site
373153005227	NAD(P) binding site [chemical binding]; other site
373153005228	structural Zn binding site [ion binding]; other site
373153005229	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
373153005230	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
373153005231	DNA binding residues [nucleotide binding]
373153005232	putative dimer interface [polypeptide binding]; other site
373153005233	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
373153005234	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
373153005235	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
373153005236	Utp21 specific WD40 associated putative domain; Region: Utp21; pfam04192
373153005237	nicotinamide mononucleotide transporter PnuC; Region: NMN_trans_PnuC; TIGR01528
373153005238	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
373153005239	dimer interface [polypeptide binding]; other site
373153005240	conserved gate region; other site
373153005241	ABC-ATPase subunit interface; other site
373153005242	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
373153005243	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
373153005244	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
373153005245	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
373153005246	Walker A/P-loop; other site
373153005247	ATP binding site [chemical binding]; other site
373153005248	Q-loop/lid; other site
373153005249	ABC transporter signature motif; other site
373153005250	Walker B; other site
373153005251	D-loop; other site
373153005252	H-loop/switch region; other site
373153005253	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4922
373153005254	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
373153005255	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
373153005256	Enterocin A Immunity; Region: EntA_Immun; pfam08951
373153005257	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
373153005258	M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638
373153005259	oligomer interface [polypeptide binding]; other site
373153005260	active site
373153005261	metal binding site [ion binding]; metal-binding site
373153005262	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
373153005263	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
373153005264	NAD(P) binding site [chemical binding]; other site
373153005265	active site
373153005266	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
373153005267	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
373153005268	ABC-ATPase subunit  interface; other site
373153005269	dimer interface [polypeptide binding]; other site
373153005270	putative PBP binding regions; other site
373153005271	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
373153005272	ABC-ATPase subunit  interface; other site
373153005273	dimer interface [polypeptide binding]; other site
373153005274	putative PBP binding regions; other site
373153005275	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
373153005276	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
373153005277	Walker A/P-loop; other site
373153005278	ATP binding site [chemical binding]; other site
373153005279	Q-loop/lid; other site
373153005280	ABC transporter signature motif; other site
373153005281	Walker B; other site
373153005282	D-loop; other site
373153005283	H-loop/switch region; other site
373153005284	ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607
373153005285	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
373153005286	putative ligand binding residues [chemical binding]; other site
373153005287	hypothetical protein; Validated; Region: PRK00041
373153005288	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
373153005289	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
373153005290	RNA binding surface [nucleotide binding]; other site
373153005291	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
373153005292	active site
373153005293	segregation and condensation protein B; Reviewed; Region: scpB; PRK00135
373153005294	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
373153005295	site-specific tyrosine recombinase XerD-like protein; Reviewed; Region: xerD; PRK02436
373153005296	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
373153005297	DNA binding site [nucleotide binding]
373153005298	Int/Topo IB signature motif; other site
373153005299	active site
373153005300	catalytic residues [active]
373153005301	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_30; cd04643
373153005302	FOG: CBS domain [General function prediction only]; Region: COG0517
373153005303	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
373153005304	active site
373153005305	metal binding site [ion binding]; metal-binding site
373153005306	homotetramer interface [polypeptide binding]; other site
373153005307	putative deoxyribonucleotide triphosphate pyrophosphatase/unknown domain fusion protein; Reviewed; Region: PRK02491
373153005308	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
373153005309	active site
373153005310	dimerization interface [polypeptide binding]; other site
373153005311	glutamate racemase; Provisional; Region: PRK00865
373153005312	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763
373153005313	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
373153005314	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
373153005315	Ca binding site [ion binding]; other site
373153005316	active site
373153005317	catalytic site [active]
373153005318	PTS system, trehalose-specific IIBC component; Region: PTS-IIBC-Tre; TIGR01992
373153005319	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
373153005320	active site turn [active]
373153005321	phosphorylation site [posttranslational modification]
373153005322	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
373153005323	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
373153005324	HPr interaction site; other site
373153005325	glycerol kinase (GK) interaction site [polypeptide binding]; other site
373153005326	active site
373153005327	phosphorylation site [posttranslational modification]
373153005328	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
373153005329	DNA-binding site [nucleotide binding]; DNA binding site
373153005330	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
373153005331	UTRA domain; Region: UTRA; pfam07702
373153005332	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
373153005333	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
373153005334	Walker A/P-loop; other site
373153005335	ATP binding site [chemical binding]; other site
373153005336	Q-loop/lid; other site
373153005337	ABC transporter signature motif; other site
373153005338	Walker B; other site
373153005339	D-loop; other site
373153005340	H-loop/switch region; other site
373153005341	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
373153005342	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
373153005343	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
373153005344	Walker A/P-loop; other site
373153005345	ATP binding site [chemical binding]; other site
373153005346	Q-loop/lid; other site
373153005347	ABC transporter signature motif; other site
373153005348	Walker B; other site
373153005349	D-loop; other site
373153005350	H-loop/switch region; other site
373153005351	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
373153005352	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
373153005353	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
373153005354	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
373153005355	dimer interface [polypeptide binding]; other site
373153005356	conserved gate region; other site
373153005357	putative PBP binding loops; other site
373153005358	ABC-ATPase subunit interface; other site
373153005359	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
373153005360	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
373153005361	dimer interface [polypeptide binding]; other site
373153005362	conserved gate region; other site
373153005363	putative PBP binding loops; other site
373153005364	ABC-ATPase subunit interface; other site
373153005365	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
373153005366	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
373153005367	peptide binding site [polypeptide binding]; other site
373153005368	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
373153005369	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
373153005370	sucrose phosphorylase; Region: sucrose_gtfA; TIGR03852
373153005371	Alpha amylase catalytic domain found in sucrose phosphorylase (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase; cd11355
373153005372	active site
373153005373	homodimer interface [polypeptide binding]; other site
373153005374	catalytic site [active]
373153005375	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
373153005376	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
373153005377	dimer interface [polypeptide binding]; other site
373153005378	conserved gate region; other site
373153005379	putative PBP binding loops; other site
373153005380	ABC-ATPase subunit interface; other site
373153005381	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
373153005382	dimer interface [polypeptide binding]; other site
373153005383	conserved gate region; other site
373153005384	putative PBP binding loops; other site
373153005385	ABC-ATPase subunit interface; other site
373153005386	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
373153005387	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
373153005388	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
373153005389	Melibiase; Region: Melibiase; pfam02065
373153005390	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
373153005391	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
373153005392	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
373153005393	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
373153005394	Biotin operon repressor [Transcription]; Region: BirA; COG1654
373153005395	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
373153005396	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
373153005397	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
373153005398	TRAM domain; Region: TRAM; pfam01938
373153005399	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
373153005400	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
373153005401	S-adenosylmethionine binding site [chemical binding]; other site
373153005402	recombination regulator RecX; Provisional; Region: recX; PRK14135
373153005403	hypothetical protein; Provisional; Region: PRK13662
373153005404	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
373153005405	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
373153005406	Transposase; Region: DDE_Tnp_ISL3; pfam01610
373153005407	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
373153005408	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
373153005409	ring oligomerisation interface [polypeptide binding]; other site
373153005410	ATP/Mg binding site [chemical binding]; other site
373153005411	stacking interactions; other site
373153005412	hinge regions; other site
373153005413	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
373153005414	oligomerisation interface [polypeptide binding]; other site
373153005415	mobile loop; other site
373153005416	roof hairpin; other site
373153005417	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
373153005418	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
373153005419	dimer interface [polypeptide binding]; other site
373153005420	ssDNA binding site [nucleotide binding]; other site
373153005421	tetramer (dimer of dimers) interface [polypeptide binding]; other site
373153005422	classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346
373153005423	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
373153005424	putative NAD(P) binding site [chemical binding]; other site
373153005425	homodimer interface [polypeptide binding]; other site
373153005426	homotetramer interface [polypeptide binding]; other site
373153005427	active site
373153005428	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
373153005429	putative tRNA-binding site [nucleotide binding]; other site
373153005430	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
373153005431	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
373153005432	catalytic residues [active]
373153005433	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
373153005434	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
373153005435	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
373153005436	LytTr DNA-binding domain; Region: LytTR; pfam04397
373153005437	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
373153005438	active site
373153005439	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4898
373153005440	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
373153005441	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
373153005442	Walker A/P-loop; other site
373153005443	ATP binding site [chemical binding]; other site
373153005444	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
373153005445	Walker A/P-loop; other site
373153005446	ATP binding site [chemical binding]; other site
373153005447	Q-loop/lid; other site
373153005448	ABC transporter signature motif; other site
373153005449	Walker B; other site
373153005450	D-loop; other site
373153005451	H-loop/switch region; other site
373153005452	hypothetical protein; Provisional; Region: PRK12378
373153005453	Thiol-activated cytolysin; Region: Thiol_cytolysin; pfam01289
373153005454	Protein of unknown function (DUF4231); Region: DUF4231; pfam14015
373153005455	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
373153005456	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
373153005457	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
373153005458	amidase catalytic site [active]
373153005459	Zn binding residues [ion binding]; other site
373153005460	substrate binding site [chemical binding]; other site
373153005461	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
373153005462	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
373153005463	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
373153005464	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
373153005465	recombinase A; Provisional; Region: recA; PRK09354
373153005466	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
373153005467	hexamer interface [polypeptide binding]; other site
373153005468	Walker A motif; other site
373153005469	ATP binding site [chemical binding]; other site
373153005470	Walker B motif; other site
373153005471	competence damage-inducible protein A; Provisional; Region: PRK00549
373153005472	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
373153005473	putative MPT binding site; other site
373153005474	Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546
373153005475	Transcriptional regulator [Transcription]; Region: LytR; COG1316
373153005476	putative acetyltransferase YhhY; Provisional; Region: PRK10140
373153005477	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
373153005478	Coenzyme A binding pocket [chemical binding]; other site
373153005479	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
373153005480	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
373153005481	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
373153005482	non-specific DNA binding site [nucleotide binding]; other site
373153005483	salt bridge; other site
373153005484	sequence-specific DNA binding site [nucleotide binding]; other site
373153005485	type 2 lantibiotic, SP_1948 family; Region: lant_SP_1948; TIGR03893
373153005486	type 2 lantibiotic, SP_1948 family; Region: lant_SP_1948; TIGR03893
373153005487	Lantibiotic modifying enzyme [Defense mechanisms]; Region: LcnDR2; COG4403
373153005488	LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792
373153005489	active site
373153005490	zinc binding site [ion binding]; other site
373153005491	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
373153005492	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cd05709
373153005493	active site
373153005494	putative substrate binding region [chemical binding]; other site
373153005495	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
373153005496	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39F; cd02425
373153005497	putative active site [active]
373153005498	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
373153005499	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
373153005500	Walker A/P-loop; other site
373153005501	ATP binding site [chemical binding]; other site
373153005502	Q-loop/lid; other site
373153005503	ABC transporter signature motif; other site
373153005504	Walker B; other site
373153005505	D-loop; other site
373153005506	H-loop/switch region; other site
373153005507	Peptidase S8 family domain in Lantiobiotic (lanthionine-containing antibiotics) specific proteases; Region: Peptidases_S8_Lantibiotic_specific_protease; cd07482
373153005508	active site
373153005509	catalytic triad [active]
373153005510	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652
373153005511	Protein of unknown function (DUF1430); Region: DUF1430; pfam07242
373153005512	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
373153005513	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
373153005514	Walker A/P-loop; other site
373153005515	ATP binding site [chemical binding]; other site
373153005516	Q-loop/lid; other site
373153005517	ABC transporter signature motif; other site
373153005518	Walker B; other site
373153005519	D-loop; other site
373153005520	H-loop/switch region; other site
373153005521	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
373153005522	active site
373153005523	multimer interface [polypeptide binding]; other site
373153005524	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
373153005525	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
373153005526	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
373153005527	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
373153005528	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
373153005529	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
373153005530	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
373153005531	G-loop; other site
373153005532	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
373153005533	DNA binding site [nucleotide binding]
373153005534	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
373153005535	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
373153005536	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
373153005537	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
373153005538	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
373153005539	RNA polymerase beta subunit external 1 domain; Region: RNA_pol_Rpb2_45; pfam10385
373153005540	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
373153005541	RPB1 interaction site [polypeptide binding]; other site
373153005542	RPB10 interaction site [polypeptide binding]; other site
373153005543	RPB11 interaction site [polypeptide binding]; other site
373153005544	RPB3 interaction site [polypeptide binding]; other site
373153005545	RPB12 interaction site [polypeptide binding]; other site
373153005546	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
373153005547	Domain of unknown function DUF21; Region: DUF21; pfam01595
373153005548	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
373153005549	Transporter associated domain; Region: CorC_HlyC; smart01091
373153005550	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
373153005551	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; pfam01223
373153005552	DNA-directed RNA polymerase subunit beta; Region: EpuA; pfam11772
373153005553	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
373153005554	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
373153005555	hinge; other site
373153005556	active site
373153005557	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
373153005558	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
373153005559	protein binding site [polypeptide binding]; other site
373153005560	Phosphopantetheine adenylyltransferase [Coenzyme metabolism]; Region: CoaD; COG0669
373153005561	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
373153005562	active site
373153005563	(T/H)XGH motif; other site
373153005564	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
373153005565	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
373153005566	S-adenosylmethionine binding site [chemical binding]; other site
373153005567	Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia.  AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645
373153005568	dimer interface [polypeptide binding]; other site
373153005569	active site
373153005570	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
373153005571	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
373153005572	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
373153005573	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
373153005574	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
373153005575	acylphosphatase; Provisional; Region: PRK14434
373153005576	OxaA-like protein precursor; Provisional; Region: PRK02463
373153005577	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
373153005578	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
373153005579	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
373153005580	FeS/SAM binding site; other site
373153005581	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
373153005582	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
373153005583	active site
373153005584	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
373153005585	substrate binding site [chemical binding]; other site
373153005586	catalytic residues [active]
373153005587	dimer interface [polypeptide binding]; other site
373153005588	pur operon repressor; Provisional; Region: PRK09213
373153005589	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
373153005590	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
373153005591	active site
373153005592	Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481
373153005593	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
373153005594	generic binding surface II; other site
373153005595	generic binding surface I; other site
373153005596	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
373153005597	Zn2+ binding site [ion binding]; other site
373153005598	Mg2+ binding site [ion binding]; other site
373153005599	Predicted nuclease of restriction endonuclease-like fold, RmuC family [General function prediction only]; Region: COG1322
373153005600	RmuC family; Region: RmuC; pfam02646
373153005601	Thiamine pyrophosphokinase [Coenzyme metabolism]; Region: THI80; COG1564
373153005602	Thiamine pyrophosphokinase; Region: TPK; cd07995
373153005603	active site
373153005604	dimerization interface [polypeptide binding]; other site
373153005605	thiamine binding site [chemical binding]; other site
373153005606	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
373153005607	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
373153005608	substrate binding site [chemical binding]; other site
373153005609	hexamer interface [polypeptide binding]; other site
373153005610	metal binding site [ion binding]; metal-binding site
373153005611	GTPase RsgA; Reviewed; Region: PRK00098
373153005612	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
373153005613	RNA binding site [nucleotide binding]; other site
373153005614	homodimer interface [polypeptide binding]; other site
373153005615	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
373153005616	GTPase/Zn-binding domain interface [polypeptide binding]; other site
373153005617	GTP/Mg2+ binding site [chemical binding]; other site
373153005618	G4 box; other site
373153005619	G5 box; other site
373153005620	G1 box; other site
373153005621	Switch I region; other site
373153005622	G2 box; other site
373153005623	G3 box; other site
373153005624	Switch II region; other site
373153005625	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
373153005626	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
373153005627	S-adenosylmethionine binding site [chemical binding]; other site
373153005628	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
373153005629	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
373153005630	Walker A/P-loop; other site
373153005631	ATP binding site [chemical binding]; other site
373153005632	Q-loop/lid; other site
373153005633	ABC transporter signature motif; other site
373153005634	Walker B; other site
373153005635	D-loop; other site
373153005636	H-loop/switch region; other site
373153005637	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4652
373153005638	Protein of unknown function (DUF1430); Region: DUF1430; pfam07242
373153005639	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
373153005640	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
373153005641	non-specific DNA binding site [nucleotide binding]; other site
373153005642	salt bridge; other site
373153005643	sequence-specific DNA binding site [nucleotide binding]; other site
373153005644	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
373153005645	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
373153005646	putative active site [active]
373153005647	putative metal binding site [ion binding]; other site
373153005648	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
373153005649	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
373153005650	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
373153005651	active site
373153005652	Domain of Unknown Function (DUF1542); Region: DUF1542; pfam07564
373153005653	Ribosomal protein L34; Region: Ribosomal_L34; cl00370
373153005654	aminotransferase AlaT; Validated; Region: PRK09265
373153005655	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
373153005656	pyridoxal 5'-phosphate binding site [chemical binding]; other site
373153005657	homodimer interface [polypeptide binding]; other site
373153005658	catalytic residue [active]
373153005659	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
373153005660	Ligand Binding Site [chemical binding]; other site
373153005661	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
373153005662	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
373153005663	active site
373153005664	motif I; other site
373153005665	motif II; other site
373153005666	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
373153005667	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Exiguobacterium sibiricum YP_001813558.1 protein and its bacterial homologs; Region: NTP-PPase_YP_001813558; cd11545
373153005668	putative nucleotide binding site [chemical binding]; other site
373153005669	putative metal binding site [ion binding]; other site
373153005670	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
373153005671	active site
373153005672	homotetramer interface [polypeptide binding]; other site
373153005673	homodimer interface [polypeptide binding]; other site
373153005674	catabolite control protein A; Region: ccpA; TIGR01481
373153005675	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
373153005676	DNA binding site [nucleotide binding]
373153005677	domain linker motif; other site
373153005678	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
373153005679	dimerization interface [polypeptide binding]; other site
373153005680	effector binding site; other site
373153005681	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
373153005682	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
373153005683	active site
373153005684	phosphorylation site [posttranslational modification]
373153005685	intermolecular recognition site; other site
373153005686	dimerization interface [polypeptide binding]; other site
373153005687	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
373153005688	DNA binding residues [nucleotide binding]
373153005689	dimerization interface [polypeptide binding]; other site
373153005690	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
373153005691	Histidine kinase; Region: HisKA_3; pfam07730
373153005692	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
373153005693	ATP binding site [chemical binding]; other site
373153005694	Mg2+ binding site [ion binding]; other site
373153005695	G-X-G motif; other site
373153005696	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
373153005697	ABC-2 type transporter; Region: ABC2_membrane; cl17235
373153005698	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
373153005699	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
373153005700	Walker A/P-loop; other site
373153005701	ATP binding site [chemical binding]; other site
373153005702	Q-loop/lid; other site
373153005703	ABC transporter signature motif; other site
373153005704	Walker B; other site
373153005705	D-loop; other site
373153005706	H-loop/switch region; other site
373153005707	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
373153005708	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
373153005709	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
373153005710	putative homodimer interface [polypeptide binding]; other site
373153005711	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
373153005712	heterodimer interface [polypeptide binding]; other site
373153005713	homodimer interface [polypeptide binding]; other site
373153005714	Preprotein translocase subunit SecE [Intracellular trafficking and secretion]; Region: SecE; COG0690
373153005715	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
373153005716	Transglycosylase; Region: Transgly; pfam00912
373153005717	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
373153005718	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
373153005719	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
373153005720	active site
373153005721	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
373153005722	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
373153005723	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
373153005724	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
373153005725	FtsX-like permease family; Region: FtsX; pfam02687
373153005726	nicotinate-nucleotide pyrophosphorylase; Provisional; Region: PRK06559
373153005727	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
373153005728	dimerization interface [polypeptide binding]; other site
373153005729	active site
373153005730	Dicarboxylate carrier protein MatC N-terminus; Region: MatC_N; pfam07158
373153005731	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
373153005732	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
373153005733	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
373153005734	Walker A/P-loop; other site
373153005735	ATP binding site [chemical binding]; other site
373153005736	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
373153005737	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
373153005738	DNA-binding site [nucleotide binding]; DNA binding site
373153005739	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
373153005740	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
373153005741	beta-galactosidase; Region: BGL; TIGR03356
373153005742	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
373153005743	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
373153005744	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
373153005745	active site
373153005746	P-loop; other site
373153005747	phosphorylation site [posttranslational modification]
373153005748	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
373153005749	methionine cluster; other site
373153005750	active site
373153005751	phosphorylation site [posttranslational modification]
373153005752	metal binding site [ion binding]; metal-binding site
373153005753	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
373153005754	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
373153005755	putative catalytic cysteine [active]
373153005756	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
373153005757	putative active site [active]
373153005758	metal binding site [ion binding]; metal-binding site
373153005759	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
373153005760	MORN repeat; Region: MORN; cl14787
373153005761	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
373153005762	Low molecular weight phosphatase family; Region: LMWPc; cd00115
373153005763	active site
373153005764	preprotein translocase subunit YajC; Validated; Region: yajC; PRK06531
373153005765	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
373153005766	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
373153005767	TPP-binding site [chemical binding]; other site
373153005768	dimer interface [polypeptide binding]; other site
373153005769	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
373153005770	PYR/PP interface [polypeptide binding]; other site
373153005771	dimer interface [polypeptide binding]; other site
373153005772	TPP binding site [chemical binding]; other site
373153005773	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
373153005774	putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709
373153005775	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
373153005776	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
373153005777	PRD domain; Region: PRD; pfam00874
373153005778	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
373153005779	active site
373153005780	P-loop; other site
373153005781	phosphorylation site [posttranslational modification]
373153005782	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
373153005783	L-ribulose-5-phosphate 4-epimerase; Provisional; Region: araD; PRK13145
373153005784	intersubunit interface [polypeptide binding]; other site
373153005785	active site
373153005786	Zn2+ binding site [ion binding]; other site
373153005787	putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210
373153005788	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
373153005789	AP (apurinic/apyrimidinic) site pocket; other site
373153005790	DNA interaction; other site
373153005791	Metal-binding active site; metal-binding site
373153005792	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
373153005793	active site
373153005794	dimer interface [polypeptide binding]; other site
373153005795	magnesium binding site [ion binding]; other site
373153005796	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
373153005797	active site
373153005798	phosphorylation site [posttranslational modification]
373153005799	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
373153005800	active site
373153005801	P-loop; other site
373153005802	phosphorylation site [posttranslational modification]
373153005803	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: PRK12997
373153005804	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
373153005805	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
373153005806	G-X-X-G motif; other site
373153005807	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
373153005808	RxxxH motif; other site
373153005809	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
373153005810	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
373153005811	ribonuclease P; Reviewed; Region: rnpA; PRK00499
373153005812	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
373153005813	propionate/acetate kinase; Provisional; Region: PRK12379
373153005814	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
373153005815	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
373153005816	S-adenosylmethionine binding site [chemical binding]; other site
373153005817	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
373153005818	Competence protein ComGF [Intracellular trafficking and secretion]; Region: ComGF; COG4940
373153005819	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
373153005820	Type II secretory pathway pseudopilin; Region: PulG; pfam11773
373153005821	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
373153005822	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
373153005823	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
373153005824	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
373153005825	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
373153005826	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
373153005827	Walker A motif; other site
373153005828	ATP binding site [chemical binding]; other site
373153005829	Walker B motif; other site
373153005830	Protein of unknown function (DUF1033); Region: DUF1033; pfam06279
373153005831	formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH2; cd08286
373153005832	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
373153005833	catalytic Zn binding site [ion binding]; other site
373153005834	structural Zn binding site [ion binding]; other site
373153005835	NAD(P) binding site [chemical binding]; other site
373153005836	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
373153005837	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
373153005838	active site
373153005839	dimer interface [polypeptide binding]; other site
373153005840	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
373153005841	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
373153005842	catalytic triad [active]
373153005843	catalytic triad [active]
373153005844	oxyanion hole [active]
373153005845	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
373153005846	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
373153005847	Predicted integral membrane protein [Function unknown]; Region: COG5523
373153005848	Predicted membrane protein [Function unknown]; Region: COG3759
373153005849	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
373153005850	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
373153005851	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
373153005852	motif II; other site
373153005853	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
373153005854	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
373153005855	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
373153005856	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
373153005857	pyridoxal 5'-phosphate binding site [chemical binding]; other site
373153005858	catalytic residue [active]
373153005859	Gamma-glutamylcysteine synthetase [Coenzyme metabolism]; Region: GshA; COG3572
373153005860	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
373153005861	active site
373153005862	catalytic motif [active]
373153005863	Zn binding site [ion binding]; other site
373153005864	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
373153005865	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
373153005866	active site
373153005867	HIGH motif; other site
373153005868	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
373153005869	active site
373153005870	KMSKS motif; other site
373153005871	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
373153005872	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
373153005873	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
373153005874	active site
373153005875	dimer interface [polypeptide binding]; other site
373153005876	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
373153005877	dimer interface [polypeptide binding]; other site
373153005878	active site
373153005879	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
373153005880	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
373153005881	catalytic triad [active]
373153005882	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
373153005883	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
373153005884	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
373153005885	Walker A/P-loop; other site
373153005886	ATP binding site [chemical binding]; other site
373153005887	Q-loop/lid; other site
373153005888	ABC transporter signature motif; other site
373153005889	Walker B; other site
373153005890	D-loop; other site
373153005891	H-loop/switch region; other site
373153005892	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
373153005893	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
373153005894	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
373153005895	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
373153005896	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
373153005897	Walker A/P-loop; other site
373153005898	ATP binding site [chemical binding]; other site
373153005899	Q-loop/lid; other site
373153005900	ABC transporter signature motif; other site
373153005901	Walker B; other site
373153005902	D-loop; other site
373153005903	H-loop/switch region; other site
373153005904	DNA mismatch repair protein MutS; Region: mutS1; TIGR01070
373153005905	MutS domain I; Region: MutS_I; pfam01624
373153005906	MutS domain II; Region: MutS_II; pfam05188
373153005907	MutS domain III; Region: MutS_III; pfam05192
373153005908	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
373153005909	Walker A/P-loop; other site
373153005910	ATP binding site [chemical binding]; other site
373153005911	Q-loop/lid; other site
373153005912	ABC transporter signature motif; other site
373153005913	Walker B; other site
373153005914	D-loop; other site
373153005915	H-loop/switch region; other site
373153005916	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
373153005917	arginine repressor; Region: argR_whole; TIGR01529
373153005918	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
373153005919	arginyl-tRNA synthetase; Reviewed; Region: PRK12451
373153005920	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
373153005921	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
373153005922	active site
373153005923	HIGH motif; other site
373153005924	KMSK motif region; other site
373153005925	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
373153005926	tRNA binding surface [nucleotide binding]; other site
373153005927	anticodon binding site; other site
373153005928	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
373153005929	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
373153005930	Uncharacterized conserved protein [Function unknown]; Region: COG3542
373153005931	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
373153005932	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
373153005933	active site
373153005934	phosphorylation site [posttranslational modification]
373153005935	intermolecular recognition site; other site
373153005936	dimerization interface [polypeptide binding]; other site
373153005937	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
373153005938	DNA binding site [nucleotide binding]
373153005939	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
373153005940	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
373153005941	dimer interface [polypeptide binding]; other site
373153005942	phosphorylation site [posttranslational modification]
373153005943	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
373153005944	ATP binding site [chemical binding]; other site
373153005945	G-X-G motif; other site
373153005946	PBP superfamily domain; Region: PBP_like_2; cl17296
373153005947	ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226
373153005948	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
373153005949	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
373153005950	dimer interface [polypeptide binding]; other site
373153005951	conserved gate region; other site
373153005952	putative PBP binding loops; other site
373153005953	ABC-ATPase subunit interface; other site
373153005954	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
373153005955	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
373153005956	dimer interface [polypeptide binding]; other site
373153005957	conserved gate region; other site
373153005958	putative PBP binding loops; other site
373153005959	ABC-ATPase subunit interface; other site
373153005960	phosphate transporter ATP-binding protein; Provisional; Region: PRK14240
373153005961	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
373153005962	Walker A/P-loop; other site
373153005963	ATP binding site [chemical binding]; other site
373153005964	Q-loop/lid; other site
373153005965	ABC transporter signature motif; other site
373153005966	Walker B; other site
373153005967	D-loop; other site
373153005968	H-loop/switch region; other site
373153005969	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
373153005970	PhoU domain; Region: PhoU; pfam01895
373153005971	PhoU domain; Region: PhoU; pfam01895
373153005972	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
373153005973	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
373153005974	non-specific DNA binding site [nucleotide binding]; other site
373153005975	salt bridge; other site
373153005976	sequence-specific DNA binding site [nucleotide binding]; other site
373153005977	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
373153005978	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
373153005979	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
373153005980	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
373153005981	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
373153005982	active site
373153005983	tetramer interface; other site
373153005984	Rhomboid family; Region: Rhomboid; pfam01694
373153005985	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
373153005986	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
373153005987	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
373153005988	M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670
373153005989	metal binding site [ion binding]; metal-binding site
373153005990	putative dimer interface [polypeptide binding]; other site
373153005991	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
373153005992	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
373153005993	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
373153005994	trimer interface [polypeptide binding]; other site
373153005995	active site
373153005996	substrate binding site [chemical binding]; other site
373153005997	CoA binding site [chemical binding]; other site
373153005998	EamA-like transporter family; Region: EamA; pfam00892
373153005999	Transglycosylase; Region: Transgly; pfam00912
373153006000	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
373153006001	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
373153006002	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
373153006003	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
373153006004	active site
373153006005	HIGH motif; other site
373153006006	dimer interface [polypeptide binding]; other site
373153006007	KMSKS motif; other site
373153006008	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
373153006009	RNA binding surface [nucleotide binding]; other site
373153006010	heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525
373153006011	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
373153006012	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
373153006013	motif II; other site
373153006014	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
373153006015	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
373153006016	S-adenosylmethionine binding site [chemical binding]; other site
373153006017	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
373153006018	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
373153006019	4-alpha-glucanotransferase; Provisional; Region: PRK14508
373153006020	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
373153006021	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
373153006022	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
373153006023	dimer interface [polypeptide binding]; other site
373153006024	conserved gate region; other site
373153006025	putative PBP binding loops; other site
373153006026	ABC-ATPase subunit interface; other site
373153006027	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
373153006028	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
373153006029	dimer interface [polypeptide binding]; other site
373153006030	conserved gate region; other site
373153006031	putative PBP binding loops; other site
373153006032	ABC-ATPase subunit interface; other site
373153006033	Predicted integral membrane protein [Function unknown]; Region: COG5521
373153006034	Transcriptional regulators [Transcription]; Region: PurR; COG1609
373153006035	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
373153006036	DNA binding site [nucleotide binding]
373153006037	domain linker motif; other site
373153006038	Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294
373153006039	putative dimerization interface [polypeptide binding]; other site
373153006040	putative ligand binding site [chemical binding]; other site
373153006041	Uncharacterized conserved protein [Function unknown]; Region: COG1284
373153006042	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
373153006043	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
373153006044	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
373153006045	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
373153006046	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
373153006047	dimer interface [polypeptide binding]; other site
373153006048	anticodon binding site; other site
373153006049	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
373153006050	homodimer interface [polypeptide binding]; other site
373153006051	motif 1; other site
373153006052	active site
373153006053	motif 2; other site
373153006054	GAD domain; Region: GAD; pfam02938
373153006055	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
373153006056	motif 3; other site
373153006057	CAAX protease self-immunity; Region: Abi; pfam02517
373153006058	Protein of unknown function (DUF3169); Region: DUF3169; pfam11368
373153006059	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
373153006060	non-specific DNA binding site [nucleotide binding]; other site
373153006061	salt bridge; other site
373153006062	sequence-specific DNA binding site [nucleotide binding]; other site
373153006063	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
373153006064	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
373153006065	dimer interface [polypeptide binding]; other site
373153006066	motif 1; other site
373153006067	active site
373153006068	motif 2; other site
373153006069	motif 3; other site
373153006070	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
373153006071	anticodon binding site; other site
373153006072	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
373153006073	non-specific DNA binding site [nucleotide binding]; other site
373153006074	salt bridge; other site
373153006075	sequence-specific DNA binding site [nucleotide binding]; other site
373153006076	transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716
373153006077	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
373153006078	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
373153006079	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
373153006080	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
373153006081	PYR/PP interface [polypeptide binding]; other site
373153006082	dimer interface [polypeptide binding]; other site
373153006083	TPP binding site [chemical binding]; other site
373153006084	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
373153006085	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
373153006086	TPP-binding site [chemical binding]; other site
373153006087	dimer interface [polypeptide binding]; other site
373153006088	PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410
373153006089	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
373153006090	active site
373153006091	P-loop; other site
373153006092	phosphorylation site [posttranslational modification]
373153006093	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
373153006094	PRD domain; Region: PRD; pfam00874
373153006095	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
373153006096	active site
373153006097	P-loop; other site
373153006098	phosphorylation site [posttranslational modification]
373153006099	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
373153006100	active site
373153006101	phosphorylation site [posttranslational modification]
373153006102	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
373153006103	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_2; cd03402
373153006104	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
373153006105	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
373153006106	Leucine rich repeats (6 copies); Region: LRR_5; pfam13306
373153006107	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
373153006108	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
373153006109	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
373153006110	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
373153006111	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
373153006112	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
373153006113	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
373153006114	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
373153006115	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
373153006116	Divergent AAA domain; Region: AAA_4; pfam04326
373153006117	DDE superfamily endonuclease; Region: DDE_4_2; pfam13613
373153006118	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3293
373153006119	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
373153006120	Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA  is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565
373153006121	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
373153006122	putative active site [active]
373153006123	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
373153006124	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
373153006125	nucleotide binding site [chemical binding]; other site
373153006126	Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383
373153006127	N-terminal catalytic domain of SPGH38, a putative alpha-mannosidase of Streptococcus pyogenes, and its prokaryotic homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_SpGH38_like; cd10814
373153006128	active site
373153006129	metal binding site [ion binding]; metal-binding site
373153006130	homodimer interface [polypeptide binding]; other site
373153006131	catalytic site [active]
373153006132	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
373153006133	Uncharacterized conserved protein [Function unknown]; Region: COG3538
373153006134	Protein of unknown function (DUF1237); Region: DUF1237; pfam06824
373153006135	Putative alpha-1,2-mannosidase [Carbohydrate transport and metabolism]; Region: COG3537
373153006136	Glycosyl hydrolase family 92; Region: Glyco_hydro_92; pfam07971
373153006137	Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669
373153006138	Alpha-L-fucosidase; Region: Alpha_L_fucos; cl12119
373153006139	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
373153006140	ornithine carbamoyltransferase; Validated; Region: PRK02102
373153006141	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
373153006142	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
373153006143	carbamate kinase; Reviewed; Region: PRK12686
373153006144	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
373153006145	putative substrate binding site [chemical binding]; other site
373153006146	nucleotide binding site [chemical binding]; other site
373153006147	nucleotide binding site [chemical binding]; other site
373153006148	homodimer interface [polypeptide binding]; other site
373153006149	Predicted membrane protein [Function unknown]; Region: COG1288
373153006150	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
373153006151	hypothetical protein; Provisional; Region: PRK07205
373153006152	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
373153006153	active site
373153006154	metal binding site [ion binding]; metal-binding site
373153006155	M26 IgA1-specific Metallo-endopeptidase C-terminal region; Region: Peptidase_M26_C; pfam07580
373153006156	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
373153006157	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_4; cd03407
373153006158	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
373153006159	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
373153006160	dimer interface [polypeptide binding]; other site
373153006161	active site
373153006162	metal binding site [ion binding]; metal-binding site
373153006163	L-fucose isomerase; Provisional; Region: fucI; PRK10991
373153006164	L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556
373153006165	hexamer (dimer of trimers) interface [polypeptide binding]; other site
373153006166	trimer interface [polypeptide binding]; other site
373153006167	substrate binding site [chemical binding]; other site
373153006168	Mn binding site [ion binding]; other site
373153006169	Glycosyl hydrolase family 98; Region: Glyco_hydro_98M; pfam08306
373153006170	Glycosyl hydrolase family 98 C-terminal domain; Region: Glyco_hydro_98C; pfam08307
373153006171	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
373153006172	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
373153006173	Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042
373153006174	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
373153006175	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
373153006176	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
373153006177	active site
373153006178	phosphorylation site [posttranslational modification]
373153006179	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
373153006180	active pocket/dimerization site; other site
373153006181	active site
373153006182	phosphorylation site [posttranslational modification]
373153006183	Fucose dissimilation pathway protein FucU [Carbohydrate transport and metabolism]; Region: FucU; COG4154
373153006184	L-fuculose phosphate aldolase; Provisional; Region: PRK06833
373153006185	intersubunit interface [polypeptide binding]; other site
373153006186	active site
373153006187	Zn2+ binding site [ion binding]; other site
373153006188	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
373153006189	N- and C-terminal domain interface [polypeptide binding]; other site
373153006190	rhamnulokinase; Region: rhamnulo_kin; TIGR02627
373153006191	active site
373153006192	putative catalytic site [active]
373153006193	metal binding site [ion binding]; metal-binding site
373153006194	ATP binding site [chemical binding]; other site
373153006195	carbohydrate binding site [chemical binding]; other site
373153006196	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
373153006197	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
373153006198	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
373153006199	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
373153006200	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
373153006201	metal binding site [ion binding]; metal-binding site
373153006202	YodA lipocalin-like domain; Region: YodA; pfam09223
373153006203	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
373153006204	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
373153006205	ABC-ATPase subunit  interface; other site
373153006206	dimer interface [polypeptide binding]; other site
373153006207	putative PBP binding regions; other site
373153006208	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
373153006209	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
373153006210	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
373153006211	putative DNA binding site [nucleotide binding]; other site
373153006212	Protein involved in D-alanine esterification of lipoteichoic acid and wall teichoic acid (D-alanine transfer protein) [Cell envelope biogenesis, outer membrane]; Region: DltD; COG3966
373153006213	DltD N-terminal region; Region: DltD_N; pfam04915
373153006214	DltD central region; Region: DltD_M; pfam04918
373153006215	DltD C-terminal region; Region: DltD_C; pfam04914
373153006216	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087
373153006217	D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091
373153006218	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
373153006219	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
373153006220	acyl-activating enzyme (AAE) consensus motif; other site
373153006221	AMP binding site [chemical binding]; other site
373153006222	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
373153006223	H+ Antiporter protein; Region: 2A0121; TIGR00900
373153006224	putative substrate translocation pore; other site
373153006225	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
373153006226	amphipathic channel; other site
373153006227	Asn-Pro-Ala signature motifs; other site
373153006228	Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578
373153006229	glycerol kinase; Provisional; Region: glpK; PRK00047
373153006230	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
373153006231	N- and C-terminal domain interface [polypeptide binding]; other site
373153006232	active site
373153006233	MgATP binding site [chemical binding]; other site
373153006234	catalytic site [active]
373153006235	metal binding site [ion binding]; metal-binding site
373153006236	glycerol binding site [chemical binding]; other site
373153006237	homotetramer interface [polypeptide binding]; other site
373153006238	homodimer interface [polypeptide binding]; other site
373153006239	FBP binding site [chemical binding]; other site
373153006240	protein IIAGlc interface [polypeptide binding]; other site
373153006241	Mga helix-turn-helix domain; Region: Mga; pfam05043
373153006242	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
373153006243	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
373153006244	dimerization interface [polypeptide binding]; other site
373153006245	domain crossover interface; other site
373153006246	redox-dependent activation switch; other site
373153006247	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
373153006248	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
373153006249	FMN binding site [chemical binding]; other site
373153006250	active site
373153006251	catalytic residues [active]
373153006252	substrate binding site [chemical binding]; other site
373153006253	Gram-positive signal peptide, YSIRK family; Region: YSIRK_signal; TIGR01168
373153006254	RICH domain; Region: RICH; pfam05062
373153006255	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
373153006256	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
373153006257	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
373153006258	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
373153006259	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
373153006260	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
373153006261	glucan-binding repeat; Region: glucan_65_rpt; TIGR04035
373153006262	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
373153006263	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
373153006264	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1755
373153006265	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
373153006266	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
373153006267	dimerization interface [polypeptide binding]; other site
373153006268	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
373153006269	dimer interface [polypeptide binding]; other site
373153006270	phosphorylation site [posttranslational modification]
373153006271	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
373153006272	ATP binding site [chemical binding]; other site
373153006273	Mg2+ binding site [ion binding]; other site
373153006274	G-X-G motif; other site
373153006275	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
373153006276	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
373153006277	active site
373153006278	phosphorylation site [posttranslational modification]
373153006279	intermolecular recognition site; other site
373153006280	dimerization interface [polypeptide binding]; other site
373153006281	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
373153006282	DNA binding site [nucleotide binding]
373153006283	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
373153006284	Clp amino terminal domain; Region: Clp_N; pfam02861
373153006285	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
373153006286	Walker A motif; other site
373153006287	ATP binding site [chemical binding]; other site
373153006288	Walker B motif; other site
373153006289	arginine finger; other site
373153006290	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
373153006291	Walker A motif; other site
373153006292	ATP binding site [chemical binding]; other site
373153006293	Walker B motif; other site
373153006294	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
373153006295	Transcriptional repressor of class III stress genes [Transcription]; Region: CtsR; COG4463
373153006296	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
373153006297	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
373153006298	Walker A/P-loop; other site
373153006299	ATP binding site [chemical binding]; other site
373153006300	Q-loop/lid; other site
373153006301	ABC transporter signature motif; other site
373153006302	Walker B; other site
373153006303	D-loop; other site
373153006304	H-loop/switch region; other site
373153006305	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
373153006306	NMT1/THI5 like; Region: NMT1; pfam09084
373153006307	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
373153006308	Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528
373153006309	putative PBP binding loops; other site
373153006310	ABC-ATPase subunit interface; other site
373153006311	Uncharacterized conserved protein [Function unknown]; Region: COG0011
373153006312	Surface antigen [General function prediction only]; Region: COG3942
373153006313	CHAP domain; Region: CHAP; pfam05257
373153006314	Bacterial SH3 domain; Region: SH3_5; pfam08460
373153006315	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
373153006316	Bacterial SH3 domain; Region: SH3_5; pfam08460
373153006317	Putative cell wall binding repeat; Region: CW_binding_1; pfam01473
373153006318	Uncharacterized protein conserved in bacteria [Function unknown]; Region: Veg; COG4466
373153006319	replicative DNA helicase; Provisional; Region: PRK05748
373153006320	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
373153006321	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
373153006322	Walker A motif; other site
373153006323	ATP binding site [chemical binding]; other site
373153006324	Walker B motif; other site
373153006325	DNA binding loops [nucleotide binding]
373153006326	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
373153006327	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
373153006328	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
373153006329	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
373153006330	DHH family; Region: DHH; pfam01368
373153006331	DHHA1 domain; Region: DHHA1; pfam02272
373153006332	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
373153006333	30S subunit binding site; other site
373153006334	comF family protein; Region: comF; TIGR00201
373153006335	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
373153006336	active site
373153006337	Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098
373153006338	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
373153006339	ATP binding site [chemical binding]; other site
373153006340	putative Mg++ binding site [ion binding]; other site
373153006341	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
373153006342	nucleotide binding region [chemical binding]; other site
373153006343	ATP-binding site [chemical binding]; other site
373153006344	Uncharacterized conserved protein [Function unknown]; Region: COG1739
373153006345	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
373153006346	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
373153006347	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
373153006348	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
373153006349	dimer interface [polypeptide binding]; other site
373153006350	pyridoxal 5'-phosphate binding site [chemical binding]; other site
373153006351	catalytic residue [active]
373153006352	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
373153006353	elongation factor Ts; Provisional; Region: tsf; PRK09377
373153006354	UBA/TS-N domain; Region: UBA; pfam00627
373153006355	Elongation factor TS; Region: EF_TS; pfam00889
373153006356	Elongation factor TS; Region: EF_TS; pfam00889
373153006357	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
373153006358	rRNA interaction site [nucleotide binding]; other site
373153006359	S8 interaction site; other site
373153006360	putative laminin-1 binding site; other site
373153006361	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
373153006362	Septum formation initiator; Region: DivIC; cl17659
373153006363	Surface antigen [General function prediction only]; Region: COG3942
373153006364	CHAP domain; Region: CHAP; pfam05257
373153006365	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreD; COG2891
373153006366	Cell shape-determining protein [Cell envelope biogenesis, outer membrane]; Region: MreC; COG1792
373153006367	rod shape-determining protein MreC; Region: MreC; pfam04085
373153006368	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
373153006369	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13649
373153006370	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
373153006371	Walker A/P-loop; other site
373153006372	ATP binding site [chemical binding]; other site
373153006373	Q-loop/lid; other site
373153006374	ABC transporter signature motif; other site
373153006375	Walker B; other site
373153006376	D-loop; other site
373153006377	H-loop/switch region; other site
373153006378	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13650
373153006379	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
373153006380	Walker A/P-loop; other site
373153006381	ATP binding site [chemical binding]; other site
373153006382	Q-loop/lid; other site
373153006383	ABC transporter signature motif; other site
373153006384	Walker B; other site
373153006385	D-loop; other site
373153006386	H-loop/switch region; other site
373153006387	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
373153006388	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
373153006389	Helix-turn-helix domain; Region: HTH_25; pfam13413
373153006390	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
373153006391	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
373153006392	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
373153006393	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
373153006394	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
373153006395	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
373153006396	S4-like RNA binding protein [Replication, recombination, and repair]; Region: COG2501
373153006397	Recombinational DNA repair ATPase (RecF pathway) [DNA replication, recombination, and repair]; Region: RecF; COG1195
373153006398	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
373153006399	Walker A/P-loop; other site
373153006400	ATP binding site [chemical binding]; other site
373153006401	Q-loop/lid; other site
373153006402	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
373153006403	ABC transporter signature motif; other site
373153006404	Walker B; other site
373153006405	D-loop; other site
373153006406	H-loop/switch region; other site
373153006407	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
373153006408	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
373153006409	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
373153006410	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
373153006411	active site
373153006412	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
373153006413	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
373153006414	active site
373153006415	HIGH motif; other site
373153006416	dimer interface [polypeptide binding]; other site
373153006417	KMSKS motif; other site
373153006418	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
373153006419	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
373153006420	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
373153006421	ABC transporter; Region: ABC_tran_2; pfam12848
373153006422	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
373153006423	Predicted membrane protein [Function unknown]; Region: COG4485
373153006424	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
373153006425	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
373153006426	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
373153006427	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
373153006428	active site
373153006429	phosphorylation site [posttranslational modification]
373153006430	intermolecular recognition site; other site
373153006431	dimerization interface [polypeptide binding]; other site
373153006432	LytTr DNA-binding domain; Region: LytTR; pfam04397
373153006433	Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972
373153006434	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
373153006435	COMC family; Region: ComC; pfam03047
373153006436	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
373153006437	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
373153006438	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
373153006439	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
373153006440	protein binding site [polypeptide binding]; other site
373153006441	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
373153006442	ParB-like nuclease domain; Region: ParBc; pfam02195
373153006443	KorB domain; Region: KorB; pfam08535